Science.gov

Sample records for advanced measurement approaches

  1. Measuring Alumna Career Advancement: An Approach Based on Educational Expectations.

    ERIC Educational Resources Information Center

    Ben-Ur, Tamar; Rogers, Glen

    Alverno College (Wisconsin), a women's liberal arts college, has developed an Alumni Career Level Classification (AACLC) scheme to measure alumna career advancement and demonstrate institutional accountability. This validation study was part of a larger longitudinal study of two entire cohorts of students entering the college in 1976 and 1977, of…

  2. 12 CFR Appendix C to Part 567 - Risk-Based Capital Requirements-Internal-Ratings-Based and Advanced Measurement Approaches

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Risk-Based Capital Requirements-Internal-Ratings-Based and Advanced Measurement Approaches C Appendix C to Part 567 Banks and Banking OFFICE OF... Exposure Report); (iii) Is a subsidiary of a depository institution that uses 12 CFR part 3, appendix C,...

  3. Advanced Ceramics Property Measurements

    NASA Technical Reports Server (NTRS)

    Salem, Jonathan; Helfinstine, John; Quinn, George; Gonczy, Stephen

    2013-01-01

    Mechanical and physical properties of ceramic bodies can be difficult to measure correctly unless the proper techniques are used. The Advanced Ceramics Committee of ASTM, C-28, has developed dozens of consensus test standards and practices to measure various properties of a ceramic monolith, composite, or coating. The standards give the "what, how, how not, and why" for measurement of many mechanical, physical, thermal, and performance properties. Using these standards will provide accurate, reliable, and complete data for rigorous comparisons with other test results from your test lab, or another. The C-28 Committee has involved academics, producers, and users of ceramics to write and continually update more than 45 standards since the committee's inception in 1986. Included in this poster is a pictogram of the C-28 standards and information on how to obtain individual copies with full details or the complete collection of standards in one volume.

  4. 12 CFR Appendix D to Part 325 - Capital Adequacy Guidelines for Banks: Internal-Ratings-Based and Advanced Measurement Approaches

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Section 52Simple Risk Weight Approach (SRWA) Section 53Internal Models Approach (IMA) Section 54Equity... Exposure Report); (iii) Is a subsidiary of a depository institution that uses 12 CFR part 3, appendix C, 12 CFR part 208, appendix F, 12 CFR part 325, appendix D, or 12 CFR part 567, appendix C, to...

  5. 12 CFR Appendix C to Part 3 - Capital Adequacy Guidelines for Banks: Internal-Ratings-Based and Advanced Measurement Approaches

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Section 52Simple Risk Weight Approach (SRWA) Section 53Internal Models Approach (IMA) Section 54Equity... Exposure Report); (iii) Is a subsidiary of a depository institution that uses 12 CFR part 3, appendix C, 12 CFR part 208, appendix F, 12 CFR part 325, appendix D, or 12 CFR part 567, appendix C, to...

  6. Advanced Safeguards Approaches for New Reprocessing Facilities

    SciTech Connect

    Durst, Philip C.; Therios, Ike; Bean, Robert; Dougan, A.; Boyer, Brian; Wallace, Richard; Ehinger, Michael H.; Kovacic, Don N.; Tolk, K.

    2007-06-24

    U.S. efforts to promote the international expansion of nuclear energy through the Global Nuclear Energy Partnership (GNEP) will result in a dramatic expansion of nuclear fuel cycle facilities in the United States. New demonstration facilities, such as the Advanced Fuel Cycle Facility (AFCF), the Advanced Burner Reactor (ABR), and the Consolidated Fuel Treatment Center (CFTC) will use advanced nuclear and chemical process technologies that must incorporate increased proliferation resistance to enhance nuclear safeguards. The ASA-100 Project, “Advanced Safeguards Approaches for New Nuclear Fuel Cycle Facilities,” commissioned by the NA-243 Office of NNSA, has been tasked with reviewing and developing advanced safeguards approaches for these demonstration facilities. Because one goal of GNEP is developing and sharing proliferation-resistant nuclear technology and services with partner nations, the safeguards approaches considered are consistent with international safeguards as currently implemented by the International Atomic Energy Agency (IAEA). This first report reviews possible safeguards approaches for the new fuel reprocessing processes to be deployed at the AFCF and CFTC facilities. Similar analyses addressing the ABR and transuranic (TRU) fuel fabrication lines at AFCF and CFTC will be presented in subsequent reports.

  7. Reliability and Validity of Advanced Phonics Measures

    ERIC Educational Resources Information Center

    Doty, Sara J.; Hixson, Michael D.; Decker, Dawn M.; Reynolds, Jennifer L.; Drevon, Daniel D.

    2015-01-01

    Two studies explored the technical adequacy of various measures of advanced phonics skills. In Study 1, the advanced phonics measures consisted of pseudowords, real words, or a combination of both. Participants included 39 students in the third grade. Test-retest correlations for all measures were above 0.8 and interrater reliability was high.…

  8. Advanced approaches to focal plane integration

    NASA Astrophysics Data System (ADS)

    Nelson, R. D.; Smith, E. C., Jr.

    1980-01-01

    Both visible and infrared focal plane assemblies have common architectural driving parameters which guide their design approaches. The key drivers for advanced focal plane assemblies (FPA) are: the detector type and performance required; the number of detector chips; the packaging density; and the geometry. The impact of these drivers is seen to determine the engineering compromises necessary to establish FPA design approach. Several new designs are discussed which show a range of applications from single detector assemblies to monolithic detector chips with on-chip signal processing. The main objective of many advanced designs is to integrate the focal plane components in order to reduce power and reduce the number of interconnections.

  9. Advanced Placement European History: A New Approach.

    ERIC Educational Resources Information Center

    Beaber, Lawrence

    A new approach to the teaching of European history is being implemented in Advanced Placement secondary classes. In the latter 1950's a Committee of Examiners composed of European history professors and secondary teachers formulated a course description comprised of a brief outline of an introductory survey in European history. It was organized…

  10. Chemical Approaches for Advanced Optical Imaging

    NASA Astrophysics Data System (ADS)

    Chen, Zhixing

    Advances in optical microscopy have been constantly expanding our knowledge of biological systems. The achievements therein are a result of close collaborations between physicists/engineers who build the imaging instruments and chemists/biochemists who design the corresponding probe molecules. In this work I present a number of chemical approaches for the development of advanced optical imaging methods. Chapter 1 provides an overview of the recent advances of novel imaging approaches taking advantage of chemical tag technologies. Chapter 2 describes the second-generation covalent trimethoprim-tag as a viable tool for live cell protein-specific labeling and imaging. In Chapter 3 we present a fluorescence lifetime imaging approach to map protein-specific micro-environment in live cells using TMP-Cy3 as a chemical probe. In Chapter 4, we present a method harnessing photo-activatable fluorophores to extend the fundamental depth limit in multi-photon microscopy. Chapter 5 describes the development of isotopically edited alkyne palette for multi-color live cell vibrational imaging of cellular small molecules. These studies exemplify the impact of modern chemical approaches in the development of advanced optical microscopies.

  11. Advances in noninvasive bone measurement

    SciTech Connect

    Mazess, R.B.; Barden, H.; Vetter, J.; Ettinger, M.

    1989-01-01

    Several noninvasive measurement methods are used for evaluation of metabolic disease. Single-photon (/sup 125/I) scans of the peripheral skeleton are useful in some diseases but are ineffective in osteoporosis (even on the distal radius or os calcis) because they cannot predict spinal or femoral density. Also, peripheral measurements show high percentages of false negatives, that is many patients with fractures have normal peripheral density. Dual-photon (/sup 153/Gd) scans of the spine, femur, and total skeleton are precise and accurate (2% error) and provide direct measurements of bone strength at fracture sites. This gives the best discrimination of abnormality and the most sensitive monitoring. Quantitative computed computed tomography (QCT) allows measurement of the spine but not the critical proximal femur area. QCT has a large accuracy error because (a) the limited area measured (under 5 cm3) fails to represent the total vertebral body, (b) technical errors, and (c) variable fat and osteoid influence the results. 25 references.

  12. Advances in Ecological Speciation: an integrative approach.

    PubMed

    Faria, Rui; Renaut, Sebastien; Galindo, Juan; Pinho, Catarina; Melo-Ferreira, José; Melo, Martim; Jones, Felicity; Salzburger, Walter; Schluter, Dolph; Butlin, Roger

    2014-02-01

    The role of natural selection in promoting reproductive isolation has received substantial renewed interest within the last two decades. As a consequence, the study of ecological speciation has become an extremely productive research area in modern evolutionary biology. Recent innovations in sequencing technologies offer an unprecedented opportunity to study the mechanisms involved in ecological speciation. Genome scans provide significant insights but have some important limitations; efforts are needed to integrate them with other approaches to make full use of the sequencing data deluge. An international conference 'Advances in Ecological Speciation' organized by the University of Porto (Portugal) aimed to review current progress in ecological speciation. Using some of the examples presented at the conference, we highlight the benefits of integrating ecological and genomic data and discuss different mechanisms of parallel evolution. Finally, future avenues of research are suggested to advance our knowledge concerning the role of natural selection in the establishment of reproductive isolation during ecological speciation.

  13. The Advanced Noise Control Fan Baseline Measurements

    NASA Technical Reports Server (NTRS)

    McAllister, Joseph; Loew, Raymond A.; Lauer, Joel T.; Stuliff, Daniel L.

    2009-01-01

    The NASA Glenn Research Center s (NASA Glenn) Advanced Noise Control Fan (ANCF) was developed in the early 1990s to provide a convenient test bed to measure and understand fan-generated acoustics, duct propagation, and radiation to the farfield. As part of a complete upgrade, current baseline and acoustic measurements were documented. Extensive in-duct, farfield acoustic, and flow field measurements are reported. This is a follow-on paper to documenting the operating description of the ANCF.

  14. Advanced Approach of Multiagent Based Buoy Communication

    PubMed Central

    Gricius, Gediminas; Drungilas, Darius; Andziulis, Arunas; Dzemydiene, Dale; Voznak, Miroslav; Kurmis, Mindaugas; Jakovlev, Sergej

    2015-01-01

    Usually, a hydrometeorological information system is faced with great data flows, but the data levels are often excessive, depending on the observed region of the water. The paper presents advanced buoy communication technologies based on multiagent interaction and data exchange between several monitoring system nodes. The proposed management of buoy communication is based on a clustering algorithm, which enables the performance of the hydrometeorological information system to be enhanced. The experiment is based on the design and analysis of the inexpensive but reliable Baltic Sea autonomous monitoring network (buoys), which would be able to continuously monitor and collect temperature, waviness, and other required data. The proposed approach of multiagent based buoy communication enables all the data from the costal-based station to be monitored with limited transition speed by setting different tasks for the agent-based buoy system according to the clustering information. PMID:26345197

  15. Nonintrusive temperature measurements on advanced turbomachinery components

    SciTech Connect

    Noel, B.W.; Turley, W.D.; Lewis, W.

    1992-12-31

    A nonintrusive, noncontacting method we developed for temperature measurements in hostile environments is well-suited for measurements on advanced turbine components. The method is not only superior to thermocouples in sufficiently difficult environments, but also is the only known method for making measurements in situations where no form of pyrometry works. We demonstrated the method, which uses laser-induced fluorescence of thermographic phosphors bonded to the component surfaces, on turbine blades and vanes in developmental turbine engines. The method is extendable to the much-higher temperatures expected inside advanced turbomachinery. Of particular note is the adaptability of the method to surface-temperature measurements on ceramics operating at high temperatures. In this temperature range, the ceramics become translucent, and surface emissivity becomes meaningless. We shall discuss the method, its advantages and limitations, recent test results on operating turbine engines, and the extension to ceramic components.

  16. Advanced Measurement Systems Available to PIWG Members

    NASA Technical Reports Server (NTRS)

    Anderson, Robert; Lei, Jih-Fen (Technical Monitor)

    2002-01-01

    It was developed advanced measurement technologies to meet NASA goals: reduce design cycle time, reduce emission, reduce testing time, increase safety. The technology are saving money. This technology are available now for technology transfer: optical diagnostics, the film technology and MEMS devices.

  17. Recent advancement of turbulent flow measurement techniques

    NASA Technical Reports Server (NTRS)

    Battle, T.; Wang, P.; Cheng, D. Y.

    1974-01-01

    Advancements of the fluctuating density gradient cross beam laser Schlieren technique, the fluctuating line-reversal temperature measurement and the development of the two-dimensional drag-sensing probe to a three-dimensional drag-sensing probe are discussed. The three-dimensionality of the instantaneous momentum vector can shed some light on the nature of turbulence especially with swirling flow. All three measured fluctuating quantities (density, temperature, and momentum) can provide valuable information for theoreticians.

  18. Advanced optical blade tip clearance measurement system

    NASA Technical Reports Server (NTRS)

    Ford, M. J.; Honeycutt, R. E.; Nordlund, R. E.; Robinson, W. W.

    1978-01-01

    An advanced electro-optical system was developed to measure single blade tip clearances and average blade tip clearances between a rotor and its gas path seal in an operating gas turbine engine. This system is applicable to fan, compressor, and turbine blade tip clearance measurement requirements, and the system probe is particularly suitable for operation in the extreme turbine environment. A study of optical properties of blade tips was conducted to establish measurement system application limitations. A series of laboratory tests was conducted to determine the measurement system's operational performance characteristics and to demonstrate system capability under simulated operating gas turbine environmental conditions. Operational and environmental performance test data are presented.

  19. Advanced Safeguards Approaches for New Fast Reactors

    SciTech Connect

    Durst, Philip C.; Therios, Ike; Bean, Robert; Dougan, A.; Boyer, Brian; Wallace, Rick L.; Ehinger, Michael H.; Kovacic, Don N.; Tolk, K.

    2007-12-15

    This third report in the series reviews possible safeguards approaches for new fast reactors in general, and the ABR in particular. Fast-neutron spectrum reactors have been used since the early 1960s on an experimental and developmental level, generally with fertile blanket fuels to “breed” nuclear fuel such as plutonium. Whether the reactor is designed to breed plutonium, or transmute and “burn” actinides depends mainly on the design of the reactor neutron reflector and the whether the blanket fuel is “fertile” or suitable for transmutation. However, the safeguards issues are very similar, since they pertain mainly to the receipt, shipment and storage of fresh and spent plutonium and actinide-bearing “TRU”-fuel. For these reasons, the design of existing fast reactors and details concerning how they have been safeguarded were studied in developing advanced safeguards approaches for the new fast reactors. In this regard, the design of the Experimental Breeder Reactor-II “EBR-II” at the Idaho National Laboratory (INL) was of interest, because it was designed as a collocated fast reactor with a pyrometallurgical reprocessing and fuel fabrication line – a design option being considered for the ABR. Similarly, the design of the Fast Flux Facility (FFTF) on the Hanford Site was studied, because it was a successful prototype fast reactor that ran for two decades to evaluate fuels and the design for commercial-scale fast reactors.

  20. Uncertainty quantification approaches for advanced reactor analyses.

    SciTech Connect

    Briggs, L. L.; Nuclear Engineering Division

    2009-03-24

    The original approach to nuclear reactor design or safety analyses was to make very conservative modeling assumptions so as to ensure meeting the required safety margins. Traditional regulation, as established by the U. S. Nuclear Regulatory Commission required conservatisms which have subsequently been shown to be excessive. The commission has therefore moved away from excessively conservative evaluations and has determined best-estimate calculations to be an acceptable alternative to conservative models, provided the best-estimate results are accompanied by an uncertainty evaluation which can demonstrate that, when a set of analysis cases which statistically account for uncertainties of all types are generated, there is a 95% probability that at least 95% of the cases meet the safety margins. To date, nearly all published work addressing uncertainty evaluations of nuclear power plant calculations has focused on light water reactors and on large-break loss-of-coolant accident (LBLOCA) analyses. However, there is nothing in the uncertainty evaluation methodologies that is limited to a specific type of reactor or to specific types of plant scenarios. These same methodologies can be equally well applied to analyses for high-temperature gas-cooled reactors and to liquid metal reactors, and they can be applied to steady-state calculations, operational transients, or severe accident scenarios. This report reviews and compares both statistical and deterministic uncertainty evaluation approaches. Recommendations are given for selection of an uncertainty methodology and for considerations to be factored into the process of evaluating uncertainties for advanced reactor best-estimate analyses.

  1. Advances on interdisciplinary approaches to urban carbon

    NASA Astrophysics Data System (ADS)

    Romero-Lankao, P.

    2015-12-01

    North American urban areas are emerging as climate policy and technology innovators, urbanization process laboratories, fonts of carbon relevant experiments, hubs for grass-roots mobilization, and centers for civil-society experiments to curb carbon emissions and avoid widespread and irreversible climate impacts. Since SOCCR diverse lines of inquiry on urbanization, urban areas and the carbon cycle have advanced our understanding of some of the societal processes through which energy and land uses affect carbon. This presentation provides an overview of these diverse perspectives. It suggests the need for approaches that complement and combine the plethora of existing insights into interdisciplinary explorations of how different urbanization processes, and socio-ecological and technological components of urban areas affect the spatial and temporal patterns of carbon emissions, differentially over time and within and across cities. It also calls for a more holistic approach to examining the carbon implications of urbanization and urban areas as places, based not only on demographics or income, but also on such other interconnected features of urban development pathways as urban form, economic function, economic growth policies and climate policies.

  2. Fluid and structural measurements to advance gas turbine technology

    NASA Technical Reports Server (NTRS)

    Hartmann, M. J.

    1980-01-01

    In the present paper, the current status of fluid and structural measurements is reviewed, and some potential improvements in gas turbine machinery, directly associated with the new measuring capability are discussed. Some considerations concerning the impact of the new capability on the methods and approaches that will be used in the further development of advanced technology, in general, and to aeropropulsion gas turbine machinery, in particular, are presented.

  3. Advanced Engineering Technology for Measuring Performance.

    PubMed

    Rutherford, Drew N; D'Angelo, Anne-Lise D; Law, Katherine E; Pugh, Carla M

    2015-08-01

    The demand for competency-based assessments in surgical training is growing. Use of advanced engineering technology for clinical skills assessment allows for objective measures of hands-on performance. Clinical performance can be assessed in several ways via quantification of an assessee's hand movements (motion tracking), direction of visual attention (eye tracking), levels of stress (physiologic marker measurements), and location and pressure of palpation (force measurements). Innovations in video recording technology and qualitative analysis tools allow for a combination of observer- and technology-based assessments. Overall the goal is to create better assessments of surgical performance with robust validity evidence.

  4. Measuring Combustion Advance in Solid Propellants

    NASA Technical Reports Server (NTRS)

    Yang, L. C.

    1986-01-01

    Set of gauges on solid-propellant rocket motor with electrically insulating case measures advance of combustion front and local erosion rates of propellant and insulation. Data furnished by gauges aid in motor design, failure analysis, and performance prediction. Technique useful in determining propellant uniformity and electrical properties of exhaust plum. Gauges used both in flight and on ground. Foilgauge technique also useful in basic research on pulsed plasmas or combustion of solids.

  5. Multilayer Approach for Advanced Hybrid Lithium Battery.

    PubMed

    Ming, Jun; Li, Mengliu; Kumar, Pushpendra; Li, Lain-Jong

    2016-06-28

    Conventional intercalated rechargeable batteries have shown their capacity limit, and the development of an alternative battery system with higher capacity is strongly needed for sustainable electrical vehicles and hand-held devices. Herein, we introduce a feasible and scalable multilayer approach to fabricate a promising hybrid lithium battery with superior capacity and multivoltage plateaus. A sulfur-rich electrode (90 wt % S) is covered by a dual layer of graphite/Li4Ti5O12, where the active materials S and Li4Ti5O12 can both take part in redox reactions and thus deliver a high capacity of 572 mAh gcathode(-1) (vs the total mass of electrode) or 1866 mAh gs(-1) (vs the mass of sulfur) at 0.1C (with the definition of 1C = 1675 mA gs(-1)). The battery shows unique voltage platforms at 2.35 and 2.1 V, contributed from S, and 1.55 V from Li4Ti5O12. A high rate capability of 566 mAh gcathode(-1) at 0.25C and 376 mAh gcathode(-1) at 1C with durable cycle ability over 100 cycles can be achieved. Operando Raman and electron microscope analysis confirm that the graphite/Li4Ti5O12 layer slows the dissolution/migration of polysulfides, thereby giving rise to a higher sulfur utilization and a slower capacity decay. This advanced hybrid battery with a multilayer concept for marrying different voltage plateaus from various electrode materials opens a way of providing tunable capacity and multiple voltage platforms for energy device applications. PMID:27268064

  6. Multilayer Approach for Advanced Hybrid Lithium Battery.

    PubMed

    Ming, Jun; Li, Mengliu; Kumar, Pushpendra; Li, Lain-Jong

    2016-06-28

    Conventional intercalated rechargeable batteries have shown their capacity limit, and the development of an alternative battery system with higher capacity is strongly needed for sustainable electrical vehicles and hand-held devices. Herein, we introduce a feasible and scalable multilayer approach to fabricate a promising hybrid lithium battery with superior capacity and multivoltage plateaus. A sulfur-rich electrode (90 wt % S) is covered by a dual layer of graphite/Li4Ti5O12, where the active materials S and Li4Ti5O12 can both take part in redox reactions and thus deliver a high capacity of 572 mAh gcathode(-1) (vs the total mass of electrode) or 1866 mAh gs(-1) (vs the mass of sulfur) at 0.1C (with the definition of 1C = 1675 mA gs(-1)). The battery shows unique voltage platforms at 2.35 and 2.1 V, contributed from S, and 1.55 V from Li4Ti5O12. A high rate capability of 566 mAh gcathode(-1) at 0.25C and 376 mAh gcathode(-1) at 1C with durable cycle ability over 100 cycles can be achieved. Operando Raman and electron microscope analysis confirm that the graphite/Li4Ti5O12 layer slows the dissolution/migration of polysulfides, thereby giving rise to a higher sulfur utilization and a slower capacity decay. This advanced hybrid battery with a multilayer concept for marrying different voltage plateaus from various electrode materials opens a way of providing tunable capacity and multiple voltage platforms for energy device applications.

  7. Advanced Microgravity Acceleration Measurement Systems Being Developed

    NASA Technical Reports Server (NTRS)

    Sicker, Ronald J.; Kacpura, Thomas J.

    2002-01-01

    The Advanced Microgravity Acceleration Measurement Systems (AMAMS) project at the NASA Glenn Research Center is part of the Instrument Technology Development program to develop advanced sensor systems. The primary focus of the AMAMS project is to develop microelectromechanical (MEMS) acceleration sensor systems to replace existing electromechanical-sensor-based systems presently used to assess relative gravity levels aboard spacecraft. These systems are used in characterizing both vehicle and payload responses to low-gravity vibroacoustic environments. The collection of microgravity acceleration data has cross-disciplinary utility to the microgravity life and physical sciences and the structural dynamics communities. The inherent advantages of semiconductor-based systems are reduced size, mass, and power consumption, while providing enhanced stability.

  8. Advanced Ceramics Property and Performance Measurements

    NASA Technical Reports Server (NTRS)

    Jenkins, Michael; Salem, Jonathan; Helfinstine, John; Quinn, George; Gonczy, Stephen

    2015-01-01

    Mechanical and physical properties of ceramic bodies can be difficult to measure correctly unless the proper techniques are used. The Advanced Ceramics Committee of ASTM, C-28, has developed dozens of consensus test standards and practices to measure various properties of a ceramic monolith, composite, or coating. The standards give the what, how, how not, and why for measurement of many mechanical, physical, thermal, and performance properties. Using these standards will provide accurate, reliable, and complete data for rigorous comparisons with other test results from your test lab, or another. The C-28 Committee has involved academics, producers, and users of ceramics to write and continually update more than 45 standards since the committees inception in 1986. Included in this poster is a pictogram of the C-28 standards and information on how to obtain individual copies with full details or the complete collection of all of the standards in one volume.

  9. ANDES Measurements for Advanced Reactor Systems

    NASA Astrophysics Data System (ADS)

    Plompen, A. J. M.; Hambsch, F.-J.; Kopecky, S.; Nyman, M.; Rouki, C.; Salvador Castiñeira, P.; Schillebeeckx, P.; Belloni, F.; Berthoumieux, E.; Gunsing, F.; Lampoudis, C.; Calviani, M.; Guerrero, C.; Cano-Ott, D.; Gonzalez Romero, E.; Aïche, M.; Jurado, B.; Mathieu, L.; Derckx, X.; Farget, F.; Rodrigues Tajes, C.; Bacquias, A.; Dessagne, Ph.; Kerveno, M.; Borcea, C.; Negret, A.; Colonna, N.; Goncalves, I.; Penttilä, H.; Rinta-Antila, S.; Kolhinen, V. S.; Jokinen, A.

    2014-05-01

    A significant number of new measurements was undertaken by the ANDES “Measurements for advanced reactor systems” initiative. These new measurements include neutron inelastic scattering from 23Na, Mo, Zr, and 238U, neutron capture cross sections of 238U, 241Am, neutron induced fission cross sections of 240Pu, 242Pu, 241Am, 243Am and 245Cm, and measurements that explore the limits of the surrogate technique. The latter study the feasibility of inferring neutron capture cross sections for Cm isotopes, the neutron-induced fission cross section of 238Pu and fission yields and fission probabilities through full Z and A identification in inverse kinematics for isotopes of Pu, Am, Cm and Cf. Finally, four isotopes are studied which are important to improve predictions for delayed neutron precursors and decay heat by total absorption gamma-ray spectrometry (88Br, 94Rb, 95Rb, 137I). The measurements which are performed at state-of-the-art European facilities have the ambition to achieve the lowest possible uncertainty, and to come as close as is reasonably achievable to the target uncertainties established by sensitivity studies. An overview is presented of the activities and achievements, leaving detailed expositions to the various parties contributing to the conference.

  10. Advanced interferometric profile measurements through refractive media

    SciTech Connect

    Koev, Stephan T.; Ghodssi, Reza

    2008-09-15

    Optical profilers are valuable tools for the characterization of microelectromechanical systems (MEMSs). They use phase sifting interferometry (PSI) or vertical scanning interferometry to measure the topography of microscale structures with nanometer resolution. However, for many emerging MEMS applications, the sample needs to be imaged while placed in a liquid or in a package with a glass window. The increased refractive index of the transparent medium degrades the interference image contrast and prevents any measurement of the sample. We report on the modification of a Veeco NT1100 optical profiler to enable PSI measurements through refractive media. This approach can be applied to any other optical profiler with PSI capability. The modification consists in replacing the original illumination source with a custom-built narrow linewidth source, which increases the coherence length of the light and the contrast of the interference image. We present measurements taken with the modified configuration on samples covered with 3 mm water or 500 {mu}m glass, and we compare them to measurements of uncovered samples. We show that the measurement precision is only slightly reduced by the water and glass, and that it is still sufficiently high for typical MEMS applications. The described method can be readily used for measuring through other types and thicknesses of refractive materials.

  11. Measuring Test Measurement Error: A General Approach

    ERIC Educational Resources Information Center

    Boyd, Donald; Lankford, Hamilton; Loeb, Susanna; Wyckoff, James

    2013-01-01

    Test-based accountability as well as value-added asessments and much experimental and quasi-experimental research in education rely on achievement tests to measure student skills and knowledge. Yet, we know little regarding fundamental properties of these tests, an important example being the extent of measurement error and its implications for…

  12. [Approach to dysphagia in advanced dementia].

    PubMed

    Gómez-Busto, Fernando; Andia, Virginia; Ruiz de Alegria, Loli; Francés, Inés

    2009-11-01

    From the onset, dementia affects the patient's nutritional status, producing anorexia, weight loss, feeding apraxia and dysphagia. Distinct strategies are required in each of the stages of this disease, starting with awareness and knowledge of the problem and its prompt detection. In dementia, dysphagia usually appears in advanced phases, when the patient is often institutionalized. When dysphagia is suspected, the patient's tolerance must be evaluated by the volume/viscosity test, environmental and postural strategies should be introduced, and the texture of the diet should be modified. This is a complex task requiring the involvement of a properly trained interdisciplinary team, able to provide information and alternatives and integrate the family environment in the patient's care. The adapted diet should be based on the traditional diet that can also be combined with artificial supplements to provide a varied diet that increases patients', caregivers' and relatives' satisfaction. Tube feeding has shown no nutritional benefits in patients with advanced dementia. Therefore, we propose assisted oral feeding as the most natural and appropriate form of feeding in these patients, always respecting their previously expressed wishes.

  13. Advancing Instructional Communication: Integrating a Biosocial Approach

    ERIC Educational Resources Information Center

    Horan, Sean M.; Afifi, Tamara D.

    2014-01-01

    Celebrating 100 years of the National Communication Association necessitates that, as we commemorate our past, we also look toward our future. As part of a larger conversation about the future of instructional communication, this essay reinvestigates the importance of integrating biosocial approaches into instructional communication research. In…

  14. Approaches for advancing scientific understanding of macrosystems

    USGS Publications Warehouse

    Levy, Ofir; Ball, Becky A.; Bond-Lamberty, Ben; Cheruvelil, Kendra S.; Finley, Andrew O.; Lottig, Noah R.; Surangi W. Punyasena,; Xiao, Jingfeng; Zhou, Jizhong; Buckley, Lauren B.; Filstrup, Christopher T.; Keitt, Tim H.; Kellner, James R.; Knapp, Alan K.; Richardson, Andrew D.; Tcheng, David; Toomey, Michael; Vargas, Rodrigo; Voordeckers, James W.; Wagner, Tyler; Williams, John W.

    2014-01-01

    The emergence of macrosystems ecology (MSE), which focuses on regional- to continental-scale ecological patterns and processes, builds upon a history of long-term and broad-scale studies in ecology. Scientists face the difficulty of integrating the many elements that make up macrosystems, which consist of hierarchical processes at interacting spatial and temporal scales. Researchers must also identify the most relevant scales and variables to be considered, the required data resources, and the appropriate study design to provide the proper inferences. The large volumes of multi-thematic data often associated with macrosystem studies typically require validation, standardization, and assimilation. Finally, analytical approaches need to describe how cross-scale and hierarchical dynamics and interactions relate to macroscale phenomena. Here, we elaborate on some key methodological challenges of MSE research and discuss existing and novel approaches to meet them.

  15. Advances in myelofibrosis: a clinical case approach

    PubMed Central

    Mascarenhas, John O.; Orazi, Attilio; Bhalla, Kapil N.; Champlin, Richard E.; Harrison, Claire; Hoffman, Ronald

    2013-01-01

    Primary myelofibrosis is a member of the myeloproliferative neoplasms, a diverse group of bone marrow malignancies. Symptoms of myelofibrosis, particularly those associated with splenomegaly (abdominal distention and pain, early satiety, dyspnea, and diarrhea) and constitutional symptoms, represent a substantial burden to patients. Most patients eventually die from the disease, with a median survival ranging from approximately 5–7 years. Mutations in Janus kinase 2 (JAK2), a kinase that is essential for the normal development of erythrocytes, granulocytes, and platelets, notably the V617F mutation, have been identified in approximately 50% of patients with myelofibrosis. The approval of a JAK2 inhibitor in 2011 has improved the outlook of many patients with myelofibrosis and has changed the treatment landscape. This article focuses on some of the important issues in current myelofibrosis treatment management, including differentiation of myelofibrosis from essential thrombocythemia and polycythemia vera, up-dated data on the results of JAK2 inhibitor therapy, the role of epigenetic mechanisms in myelofibrosis pathogenesis, investigational therapies for myelofibrosis, and advances in hematopoietic stem cell transplant. Three myelofibrosis cases are included to underscore the issues in diagnosing and treating this complex disease. PMID:24091929

  16. Advancing Profiling Sensors with a Wireless Approach

    PubMed Central

    Galvis, Alex; Russomanno, David J.

    2012-01-01

    The notion of a profiling sensor was first realized by a Near-Infrared (N-IR) retro-reflective prototype consisting of a vertical column of wired sparse detectors. This paper extends that prior work and presents a wireless version of a profiling sensor as a collection of sensor nodes. The sensor incorporates wireless sensing elements, a distributed data collection and aggregation scheme, and an enhanced classification technique. In this novel approach, a base station pre-processes the data collected from the sensor nodes and performs data re-alignment. A back-propagation neural network was also developed for the wireless version of the N-IR profiling sensor that classifies objects into the broad categories of human, animal or vehicle with an accuracy of approximately 94%. These enhancements improve deployment options as compared with the first generation of wired profiling sensors, possibly increasing the application scenarios for such sensors, including intelligent fence applications. PMID:23443371

  17. Advances in Quantum Trajectory Approaches to Dynamics

    NASA Astrophysics Data System (ADS)

    Askar, Attila

    2001-03-01

    The quantum fluid dynamics (QFD) formulation is based on the separation of the amplitude and phase of the complex wave function in Schrodinger's equation. The approach leads to conservation laws for an equivalent "gas continuum". The Lagrangian [1] representation corresponds to following the particles of the fluid continuum, i. e. calculating "quantum trajectories". The Eulerian [2] representation on the other hand, amounts to observing the dynamics of the gas continuum at the points of a fixed coordinate frame. The combination of several factors leads to a most encouraging computational efficiency. QFD enables the numerical analysis to deal with near monotonic amplitude and phase functions. The Lagrangian description concentrates the computation effort to regions of highest probability as an optimal adaptive grid. The Eulerian representation allows the study of multi-coordinate problems as a set of one-dimensional problems within an alternating direction methodology. An explicit time integrator limits the increase in computational effort with the number of discrete points to linear. Discretization of the space via local finite elements [1,2] and global radial functions [3] will be discussed. Applications include wave packets in four-dimensional quadratic potentials and two coordinate photo-dissociation problems for NOCl and NO2. [1] "Quantum fluid dynamics (QFD) in the Lagrangian representation with applications to photo-dissociation problems", F. Sales, A. Askar and H. A. Rabitz, J. Chem. Phys. 11, 2423 (1999) [2] "Multidimensional wave-packet dynamics within the fluid dynamical formulation of the Schrodinger equation", B. Dey, A. Askar and H. A. Rabitz, J. Chem. Phys. 109, 8770 (1998) [3] "Solution of the quantum fluid dynamics equations with radial basis function interpolation", Xu-Guang Hu, Tak-San Ho, H. A. Rabitz and A. Askar, Phys. Rev. E. 61, 5967 (2000)

  18. The magnet measurement facility for the Advanced Photon Source

    SciTech Connect

    Kim, S.H.; Doose, C.; Hogrefe, R.; Kim, K.; Merl, R.

    1993-10-01

    A magnet measurement facility has been developed to measure the prototype and production magnets for the Advance Photon Source. The measurement facility is semi-automatic in measurement control and data analysis. One dipole system and three rotating coil measurement systems for quadrupole and sextupole magnets and corresponding probe coils are described.

  19. Demarcating Advanced Learning Approaches from Methodological and Technological Perspectives

    ERIC Educational Resources Information Center

    Horvath, Imre; Peck, David; Verlinden, Jouke

    2009-01-01

    In the field of design and engineering education, the fast and expansive evolution of information and communication technologies is steadily converting traditional learning approaches into more advanced ones. Facilitated by Broadband (high bandwidth) personal computers, distance learning has developed into web-hosted electronic learning. The…

  20. Advanced Safeguards Approaches for New TRU Fuel Fabrication Facilities

    SciTech Connect

    Durst, Philip C.; Ehinger, Michael H.; Boyer, Brian; Therios, Ike; Bean, Robert; Dougan, A.; Tolk, K.

    2007-12-15

    This second report in a series of three reviews possible safeguards approaches for the new transuranic (TRU) fuel fabrication processes to be deployed at AFCF – specifically, the ceramic TRU (MOX) fuel fabrication line and the metallic (pyroprocessing) line. The most common TRU fuel has been fuel composed of mixed plutonium and uranium dioxide, referred to as “MOX”. However, under the Advanced Fuel Cycle projects custom-made fuels with higher contents of neptunium, americium, and curium may also be produced to evaluate if these “minor actinides” can be effectively burned and transmuted through irradiation in the ABR. A third and final report in this series will evaluate and review the advanced safeguards approach options for the ABR. In reviewing and developing the advanced safeguards approach for the new TRU fuel fabrication processes envisioned for AFCF, the existing international (IAEA) safeguards approach at the Plutonium Fuel Production Facility (PFPF) and the conceptual approach planned for the new J-MOX facility in Japan have been considered as a starting point of reference. The pyro-metallurgical reprocessing and fuel fabrication process at EBR-II near Idaho Falls also provided insight for safeguarding the additional metallic pyroprocessing fuel fabrication line planned for AFCF.

  1. Measuring advances in HVAC distribution system designs

    SciTech Connect

    Franconi, Ellen

    1998-07-01

    Substantial commercial building energy savings have been achieved by improving the performance of the HVAC distribution system. The energy savings result from distribution system design improvements, advanced control capabilities, and use of variable-speed motors. Yet, much of the commercial building stock remains equipped with inefficient systems. Contributing to this is the absence of a definition for distribution system efficiency as well as the analysis methods for quantifying performance. This research investigates the application of performance indices to assess design advancements in commercial building thermal distribution systems. The index definitions are based on a first and second law of thermodynamics analysis of the system. The second law or availability analysis enables the determination of the true efficiency of the system. Availability analysis is a convenient way to make system efficiency comparisons since performance is evaluated relative to an ideal process. A TRNSYS simulation model is developed to analyze the performance of two distribution system types, a constant air volume system and a variable air volume system, that serve one floor of a large office building. Performance indices are calculated using the simulation results to compare the performance of the two systems types in several locations. Changes in index values are compared to changes in plant energy, costs, and carbon emissions to explore the ability of the indices to estimate these quantities.

  2. Measuring Advances in HVAC Distribution System Design

    SciTech Connect

    Franconi, E.

    1998-05-01

    Substantial commercial building energy savings have been achieved by improving the performance of the HV AC distribution system. The energy savings result from distribution system design improvements, advanced control capabilities, and use of variable-speed motors. Yet, much of the commercial building stock remains equipped with inefficient systems. Contributing to this is the absence of a definition for distribution system efficiency as well as the analysis methods for quantifying performance. This research investigates the application of performance indices to assess design advancements in commercial building thermal distribution systems. The index definitions are based on a first and second law of thermodynamics analysis of the system. The second law or availability analysis enables the determination of the true efficiency of the system. Availability analysis is a convenient way to make system efficiency comparisons since performance is evaluated relative to an ideal process. A TRNSYS simulation model is developed to analyze the performance of two distribution system types, a constant air volume system and a variable air volume system, that serve one floor of a large office building. Performance indices are calculated using the simulation results to compare the performance of the two systems types in several locations. Changes in index values are compared to changes in plant energy, costs, and carbon emissions to explore the ability of the indices to estimate these quantities.

  3. Microbial Burden Approach : New Monitoring Approach for Measuring Microbial Burden

    NASA Technical Reports Server (NTRS)

    Venkateswaran, Kasthuri; Vaishampayan, Parag; Barmatz, Martin

    2013-01-01

    Advantages of new approach for differentiating live cells/ spores from dead cells/spores. Four examples of Salmonella outbreaks leading to costly destruction of dairy products. List of possible collaboration activities between JPL and other industries (for future discussion). Limitations of traditional microbial monitoring approaches. Introduction to new approach for rapid measurement of viable (live) bacterial cells/spores and its areas of application. Detailed example for determining live spores using new approach (similar procedure for determining live cells). JPL has developed a patented approach for measuring amount of live and dead cells/spores. This novel "molecular" method takes less than 5 to 7 hrs. compared to the seven days required using conventional techniques. Conventional "molecular" techniques can not discriminate live cells/spores among dead cells/spores. The JPL-developed novel method eliminates false positive results obtained from conventional "molecular" techniques that lead to unnecessary delay in the processing and to unnecessary destruction of food products.

  4. Multidirectional mobilities: Advanced measurement techniques and applications

    NASA Astrophysics Data System (ADS)

    Ivarsson, Lars Holger

    Today high noise-and-vibration comfort has become a quality sign of products in sectors such as the automotive industry, aircraft, components, households and manufacturing. Consequently, already in the design phase of products, tools are required to predict the final vibration and noise levels. These tools have to be applicable over a wide frequency range with sufficient accuracy. During recent decades a variety of tools have been developed such as transfer path analysis (TPA), input force estimation, substructuring, coupling by frequency response functions (FRF) and hybrid modelling. While these methods have a well-developed theoretical basis, their application combined with experimental data often suffers from a lack of information concerning rotational DOFs. In order to measure response in all 6 DOFs (including rotation), a sensor has been developed, whose special features are discussed in the thesis. This transducer simplifies the response measurements, although in practice the excitation of moments appears to be more difficult. Several excitation techniques have been developed to enable measurement of multidirectional mobilities. For rapid and simple measurement of the loaded mobility matrix, a MIMO (Multiple Input Multiple Output) technique is used. The technique has been tested and validated on several structures of different complexity. A second technique for measuring the loaded 6-by-6 mobility matrix has been developed. This technique employs a model of the excitation set-up, and with this model the mobility matrix is determined from sequential measurements. Measurements on ``real'' structures show that both techniques give results of similar quality, and both are recommended for practical use. As a further step, a technique for measuring the unloaded mobilities is presented. It employs the measured loaded mobility matrix in order to calculate compensation forces and moments, which are later applied in order to compensate for the loading of the

  5. Behavioral and Cognitive-Behavioral Approaches to Chronic Pain: Recent Advances and Future Directions.

    ERIC Educational Resources Information Center

    Keefe, Francis J.; And Others

    1992-01-01

    Reviews and highlights recent research advances and future research directions concerned with behavioral and cognitive-behavioral approaches to chronic pain. Reviews assessment research on studies of social context of pain, relationship of chronic pain to depression, cognitive variables affecting pain, and comprehensive assessment measures.…

  6. Whole-genome CNV analysis: advances in computational approaches

    PubMed Central

    Pirooznia, Mehdi; Goes, Fernando S.; Zandi, Peter P.

    2015-01-01

    Accumulating evidence indicates that DNA copy number variation (CNV) is likely to make a significant contribution to human diversity and also play an important role in disease susceptibility. Recent advances in genome sequencing technologies have enabled the characterization of a variety of genomic features, including CNVs. This has led to the development of several bioinformatics approaches to detect CNVs from next-generation sequencing data. Here, we review recent advances in CNV detection from whole genome sequencing. We discuss the informatics approaches and current computational tools that have been developed as well as their strengths and limitations. This review will assist researchers and analysts in choosing the most suitable tools for CNV analysis as well as provide suggestions for new directions in future development. PMID:25918519

  7. Measuring the Resilience of Advanced Life Support Systems

    NASA Technical Reports Server (NTRS)

    Bell, Ann Maria; Dearden, Richard; Levri, Julie A.

    2002-01-01

    Despite the central importance of crew safety in designing and operating a life support system, the metric commonly used to evaluate alternative Advanced Life Support (ALS) technologies does not currently provide explicit techniques for measuring safety. The resilience of a system, or the system s ability to meet performance requirements and recover from component-level faults, is fundamentally a dynamic property. This paper motivates the use of computer models as a tool to understand and improve system resilience throughout the design process. Extensive simulation of a hybrid computational model of a water revitalization subsystem (WRS) with probabilistic, component-level faults provides data about off-nominal behavior of the system. The data can then be used to test alternative measures of resilience as predictors of the system s ability to recover from component-level faults. A novel approach to measuring system resilience using a Markov chain model of performance data is also developed. Results emphasize that resilience depends on the complex interaction of faults, controls, and system dynamics, rather than on simple fault probabilities.

  8. Advances in measuring single-cell pharmacology in vivo.

    PubMed

    Vinegoni, Claudio; Dubach, J Matthew; Thurber, Greg M; Miller, Miles A; Mazitschek, Ralph; Weissleder, Ralph

    2015-09-01

    Measuring key pharmacokinetic and pharmacodynamic parameters in vivo at the single cell level is likely to enhance drug discovery and development. In this review, we summarize recent advances in this field and highlight current and future capabilities. PMID:26024776

  9. Admiralty Inlet Advanced Turbulence Measurements: May 2015

    DOE Data Explorer

    Kilcher, Levi

    2015-05-18

    This data is from measurements at Admiralty Head, in Admiralty Inlet (Puget Sound) in May of 2015. The measurements were made using Inertial Motion Unit (IMU) equipped ADVs mounted on a 'StableMoor' (Manufacturer: DeepWater Buoyancy) buoy and a Tidal Turbulence Mooring (TTM). These platforms position ADV heads above the seafloor to make mid-depth turbulence measurements. The inertial measurements from the IMU allows for removal of mooring motion in post processing. The mooring and buoy motion has been removed from the stream-wise and vertical velocity signals (u, w). The lateral (v) velocity has some 'persistent motion contamination' due to mooring sway. The TTM was deployed with one ADV, it's position was: 48 09.145', -122 41.209' The StableMoor was deployed twice, the first time it was deployed in 'wing-mode' with two ADVs ('Port' and 'Star') at: 48 09.166', -122 41.173' The second StableMoor deployment was in 'Nose' mode with one ADV at: 48 09.166', -122 41.174' Units ----- - Velocity data (_u, urot, uacc) is in m/s. - Acceleration (Accel) data is in m/s^2. - Angular rate (AngRt) data is in rad/s. - The components of all vectors are in 'ENU' orientation. That is, the first index is True East, the second is True North, and the third is Up (vertical). - All other quantities are in the units defined in the Nortek Manual. Motion correction and rotation into the ENU earth reference frame was performed using the Python-based open source DOLfYN library (http://lkilcher.github.io/dolfyn/). Details on motion correction can be found there. Additional details on TTM measurements at this site can be found in the included Marine Energy Technology Symposium paper.

  10. Admiralty Inlet Advanced Turbulence Measurements: June 2014

    DOE Data Explorer

    Kilcher, Levi

    2014-06-30

    This data is from measurements at Admiralty Head, in Admiralty Inlet (Puget Sound) in June of 2014. The measurements were made using Inertial Motion Unit (IMU) equipped ADVs mounted on Tidal Turbulence Mooring's (TTMs). The TTM positions the ADV head above the seafloor to make mid-depth turbulence measurements. The inertial measurements from the IMU allows for removal of mooring motion in post processing. The mooring motion has been removed from the stream-wise and vertical velocity signals (u, w). The lateral (v) velocity has some 'persistent motion contamination' due to mooring sway. Each ttm was deployed with two ADVs. The 'top' ADV head was positioned 0.5m above the 'bottom' ADV head. The TTMs were placed in 58m of water. The position of the TTMs were: ttm01 : (48.1525, -122.6867) ttm01b : (48.15256666, -122.68678333) ttm02b : (48.152783333, -122.686316666) Deployments TTM01b and TTM02b occurred simultaneously and were spaced approximately 50m apart in the cross-stream direction. Units ----- - Velocity data (_u, urot, uacc) is in m/s. - Acceleration (Accel) data is in m/s^2. - Angular rate (AngRt) data is in rad/s. - The components of all vectors are in 'ENU' orientation. That is, the first index is True East, the second is True North, and the third is Up (vertical). - All other quantities are in the units defined in the Nortek Manual. Motion correction and rotation into the ENU earth reference frame was performed using the Python-based open source DOLfYN library (http://lkilcher.github.io/dolfyn/). Details on motion correction can be found there. Additional details on TTM measurements at this site can be found in the included Marine Energy Technology Symposium paper.

  11. A combinatorial approach to the discovery of advanced materials

    NASA Astrophysics Data System (ADS)

    Sun, Xiao-Dong

    This thesis discusses the application of combinatorial methods to the search of advanced materials. The goal of this research is to develop a "parallel" or "fast sequential" methodology for both the synthesis and characterization of materials with novel electronic, magnetic and optical properties. Our hope is to dramatically accelerate the rate at which materials are generated and studied. We have developed two major combinatorial methodologies to this end. One involves generating thin film materials libraries using a combination of various thin film deposition and masking strategies with multi-layer thin film precursors. The second approach is to generate powder materials libraries with solution precursors delivered with a multi-nozzle inkjet system. The first step in this multistep combinatorial process involves the design and synthesis of high density libraries of diverse materials aimed at exploring a large segment of the compositional space of interest based on our understanding of the physical and structural properties of a particular class of materials. Rapid, sensitive measurements of one or more relevant physical properties of each library member result in the identification of a family of "lead" compositions with a desired property. These compositions are then optimized by continuously varying the stoichiometries of a more focused set of precursors. Materials with the optimal composition are then synthesized in quantities sufficient for detailed characterization of their structural and physical properties. Finally, the information obtained from this process should enhance our predictive ability in subsequent experiments. Combinatorial methods have been successfully used in the synthesis and discovery of materials with novel properties. For example, a class of cobaltite based giant magnetoresistance (GMR) ceramics was discovered; Application of this method to luminescence materials has resulted in the discovery of a few highly efficient tricolor

  12. Advance particle and Doppler measurement methods

    NASA Technical Reports Server (NTRS)

    Busch, C.

    1985-01-01

    Particle environments, i.e., rain, ice, and snow particles are discussed. Two types of particles addressed are: (1) the natural environment in which airplanes fly and conduct test flights; and (2) simulation environments that are encountered in ground-test facilities such as wind tunnels, ranges, etc. There are characteristics of the natural environment that one wishes to measure. The liquid water content (LWC) is the one that seems to be of most importance; size distribution may be of importance in some applications. Like snow, the shape of the particle may be an important parameter to measure. As one goes on to environment in simulated tests, additional parameters may be required such as velocity distribution, the velocity lag of the particle relative to the aerodynamic flow, and the trajectory of the particle as it goes through the aerodynamic flow and impacts on the test object.

  13. Advanced giant magnetoresistance technology for measurement applications

    NASA Astrophysics Data System (ADS)

    Weiss, Roland; Mattheis, Roland; Reiss, Günter

    2013-08-01

    Giant magnetoresistance (GMR) sensors are considered one of the first real applications of nanotechnology. They consist of nm-thick layered structures where ferromagnetic metals are sandwiched by nonmagnetic metals. Such multilayered films produce a large change in resistance (typically 10 to 20%) when subjected to a magnetic field, compared with a maximum change of a few per cent for other types of magnetic sensors. This technology has been intensively used in read heads for hard disk drives and now increasingly finds applications due to the high sensitivity and signal-to-noise ratio. Additionally these sensors are compatible with miniaturization and thus offer a high spatial resolution combined with a frequency range up to the 100 MHz regime and simple electronic conditioning. In this review, we first discuss the basics of the underlying magnetoresistance effects in layered structures and then present three prominent examples for future applications: in the field of current sensing the new GMR sensors offer high bandwidth and good accuracy in a space-saving open loop measurement configuration. In rotating systems they can be used for multiturn angle measurements, and in biotechnology the detection of magnetic particles enables the quantitative measurement of biomolecule concentrations.

  14. Advanced (Measurement) Applications of Curriculum-Based Measurement in Reading

    ERIC Educational Resources Information Center

    Petscher, Yaacov; Cummings, Kelli Dawn; Biancarosa, Gina; Fien, Hank

    2013-01-01

    The purpose of this article is to provide a commentary on the current state of several measurement issues pertaining to curriculum-based measures of reading (R-CBM). We begin by providing an overview of the utility of R-CBM, followed by a presentation of five specific measurements considerations: (a) the reliability of R-CBM oral reading fluency…

  15. Advancing Performance Measures for Use of Medications in Substance Abuse Treatment

    PubMed Central

    Garnick, Deborah W.; Horgan, Constance M.; McCorry, Frank; Gmyrek, Amanda; Chalk, Mady; Gastfriend, David; Rinaldo, Suzanne Gelber; Albright, Joann; Capoccia, Victor; Harris, Alex; Harwood, Henrick J.; Greenberg, Pamela; Mark, Tami; Un, Huong; Oros, Marla; Stringer, Mark; Thatcher, James

    2010-01-01

    Performance measures have the potential to drive high quality health care. However, technical and policy challenges exist in developing and implementing measures to assess substance use disorder (SUD) pharmacotherapy. Of critical importance in advancing performance measures for use of SUD pharmacotherapy is recognition that different measurement approaches may be needed in the public and private sectors, and will be determined by the availability of different data collection and monitoring systems. In 2009, the Washington Circle convened a panel of nationally recognized insurers, purchasers, providers, policy makers, and researchers to address this topic. The charge of the panel was to identify opportunities and challenges in advancing use of SUD pharmacotherapy performance measures across a range of systems. This paper summarizes those findings by identifying a number of critical themes related to advancing SUD pharmacotherapy performance measures, highlighting examples from the field, and recommending actions for policy makers. PMID:20934836

  16. Fatigue experience in advanced cancer: a phenomenological approach.

    PubMed

    Potter, Joan

    2004-01-01

    This study describes the experience of fatigue in patients with advanced cancer. A phenomenological approach was adopted to allow a fuller expression of the phenomenon of fatigue in the sample of six patients. Five major themes were identified. These were physical, psychological, social and spiritual consequences of fatigue, and helpful and unhelpful coping strategies. The themes demonstrate the complexity of fatigue, which had an all-encompassing effect on patients' lives. The themes were interconnected and cannot be viewed independently. For these patients with advanced cancer the meaning of fatigue was intertwined with the process of adjusting to living with a terminal illness and ultimately death. It was impossible for them to separate the two. Coping strategies that would normally be of use to fatigued individuals were shown to have little or no benefit. Sensitive communication about fatigue and its meaning to the patient may assist adjustment and generate hope.

  17. Science based integrated approach to advanced nuclear fuel development - vision, approach, and overview

    SciTech Connect

    Unal, Cetin; Pasamehmetoglu, Kemal; Carmack, Jon

    2010-01-01

    Advancing the performance of Light Water Reactors, Advanced Nuclear Fuel Cycles, and Advanced Rcactors, such as the Next Generation Nuclear Power Plants, requires enhancing our fundamental understanding of fuel and materials behavior under irradiation. The capability to accurately model the nuclear fuel systems is critical. In order to understand specific aspects of the nuclear fuel, fully coupled fuel simulation codes are required to achieve licensing of specific nuclear fuel designs for operation. The backbone of these codes, models, and simulations is a fundamental understanding and predictive capability for simulating the phase and microstructural behavior of the nuclear fuel system materials and matrices. The purpose of this paper is to identify the modeling and simulation approach in order to deliver predictive tools for advanced fuels development. The coordination between experimental nuclear fuel design, development technical experts, and computational fuel modeling and simulation technical experts is a critical aspect of the approach and naturally leads to an integrated, goal-oriented science-based R & D approach and strengthens both the experimental and computational efforts. The Advanced Fuels Campaign (AFC) and Nuclear Energy Advanced Modeling and Simulation (NEAMS) Fuels Integrated Performance and Safety Code (IPSC) are working together to determine experimental data and modeling needs. The primary objective of the NEAMS fuels IPSC project is to deliver a coupled, three-dimensional, predictive computational platform for modeling the fabrication and both normal and abnormal operation of nuclear fuel pins and assemblies, applicable to both existing and future reactor fuel designs. The science based program is pursuing the development of an integrated multi-scale and multi-physics modeling and simulation platform for nuclear fuels. This overview paper discusses the vision, goals and approaches how to develop and implement the new approach.

  18. Measurement and modeling of advanced coal conversion processes

    SciTech Connect

    Solomon, P.R.; Serio, M.A.; Hamblen, D.G.; Smoot, L.D.; Brewster, B.S. Brigham Young Univ., Provo, UT )

    1991-01-01

    The overall objective of this program is the development of predictive capability for the design, scale up, simulation, control and feedstock evaluation in advanced coal conversion devices. This program will merge significant advances made in measuring and quantitatively describing the mechanisms in coal conversion behavior. Comprehensive computer codes for mechanistic modeling of entrained-bed gasification. Additional capabilities in predicting pollutant formation will be implemented and the technology will be expanded to fixed-bed reactors.

  19. 76 FR 52954 - Workshop: Advancing Research on Mixtures; New Perspectives and Approaches for Predicting Adverse...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Workshop: Advancing Research on Mixtures; New Perspectives and Approaches for Predicting... ``Advancing Research on Mixtures: New Perspectives and Approaches for Predicting Adverse Human Health...

  20. Flow measurements in semiconductor processing; New advances in measurement technology

    NASA Astrophysics Data System (ADS)

    Tison, S. A.; Calabrese, A. M.

    1998-11-01

    Gas flow measurement, control, and distribution are an integral part in meeting present and future semiconductor processing requirements (1). Changes in processing and environmental concerns have put additional pressure not only on accurate measurement of the gas flow, but also in reducing flows. To address the need for more accurate metering of gas flows, NIST has developed primary flow standards which have uncertainties of 0.1% of reading or better over the flow range of 10-9 mol/s to 10-3 mol/s (0.001 sccm to 1000 sccm). These standards have been used to test NIST-designed high repeatability flow transfer standards (2) which can be used to document and improve flow measurements in the semiconductor industry (3). In particular two flowmeters have been developed at NIST; the first is a pressure-based flow sensor and the second a Doppler-shift flowmeter, both of which can be used for in-situ calibration of thermal mass flow controllers or for direct metering of process gases.

  1. Technical approaches for measurement of human errors

    NASA Technical Reports Server (NTRS)

    Clement, W. F.; Heffley, R. K.; Jewell, W. F.; Mcruer, D. T.

    1980-01-01

    Human error is a significant contributing factor in a very high proportion of civil transport, general aviation, and rotorcraft accidents. The technical details of a variety of proven approaches for the measurement of human errors in the context of the national airspace system are presented. Unobtrusive measurements suitable for cockpit operations and procedures in part of full mission simulation are emphasized. Procedure, system performance, and human operator centered measurements are discussed as they apply to the manual control, communication, supervisory, and monitoring tasks which are relevant to aviation operations.

  2. Recent advances in optical measurement methods in physics and chemistry

    SciTech Connect

    Gerardo, J.B.

    1985-01-01

    Progress being made in the development of new scientific measurement tools based on optics and the scientific advances made possible by these new tools is impressive. In some instances, new optical-based measurement methods have made new scientific studies possible, while in other instances they have offered an improved method for performing these studies, e.g., better signal-to-noise ratio, increased data acquisition rate, remote analysis, reduced perturbation to the physical or chemical system being studied, etc. Many of these advances were made possible by advances in laser technology - spectral purity, spectral brightness, tunability, ultrashort pulse width, amplitude stability, etc. - while others were made possible by improved optical components - single-made fibers, modulators, detectors, wavelength multiplexes, etc. Attention is limited to just a few of many such accomplishments made recently at Sandia. 17 references, 16 figures.

  3. Measuring segregation: an activity space approach.

    PubMed

    Wong, David W S; Shaw, Shih-Lung

    2011-06-01

    While the literature clearly acknowledges that individuals may experience different levels of segregation across their various socio-geographical spaces, most measures of segregation are intended to be used in the residential space. Using spatially aggregated data to evaluate segregation in the residential space has been the norm and thus individual's segregation experiences in other socio-geographical spaces are often de-emphasized or ignored. This paper attempts to provide a more comprehensive approach in evaluating segregation beyond the residential space. The entire activity spaces of individuals are taken into account with individuals serving as the building blocks of the analysis. The measurement principle is based upon the exposure dimension of segregation. The proposed measure reflects the exposure of individuals of a referenced group in a neighborhood to the populations of other groups that are found within the activity spaces of individuals in the referenced group. Using the travel diary data collected from the tri-county area in southeast Florida and the imputed racial-ethnic data, this paper demonstrates how the proposed segregation measurement approach goes beyond just measuring population distribution patterns in the residential space and can provide a more comprehensive evaluation of segregation by considering various socio-geographical spaces.

  4. Measuring segregation: an activity space approach

    PubMed Central

    Shaw, Shih-Lung

    2010-01-01

    While the literature clearly acknowledges that individuals may experience different levels of segregation across their various socio-geographical spaces, most measures of segregation are intended to be used in the residential space. Using spatially aggregated data to evaluate segregation in the residential space has been the norm and thus individual’s segregation experiences in other socio-geographical spaces are often de-emphasized or ignored. This paper attempts to provide a more comprehensive approach in evaluating segregation beyond the residential space. The entire activity spaces of individuals are taken into account with individuals serving as the building blocks of the analysis. The measurement principle is based upon the exposure dimension of segregation. The proposed measure reflects the exposure of individuals of a referenced group in a neighborhood to the populations of other groups that are found within the activity spaces of individuals in the referenced group. Using the travel diary data collected from the tri-county area in southeast Florida and the imputed racial–ethnic data, this paper demonstrates how the proposed segregation measurement approach goes beyond just measuring population distribution patterns in the residential space and can provide a more comprehensive evaluation of segregation by considering various socio-geographical spaces. PMID:21643546

  5. An Approach to Measuring Software Quality Perception

    NASA Astrophysics Data System (ADS)

    Hofman, Radoslaw

    Perception measuring and perception management is an emerging approach in the area of product management. Cognitive, psychological, behavioral and neurological theories, tools and methods are being employed for a better understanding of the mechanisms of a consumer's attitude and decision processes. Software is also being defined as a product, however this kind of product is significantly different from all other products. Software products are intangible and it is difficult to trace their characteristics which are strongly dependant on a dynamic context of use.

  6. Human-centred approaches in slipperiness measurement

    PubMed Central

    Grönqvist, Raoul; Abeysekera, John; Gard, Gunvor; Hsiang, Simon M.; Leamon, Tom B.; Newman, Dava J.; Gielo-Perczak, Krystyna; Lockhart, Thurmon E.; Pai, Clive Y.-C.

    2010-01-01

    A number of human-centred methodologies—subjective, objective, and combined—are used for slipperiness measurement. They comprise a variety of approaches from biomechanically-oriented experiments to psychophysical tests and subjective evaluations. The objective of this paper is to review some of the research done in the field, including such topics as awareness and perception of slipperiness, postural and balance control, rating scales for balance, adaptation to slippery conditions, measurement of unexpected movements, kinematics of slipping, and protective movements during falling. The role of human factors in slips and falls will be discussed. Strengths and weaknesses of human-centred approaches in relation to mechanical slip test methodologies are considered. Current friction-based criteria and thresholds for walking without slipping are reviewed for a number of work tasks. These include activities such as walking on a level or an inclined surface, running, stopping and jumping, as well as stair ascent and descent, manual exertion (pushing and pulling, load carrying, lifting) and particular concerns of the elderly and mobility disabled persons. Some future directions for slipperiness measurement and research in the field of slips and falls are outlined. Human-centred approaches for slipperiness measurement do have many applications. First, they are utilized to develop research hypotheses and models to predict workplace risks caused by slipping. Second, they are important alternatives to apparatus-based friction measurements and are used to validate such methodologies. Third, they are used as practical tools for evaluating and monitoring slip resistance properties of foot wear, anti-skid devices and floor surfaces. PMID:11794763

  7. Reliability Demonstration Approach for Advanced Stirling Radioisotope Generator

    NASA Technical Reports Server (NTRS)

    Ha, CHuong; Zampino, Edward; Penswick, Barry; Spronz, Michael

    2010-01-01

    Developed for future space missions as a high-efficiency power system, the Advanced Stirling Radioisotope Generator (ASRG) has a design life requirement of 14 yr in space following a potential storage of 3 yr after fueling. In general, the demonstration of long-life dynamic systems remains difficult in part due to the perception that the wearout of moving parts cannot be minimized, and associated failures are unpredictable. This paper shows a combination of systematic analytical methods, extensive experience gained from technology development, and well-planned tests can be used to ensure a high level reliability of ASRG. With this approach, all potential risks from each life phase of the system are evaluated and the mitigation adequately addressed. This paper also provides a summary of important test results obtained to date for ASRG and the planned effort for system-level extended operation.

  8. A Novel Approach to Material Development for Advanced Reactor Systems

    SciTech Connect

    Was, G.S.; Atzmon, M.; Wang, L.

    1999-12-22

    OAK B188 A Novel Approach to Material Development for Advanced Reactor Systems. Year one of this project had three major goals. First, to specify, order and install a new high current ion source for more rapid and stable proton irradiation. Second, to assess the use low temperature irradiation and chromium pre-enrichment in an effort to isolate a radiation damage microstructure in stainless steels without the effects of RIS. Third, to prepare for the irradiation of reactor pressure vessel steel and Zircaloy. In year 1 quarter 1, the project goal was to order the high current ion source and to procure and prepare samples of stainless steel for low temperature proton irradiation.

  9. A Novel Approach to Material Development for Advanced Reactor Systems

    SciTech Connect

    Was, G.S.; Atzmon, M.; Wang, L.

    2000-06-27

    OAK B188 A Novel Approach to Material Development for Advanced Reactor Systems. Year one of this project had three major goals. First, to specify, order and install a new high current ion source for more rapid and stable proton irradiation. Second, to assess the use of low temperature irradiation and chromium pre-enrichment in an effort to isolate a radiation damage microstructure in stainless steel without the effects of RIS. Third, to initiate irradiation of reactor pressure vessel steel and Zircaloy. In year 1 quarter 3, the project goal was to complete irradiation of model alloys of RPV steels for a range of doses and begin sample characterization. We also planned to prepare samples for microstructure isolation in stainless steels, and to identify sources of Zircaloy for irradiation and characterization.

  10. Advanced Microgravity Acceleration Measurement Systems (AMAMS) Being Developed

    NASA Technical Reports Server (NTRS)

    Sicker, Ronald J.; Kacpura, Thomas J.

    2003-01-01

    The Advanced Microgravity Acceleration Measurement Systems (AMAMS) project is part of NASA s Instrument Technology Development program to develop advanced sensor systems. The primary focus of the AMAMS project is to develop microelectromechanical systems (MEMS) for acceleration sensor systems to replace existing electromechanical sensor systems presently used to assess relative gravity levels aboard spacecraft. These systems are used to characterize both vehicle and payload responses to low-gravity vibroacoustic environments. The collection of microgravity acceleration data is useful to the microgravity life sciences, microgravity physical sciences, and structural dynamics communities. The inherent advantages of semiconductor-based systems are reduced size, mass, and power consumption, with enhanced long-term calibration stability.

  11. A new approach to measuring tortuosity

    NASA Astrophysics Data System (ADS)

    Wert, Amanda; Scott, Sherry E.

    2012-03-01

    The detection and measurement of the tortuosity - i.e. the bending and winding - of vessels has been shown to be potentially useful in the assessment of cancer progression and treatment response. Although several metrics for tortuosity are used, no single one measure is able to capture all types of tortuosity. This report presents a new multiscale technique for measuring vessel tortuosity. The approach is based on a method - called the ergodicity defect - which gives a scale-dependent measure of deviation from ergodicity. Ergodicity is a concept that captures the manner in which trajectories or signals sample the space; thus, ergodicity and vessel tortuosity both involve the notion of how a signal samples space. Here we begin to explore this connection. We first apply the ergodicity defect tortuosity measure to both 2D and 3D synthetic data in order to demonstrate the response of the method to three types of tortuosity observed in clinical patterns. We then implement the technique on segmented vessels extracted from brain tumor MRA images. Results indicate that the method can be effectively used to detect and measure several types of vessel tortuosity.

  12. Lung volume reduction for advanced emphysema: surgical and bronchoscopic approaches.

    PubMed

    Tidwell, Sherry L; Westfall, Elizabeth; Dransfield, Mark T

    2012-01-01

    Chronic obstructive pulmonary disease is the third leading cause of death in the United States, affecting more than 24 million people. Inhaled bronchodilators are the mainstay of therapy; they improve symptoms and quality of life and reduce exacerbations. These and smoking cessation and long-term oxygen therapy for hypoxemic patients are the only medical treatments definitively demonstrated to reduce mortality. Surgical approaches include lung transplantation and lung volume reduction and the latter has been shown to improve exercise tolerance, quality of life, and survival in highly selected patients with advanced emphysema. Lung volume reduction surgery results in clinical benefits. The procedure is associated with a short-term risk of mortality and a more significant risk of cardiac and pulmonary perioperative complications. Interest has been growing in the use of noninvasive, bronchoscopic methods to address the pathological hyperinflation that drives the dyspnea and exercise intolerance that is characteristic of emphysema. In this review, the mechanism by which lung volume reduction improves pulmonary function is outlined, along with the risks and benefits of the traditional surgical approach. In addition, the emerging bronchoscopic techniques for lung volume reduction are introduced and recent clinical trials examining their efficacy are summarized. PMID:22189668

  13. Approaches to measuring entanglement in chemical magnetometers.

    PubMed

    Tiersch, M; Guerreschi, G G; Clausen, J; Briegel, H J

    2014-01-01

    Chemical magnetometers are radical pair systems such as solutions of pyrene and N,N-dimethylaniline (Py-DMA) that show magnetic field effects in their spin dynamics and their fluorescence. We investigate the existence and decay of quantum entanglement in free geminate Py-DMA radical pairs and discuss how entanglement can be assessed in these systems. We provide an entanglement witness and propose possible observables for experimentally estimating entanglement in radical pair systems with isotropic hyperfine couplings. As an application, we analyze how the field dependence of the entanglement lifetime in Py-DMA could in principle be used for magnetometry and illustrate the propagation of measurement errors in this approach.

  14. Landing approach airframe noise measurements and analysis

    NASA Technical Reports Server (NTRS)

    Lasagna, P. L.; Mackall, K. G.; Burcham, F. W., Jr.; Putnam, T. W.

    1980-01-01

    Flyover measurements of the airframe noise produced by the AeroCommander, JetStar, CV-990, and B-747 airplanes are presented for various landing approach configurations. Empirical and semiempirical techniques are presented to correlate the measured airframe noise with airplane design and aerodynamic parameters. Airframe noise for the jet-powered airplanes in the clean configuration (flaps and gear retracted) was found to be adequately represented by a function of airplane weight and the fifth power of airspeed. Results show the airframe noise for all four aircraft in the landing configuration (flaps extended and gear down) also varied with the fifth power of airspeed, but this noise level could not be represented by the addition of a constant to the equation for clean-configuration airframe noise.

  15. Photothermal cathode measurements at the Advanced Photon Source.

    SciTech Connect

    Sun, Y.-E.; Lewellen, J. W.; Feldman, D. W.; Univ. of Maryland

    2006-01-01

    The Advanced Photon Source (APS) ballistic bunch compression (BBC) gun in the Injector Test Stand (ITS) presently uses an M-type thermionic dispenser cathode as a photocathode. This photothermal cathode offers substantial advantages over conventional metal photocathodes, including easy replacement and easy cleaning via the cathode's built-in heater. We present the results of photoemission measurements as a function of cathode heater power, laser pulse energy, and applied rf field strength.

  16. Advances in Non-Contact Measurement of Creep Properties

    NASA Technical Reports Server (NTRS)

    Hyers, Robert; Canepari, Stacy; White, Erica Bischoff; Cretegny, Laurent; Rogers, jan

    2009-01-01

    As the required service temperatures for superalloys increases, so do the demands on testing for development of these alloys. Non-contact measurement of creep of refractory metals using electrostatic levitation has been demonstrated at temperatures up to 2300 C using samples of only 20-40 mg. These measurements load the spherical specimen by inertial forces due to rapid rotation. However, the first measurements relied on photon pressure to accelerate the samples to the high rotational rates of thousands of rotations per second, limiting the applicability to low stresses and high temperatures. Recent advances in this area extend this measurement to higher stresses and lower-temperatures through the use of an induction motor to drive the sample to such high rotational speeds. Preliminary results on new measurements on new materials will be presented.

  17. A Challenging Surgical Approach to Locally Advanced Primary Urethral Carcinoma

    PubMed Central

    Lucarelli, Giuseppe; Spilotros, Marco; Vavallo, Antonio; Palazzo, Silvano; Miacola, Carlos; Forte, Saverio; Matera, Matteo; Campagna, Marcello; Colamonico, Ottavio; Schiralli, Francesco; Sebastiani, Francesco; Di Cosmo, Federica; Bettocchi, Carlo; Di Lorenzo, Giuseppe; Buonerba, Carlo; Vincenti, Leonardo; Ludovico, Giuseppe; Ditonno, Pasquale; Battaglia, Michele

    2016-01-01

    Abstract Primary urethral carcinoma (PUC) is a rare and aggressive cancer, often underdetected and consequently unsatisfactorily treated. We report a case of advanced PUC, surgically treated with combined approaches. A 47-year-old man underwent transurethral resection of a urethral lesion with histological evidence of a poorly differentiated squamous cancer of the bulbomembranous urethra. Computed tomography (CT) and bone scans excluded metastatic spread of the disease but showed involvement of both corpora cavernosa (cT3N0M0). A radical surgical approach was advised, but the patient refused this and opted for chemotherapy. After 17 months the patient was referred to our department due to the evidence of a fistula in the scrotal area. CT scan showed bilateral metastatic disease in the inguinal, external iliac, and obturator lymph nodes as well as the involvement of both corpora cavernosa. Additionally, a fistula originating from the right corpus cavernosum extended to the scrotal skin. At this stage, the patient accepted the surgical treatment, consisting of different phases. Phase I: Radical extraperitoneal cystoprostatectomy with iliac-obturator lymph nodes dissection. Phase II: Creation of a urinary diversion through a Bricker ileal conduit. Phase III: Repositioning of the patient in lithotomic position for an overturned Y skin incision, total penectomy, fistula excision, and “en bloc” removal of surgical specimens including the bladder, through the perineal breach. Phase IV: Right inguinal lymphadenectomy. The procedure lasted 9-and-a-half hours, was complication-free, and intraoperative blood loss was 600 mL. The patient was discharged 8 days after surgery. Pathological examination documented a T4N2M0 tumor. The clinical situation was stable during the first 3 months postoperatively but then metastatic spread occurred, not responsive to adjuvant chemotherapy, which led to the patient's death 6 months after surgery. Patients with advanced stage tumors of

  18. A Trait-Based Approach to Advance Coral Reef Science.

    PubMed

    Madin, Joshua S; Hoogenboom, Mia O; Connolly, Sean R; Darling, Emily S; Falster, Daniel S; Huang, Danwei; Keith, Sally A; Mizerek, Toni; Pandolfi, John M; Putnam, Hollie M; Baird, Andrew H

    2016-06-01

    Coral reefs are biologically diverse and ecologically complex ecosystems constructed by stony corals. Despite decades of research, basic coral population biology and community ecology questions remain. Quantifying trait variation among species can help resolve these questions, but progress has been hampered by a paucity of trait data for the many, often rare, species and by a reliance on nonquantitative approaches. Therefore, we propose filling data gaps by prioritizing traits that are easy to measure, estimating key traits for species with missing data, and identifying 'supertraits' that capture a large amount of variation for a range of biological and ecological processes. Such an approach can accelerate our understanding of coral ecology and our ability to protect critically threatened global ecosystems. PMID:26969335

  19. Organic and inorganic nitrogen dynamics in soil - advanced Ntrace approach

    NASA Astrophysics Data System (ADS)

    Andresen, Louise C.; Björsne, Anna-Karin; Bodé, Samuel; Klemedtsson, Leif; Boeckx, Pascal; Rütting, Tobias

    2016-04-01

    Depolymerization of soil organic nitrogen (SON) into monomers (e.g. amino acids) is currently thought to be the rate limiting step for the terrestrial nitrogen (N) cycle. The production of free amino acids (AA) is followed by AA mineralization to ammonium, which is an important fraction of the total N mineralization. Accurate assessment of depolymerization and AA mineralization rate is important for a better understanding of the rate limiting steps. Recent developments in the 15N pool dilution techniques, based on 15N labelling of AA's, allow quantifying gross rates of SON depolymerization and AA mineralization (Wanek et al., 2010; Andersen et al., 2015) in addition to gross N mineralization. However, it is well known that the 15N pool dilution approach has limitations; in particular that gross rates of consumption processes (e.g. AA mineralization) are overestimated. This has consequences for evaluating the rate limiting step of the N cycle, as well as for estimating the nitrogen use efficiency (NUE). Here we present a novel 15N tracing approach, which combines 15N-AA labelling with an advanced version of the 15N tracing model Ntrace (Müller et al., 2007) explicitly accounting for AA turnover in soil. This approach (1) provides a more robust quantification of gross depolymerization and AA mineralization and (2) suggests a more realistic estimate for the microbial NUE of amino acids. Advantages of the new 15N tracing approach will be discussed and further improvements will be identified. References: Andresen, L.C., Bodé, S., Tietema, A., Boeckx, P., and Rütting, T.: Amino acid and N mineralization dynamics in heathland soil after long-term warming and repetitive drought, SOIL, 1, 341-349, 2015. Müller, C., Rütting, T., Kattge, J., Laughlin, R. J., and Stevens, R. J.: Estimation of parameters in complex 15N tracing models via Monte Carlo sampling, Soil Biology & Biochemistry, 39, 715-726, 2007. Wanek, W., Mooshammer, M., Blöchl, A., Hanreich, A., and Richter

  20. Voice measures of workload in the advanced flight deck

    NASA Technical Reports Server (NTRS)

    Schneider, Sid J.; Alpert, Murray; Odonnell, Richard

    1989-01-01

    Voice samples were obtained from 14 male subjects under high and low workload conditions. Acoustical analysis of the voice suggested that high workload conditions can be revealed by their effects on the voice over time. Aircrews in the advanced flight deck will be voicing short, imperative sentences repeatedly. A drop in the energy of the voice, as reflected by reductions in amplitude and frequency over time, and the failure to achieve old amplitude and frequency levels after rest periods, can signal that the workload demands of the situation are straining the speaker. This kind of measurement would be relatively unaffected by individual differences in acoustical measures.

  1. Measuring patient-reported outcomes in advanced gastric cancer

    PubMed Central

    Xu, Jianming; Evans, TR Jeffry; Coon, Cheryl; Copley-Merriman, Kati; Su, Yun

    2013-01-01

    Background Gastric cancer (GC), one of the most common cancers in the world, is often diagnosed at an advanced stage and associated with a poor prognosis. Quality of life and patient-reported outcomes (PROs) are important considerations when treating GC patients. The aim of this study was to identify existing PRO instruments that would be appropriate for use in GC trials. Methods Data were obtained from a systematic literature review and interviews with clinical experts. A literature search was conducted using OVID (EMBASE and MEDLINE) and yielded 1,008 abstracts; 92 assessed PROs in an advanced GC. Results Key symptoms and functional impacts identified through the literature and expert input included abdominal pain or pain at the site of distant metastases, dysphagia and other symptoms related to eating, and digestive symptoms. The liver and lungs were the most frequent locations of metastases, leading to dyspnea, abdominal fullness, and jaundice. Symptoms related to changes in bowel habits appeared to be more frequent and pronounced in Asian patients, possibly due to the higher prevalence of GC in the body of the stomach in this population. The five most commonly used PRO instruments were identified, but their validity in advanced-stage GC patients remains unclear. Conclusions The symptoms and functional impacts identified here should be confirmed with robust input from advanced-stage GC patients. Optimal measurement of PROs in GC should account for patient burden and possible differences between Asian and non-Asian patients. PMID:24062809

  2. Oxidative Stress in Aging: Advances in Proteomic Approaches

    PubMed Central

    Ortuño-Sahagún, Daniel; Pallàs, Mercè; Rojas-Mayorquín, Argelia E.

    2014-01-01

    Aging is a gradual, complex process in which cells, tissues, organs, and the whole organism itself deteriorate in a progressive and irreversible manner that, in the majority of cases, implies pathological conditions that affect the individual's Quality of Life (QOL). Although extensive research efforts in recent years have been made, the anticipation of aging and prophylactic or treatment strategies continue to experience major limitations. In this review, the focus is essentially on the compilation of the advances generated by cellular expression profile analysis through proteomics studies (two-dimensional [2D] electrophoresis and mass spectrometry [MS]), which are currently used as an integral approach to study the aging process. Additionally, the relevance of the oxidative stress factors is discussed. Emphasis is placed on postmitotic tissues, such as neuronal, muscular, and red blood cells, which appear to be those most frequently studied with respect to aging. Additionally, models for the study of aging are discussed in a number of organisms, such as Caenorhabditis elegans, senescence-accelerated probe-8 mice (SAMP8), naked mole-rat (Heterocephalus glaber), and the beagle canine. Proteomic studies in specific tissues and organisms have revealed the extensive involvement of reactive oxygen species (ROS) and oxidative stress in aging. PMID:24688629

  3. Oxidative stress in aging: advances in proteomic approaches.

    PubMed

    Ortuño-Sahagún, Daniel; Pallàs, Mercè; Rojas-Mayorquín, Argelia E

    2014-01-01

    Aging is a gradual, complex process in which cells, tissues, organs, and the whole organism itself deteriorate in a progressive and irreversible manner that, in the majority of cases, implies pathological conditions that affect the individual's Quality of Life (QOL). Although extensive research efforts in recent years have been made, the anticipation of aging and prophylactic or treatment strategies continue to experience major limitations. In this review, the focus is essentially on the compilation of the advances generated by cellular expression profile analysis through proteomics studies (two-dimensional [2D] electrophoresis and mass spectrometry [MS]), which are currently used as an integral approach to study the aging process. Additionally, the relevance of the oxidative stress factors is discussed. Emphasis is placed on postmitotic tissues, such as neuronal, muscular, and red blood cells, which appear to be those most frequently studied with respect to aging. Additionally, models for the study of aging are discussed in a number of organisms, such as Caenorhabditis elegans, senescence-accelerated probe-8 mice (SAMP8), naked mole-rat (Heterocephalus glaber), and the beagle canine. Proteomic studies in specific tissues and organisms have revealed the extensive involvement of reactive oxygen species (ROS) and oxidative stress in aging.

  4. Estimation of base station position using timing advance measurements

    NASA Astrophysics Data System (ADS)

    Raitoharju, Matti; Ali-Löytty, Simo; Wirola, Lauri

    2011-10-01

    Timing Advance is used in TDMA (Time Division Multiple Access) systems, such as GSM and LTE, to synchronize the mobile phone to the cellular BS (Base Station). Mobile phone positioning can use TA measurements if BS positions are known, but in many cases BS positions are not in the public domain. In this work we study how to use a set of TA measurements taken by mobile phones at known positions to estimate the position of a BS. This paper describes two methods -- GMF (Gaussian Mixture Filter) and PMF (Point Mass Filter) for estimation of the BS position. Positioning performance is evaluated using simulated and real measurements. In suburban field tests, TA measurements suffice to determine BS position with an error comparable to the TA granularity (550m). GMF computes BS position much faster than PMF and is only slightly less accurate.

  5. Advances in optical property measurements of spacecraft materials

    NASA Technical Reports Server (NTRS)

    Smith, Charles A.; Dever, Joyce A.; Jaworske, Donald A.

    1997-01-01

    Some of the instruments and experimental approaches, used for measuring the optical properties of thermal control systems, are presented. The instruments' use in studies concerning the effects of combined contaminants and space environment on these materials, and in the qualification of hardware for spacecraft, are described. Instruments for measuring the solar absorptance and infrared emittance offer improved speed, accuracy and data handling. A transient method for directly measuring material infrared emittance is described. It is shown that oxygen exposure before measuring the solar absorptance should be avoided.

  6. Advanced Measurement Devices for the Microgravity Electromagnetic Levitation Facility EML

    NASA Technical Reports Server (NTRS)

    Brillo, Jurgen; Fritze, Holger; Lohofer, Georg; Schulz, Michal; Stenzel, Christian

    2012-01-01

    This paper reports on two advanced measurement devices for the microgravity electromagnetic levitation facility (EML), which is currently under construction for the use onboard the "International Space Station (ISS)": the "Sample Coupling Electronics (SCE)" and the "Oxygen Sensing and Control Unit (OSC)". The SCE measures by a contactless, inductive method the electrical resistivity and the diameter of a spherical levitated metallic droplet by evaluating the voltage and electrical current applied to the levitation coil. The necessity of the OSC comes from the insight that properties like surface tension or, eventually, viscosity cannot seriously be determined by the oscillating drop method in the EML facility without knowing the conditions of the surrounding atmosphere. In the following both measurement devices are explained and laboratory test results are presented.

  7. Advances in measuring ocean salinity with an optical sensor

    NASA Astrophysics Data System (ADS)

    Le Menn, M.; de Bougrenet de la Tocnaye, J. L.; Grosso, P.; Delauney, L.; Podeur, C.; Brault, P.; Guillerme, O.

    2011-11-01

    Absolute salinity measurement of seawater has become a key issue in thermodynamic models of the oceans. One of the most direct ways is to measure the seawater refractive index which is related to density and can therefore be related to the absolute salinity. Recent advances in high resolution position sensitive devices enable us to take advantage of small beam deviation measurements using refractometers. This paper assesses the advantages of such technology with respect to the current state-of-the-art technology. In particular, we present the resolution dependence on refractive index variations and derive the limits of such a solution for designing seawater sensors well suited for coastal and deep-sea applications. Particular attention has been paid to investigate the impact of environmental parameters, such as temperature and pressure, on an optical sensor, and ways to mitigate or compensate them have been suggested here. The sensor has been successfully tested in a pressure tank and in open oceans 2000 m deep.

  8. Systems Thinking: An Approach for Advancing Workplace Information Literacy

    ERIC Educational Resources Information Center

    Somerville, Mary M.; Howard, Zaana

    2008-01-01

    As the importance of information literacy has gained increased recognition, so too have academic library professionals intensified their efforts to champion, activate, and advance these capabilities in others. To date, however, little attention has focused on advancing these essential competencies amongst practitioner advocates. This paper helps…

  9. Evolving Approaches to Patients with Advanced Differentiated Thyroid Cancer

    PubMed Central

    Sherman, Steven I.

    2013-01-01

    Advanced differentiated thyroid cancer (DTC), defined by clinical characteristics including gross extrathyroidal invasion, distant metastases, radioiodine (RAI) resistance, and avidity for 18-fluorodeoxyglucose (positron emission tomography-positive), is found in approximately 10–20% of patients with DTC. Standard therapy (surgery, RAI, TSH suppression with levothyroxine) is ineffective for many of these patients, as is standard chemotherapy. Our understanding of the molecular mechanisms leading to DTC and the transformation to advanced DTC has rapidly evolved over the past 15–20 years. Newer targeted therapy, specifically inhibitors of intracellular kinase signaling pathways, and cooperative multicenter clinical trials have dramatically changed the therapeutic landscape for patients with advanced DTC. In this review focusing on morbidities, molecules, and medicinals, we present a patient with advanced DTC, explore the genetics and molecular biology of advanced DTC, and review evolving therapies for these patients including multikinase inhibitors, selective kinase inhibitors, and combination therapies. PMID:23575762

  10. Sleepwalking Into Infertility: The Need for a Public Health Approach Toward Advanced Maternal Age.

    PubMed

    Lemoine, Marie-Eve; Ravitsky, Vardit

    2015-01-01

    In Western countries today, a growing number of women delay motherhood until their late 30s and even 40s, as they invest time in pursuing education and career goals before starting a family. This social trend results from greater gender equality and expanded opportunities for women and is influenced by the availability of contraception and assisted reproductive technologies (ART). However, advanced maternal age is associated with increased health risks, including infertility. While individual medical solutions such as ART and elective egg freezing can promote reproductive autonomy, they entail significant risks and limitations. We thus argue that women should be better informed regarding the risks of advanced maternal age and ART, and that these individual solutions need to be supplemented by a public health approach, including policy measures that provide women with the opportunity to start a family earlier in life without sacrificing personal career goals. PMID:26575814

  11. Sleepwalking Into Infertility: The Need for a Public Health Approach Toward Advanced Maternal Age.

    PubMed

    Lemoine, Marie-Eve; Ravitsky, Vardit

    2015-01-01

    In Western countries today, a growing number of women delay motherhood until their late 30s and even 40s, as they invest time in pursuing education and career goals before starting a family. This social trend results from greater gender equality and expanded opportunities for women and is influenced by the availability of contraception and assisted reproductive technologies (ART). However, advanced maternal age is associated with increased health risks, including infertility. While individual medical solutions such as ART and elective egg freezing can promote reproductive autonomy, they entail significant risks and limitations. We thus argue that women should be better informed regarding the risks of advanced maternal age and ART, and that these individual solutions need to be supplemented by a public health approach, including policy measures that provide women with the opportunity to start a family earlier in life without sacrificing personal career goals.

  12. Advancing understanding of executive function impairments and psychopathology: bridging the gap between clinical and cognitive approaches

    PubMed Central

    Snyder, Hannah R.; Miyake, Akira; Hankin, Benjamin L.

    2015-01-01

    Executive function (EF) is essential for successfully navigating nearly all of our daily activities. Of critical importance for clinical psychological science, EF impairments are associated with most forms of psychopathology. However, despite the proliferation of research on EF in clinical populations, with notable exceptions clinical and cognitive approaches to EF have remained largely independent, leading to failures to apply theoretical and methodological advances in one field to the other field and hindering progress. First, we review the current state of knowledge of EF impairments associated with psychopathology and limitations to the previous research in light of recent advances in understanding and measuring EF. Next, we offer concrete suggestions for improving EF assessment. Last, we suggest future directions, including integrating modern models of EF with state of the art, hierarchical models of dimensional psychopathology as well as translational implications of EF-informed research on clinical science. PMID:25859234

  13. Advanced Measurements of Silicon Carbide Ceramic Matrix Composites

    SciTech Connect

    Farhad Farzbod; Stephen J. Reese; Zilong Hua; Marat Khafizov; David H. Hurley

    2012-08-01

    Silicon carbide (SiC) is being considered as a fuel cladding material for accident tolerant fuel under the Light Water Reactor Sustainability (LWRS) Program sponsored by the Nuclear Energy Division of the Department of Energy. Silicon carbide has many potential advantages over traditional zirconium based cladding systems. These include high melting point, low susceptibility to corrosion, and low degradation of mechanical properties under neutron irradiation. In addition, ceramic matrix composites (CMCs) made from SiC have high mechanical toughness enabling these materials to withstand thermal and mechanical shock loading. However, many of the fundamental mechanical and thermal properties of SiC CMCs depend strongly on the fabrication process. As a result, extrapolating current materials science databases for these materials to nuclear applications is not possible. The “Advanced Measurements” work package under the LWRS fuels pathway is tasked with the development of measurement techniques that can characterize fundamental thermal and mechanical properties of SiC CMCs. An emphasis is being placed on development of characterization tools that can used for examination of fresh as well as irradiated samples. The work discuss in this report can be divided into two broad categories. The first involves the development of laser ultrasonic techniques to measure the elastic and yield properties and the second involves the development of laser-based techniques to measurement thermal transport properties. Emphasis has been placed on understanding the anisotropic and heterogeneous nature of SiC CMCs in regards to thermal and mechanical properties. The material properties characterized within this work package will be used as validation of advanced materials physics models of SiC CMCs developed under the LWRS fuels pathway. In addition, it is envisioned that similar measurement techniques can be used to provide process control and quality assurance as well as measurement of

  14. Select Methodology for Validating Advanced Satellite Measurement Systems

    NASA Technical Reports Server (NTRS)

    Larar, Allen M.; Zhou, Daniel K.; Liu, Xi; Smith, William L.

    2008-01-01

    Advanced satellite sensors are tasked with improving global measurements of the Earth's atmosphere, clouds, and surface to enable enhancements in weather prediction, climate monitoring capability, and environmental change detection. Measurement system validation is crucial to achieving this goal and maximizing research and operational utility of resultant data. Field campaigns including satellite under-flights with well calibrated FTS sensors aboard high-altitude aircraft are an essential part of the validation task. This presentation focuses on an overview of validation methodology developed for assessment of high spectral resolution infrared systems, and includes results of preliminary studies performed to investigate the performance of the Infrared Atmospheric Sounding Interferometer (IASI) instrument aboard the MetOp-A satellite.

  15. Canadian Educational Approaches for the Advancement of Pharmacy Practice

    PubMed Central

    Louizos, Christopher; Austin, Zubin

    2014-01-01

    Canadian faculties (schools) of pharmacy are actively engaged in the advancement and restructuring of their programs in response to the shift in pharmacy to pharmacists having/assuming an advanced practitioner role. Unfortunately, there is a paucity of evidence outlining optimal strategies for accomplishing this task. This review explores several educational changes proposed in the literature to aid in the advancement of pharmacy education such as program admission requirements, critical-thinking assessment and teaching methods, improvement of course content delivery, value of interprofessional education, advancement of practical experiential education, and mentorship strategies. Collectively, implementation of these improvements to pharmacy education will be crucial in determining the direction the profession will take. PMID:25258448

  16. Measuring respiration rates in marine fish larvae: challenges and advances.

    PubMed

    Peck, M A; Moyano, M

    2016-01-01

    Metabolic costs can be extremely high in marine fish larvae and gaining reliable estimates of the effects of intrinsic and extrinsic factors on those costs is important to understand environmental constraints on early growth and survival. This review provides an historical perspective of measurements of larval marine fish respiration (O2 consumption) including the methods (Winkler, manometric, polarographic, paramagnetic and optodes) and systems (closed system to intermittent-flow) used. This study compares and systematically reviews the results (metabolic rates, ontogenetic changes and taxonomic differences) obtained from 59 studies examining 53 species from 30 families. Standard (anaesthetized or darkness), routine and active respiration rates were reported in 14, 94 and 8% of the studies and much more work has been performed on larvae of temperate (88%) compared with tropical (9%) and polar (3%) species. More than 35% of the studies have been published since 2000 owing to both advances in oxygen sensors and the growing emphasis on understanding physiological effects of environmental change. Common protocols are needed to facilitate cross-taxa comparisons such as the effect of temperature (Q10 : 1·47-3·47), body mass (slope of allometric changes in O2 consumption rate from 0·5 to 1·3) and activity level on metabolic costs as measured via respiration rate. A set of recommendations is provided that will make it easier for researchers to design measurement systems, to judge the reliability of measurements and to make inter-comparisons among studies and species.

  17. Report calls for measures to advance climate modeling

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2012-09-01

    While climate modeling has made enormous strides over the past several decades, a critical step toward making more rapid, efficient, and coordinated progress in modeling would require “an evolutionary change in U.S. climate modeling institutions away from developing multiple completely independent models toward a collaborative approach,” according to a 7 September report by a committee of the U.S. National Research Council's Board on Atmospheric Sciences and Climate (BASC). “The Committee believes that the best path forward is a strategy centered around the integration of the decentralized U.S. climate modeling enterprise—across modeling efforts, across a hierarchy of model types, across modeling communities focused on different space and timescales, and between model developers and model output users,” the report notes. “A diversity of approaches is necessary for progress in many areas of climate modeling and is vital for addressing the breadth of users needs.” Entitled A National Strategy for Advancing Climate Modeling, the report states that, “If adopted, this strategy of increased unification amidst diversity will allow the United States to more effectively meet the climate information needs of the Nation in the coming decades and beyond.”

  18. Advanced Active-Magnetic-Bearing Thrust-Measurement System

    NASA Technical Reports Server (NTRS)

    Imlach, Joseph; Kasarda, Mary; Blumber, Eric

    2008-01-01

    An advanced thrust-measurement system utilizes active magnetic bearings to both (1) levitate a floating frame in all six degrees of freedom and (2) measure the levitation forces between the floating frame and a grounded frame. This system was developed for original use in measuring the thrust exerted by a rocket engine mounted on the floating frame, but can just as well be used in other force-measurement applications. This system offers several advantages over prior thrust-measurement systems based on mechanical support by flexures and/or load cells: The system includes multiple active magnetic bearings for each degree of freedom, so that by selective use of one, some, or all of these bearings, it is possible to test a given article over a wide force range in the same fixture, eliminating the need to transfer the article to different test fixtures to obtain the benefit of full-scale accuracy of different force-measurement devices for different force ranges. Like other active magnetic bearings, the active magnetic bearings of this system include closed-loop control subsystems, through which the stiffness and damping characteristics of the magnetic bearings can be modified electronically. The design of the system minimizes or eliminates cross-axis force-measurement errors. The active magnetic bearings are configured to provide support against movement along all three orthogonal Cartesian axes, and such that the support along a given axis does not produce force along any other axis. Moreover, by eliminating the need for such mechanical connections as flexures used in prior thrust-measurement systems, magnetic levitation of the floating frame eliminates what would otherwise be major sources of cross-axis forces and the associated measurement errors. Overall, relative to prior mechanical-support thrust-measurement systems, this system offers greater versatility for adaptation to a variety of test conditions and requirements. The basic idea of most prior active

  19. Probabilistic seismic demand analysis using advanced ground motion intensity measures

    USGS Publications Warehouse

    Tothong, P.; Luco, N.

    2007-01-01

    One of the objectives in performance-based earthquake engineering is to quantify the seismic reliability of a structure at a site. For that purpose, probabilistic seismic demand analysis (PSDA) is used as a tool to estimate the mean annual frequency of exceeding a specified value of a structural demand parameter (e.g. interstorey drift). This paper compares and contrasts the use, in PSDA, of certain advanced scalar versus vector and conventional scalar ground motion intensity measures (IMs). One of the benefits of using a well-chosen IM is that more accurate evaluations of seismic performance are achieved without the need to perform detailed ground motion record selection for the nonlinear dynamic structural analyses involved in PSDA (e.g. record selection with respect to seismic parameters such as earthquake magnitude, source-to-site distance, and ground motion epsilon). For structural demands that are dominated by a first mode of vibration, using inelastic spectral displacement (Sdi) can be advantageous relative to the conventionally used elastic spectral acceleration (Sa) and the vector IM consisting of Sa and epsilon (??). This paper demonstrates that this is true for ordinary and for near-source pulse-like earthquake records. The latter ground motions cannot be adequately characterized by either Sa alone or the vector of Sa and ??. For structural demands with significant higher-mode contributions (under either of the two types of ground motions), even Sdi (alone) is not sufficient, so an advanced scalar IM that additionally incorporates higher modes is used.

  20. SMOS Measurements Preliminary Validation: Objectives and Approach

    NASA Astrophysics Data System (ADS)

    Sabia, Roberto; Gourrion, Jerome; Gabarró, Carolina; Talone, Marco; Portabella, Marcos; Ballabrera, Joaquim; Lopez de Aretxabaleta, Alfredo; Camps, Adriano; Monerris, Alessandra; Font, Jordi

    2010-05-01

    strategy to mitigate the scene-dependent bias found in the SMOS measurements. The comparison of TB departures distributions will be performed within specific classes, aiming at reducing the degrees of freedom of the measurement. Namely, the data will be sorted according to the incidence angle, the wind speed, the across-track distance, the radiometric accuracy and the spatial resolution. Concerning SSS, in turn, the proposed activities will involve inter-comparisons with various external salinity sources. As a further classification, external sources can be distinguished into data coming from models and data collected in-situ. The validation strategy foresees the comparison of SSS misfit (retrieved SSS minus ground-truth SSS) distributions within specific classes. This will be performed sorting geographical areas (different oceans, different zonal frames) and geophysical conditions (e.g. low/high surface temperature, wind speed and SSS conditions). Specific comparisons with in-situ data coming from oceanographic cruises transects and from VOS (Voluntary Observatory Ships) are foreseen, as well as against moored buoys, profilers, and drifters. These data will be arranged in specific match-up datasets, to properly organize the spatio-temporal collocation of the SMOS and in-situ measurements. The possibility of using model solutions for validation will also be considered. Model data are obtained from hindcast simulations from available prediction systems. Concerning the salinity retrieval inversion scheme, efforts will be devoted to the optimization of both the GMF (Geophysical Model Function) and the minimization cost function. With the increase of data availability, the semi-empirical GMF in the ocean salinity Level 2 operational processor will be improved, in particular the roughness-dependent TB term. The introduction of non-linear relationships in the semi-empirical roughness model is a likely extension of this formulation. The prospective approach is to develop, at a

  1. Recent treatment advances and novel therapeutic approaches in epilepsy

    PubMed Central

    Serrano, Enrique

    2015-01-01

    The purpose of this article is to review recent advances in the treatment of epilepsy. It includes five antiepileptic drugs that have been recently added to the pharmacologic armamentarium and surgical techniques that have been developed in the last few years. Finally, we review ongoing research that may have a potential role in future treatments of epilepsy. PMID:26097734

  2. Optogenetic and Chemogenetic Approaches To Advance Monitoring Molecules.

    PubMed

    McElligott, Zoé

    2015-07-15

    Fast-scan cyclic voltammetry (FSCV) is a high-resolution technique used to investigate neurotransmission in vitro, ex vivo, and in vivo. In this Viewpoint, I discuss how optogenetic and chemogenetic methods, when combined with FSCV, can impact and advance our understanding of neurotransmission and enable more detailed investigation of the roles of neurotransmitter systems in normal and disease states.

  3. Advanced quantitative measurement methodology in physics education research

    NASA Astrophysics Data System (ADS)

    Wang, Jing

    The ultimate goal of physics education research (PER) is to develop a theoretical framework to understand and improve the learning process. In this journey of discovery, assessment serves as our headlamp and alpenstock. It sometimes detects signals in student mental structures, and sometimes presents the difference between expert understanding and novice understanding. Quantitative assessment is an important area in PER. Developing research-based effective assessment instruments and making meaningful inferences based on these instruments have always been important goals of the PER community. Quantitative studies are often conducted to provide bases for test development and result interpretation. Statistics are frequently used in quantitative studies. The selection of statistical methods and interpretation of the results obtained by these methods shall be connected to the education background. In this connecting process, the issues of educational models are often raised. Many widely used statistical methods do not make assumptions on the mental structure of subjects, nor do they provide explanations tailored to the educational audience. There are also other methods that consider the mental structure and are tailored to provide strong connections between statistics and education. These methods often involve model assumption and parameter estimation, and are complicated mathematically. The dissertation provides a practical view of some advanced quantitative assessment methods. The common feature of these methods is that they all make educational/psychological model assumptions beyond the minimum mathematical model. The purpose of the study is to provide a comparison between these advanced methods and the pure mathematical methods. The comparison is based on the performance of the two types of methods under physics education settings. In particular, the comparison uses both physics content assessments and scientific ability assessments. The dissertation includes three

  4. Advances in Air-Sea Flux Measurement by Eddy Correlation

    NASA Astrophysics Data System (ADS)

    Blomquist, Byron W.; Huebert, Barry J.; Fairall, Christopher W.; Bariteau, Ludovic; Edson, James B.; Hare, Jeffrey E.; McGillis, Wade R.

    2014-09-01

    Eddy-correlation measurements of the oceanic flux are useful for the development and validation of air-sea gas exchange models and for analysis of the marine carbon cycle. Results from more than a decade of published work and from two recent field programs illustrate the principal interferences from water vapour and motion, demonstrating experimental approaches for improving measurement precision and accuracy. Water vapour cross-sensitivity is the greatest source of error for flux measurements using infrared gas analyzers, often leading to a ten-fold bias in the measured flux. Much of this error is not related to optical contamination, as previously supposed. While various correction schemes have been demonstrated, the use of an air dryer and closed-path analyzer is the most effective way to eliminate this interference. This approach also obviates density corrections described by Webb et al. (Q J R Meteorol 106:85-100, 1980). Signal lag and frequency response are a concern with closed-path systems, but periodic gas pulses at the inlet tip provide for precise determination of lag time and frequency attenuation. Flux attenuation corrections are shown to be 5 % for a cavity ring-down analyzer (CRDS) and dryer with a 60-m inlet line. The estimated flux detection limit for the CRDS analyzer and dryer is a factor of ten better than for IRGAs sampling moist air. While ship-motion interference is apparent with all analyzers tested in this study, decorrelation or regression methods are effective in removing most of this bias from IRGA measurements and may also be applicable to the CRDS.

  5. Impact of Measurement System Characteristics on Advanced Sounder Information Content

    NASA Technical Reports Server (NTRS)

    Larar, Allen M.; Liu, Xu; Zhou, Daniel K.

    2011-01-01

    Advanced satellite sensors are tasked with improving global observations of the Earth's atmosphere, clouds, and surface to enable enhancements in weather prediction, climate monitoring capability, and environmental change detection. Achieving such an improvement in geophysical information inferred from these observations requires optimal usage of data from current systems as well as instrument system enhancements for future sensors. This presentation addresses results of tradeoff studies evaluating the impact of spectral resolution, spectral coverage, instrument noise, and a priori knowledge on remote sensing system information content, with a specific emphasis on thermodynamic state and trace species information obtainable from advanced atmospheric sounders. Particular attention will be devoted toward information achievable from the Atmospheric InfraRed Sounder (AIRS) on the NASA EOS Aqua satellite in orbit since 2002, the Infrared Atmospheric Sounding Interferometer (IASI) aboard MetOp-A since 2006, and the Cross-track Infrared Sounder (CrIS) instrument to fly aboard the NPP and JPSS series of satellites expected to begin in late 2011. While all of these systems cover nearly the same infrared spectral extent, they have very different number of channels, instrument line shapes, coverage continuity, and instrument noise. AIRS is a grating spectrometer having 2378 discrete spectral channels ranging from about 0.4 to 2.2/cm resolution; IASI is a Michelson interferometer with 8461 uniformly-spaced spectral channels of 0.5/cm (apodized) resolution; and CrIS is a Michelson interferometer having 1305 spectral channels of 0.625, 1.250, and 2.50/cm (unapodized) spectral resolution, respectively, over its three continuous but non-overlapping bands. Results of tradeoff studies showing information content sensitivity to assumed measurement system characteristics will be presented.

  6. Measuring Attitudes toward Computers: Two Approaches

    PubMed Central

    Kjerulff, K.H.; Counte, Michael A.

    1984-01-01

    The purpose of this paper is to present two questionnaires developed by the authors to measure attitudes toward computers. The first questionnaire is designed to measure attitudes toward computers in general. The second questionnaire is designed to assess attitudes toward a specific medical information system. Data concerning the reliability of these instruments is presented. Data concerning both the predictive and the concurrent validity of these measures are also presented. The results indicate that scores on both of the questionnaires assessed prior to computer implementation are reliable and valid predictors of post-implementation adaptation to the computer and perceptions of training. Scores on the questionnaires designed to assess specific attitudes, measured at three points in time, are also related to concurrent measures of job satisfaction and adaptation to the computer system.

  7. Advances in the Rising Bubble Technique for discharge measurement

    NASA Astrophysics Data System (ADS)

    Hilgersom, Koen; Luxemburg, Willem; Willemsen, Geert; Bussmann, Luuk

    2014-05-01

    Already in the 19th century, d'Auria described a discharge measurement technique that applies floats to find the depth-integrated velocity (d'Auria, 1882). The basis of this technique was that the horizontal distance that the float travels on its way to the surface is the image of the integrated velocity profile over depth. Viol and Semenov (1964) improved this method by using air bubbles as floats, but still distances were measured manually until Sargent (1981) introduced a technique that could derive the distances from two photographs simultaneously taken from each side of the river bank. Recently, modern image processing techniques proved to further improve the applicability of the method (Hilgersom and Luxemburg, 2012). In the 2012 article, controlling and determining the rising velocity of an air bubble still appeared a major challenge for the application of this method. Ever since, laboratory experiments with different nozzle and tube sizes lead to advances in our self-made equipment enabling us to produce individual air bubbles with a more constant rising velocity. Also, we introduced an underwater camera to on-site determine the rising velocity, which is dependent on the water temperature and contamination, and therefore is site-specific. Camera measurements of the rising velocity proved successful in a laboratory and field setting, although some improvements to the setup are necessary to capture the air bubbles also at depths where little daylight penetrates. References D'Auria, L.: Velocity of streams; A new method to determine correctly the mean velocity of any perpendicular in rivers and canals, (The) American Engineers, 3, 1882. Hilgersom, K.P. and Luxemburg, W.M.J.: Technical Note: How image processing facilitates the rising bubble technique for discharge measurement, Hydrology and Earth System Sciences, 16(2), 345-356, 2012. Sargent, D.: Development of a viable method of stream flow measurement using the integrating float technique, Proceedings of

  8. Modern approaches to blood pressure measurement

    PubMed Central

    Staessen, J.; O'Brien, E.; Thijs, L.; Fagard, R.

    2000-01-01

    BACKGROUND—Blood pressure (BP) is usually measured by conventional sphygmomanometry. Although apparently simple, this procedure is fraught with many potential sources of error. This review focuses on two alternative techniques of BP measurement: ambulatory monitoring and self measurement.
REVIEW—BP values obtained by ambulatory monitoring or self measurement are characterised by high reproducibility, are not subject to digit preference or observer bias, and minimise the transient rise of the blood pressure in response to the surroundings of the clinic or the presence of the observer, the so called white coat effect. For ambulatory monitoring, the upper limits of systolic/diastolic normotension in adults include 130/80 mm Hg for the 24 hour BP and 135/85 and 120/70 mm Hg for the daytime BP and night time BP, respectively. For the the self measured BP these thresholds include 135/85 mm Hg. Automated BP measurement is most useful to identify patients with white coat hypertension. Whether or not white coat hypertension predisposes to sustained hypertension remains debated. However, outcome is better correlated with the ambulatory BP than with the conventional BP. In patients with white coat hypertension, antihypertensive drugs lower the BP in the clinic, but not the ambulatory BP, and also do not improve prognosis. Ambulatory BP monitoring is also better than conventional BP measurement in assessing the effects of treatment. Ambulatory BP monitoring is necessary to diagnose nocturnal hypertension and is especially indicated in patients with borderline hypertension, elderly patients, pregnant women, patients with treatment resistant hypertension, and also in patients with symptoms suggestive of hypotension.
CONCLUSIONS—The newer techniques of BP measurement are now well established in clinical research, for diagnosis in clinical practice, and will increasingly make their appearance in occupational and environmental medicine.


Keywords: ambulatory blood

  9. Advanced optical measuring systems for measuring the properties of fluids and structures

    NASA Technical Reports Server (NTRS)

    Decker, A. J.

    1986-01-01

    Four advanced optical models are reviewed for the measurement of visualization of flow and structural properties. Double-exposure, diffuse-illumination, holographic interferometry can be used for three-dimensional flow visualization. When this method is combined with optical heterodyning, precise measurements of structural displacements or fluid density are possible. Time-average holography is well known as a method for displaying vibrational mode shapes, but it also can be used for flow visualization and flow measurements. Deflectometry is used to measure or visualize the deflection of light rays from collimation. Said deflection occurs because of refraction in a fluid or because of reflection from a tilted surface. The moire technique for deflectometry, when combined with optical heterodyning, permits very precise measurements of these quantities. The rainbow schlieren method of deflectometry allows varying deflection angles to be encoded with colors for visualization.

  10. Personality Measurement in Children: A Dimensional Approach

    ERIC Educational Resources Information Center

    Eysenck, H. J.; And Others

    1970-01-01

    Reported are the results of a personality inventory measuring the personality dimensions of extraversion, neuroticism, psychoticism, and lying, which was administered to over 3,000 school children. (KW)

  11. New Approaches to Aerosol Optical Extinction Measurement

    NASA Astrophysics Data System (ADS)

    Strawa, A. W.; Owano, T.; Moosmuller, H.; Atkinson, D.; Covert, D.; Ahlquist, N.; Schmid, B.

    2002-12-01

    Aerosols can have important influences on climate and the radiation balance of the atmosphere. However, the temporal and spatial variability of aerosols and our inadequate knowledge of aerosol optical properties have lead to large uncertainties in these effects. Thus improved in-situ measurements of aerosol optical properties, in particular measurement of their extinction coefficients, are required. Recently, the relatively new technique of cavity ring-down spectroscopy has been applied to the problem of making fast, accurate measurements of aerosol extinction coefficient. Typically, extinction measurements have been made by measuring the decrease in the intensity of a light beam that has passed through a particulate-laden cell. Often, the cell contains mirrors which reflect the beam several times increasing the optical path length thereby increasing the extinction. Path lengths of up to 400 m have been obtained, which is still insufficient to measure atmospheric extinction in the visible down to background values. In cavity ring-down, a light beam is reflected many thousands of times between two highly reflective mirrors, resulting in a path length of kilometers. The light exiting the cell decreases exponentially with time, and this exponential decay is related to the extinction of the aerosol inside the cell. The CRD instruments can routinely measure sub-Rayleigh equivalent extinction levels of a few Mm-^1 and are generally more rugged and portable than traditional extinction cells. Possible applications of CRD-based extinction cells include studies of visibility, climate forcing by aerosol, and the validation of aerosol retrieval schemes from satellites such as MODIS, MISR, and CALYPSO. This paper will present the motivation for making improved aerosol extinction measurements and discuss the problems in making the measurement. The cavity ring-down technique will be described. In June, 2002, a calibration and methods intercomparison, the Reno Aerosol Optics Study

  12. SUMMARY REPORT ON RESEARCH RESULTS FROM THE ADVANCE MEASUREMENT INITIATIVE (AMI)

    EPA Science Inventory

    EPA created the Advanced Measurement Initiative (AMI) to permit the early and inexpensive evaluation of innovative advanced technology and to encourage broad and rapid application in EPA operations. The AMI program focused on improving EPA's technological capabilities and acceler...

  13. Advanced materials characterization based on full field deformation measurements

    NASA Astrophysics Data System (ADS)

    Carpentier, A. Paige

    Accurate stress-strain constitutive properties are essential for understanding the complex deformation and failure mechanisms for materials with highly anisotropic mechanical properties. Among such materials, glass-fiber- and carbon-fiber-reinforced polymer--matrix composites play a critical role in advanced structural designs. The large number of different methods and specimen types currently required to generate three-dimensional allowables for structural design slows down the material characterization. Also, some of the material constitutive properties are never measured due to the prohibitive cost of the specimens needed. This work shows that simple short-beam shear (SBS) specimens are well-suited for measurement of multiple constitutive properties for composite materials and that can enable a major shift toward accurate material characterization. The material characterization is based on the digital image correlation (DIC) full-field deformation measurement. The full-field-deformation measurement enables additional flexibility for assessment of stress--strain relations, compared to the conventional strain gages. Complex strain distributions, including strong gradients, can be captured. Such flexibility enables simpler test-specimen design and reduces the number of different specimen types required for assessment of stress--strain constitutive behavior. Two key elements show advantage of using DIC in the SBS tests. First, tensile, compressive, and shear stress--strain relations are measured in a single experiment. Second, a counter-intuitive feasibility of closed-form stress and modulus models, normally applicable to long beams, is demonstrated for short-beam specimens. The modulus and stress--strain data are presented for glass/epoxy and carbon/epoxy material systems. The applicability of the developed method to static, fatigue, and impact load rates is also demonstrated. In a practical method to determine stress-strain constitutive relations, the stress

  14. Advanced Techniques for Power System Identification from Measured Data

    SciTech Connect

    Pierre, John W.; Wies, Richard; Trudnowski, Daniel

    2008-11-25

    Time-synchronized measurements provide rich information for estimating a power-system's electromechanical modal properties via advanced signal processing. This information is becoming critical for the improved operational reliability of interconnected grids. A given mode's properties are described by its frequency, damping, and shape. Modal frequencies and damping are useful indicators of power-system stress, usually declining with increased load or reduced grid capacity. Mode shape provides critical information for operational control actions. This project investigated many advanced techniques for power system identification from measured data focusing on mode frequency and damping ratio estimation. Investigators from the three universities coordinated their effort with Pacific Northwest National Laboratory (PNNL). Significant progress was made on developing appropriate techniques for system identification with confidence intervals and testing those techniques on field measured data and through simulation. Experimental data from the western area power system was provided by PNNL and Bonneville Power Administration (BPA) for both ambient conditions and for signal injection tests. Three large-scale tests were conducted for the western area in 2005 and 2006. Measured field PMU (Phasor Measurement Unit) data was provided to the three universities. A 19-machine simulation model was enhanced for testing the system identification algorithms. Extensive simulations were run with this model to test the performance of the algorithms. University of Wyoming researchers participated in four primary activities: (1) Block and adaptive processing techniques for mode estimation from ambient signals and probing signals, (2) confidence interval estimation, (3) probing signal design and injection method analysis, and (4) performance assessment and validation from simulated and field measured data. Subspace based methods have been use to improve previous results from block processing

  15. Advancing nursing leadership: a model for program implementation and measurement.

    PubMed

    Omoike, Osei; Stratton, Karen M; Brooks, Beth A; Ohlson, Susan; Storfjell, Judy Lloyd

    2011-01-01

    Despite the abundant literature documenting the need for nurse management education and career development, only recently have professional standards been targeted for this group. Competency standards for nurse leaders repeatedly identify systems-level concepts including finance and budget, communication skills, strategic management, human resources management, change management, and computer technology skills. However, educational initiatives to meet these standards are still at the early stages and most nurse leaders continue to acquire knowledge and experience through "on-the-job" training. This article will illustrate the need for partnerships and collaboration between academia and hospitals to advance nursing leadership to the next century. In addition, a tool to measure the impact of a graduate certificate program in nursing administration on nurse leader competencies is presented. Overall, the certificate program has been successful in multiple ways; it has "graduated" almost 80 nurse leaders, improved participant competence in their role at the systems level, as well as providing an impetus for completion of a graduate degree post program. PMID:21900817

  16. ADVANCING THE FUNDAMENTAL UNDERSTANDING AND SCALE-UP OF TRISO FUEL COATERS VIA ADVANCED MEASUREMENT AND COMPUTATIONAL TECHNIQUES

    SciTech Connect

    Biswas, Pratim; Al-Dahhan, Muthanna

    2012-11-01

    Tri-isotropic (TRISO) fuel particle coating is critical for the future use of nuclear energy produced byadvanced gas reactors (AGRs). The fuel kernels are coated using chemical vapor deposition in a spouted fluidized bed. The challenges encountered in operating TRISO fuel coaters are due to the fact that in modern AGRs, such as High Temperature Gas Reactors (HTGRs), the acceptable level of defective/failed coated particles is essentially zero. This specification requires processes that produce coated spherical particles with even coatings having extremely low defect fractions. Unfortunately, the scale-up and design of the current processes and coaters have been based on empirical approaches and are operated as black boxes. Hence, a voluminous amount of experimental development and trial and error work has been conducted. It has been clearly demonstrated that the quality of the coating applied to the fuel kernels is impacted by the hydrodynamics, solids flow field, and flow regime characteristics of the spouted bed coaters, which themselves are influenced by design parameters and operating variables. Further complicating the outlook for future fuel-coating technology and nuclear energy production is the fact that a variety of new concepts will involve fuel kernels of different sizes and with compositions of different densities. Therefore, without a fundamental understanding the underlying phenomena of the spouted bed TRISO coater, a significant amount of effort is required for production of each type of particle with a significant risk of not meeting the specifications. This difficulty will significantly and negatively impact the applications of AGRs for power generation and cause further challenges to them as an alternative source of commercial energy production. Accordingly, the proposed work seeks to overcome such hurdles and advance the scale-up, design, and performance of TRISO fuel particle spouted bed coaters. The overall objectives of the proposed work are

  17. Measuring political commitment and opportunities to advance food and nutrition security: piloting a rapid assessment tool.

    PubMed

    Fox, Ashley M; Balarajan, Yarlini; Cheng, Chloe; Reich, Michael R

    2015-06-01

    Lack of political commitment has been identified as a primary reason for the low priority that food and nutrition interventions receive from national governments relative to the high disease burden caused by malnutrition. Researchers have identified a number of factors that contribute to food and nutrition's 'low-priority cycle' on national policy agendas, but few tools exist to rapidly measure political commitment and identify opportunities to advance food and nutrition on the policy agenda. This article presents a theory-based rapid assessment approach to gauging countries' level of political commitment to food and nutrition security and identifying opportunities to advance food and nutrition on the policy agenda. The rapid assessment tool was piloted among food and nutrition policymakers and planners in 10 low- and middle-income countries in April to June 2013. Food and nutrition commitment and policy opportunity scores were calculated for each country and strategies to advance food and nutrition on policy agendas were designed for each country. The article finds that, in a majority of countries, political leaders had verbally and symbolically committed to addressing food and nutrition, but adequate financial resources were not allocated to implement specific programmes. In addition, whereas the low cohesion of the policy community has been viewed a major underlying cause of the low-priority status of food and nutrition, the analysis finds that policy community cohesion and having a well thought-out policy alternative were present in most countries. This tool may be useful to policymakers and planners providing information that can be used to benchmark and/or evaluate advocacy efforts to advance reforms in the food and nutrition sector; furthermore, the results can help identify specific strategies that can be employed to move the food and nutrition agenda forward. This tool complements others that have been recently developed to measure national commitment to

  18. Measuring political commitment and opportunities to advance food and nutrition security: piloting a rapid assessment tool.

    PubMed

    Fox, Ashley M; Balarajan, Yarlini; Cheng, Chloe; Reich, Michael R

    2015-06-01

    Lack of political commitment has been identified as a primary reason for the low priority that food and nutrition interventions receive from national governments relative to the high disease burden caused by malnutrition. Researchers have identified a number of factors that contribute to food and nutrition's 'low-priority cycle' on national policy agendas, but few tools exist to rapidly measure political commitment and identify opportunities to advance food and nutrition on the policy agenda. This article presents a theory-based rapid assessment approach to gauging countries' level of political commitment to food and nutrition security and identifying opportunities to advance food and nutrition on the policy agenda. The rapid assessment tool was piloted among food and nutrition policymakers and planners in 10 low- and middle-income countries in April to June 2013. Food and nutrition commitment and policy opportunity scores were calculated for each country and strategies to advance food and nutrition on policy agendas were designed for each country. The article finds that, in a majority of countries, political leaders had verbally and symbolically committed to addressing food and nutrition, but adequate financial resources were not allocated to implement specific programmes. In addition, whereas the low cohesion of the policy community has been viewed a major underlying cause of the low-priority status of food and nutrition, the analysis finds that policy community cohesion and having a well thought-out policy alternative were present in most countries. This tool may be useful to policymakers and planners providing information that can be used to benchmark and/or evaluate advocacy efforts to advance reforms in the food and nutrition sector; furthermore, the results can help identify specific strategies that can be employed to move the food and nutrition agenda forward. This tool complements others that have been recently developed to measure national commitment to

  19. Advanced Numerical Methods and Software Approaches for Semiconductor Device Simulation

    DOE PAGES

    Carey, Graham F.; Pardhanani, A. L.; Bova, S. W.

    2000-01-01

    In this article we concisely present several modern strategies that are applicable to driftdominated carrier transport in higher-order deterministic models such as the driftdiffusion, hydrodynamic, and quantum hydrodynamic systems. The approaches include extensions of “upwind” and artificial dissipation schemes, generalization of the traditional Scharfetter – Gummel approach, Petrov – Galerkin and streamline-upwind Petrov Galerkin (SUPG), “entropy” variables, transformations, least-squares mixed methods and other stabilized Galerkin schemes such as Galerkin least squares and discontinuous Galerkin schemes. The treatment is representative rather than an exhaustive review and several schemes are mentioned only briefly with appropriate reference to the literature. Some of themore » methods have been applied to the semiconductor device problem while others are still in the early stages of development for this class of applications. We have included numerical examples from our recent research tests with some of the methods. A second aspect of the work deals with algorithms that employ unstructured grids in conjunction with adaptive refinement strategies. The full benefits of such approaches have not yet been developed in this application area and we emphasize the need for further work on analysis, data structures and software to support adaptivity. Finally, we briefly consider some aspects of software frameworks. These include dial-an-operator approaches such as that used in the industrial simulator PROPHET, and object-oriented software support such as those in the SANDIA National Laboratory framework SIERRA.« less

  20. Advanced numerical methods and software approaches for semiconductor device simulation

    SciTech Connect

    CAREY,GRAHAM F.; PARDHANANI,A.L.; BOVA,STEVEN W.

    2000-03-23

    In this article the authors concisely present several modern strategies that are applicable to drift-dominated carrier transport in higher-order deterministic models such as the drift-diffusion, hydrodynamic, and quantum hydrodynamic systems. The approaches include extensions of upwind and artificial dissipation schemes, generalization of the traditional Scharfetter-Gummel approach, Petrov-Galerkin and streamline-upwind Petrov Galerkin (SUPG), entropy variables, transformations, least-squares mixed methods and other stabilized Galerkin schemes such as Galerkin least squares and discontinuous Galerkin schemes. The treatment is representative rather than an exhaustive review and several schemes are mentioned only briefly with appropriate reference to the literature. Some of the methods have been applied to the semiconductor device problem while others are still in the early stages of development for this class of applications. They have included numerical examples from the recent research tests with some of the methods. A second aspect of the work deals with algorithms that employ unstructured grids in conjunction with adaptive refinement strategies. The full benefits of such approaches have not yet been developed in this application area and they emphasize the need for further work on analysis, data structures and software to support adaptivity. Finally, they briefly consider some aspects of software frameworks. These include dial-an-operator approaches such as that used in the industrial simulator PROPHET, and object-oriented software support such as those in the SANDIA National Laboratory framework SIERRA.

  1. A Greener Approach for Measuring Colligative Properties

    ERIC Educational Resources Information Center

    McCarthy, Sean M.; Gordon-Wylie, Scott W.

    2005-01-01

    As a first step towards the greening of instructional laboratories, we present a new greener version of a laboratory procedure designed to measure colligative properties. The greener procedure substitutes the nontoxic, noncarcinogenic compounds stearic, myristic, lauric, and palmitic acids for the less benign aromatic compounds p-dichlorobenzene,…

  2. Measuring Fear of Death: A Multidimensional Approach.

    ERIC Educational Resources Information Center

    Littlefield, Christine; Fleming, Stephen

    1985-01-01

    Examined fear of death in 87 students who viewed films designed to manipulate anxiety. Results showed high scores on the Templer fear of death scale correlated with longer response latencies to death than neutral words on the word association test, indicating a positive association between direct and indirect measures. (JAC)

  3. Recent advances in bioprinting techniques: approaches, applications and future prospects.

    PubMed

    Li, Jipeng; Chen, Mingjiao; Fan, Xianqun; Zhou, Huifang

    2016-01-01

    Bioprinting technology shows potential in tissue engineering for the fabrication of scaffolds, cells, tissues and organs reproducibly and with high accuracy. Bioprinting technologies are mainly divided into three categories, inkjet-based bioprinting, pressure-assisted bioprinting and laser-assisted bioprinting, based on their underlying printing principles. These various printing technologies have their advantages and limitations. Bioprinting utilizes biomaterials, cells or cell factors as a "bioink" to fabricate prospective tissue structures. Biomaterial parameters such as biocompatibility, cell viability and the cellular microenvironment strongly influence the printed product. Various printing technologies have been investigated, and great progress has been made in printing various types of tissue, including vasculature, heart, bone, cartilage, skin and liver. This review introduces basic principles and key aspects of some frequently used printing technologies. We focus on recent advances in three-dimensional printing applications, current challenges and future directions. PMID:27645770

  4. Laser Sounder Approach for Measuring Atmospheric CO2 from Orbit

    NASA Technical Reports Server (NTRS)

    Krainak, Michael A.; Andrews, Arlyn E.; Allan, Graham R.; Burris, John F.; Collatz, G. James; Riris, Harris; Stephen, Mark A.; Sun, Xiao-Li; Abshire, James B.

    2004-01-01

    We report on an active remote sensing approach using an erbium fiber amplifier based transmitter for atmospheric CO2 measurements in an overtone band near 1.57 microns and initial horizontal path measurements to less than 1% precision.

  5. Advances in Fast Response Acoustically Derived Air Temperature Measurements

    NASA Astrophysics Data System (ADS)

    Bogoev, Ivan; Jacobsen, Larry; Horst, Thomas; Conrad, Benjamin

    2016-04-01

    Fast-response accurate air-temperature measurements are required when estimating turbulent fluxes of heat, water and carbon dioxide by open-path eddy-covariance technique. In comparison with contact thermometers like thermocouples, ultra-sonic thermometers do not suffer from solar radiation loading, water vapor condensation and evaporative cooling effects. Consequently they have the potential to provide more accurate true air temperature measurements. The absolute accuracy of the ultrasonic thermometer is limited by the following parameters: the distance between the transducer pairs, transducer delays associated with the electrical-acoustic signal conversion that vary with temperature, components of the wind vector that are normal to the ultrasonic paths, and humidity. The distance between the transducer pairs is commonly obtained by coordinate measuring machine. Improved accuracy demonstrated in this study results from increased stiffness in the anemometer head to better maintain the ultrasonic path-length distances. To further improve accuracy and account for changes in transducer delays and distance as a function of temperature, these parameters are characterized in a zero-wind chamber over the entire operating temperature range. When the sonic anemometer is combined with a co-located fast-response water vapor analyzer, like in the IRGASON instrument, speed of sound can be compensated for humidity effects on a point-by-point basis resulting in a true fast-response air temperature measurement. Laboratory test results show that when the above steps are implemented in the calibration of the ultrasonic thermometer air-temperature accuracy better than ±0.5 degrees Celsius can be achieved over the entire operating range. The approach is also validated in a field inter-comparison with an aspirated thermistor probe mounted in a radiation shield.

  6. A Computationally Based Approach to Homogenizing Advanced Alloys

    SciTech Connect

    Jablonski, P D; Cowen, C J

    2011-02-27

    We have developed a computationally based approach to optimizing the homogenization heat treatment of complex alloys. The Scheil module within the Thermo-Calc software is used to predict the as-cast segregation present within alloys, and DICTRA (Diffusion Controlled TRAnsformations) is used to model the homogenization kinetics as a function of time, temperature and microstructural scale. We will discuss this approach as it is applied to both Ni based superalloys as well as the more complex (computationally) case of alloys that solidify with more than one matrix phase as a result of segregation. Such is the case typically observed in martensitic steels. With these alloys it is doubly important to homogenize them correctly, especially at the laboratory scale, since they are austenitic at high temperature and thus constituent elements will diffuse slowly. The computationally designed heat treatment and the subsequent verification real castings are presented.

  7. The Person Approach: Concepts, Measurement Models, and Research Strategy

    ERIC Educational Resources Information Center

    Magnusson, David

    2003-01-01

    This chapter discusses the "person approach" to studying developmental processes by focusing on the distinction and complementarity between this holistic-interactionistic framework and what has become designated as the variable approach. Particular attention is given to measurement models for use in the person approach. The discussion on the…

  8. Advances in Non-contact Measurement of Creep Properties

    NASA Technical Reports Server (NTRS)

    Hyers, Robert W.; Canepari, Stacy; Rogers, Jan. R.

    2009-01-01

    Our team has developed a novel approach to measuring creep at extremely high temperatures using electrostatic levitation (ESL). This method has been demonstrated on niobium up to 2300 C, while ESL has melted tungsten (3400 C). High-precision machined spheres of the sample are levitated in the NASA MSFC ESL, a national user facility, and heated with a laser. The laser is aligned off-center so that the absorbed photons transfer their momentum to the sample, causing it to rotate at up to 250,000+ RPM. The rapid rotation loads the sample through centripetal acceleration, causing it to deform. The deformation of the sample is captured on high-speed video, which is analyzed by machine-vision software from the University of Massachusetts. The deformations are compared to finite element models to determine the constitutive constants in the creep relation. Furthermore, the noncontact method exploits stress gradients within the sample to determine the stress exponent in a single test. This method was validated in collaboration with the University of Tennessee for niobium at 1985 C, with agreement within the uncertainty of the conventional measurements. A similar method is being employed on Ultra-High-Temperature ZrB2- SiC composites, which may see application in rocket nozzles and sharp leading edges for hypersonic vehicles.

  9. State of Modern Measurement Approaches in Social Work Research Literature

    ERIC Educational Resources Information Center

    Unick, George J.; Stone, Susan

    2010-01-01

    The need to develop measures that tap into constructs of interest to social work, refine existing measures, and ensure that measures function adequately across diverse populations of interest is critical. Item response theory (IRT) is a modern measurement approach that is increasingly seen as an essential tool in a number of allied professions.…

  10. Innovative United Kingdom Approaches To Measuring Service Quality.

    ERIC Educational Resources Information Center

    Winkworth, Ian

    2001-01-01

    Reports on approaches to measuring the service quality of academic libraries in the United Kingdom. Discusses the role of government and the national background of quality measurement; measurement frameworks; better use of statistics; benchmarking; measuring user satisfaction; and possible future development. (Author/LRW)

  11. Advanced Modular Power Approach to Affordable, Supportable Space Systems

    NASA Technical Reports Server (NTRS)

    Oeftering, Richard C.; Kimnach, Greg L.; Fincannon, James; Mckissock,, Barbara I.; Loyselle, Patricia L.; Wong, Edmond

    2013-01-01

    Recent studies of missions to the Moon, Mars and Near Earth Asteroids (NEA) indicate that these missions often involve several distinct separately launched vehicles that must ultimately be integrated together in-flight and operate as one unit. Therefore, it is important to see these vehicles as elements of a larger segmented spacecraft rather than separate spacecraft flying in formation. The evolution of large multi-vehicle exploration architecture creates the need (and opportunity) to establish a global power architecture that is common across all vehicles. The Advanced Exploration Systems (AES) Modular Power System (AMPS) project managed by NASA Glenn Research Center (GRC) is aimed at establishing the modular power system architecture that will enable power systems to be built from a common set of modular building blocks. The project is developing, demonstrating and evaluating key modular power technologies that are expected to minimize non-recurring development costs, reduce recurring integration costs, as well as, mission operational and support costs. Further, modular power is expected to enhance mission flexibility, vehicle reliability, scalability and overall mission supportability. The AMPS project not only supports multi-vehicle architectures but should enable multi-mission capability as well. The AMPS technology development involves near term demonstrations involving developmental prototype vehicles and field demonstrations. These operational demonstrations not only serve as a means of evaluating modular technology but also provide feedback to developers that assure that they progress toward truly flexible and operationally supportable modular power architecture.

  12. Advances in a distributed approach for ocean model data interoperability

    USGS Publications Warehouse

    Signell, Richard P.; Snowden, Derrick P.

    2014-01-01

    An infrastructure for earth science data is emerging across the globe based on common data models and web services. As we evolve from custom file formats and web sites to standards-based web services and tools, data is becoming easier to distribute, find and retrieve, leaving more time for science. We describe recent advances that make it easier for ocean model providers to share their data, and for users to search, access, analyze and visualize ocean data using MATLAB® and Python®. These include a technique for modelers to create aggregated, Climate and Forecast (CF) metadata convention datasets from collections of non-standard Network Common Data Form (NetCDF) output files, the capability to remotely access data from CF-1.6-compliant NetCDF files using the Open Geospatial Consortium (OGC) Sensor Observation Service (SOS), a metadata standard for unstructured grid model output (UGRID), and tools that utilize both CF and UGRID standards to allow interoperable data search, browse and access. We use examples from the U.S. Integrated Ocean Observing System (IOOS®) Coastal and Ocean Modeling Testbed, a project in which modelers using both structured and unstructured grid model output needed to share their results, to compare their results with other models, and to compare models with observed data. The same techniques used here for ocean modeling output can be applied to atmospheric and climate model output, remote sensing data, digital terrain and bathymetric data.

  13. Advancing Partnerships Towards an Integrated Approach to Oil Spill Response

    NASA Astrophysics Data System (ADS)

    Green, D. S.; Stough, T.; Gallegos, S. C.; Leifer, I.; Murray, J. J.; Streett, D.

    2015-12-01

    Oil spills can cause enormous ecological and economic devastation, necessitating application of the best science and technology available, and remote sensing is playing a growing critical role in the detection and monitoring of oil spills, as well as facilitating validation of remote sensing oil spill products. The FOSTERRS (Federal Oil Science Team for Emergency Response Remote Sensing) interagency working group seeks to ensure that during an oil spill, remote sensing assets (satellite/aircraft/instruments) and analysis techniques are quickly, effectively, appropriately, and seamlessly available to oil spills responders. Yet significant challenges remain for addressing oils spanning a vast range of chemical properties that may be spilled from the Tropics to the Arctic, with algorithms and scientific understanding needing advances to keep up with technology. Thus, FOSTERRS promotes enabling scientific discovery to ensure robust utilization of available technology as well as identifying technologies moving up the TRL (Technology Readiness Level). A recent FOSTERRS facilitated support activity involved deployment of the AVIRIS NG (Airborne Visual Infrared Imaging Spectrometer- Next Generation) during the Santa Barbara Oil Spill to validate the potential of airborne hyperspectral imaging to real-time map beach tar coverage including surface validation data. Many developing airborne technologies have potential to transition to space-based platforms providing global readiness.

  14. Visualizing approaches for displaying measures of sentiment

    NASA Astrophysics Data System (ADS)

    Kase, Sue E.; Roy, Heather; Cassenti, Daniel N.

    2015-05-01

    The overall purpose of intelligence analysis platforms is to extract key information from multi-source data. Ultimately, these systems are meant to save intelligence analysts time and effort by offering knowledge discovery capabilities. However, intelligence analysis platforms only assist analysts to the extent they are designed with human factors in mind. Poorly designed intelligence analysis platforms can hinder the knowledge discovery process, or worse, promote the misinterpretation of analysis results. Future intelligence systems must be critical enablers for improving speed, efficiency, and effectiveness of command-level decision making. Human-centered research is needed to address the challenge of visualizing large data collections to facilitate orientation and context, enable the discovery and selection of relevant information, and provide dynamic feedback for identifying changes in the state of a targeted region or topic. From the perspective of the `Human as a Data Explorer,' this study investigates the visual presentation of intelligence information to support timely and accurate decision making. The investigation is a starting point in understanding the rich and varied set of information visualizations sponsored by the Army in recent years. A human-subjects experiment explores two visualization approaches against a control condition for displaying sentiment about a set of topics with an emphasis on the performance metrics of decision accuracy and response time. The resulting data analysis is the first in a series of experiments providing input for technology development informing future interface designs and system prototypes.

  15. A review of hemorheology: Measuring techniques and recent advances

    NASA Astrophysics Data System (ADS)

    Sousa, Patrícia C.; Pinho, Fernando T.; Alves, Manuel A.; Oliveira, Mónica S. N.

    2016-02-01

    Significant progress has been made over the years on the topic of hemorheology, not only in terms of the development of more accurate and sophisticated techniques, but also in terms of understanding the phenomena associated with blood components, their interactions and impact upon blood properties. The rheological properties of blood are strongly dependent on the interactions and mechanical properties of red blood cells, and a variation of these properties can bring further insight into the human health state and can be an important parameter in clinical diagnosis. In this article, we provide both a reference for hemorheological research and a resource regarding the fundamental concepts in hemorheology. This review is aimed at those starting in the field of hemodynamics, where blood rheology plays a significant role, but also at those in search of the most up-to-date findings (both qualitative and quantitative) in hemorheological measurements and novel techniques used in this context, including technical advances under more extreme conditions such as in large amplitude oscillatory shear flow or under extensional flow, which impose large deformations comparable to those found in the microcirculatory system and in diseased vessels. Given the impressive rate of increase in the available knowledge on blood flow, this review is also intended to identify areas where current knowledge is still incomplete, and which have the potential for new, exciting and useful research. We also discuss the most important parameters that can lead to an alteration of blood rheology, and which as a consequence can have a significant impact on the normal physiological behavior of blood.

  16. Advances in Assays and Analytical Approaches for Botulinum Toxin Detection

    SciTech Connect

    Grate, Jay W.; Ozanich, Richard M.; Warner, Marvin G.; Bruckner-Lea, Cindy J.; Marks, James D.

    2010-08-04

    Methods to detect botulinum toxin, the most poisonous substance known, are reviewed. Current assays are being developed with two main objectives in mind: 1) to obtain sufficiently low detection limits to replace the mouse bioassay with an in vitro assay, and 2) to develop rapid assays for screening purposes that are as sensitive as possible while requiring an hour or less to process the sample an obtain the result. This review emphasizes the diverse analytical approaches and devices that have been developed over the last decade, while also briefly reviewing representative older immunoassays to provide background and context.

  17. Gasificaton Transport: A Multiphase CFD Approach & Measurements

    SciTech Connect

    Dimitri Gidaspow; Veeraya Jiradilok; Mayank Kashyap; Benjapon Chalermsinsuwan

    2009-02-14

    The objective of this project was to develop predictive theories for the dispersion and mass transfer coefficients and to measure them in the turbulent fluidization regime, using existing facilities. A second objective was to use our multiphase CFD tools to suggest optimized gasifier designs consistent with aims of Future Gen. We have shown that the kinetic theory based CFD codes correctly compute: (1) Dispersion coefficients; and (2) Mass transfer coefficients. Hence, the kinetic theory based CFD codes can be used for fluidized bed reactor design without any such inputs. We have also suggested a new energy efficient method of gasifying coal and producing electricity using a molten carbonate fuel cell. The principal product of this new scheme is carbon dioxide which can be converted into useful products such as marble, as is done very slowly in nature. We believe this scheme is a lot better than the canceled FutureGen, since the carbon dioxide is safely sequestered.

  18. Measuring up: Advances in How We Assess Reading Ability

    ERIC Educational Resources Information Center

    Sabatini, John; Albro, Elizabeth; O'Reilly, Tenaha

    2012-01-01

    In recent decades, the science of reading acquisition, processes, and individual differences in general and special populations has been continuously advancing through interdisciplinary research in cognitive, psycholinguistic, developmental, genetic, neuroscience, cross-language studies, and experimental comparison studies of effective…

  19. Advancing health literacy measurement: a pathway to better health and health system performance.

    PubMed

    Pleasant, Andrew

    2014-12-01

    The concept of health literacy initially emerged and continues to gain strength as an approach to improving health status and the performance of health systems. Numerous studies clearly link low levels of education, literacy, and health literacy with poor health, poor health care utilization, increased barriers to care, and early death. However, theoretical understandings and methods of measuring the complex social construct of health literacy have experienced a continual evolution that remains incomplete. As a result, the seemingly most-cited definition of health literacy proposed in the now-decade-old Institute of Medicine report on health literacy is long overdue for updating. Such an effort should engage a broad and diverse set of health literacy researchers, practitioners, and members of the public in creating a definition that can earn broad consensus through validation testing in a rigorous scientific approach. That effort also could produce the basis for a new universally applicable measure of health literacy. Funders, health systems, and policymakers should reconsider their timid approach to health literacy. Although the field and corresponding evidence base are not perfect, health literacy-especially when combined with a focus on prevention and integrative health-is one of the most promising approaches to advancing public health. PMID:25491583

  20. Advancing Health Literacy Measurement: A Pathway to Better Health and Health System Performance

    PubMed Central

    Pleasant, Andrew

    2014-01-01

    The concept of health literacy initially emerged and continues to gain strength as an approach to improving health status and the performance of health systems. Numerous studies clearly link low levels of education, literacy, and health literacy with poor health, poor health care utilization, increased barriers to care, and early death. However, theoretical understandings and methods of measuring the complex social construct of health literacy have experienced a continual evolution that remains incomplete. As a result, the seemingly most-cited definition of health literacy proposed in the now-decade-old Institute of Medicine report on health literacy is long overdue for updating. Such an effort should engage a broad and diverse set of health literacy researchers, practitioners, and members of the public in creating a definition that can earn broad consensus through validation testing in a rigorous scientific approach. That effort also could produce the basis for a new universally applicable measure of health literacy. Funders, health systems, and policymakers should reconsider their timid approach to health literacy. Although the field and corresponding evidence base are not perfect, health literacy—especially when combined with a focus on prevention and integrative health—is one of the most promising approaches to advancing public health. PMID:25491583

  1. Assessing macroinvertebrate biodiversity in freshwater ecosystems: Advances and challenges in dna-based approaches

    USGS Publications Warehouse

    Pfrender, M.E.; Ferrington, L.C.; Hawkins, C.P.; Hartzell, P.L.; Bagley, M.; Jackson, S.; Courtney, G.W.; Larsen, D.P.; Creutzburg, B.R.; Levesque, C.A.; Epler, J.H.; Morse, J.C.; Fend, S.; Petersen, M.J.; Ruiter, D.; Schindel, D.; Whiting, M.

    2010-01-01

    Assessing the biodiversity of macroinvertebrate fauna in freshwater ecosystems is an essential component of both basic ecological inquiry and applied ecological assessments. Aspects of taxonomic diversity and composition in freshwater communities are widely used to quantify water quality and measure the efficacy of remediation and restoration efforts. The accuracy and precision of biodiversity assessments based on standard morphological identifications are often limited by taxonomic resolution and sample size. Morphologically based identifications are laborious and costly, significantly constraining the sample sizes that can be processed. We suggest that the development of an assay platform based on DNA signatures will increase the precision and ease of quantifying biodiversity in freshwater ecosystems. Advances in this area will be particularly relevant for benthic and planktonic invertebrates, which are often monitored by regulatory agencies. Adopting a genetic assessment platform will alleviate some of the current limitations to biodiversity assessment strategies. We discuss the benefits and challenges associated with DNA-based assessments and the methods that are currently available. As recent advances in microarray and next-generation sequencing technologies will facilitate a transition to DNA-based assessment approaches, future research efforts should focus on methods for data collection, assay platform development, establishing linkages between DNA signatures and well-resolved taxonomies, and bioinformatics. ?? 2010 by The University of Chicago Press.

  2. The Geometric Approach for Constructing Sinai-Ruelle-Bowen Measures

    NASA Astrophysics Data System (ADS)

    Climenhaga, Vaughn; Luzzatto, Stefano; Pesin, Yakov

    2016-09-01

    An important class of `physically relevant' measures for dynamical systems with hyperbolic behavior is given by Sinai-Ruelle-Bowen (SRB) measures. We survey various techniques for constructing SRB measures and studying their properties, paying special attention to the geometric `push-forward' approach. After describing this approach in the uniformly hyperbolic setting, we review recent work that extends it to non-uniformly hyperbolic systems.

  3. Recent Advances in Treatment Approaches of Mucopolysaccharidosis VI.

    PubMed

    Giugliani, Roberto; Carvalho, Clarissa Gutiérrez; Herber, Silvani; de Camargo Pinto, Louise Lapagesse

    2011-06-01

    Mucopolysaccharidosis VI is caused by accumulation of the glycosaminoglycan dermatan sulfate in all tissues due to decreased activity of the enzyme arylsulfatase B. Patients exhibit multisystemic signs and symptoms in a chronic and progressive manner, especially with changes in the skeleton, cardiopulmonary system, cornea, skin, liver, spleen and meninges. Patients usually have normal intelligence. In the past, treatment of mucopolysaccharidoses was limited to palliative medical care. The outcome for affected patients improved with the introduction of new technologies as hematopoietic stem cell transplantation, relegated to specific situations after enzyme replacement therapy (ERT) became available. The specific ERT for MPS VI, galsulfase (Naglazyme®, Biomarin Pharmaceutical) was approved in 2005 by FDA and in 2006 by EMEA, and three clinical studies including 56 patients have evaluated the efficacy and safety. Long-term follow up data with patients treated up to 5 years showed that ERT is well tolerated and associated with sustained improvements in the patients' clinical condition. Intrathecal ERT may be considered in situations of high neurosurgical risk but still it is experimental in humans, as is intra-articular ERT. It is possible that the full impact of this therapy will only be demonstrated when patients are identified and treated soon after birth, as it was shown that early introduction of ERT produced immune tolerance and improved enzyme effectiveness in the cat model. New insights on the pathophysiology of MPS disorders are leading to alternative therapeutic approaches, as gene therapy, inflammatory response modulators and substrate reduction therapy.

  4. Recent Advances in Treatment Approaches of Mucopolysaccharidosis VI.

    PubMed

    Giugliani, Roberto; Carvalho, Clarissa Gutiérrez; Herber, Silvani; de Camargo Pinto, Louise Lapagesse

    2011-06-01

    Mucopolysaccharidosis VI is caused by accumulation of the glycosaminoglycan dermatan sulfate in all tissues due to decreased activity of the enzyme arylsulfatase B. Patients exhibit multisystemic signs and symptoms in a chronic and progressive manner, especially with changes in the skeleton, cardiopulmonary system, cornea, skin, liver, spleen and meninges. Patients usually have normal intelligence. In the past, treatment of mucopolysaccharidoses was limited to palliative medical care. The outcome for affected patients improved with the introduction of new technologies as hematopoietic stem cell transplantation, relegated to specific situations after enzyme replacement therapy (ERT) became available. The specific ERT for MPS VI, galsulfase (Naglazyme®, Biomarin Pharmaceutical) was approved in 2005 by FDA and in 2006 by EMEA, and three clinical studies including 56 patients have evaluated the efficacy and safety. Long-term follow up data with patients treated up to 5 years showed that ERT is well tolerated and associated with sustained improvements in the patients' clinical condition. Intrathecal ERT may be considered in situations of high neurosurgical risk but still it is experimental in humans, as is intra-articular ERT. It is possible that the full impact of this therapy will only be demonstrated when patients are identified and treated soon after birth, as it was shown that early introduction of ERT produced immune tolerance and improved enzyme effectiveness in the cat model. New insights on the pathophysiology of MPS disorders are leading to alternative therapeutic approaches, as gene therapy, inflammatory response modulators and substrate reduction therapy. PMID:21506914

  5. [New approaches to the measurement of population internal spatial mobility].

    PubMed

    Courgeau, D

    1990-08-01

    This work argues for a new and broader approach to measurement of internal spatial mobility that would place it in the context of interaction with other social processes. Spatial mobility is not an isolated event that can be considered an independent variable; it is instead a process that can only be fully understood through its interaction with the other demographic, economic, political, and social elements that form part of the life of a human being. This work attempts to demonstrate the necessity of considering changes in these processes simultaneously, and briefly describes different methods of measurement. The study of migration has traditionally focused on a restricted concept of change of residence of individuals and has ignored other forms of population movement, such as commuting or repeated short-term movements not entailing permanent change of residence. Explanatory models of migration have been essentially cross-sectional, but a longitudinal approach is needed to analyze spatial mobility simultaneously with other events in the family and professional life. Retrospective studies may provide data on events in the past. They have the advantage of requiring only 1 visit, but the disadvantage that interviews may be quite lengthy. Some attempts to verify the quality of data collected in comprehensive retrospective biographical surveys in Belgium have yielded promising results. Respondents appear to remember the order of events better than the exact dates. It is more difficult to conduct retrospective surveys in developing countries because of the usual lack of population registers and other documentation. Prospective surveys appear more appropriate for obtaining longitudinal data on spatial mobility, but difficulties of following the sample for long periods of time then arise. Visits must be repeated at short enough intervals to avoid errors of memory, and arrangements must be made in advance for locating respondents who migrate. A hypothetical example of

  6. On the use of the systems approach to certify advanced aviation technologies

    NASA Technical Reports Server (NTRS)

    Wise, Mark A.; Wise, John A.

    1994-01-01

    The field of human factors is as varied and diverse as the human subject itself. But one of its most important applications is the facilitation of safety and efficiency in a particular working environment through the implementation of paradigms known about humans and their working relationship with machines and systems. During the period since World War II (which is often viewed as the birth of Human Factors) no area has been the subject of more human factors research than aviation. And in no time during that epoch is the influence of human factors more important, nor more imperative than it is today. As technology driven designs have been finding their way into the national airspace system (NAS), there has been growing concern within the aviation industry itself, the Federal Aviation Administration (FAA), and the general public for a means by which to certify complex systems and the advanced aviation technologies that will be responsible for transporting, directing, and maintaining our airborne travel. While it is widely agreed human factors certification is desirable, the philosophy that will underlie the approach is debatable. There are, in general, two different approaches to certification: (1) the top-down or systems approach; and, (2) the bottom-up or monadical approach. The top-down approach is characterized by the underlying assumption that certification can be best achieved by looking at the system as a whole, understanding its objectives and operating environment, then examining the constituent parts. In an aircraft cockpit, this would be accomplished by first examining what the aircraft is supposed to be (e.g., fighter, general aviation, passenger), identifying its operating environment (IFR, VMC, combat, etc.) and looking at the entire working system which includes the hardware, software, liveware and their interactions; then, evaluative measures can be applied to the subsystems (e.g., individual instruments, CRT displays, controls). The bottom

  7. Measurement of storage ring motion at the advanced light source

    SciTech Connect

    Krebs, G.F.

    1997-05-01

    The mechanical stability of the Advanced Light Source storage ring is examined over a period of 1.5 years from the point of view of floor motion. The storage ring beam position monitor stability is examined under various operating conditions.

  8. Defining Neighborhood Boundaries for Social Measurement: Advancing Social Work Research

    ERIC Educational Resources Information Center

    Foster, Kirk A.; Hipp, J. Aaron

    2011-01-01

    Much of the current neighborhood-based research uses variables aggregated on administrative boundaries such as zip codes, census tracts, and block groups. However, other methods using current technological advances in geographic sciences may broaden our ability to explore the spatial concentration of neighborhood factors affecting individuals and…

  9. Advances in Measurement of Skin Friction in Airflow

    NASA Technical Reports Server (NTRS)

    Brown, James L.; Naughton, Jonathan W.

    2006-01-01

    The surface interferometric skin-friction (SISF) measurement system is an instrument for determining the distribution of surface shear stress (skin friction) on a wind-tunnel model. The SISF system utilizes the established oil-film interference method, along with advanced image-data-processing techniques and mathematical models that express the relationship between interferograms and skin friction, to determine the distribution of skin friction over an observed region of the surface of a model during a single wind-tunnel test. In the oil-film interference method, a wind-tunnel model is coated with a thin film of oil of known viscosity and is illuminated with quasi-monochromatic, collimated light, typically from a mercury lamp. The light reflected from the outer surface of the oil film interferes with the light reflected from the oil-covered surface of the model. In the present version of the oil-film interference method, a camera captures an image of the illuminated model and the image in the camera is modulated by the interference pattern. The interference pattern depends on the oil-thickness distribution on the observed surface, and this distribution can be extracted through analysis of the image acquired by the camera. The oil-film technique is augmented by a tracer technique for observing the streamline pattern. To make the streamlines visible, small dots of fluorescentchalk/oil mixture are placed on the model just before a test. During the test, the chalk particles are embedded in the oil flow and produce chalk streaks that mark the streamlines. The instantaneous rate of thinning of the oil film at a given position on the surface of the model can be expressed as a function of the instantaneous thickness, the skin-friction distribution on the surface, and the streamline pattern on the surface; the functional relationship is expressed by a mathematical model that is nonlinear in the oil-film thickness and is known simply as the thin-oil-film equation. From the

  10. Measuring University Students' Approaches to Learning Statistics: An Invariance Study

    ERIC Educational Resources Information Center

    Chiesi, Francesca; Primi, Caterina; Bilgin, Ayse Aysin; Lopez, Maria Virginia; del Carmen Fabrizio, Maria; Gozlu, Sitki; Tuan, Nguyen Minh

    2016-01-01

    The aim of the current study was to provide evidence that an abbreviated version of the Approaches and Study Skills Inventory for Students (ASSIST) was invariant across different languages and educational contexts in measuring university students' learning approaches to statistics. Data were collected on samples of university students attending…

  11. Incorporation of a risk analysis approach for the nuclear fuel cycle advanced transparency framework.

    SciTech Connect

    Mendez, Carmen Margarita; York, David L.; Inoue, Naoko; Kitabata, Takuya; Vugrin, Eric D.; Vugrin, Kay White; Rochau, Gary Eugene; Cleary, Virginia D.

    2007-05-01

    Proliferation resistance features that reduce the likelihood of diversion of nuclear materials from the civilian nuclear power fuel cycle are critical for a global nuclear future. A framework that monitors process information continuously can demonstrate the ability to resist proliferation by measuring and reducing diversion risk, thus ensuring the legitimate use of the nuclear fuel cycle. The automation of new nuclear facilities requiring minimal manual operation makes this possible by generating instantaneous system state data that can be used to track and measure the status of the process and material at any given time. Sandia National Laboratories (SNL) and the Japan Atomic Energy Agency (JAEA) are working in cooperation to develop an advanced transparency framework capable of assessing diversion risk in support of overall plant transparency. The ''diversion risk'' quantifies the probability and consequence of a host nation diverting nuclear materials from a civilian fuel cycle facility. This document introduces the details of the diversion risk quantification approach to be demonstrated in the fuel handling training model of the MONJU Fast Reactor.

  12. New Approaches For Validating Satellite Global Precipitation Measurements

    NASA Technical Reports Server (NTRS)

    Smith, Eric A.; Einaudi, Franco (Technical Monitor)

    2001-01-01

    The scientific successes of the Tropical Rainfall Measuring Mission (TRMM) and additional recent satellite-focused precipitation retrieval projects, particularly those based on use of passive microwave radiometer measurements, have paved the way for a more advanced mission currently under development as the Global Precipitation Measurement (GPM) mission. This new mission is motivated by a number of scientific questions that TRMM research has posed over a range of space-time scales and within a variety of scientific disciplines that are becoming more integrated into earth system science modeling.

  13. Mortality Measurement at Advanced Ages: A Study of the Social Security Administration Death Master File

    PubMed Central

    Gavrilov, Leonid A.; Gavrilova, Natalia S.

    2011-01-01

    Accurate estimates of mortality at advanced ages are essential to improving forecasts of mortality and the population size of the oldest old age group. However, estimation of hazard rates at extremely old ages poses serious challenges to researchers: (1) The observed mortality deceleration may be at least partially an artifact of mixing different birth cohorts with different mortality (heterogeneity effect); (2) standard assumptions of hazard rate estimates may be invalid when risk of death is extremely high at old ages and (3) ages of very old people may be exaggerated. One way of obtaining estimates of mortality at extreme ages is to pool together international records of persons surviving to extreme ages with subsequent efforts of strict age validation. This approach helps researchers to resolve the third of the above-mentioned problems but does not resolve the first two problems because of inevitable data heterogeneity when data for people belonging to different birth cohorts and countries are pooled together. In this paper we propose an alternative approach, which gives an opportunity to resolve the first two problems by compiling data for more homogeneous single-year birth cohorts with hazard rates measured at narrow (monthly) age intervals. Possible ways of resolving the third problem of hazard rate estimation are elaborated. This approach is based on data from the Social Security Administration Death Master File (DMF). Some birth cohorts covered by DMF could be studied by the method of extinct generations. Availability of month of birth and month of death information provides a unique opportunity to obtain hazard rate estimates for every month of age. Study of several single-year extinct birth cohorts shows that mortality trajectory at advanced ages follows the Gompertz law up to the ages 102–105 years without a noticeable deceleration. Earlier reports of mortality deceleration (deviation of mortality from the Gompertz law) at ages below 100 appear to be

  14. Percutaneous Irreversible Electroporation of Locally Advanced Pancreatic Carcinoma Using the Dorsal Approach: A Case Report

    SciTech Connect

    Scheffer, Hester J. Melenhorst, Marleen C. A. M.; Vogel, Jantien A.; Tilborg, Aukje A. J. M. van; Nielsen, Karin Kazemier, Geert; Meijerink, Martijn R.

    2015-06-15

    Irreversible electroporation (IRE) is a novel image-guided ablation technique that is increasingly used to treat locally advanced pancreatic carcinoma (LAPC). We describe a 67-year-old male patient with a 5 cm stage III pancreatic tumor who was referred for IRE. Because the ventral approach for electrode placement was considered dangerous due to vicinity of the tumor to collateral vessels and duodenum, the dorsal approach was chosen. Under CT-guidance, six electrodes were advanced in the tumor, approaching paravertebrally alongside the aorta and inferior vena cava. Ablation was performed without complications. This case describes that when ventral electrode placement for pancreatic IRE is impaired, the dorsal approach could be considered alternatively.

  15. Alcohol Measurement Methodology in Epidemiology: Recent Advances and Opportunities

    PubMed Central

    Greenfield, Thomas K.; Kerr, William C.

    2009-01-01

    Aim To review and discuss measurement issues in survey assessment of alcohol consumption for epidemiological studies. Methods The following areas are considered: implications of cognitive studies of question answering like self-referenced schemata of drinking, reference period and retrospective recall, as well as the assets and liabilities of types of current (e.g., food frequency, quantity frequency, graduated frequencies, and heavy drinking indicators) and lifetime drinking measures. Finally we consider units of measurement and improving measurement by detailing the ethanol content of drinks in natural settings. Results and conclusions Cognitive studies suggest inherent limitations in the measurement enterprise, yet diary studies show promise of broadly validating methods that assess a range of drinking amounts per occasion; improvements in survey measures of drinking in the life course are indicated; attending in detail to on and off-premise drink pour sizes and ethanol concentrations of various beverages shows promise of narrowing the coverage gap plaguing survey alcohol measurement. PMID:18422826

  16. Exploring Advanced Piano Students' Approaches to Sight-Reading

    ERIC Educational Resources Information Center

    Zhukov, Katie

    2014-01-01

    The ability to read music fluently is fundamental for undergraduate music study yet the training of sight-reading is often neglected. This study compares approaches to sight-reading and accompanying by students with extensive sight-reading experience to those with limited experience, and evaluates the importance of this skill to advanced pianists…

  17. Evaluating New Approaches to Teaching of Sight-Reading Skills to Advanced Pianists

    ERIC Educational Resources Information Center

    Zhukov, Katie

    2014-01-01

    This paper evaluates three teaching approaches to improving sight-reading skills against a control in a large-scale study of advanced pianists. One hundred pianists in four equal groups participated in newly developed training programmes (accompanying, rhythm, musical style and control), with pre- and post-sight-reading tests analysed using…

  18. New approach for measuring the microwave Hall mobility of semiconductors

    SciTech Connect

    Murthy, D. V. B.; Subramanian, V.; Murthy, V. R. K.

    2006-06-15

    Measurement of Hall mobility in semiconductor samples using bimodal cavity method gives distinct advantages due to noncontact nature as well as the provision to measure anisotropic mobility. But the measurement approaches followed till now have a disadvantage of having high error values primarily due to the problem in evaluating the calibration constant of the whole experimental arrangement. This article brings out a new approach that removes such disadvantage and presents the calibration constant with 1% accuracy. The overall error in the carrier mobility values is within 5%.

  19. Performance Measurement of Advanced Stirling Convertors (ASC-E3)

    NASA Technical Reports Server (NTRS)

    Oriti, Salvatore M.

    2013-01-01

    NASA Glenn Research Center (GRC) has been supporting development of the Advanced Stirling Radioisotope Generator (ASRG) since 2006. A key element of the ASRG project is providing life, reliability, and performance testing data of the Advanced Stirling Convertor (ASC). The latest version of the ASC (ASC-E3, to represent the third cycle of engineering model test hardware) is of a design identical to the forthcoming flight convertors. For this generation of hardware, a joint Sunpower and GRC effort was initiated to improve and standardize the test support hardware. After this effort was completed, the first pair of ASC-E3 units was produced by Sunpower and then delivered to GRC in December 2012. GRC has begun operation of these units. This process included performance verification, which examined the data from various tests to validate the convertor performance to the product specification. Other tests included detailed performance mapping that encompassed the wide range of operating conditions that will exist during a mission. These convertors were then transferred to Lockheed Martin for controller checkout testing. The results of this latest convertor performance verification activity are summarized here.

  20. Advanced units: quality measures in urgency and emergency care

    PubMed Central

    Viola, Dan Carai Maia; Cordioli, Eduardo; Pedrotti, Carlos Henrique Sartorato; Iervolino, Mauro; Bastos, Antonio da Silva; de Almeida, Luis Roberto Natel; Neves, Henrique Sutton de Sousa; Lottenberg, Claudio Luiz

    2014-01-01

    Objective To evaluate, through care indicators, the quality of services rendered to patients considered urgency and emergency cases at an advanced emergency care unit. Methods We analyzed data from managerial reports of 64,891 medical visits performed in the Emergency Care Unit of the Ibirapuera Unit at Care during the period from June 1st, 2012 through May 31st, 2013. The proposed indicators for the assessment of care were rate of death in the emergency care unit; average length of stay of patients in the unit; rate of unplanned return visits; admission rate for patients screened as level 1 according to the Emergency Severity Index; rate of non-finalized medical consultations; rate of complaints; and door-to-electrocardiogram time. Results The rate of death in the emergency care unit was zero. Five of the 22 patients classified as Emergency Severity Index 1 (22.7%) arrived presenting cardiac arrest. All were treated with cardiopulmonary resuscitation and reestablishment of vital functions. The average length of stay of patients in the unit was 3 hours, 33 minutes, and 7 seconds. The rate of unscheduled return visits at the emergency care unit of the Ibirapuera unit was 13.64%. Rate of complaints was 2.8/1,000 patients seen during the period Conclusion The model of urgency and emergency care in advanced units provides an efficient and efficaious service to patients. Both critically ill patients and those considered less complex can receive proper treatment for their needs. PMID:25628203

  1. Waves and Wine: Advanced approaches for characterizing and exploiting micro-terroir

    NASA Astrophysics Data System (ADS)

    Hubbard, S. S.; Grote, K. R.; Freese, P.; Peterson, J. E.; Rubin, Y.

    2012-12-01

    Development of viticultural strategies that are focused on promoting uniformly high quality wine grapes requires an understanding of the properties that influence wine grape development. Our objective is to explore the spatial and temporal variability of above and below ground factors that can influence grape variability at the block scale (or micro-terroir) using a combination of conventional point measurements and non-invasive geophysical approaches, and to use that information to guide the development of new vineyards or the management of existing vineyards. Climate clearly plays a dominant role in determining the success of certain viticultural regions or vintages. However, wine grapes of the same variety, which are grown in the same microclimate region and cultivated and made into wine using identical practices, can lead to remarkably different wines when the grapes are grown on different types of soils. The soil texture controls soil water availability, which greatly influences grapevine physiological status, vegetative and reproductive growth, and ultimately red wine grape quality. One aspect of our research has focused on developing surface geophysical methods, particularly ground penetrating radar (GPR), to characterize soil texture variability and to monitor vineyard water content. Through testing the approaches in three California wineries, we find that analysis of GPR groundwave and reflected waves enable mapping of shallow soil water content in high resolution, with acceptable accuracy, and in a non-invasive manner, and that use of multiple GPR methods and frequencies offer the potential to characterize the soil in 3-D space. We use the dense data to explore spatial and temporal correlations in soil water content, soil texture, and vegetation vigor and the associated implications for vineyard management. We also describe a new zonal-based vineyard development strategy that honors the natural variability of the site, or the micro-terrior. The approach

  2. A new approach to high precision phase measurement interferometry

    NASA Astrophysics Data System (ADS)

    Balasubramanian, N.; Debell, G. W.

    1980-01-01

    A description is presented of a phase measuring interferometer system which represents a unique approach to the extraction and analysis of wavefront data from the interferometer output. In contrast to fringe pattern analysis systems, the digitally based instrument described is a direct phase measuring interferometer system which is capable of providing a graphical representation of both the sign and magnitude of the phase distribution across the test wavefront. Attention is given to basic theory, the instrument measurement head, the 8080-based computer used as a processor, system performance specifications, measurement precision and accuracy, and measurement capabilities.

  3. Advances in the Measurement of Atomic Transition Probabilities

    NASA Astrophysics Data System (ADS)

    O'Brian, Thomas Raymond

    The technology for measuring absolute atomic transition probabilities is extended. Radiative lifetimes are measured by time-resolved laser-induced fluorescence on a slow atomic beam generated by a versatile hollow cathode discharge source. The radiative lifetimes are free from systematic error at the five percent level. Combined with branching fractions measured with emission or absorption sources, the lifetimes result in absolute transition probabilities usually accurate to 5-10 %. Three new developments in the lifetime and branching fraction technique are reported. Radiative lifetimes for 186 levels in neutral iron are measured, with the energy of the upper levels densely spanning the entire excitation range of neutral iron. Combined with branching fractions measured in emission with Fourier transform spectrophotometry, the level lifetimes directly yield absolute transition probabilities for 1174 transitions. An additional 640 transition probabilities are determined by interpolating level populations in an emission source. The dense energy spacing of the levels with directly measured lifetimes permits accurate population interpolation despite departures from local thermodynamic equilibrium. This technique has the potential to permit accurate absolute transition probability measurements for essentially every classified line in a spectrum. Radiative lifetime measurements are extended into the vacuum ultraviolet with a continuously tunable vacuum ultraviolet laser based on stimulated anti-Stokes Raman scattering. When used with the hollow cathode atomic beam source, accurate lifetimes are measured for 47 levels in neutral silicon and 8 levels in neutral boron, primarily in the vacuum ultraviolet spectral region. Transition probabilities are reported for many lines connected to these upper levels, using previously measured or calculated branching fractions. The hollow cathode beam source is developed for use with refractory non-metals. Intense atomic beams of boron

  4. Advances in Raman Lidar Measurements of Water Vapor

    NASA Technical Reports Server (NTRS)

    Whiteman, D. N.; Evans, K.; Demoz, B.; DiGirolamo, P.; Mielke, B.; Stein, B.; Goldsmith, J. E. M.; Tooman, T.; Turner, D.; Starr, David OC. (Technical Monitor)

    2002-01-01

    Recent technology upgrades to the NASA/GSFC Scanning Raman Lidar have permitted significant improvements in the daytime and nighttime measurement of water vapor using Raman lidar. Numerical simulation has been used to study the temperature sensitivity of the narrow spectral band measurements presented here.

  5. Geographic differences in approach to advanced gastric cancer: Is there a standard approach?

    PubMed

    Kim, Richard; Tan, Ann; Choi, Minsig; El-Rayes, Bassel F

    2013-11-01

    Gastric cancer is one of the leading causes of cancer related deaths worldwide. Regional differences in gastric cancer are evident between Asian and Western societies with respect to etiology, prevalence, clinicopathologic features as well as treatment pattern of the disease. For patients with advanced gastric cancer (AGC), chemotherapy has been found to improve survival and quality of life compared to best supportive care alone. But contrast to other tumors such as colon or pancreatic cancer, there are regional differences in outcome in gastric cancer. Various geographic/ethnic, biology and treatment strategies may contribute to these differences. In the first line setting, cisplatin and fluoropyrimidine based therapies remain the backbone of treatment for advanced gastric cancer in Asian and Western patients, although there is preference for S1 in Asia and 5FU in the West. A third agent may be added in patients with good performance status. Recent trials from Asia and Europe demonstrate an advantage for second line chemotherapy. Irinotecan and taxanes are the most commonly used agents. The introduction of trastuzumab into the frontline therapy of AGC has ushered the age of targeted therapy and personalized medicine in this disease. In this article, we will review the various first and second line chemotherapy regimens in AGC, taking into account regional differences including potential biomarkers.

  6. Quantifying uncertainty in discharge measurements: A new approach

    USGS Publications Warehouse

    Kiang, J.E.; Cohn, T.A.; Mason, R.R.

    2009-01-01

    The accuracy of discharge measurements using velocity meters and the velocity-area method is typically assessed based on empirical studies that may not correspond to conditions encountered in practice. In this paper, a statistical approach for assessing uncertainty based on interpolated variance estimation (IVE) is introduced. The IVE method quantifies all sources of random uncertainty in the measured data. This paper presents results employing data from sites where substantial over-sampling allowed for the comparison of IVE-estimated uncertainty and observed variability among repeated measurements. These results suggest that the IVE approach can provide approximate estimates of measurement uncertainty. The use of IVE to estimate the uncertainty of a discharge measurement would provide the hydrographer an immediate determination of uncertainty and help determine whether there is a need for additional sampling in problematic river cross sections. ?? 2009 ASCE.

  7. Ultra-sensitive transducer advances micro-measurement range

    NASA Technical Reports Server (NTRS)

    Rogallo, V. L.

    1964-01-01

    An ultrasensitive piezoelectric transducer, that converts minute mechanical forces into electrical impulses, measures the impact of micrometeoroids against space vehicles. It has uniform sensitivity over the entire target area and a high degree of stability.

  8. Advances in bioanalytical techniques to measure steroid hormones in serum.

    PubMed

    French, Deborah

    2016-06-01

    Steroid hormones are measured clinically to determine if a patient has a pathological process occurring in the adrenal gland, or other hormone responsive organs. They are very similar in structure making them analytically challenging to measure. Additionally, these hormones have vast concentration differences in human serum adding to the measurement complexity. GC-MS was the gold standard methodology used to measure steroid hormones clinically, followed by radioimmunoassay, but that was replaced by immunoassay due to ease of use. LC-MS/MS has now become a popular alternative owing to simplified sample preparation than for GC-MS and increased specificity and sensitivity over immunoassay. This review will discuss these methodologies and some new developments that could simplify and improve steroid hormone analysis in serum. PMID:27217264

  9. Advances in measuring techniques for turbine cooling test rigs

    NASA Technical Reports Server (NTRS)

    Pollack, F. G.

    1972-01-01

    Surface temperature distribution measurements for turbine vanes and blades were obtained by measuring the infrared energy emitted by the airfoil. The IR distribution can be related to temperature distribution by suitable calibration methods and the data presented in the form of isotherm maps. Both IR photographic and real time electro-optical methods are being investigated. The methods can be adapted to rotating as well as stationary targets, and both methods can utilize computer processing. Pressure measurements on rotating components are made with a rotating system incorporating 10 miniature transducers. A mercury wetted slip ring assembly was used to supply excitation power and as a signal transfer device. The system was successfully tested up to speeds of 9000 rpm and is now being adapted to measure rotating blade airflow quantities in a spin rig and a research engine.

  10. Advances in bioanalytical techniques to measure steroid hormones in serum.

    PubMed

    French, Deborah

    2016-06-01

    Steroid hormones are measured clinically to determine if a patient has a pathological process occurring in the adrenal gland, or other hormone responsive organs. They are very similar in structure making them analytically challenging to measure. Additionally, these hormones have vast concentration differences in human serum adding to the measurement complexity. GC-MS was the gold standard methodology used to measure steroid hormones clinically, followed by radioimmunoassay, but that was replaced by immunoassay due to ease of use. LC-MS/MS has now become a popular alternative owing to simplified sample preparation than for GC-MS and increased specificity and sensitivity over immunoassay. This review will discuss these methodologies and some new developments that could simplify and improve steroid hormone analysis in serum.

  11. Advanced turboprop wing installation effects measured by unsteady blade pressure and noise

    NASA Technical Reports Server (NTRS)

    Heidelberg, Laurence J.; Woodward, Richard P.

    1987-01-01

    A single rotation model propeller (SR-7A) was tested at simulated takeoff/approach conditions (Mach 0.2), in the NASA Lewis 9- by 15-Ft Anechoic Wind Tunnel. Both unsteady blade surface pressures and noise measurements were made for a tractor configuration with propeller/straight wing and propeller alone configurations. The angle between the wing chord and propeller axis (droop angle) was varied along with the wing angle of attack to determine the effects on noise and unsteady loading. A method was developed that uses unsteady blade pressure measurements to provide a quantitative indication of propeller inflow conditions, at least for a uniform (across the propeller disk) inflow angle. The wing installation caused a nearly uniform upwash at the propeller inlet as evidenced by the domination of the pressure spectra by the first shaft order. This inflow angle increased at a rate of almost 150 percent of that of the wing angle-of-attack for a propeller-wing spacing of 0.54 wing chords at a constant droop angle. The flyover noise, as measured by the maximum blade passing frequency level, correlates closely with the propeller inflow angle (approx. 0.6 dB per degree of inflow angle) for all droop angles and wing angles of attack tested, including the propeller alone data. Large changes in the unsteady pressure responses on the suction surface of the blade were observed as the advance ratio was varied. The presence of a leading edge vortex may explain this behavior since changes in the location of this vortex would change with loading (advance ratio).

  12. Robust quantitative parameter estimation by advanced CMP measurements for vadose zone hydrological studies

    NASA Astrophysics Data System (ADS)

    Koyama, C.; Wang, H.; Khuut, T.; Kawai, T.; Sato, M.

    2015-12-01

    Soil moisture plays a crucial role in the understanding of processes in the vadose zone hydrology. In the last two decades ground penetrating radar (GPR) has been widely discussed has nondestructive measurement technique for soil moisture data. Especially the common mid-point (CMP) technique, which has been used in both seismic and GPR surveys to investigate the vertical velocity profiles, has a very high potential for quantitaive obervsations from the root zone to the ground water aquifer. However, the use is still rather limited today and algorithms for robust quantitative paramter estimation are lacking. In this study we develop an advanced processing scheme for operational soil moisture reetrieval at various depth. Using improved signal processing, together with a semblance - non-normalized cross-correlation sum combined stacking approach and the Dix formula, the interval velocities for multiple soil layers are obtained from the RMS velocities allowing for more accurate estimation of the permittivity at the reflecting point. Where the presence of a water saturated layer, like a groundwater aquifer, can be easily identified by its RMS velocity due to the high contrast compared to the unsaturated zone. By using a new semi-automated measurement technique the acquisition time for a full CMP gather with 1 cm intervals along a 10 m profile can be reduced significantly to under 2 minutes. The method is tested and validated under laboratory conditions in a sand-pit as well as on agricultural fields and beach sand in the Sendai city area. Comparison between CMP estimates and TDR measurements yield a very good agreement with RMSE of 1.5 Vol.-%. The accuracy of depth estimation is validated with errors smaller than 2%. Finally, we demonstrate application of the method in a test site in semi-arid Mongolia, namely the Orkhon River catchment in Bulgan, using commercial 100 MHz and 500 MHz RAMAC GPR antennas. The results demonstrate the suitability of the proposed method for

  13. Advances in Swept-Wavelength Interferometry for Precision Measurements

    NASA Astrophysics Data System (ADS)

    Moore, Eric D.

    2011-12-01

    Originally developed for radar applications in the 1950s, swept-wavelength interferometry (SWI) at optical wavelengths has been an active area of research for the past thirty years, with applications in fields ranging from fiber optic telecommunications to biomedical imaging. It now forms the basis of several measurement techniques, including optical frequency domain reflectometry (OFDR), swept-source optical coherence tomography (SS-OCT), and frequency-modulated continuous-wave (FMCW) lidar. In this thesis, I present several novel contributions to the field of SWI that include improvements and extensions to the state of the art in SWI for performing precision measurements. The first is a method for accurately monitoring the instantaneous frequency of the tunable source to accommodate nonlinearities in the source tuning characteristics. This work ex- tends the commonly used method incorporating an auxiliary interferometer to the increasingly relevant cases of long interferometer path mismatches and high-speed wavelength tuning. The second contribution enables precision absolute range measurements to within a small fraction of the transform-limited range resolution of the SWI system. This is accomplished through the use of digital filtering in the time domain and phase slope estimation in the frequency domain. Measurements of optical group delay with attosecond-level precision are experimentally demonstrated and applied to measurements of group refractive index and physical thickness. The accuracy of the group refractive index measurement is shown to be on the order of 10-6, while measurements of absolute thicknesses of macroscopic samples are accomplished with accuracy on the order of 10 nm. Furthermore, sub-nanometer uncertainty for relative thickness measurements can be achieved. For the case of crystalline silicon wafers, the achievable uncertainty is on the same order as the Si-Si bond length, opening the door to potential thickness profiling with single atomic

  14. Comparison of Thermal Modeling Approaches for Complex Measurement Equipment

    NASA Astrophysics Data System (ADS)

    Schalles, M.; Thewes, R.

    2014-04-01

    Thermal modeling is used for thermal investigation and optimization of sensors, instruments, and structures. Here, results depend on the chosen modeling approach, the complexity of the model, the quality of material data, and the information about the heat transport conditions of the object of investigation. Despite the widespread application, the advantages and limits of the modeling approaches are partially unknown. For comparison of different modeling approaches, a simplified and analytically describable demonstration object is used. This object is a steel rod at well-defined heat exchange conditions with the environment. For this, analytically describable models, equivalent electrical circuits, and simple and complex finite-element-analysis models are presented. Using the different approaches, static and dynamic simulations are performed and temperatures and temperature fields in the rod are estimated. The results of those calculations, comparisons with measurements, and identification of the sensitive points of the approaches are shown. General conclusions for thermal modeling of complex equipment are drawn.

  15. Precise Radio-Telescope Measurements Advance Frontier Gravitational Physics

    NASA Astrophysics Data System (ADS)

    2009-09-01

    Scientists using a continent-wide array of radio telescopes have made an extremely precise measurement of the curvature of space caused by the Sun's gravity, and their technique promises a major contribution to a frontier area of basic physics. "Measuring the curvature of space caused by gravity is one of the most sensitive ways to learn how Einstein's theory of General Relativity relates to quantum physics. Uniting gravity theory with quantum theory is a major goal of 21st-Century physics, and these astronomical measurements are a key to understanding the relationship between the two," said Sergei Kopeikin of the University of Missouri. Kopeikin and his colleagues used the National Science Foundation's Very Long Baseline Array (VLBA) radio-telescope system to measure the bending of light caused by the Sun's gravity to an accuracy of 0.03 percent. With further observations, the scientists say their precision technique can make the most accurate measure ever of this phenomenon. Bending of starlight by gravity was predicted by Albert Einstein when he published his theory of General Relativity in 1916. According to relativity theory, the strong gravity of a massive object such as the Sun produces curvature in the nearby space, which alters the path of light or radio waves passing near the object. The phenomenon was first observed during a solar eclipse in 1919. Though numerous measurements of the effect have been made over the intervening 90 years, the problem of merging General Relativity and quantum theory has required ever more accurate observations. Physicists describe the space curvature and gravitational light-bending as a parameter called "gamma." Einstein's theory holds that gamma should equal exactly 1.0. "Even a value that differs by one part in a million from 1.0 would have major ramifications for the goal of uniting gravity theory and quantum theory, and thus in predicting the phenomena in high-gravity regions near black holes," Kopeikin said. To make

  16. ATWS Analysis with an Advanced Boiling Curve Approach within COBRA 3-CP

    SciTech Connect

    Gensler, A.; Knoll, A.; Kuehnel, K.

    2007-07-01

    In 2005 the German Reactor Safety Commission issued specific requirements on core coolability demonstration for PWR ATWS (anticipated transients without scram). Thereupon AREVA NP performed detailed analyses for all German PWRs. For a German KONVOI plant the results of an ATWS licensing analysis are presented. The plant dynamic behavior is calculated with NLOOP, while the hot channel analysis is performed with the thermal hydraulic computer code COBRA 3-CP. The application of the fuel rod model included in COBRA 3-CP is essential for this type of analysis. Since DNB (departure from nucleate boiling) occurs, the advanced post DNB model (advanced boiling curve approach) of COBRA 3-CP is used. The results are compared with those gained with the standard BEEST model. The analyzed ATWS case is the emergency power case 'loss of main heat sink with station service power supply unavailable'. Due to the decreasing coolant flow rate during the transient the core attains film boiling conditions. The results of the hot channel analysis strongly depend on the performance of the boiling curve model. The BEEST model is based on pool boiling conditions whereas typical PWR conditions - even in most transients - are characterized by forced flow for which the advanced boiling curve approach is particularly suitable. Compared with the BEEST model the advanced boiling curve approach in COBRA 3-CP yields earlier rewetting, i.e. a shorter period in film boiling. Consequently, the fuel rod cladding temperatures, that increase significantly due to film boiling, drop back earlier and the high temperature oxidation is significantly diminished. The Baker-Just-Correlation was used to calculate the value of equivalent cladding reacted (ECR), i.e. the reduction of cladding thickness due to corrosion throughout the transient. Based on the BEEST model the ECR value amounts to 0.4% whereas the advanced boiling curve only leads to an ECR value of 0.2%. Both values provide large margins to the 17

  17. Recent Advances in Global Measurement and Application of River Widths

    NASA Astrophysics Data System (ADS)

    Pavelsky, T.; Allen, G. H.

    2015-12-01

    Among variables relevant to river form and discharge that can be observed from space, river width is perhaps the simplest to measure. Width can be extracted directly from optical or radar imagery, and application of remotely sensed widths to problems in hydrology, fluvial geomorphology, and ecology dates back more than two decades. Despite this long heritage, until very recently remotely sensed width measurements have largely been made on an ad-hoc basis for individual studies over relatively small regions. Global studies that required river widths have largely relied on estimates from downstream hydraulic geometry relationships with basin area, which inevitably simplify width variability and may, in practice, underestimate the fraction of wide rivers and the total river surface area in many basins. Over the last two years, multiple new regional- and global-scale, satellite-derived river width datasets have been developed that have substantially improved our global understanding of river form. These datasets include the Global Width Database for Large Rivers (GWD-LR), which provides width measurements for rivers wider than ~180 m, and all rivers wider than ~300 m, based on the SRTM water mask and the Global River Widths from Landsat (GRWL), which provides measurements for rivers as narrow as 30 m and all rivers wider than ~100 m. Several regional-scale datasets have also been developed. These datasets will facilitate improvements to regional and global scale hydrodynamic models, will provide more robust information on global river surface area for gas flux studies, and constitute novel information on global patterns of fluvial geomorphology. These datasets represent the beginning, not the end, of global river width measurements, however, as in the future multitemporal width measurements can be combined with recently developed algorithms to estimate river discharge for many rivers, globally.

  18. Recent Advances in Spaceborne Precipitation Radar Measurement Techniques and Technology

    NASA Technical Reports Server (NTRS)

    Im, Eastwood; Durden, Stephen L.; Tanelli, Simone

    2006-01-01

    NASA is currently developing advanced instrument concepts and technologies for future spaceborne atmospheric radars, with an over-arching objective of making such instruments more capable in supporting future science needs and more cost effective. Two such examples are the Second-Generation Precipitation Radar (PR-2) and the Nexrad-In-Space (NIS). PR-2 is a 14/35-GHz dual-frequency rain radar with a deployable 5-meter, wide-swath scanned membrane antenna, a dual-polarized/dual-frequency receiver, and a realtime digital signal processor. It is intended for Low Earth Orbit (LEO) operations to provide greatly enhanced rainfall profile retrieval accuracy while consuming only a fraction of the mass of the current TRMM Precipitation Radar (PR). NIS is designed to be a 35-GHz Geostationary Earth Orbiting (GEO) radar for providing hourly monitoring of the life cycle of hurricanes and tropical storms. It uses a 35-m, spherical, lightweight membrane antenna and Doppler processing to acquire 3-dimensional information on the intensity and vertical motion of hurricane rainfall.

  19. Advances in laser-based isotope ratio measurements: selected applications

    NASA Astrophysics Data System (ADS)

    Kerstel, E.; Gianfrani, L.

    2008-09-01

    Small molecules exhibit characteristic ro-vibrational transitions in the near- and mid-infrared spectral regions, which are strongly influenced by isotopic substitution. This gift of nature has made it possible to use laser spectroscopy for the accurate analysis of the isotopic composition of gaseous samples. Nowadays, laser spectroscopy is clearly recognized as a valid alternative to isotope ratio mass spectrometry. Laser-based instruments are leaving the research laboratory stage and are being used by a growing number of isotope researchers for significant advances in their own field of research. In this review article, we discuss the current status and new frontiers of research on high-sensitivity and high-precision laser spectroscopy for isotope ratio analyses. Although many of our comments will be generally applicable to laser isotope ratio analyses in molecules of environmental importance, this paper concerns itself primarily with water and carbon dioxide, two molecules that were studied extensively in our respective laboratories. A complete coverage of the field is practically not feasible in the space constraints of this issue, and in any case doomed to fail, considering the large body of work that has appeared ever since the review by Kerstel in 2004 ( Handbook of Stable Isotope Analytical Techniques, Chapt. 34, pp. 759-787).

  20. Measurement and modeling of advanced coal conversion processes

    SciTech Connect

    Solomon, P.R.; Serio, M.A.; Hamblen, D.G. ); Smoot, L.D.; Brewster, B.S. )

    1992-01-01

    The objectives of this proposed study are to establish the mechanisms and rates of basic steps in coal conversion processes, to integrate and incorporate this information into comprehensive computer models for coal conversion processes, to evaluate these models and to apply them to gasification, mild gasification and combustion in heat engines. This report describes progress during twenty second quarter of the program. Specifically, the paper discusses progress in three task areas: (1) Submodel development and evaluation: coal to char chemistry submodel; fundamental high-pressure reaction rate data; secondary reaction of pyrolysis product and burnout submodels; ash physics and chemistry submodel; large particle submodels; large char particle oxidation at high pressures; and SO[sub x]-NO[sub x] submodel development and evaluation; (2) Comprehensive model development and evaluation: integration of advanced submodels into entrained-flow code, with evaluation and documentation; comprehensive fixed-bed modeling review, development evaluation and implementation; and generalized fuels feedstock submodel; and (3) Application of integrated codes: application of generalized pulverized coal comprehensive code and application of fixed-bed code.

  1. Precise Nuclear Data Measurements Possible with the NIFFTE fissionTPC for Advanced Reactor Designs

    NASA Astrophysics Data System (ADS)

    Towell, Rusty; Niffte Collaboration

    2015-10-01

    The Neutron Induced Fission Fragment Tracking Experiment (NIFFTE) Collaboration has applied the proven technology of Time Projection Chambers (TPC) to the task of precisely measuring fission cross sections. With the NIFFTE fission TPC, precise measurements have been made during the last year at the Los Alamos Neutron Science Center from both U-235 and Pu-239 targets. The exquisite tracking capabilities of this device allow the full reconstruction of charged particles produced by neutron beam induced fissions from a thin central target. The wealth of information gained from this approach will allow systematics to be controlled at the level of 1%. The fissionTPC performance will be presented. These results are critical to the development of advanced uranium-fueled reactors. However, there are clear advantages to developing thorium-fueled reactors such as Liquid Fluoride Thorium Reactors over uranium-fueled reactors. These advantages include improved reactor safety, minimizing radioactive waste, improved reactor efficiency, and enhanced proliferation resistance. The potential for using the fissionTPC to measure needed cross sections important to the development of thorium-fueled reactors will also be discussed.

  2. Advances in the Conceptualization and Measurement of Critical Consciousness

    ERIC Educational Resources Information Center

    Diemer, Matthew A.; McWhirter, Ellen Hawley; Ozer, Emily J.; Rapa, Luke J.

    2015-01-01

    This article reviews three emergent measures of critical consciousness (CC), which refers to marginalized or oppressed people's critical reflection on oppressive social, economic, or political conditions, the motivation to address perceived injustice, and action taken to counter such injustice in a liberatory manner (Freire in "Education for…

  3. Advances in soil erosion research: processes, measurement, and modeling

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Soil erosion by the environmental agents of water and wind is a continuing global menace that threatens the agricultural base that sustains our civilization. Members of ASABE have been at the forefront of research to understand erosion processes, measure erosion and related processes, and model very...

  4. Advanced intensity-modulation continuous-wave lidar techniques for ASCENDS CO2 column measurements

    NASA Astrophysics Data System (ADS)

    Campbell, Joel F.; Lin, Bing; Nehrir, Amin R.; Harrison, F. W.; Obland, Michael D.; Meadows, Byron

    2015-10-01

    Global atmospheric carbon dioxide (CO2) measurements for the NASA Active Sensing of CO2 Emissions over Nights, Days, and Seasons (ASCENDS) space mission are critical for improving our understanding of global CO2 sources and sinks. Advanced Intensity- Modulated Continuous-Wave (IM-CW) lidar techniques are investigated as a means of facilitating CO2 measurements from space to meet the ASCENDS measurement requirements. In recent numerical, laboratory and flight experiments we have successfully used the Binary Phase Shift Keying (BPSK) modulation technique to uniquely discriminate surface lidar returns from intermediate aerosol and cloud contamination. We demonstrate the utility of BPSK to eliminate sidelobes in the range profile as a means of making Integrated Path Differential Absorption (IPDA) column CO2 measurements in the presence of optically thin clouds, thereby eliminating the need to correct for sidelobe bias errors caused by the clouds. Furthermore, high accuracy and precision ranging to the surface as well as to the top of intermediate cloud layers, which is a requirement for the inversion of column CO2 number density measurements to column CO2 mixing ratios, has been demonstrated using new hyperfine interpolation techniques that takes advantage of the periodicity of the modulation waveforms. This approach works well for both BPSK and linear swept-frequency modulation techniques. The BPSK technique under investigation has excellent auto-correlation properties while possessing a finite bandwidth. A comparison of BPSK and linear swept-frequency is also discussed in this paper. These results are extended to include Richardson-Lucy deconvolution techniques to extend the resolution of the lidar beyond that implied by limit of the bandwidth of the modulation, where it is shown useful for making tree canopy measurements.

  5. Advanced Intensity-Modulation Continuous-Wave Lidar Techniques for ASCENDS O2 Column Measurements

    NASA Technical Reports Server (NTRS)

    Campbell, Joel F.; Lin, Bing; Nehrir, Amin R.; Harrison, F. Wallace; Obland, Michael D.; Meadows, Byron

    2015-01-01

    Global atmospheric carbon dioxide (CO2) measurements for the NASA Active Sensing of CO2 Emissions over Nights, Days, and Seasons (ASCENDS) space mission are critical for improving our understanding of global CO2 sources and sinks. Advanced Intensity- Modulated Continuous-Wave (IM-CW) lidar techniques are investigated as a means of facilitating CO2 measurements from space to meet the ASCENDS measurement requirements. In recent numerical, laboratory and flight experiments we have successfully used the Binary Phase Shift Keying (BPSK) modulation technique to uniquely discriminate surface lidar returns from intermediate aerosol and cloud contamination. We demonstrate the utility of BPSK to eliminate sidelobes in the range profile as a means of making Integrated Path Differential Absorption (IPDA) column CO2 measurements in the presence of optically thin clouds, thereby eliminating the need to correct for sidelobe bias errors caused by the clouds. Furthermore, high accuracy and precision ranging to the surface as well as to the top of intermediate cloud layers, which is a requirement for the inversion of column CO2 number density measurements to column CO2 mixing ratios, has been demonstrated using new hyperfine interpolation techniques that takes advantage of the periodicity of the modulation waveforms. This approach works well for both BPSK and linear swept-frequency modulation techniques. The BPSK technique under investigation has excellent auto-correlation properties while possessing a finite bandwidth. A comparison of BPSK and linear swept-frequency is also discussed in this paper. These results are extended to include Richardson-Lucy deconvolution techniques to extend the resolution of the lidar beyond that implied by limit of the bandwidth of the modulation, where it is shown useful for making tree canopy measurements.

  6. Advanced Laser Based Measurements in Porous Media Combustion

    NASA Technical Reports Server (NTRS)

    Tedder, Sarah A.

    2009-01-01

    We present measurements using dual-pump dual-broadband coherent anti-Stokes Raman scattering spectroscopy (DP-DBB-CARS) inside a porous media burner. This work continues our previous measurements in such combustion systems. The existing setup was significantly modified with the aim of providing improved data quality and data rate, reduction of interferences and additional species information. These changes are presented and discussed in detail. The CARS technique was expanded to a dual-pump dual-broadband CARS system which in principle enables acquisition of temperatures together with relative H2/N2- and O2/N2- species concentrations. Experimental complexity was reduced by the use of a modified spectrometer enabling the detection of both signals, vibrational and rotational CARS, with only one detection system.

  7. Advanced coordinate measuring machine at Sandia National Laboratories

    NASA Astrophysics Data System (ADS)

    Pilkey, R. D.; Klevgard, P. A.

    1993-03-01

    Sandia National Laboratories/California has acquired a new Moore M-48V CNC five-axis universal coordinate measuring machine (CMM). Site preparation, acceptance testing, and initial performance results are discussed. Unique features of the machine include a ceramic ram and vacuum evacuated laser pathways (VELPS). The implementation of a VELPS system on the machine imposed certain design requirements and entailed certain start-up problems. The machine's projected capabilities, workload, and research possibilities are outlined.

  8. Advanced coordinate measuring machine at Sandia National Laboratories/California

    SciTech Connect

    Pilkey, R.D.; Klevgard, P.A.

    1993-03-01

    Sandia National Laboratories/California has acquired a new Moore M-48V CNC five-axis universal coordinate measuring machine (CMM). Site preparation, acceptance testing, and initial performance results are discussed. Unique features of the machine include a ceramic ram and vacuum evacuated laser pathways (VELPS). The implementation of a VELPS system on the machine imposed certain design requirements and entailed certain start-up problems. The machine's projected capabilities, workload, and research possibilities are outlined.

  9. Advanced coordinate measuring machine at Sandia National Laboratories/California

    SciTech Connect

    Pilkey, R.D.; Klevgard, P.A.

    1993-03-01

    Sandia National Laboratories/California has acquired a new Moore M-48V CNC five-axis universal coordinate measuring machine (CMM). Site preparation, acceptance testing, and initial performance results are discussed. Unique features of the machine include a ceramic ram and vacuum evacuated laser pathways (VELPS). The implementation of a VELPS system on the machine imposed certain design requirements and entailed certain start-up problems. The machine`s projected capabilities, workload, and research possibilities are outlined.

  10. Advanced optical smoke meters for jet engine exhaust measurement

    NASA Technical Reports Server (NTRS)

    Pitz, R. W.

    1986-01-01

    Smoke meters with increased sensitivity, improved accuracy, and rapid response are needed to measure the smoke levels emitted by modern jet engines. The standard soiled tape meter in current use is based on filtering, which yields long term averages and is insensitive to low smoke levels. Two new optical smoke meter techniques that promise to overcome these difficulties have been experimentally evaluated: modulated transmission (MODTRAN) and photothermal deflection spectroscopy (PDS). Both techniques are based on light absorption by smoke, which is closely related to smoke density. They are variations on direct transmission measurements which produce a modulated signal that can be easily measured with phase sensitive detection. The MODTRAN and PDS techniques were tested on low levels of smoke and diluted samples of NO2 in nitrogen, simulating light adsorption due to smoke. The results are evaluated against a set of ideal smoke meter criteria that include a desired smoke measurement range of 0.1 to 12 mg cu.m. (smoke numbers of 1 to 50) and a frequency response of 1 per second. The MODTRAN instrument is found to be inaccurate for smoke levels below 3 mg/cu.m. and is able to make a only about once every 20 seconds because of its large sample cell. The PDS instrument meets nearly all the characteristics of an ideal smoke meter: it has excellent sensitivity over a range of smoke levels from 0.1 to 20 mg/cu.m. (smoke numbers of 1 to 60) and good frequency response (1 per second).

  11. Measuring the health of populations: the veil of ignorance approach.

    PubMed

    Pinto-Prades, José-Luis; Abellán-Perpiñán, José-María

    2005-01-01

    We report the results from two surveys designed to explore whether an application of Harsanyi's principle of choice form behind a veil of ignorance (VEI) can be used in order to measure the health of populations. This approach was tentatively recommended by Murray et al. (Bull. World Health Organ 2000; 78: 981-994; Summary Measures of population health: Concepts, Ethics, Measurement and Applications, WHO, 2002.) as an appropriate way of constructing summary measures of population health (SMPH) for comparative purposes. The operationalization of the VEI approach used in this paper was suggested by Nord (Summary Measures of Population Health: Concepts, Ethics, Measurement and Applications, WHO, 2002.). We test if VEI and person trade-off (PTO) methods generate similar quality-of-life weights. In addition, we compare VEI and PTO weights with individual utilities estimated by means of the conventional standard gamble (SG) and a variation of it we call double gamble. Finally, psychometric properties like feasibility, reliability, and consistency are examined. Our main findings are next: (1) VEI and PTO approaches generate very different weights; (2) it seems that differences between PTO and VEI are not due to the 'rule of rescue'; (3) the VEI resembled more a DG than a classical SG; (4) PTO, VEI, and DG exhibited good feasibility, reliability and consistency.

  12. Advances in Patient-Reported Outcomes: The NIH PROMIS® Measures

    PubMed Central

    Broderick, Joan E.; DeWitt, Esi Morgan; Rothrock, Nan; Crane, Paul K.; Forrest, Christopher B.

    2013-01-01

    Patient-reported outcomes (PRO) are questionnaire measures of patients’ symptoms, functioning, and health-related quality of life. They are designed to provide important clinical information that generally cannot be captured with objective medical testing. In 2004, the National Institutes of Health launched a research initiative to improve the clinical research enterprise by developing state-of-the-art PROs. The NIH Patient-Reported Outcomes Measurement System (PROMIS) and Assessment Center are the products of that initiative. Adult, pediatric, and parent-proxy item banks have been developed by using contemporary psychometric methods, yielding rapid, accurate measurements. PROMIS currently provides tools for assessing physical, mental, and social health using short-form and computer-adaptive testing methods. The PROMIS tools are being adopted for use in clinical trials and translational research. They are also being introduced in clinical medicine to assess a broad range of disease outcomes. Recent legislative developments in the United States support greater efforts to include patients’ reports of health experience in order to evaluate treatment outcomes, engage in shared decision-making, and prioritize the focus of treatment. PROs have garnered increased attention by the Food and Drug Administration (FDA) for evaluating drugs and medical devices. Recent calls for comparative effectiveness research favor inclusion of PROs. PROs could also potentially improve quality of care and disease outcomes, provide patient-centered assessment for comparative effectiveness research, and enable a common metric for tracking outcomes across providers and medical systems. PMID:25848562

  13. Advanced wavefront measurement and analysis of laser system modeling

    SciTech Connect

    Wolfe, C.R.; Auerback, J.M.

    1994-11-15

    High spatial resolution measurements of the reflected or transmitted wavefronts of large aperture optical components used in high peak power laser systems is now possible. These measurements are produced by phase shifting interferometry. The wavefront data is in the form of 3-D phase maps that reconstruct the wavefront shape. The emphasis of this work is on the characterization of wavefront features in the mid-spatial wavelength range (from 0.1 to 10.0 mm) and has been accomplished for the first time. Wavefront structure from optical components with spatial wavelengths in this range are of concern because their effects in high peak power laser systems. At high peak power, this phase modulation can convert to large magnitude intensity modulation by non-linear processes. This can lead to optical damage. We have developed software to input the measured phase map data into beam propagation codes in order to model this conversion process. We are analyzing this data to: (1) Characterize the wavefront structure produced by current optical components, (2) Refine our understanding of laser system performance, (3) Develop a database from which future optical component specifications can be derived.

  14. Advanced structural analysis of nanoporous materials by thermal response measurements.

    PubMed

    Oschatz, Martin; Leistner, Matthias; Nickel, Winfried; Kaskel, Stefan

    2015-04-01

    Thermal response measurements based on optical adsorption calorimetry are presented as a versatile tool for the time-saving and profound characterization of the pore structure of porous carbon-based materials. This technique measures the time-resolved temperature change of an adsorbent during adsorption of a test gas. Six carbide and carbon materials with well-defined nanopore architecture including micro- and/or mesopores are characterized by thermal response measurements based on n-butane and carbon dioxide as the test gases. With this tool, the pore systems of the model materials can be clearly distinguished and accurately analyzed. The obtained calorimetric data are correlated with the adsorption/desorption isotherms of the materials. The pore structures can be estimated from a single experiment due to different adsorption enthalpies/temperature increases in micro- and mesopores. Adsorption/desorption cycling of n-butane at 298 K/1 bar with increasing desorption time allows to determine the pore structure of the materials in more detail due to different equilibration times. Adsorption of the organic test gas at selected relative pressures reveals specific contributions of particular pore systems to the increase of the temperature of the samples and different adsorption mechanisms. The use of carbon dioxide as the test gas at 298 K/1 bar provides detailed insights into the ultramicropore structure of the materials because under these conditions the adsorption of this test gas is very sensitive to the presence of pores smaller than 0.7 nm. PMID:25773383

  15. Two Approaches to Measuring Task Interdependence in Elementary Schools.

    ERIC Educational Resources Information Center

    Charters, W. W., Jr.

    This report compares two approaches to measuring task interdependence, a theoretically fruitful concept for analyzing an organization's technical system. Task interdependence exists among operating personnel in the degree that task performance of one operative constrains, augments, or otherwise poses contingencies for the performance of another.…

  16. Global Precipitation Measurement: GPM Microwave Imager (GMI) Algorithm Development Approach

    NASA Technical Reports Server (NTRS)

    Stocker, Erich Franz

    2009-01-01

    This slide presentation reviews the approach to the development of the Global Precipitation Measurement algorithm. This presentation includes information about the responsibilities for the development of the algorithm, and the calibration. Also included is information about the orbit, and the sun angle. The test of the algorithm code will be done with synthetic data generated from the Precipitation Processing System (PPS).

  17. An Approach to Measuring Cognitive Outcomes across Higher Education Institutions

    ERIC Educational Resources Information Center

    Klein, Stephen P.; Kuh, George; Chun, Marc; Hamilton, Laura; Shavelson, Richard

    2005-01-01

    Over the past decade, state legislatures have experienced increasing pressure to hold higher education accountable for student learning. This pressure stems from several sources, such as increasing costs and decreasing graduation rates. To explore the feasibility of one approach to measuring student learning that emphasizes program improvement, we…

  18. Comparison of Two Analysis Approaches for Measuring Externalized Mental Models

    ERIC Educational Resources Information Center

    Al-Diban, Sabine; Ifenthaler, Dirk

    2011-01-01

    Mental models are basic cognitive constructs that are central for understanding phenomena of the world and predicting future events. Our comparison of two analysis approaches, SMD and QFCA, for measuring externalized mental models reveals different levels of abstraction and different perspectives. The advantages of the SMD include possibilities…

  19. Approaches to Measuring and Understanding Employer Training Expenditure: Support Document

    ERIC Educational Resources Information Center

    Smith, Andrew; Burke, Gerald; Long, Michael; Dumbrell, Tom

    2008-01-01

    This support document was produced by the authors based on their research for the report "Approaches to Measuring and Understanding Employer Training Expenditure," and is an added resource for further information. As outlined in the report, the research for this study was based on interviews and case studies, analysis of other research and a…

  20. THE DUAL-FOCUS APPROACH TO CREATING BILINGUAL MEASURES

    PubMed Central

    ERKUT, SUMRU; ALARCÓN, ODETTE; GARCÍA COLL, CYNTHIA; TROPP, LINDA R.; GARCÍA, HEIDIE A. VÁZQUEZ

    2011-01-01

    The dual-focus approach to creating bilingual research protocols requires a bilingual/bicultural research team, including indigenous researchers from the cultures being studied. The presence of indigenous researchers as full and equal members of the research team can guard against an unexamined exportation of ideas and methods developed in one culture to other cultural/linguistic communities. The team develops the research plan and a research protocol that express a given concept with equal clarity, affect, and level of usage simultaneously in two languages. The dual-focus method employs a concept-driven rather than a translation-driven approach to attain conceptual and linguistic equivalence. Examples of the application of this approach to creating new measures in Spanish and English, adapting existing measures, revising instructions to research participants, and correcting official translations are provided. PMID:21552397

  1. Two-phase flow measurements with advanced instrumented spool pieces

    SciTech Connect

    Turnage, K.C.

    1980-09-01

    A series of two-phase, air-water and steam-water tests performed with instrumented piping spool pieces is described. The behavior of the three-beam densitometer, turbine meter, and drag flowmeter is discussed in terms of two-phase models. Results from application of some two-phase mass flow models to the recorded spool piece data are shown. Results of the study are used to make recommendations regarding spool piece design, instrument selection, and data reduction methods to obtain more accurate measurements of two-phase flow parameters. 13 refs., 23 figs., 1 tab.

  2. ADVANCES TOWARDS THE MEASUREMENT AND CONTROL LHC TUNE AND CHROMATICITY

    SciTech Connect

    CAMERON, P.; CUPOLO, J.; DEGEN, C.; DELLAPENNA, A.; HOFF, L.; MEAD, J.; SIKORA, R.

    2005-06-06

    Requirements for tune and chromaticity control in most superconducting hadron machines, and in particular the LHC, are stringent. In order to reach nominal operation, the LHC will almost certainly require feedback on both tune and chromaticity. Experience at RHIC has also shown that coupling control is crucial to successful tune feedback. A prototype baseband phase-locked loop (PLL) tune measurement system has recently been brought into operation at RHIC as part of the US LHC Accelerator Research Program (LARP). We report on the performance of that system and compare it with the extensive accumulation of data from the RHIC 245MHz PLL.

  3. Advanced Intensity-Modulation Continuous-Wave Lidar Techniques for Column CO2 Measurements

    NASA Astrophysics Data System (ADS)

    Campbell, J. F.; Lin, B.; Nehrir, A. R.; Obland, M. D.; Liu, Z.; Browell, E. V.; Chen, S.; Kooi, S. A.; Fan, T. F.

    2015-12-01

    Global and regional atmospheric carbon dioxide (CO2) measurements for the NASA Active Sensing of CO2 Emissions over Nights, Days, and Seasons (ASCENDS) space mission and Atmospheric Carbon and Transport (ACT) - America airborne investigation are critical for improving our understanding of global CO2 sources and sinks. Advanced Intensity-Modulated Continuous-Wave (IM-CW) lidar techniques are being investigated as a means of facilitating CO2 measurements from space and airborne platforms to meet the mission science measurement requirements. In recent numerical, laboratory and flight experiments we have successfully used the Binary Phase Shift Keying (BPSK) modulation technique to uniquely discriminate surface lidar returns from intermediate aerosol and cloud returns. We demonstrate the utility of BPSK to eliminate sidelobes in the range profile as a means of making Integrated Path Differential Absorption (IPDA) column CO2 measurements in the presence of intervening optically thin clouds, thereby minimizing bias errors caused by the clouds. Furthermore, high accuracy and precision ranging to the Earth's surface as well as to the top of intermediate cloud layers, which is a requirement for the inversion of column CO2 number density measurements to column CO2 mixing ratios, has been demonstrated using new hyperfine interpolation techniques that takes advantage of the periodicity of the modulation waveforms. This approach works well for both BPSK and linear swept-frequency modulation techniques and provides very high (at sub-meter level) range resolution. The BPSK technique under investigation has excellent auto-correlation properties while possessing a finite bandwidth. A comparison of BPSK and linear swept-frequency is also discussed in this paper. These techniques are used in a new data processing architecture to support the ASCENDS CarbonHawk Experiment Simulator (ACES) and ACT-America programs.

  4. Advanced optical measurements for characterizing photophysical properties of single nanoparticles.

    SciTech Connect

    Polsky, Ronen; Davis, Ryan W.; Arango, Dulce C.; Brozik, Susan Marie; Wheeler, David Roger

    2009-09-01

    Formation of complex nanomaterials would ideally involve single-pot reaction conditions with one reactive site per nanoparticle, resulting in a high yield of incrementally modified or oriented structures. Many studies in nanoparticle functionalization have sought to generate highly uniform nanoparticles with tailorable surface chemistry necessary to produce such conjugates, with limited success. In order to overcome these limitations, we have modified commercially available nanoparticles with multiple potential reaction sites for conjugation with single ssDNAs, proteins, and small unilamellar vesicles. These approaches combined heterobifunctional and biochemical template chemistries with single molecule optical methods for improved control of nanomaterial functionalization. Several interesting analytical results have been achieved by leveraging techniques unique to SNL, and provide multiple paths for future improvements for multiplex nanoparticle synthesis and characterization. Hyperspectral imaging has proven especially useful for assaying substrate immobilized fluorescent particles. In dynamic environments, temporal correlation spectroscopies have been employed for tracking changes in diffusion/hydrodynamic radii, particle size distributions, and identifying mobile versus immobile sample fractions at unbounded dilution. Finally, Raman fingerprinting of biological conjugates has been enabled by resonant signal enhancement provided by intimate interactions with nanoparticles and composite nanoshells.

  5. A Relational Approach to Measuring Competition Among Hospitals

    PubMed Central

    Sohn, Min-Woong

    2002-01-01

    Objective To present a new, relational approach to measuring competition in hospital markets and to compare this relational approach with alternative methods of measuring competition. Data Sources The California Office of Statewide Health Planning and Development patient discharge abstracts and financial disclosure files for 1991. Study Design Patient discharge abstracts for an entire year were used to derive patient flows, which were combined to calculate the extent of overlap in patient pools for each pair of hospitals. This produces a cross-sectional measure of market competition among hospitals. Principal Findings The relational approach produces measures of competition between each and every pair of hospitals in the study sample, allowing us to examine a much more “local” as well as dyadic effect of competition. Preliminary analyses show the following: (1) Hospital markets are smaller than thought. (2) For-profit hospitals received considerably more competition from their neighbors than either nonprofit or government hospitals. (3) The size of a hospital does not matter in the amount of competition received, but the larger hospitals generated significantly more competition than smaller ones. Comparisons of this method to the other methods show considerable differences in identifying competitors, indicating that these methods are not as comparable as previously thought. Conclusion The relational approach measures competition in a more detailed way and allows researchers to conduct more fine-grained analyses of market competition. This approach allows one to model market structure in a manner that goes far beyond the traditional categories of monopoly, oligopoly, and perfect competition. It also opens up an entirely new range of analytic possibilities in examining the effect of competition on hospital performance, price of medical care, changes in the market, technology acquisition, and many other phenomena in the health care field. PMID:12036003

  6. Advances in Proteomics Data Analysis and Display Using an Accurate Mass and Time Tag Approach

    PubMed Central

    Zimmer, Jennifer S.D.; Monroe, Matthew E.; Qian, Wei-Jun; Smith, Richard D.

    2007-01-01

    Proteomics has recently demonstrated utility in understanding cellular processes on the molecular level as a component of systems biology approaches and for identifying potential biomarkers of various disease states. The large amount of data generated by utilizing high efficiency (e.g., chromatographic) separations coupled to high mass accuracy mass spectrometry for high-throughput proteomics analyses presents challenges related to data processing, analysis, and display. This review focuses on recent advances in nanoLC-FTICR-MS-based proteomics approaches and the accompanying data processing tools that have been developed to display and interpret the large volumes of data being produced. PMID:16429408

  7. An approach to measure wheelchair stability. Concept and benefits.

    PubMed

    Stefanov, Dimitar H; Pasco, Damien

    2014-01-01

    Wheelchair stability is dependent on user's body characteristics that can shift significantly the original center of mass in the cases of limb amputation, severe skeletal deformities or obesity. The center of gravity may change with the installation of additional devices such as oxygen cylinders or ventilators on the wheelchair. Therefore, quantitative evaluation and prediction of the behavior of the user-wheelchair system in a variety of static and dynamic situations is essential for user's safety and for the optimal tuning of the human-wheelchair system. In this paper we discuss an approach for wheelchair stability assessment that only requires two inclinations and weight measurements. We also discuss the algorithm associated to the procedure based on the use of the reaction forces in the contact points of the wheels measured by the load cells. Further, the paper includes an analysis of the influence of the errors in measurement of the input parameters on the output results and demonstrates that the proposed approach possesses high accuracy. The advantage of the proposed approach is the use of a reliable procedure based on three simple steps and five weight measurements with four independent load scales which may lead to the design of an affordable and accurate measurement system.

  8. DEVELOPMENT OF AN ADVANCED APPROACH FOR NEXT-GENERATION INTEGRATED RESERVOIR CHARACTERIZATION

    SciTech Connect

    Scott R. Reeves

    2005-04-01

    Accurate, high-resolution, three-dimensional (3D) reservoir characterization can provide substantial benefits for effective oilfield management. By doing so, the predictive reliability of reservoir flow models, which are routinely used as the basis for investment decisions involving hundreds of millions of dollars and designed to recover millions of barrels of oil, can be significantly improved. Even a small improvement in incremental recovery for high-value assets can result in important contributions to bottom-line profitability. Today's standard practice for developing a 3D reservoir description is to use seismic inversion techniques. These techniques make use of geostatistics and other stochastic methods to solve the inverse problem, i.e., to iteratively construct a likely geologic model and then upscale and compare its acoustic response to that actually observed in the field. This method has several inherent flaws, such as: (1) The resulting models are highly non-unique; multiple equiprobable realizations are produced, meaning (2) The results define a distribution of possible outcomes; the best they can do is quantify the uncertainty inherent in the modeling process, and (3) Each realization must be run through a flow simulator and history matched to assess it's appropriateness, and therefore (4) The method is labor intensive and requires significant time to complete a field study; thus it is applied to only a small percentage of oil and gas producing assets. A new approach to achieve this objective was first examined in a Department of Energy (DOE) study performed by Advanced Resources International (ARI) in 2000/2001. The goal of that study was to evaluate whether robust relationships between data at vastly different scales of measurement could be established using virtual intelligence (VI) methods. The proposed workflow required that three specific relationships be established through use of artificial neural networks (ANN's): core-to-log, log

  9. Summer Support of the Advanced Structures and Measurements Group

    NASA Technical Reports Server (NTRS)

    Stuber, Alexander Lee

    2010-01-01

    This presentation is my exit presentation summarizing the work that I did this summer during my 10 week summer internship. It is primarily focused on tensile testing of composite coupons including the use of the ARAMIS optical strain measurement system, but it also includes some discussion of other support that I provided for the Dryden composites working group effort. My main efforts in that area were focused on T-joint design for an upcoming hands-on-workshop as well as design of a fixture to test joint coupons. Finally, there is a brief discussion of the other small projects that I worked on, including support of structurally integrated thermal protection system (STIPS) research and the Global Observer wing loads test.

  10. Severe accident approach - final report. Evaluation of design measures for severe accident prevention and consequence mitigation.

    SciTech Connect

    Tentner, A. M.; Parma, E.; Wei, T.; Wigeland, R.; Nuclear Engineering Division; SNL; INL

    2010-03-01

    An important goal of the US DOE reactor development program is to conceptualize advanced safety design features for a demonstration Sodium Fast Reactor (SFR). The treatment of severe accidents is one of the key safety issues in the design approach for advanced SFR systems. It is necessary to develop an in-depth understanding of the risk of severe accidents for the SFR so that appropriate risk management measures can be implemented early in the design process. This report presents the results of a review of the SFR features and phenomena that directly influence the sequence of events during a postulated severe accident. The report identifies the safety features used or proposed for various SFR designs in the US and worldwide for the prevention and/or mitigation of Core Disruptive Accidents (CDA). The report provides an overview of the current SFR safety approaches and the role of severe accidents. Mutual understanding of these design features and safety approaches is necessary for future collaborations between the US and its international partners as part of the GEN IV program. The report also reviews the basis for an integrated safety approach to severe accidents for the SFR that reflects the safety design knowledge gained in the US during the Advanced Liquid Metal Reactor (ALMR) and Integral Fast Reactor (IFR) programs. This approach relies on inherent reactor and plant safety performance characteristics to provide additional safety margins. The goal of this approach is to prevent development of severe accident conditions, even in the event of initiators with safety system failures previously recognized to lead directly to reactor damage.

  11. Advanced Precipitation Radar Antenna to Measure Rainfall From Space

    NASA Technical Reports Server (NTRS)

    Rahmat-Samii, Yahya; Lin, John; Huang, John; Im, Eastwood; Lou, Michael; Lopez, Bernardo; Durden, Stephen

    2008-01-01

    To support NASA s planned 20-year mission to provide sustained global precipitation measurement (EOS-9 Global Precipitation Measurement (GPM)), a deployable antenna has been explored with an inflatable thin-membrane structure. This design uses a 5.3 5.3-m inflatable parabolic reflector with the electronically scanned, dual-frequency phased array feeds to provide improved rainfall measurements at 2.0-km horizontal resolution over a cross-track scan range of up to 37 , necessary for resolving intense, isolated storm cells and for reducing the beam-filling and spatial sampling errors. The two matched radar beams at the two frequencies (Ku and Ka bands) will allow unambiguous retrieval of the parameters in raindrop size distribution. The antenna is inflatable, using rigidizable booms, deployable chain-link supports with prescribed curvatures, a smooth, thin-membrane reflecting surface, and an offset feed technique to achieve the precision surface tolerance (0.2 mm RMS) for meeting the low-sidelobe requirement. The cylindrical parabolic offset-feed reflector augmented with two linear phased array feeds achieves dual-frequency shared-aperture with wide-angle beam scanning and very low sidelobe level of -30 dB. Very long Ku and Ka band microstrip feed arrays incorporating a combination of parallel and series power divider lines with cosine-over-pedestal distribution also augment the sidelobe level and beam scan. This design reduces antenna mass and launch vehicle stowage volume. The Ku and Ka band feed arrays are needed to achieve the required cross-track beam scanning. To demonstrate the inflatable cylindrical reflector with two linear polarizations (V and H), and two beam directions (0deg and 30deg), each frequency band has four individual microstrip array designs. The Ku-band array has a total of 166x2 elements and the Ka-band has 166x4 elements with both bands having element spacing about 0.65 lambda(sub 0). The cylindrical reflector with offset linear array feeds

  12. AN ADVANCED CALIBRATION PROCEDURE FOR COMPLEX IMPEDANCE SPECTRUM MEASUREMENTS OF ADVANCED ENERGY STORAGE DEVICES

    SciTech Connect

    William H. Morrison; Jon P. Christophersen; Patrick Bald; John L. Morrison

    2012-06-01

    With the increasing demand for electric and hybrid electric vehicles and the explosion in popularity of mobile and portable electronic devices such as laptops, cell phones, e-readers, tablet computers and the like, reliance on portable energy storage devices such as batteries has likewise increased. The concern for the availability of critical systems in turn drives the availability of battery systems and thus the need for accurate battery health monitoring has become paramount. Over the past decade the Idaho National Laboratory (INL), Montana Tech of the University of Montana (Tech), and Qualtech Systems, Inc. (QSI) have been developing the Smart Battery Status Monitor (SBSM), an integrated battery management system designed to monitor battery health, performance and degradation and use this knowledge for effective battery management and increased battery life. Key to the success of the SBSM is an in-situ impedance measurement system called the Impedance Measurement Box (IMB). One of the challenges encountered has been development of an accurate, simple, robust calibration process. This paper discusses the successful realization of this process.

  13. The JRC-ITU approach to the safety of advanced nuclear fuel cycles

    SciTech Connect

    Fanghaenel, T.; Rondinella, V.V.; Somers, J.; Konings, R.; Erdmann, N.; Uffelen, P. van; Glatz, J.P.

    2013-07-01

    The JRC-ITU safety studies of advanced fuels and cycles adopt two main axes. First the full exploitation of still available and highly relevant knowledge and samples from past fuel preparation and irradiation campaigns (complementing the limited number of ongoing programmes). Secondly, the shift of focus from simple property measurement towards the understanding of basic mechanisms determining property evolution and behaviour of fuel compounds during normal, off-normal and accident conditions. The final objective of the second axis is the determination of predictive tools applicable to systems and conditions different from those from which they were derived. State of the art experimental facilities, extensive networks of partnerships and collaboration with other organizations worldwide, and a developing programme for training and education are essential in this approach. This strategy has been implemented through various programs and projects. The SUPERFACT programme constitutes the main body of existing knowledge on the behavior in-pile of MOX fuel containing minor actinides. It encompassed all steps of a closed fuel cycle. Another international project investigating the safety of a closed cycle is METAPHIX. In this case a U-Pu19-Zr10 metal alloy containing Np, Am and Cm constitutes the fuel. 9 test pins have been prepared and irradiated. In addition to the PIE (Post Irradiation Examination), pyrometallurgical separation of the irradiated fuel has been performed, to demonstrate all the steps of a multiple recycling closed cycle and characterize their safety relevant aspects. Basic studies like thermodynamic fuel properties, fuel-cladding-coolant interactions have also been carried out at JRC-ITU.

  14. Advanced Measurement and Modeling Techniques for Improved SOFC Cathodes

    SciTech Connect

    Stuart Adler; L. Dunyushkina; S. Huff; Y. Lu; J. Wilson

    2006-12-31

    The goal of this project was to develop an improved understanding of factors governing performance and degradation of mixed-conducting SOFC cathodes. Two new diagnostic tools were developed to help achieve this goal: (1) microelectrode half-cells for improved isolation of cathode impedance on thin electrolytes, and (2) nonlinear electrochemical impedance spectroscopy (NLEIS), a variant of traditional impedance that allows workers to probe nonlinear rates as a function of frequency. After reporting on the development and efficacy of these tools, this document reports on the use of these and other tools to better understand performance and degradation of cathodes based on the mixed conductor La{sub 1-x}Sr{sub x}CoO{sub 3-{delta}} (LSC) on gadolinia or samaria-doped ceria (GDC or SDC). We describe the use of NLEIS to measure O{sub 2} exchange on thin-film LSC electrodes, and show that O{sub 2} exchange is most likely governed by dissociative adsorption. We also describe parametric studies of porous LSC electrodes using impedance and NLEIS. Our results suggest that O{sub 2} exchange and ion transport co-limit performance under most relevant conditions, but it is O{sub 2} exchange that is most sensitive to processing, and subject to the greatest degradation and sample-to-sample variation. We recommend further work that focuses on electrodes of well-defined or characterized geometry, and probes the details of surface structure, composition, and impurities. Parallel work on primarily electronic conductors (LSM) would also be of benefit to developers, and to improved understanding of surface vs. bulk diffusion.

  15. Measuring neuronal branching patterns using model-based approach.

    PubMed

    Luczak, Artur

    2010-01-01

    Neurons have complex branching systems which allow them to communicate with thousands of other neurons. Thus understanding neuronal geometry is clearly important for determining connectivity within the network and how this shapes neuronal function. One of the difficulties in uncovering relationships between neuronal shape and its function is the problem of quantifying complex neuronal geometry. Even by using multiple measures such as: dendritic length, distribution of segments, direction of branches, etc, a description of three dimensional neuronal embedding remains incomplete. To help alleviate this problem, here we propose a new measure, a shape diffusiveness index (SDI), to quantify spatial relations between branches at the local and global scale. It was shown that growth of neuronal trees can be modeled by using diffusion limited aggregation (DLA) process. By measuring "how easy" it is to reproduce the analyzed shape by using the DLA algorithm it can be measured how "diffusive" is that shape. Intuitively, "diffusiveness" measures how tree-like is a given shape. For example shapes like an oak tree will have high values of SDI. This measure is capturing an important feature of dendritic tree geometry, which is difficult to assess with other measures. This approach also presents a paradigm shift from well-defined deterministic measures to model-based measures, which estimate how well a model with specific properties can account for features of analyzed shape. PMID:21079752

  16. High-throughput and quantitative approaches for measuring circadian rhythms in cyanobacteria using bioluminescence.

    PubMed

    Shultzaberger, Ryan K; Paddock, Mark L; Katsuki, Takeo; Greenspan, Ralph J; Golden, Susan S

    2015-01-01

    The temporal measurement of a bioluminescent reporter has proven to be one of the most powerful tools for characterizing circadian rhythms in the cyanobacterium Synechococcus elongatus. Primarily, two approaches have been used to automate this process: (1) detection of cell culture bioluminescence in 96-well plates by a photomultiplier tube-based plate-cycling luminometer (TopCount Microplate Scintillation and Luminescence Counter, Perkin Elmer) and (2) detection of individual colony bioluminescence by iteratively rotating a Petri dish under a cooled CCD camera using a computer-controlled turntable. Each approach has distinct advantages. The TopCount provides a more quantitative measurement of bioluminescence, enabling the direct comparison of clock output levels among strains. The computer-controlled turntable approach has a shorter set-up time and greater throughput, making it a more powerful phenotypic screening tool. While the latter approach is extremely useful, only a few labs have been able to build such an apparatus because of technical hurdles involved in coordinating and controlling both the camera and the turntable, and in processing the resulting images. This protocol provides instructions on how to construct, use, and process data from a computer-controlled turntable to measure the temporal changes in bioluminescence of individual cyanobacterial colonies. Furthermore, we describe how to prepare samples for use with the TopCount to minimize experimental noise and generate meaningful quantitative measurements of clock output levels for advanced analysis. PMID:25662451

  17. High-throughput and quantitative approaches for measuring circadian rhythms in cyanobacteria using bioluminescence.

    PubMed

    Shultzaberger, Ryan K; Paddock, Mark L; Katsuki, Takeo; Greenspan, Ralph J; Golden, Susan S

    2015-01-01

    The temporal measurement of a bioluminescent reporter has proven to be one of the most powerful tools for characterizing circadian rhythms in the cyanobacterium Synechococcus elongatus. Primarily, two approaches have been used to automate this process: (1) detection of cell culture bioluminescence in 96-well plates by a photomultiplier tube-based plate-cycling luminometer (TopCount Microplate Scintillation and Luminescence Counter, Perkin Elmer) and (2) detection of individual colony bioluminescence by iteratively rotating a Petri dish under a cooled CCD camera using a computer-controlled turntable. Each approach has distinct advantages. The TopCount provides a more quantitative measurement of bioluminescence, enabling the direct comparison of clock output levels among strains. The computer-controlled turntable approach has a shorter set-up time and greater throughput, making it a more powerful phenotypic screening tool. While the latter approach is extremely useful, only a few labs have been able to build such an apparatus because of technical hurdles involved in coordinating and controlling both the camera and the turntable, and in processing the resulting images. This protocol provides instructions on how to construct, use, and process data from a computer-controlled turntable to measure the temporal changes in bioluminescence of individual cyanobacterial colonies. Furthermore, we describe how to prepare samples for use with the TopCount to minimize experimental noise and generate meaningful quantitative measurements of clock output levels for advanced analysis.

  18. High throughput and quantitative approaches for measuring circadian rhythms in cyanobacteria using bioluminescence

    PubMed Central

    Shultzaberger, Ryan K.; Paddock, Mark L.; Katsuki, Takeo; Greenspan, Ralph J.; Golden, Susan S.

    2016-01-01

    The temporal measurement of a bioluminescent reporter has proven to be one of the most powerful tools for characterizing circadian rhythms in the cyanobacterium Synechococcus elongatus. Primarily, two approaches have been used to automate this process: (1) detection of cell culture bioluminescence in 96-well plates by a photomultiplier tube-based plate-cycling luminometer (TopCount Microplate Scintillation and Luminescence Counter, Perkin Elmer) and (2) detection of individual colony bioluminescence by iteratively rotating a Petri dish under a cooled CCD camera using a computer-controlled turntable. Each approach has distinct advantages. The TopCount provides a more quantitative measurement of bioluminescence, enabling the direct comparison of clock output levels among strains. The computer-controlled turntable approach has a shorter set-up time and greater throughput, making it a more powerful phenotypic screening tool. While the latter approach is extremely useful, only a few labs have been able to build such an apparatus because of technical hurdles involved in coordinating and controlling both the camera and the turntable, and in processing the resulting images. This protocol provides instructions on how to construct, use, and process data from a computer-controlled turntable to measure the temporal changes in bioluminescence of individual cyanobacterial colonies. Furthermore, we describe how to prepare samples for use with the TopCount to minimize experimental noise, and generate meaningful quantitative measurements of clock output levels for advanced analysis. PMID:25662451

  19. A non-Gaussian approach to risk measures

    NASA Astrophysics Data System (ADS)

    Bormetti, Giacomo; Cisana, Enrica; Montagna, Guido; Nicrosini, Oreste

    2007-03-01

    Reliable calculations of financial risk require that the fat-tailed nature of prices changes is included in risk measures. To this end, a non-Gaussian approach to financial risk management is presented, modelling the power-law tails of the returns distribution in terms of a Student- t distribution. Non-Gaussian closed-form solutions for value-at-risk and expected shortfall are obtained and standard formulae known in the literature under the normality assumption are recovered as a special case. The implications of the approach for risk management are demonstrated through an empirical analysis of financial time series from the Italian stock market and in comparison with the results of the most widely used procedures of quantitative finance. Particular attention is paid to quantify the size of the errors affecting the market risk measures obtained according to different methodologies, by employing a bootstrap technique.

  20. Measuring and monitoring IT using a balanced scorecard approach.

    PubMed

    Gash, Deborah J; Hatton, Todd

    2007-01-01

    Ensuring that the information technology department is aligned with the overall health system strategy and is performing at a consistently high level is a priority at Saint Luke's Health System in Kansas City, Mo. The information technology department of Saint Luke's Health System has been using the balanced scorecard approach described in this article to measure and monitor its performance for four years. This article will review the structure of the IT department's scorecard; the categories and measures used; how benchmarks are determined; how linkage to the organizational scorecard is made; how results are reported; how changes are made to the scorecard; and tips for using a scorecard in other IT departments.

  1. Measurement and modeling of advanced coal conversion processes. Annual report, October 1990--September 1991

    SciTech Connect

    Solomon, P.R.; Serio, M.A.; Hamblen, D.G.; Smoot, L.D.; Brewster, B.S. |

    1991-12-31

    The overall objective of this program is the development of predictive capability for the design, scale up, simulation, control and feedstock evaluation in advanced coal conversion devices. This program will merge significant advances made in measuring and quantitatively describing the mechanisms in coal conversion behavior. Comprehensive computer codes for mechanistic modeling of entrained-bed gasification. Additional capabilities in predicting pollutant formation will be implemented and the technology will be expanded to fixed-bed reactors.

  2. Comparison of a Traditional Probabilistic Risk Assessment Approach with Advanced Safety Analysis

    SciTech Connect

    Smith, Curtis L; Mandelli, Diego; Zhegang Ma

    2014-11-01

    As part of the Light Water Sustainability Program (LWRS) [1], the purpose of the Risk Informed Safety Margin Characterization (RISMC) [2] Pathway research and development (R&D) is to support plant decisions for risk-informed margin management with the aim to improve economics, reliability, and sustain safety of current NPPs. In this paper, we describe the RISMC analysis process illustrating how mechanistic and probabilistic approaches are combined in order to estimate a safety margin. We use the scenario of a “station blackout” (SBO) wherein offsite power and onsite power is lost, thereby causing a challenge to plant safety systems. We describe the RISMC approach, illustrate the station blackout modeling, and contrast this with traditional risk analysis modeling for this type of accident scenario. We also describe our approach we are using to represent advanced flooding analysis.

  3. Approach to the measurement of astronomical mirrors with new procedures

    NASA Astrophysics Data System (ADS)

    Hofbauer, E.; Rascher, R.; Stubenrauch, Th.; Liebl, J.; Maurer, R.; Zimmermann, A.; Rösch, O.; Reitberger, J.

    2013-04-01

    The manufacturing of optical components more often requires grinding and polishing of non rotational symmetric aspheres or freeform surfaces. Although there are measurement techniques available for small diameters of some 10th of mm the measuring of larger surfaces is not or only by extreme efforts feasible. Based on the specification for a large mirror in semi professional and scientific astronomy with up to 1.2 m diameter and a relative aperture of F# < 1.5 a final measurement approach for the measurement of radius and shape deviation (parameters of code number 3 of DIN ISO 10110) is described. The combination and evaluation of different sensors and measurement methods for the measurement of high-precision optical surfaces with concave radii of 3.000 mm to infinity is examined and presented. A reproducibility and absolute accuracy of better l/12 (PV) and l/40 (rms) is to be achieved. The absolute maximum radius difference should be smaller than 0,1 %. Thus, also the measurement of aspheric surfaces and free-form surfaces are investigated. For the measurement of large surfaces, up to 100 individual sub apertures with up to 100 Million Points are recorded by deflectometric or interferometric measurement techniques and composed algorithmically to a total surface area. A precision granite portal with multifunctional device carrier will be presented as precise movements are crucial for all tests. The realization of the required accuracy in the portal-measurement device is verified, documented and compared with a simulation. Results on specimens of 200 and 430 mm diameter are evaluated. The measurements were taken by deflectometry and interferometry on the described test equipment. The validation of the samples with various interferometric procedures was performed. The obtained results are presented, analyzed and discussed.

  4. Advanced Ultrasonic Measurement Methodology for Non-Invasive Interrogation and Identification of Fluids in Sealed Containers

    SciTech Connect

    Tucker, Brian J.; Diaz, Aaron A.; Eckenrode, Brian A.

    2006-03-16

    The Hazardous Materials Response Unit (HMRU) and the Counterterrorism and Forensic Science Research Unit (CTFSRU), Laboratory Division, Federal Bureau of Investigation (FBI) have been mandated to develop and establish a wide range of unprecedented capabilities for providing scientific and technical forensic services to investigations involving hazardous chemical, biological, and radiological materials, including extremely dangerous chemical and biological warfare agents. Pacific Northwest National Laboratory (PNNL) has developed a portable, hand-held, hazardous materials acoustic inspection device (HAZAID) that provides noninvasive container interrogation and material identification capabilities using nondestructive ultrasonic velocity and attenuation measurements. Due to the wide variety of fluids as well as container sizes and materials, the need for high measurement sensitivity and advanced ultrasonic measurement techniques were identified. The HAZAID prototype was developed using a versatile electronics platform, advanced ultrasonic wave propagation methods, and advanced signal processing techniques. This paper primarily focuses on the ultrasonic measurement methods and signal processing techniques incorporated into the HAZAID prototype. High bandwidth ultrasonic transducers combined with the advanced pulse compression technique allowed researchers to 1) impart large amounts of energy, 2) obtain high signal-to-noise ratios, and 3) obtain accurate and consistent time-of-flight (TOF) measurements through a variety of highly attenuative containers and fluid media. Results of this feasibility study demonstrated that the HAZAID experimental measurement technique also provided information regarding container properties, which will be utilized in future container-independent measurements of hidden liquids.

  5. Advanced ultrasonic measurement methodology for non-invasive interrogation and identification of fluids in sealed containers

    NASA Astrophysics Data System (ADS)

    Tucker, Brian J.; Diaz, Aaron A.; Eckenrode, Brian A.

    2006-03-01

    Government agencies and homeland security related organizations have identified the need to develop and establish a wide range of unprecedented capabilities for providing scientific and technical forensic services to investigations involving hazardous chemical, biological, and radiological materials, including extremely dangerous chemical and biological warfare agents. Pacific Northwest National Laboratory (PNNL) has developed a prototype portable, hand-held, hazardous materials acoustic inspection prototype that provides noninvasive container interrogation and material identification capabilities using nondestructive ultrasonic velocity and attenuation measurements. Due to the wide variety of fluids as well as container sizes and materials encountered in various law enforcement inspection activities, the need for high measurement sensitivity and advanced ultrasonic measurement techniques were identified. The prototype was developed using a versatile electronics platform, advanced ultrasonic wave propagation methods, and advanced signal processing techniques. This paper primarily focuses on the ultrasonic measurement methods and signal processing techniques incorporated into the prototype. High bandwidth ultrasonic transducers combined with an advanced pulse compression technique allowed researchers to 1) obtain high signal-to-noise ratios and 2) obtain accurate and consistent time-of-flight (TOF) measurements through a variety of highly attenuative containers and fluid media. Results of work conducted in the laboratory have demonstrated that the prototype experimental measurement technique also provided information regarding container properties, which will be utilized in future container-independent measurements of hidden liquids.

  6. Advanced ultrasonic measurement methodology for non-invasive interrogation and identification of fluids in sealed containers

    SciTech Connect

    Tucker, Brian J.; Diaz, Aaron A.; Eckenrode, Brian A.

    2006-05-01

    Government agencies and homeland security related organizations have identified the need to develop and establish a wide range of unprecedented capabilities for providing scientific and technical forensic services to investigations involving hazardous chemical, biological, and radiological materials, including extremely dangerous chemical and biological warfare agents. Pacific Northwest National Laboratory (PNNL) has developed a prototype portable, hand-held, hazardous materials acoustic inspection prototype that provides noninvasive container interrogation and material identification capabilities using nondestructive ultrasonic velocity and attenuation measurements. Due to the wide variety of fluids as well as container sizes and materials encountered in various law enforcement inspection activities, the need for high measurement sensitivity and advanced ultrasonic measurement techniques were identified. The prototype was developed using a versatile electronics platform, advanced ultrasonic wave propagation methods, and advanced signal processing techniques. This paper primarily focuses on the ultrasonic measurement methods and signal processing techniques incorporated into the prototype. High bandwidth ultrasonic transducers combined with an advanced pulse compression technique allowed researchers to 1) obtain high signal-to-noise ratios and 2) obtain accurate and consistent time-of-flight (TOF) measurements through a variety of highly attenuative containers and fluid media. Results of work conducted in the laboratory have demonstrated that the prototype experimental measurement technique also provided information regarding container properties, which will be utilized in future container-independent measurements of hidden liquids.

  7. Digital approach for measuring dentin translucency in forensic age estimation

    PubMed Central

    Singh, Simranjit; Venkatapathy, Ramesh; Balamurali, PD; Charles, NSC; Suganya, R

    2013-01-01

    Background: Dentin translucency is best suited for age estimation not only in terms of accuracy but also in terms of simplicity. Conventionally, translucency has been measured using calipers. Computer-based methods have been proposed for the same, although these required the use of custom-built software programs. Objectives: The objectives of the study were to use a simple digital method to measure dentinal translucency on sectioned teeth and to compare digital measurements to conventionally obtained translucency measurements. Materials and Methods: Fifty extracted permanent teeth were collected and were sectioned to 250 μm. Translucency measurements were obtained using the digital method and compared with those obtained using a caliper. Results: Correlation coefficients of translucency measurements to age were statistically significant for both methods (P < 0.001), and marginally higher for the conventional approach (r = 0.4671). Application of derived linear regression equations on an independent sample (n = 10) revealed a similar ability of both the methods to assess age to within ±5 years of the actual age. Conclusion: The translucency measurements obtained by the two methods were very similar, with no clear superiority of one method over the other. Hence, further studies on a large scale are warranted to determine which method is more reliable to estimate the age. PMID:23960415

  8. Application of the LBB regulatory approach to the steamlines of advanced WWER 1000 reactor

    SciTech Connect

    Kiselyov, V.A.; Sokov, L.M.

    1997-04-01

    The LBB regulatory approach adopted in Russia in 1993 as an extra safety barrier is described for advanced WWER 1000 reactor steamline. The application of LBB concept requires the following additional protections. First, the steamline should be a highly qualified piping, performed in accordance with the applicable regulations and guidelines, carefully screened to verify that it is not subjected to any disqualifying failure mechanism. Second, a deterministic fracture mechanics analysis and leak rate evaluation have been performed to demonstrate that postulated through-wall crack that yields 95 1/min at normal operation conditions is stable even under seismic loads. Finally, it has been verified that the leak detection systems are sufficiently reliable, diverse and sensitive, and that adequate margins exist to detect a through wall crack smaller than the critical size. The obtained results are encouraging and show the possibility of the application of the LBB case to the steamline of advanced WWER 1000 reactor.

  9. Spatial regression with covariate measurement error: A semi-parametric approach

    PubMed Central

    Huque, Md Hamidul; Bondell, Howard D.; Carroll, Raymond J.; Ryan, Louise M.

    2015-01-01

    Summary Spatial data have become increasingly common in epidemiology and public health research thanks to advances in GIS (Geographic Information Systems) technology. In health research, for example, it is common for epidemiologists to incorporate geographically indexed data into their studies. In practice, however, the spatially-defined covariates are often measured with error. Naive estimators of regression coefficients are attenuated if measurement error is ignored. Moreover, the classical measurement error theory is inapplicable in the context of spatial modelling because of the presence of spatial correlation among the observations. We propose a semi-parametric regression approach to obtain bias corrected estimates of regression parameters and derive their large sample properties. We evaluate the performance of the proposed method through simulation studies and illustrate using data on Ischemic Heart Disease (IHD). Both simulation and practical application demonstrate that the proposed method can be effective in practice. PMID:26788930

  10. M-health medical video communication systems: an overview of design approaches and recent advances.

    PubMed

    Panayides, A S; Pattichis, M S; Constantinides, A G; Pattichis, C S

    2013-01-01

    The emergence of the new, High Efficiency Video Coding (HEVC) standard, combined with wide deployment of 4G wireless networks, will provide significant support toward the adoption of mobile-health (m-health) medical video communication systems in standard clinical practice. For the first time since the emergence of m-health systems and services, medical video communication systems can be deployed that can rival the standards of in-hospital examinations. In this paper, we provide a thorough overview of today's advancements in the field, discuss existing approaches, and highlight the future trends and objectives.

  11. Cell therapy, advanced materials, and new approaches to acute kidney injury.

    PubMed

    Yevzlin, Alexander S; Humes, H David

    2009-12-01

    Acute renal failure (ARF) is a common clinical syndrome characterized by an abrupt deterioration in kidney function, resulting in abnormalities in volume-regulatory, metabolic-regulatory, excretory, and endocrine functions. Despite decades of improvements in the provision of intensive care, and specifically in the provision of renal replacement therapy, the morbidity and mortality associated with acute kidney injury (AKI) remain extremely high. This article highlights novel cell therapies, advanced materials, and approaches to AKI with the aim of illuminating a potential path for future basic, translational, and clinical research using these novel modalities.

  12. Experimental measurements of motion cue effects on STOL approach tasks

    NASA Technical Reports Server (NTRS)

    Ringland, R. F.; Stapleford, R. L.

    1972-01-01

    An experimental program to investigate the effects of motion cues on STOL approach is presented. The simulator used was the Six-Degrees-of-Freedom Motion Simulator (S.01) at Ames Research Center of NASA which has ?2.7 m travel longitudinally and laterally and ?2.5 m travel vertically. Three major experiments, characterized as tracking tasks, were conducted under fixed and moving base conditions: (1) A simulated IFR approach of the Augmentor Wing Jet STOL Research Aircraft (AWJSRA), (2) a simulated VFR task with the same aircraft, and (3) a single-axis task having only linear acceleration as the motion cue. Tracking performance was measured in terms of the variances of several motion variables, pilot vehicle describing functions, and pilot commentary.

  13. An intuitive approach to measuring protein surface curvature.

    PubMed

    Coleman, Ryan G; Burr, Michael A; Souvaine, Diane L; Cheng, Alan C

    2005-12-01

    A natural way to measure protein surface curvature is to generate the least squares fitted (LSF) sphere to a surface patch and use the radius as the curvature measure. While the concept is simple, the sphere-fitting problem is not trivial and known means of protein surface curvature measurement use alternative schemes that are arguably less straightforward to interpret. We have developed an approach to solve the LSF sphere problem by turning the sphere-fitting problem into a solvable plane-fitting problem using a transformation known as geometric inversion. The approach works on any arbitrary surface patch, and returns a radius of curvature that has direct physical interpretation. Additionally, it is flexible in its ability to find the curvature of an arbitrary surface patch, and the "resolution" can be adjusted to highlight atomic features or larger features such as peptide binding sites. We include examples of applying the method to visualization of peptide recognition pockets and protein conformational change, as well as a comparison with a commonly used solid-angle curvature method showing that the LSF method produces more pronounced curvature results.

  14. An Algebraic Approach to Unital Quantities and their Measurement

    NASA Astrophysics Data System (ADS)

    Domotor, Zoltan; Batitsky, Vadim

    2016-06-01

    The goals of this paper fall into two closely related areas. First, we develop a formal framework for deterministic unital quantities in which measurement unitization is understood to be a built-in feature of quantities rather than a mere annotation of their numerical values with convenient units. We introduce this idea within the setting of certain ordered semigroups of physical-geometric states of classical physical systems. States are assumed to serve as truth makers of metrological statements about quantity values. A unital quantity is presented as an isomorphism from the target system's ordered semigroup of states to that of positive reals. This framework allows us to include various derived and variable quantities, encountered in engineering and the natural sciences. For illustration and ease of presentation, we use the classical notions of length, time, electric current and mean velocity as primordial examples. The most important application of the resulting unital quantity calculus is in dimensional analysis. Second, in evaluating measurement uncertainty due to the analog-to-digital conversion of the measured quantity's value into its measuring instrument's pointer quantity value, we employ an ordered semigroup framework of pointer states. Pointer states encode the measuring instrument's indiscernibility relation, manifested by not being able to distinguish the measured system's topologically proximal states. Once again, we focus mainly on the measurement of length and electric current quantities as our motivating examples. Our approach to quantities and their measurement is strictly state-based and algebraic in flavor, rather than that of a representationalist-style structure-preserving numerical assignment.

  15. Measurement issues in assessing employee performance: A generalizability theory approach

    SciTech Connect

    Stephenson, B.O.

    1996-08-01

    Increasingly, organizations are assessing employee performance through the use of rating instruments employed in the context of varied data collection strategies. For example, the focus may be on obtaining multiple perspectives regarding employee performance (360{degree} evaluation). From the standpoint of evaluating managers, upward assessments and ``peer to peer`` evaluations are perhaps two of the more common examples of such a multiple perspective approach. Unfortunately, it is probably fair to say that the increased interest and use of such data collection strategies has not been accompanied by a corresponding interest in addressing both validity and reliability concerns that have traditionally been associated with other forms of employee assessment (e.g., testing, assessment centers, structured interviews). As a consequence, many organizations may be basing decisions upon information collected under less than ideal measurement conditions. To the extent that such conditions produce unreliable measurements, the process may be both dysfunctional to the organization and/or unfair to the individual(s) being evaluated. Conversely, the establishment of reliable and valid measurement processes may in itself support the utilization of results in pursuit of organizational goals and enhance the credibility of the measurement process (see McEvoy (1990), who found the acceptance of subordinate ratings to be related to perceived accuracy and fairness of the measurement process). The present paper discusses a recent ``peer to peer`` evaluation conducted in our organization. The intent is to focus on the design of the study and present a Generalizability Theory (GT) approach to assessing the overall quality of the data collection strategy, along with suggestions for improving future designs. 9 refs., 3 tabs.

  16. A Young measure approach to nonlinear membrane theory

    NASA Astrophysics Data System (ADS)

    Bocea, Marian

    A new approach to study the asymptotic behavior of minimizing sequences arising in Nonlinear Membrane Theory is proposed by means of Young measures. Nonlinear 3D-2D dimensional reduction rests on the mastery of sequences {( 1au3| 1313u3 )} of scaled gradients bounded in Lp(O; M3x3 ), 1 < p < +infinity. In the first part of the thesis it is shown that, up to a subsequence, u3 may be decomposed as w3+z3 , where z3 carries all the concentration effects, i.e. {|( 1aw3| 1313w3 )|p} is equi-integrable, and w3 captures the oscillatory behavior, i.e. z3 → 0 in measure. As a first consequence, p-equi-integrable minimizing sequences energetically preferring thinner and thinner reference domains are shown to exist for the Dirichlet problem on an arbitrarily large cylinder, and under affine lateral boundary conditions. Moreover, p-equi-integrable recovery sequences that are independent on the transverse variable nearby ∂O are constructed. In the last two parts of the thesis, integral representation results for relaxed functionals arising in the derivation of nonlinear membrane models are obtained in terms of particular classes of Young measures. A complete description (in the spirit of Kinderlehrer and Pedregal's characterization of W1,p-gradient Young measures) is provided for the class of bending Young measures.

  17. Advances in Domain Connectivity for Overset Grids Using the X-Rays Approach

    NASA Technical Reports Server (NTRS)

    Chan, William M.; Kim, Noah; Pandya, Shishir A.

    2012-01-01

    Advances in automation and robustness of the X-rays approach to domain connectivity for overset grids are presented. Given the surface definition for each component that makes up a complex configuration, the determination of hole points with appropriate hole boundaries is automatically and efficiently performed. Improvements made to the original X-rays approach for identifying the minimum hole include an automated closure scheme for hole-cutters with open boundaries, automatic determination of grid points to be considered for blanking by each hole-cutter, and an adaptive X-ray map to economically handle components in close proximity. Furthermore, an automated spatially varying offset of the hole boundary from the minimum hole is achieved using a dual wall-distance function and an orphan point removal iteration process. Results using the new scheme are presented for a number of static and relative motion test cases on a variety of aerospace applications.

  18. An Ontological-Fuzzy Approach to Advance Reservation in Multi-Cluster Grids

    NASA Astrophysics Data System (ADS)

    Ferreira, D. J.; Dantas, M. A. R.; Bauer, Michael A.

    2010-11-01

    Advance reservation is an important mechanism for a successful utilization of available resources in distributed multi-cluster environments. This mechanism allows, for example, a user to provide parameters aiming to satisfy requirements related to applications' execution time and temporal dependence. This predictability can lead the system to reach higher levels of QoS. However, the support for advance reservation has been restricted due to the complexity of large scale configurations and also dynamic changes verified in these systems. In this research work it is proposed an advance reservation method, based on a ontology-fuzzy approach. It allows a user to reserve a wide variety of resources and enable large jobs to be reserved among different nodes. In addition, it dynamically verifies the possibility of reservation with the local RMS, avoiding future allocation conflicts. Experimental results of the proposal, through simulation, indicate that the proposed mechanism reached a successful level of flexibility for large jobs and more appropriated distribution of resources in a distributed multi-cluster configuration.

  19. EDITORIAL: Advances in Measurement Technology and Intelligent Instruments for Production Engineering

    NASA Astrophysics Data System (ADS)

    Gao, Wei; Takaya, Yasuhiro; Gao, Yongsheng; Krystek, Michael

    2008-08-01

    the other papers, two are related to length measurement, which forms the basis of dimensional measurement. Schödel et al from Physikalisch Technische Bundesanstalt (PTB) describe the recent state of thermal expansion measurements with PTB's Precision Interferometer, which are based on the observation of the absolute length of samples by using phase stepping interferometry. Meiners-Hagen et al, also from PTB, investigate an improved method for compensation of the refractive index of air in length measurements by optical interferometry where the air pressure and the humidity are measured. Three papers concern surface metrology. Song et al from NIST (National Institutes of Standards and Technology) report topography measurement for determining the decay factors in surface replication of Standard Casing to support ballistics measurements in the US. Takahashi et al from the University of Tokyo present a lateral resolution improvement for a total internal reflection fluorescence microscope that employs the combined use of standing evanescent light and a scattering distribution retrieval algorithm with successive approximation. X Liu et al from Warwick University report on a new investigation into how surface topography and friction affect the touch-feel perception, with the results showing that both the measured roughness and friction coefficient have a strong correlation with rough-smooth and grippy-slippery feelings. Measurement algorithms and calibration are described in the following three papers. Hessling from SP Technical Research Institute of Sweden presents a general unprecedented framework for dynamic evaluation of measurement systems, which separates physical experiments, analysis and signal processing methods into succeeding steps of evaluations. Wübbeler et al from PTB illustrate the Monte Carlo method required for the numerical calculations of the probability density function approach, which has been proposed for evaluation of measurement uncertainty

  20. A Coupled Approach for Structural Damage Detection with Incomplete Measurements

    NASA Technical Reports Server (NTRS)

    James, George; Cao, Timothy; Kaouk, Mo; Zimmerman, David

    2013-01-01

    This historical work couples model order reduction, damage detection, dynamic residual/mode shape expansion, and damage extent estimation to overcome the incomplete measurements problem by using an appropriate undamaged structural model. A contribution of this work is the development of a process to estimate the full dynamic residuals using the columns of a spring connectivity matrix obtained by disassembling the structural stiffness matrix. Another contribution is the extension of an eigenvector filtering procedure to produce full-order mode shapes that more closely match the measured active partition of the mode shapes using a set of modified Ritz vectors. The full dynamic residuals and full mode shapes are used as inputs to the minimum rank perturbation theory to provide an estimate of damage location and extent. The issues associated with this process are also discussed as drivers of near-term development activities to understand and improve this approach.

  1. A nuclear data approach for the Hubble constant measurements

    SciTech Connect

    Pritychenko, B.

    2015-06-09

    An extraordinary number of Hubble constant measurements challenges physicists with selection of the best numerical value. The standard U.S. Nuclear Data Program (USNDP) codes and procedures have been applied to resolve this issue. The nuclear data approach has produced the most probable or recommended Hubble constant value of 67.00(770) (km/sec)/Mpc. This recommended value is based on the last 25 years of experimental research and includes contributions from different types of measurements. The present result implies (14.6±1.7) x 109 years as a rough estimate for the age of the Universe. The complete list of recommended results is given and possible implications are discussed.

  2. A new approach in measuring graduate employability skills

    NASA Astrophysics Data System (ADS)

    Zakaria, Mohd Hafiz; Yatim, Bidin; Ismail, Suzilah

    2014-06-01

    Globalization makes graduate recruitment for an organization becomes more complex because employers believe that a holistic workforce is the key success of an organization. Currently, although graduates are said to possess specific skills but they still lack of employability skills, and this lead to increment of training cost either by government or even employers. Therefore, graduate level of employability skills should be evaluated before entering work market. In this study, a valid and reliable instrument embedding a new approach of measuring employability skills was developed using Situational Judgment Test (SJT). The instrument comprises of twelve (12) items measuring communication skill, professional ethics and morality, entrepreneurial skill, critical thinking in problem solving and personal quality. Instrument's validity was achieved through expert opinion and the reliability (in terms of stability) was based on the Chi-Square for homogeneity test. Generally, the instrument is beneficial to graduates, employers, government agencies, university, and workforce recruitment agencies when evaluating the level of employability skills.

  3. Measuring and monitoring IT using a balanced scorecard approach.

    PubMed

    Gash, Deborah J; Hatton, Todd

    2007-01-01

    Ensuring that the information technology department is aligned with the overall health system strategy and is performing at a consistently high level is a priority at Saint Luke's Health System in Kansas City, Mo. The information technology department of Saint Luke's Health System has been using the balanced scorecard approach described in this article to measure and monitor its performance for four years. This article will review the structure of the IT department's scorecard; the categories and measures used; how benchmarks are determined; how linkage to the organizational scorecard is made; how results are reported; how changes are made to the scorecard; and tips for using a scorecard in other IT departments. PMID:17583169

  4. Advances in Children's Rights and Children's Well-Being Measurement: Implications for School Psychologists

    ERIC Educational Resources Information Center

    Kosher, Hanita; Jiang, Xu; Ben-Arieh, Asher; Huebner, E. Scott

    2014-01-01

    Recent years have brought important changes to the profession of school psychology, influenced by larger social, scientific, and political trends. These trends include the emergence of children's rights agenda and advances in children's well-being measurement. During these years, a growing public attention and commitment to the notion of…

  5. ADVANCED REACTIVITY MEASUREMENT FACILITY, TRA660, INTERIOR. REACTOR INSIDE TANK. METAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ADVANCED REACTIVITY MEASUREMENT FACILITY, TRA-660, INTERIOR. REACTOR INSIDE TANK. METAL WORK PLATFORM ABOVE. THE REACTOR WAS IN A SMALL WATER-FILLED POOL. INL NEGATIVE NO. 66-6373. Unknown Photographer, ca. 1966 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  6. Advances in Treatment Integrity Research: Multidisciplinary Perspectives on the Conceptualization, Measurement, and Enhancement of Treatment Integrity

    ERIC Educational Resources Information Center

    Schulte, Ann C.; Easton, Julia E.; Parker, Justin

    2009-01-01

    Documenting treatment integrity is an important issue in research and practice in any discipline concerned with prevention and intervention. However, consensus concerning the dimensions of treatment integrity and how they should be measured has yet to emerge. Advances from three areas in which significant treatment integrity work has taken…

  7. A two-stage DEA approach for environmental efficiency measurement.

    PubMed

    Song, Malin; Wang, Shuhong; Liu, Wei

    2014-05-01

    The slacks-based measure (SBM) model based on the constant returns to scale has achieved some good results in addressing the undesirable outputs, such as waste water and water gas, in measuring environmental efficiency. However, the traditional SBM model cannot deal with the scenario in which desirable outputs are constant. Based on the axiomatic theory of productivity, this paper carries out a systematic research on the SBM model considering undesirable outputs, and further expands the SBM model from the perspective of network analysis. The new model can not only perform efficiency evaluation considering undesirable outputs, but also calculate desirable and undesirable outputs separately. The latter advantage successfully solves the "dependence" problem of outputs, that is, we can not increase the desirable outputs without producing any undesirable outputs. The following illustration shows that the efficiency values obtained by two-stage approach are smaller than those obtained by the traditional SBM model. Our approach provides a more profound analysis on how to improve environmental efficiency of the decision making units.

  8. Performance of current measurement system in poloidal field power supply for Experimental Advanced Superconducting Tokamak

    NASA Astrophysics Data System (ADS)

    Liu, D. M.; Li, J.; Wan, B. N.; Lu, Z.; Wang, L. S.; Jiang, L.; Lu, C. H.; Huang, J.

    2016-11-01

    As one of the core subsystems of the Experimental Advanced Superconducting Tokamak (EAST), the poloidal field power system supplies energy to EAST's superconducting coils. To measure the converter current in the poloidal field power system, a current measurement system has been designed. The proposed measurement system is composed of a Rogowski coil and a newly designed integrator. The results of the resistor-inductor-capacitor discharge test and the converter equal current test show that the current measurement system provides good reliability and stability, and the maximum error of the proposed system is less than 1%.

  9. Risk management measures for chemicals: the "COSHH essentials" approach.

    PubMed

    Garrod, A N I; Evans, P G; Davy, C W

    2007-12-01

    "COSHH essentials" was developed in Great Britain to help duty holders comply with the Control of Substances Hazardous to Health (COSHH) Regulations. It uses a similar approach to that described in the new European "REACH" Regulation (Registration, Evaluation, Authorisation and Restriction of Chemicals; EC No. 1907/2006 of the European Parliament), insofar as it identifies measures for managing the risk for specified exposure scenarios. It can therefore assist REACH duty holders with the identification and communication of appropriate risk-management measures. The technical basis for COSHH essentials is explained in the original papers published in the Annals of Occupational Hygiene. Its details will, therefore, not be described here; rather, its ability to provide a suitable means for communicating risk-management measures will be explored. COSHH essentials is a simple tool based on an empirical approach to risk assessment and risk management. The output is a "Control Guidance Sheet" that lists the "dos" and "don'ts" for control in a specific task scenario. The guidance in COSHH essentials recognises that exposure in the workplace will depend not just on mechanical controls, but also on a number of other factors, including administrative and behavioural controls, such as systems of work, supervision and training. In 2002, COSHH essentials was made freely available via the internet (http://www.coshh-essentials.org.uk/). This electronic delivery enabled links to be made between product series that share tasks, such as drum filling, and with ancillary guidance, such as setting up health surveillance for work with a respiratory sensitiser. COSHH essentials has proved to be a popular tool for communicating good control practice. It has attracted over 1 million visits to its site since its launch. It offers a common benchmark of good practice for chemical users, manufacturers, suppliers and importers, as well as regulators and health professionals.

  10. Risk management measures for chemicals: the "COSHH essentials" approach.

    PubMed

    Garrod, A N I; Evans, P G; Davy, C W

    2007-12-01

    "COSHH essentials" was developed in Great Britain to help duty holders comply with the Control of Substances Hazardous to Health (COSHH) Regulations. It uses a similar approach to that described in the new European "REACH" Regulation (Registration, Evaluation, Authorisation and Restriction of Chemicals; EC No. 1907/2006 of the European Parliament), insofar as it identifies measures for managing the risk for specified exposure scenarios. It can therefore assist REACH duty holders with the identification and communication of appropriate risk-management measures. The technical basis for COSHH essentials is explained in the original papers published in the Annals of Occupational Hygiene. Its details will, therefore, not be described here; rather, its ability to provide a suitable means for communicating risk-management measures will be explored. COSHH essentials is a simple tool based on an empirical approach to risk assessment and risk management. The output is a "Control Guidance Sheet" that lists the "dos" and "don'ts" for control in a specific task scenario. The guidance in COSHH essentials recognises that exposure in the workplace will depend not just on mechanical controls, but also on a number of other factors, including administrative and behavioural controls, such as systems of work, supervision and training. In 2002, COSHH essentials was made freely available via the internet (http://www.coshh-essentials.org.uk/). This electronic delivery enabled links to be made between product series that share tasks, such as drum filling, and with ancillary guidance, such as setting up health surveillance for work with a respiratory sensitiser. COSHH essentials has proved to be a popular tool for communicating good control practice. It has attracted over 1 million visits to its site since its launch. It offers a common benchmark of good practice for chemical users, manufacturers, suppliers and importers, as well as regulators and health professionals. PMID:17565355

  11. NASA Programs in Advanced Sensors and Measurement Technology for Aeronautical Applications

    NASA Technical Reports Server (NTRS)

    Conway, Bruce A.

    2004-01-01

    There are many challenges facing designers and operators of our next-generation aircraft in meeting the demands for efficiency, safety, and reliability which are will be imposed. This paper discusses aeronautical sensor requirements for a number of research and applications areas pertinent to the demands listed above. A brief overview will be given of aeronautical research measurements, along with a discussion of requirements for advanced technology. Also included will be descriptions of emerging sensors and instrumentation technology which may be exploited for enhanced research and operational capabilities. Finally, renewed emphasis of the National Aeronautics and Space Administration in advanced sensor and instrumentation technology development will be discussed, including project of technology advances over the next 5 years. Emphasis on NASA efforts to more actively advance the state-of-the-art in sensors and measurement techniques is timely in light of exciting new opportunities in airspace development and operation. An up-to-date summary of the measurement technology programs being established to respond to these opportunities is provided.

  12. A study of core Thomson scattering measurements in ITER using a multi-laser approach

    NASA Astrophysics Data System (ADS)

    Kurskiev, G. S.; Sdvizhenskii, P. A.; Bassan, M.; Andrew, P.; Bazhenov, A. N.; Bukreev, I. M.; Chernakov, P. V.; Kochergin, M. M.; Kukushkin, A. B.; Kukushkin, A. S.; Mukhin, E. E.; Razdobarin, A. G.; Samsonov, D. S.; Semenov, V. V.; Tolstyakov, S. Yu.; Kajita, S.; Masyukevich, S. V.

    2015-05-01

    The electron component is the main channel for anomalous power loss and the main indicator of transient processes in the tokamak plasma. The electron temperature and density profiles mainly determine the operational mode of the machine. This imposes demanding requirements on the precision and on the spatial and temporal resolution of the Thomson scattering (TS) measurements. Measurements of such high electron temperature with good accuracy in a large fusion device such as ITER using TS encounter a number of physical problems. The 40 keV TS spectrum has a significant blue shift. Due to the transmission functions of the fibres and to their darkening that can occur under a strong neutron irradiation, the operational wavelength range is bounded on the blue side. For example, high temperature measurements become impossible with the 1064 nm probing wavelength since the TS signal within the boundaries of the operational window weakly depends on Te. The second problem is connected with the TS calibration. The TS system for a large fusion machine like ITER will have a set of optical components inaccessible for maintenance, and their spectral characteristics may change with time. Since the present concept of the TS system for ITER relies on the classical approach to measuring the shape of the scattered spectra using wide spectral channels, the diagnostic will be very sensitive to the changes in the optical transmission. The third complication is connected with the deviation of the electron velocity distribution function from a Maxwellian that can happen under a strong ECRH/ECCD, and it may additionally hamper the measurements. This paper analyses the advantages of a ‘multi-laser approach’ implementation for the current design of the core TS system. Such an approach assumes simultaneous plasma probing with different wavelengths that allows the measurement accuracy to be improved significantly and to perform the spectral calibration of the TS system. Comparative analysis

  13. Amplification limit of weak measurements: A variational approach

    NASA Astrophysics Data System (ADS)

    Pang, Shengshi; Brun, Todd A.; Wu, Shengjun; Chen, Zeng-Bing

    2014-07-01

    Postselected weak measurement has been widely used in experiments to observe weak effects in various physical systems. However, it is still unclear how large the amplification ability of a weak measurement can be and what determines the limit of this ability, which is fundamental to understanding and applying weak measurements. The limitation of the conventional weak-value formalism for this problem is the divergence of weak values when the pre- and postselections are nearly orthogonal. In this paper, we study this problem by a variational approach for a general Hamiltonian Hint=gA⊗Ωδ(t-t0),g≪1. We derive a general asymptotic solution and show that the amplification limit is essentially independent of g and is determined by only the initial state of the detector and the number of distinct eigenvalues of A or Ω. An example of spin-1/2 particles with a pair of Stern-Gerlach devices is given to illustrate the results. The limiting case of continuous-variable systems is also investigated to demonstrate the influence of system dimension on the amplification limit.

  14. Advances in Landslide Nowcasting: Evaluation of a Global and Regional Modeling Approach

    NASA Technical Reports Server (NTRS)

    Kirschbaum, Dalia Bach; Peters-Lidard, Christa; Adler, Robert; Hong, Yang; Kumar, Sujay; Lerner-Lam, Arthur

    2011-01-01

    The increasing availability of remotely sensed data offers a new opportunity to address landslide hazard assessment at larger spatial scales. A prototype global satellite-based landslide hazard algorithm has been developed to identify areas that may experience landslide activity. This system combines a calculation of static landslide susceptibility with satellite-derived rainfall estimates and uses a threshold approach to generate a set of nowcasts that classify potentially hazardous areas. A recent evaluation of this algorithm framework found that while this tool represents an important first step in larger-scale near real-time landslide hazard assessment efforts, it requires several modifications before it can be fully realized as an operational tool. This study draws upon a prior work s recommendations to develop a new approach for considering landslide susceptibility and hazard at the regional scale. This case study calculates a regional susceptibility map using remotely sensed and in situ information and a database of landslides triggered by Hurricane Mitch in 1998 over four countries in Central America. The susceptibility map is evaluated with a regional rainfall intensity duration triggering threshold and results are compared with the global algorithm framework for the same event. Evaluation of this regional system suggests that this empirically based approach provides one plausible way to approach some of the data and resolution issues identified in the global assessment. The presented methodology is straightforward to implement, improves upon the global approach, and allows for results to be transferable between regions. The results also highlight several remaining challenges, including the empirical nature of the algorithm framework and adequate information for algorithm validation. Conclusions suggest that integrating additional triggering factors such as soil moisture may help to improve algorithm performance accuracy. The regional algorithm scenario

  15. Mission simulation as an approach to develop requirements for automation in Advanced Life Support Systems

    NASA Technical Reports Server (NTRS)

    Erickson, J. D.; Eckelkamp, R. E.; Barta, D. J.; Dragg, J.; Henninger, D. L. (Principal Investigator)

    1996-01-01

    This paper examines mission simulation as an approach to develop requirements for automation and robotics for Advanced Life Support Systems (ALSS). The focus is on requirements and applications for command and control, control and monitoring, situation assessment and response, diagnosis and recovery, adaptive planning and scheduling, and other automation applications in addition to mechanized equipment and robotics applications to reduce the excessive human labor requirements to operate and maintain an ALSS. Based on principles of systems engineering, an approach is proposed to assess requirements for automation and robotics using mission simulation tools. First, the story of a simulated mission is defined in terms of processes with attendant types of resources needed, including options for use of automation and robotic systems. Next, systems dynamics models are used in simulation to reveal the implications for selected resource allocation schemes in terms of resources required to complete operational tasks. The simulations not only help establish ALSS design criteria, but also may offer guidance to ALSS research efforts by identifying gaps in knowledge about procedures and/or biophysical processes. Simulations of a planned one-year mission with 4 crewmembers in a Human Rated Test Facility are presented as an approach to evaluation of mission feasibility and definition of automation and robotics requirements.

  16. Recent advances in innovative therapeutic approaches for Duchenne muscular dystrophy: from discovery to clinical trials

    PubMed Central

    Shimizu-Motohashi, Yuko; Miyatake, Shouta; Komaki, Hirofumi; Takeda, Shin’ichi; Aoki, Yoshitsugu

    2016-01-01

    Duchenne muscular dystrophy (DMD) is an X-linked progressive degenerative muscle disorder caused by the absence of dystrophin. There is no curative therapy, although innovative therapeutic approaches have been aggressively investigated over recent years. Currently, the international clinical trial registry platform for this disease has been constructed and clinical trials for innovative therapeutic approaches are underway. Among these, exon skipping and read-through of nonsense mutations are in the most advanced stages, with exon skipping theoretically applicable to a larger number of patients. To date, exon skipping that targets exons 51, 44, 45, and 53 is being globally investigated including in USA, EU, and Japan. The latest announcement from Japan was made, demonstrating successful dystrophin production in muscles of patients with DMD after treating with exon 53 skipping antisense oligonucleotides (ASOs). However, the innovative therapeutic approaches have demonstrated limited efficacy. To address this issue in exon skipping, studies to unveil the mechanism underlying gymnotic delivery of ASO uptake in living cells have been conducted in an effort to improve in vivo delivery. Further, establishing the infrastructures to integrate multi-institutional clinical trials are needed to facilitate the development of successful therapies for DMD, which ultimately is applicable to other myopathies and neurodegenerative diseases, including spinal muscular atrophy and motor neuron diseases. PMID:27398133

  17. Recent advances in innovative therapeutic approaches for Duchenne muscular dystrophy: from discovery to clinical trials.

    PubMed

    Shimizu-Motohashi, Yuko; Miyatake, Shouta; Komaki, Hirofumi; Takeda, Shin'ichi; Aoki, Yoshitsugu

    2016-01-01

    Duchenne muscular dystrophy (DMD) is an X-linked progressive degenerative muscle disorder caused by the absence of dystrophin. There is no curative therapy, although innovative therapeutic approaches have been aggressively investigated over recent years. Currently, the international clinical trial registry platform for this disease has been constructed and clinical trials for innovative therapeutic approaches are underway. Among these, exon skipping and read-through of nonsense mutations are in the most advanced stages, with exon skipping theoretically applicable to a larger number of patients. To date, exon skipping that targets exons 51, 44, 45, and 53 is being globally investigated including in USA, EU, and Japan. The latest announcement from Japan was made, demonstrating successful dystrophin production in muscles of patients with DMD after treating with exon 53 skipping antisense oligonucleotides (ASOs). However, the innovative therapeutic approaches have demonstrated limited efficacy. To address this issue in exon skipping, studies to unveil the mechanism underlying gymnotic delivery of ASO uptake in living cells have been conducted in an effort to improve in vivo delivery. Further, establishing the infrastructures to integrate multi-institutional clinical trials are needed to facilitate the development of successful therapies for DMD, which ultimately is applicable to other myopathies and neurodegenerative diseases, including spinal muscular atrophy and motor neuron diseases.

  18. COST-ES0601: Advances in homogenisation methods of climate series: an integrated approach (HOME)

    NASA Astrophysics Data System (ADS)

    Mestre, O.; Auer, I.; Venema, V.; Stepanek, P.; Szentimrey, T.; Grimvall, A.; Aguilar, E.

    2009-04-01

    The COST Action ES0601: Advances in homogenisation methods of climate series: an integrated approach is nearing the end of its second year of life. The action is intended to provide the best possible tools for the homogenization of time series to the climate research community. The involved scientists have done remarkable progress since COST Action ES0601 was launched (see www.homogenisation.org). HOME has started with a literature review and a survey to the research community to identify those climatic elements and homogenisation techniques to be considered during the action. This allowed the preparation of the benchmark monthly dataset to be used during the remaining time of the action. This monthly benchmark contains real temperature and precipitation data (with real inhomogeneities), as well as synthetic and surrogate networks, including artificially produced missing values, outliers, local trends and break inhomogeneities which are inserted at the usual rate, size and distribution found in actual networks. The location of the outliers and change points is undisclosed to the HOME scientists, who are, at present, applying different homogenisation approaches and uploading the results, to analyse the performances of their techniques. Everyone who works on the homogenization of climate data is cordially invited to join this exercise. HOME is also working on the production of a daily benchmark dataset, to reproduce the experiment described above, but in a lower temporal resolution, and on the preparation of freely available homogenization tools, including the best performing approaches.

  19. Measuring energy efficiency in economics: Shadow value approach

    NASA Astrophysics Data System (ADS)

    Khademvatani, Asgar

    For decades, academic scholars and policy makers have commonly applied a simple average measure, energy intensity, for studying energy efficiency. In contrast, we introduce a distinctive marginal measure called energy shadow value (SV) for modeling energy efficiency drawn on economic theory. This thesis demonstrates energy SV advantages, conceptually and empirically, over the average measure recognizing marginal technical energy efficiency and unveiling allocative energy efficiency (energy SV to energy price). Using a dual profit function, the study illustrates how treating energy as quasi-fixed factor called quasi-fixed approach offers modeling advantages and is appropriate in developing an explicit model for energy efficiency. We address fallacies and misleading results using average measure and demonstrate energy SV advantage in inter- and intra-country energy efficiency comparison. Energy efficiency dynamics and determination of efficient allocation of energy use are shown through factors impacting energy SV: capital, technology, and environmental obligations. To validate the energy SV, we applied a dual restricted cost model using KLEM dataset for the 35 US sectors stretching from 1958 to 2000 and selected a sample of the four sectors. Following the empirical results, predicted wedges between energy price and the SV growth indicate a misallocation of energy use in stone, clay and glass (SCG) and communications (Com) sectors with more evidence in the SCG compared to the Com sector, showing overshoot in energy use relative to optimal paths and cost increases from sub-optimal energy use. The results show that energy productivity is a measure of technical efficiency and is void of information on the economic efficiency of energy use. Decomposing energy SV reveals that energy, capital and technology played key roles in energy SV increases helping to consider and analyze policy implications of energy efficiency improvement. Applying the marginal measure, we also

  20. Perspectives for the high field approach in fusion research and advances within the Ignitor Program

    NASA Astrophysics Data System (ADS)

    Coppi, B.; Airoldi, A.; Albanese, R.; Ambrosino, G.; Belforte, G.; Boggio-Sella, E.; Cardinali, A.; Cenacchi, G.; Conti, F.; Costa, E.; D'Amico, A.; Detragiache, P.; De Tommasi, G.; DeVellis, A.; Faelli, G.; Ferraris, P.; Frattolillo, A.; Giammanco, F.; Grasso, G.; Lazzaretti, M.; Mantovani, S.; Merriman, L.; Migliori, S.; Napoli, R.; Perona, A.; Pierattini, S.; Pironti, A.; Ramogida, G.; Rubinacci, G.; Sassi, M.; Sestero, A.; Spillantini, S.; Tavani, M.; Tumino, A.; Villone, F.; Zucchi, L.

    2015-05-01

    The Ignitor Program maintains the objective of approaching D-T ignition conditions by incorporating systematical advances made with relevant high field magnet technology and with experiments on high density well confined plasmas in the present machine design. An additional objective is that of charting the development of the high field line of experiments that goes from the Alcator machine to the ignitor device. The rationale for this class of experiments, aimed at producing poloidal fields with the highest possible values (compatible with proven safety factors of known plasma instabilities) is given. On the basis of the favourable properties of high density plasmas produced systematically by this line of machines, the envisioned future for the line, based on novel high field superconducting magnets, includes the possibility of investigating more advanced fusion burn conditions than those of the D-T plasmas for which Ignitor is designed. Considering that a detailed machine design has been carried out (Coppi et al 2013 Nucl. Fusion 53 104013), the advances made in different areas of the physics and technology that are relevant to the Ignitor project are reported. These are included within the following sections of the present paper: main components issues, assembly and welding procedures; robotics criteria; non-linear feedback control; simulations with three-dimensional structures and disruption studies; ICRH and dedicated diagnostics systems; anomalous transport processes including self-organization for fusion burning regimes and the zero-dimensional model; tridimensional structures of the thermonuclear instability and control provisions; superconducting components of the present machine; envisioned experiments with high field superconducting magnets.

  1. Novel Approaches to Treatment of Advanced Melanoma: A Review on Targeted Therapy and Immunotherapy

    PubMed Central

    Niezgoda, Anna; Niezgoda, Piotr; Czajkowski, Rafał

    2015-01-01

    The incidence of malignant melanoma is increasing. The majority of patients are diagnosed in early stages when the disease is highly curable. However, the more advanced or metastatic cases have always been a challenge for clinicians. The poor prognosis for patients with melanoma is now changing as numerous of promising approaches have appeared recently. The discovery of aberrations of pathways responsible for intracellular signal transduction allowed us to introduce agents specifically targeting the mutated cascades. Numerous clinical studies have been conducted to improve effectiveness of melanoma treatment. From 2011 until now, the U.S. FDA has approved seven novel agents, such as BRAF-inhibitors (vemurafenib 2011, dabrafenib 2013), MEK-inhibitors (trametinib 2013), anti-PD1 antibodies (nivolumab 2014, pembrolizumab 2014), anti-CTLA-4 antibody (ipilimumab 2011), or peginterferon-alfa-2b (2011) intended to be used in most advanced cases of melanoma. Nevertheless, clinicians continue working on new possible methods of treatment as resistance to the novel drugs is a commonly observed problem. This paper is based on latest data published until the end of January 2015. PMID:26171394

  2. Identifying human disease genes: advances in molecular genetics and computational approaches.

    PubMed

    Bakhtiar, S M; Ali, A; Baig, S M; Barh, D; Miyoshi, A; Azevedo, V

    2014-07-04

    The human genome project is one of the significant achievements that have provided detailed insight into our genetic legacy. During the last two decades, biomedical investigations have gathered a considerable body of evidence by detecting more than 2000 disease genes. Despite the imperative advances in the genetic understanding of various diseases, the pathogenesis of many others remains obscure. With recent advances, the laborious methodologies used to identify DNA variations are replaced by direct sequencing of genomic DNA to detect genetic changes. The ability to perform such studies depends equally on the development of high-throughput and economical genotyping methods. Currently, basically for every disease whose origen is still unknown, genetic approaches are available which could be pedigree-dependent or -independent with the capacity to elucidate fundamental disease mechanisms. Computer algorithms and programs for linkage analysis have formed the foundation for many disease gene detection projects, similarly databases of clinical findings have been widely used to support diagnostic decisions in dysmorphology and general human disease. For every disease type, genome sequence variations, particularly single nucleotide polymorphisms are mapped by comparing the genetic makeup of case and control groups. Methods that predict the effects of polymorphisms on protein stability are useful for the identification of possible disease associations, whereas structural effects can be assessed using methods to predict stability changes in proteins using sequence and/or structural information.

  3. Advances in regenerative therapies for spinal cord injury: a biomaterials approach

    PubMed Central

    Tsintou, Magdalini; Dalamagkas, Kyriakos; Seifalian, Alexander Marcus

    2015-01-01

    Spinal cord injury results in the permanent loss of function, causing enormous personal, social and economic problems. Even though neural regeneration has been proven to be a natural mechanism, central nervous system repair mechanisms are ineffective due to the imbalance of the inhibitory and excitatory factors implicated in neuroregeneration. Therefore, there is growing research interest on discovering a novel therapeutic strategy for effective spinal cord injury repair. To this direction, cell-based delivery strategies, biomolecule delivery strategies as well as scaffold-based therapeutic strategies have been developed with a tendency to seek for the answer to a combinatorial approach of all the above. Here we review the recent advances on regenerative/neural engineering therapies for spinal cord injury, aiming at providing an insight to the most promising repair strategies, in order to facilitate future research conduction. PMID:26109946

  4. Numerical approach for the voloxidation process of an advanced spent fuel conditioning process (ACP)

    SciTech Connect

    Park, Byung Heung; Jeong, Sang Mun; Seo, Chung-Seok

    2007-07-01

    A voloxidation process is adopted as the first step of an advanced spent fuel conditioning process in order to prepare the SF oxide to be reduced in the following electrolytic reduction process. A semi-batch type voloxidizer was devised to transform a SF pellet into powder. In this work, a simple reactor model was developed for the purpose of correlating a gas phase flow rate with an operation time as a numerical approach. With an assumption that a solid phase and a gas phase are homogeneous in a reactor, a reaction rate for an oxidation was introduced into a mass balance equation. The developed equation can describe a change of an outlet's oxygen concentration including such a case that a gas flow is not sufficient enough to continue a reaction at its maximum reaction rate. (authors)

  5. Oxygen Penalty for Waste Oxidation in an Advanced Life Support System: A Systems Approach

    NASA Technical Reports Server (NTRS)

    Pisharody, Suresh; Wignarajah, K.; Fisher, John

    2002-01-01

    Oxidation is one of a number of technologies that are being considered for waste management and resource recovery from waste materials generated on board space missions. Oxidation processes are a very effective and efficient means of clean and complete conversion of waste materials to sterile products. However, because oxidation uses oxygen there is an "oxygen penalty" associated either with resupply of oxygen or with recycling oxygen from some other source. This paper is a systems approach to the issue of oxygen penalty in life support systems and presents findings on the oxygen penalty associated with an integrated oxidation-Sabatier-Oxygen Generation System (OGS) for waste management in an Advanced Life Support System. The findings reveal that such an integrated system can be operated to form a variety of useful products without a significant oxygen penalty.

  6. A thermodynamic approach for advanced fuels of gas-cooled reactors

    NASA Astrophysics Data System (ADS)

    Guéneau, C.; Chatain, S.; Gossé, S.; Rado, C.; Rapaud, O.; Lechelle, J.; Dumas, J. C.; Chatillon, C.

    2005-09-01

    For both high temperature reactor (HTR) and gas cooled fast reactor (GFR) systems, the high operating temperature in normal and accidental conditions necessitates the assessment of the thermodynamic data and associated phase diagrams for the complex system constituted of the fuel kernel, the inert materials and the fission products. A classical CALPHAD approach, coupling experiments and thermodynamic calculations, is proposed. Some examples of studies are presented leading with the CO and CO 2 gas formation during the chemical interaction of [UO 2± x/C] in the HTR particle, and the chemical compatibility of the couples [UN/SiC], [(U, Pu)N/SiC], [(U, Pu)N/TiN] for the GFR system. A project of constitution of a thermodynamic database for advanced fuels of gas-cooled reactors is proposed.

  7. A Novel Microcharacterization Technique in the Measurement of Strain and Orientation Gradient in Advanced Materials

    NASA Technical Reports Server (NTRS)

    Garmestai, H.; Harris, K.; Lourenco, L.

    1997-01-01

    Representation of morphology and evolution of the microstructure during processing and their relation to properties requires proper experimental techniques. Residual strains, lattice distortion, and texture (micro-texture) at the interface and the matrix of a layered structure or a functionally gradient material and their variation are among parameters important in materials characterization but hard to measure with present experimental techniques. Current techniques available to measure changes in interred material parameters (residual stress, micro-texture, microplasticity) produce results which are either qualitative or unreliable. This problem becomes even more complicated in the case of a temperature variation. These parameters affect many of the mechanical properties of advanced materials including stress-strain relation, ductility, creep, and fatigue. A review of some novel experimental techniques using recent advances in electron microscopy is presented here to measure internal stress, (micro)texture, interracial strength and (sub)grain formation and realignment. Two of these techniques are combined in the chamber of an Environmental Scanning Electron Microscope to measure strain and orientation gradients in advanced materials. These techniques which include Backscattered Kikuchi Diffractometry (BKD) and Microscopic Strain Field Analysis are used to characterize metallic and intermetallic matrix composites and superplastic materials. These techniques are compared with the more conventional x-ray diffraction and indentation techniques.

  8. Identifying Successful Advancement Approaches in Four Catholic Universities: The Effectiveness of the Four Advancement Models of Communication

    ERIC Educational Resources Information Center

    Bonglia, Jean-Pierre K.

    2010-01-01

    The current longitudinal study of the most successful Catholic universities in the United States identifies the prevalence of four advancement models of communication that have contributed to make those institutions successful in their philanthropic efforts. While research by Grunig and Kelly maintained that the two-way symmetrical model of…

  9. Remote Bridge Deflection Measurement Using an Advanced Video Deflectometer and Actively Illuminated LED Targets.

    PubMed

    Tian, Long; Pan, Bing

    2016-01-01

    An advanced video deflectometer using actively illuminated LED targets is proposed for remote, real-time measurement of bridge deflection. The system configuration, fundamental principles, and measuring procedures of the video deflectometer are first described. To address the challenge of remote and accurate deflection measurement of large engineering structures without being affected by ambient light, the novel idea of active imaging, which combines high-brightness monochromatic LED targets with coupled bandpass filter imaging, is introduced. Then, to examine the measurement accuracy of the proposed advanced video deflectometer in outdoor environments, vertical motions of an LED target with precisely-controlled translations were measured and compared with prescribed values. Finally, by tracking six LED targets mounted on the bridge, the developed video deflectometer was applied for field, remote, and multipoint deflection measurement of the Wuhan Yangtze River Bridge, one of the most prestigious and most publicized constructions in China, during its routine safety evaluation tests. Since the proposed video deflectometer using actively illuminated LED targets offers prominent merits of remote, contactless, real-time, and multipoint deflection measurement with strong robustness against ambient light changes, it has great potential in the routine safety evaluation of various bridges and other large-scale engineering structures. PMID:27563901

  10. Remote Bridge Deflection Measurement Using an Advanced Video Deflectometer and Actively Illuminated LED Targets

    PubMed Central

    Tian, Long; Pan, Bing

    2016-01-01

    An advanced video deflectometer using actively illuminated LED targets is proposed for remote, real-time measurement of bridge deflection. The system configuration, fundamental principles, and measuring procedures of the video deflectometer are first described. To address the challenge of remote and accurate deflection measurement of large engineering structures without being affected by ambient light, the novel idea of active imaging, which combines high-brightness monochromatic LED targets with coupled bandpass filter imaging, is introduced. Then, to examine the measurement accuracy of the proposed advanced video deflectometer in outdoor environments, vertical motions of an LED target with precisely-controlled translations were measured and compared with prescribed values. Finally, by tracking six LED targets mounted on the bridge, the developed video deflectometer was applied for field, remote, and multipoint deflection measurement of the Wuhan Yangtze River Bridge, one of the most prestigious and most publicized constructions in China, during its routine safety evaluation tests. Since the proposed video deflectometer using actively illuminated LED targets offers prominent merits of remote, contactless, real-time, and multipoint deflection measurement with strong robustness against ambient light changes, it has great potential in the routine safety evaluation of various bridges and other large-scale engineering structures. PMID:27563901

  11. Advanced digital speckle correlation method for strain measurement and nondestructive testing

    NASA Astrophysics Data System (ADS)

    Jin, Guan-chang; Bao, Nai-Keng; Chung, Po Sheun

    1997-03-01

    An advanced digital speckle correlation method (DSCM) is presented in this paper. The advantages of this method will not only improve the processing speed but also increase the measuring accuracy. Some mathematics tools are derived and a powerful computing program is developed for further applications. A new feature of the measuring sensitivity of DSCM that can be varied by different amplification of the optical arrangement is first presented. This advantage may be superior to those available in other optical metrology methods like Electronic Speckle Pattern Interferometry (ESPI) in micro-deformation measurements. The applications of strain measurement and nondestructive testing are described and the advantages of DSCM are obvious. Some examples of material behavior measurement and plastic strain measurement are presented. Due to the high sensitivity of DSCM, another potential application in nondestructive testing (NDT) is also described in this paper. From the application examples given, this advanced DSCM proves to be a new and effective optical strain sensing technique especially for small objects or micro-deformation measurements.

  12. Fourier transform approach in modulation technique of experimental measurements.

    PubMed

    Khazimullin, M V; Lebedev, Yu A

    2010-04-01

    An application of Fourier transform approach in modulation technique of experimental studies is considered. This method has obvious advantages compared with traditional lock-in amplifiers technique--simple experimental setup, a quickly available information on all the required harmonics, high speed of data processing using fast Fourier transform algorithm. A computationally simple, fast and accurate Fourier coefficients interpolation (FCI) method has been implemented to obtain a useful information from harmonics of a multimode signal. Our analysis shows that in this case FCI method has a systematical error (bias) of a signal parameters estimation, which became essential for the short data sets. Hence, a new differential Fourier coefficients interpolation (DFCI) method has been suggested, which is less sensitive to a presence of several modes in a signal. The analysis has been confirmed by simulations and measurements of a quartz wedge birefringence by means of the photoelastic modulator. The obtained bias, noise level, and measuring speed are comparable and even better than in lock-in amplifier technique. Moreover, presented DFCI method is expected to be promised candidate for using in actively developing imaging systems based on the modulation technique requiring fast digital signal processing of large data sets.

  13. Differentiated cell behavior: a multiscale approach using measure theory.

    PubMed

    Colombi, Annachiara; Scianna, Marco; Tosin, Andrea

    2015-11-01

    This paper deals with the derivation of a collective model of cell populations out of an individual-based description of the underlying physical particle system. By looking at the spatial distribution of cells in terms of time-evolving measures, rather than at individual cell paths, we obtain an ensemble representation stemming from the phenomenological behavior of the single component cells. In particular, as a key advantage of our approach, the scale of representation of the system, i.e., microscopic/discrete vs. macroscopic/continuous, can be chosen a posteriori according only to the spatial structure given to the aforesaid measures. The paper focuses in particular on the use of different scales based on the specific functions performed by cells. A two-population hybrid system is considered, where cells with a specialized/differentiated phenotype are treated as a discrete population of point masses while unspecialized/undifferentiated cell aggregates are represented by a continuous approximation. Numerical simulations and analytical investigations emphasize the role of some biologically relevant parameters in determining the specific evolution of such a hybrid cell system.

  14. Measurement approaches to support future warhead arms control transparency

    SciTech Connect

    Olinger, C.T.; Frankle, C.M.; Johnson, M.W.; Poths, J.

    1998-12-31

    Transparency on warhead stockpiles, warhead dismantlement, and fissile material stockpiles in nuclear weapons states will become increasingly important in the move beyond START II toward lower quantities of warheads. Congressional support for further warhead reductions will likely depend on the degree of irreversibility, or in other words, the rapidity with which warhead inventories could be reconstituted. Whether irreversibility considerations can be satisfied will depend on monitoring dismantlement as well as constraining the available stockpile of fissile materials for possible refabrication into warheads. Measurement techniques designed to address the above problems will need to consider NPT Article 1 obligations as well as Russian and US classification regulations, which prohibit or restrict the transfer of nuclear warhead design information to other states. Classification considerations currently limit the potential completeness of future inspections of weapons materials. Many conventional international safeguards approaches are not currently viable for arms control applications because they would reveal weapons design information. The authors discuss a variety of technical measures that may help to improve transparence of warhead and fissile material stockpiles and may enable limited warhead dismantlement transparency.

  15. Bioengineering approach to non-invasive measurement of body composition.

    PubMed

    Dubin, S; Nissanov, J; Zietz, S; Schrope, B; Naim, A; Morano, R; Hanania, R

    1994-01-01

    Measurement of body fat percentage is essential for medical care and research. The "gold standard" method for humans is underwater weighing, which is clearly inappropriate for infants, sick people and non-human animals. The corresponding criterion method for animals is comminution of the carcass followed by extraction of the fat with a volatile solvent such as ether. Our goal has been to develop a method for body composition (fat percentage) for use in animals and humans which is non-invasive and minimally intrusive, independent of variation in body conformation and fat distribution, and reasonable in cost. In one variant, our approach to this problem has been to move Archimedes' principle "on to dry land." The subject's volume is determined by measuring the differential buoyancy in comfortably breathable light (low density) and heavy atmospheres. In another, we use "structured light," in which a pattern of illumination is cast on the patient. The image is acquired using a video camera and the geometrical spatial coordinates of a large number of points on the surface of the subject are acquired. This permits the computation of the surface area and volume of the subject; which, combined with the weight, determines the fat percentage. PMID:7948641

  16. Development Approach of the Advanced Life Support On-line Project Information System

    NASA Technical Reports Server (NTRS)

    Levri, Julie A.; Hogan, John A.; Morrow, Rich; Ho, Michael C.; Kaehms, Bob; Cavazzoni, Jim; Brodbeck, Christina A.; Whitaker, Dawn R.

    2005-01-01

    The Advanced Life Support (ALS) Program has recently accelerated an effort to develop an On-line Project Information System (OPIS) for research project and technology development data centralization and sharing. There has been significant advancement in the On-line Project Information System (OPIS) over the past year (Hogan et al, 2004). This paper presents the resultant OPIS development approach. OPIS is being built as an application framework consisting of an uderlying Linux/Apache/MySQL/PHP (LAMP) stack, and supporting class libraries that provides database abstraction and automatic code generation, simplifying the ongoing development and maintenance process. Such a development approach allows for quick adaptation to serve multiple Programs, although initial deployment is for an ALS module. OPIS core functionality will involve a Web-based annual solicitation of project and technology data directly from ALS Principal Investigators (PIs) through customized data collection forms. Data provided by PIs will be reviewed by a Technical Task Monitor (TTM) before posting the information to OPIS for ALS Community viewing via the Web. Such Annual Reports will be permanent, citable references within OPIS. OPlS core functionality will also include Project Home Sites, which will allow PIS to provide updated technology information to the Community in between Annual Report updates. All data will be stored in an object-oriented relational database, created in MySQL(Reistered Trademark) and located on a secure server at NASA Ames Research Center (ARC). Upon launch, OPlS can be utilized by Managers to identify research and technology development (R&TD) gaps and to assess task performance. Analysts can employ OPlS to obtain the current, comprehensive, accurate information about advanced technologies that is required to perform trade studies of various life support system options. ALS researchers and technology developers can use OPlS to achieve an improved understanding of the NASA

  17. Advanced digital methods for blood flow flux analysis using µPIV approach

    NASA Astrophysics Data System (ADS)

    Kurochkin, Maxim A.; Timoshina, Polina A.; Fedosov, Ivan V.; Tuchin, Valery V.

    2015-03-01

    A digital optical system focused on work with laboratory animals for intravital capillaroscopy has been developed. It implements the particle image velocimetry (PIV) based approach for measurements of red blood cells velocity in laboratory rat stomach capillaries. We propose a method of involuntary displacement compensation of the capillary network images. Image stabilization algorithm is based on correlation of feature tracking. The efficiency of designed image stabilization algorithm was experimentally demonstrated. The results of capillary blood flow analysis are demonstrated.

  18. An Assessment of Wind Plant Complex Flows Using Advanced Doppler Radar Measurements

    NASA Astrophysics Data System (ADS)

    Gunter, W. S.; Schroeder, J.; Hirth, B.; Duncan, J.; Guynes, J.

    2015-12-01

    As installed wind energy capacity continues to steadily increase, the need for comprehensive measurements of wind plant complex flows to further reduce the cost of wind energy has been well advertised by the industry as a whole. Such measurements serve diverse perspectives including resource assessment, turbine inflow and power curve validation, wake and wind plant layout model verification, operations and maintenance, and the development of future advanced wind plant control schemes. While various measurement devices have been matured for wind energy applications (e.g. meteorological towers, LIDAR, SODAR), this presentation will focus on the use of advanced Doppler radar systems to observe the complex wind flows within and surrounding wind plants. Advanced Doppler radars can provide the combined advantage of a large analysis footprint (tens of square kilometers) with rapid data analysis updates (a few seconds to one minute) using both single- and dual-Doppler data collection methods. This presentation demonstrates the utility of measurements collected by the Texas Tech University Ka-band (TTUKa) radars to identify complex wind flows occurring within and nearby operational wind plants, and provide reliable forecasts of wind speeds and directions at given locations (i.e. turbine or instrumented tower sites) 45+ seconds in advance. Radar-derived wind maps reveal commonly observed features such as turbine wakes and turbine-to-turbine interaction, high momentum wind speed channels between turbine wakes, turbine array edge effects, transient boundary layer flow structures (such as wind streaks, frontal boundaries, etc.), and the impact of local terrain. Operational turbine or instrumented tower data are merged with the radar analysis to link the observed complex flow features to turbine and wind plant performance.

  19. Scenarios and performance measures for advanced ISDN satellite design and experiments

    NASA Technical Reports Server (NTRS)

    Pepin, Gerard R.

    1991-01-01

    Described here are the contemplated input and expected output for the Interim Service Integrated Services Digital Network (ISDN) Satellite (ISIS) and Full Service ISDN Satellite (FSIS) Models. The discrete event simulations of these models are presented with specific scenarios that stress ISDN satellite parameters. Performance measure criteria are presented for evaluating the advanced ISDN communication satellite designs of the NASA Satellite Communications Research (SCAR) Program.

  20. Advanced Placement Results, 2013-14. Measuring Up. D&A Report No.15.01

    ERIC Educational Resources Information Center

    Gilleland, Kevin; Muli, Juliana

    2015-01-01

    Advanced Placement (AP) outcomes for Wake County Public School System (WCPSS) students have continued an upward trend for over 18 years, out-performing the state and the nation in all measures. In 2013-14 there were 13,757 exams taken by 6,955 WCPSS test-takers with almost 76% of the exams resulting in scores at or above 3, outperforming Guilford…

  1. Measuring therapeutic alliance between oncologists and patients with advanced cancer: The Human Connection Scale

    PubMed Central

    Mack, Jennifer W; Block, Susan D.; Nilsson, Matthew; Wright, Alexi; Trice, Elizabeth; Friedlander, Robert; Paulk, Elizabeth; Prigerson, Holly G

    2009-01-01

    Objectives Patients consider having a human connection with a physician to be an important aspect of end-of-life (EOL) care. We sought to develop and validate a measure of therapeutic alliance between advanced cancer patients and their physicians, and to evaluate the effects of therapeutic alliance on EOL experiences and care. Methods We developed The Human Connection (THC) scale to measure the extent to which patients felt a sense of mutual understanding, caring, and trust with their physicians. The scale was administered to 217 advanced cancer patients along with measures of attributes hypothesized to be related to therapeutic alliance, including emotional acceptance of terminal illness. EOL outcomes in 90 patients who died during the study were also examined. Results The 16-item THC questionnaire was internally consistent (Cronbach’s α =.90) and valid, based on its expected positive association with emotional acceptance of the terminal illness (r=.31, P<.0001). THC scores were inversely related to symptom burden (r=−.19, P=.006), functional status (Karnofsky score, r=.22, P=.001), and mental illness (THC score 50.69 for patients with any DSM diagnosis versus 55.22 for those without, P=.03). THC scores were not significantly associated with EOL discussions (P=.68). Among patients who had died, EOL ICU care was inversely associated with therapeutic alliance (THC score 46.5 for those with ICU care versus 55.5 for those without, P=.002), such that patients with higher THC scores were less likely to spend time in the ICU during the last week of life. Conclusion The THC scale is a valid and reliable measure of therapeutic alliance between advanced cancer patients and their physicians. In addition, we found no evidence to suggest that EOL discussions harm patients’ therapeutic alliance. A strong therapeutic alliance is associated with emotional acceptance of a terminal illness and with decreased ICU care at the end of life among patients with advanced cancer

  2. Final Technical Report: Advanced Measurement and Analysis of PV Derate Factors.

    SciTech Connect

    King, Bruce Hardison; Burton, Patrick D.; Hansen, Clifford; Jones, Christian Birk

    2015-12-01

    The Advanced Measurement and Analysis of PV Derate Factors project focuses on improving the accuracy and reducing the uncertainty of PV performance model predictions by addressing a common element of all PV performance models referred to as “derates”. Widespread use of “rules of thumb”, combined with significant uncertainty regarding appropriate values for these factors contribute to uncertainty in projected energy production.

  3. Laser-velocimeter flow-field measurements of an advanced turboprop

    NASA Technical Reports Server (NTRS)

    Serafini, J. S.; Sullivan, J. P.; Neumann, H. E.

    1981-01-01

    Non-intrusive measurements of velocity about a spinner-propeller-nacelle configuration at a Mach number of 0.8 were performed. A laser velocimeter, specifically developed for these measurements in the NASA Lewis 8-foot by 6-foot Supersonic Wind Tunnel, was used to measure the flow-field of the advanced swept SR-3 turboprop. The laser velocimeter uses an argon ion laser and a 2-color optics system to allow simultaneous measurements of 2-components of velocity. The axisymmetric nature of the propeller-nacelle flow-field permits two separate 2 dimensonal measurements to be combined into 3 dimensional velocity data. Presented are data ahead of and behind the prop blades and also a limited set in between the blades. Aspects of the observed flow-field such as the tip vortex are discussed.

  4. Rapid Intelligent Inspection Process Definition for dimensional measurement in advanced manufacturing

    SciTech Connect

    Brown, C.W.

    1993-03-01

    The Rapid Intelligent Inspection Process Definition (RIIPD) project is an industry-led effort to advance computer integrated manufacturing (CIM) systems for the creation and modification of inspection process definitions. The RIIPD project will define, design, develop, and demonstrate an automated tool (i.e., software) to generate inspection process plans and coordinate measuring machine (CMM) inspection programs, as well as produce support information for the dimensional measurement of piece parts. The goal of this project is to make the inspection and part verification function, specifically CMM measurements, a more effective production support tool by reducing inspection process definition flowtime, creating consistent and standard inspections, increasing confidence of measurement results, and capturing inspection expertise. This objective is accomplished through importing STEP geometry definitions, applying solid modeling, incorporating explicit tolerance representations, establishing dimensional inspection,techniques, embedding artificial intelligence techniques, and adhering to the Dimensional Measuring Interface Standard (DMIS) national standard.

  5. Comparison of Pilots' Situational Awareness While Monitoring Autoland Approaches Using Conventional and Advanced Flight Display Formats

    NASA Technical Reports Server (NTRS)

    Kramer, Lynda J.; Busquets, Anthony M.

    2000-01-01

    A simulation experiment was performed to assess situation awareness (SA) and workload of pilots while monitoring simulated autoland operations in Instrument Meteorological Conditions with three advanced display concepts: two enhanced electronic flight information system (EFIS)-type display concepts and one totally synthetic, integrated pictorial display concept. Each concept incorporated sensor-derived wireframe runway and iconic depictions of sensor-detected traffic in different locations on the display media. Various scenarios, involving conflicting traffic situation assessments, main display failures, and navigation/autopilot system errors, were used to assess the pilots' SA and workload during autoland approaches with the display concepts. From the results, for each scenario, the integrated pictorial display concept provided the pilots with statistically equivalent or substantially improved SA over the other display concepts. In addition to increased SA, subjective rankings indicated that the pictorial concept offered reductions in overall pilot workload (in both mean ranking and spread) over the two enhanced EFIS-type display concepts. Out of the display concepts flown, the pilots ranked the pictorial concept as the display that was easiest to use to maintain situational awareness, to monitor an autoland approach, to interpret information from the runway and obstacle detecting sensor systems, and to make the decision to go around.

  6. Unequal-period combination approach of gray code and phase-shifting for 3-D visual measurement

    NASA Astrophysics Data System (ADS)

    Yu, Shuang; Zhang, Jing; Yu, Xiaoyang; Sun, Xiaoming; Wu, Haibin

    2016-09-01

    Combination of Gray code and phase-shifting is the most practical and advanced approach for the structured light 3-D measurement so far, which is able to measure objects with complex and discontinuous surface. However, for the traditional combination of the Gray code and phase-shifting, the captured Gray code images are not always sharp cut-off in the black-white conversion boundaries, which may lead to wrong decoding analog code orders. Moreover, during the actual measurement, there also exists local decoding error for the wrapped analog code obtained with the phase-shifting approach. Therefore, for the traditional approach, the wrong analog code orders and the local decoding errors will consequently introduce the errors which are equivalent to a fringe period when the analog code is unwrapped. In order to avoid one-fringe period errors, we propose an approach which combines Gray code with phase-shifting according to unequal period. With theoretical analysis, we build the measurement model of the proposed approach, determine the applicable condition and optimize the Gray code encoding period and phase-shifting fringe period. The experimental results verify that the proposed approach can offer a reliable unwrapped analog code, which can be used in 3-D shape measurement.

  7. 1/f noise measurements for faster evaluation of electromigration in advanced microelectronics interconnections

    NASA Astrophysics Data System (ADS)

    Beyne, Sofie; Croes, Kristof; De Wolf, Ingrid; Tőkei, Zsolt

    2016-05-01

    The use of 1/f noise measurements is explored for the purpose of finding faster techniques for electromigration (EM) characterization in advanced microelectronic interconnects, which also enable a better understanding of its underlying physical mechanisms. Three different applications of 1/f noise for EM characterization are explored. First, whether 1/f noise measurements during EM stress can serve as an early indicator of EM damage. Second, whether the current dependence of the noise power spectral density (PSD) can be used for a qualitative comparison of the defect concentration of different interconnects and consequently also their EM lifetime t50. Third, whether the activation energies obtained from the temperature dependence of the 1/f noise PSD correspond to the activation energies found by means of classic EM tests. In this paper, the 1/f noise technique has been used to assess and compare the EM properties of various advanced integration schemes and different materials, as they are being explored by the industry to enable advanced interconnect scaling. More concrete, different types of copper interconnects and one type of tungsten interconnect are compared. The 1/f noise measurements confirm the excellent electromigration properties of tungsten and demonstrate a dependence of the EM failure mechanism on copper grain size and distribution, where grain boundary diffusion is found to be a dominant failure mechanism.

  8. AISI/DOE Advanced Process Control Program Vol. 6 of 6: Temperature Measurement of Galvanneal Steel

    SciTech Connect

    S.W. Allison; D.L. Beshears; W.W. Manges

    1999-06-30

    This report describes the successful completion of the development of an accurate in-process measurement instrument for galvanneal steel surface temperatures. This achievement results from a joint research effort that is a part of the American Iron and Steel Institute's (AISI) Advanced Process Control Program, a collaboration between the U.S> Department of Energy and fifteen North American Steelmakers. This three-year project entitled ''Temperature Measurement of Galvanneal Steel'' uses phosphor thermography, and outgrowth of Uranium enrichment research at Oak Ridge facilities. Temperature is the controlling factor regarding the distribution of iron and zinc in the galvanneal strip coating, which in turn determines the desired product properties

  9. A Multifaceted Approach to Modernizing NASA's Advanced Multi-Mission Operations System (AMMOS) System Architecture

    NASA Technical Reports Server (NTRS)

    Estefan, Jeff A.; Giovannoni, Brian J.

    2014-01-01

    The Advanced Multi-Mission Operations Systems (AMMOS) is NASA's premier space mission operations product line offering for use in deep-space robotic and astrophysics missions. The general approach to AMMOS modernization over the course of its 29-year history exemplifies a continual, evolutionary approach with periods of sponsor investment peaks and valleys in between. Today, the Multimission Ground Systems and Services (MGSS) office-the program office that manages the AMMOS for NASA-actively pursues modernization initiatives and continues to evolve the AMMOS by incorporating enhanced capabilities and newer technologies into its end-user tool and service offerings. Despite the myriad of modernization investments that have been made over the evolutionary course of the AMMOS, pain points remain. These pain points, based on interviews with numerous flight project mission operations personnel, can be classified principally into two major categories: 1) information-related issues, and 2) process-related issues. By information-related issues, we mean pain points associated with the management and flow of MOS data across the various system interfaces. By process-related issues, we mean pain points associated with the MOS activities performed by mission operators (i.e., humans) and supporting software infrastructure used in support of those activities. In this paper, three foundational concepts-Timeline, Closed Loop Control, and Separation of Concerns-collectively form the basis for expressing a set of core architectural tenets that provides a multifaceted approach to AMMOS system architecture modernization intended to address the information- and process-related issues. Each of these architectural tenets will be further explored in this paper. Ultimately, we envision the application of these core tenets resulting in a unified vision of a future-state architecture for the AMMOS-one that is intended to result in a highly adaptable, highly efficient, and highly cost

  10. Advances in peripheral nervous system regenerative therapeutic strategies: A biomaterials approach.

    PubMed

    Dalamagkas, Kyriakos; Tsintou, Magdalini; Seifalian, Alexander

    2016-08-01

    Peripheral nerve injury is a very common medical condition with varying clinical severity but always great impact on the patients' productivity and the quality of life. Even the current 1st-choice surgical therapeutic approach or the "gold standard" as frequently called in clinical practice, is not addressing the problem efficiently and cost-effectively, increasing the mortality through the need of a second surgical intervention, while it does not take into account the several different types of nerves involved in peripheral nerve injuries. Neural tissue engineering approaches could potentially offer a very promising and attractive tool for the efficient peripheral nerve injury management, not only by mechanically building the gap, but also by inducing neuroregenerative mechanisms in a well-regulated microenvironment which would mimic the natural environment of the specific nerve type involved in the injury to obtain an optimum clinical outcome. There is still room for a lot of optimizations in regard to the conduits which have been developed with the help of neural engineering since many parameters affect the clinical outcome and the underlying mechanisms are still not well understood. Especially the intraluminal cues controlling the microenvironment of the conduits are in an infantile stage but there is profound potential in the application of the scaffolds. The aim of our review is to provide a quick reference to the recent advances in the field, focusing on the parameters that can significantly affect the clinical potentials of each approach, with suggestions for future improvements that could take the current work from bench to bedside. Thus, further research could shed light to those questions and it might hold the key to discover new more efficient and cost-effective therapies.

  11. An approach for the accurate measurement of social morality levels.

    PubMed

    Liu, Haiyan; Chen, Xia; Zhang, Bo

    2013-01-01

    In the social sciences, computer-based modeling has become an increasingly important tool receiving widespread attention. However, the derivation of the quantitative relationships linking individual moral behavior and social morality levels, so as to provide a useful basis for social policy-making, remains a challenge in the scholarly literature today. A quantitative measurement of morality from the perspective of complexity science constitutes an innovative attempt. Based on the NetLogo platform, this article examines the effect of various factors on social morality levels, using agents modeling moral behavior, immoral behavior, and a range of environmental social resources. Threshold values for the various parameters are obtained through sensitivity analysis; and practical solutions are proposed for reversing declines in social morality levels. The results show that: (1) Population size may accelerate or impede the speed with which immoral behavior comes to determine the overall level of social morality, but it has no effect on the level of social morality itself; (2) The impact of rewards and punishment on social morality levels follows the "5∶1 rewards-to-punishment rule," which is to say that 5 units of rewards have the same effect as 1 unit of punishment; (3) The abundance of public resources is inversely related to the level of social morality; (4) When the cost of population mobility reaches 10% of the total energy level, immoral behavior begins to be suppressed (i.e. the 1/10 moral cost rule). The research approach and methods presented in this paper successfully address the difficulties involved in measuring social morality levels, and promise extensive application potentials.

  12. An Approach for the Accurate Measurement of Social Morality Levels

    PubMed Central

    Liu, Haiyan; Chen, Xia; Zhang, Bo

    2013-01-01

    In the social sciences, computer-based modeling has become an increasingly important tool receiving widespread attention. However, the derivation of the quantitative relationships linking individual moral behavior and social morality levels, so as to provide a useful basis for social policy-making, remains a challenge in the scholarly literature today. A quantitative measurement of morality from the perspective of complexity science constitutes an innovative attempt. Based on the NetLogo platform, this article examines the effect of various factors on social morality levels, using agents modeling moral behavior, immoral behavior, and a range of environmental social resources. Threshold values for the various parameters are obtained through sensitivity analysis; and practical solutions are proposed for reversing declines in social morality levels. The results show that: (1) Population size may accelerate or impede the speed with which immoral behavior comes to determine the overall level of social morality, but it has no effect on the level of social morality itself; (2) The impact of rewards and punishment on social morality levels follows the “5∶1 rewards-to-punishment rule,” which is to say that 5 units of rewards have the same effect as 1 unit of punishment; (3) The abundance of public resources is inversely related to the level of social morality; (4) When the cost of population mobility reaches 10% of the total energy level, immoral behavior begins to be suppressed (i.e. the 1/10 moral cost rule). The research approach and methods presented in this paper successfully address the difficulties involved in measuring social morality levels, and promise extensive application potentials. PMID:24312189

  13. Advanced near-and mid-infrared laser based instruments for atmospheric measurements

    NASA Astrophysics Data System (ADS)

    Richter, Dirk; Weibring, Petter; Spuler, Scott; Walega, James; Spowart, Mike; Fried, Alan

    2010-05-01

    We present new ground and airborne instruments for atmospheric measurements based on fiber and diode laser sources. This versatile optical technology can be configured to provide high resolution, sensitive, selective, and real-time measurements. In particular we will present current and planned instruments to measure important trace gas species, including isotopes, and 3D wind-speeds from an aircraft platform. All the instruments presented leverage technology advances made in the photonics and optical telecommunication industry. We have developed a set of tools based around these technological building blocks and used them to design a suite of measurement capabilities for use by the atmospheric research community. Optical technologies have been accumulating a proven record of robust performance, and enable one to built more lightweight and compact instrumentation for easy deployment for traditional ground, advanced sea, and airborne measurement platforms. We will present how these enabling optical technologies have served as the foundation for select instruments, and provide a roadmap for future development opportunities.

  14. Comet assay to measure DNA repair: approach and applications

    PubMed Central

    Azqueta, Amaya; Slyskova, Jana; Langie, Sabine A. S.; O’Neill Gaivão, Isabel; Collins, Andrew

    2014-01-01

    Cellular repair enzymes remove virtually all DNA damage before it is fixed; repair therefore plays a crucial role in preventing cancer. Repair studied at the level of transcription correlates poorly with enzyme activity, and so assays of phenotype are needed. In a biochemical approach, substrate nucleoids containing specific DNA lesions are incubated with cell extract; repair enzymes in the extract induce breaks at damage sites; and the breaks are measured with the comet assay. The nature of the substrate lesions defines the repair pathway to be studied. This in vitro DNA repair assay has been modified for use in animal tissues, specifically to study the effects of aging and nutritional intervention on repair. Recently, the assay was applied to different strains of Drosophila melanogaster proficient and deficient in DNA repair. Most applications of the repair assay have been in human biomonitoring. Individual DNA repair activity may be a marker of cancer susceptibility; alternatively, high repair activity may result from induction of repair enzymes by exposure to DNA-damaging agents. Studies to date have examined effects of environment, nutrition, lifestyle, and occupation, in addition to clinical investigations. PMID:25202323

  15. Comet assay to measure DNA repair: approach and applications.

    PubMed

    Azqueta, Amaya; Slyskova, Jana; Langie, Sabine A S; O'Neill Gaivão, Isabel; Collins, Andrew

    2014-01-01

    Cellular repair enzymes remove virtually all DNA damage before it is fixed; repair therefore plays a crucial role in preventing cancer. Repair studied at the level of transcription correlates poorly with enzyme activity, and so assays of phenotype are needed. In a biochemical approach, substrate nucleoids containing specific DNA lesions are incubated with cell extract; repair enzymes in the extract induce breaks at damage sites; and the breaks are measured with the comet assay. The nature of the substrate lesions defines the repair pathway to be studied. This in vitro DNA repair assay has been modified for use in animal tissues, specifically to study the effects of aging and nutritional intervention on repair. Recently, the assay was applied to different strains of Drosophila melanogaster proficient and deficient in DNA repair. Most applications of the repair assay have been in human biomonitoring. Individual DNA repair activity may be a marker of cancer susceptibility; alternatively, high repair activity may result from induction of repair enzymes by exposure to DNA-damaging agents. Studies to date have examined effects of environment, nutrition, lifestyle, and occupation, in addition to clinical investigations.

  16. Measures of Adequacy for Library Collections in Australian Colleges of Advanced Education. Report of a Research Project Conducted in Behalf of the Commission on Advanced Education. Volume 1.

    ERIC Educational Resources Information Center

    Wainwright, E. J.; Dean, J. E.

    This study investigates the bases for constructing quantitative and qualitative measures of Australian Colleges of Advanced Education (CAE) library collection adequacy, and the feasibility of producing specialized and appropriate measures to guide future collection planning. Adequacy is based on the libraries' policies for providing materials to…

  17. Final Report for SERDP Project RC-1649: Advanced Chemical Measurements of Smoke from DoD-prescribed Burns

    SciTech Connect

    Johnson, Timothy J.; Weise, David; Lincoln, E. N.; Sams, Robert L.; Cameron, Melanie; Veres, Patrick; Yokelson, Robert J.; Urbanski, Shawn; Profeta, Luisa T.; Williams, S.; Gilman, Jessica; Kuster, W. C.; Akagi, Sheryl; Stockwell, Chelsea E.; Mendoza, Albert; Wold, Cyle E.; Warneke, Carsten; de Gouw, Joost A.; Burling, Ian R.; Reardon, James; Schneider, Matthew D.; Griffith, David WT; Roberts, James M.

    2013-12-17

    Objectives: Project RC-1649, “Advanced Chemical Measurement of Smoke from DoD-prescribed Burns” was undertaken to use advanced instrumental techniques to study in detail the particulate and vapor-phase chemical composition of the smoke that results from prescribed fires used as a land management tool on DoD bases, particularly bases in the southeastern U.S. The statement of need (SON) called for “(1) improving characterization of fuel consumption” and “(2) improving characterization of air emissions under both flaming and smoldering conditions with respect to volatile organic compounds, heavy metals, and reactive gases.” The measurements and fuels were from several bases throughout the southeast (Camp Lejeune, Ft. Benning, and Ft. Jackson) and were carried out in collaboration and conjunction with projects 1647 (models) and 1648 (particulates, SW bases). Technical Approach: We used an approach that featured developing techniques for measuring biomass burning emission species in both the laboratory and field and developing infrared (IR) spectroscopy in particular. Using IR spectroscopy and other methods, we developed emission factors (EF, g of effluent per kg of fuel burned) for dozens of chemical species for several common southeastern fuel types. The major measurement campaigns were laboratory studies at the Missoula Fire Sciences Laboratory (FSL) as well as field campaigns at Camp Lejeune, NC, Ft. Jackson, SC, and in conjunction with 1648 at Vandenberg AFB, and Ft. Huachuca. Comparisons and fusions of laboratory and field data were also carried out, using laboratory fuels from the same bases. Results: The project enabled new technologies and furthered basic science, mostly in the area of infrared spectroscopy, a broadband method well suited to biomass burn studies. Advances in hardware, software and supporting reference data realized a nearly 20x improvement in sensitivity and now provide quantitative IR spectra for potential detection of ~60 new

  18. An aggregate modeling and measurement approach for power estimation of through-the-wall target returns

    NASA Astrophysics Data System (ADS)

    Thajudeen, Christopher; Hoorfar, Ahmad; Ahmad, Fauzia; Dogaru, Traian

    2010-04-01

    With recent advances in both algorithm and component technologies, through-the-wall sensing and imaging is emerging as an affordable sensor technology in civilian and military settings. One of the primary objectives of through-the-wall sensing systems is to detect and identify targets of interest, such as humans and cache of weapons, enclosed in building structures. Effective approaches that achieve proper target radar cross section (RCS) registration behind walls must, in general, exploit a detailed understanding of the radar phenomenology and more specifically, knowledge of the expected strength of the radar return from targets of interest. In this paper, we investigate the effects of various wall types on the received power of the target return through the use of a combined measurement and electromagnetic modeling approach. The RCS of material-exact rifle and human models are investigated in free-space using numerical electromagnetic modeling tools. A modified radar range equation, which analytically accounts for the wall effects, including multiple reflections within a given homogeneous or layered wall, is then employed in conjunction with wideband measured parameters of various common wall types, to estimate the received power versus frequency from the aforementioned targets. The proposed technique is, in principle, applicable to both bistatic and mono-static operations.

  19. Examining single-source secondary impacts estimated from brute-force, decoupled direct method, and advanced plume treatment approaches

    NASA Astrophysics Data System (ADS)

    Kelly, James T.; Baker, Kirk R.; Napelenok, Sergey L.; Roselle, Shawn J.

    2015-06-01

    In regulatory assessments, there is a need for reliable estimates of the impacts of precursor emissions from individual sources on secondary PM2.5 (particulate matter with aerodynamic diameter less than 2.5 microns) and ozone. Three potential methods for estimating these impacts using Eulerian grid photochemical models are the brute-force (B-F) method, the decoupled direct method (DDM), and advanced plume treatment (APT). Here, we systematically inter-compare and assess the B-F, DDM, and APT approaches using hypothetical sources in a consistent modeling platform for a wide range of source conditions (i.e., emissions amount and composition, location within two California air basins, and stack parameters). The impacts of NOx and VOC sources on ozone and SO2 sources on PM2.5 sulfate calculated by these methods are in general agreement. The agreement is evident in the similar magnitudes, spatial patterns, and strong correlations among the impacts. This result, along with previous model evaluations based on similar Eulerian grid modeling, builds confidence in the reliability of the impact estimates. Disagreement among methods is evident in calculations of PM2.5 nitrate impacts associated with NH3 and NOx sources. Numerical instabilities in DDM sensitivity calculations compromise the nitrate impact estimates from that approach. The B-F and APT methods, which use brute-force differencing to identify impacts, are affected by numerical artifacts to a lesser degree than (H)DDM, with the artifacts being more prominent for APT than B-F. Overall, our results indicate that the (H)DDM, B-F, and APT approaches are viable for use in estimating single-source impacts for ozone and secondary PM2.5 sulfate, while the B-F method appears to be the most reliable for estimating nitrate impacts. There is a need for additional field study measurements to better constrain model estimates of single-source secondary impacts.

  20. Development of an integrated energetic neutral particle measurement system on experimental advanced full superconducting tokamak

    SciTech Connect

    Zhu, Y. B. Liu, D.; Heidbrink, W. W.; Zhang, J. Z.; Qi, M. Z.; Xia, S. B.; Wan, B. N.; Li, J. G.

    2014-11-15

    Full function integrated, compact silicon photodiode based solid state neutral particle analyzers (ssNPA) have been developed for energetic particle (EP) relevant studies on the Experimental Advanced Superconducting Tokamak (EAST). The ssNPAs will be mostly operated in advanced current mode with a few channels to be operated in conventional pulse-counting mode, aiming to simultaneously achieve individually proved ultra-fast temporal, spatial, and spectral resolution capabilities. The design details together with considerations on EAST specific engineering realities and physics requirements are presented. The system, including a group of single detectors on two vertical ports and two 16-channel arrays on a horizontal port, can provide both active and passive charge exchange measurements. ssNPA detectors, with variable thickness of ultra thin tungsten dominated foils directly deposited on the front surface, are specially fabricated and utilized to achieve about 22 keV energy resolution for deuterium particle detection.

  1. Development of an integrated energetic neutral particle measurement system on experimental advanced full superconducting tokamak

    NASA Astrophysics Data System (ADS)

    Zhu, Y. B.; Zhang, J. Z.; Qi, M. Z.; Xia, S. B.; Liu, D.; Heidbrink, W. W.; Wan, B. N.; Li, J. G.

    2014-11-01

    Full function integrated, compact silicon photodiode based solid state neutral particle analyzers (ssNPA) have been developed for energetic particle (EP) relevant studies on the Experimental Advanced Superconducting Tokamak (EAST). The ssNPAs will be mostly operated in advanced current mode with a few channels to be operated in conventional pulse-counting mode, aiming to simultaneously achieve individually proved ultra-fast temporal, spatial, and spectral resolution capabilities. The design details together with considerations on EAST specific engineering realities and physics requirements are presented. The system, including a group of single detectors on two vertical ports and two 16-channel arrays on a horizontal port, can provide both active and passive charge exchange measurements. ssNPA detectors, with variable thickness of ultra thin tungsten dominated foils directly deposited on the front surface, are specially fabricated and utilized to achieve about 22 keV energy resolution for deuterium particle detection.

  2. Development of an integrated energetic neutral particle measurement system on experimental advanced full superconducting tokamak.

    PubMed

    Zhu, Y B; Zhang, J Z; Qi, M Z; Xia, S B; Liu, D; Heidbrink, W W; Wan, B N; Li, J G

    2014-11-01

    Full function integrated, compact silicon photodiode based solid state neutral particle analyzers (ssNPA) have been developed for energetic particle (EP) relevant studies on the Experimental Advanced Superconducting Tokamak (EAST). The ssNPAs will be mostly operated in advanced current mode with a few channels to be operated in conventional pulse-counting mode, aiming to simultaneously achieve individually proved ultra-fast temporal, spatial, and spectral resolution capabilities. The design details together with considerations on EAST specific engineering realities and physics requirements are presented. The system, including a group of single detectors on two vertical ports and two 16-channel arrays on a horizontal port, can provide both active and passive charge exchange measurements. ssNPA detectors, with variable thickness of ultra thin tungsten dominated foils directly deposited on the front surface, are specially fabricated and utilized to achieve about 22 keV energy resolution for deuterium particle detection.

  3. Gravitational Radiation from Binary Black Holes: Advances in the Perturbative Approach

    NASA Astrophysics Data System (ADS)

    Lousto, C. O.

    2005-08-01

    meeting in the Albert Einstein Institute in Germany http://www.aei-potsdam.mpg.de/~lousto/CAPRA/Capra4.html/. In 2002 Capra 5 was held in Pennsylvania http://cgwp.gravity.psu.edu/events/Capra5/capra5-BKP_2002-05-24-1200.shtml, and in 2003 the venue for Capra 6 was Kyoto, Japan http://www2.yukawa.kyoto-u.ac.jp/~misao/capra6/html/. Continuing with the tradition of the meeting taking place in the US on alternate years, I organized the 7th Capra meeting in Brownsville, Texas http://cgwa.phys.utb.edu/Events/agendaView.php?EventID=3 in 2004. This year, the 8th Capra meeting will be in Oxford, UK http://www.sstd.rl.ac.uk/capra/Index.htm. This volume contains contributions describing the current state of the field and topical areas of interest. It also contains some reviews of the advances made since 1997 and, most interesting to the readers, it describes the open problems and future lines of research in the field. The contributions have been divided into four logical groups. Part I is a collection of papers that deal with first-order perturbation theory. They contain a brief summary of the metric and curvature approaches to perturbations in terms of waveforms and the reconstruction of the metric perturbations in preparation for the computation of the self-force. This section also reviews the energy-momentum balance approach that makes use of the information about the radiation emitted to first perturbative order to correct the trajectory of the particle. Part II comprises works reviewing and expanding the formalism of the self-force. It reviews the newest description in terms of the regular and singular parts of the fields, replacing the original description in terms of tail and divergent parts. Part III contains several examples of application of the self-force formulae, from scalar to gravitational fields and from post-Newtonian expansions to matched expansions. Finally, part IV introduces the problem of computing second-order perturbations of the gravitational field, assuming

  4. A Combined Approach to Measure Micropollutant Behaviour during Riverbank Filtration

    NASA Astrophysics Data System (ADS)

    van Driezum, Inge; Saracevic, Ernis; Derx, Julia; Kirschner, Alexander; Sommer, Regina; Farnleitner, Andreas; Blaschke, Alfred Paul

    2016-04-01

    Riverbank filtration (RBF) systems are widely used as natural treatment process. The advantages of RBF over surface water abstraction are the elimination of for example suspended solids, biodegradable compounds (like specific micropollutants), bacteria and viruses (Hiscock and Grischek, 2002). However, in contrast to its importance, remarkably less is known on the respective external (e.g. industrial or municipal sewage) and the internal (e.g. wildlife and agricultural influence) sources of contaminants, the environmental availability and fate of the various hazardous substances, and its potential transport during soil and aquifer passage. The goal of this study is to get an insight in the behaviour of various micropollutants and microbial indicators during riverbank filtration. Field measurements were combined with numerical modelling approaches. The study area comprises an alluvial backwater and floodplain area downstream of Vienna. The river is highly dynamic, with discharges ranging from 900 m3/s during low flow to 11000 m3/s during flood events. Samples were taken in several monitoring wells along a transect extending from the river towards a backwater river in the floodplain. Three of the piezometers were situated in the first 20 meters away from the river in order to obtain information about micropollutant behaviour close to the river. A total of 9 different micropollutants were analysed in grab samples taken under different river flow conditions (n=33). Following enrichment using SPE, analysis was performed using high performance liquid chromatography-tandem mass spectrometry. Faecal indicators (E. coli and enterococci) and bacterial spores were enumerated in sample volumes of 1 L each using cultivation based methods (ISO 16649-1, ISO 7899-2:2000 and ISO 6222). The analysis showed that some compounds, e.g. ibuprofen and diclofenac, were only found in the river. These compounds were already degraded in the first ten meters away from the river. Analysis of

  5. Measuring Early Childhood Health and Health Disparities: A New Approach

    PubMed Central

    Hillemeier, Marianne M.; Lanza, Stephanie T.; Landale, Nancy S.; Oropesa, R. S.

    2012-01-01

    Objective Efforts to improve the health of U.S. children and reduce disparities have been hampered by lack of a rigorous way to summarize the multi-dimensional nature of children’s health. This research employed a novel statistical approach to measurement to provide an integrated, comprehensive perspective on early childhood health and disparities. Methods Nationally-representative data (n=8,800) came from the Early Childhood Longitudinal Study, Birth Cohort. Latent class analysis (LCA) was used to classify health at 48 months, incorporating health conditions, functioning, and aspects of physical, cognitive, and emotional development. Health disparities by gender, poverty, race/ethnicity, and birthweight were examined. Results Over half of all children were classified as healthy using multidimensional latent class methodology; others fell into one of seven less optimal health statuses. The analyses highlighted pervasive disparities in health, with poor children at increased risk of being classified into the most disadvantaged health status consisting of chronic conditions and a cluster of developmental problems including low cognitive achievement, poor social skills, and behavior problems. Children with very low birthweight had the highest rate of being in the most disadvantaged health status (25.2%), but moderately low birthweight children were also at elevated risk (7.9% versus 3.4% among non-low birthweight children). Conclusions Latent class analysis provides a uniquely comprehensive picture of child health and health disparities that identifies clusters of problems experienced by some groups. The findings underscore the importance of continued efforts to reduce preterm birth, and to ameliorate poverty’s effects on children’s health through access to high-quality healthcare and other services. PMID:23225206

  6. A New Approach in Advance Network Reservation and Provisioning for High-Performance Scientific Data Transfers

    SciTech Connect

    Balman, Mehmet; Chaniotakis, Evangelos; Shoshani, Arie; Sim, Alex

    2010-01-28

    Scientific applications already generate many terabytes and even petabytes of data from supercomputer runs and large-scale experiments. The need for transferring data chunks of ever-increasing sizes through the network shows no sign of abating. Hence, we need high-bandwidth high speed networks such as ESnet (Energy Sciences Network). Network reservation systems, i.e. ESnet's OSCARS (On-demand Secure Circuits and Advance Reservation System) establish guaranteed bandwidth of secure virtual circuits at a certain time, for a certain bandwidth and length of time. OSCARS checks network availability and capacity for the specified period of time, and allocates requested bandwidth for that user if it is available. If the requested reservation cannot be granted, no further suggestion is returned back to the user. Further, there is no possibility from the users view-point to make an optimal choice. We report a new algorithm, where the user specifies the total volume that needs to be transferred, a maximum bandwidth that he/she can use, and a desired time period within which the transfer should be done. The algorithm can find alternate allocation possibilities, including earliest time for completion, or shortest transfer duration - leaving the choice to the user. We present a novel approach for path finding in time-dependent networks, and a new polynomial algorithm to find possible reservation options according to given constraints. We have implemented our algorithm for testing and incorporation into a future version of ESnet?s OSCARS. Our approach provides a basis for provisioning end-to-end high performance data transfers over storage and network resources.

  7. Energy Therapies in Advanced Practice Oncology: An Evidence-Informed Practice Approach

    PubMed Central

    Potter, Pamela J.

    2013-01-01

    Advanced practitioners in oncology want patients to receive state-of-the-art care and support for their healing process. Evidence-informed practice (EIP), an approach to evaluating evidence for clinical practice, considers the varieties of evidence in the context of patient preference and condition as well as practitioner knowledge and experience. This article offers an EIP approach to energy therapies, namely, Therapeutic Touch (TT), Healing Touch (HT), and Reiki, as supportive interventions in cancer care; a description of the author’s professional experience with TT, HT, and Reiki in practice and research; an overview of the three energy healing modalities; a review of nine clinical studies related to oncology; and recommendations for EIP. These studies demonstrate a response to previous research design critiques. Findings indicate a positive benefit for oncology patients in the realms of pain, quality of life, fatigue, health function, and mood. Directionality of healing in immune response and cell line studies affirms the usual explanation that these therapies bring harmony and balance to the system in the direction of health. Foremost, the research literature demonstrates the safety of these therapies. In order to consider the varieties of evidence for TT, HT, and Reiki, EIP requires a qualitative examination of patient experiences with these modalities, exploration of where these modalities have been integrated into cancer care and how the practice works in the oncology setting, and discovery of the impact of implementation on provider practice and self-care. Next steps toward EIP require fleshing out the experience of these modalities by patients and health-care providers in the oncology care setting. PMID:25031994

  8. Energy therapies in advanced practice oncology: an evidence-informed practice approach.

    PubMed

    Potter, Pamela J

    2013-05-01

    Advanced practitioners in oncology want patients to receive state-of-the-art care and support for their healing process. Evidence-informed practice (EIP), an approach to evaluating evidence for clinical practice, considers the varieties of evidence in the context of patient preference and condition as well as practitioner knowledge and experience. This article offers an EIP approach to energy therapies, namely, Therapeutic Touch (TT), Healing Touch (HT), and Reiki, as supportive interventions in cancer care; a description of the author's professional experience with TT, HT, and Reiki in practice and research; an overview of the three energy healing modalities; a review of nine clinical studies related to oncology; and recommendations for EIP. These studies demonstrate a response to previous research design critiques. Findings indicate a positive benefit for oncology patients in the realms of pain, quality of life, fatigue, health function, and mood. Directionality of healing in immune response and cell line studies affirms the usual explanation that these therapies bring harmony and balance to the system in the direction of health. Foremost, the research literature demonstrates the safety of these therapies. In order to consider the varieties of evidence for TT, HT, and Reiki, EIP requires a qualitative examination of patient experiences with these modalities, exploration of where these modalities have been integrated into cancer care and how the practice works in the oncology setting, and discovery of the impact of implementation on provider practice and self-care. Next steps toward EIP require fleshing out the experience of these modalities by patients and health-care providers in the oncology care setting. PMID:25031994

  9. An Engineering Approach to Biomedical Sciences: Advanced Testing Methods and Pharmacokinetic Modeling

    PubMed Central

    Lamberti, Gaetano; Cascone, Sara; Titomanlio, Giuseppe

    2012-01-01

    In this paper, the philosophy of a research in pharmacology field, driven by an engineering approach, was described along with some case histories and examples. The improvement in the testing methods for pharmaceutical systems (in-vitro techniques), as well as the proposal and the testing of mathematical models to describe the pharmacokinetics (in-silico techniques) are reported with the aim of pointing out methodologies and tools able to reduce the need of expensive and ethical problematic in-vivo measurements. PMID:23905061

  10. The Management of Advanced Germ Cell Tumors in 2016: The Memorial Sloan Kettering Approach.

    PubMed

    Funt, Samuel A; Feldman, Darren R; Bosl, George J

    2016-07-01

    The high cure rate of patients with advanced germ cell tumors is the result of effective cisplatin-based chemotherapy; both previously untreated and relapsing patients can be cured. Risk stratification is particularly important in previously untreated patients. While retrospective salvage therapy analyses suggest that a number of clinical factors are associated with outcome, the appropriate selection of patients for, and the sequencing of, conventional- and high-dose regimens are subjects of debate because of the introduction of paclitaxel and different approaches to the administration of high-dose chemotherapy. This therapeutic landscape has been molded in part by our current understanding of treatment-associated toxicity. In this paper, we review the use of serum tumor markers in risk assignment and response evaluation; the treatment of previously untreated and relapsing patients; the role of surgical resection of residual disease, including retroperitoneal node dissection; and the importance of clinical trials for addressing unanswered questions and testing new therapies. Management controversies and possible future treatment enhancements that incorporate serum tumor marker decline and tumor genomics will also be discussed. PMID:27422113

  11. Advanced Pancreatic Cancer: Flourishing Novel Approaches in the Era of Biological Therapy

    PubMed Central

    Chiu, Joanne W.; Wong, Hilda; Leung, Roland; Pang, Roberta; Cheung, Tan-To; Fan, Sheung-Tat; Poon, Ronnie

    2014-01-01

    The progress in the development of systemic treatment for advanced pancreatic cancer (APC) has been slow. The mainstream treatment remains using chemotherapy including gemcitabine, FOLFIRINOX, and nab-paclitaxel. Erlotinib is the only approved biological therapy with marginal benefit. Studies of agents targeting epidermal growth factor receptor, angiogenesis, and RAS signaling have not been satisfying, and the usefulness of targeted therapy in APC is uncertain. Understanding in molecular processes and tumor biology has opened the door for new treatment strategies such as targeting insulin-like growth factor 1 receptor, transforming growth factor β, phosphoinositide 3-kinase/AKT/mammalian target of rapamycin pathway, and Notch pathway. New directions also include the upcoming immunotherapy and many novel agents that act on the microenvironment. The practice of personalized medicine using predictive biomarkers and pharmacogenomics signatures may also enhance the effectiveness of existing treatment. Future treatment approaches may involve comprehensive genomic assessment of tumor and integrated combinations of multiple agents to overcome treatment resistance. PMID:25117068

  12. Advanced pancreatic cancer: flourishing novel approaches in the era of biological therapy.

    PubMed

    Chiu, Joanne W; Wong, Hilda; Leung, Roland; Pang, Roberta; Cheung, Tan-To; Fan, Sheung-Tat; Poon, Ronnie; Yau, Thomas

    2014-09-01

    The progress in the development of systemic treatment for advanced pancreatic cancer (APC) has been slow. The mainstream treatment remains using chemotherapy including gemcitabine, FOLFIRINOX, and nab-paclitaxel. Erlotinib is the only approved biological therapy with marginal benefit. Studies of agents targeting epidermal growth factor receptor, angiogenesis, and RAS signaling have not been satisfying, and the usefulness of targeted therapy in APC is uncertain. Understanding in molecular processes and tumor biology has opened the door for new treatment strategies such as targeting insulin-like growth factor 1 receptor, transforming growth factor β, phosphoinositide 3-kinase/AKT/mammalian target of rapamycin pathway, and Notch pathway. New directions also include the upcoming immunotherapy and many novel agents that act on the microenvironment. The practice of personalized medicine using predictive biomarkers and pharmacogenomics signatures may also enhance the effectiveness of existing treatment. Future treatment approaches may involve comprehensive genomic assessment of tumor and integrated combinations of multiple agents to overcome treatment resistance. PMID:25117068

  13. Identifying contamination with advanced visualization and analysis practices: metagenomic approaches for eukaryotic genome assemblies

    PubMed Central

    Delmont, Tom O.

    2016-01-01

    High-throughput sequencing provides a fast and cost-effective mean to recover genomes of organisms from all domains of life. However, adequate curation of the assembly results against potential contamination of non-target organisms requires advanced bioinformatics approaches and practices. Here, we re-analyzed the sequencing data generated for the tardigrade Hypsibius dujardini, and created a holistic display of the eukaryotic genome assembly using DNA data originating from two groups and eleven sequencing libraries. By using bacterial single-copy genes, k-mer frequencies, and coverage values of scaffolds we could identify and characterize multiple near-complete bacterial genomes from the raw assembly, and curate a 182 Mbp draft genome for H. dujardini supported by RNA-Seq data. Our results indicate that most contaminant scaffolds were assembled from Moleculo long-read libraries, and most of these contaminants have differed between library preparations. Our re-analysis shows that visualization and curation of eukaryotic genome assemblies can benefit from tools designed to address the needs of today’s microbiologists, who are constantly challenged by the difficulties associated with the identification of distinct microbial genomes in complex environmental metagenomes. PMID:27069789

  14. Advancing data reuse in phyloinformatics using an ontology-driven Semantic Web approach.

    PubMed

    Panahiazar, Maryam; Sheth, Amit P; Ranabahu, Ajith; Vos, Rutger A; Leebens-Mack, Jim

    2013-01-01

    Phylogenetic analyses can resolve historical relationships among genes, organisms or higher taxa. Understanding such relationships can elucidate a wide range of biological phenomena, including, for example, the importance of gene and genome duplications in the evolution of gene function, the role of adaptation as a driver of diversification, or the evolutionary consequences of biogeographic shifts. Phyloinformaticists are developing data standards, databases and communication protocols (e.g. Application Programming Interfaces, APIs) to extend the accessibility of gene trees, species trees, and the metadata necessary to interpret these trees, thus enabling researchers across the life sciences to reuse phylogenetic knowledge. Specifically, Semantic Web technologies are being developed to make phylogenetic knowledge interpretable by web agents, thereby enabling intelligently automated, high-throughput reuse of results generated by phylogenetic research. This manuscript describes an ontology-driven, semantic problem-solving environment for phylogenetic analyses and introduces artefacts that can promote phyloinformatic efforts to promote accessibility of trees and underlying metadata. PhylOnt is an extensible ontology with concepts describing tree types and tree building methodologies including estimation methods, models and programs. In addition we present the PhylAnt platform for annotating scientific articles and NeXML files with PhylOnt concepts. The novelty of this work is the annotation of NeXML files and phylogenetic related documents with PhylOnt Ontology. This approach advances data reuse in phyloinformatics.

  15. Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy.

    PubMed

    Gong, Ting; Heng, Boon Chin; Lo, Edward Chin Man; Zhang, Chengfei

    2016-01-01

    Recent advances in biomaterial science and tissue engineering technology have greatly spurred the development of regenerative endodontics. This has led to a paradigm shift in endodontic treatment from simply filling the root canal systems with biologically inert materials to restoring the infected dental pulp with functional replacement tissues. Currently, cell transplantation has gained increasing attention as a scientifically valid method for dentin-pulp complex regeneration. This multidisciplinary approach which involves the interplay of three key elements of tissue engineering-stem cells, scaffolds, and signaling molecules-has produced an impressive number of favorable outcomes in preclinical animal studies. Nevertheless, many practical hurdles need to be overcome prior to its application in clinical settings. Apart from the potential health risks of immunological rejection and pathogenic transmission, the lack of a well-established banking system for the isolation and storage of dental-derived stem cells is the most pressing issue that awaits resolution and the properties of supportive scaffold materials vary across different studies and remain inconsistent. This review critically examines the classic triad of tissue engineering utilized in current regenerative endodontics and summarizes the possible techniques developed for dentin/pulp regeneration. PMID:27069484

  16. A Random-Model Approach to QTL Mapping in Multiparent Advanced Generation Intercross (MAGIC) Populations.

    PubMed

    Wei, Julong; Xu, Shizhong

    2016-02-01

    Most standard QTL mapping procedures apply to populations derived from the cross of two parents. QTL detected from such biparental populations are rarely relevant to breeding programs because of the narrow genetic basis: only two alleles are involved per locus. To improve the generality and applicability of mapping results, QTL should be detected using populations initiated from multiple parents, such as the multiparent advanced generation intercross (MAGIC) populations. The greatest challenges of QTL mapping in MAGIC populations come from multiple founder alleles and control of the genetic background information. We developed a random-model methodology by treating the founder effects of each locus as random effects following a normal distribution with a locus-specific variance. We also fit a polygenic effect to the model to control the genetic background. To improve the statistical power for a scanned marker, we release the marker effect absorbed by the polygene back to the model. In contrast to the fixed-model approach, we estimate and test the variance of each locus and scan the entire genome one locus at a time using likelihood-ratio test statistics. Simulation studies showed that this method can increase statistical power and reduce type I error compared with composite interval mapping (CIM) and multiparent whole-genome average interval mapping (MPWGAIM). We demonstrated the method using a public Arabidopsis thaliana MAGIC population and a mouse MAGIC population.

  17. Advancing the 3Rs in regulatory ecotoxicology: A pragmatic cross-sector approach.

    PubMed

    Burden, Natalie; Benstead, Rachel; Clook, Mark; Doyle, Ian; Edwards, Peter; Maynard, Samuel K; Ryder, Kathryn; Sheahan, Dave; Whale, Graham; van Egmond, Roger; Wheeler, James R; Hutchinson, Thomas H

    2016-07-01

    The ecotoxicity testing of chemicals for prospective environmental safety assessment is an area in which a high number of vertebrates are used across a variety of industry sectors. Refining, reducing, and replacing the use of animals such as fish, birds, and amphibians for this purpose addresses the ethical concerns and the increasing legislative requirements to consider alternative test methods. Members of the UK-based National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) Ecotoxicology Working Group, consisting of representatives from academia, government organizations, and industry, have worked together over the past 6 y to provide evidence bases to support and advance the application of the 3Rs in regulatory ecotoxicity testing. The group recently held a workshop to identify the areas of testing, demands, and drivers that will have an impact on the future of animal use in regulatory ecotoxicology. As a result of these discussions, we have developed a pragmatic approach to prioritize and realistically address key opportunity areas, to enable progress toward the vision of a reduced reliance on the use of animals in this area of testing. This paper summarizes the findings of this exercise and proposes a pragmatic strategy toward our key long-term goals-the incorporation of reliable alternatives to whole-organism testing into regulations and guidance, and a culture shift toward reduced reliance on vertebrate toxicity testing in routine environmental safety assessment. Integr Environ Assess Manag 2016;12:417-421. © 2015 SETAC.

  18. Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy

    PubMed Central

    Gong, Ting; Heng, Boon Chin; Lo, Edward Chin Man; Zhang, Chengfei

    2016-01-01

    Recent advances in biomaterial science and tissue engineering technology have greatly spurred the development of regenerative endodontics. This has led to a paradigm shift in endodontic treatment from simply filling the root canal systems with biologically inert materials to restoring the infected dental pulp with functional replacement tissues. Currently, cell transplantation has gained increasing attention as a scientifically valid method for dentin-pulp complex regeneration. This multidisciplinary approach which involves the interplay of three key elements of tissue engineering—stem cells, scaffolds, and signaling molecules—has produced an impressive number of favorable outcomes in preclinical animal studies. Nevertheless, many practical hurdles need to be overcome prior to its application in clinical settings. Apart from the potential health risks of immunological rejection and pathogenic transmission, the lack of a well-established banking system for the isolation and storage of dental-derived stem cells is the most pressing issue that awaits resolution and the properties of supportive scaffold materials vary across different studies and remain inconsistent. This review critically examines the classic triad of tissue engineering utilized in current regenerative endodontics and summarizes the possible techniques developed for dentin/pulp regeneration. PMID:27069484

  19. Advancing data reuse in phyloinformatics using an ontology-driven Semantic Web approach

    PubMed Central

    2013-01-01

    Phylogenetic analyses can resolve historical relationships among genes, organisms or higher taxa. Understanding such relationships can elucidate a wide range of biological phenomena, including, for example, the importance of gene and genome duplications in the evolution of gene function, the role of adaptation as a driver of diversification, or the evolutionary consequences of biogeographic shifts. Phyloinformaticists are developing data standards, databases and communication protocols (e.g. Application Programming Interfaces, APIs) to extend the accessibility of gene trees, species trees, and the metadata necessary to interpret these trees, thus enabling researchers across the life sciences to reuse phylogenetic knowledge. Specifically, Semantic Web technologies are being developed to make phylogenetic knowledge interpretable by web agents, thereby enabling intelligently automated, high-throughput reuse of results generated by phylogenetic research. This manuscript describes an ontology-driven, semantic problem-solving environment for phylogenetic analyses and introduces artefacts that can promote phyloinformatic efforts to promote accessibility of trees and underlying metadata. PhylOnt is an extensible ontology with concepts describing tree types and tree building methodologies including estimation methods, models and programs. In addition we present the PhylAnt platform for annotating scientific articles and NeXML files with PhylOnt concepts. The novelty of this work is the annotation of NeXML files and phylogenetic related documents with PhylOnt Ontology. This approach advances data reuse in phyloinformatics. PMID:24565381

  20. Applications of Advanced Nondestructive Measurement Techniques to Address Safety of Flight Issues on NASA Spacecraft

    NASA Technical Reports Server (NTRS)

    Prosser, Bill

    2016-01-01

    Advanced nondestructive measurement techniques are critical for ensuring the reliability and safety of NASA spacecraft. Techniques such as infrared thermography, THz imaging, X-ray computed tomography and backscatter X-ray are used to detect indications of damage in spacecraft components and structures. Additionally, sensor and measurement systems are integrated into spacecraft to provide structural health monitoring to detect damaging events that occur during flight such as debris impacts during launch and assent or from micrometeoroid and orbital debris, or excessive loading due to anomalous flight conditions. A number of examples will be provided of how these nondestructive measurement techniques have been applied to resolve safety critical inspection concerns for the Space Shuttle, International Space Station (ISS), and a variety of launch vehicles and unmanned spacecraft.

  1. 77 FR 52977 - Regulatory Capital Rules: Advanced Approaches Risk-Based Capital Rule; Market Risk Capital Rule

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-30

    ...The Office of the Comptroller of the Currency (OCC), the Board of Governors of the Federal Reserve System (Board), and the Federal Deposit Insurance Corporation (FDIC) (collectively, the agencies) are seeking comment on three notices of proposed rulemaking (NPRs) that would revise and replace the agencies' current capital rules. In this NPR (Advanced Approaches and Market Risk NPR) the......

  2. Performance of an Advanced Stirling Convertor Based on Heat Flux Sensor Measurements

    NASA Technical Reports Server (NTRS)

    Wilson, Scott D.

    2012-01-01

    The U.S. Department of Energy (DOE) and Lockheed Martin Space Systems Company (LMSSC) have been developing the Advanced Stirling Radioisotope Generator (ASRG) for use as a power system for space science missions. This generator would use two high-efficiency Advanced Stirling Convertors (ASCs), developed by Sunpower, Inc., and NASA Glenn Research Center. The ASCs convert thermal energy from a radioisotope heat source into electricity. As part of ground testing of these ASCs, different operating conditions are used to simulate expected mission conditions. These conditions require achieving a particular operating frequency, hot-end and cold-end temperatures, and specified electrical power output for a given heat input. It is difficult to measure heat input to Stirling convertors due to the complex geometries of the hot components, temperature limits of sensor materials, and invasive integration of sensors. A thin-film heat flux sensor was used to directly measure heat input to an ASC. The effort succeeded in designing and fabricating unique sensors, which were integrated into a Stirling convertor ground test and exposed to test temperatures exceeding 700 C in air for 10,000 hr. Sensor measurements were used to calculate thermal efficiency for ASC-E (Engineering Unit) #1 and #4. The post-disassembly condition of the sensors is also discussed.

  3. Performance of an Advanced Stirling Convertor Based on Heat Flux Sensor Measurements

    NASA Technical Reports Server (NTRS)

    Wilson, Dcott D.

    2012-01-01

    The U.S. Department of Energy (DOE) and Lockheed Martin Space Systems Company (LMSSC) have been developing the Advanced Stirling Radioisotope Generator (ASRG) for use as a power system for space science missions. This generator would use two highefficiency Advanced Stirling Convertors (ASCs), developed by Sunpower, Inc., and NASA Glenn Research Center. The ASCs convert thermal energy from a radioisotope heat source into electricity. As part of ground testing of these ASCs, different operating conditions are used to simulate expected mission conditions. These conditions require achieving a particular operating frequency, hot-end and cold-end temperatures, and specified electrical power output for a given heat input. It is difficult to measure heat input to Stirling convertors due to the complex geometries of the hot components, temperature limits of sensor materials, and invasive integration of sensors. A thin-film heat flux sensor was used to directly measure heat input to an ASC. The effort succeeded in designing and fabricating unique sensors, which were integrated into a Stirling convertor ground test and exposed to test temperatures exceeding 700 C in air for 10,000 hr. Sensor measurements were used to calculate thermal efficiency for ASC-E (Engineering Unit) #1 and #4. The post-disassembly condition of the sensors is also discussed.

  4. Techniques for measurement of the thermal expansion of advanced composite materials

    NASA Technical Reports Server (NTRS)

    Tompkins, Stephen S.

    1989-01-01

    Techniques available to measure small thermal displacements in flat laminates and structural tubular elements of advanced composite materials are described. Emphasis is placed on laser interferometry and the laser interferometric dilatometer system used at the National Aeronautics and Space Administration (NASA) Langley Research Center. Thermal expansion data are presented for graphite-fiber reinforced 6061 and 2024 aluminum laminates and for graphite fiber reinforced AZ91 C and QH21 A magnesium laminates before and after processing to minimize or eliminate thermal strain hysteresis. Data are also presented on the effects of reinforcement volume content on thermal expansion of silicon-carbide whisker and particulate reinforced aluminum.

  5. Advanced Communications Technology Satellite (ACTS): Design and on-orbit performance measurements

    NASA Technical Reports Server (NTRS)

    Gargione, F.; Acosta, R.; Coney, T.; Krawczyk, R.

    1995-01-01

    The Advanced Communications Technology Satellite (ACTS), developed and built by Lockheed Martin Astro space for the NASA Lewis Research Center, was launched in September 1993 on the shuttle STS 51 mission. ACTS is a digital experimental communications test bed that incorporates gigahertz bandwidth transponders operating at Ka band, hopping spot beams, on-board storage and switching, and dynamic rain fade compensation. This paper describes the ACTS enabling technologies, the design of the communications payload, the constraints imposed on the spacecraft bus, and the measurements conducted to verify the performance of the system in orbit.

  6. Precision bone and muscle loss measurements by advanced, multiple projection DEXA (AMPDXA) techniques for spaceflight applications

    NASA Technical Reports Server (NTRS)

    Charles, H. K. Jr; Beck, T. J.; Feldmesser, H. S.; Magee, T. C.; Spisz, T. S.; Pisacane, V. L.

    2001-01-01

    An advanced, multiple projection, dual energy x-ray absorptiometry (AMPDXA) scanner system is under development. The AMPDXA is designed to make precision bone and muscle loss measurements necessary to determine the deleterious effects of microgravity on astronauts as well as develop countermeasures to stem their bone and muscle loss. To date, a full size test system has been developed to verify principles and the results of computer simulations. Results indicate that accurate predictions of bone mechanical properties can be determined from as few as three projections, while more projections are needed for a complete, three-dimensional reconstruction. c 2001. Elsevier Science Ltd. All rights reserved.

  7. The investigation of advanced remote sensing techniques for the measurement of aerosol characteristics

    NASA Technical Reports Server (NTRS)

    Deepak, A.; Becher, J.

    1979-01-01

    Advanced remote sensing techniques and inversion methods for the measurement of characteristics of aerosol and gaseous species in the atmosphere were investigated. Of particular interest were the physical and chemical properties of aerosols, such as their size distribution, number concentration, and complex refractive index, and the vertical distribution of these properties on a local as well as global scale. Remote sensing techniques for monitoring of tropospheric aerosols were developed as well as satellite monitoring of upper tropospheric and stratospheric aerosols. Computer programs were developed for solving multiple scattering and radiative transfer problems, as well as inversion/retrieval problems. A necessary aspect of these efforts was to develop models of aerosol properties.

  8. Advances in kinetic isotope effect measurement techniques for enzyme mechanism study.

    PubMed

    Gu, Hong; Zhang, Shuming

    2013-08-02

    Kinetic isotope effects (KIEs) are a very powerful tool for investigating enzyme mechanisms. Precision of measurement is the most important factor for KIE determinations, especially for small heavy atom KIEs. Internal competition is commonly used to measure small KIEs on V/K. Several methods, including such as liquid scintillation counting, mass spectrometry, nuclear magnetic resonance spectroscopy and polarimetry have been used to determine KIEs. In this paper, which does not aspire to be an exhaustive review, we briefly review different experimental approaches for the measurement of KIEs on enzymatic reaction with an emphasis on newer techniques employing mass spectrometry and nuclear magnetic resonance spectrometry as well as some corresponding examples.

  9. Palliative Surgical Approach in Advanced Nonresponsive Mucinous Ovarian Cancer: A Rare Case Report

    PubMed Central

    Agarwal, Manika; Kumar, Ritesh; Topno, Noor; Mishra, Shweta; Dhirasaria, Ashish; Singh, A Santa

    2016-01-01

    Advanced mucinous ovarian cancer is a separate entity and has different biological behaviour. There is a wide range of therapeutic challenges and dilemmas in the management of these patients. The authors present a case of advanced ovarian mucinous cystadenocarcinoma with pseudomyxoma peritonei who had poor response to standard neoadjuvant chemotherapy. This case is highlighted to emphasize the challenges in the decision making for the management of advanced mucinous ovarian cancer. PMID:27162429

  10. A Multi-Dimensional Approach to Measuring News Media Literacy

    ERIC Educational Resources Information Center

    Vraga, Emily; Tully, Melissa; Kotcher, John E.; Smithson, Anne-Bennett; Broeckelman-Post, Melissa

    2015-01-01

    Measuring news media literacy is important in order for it to thrive in a variety of educational and civic contexts. This research builds on existing measures of news media literacy and two new scales are presented that measure self-perceived media literacy (SPML) and perceptions of the value of media literacy (VML). Research with a larger sample…

  11. Integrated Multipoint-Laser Endoscopic Airway Measurements by Transoral Approach

    PubMed Central

    Neitsch, Marie; Horn, Iris-Susanne; Hofer, Mathias; Dietz, Andreas; Fischer, Miloš

    2016-01-01

    Objectives. Optical and technical characteristics usually do not allow objective endoscopic distance measurements. So far no standardized method for endoscopic distance measurement is available. The aim of this study was to evaluate the feasibility and accuracy of transoral airway measurements with a multipoint-laser endoscope. Methods. The semirigid endoscope includes a multipoint laser measurement system that projects 49 laser points (wavelength 639 nm, power < 5 mW) into the optical axis of the endoscopic view. Distances, areas, and depths can be measured in real-time. Transoral endoscopic airway measurements were performed on nine human cadavers, which were correlated with CT measurements. Results. The preliminary experiment showed an optimum distance between the endoscope tip and the object of 5 to 6 cm. There was a mean measurement error of 3.26% ± 2.53%. A Spearman correlation coefficient of 0.95 (p = 0.01) was calculated for the laryngeal measurements and of 0.93 (p < 0.01) for the tracheal measurements compared to the CT. Using the Bland-Altman-Plot, the 95% limits of agreement for the laryngeal measurements were satisfactory: −0.76 and 0.93. Conclusions. Integrated multipoint-laser endoscopic measurement is a promising technical supplement, with potential use in diagnostic endoscopy and transoral endoscopic surgery in daily practice. PMID:27022612

  12. Advancement of the Subchondral Bone Plate in Translational Models of Osteochondral Repair: Implications for Tissue Engineering Approaches.

    PubMed

    Orth, Patrick; Madry, Henning

    2015-12-01

    Subchondral bone plate advancement is of increasing relevance for translational models of osteochondral repair in tissue engineering (TE). Especially for therapeutic TE approaches, a basic scientific knowledge of its chronological sequence, possible etiopathogenesis, and clinical implications are indispensable. This review summarizes the knowledge on this topic gained from a total of 31 translational investigations, including 1009 small and large animals. Experimental data indicate that the advancement of the subchondral bone plate frequently occurs during the spontaneous repair of osteochondral defects and following established articular cartilage repair approaches for chondral lesions such as marrow stimulation and TE-based strategies such as autologous chondrocyte implantation. Importantly, this subchondral bone reaction proceeds in a defined chronological and spatial pattern, reflecting both endochondral ossification and intramembranous bone formation. Subchondral bone plate advancement arises earlier in small animals and defects, but is more pronounced at the long term in large animals. Possible etiopathologies comprise a disturbed subchondral bone/articular cartilage crosstalk and altered biomechanical conditions or neovascularization. Of note, no significant correlation was found so far between subchondral bone plate advancement and articular cartilage repair. This evidence from translational animal models adverts to an increasing awareness of this previously underestimated pathology. Future research will shed more light on the advancement of the subchondral bone plate in TE models of cartilage repair. PMID:26066580

  13. Advancement of the Subchondral Bone Plate in Translational Models of Osteochondral Repair: Implications for Tissue Engineering Approaches.

    PubMed

    Orth, Patrick; Madry, Henning

    2015-12-01

    Subchondral bone plate advancement is of increasing relevance for translational models of osteochondral repair in tissue engineering (TE). Especially for therapeutic TE approaches, a basic scientific knowledge of its chronological sequence, possible etiopathogenesis, and clinical implications are indispensable. This review summarizes the knowledge on this topic gained from a total of 31 translational investigations, including 1009 small and large animals. Experimental data indicate that the advancement of the subchondral bone plate frequently occurs during the spontaneous repair of osteochondral defects and following established articular cartilage repair approaches for chondral lesions such as marrow stimulation and TE-based strategies such as autologous chondrocyte implantation. Importantly, this subchondral bone reaction proceeds in a defined chronological and spatial pattern, reflecting both endochondral ossification and intramembranous bone formation. Subchondral bone plate advancement arises earlier in small animals and defects, but is more pronounced at the long term in large animals. Possible etiopathologies comprise a disturbed subchondral bone/articular cartilage crosstalk and altered biomechanical conditions or neovascularization. Of note, no significant correlation was found so far between subchondral bone plate advancement and articular cartilage repair. This evidence from translational animal models adverts to an increasing awareness of this previously underestimated pathology. Future research will shed more light on the advancement of the subchondral bone plate in TE models of cartilage repair.

  14. Accuracy Advances in Measuring Earth Emission Spectra for Weather and Climate

    NASA Astrophysics Data System (ADS)

    Revercomb, H. E.; Best, F. A.; Tobin, D. C.; Knuteson, R. O.; Taylor, J. K.; Gero, P.; Adler, D. P.; Pettersen, C.; Mulligan, M.

    2011-12-01

    Launch of the first component of the Joint Polar Satellite System (JPSS) in late October is expected to initiate a new series of US afternoon satellites to complement the EUMETSAT MetOp EPS morning observations. A key component is the Cross-track Infrared Sounder (CrIS) designed for advanced temperature and water vapor profiling for weather and climate applications. We have worked on getting this operational capability in space ever since conducting a Phase A instrument design in 1990, and will report on what is expected to be its highly accurate radiometric and spectral performance post launch. The expectation from thermal/vacuum testing is that the accuracy will exceed 0.2 K (k=3) brightness temperature at scene temperature for all three bands in the region from 3.5 to 15 microns. CrIS is expected to offer further confirmation of techniques that have proven to offer significant accuracy improvements for the new family of advanced sounding instruments including AIRS on NASA Aqua platform and IASI on MetOp A and that are needed in the new IR Decadal Survey measurements. CrIS and these other advanced sounders help set the stage for a new era in establishing spectrally resolved IR climate benchmark measurements from space. Here we report on being able to achieve even higher accuracy with instruments designed specifically for climate missions similar to the Decadal Survey Climate Absolute Radiance and Refractivity Observatory (CLARREO). Results will be presented from our NASA Instrument Incubator Program (IIP) effort for which a new concept for on-orbit verification and test has been developed. This system is capable of performing fundamental radiometric calibration, spectral characterization and calibration, and other key performance tests that are normally only performed prior to launch in thermal/vacuum testing. By verifying accuracy directly on-orbit, this capability should provide the ultra-high confidence in data sets needed for societal decision making.

  15. Treatment of real industrial wastewater using the combined approach of advanced oxidation followed by aerobic oxidation.

    PubMed

    Ramteke, Lokeshkumar P; Gogate, Parag R

    2016-05-01

    Fenton oxidation and ultrasound-based pretreatment have been applied to improve the treatment of real industrial wastewater based on the use of biological oxidation. The effect of operating parameters such as Fe(2+) loading, contact time, initial pH, and hydrogen peroxide loading on the extent of chemical oxygen demand (COD) reduction and change in biochemical oxygen demand (BOD5)/COD ratio has been investigated. The optimum operating conditions established for the pretreatment were initial pH of 3.0, Fe(2+) loading of 2.0, and 2.5 g L(-1) for the US/Fenton/stirring and Fenton approach, respectively, and temperature of 25 °C with initial H2O2 loading of 1.5 g L(-1). The use of pretreatment resulted in a significant increase in the BOD5/COD ratio confirming the production of easily digestible intermediates. The effect of the type of sludge in the aerobic biodegradation was also investigated based on the use of primary activated sludge (PAS), modified activated sludge (MAS), and activated sludge (AS). Enhanced removal of the pollutants as well as higher biomass yield was observed for MAS as compared to PAS and AS. The use of US/Fenton/stirring pretreatment under the optimized conditions followed by biological oxidation using MAS resulted in maximum COD removal at 97.9 %. The required hydraulic retention time for the combined oxidation system was also significantly lower as compared to only biological oxidation operation. Kinetic studies revealed that the reduction in the COD followed a first-order kinetic model for advanced oxidation and pseudo first-order model for biodegradation. The study clearly established the utility of the combined technology for the effective treatment of real industrial wastewater.

  16. Innovation Approaches to Development and Ground Testing of Advanced Bimodal Space Power and Propulsion Systems

    SciTech Connect

    Hill, T.; Noble, C.; Martinell, J.; Borowski, S.

    2000-07-14

    The last major development effort for nuclear power and propulsion systems ended in 1993. Currently, there is not an initiative at either the National Aeronautical and Space Administration (NASA) or the U.S. Department of Energy (DOE) that requires the development of new nuclear power and propulsion systems. Studies continue to show nuclear technology as a strong technical candidate to lead the way toward human exploration of adjacent planets or provide power for deep space missions, particularly a 15,000 lbf bimodal nuclear system with 115 kW power capability. The development of nuclear technology for space applications would require technology development in some areas and a major flight qualification program. The last major ground test facility considered for nuclear propulsion qualification was the U.S. Air Force/DOE Space Nuclear Thermal Propulsion Project. Seven years have passed since that effort, and the questions remain the same, how to qualify nuclear power and propulsion systems for future space flight. It can be reasonably assumed that much of the nuclear testing required to qualify a nuclear system for space application will be performed at DOE facilities as demonstrated by the Nuclear Rocket Engine Reactor Experiment (NERVA) and Space Nuclear Thermal Propulsion (SNTP) programs. The nuclear infrastructure to support testing in this country is aging and getting smaller, though facilities still exist to support many of the technology development needs. By renewing efforts, an innovative approach to qualifying these systems through the use of existing facilities either in the U.S. (DOE's Advance Test Reactor, High Flux Irradiation Facility and the Contained Test Facility) or overseas should be possible.

  17. Innovative Approaches to Development and Ground Testing of Advanced Bimodal Space Power and Propulsion Systems

    SciTech Connect

    Hill, Thomas Johnathan; Noble, Cheryl Ann; Noble, C.; Martinell, John Stephen; Borowski, S.

    2000-07-01

    The last major development effort for nuclear power and propulsion systems ended in 1993. Currently, there is not an initiative at either the National Aeronautical and Space Administration (NASA) or the U.S. Department of Energy (DOE) that requires the development of new nuclear power and propulsion systems. Studies continue to show nuclear technology as a strong technical candidate to lead the way toward human exploration of adjacent planets or provide power for deep space missions, particularly a 15,000 lbf bimodal nuclear system with 115 kW power capability. The development of nuclear technology for space applications would require technology development in some areas and a major flight qualification program. The last major ground test facility considered for nuclear propulsion qualification was the U.S. Air Force/DOE Space Nuclear Thermal Propulsion Project. Seven years have passed since that effort, and the questions remain the same, how to qualify nuclear power and propulsion systems for future space flight. It can be reasonable assumed that much of the nuclear testing required to qualify a nuclear system for space application will be performed at DOE facilities as demonstrated by the Nuclear Rocket Engine Reactor Experiment (NERVA) and Space Nuclear Thermal Propulsion (SNTP) programs. The nuclear infrastructure to support testing in this country is aging and getting smaller, though facilities still exist to support many of the technology development needs. By renewing efforts, an innovative approach to qualifying these systems through the use of existing facilities either in the U.S. (DOE's Advance Test Reactor, High Flux Irradiation Facility and the Contained Test Facility) or overseas should be possible.

  18. Advanced Nuclear Measurements - Sensitivity Analysis Emerging Safeguards, Problems and Proliferation Risk

    SciTech Connect

    Dreicer, J.S.

    1999-07-15

    During the past year this component of the Advanced Nuclear Measurements LDRD-DR has focused on emerging safeguards problems and proliferation risk by investigating problems in two domains. The first is related to the analysis, quantification, and characterization of existing inventories of fissile materials, in particular, the minor actinides (MA) formed in the commercial fuel cycle. Understanding material forms and quantities helps identify and define future measurement problems, instrument requirements, and assists in prioritizing safeguards technology development. The second problem (dissertation research) has focused on the development of a theoretical foundation for sensor array anomaly detection. Remote and unattended monitoring or verification of safeguards activities is becoming a necessity due to domestic and international budgetary constraints. However, the ability to assess the trustworthiness of a sensor array has not been investigated. This research is developing an anomaly detection methodology to assess the sensor array.

  19. Application of visible bremsstrahlung to Z{sub eff} measurement on the Experimental Advanced Superconducting Tokamak

    SciTech Connect

    Chen, Yingjie; Wu, Zhenwei; Gao, Wei; Ti, Ang; Zhang, Ling; Jie, Yinxian; Zhang, Jizong; Huang, Juan; Xu, Zong; Zhao, Junyu

    2015-02-15

    The multi-channel visible bremsstrahlung measurement system has been developed on Experimental Advanced Superconducting Tokamak (EAST). In addition to providing effective ion charge Z{sub eff} as a routine diagnostic, this diagnostic can also be used to estimate other parameters. With the assumption that Z{sub eff} can be seen as constant across the radius and does not change significantly during steady state discharges, central electron temperature, averaged electron density, electron density profile, and plasma current density profile have been obtained based on the scaling of Z{sub eff} with electron density and the relations between Z{sub eff} and these parameters. The estimated results are in good coincidence with measured values, providing an effective and convenient method to estimate other plasma parameters.

  20. Application of visible bremsstrahlung to Z(eff) measurement on the Experimental Advanced Superconducting Tokamak.

    PubMed

    Chen, Yingjie; Wu, Zhenwei; Gao, Wei; Ti, Ang; Zhang, Ling; Jie, Yinxian; Zhang, Jizong; Huang, Juan; Xu, Zong; Zhao, Junyu

    2015-02-01

    The multi-channel visible bremsstrahlung measurement system has been developed on Experimental Advanced Superconducting Tokamak (EAST). In addition to providing effective ion charge Zeff as a routine diagnostic, this diagnostic can also be used to estimate other parameters. With the assumption that Zeff can be seen as constant across the radius and does not change significantly during steady state discharges, central electron temperature, averaged electron density, electron density profile, and plasma current density profile have been obtained based on the scaling of Zeff with electron density and the relations between Zeff and these parameters. The estimated results are in good coincidence with measured values, providing an effective and convenient method to estimate other plasma parameters.

  1. Advances in Landslide Hazard Forecasting: Evaluation of Global and Regional Modeling Approach

    NASA Technical Reports Server (NTRS)

    Kirschbaum, Dalia B.; Adler, Robert; Hone, Yang; Kumar, Sujay; Peters-Lidard, Christa; Lerner-Lam, Arthur

    2010-01-01

    A prototype global satellite-based landslide hazard algorithm has been developed to identify areas that exhibit a high potential for landslide activity by combining a calculation of landslide susceptibility with satellite-derived rainfall estimates. A recent evaluation of this algorithm framework found that while this tool represents an important first step in larger-scale landslide forecasting efforts, it requires several modifications before it can be fully realized as an operational tool. The evaluation finds that the landslide forecasting may be more feasible at a regional scale. This study draws upon a prior work's recommendations to develop a new approach for considering landslide susceptibility and forecasting at the regional scale. This case study uses a database of landslides triggered by Hurricane Mitch in 1998 over four countries in Central America: Guatemala, Honduras, EI Salvador and Nicaragua. A regional susceptibility map is calculated from satellite and surface datasets using a statistical methodology. The susceptibility map is tested with a regional rainfall intensity-duration triggering relationship and results are compared to global algorithm framework for the Hurricane Mitch event. The statistical results suggest that this regional investigation provides one plausible way to approach some of the data and resolution issues identified in the global assessment, providing more realistic landslide forecasts for this case study. Evaluation of landslide hazards for this extreme event helps to identify several potential improvements of the algorithm framework, but also highlights several remaining challenges for the algorithm assessment, transferability and performance accuracy. Evaluation challenges include representation errors from comparing susceptibility maps of different spatial resolutions, biases in event-based landslide inventory data, and limited nonlandslide event data for more comprehensive evaluation. Additional factors that may improve

  2. Badhwar-O'Neil 2007 Galactic Cosmic Ray (GCR) Model Using Advanced Composition Explorer (ACE) Measurements for Solar Cycle 23

    NASA Technical Reports Server (NTRS)

    ONeill, P. M.

    2007-01-01

    Advanced Composition Explorer (ACE) satellite measurements of the galactic cosmic ray flux and correlation with the Climax Neutron Monitor count over Solar Cycle 23 are used to update the Badhwar O'Neill Galactic Cosmic Ray (GCR) model.

  3. A Unified Approach for Reporting ARM Measurement Uncertainties Technical Report

    SciTech Connect

    Campos, E; Sisterson, DL

    2015-10-01

    The Atmospheric Radiation Measurement (ARM) Climate Research Facility is observationally based, and quantifying the uncertainty of its measurements is critically important. With over 300 widely differing instruments providing over 2,500 datastreams, concise expression of measurement uncertainty is quite challenging. The ARM Facility currently provides data and supporting metadata (information about the data or data quality) to its users through a number of sources. Because the continued success of the ARM Facility depends on the known quality of its measurements, the Facility relies on instrument mentors and the ARM Data Quality Office (DQO) to ensure, assess, and report measurement quality. Therefore, an easily-accessible, well-articulated estimate of ARM measurement uncertainty is needed.

  4. Exploring the joint measurability using an information-theoretic approach

    NASA Astrophysics Data System (ADS)

    Hsu, Li-Yi

    2016-10-01

    We explore the legal purity parameters for the joint measurements. Instead of direct unsharpening the measurements, we perform the quantum cloning before the sharp measurements. The necessary fuzziness in the unsharp measurements is equivalently introduced in the imperfect cloning process. Based on the information causality and the consequent noisy nonlocal computation, one can derive the information-theoretic quadratic inequalities that must be satisfied by any physical theory. On the other hand, to guarantee the classicality, the linear Bell-type inequalities deduced by these quadratic ones must be obeyed. As for the joint measurability, the purity parameters must be chosen to obey both types of inequalities. Finally, the quadratic inequalities for purity parameters in the joint measurability region are derived.

  5. Measures of Adequacy for Library Collections in Australian Colleges of Advanced Education. Report of a Research Project Conducted on Behalf of the Commission on Advanced Education. Volume 2.

    ERIC Educational Resources Information Center

    Wainwright, E. J.; Dean, J. E.

    This volume presents an extensive review of the literature relating to collection development in tertiary institution libraries, a bibliography, and appendices for the main report of "Measures of Adequacy for Library Collections in Australian Colleges of Advanced Education" (IR 004 761). The literature review includes sections on principles of…

  6. Encouraging Advanced Second Language Speakers to Recognise Their Language Difficulties: A Personalised Computer-Based Approach

    ERIC Educational Resources Information Center

    Xu, Jing; Bull, Susan

    2010-01-01

    Despite holding advanced language qualifications, many overseas students studying at English-speaking universities still have difficulties in formulating grammatically correct sentences. This article introduces an "independent open learner model" for advanced second language speakers of English, which confronts students with the state of their…

  7. Measured and predicted rotor performance for the SERI advanced wind turbine blades

    NASA Astrophysics Data System (ADS)

    Tangler, J.; Smith, B.; Kelley, N.; Jager, D.

    1992-02-01

    Measured and predicted rotor performance for the Solar Energy Research Institute (SERI) advanced wind turbine blades were compared to assess the accuracy of predictions and to identify the sources of error affecting both predictions and measurements. An awareness of these sources of error contributes to improved prediction and measurement methods that will ultimately benefit future rotor design efforts. Propeller/vane anemometers were found to underestimate the wind speed in turbulent environments such as the San Gorgonio Pass wind farm area. Using sonic or cup anemometers, good agreement was achieved between predicted and measured power output for wind speeds up to 8 m/sec. At higher wind speeds an optimistic predicted power output and the occurrence of peak power at wind speeds lower than measurements resulted from the omission of turbulence and yaw error. In addition, accurate two-dimensional (2-D) airfoil data prior to stall and a post stall airfoil data synthesization method that reflects three-dimensional (3-D) effects were found to be essential for accurate performance prediction.

  8. Measurements of the subcriticality using advanced technique of shooting source during operation of NPP reactors

    SciTech Connect

    Lebedev, G. V. Petrov, V. V.; Bobylyov, V. T.; Butov, R. I.; Zhukov, A. M.; Sladkov, A. A.

    2014-12-15

    According to the rules of nuclear safety, the measurements of the subcriticality of reactors should be carried out in the process of performing nuclear hazardous operations. An advanced technique of shooting source of neutrons is proposed to meet this requirement. As such a source, a pulsed neutron source (PNS) is used. In order to realize this technique, it is recommended to enable a PNS with a frequency of 1–20 Hz. The PNS is stopped after achieving a steady-state (on average) number of neutrons in the reactor volume. The change in the number of neutrons in the reactor volume is measured in time with an interval of discreteness of ∼0.1 s. The results of these measurements with the application of a system of point-kinetics equations are used in order to calculate the sought subcriticality. The basic idea of the proposed technique used to measure the subcriticality is elaborated in a series of experiments on the Kvant assembly. The conditions which should be implemented in order to obtain a positive result of measurements are formulated. A block diagram of the basic version of the experimental setup is presented, whose main element is a pulsed neutron generator.

  9. Measurements of the subcriticality using advanced technique of shooting source during operation of NPP reactors

    NASA Astrophysics Data System (ADS)

    Lebedev, G. V.; Petrov, V. V.; Bobylyov, V. T.; Butov, R. I.; Zhukov, A. M.; Sladkov, A. A.

    2014-12-01

    According to the rules of nuclear safety, the measurements of the subcriticality of reactors should be carried out in the process of performing nuclear hazardous operations. An advanced technique of shooting source of neutrons is proposed to meet this requirement. As such a source, a pulsed neutron source (PNS) is used. In order to realize this technique, it is recommended to enable a PNS with a frequency of 1-20 Hz. The PNS is stopped after achieving a steady-state (on average) number of neutrons in the reactor volume. The change in the number of neutrons in the reactor volume is measured in time with an interval of discreteness of ˜0.1 s. The results of these measurements with the application of a system of point-kinetics equations are used in order to calculate the sought subcriticality. The basic idea of the proposed technique used to measure the subcriticality is elaborated in a series of experiments on the Kvant assembly. The conditions which should be implemented in order to obtain a positive result of measurements are formulated. A block diagram of the basic version of the experimental setup is presented, whose main element is a pulsed neutron generator.

  10. Approach to market-penetration analysis for advanced electric-power-generation technologies

    SciTech Connect

    Lamontagne, J.; Love, P.; Queirolo, A.

    1980-12-01

    If commercialization of new technologies is the primary objective of the Department of Energy's Research, Development and Demonstration (RD and D) programs, the ultimate measure of benefit from RD and D programs is the extent of commercial acceptance of the developed technologies. Uncertainty about barriers to commercialization - government policy, fuel supply, etc. - make the task of estimating this acceptance very difficult. However, given that decisions must be made regarding allocation of RD and D funds, the best information available, with due regard for uncertainty, should serve as input to these decisions. An approach is presented for quantifying the range of market potential for new technologies (specifically in the utility sector) based on historical information and known plans for the future.

  11. Advances in the regionalization approach: geostatistical techniques for estimating flood quantiles

    NASA Astrophysics Data System (ADS)

    Chiarello, Valentina; Caporali, Enrica; Matthies, Hermann G.

    2015-04-01

    The knowledge of peak flow discharges and associated floods is of primary importance in engineering practice for planning of water resources and risk assessment. Streamflow characteristics are usually estimated starting from measurements of river discharges at stream gauging stations. However, the lack of observations at site of interest as well as the measurement inaccuracies, bring inevitably to the necessity of developing predictive models. Regional analysis is a classical approach to estimate river flow characteristics at sites where little or no data exists. Specific techniques are needed to regionalize the hydrological variables over the considered area. Top-kriging or topological kriging, is a kriging interpolation procedure that takes into account the geometric organization and structure of hydrographic network, the catchment area and the nested nature of catchments. The continuous processes in space defined for the point variables are represented by a variogram. In Top-kriging, the measurements are not point values but are defined over a non-zero catchment area. Top-kriging is applied here over the geographical space of Tuscany Region, in Central Italy. The analysis is carried out on the discharge data of 57 consistent runoff gauges, recorded from 1923 to 2014. Top-kriging give also an estimation of the prediction uncertainty in addition to the prediction itself. The results are validated using a cross-validation procedure implemented in the package rtop of the open source statistical environment R The results are compared through different error measurement methods. Top-kriging seems to perform better in nested catchments and larger scale catchments but no for headwater or where there is a high variability for neighbouring catchments.

  12. Flight-test measurement of the noise reduction of a jet transport delayed flap approach procedure

    NASA Technical Reports Server (NTRS)

    Foster, J. D.; Lasagna, P. L.

    1976-01-01

    A delayed flap approach procedure was flight tested using the NASA CV-990 airplane to measure and analyze the noise produced beneath the flight path. Three other types of landing approaches were also flight tested to provide a comparison of the noise reduction benefits to the delayed flap approach. The conventional type of approach was used as a baseline to compare the effectiveness of the other approaches. The decelerating approach is a variation of the delayed flap approach. A detailed comparison of the ground perceived noise generated during the approaches is presented. For this comparison, the measured noise data were normalized to compensate for variations in aircraft weight and winds that occurred during the flight tests. The data show that the reduced flap approach offers some noise reduction, while the delayed flap and decelerating approaches offer significant noise reductions over the conventional approach.

  13. Solid-state dosimeters: A new approach for mammography measurements

    SciTech Connect

    Brateman, Libby F.; Heintz, Philip H.

    2015-02-15

    Purpose: To compare responses of modern commercially available solid-state dosimeters (SStDs) used in mammography medical physics surveys for two major vendors of current digital mammography units. To compare differences in dose estimates among SStD responses with ionization chamber (IC) measurements for several target/filter (TF) combinations and report their characteristics. To review scientific bases for measurements of quantities required for mammography for traditional measurement procedures and SStDs. Methods: SStDs designed for use with modern digital mammography units were acquired for evaluation from four manufacturers. Each instrument was evaluated under similar conditions with the available mammography beams provided by two modern full-field digital mammography units in clinical use: a GE Healthcare Senographe Essential (Essential) and a Hologic Selenia Dimensions 5000 (Dimensions), with TFs of Mo/Mo, Mo/Rh; and Rh/Rh and W/Rh, W/Ag, and W/Al, respectively. Measurements were compared among the instruments for the TFs over their respective clinical ranges of peak tube potentials for kVp and half-value layer (HVL) measurements. Comparisons for air kerma (AK) and their associated relative calculated average glandular doses (AGDs), i.e., using fixed mAs, were evaluated over the limited range of 28–30 kVp. Measurements were compared with reference IC measurements for AK, reference HVLs and calculated AGD, for two compression paddle heights for AK, to evaluate scatter effects from compression paddles. SStDs may require different positioning from current mammography measurement protocols. Results: Measurements of kVp were accurate in general for the SStDs (within −1.2 and +1.1 kVp) for all instruments over a wide range of set kVp’s and TFs and most accurate for Mo/Mo and W/Rh. Discrepancies between measurements and reference values were greater for HVL and AK. Measured HVL values differed from reference values by −6.5% to +3.5% depending on the SStD and

  14. Defining and Measuring Entrepreneurship for Regional Research: A New Approach

    ERIC Educational Resources Information Center

    Low, Sarah A.

    2009-01-01

    In this dissertation, I develop a definition and regional measure of entrepreneurship that will aid entrepreneurship research and economic development policy. My new indicators represent an improvement over current measures of entrepreneurship. The chief contribution of these new indicators is that they incorporate innovation, which others ignore.…

  15. The Relative Importance of Job Factors: A New Measurement Approach.

    ERIC Educational Resources Information Center

    Nealey, Stanley M.

    This paper reports on a new two-phase measurement technique that permits a direct comparison of the perceived relative importance of economic vs. non-economic factors in a job situation in accounting for personnel retention, the willingness to produce, and job satisfaction. The paired comparison method was used to measure the preferences of 91…

  16. A novel approach to Hugoniot measurements utilizing transparent crystals

    SciTech Connect

    Fratanduono, D. E.; Eggert, J. H.; Akin, M. C.; Chau, R.; Holmes, N. C.

    2013-01-01

    A new absolute equation of state measurement technique is described and demonstrated measuring the shock state and the refractive index of MgO up to 226GPa. This technique utilizes steady shock waves and the high-pressure transparency of MgO under dynamic shock compression and release. Hugoniot measurements performed using this technique are consistent with the previous measurements. A linear dependence of the shocked refractive index and density is observed up to 226GPa, over a magnitude greater in pressure that previous studies. The transparency of MgO along the principal Hugoniot is higher than any other material reported to date. We observe a significant change in the refractive index of MgO as the Hugoniot elastic limit is exceeded due to the transition from uniaxial to hydrostatic strain. Measurements of the elastic-plastic two-wave structure in MgO indicate a nucleation time for plastic deformation.

  17. Measuring Nitrification: A Laboratory Approach to Nutrient Cycling.

    ERIC Educational Resources Information Center

    Hicks, David J.

    1990-01-01

    Presented is an approach to the study of nutrient cycling in the school laboratory. Discussed are obtaining, processing, and incubating samples; extraction of ions from soil; procedures for nitrate and ammonium analysis; data analysis; an example of results; and other aspects of the nitrogen cycle. (CW)

  18. AISI/DOE Advanced Process Control Program Vol. 5 of 6: Phase Measurement of Galvanneal

    SciTech Connect

    Cristopher Burnett; Ronald Guel; James R. Philips; L. Lowry; Beverly Tai

    1999-05-31

    Augmentation of the internal software of a commercial X-ray fluorescence gauge is shown to enable the instrument to extend its continuous on-line real-time measurements of a galvanneal coating's total elemental content to encompass similar measurements of the relative thickness of the coating's three principal metallurgical phases. The mathematical structure of this software augmentation is derived from the theory of neural networks. The performance of the augmented gauge is validated by comparing the gauge implied real-time phase distribution with the phase distribution independently measured off-line on between the gauge and laboratory measurements and to suggest preferred approaches to be followed in future application of the augmented gauge.

  19. Recent Advances in AC-DC Transfer Measurements Using Thin-Film Thermal Converters

    SciTech Connect

    WUNSCH,THOMAS F.; KINARD,JOSEPH R.; MANGINELL,RONALD P.; LIPE,THOMAS E.; SOLOMON JR.,OTIS M.; JUNGLING,KENNETH C.

    2000-12-08

    New standards for ac current and voltage measurements, thin-film multifunction thermal converters (MJTCS), have been fabricated using thin-film and micro-electro-mechanical systems (MEMS) technology. Improved sensitivity and accuracy over single-junction thermoelements and targeted performance will allow new measurement approaches in traditionally troublesome areas such as the low frequency and high current regimes. A review is presented of new microfabrication techniques and packaging methods that have resulted from a collaborative effort at Sandia National Laboratories and the National Institute of Standards and Technology (MHZ).

  20. Advancing the science of measurement of diagnostic errors in healthcare: the Safer Dx framework

    PubMed Central

    Singh, Hardeep; Sittig, Dean F

    2015-01-01

    Diagnostic errors are major contributors to harmful patient outcomes, yet they remain a relatively understudied and unmeasured area of patient safety. Although they are estimated to affect about 12 million Americans each year in ambulatory care settings alone, both the conceptual and pragmatic scientific foundation for their measurement is under-developed. Health care organizations do not have the tools and strategies to measure diagnostic safety and most have not integrated diagnostic error into their existing patient safety programs. Further progress toward reducing diagnostic errors will hinge on our ability to overcome measurement-related challenges. In order to lay a robust groundwork for measurement and monitoring techniques to ensure diagnostic safety, we recently developed a multifaceted framework to advance the science of measuring diagnostic errors (The Safer Dx framework). In this paper, we describe how the framework serves as a conceptual foundation for system-wide safety measurement, monitoring and improvement of diagnostic error. The framework accounts for the complex adaptive sociotechnical system in which diagnosis takes place (the structure), the distributed process dimensions in which diagnoses evolve beyond the doctor's visit (the process) and the outcomes of a correct and timely “safe diagnosis” as well as patient and health care outcomes (the outcomes). We posit that the Safer Dx framework can be used by a variety of stakeholders including researchers, clinicians, health care organizations and policymakers, to stimulate both retrospective and more proactive measurement of diagnostic errors. The feedback and learning that would result will help develop subsequent interventions that lead to safer diagnosis, improved value of health care delivery and improved patient outcomes. PMID:25589094

  1. MPACT FY2011 Advanced Time-Correlated Measurement Research at INL

    SciTech Connect

    D. L. Chichester; S. A. Pozzi; J. L. Dolan; M. Flaska; S. M. Watson

    2011-09-01

    Simulations and experiments have been carried out to investigate advanced time-correlated measurement methods for characterizing and assaying nuclear material for safeguarding the nuclear fuel cycle. These activities are part of a project studying advanced instrumentation techniques in support of the U.S. Department of Energy's Fuel Cycle Research and Development program and its Materials Protection, Accounting, and Control Technologies (MPACT) program. For fiscal year 2011 work focused on examining the practical experimental aspects of using a time-tagged, associated-particle electronic neutron generator for interrogating low-enrichment uranium in combination with steady-state interrogation using a moderated 241Am-Li neutron source. Simulation work for the project involved the use of the MCNP-PoliMi Monte Carlo simulation tool to determine the relative strength and the time-of-flight energy spectra of different sample materials under irradiation. Work also took place to develop a post-processor parser code to extract comparable data from the MCNP5&6 codes. Experiments took place using a commercial deuterium-tritium associated-particle electronic neutron generator to irradiate a number of uranium-bearing material samples. Time-correlated measurements of neutron and photon signatures of these measurements were made using five liquid scintillator detectors in a novel array, using high-speed waveform digitizers for data collection. This report summarizes the experiments that took place in FY2011, presents preliminary analyses that have been carried out to date for a subpart of these experiments, and describes future activities planned in this area. The report also describes support Idaho National Laboratory gave to Oak Ridge National Laboratory in 2011 to facilitate 2-dimensional imagery of mixed-oxide fuel pins for safeguards applications as a part of the MPACT program.

  2. Advancements in Root Growth Measurement Technologies and Observation Capabilities for Container-Grown Plants.

    PubMed

    Judd, Lesley A; Jackson, Brian E; Fonteno, William C

    2015-07-03

    The study, characterization, observation, and quantification of plant root growth and root systems (Rhizometrics) has been and remains an important area of research in all disciplines of plant science. In the horticultural industry, a large portion of the crops grown annually are grown in pot culture. Root growth is a critical component in overall plant performance during production in containers, and therefore it is important to understand the factors that influence and/or possible enhance it. Quantifying root growth has varied over the last several decades with each method of quantification changing in its reliability of measurement and variation among the results. Methods such as root drawings, pin boards, rhizotrons, and minirhizotrons initiated the aptitude to measure roots with field crops, and have been expanded to container-grown plants. However, many of the published research methods are monotonous and time-consuming. More recently, computer programs have increased in use as technology advances and measuring characteristics of root growth becomes easier. These programs are instrumental in analyzing various root growth characteristics, from root diameter and length of individual roots to branching angle and topological depth of the root architecture. This review delves into the expanding technologies involved with expertly measuring root growth of plants in containers, and the advantages and disadvantages that remain.

  3. Advancements in Root Growth Measurement Technologies and Observation Capabilities for Container-Grown Plants

    PubMed Central

    Judd, Lesley A.; Jackson, Brian E.; Fonteno, William C.

    2015-01-01

    The study, characterization, observation, and quantification of plant root growth and root systems (Rhizometrics) has been and remains an important area of research in all disciplines of plant science. In the horticultural industry, a large portion of the crops grown annually are grown in pot culture. Root growth is a critical component in overall plant performance during production in containers, and therefore it is important to understand the factors that influence and/or possible enhance it. Quantifying root growth has varied over the last several decades with each method of quantification changing in its reliability of measurement and variation among the results. Methods such as root drawings, pin boards, rhizotrons, and minirhizotrons initiated the aptitude to measure roots with field crops, and have been expanded to container-grown plants. However, many of the published research methods are monotonous and time-consuming. More recently, computer programs have increased in use as technology advances and measuring characteristics of root growth becomes easier. These programs are instrumental in analyzing various root growth characteristics, from root diameter and length of individual roots to branching angle and topological depth of the root architecture. This review delves into the expanding technologies involved with expertly measuring root growth of plants in containers, and the advantages and disadvantages that remain. PMID:27135334

  4. Reflectivity and scattering measurements of an Advanced X-ray Astrophysics Facility test coating sample

    NASA Astrophysics Data System (ADS)

    Bixler, J. V.; Mauche, C. W.; Hailey, C. J.; Madison, L.

    1995-10-01

    Reflectivity and scattering profile measurements were made on a gold-coated witness sample produced to evaluate mirror coatings for the Advanced X-ray Astrophysics Facility program. Reflectivity measurements were made at Al K, Ti K, and Cu K energies as a function of incident graze angle. The results are fit to a model that includes the effects of roughness, particulate and organic contamination layers, and gold-coating density. Reflectivities are close to theoretical, with the difference being well accounted for by 4.1 A of roughness at spatial frequencies above 4 mu m-1, a gold-coating density equal to 0.98 bulk, and a surface contaminant layer 27 A thick. Scattering measurements extending to +/-35 arcmin of the line center were obtained by the use of Al K x rays and incidence angles from 0.75 deg to 3 deg The scattering profiles imply a power spectral density of surface-scattering frequencies that follows a power law with an index of -1.0 and a total surface roughness for the spatial frequency band between 0.05 mu m-1 and 4 mu m -1 of 3.3 A. Combining the roughnesses derived from both the reflectivity and scattering measurements yields a total roughness of 5.3 A for scattering frequencies between 0.05 mu m-1 and 15,000 mu m-1.

  5. Simple Approaches for Measuring Dry Atmospheric Nitrogen Deposition to Watersheds

    EPA Science Inventory

    Assessing the effects of atmospheric nitrogen (N) deposition on surface water quality requires accurate accounts of total N deposition (wet, dry, and cloud vapor); however, dry deposition is difficult to measure and is often spatially variable. Affordable passive sampling methods...

  6. Two Automated Techniques for Carotid Lumen Diameter Measurement: Regional versus Boundary Approaches.

    PubMed

    Araki, Tadashi; Kumar, P Krishna; Suri, Harman S; Ikeda, Nobutaka; Gupta, Ajay; Saba, Luca; Rajan, Jeny; Lavra, Francesco; Sharma, Aditya M; Shafique, Shoaib; Nicolaides, Andrew; Laird, John R; Suri, Jasjit S

    2016-07-01

    The degree of stenosis in the carotid artery can be predicted using automated carotid lumen diameter (LD) measured from B-mode ultrasound images. Systolic velocity-based methods for measurement of LD are subjective. With the advancement of high resolution imaging, image-based methods have started to emerge. However, they require robust image analysis for accurate LD measurement. This paper presents two different algorithms for automated segmentation of the lumen borders in carotid ultrasound images. Both algorithms are modeled as a two stage process. Stage one consists of a global-based model using scale-space framework for the extraction of the region of interest. This stage is common to both algorithms. Stage two is modeled using a local-based strategy that extracts the lumen interfaces. At this stage, the algorithm-1 is modeled as a region-based strategy using a classification framework, whereas the algorithm-2 is modeled as a boundary-based approach that uses the level set framework. Two sets of databases (DB), Japan DB (JDB) (202 patients, 404 images) and Hong Kong DB (HKDB) (50 patients, 300 images) were used in this study. Two trained neuroradiologists performed manual LD tracings. The mean automated LD measured was 6.35 ± 0.95 mm for JDB and 6.20 ± 1.35 mm for HKDB. The precision-of-merit was: 97.4 % and 98.0 % w.r.t to two manual tracings for JDB and 99.7 % and 97.9 % w.r.t to two manual tracings for HKDB. Statistical tests such as ANOVA, Chi-Squared, T-test, and Mann-Whitney test were conducted to show the stability and reliability of the automated techniques. PMID:27299355

  7. Advanced video extensometer for non-contact, real-time, high-accuracy strain measurement.

    PubMed

    Pan, Bing; Tian, Long

    2016-08-22

    We developed an advanced video extensometer for non-contact, real-time, high-accuracy strain measurement in material testing. In the established video extensometer, a "near perfect and ultra-stable" imaging system, combining the idea of active imaging with a high-quality bilateral telecentric lens, is constructed to acquire high-fidelity video images of the test sample surface, which is invariant to ambient lighting changes and small out-of-plane motions occurred between the object surface and image plane. In addition, an efficient and accurate inverse compositional Gauss-Newton algorithm incorporating a temporal initial guess transfer scheme and a high-accuracy interpolation method is employed to achieve real-time, high-accuracy displacement tracking with negligible bias error. Tensile tests of an aluminum sample and a carbon fiber filament sample were performed to demonstrate the efficiency, repeatability and accuracy of the developed advanced video extensometer. The results indicate that longitudinal and transversal strains can be estimated and plotted at a rate of 117 fps and with a maximum strain error less than 30 microstrains. PMID:27557188

  8. Advances in GRAIL Gravity Field Determination Using the Celestial Mechanics Approach

    NASA Astrophysics Data System (ADS)

    Bertone, S.; Arnold, D.; Jaeggi, A.; Beutler, G.; Mervart, L.

    2015-12-01

    The NASA mission GRAIL inherits its concept from the GRACE mission to determine the gravity field of the Moon. The use of inter-satellite Ka-band range-rate (KBRR) observations enables data acquisition even when the spacecraft are not tracked from the Earth. The data allows for a highly accurate estimation of the lunar gravity field on both sides of the Moon, which is leading to huge improvements in our understanding of its internal structure and thermal evolution. In this presentation we discuss the latest GRAIL-based lunar gravity fields generated with the Celestial Mechanics Approach using the Bernese GNSS Software. We present our recent solutions up to d/o 200, where KBRR observations and position data (GNI1B products) were used to solve for the lunar gravity field parameters in a generalized orbit determination problem. We detail our parametrization in terms of pseudo-stochastic pulses and empirical accelerations, which allows for high quality results even while using a simple model of non-gravitational forces and pre-GRAIL a priori fields. Moreover, we present our latest advances towards the computation of a lunar gravity field with improved spatial resolution.As a further extension of our processing, the GNI1B positions are replaced by the original Doppler observations of the Deep Space Network (DSN) to allow for a completely independent determination of the lunar gravity field. Based on Doppler data, we perform orbit determination by solving six initial orbital elements, dynamical parameters, and stochastic parameters in daily arcs using least squares-adjustment. The pseudo-stochastic parameters are estimated to absorb deficiencies in our dynamical modeling (e.g. due to non-gravitational forces). DSN Doppler and KBRR data are then used together with an appropriate weighting for a combined orbit determination process. We present our latest results in the orbit determination of GRAIL over the primary mission phase (PM, March-May 2012) and eventually present

  9. Probabilistic approach to cloud and snow detection on Advanced Very High Resolution Radiometer (AVHRR) imagery

    NASA Astrophysics Data System (ADS)

    Musial, J. P.; Hüsler, F.; Sütterlin, M.; Neuhaus, C.; Wunderle, S.

    2014-03-01

    Derivation of probability estimates complementary to geophysical data sets has gained special attention over the last years. Information about a confidence level of provided physical quantities is required to construct an error budget of higher-level products and to correctly interpret final results of a particular analysis. Regarding the generation of products based on satellite data a common input consists of a cloud mask which allows discrimination between surface and cloud signals. Further the surface information is divided between snow and snow-free components. At any step of this discrimination process a misclassification in a cloud/snow mask propagates to higher-level products and may alter their usability. Within this scope a novel probabilistic cloud mask (PCM) algorithm suited for the 1 km × 1 km Advanced Very High Resolution Radiometer (AVHRR) data is proposed which provides three types of probability estimates between: cloudy/clear-sky, cloudy/snow and clear-sky/snow conditions. As opposed to the majority of available techniques which are usually based on the decision-tree approach in the PCM algorithm all spectral, angular and ancillary information is used in a single step to retrieve probability estimates from the precomputed look-up tables (LUTs). Moreover, the issue of derivation of a single threshold value for a spectral test was overcome by the concept of multidimensional information space which is divided into small bins by an extensive set of intervals. The discrimination between snow and ice clouds and detection of broken, thin clouds was enhanced by means of the invariant coordinate system (ICS) transformation. The study area covers a wide range of environmental conditions spanning from Iceland through central Europe to northern parts of Africa which exhibit diverse difficulties for cloud/snow masking algorithms. The retrieved PCM cloud classification was compared to the Polar Platform System (PPS) version 2012 and Moderate Resolution Imaging

  10. Sampling Approaches for Multi-Domain Internet Performance Measurement Infrastructures

    SciTech Connect

    Calyam, Prasad

    2014-09-15

    The next-generation of high-performance networks being developed in DOE communities are critical for supporting current and emerging data-intensive science applications. The goal of this project is to investigate multi-domain network status sampling techniques and tools to measure/analyze performance, and thereby provide “network awareness” to end-users and network operators in DOE communities. We leverage the infrastructure and datasets available through perfSONAR, which is a multi-domain measurement framework that has been widely deployed in high-performance computing and networking communities; the DOE community is a core developer and the largest adopter of perfSONAR. Our investigations include development of semantic scheduling algorithms, measurement federation policies, and tools to sample multi-domain and multi-layer network status within perfSONAR deployments. We validate our algorithms and policies with end-to-end measurement analysis tools for various monitoring objectives such as network weather forecasting, anomaly detection, and fault-diagnosis. In addition, we develop a multi-domain architecture for an enterprise-specific perfSONAR deployment that can implement monitoring-objective based sampling and that adheres to any domain-specific measurement policies.

  11. The Fitness Landscape of HIV-1 Gag: Advanced Modeling Approaches and Validation of Model Predictions by In Vitro Testing

    PubMed Central

    Omarjee, Saleha; Walker, Bruce D.; Chakraborty, Arup; Ndung'u, Thumbi

    2014-01-01

    Viral immune evasion by sequence variation is a major hindrance to HIV-1 vaccine design. To address this challenge, our group has developed a computational model, rooted in physics, that aims to predict the fitness landscape of HIV-1 proteins in order to design vaccine immunogens that lead to impaired viral fitness, thus blocking viable escape routes. Here, we advance the computational models to address previous limitations, and directly test model predictions against in vitro fitness measurements of HIV-1 strains containing multiple Gag mutations. We incorporated regularization into the model fitting procedure to address finite sampling. Further, we developed a model that accounts for the specific identity of mutant amino acids (Potts model), generalizing our previous approach (Ising model) that is unable to distinguish between different mutant amino acids. Gag mutation combinations (17 pairs, 1 triple and 25 single mutations within these) predicted to be either harmful to HIV-1 viability or fitness-neutral were introduced into HIV-1 NL4-3 by site-directed mutagenesis and replication capacities of these mutants were assayed in vitro. The predicted and measured fitness of the corresponding mutants for the original Ising model (r = −0.74, p = 3.6×10−6) are strongly correlated, and this was further strengthened in the regularized Ising model (r = −0.83, p = 3.7×10−12). Performance of the Potts model (r = −0.73, p = 9.7×10−9) was similar to that of the Ising model, indicating that the binary approximation is sufficient for capturing fitness effects of common mutants at sites of low amino acid diversity. However, we show that the Potts model is expected to improve predictive power for more variable proteins. Overall, our results support the ability of the computational models to robustly predict the relative fitness of mutant viral strains, and indicate the potential value of this approach for understanding viral immune evasion

  12. Constrained independent component analysis approach to nonobtrusive pulse rate measurements

    NASA Astrophysics Data System (ADS)

    Tsouri, Gill R.; Kyal, Survi; Dianat, Sohail; Mestha, Lalit K.

    2012-07-01

    Nonobtrusive pulse rate measurement using a webcam is considered. We demonstrate how state-of-the-art algorithms based on independent component analysis suffer from a sorting problem which hinders their performance, and propose a novel algorithm based on constrained independent component analysis to improve performance. We present how the proposed algorithm extracts a photoplethysmography signal and resolves the sorting problem. In addition, we perform a comparative study between the proposed algorithm and state-of-the-art algorithms over 45 video streams using a finger probe oxymeter for reference measurements. The proposed algorithm provides improved accuracy: the root mean square error is decreased from 20.6 and 9.5 beats per minute (bpm) for existing algorithms to 3.5 bpm for the proposed algorithm. An error of 3.5 bpm is within the inaccuracy expected from the reference measurements. This implies that the proposed algorithm provided performance of equal accuracy to the finger probe oximeter.

  13. A computer simulation approach to measurement of human control strategy

    NASA Technical Reports Server (NTRS)

    Green, J.; Davenport, E. L.; Engler, H. F.; Sears, W. E., III

    1982-01-01

    Human control strategy is measured through use of a psychologically-based computer simulation which reflects a broader theory of control behavior. The simulation is called the human operator performance emulator, or HOPE. HOPE was designed to emulate control learning in a one-dimensional preview tracking task and to measure control strategy in that setting. When given a numerical representation of a track and information about current position in relation to that track, HOPE generates positions for a stick controlling the cursor to be moved along the track. In other words, HOPE generates control stick behavior corresponding to that which might be used by a person learning preview tracking.

  14. Harmonic Measuring Approach Based on Quantum Neural Network

    NASA Astrophysics Data System (ADS)

    Li, Yueling; Wu, Xinghua

    Develop a quantum neural network with more effective study and generalized ability. A method proposed to measure the parameters of harmonic is three lays quantum neural networks. With the example of 3rd and 5th harmonic parameters, elaborates the composition of the training method and training sample in the quantum neuron networks. A simulation which trains the quantum neutron network with training samples firstly, then measures untrained samples, is performed by Matlab programs. And the results of the simulation show the validity of the method.

  15. RECENT BEAM MEASUREMENTS AND NEW INSTRUMENTATION AT THE ADVANCED LIGHT SOURCE

    SciTech Connect

    Sannibale, Fernando; Baptiste, Kenneth; Barry, Walter; Chin, Michael; Filippetto, Daniele; Jaegerhofer, Lukas; Julian, James; Kwiatkowski, Slawomir; Low, Raymond; Plate, David; Portmann, Gregory; Robin, David; Scarvie, Tomas; Stupakov, Gennady; Weber, Jonah; Zolotorev, Max

    2008-05-05

    The Advanced Light Source (ALS) in Berkeley was the first of the soft x-ray third generation light source ever built, and since 1993 has been in continuous and successful operation serving a large community of users in the VUV and soft x-ray community. During these years the storage ring underwent through several important upgrades that allowed maintaining the performance of this veteran facility at the forefront. The ALS beam diagnostics and instrumentation have followed a similar path of innovation and upgrade and nowadays include most of the modem and last generation devices and technologies that are commercially available and used in the recently constructed third generation light sources. In this paper we will not focus on such already widely known systems, but we will concentrate our effort in the description of some measurements techniques, instrumentation and diagnostic systems specifically developed at the ALS and used during the last few years.

  16. Recent Beam Measurements and New Instrumentation at the Advanced Light Source

    SciTech Connect

    Sannibale, F.; Baptiste, K.; Barry, W.; Chin, M.; Filippetto, D.; Jaegerhofer, L.; Julian, J.; Kwiatkowski, S.; Low, R.; Plate, D.; Portmann, G.; Robin, D.; Scarvie, T.; Stupakov, G.; Weber, J.; Zolotorev, M.; /LBL, Berkeley

    2012-04-11

    The Advanced Light Source (ALS) in Berkeley was the first of the soft x-ray third generation light source ever built, and since 1993 has been in continuous and successful operation serving a large community of users in the VUV and soft x-ray community. During these years the storage ring underwent through several important upgrades that allowed maintaining the performance of this veteran facility at the forefront. The ALS beam diagnostics and instrumentation have followed a similar path of innovation and upgrade and nowadays include most of the modem and last generation devices and technologies that are commercially available and used in the recently constructed third generation light sources. In this paper we will not focus on such already widely known systems, but we will concentrate our effort in the description of some measurements techniques, instrumentation and diagnostic systems specifically developed at the ALS and used during the last few years.

  17. The CNO Concentration in Cosmic Ray Spectrum as Measured From The Advanced Thin Ionization Calorimeter Experiment

    NASA Technical Reports Server (NTRS)

    Fazely, A. R.; Gunasingha, R. M.; Adams, James H., Jr.; Ahn, H.; Ampe, J.; Bashindzhagyan, G.; Whitaker, Ann F. (Technical Monitor)

    2001-01-01

    We present preliminary results on the spectra of CNO nuclei in the cosmic radiation as measured in the first flight of the Advanced Thin Ionization Calorimeter Balloon Experiment (ATIC) which lasted for 16 days, starting in December, 2000 with a launch from McMurdo, Antarctica. ATIC is a multiple, long duration balloon flight, investigation for the study of cosmic ray spectra from below 50 GeV to near 100 TeV total energy, using a fully active Bismuth Germanate (BGO) calorimeter. It is equipped with the first large area mosaic of small fully depleted silicon detector pads capable of charge identification in cosmic rays from H to Fe. As a redundancy check for the charge identification and a coarse particle tracking system, three projective layers of x-y scintillator hodoscopes were employed, above, in the center and below a Carbon interaction "target".

  18. Optical Fuel Injector Patternation Measurements in Advanced Liquid-Fueled, High Pressure, Gas Turbine Combustors

    NASA Technical Reports Server (NTRS)

    Locke, R. J.; Hicks, Y. R.; Anderson, R. C.; Zaller, M. M.

    1998-01-01

    Planar laser-induced fluorescence (PLIF) imaging and planar Mie scattering are used to examine the fuel distribution pattern (patternation) for advanced fuel injector concepts in kerosene burning, high pressure gas turbine combustors. Three fuel injector concepts for aerospace applications were investigated under a broad range of operating conditions. Fuel PLIF patternation results are contrasted with those obtained by planar Mie scattering. For one injector, further comparison is also made with data obtained through phase Doppler measurements. Differences in spray patterns for diverse conditions and fuel injector configurations are readily discernible. An examination of the data has shown that a direct determination of the fuel spray angle at realistic conditions is also possible. The results obtained in this study demonstrate the applicability and usefulness of these nonintrusive optical techniques for investigating fuel spray patternation under actual combustor conditions.

  19. DESIGN, PROTOTYPE AND MEASUREMENT OF A SINGLE-CELL DEFLECTING CAVITY FOR THE ADVANCED PHOTON SOURCE

    SciTech Connect

    Haipeng Wang, Guangfeng Cheng, Gianluigi Ciovati, Peter Kneisel, Robert Rimmer, Kai Tian, Larry Turlington, Alireza Nassiri, Geoff Waldschmidt

    2009-05-01

    After the design optimization of a squashed elliptical shape, single-cell, superconducting (SC) deflecting cavity at 2.815 GHz, a copper prototype has been bench measured to determine its rf properties and the effectiveness of waveguide damping of parasitic modes [1]. RF cold tests were also performed at 2K on niobium single-cell and two-cell prototype cavities. Details of impedance calculation using wakefiled analysis of the single-cell cavity are shown to meet the strict 200 mA beam stability requirement of the Advanced Photon Source (APS) at Argonne National Lab where a total of 16 single-cell cavities will be divided into two cryomodule. The design of higher-order mode (HOM) waveguide damping, the simulations of the Lorenz force detuning, and the prototype of on-cell damping are presented.

  20. Science-Based Approach for Advancing Marine and Hydrokinetic Energy: Integrating Numerical Simulations with Experiments

    NASA Astrophysics Data System (ADS)

    Sotiropoulos, F.; Kang, S.; Chamorro, L. P.; Hill, C.

    2011-12-01

    experimentally in the St. Anthony Falls Laboratory Main Channel. The experiments and simulations are compared with each other and shown to be in very good agreement both in terms of the mean flow and the turbulence statistics. The results are analyzed to study the structure of turbulence in the wake of the turbine and also identify the effects of turbulent fluctuations in the approach flow on the power produced by the turbine. Overall our results make a strong case that high-resolution numerical modeling, validated with detailed laboratory measurements, is a viable tool for assessing and optimizing the performance of MHK devices.

  1. Novel generic approach to reliable rapid analytical and bioanalytical measurements

    NASA Astrophysics Data System (ADS)

    Hislip, Shirley; Pennarun Thomas, Gaelle; Manning, Bernadette M.; O'Kennedy, Richard; Edwards, Steve; Diamond, Dermot

    1999-11-01

    There is a clear need for a portable analytical system with high sample throughput, which yields rapid and clear results at a field level for color-based assays. ELISA is a widely used technique for environmental and clinical analysis. However it is time consuming, non-portable, requires expensive plate reading equipment and skilled analysts. An alternative system has been developed in our laboratories using a digital camcorder as a detection method. Preliminary results generated in our laboratories using this approach to screen antibody-antigen reactions have been very promising.

  2. Does measurement noise increase as a phase transition is approached?

    NASA Astrophysics Data System (ADS)

    Chen, Zhi; Yu, Clare C.

    2007-06-01

    We study the energy and magnetization noise spectra associated with first and second order phase transitions by using Monte Carlo simulations of the Ising model and 5-state Potts model in 2D. For a finite size system, the total noise power and the low frequency white noise S(f < f knee) increase as T c is approached. In the thermodynamic limit S(f < f knee) diverges but f knee --> 0 and the total noise power vanishes. f -1 knee is approximately the equilibration time. At high frequencies S(f > f knee) ~ f -μ. For the Ising model, we relate μ to the critical exponents.

  3. Recent Advances in Ligand-Based Drug Design: Relevance and Utility of the Conformationally Sampled Pharmacophore Approach

    PubMed Central

    Acharya, Chayan; Coop, Andrew; Polli, James E.; MacKerell, Alexander D.

    2010-01-01

    In the absence of three-dimensional (3D) structures of potential drug targets, ligand-based drug design is one of the popular approaches for drug discovery and lead optimization. 3D structure-activity relationships (3D QSAR) and pharmacophore modeling are the most important and widely used tools in ligand-based drug design that can provide crucial insights into the nature of the interactions between drug target and ligand molecule and provide predictive models suitable for lead compound optimization. This review article will briefly discuss the features and potential application of recent advances in ligand-based drug design, with emphasis on a detailed description of a novel 3D QSAR method based on the conformationally sample pharmacophore (CSP) approach (denoted CSP-SAR). In addition, data from a published study is used to compare the CSP-SAR approach to the Catalyst method, emphasizing the utility of the CSP approach for ligand-based model development. PMID:20807187

  4. Advanced Endovascular Approaches in the Management of Challenging Proximal Aortic Neck Anatomy: Traditional Endografts and the Snorkel Technique

    PubMed Central

    Quatromoni, Jon G.; Orlova, Ksenia; Foley, Paul J.

    2015-01-01

    Advances in endovascular technology, and access to this technology, have significantly changed the field of vascular surgery. Nowhere is this more apparent than in the treatment of abdominal aortic aneurysms (AAAs), in which endovascular aneurysm repair (EVAR) has replaced the traditional open surgical approach in patients with suitable anatomy. However, approximately one-third of patients presenting with AAAs are deemed ineligible for standard EVAR because of anatomic constraints, the majority of which involve the proximal aneurysmal neck. To overcome these challenges, a bevy of endovascular approaches have been developed to either enhance stent graft fixation at the proximal neck or extend the proximal landing zone to allow adequate apposition to the aortic wall and thus aneurysm exclusion. This article is composed of two sections that together address new endovascular approaches for treating aortic aneurysms with difficult proximal neck anatomy. The first section will explore advancements in the traditional EVAR approach for hostile neck anatomy that maximize the use of the native proximal landing zone; the second section will discuss a technique that was developed to extend the native proximal landing zone and maintain perfusion to vital aortic branches using common, off-the-shelf components: the snorkel technique. While the techniques presented differ in terms of approach, the available clinical data, albeit limited, support the notion that they may both have roles in the treatment algorithm for patients with challenging proximal neck anatomy. PMID:26327748

  5. Advanced Endovascular Approaches in the Management of Challenging Proximal Aortic Neck Anatomy: Traditional Endografts and the Snorkel Technique.

    PubMed

    Quatromoni, Jon G; Orlova, Ksenia; Foley, Paul J

    2015-09-01

    Advances in endovascular technology, and access to this technology, have significantly changed the field of vascular surgery. Nowhere is this more apparent than in the treatment of abdominal aortic aneurysms (AAAs), in which endovascular aneurysm repair (EVAR) has replaced the traditional open surgical approach in patients with suitable anatomy. However, approximately one-third of patients presenting with AAAs are deemed ineligible for standard EVAR because of anatomic constraints, the majority of which involve the proximal aneurysmal neck. To overcome these challenges, a bevy of endovascular approaches have been developed to either enhance stent graft fixation at the proximal neck or extend the proximal landing zone to allow adequate apposition to the aortic wall and thus aneurysm exclusion. This article is composed of two sections that together address new endovascular approaches for treating aortic aneurysms with difficult proximal neck anatomy. The first section will explore advancements in the traditional EVAR approach for hostile neck anatomy that maximize the use of the native proximal landing zone; the second section will discuss a technique that was developed to extend the native proximal landing zone and maintain perfusion to vital aortic branches using common, off-the-shelf components: the snorkel technique. While the techniques presented differ in terms of approach, the available clinical data, albeit limited, support the notion that they may both have roles in the treatment algorithm for patients with challenging proximal neck anatomy.

  6. Advancement of an Infra-Red Technique for Whole-Field Concentration Measurements in Fluidized Beds

    PubMed Central

    Medrano, Jose A.; de Nooijer, Niek C. A.; Gallucci, Fausto; van Sint Annaland, Martin

    2016-01-01

    For a better understanding and description of the mass transport phenomena in dense multiphase gas-solids systems such as fluidized bed reactors, detailed and quantitative experimental data on the concentration profiles is required, which demands advanced non-invasive concentration monitoring techniques with a high spatial and temporal resolution. A novel technique based on the selective detection of a gas component in a gas mixture using infra-red properties has been further developed. The first stage development was carried out using a very small sapphire reactor and CO2 as tracer gas. Although the measuring principle was demonstrated, the real application was hindered by the small reactor dimensions related to the high costs and difficult handling of large sapphire plates. In this study, a new system has been developed, that allows working at much larger scales and yet with higher resolution. In the new system, propane is used as tracer gas and quartz as reactor material. In this study, a thorough optimization and calibration of the technique is presented which is subsequently applied for whole-field measurements with high temporal resolution. The developed technique allows the use of a relatively inexpensive configuration for the measurement of detailed concentration fields and can be applied to a large variety of important chemical engineering topics. PMID:26927127

  7. An integrated approach for prioritizing pharmaceuticals found in the environment for risk assessment, monitoring and advanced research.

    PubMed

    Caldwell, Daniel J; Mastrocco, Frank; Margiotta-Casaluci, Luigi; Brooks, Bryan W

    2014-11-01

    Numerous active pharmaceutical ingredients (APIs), approved prior to enactment of detailed environmental risk assessment (ERA) guidance in the EU in 2006, have been detected in surface waters as a result of advancements in analytical technologies. Without adequate knowledge of the potential hazards these APIs may pose, assessing their environmental risk is challenging. As it would be impractical to commence hazard characterization and ERA en masse, several approaches to prioritizing substances for further attention have been published. Here, through the combination of three presentations given at a recent conference, "Pharmaceuticals in the Environment, Is there a problem?" (Nîmes, France, June 2013) we review several of these approaches, identify salient components, and present available techniques and tools that could facilitate a pragmatic, scientifically sound approach to prioritizing APIs for advanced study or ERA and, where warranted, fill critical data gaps through targeted, intelligent testing. We further present a modest proposal to facilitate future prioritization efforts and advanced research studies that incorporates mammalian pharmacology data (e.g., adverse outcomes pathways and the fish plasma model) and modeled exposure data based on pharmaceutical use. PMID:24636702

  8. Thermal Conductivity of Advanced Ceramic Thermal Barrier Coatings Determined by a Steady-state Laser Heat-flux Approach

    NASA Technical Reports Server (NTRS)

    Zhu, Dong-Ming; Miller, Robert A.

    2004-01-01

    The development of low conductivity and high temperature capable thermal barrier coatings requires advanced testing techniques that can accurately and effectively evaluate coating thermal conductivity under future high-performance and low-emission engine heat-flux conditions. In this paper, a unique steady-state CO2 laser (wavelength 10.6 microns) heat-flux approach is described for determining the thermal conductivity and conductivity deduced cyclic durability of ceramic thermal and environmental barrier coating systems at very high temperatures (up to 1700 C) under large thermal gradients. The thermal conductivity behavior of advanced thermal and environmental barrier coatings for metallic and Si-based ceramic matrix composite (CMC) component applications has also been investigated using the laser conductivity approach. The relationships between the lattice and radiation conductivities as a function of heat flux and thermal gradient at high temperatures have been examined for the ceramic coating systems. The steady-state laser heat-flux conductivity approach has been demonstrated as a viable means for the development and life prediction of advanced thermal barrier coatings for future turbine engine applications.

  9. Measuring Habituation in Infants: An Approach Using Regression Analysis.

    ERIC Educational Resources Information Center

    Ashmead, Daniel H.; Davis, DeFord L.

    1996-01-01

    Used computer simulations to examine effectiveness of different criteria for measuring infant visual habituation. Found that a criterion based on fitting a second-order polynomial regression function to looking-time data produced more accurate estimation of looking times and higher power for detecting novelty effects than did the traditional…

  10. An Approach to the Measurement of Preschool Environments.

    ERIC Educational Resources Information Center

    Klein, Robert P.

    The general method of observation of education for preschool children, and the conceptual dimensions underlying the categories of experience are discussed. The technique used for measuring preschool experience is the Inventory of Children's Preschool Experience (ICPE). The scale provides a description of the experiences of specific children in the…

  11. "Measurement Monday": one facility's approach to standardizing skin impairment documentation.

    PubMed

    Stewart, Suzanne; Bennett, Sally; Blokzyl, Angela; Bowman, Winnie; Butcher, Ida; Chapman, Kelly; Koop, Kelly; Lebo, Barb; Siebecker, Diane; Signs, Heidi; Streeter, Jane; Russo, Catherine; Wenzel, Susan

    2009-12-01

    Accurate, timely wound assessment and documentation is fundamental to nursing practice. A 2005 retrospective chart audit (N = 54) at a rural, 238-bed tertiary care facility in Northeastern Pennsylvania (average daily census 175 to 180) found that complete wound assessment documentation (including measurements) was lacking in 59% of patient charts. The purpose of this quality improvement initiative, led by the Wound Ostomy Continence Nurse (WOCN), was to evaluate and improve nursing assessment and documentation of impaired skin (pressure ulcers, skin tears, open surgical wounds, diabetic ulcers, and venous stasis ulcers). A review of the literature confirmed the importance of consistency, which led to the hospital-wide implementation of education programs and "Measurement Monday." Using AHCPR guidelines of care for pressure ulcers and beginning in January 2006 all wounds were assessed and measured every Monday and the proportion of incomplete charts declined to 38%. Following addition of a wound documentation tool in 2007, the proportion of incomplete records was 14.8%. This quality improvement initiative improved the quality and consistency of wound assessment/measurement and documentation. PMID:20038791

  12. Suggested Approaches to the Measurement of Computer Anxiety.

    ERIC Educational Resources Information Center

    Toris, Carol

    Psychologists can gain insight into human behavior by examining what people feel about, know about, and do with, computers. Two extreme reactions to computers are computer phobia, or anxiety, and computer addiction, or "hacking". A four-part questionnaire was developed to measure computer anxiety. The first part is a projective technique which…

  13. Measuring Afterschool Program Quality Using Setting-Level Observational Approaches

    ERIC Educational Resources Information Center

    Oh, Yoonkyung; Osgood, D. Wayne; Smith, Emilie P.

    2015-01-01

    The importance of afterschool hours for youth development is widely acknowledged, and afterschool settings have recently received increasing attention as an important venue for youth interventions, bringing a growing need for reliable and valid measures of afterschool quality. This study examined the extent to which the two observational tools,…

  14. Traditional versus Computer-Mediated Approaches of Teaching Educational Measurement

    ERIC Educational Resources Information Center

    Alkharusi, Hussain; Kazem, Ali; Al-Musawai, Ali

    2010-01-01

    Research suggests that to adequately prepare teachers for the task of classroom assessment, attention should be given to the educational measurement instruction. In addition, the literature indicates that the use of computer-mediated instruction has the potential to affect student knowledge, skills, and attitudes. This study compared the effects…

  15. Design of psychosocial factors questionnaires: a systematic measurement approach

    PubMed Central

    Vargas, Angélica; Felknor, Sarah A

    2012-01-01

    Background Evaluation of psychosocial factors requires instruments that measure dynamic complexities. This study explains the design of a set of questionnaires to evaluate work and non-work psychosocial risk factors for stress-related illnesses. Methods The measurement model was based on a review of literature. Content validity was performed by experts and cognitive interviews. Pilot testing was carried out with a convenience sample of 132 workers. Cronbach’s alpha evaluated internal consistency and concurrent validity was estimated by Spearman correlation coefficients. Results Three questionnaires were constructed to evaluate exposure to work and non-work risk factors. Content validity improved the questionnaires coherence with the measurement model. Internal consistency was adequate (α=0.85–0.95). Concurrent validity resulted in moderate correlations of psychosocial factors with stress symptoms. Conclusions Questionnaires´ content reflected a wide spectrum of psychosocial factors sources. Cognitive interviews improved understanding of questions and dimensions. The structure of the measurement model was confirmed. PMID:22628068

  16. Corruption in Higher Education: Conceptual Approaches and Measurement Techniques

    ERIC Educational Resources Information Center

    Osipian, Ararat L.

    2007-01-01

    Corruption is a complex and multifaceted phenomenon. Forms of corruption are multiple. Measuring corruption is necessary not only for getting ideas about the scale and scope of the problem, but for making simple comparisons between the countries and conducting comparative analysis of corruption. While the total impact of corruption is indeed…

  17. Approaches to Measuring and Understanding Employer Training Expenditure

    ERIC Educational Resources Information Center

    Smith, Andrew; Burke, Gerald; Long, Michael; Dumbrell, Tom

    2008-01-01

    While it is recognised that employers invest a substantial amount of money and time in training, the exact nature and amount of this investment is poorly measured and understood. This project set out to supplement the available data, which have many limitations, with more detailed data for selected industries. However, it became quickly apparent…

  18. Joseph F. Keithley Award For Advances in Measurement Science: Resonant Ultrasound Spectroscopy: An Odyssey in Measurement Science

    NASA Astrophysics Data System (ADS)

    Migliori, Albert

    Perhaps the speeds of sound, or, equivalently, the elastic moduli are some of the most fundamental attributes of a solid, connecting to fundamental physics, metallurgy, non-destructive testing, and more. Unlike most of the quantities used to characterize condensed matter, the elastic moduli are fourth-rank tensors containing a wealth of detail, directional information, and consistency constraints that provide some of the most revealing probes of solids. We describe here the current state of the art in one method, Resonant Ultrasound Spectroscopy, where the mechanical resonances of a specimen of regular shape (easy to measure) are analyzed (difficult computational problem) to obtain the full elastic tensor. With modern advances in electronics and analysis, fractions of a part per million changes in elastic moduli are detectable providing new and important insight into grand challenges in condensed matter physics. This work was supported as part of the Materials Science of Actinides, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Basic Energy Sciences under Award # DE-SC0001089.

  19. Rapid measurements of intensities for safety assessment of advanced imaging sequences

    NASA Astrophysics Data System (ADS)

    Jensen, Jørgen Arendt; Rasmussen, Morten Fischer; Stuart, Matthias Bo; Tomov, Borislav G.

    2014-03-01

    FDA requires that intensity and safety parameters are measured for all imaging schemes for clinical imaging. This is often cumbersome, since the scan sequence has to broken apart, measurements conducted for the individually emitted beams, and the final intensity levels calculated by combining the intensities from the individual beams. This paper suggests a fast measurement scheme using the multi-line sampling capability of modern scanners and research systems. The hydrophone is connected to one sampling channel in the research system, and the intensity is measured for all imaging lines in one emission sequence. This makes it possible to map out the pressure field and hence intensity level for all imaging lines in a single measurement. The approach has several advantages: the scanner does not have to be re-programmed and can use the scan sequence without modification. The measurements are orders of magnitude faster (minutes rather than hours) and the final intensity level calculation can be made generic and reused for any kind of scan sequence by just knowing the number of imaging lines and the pulse repetition time. The scheme has been implemented on the Acoustic Intensity Measurement System AIMS III (Onda, Sunnyvale, California, USA). The research scanner SARUS is used for the experiments, where one of the channels is used for the hydrophone signal. A 3 MHz BK 8820e (BK Medical, Herlev, Denmark) convex array with 192 elements is used along with an Onda HFL-0400 hydrophone connected to a AH-2010 pre-amplifier (Onda Corporation, Sunnyvale, USA). A single emission sequence is employed for testing and calibrating the approach. The measurements using the AIMS III and SARUS systems after calibration agree within a relative standard deviation of 0.24%. A duplex B-mode and flow sequence is also investigated. The complex intensity map is measured and the time averaged spatial peak intensity is found. A single point measurement takes 3.43 seconds and the whole sequence can

  20. Improved equilibrium reconstructions by advanced statistical weighting of the internal magnetic measurements

    NASA Astrophysics Data System (ADS)

    Murari, A.; Gelfusa, M.; Peluso, E.; Gaudio, P.; Mazon, D.; Hawkes, N.; Point, G.; Alper, B.; Eich, T.

    2014-12-01

    In a Tokamak the configuration of the magnetic fields remains the key element to improve performance and to maximise the scientific exploitation of the device. On the other hand, the quality of the reconstructed fields depends crucially on the measurements available. Traditionally in the least square minimisation phase of the algorithms, used to obtain the magnetic field topology, all the diagnostics are given the same weights, a part from a corrective factor taking into account the error bars. This assumption unduly penalises complex diagnostics, such as polarimetry, which have a limited number of highly significant measurements. A completely new method to choose the weights, to be given to the internal measurements of the magnetic fields for improved equilibrium reconstructions, is presented in this paper. The approach is based on various statistical indicators applied to the residuals, the difference between the actual measurements and their estimates from the reconstructed equilibrium. The potential of the method is exemplified using the measurements of the Faraday rotation derived from JET polarimeter. The results indicate quite clearly that the weights have to be determined carefully, since the inappropriate choice can have significant repercussions on the quality of the magnetic reconstruction both in the edge and in the core. These results confirm the limitations of the assumption that all the diagnostics have to be given the same weight, irrespective of the number of measurements they provide and the region of the plasma they probe.

  1. A comparison of the generalized estimating equation approach with the maximum likelihood approach for repeated measurements.

    PubMed

    Park, T

    1993-09-30

    Liang and Zeger proposed an extension of generalized linear models to the analysis of longitudinal data. Their approach is closely related to quasi-likelihood methods and can handle both normal and non-normal outcome variables such as Poisson or binary outcomes. Their approach, however, has been applied mainly to non-normal outcome variables. This is probably due to the fact that there is a large class of multivariate linear models available for normal outcomes such as growth models and random-effects models. Furthermore, there are many iterative algorithms that yield maximum likelihood estimators (MLEs) of the model parameters. The multivariate linear model approach, based on maximum likelihood (ML) estimation, specifies the joint multivariate normal distribution of outcome variables while the approach of Liang and Zeger, based on the quasi-likelihood, specifies only the marginal distributions. In this paper, I compare the approach of Liang and Zeger and the ML approach for the multivariate normal outcomes. I show that the generalized estimating equation (GEE) reduces to the score equation only when the data do not have missing observations and the correlation is unstructured. In more general cases, however, the GEE estimation yields consistent estimators that may differ from the MLEs. That is, the GEE does not always reduce to the score equation even when the outcome variables are multivariate normal. I compare the small sample properties of the GEE estimators and the MLEs by means of a Monte Carlo simulation study. PMID:8248664

  2. Statistical approach for subwavelength measurements with a conventional light microscope

    PubMed Central

    Palanker, Daniel; Lewis, Aaron

    1991-01-01

    A method is developed theoretically that will permit subwavelength measurements of objects that differ from the surroundings by any contrast enhancing parameter, such as fluorescence, second harmonic generation, reflection et cetera, using a statistical analysis of a picture obtained with a conventional light microscope through a set of subwavelength apertures or by repeated scanning of a laser beam over a defined area. It is demonstrated that with this methodology information can be obtained on microdomains that are thirty times less than the diameter of the aperture. For example, for apertures that are 0.3 μm in diameter it is possible to measure the dimension of objects that are ∼10 nm. A technology is described by which it is possible to produce masks with the appropriate apertures. Instrumentation is described that would allow for the realization of these statistical methodologies with either apertures or scanning laser beams. ImagesFIGURE 2FIGURE 6FIGURE 7 PMID:19431808

  3. Measuring afterschool program quality using setting-level observational approaches

    PubMed Central

    Oh, Yoonkyung; Osgood, D. Wayne; Smith, Emilie Phillips

    2016-01-01

    As the importance of afterschool hours for youth development is widely acknowledged, afterschool settings have recently received increasing attention as an important venue for youth interventions. A range of intervention programs have been in place, generally aiming at positive youth development through enhancing the quality of programs. A growing need has thus arisen for reliable and valid measures of afterschool quality. This study examined the extent to which the two observational tools, i.e., Caregiver Interaction Scales (CIS) and Promising Practices Rating Scales (PPRS), could serve as reliable and valid tools for assessing the various dimensions of afterschool setting quality. The study shows the potential promise of the instruments, on the one hand, and suggests future directions for improvement of measurement design and development of the field, on the other hand. In particular, our findings suggest the importance of addressing the effect of day-to-day fluctuations in observed afterschool quality. PMID:26819487

  4. Visceral Leishmaniasis: Advancements in Vaccine Development via Classical and Molecular Approaches

    PubMed Central

    Joshi, Sumit; Rawat, Keerti; Yadav, Narendra Kumar; Kumar, Vikash; Siddiqi, Mohammad Imran; Dube, Anuradha

    2014-01-01

    Visceral leishmaniasis (VL) or kala-azar, a vector-borne protozoan disease, shows endemicity in larger areas of the tropical, subtropical and the Mediterranean countries. WHO report suggested that an annual incidence of VL is nearly 200,000 to 400,000 cases, resulting in 20,000 to 30,000 deaths per year. Treatment with available anti-leishmanial drugs are not cost effective, with varied efficacies and higher relapse rate, which poses a major challenge to current kala-azar control program in Indian subcontinent. Therefore, a vaccine against VL is imperative and knowing the fact that recovered individuals developed lifelong immunity against re-infection, it is feasible. Vaccine development program, though time taking, has recently gained momentum with the emergence of omic era, i.e., from genomics to immunomics. Classical as well as molecular methodologies have been overtaken with alternative strategies wherein proteomics based knowledge combined with computational techniques (immunoinformatics) speed up the identification and detailed characterization of new antigens for potential vaccine candidates. This may eventually help in the designing of polyvalent synthetic and recombinant chimeric vaccines as an effective intervention measures to control the disease in endemic areas. This review focuses on such newer approaches being utilized for vaccine development against VL. PMID:25202307

  5. Mask CD measurement approach by diffraction intensity for lithography equivalent

    NASA Astrophysics Data System (ADS)

    Nagai, Takaharu; Mesuda, Kei; Sutou, Takanori; Inazuki, Yuichi; Hashimoto, Hiroyuki; Yokoyama, Toshifumi; Toyama, Nobuhito; Morikawa, Yasutaka; Mohri, Hiroshi; Hayashi, Naoya

    2008-04-01

    In 45nm node and beyond with hyper NA lithography, mask topography effect is not ignorable and mask CD bias impacts printing performance such as MEEF or exposure latitude. In that situation, 3D simulation is required for precise evaluation of printing performance and the accuracy of 3D mask model on simulation is a key issue. Verification of 3D mask model by diffraction intensity measurement with AIMS TM45-193i was discussed in our previous works. Through the verification, though real mask successfully creates effective or simulated diffractions, CD on 3D mask model on simulation was different to that on AIMS TM result which was measured by CD-SEM. Therefore, purpose of this work is to analyze the cause of CD differences through AIMS TM diffraction intensity evaluation in various conditions (mask material, pattern pitch, mask CD bias and mask CD-SEM system). Furthermore, lithography equivalent CD is proposed as width of "ideal" mask shape. As a result achieved from the experiments, constant CD shift was successfully observed at hp40-70nm L/S pattern with varied bias for both 6% EAPSM and Binary masks. It can be said that mask topography difference related to mask material and pattern dimensions has not been observed. On the other hand, the value of CD shift was smaller on the condition of newer generation CD-SEM measurement. Other result achieved from further discussion and analysis, cause of the CD difference was explained using simple SEM image simulation. The CD difference was mainly changed by electron beam size factor, and it was stable with side wall angle in the range of 80 to 90 degree if the middle CD, which is the width of 3D model defined at the half height of the mask film's thickness, is constant. Since side wall angles on actual masks are nearly 90 degree, lithography equivalent CD could be measured by CD-SEM with constant offset.

  6. A microwave systems approach to measuring root zone soil moisture

    NASA Technical Reports Server (NTRS)

    Newton, R. W.; Paris, J. F.; Clark, B. V.

    1983-01-01

    Computer microwave satellite simulation models were developed and the program was used to test the ability of a coarse resolution passive microwave sensor to measure soil moisture over large areas, and to evaluate the effect of heterogeneous ground covers with the resolution cell on the accuracy of the soil moisture estimate. The use of realistic scenes containing only 10% to 15% bare soil and significant vegetation made it possible to observe a 60% K decrease in brightness temperature from a 5% soil moisture to a 35% soil moisture at a 21 cm microwave wavelength, providing a 1.5 K to 2 K per percent soil moisture sensitivity to soil moisture. It was shown that resolution does not affect the basic ability to measure soil moisture with a microwave radiometer system. Experimental microwave and ground field data were acquired for developing and testing a root zone soil moisture prediction algorithm. The experimental measurements demonstrated that the depth of penetration at a 21 cm microwave wavelength is not greater than 5 cm.

  7. Numerical simulations of a new approach for seeing measurement

    NASA Astrophysics Data System (ADS)

    Habib, A.; Benkhaldoun, Z.; El Azhari, Y.

    2013-09-01

    Using a numerical simulation, a new approach to determine the wave structure function, and therefore the astronomical seeing, is presented and discussed. This method is based on the study of the diffraction pattern produced by a double slit at the focus plane of a telescope. The phase screens are simulated using a fast Fourier transform (FFT) based method and Kolmogorov's law regarding atmospheric turbulence. From the scattered wave intensity, the wave structure function is calculated by taking into account both phase and amplitude fluctuations. This means that we can obtain a seeing value that is independent of the propagation distance between the turbulent layers and the ground level (Fresnel diffraction effect). Indeed, the seeing is related to the refractive-index structure constant (Cn2) inside the turbulent layers and thus should be independent of the aforementioned propagation distance.

  8. Measuring geographic segregation: a graph-based approach

    NASA Astrophysics Data System (ADS)

    Hong, Seong-Yun; Sadahiro, Yukio

    2014-04-01

    Residential segregation is a multidimensional phenomenon that encompasses several conceptually distinct aspects of geographical separation between populations. While various indices have been developed as a response to different definitions of segregation, the reliance on such single-figure indices could oversimplify the complex, multidimensional phenomena. In this regard, this paper suggests an alternative graph-based approach that provides more detailed information than simple indices: The concentration profile graphically conveys information about how evenly a population group is distributed over the study region, and the spatial proximity profile depicts the degree of clustering across different threshold levels. These graphs can also be summarized into single numbers for comparative purposes, but the interpretation can be more accurate by inspecting the additional information. To demonstrate the use of these methods, the residential patterns of three major ethnic groups in Auckland, namely Māori, Pacific peoples, and Asians, are examined using the 2006 census data.

  9. A multiple-plane approach to measure the structural properties of functionally active regions in the human cortex.

    PubMed

    Wang, Xin; Garfinkel, Sarah N; King, Anthony P; Angstadt, Mike; Dennis, Michael J; Xie, Hong; Welsh, Robert C; Tamburrino, Marijo B; Liberzon, Israel

    2010-02-15

    Advanced magnetic resonance imaging (MRI) techniques provide the means of studying both the structural and the functional properties of various brain regions, allowing us to address the relationship between the structural changes in human brain regions and the activity of these regions. However, analytical approaches combining functional (fMRI) and structural (sMRI) information are still far from optimal. In order to improve the accuracy of measurement of structural properties in active regions, the current study tested a new analytical approach that repeated a surface-based analysis at multiple planes crossing different depths of cortex. Twelve subjects underwent a fear conditioning study. During these tasks, fMRI and sMRI scans were acquired. The fMRI images were carefully registered to the sMRI images with an additional correction for cortical borders. The fMRI images were then analyzed with the new multiple-plane surface-based approach as compared to the volume-based approach, and the cortical thickness and volume of an active region were measured. The results suggested (1) using an additional correction for cortical borders and an intermediate template image produced an acceptable registration of fMRI and sMRI images; (2) surface-based analysis at multiple depths of cortex revealed more activity than the same analysis at any single depth; (3) projection of active surface vertices in a ribbon fashion improved active volume estimates; and (4) correction with gray matter segmentation removed non-cortical regions from the volumetric measurement of active regions. In conclusion, the new multiple-plane surface-based analysis approaches produce improved measurement of cortical thickness and volume of active brain regions. These results support the use of novel approaches for combined analysis of functional and structural neuroimaging. PMID:19922802

  10. Using Rasch Measurement Theory to Examine Two Instructional Approaches for Teaching and Learning of French Grammar

    ERIC Educational Resources Information Center

    Vogel, Severine P.; Engelhard, George, Jr.

    2011-01-01

    The authors describe a quantitative approach based on Rasch measurement theory for evaluating classroom assessments within the context of foreign language classes. A secondary purpose was to examine the effects of two instructional approaches to teach grammar, a guided inductive and a deductive approach, through the lens of Rasch measurement…

  11. A Comparison of Two Approaches for Measuring Educational Growth from CTBS and P-ACT+ Scores.

    ERIC Educational Resources Information Center

    Noble, Julie; Sawyer, Richard

    The purpose of the study was to compare two regression-based approaches for measuring educational effectiveness in Tennessee high schools: the mean residual approach (MR), and a more general linear models (LM) approach. Data were obtained from a sample of 1,011 students who were enrolled in 48 high schools, and who had taken the Comprehensive…

  12. Modern Measurement Approaches to Health Literacy Scale Development and Refinement: Overview, Current Uses, and Next Steps.

    PubMed

    Nguyen, Tam H; Paasche-Orlow, Michael K; Kim, Miyong T; Han, Hae-Ra; Chan, Kitty S

    2015-01-01

    There are currently more than 100 health literacy instruments. The procedures used to develop and test the measures are primarily guided by classical test theory. However, a small and growing number (n = 13) of health literacy measures are guided by modern measurement theories such as item response theory. This article briefly describes (a) the benefits of using modern measurement approaches for the development of health literacy measures, (b) how these approaches have been used with existing health literacy measures, and (c) some considerations for how modern measurement theory can help strengthen future work in health literacy measurement. Ultimately, this article provides evidence to support an assertive shift toward the use of modern measurement approaches in health literacy instrument development. PMID:26513038

  13. Pictorial approaches for measuring time use in rural Ethiopia

    PubMed Central

    Masuda, Yuta J.; Fortmann, Lea; Gugerty, Mary Kay; Smith-Nilson, Marla; Cook, Joseph

    2014-01-01

    Time use researchers working in least developed countries (LDCs) face difficulties collecting data from illiterate populations who may conceptualize time differently than those in industrialized countries. We identify existing gaps in time use data collection methods and discuss two novel, pictorial methods to collect time use data from these populations. The first method is a modified recall interview modeled on participatory rural appraisal (PRA) methods that asks respondents to place macaroni on pictures of activity categories in proportion to the amount of time spent on that activity during the previous day. The second is a simplified pictorial time diary that uses a timer and sequentially-numbered stickers to re-create the temporal order of activities in 30-minute increments. The latter method also avoids recall bias problems. We present time use data collected in 2009 using these methods in a study examining the impacts of water infrastructure on women and children’s time use in rural Ethiopia. In total, we collected information using the first method from 263 household members over age 10, including 167 water collectors, and pilot-tested the pictorial diary approach with 10 adult respondents. PMID:25620832

  14. Rapid development of a measurement and control system for the Advanced Free-Electron Laser

    SciTech Connect

    Wilson, W.L. Jr.; May, M.W.; Kozubal, A.J.

    1991-01-01

    The Experimental Physics and Industrial Control System (EPICS) is being used to develop a measurement and control system for the Advanced Free-Electron laser (AFEL) at the Los Alamos National Laboratory. EPICS is an integrated system of applications development tools and a distributed run time environment that supports an input-output database, a graphical operator interface, sequential control through state'' definition, data archiving, data analysis, and fault management. It is very advantageous in terms of both time and system integrity to be able to perform much of the control system development before the actual hardware for the AFEL is in place. Using the EPICS applications tools, we are developing prototype measurements and controls that can be directly transferred to the AFEL during installation and commissioning. This is possible due primarily to three aspects of EPICS. First we can easily model physical systems with the state notation language. Second, we can simulate input and output channels with soft'' database channels, which are created using the database configuration tool. Third, we can easily build and modify operator interface screens with the display editor. 8 refs., 3 figs.

  15. Internal Acoustics Measurements of a Full Scale Advanced Ducted Propulsor Demonstrator

    NASA Technical Reports Server (NTRS)

    Santa Maria, O. L.; Soderman, P. T.; Horne, W. C.; Jones, M. G.; Bock, L. A.

    1995-01-01

    Acoustics measurements of a Pratt & Whitney full-scale ADP (Advanced Ducted Propulsor), an ultrahigh by-pass ratio engine, were conducted in the NASA Ames 40- by 80-Foot Wind Tunnel. This paper presents data from measurements taken from sensors on a fan exit guide vane in the ADP. Data from two sensors, one at mid-span and the other at the tip of the fan exit guide vane, are presented. At the blade passage frequency (BPF), the levels observed at the various engine and wind speeds were higher at the mid-span sensor than the tip sensor. The coherence between these internal sensors and external microphones were calculated and plotted as a function of angle (angles ranged from 5 degrees to 160 degrees) relative to the ADP longitudinal axis. At the highest engine and wind speeds, the coherence between the tip sensor and the external microphones was observed to decrease at higher multiples of the BPF. These results suggest that the rotor-stator interaction tones are stronger in the mid-span region than at the tip.

  16. Photon stimulated desorption measurement of an extruded aluminum beam chamber for the Advanced Photon Source

    SciTech Connect

    Foerster, C.L.; Lanni, C.; Noonan, J.R.; Rosenberg, R.A.

    1995-12-31

    The Advanced Photon Source (APS), presently being commisioned, will produce X-ray s of unprecedented brightness. The high energy ring of the APS is a 7 GeV positron storage ring, 1104 meters in circumference designed to operate at less than 10{sup {minus}9} Torr with 300 ma of beam and a greater than 10 hour lifetime. The storage ring vacuum chamber is constructed from an extruded 6063 aluminum alloy. During the construction phase, a 2.34 m long section of the APS extruded aluminum chamber was set up on National Synchrotron Light Source (NSLS) X-ray Beamlline X28A and Photon Stimulated Desorption (PSD) was measured. Cleaning and preparation of the chamber was identical to that of the APS construction. In addition to the chamber, small samples of M, Be, and Cu were also exposed to white light having a critical energy of 5 keV. In addition to PSD, measurements were made of specular and diffuse scattering of photons. The chamber and samples were each exposed to a dose greater than 10{sup 23} photons per meter. Desorption yields for H{sub 2}, CO, CO{sub 2}, CH{sub 4} and H{sub 2}0 are reported as a function of accumulated flux, critical energy, incidence angle, and preparation. These results are compared with previous results for aluminum on NSLS Beamlline U1OB and PSD results of other laboratories published for aluminum.

  17. 2-Micron Coherent Doppler Lidar Instrument Advancements for Tropospheric Wind Measurement

    NASA Technical Reports Server (NTRS)

    Petros, Mulugeta; Singh, U. N.; Yu, J.; Kavaya, M. J.; Koch, G.

    2014-01-01

    Knowledge derived from global tropospheric wind measurement is an important constituent of our overall understanding of climate behavior [1]. Accurate weather prediction saves lives and protects properties from destructions. High-energy 2-micron laser is the transmitter of choice for coherent Doppler wind detection. In addition to the eye-safety, the wavelength of the transmitter suitably matches the aerosol size in the lower troposphere. Although the technology of the 2-micron laser has been maturing steadily, lidar derived wind data is still a void in the global weather database. In the last decade, researchers at NASA Langley Research Center (LaRC) have been engaged in this endeavor, contributing to the scientific database of 2-micron lidar transmitters. As part of this effort, an in depth analysis of the physics involved in the workings of the Ho: Tm laser systems have been published. In the last few years, we have demonstrated lidar transmitter with over1Joule output energy. In addition, a large body of work has been done in characterizing new laser materials and unique crystal configurations to enhance the efficiency and output energy of the 2-micron laser systems. At present 2-micron lidar systems are measuring wind from both ground and airborne platforms. This paper will provide an overview of the advancements made in recent years and the technology maturity levels attained.

  18. X-ray beam size measurements on the Advanced Test Accelerator

    SciTech Connect

    Struve, K.W.; Chambers, F.W.; Lauer, E.J.; Slaughter, D.R.

    1986-01-01

    The electron beam size has been determined on the Advanced Test Accelerator (ATA) by intercepting the beam with a target and measuring the resulting x-ray intensity as a function of time as the target is moved through the beam. Several types of targets have been used. One is a tantalum rod which extends completely across the drift chamber. Another is a tungsten powder filled carbon crucible. Both of these probes are moved from shot to shot so that the x-ray signal intensity varies with probe position. A third is a larger tantalum disk which is inserted on beam axis to allow determining beam size on a one shot basis. The x-ray signals are detected with an MCP photomultiplier tube located at 90/sup 0/ to the beamline. It is sufficiently shielded to reject background x-rays and neutrons. The signals were digitized, recorded and later unfolded to produce plots of x-ray intensity versus probe position for several times during the pulse. The presumption that the x-ray intensity is proportional to beam current density is checked computationally. Details of the probe construction and PMT shielding, as well as sample measurements are given.

  19. Measuring engagement in advance care planning: a cross-sectional multicentre feasibility study

    PubMed Central

    Howard, Michelle; Bonham, Aaron J; Heyland, Daren K; Sudore, Rebecca; Fassbender, Konrad; Robinson, Carole A; McKenzie, Michael; Elston, Dawn; You, John J

    2016-01-01

    Objectives To assess the feasibility, acceptability and clinical sensibility of a novel survey, the advance care planning (ACP) Engagement Survey, in various healthcare settings. Setting A target sample of 50 patients from each of primary care, hospital, cancer care and dialysis care settings. Participants A convenience sample of patients without cognitive impairment who could speak and read English was recruited. Patients 50 and older were eligible in primary care; patients 80 and older or 55 and older with clinical markers of advanced chronic disease were recruited in hospital; patients aged 19 and older were recruited in cancer and renal dialysis centres. Outcomes We assessed feasibility, acceptability and clinical sensibility of the ACP Engagement Survey using a 6-point scale. The ACP Engagement Survey measures ACP processes (knowledge, contemplation, self-efficacy and readiness) on 5-point Likert scales and actions (yes/no). Results 196 patients (38–96 years old, 50.5% women) participated. Mean (±SD) time to administer was 48.8±19.6 min. Mean acceptability scores ranged from 3.2±1.3 in hospital to 4.7±0.9 in primary care, and mean relevance ranged from 3.5±1.0 in hospital to 4.9±0.9 in dialysis centres (p<0.001 for both). The mean process score was 3.1±0.6 and the mean action score was 11.2±5.6 (of a possible 25). Conclusions The ACP Engagement Survey demonstrated feasibility and acceptability in outpatient settings but was less feasible and acceptable among hospitalised patients due to length. A shorter version may improve feasibility. Engagement in ACP was low to moderate. PMID:27338877

  20. Advances in technologies for the measurement of uranium in diverse matrices.

    PubMed

    Rathore, D P S

    2008-10-19

    An overview of the advances in technologies, which can be used in the field as well as in a laboratory for the measurement of uranium in diverse matrices like, waters, minerals, mineralized rocks, and other beneficiation products for its exploration and processing industries is presented. Laser based technologies, ion chromatography, microsample X-ray analysis method followed by energy dispersive X-ray fluorescence technique (MXA-EDXRF), sensors for electrochemical detection followed by cyclic voltammogram and alpha liquid scintillation counting techniques are the most promising techniques. Among these techniques, laser fluorimetry/spectrofluorimetry, in particular, is the technique of choice because of its high performance qualification (PQ), inherent sensitivity, simplicity, cost effectiveness, minimum generation of analytical waste, rapidity, easy calibration and operation. It also fulfills the basic essential requirements of reliability, applicability and practicability (RAPs) for the analysis of uranium in solution of diverse matrices in entire nuclear fuel cycle. A very extensive range of uranium concentrations may be covered. Laser fluorimetry is suitable for direct determination of uranium in natural water systems within the microg L(-1) and mg L(-1) range while differential technique in laser fluorimetry (DT-LIF) is suitable for mineralized rocks and concentrates independent of matrix effects (uranium in samples containing >0.01% uranium). The most interesting feature of TRLIF is its capability of performing speciation of complexes directly in solution as well as remote determination via fiber optics and optrode. Future trend and advances in lasers, miniaturization and automation via flow injection analysis (FIA) has been discussed. PMID:18804592

  1. Advancing a Complex Systems Approach to Personalized Learning Communities: Bandwidth, Sightlines, and Teacher Generativity

    ERIC Educational Resources Information Center

    Hamilton, Eric

    2015-01-01

    Educational technologies have advanced one of the most important visions of educational reformers, to customize formal and informal learning to individuals. The application of a complex systems framework to the design of learning ecologies suggests that each of a series of ten desirable and malleable features stimulates or propels the other ten,…

  2. Development of cost effective fenceline monitoring approaches to support advanced leak detection and repair strategies

    EPA Science Inventory

    Cost-effective fence line and process monitoring systems to support advanced leak detection and repair (LDAR) strategies can enhance protection of public health, facilitate worker safety, and help companies realize cost savings by reducing lost product. The U.S. EPA Office of Re...

  3. Synthesis of an Advanced Intermediate of the Jatrophane Diterpene Pl-4: A Dibromide Coupling Approach

    PubMed Central

    2013-01-01

    The preparation of an advanced intermediate toward the synthesis of the jatrophane diterpene Pl-4 is described. The key step is a regioselective chelation-controlled lithiation of the (Z)-configured bromide in the corresponding vinyl dibromide precursor. The method outlined within this Article is suitable for the facile access of sterically hindered internal vinyl halides for further coupling reactions. PMID:23895274

  4. The Biopsychosocial Approach to Chronic Pain: Scientific Advances and Future Directions

    ERIC Educational Resources Information Center

    Gatchel, Robert J.; Peng, Yuan Bo; Peters, Madelon L.; Fuchs, Perry N.; Turk, Dennis C.

    2007-01-01

    The prevalence and cost of chronic pain is a major physical and mental health care problem in the United States today. As a result, there has been a recent explosion of research on chronic pain, with significant advances in better understanding its etiology, assessment, and treatment. The purpose of the present article is to provide a review of…

  5. Government/industry partnership: A revolutionary approach in global leadership of advanced gas turbines

    SciTech Connect

    Ali, S.A.; Zeh, C.M.

    1996-02-01

    The U.S. Department of Energy (DOE) has established a government/industry partnership program to greatly improve the capabilities of U.S. gas turbine technology. A new and challenging program named the Advanced Turbine Systems Program (ATS) has been initiated by DOE. The technical and business objectives of this initiative are to challenge the bounds of high performance capabilities of gas turbines, meet stringent environmental requirements, and produce lower cost electric power and cogeneration steam. This program will also yield greater societal benefits through continued expansion of high skilled U.S. jobs and export of U.S. products world wide. A progress report on the ATS program pertaining to program status at DOE will be presented and reviewed in this paper. A preliminary design of an industrial advanced turbine system configuration will also be outlined in the paper. The technical challenges; advanced critical technologies incorporation, analytical and experimental solutions, and test results of an advanced gas turbine meeting the DOE goals will be described and discussed.

  6. An Empirical Grounded Theory Approach to Characterizing Advanced Mathematical Thinking in College Calculus

    ERIC Educational Resources Information Center

    Nabb, Keith A.

    2013-01-01

    The research literature has made calls for greater coherence and consistency with regard to the meaning and use of the term advanced mathematical thinking (AMT) in mathematics education (Artigue, Batanero, & Kent, 2007; Selden & Selden, 2005). Educators and researchers agree that students should be engaged in AMT but it is unclear…

  7. Retention and Advancement in the Retail Industry: A Career Ladder Approach.

    ERIC Educational Resources Information Center

    Prince, Heath J.

    Retailing is the largest industry in the United States, employing roughly 18 percent of the total labor force. However, high turnover resulting from low wages in entry-level positions and the perceptions of retail workers that job security is far from certain and that advancement potential is limited have resulted in low levels of employee…

  8. Identifying patients with advanced chronic conditions for a progressive palliative care approach: a cross-sectional study of prognostic indicators related to end-of-life trajectories

    PubMed Central

    Amblàs-Novellas, J; Murray, S A; Espaulella, J; Martinez-Muñoz, M; Blay, C; Gómez-Batiste, X

    2016-01-01

    Objectives 2 innovative concepts have lately been developed to radically improve the care of patients with advanced chronic conditions (PACC): early identification of palliative care (PC) needs and the 3 end-of-life trajectories in chronic illnesses (acute, intermittent and gradual dwindling). It is not clear (1) what indicators work best for this early identification and (2) if specific clinical indicators exist for each of these trajectories. The objectives of this study are to explore these 2 issues. Setting 3 primary care services, an acute care hospital, an intermediate care centre and 4 nursing homes in a mixed urban–rural district in Barcelona, Spain. Participants 782 patients (61.5% women) with a positive NECPAL CCOMS-ICO test, indicating they might benefit from a PC approach. Outcome measures The characteristics and distribution of the indicators of the NECPAL CCOMS-ICO tool are analysed with respect to the 3 trajectories and have been arranged by domain (functional, nutritional and cognitive status, emotional problems, geriatric syndromes, social vulnerability and others) and according to their static (severity) and dynamic (progression) properties. Results The common indicators associated with early end-of-life identification are functional (44.3%) and nutritional (30.7%) progression, emotional distress (21.9%) and geriatric syndromes (15.7% delirium, 11.2% falls). The rest of the indicators showed differences in the associations per illness trajectories (p<0.05). 48.2% of the total cohort was identified as advanced frailty patients with no advanced disease criteria. Conclusions Dynamic indicators are present in the 3 trajectories and are especially useful to identify PACC for a progressive PC approach purpose. Most of the other indicators are typically associated with a specific trajectory. These findings can help clinicians improve the identification of patients for a palliative approach. PMID:27645556

  9. Aberration measurement from specific photolithographic images: a different approach.

    PubMed

    Nomura, H; Tawarayama, K; Kohno, T

    2000-03-01

    Techniques for measurement of higher-order aberrations of a projection optical system in photolithographic exposure tools have been established. Even-type and odd-type aberrations are independently obtained from printed grating patterns on a wafer by three-beam interference under highly coherent illumination. Even-type aberrations, i.e., spherical aberration and astigmatism, are derived from the best focus positions of vertical, horizontal, and oblique grating patterns by an optical microscope. Odd-type aberrations, i.e., coma and three-foil, are obtained by detection of relative shifts of a fine grating pattern to a large pattern by an overlay inspection tool. Quantitative diagnosis of lens aberrations with a krypton fluoride (KrF) excimer laser scanner is demonstrated.

  10. Measuring efficiency of international crude oil markets: A multifractality approach

    NASA Astrophysics Data System (ADS)

    Niere, H. M.

    2015-01-01

    The three major international crude oil markets are treated as complex systems and their multifractal properties are explored. The study covers daily prices of Brent crude, OPEC reference basket and West Texas Intermediate (WTI) crude from January 2, 2003 to January 2, 2014. A multifractal detrended fluctuation analysis (MFDFA) is employed to extract the generalized Hurst exponents in each of the time series. The generalized Hurst exponent is used to measure the degree of multifractality which in turn is used to quantify the efficiency of the three international crude oil markets. To identify whether the source of multifractality is long-range correlations or broad fat-tail distributions, shuffled data and surrogated data corresponding to each of the time series are generated. Shuffled data are obtained by randomizing the order of the price returns data. This will destroy any long-range correlation of the time series. Surrogated data is produced using the Fourier-Detrended Fluctuation Analysis (F-DFA). This is done by randomizing the phases of the price returns data in Fourier space. This will normalize the distribution of the time series. The study found that for the three crude oil markets, there is a strong dependence of the generalized Hurst exponents with respect to the order of fluctuations. This shows that the daily price time series of the markets under study have signs of multifractality. Using the degree of multifractality as a measure of efficiency, the results show that WTI is the most efficient while OPEC is the least efficient market. This implies that OPEC has the highest likelihood to be manipulated among the three markets. This reflects the fact that Brent and WTI is a very competitive market hence, it has a higher level of complexity compared against OPEC, which has a large monopoly power. Comparing with shuffled data and surrogated data, the findings suggest that for all the three crude oil markets, the multifractality is mainly due to long

  11. Measurement of the Specific Heat Using a Gravity Cancellation Approach

    NASA Technical Reports Server (NTRS)

    Zhong, Fang

    2003-01-01

    The specific heat at constant volume C(sob V) of a simple fluid diverges near its liquid-vapor critical point. However, gravity-induced density stratification due to the divergence of isothermal susceptibility hinders the direct comparison of the experimental data with the predictions of renormalization group theory. In the past, a microgravity environment has been considered essential to eliminate the density stratification. We propose to perform specific heat measurements of He-3 on the ground using a method to cancel the density stratification. A He-3 fluid layer will be heated from below, using the thermal expansion of the fluid to cancel the hydrostatic compression. A 6% density stratification at a reduced temperature of 10(exp -5) can be cancelled to better than 0.1% with a steady 1.7 micro K temperature difference across a 0.05 cm thick fluid layer. A conventional AC calorimetry technique will be used to determine the heat capacity. The minimized bulk density stratification with a relaxation time 6500 sec at a reduced temperature of 10(exp -5) will stay unchanged during 1 Hz AC heating. The smear of the specific heat divergence due to the temperature difference across the cell is about 0.1% at a reduced temperature of 10(exp -6). The combination of using High Resolution Thermometry with a 0.5 n K temperature resolution in the AC technique and the cancellation of the density stratification will enable C(sub V) to be measured down to a reduced temperature of 10(exp -6) with less than a 1% systematic error.

  12. Is uniportal thoracoscopic surgery a feasible approach for advanced stages of non-small cell lung cancer?

    PubMed Central

    Fieira, Eva; Delgado, Maria; Mendez, Lucía; Fernandez, Ricardo; de la Torre, Mercedes

    2014-01-01

    Objectives Conventional video-assisted thoracoscopic (VATS) lobectomy for advanced lung cancer is a feasible and safe surgery in experienced centers. The aim of this study is to assess the feasibility of uniportal VATS approach in the treatment of advanced non-small cell lung cancer (NSCLC) and compare the perioperative outcomes and survival with those in early-stage tumors operated through the uniportal approach. Methods From June 2010 to December 2012, we performed 163 uniportal VATS major pulmonary resections. Only NSCLC cases were included in this study (130 cases). Patients were divided into two groups: (A) early stage and (B) advanced cases (>5 cm, T3 or T4, or tumors requiring neoadjuvant treatment). A descriptive and retrospective study was performed, comparing perioperative outcomes and survival obtained in both groups. A survival analysis was performed with Kaplan-Meier curves and the log-rank test was used to compare survival between patients with early and advanced stages. Results A total of 130 cases were included in the study: 87 (A) vs. 43 (B) patients (conversion rate 1.1 vs. 6.5%, P=0.119). Mean global age was 64.9 years and 73.8% were men. The patient demographic data was similar in both groups. Upper lobectomies (A, 52 vs. B, 21 patients) and anatomic segmentectomies (A, 4 vs. B, 0) were more frequent in group A while pneumonectomy was more frequent in B (A, 1 vs. B, 6 patients). Surgical time was longer (144.9±41.3 vs. 183.2±48.9, P<0.001), and median number of lymph nodes (14 vs. 16, P=0.004) were statistically higher in advanced cases. Median number of nodal stations (5 vs. 5, P=0.165), days of chest tube (2 vs. 2, P=0.098), HOS (3 vs. 3, P=0.072), and rate of complications (17.2% vs. 14%, P=0.075) were similar in both groups. One patient died on the 58th postoperative day. The 30-month survival rate was 90% for the early stage group and 74% for advanced cases Conclusions Uniportal VATS lobectomy for advanced cases of NSCLC is a safe and

  13. An isotopic approach to measuring nitrogen balance in caribou

    USGS Publications Warehouse

    Gustine, D.D.; Barboza, P.S.; Adams, L.G.; Farnell, R.G.; Parker, K.L.

    2011-01-01

    Nutritional restrictions in winter may reduce the availability of protein for reproduction and survival in northern ungulates. We refined a technique that uses recently voided excreta on snow to assess protein status in wild caribou (Rangifer tarandus) in late winter. Our study was the first application of this non-invasive, isotopic approach to assess protein status of wild caribou by determining dietary and endogenous contributions of nitrogen (N) to urinary urea. We used isotopic ratios of N (??15N) in urine and fecal samples to estimate the proportion of urea N derived from body N (p-UN) in pregnant, adult females of the Chisana Herd, a small population that ranged across the Alaska-Yukon border. We took advantage of a predator-exclosure project to examine N status of penned caribou in April 2006. Lichens were the primary forage (>40%) consumed by caribou in the pen and ?? 15N of fiber tracked the major forages in their diets. The ??15N of urinary urea for females in the pen was depleted relative (-1.3 ?? 1.0 parts per thousand [??], x?? ?? SD) to the ??15N of body N (2.7 ?? 0.7??). A similar proportion of animals in the exclosure lost core body mass (excluding estimates of fetal and uterine tissues; 55%) and body protein (estimated by isotope ratios; 54%). This non-invasive technique could be applied at various spatial and temporal scales to assess trends in protein status of free-ranging populations of northern ungulates. Intra- and inter-annual estimates of protein status could help managers monitor effects of foraging conditions on nutritional constraints in ungulates, increase the efficiency and efficacy of management actions, and help prepare stakeholders for potential changes in population trends. ?? 2010 The Wildlife Society.

  14. Advancing the Science of Spatial Neglect Rehabilitation: An Improved Statistical Approach with Mixed Linear Modeling

    PubMed Central

    Goedert, Kelly M.; Boston, Raymond C.; Barrett, A. M.

    2013-01-01

    Valid research on neglect rehabilitation demands a statistical approach commensurate with the characteristics of neglect rehabilitation data: neglect arises from impairment in distinct brain networks leading to large between-subject variability in baseline symptoms and recovery trajectories. Studies enrolling medically ill, disabled patients, may suffer from missing, unbalanced data, and small sample sizes. Finally, assessment of rehabilitation requires a description of continuous recovery trajectories. Unfortunately, the statistical method currently employed in most studies of neglect treatment [repeated measures analysis of variance (ANOVA), rANOVA] does not well-address these issues. Here we review an alternative, mixed linear modeling (MLM), that is more appropriate for assessing change over time. MLM better accounts for between-subject heterogeneity in baseline neglect severity and in recovery trajectory. MLM does not require complete or balanced data, nor does it make strict assumptions regarding the data structure. Furthermore, because MLM better models between-subject heterogeneity it often results in increased power to observe treatment effects with smaller samples. After reviewing current practices in the field, and the assumptions of rANOVA, we provide an introduction to MLM. We review its assumptions, uses, advantages, and disadvantages. Using real and simulated data, we illustrate how MLM may improve the ability to detect effects of treatment over ANOVA, particularly with the small samples typical of neglect research. Furthermore, our simulation analyses result in recommendations for the design of future rehabilitation studies. Because between-subject heterogeneity is one important reason why studies of neglect treatments often yield conflicting results, employing statistical procedures that model this heterogeneity more accurately will increase the efficiency of our efforts to find treatments to improve the lives of individuals with neglect. PMID

  15. Advances in Remote Sensing Approaches for Hazard Mitigation and Natural Resource Protection in Pacific Latin America: A Workshop for Advanced Graduate Students, Post- Doctoral Researchers, and Junior Faculty

    NASA Astrophysics Data System (ADS)

    Gierke, J. S.; Rose, W. I.; Waite, G. P.; Palma, J. L.; Gross, E. L.

    2008-12-01

    Though much of the developing world has the potential to gain significantly from remote sensing techniques in terms of public health and safety, they often lack resources for advancing the development and practice of remote sensing. All countries share a mutual interest in furthering remote sensing capabilities for natural hazard mitigation and resource development. With National Science Foundation support from the Partnerships in International Research and Education program, we are developing a new educational system of applied research and engineering for advancing collaborative linkages among agencies and institutions in Pacific Latin American countries (to date: Guatemala, El Salvador, Nicaragua, Costa Rica, Panama, and Ecuador) in the development of remote sensing tools for hazard mitigation and water resources management. The project aims to prepare students for careers in science and engineering through their efforts to solve suites of problems needing creative solutions: collaboration with foreign agencies; living abroad immersed in different cultures; and adapting their academic training to contend with potentially difficult field conditions and limited resources. The ultimate goal of integrating research with education is to encourage cross-disciplinary, creative, and critical thinking in problem solving and foster the ability to deal with uncertainty in analyzing problems and designing appropriate solutions. In addition to traditional approaches for graduate and undergraduate research, we have built new educational systems of applied research and engineering: (1) the Peace Corp/Master's International program in Natural Hazards which features a 2-year field assignment during service in the U.S. Peace Corps, (2) the Michigan Tech Enterprise program for undergraduates, which gives teams of students from different disciplines the opportunity to work for three years in a business-like setting to solve real-world problems, and (3) a unique university exchange

  16. A new approach to mass spectrometer measurements of thermospheric density

    NASA Technical Reports Server (NTRS)

    Melfi, L. T., Jr.; Brock, F. J.; Brown, C. A., Jr.

    1974-01-01

    The gas sampling problem in satellite and high velocity probes was investigated by applying the theory of a drifting Maxwellian gas. A lens system using a free stream ion source was developed and experimentally evaluated over the pressure range of 0.00001 to 0.01 N/m sq (approx. 10 to the minus 7th power to 0.0001 torr). The source has high beam transparency, which minimizes gas-surface collisions within, or near, the ionization volume. It is shown that for high ion energy (60 eV), the extracted ion beam has an on-axis energy spread of less than 4 eV, and that 90 percent of the ions are within 2.5 deg of the beam axis. It is concluded that the molecular beam mass spectrometer concept, developed for gas density measurements in the upper atmosphere, substantially reduces gas-surface scattering and gas-surface reactions in the sample, and preserves the integrity of the gas sample during the analysis process. Studies show that both the Scout and Delta launch vehicles have adequate volume, control, velocity, and data acquisition capability necessary to obtain thermospheric number density in real time.

  17. Measurement of airborne {sup 218}Po - A Bayesian approach

    SciTech Connect

    Groer, P.G.; Lo, Y.

    1996-12-01

    The standard mathematical treatment of the buildup and decay of airborne radionuclides on a filter paper uses the solutions of the so-called bateman equations adapted to the sampling process. The equations can be interpreted as differential equations for the expectation of an underlying stochastic process, which describes the random fluctuations in the accumulation and decay of the sampled radioactive atoms. The process for the buildup and decay of airborne {sup 218}Po can be characterized as an {open_quotes}immigration-death process{close_quotes} in the widely adopted, biologically based jargon. The probability distribution for the number of {sup 218}Po atoms, accumulated after sampling time t, is Poisson. We show that the distribution of the number of counts, registered by a detector with efficiency {epsilon} during a counting period T after the end of sampling, it also Poisson, with mean dependent on {epsilon},t,T, the flowrate and N{sub o}, the number of airborne {sup 218}Po atoms per unit volume. This Poisson distribution was used to construct the likelihood given the observed number of counts. After inversion with Bayes` Theorem we obtained the posterior density for N{sub o}. This density characterizes the remaining uncertainty about the measured under of {sup 218}Po atoms per unit volume of air. 6 refs., 3 figs., 1 tab.

  18. Technologies for Inclusive Education: Beyond Traditional Integration Approaches. Advances in Educational Technologies and Instructional Design

    ERIC Educational Resources Information Center

    Barres, David Griol; Carrion, Zoraida Callejas; Lopez-Cozar Delgado, Ramon

    2013-01-01

    By providing students with the opportunities to receive a high quality education regardless of their social or cultural background, inclusive education is a new area that goes beyond traditional integration approaches. These approaches hope to provide the educative system with the ability to adapt to the diversity of its students. Technologies for…

  19. A Scoping Review of Scoping Reviews: Advancing the Approach and Enhancing the Consistency

    ERIC Educational Resources Information Center

    Pham, Mai T.; Rajic, Andrijana; Greig, Judy D.; Sargeant, Jan M.; Papadopoulos, Andrew; McEwen, Scott A.

    2014-01-01

    Background: The scoping review has become an increasingly popular approach for synthesizing research evidence. It is a relatively new approach for which a universal study definition or definitive procedure has not been established. The purpose of this scoping review was to provide an overview of scoping reviews in the literature. Methods: A…

  20. Hosted Services for Advanced V and V Technologies: An Approach to Achieving Adoption without the Woes of Usage

    NASA Technical Reports Server (NTRS)

    Koga, Dennis (Technical Monitor); Penix, John; Markosian, Lawrence Z.; OMalley, Owen; Brew, William A.

    2003-01-01

    Attempts to achieve widespread use of software verification tools have been notably unsuccessful. Even 'straightforward', classic, and potentially effective verification tools such as lint-like tools face limits on their acceptance. These limits are imposed by the expertise required applying the tools and interpreting the results, the high false positive rate of many verification tools, and the need to integrate the tools into development environments. The barriers are even greater for more complex advanced technologies such as model checking. Web-hosted services for advanced verification technologies may mitigate these problems by centralizing tool expertise. The possible benefits of this approach include eliminating the need for software developer expertise in tool application and results filtering, and improving integration with other development tools.

  1. Development of Computational Approaches for Simulation and Advanced Controls for Hybrid Combustion-Gasification Chemical Looping

    SciTech Connect

    Joshi, Abhinaya; Lou, Xinsheng; Neuschaefer, Carl; Chaudry, Majid; Quinn, Joseph

    2012-07-31

    This document provides the results of the project through September 2009. The Phase I project has recently been extended from September 2009 to March 2011. The project extension will begin work on Chemical Looping (CL) Prototype modeling and advanced control design exploration in preparation for a scale-up phase. The results to date include: successful development of dual loop chemical looping process models and dynamic simulation software tools, development and test of several advanced control concepts and applications for Chemical Looping transport control and investigation of several sensor concepts and establishment of two feasible sensor candidates recommended for further prototype development and controls integration. There are three sections in this summary and conclusions. Section 1 presents the project scope and objectives. Section 2 highlights the detailed accomplishments by project task area. Section 3 provides conclusions to date and recommendations for future work.

  2. An integrated approach: advances in the use of Clostridium for biofuel.

    PubMed

    Kök, M Samil

    2015-01-01

    Almost 90% of our energy comes from fossil fuels, which are both limited and polluting, hence the need to find alternative sources. Biofuels can provide a sustainable and renewable source of energy for the future. Recent significant advances in genetic engineering and fermentation technology have made microbial bio-based production of chemicals from renewable resources more viable. Clostridium species are considered as promising micro-organisms for the production of a wide range of chemicals for industrial use. However, a number of scientific challenges still need to be overcome to facilitate an economically viable production system. These include the use of cheap non-food-based substrates, a better understanding of the metabolic processes involved, improvement of strains through genetic engineering and innovation in process technology. This paper reviews recent developments in these areas, advancing the use of Clostridium within an industrial context especially for the production of biofuels.

  3. An advanced Thermal-FSI approach to flow heating/cooling

    NASA Astrophysics Data System (ADS)

    Badur, J.; Ziółkowski, P.; Zakrzewski, W.; Sławiński, D.; Kornet, S.; Kowalczyk, T.; Hernet, J.; Piotrowski, R.; Felincjancik, J.; Ziółkowski, P. J.

    2014-08-01

    Actually, two-way thermal-energy exchange between working fluid and solid material of a casing is a leading problem for modern - semi automatic - design techniques. Many questions should be solved, especially, the turbulent mode of thermal energy transport both in fluid and solid, should be re-examined and reformulated from the primary principles. In the present paper, a group of researchers from Energy Conversion Department of IMP PAN at Gdańsk, tries to summarise a last three-years efforts towards to mathematical modelling of advanced models of thermal energy transport. This extremely difficult problem in "thermal-FSI" ("Fluid Solid Interaction") means that the both for solid and fluid mathematical model of a surface layer should be self-equilibrated and self-concise. Taking these requirements into account, an advanced Reynolds-Stanton analogy has been discussed and implemented. Some numerical examples concerning of the benchmarks experiments and industrial applications have also been developed and presented.

  4. An integrated approach: advances in the use of Clostridium for biofuel.

    PubMed

    Kök, M Samil

    2015-01-01

    Almost 90% of our energy comes from fossil fuels, which are both limited and polluting, hence the need to find alternative sources. Biofuels can provide a sustainable and renewable source of energy for the future. Recent significant advances in genetic engineering and fermentation technology have made microbial bio-based production of chemicals from renewable resources more viable. Clostridium species are considered as promising micro-organisms for the production of a wide range of chemicals for industrial use. However, a number of scientific challenges still need to be overcome to facilitate an economically viable production system. These include the use of cheap non-food-based substrates, a better understanding of the metabolic processes involved, improvement of strains through genetic engineering and innovation in process technology. This paper reviews recent developments in these areas, advancing the use of Clostridium within an industrial context especially for the production of biofuels. PMID:27160660

  5. Pressure driven spinning: A multifaceted approach for preparing nanoscaled functionalized fibers, scaffolds, and membranes with advanced materials.

    PubMed

    Jayasinghe, Suwan N; Suter, Nicolai

    2010-03-02

    Electrospinning, a flexible jet-based fiber, scaffold, and membrane fabrication approach, has been elucidated as having significance to the heath sciences. Its capabilities have been most impressive as it possesses the ability to spin composite fibers ranging from the nanometer to the micrometer scale. Nonetheless, electrospinning has limitations and hazards, negating its wider exploration, for example, the inability to handle highly conducting suspensions, to its hazardous high voltage. Hence, to date electrospinning has undergone an exhaustive research regime to a point of cliché. Thus, in the work reported herein we unveil a competing technique to electrospinning, which has overcome the above limitations and hazards yet comparable in capabilities. The fiber preparation approach unearthed herein is referred to as "pressure driven spinning (PDS)." The driving mechanism exploited in this fiber spinning process is the pressurized by-pass flow. This mechanism allows the drawing of either micro- or nanosized fibers while processing polymeric suspensions containing a wide range of advanced materials spanning structural, functional, and biological entities. Similar to electrospinning if the collection time of these continuous formed fibers is varied, composite scaffolds and membranes are generated. In keeping with our interests, multicompositional structural entities such as these could have several applications in biology and medicine, for example, ranging from the development of three-dimensional cultures (including disease models) to the development of synthetic tissues and organ structures to advanced approaches for controlled and targeted therapeutics.

  6. Perceived vs. measured effects of advanced cockpit systems on pilot workload and error: are pilots' beliefs misaligned with reality?

    PubMed

    Casner, Stephen M

    2009-05-01

    Four types of advanced cockpit systems were tested in an in-flight experiment for their effect on pilot workload and error. Twelve experienced pilots flew conventional cockpit and advanced cockpit versions of the same make and model airplane. In both airplanes, the experimenter dictated selected combinations of cockpit systems for each pilot to use while soliciting subjective workload measures and recording any errors that pilots made. The results indicate that the use of a GPS navigation computer helped reduce workload and errors during some phases of flight but raised them in others. Autopilots helped reduce some aspects of workload in the advanced cockpit airplane but did not appear to reduce workload in the conventional cockpit. Electronic flight and navigation instruments appeared to have no effect on workload or error. Despite this modest showing for advanced cockpit systems, pilots stated an overwhelming preference for using them during all phases of flight.

  7. Requirements and Technology Advances for Global Wind Measurement with a Coherent Lidar: A Shrinking Gap

    NASA Technical Reports Server (NTRS)

    Kavaya, Michael J.; Kavaya, Michael J.; Yu, Jirong; Koch, Grady J.; Amzajerdian, Farzin; Singh, Upendra N.; Emmitt, G. David

    2007-01-01

    Early concepts to globally measure vertical profiles of vector horizontal wind from space planned on an orbit height of 525 km, a single pulsed coherent Doppler lidar system to cover the full troposphere, and a continuously rotating telescope/scanner that mandated a vertical line of sight wind profile from each laser shot. Under these conditions system studies found that laser pulse energies of approximately 20 J at 10 Hz pulse repetition rate with a rotating telescope diameter of approximately 1.5 m was required. Further requirements to use solid state laser technology and an eyesafe wavelength led to the relatively new 2-micron solid state laser. With demonstrated pulse energies near 20 mJ at 5 Hz, and no demonstration of a rotating telescope maintaining diffraction limited performance in space, the technology gap between requirements and demonstration was formidable. Fortunately the involved scientists and engineers set out to reduce the gap, and through a combination of clever ideas and technology advances over the last 15 years, they have succeeded. This paper will detail the gap reducing factors and will present the current status.

  8. Advances in Surface Plasmon Resonance Imaging enable quantitative measurement of laterally heterogeneous coatings of nanoscale thickness

    NASA Astrophysics Data System (ADS)

    Raegen, Adam; Reiter, Kyle; Clarke, Anthony; Lipkowski, Jacek; Dutcher, John

    2013-03-01

    The Surface Plasmon Resonance (SPR) phenomenon is routinely exploited to qualitatively probe changes to the optical properties of nanoscale coatings on thin metallic surfaces, for use in probes and sensors. Unfortunately, extracting truly quantitative information is usually limited to a select few cases - uniform absorption/desorption of small biomolecules and films, in which a continuous ``slab'' model is a good approximation. We present advancements in the SPR technique that expand the number of cases for which the technique can provide meaningful results. Use of a custom, angle-scanning SPR imaging system, together with a refined data analysis method, allow for quantitative kinetic measurements of laterally heterogeneous systems. We first demonstrate the directionally heterogeneous nature of the SPR phenomenon using a directionally ordered sample, then show how this allows for the calculation of the average coverage of a heterogeneous sample. Finally, the degradation of cellulose microfibrils and bundles of microfibrils due to the action of cellulolytic enzymes will be presented as an excellent example of the capabilities of the SPR imaging system.

  9. Design and Laboratory Evaluation of Future Elongation and Diameter Measurements at the Advanced Test Reactor

    SciTech Connect

    K. L. Davis; D. L. Knudson; J. L. Rempe; J. C. Crepeau; S. Solstad

    2015-07-01

    New materials are being considered for fuel, cladding, and structures in next generation and existing nuclear reactors. Such materials can undergo significant dimensional and physical changes during high temperature irradiations. In order to accurately predict these changes, real-time data must be obtained under prototypic irradiation conditions for model development and validation. To provide such data, researchers at the Idaho National Laboratory (INL) High Temperature Test Laboratory (HTTL) are developing several instrumented test rigs to obtain data real-time from specimens irradiated in well-controlled pressurized water reactor (PWR) coolant conditions in the Advanced Test Reactor (ATR). This paper reports the status of INL efforts to develop and evaluate prototype test rigs that rely on Linear Variable Differential Transformers (LVDTs) in laboratory settings. Although similar LVDT-based test rigs have been deployed in lower flux Materials Testing Reactors (MTRs), this effort is unique because it relies on robust LVDTs that can withstand higher temperatures and higher fluxes than often found in other MTR irradiations. Specifically, the test rigs are designed for detecting changes in length and diameter of specimens irradiated in ATR PWR loops. Once implemented, these test rigs will provide ATR users with unique capabilities that are sorely needed to obtain measurements such as elongation caused by thermal expansion and/or creep loading and diameter changes associated with fuel and cladding swelling, pellet-clad interaction, and crud buildup.

  10. Advanced Computational Approaches for Characterizing Stochastic Cellular Responses to Low Dose, Low Dose Rate Exposures

    SciTech Connect

    Scott, Bobby, R., Ph.D.

    2003-06-27

    OAK - B135 This project final report summarizes modeling research conducted in the U.S. Department of Energy (DOE), Low Dose Radiation Research Program at the Lovelace Respiratory Research Institute from October 1998 through June 2003. The modeling research described involves critically evaluating the validity of the linear nonthreshold (LNT) risk model as it relates to stochastic effects induced in cells by low doses of ionizing radiation and genotoxic chemicals. The LNT model plays a central role in low-dose risk assessment for humans. With the LNT model, any radiation (or genotoxic chemical) exposure is assumed to increase one¡¯s risk of cancer. Based on the LNT model, others have predicted tens of thousands of cancer deaths related to environmental exposure to radioactive material from nuclear accidents (e.g., Chernobyl) and fallout from nuclear weapons testing. Our research has focused on developing biologically based models that explain the shape of dose-response curves for low-dose radiation and genotoxic chemical-induced stochastic effects in cells. Understanding the shape of the dose-response curve for radiation and genotoxic chemical-induced stochastic effects in cells helps to better understand the shape of the dose-response curve for cancer induction in humans. We have used a modeling approach that facilitated model revisions over time, allowing for timely incorporation of new knowledge gained related to the biological basis for low-dose-induced stochastic effects in cells. Both deleterious (e.g., genomic instability, mutations, and neoplastic transformation) and protective (e.g., DNA repair and apoptosis) effects have been included in our modeling. Our most advanced model, NEOTRANS2, involves differing levels of genomic instability. Persistent genomic instability is presumed to be associated with nonspecific, nonlethal mutations and to increase both the risk for neoplastic transformation and for cancer occurrence. Our research results, based on

  11. Advances in Mineral Dust Source Composition Measurement with Imaging Spectroscopy at the Salton Sea, CA

    NASA Astrophysics Data System (ADS)

    Green, R. O.; Realmuto, V. J.; Thompson, D. R.; Mahowald, N. M.; Pérez García-Pando, C.; Miller, R. L.; Clark, R. N.; Swayze, G. A.; Okin, G. S.

    2015-12-01

    Mineral dust emitted from the Earth's surface is a principal contributor to direct radiative forcing over the arid regions, where shifts in climate have a significant impact on agriculture, precipitation, and desert encroachment around the globe. Dust particles contribute to both positive and negative forcing, depending on the composition of the particles. Particle composition is a function of the surface mineralogy of dust source regions, but poor knowledge of surface mineralogy on regional to global scales limits the skill of Earth System models to predict shifts in regional climate around the globe. Earth System models include the source, emission, transport and deposition phases of the dust cycle. In addition to direct radiative forcing contributions, mineral dust impacts include indirect radiative forcing, modification of the albedo and melting rates of snow and ice, kinetics of tropospheric photochemistry, formation and deposition of acidic aerosols, supply of nutrients to aquatic and terrestrial ecosystems, and impact on human health and safety. We demonstrate the ability to map mineral dust source composition in the Salton Sea dust source region with imaging spectroscopy measurements acquired as part of the NASA HyspIRI preparatory airborne campaign. These new spectroscopically derived compositional measurements provide a six orders of magnitude improvement over current atlases for this dust source region and provide a pathfinder example for a remote measurement approach to address this critical dust composition gap for global Earth System models.

  12. Advanced imaging as a novel approach to the characterization of membranes for microfiltration applications

    NASA Astrophysics Data System (ADS)

    Marroquin, Milagro

    : dextran) within wet, asymmetric polyethersulfone microfiltration membranes. Information from filtration flux profiles and cross-sectional CLSM images of the membranes that processed single-component solutions and mixtures agreed with each other. Concentration profiles versus depth for each individual component present in the feed solution were developed from the analysis of the CLSM images at different levels of fouling for single-component solutions and mixtures. CLSM provided visual information that helped elucidate the role of each component on membrane fouling and provided a better understanding of how component interactions impact the fouling profiles. Finally, Chapter 4 extends the application of my cross-sectional CLSM imaging protocol to study the fouling of asymmetric polyethersulfone membranes during the microfiltration of protein, polyphenol, and polysaccharide mixtures to better understand the solute-solute and solute-membrane interactions leading to fouling in beverage clarification processes. Again, cross-sectional CLSM imaging provided information on the location and extent of fouling throughout the entire thickness of the PES membrane. Quantitative analysis of the cross-sectional CLSM images provided a measurement of the masses of foulants deposited throughout the membrane. Moreover, flux decline data collected for different mixtures of casein, tannic acid and beta-cyclodextrin were analyzed with standard fouling models to determine the fouling mechanisms at play when processing different combinations of foulants. Results from model analysis of flux data were compared with the quantitative visual analysis of the correspondent CLSM images. This approach, which couples visual and performance measurements, is expected to provide a better understanding of the causes of fouling that, in turn, is expected to aid in the design of new membranes with tailored structure or surface chemistry that prevents the deposition of the foulants in "prone to foul" regions

  13. Characterization of geolocation accuracy of Suomi NPP Advanced Technology Microwave Sounder measurements

    NASA Astrophysics Data System (ADS)

    Han, Yang; Weng, Fuzhong; Zou, Xiaolei; Yang, Hu; Scott, Deron

    2016-05-01

    The Advanced Technology Microwave Sounder (ATMS) onboard Suomi National Polar-orbiting Partnership satellite has 22 channels at frequencies ranging from 23 to 183 GHz for probing the atmospheric temperature and moisture under all weather conditions. As part of the ATMS calibration and validation activities, the geolocation accuracy of ATMS data must be well characterized and documented. In this study, the coastline crossing method (CCM) and the land-sea fraction method (LFM) are utilized to characterize and quantify the ATMS geolocation accuracy. The CCM is based on the inflection points of the ATMS window channel measurements across the coastlines, whereas the LFM collocates the ATMS window channel data with high-resolution land-sea mask data sets. Since the ATMS measurements provide five pairs of latitude and longitude data for K, Ka, V, W, and G bands, respectively, the window channels 1, 2, 3, 16, and 17 from each of these five bands are chosen for assessing the overall geolocation accuracy. ATMS geolocation errors estimated from both methods are generally consistent from 40 cases in June 2014. The ATMS along-track (cross-track) errors at nadir are within ±4.2 km (±1.2 km) for K/Ka, ±2.6 km (±2.7 km) for V bands, and ±1.2 km (±0.6 km) at W and G bands, respectively. At the W band, the geolocation errors derived from both algorithms are probably less reliable due to a reduced contrast of brightness temperatures in coastal areas. These estimated ATMS along-track and cross-track geolocation errors are well within the uncertainty requirements for all bands.

  14. Accumulation of advanced glycation end products, measured as skin autofluorescence, in renal disease.

    PubMed

    Hartog, Jasper W L; de Vries, Aiko P J; Lutgers, Helen L; Meerwaldt, Robbert; Huisman, Roel M; van Son, Willem J; de Jong, Paul E; Smit, Andries J

    2005-06-01

    Advanced glycation end products (AGEs) accumulate during renal failure and dialysis. Kidney transplantation is thought to reverse this accumulation by restoring renal function. Using a noninvasive and validated autofluorescence reader, we evaluated AGE levels in 285 transplant recipients (mean age, 52 years; range, 41 to 60 years), 32 dialysis patients (mean age, 56 years; range, 43 to 65 years), and 231 normal control subjects (mean age, 51 years; range, 40 to 65 years). Measurements in transplant recipients were performed for a mean of 73 months (range, 32 to 143 months) after transplantation. Dialysis patients were on dialysis therapy for a mean of 42 months (range, 17 to 107 months). Fluorescence was significantly increased in dialysis patients compared with normal control subjects (2.8 vs. 2.0 arbitrary units [a.u.], P < .0001). Although fluorescence levels were significantly decreased in transplant recipients compared with dialysis patients (2.5 vs. 2.8 a.u., P < .0001), fluorescence in transplant recipients was higher than in controls (2.5 vs. 2.0 a.u., P < .0001). In transplant recipients, fluorescence correlated positively with the duration of dialysis prior to transplantation (R = 0.21, P < .0001), and negatively with creatinine clearance (R = -0.34, P < .0001). No correlation was found between time after transplantation and fluorescence in transplant recipients (R = -0.10, P = .10). Fluorescence in dialysis patients was positively correlated with duration of dialysis (R = 0.36, P = .042). Our results, like those of others, suggest that kidney transplantation does not fully correct increased AGE levels found in dialysis patients. The increased AGE levels in kidney transplant recipients cannot be explained by the differences in renal function alone. The availability of a simple, noninvasive method (AGE-Reader) to measure AGE accumulation may be used to monitor AGE accumulation in a clinical setting as well as in a study setting.

  15. Advanced glycation end products measured by skin autofluorescence in a population with central obesity.

    PubMed

    den Engelsen, Corine; van den Donk, Maureen; Gorter, Kees J; Salomé, Philippe L; Rutten, Guy E

    2012-01-01

    Accumulation of advanced glycation end products (AGEs) is enhanced by chronic hyperglycemia and oxidative stress and this process may contribute to the pathogenesis of vascular disease. Skin autofluorescence (AF), a measure of accumulation of AGEs in skin collagen, is associated with vascular disease in patients with diabetes.   Because central obesity enhances oxidative stress people with central obesity might already have increased accumulation of AGEs before diabetes or cardiovascular disease become manifest. To test this hypothesis, we compared the distribution of skin AF and its association with clinical and biochemical parameters in individuals with and without central obesity. Skin AF was measured by a validated AGE Reader in 816 persons with and 431 persons without central obesity, aged 20-70 y. Mean skin AF increased with age and smoking and was higher in centrally obese individuals compared with non-obese individuals (p = 0.001, after adjustment for age and smoking p = 0.13). Mean skin AF in the subgroups without central obesity and without other risk factors (n = 106), central obesity without other risk factors (n = 74) and central obesity with other risk factors (n = 742) was 1.63 ± 0.37, 1.74 ± 0.44 and 1.87 ± 0.43 AU, respectively (p for trend < 0.001, after adjustment for age and smoking p for trend = 0.12). In the group with central obesity age, current smoking, alcohol consumption, waist circumference, creatinine clearance and hs-CRP were independently associated with skin AF (R(2) = 29.4%). Waist circumference hardly contributed to the explained variance. The relationship between waist circumference and skin AF is not as obvious as we hypothesized.

  16. Accumulation of advanced glycation end products, measured as skin autofluorescence, in renal disease.

    PubMed

    Hartog, Jasper W L; de Vries, Aiko P J; Lutgers, Helen L; Meerwaldt, Robbert; Huisman, Roel M; van Son, Willem J; de Jong, Paul E; Smit, Andries J

    2005-06-01

    Advanced glycation end products (AGEs) accumulate during renal failure and dialysis. Kidney transplantation is thought to reverse this accumulation by restoring renal function. Using a noninvasive and validated autofluorescence reader, we evaluated AGE levels in 285 transplant recipients (mean age, 52 years; range, 41 to 60 years), 32 dialysis patients (mean age, 56 years; range, 43 to 65 years), and 231 normal control subjects (mean age, 51 years; range, 40 to 65 years). Measurements in transplant recipients were performed for a mean of 73 months (range, 32 to 143 months) after transplantation. Dialysis patients were on dialysis therapy for a mean of 42 months (range, 17 to 107 months). Fluorescence was significantly increased in dialysis patients compared with normal control subjects (2.8 vs. 2.0 arbitrary units [a.u.], P < .0001). Although fluorescence levels were significantly decreased in transplant recipients compared with dialysis patients (2.5 vs. 2.8 a.u., P < .0001), fluorescence in transplant recipients was higher than in controls (2.5 vs. 2.0 a.u., P < .0001). In transplant recipients, fluorescence correlated positively with the duration of dialysis prior to transplantation (R = 0.21, P < .0001), and negatively with creatinine clearance (R = -0.34, P < .0001). No correlation was found between time after transplantation and fluorescence in transplant recipients (R = -0.10, P = .10). Fluorescence in dialysis patients was positively correlated with duration of dialysis (R = 0.36, P = .042). Our results, like those of others, suggest that kidney transplantation does not fully correct increased AGE levels found in dialysis patients. The increased AGE levels in kidney transplant recipients cannot be explained by the differences in renal function alone. The availability of a simple, noninvasive method (AGE-Reader) to measure AGE accumulation may be used to monitor AGE accumulation in a clinical setting as well as in a study setting. PMID:16037252

  17. Advanced glycation end products measured by skin autofluorescence in a population with central obesity.

    PubMed

    den Engelsen, Corine; van den Donk, Maureen; Gorter, Kees J; Salomé, Philippe L; Rutten, Guy E

    2012-01-01

    Accumulation of advanced glycation end products (AGEs) is enhanced by chronic hyperglycemia and oxidative stress and this process may contribute to the pathogenesis of vascular disease. Skin autofluorescence (AF), a measure of accumulation of AGEs in skin collagen, is associated with vascular disease in patients with diabetes.   Because central obesity enhances oxidative stress people with central obesity might already have increased accumulation of AGEs before diabetes or cardiovascular disease become manifest. To test this hypothesis, we compared the distribution of skin AF and its association with clinical and biochemical parameters in individuals with and without central obesity. Skin AF was measured by a validated AGE Reader in 816 persons with and 431 persons without central obesity, aged 20-70 y. Mean skin AF increased with age and smoking and was higher in centrally obese individuals compared with non-obese individuals (p = 0.001, after adjustment for age and smoking p = 0.13). Mean skin AF in the subgroups without central obesity and without other risk factors (n = 106), central obesity without other risk factors (n = 74) and central obesity with other risk factors (n = 742) was 1.63 ± 0.37, 1.74 ± 0.44 and 1.87 ± 0.43 AU, respectively (p for trend < 0.001, after adjustment for age and smoking p for trend = 0.12). In the group with central obesity age, current smoking, alcohol consumption, waist circumference, creatinine clearance and hs-CRP were independently associated with skin AF (R(2) = 29.4%). Waist circumference hardly contributed to the explained variance. The relationship between waist circumference and skin AF is not as obvious as we hypothesized. PMID:22870350

  18. An approach to knowledge structuring for advanced phases of the Technical and Management Information System (TMIS)

    NASA Technical Reports Server (NTRS)

    Goranson, H. T.

    1986-01-01

    The Technical and Management Information System (TMIS) must employ on enlightened approach to its object structure, but basic issues in conceptual structuring remain to be resolved. Sirius outlines the necessary agenda and reports on progress toward solutions.

  19. Some recent advances in the bottom-up holographic approach to QCD

    SciTech Connect

    Afonin, S. S.

    2014-07-23

    We give a brief report on our recent results in the bottom-up holographic approach to QCD. The holographic description of the heavy vector quarkonia and generalization of the Soft Wall model are discussed.

  20. Using and Developing Measurement Instruments in Science Education: A Rasch Modeling Approach. Science & Engineering Education Sources

    ERIC Educational Resources Information Center

    Liu, Xiufeng

    2010-01-01

    This book meets a demand in the science education community for a comprehensive and introductory measurement book in science education. It describes measurement instruments reported in refereed science education research journals, and introduces the Rasch modeling approach to developing measurement instruments in common science assessment domains,…

  1. Advances in Proteomics Data Analysis and Display Using an Accurate Mass and Time Tag Approach

    SciTech Connect

    Zimmer, Jennifer S.; Monroe, Matthew E.; Qian, Weijun; Smith, Richard D.

    2006-01-20

    Proteomics, and the larger field of systems biology, have recently demonstrated utility in both the understanding of cellular processes on the molecular level and the identification of potential biomarkers of various disease states. The large amount of data generated by utilizing high mass accuracy mass spectrometry for high-throughput proteomics analyses presents a challenge in data processing, analysis and display. This review focuses on recent advances in nanoLC-FTICR-MS-based proteomics analysis and the accompanying data processing tools that have been developed in order to interpret and display the large volumes of data produced.

  2. A New Approach of Measuring Hospital Performance for Low- and Middle-income Countries

    PubMed Central

    Sapkota, Vishnu Prasad; Supakankunti, Siripen

    2015-01-01

    Efficiency of the hospitals affects the price of health services. Health care payments have equity implications. Evidence on hospital performance can support to design the policy; however, the recent literature on hospital efficiency produced conflicting results. Consequently, policy decisions are uncertain. Even the most of evidence were produced by using data from high income countries. Conflicting results were produced particularly due to differences in methods of measuring performance. Recently a management approach has been developed to measure the hospital performance. This approach to measure the hospital performance is very useful from policy perspective to improve health system from cost-effective way in low and middle income countries. Measuring hospital performance through management approach has some basic characteristics such as scoring management practices through double blind survey, measuring hospital outputs using various indicators, estimating the relationship between management practices and outputs of the hospitals. This approach has been successfully applied to developed countries; however, some revisions are required without violating the fundamental principle of this approach to replicate in low- and middle-income countries. The process has been clearly defined and applied to Nepal. As the results of this, the approach produced expected results. The paper contributes to improve the approach to measure hospital performance. PMID:26617448

  3. A New Approach of Measuring Hospital Performance for Low- and Middle-income Countries.

    PubMed

    Adhikari, Shiva Raj; Sapkota, Vishnu Prasad; Supakankunti, Siripen

    2015-11-01

    Efficiency of the hospitals affects the price of health services. Health care payments have equity implications. Evidence on hospital performance can support to design the policy; however, the recent literature on hospital efficiency produced conflicting results. Consequently, policy decisions are uncertain. Even the most of evidence were produced by using data from high income countries. Conflicting results were produced particularly due to differences in methods of measuring performance. Recently a management approach has been developed to measure the hospital performance. This approach to measure the hospital performance is very useful from policy perspective to improve health system from cost-effective way in low and middle income countries. Measuring hospital performance through management approach has some basic characteristics such as scoring management practices through double blind survey, measuring hospital outputs using various indicators, estimating the relationship between management practices and outputs of the hospitals. This approach has been successfully applied to developed countries; however, some revisions are required without violating the fundamental principle of this approach to replicate in low- and middle-income countries. The process has been clearly defined and applied to Nepal. As the results of this, the approach produced expected results. The paper contributes to improve the approach to measure hospital performance. PMID:26617448

  4. A New Approach of Measuring Hospital Performance for Low- and Middle-income Countries.

    PubMed

    Adhikari, Shiva Raj; Sapkota, Vishnu Prasad; Supakankunti, Siripen

    2015-11-01

    Efficiency of the hospitals affects the price of health services. Health care payments have equity implications. Evidence on hospital performance can support to design the policy; however, the recent literature on hospital efficiency produced conflicting results. Consequently, policy decisions are uncertain. Even the most of evidence were produced by using data from high income countries. Conflicting results were produced particularly due to differences in methods of measuring performance. Recently a management approach has been developed to measure the hospital performance. This approach to measure the hospital performance is very useful from policy perspective to improve health system from cost-effective way in low and middle income countries. Measuring hospital performance through management approach has some basic characteristics such as scoring management practices through double blind survey, measuring hospital outputs using various indicators, estimating the relationship between management practices and outputs of the hospitals. This approach has been successfully applied to developed countries; however, some revisions are required without violating the fundamental principle of this approach to replicate in low- and middle-income countries. The process has been clearly defined and applied to Nepal. As the results of this, the approach produced expected results. The paper contributes to improve the approach to measure hospital performance.

  5. Treatment approaches in patients with advanced non-small cell lung cancer and poor performance status.

    PubMed

    Govindan, Ramaswamy; Garfield, David H

    2004-12-01

    It is estimated that 30% to 40% of patients with advanced non-small cell lung cancer (NSCLC) have a poor performance status (PS)-defined as a score of 2 or higher on the Eastern Cooperative Oncology Group scale-because of their disease burden, comorbidities, or both. Survival is shorter in these patients than in those with a better PS, and they do not tolerate chemotherapy as well. There is now evidence that PS2 patients with advanced NSCLC can benefit from single-agent chemotherapy with drugs such as vinorelbine, gemcitabine, paclitaxel, pemetrexed, and docetaxel and that combination chemotherapy may have additional advantages. The optimal treatment for PS2 patients with NSCLC, however, has yet to be determined. The case histories in this article demonstrate that PS2 patients are a heterogeneous group and that selecting the chemotherapy for each patient must take into consideration comorbidities and disease-related symptoms, as well as the potential toxicity of treatment. Large prospective clinical trials are needed to determine whether, and in which patients, combination chemotherapy or novel agents, such as the epidermal growth factor receptor inhibitors or paclitaxel poliglumex, have advantages. Three large phase III trials-Selective Targeting for Efficacy in Lung Cancer, Lower Adverse Reactions trials (STELLAR)-are now being conducted in PS2 patients with NSCLC. It is hoped that their findings will aid in determining the best treatment options for these patients.

  6. The TEF modeling and analysis approach to advance thermionic space power technology

    NASA Astrophysics Data System (ADS)

    Marshall, Albert C.

    1997-01-01

    Thermionics space power systems have been proposed as advanced power sources for future space missions that require electrical power levels significantly above the capabilities of current space power systems. The Defense Special Weapons Agency's (DSWA) Thermionic Evaluation Facility (TEF) is carrying out both experimental and analytical research to advance thermionic space power technology to meet this expected need. A Modeling and Analysis (M&A) project has been created at the TEF to develop analysis tools, evaluate concepts, and guide research. M&A activities are closely linked to the TEF experimental program, providing experiment support and using experimental data to validate models. A planning exercise has been completed for the M&A project, and a strategy for implementation was developed. All M&A activities will build on a framework provided by a system performance model for a baseline Thermionic Fuel Element (TFE) concept. The system model is composed of sub-models for each of the system components and sub-systems. Additional thermionic component options and model improvements will continue to be incorporated in the basic system model during the course of the program. All tasks are organized into four focus areas: 1) system models, 2) thermionic research, 3) alternative concepts, and 4) documentation and integration. The M&A project will provide a solid framework for future thermionic system development.

  7. Electrochemical advanced oxidation and biological processes for wastewater treatment: a review of the combined approaches.

    PubMed

    Ganzenko, Oleksandra; Huguenot, David; van Hullebusch, Eric D; Esposito, Giovanni; Oturan, Mehmet A

    2014-01-01

    As pollution becomes one of the biggest environmental challenges of the twenty-first century, pollution of water threatens the very existence of humanity, making immediate action a priority. The most persistent and hazardous pollutants come from industrial and agricultural activities; therefore, effective treatment of this wastewater prior to discharge into the natural environment is the solution. Advanced oxidation processes (AOPs) have caused increased interest due to their ability to degrade hazardous substances in contrast to other methods, which mainly only transfer pollution from wastewater to sludge, a membrane filter, or an adsorbent. Among a great variety of different AOPs, a group of electrochemical advanced oxidation processes (EAOPs), including electro-Fenton, is emerging as an environmental-friendly and effective treatment process for the destruction of persistent hazardous contaminants. The only concern that slows down a large-scale implementation is energy consumption and related investment and operational costs. A combination of EAOPs with biological treatment is an interesting solution. In such a synergetic way, removal efficiency is maximized, while minimizing operational costs. The goal of this review is to present cutting-edge research for treatment of three common and problematic pollutants and effluents: dyes and textile wastewater, olive processing wastewater, and pharmaceuticals and hospital wastewater. Each of these types is regarded in terms of recent scientific research on individual electrochemical, individual biological and a combined synergetic treatment.

  8. Advanced enzymatic elimination of phenolic contaminants in wastewater: a nano approach at field scale.

    PubMed

    Gasser, Christoph A; Yu, Liang; Svojitka, Jan; Wintgens, Thomas; Ammann, Erik M; Shahgaldian, Patrick; Corvini, Philippe F-X; Hommes, Gregor

    2014-04-01

    The removal of recalcitrant chemicals in wastewater treatment systems is an increasingly relevant issue in industrialized countries. The elimination of persistent xenobiotics such as endocrine-disrupting chemicals (EDCs) emitted by municipal and industrial sewage treatment plants remains an unsolved challenge. The existing efficacious physico-chemical methods, such as advanced oxidation processes, are resource-intensive technologies. In this work, we investigated the possibility to remove phenolic EDCs [i.e., bisphenol A (BPA)] by means of a less energy and chemical consuming technology. To that end, cheap and resistant oxidative enzymes, i.e., laccases, were immobilized onto silica nanoparticles. The resulting nanobiocatalyst produced at kilogram scale was demonstrated to possess a broad substrate spectrum regarding the degradation of recalcitrant pollutants. This nanobiocatalyst was applied in a membrane reactor at technical scale for tertiary wastewater treatment. The system efficiently removed BPA and the results of long-term field tests illustrated the potential of fumed silica nanoparticles/laccase composites for advanced biological wastewater treatment.

  9. Selecton 2007: advanced models for detecting positive and purifying selection using a Bayesian inference approach.

    PubMed

    Stern, Adi; Doron-Faigenboim, Adi; Erez, Elana; Martz, Eric; Bacharach, Eran; Pupko, Tal

    2007-07-01

    Biologically significant sites in a protein may be identified by contrasting the rates of synonymous (K(s)) and non-synonymous (K(a)) substitutions. This enables the inference of site-specific positive Darwinian selection and purifying selection. We present here Selecton version 2.2 (http://selecton.bioinfo.tau.ac.il), a web server which automatically calculates the ratio between K(a) and K(s) (omega) at each site of the protein. This ratio is graphically displayed on each site using a color-coding scheme, indicating either positive selection, purifying selection or lack of selection. Selecton implements an assembly of different evolutionary models, which allow for statistical testing of the hypothesis that a protein has undergone positive selection. Specifically, the recently developed mechanistic-empirical model is introduced, which takes into account the physicochemical properties of amino acids. Advanced options were introduced to allow maximal fine tuning of the server to the user's specific needs, including calculation of statistical support of the omega values, an advanced graphic display of the protein's 3-dimensional structure, use of different genetic codes and inputting of a pre-built phylogenetic tree. Selecton version 2.2 is an effective, user-friendly and freely available web server which implements up-to-date methods for computing site-specific selection forces, and the visualization of these forces on the protein's sequence and structure.

  10. APPLICATION OF ADVANCED IN VITRO TECHNIQUES TO MEASURE, UNDERSTAND AND PREDICT THE KINETICS AND MECHANISMS OF XENOBIOTIC METABOLISM

    EPA Science Inventory

    We have developed a research program in metabolism that involves numerous collaborators across EPA as well as other federal and academic labs. A primary goal is to develop and apply advanced in vitro techniques to measure, understand and predict the kinetics and mechanisms of xen...

  11. Validation of multigroup neutron cross sections for the Advanced Neutron Source against the FOEHN critical experimental measurements

    SciTech Connect

    Smith, L.A.; Gehin, J.C.; Worley, B.A.; Renier, J.P.

    1994-04-01

    The FOEHN critical experiments were analyzed to validate the use of multigroup cross sections in the design of the Advanced Neutron Source. Eleven critical configurations were evaluated using the KENO, DORT, and VENTURE neutronics codes. Eigenvalue and power density profiles were computed and show very good agreement with measured values.

  12. Development of a Measure for Predicting Learning Advancement through Cooperative Education: Reliability and Validity of the PLACE Scale.

    ERIC Educational Resources Information Center

    Parks, Donald K.; Onwuegbuzie, Anthony J.; Cash, Shannon H.

    2001-01-01

    Exploratory factor analysis of data from 2,309 cooperative education students tested a measure of co-op outcomes. Three factors were identified: work skills development, career development, and academic functions. The Predicting Learner Advancement through Cooperative Education Scale appeared to have good psychometric properties. (Contains 27…

  13. Synthesizing Marketing, Community Engagement, and Systems Science Approaches for Advancing Translational Research.

    PubMed

    Kneipp, Shawn M; Leeman, Jennifer; McCall, Pamela; Hassmiller-Lich, Kristen; Bobashev, Georgiy; Schwartz, Todd A; Gilmore, Robert; Riggan, Scott; Gil, Benjamin

    2015-01-01

    The adoption and implementation of evidence-based interventions (EBIs) are the goals of translational research; however, potential end-users' perceptions of an EBI value have contributed to low rates of adoption. In this article, we describe our application of emerging dissemination and implementation science theoretical perspectives, community engagement, and systems science principles to develop a novel EBI dissemination approach. Using consumer-driven, graphics-rich simulation, the approach demonstrates predicted implementation effects on health and employment outcomes for socioeconomically disadvantaged women at the local level and is designed to increase adoption interest of county program managers accountable for improving these outcomes in their communities.

  14. Advances and applications of chance-constrained approaches to systems optimisation under uncertainty

    NASA Astrophysics Data System (ADS)

    Geletu, Abebe; Klöppel, Michael; Zhang, Hui; Li, Pu

    2013-07-01

    A chance-constrained optimisation (CCOPT) model has a dual goal: guaranteeing performance as well as system reliability under uncertainty. The beginning of CCOPT methods dates back in the 1950s. Recently, CCOPT approaches are gaining momentum as modern engineering and finance applications are forced to consider reliability and risk metrics at the design and planning stages. Although theoretical development and practical applications have been made, many open problems remain to be addressed in this area. This article attempts to provide a brief survey of major application areas, structure properties, challenges and solution approaches to CCOPT. In particular, we present our research results achieved in the past few years.

  15. Synthesizing Marketing, Community Engagement, and Systems Science Approaches for Advancing Translational Research.

    PubMed

    Kneipp, Shawn M; Leeman, Jennifer; McCall, Pamela; Hassmiller-Lich, Kristen; Bobashev, Georgiy; Schwartz, Todd A; Gilmore, Robert; Riggan, Scott; Gil, Benjamin

    2015-01-01

    The adoption and implementation of evidence-based interventions (EBIs) are the goals of translational research; however, potential end-users' perceptions of an EBI value have contributed to low rates of adoption. In this article, we describe our application of emerging dissemination and implementation science theoretical perspectives, community engagement, and systems science principles to develop a novel EBI dissemination approach. Using consumer-driven, graphics-rich simulation, the approach demonstrates predicted implementation effects on health and employment outcomes for socioeconomically disadvantaged women at the local level and is designed to increase adoption interest of county program managers accountable for improving these outcomes in their communities. PMID:26244479

  16. The genetic drift inventory: a tool for measuring what advanced undergraduates have mastered about genetic drift.

    PubMed

    Price, Rebecca M; Andrews, Tessa C; McElhinny, Teresa L; Mead, Louise S; Abraham, Joel K; Thanukos, Anna; Perez, Kathryn E

    2014-01-01

    Understanding genetic drift is crucial for a comprehensive understanding of biology, yet it is difficult to learn because it combines the conceptual challenges of both evolution and randomness. To help assess strategies for teaching genetic drift, we have developed and evaluated the Genetic Drift Inventory (GeDI), a concept inventory that measures upper-division students' understanding of this concept. We used an iterative approach that included extensive interviews and field tests involving 1723 students across five different undergraduate campuses. The GeDI consists of 22 agree-disagree statements that assess four key concepts and six misconceptions. Student scores ranged from 4/22 to 22/22. Statements ranged in mean difficulty from 0.29 to 0.80 and in discrimination from 0.09 to 0.46. The internal consistency, as measured with Cronbach's alpha, ranged from 0.58 to 0.88 across five iterations. Test-retest analysis resulted in a coefficient of stability of 0.82. The true-false format means that the GeDI can test how well students grasp key concepts central to understanding genetic drift, while simultaneously testing for the presence of misconceptions that indicate an incomplete understanding of genetic drift. The insights gained from this testing will, over time, allow us to improve instruction about this key component of evolution.

  17. Advancement in polarimetric glucose sensing: simulation and measurement of birefringence properties of cornea

    NASA Astrophysics Data System (ADS)

    Malik, Bilal H.; Coté, Gerard L.

    2011-03-01

    Clinical guidelines dictate that frequent blood glucose monitoring in diabetic patients is critical towards proper management of the disease. Although, several different types of glucose monitors are now commercially available, most of these devices are invasive, thereby adversely affecting patient compliance. To this end, optical polarimetric glucose sensing through the eye has been proposed as a potential noninvasive means to aid in the control of diabetes. Arguably, the most critical and limiting factor towards successful application of such a technique is the time varying corneal birefringence due to eye motion artifact. We present a spatially variant uniaxial eye model to serve as a tool towards better understanding of the cornea's birefringence properties. The simulations show that index-unmatched coupling of light is spatially limited to a smaller range when compared to the index-matched situation. Polarimetric measurements on rabbits' eyes indicate relative agreement between the modeled and experimental values of corneal birefringence. In addition, the observed rotation in the plane of polarized light for multiple wavelengths demonstrates the potential for using a dual-wavelength polarimetric approach to overcome the noise due to timevarying corneal birefringence. These results will ultimately aid us in the development of an appropriate eye coupling mechanism for in vivo polarimetric glucose measurements.

  18. Cholesterol homeostasis in cardiovascular disease and recent advances in measuring cholesterol signatures.

    PubMed

    Seo, Hong Seog; Choi, Man Ho

    2015-09-01

    Despite the biochemical importance of cholesterol, its abnormal metabolism has serious cellular consequences that lead to endocrine disorders such as cardiovascular disease (CVD). Nevertheless, the impact of blood cholesterol as a CVD risk factor is still debated, and treatment with cholesterol-lowering drugs remains controversial, particularly in older patients. Although, the prevalence of CVD increases with age, the underlying mechanisms for this phenomenon are not well understood, and metabolic changes have not been confirmed as predisposing factors of atherogenesis. The quantification of circulating biomarkers for cholesterol homeostasis is therefore warranted, and reference values for cholesterol absorption and synthesis should be determined in order to establish CVD risk factors. The traditional lipid profile is often derived rather than directly measured and lacks a universal standard to interpret the results. In contrast, mass spectrometry-based cholesterol profiling can accurately measure free cholesterol as a biologically active component. This approach allows to detect alterations in various metabolic pathways that control cholesterol homeostasis, by quantitative analysis of cholesterol and its precursors/metabolites as well as dietary sterols. An overview of the mechanism of cholesterol homeostasis under different physiological conditions may help to identify predictive biomarkers of concomitant atherosclerosis and conventional CVD risk factors.

  19. Metrology of a mirror at the Advanced Photon Source : comparison between optical and x-ray measurements.

    SciTech Connect

    Assoufid, L.

    1998-10-14

    This paper describes metrology of a vertically focusing mirror on the bending magnet beamline in sector-1 of the Advanced Photon Source, Argonne National Laboratory. The mirror was evaluated using measurements from both an optical long trace profiler and x-rays. Slope error profiles obtained with the two methods were compared and were found to be in a good agreement. Further comparisons were made between x-ray measurements and results from the SHADOW ray-tracing code.

  20. Who is afraid of POV measures? Unified approach to quantum phase observables

    SciTech Connect

    Busch, P. |; Grabowski, M.; Lahti, P.J.

    1995-01-01

    It is shown that introducing phase observables as shift-covariant positive-operator-valued measures yields a coherent unification of various conceptually different approaches to the phase in quantum theory. {copyright} 1995 Academic Press, Inc.

  1. A Characteristics-Based Approach to Radioactive Waste Classification in Advanced Nuclear Fuel Cycles

    NASA Astrophysics Data System (ADS)

    Djokic, Denia

    The radioactive waste classification system currently used in the United States primarily relies on a source-based framework. This has lead to numerous issues, such as wastes that are not categorized by their intrinsic risk, or wastes that do not fall under a category within the framework and therefore are without a legal imperative for responsible management. Furthermore, in the possible case that advanced fuel cycles were to be deployed in the United States, the shortcomings of the source-based classification system would be exacerbated: advanced fuel cycles implement processes such as the separation of used nuclear fuel, which introduce new waste streams of varying characteristics. To be able to manage and dispose of these potential new wastes properly, development of a classification system that would assign appropriate level of management to each type of waste based on its physical properties is imperative. This dissertation explores how characteristics from wastes generated from potential future nuclear fuel cycles could be coupled with a characteristics-based classification framework. A static mass flow model developed under the Department of Energy's Fuel Cycle Research & Development program, called the Fuel-cycle Integration and Tradeoffs (FIT) model, was used to calculate the composition of waste streams resulting from different nuclear fuel cycle choices: two modified open fuel cycle cases (recycle in MOX reactor) and two different continuous-recycle fast reactor recycle cases (oxide and metal fuel fast reactors). This analysis focuses on the impact of waste heat load on waste classification practices, although future work could involve coupling waste heat load with metrics of radiotoxicity and longevity. The value of separation of heat-generating fission products and actinides in different fuel cycles and how it could inform long- and short-term disposal management is discussed. It is shown that the benefits of reducing the short-term fission

  2. Measurement of fracture toughness by nanoindentation methods: Recent advances and future challenges

    SciTech Connect

    Sebastiani, Marco; Johanns, K. E.; Herbert, Erik G.; Pharr, George M.

    2015-04-30

    In this study, we describe recent advances and developments for the measurement of fracture toughness at small scales by the use of nanoindentation-based methods including techniques based on micro-cantilever beam bending and micro-pillar splitting. A critical comparison of the techniques is made by testing a selected group of bulk and thin film materials. For pillar splitting, cohesive zone finite element simulations are used to validate a simple relationship between the critical load at failure, the pillar radius, and the fracture toughness for a range of material properties and coating/substrate combinations. The minimum pillar diameter required for nucleation and growth of a crack during indentation is also estimated. An analysis of pillar splitting for a film on a dissimilar substrate material shows that the critical load for splitting is relatively insensitive to the substrate compliance for a large range of material properties. Experimental results from a selected group of materials show good agreement between single cantilever and pillar splitting methods, while a discrepancy of ~25% is found between the pillar splitting technique and double-cantilever testing. It is concluded that both the micro-cantilever and pillar splitting techniques are valuable methods for micro-scale assessment of fracture toughness of brittle ceramics, provided the underlying assumptions can be validated. Although the pillar splitting method has some advantages because of the simplicity of sample preparation and testing, it is not applicable to most metals because their higher toughness prevents splitting, and in this case, micro-cantilever bend testing is preferred.

  3. Measurement of fracture toughness by nanoindentation methods: Recent advances and future challenges

    DOE PAGES

    Sebastiani, Marco; Johanns, K. E.; Herbert, Erik G.; Pharr, George M.

    2015-04-30

    In this study, we describe recent advances and developments for the measurement of fracture toughness at small scales by the use of nanoindentation-based methods including techniques based on micro-cantilever beam bending and micro-pillar splitting. A critical comparison of the techniques is made by testing a selected group of bulk and thin film materials. For pillar splitting, cohesive zone finite element simulations are used to validate a simple relationship between the critical load at failure, the pillar radius, and the fracture toughness for a range of material properties and coating/substrate combinations. The minimum pillar diameter required for nucleation and growth ofmore » a crack during indentation is also estimated. An analysis of pillar splitting for a film on a dissimilar substrate material shows that the critical load for splitting is relatively insensitive to the substrate compliance for a large range of material properties. Experimental results from a selected group of materials show good agreement between single cantilever and pillar splitting methods, while a discrepancy of ~25% is found between the pillar splitting technique and double-cantilever testing. It is concluded that both the micro-cantilever and pillar splitting techniques are valuable methods for micro-scale assessment of fracture toughness of brittle ceramics, provided the underlying assumptions can be validated. Although the pillar splitting method has some advantages because of the simplicity of sample preparation and testing, it is not applicable to most metals because their higher toughness prevents splitting, and in this case, micro-cantilever bend testing is preferred.« less

  4. An Active Learning Approach to Teach Advanced Multi-Predictor Modeling Concepts to Clinicians

    ERIC Educational Resources Information Center

    Samsa, Gregory P.; Thomas, Laine; Lee, Linda S.; Neal, Edward M.

    2012-01-01

    Clinicians have characteristics--high scientific maturity, low tolerance for symbol manipulation and programming, limited time outside of class--that limit the effectiveness of traditional methods for teaching multi-predictor modeling. We describe an active-learning based approach that shows particular promise for accommodating these…

  5. Performed Culture: An Approach to East Asian Language Pedagogy. Pathways to Advanced Skills Series, Volume 11

    ERIC Educational Resources Information Center

    Christensen, Matthew; Warnick, Paul

    2006-01-01

    This book is a general introduction to the performed culture approach, which trains students how to express themselves in a way that native speakers of the target culture feel appropriate in given situations. Target readership includes Chinese, Japanese, and Korean language teachers and graduate students. Chapters of this book include: (1)…

  6. The Hundred Languages of Children: The Reggio Emilia Approach--Advanced Reflections. Second Edition.

    ERIC Educational Resources Information Center

    Edwards, Carolyn, Ed.; Gandini, Lella, Ed.; Forman, George, Ed.

    This collection of essays and interviews documents the unique approach to early childhood education taken by schools in the Reggio Emilia region of Italy. Howard Gardner and David Hawkins provide reflections in chapters that begin the book. The book is then divided into four major parts. Part I includes an introduction by Carolyn Edwards and…

  7. Aspects of a Neoteric Approach to Advance Students' Ability to Conjecture, Prove, or Disprove

    ERIC Educational Resources Information Center

    McLoughlin, M. Padraig M. M.

    2010-01-01

    The author of this paper suggests several neoteric, unconventional, idiosyncratic, or unique approaches to beginning Set Theory that he found seems to work well in building students' introductory understanding of the Foundations of Mathematics. This paper offers some ideas on how the author uses certain "unconventional" definitions and "standards"…

  8. Advanced multi-frequency radar: Design, preliminary measurements and particle size distribution retrieval

    NASA Astrophysics Data System (ADS)

    Majurec, Ninoslav

    In the spring of 2001 the Microwave Remote Sensing Laboratory (MIRSL) at the University of Massachusetts began the development of an advanced Multi-Frequency Radar (AMFR) system for studying clouds and precipitation. This mobile radar was designed to consist of three polarimetric Doppler subsystems operating at Ku-band (13.4 GHz), Ka-band (35.6 GHz) and W-band (94.92 GHz). This combination of frequency bands allows a measurement of a wide range of atmospheric targets ranging from weakly reflecting clouds to strong precipitation. The antenna beamwidths at each frequency were intentionally matched, ensuring consistent sampling volume. Multi-frequency radar remote sensing techniques are not widely used because few multi-frequency radars are available to the science community. One exception is the 33 GHz/95 GHz UMass Cloud Profiling Radar System (CPRS), which AMFR is intended to replace. AMFR's multi-parameter capabilities are designed for characterizing the complex microphysics of layer clouds and precipitation processes in winter storms. AMFR will also play an important role in developing algorithms and validating measurements for an upcoming generation of space-borne radars. The frequency bands selected for AMFR match those of several sensors that have been deployed or are under development. These include the Japanese Aerospace Exploration Agencies (JAXA's) Tropical Rainfall Measuring Mission (TRMM) satellite Ku-band (13 GHz) radar, the CloudSat W-band (95 GHz) radar, and the Global Precipitation Mission (GPM) satellite radars at Ku-band and Ka-band. This dissertation describes the AMFR hardware design and development. Compared to CPRS, the addition of one extra frequency band (Ku) will extend AMFR's measurement capabilities towards the larger particle sizes (precipitation). AMFR's design is based around high-power klystron amplifiers. This ensures complete coherency (CPRS uses magnetrons and coherent-on-receive technique). The partial loss in sensitivity due to

  9. The Effects of Different Pedagogical Approaches on the Learning of Length Measurement in Kindergarten

    ERIC Educational Resources Information Center

    Kotsopoulos, Donna; Makosz, Samantha; Zambrzycka, Joanna; McCarthy, Katharine

    2015-01-01

    This research investigated the effects of different pedagogical approaches on the learning of length measurement in kindergarten children. Specifically examined were the pedagogical approaches of guided instruction, center-based learning, and free exploration in the context of a play-based learning environment. This mixed design research was…

  10. Developing a Fidelity of Implementation Measure for the "Responsive Classroom" Approach

    ERIC Educational Resources Information Center

    Nathanson, Lori

    2009-01-01

    This study examines the psychometric properties, reliability, and validity of a measure designed to assess fidelity of implementation of the "Responsive Classroom"[R] ("RC") approach. The Classroom Practices Teacher Survey (CPTS) assesses teachers' use of the "RC" approach, a social and emotional learning (SEL) intervention currently under…

  11. Advanced Spatial-Division Multiplexed Measurement Systems Propositions-From Telecommunication to Sensing Applications: A Review.

    PubMed

    Weng, Yi; Ip, Ezra; Pan, Zhongqi; Wang, Ting

    2016-01-01

    The concepts of spatial-division multiplexing (SDM) technology were first proposed in the telecommunications industry as an indispensable solution to reduce the cost-per-bit of optical fiber transmission. Recently, such spatial channels and modes have been applied in optical sensing applications where the returned echo is analyzed for the collection of essential environmental information. The key advantages of implementing SDM techniques in optical measurement systems include the multi-parameter discriminative capability and accuracy improvement. In this paper, to help readers without a telecommunication background better understand how the SDM-based sensing systems can be incorporated, the crucial components of SDM techniques, such as laser beam shaping, mode generation and conversion, multimode or multicore elements using special fibers and multiplexers are introduced, along with the recent developments in SDM amplifiers, opto-electronic sources and detection units of sensing systems. The examples of SDM-based sensing systems not only include Brillouin optical time-domain reflectometry or Brillouin optical time-domain analysis (BOTDR/BOTDA) using few-mode fibers (FMF) and the multicore fiber (MCF) based integrated fiber Bragg grating (FBG) sensors, but also involve the widely used components with their whole information used in the full multimode constructions, such as the whispering gallery modes for fiber profiling and chemical species measurements, the screw/twisted modes for examining water quality, as well as the optical beam shaping to improve cantilever deflection measurements. Besides, the various applications of SDM sensors, the cost efficiency issue, as well as how these complex mode multiplexing techniques might improve the standard fiber-optic sensor approaches using single-mode fibers (SMF) and photonic crystal fibers (PCF) have also been summarized. Finally, we conclude with a prospective outlook for the opportunities and challenges of SDM

  12. Advanced Spatial-Division Multiplexed Measurement Systems Propositions—From Telecommunication to Sensing Applications: A Review

    PubMed Central

    Weng, Yi; Ip, Ezra; Pan, Zhongqi; Wang, Ting

    2016-01-01

    The concepts of spatial-division multiplexing (SDM) technology were first proposed in the telecommunications industry as an indispensable solution to reduce the cost-per-bit of optical fiber transmission. Recently, such spatial channels and modes have been applied in optical sensing applications where the returned echo is analyzed for the collection of essential environmental information. The key advantages of implementing SDM techniques in optical measurement systems include the multi-parameter discriminative capability and accuracy improvement. In this paper, to help readers without a telecommunication background better understand how the SDM-based sensing systems can be incorporated, the crucial components of SDM techniques, such as laser beam shaping, mode generation and conversion, multimode or multicore elements using special fibers and multiplexers are introduced, along with the recent developments in SDM amplifiers, opto-electronic sources and detection units of sensing systems. The examples of SDM-based sensing systems not only include Brillouin optical time-domain reflectometry or Brillouin optical time-domain analysis (BOTDR/BOTDA) using few-mode fibers (FMF) and the multicore fiber (MCF) based integrated fiber Bragg grating (FBG) sensors, but also involve the widely used components with their whole information used in the full multimode constructions, such as the whispering gallery modes for fiber profiling and chemical species measurements, the screw/twisted modes for examining water quality, as well as the optical beam shaping to improve cantilever deflection measurements. Besides, the various applications of SDM sensors, the cost efficiency issue, as well as how these complex mode multiplexing techniques might improve the standard fiber-optic sensor approaches using single-mode fibers (SMF) and photonic crystal fibers (PCF) have also been summarized. Finally, we conclude with a prospective outlook for the opportunities and challenges of SDM

  13. Advanced Spatial-Division Multiplexed Measurement Systems Propositions-From Telecommunication to Sensing Applications: A Review.

    PubMed

    Weng, Yi; Ip, Ezra; Pan, Zhongqi; Wang, Ting

    2016-01-01

    The concepts of spatial-division multiplexing (SDM) technology were first proposed in the telecommunications industry as an indispensable solution to reduce the cost-per-bit of optical fiber transmission. Recently, such spatial channels and modes have been applied in optical sensing applications where the returned echo is analyzed for the collection of essential environmental information. The key advantages of implementing SDM techniques in optical measurement systems include the multi-parameter discriminative capability and accuracy improvement. In this paper, to help readers without a telecommunication background better understand how the SDM-based sensing systems can be incorporated, the crucial components of SDM techniques, such as laser beam shaping, mode generation and conversion, multimode or multicore elements using special fibers and multiplexers are introduced, along with the recent developments in SDM amplifiers, opto-electronic sources and detection units of sensing systems. The examples of SDM-based sensing systems not only include Brillouin optical time-domain reflectometry or Brillouin optical time-domain analysis (BOTDR/BOTDA) using few-mode fibers (FMF) and the multicore fiber (MCF) based integrated fiber Bragg grating (FBG) sensors, but also involve the widely used components with their whole information used in the full multimode constructions, such as the whispering gallery modes for fiber profiling and chemical species measurements, the screw/twisted modes for examining water quality, as well as the optical beam shaping to improve cantilever deflection measurements. Besides, the various applications of SDM sensors, the cost efficiency issue, as well as how these complex mode multiplexing techniques might improve the standard fiber-optic sensor approaches using single-mode fibers (SMF) and photonic crystal fibers (PCF) have also been summarized. Finally, we conclude with a prospective outlook for the opportunities and challenges of SDM

  14. Advanced Sine Wave Modulation of Continuous Wave Laser System for Atmospheric CO2 Differential Absorption Measurements

    NASA Technical Reports Server (NTRS)

    Campbell, Joel F.; Lin, Bing; Nehrir, Amin R.

    2014-01-01

    NASA Langley Research Center in collaboration with ITT Exelis have been experimenting with Continuous Wave (CW) laser absorption spectrometer (LAS) as a means of performing atmospheric CO2 column measurements from space to support the Active Sensing of CO2 Emissions over Nights, Days, and Seasons (ASCENDS) mission.Because range resolving Intensity Modulated (IM) CW lidar techniques presented here rely on matched filter correlations, autocorrelation properties without side lobes or other artifacts are highly desirable since the autocorrelation function is critical for the measurements of lidar return powers, laser path lengths, and CO2 column amounts. In this paper modulation techniques are investigated that improve autocorrelation properties. The modulation techniques investigated in this paper include sine waves modulated by maximum length (ML) sequences in various hardware configurations. A CW lidar system using sine waves modulated by ML pseudo random noise codes is described, which uses a time shifting approach to separate channels and make multiple, simultaneous online/offline differential absorption measurements. Unlike the pure ML sequence, this technique is useful in hardware that is band pass filtered as the IM sine wave carrier shifts the main power band. Both amplitude and Phase Shift Keying (PSK) modulated IM carriers are investigated that exibit perfect autocorrelation properties down to one cycle per code bit. In addition, a method is presented to bandwidth limit the ML sequence based on a Gaussian filter implemented in terms of Jacobi theta functions that does not seriously degrade the resolution or introduce side lobes as a means of reducing aliasing and IM carrier bandwidth.

  15. A systematic approach to advanced cockpit warning systems for air transport operations: Line pilot preferences

    NASA Technical Reports Server (NTRS)

    Williams, D. H.; Simpson, C. A.

    1976-01-01

    Line pilots (fifty captains, first officers, and flight engineers) from 8 different airlines were administered a structured questionnaire relating to future warning system design and solutions to current warning system problems. This was followed by a semantic differential to obtain a factor analysis of 18 different cockpit warning signals on scales such as informative/distracting, annoying/soothing. Half the pilots received a demonstration of the experimental text and voice synthesizer warning systems before answering the questionnaire and the semantic differential. A control group answered the questionnaire and the semantic differential first, thus providing a check for the stability of pilot preferences with and without actual exposure to experimental systems. Generally, the preference data obtained revealed much consistency and strong agreement among line pilots concerning advance cockpit warning system design.

  16. Adjuvant paclitaxel and carboplatin chemotherapy with involved field radiation in advanced endometrial cancer: A sequential approach

    SciTech Connect

    Lupe, Krystine; Kwon, Janice . E-mail: Janice.kwon@lhsc.on.ca; D'Souza, David; Gawlik, Christine; Stitt, Larry; Whiston, Frances; Nascu, Patricia; Wong, Eugene; Carey, Mark S.

    2007-01-01

    Purpose: To determine the feasibility of adjuvant paclitaxel and carboplatin chemotherapy interposed with involved field radiotherapy for women with advanced endometrial cancer. Methods and Materials: This was a prospective cohort study of women with Stage III and IV endometrial cancer. Adjuvant therapy consisted of 4 cycles of paclitaxel (175 mg/m{sup 2}) and carboplatin (350 mg/m{sup 2}) every 3 weeks, followed sequentially by external beam radiotherapy (RT) to the pelvis (45 Gy), followed by an additional two cycles of chemotherapy. Para-aortic RT and/or HDR vault brachytherapy (BT) were added at the discretion of the treating physician. Results: Thirty-three patients (median age, 63 years) received treatment between April 2002 and June 2005. Median follow-up was 21 months. Stage distribution was as follows: IIIA (21%), IIIC (70%), IVB (9%). Combination chemotherapy was successfully administered to 30 patients (91%) and 25 patients (76%), before and after RT respectively. Nine patients (27%) experienced acute Grade 3 or 4 chemotherapy toxicities. All patients completed pelvic RT; 19 (58%) received standard 4-field RT and 14 (42%) received intensity-modulated radiotherapy. Ten (30%) received extended field radiation. Four patients (12%) experienced acute Grade 3 or 4 RT toxicities. Six (18%) patients developed chronic RT toxicity. There were no treatment-related deaths. Two-year disease-free and overall survival rates were both 55%. There was only one pelvic relapse (3%). Conclusions: Adjuvant treatment with combination chemotherapy interposed with involved field radiation in advanced endometrial cancer was well tolerated. This protocol may be suitable for further evaluation in a clinical trial.

  17. Advanced Fabrication Method for the Preparation of MOF Thin Films: Liquid-Phase Epitaxy Approach Meets Spin Coating Method.

    PubMed

    Chernikova, Valeriya; Shekhah, Osama; Eddaoudi, Mohamed

    2016-08-10

    Here, we report a new and advanced method for the fabrication of highly oriented/polycrystalline metal-organic framework (MOF) thin films. Building on the attractive features of the liquid-phase epitaxy (LPE) approach, a facile spin coating method was implemented to generate MOF thin films in a high-throughput fashion. Advantageously, this approach offers a great prospective to cost-effectively construct thin-films with a significantly shortened preparation time and a lessened chemicals and solvents consumption, as compared to the conventional LPE-process. Certainly, this new spin-coating approach has been implemented successfully to construct various MOF thin films, ranging in thickness from a few micrometers down to the nanometer scale, spanning 2-D and 3-D benchmark MOF materials including Cu2(bdc)2·xH2O, Zn2(bdc)2·xH2O, HKUST-1, and ZIF-8. This method was appraised and proved effective on a variety of substrates comprising functionalized gold, silicon, glass, porous stainless steel, and aluminum oxide. The facile, high-throughput and cost-effective nature of this approach, coupled with the successful thin film growth and substrate versatility, represents the next generation of methods for MOF thin film fabrication. Therefore, paving the way for these unique MOF materials to address a wide range of challenges in the areas of sensing devices and membrane technology. PMID:27415640

  18. Advancing Dose-Response Assessment Methods for Environmental Regulatory Impact Analysis: A Bayesian Belief Network Approach Applied to Inorganic Arsenic

    PubMed Central

    Zabinski, Joseph W.; Garcia-Vargas, Gonzalo; Rubio-Andrade, Marisela; Fry, Rebecca C.; Gibson, Jacqueline MacDonald

    2016-01-01

    Dose-response functions used in regulatory risk assessment are based on studies of whole organisms and fail to incorporate genetic and metabolomic data. Bayesian belief networks (BBNs) could provide a powerful framework for incorporating such data, but no prior research has examined this possibility. To address this gap, we develop a BBN-based model predicting birthweight at gestational age from arsenic exposure via drinking water and maternal metabolic indicators using a cohort of 200 pregnant women from an arsenic-endemic region of Mexico. We compare BBN predictions to those of prevailing slope-factor and reference-dose approaches. The BBN outperforms prevailing approaches in balancing false-positive and false-negative rates. Whereas the slope-factor approach had 2% sensitivity and 99% specificity and the reference-dose approach had 100% sensitivity and 0% specificity, the BBN's sensitivity and specificity were 71% and 30%, respectively. BBNs offer a promising opportunity to advance health risk assessment by incorporating modern genetic and metabolomic data.

  19. An overview of surgery-first approach: Recent advances in orthognathic surgery.

    PubMed

    Sharma, Vipul Kumar; Yadav, Kirti; Tandon, Pradeep

    2015-01-01

    The disadvantages of having orthodontic interventions both before and after orthognathic surgery include a long treatment time of 7-47 months and temporary worsening of facial appearance. Nowadays, the concept of surgery-first, followed by orthodontic treatment is applied to orthognathic surgery cases in different orthodontic centers in the world. This concept and technique is called "surgery-first-orthognathic-approach" or "surgery-first approach" (SFA) rigid fixation (skeletal anchorage system) of the bony segments and regional acceleratory phenomenon were keys to broad implementation of the SFA. This article is intended to provide an overview of SFA including indications, general and specific guidelines, different protocol variations, success rate and potential problems.

  20. Advanced material and approach for metal ions removal from aqueous solutions

    NASA Astrophysics Data System (ADS)

    Turhanen, Petri A.; Vepsäläinen, Jouko J.; Peräniemi, Sirpa

    2015-03-01

    A Novel approach to remove metals from aqueous solutions has been developed. The method is based on a resin free, solid, non-toxic, microcrystalline bisphosphonate material, which has very low solubility in water (59 mg/l to ion free Milli-Q water and 13 mg/l to 3.5% NaCl solution). The material has been produced almost quantitatively on a 1 kg scale (it has been prepared also on a pilot scale, ca. 7 kg) and tested successfully for its ability to collect metal cations from different sources, such as ground water and mining process waters. Not only was this material highly efficient at collecting several metal ions out of solution it also proved to be regenerable and reusable over a number of adsorption/desorption, which is crucial for environmental friendliness. This material has several advantages compared to the currently used approaches, such as no need for any precipitation step.