Surgical treatment in stenosing rectal cancer.

PubMed

Deaconescu, V; Simion, L; Alecu, M; Ionescu, S; Mastalier, B; Straja, N D

2014-01-01

Rectal cancer represents an important health issue, which involves multidisciplinary treatment, posing a major surgical challenge, both in terms of diagnosis and treatment. Between 2009-2013, we analysed 83 patients with stenosing rectal cancer operated on at the Clinic of General Surgery II of Colentina Clinical Hospital and at the Clinic of General Surgery I of "Prof. Dr. Al. Trestioreanu"€ Oncology Institute, in Bucharest. Gender distribution was: 51 males and 32 females. Average age was 65 years old. The most frequently encountered symptoms were colicky abdominal pain and rectorrhagia. 25 patients presented intestinal occlusion phenomena at admission, the other 58 cases being in subocclusive stage. In occlusive stages: 17 patients presented with resectable tumour, while 8 patients had locally advanced neoplastic forms (€œfrozen pelvis€), left iliac colostomy with tumour biopsy being the chosen approach. In subocclusive stages: 5 cases had unresectable tumours for which left iliac anus with tumour biopsy was performed; 53 cases presented with resectable tumour, for which the Hartmann procedure (12 patients) and left iliac colostomy with tumour biopsy (41 patients) were performed. Depending on the histopathological result, patients were submitted to radio- and chemotherapy.Tumour resection was possible in 70 cases (84.33%), only 34 of these (40.96%) being with radical intent. Treatment for stenosing rectal cancer is multimodal,represented by surgical approach, radio- and chemotherapy. The rationality behind surgery as a first therapeutic gesture in the given study group was represented by the need to treat occlusive type complications, patients benefitting subsequently from radio- and chemotherapy. The opportunity of a second surgical intervention, with the objective to remove the tumour, was established based on the therapeutic response to radio- and chemotherapy. Celsius.

Struggle for Social Position in Digital Media Composition

ERIC Educational Resources Information Center

Doerr-Stevens, Candance

2013-01-01

This study investigates the processes and products of multimodal and multi-authored digital media composition. Using ethnographic case study and Mediated Discourse Analysis (Norris & Jones, 2005), this study focuses specifically on the digital media composition of radio and film documentaries, examining struggle among students, media, and…

Contemporary Multi-Modal Historical Representations and the Teaching of Disciplinary Understandings in History

ERIC Educational Resources Information Center

Donnelly, Debra J.

2018-01-01

Traditional privileging of the printed text has been considerably eroded by rapid technological advancement and in Australia, as elsewhere, many History teaching programs feature an array of multi-modal historical representations. Research suggests that engagement with the visual and multi-modal constructs has the potential to enrich the pedagogy…

Reconfigurable radio receiver with fractional sample rate converter and multi-rate ADC based on LO-derived sampling clock

NASA Astrophysics Data System (ADS)

Park, Sungkyung; Park, Chester Sungchung

2018-03-01

A composite radio receiver back-end and digital front-end, made up of a delta-sigma analogue-to-digital converter (ADC) with a high-speed low-noise sampling clock generator, and a fractional sample rate converter (FSRC), is proposed and designed for a multi-mode reconfigurable radio. The proposed radio receiver architecture contributes to saving the chip area and thus lowering the design cost. To enable inter-radio access technology handover and ultimately software-defined radio reception, a reconfigurable radio receiver consisting of a multi-rate ADC with its sampling clock derived from a local oscillator, followed by a rate-adjustable FSRC for decimation, is designed. Clock phase noise and timing jitter are examined to support the effectiveness of the proposed radio receiver. A FSRC is modelled and simulated with a cubic polynomial interpolator based on Lagrange method, and its spectral-domain view is examined in order to verify its effect on aliasing, nonlinearity and signal-to-noise ratio, giving insight into the design of the decimation chain. The sampling clock path and the radio receiver back-end data path are designed in a 90-nm CMOS process technology with 1.2V supply.

MO-DE-202-01: Image-Guided Focused Ultrasound Surgery and Therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farahani, K.

At least three major trends in surgical intervention have emerged over the last decade: a move toward more minimally invasive (or non-invasive) approach to the surgical target; the development of high-precision treatment delivery techniques; and the increasing role of multi-modality intraoperative imaging in support of such procedures. This symposium includes invited presentations on recent advances in each of these areas and the emerging role for medical physics research in the development and translation of high-precision interventional techniques. The four speakers are: Keyvan Farahani, “Image-guided focused ultrasound surgery and therapy” Jeffrey H. Siewerdsen, “Advances in image registration and reconstruction for image-guidedmore » neurosurgery” Tina Kapur, “Image-guided surgery and interventions in the advanced multimodality image-guided operating (AMIGO) suite” Raj Shekhar, “Multimodality image-guided interventions: Multimodality for the rest of us” Learning Objectives: Understand the principles and applications of HIFU in surgical ablation. Learn about recent advances in 3D–2D and 3D deformable image registration in support of surgical safety and precision. Learn about recent advances in model-based 3D image reconstruction in application to intraoperative 3D imaging. Understand the multi-modality imaging technologies and clinical applications investigated in the AMIGO suite. Understand the emerging need and techniques to implement multi-modality image guidance in surgical applications such as neurosurgery, orthopaedic surgery, vascular surgery, and interventional radiology. Research supported by the NIH and Siemens Healthcare.; J. Siewerdsen; Grant Support - National Institutes of Health; Grant Support - Siemens Healthcare; Grant Support - Carestream Health; Advisory Board - Carestream Health; Licensing Agreement - Carestream Health; Licensing Agreement - Elekta Oncology.; T. Kapur, P41EB015898; R. Shekhar, Funding: R42CA137886 and R41CA192504 Disclosure and CoI: IGI Technologies, small-business partner on the grants.« less

Clinical effectiveness of multimodality treatment on advanced pediatric hepatoblastoma.

PubMed

Zhang, Y; Zhang, W-L; Huang, D-S; Hong, L; Wang, Y-Z; Zhu, X; Hu, H-M; Zhang, P-W; Yi, Y; Han, T

2014-01-01

To investigate the effect of multimodality treatment of advanced paediatric hepatoblastoma and the factors affecting the prognosis. 35 childhood patients were treated with multimodality treatments consisting of chemotherapy, surgery, interventional therapy, and autologous peripheral blood stem cell transplantation. Patients were followed up every month. 33 patients completed the follow-up, of which 17 were in complete remission, 5 were in partial remission, 1 case got worse, and 10 died. The remission rate was 66.7% (22/33), and the overall survival rate was 69.7% (23/33). 1 patient with advanced hepatoblastoma got high-dose chemotherapy combined with autologous peripheral blood stem cell transplantation (APBSCT) treatment, and a primary lesion by 18 x 15 x 9 cm reduced to 10 x 8 x 4 cm. Remote metastases significantly alleviated, and partial remission reached six months. The overall survival was 9 months after transplantation. Patients with the mixed phenotype of hepatoblastoma had a worse prognosis than with the epithelial phenotype (p < 0.001), and patients in stage IV had a lower survival rate than in stage III (p < 0.001). Multimodality treatment can effectively improve remission rate and prolong the survival of children with the advanced hepatoblastoma. In addition, alpha-fetoprotein (AFP), hepatoblastoma pathological classification and staging are of great use in prediction of prognosis.

Quantitative multimodality imaging in cancer research and therapy.

PubMed

Yankeelov, Thomas E; Abramson, Richard G; Quarles, C Chad

2014-11-01

Advances in hardware and software have enabled the realization of clinically feasible, quantitative multimodality imaging of tissue pathophysiology. Earlier efforts relating to multimodality imaging of cancer have focused on the integration of anatomical and functional characteristics, such as PET-CT and single-photon emission CT (SPECT-CT), whereas more-recent advances and applications have involved the integration of multiple quantitative, functional measurements (for example, multiple PET tracers, varied MRI contrast mechanisms, and PET-MRI), thereby providing a more-comprehensive characterization of the tumour phenotype. The enormous amount of complementary quantitative data generated by such studies is beginning to offer unique insights into opportunities to optimize care for individual patients. Although important technical optimization and improved biological interpretation of multimodality imaging findings are needed, this approach can already be applied informatively in clinical trials of cancer therapeutics using existing tools. These concepts are discussed herein.

Recent Advances in Molecular, Multimodal and Theranostic Ultrasound Imaging

PubMed Central

Kiessling, Fabian; Fokong, Stanley; Bzyl, Jessica; Lederle, Wiltrud; Palmowski, Moritz; Lammers, Twan

2014-01-01

Ultrasound (US) imaging is an exquisite tool for the non-invasive and real-time diagnosis of many different diseases. In this context, US contrast agents can improve lesion delineation, characterization and therapy response evaluation. US contrast agents are usually micrometer-sized gas bubbles, stabilized with soft or hard shells. By conjugating antibodies to the microbubble (MB) surface, and by incorporating diagnostic agents, drugs or nucleic acids into or onto the MB shell, molecular, multimodal and theranostic MB can be generated. We here summarize recent advances in molecular, multimodal and theranostic US imaging, and introduce concepts how such advanced MB can be generated, applied and imaged. Examples are given for their use to image and treat oncological, cardiovascular and neurological diseases. Furthermore, we discuss for which therapeutic entities incorporation into (or conjugation to) MB is meaningful, and how US-mediated MB destruction can increase their extravasation, penetration, internalization and efficacy. PMID:24316070

Cross-cultural evidence for multimodal motherese: Asian Indian mothers' adaptive use of synchronous words and gestures.

PubMed

Gogate, Lakshmi; Maganti, Madhavilatha; Bahrick, Lorraine E

2015-01-01

In a quasi-experimental study, 24 Asian Indian mothers were asked to teach novel (target) names for two objects and two actions to their children of three different levels of lexical mapping development: prelexical (5-8 months), early lexical (9-17 months), and advanced lexical (20-43 months). Target naming (n=1482) and non-target naming (other, n=2411) were coded for synchronous spoken words and object motion (multimodal motherese) and other naming styles. Indian mothers abundantly used multimodal motherese with target words to highlight novel word-referent relations, paralleling earlier findings from American mothers. They used it with target words more often for prelexical infants than for advanced lexical children and to name target actions later in children's development. Unlike American mothers, Indian mothers also abundantly used multimodal motherese to name target objects later in children's development. Finally, monolingual mothers who spoke a verb-dominant Indian language used multimodal motherese more often than bilingual mothers who also spoke noun-dominant English to their children. The findings suggest that within a dynamic and reciprocal mother-infant communication system, multimodal motherese adapts to unify novel words and referents across cultures. It adapts to children's level of lexical development and to ambient language-specific lexical dominance hierarchies. Copyright © 2014 Elsevier Inc. All rights reserved.

Crucial breakthrough of second near-infrared biological window fluorophores: design and synthesis toward multimodal imaging and theranostics

DOE PAGES

He, Shuqing; Song, Jun; Qu, Junle; ...

2018-01-01

Recent advances in the chemical design and synthesis of fluorophores in the second near-infrared biological window (NIR-II) for multimodal imaging and theranostics are summarized and highlighted in this review article.

Crucial breakthrough of second near-infrared biological window fluorophores: design and synthesis toward multimodal imaging and theranostics

DOE Office of Scientific and Technical Information (OSTI.GOV)

He, Shuqing; Song, Jun; Qu, Junle

Recent advances in the chemical design and synthesis of fluorophores in the second near-infrared biological window (NIR-II) for multimodal imaging and theranostics are summarized and highlighted in this review article.

Advanced driver assistance systems: Using multimodal redundant warnings to enhance road safety.

PubMed

Biondi, Francesco; Strayer, David L; Rossi, Riccardo; Gastaldi, Massimiliano; Mulatti, Claudio

2017-01-01

This study investigated whether multimodal redundant warnings presented by advanced assistance systems reduce brake response times. Warnings presented by assistance systems are designed to assist drivers by informing them that evasive driving maneuvers are needed in order to avoid a potential accident. If these warnings are poorly designed, they may distract drivers, slow their responses, and reduce road safety. In two experiments, participants drove a simulated vehicle equipped with a forward collision avoidance system. Auditory, vibrotactile, and multimodal warnings were presented when the time to collision was shorter than five seconds. The effects of these warnings were investigated with participants performing a concurrent cell phone conversation (Exp. 1) or driving in high-density traffic (Exp. 2). Braking times and subjective workload were measured. Multimodal redundant warnings elicited faster braking reaction times. These warnings were found to be effective even when talking on a cell phone (Exp. 1) or driving in dense traffic (Exp. 2). Multimodal warnings produced higher ratings of urgency, but ratings of frustration did not increase compared to other warnings. Findings obtained in these two experiments are important given that faster braking responses may reduce the potential for a collision. Copyright © 2016 Elsevier Ltd. All rights reserved.

76 FR 32953 - Transportation Infrastructure/Multimodal Products and Services Trade Mission to Doha, Qatar, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-07

... new systems, particularly those related to multimodal freight and intelligent supply chain management... technologies, supply chain systems and strategies; mass transportation systems; advanced vehicle technologies... country. There are excellent opportunities for U.S. engineers, program management firms, and manufacturers...

Cross-Cultural Evidence for Multimodal Motherese: Asian-Indian Mothers’ Adaptive Use of Synchronous Words and Gestures

PubMed Central

Maganti, Madhavilatha; Bahrick, Lorraine E.

2014-01-01

In a quasi-experimental study, twenty-four Asian-Indian mothers were asked to teach novel (target) names for two objects and two actions to their children of three different levels of lexical-mapping development, pre-lexical (5–8 months), early-lexical (9–17 months), and advanced-lexical (20–43 months). Target (N = 1482) and non-target (other, N = 2411) naming was coded for synchronous spoken words and object motion (multimodal motherese) and other naming styles. Indian mothers abundantly used multimodal motherese with target words to highlight novel word-referent relations, paralleling earlier findings from American mothers (Gogate, Bahrick, & Watson, 2000). They used it with target words more often for pre-lexical infants than advanced-lexical children, and to name target actions later into children’s development. Unlike American mothers, Indian mothers also abundantly used multimodal motherese to name target objects later into children’s development. Finally, monolingual mothers who spoke a verb-dominant Indian language used multimodal motherese more often than bilingual mothers who also spoke noun-dominant English to their child. The findings suggest that within a dynamic and reciprocal mother-infant communication system, multimodal motherese adapts to unify novel words and referents across cultures. It adapts to children’s level of lexical development and to ambient language-specific lexical-dominance hierarchies. PMID:25285369

TDRSS multimode transponder program. Phase 2: Equipment development

NASA Technical Reports Server (NTRS)

Cnossen, R. S.

1974-01-01

This report contains a complete description of the TDRS Multimode Transponder and its associated ground support equipment. The transponder will demonstrate candidate modulation techniques to provide the required information for the design of an eventual VHF/UHF transponder suitable for installation in a user satellite, capable of operating as part of a Tracking and Data Relay Satellite (TDRS) systems. Use of geosynchronous TDRS which can serve both low data rate users at VHF and high data rate users at other frequencies has been considered. The effects of radio frequency interference from the earth and of multipath propagation due to reflections from the earth are expected to pose problems for the TDRS system at VHF. Investigations have suggested several modulation techniques that offer promise to overcome these problems.

Experimental study on the statistic characteristics of a 3x3 RF MIMO channel over a single conventional multimode fiber.

PubMed

Lei, Yi; Li, Jianqiang; Wu, Rui; Fan, Yuting; Fu, Songnian; Yin, Feifei; Dai, Yitang; Xu, Kun

2017-06-01

Based on the observed random fluctuation phenomenon of speckle pattern across multimode fiber (MMF) facet and received optical power distribution across three output ports, we experimentally investigate the statistic characteristics of a 3×3 radio frequency multiple-input multiple-output (MIMO) channel enabled by mode division multiplexing in a conventional 50 µm MMF using non-mode-selective three-dimensional waveguide photonic lanterns as mode multiplexer and demultiplexer. The impacts of mode coupling on the MIMO channel coefficients, channel matrix, and channel capacity have been analyzed over different fiber lengths. The results indicate that spatial multiplexing benefits from the greater fiber length with stronger mode coupling, despite a higher optical loss.

Challenges in Transcribing Multimodal Data: A Case Study

ERIC Educational Resources Information Center

Helm, Francesca; Dooly, Melinda

2017-01-01

Computer-mediated communication (CMC) once meant principally text-based communication mediated by computers, but rapid technological advances in recent years have heralded an era of multimodal communication with a growing emphasis on audio and video synchronous interaction. As CMC, in all its variants (text chats, video chats, forums, blogs, SMS,…

Utilizing Multi-Modal Literacies in Middle Grades Science

ERIC Educational Resources Information Center

Saurino, Dan; Ogletree, Tamra; Saurino, Penelope

2010-01-01

The nature of literacy is changing. Increased student use of computer-mediated, digital, and visual communication spans our understanding of adolescent multi-modal capabilities that reach beyond the traditional conventions of linear speech and written text in the science curriculum. Advancing technology opens doors to learning that involve…

Radiolabeled Nanoparticles for Multimodality Tumor Imaging

PubMed Central

Xing, Yan; Zhao, Jinhua; Conti, Peter S.; Chen, Kai

2014-01-01

Each imaging modality has its own unique strengths. Multimodality imaging, taking advantages of strengths from two or more imaging modalities, can provide overall structural, functional, and molecular information, offering the prospect of improved diagnostic and therapeutic monitoring abilities. The devices of molecular imaging with multimodality and multifunction are of great value for cancer diagnosis and treatment, and greatly accelerate the development of radionuclide-based multimodal molecular imaging. Radiolabeled nanoparticles bearing intrinsic properties have gained great interest in multimodality tumor imaging over the past decade. Significant breakthrough has been made toward the development of various radiolabeled nanoparticles, which can be used as novel cancer diagnostic tools in multimodality imaging systems. It is expected that quantitative multimodality imaging with multifunctional radiolabeled nanoparticles will afford accurate and precise assessment of biological signatures in cancer in a real-time manner and thus, pave the path towards personalized cancer medicine. This review addresses advantages and challenges in developing multimodality imaging probes by using different types of nanoparticles, and summarizes the recent advances in the applications of radiolabeled nanoparticles for multimodal imaging of tumor. The key issues involved in the translation of radiolabeled nanoparticles to the clinic are also discussed. PMID:24505237

GLOBECOM '89 - IEEE Global Telecommunications Conference and Exhibition, Dallas, TX, Nov. 27-30, 1989, Conference Record. Volumes 1, 2, & 3

NASA Astrophysics Data System (ADS)

The present conference discusses topics in multiwavelength network technology and its applications, advanced digital radio systems in their propagation environment, mobile radio communications, switching programmability, advancements in computer communications, integrated-network management and security, HDTV and image processing in communications, basic exchange communications radio advancements in digital switching, intelligent network evolution, speech coding for telecommunications, and multiple access communications. Also discussed are network designs for quality assurance, recent progress in coherent optical systems, digital radio applications, advanced communications technologies for mobile users, communication software for switching systems, AI and expert systems in network management, intelligent multiplexing nodes, video and image coding, network protocols and performance, system methods in quality and reliability, the design and simulation of lightwave systems, local radio networks, mobile satellite communications systems, fiber networks restoration, packet video networks, human interfaces for future networks, and lightwave networking.

Advanced functionality for radio analysis in the Offline software framework of the Pierre Auger Observatory

NASA Astrophysics Data System (ADS)

Abreu, P.; Aglietta, M.; Ahn, E. J.; Albuquerque, I. F. M.; Allard, D.; Allekotte, I.; Allen, J.; Allison, P.; Alvarez Castillo, J.; Alvarez-Muñiz, J.; Ambrosio, M.; Aminaei, A.; Anchordoqui, L.; Andringa, S.; Antičić, T.; Aramo, C.; Arganda, E.; Arqueros, F.; Asorey, H.; Assis, P.; Aublin, J.; Ave, M.; Avenier, M.; Avila, G.; Bäcker, T.; Balzer, M.; Barber, K. B.; Barbosa, A. F.; Bardenet, R.; Barroso, S. L. C.; Baughman, B.; Beatty, J. J.; Becker, B. R.; Becker, K. H.; Bellido, J. A.; Benzvi, S.; Berat, C.; Bertou, X.; Biermann, P. L.; Billoir, P.; Blanco, F.; Blanco, M.; Bleve, C.; Blümer, H.; Boháčová, M.; Boncioli, D.; Bonifazi, C.; Bonino, R.; Borodai, N.; Brack, J.; Brogueira, P.; Brown, W. C.; Bruijn, R.; Buchholz, P.; Bueno, A.; Burton, R. E.; Caballero-Mora, K. S.; Caramete, L.; Caruso, R.; Castellina, A.; Cataldi, G.; Cazon, L.; Cester, R.; Chauvin, J.; Chiavassa, A.; Chinellato, J. A.; Chou, A.; Chudoba, J.; Clay, R. W.; Coluccia, M. R.; Conceição, R.; Contreras, F.; Cook, H.; Cooper, M. J.; Coppens, J.; Cordier, A.; Cotti, U.; Coutu, S.; Covault, C. E.; Creusot, A.; Criss, A.; Cronin, J.; Curutiu, A.; Dagoret-Campagne, S.; Dallier, R.; Dasso, S.; Daumiller, K.; Dawson, B. R.; de Almeida, R. M.; de Domenico, M.; de Donato, C.; de Jong, S. J.; de La Vega, G.; de Mello Junior, W. J. M.; de Mello Neto, J. R. T.; de Mitri, I.; de Souza, V.; de Vries, K. D.; Decerprit, G.; Del Peral, L.; Deligny, O.; Dembinski, H.; Denkiewicz, A.; di Giulio, C.; Diaz, J. C.; Díaz Castro, M. L.; Diep, P. N.; Dobrigkeit, C.; D'Olivo, J. C.; Dong, P. N.; Dorofeev, A.; Dos Anjos, J. C.; Dova, M. T.; D'Urso, D.; Dutan, I.; Ebr, J.; Engel, R.; Erdmann, M.; Escobar, C. O.; Etchegoyen, A.; Facal San Luis, P.; Falcke, H.; Farrar, G.; Fauth, A. C.; Fazzini, N.; Ferguson, A. P.; Ferrero, A.; Fick, B.; Filevich, A.; Filipčič, A.; Fliescher, S.; Fracchiolla, C. E.; Fraenkel, E. D.; Fröhlich, U.; Fuchs, B.; Gamarra, R. F.; Gambetta, S.; García, B.; García Gámez, D.; Garcia-Pinto, D.; Gascon, A.; Gemmeke, H.; Gesterling, K.; Ghia, P. L.; Giaccari, U.; Giller, M.; Glass, H.; Gold, M. S.; Golup, G.; Gomez Albarracin, F.; Gómez Berisso, M.; Gonçalves, P.; Gonzalez, D.; Gonzalez, J. G.; Gookin, B.; Góra, D.; Gorgi, A.; Gouffon, P.; Gozzini, S. R.; Grashorn, E.; Grebe, S.; Griffith, N.; Grigat, M.; Grillo, A. F.; Guardincerri, Y.; Guarino, F.; Guedes, G. P.; Hague, J. D.; Hansen, P.; Harari, D.; Harmsma, S.; Harton, J. L.; Haungs, A.; Hebbeker, T.; Heck, D.; Herve, A. E.; Hojvat, C.; Holmes, V. C.; Homola, P.; Hörandel, J. R.; Horneffer, A.; Hrabovský, M.; Huege, T.; Insolia, A.; Ionita, F.; Italiano, A.; Jiraskova, S.; Kadija, K.; Kampert, K. H.; Karhan, P.; Karova, T.; Kasper, P.; Kégl, B.; Keilhauer, B.; Keivani, A.; Kelley, J. L.; Kemp, E.; Kieckhafer, R. M.; Klages, H. O.; Kleifges, M.; Kleinfeller, J.; Knapp, J.; Koang, D.-H.; Kotera, K.; Krohm, N.; Krömer, O.; Kruppke-Hansen, D.; Kuehn, F.; Kuempel, D.; Kulbartz, J. K.; Kunka, N.; La Rosa, G.; Lachaud, C.; Lautridou, P.; Leão, M. S. A. B.; Lebrun, D.; Lebrun, P.; Leigui de Oliveira, M. A.; Lemiere, A.; Letessier-Selvon, A.; Lhenry-Yvon, I.; Link, K.; López, R.; Lopez Agüera, A.; Louedec, K.; Lozano Bahilo, J.; Lucero, A.; Ludwig, M.; Lyberis, H.; Macolino, C.; Maldera, S.; Mandat, D.; Mantsch, P.; Mariazzi, A. G.; Marin, V.; Maris, I. C.; Marquez Falcon, H. R.; Marsella, G.; Martello, D.; Martin, L.; Martínez Bravo, O.; Mathes, H. J.; Matthews, J.; Matthews, J. A. J.; Matthiae, G.; Maurizio, D.; Mazur, P. O.; Medina-Tanco, G.; Melissas, M.; Melo, D.; Menichetti, E.; Menshikov, A.; Mertsch, P.; Meurer, C.; Mićanović, S.; Micheletti, M. I.; Miller, W.; Miramonti, L.; Mollerach, S.; Monasor, M.; Monnier Ragaigne, D.; Montanet, F.; Morales, B.; Morello, C.; Moreno, E.; Moreno, J. C.; Morris, C.; Mostafá, M.; Moura, C. A.; Mueller, S.; Muller, M. A.; Müller, G.; Münchmeyer, M.; Mussa, R.; Navarra, G.; Navarro, J. L.; Navas, S.; Necesal, P.; Nellen, L.; Nelles, A.; Nhung, P. T.; Nierstenhoefer, N.; Nitz, D.; Nosek, D.; Nožka, L.; Nyklicek, M.; Oehlschläger, J.; Olinto, A.; Oliva, P.; Olmos-Gilbaja, V. M.; Ortiz, M.; Pacheco, N.; Pakk Selmi-Dei, D.; Palatka, M.; Pallotta, J.; Palmieri, N.; Parente, G.; Parizot, E.; Parra, A.; Parrisius, J.; Parsons, R. D.; Pastor, S.; Paul, T.; Pech, M.; PeĶala, J.; Pelayo, R.; Pepe, I. M.; Perrone, L.; Pesce, R.; Petermann, E.; Petrera, S.; Petrinca, P.; Petrolini, A.; Petrov, Y.; Petrovic, J.; Pfendner, C.; Phan, N.; Piegaia, R.; Pierog, T.; Pieroni, P.; Pimenta, M.; Pirronello, V.; Platino, M.; Ponce, V. H.; Pontz, M.; Privitera, P.; Prouza, M.; Quel, E. J.; Rautenberg, J.; Ravel, O.; Ravignani, D.; Revenu, B.; Ridky, J.; Risse, M.; Ristori, P.; Rivera, H.; Riviére, C.; Rizi, V.; Robledo, C.; Rodrigues de Carvalho, W.; Rodriguez, G.; Rodriguez Martino, J.; Rodriguez Rojo, J.; Rodriguez-Cabo, I.; Rodríguez-Frías, M. D.; Ros, G.; Rosado, J.; Rossler, T.; Roth, M.; Rouillé-D'Orfeuil, B.; Roulet, E.; Rovero, A. C.; Rühle, C.; Salamida, F.; Salazar, H.; Salina, G.; Sánchez, F.; Santander, M.; Santo, C. E.; Santos, E.; Santos, E. M.; Sarazin, F.; Sarkar, S.; Sato, R.; Scharf, N.; Scherini, V.; Schieler, H.; Schiffer, P.; Schmidt, A.; Schmidt, F.; Schmidt, T.; Scholten, O.; Schoorlemmer, H.; Schovancova, J.; Schovánek, P.; Schroeder, F.; Schulte, S.; Schuster, D.; Sciutto, S. J.; Scuderi, M.; Segreto, A.; Semikoz, D.; Settimo, M.; Shadkam, A.; Shellard, R. C.; Sidelnik, I.; Sigl, G.; Śmiałkowski, A.; Šmída, R.; Snow, G. R.; Sommers, P.; Sorokin, J.; Spinka, H.; Squartini, R.; Stapleton, J.; Stasielak, J.; Stephan, M.; Stutz, A.; Suarez, F.; Suomijärvi, T.; Supanitsky, A. D.; Šuša, T.; Sutherland, M. S.; Swain, J.; Szadkowski, Z.; Szuba, M.; Tamashiro, A.; Tapia, A.; Taşcău, O.; Tcaciuc, R.; Tegolo, D.; Thao, N. T.; Thomas, D.; Tiffenberg, J.; Timmermans, C.; Tiwari, D. K.; Tkaczyk, W.; Todero Peixoto, C. J.; Tomé, B.; Tonachini, A.; Travnicek, P.; Tridapalli, D. B.; Tristram, G.; Trovato, E.; Tueros, M.; Ulrich, R.; Unger, M.; Urban, M.; Valdés Galicia, J. F.; Valiño, I.; Valore, L.; van den Berg, A. M.; Vargas Cárdenas, B.; Vázquez, J. R.; Vázquez, R. A.; Veberič, D.; Verzi, V.; Videla, M.; Villaseñor, L.; Wahlberg, H.; Wahrlich, P.; Wainberg, O.; Warner, D.; Watson, A. A.; Weber, M.; Weidenhaupt, K.; Weindl, A.; Westerhoff, S.; Whelan, B. J.; Wieczorek, G.; Wiencke, L.; Wilczyńska, B.; Wilczyński, H.; Will, M.; Williams, C.; Winchen, T.; Winders, L.; Winnick, M. G.; Wommer, M.; Wundheiler, B.; Yamamoto, T.; Younk, P.; Yuan, G.; Zamorano, B.; Zas, E.; Zavrtanik, D.; Zavrtanik, M.; Zaw, I.; Zepeda, A.; Ziolkowski, M.

2011-04-01

The advent of the Auger Engineering Radio Array (AERA) necessitates the development of a powerful framework for the analysis of radio measurements of cosmic ray air showers. As AERA performs “radio-hybrid” measurements of air shower radio emission in coincidence with the surface particle detectors and fluorescence telescopes of the Pierre Auger Observatory, the radio analysis functionality had to be incorporated in the existing hybrid analysis solutions for fluorescence and surface detector data. This goal has been achieved in a natural way by extending the existing Auger Offline software framework with radio functionality. In this article, we lay out the design, highlights and features of the radio extension implemented in the Auger Offline framework. Its functionality has achieved a high degree of sophistication and offers advanced features such as vectorial reconstruction of the electric field, advanced signal processing algorithms, a transparent and efficient handling of FFTs, a very detailed simulation of detector effects, and the read-in of multiple data formats including data from various radio simulation codes. The source code of this radio functionality can be made available to interested parties on request.

47 CFR 27.1250 - Transition of the 2150-2160/62 MHz band from the Broadband Radio Service to the Advanced Wireless...

Code of Federal Regulations, 2013 CFR

2013-10-01

... the Broadband Radio Service to the Advanced Wireless Service. 27.1250 Section 27.1250 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service Relocation Procedures for the...

47 CFR 27.1250 - Transition of the 2150-2160/62 MHz band from the Broadband Radio Service to the Advanced Wireless...

Code of Federal Regulations, 2012 CFR

2012-10-01

... the Broadband Radio Service to the Advanced Wireless Service. 27.1250 Section 27.1250 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service Relocation Procedures for the...

47 CFR 27.1250 - Transition of the 2150-2160/62 MHz band from the Broadband Radio Service to the Advanced Wireless...

Code of Federal Regulations, 2014 CFR

2014-10-01

... the Broadband Radio Service to the Advanced Wireless Service. 27.1250 Section 27.1250 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service Relocation Procedures for the...

Toward a Mobility-Driven Architecture for Multimodal Underwater Networking

DTIC Science & Technology

2017-02-01

applications. By equipping AUVs with short-range, high -bandwidth underwater wireless communications , which feature lower energy-per-bit cost than acoustic...protocols. They suffer from significant transmission path losses at high frequencies , long propagation delays, low and distance-dependent bandwidth, time...of data preprocessing, data compression, and either tethering to a surface buoy able to use radio frequency (RF) communications or using undersea

Spatial Structure of Multimode Oscillations in a Solar Flare on 14 May 2013 in EUV and Radio Bands

NASA Astrophysics Data System (ADS)

Kolotkov, Dmitry; Nakariakov, Valery; Nisticò, Giuseppe; Shibasaki, Kiyoto; Kupriyanova, Elena

Quasi-periodic pulsations and coronal loop oscillations in an X-class solar flare on 14 May 2013 are considered. Rapidly decaying kink oscillations of coronal loops with periods of several minutes in the flaring active region detected in the EUV band with SDO/AIA after the impulsive phase of the flare. Oscillations of neighbouring loops are excited simultaneously, but get rapidly out of phase. In the impulsive phase, observations in the radio band with the Nobeyama Radioheliograph and Radiopolarimeter show quasi-periodic pulsations that are most pronounced in the 17 GHz band. In the correlation plots and the integrated flux the pulsations have a symmetric triangular shape. The period of pulsations is about 1 min. Analysis of the spatial locations of the radio sources reveal that the triangularity is likely to be caused by superposition of several harmonic modes.

Design of a command, communications, and control van (surrogate)

NASA Astrophysics Data System (ADS)

Holder, J. Darryl; Fishback, Jerome

1989-03-01

This report describes the design, construction, and checkout of a radio and telephone multi-mode communications hub. This unit is to serve as a surrogate for a command, control, and communications van which is to be used in support of a special series of testing at a remote site. This unit is assembled in a military four-wheel van and has a crew of a commander and three operators. Radio communications monitoring can be performed in all popular modes of transmission from 50 KHz to 2 GHz and transmission can be performed on selected frequencies in the 40-meter, 6-meter, and 2-meter bands. Both voice and digital (teletype, packet, facsimile, etc.) communications are supported.

Advances in Radiotherapy Management of Esophageal Cancer.

PubMed

Verma, Vivek; Moreno, Amy C; Lin, Steven H

2016-10-21

Radiation therapy (RT) as part of multidisciplinary oncologic care has been marked by profound advancements over the past decades. As part of multimodality therapy for esophageal cancer (EC), a prime goal of RT is to minimize not only treatment toxicities, but also postoperative complications and hospitalizations. Herein, discussion commences with the historical approaches to treating EC, including seminal trials supporting multimodality therapy. Subsequently, the impact of RT techniques, including three-dimensional conformal RT, intensity-modulated RT, and proton beam therapy, is examined through available data. We further discuss existing data and the potential for further development in the future, with an appraisal of the future outlook of technological advancements of RT for EC.

Advances in Radiotherapy Management of Esophageal Cancer

PubMed Central

Verma, Vivek; Moreno, Amy C.; Lin, Steven H.

2016-01-01

Radiation therapy (RT) as part of multidisciplinary oncologic care has been marked by profound advancements over the past decades. As part of multimodality therapy for esophageal cancer (EC), a prime goal of RT is to minimize not only treatment toxicities, but also postoperative complications and hospitalizations. Herein, discussion commences with the historical approaches to treating EC, including seminal trials supporting multimodality therapy. Subsequently, the impact of RT techniques, including three-dimensional conformal RT, intensity-modulated RT, and proton beam therapy, is examined through available data. We further discuss existing data and the potential for further development in the future, with an appraisal of the future outlook of technological advancements of RT for EC. PMID:27775643

Computer-Based Multimodal Composing Activities, Self-Revision, and L2 Acquisition through Writing

ERIC Educational Resources Information Center

Dzekoe, Richmond

2017-01-01

This study investigated how 22 advanced-low proficiency ESL students used computer-based multimodal composing activities (CBMCAs) to facilitate self-revision and learn English through academic writing in the USA. The CBMCAs involved a combination of writing, listening, visual analysis, and speaking activities. The research was framed within an…

Contradictory Explorative Assessment. Multimodal Teacher/Student Interaction in Scandinavian Digital Learning Environments

ERIC Educational Resources Information Center

Kjällander, Susanne

2018-01-01

Assessment in the much-discussed digital divide in Scandinavian technologically advanced schools, is the study object of this article. Interaction is studied to understand assessment; and to see how assessment can be didactically designed to recognise students' learning. With a multimodal, design theoretical perspective on learning teachers' and…

Molecular brain imaging in the multimodality era

PubMed Central

Price, Julie C

2012-01-01

Multimodality molecular brain imaging encompasses in vivo visualization, evaluation, and measurement of cellular/molecular processes. Instrumentation and software developments over the past 30 years have fueled advancements in multimodality imaging platforms that enable acquisition of multiple complementary imaging outcomes by either combined sequential or simultaneous acquisition. This article provides a general overview of multimodality neuroimaging in the context of positron emission tomography as a molecular imaging tool and magnetic resonance imaging as a structural and functional imaging tool. Several image examples are provided and general challenges are discussed to exemplify complementary features of the modalities, as well as important strengths and weaknesses of combined assessments. Alzheimer's disease is highlighted, as this clinical area has been strongly impacted by multimodality neuroimaging findings that have improved understanding of the natural history of disease progression, early disease detection, and informed therapy evaluation. PMID:22434068

TDRS multimode transponder program. Phase 1: Design

NASA Technical Reports Server (NTRS)

Cnossen, R. S.

1972-01-01

The use of geosynchronous tracking and data relay satellites (TDRS) which can serve both low data rate users at VHF and high data rate users at other frequencies is considered. The effects of radio frequency interference from the earth and of multipath propagation due to reflections from the earth are expected to pose problems for the TDRS system at VHF. Investigations suggest several modulation techniques that offer promise to overcome these problems. This report provides a complete design of a VHF/UHF multimode transponder and its associated ground support equipment. The transponder is designed for installation aboard an aircraft and will demonstrate candidate modulation techniques to provide the required information for the design of an eventual VHF/UHF transponder suitable for installation in a user satellite, capable of operating as part of a TDRS system.

Fault-Tolerant Software-Defined Radio on Manycore

NASA Technical Reports Server (NTRS)

Ricketts, Scott

2015-01-01

Software-defined radio (SDR) platforms generally rely on field-programmable gate arrays (FPGAs) and digital signal processors (DSPs), but such architectures require significant software development. In addition, application demands for radiation mitigation and fault tolerance exacerbate programming challenges. MaXentric Technologies, LLC, has developed a manycore-based SDR technology that provides 100 times the throughput of conventional radiationhardened general purpose processors. Manycore systems (30-100 cores and beyond) have the potential to provide high processing performance at error rates that are equivalent to current space-deployed uniprocessor systems. MaXentric's innovation is a highly flexible radio, providing over-the-air reconfiguration; adaptability; and uninterrupted, real-time, multimode operation. The technology is also compliant with NASA's Space Telecommunications Radio System (STRS) architecture. In addition to its many uses within NASA communications, the SDR can also serve as a highly programmable research-stage prototyping device for new waveforms and other communications technologies. It can also support noncommunication codes on its multicore processor, collocated with the communications workload-reducing the size, weight, and power of the overall system by aggregating processing jobs to a single board computer.

Soldier-Robot Teaming: Effects of Multimodal Collaboration on Team Communication for Robot Reconnaissance

DTIC Science & Technology

2010-10-01

of the modes of communication and target types central to the experimental tasks, as well as a task demonstration. The Soldier then practiced the...experimental tasks with each communication modality on a separate training course with targets. Practice was structured such that a communication... practice structure across all three communication conditions. Radio was always introduced first, then chat, and lastly tactor. The exception to this

A simultaneous multimodal imaging system for tissue functional parameters

NASA Astrophysics Data System (ADS)

Ren, Wenqi; Zhang, Zhiwu; Wu, Qiang; Zhang, Shiwu; Xu, Ronald

2014-02-01

Simultaneous and quantitative assessment of skin functional characteristics in different modalities will facilitate diagnosis and therapy in many clinical applications such as wound healing. However, many existing clinical practices and multimodal imaging systems are subjective, qualitative, sequential for multimodal data collection, and need co-registration between different modalities. To overcome these limitations, we developed a multimodal imaging system for quantitative, non-invasive, and simultaneous imaging of cutaneous tissue oxygenation and blood perfusion parameters. The imaging system integrated multispectral and laser speckle imaging technologies into one experimental setup. A Labview interface was developed for equipment control, synchronization, and image acquisition. Advanced algorithms based on a wide gap second derivative reflectometry and laser speckle contrast analysis (LASCA) were developed for accurate reconstruction of tissue oxygenation and blood perfusion respectively. Quantitative calibration experiments and a new style of skinsimulating phantom were designed to verify the accuracy and reliability of the imaging system. The experimental results were compared with a Moor tissue oxygenation and perfusion monitor. For In vivo testing, a post-occlusion reactive hyperemia (PORH) procedure in human subject and an ongoing wound healing monitoring experiment using dorsal skinfold chamber models were conducted to validate the usability of our system for dynamic detection of oxygenation and perfusion parameters. In this study, we have not only setup an advanced multimodal imaging system for cutaneous tissue oxygenation and perfusion parameters but also elucidated its potential for wound healing assessment in clinical practice.

An optical mm-wave generation scheme by frequency octupling using a nested MMI

NASA Astrophysics Data System (ADS)

Shang, Lei; Wen, Aijun; Li, Bo; Wang, Tonggang; Chen, Yang; Li, Ming'an

2011-12-01

A novel method of a filterless optical millimeter-wave (MMW) signal generation with frequency octupling via a nested multimode interference (MMI) coupler is proposed for Radio-over-fiber systems. By setting the DC bias voltage applied to the central arms of MMI-b and MMI-c accurately, the optical carrier can be completely suppressed. The OSSR can be as high as about 58 dB without optical filter and the radio frequency spurious suppression ratio (RFSSR) exceeds 32 dB, which is the best result as we know. Simulation results suggest that when the generated optical mm-wave signal is transmitted along the standard single-mode fiber, the eye diagram is still opened after being transmitted over a 50 km fiber.

Ships/Trains/Planes/Automobiles: A Renaissance of their Interface

NASA Technical Reports Server (NTRS)

Allan, Stanley N.

1974-01-01

This paper highlights some of the major multi-modal interface problems created by technological advances, socio-political individualism and the flexibility of choices we expect from our transportation modes. The emphasis is on the need for a comprehensive national network of multi-modal priorities to enhance the movement of people and goods within the changing physical shape of our cities.

MSN anti-cancer nanomedicines: chemotherapy enhancement, overcoming of drug resistance, and metastasis inhibition.

PubMed

He, Qianjun; Shi, Jianlin

2014-01-22

In the anti-cancer war, there are three main obstacles resulting in high mortality and recurrence rate of cancers: the severe toxic side effect of anti-cancer drugs to normal tissues due to the lack of tumor-selectivity, the multi-drug resistance (MDR) to free chemotherapeutic drugs and the deadly metastases of cancer cells. The development of state-of-art nanomedicines based on mesoporous silica nanoparticles (MSNs) is expected to overcome the above three main obstacles. In the view of the fast development of anti-cancer strategy, this review highlights the most recent advances of MSN anti-cancer nanomedicines in enhancing chemotherapeutic efficacy, overcoming the MDR and inhibiting metastasis. Furthermore, we give an outlook of the future development of MSNs-based anti-cancer nanomedicines, and propose several innovative and forward-looking anti-cancer strategies, including tumor tissue-cell-nuclear successionally targeted drug delivery strategy, tumor cell-selective nuclear-targeted drug delivery strategy, multi-targeting and multi-drug strategy, chemo-/radio-/photodynamic-/ultrasound-/thermo-combined multi-modal therapy by virtue of functionalized hollow/rattle-structured MSNs. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Connection Analysis of Different Modes in Multimodal Transport

NASA Astrophysics Data System (ADS)

Zhao, Zhi; Lu, Ya Ya; Liu, Xing Hua; Jiang, Ying; Zhang, Yan Zhou

2018-06-01

As the most advanced way of transport organization, container multimodal transport provides high quality and efficient systematic logistics transportation services in a wide range of freight transport activities. So it has been widely promoted worldwide. China is in a period of sustained and rapid economic development, which needs greater support from logistics, while the rationalization of multimodal transport enables the best transport area of each transportation mode to be reflected. This paper makes an analysis of the connection between united transportation of railway and highway, rail and water transport and untied transportation of highway and water.

Angular and Polarization Response of Multimode Sensors with Resistive-Grid Absorbers

NASA Technical Reports Server (NTRS)

Kusaka, Akito; Wollack, Edward J.; Stevenson, Thomas R.

2014-01-01

High sensitivity receiver systems with near ideal polarization sensitivity are highly desirable for development of millimeter and sub-millimeter radio astronomy. Multimoded bolometers provide a unique solution to achieve such sensitivity, for which hundreds of single-mode sensors would otherwise be required. The primary concern in employing such multimoded sensors for polarimetery is the control of the polarization systematics. In this paper, we examine the angular- and polarization- dependent absorption pattern of a thin resistive grid or membrane, which models an absorber used for a multimoded bolometer. The result shows that a freestanding thin resistive absorber with a surface resistivity of eta/2, where eta is the impedance of free space, attains a beam pattern with equal E- and H-plane responses, leading to zero cross polarization. For a resistive-grid absorber, the condition is met when a pair of grids is positioned orthogonal to each other and both have a resistivity of eta/2. When a reflective backshort termination is employed to improve absorption efficiency, the cross-polar level can be suppressed below -30 dB if acceptance angle of the sensor is limited to < or approx. 60deg. The small cross-polar systematics have even-parity patterns and do not contaminate the measurements of odd-parity polarization patterns, for which many of recent instruments for cosmic microwave background are designed. Underlying symmetry that suppresses these cross-polar systematics is discussed in detail. The estimates and formalism provided in this paper offer key tools in the design consideration of the instruments using the multimoded polarimeters.

The Radio Amateur's Handbook.

ERIC Educational Resources Information Center

Blakeslee, Douglas, Ed.

The objectives of this basic reference work for the radio amateur are to present radio theory and practice in terms of application and to reflect both the fundamentals and the rapidly-advancing technology of radio communications so that the radio amateur will have a guide to what is practical, meaningful, proven, and useful. Twenty-three chapters…

The new frontiers of multimodality and multi-isotope imaging

NASA Astrophysics Data System (ADS)

Behnam Azad, Babak; Nimmagadda, Sridhar

2014-06-01

Technological advances in imaging systems and the development of target specific imaging tracers has been rapidly growing over the past two decades. Recent progress in "all-in-one" imaging systems that allow for automated image coregistration has significantly added to the growth of this field. These developments include ultra high resolution PET and SPECT scanners that can be integrated with CT or MR resulting in PET/CT, SPECT/CT, SPECT/PET and PET/MRI scanners for simultaneous high resolution high sensitivity anatomical and functional imaging. These technological developments have also resulted in drastic enhancements in image quality and acquisition time while eliminating cross compatibility issues between modalities. Furthermore, the most cutting edge technology, though mostly preclinical, also allows for simultaneous multimodality multi-isotope image acquisition and image reconstruction based on radioisotope decay characteristics. These scientific advances, in conjunction with the explosion in the development of highly specific multimodality molecular imaging agents, may aid in realizing simultaneous imaging of multiple biological processes and pave the way towards more efficient diagnosis and improved patient care.

Bayesian Inference on the Radio-quietness of Gamma-ray Pulsars

NASA Astrophysics Data System (ADS)

Yu, Hoi-Fung; Hui, Chung Yue; Kong, Albert K. H.; Takata, Jumpei

2018-04-01

For the first time we demonstrate using a robust Bayesian approach to analyze the populations of radio-quiet (RQ) and radio-loud (RL) gamma-ray pulsars. We quantify their differences and obtain their distributions of the radio-cone opening half-angle δ and the magnetic inclination angle α by Bayesian inference. In contrast to the conventional frequentist point estimations that might be non-representative when the distribution is highly skewed or multi-modal, which is often the case when data points are scarce, Bayesian statistics displays the complete posterior distribution that the uncertainties can be readily obtained regardless of the skewness and modality. We found that the spin period, the magnetic field strength at the light cylinder, the spin-down power, the gamma-ray-to-X-ray flux ratio, and the spectral curvature significance of the two groups of pulsars exhibit significant differences at the 99% level. Using Bayesian inference, we are able to infer the values and uncertainties of δ and α from the distribution of RQ and RL pulsars. We found that δ is between 10° and 35° and the distribution of α is skewed toward large values.

Radio Follow-Up of Gravitational-Wave Triggers during Advanced LIGO 01

DOE PAGES

Palliyaguru, N. T.; Corsi, Alessandra; Kasliwal, M. M.; ...

2016-09-28

We present radio follow-up observations carried out with the Karl G. Jansky Very Large Array during the first observing run (O1) of the Advanced Laser Interferometer Gravitational-wave Observatory (LIGO). A total of three gravitational-wave triggers were followed-up during the ≈4 months of O1, from 2015 September to 2016 January. Two of these triggers, GW150914 and GW151226, are binary black hole (BH) merger events of high significance. A third trigger, G194575, was subsequently declared as an event of no interest (i.e., a false alarm). Our observations targeted selected optical transients identified by the intermediate Palomar Transient Factory in the Advanced LIGOmore » error regions of the three triggers, and a limited region of the gravitational-wave localization area of G194575 not accessible to optical telescopes due to Sun constraints, where a possible high-energy transient was identified. No plausible radio counterparts to GW150914 and GW151226 were found, in agreement with expectations for binary BH mergers. We show that combining optical and radio observations is key to identifying contaminating radio sources that may be found in the follow-up of gravitational-wave triggers, such as emission associated with star formation and active galactic nuclei. We discuss our results in the context of the theoretical predictions for radio counterparts to gravitational-wave transients, and describe our future plans for the radio follow-up of Advanced LIGO (and Virgo) triggers.« less

Multimodal imaging of ischemic wounds

NASA Astrophysics Data System (ADS)

Zhang, Shiwu; Gnyawali, Surya; Huang, Jiwei; Liu, Peng; Gordillo, Gayle; Sen, Chandan K.; Xu, Ronald

2012-12-01

The wound healing process involves the reparative phases of inflammation, proliferation, and remodeling. Interrupting any of these phases may result in chronically unhealed wounds, amputation, or even patient death. Quantitative assessment of wound tissue ischemia, perfusion, and inflammation provides critical information for appropriate detection, staging, and treatment of chronic wounds. However, no method is available for noninvasive, simultaneous, and quantitative imaging of these tissue parameters. We integrated hyperspectral, laser speckle, and thermographic imaging modalities into a single setup for multimodal assessment of tissue oxygenation, perfusion, and inflammation characteristics. Advanced algorithms were developed for accurate reconstruction of wound oxygenation and appropriate co-registration between different imaging modalities. The multimodal wound imaging system was validated by an ongoing clinical trials approved by OSU IRB. In the clinical trial, a wound of 3mm in diameter was introduced on a healthy subject's lower extremity and the healing process was serially monitored by the multimodal imaging setup. Our experiments demonstrated the clinical usability of multimodal wound imaging.

The evolution of transmission security functions in modern military wideband radios

NASA Astrophysics Data System (ADS)

Matyszkiel, R.; Kaniewski, P.; Kustra, M.; Jach, J.

2017-04-01

Rapid development of advanced military command and control systems results in a dynamic growth in demand for data rate. One of the methods that make it possible to deal with the problem of limited capacity of military wireless systems is the use of broadband radios. Another one is the increase in the capacity of narrowband radios by implementing advanced modulation systems. Apart from remarkable benefits, such as the increase in system bit rate, there are also certain limitations since such radios are more sensitive to radio-electronic countermeasures, and the operation in the broad band makes it easier for the enemy to detect the radio emission. In such a situation, it is essential to define again and implement the transmission security functions into modern radios consistently. In this article, some current NATO activities are discussed, regarding the definitions of transmission security functions and the way of implementing them in radios, while paying special attention to a new element, that is to AIE radio cryptography (On Air Encryption). In the paper, the authors present an exemplary implementation of the functions in the Cognitive Radio Demonstrator using R-450C radio, the results of the examinations as well as the conclusions.

COSBID-M3: a platform for multimodal monitoring, data collection, and research in neurocritical care.

PubMed

Wilson, J Adam; Shutter, Lori A; Hartings, Jed A

2013-01-01

Neuromonitoring in patients with severe brain trauma and stroke is often limited to intracranial pressure (ICP); advanced neuroscience intensive care units may also monitor brain oxygenation (partial pressure of brain tissue oxygen, P(bt)O(2)), electroencephalogram (EEG), cerebral blood flow (CBF), or neurochemistry. For example, cortical spreading depolarizations (CSDs) recorded by electrocorticography (ECoG) are associated with delayed cerebral ischemia after subarachnoid hemorrhage and are an attractive target for novel therapeutic approaches. However, to better understand pathophysiologic relations and realize the potential of multimodal monitoring, a common platform for data collection and integration is needed. We have developed a multimodal system that integrates clinical, research, and imaging data into a single research and development (R&D) platform. Our system is adapted from the widely used BCI2000, a brain-computer interface tool which is written in the C++ language and supports over 20 data acquisition systems. It is optimized for real-time analysis of multimodal data using advanced time and frequency domain analyses and is extensible for research development using a combination of C++, MATLAB, and Python languages. Continuous streams of raw and processed data, including BP (blood pressure), ICP, PtiO2, CBF, ECoG, EEG, and patient video are stored in an open binary data format. Selected events identified in raw (e.g., ICP) or processed (e.g., CSD) measures are displayed graphically, can trigger alarms, or can be sent to researchers or clinicians via text message. For instance, algorithms for automated detection of CSD have been incorporated, and processed ECoG signals are projected onto three-dimensional (3D) brain models based on patient magnetic resonance imaging (MRI) and computed tomographic (CT) scans, allowing real-time correlation of pathoanatomy and cortical function. This platform will provide clinicians and researchers with an advanced tool to investigate pathophysiologic relationships and novel measures of cerebral status, as well as implement treatment algorithms based on such multimodal measures.

Multimodality Image Fusion-Guided Procedures: Technique, Accuracy, and Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abi-Jaoudeh, Nadine, E-mail: naj@mail.nih.gov; Kruecker, Jochen, E-mail: jochen.kruecker@philips.com; Kadoury, Samuel, E-mail: samuel.kadoury@polymtl.ca

2012-10-15

Personalized therapies play an increasingly critical role in cancer care: Image guidance with multimodality image fusion facilitates the targeting of specific tissue for tissue characterization and plays a role in drug discovery and optimization of tailored therapies. Positron-emission tomography (PET), magnetic resonance imaging (MRI), and contrast-enhanced computed tomography (CT) may offer additional information not otherwise available to the operator during minimally invasive image-guided procedures, such as biopsy and ablation. With use of multimodality image fusion for image-guided interventions, navigation with advanced modalities does not require the physical presence of the PET, MRI, or CT imaging system. Several commercially available methodsmore » of image-fusion and device navigation are reviewed along with an explanation of common tracking hardware and software. An overview of current clinical applications for multimodality navigation is provided.« less

Miniature EVA Software Defined Radio

NASA Technical Reports Server (NTRS)

Pozhidaev, Aleksey

2012-01-01

As NASA embarks upon developing the Next-Generation Extra Vehicular Activity (EVA) Radio for deep space exploration, the demands on EVA battery life will substantially increase. The number of modes and frequency bands required will continue to grow in order to enable efficient and complex multi-mode operations including communications, navigation, and tracking applications. Whether conducting astronaut excursions, communicating to soldiers, or first responders responding to emergency hazards, NASA has developed an innovative, affordable, miniaturized, power-efficient software defined radio that offers unprecedented power-efficient flexibility. This lightweight, programmable, S-band, multi-service, frequency- agile EVA software defined radio (SDR) supports data, telemetry, voice, and both standard and high-definition video. Features include a modular design, an easily scalable architecture, and the EVA SDR allows for both stationary and mobile battery powered handheld operations. Currently, the radio is equipped with an S-band RF section. However, its scalable architecture can accommodate multiple RF sections simultaneously to cover multiple frequency bands. The EVA SDR also supports multiple network protocols. It currently implements a Hybrid Mesh Network based on the 802.11s open standard protocol. The radio targets RF channel data rates up to 20 Mbps and can be equipped with a real-time operating system (RTOS) that can be switched off for power-aware applications. The EVA SDR's modular design permits implementation of the same hardware at all Network Nodes concept. This approach assures the portability of the same software into any radio in the system. It also brings several benefits to the entire system including reducing system maintenance, system complexity, and development cost.

Division x: Radio Astronomy

NASA Astrophysics Data System (ADS)

Taylor, Russ; Chapman, Jessica; Rendong, Nan; Carilli, Christopher; Giovannini, Gabriele; Hills, Richard; Hirabayashi, Hisashi; Jonas, Justin; Lazio, Joseph; Morganti, Raffaella; Rubio, Monica; Shastri, Prajval

2012-04-01

This triennium has seen a phenomenal investment in development of observational radio astronomy facilities in all parts of the globe at a scale that significantly impacts the international community. This includes both major enhancements such as the transition from the VLA to the EVLA in North America, and the development of new facilities such as LOFAR, ALMA, FAST, and Square Kilometre Array precursor telescopes in Australia and South Africa. These developments are driven by advances in radio-frequency, digital and information technologies that tremendously enhance the capabilities in radio astronomy. These new developments foreshadow major scientific advances driven by radio observations in the next triennium. We highlight these facility developments in section 3 of this report. A selection of science highlight from this triennium are summarized in section 2.

Human factors evaluation of the effectiveness of multi-modality displays in advanced traveler information systems

DOT National Transportation Integrated Search

1999-12-01

To achieve the goals for Advanced Traveler Information Systems (ATIS), significant information will necessarily be provided to the driver. A primary ATIS design issue is the display modality (i.e., visual, auditory, or the combination) selected for p...

MAESTRO: Methods and Advanced Equipment for Simulation and Treatment in Radio-Oncology

NASA Astrophysics Data System (ADS)

Barthe, Jean; Hugon, Régis; Nicolai, Jean Philippe

2007-12-01

The integrated project MAESTRO (Methods and Advanced Equipment for Simulation and Treatment in Radio-Oncology) under contract with the European Commission in life sciences FP6 (LSHC-CT-2004-503564), concerns innovative research to develop and validate in clinical conditions, advanced methods and equipment needed in cancer treatment for new modalities in high-conformal external radiotherapy using electrons, photons and protons beams of high energy.

Double plasma resonance instability as a source of solar zebra emission

NASA Astrophysics Data System (ADS)

Benáček, J.; Karlický, M.

2018-03-01

Context. The double plasma resonance (DPR) instability plays a basic role in the generation of solar radio zebras. In the plasma, consisting of the loss-cone type distribution of hot electrons and much denser and colder background plasma, this instability generates the upper-hybrid waves, which are then transformed into the electromagnetic waves and observed as radio zebras. Aims: In the present paper we numerically study the double plasma resonance instability from the point of view of the zebra interpretation. Methods: We use a 3-dimensional electromagnetic particle-in-cell (3D PIC) relativistic model. We use this model in two versions: (a) a spatially extended "multi-mode" model and (b) a spatially limited "specific-mode" model. While the multi-mode model is used for detailed computations and verifications of the results obtained by the "specific-mode" model, the specific-mode model is used for computations in a broad range of model parameters, which considerably save computational time. For an analysis of the computational results, we developed software tools in Python. Results: First using the multi-mode model, we study details of the double plasma resonance instability. We show how the distribution function of hot electrons changes during this instability. Then we show that there is a very good agreement between results obtained by the multi-mode and specific-mode models, which is caused by a dominance of the wave with the maximal growth rate. Therefore, for computations in a broad range of model parameters, we use the specific-mode model. We compute the maximal growth rates of the double plasma resonance instability with a dependence on the ratio between the upper-hybrid ωUH and electron-cyclotron ωce frequency. We vary temperatures of both the hot and background plasma components and study their effects on the resulting growth rates. The results are compared with the analytical ones. We find a very good agreement between numerical and analytical growth rates. We also compute saturation energies of the upper-hybrid waves in a very broad range of parameters. We find that the saturation energies of the upper-hybrid waves show maxima and minima at almost the same values of ωUH/ωce as the growth rates, but with a higher contrast between them than the growth rate maxima and minima. The contrast between saturation energy maxima and minima increases when the temperature of hot electrons increases. Furthermore, we find that the saturation energy of the upper-hybrid waves is proportional to the density of hot electrons. The maximum saturated energy can be up to one percent of the kinetic energy of hot electrons. Finally we find that the saturation energy maxima in the interval of ωUH/ωce = 3-18 decrease according to the exponential function. All these findings can be used in the interpretation of solar radio zebras.

User-oriented summary extraction for soccer video based on multimodal analysis

NASA Astrophysics Data System (ADS)

Liu, Huayong; Jiang, Shanshan; He, Tingting

2011-11-01

An advanced user-oriented summary extraction method for soccer video is proposed in this work. Firstly, an algorithm of user-oriented summary extraction for soccer video is introduced. A novel approach that integrates multimodal analysis, such as extraction and analysis of the stadium features, moving object features, audio features and text features is introduced. By these features the semantic of the soccer video and the highlight mode are obtained. Then we can find the highlight position and put them together by highlight degrees to obtain the video summary. The experimental results for sports video of world cup soccer games indicate that multimodal analysis is effective for soccer video browsing and retrieval.

Very large radio surveys of the sky

PubMed Central

Condon, J. J.

1999-01-01

Recent advances in electronics and computing have made possible a new generation of large radio surveys of the sky that yield an order-of-magnitude higher sensitivity and positional accuracy. Combined with the unique properties of the radio universe, these quantitative improvements open up qualitatively different and exciting new scientific applications of radio surveys. PMID:10220365

[A Case of Locally Advanced Thoracic Esophageal Cancer with Larynx Preservation and Curative Resection via Combined Modality Therapy].

PubMed

Iwama, Mitsuru; Kimura, Yutaka; Shiraishi, Osamu; Kato, Hiroaki; Hiraki, Yoko; Tanaka, Yumiko; Yasuda, Atsushi; Shinkai, Masayuki; Imano, Motohiro; Imamoto, Haruhiko; Yasuda, Takushi

2017-11-01

Prognosis of locally advanced esophageal cancer is poor. The greatest prognostic factor of locally advanced esophageal cancer is a local control. We experienced a case of T4 locally advanced thoracic esophageal cancer who was successfully resected without any combined resection after multimodality therapy. A male in 75-year-old. was diagnosed with type 3 locally advanced upper thoracic esophageal cancer whose metastatic right recurrent laryngeal lymph node invaded into the trachea. Definitive chemoradiation therapy(CRT)was performed, leading to a significant shrinkage of the main tumor, but T4 lesion remained. Next, adding DCF therapy(docetaxel, CDDP and 5-FU), a relief of T4 was finally obtained. Then, salvage surgery with subtotalesophagectomy and retrosternalesophagealreconstruction with gastric tube was performed, resulting in R0 resection without any combined resection. The postoperative course was uneventful, and the patient has been alive without recurrence for 1 year after surgery. In locally advanced cancer, focusing on T4 downstaging, it is significantly important in terms of safety, curativity and organ preservation to perform surgery after a sure sign of T4 relief by multimodality therapy.

Radionuclide Myocardial Perfusion Imaging for the Evaluation of Patients With Known or Suspected Coronary Artery Disease in the Era of Multimodality Cardiovascular Imaging

PubMed Central

Taqueti, Viviany R.; Di Carli, Marcelo F.

2018-01-01

Over the last several decades, radionuclide myocardial perfusion imaging (MPI) with single photon emission tomography and positron emission tomography has been a mainstay for the evaluation of patients with known or suspected coronary artery disease (CAD). More recently, technical advances in separate and complementary imaging modalities including coronary computed tomography angiography, computed tomography perfusion, cardiac magnetic resonance imaging, and contrast stress echocardiography have expanded the toolbox of diagnostic testing for cardiac patients. While the growth of available technologies has heralded an exciting era of multimodality cardiovascular imaging, coordinated and dispassionate utilization of these techniques is needed to implement the right test for the right patient at the right time, a promise of “precision medicine.” In this article, we review the maturing role of MPI in the current era of multimodality cardiovascular imaging, particularly in the context of recent advances in myocardial blood flow quantitation, and as applied to the evaluation of patients with known or suspected CAD. PMID:25770849

Experimental Array for Generating Dual Circularly-Polarized Dual-Mode OAM Radio Beams.

PubMed

Bai, Xu-Dong; Liang, Xian-Ling; Sun, Yun-Tao; Hu, Peng-Cheng; Yao, Yu; Wang, Kun; Geng, Jun-Ping; Jin, Rong-Hong

2017-01-10

Recently, vortex beam carrying orbital angular momentum (OAM) for radio communications has attracted much attention for its potential of transmitting multiple signals simultaneously at the same frequency, which can be used to increase the channel capacity. However, most of the methods for getting multi-mode OAM radio beams are of complicated structure and very high cost. This paper provides an effective solution of generating dual circularly-polarized (CP) dual-mode OAM beams. The antenna consists of four dual-CP elements which are sequentially rotated 90 degrees in the clockwise direction. Different from all previous published research relating to OAM generation by phased arrays, the four elements are fed with the same phase for both left-hand circular polarization (LHCP) and right-hand circular polarization (RHCP). The dual-mode operation for OAM is achieved through the opposite phase differences generated for LHCP and RHCP, when the dual-CP elements are sequentially rotated in the clockwise direction. The measured results coincide well with the simulated ones, which verified the effectiveness of the proposed design.

New medical workstation for multimodality communication systems

NASA Astrophysics Data System (ADS)

Kotsopoulos, Stavros A.; Lymberopoulos, Dimitris C.

1993-07-01

The introduction of special teleworking and advanced remote expert consultation procedures in the modern multimodality medical communication systems, has an effective result in the way of confronting synchronous and asynchronous patient cases, by the physicians. The common denominator in developing the above procedures is to use special designated Medical Workstations (MWS). The present paper deals with the implementation of a MWS which facilitates the doctors of medicine to handle efficiently multimedia data in an ISDN communication environment.

A new piezoelectric energy harvesting design concept: multimodal energy harvesting skin.

PubMed

Lee, Soobum; Youn, Byeng D

2011-03-01

This paper presents an advanced design concept for a piezoelectric energy harvesting (EH), referred to as multimodal EH skin. This EH design facilitates the use of multimodal vibration and enhances power harvesting efficiency. The multimodal EH skin is an extension of our previous work, EH skin, which was an innovative design paradigm for a piezoelectric energy harvester: a vibrating skin structure and an additional thin piezoelectric layer in one device. A computational (finite element) model of the multilayered assembly - the vibrating skin structure and piezoelectric layer - is constructed and the optimal topology and/or shape of the piezoelectric layer is found for maximum power generation from multiple vibration modes. A design rationale for the multimodal EH skin was proposed: designing a piezoelectric material distribution and external resistors. In the material design step, the piezoelectric material is segmented by inflection lines from multiple vibration modes of interests to minimize voltage cancellation. The inflection lines are detected using the voltage phase. In the external resistor design step, the resistor values are found for each segment to maximize power output. The presented design concept, which can be applied to any engineering system with multimodal harmonic-vibrating skins, was applied to two case studies: an aircraft skin and a power transformer panel. The excellent performance of multimodal EH skin was demonstrated, showing larger power generation than EH skin without segmentation or unimodal EH skin.

Navigation of Time-Coded Data

ERIC Educational Resources Information Center

Fouse, Adam S.

2013-01-01

Advances in technology now make it possible to capture detailed multimodal data about real-world everyday activity. Researchers have taken advantage of these advances to address questions about activity in more systematic and precise ways. Along with exciting opportunities to record data in ways that were not possible before, there are also…

Financial Statistics of CPB-Qualified Public Radio Stations: Fiscal Year 1970. Advance Edition.

ERIC Educational Resources Information Center

Pedone, Ronald J.; And Others

Based on information provided by public television and radio station licensees to the Corporation for Public Broadcasting (CPB), this report presents financial data for fiscal year 1970 for CPB-qualified public radio stations in the United States. A brief discussion of the 91 CPB-qualified public radio stations is provided first, along with an…

Advanced Technologies for Heterodyne Radio Astronomy Instrumentation - Part1 By A. Pavolotsky, and Advanced Technologies for Heterodyne Radio Astronomy Instrumentation - Part2 By V. Desmaris

NASA Astrophysics Data System (ADS)

Desmaris, Vincent

2018-01-01

We present the advanced micro/nano technological engineering at the atomic level producing state-of-the-art epitaxial NbN thin-films on GaN buffer layers. Furthermore, we report the outstanding performance of the hot electron bolometers fabricated on epitaxial NbN thin films on GaN buffer layers. Finally we present advanced passive devices such as waveguide hybrids, IF hybrids and combiners for the realization of heterodyne THz receivers.

Recurrent oral cavity cancer: Patterns of failure after salvage multimodality therapy.

PubMed

Quinlan-Davidson, Sean R; Morrison, William H; Myers, Jeffrey N; Gunn, Gary B; William, William N; Beadle, Beth M; Skinner, Heath D; Gillenwater, Ann M; Frank, Steven J; Phan, Jack; Johnson, Faye M; Fuller, Clifton D; Zafereo, Mark E; Rosenthal, David I; Garden, Adam S

2017-04-01

We focused on a cohort of radiation naïve patients who had recurrent oral cavity cancer (recurrent OCC) to assess their outcomes with salvage multimodal therapy. A retrospective single institutional study was performed of patients with recurrent OCC. Disease recurrence and survival outcomes were assessed. Seventy-eight patients were analyzed. All patients had salvage surgery and intensity-modulated radiotherapy (IMRT) and 74% had chemotherapy. Five-year overall survival, recurrence-free survival, and locoregional control rates were 59%, 60%, and 74%, respectively. Outcomes of radiation naïve patients with recurrent OCC are fair, and seem similar with patients with locally advanced nonrecurrent OCC treated with multimodal therapy. © 2016 Wiley Periodicals, Inc. Head Neck 39: 633-638, 2017. © 2016 Wiley Periodicals, Inc.

Radical Prostatectomy for Locally Advanced Prostate Cancers-Review of Literature.

PubMed

Srivatsa, N; Nagaraja, H; Shweta, S; Raghunath, S K

2017-06-01

Twenty-five to thirty percent of patients with prostate cancer present with locally advanced disease. While risk stratification remains the same with high incidence of upstaging of disease on imaging and histopathological evaluation; there have been progressive refinements in surgical therapy. With availability of reasonably robust data, radical prostatectomy in men with locally advanced prostate cancers seems to effect improvement in both cancer specific and overall survival rates in comparison to the current standard of care of radiation with androgen deprivation therapy. Studies using radical prostatectomy as a part of multimodality approach have also shown promising results. There is an imminent need for well-designed prospective studies of benefits of radical prostatectomy over radiation and androgen deprivation as well as benefits of multimodality therapy over monotherapy. Surgery for patients with locally advanced prostate cancer is technically challenging. Surgical outcomes are comparable to those of organ-confined disease when performed in high-volume centers. Neoadjuvant therapies prior to radical prostatectomy might improve surgical outcomes, but whether they will translate into a better cancer specific and overall survival are yet to be ascertained.

Phase-modulated radio over fiber multimode links.

PubMed

Gasulla, Ivana; Capmany, José

2012-05-21

We present the first experimental demonstration of a phase-modulated MMF link implementing high-frequency digital transmission in a cost-effective solution based on direct detection. Successful subcarrier transmission of QPSK, 16-QAM and 64-QAM data channels for bit rates up to 120 Mb/s through a 5 km MMF link is achieved over the microwave region comprised between 6 and 20 GHz. The overall capacity of the proposed approach can be further increased by properly accommodating more passband channels in the operative frequency range determined by the phase-to-intensity conversion process provided by the dispersive nature of the optical fiber. In this sense, our results show the possibility of achieving an aggregate bit rate per length product of 144 Gb/s · km and confirm, in consequence, the possibility of broadband phase-modulated radio over fiber transmission through MMF links suitable for multichannel SCM signal distribution.

Applications of surface acoustic and shallow bulk acoustic wave devices

NASA Astrophysics Data System (ADS)

Campbell, Colin K.

1989-10-01

Surface acoustic wave (SAW) device coverage includes delay lines and filters operating at selected frequencies in the range from about 10 MHz to 11 GHz; modeling with single-crystal piezoelectrics and layered structures; resonators and low-loss filters; comb filters and multiplexers; antenna duplexers; harmonic devices; chirp filters for pulse compression; coding with fixed and programmable transversal filters; Barker and quadraphase coding; adaptive filters; acoustic and acoustoelectric convolvers and correlators for radar, spread spectrum, and packet radio; acoustooptic processors for Bragg modulation and spectrum analysis; real-time Fourier-transform and cepstrum processors for radar and sonar; compressive receivers; Nyquist filters for microwave digital radio; clock-recovery filters for fiber communications; fixed-, tunable-, and multimode oscillators and frequency synthesizers; acoustic charge transport; and other SAW devices for signal processing on gallium arsenide. Shallow bulk acoustic wave device applications include gigahertz delay lines, surface-transverse-wave resonators employing energy-trapping gratings, and oscillators with enhanced performance and capability.

Chernobyl seed project. Advances in the identification of differentially abundant proteins in a radio-contaminated environment.

PubMed

Rashydov, Namik M; Hajduch, Martin

2015-01-01

Plants have the ability to grow and successfully reproduce in radio-contaminated environments, which has been highlighted by nuclear accidents at Chernobyl (1986) and Fukushima (2011). The main aim of this article is to summarize the advances of the Chernobyl seed project which has the purpose to provide proteomic characterization of plants grown in the Chernobyl area. We present a summary of comparative proteomic studies on soybean and flax seeds harvested from radio-contaminated Chernobyl areas during two successive generations. Using experimental design developed for radio-contaminated areas, altered abundances of glycine betaine, seed storage proteins, and proteins associated with carbon assimilation into fatty acids were detected. Similar studies in Fukushima radio-contaminated areas might complement these data. The results from these Chernobyl experiments can be viewed in a user-friendly format at a dedicated web-based database freely available at http://www.chernobylproteomics.sav.sk.

Chernobyl seed project. Advances in the identification of differentially abundant proteins in a radio-contaminated environment

PubMed Central

Rashydov, Namik M.; Hajduch, Martin

2015-01-01

Plants have the ability to grow and successfully reproduce in radio-contaminated environments, which has been highlighted by nuclear accidents at Chernobyl (1986) and Fukushima (2011). The main aim of this article is to summarize the advances of the Chernobyl seed project which has the purpose to provide proteomic characterization of plants grown in the Chernobyl area. We present a summary of comparative proteomic studies on soybean and flax seeds harvested from radio-contaminated Chernobyl areas during two successive generations. Using experimental design developed for radio-contaminated areas, altered abundances of glycine betaine, seed storage proteins, and proteins associated with carbon assimilation into fatty acids were detected. Similar studies in Fukushima radio-contaminated areas might complement these data. The results from these Chernobyl experiments can be viewed in a user-friendly format at a dedicated web-based database freely available at http://www.chernobylproteomics.sav.sk. PMID:26217350

USMC UGS technology advancements

NASA Astrophysics Data System (ADS)

Hartup, David C.; Barr, Michael E.; Hirz, Philip M.; Kipp, Jason; Fishburn, Thomas A.; Waller, Ezra S.; Marks, Brian A.

2008-04-01

Technology advancements for the USMC UGS system are described. Integration of the ARL Blue Radio/CSR into the System Controller and Radio Repeater permit the TRSS system to operate seamlessly within the Family of UGS concept. In addition to the Blue Radio/CSR, the TRSS system provides VHF and SATCOM radio links. The TRSS system is compatible with a wide range of imagers, including those with both analog and digital interfaces. The TRSS System Controller permits simultaneous monitoring of 2 camera inputs. To complement enhanced compatibility and improved processing, the mechanical housing of the TRSS System Controller has been updated. The SDR-II, a system monitoring device, also incorporates four Blue Radio/CSRs along with other communication capabilities, making it an ideal choice for a monitoring station within the Family of UGS. Field testing of L-3 Nova's UGS system at YPG has shown flawless performance, capturing all 126 targets.

Deep Space Telecommunications

NASA Technical Reports Server (NTRS)

Kuiper, T. B. H.; Resch, G. M.

2000-01-01

The increasing load on NASA's deep Space Network, the new capabilities for deep space missions inherent in a next-generation radio telescope, and the potential of new telescope technology for reducing construction and operation costs suggest a natural marriage between radio astronomy and deep space telecommunications in developing advanced radio telescope concepts.

Multimodality Imaging of Myocardial Injury and Remodeling

PubMed Central

Kramer, Christopher M.; Sinusas, Albert J.; Sosnovik, David E.; French, Brent A.; Bengel, Frank M.

2011-01-01

Advances in cardiovascular molecular imaging have come at a rapid pace over the last several years. Multiple approaches have been taken to better understand the structural, molecular, and cellular events that underlie the progression from myocardial injury to myocardial infarction (MI) and, ultimately, to congestive heart failure. Multimodality molecular imaging including SPECT, PET, cardiac MRI, and optical approaches is offering new insights into the pathophysiology of MI and left ventricular remodeling in small-animal models. Targets that are being probed include, among others, angiotensin receptors, matrix metalloproteinases, integrins, apoptosis, macrophages, and sympathetic innervation. It is only a matter of time before these advances are applied in the clinical setting to improve post-MI prognostication and identify appropriate therapies in patients to prevent the onset of congestive heart failure. PMID:20395347

Multi-Yield Radio Frequency Countermeasures Investigations and Development (MYRIAD) Task Order 006: Integrated Multi-Modal RF Sensing

DTIC Science & Technology

2012-08-01

wk1(n ) [ Prk k1(x k1(n ) )p(xk xk1(n ) )(x kspn Z1:k1)] n1 N  (220) A particle approximation of )( 11 :kk Zx is obtained using...221) where N is the number of particles for the new targets at time k, wk k1 (n )  Prk k1(x k1(n ) )wk1(n ) for  n 1,K N and wk k1 (n

Multimodal pain stimulation of the gastrointestinal tract

PubMed Central

Drewes, Asbjørn Mohr; Gregersen, Hans

2006-01-01

Understanding and characterization of pain and other sensory symptoms are among the most important issues in the diagnosis and assessment of patient with gastrointestinal disorders. Methods to evoke and assess experimental pain have recently developed into a new area with the possibility for multimodal stimulation (e.g., electrical, mechanical, thermal and chemical stimulation) of different nerves and pain pathways in the human gut. Such methods mimic to a high degree the pain experienced in the clinic. Multimodal pain methods have increased our basic understanding of different peripheral receptors in the gut in health and disease. Together with advanced muscle analysis, the methods have increased our understanding of receptors sensitive to mechanical, chemical and temperature stimuli in diseases, such as systemic sclerosis and diabetes. The methods can also be used to unravel central pain mechanisms, such as those involved in allodynia, hyperalgesia and referred pain. Abnormalities in central pain mechanisms are often seen in patients with chronic gut pain and hence methods relying on multimodal pain stimulation may help to understand the symptoms in these patients. Sex differences have been observed in several diseases of the gut, and differences in central pain processing between males and females have been hypothesized using multimodal pain stimulations. Finally, multimodal methods have recently been used to gain more insight into the effect of drugs against pain in the GI tract. Hence, the multimodal methods undoubtedly represents a major step forward in the future characterization and treatment of patients with various diseases of the gut. PMID:16688791

Study of the effects of multimodal exercise program on physical fitness and health perception in community-living Hungarian older adults.

PubMed

Virág, Anikó; Harkányi, Izabella; Karóczi, Csilla K; Vass, Zsolt; Kovács, Éva

2018-05-01

The aim of this study was to investigate the effects on fitness indicators and subjective health-perception of a multimodal exercise program provided by a district in Budapest among community-living seniors. Sixty community-living older adults aged over 60 years formed beginner group (who were at the beginning of the exercise program), advanced group (who had been in the programme for 3-6 months), active group (who had been participating in the exercise program for at least 6 months, in addition to Nordic walking program) and a physically inactive control group. Balance, functional mobility, lower and upper limb strength, lower and upper body flexibility, aerobic endurance and self-reported health perception were measured at baseline, and after a 12-week follow-up period. The beginner group and the advanced group improved in upper body flexibility (beginner Δ=1.2; d=0.83; advanced: Δ=1.7; d=1.39), lower body flexibility (beginner: Δ=1.7, d=0.484; advanced: Δ=1.9; d=1.55), lower limb strength (beginner: Δ=1.47; d=0.84; advanced: Δ=1.57; d=0.72), and functional mobility (beginner: Δ=-0.6; d=0.54; advanced: Δ=-0.4; d=0.90). There were also improvements in aerobic endurance (Δ=11.06; d=0.96) and balance (Δ=1.6; d=0.62) of beginner group. These indicators declined in the control group. Indicators of the active group did not change. The self-perceived health status declined (Δ=-13.9; d=0.73) in the control group but did not change in any exercising groups. This multimodal exercise program can be effective among community-living older adults, even in Hungary, a country where geriatric physical activity is not widespread. Therefore, it would be useful to extend this model program to other settlements as well.

Sensitivity-Bandwidth Limit in a Multimode Optoelectromechanical Transducer

NASA Astrophysics Data System (ADS)

Moaddel Haghighi, I.; Malossi, N.; Natali, R.; Di Giuseppe, G.; Vitali, D.

2018-03-01

An optoelectromechanical system formed by a nanomembrane capacitively coupled to an L C resonator and to an optical interferometer has recently been employed for the highly sensitive optical readout of rf signals [T. Bagci et al., Nature (London) 507, 81 (2013), 10.1038/nature13029]. We propose and experimentally demonstrate how the bandwidth of such a transducer can be increased by controlling the interference between two electromechanical interaction pathways of a two-mode mechanical system. With a proof-of-principle device operating at room temperature, we achieve a sensitivity of 300 nV /√{Hz } over a bandwidth of 15 kHz in the presence of radio-frequency noise, and an optimal shot-noise-limited sensitivity of 10 nV /√{Hz } over a bandwidth of 5 kHz. We discuss strategies for improving the performance of the device, showing that, for the same given sensitivity, a mechanical multimode transducer can achieve a bandwidth significantly larger than that for a single-mode one.

Advances in Induced Pluripotent Stem Cells, Genomics, Biomarkers, and Antiplatelet Therapy

PubMed Central

Barbato, Emanuele; Lara-Pezzi, Enrique; Stolen, Craig; Taylor, Angela; Barton, Paul J.; Bartunek, Jozef; Iaizzo, Paul; Judge, Daniel P.; Kirshenbaum, Lorrie; Blaxall, Burns C.; Terzic, Andre; Hall, Jennifer L.

2014-01-01

The Journal provides the clinician and scientist with the latest advances in discovery research, emerging technologies, pre-clinical research design and testing, and clinical trials. We highlight advances in areas of induced pluripotent stem cells, genomics, biomarkers, multi-modality imaging and antiplatelet biology and therapy. The top publications are critically discussed and presented along with anatomical reviews and FDA insight to provide context. PMID:24659088

Searching for Fast Radio Bursts with the Advanced Laser Interferometer Gravitational-wave Observatory (LIGO)

NASA Astrophysics Data System (ADS)

Fisher, Ryan Patrick; Hughey, Brennan; Howell, Eric; LIGO Collaboration

2018-01-01

Although Fast Radio Bursts (FRB) are being detected with increasing frequency, their progenitor systems are still mostly a mystery. We present the plan to conduct targeted searches for gravitational-wave counterparts to these FRB events in the data from the first and second observing runs of the Advanced Laser Interferometer Gravitational-wave Observatory (LIGO).

A multimodal interface for real-time soldier-robot teaming

NASA Astrophysics Data System (ADS)

Barber, Daniel J.; Howard, Thomas M.; Walter, Matthew R.

2016-05-01

Recent research and advances in robotics have led to the development of novel platforms leveraging new sensing capabilities for semantic navigation. As these systems becoming increasingly more robust, they support highly complex commands beyond direct teleoperation and waypoint finding facilitating a transition away from robots as tools to robots as teammates. Supporting future Soldier-Robot teaming requires communication capabilities on par with human-human teams for successful integration of robots. Therefore, as robots increase in functionality, it is equally important that the interface between the Soldier and robot advances as well. Multimodal communication (MMC) enables human-robot teaming through redundancy and levels of communications more robust than single mode interaction. Commercial-off-the-shelf (COTS) technologies released in recent years for smart-phones and gaming provide tools for the creation of portable interfaces incorporating MMC through the use of speech, gestures, and visual displays. However, for multimodal interfaces to be successfully used in the military domain, they must be able to classify speech, gestures, and process natural language in real-time with high accuracy. For the present study, a prototype multimodal interface supporting real-time interactions with an autonomous robot was developed. This device integrated COTS Automated Speech Recognition (ASR), a custom gesture recognition glove, and natural language understanding on a tablet. This paper presents performance results (e.g. response times, accuracy) of the integrated device when commanding an autonomous robot to perform reconnaissance and surveillance activities in an unknown outdoor environment.

Multidisciplinary, multimodal approach for a child with a traumatic facial scar.

PubMed

Admani, Shehla; Gertner, Jeffrey W; Grosman, Amanda; Shumaker, Peter R; Uebelhoer, Nathan S; Krakowski, Andrew C

2015-03-01

The treatment of disfiguring and disabling scars remains a field of active study, reinvigorated with recent advances in techniques and technologies. A variety of approaches can be utilized depending on scar characteristics, location, degree of tissue loss, and associated contractures. Just as traumatic scars can be complex and heterogeneous, the corresponding paradigm for treatment must also be flexible and multimodal for optimal improvement. This report describes a 3-year-old girl with a "mixed" (atrophic/hypertrophic), violaceous, contracted facial scar from a dog bite. It was treated with a novel approach utilizing a multidisciplinary pediatric scar team to combine autologous fat grafting, ablative fractional laser resurfacing, pulsed-dye laser, and laser-assisted delivery of a corticosteroid as concurrent, multimodal therapy to optimize the outcome. ©2015 Frontline Medical Communications.

Multimodal Nonlinear Optical Microscopy

PubMed Central

Yue, Shuhua; Slipchenko, Mikhail N.; Cheng, Ji-Xin

2013-01-01

Because each nonlinear optical (NLO) imaging modality is sensitive to specific molecules or structures, multimodal NLO imaging capitalizes the potential of NLO microscopy for studies of complex biological tissues. The coupling of multiphoton fluorescence, second harmonic generation, and coherent anti-Stokes Raman scattering (CARS) has allowed investigation of a broad range of biological questions concerning lipid metabolism, cancer development, cardiovascular disease, and skin biology. Moreover, recent research shows the great potential of using CARS microscope as a platform to develop more advanced NLO modalities such as electronic-resonance-enhanced four-wave mixing, stimulated Raman scattering, and pump-probe microscopy. This article reviews the various approaches developed for realization of multimodal NLO imaging as well as developments of new NLO modalities on a CARS microscope. Applications to various aspects of biological and biomedical research are discussed. PMID:24353747

Development of Radio Frequency Diesel Particulate Filter Sensor and Controls for Advanced Low Pressure Drop Systems to Reduce Engine Fuel Consumption (06B)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sappok, Alexander; Ragaller, Paul; Bromberg, Leslie

This project developed a radio frequencybased sensor for accurate measurement of diesel particulate filter (DPF) loading with advanced low pressuredrop aftertreatment systems. The resulting technology demonstrated engine efficiency improvements through optimization of the combined engineaftertreatment system while reducing emissions, system cost, and complexity to meet the DOE program objectives.

Waveform Developer's Guide for the Integrated Power, Avionics, and Software (iPAS) Space Telecommunications Radio System (STRS) Radio

NASA Technical Reports Server (NTRS)

Shalkhauser, Mary Jo W.; Roche, Rigoberto

2017-01-01

The Space Telecommunications Radio System (STRS) provides a common, consistent framework for software defined radios (SDRs) to abstract the application software from the radio platform hardware. The STRS standard aims to reduce the cost and risk of using complex, configurable and reprogrammable radio systems across NASA missions. To promote the use of the STRS architecture for future NASA advanced exploration missions, NASA Glenn Research Center (GRC) developed an STRS-compliant SDR on a radio platform used by the Advance Exploration System program at the Johnson Space Center (JSC) in their Integrated Power, Avionics, and Software (iPAS) laboratory. The iPAS STRS Radio was implemented on the Reconfigurable, Intelligently-Adaptive Communication System (RIACS) platform, currently being used for radio development at JSC. The platform consists of a Xilinx(Trademark) ML605 Virtex(Trademark)-6 FPGA board, an Analog Devices FMCOMMS1-EBZ RF transceiver board, and an Embedded PC (Axiomtek(Trademark) eBox 620-110-FL) running the Ubuntu 12.4 operating system. The result of this development is a very low cost STRS compliant platform that can be used for waveform developments for multiple applications. The purpose of this document is to describe how to develop a new waveform using the RIACS platform and the Very High Speed Integrated Circuits (VHSIC) Hardware Description Language (VHDL) FPGA wrapper code and the STRS implementation on the Axiomtek processor.

Radio-toxicity of spent fuel of the advanced heavy water reactor.

PubMed

Anand, S; Singh, K D S; Sharma, V K

2010-01-01

The Advanced Heavy Water Reactor (AHWR) is a new power reactor concept being developed at Bhabha Atomic Research Centre, Mumbai. The reactor retains many desirable features of the existing Pressurised Heavy Water Reactor (PHWR), while incorporating new, advanced safety features. The reactor aims to utilise the vast thorium resources available in India. The reactor core will use plutonium as the make-up fuel, while breeding (233)U in situ. On account of this unique combination of fuel materials, the operational characteristics of the fuel as determined by its radioactivity, decay heat and radio-toxicity are being viewed with great interest. Radio-toxicity of the spent fuel is a measure of potential radiological hazard to the members of the public and also important from the ecological point of view. The radio-toxicity of the AHWR fuel is extremely high to start with, being approximately 10(4) times that of the fresh natural U fuel used in a PHWR, and continues to remain relatively high during operation and subsequent cooling. A unique feature of this fuel is the peak observed in its radio-toxicity at approximately 10(5) y of decay cooling. The delayed increase in fuel toxicity has been traced primarily to a build-up of (229)Th, (230)Th and (226)Ra. This phenomenon has been observed earlier for thorium-based fuels and is confirmed for the AHWR fuel. This paper presents radio-toxicity data for AHWR spent fuel up to a period of 10(6) y and the results are compared with the radio-toxicity of PHWR.

Integrated Power, Avionics, and Software (iPAS) Space Telecommunications Radio System (STRS) Radio User's Guide -- Advanced Exploration Systems (AES)

NASA Technical Reports Server (NTRS)

Roche, Rigoberto; Shalkhauser, Mary Jo Windmille

2017-01-01

The Integrated Power, Avionics and Software (IPAS) software defined radio (SDR) was implemented on the Reconfigurable, Intelligently-Adaptive Communication System (RAICS) platform, for radio development at NASA Johnson Space Center. Software and hardware description language (HDL) code were delivered by NASA Glenn Research Center for use in the IPAS test bed and for development of their own Space Telecommunications Radio System (STRS) waveforms on the RAICS platform. The purpose of this document is to describe how to setup and operate the IPAS STRS Radio platform with its delivered test waveform.

Very low frequency (VLF) waves as diagnostic tool in remote sensing of D-region Ionosphere

NASA Astrophysics Data System (ADS)

Singh, Ashok; Verma, Uday Prakash

Large currents along the magnetic field transmit stresses between ionosphere and magnetosphere. If the electrons carrying such currents have high enough drift velocity, waves are generated. A wave is a disturbance that propagates through space and time, usually with transference of energy. Waves play major part in the Earth’s ionospheric dynamics. Since both the Earth and the ionosphere are good reflectors at very low frequencies (3 kHz 30 kHz), the lightning radiated impulses commonly known as radio atmospheric or sferics or tweeks travel thousands of kilometers in the Earth Ionosphere Wave Guide (EIWG) with low attenuation of ~ 2-3 dB/1000km. Since vlf waves are reflected by ionosphere, they can be used as potential tool to study the D-region ionosphere which plays a key role in the radio wave propagation. Since the year 2010, vlf waves are continuously being recorded at low latitude ground based Indian station Lucknow (Geomag. Lat. 17.60 N; Geomag. Long. 154.50 E) using Automatic Whistler Detector (AWD). More than 100 tweeks of multimode harmonics (n ≥ 3) observed during the year 2010-2011 are analyzed. Using these multimode tweeks as remote sensing tool to explore D-region ionosphere we have estimated various medium parameters such as electron density, ionospheric reflection height and the propagation distance etc. Electron density in the D-region ionosphere varies from 40-160 cm-3 for various modes, ionospheric reflection height varies in the range 70 - 85 km, and the propagation distance was found to vary from 2 km - 6 km in the waveguide to the receiving site.

Synthesis and radiolabeling of a somatostatin analog for multimodal imaging

NASA Astrophysics Data System (ADS)

Edwards, W. Barry; Liang, Kexian; Xu, Baogang; Anderson, Carolyn J.; Achilefu, Samuel

2006-02-01

A new multimodal imaging agent for imaging the somatostatin receptor has been synthesized and evaluated in vitro and in vivo. A somatostatin analog, conjugated to both 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraaceticacid (DOTA) and cypate (BS-296), was synthesized entirely on the solid phase (Fmoc) and purified by RP-HPLC. DOTA was added as a ligand for radiometals such as 64Cu or 177Lu for either radio-imaging or radiotherapy respectively. Cytate, a cypatesomatostatin analog conjugate, has previously demonstrated the ability to visualize somatostatin receptor rich tumor xenografts and natural organs by optical imaging techniques. BS-296 exhibited low nanomolar inhibitory capacity toward the binding of radiolabeled somatostatin analogs in cell membranes enriched in the somatostatin receptor, demonstrating the high affinity of this multimodal imaging peptide and indicating its potential as a molecular imaging agent. 64Cu, an isotope for diagnostic imaging and radiotherapy, was selected as the isotope for radiolabeling BS-296. BS-296 was radiolabeled with 64Cu in high specific activity (200 μCi/μg) in 90% radiochemical yield. Addition of 2,5-dihydroxybenzoic acid (gentisic acid) prevented radiolysis of the sample, allowing for study of the 64Cu -BS-296 the day following radiolabeling. Furthermore, inclusion of DMSO at a level of 20% was found not to interfere with radiolabeling yields and prevented the adherence of 64Cu -BS-296 to the walls of the reaction vessel.

Advanced Technologies For Heterodyne Radio Astronomy Instrumentation - Part1 By A. Pavolotsky, And Advanced Technologies For Heterodyne Radio Astronomy Instrumentation - Part2 By V. Desmaris

NASA Astrophysics Data System (ADS)

Pavolotsky, Alexey

2018-01-01

Modern and future heterodyne radio astronomy instrumentation critically depends on availability of advanced fabrication technologies and components. In Part1 of the Poster, we present the thin film fabrication process for SIS mixer receivers, utilizing either AlOx, or AlN barrier superconducting tunnel junctions developed and supported by GARD. The summary of the process design rules is presented. It is well known that performance of waveguide mixer components critically depends on accuracy of their geometrical dimensions. At GARD, all critical mechanical parts are 3D-mapped with a sub-um accuracy. Further progress of heterodyne instrumentation requires new efficient and compact sources of LO signal. We present SIS-based frequency multiplier, which could become a new option for LO source. Future radio astronomy THz receivers will need waveguide components, which fabricating due to their tiny dimensions is not feasible by traditional mechanical machining. We present the alternative micromachining technique for fabricating waveguide component for up 5 THz band and probably beyond.

The role of systemic therapy in the management of sinonasal cancer: A critical review.

PubMed

Bossi, Paolo; Saba, Nabil F; Vermorken, Jan B; Strojan, Primoz; Pala, Laura; de Bree, Remco; Rodrigo, Juan Pablo; Lopez, Fernando; Hanna, Ehab Y; Haigentz, Missak; Takes, Robert P; Slootweg, Piet J; Silver, Carl E; Rinaldo, Alessandra; Ferlito, Alfio

2015-12-01

Due to the rarity and the variety of histological types of sinonasal cancers, there is a paucity of data regarding strategy for their optimal treatment. Generally, outcomes of advanced and higher grade tumors remain unsatisfactory, despite the employment of sophisticated surgical approaches, technical advances in radiation techniques and the use of heavy ion particles. In this context, we critically evaluated the role of systemic therapy as part of a multidisciplinary approach to locally advanced disease. Induction chemotherapy has shown encouraging activity and could have a role in the multimodal treatment of patients with advanced sinonasal tumors. For epithelial tumors, the most frequently employed chemotherapy is cisplatin, in combination with either 5-fluorouracil, taxane, ifosfamide, or vincristine. Only limited experiences with concurrent chemoradiation exist with sinonasal cancer. The role of systemic treatment for each histological type (intestinal-type adenocarcinoma, sinonasal undifferentiated carcinoma, sinonasal neuroendocrine carcinoma, olfactory neuroblastoma, sinonasal primary mucosal melanoma, sarcoma) is discussed. The treatment of SNC requires a multimodal approach. Employment of systemic therapy for locally advanced disease could result in better outcomes, and optimize the therapeutic armamentarium. Further studies are needed to precisely define the role of systemic therapy and identify the optimal sequencing for its administration in relation to local therapies. Copyright © 2015 Elsevier Ltd. All rights reserved.

HamSCI: The Ham Radio Science Citizen Investigation

NASA Astrophysics Data System (ADS)

Frissell, N. A.; Moses, M. L.; Earle, G. D.; McGwier, R. W.; Miller, E. S.; Kaeppler, S. R.; Silver, H. W.; Ceglia, F.; Pascoe, D.; Sinanis, N.; Smith, P.; Williams, R.; Shovkoplyas, A.; Gerrard, A. J.

2016-12-01

Amateur (or "ham") radio operators are individuals with a non-pecuniary interest in radio technology, engineering, communications, science, and public service. They are licensed by their national governments to transmit on amateur radio frequencies. In many jurisdictions, there is no age requirement for a ham radio license, and operators from diverse backgrounds participate. There are more than 740,000 hams in the US, and over 3 million (estimated) worldwide. Many amateur communications are conducted using transionospheric links and thus affected by space weather and ionospheric processes. Recent technological advances have enabled the development of automated ham radio observation networks (e.g. the Reverse Beacon Network, www.reversebeacon.net) and specialized operating modes for the study of weak-signal propagation. The data from these networks have been shown to be useful for the study of ionospheric processes. In order to connect professional researchers with the volunteer-based ham radio community, HamSCI (Ham Radio Science Citizen Investigation, www.hamsci.org) has been established. HamSCI is a platform for publicizing and promoting projects that are consistent with the following objectives: (1) Advance scientific research and understanding through amateur radio activities. (2) Encourage the development of new technologies to support this research. (3) Provide educational opportunities for the amateur community and the general public. HamSCI researchers are working with the American Radio Relay League (ARRL, www.arrl.org) to publicize these objectives and recruit interested hams. The ARRL is the US national organization for amateur radio with a membership of over 170,000 and a monthly magazine, QST. HamSCI is currently preparing to support ionospheric research connected to the 21 Aug 2017 Total Solar Eclipse by expanding coverage of the Reverse Beacon Network and organizing a large-scale ham radio operating event ("QSO Party") to generate data during the eclipse.

Pulsed radio frequency energy in the treatment of complex diabetic foot wounds: two cases.

PubMed

Larsen, Jerrie A; Overstreet, Julia

2008-01-01

The use of radio waves (pulsed radio frequency energy) has become well accepted in the treatment of chronic wounds. We present 2 cases of complex diabetic foot wounds treated adjunctively with outpatient pulsed radio frequency energy using a solid-state, 27.12 MHz fixed power output radio frequency generator that transmits a fixed dose of nonionizing, nonthermal electromagnetic energy through an applicator pad. This therapy, in combination with offloading, debridement and advanced dressings, resulted in closure of both wounds in approximately 16 weeks.

Introduction of a standardized multimodality image protocol for navigation-guided surgery of suspected low-grade gliomas.

PubMed

Mert, Aygül; Kiesel, Barbara; Wöhrer, Adelheid; Martínez-Moreno, Mauricio; Minchev, Georgi; Furtner, Julia; Knosp, Engelbert; Wolfsberger, Stefan; Widhalm, Georg

2015-01-01

OBJECT Surgery of suspected low-grade gliomas (LGGs) poses a special challenge for neurosurgeons due to their diffusely infiltrative growth and histopathological heterogeneity. Consequently, neuronavigation with multimodality imaging data, such as structural and metabolic data, fiber tracking, and 3D brain visualization, has been proposed to optimize surgery. However, currently no standardized protocol has been established for multimodality imaging data in modern glioma surgery. The aim of this study was therefore to define a specific protocol for multimodality imaging and navigation for suspected LGG. METHODS Fifty-one patients who underwent surgery for a diffusely infiltrating glioma with nonsignificant contrast enhancement on MRI and available multimodality imaging data were included. In the first 40 patients with glioma, the authors retrospectively reviewed the imaging data, including structural MRI (contrast-enhanced T1-weighted, T2-weighted, and FLAIR sequences), metabolic images derived from PET, or MR spectroscopy chemical shift imaging, fiber tracking, and 3D brain surface/vessel visualization, to define standardized image settings and specific indications for each imaging modality. The feasibility and surgical relevance of this new protocol was subsequently prospectively investigated during surgery with the assistance of an advanced electromagnetic navigation system in the remaining 11 patients. Furthermore, specific surgical outcome parameters, including the extent of resection, histological analysis of the metabolic hotspot, presence of a new postoperative neurological deficit, and intraoperative accuracy of 3D brain visualization models, were assessed in each of these patients. RESULTS After reviewing these first 40 cases of glioma, the authors defined a specific protocol with standardized image settings and specific indications that allows for optimal and simultaneous visualization of structural and metabolic data, fiber tracking, and 3D brain visualization. This new protocol was feasible and was estimated to be surgically relevant during navigation-guided surgery in all 11 patients. According to the authors' predefined surgical outcome parameters, they observed a complete resection in all resectable gliomas (n = 5) by using contour visualization with T2-weighted or FLAIR images. Additionally, tumor tissue derived from the metabolic hotspot showed the presence of malignant tissue in all WHO Grade III or IV gliomas (n = 5). Moreover, no permanent postoperative neurological deficits occurred in any of these patients, and fiber tracking and/or intraoperative monitoring were applied during surgery in the vast majority of cases (n = 10). Furthermore, the authors found a significant intraoperative topographical correlation of 3D brain surface and vessel models with gyral anatomy and superficial vessels. Finally, real-time navigation with multimodality imaging data using the advanced electromagnetic navigation system was found to be useful for precise guidance to surgical targets, such as the tumor margin or the metabolic hotspot. CONCLUSIONS In this study, the authors defined a specific protocol for multimodality imaging data in suspected LGGs, and they propose the application of this new protocol for advanced navigation-guided procedures optimally in conjunction with continuous electromagnetic instrument tracking to optimize glioma surgery.

An Examination of Application of Artificial Neural Network in Cognitive Radios

NASA Astrophysics Data System (ADS)

Bello Salau, H.; Onwuka, E. N.; Aibinu, A. M.

2013-12-01

Recent advancement in software radio technology has led to the development of smart device known as cognitive radio. This type of radio fuses powerful techniques taken from artificial intelligence, game theory, wideband/multiple antenna techniques, information theory and statistical signal processing to create an outstanding dynamic behavior. This cognitive radio is utilized in achieving diverse set of applications such as spectrum sensing, radio parameter adaptation and signal classification. This paper contributes by reviewing different cognitive radio implementation that uses artificial intelligence such as the hidden markov models, metaheuristic algorithm and artificial neural networks (ANNs). Furthermore, different areas of application of ANNs and their performance metrics based approach are also examined.

Indianapolis Area ITS Early Deployment Plan Final Report

DOT National Transportation Integrated Search

1996-07-01

PUBLIC-PRIVATE PARTNERSHIP, TRAFFIC SIGNAL CONTROL, REGIONAL MULTIMODAL TRAVEL INFORMATION, ADVANCED RURAL TRANSPORTATION SYSTEMS OR ARTS : THIS DOCUMENT LAYS OUT A 20-YEAR SCHEDULE FOR THE IMPLEMENTATION OF ITS IN THE INDIANAPOLIS AREA. THE REPOR...

Impact of complete response to chemotherapy on overall survival in advanced colorectal cancer: results from Intergroup N9741.

PubMed

Dy, Grace K; Krook, James E; Green, Erin M; Sargent, Daniel J; Delaunoit, Thierry; Morton, Roscoe F; Fuchs, Charles S; Ramanathan, Ramesh K; Williamson, Stephen K; Findlay, Brian P; Pockaj, Barbara A; Sticca, Robert P; Alberts, Steven R; Pitot, Henry C; Goldberg, Richard M

2007-08-10

To evaluate clinical characteristics and survival outcomes among patients with locally advanced or metastatic colorectal cancer who achieve a complete response (CR) to systemic treatment either alone or with multimodality approach. Data were collected retrospectively from CRC patients enrolled onto the phase III trial N9741, a National Cancer Institute-funded and Gastrointestinal Cancer Intergroup-sponsored study coordinated by the North Central Cancer Treatment Group. Patients were randomly assigned to combinations of oxaliplatin, fluorouracil (FU)/leucovorin (LV) and irinotecan. The three treatment arms consist of IFL (irinotecan + FU/LV), FOLFOX4 (oxaliplatin + FU/LV), and IROX (irinotecan + oxaliplatin). Median follow-up was 42.6 months. Sixty-two (4%) of 1,508 patients had a CR to chemotherapy alone, and an additional 32 (2%) had a CR after multimodality treatment. Factors associated with achieving CR with systemic chemotherapy alone included FOLFOX4 treatment, patients with assessable disease, or a single site of metastasis. Continuing protocol treatment beyond two cycles after documentation of CR was not associated with improved survival. The rate of curative intent resection was significantly higher for patients treated with oxaliplatin-containing regimens (P = .02). Median survival was similar between patients with CR after chemotherapy alone (44.3 months) or after multimodality approach (47.4 months; P = .81). FOLFOX4 was more likely to produce a CR than were IFL or IROX. Oxaliplatin regimens were more likely to result in successful surgical resections. Patients who have CR to systemic chemotherapy alone can achieve impressive survival outcomes similar to those seen among patients who attained a CR status after multimodality treatment.

Sarcopenia: Prevalence, and Impact on Operative and Oncologic Outcomes in the Multimodal Management of Locally Advanced Esophageal Cancer.

PubMed

Elliott, Jessie A; Doyle, Suzanne L; Murphy, Conor F; King, Sinead; Guinan, Emer M; Beddy, Peter; Ravi, Narayanasamy; Reynolds, John V

2017-11-01

The aim of this article was to study the prevalence and significance of sarcopenia in the multimodal management of locally advanced esophageal cancer (LAEC), and to assess its independent impact on operative and oncologic outcomes. Sarcopenia in cancer may confer negative outcomes, but its prevalence and impact on modern multimodal regimens for LAEC have not been systematically studied. Two hundred fifty-two consecutive patients were studied. Lean body mass (LBM), skeletal muscle index (SMI), and fat mass (FM) were determined pre-treatment, preoperatively, and 1 year postoperatively. Sarcopenia was defined by computed tomography (CT) at L3 as SMI < 52.4 cm/m for males and SMI < 38.5 cm/m for females. All complications were recorded prospectively, including comprehensive complications index (CCI), Clavien-Dindo complication (CDC), and pulmonary complications (PPCs). Multivariable linear, logistic, and Cox regression analysis was performed. In-hospital mortality was 1%, and CCI was 21 ± 19. Sarcopenia increased (P = 0.02) from 16% at diagnosis to 31% post-neoadjuvant therapy, with loss of LBM (-3.0 ± 5.4 kg, P < 0.0001), but not FM (-0.3 ± 2.7 kg, P= 0.31) during treatment. On multivariable analysis, preoperative sarcopenia was associated with CCI (P = 0.043), and CDC ≥IIIb (P = 0.003). PPCs occurred in 36% nonsarcopenic versus 55% sarcopenic patients (P = 0.01). Sarcopenia did not impact disease-specific (P = 0.14) or overall survival (P = 0.11) after resection. At 1 year, 35% had sarcopenia, significantly associated with pre-treatment BMI (P = 0.013) but not complications (P = 0.20). Sarcopenia increases through multimodal therapy, is associated with an increased risk of major postoperative complications, and is prevalent in survivorship. These data highlight a potentially modifiable marker of risk that should be assessed and targeted in modern multimodal care pathways.

On the effects of multimodal information integration in multitasking.

PubMed

Stock, Ann-Kathrin; Gohil, Krutika; Huster, René J; Beste, Christian

2017-07-07

There have recently been considerable advances in our understanding of the neuronal mechanisms underlying multitasking, but the role of multimodal integration for this faculty has remained rather unclear. We examined this issue by comparing different modality combinations in a multitasking (stop-change) paradigm. In-depth neurophysiological analyses of event-related potentials (ERPs) were conducted to complement the obtained behavioral data. Specifically, we applied signal decomposition using second order blind identification (SOBI) to the multi-subject ERP data and source localization. We found that both general multimodal information integration and modality-specific aspects (potentially related to task difficulty) modulate behavioral performance and associated neurophysiological correlates. Simultaneous multimodal input generally increased early attentional processing of visual stimuli (i.e. P1 and N1 amplitudes) as well as measures of cognitive effort and conflict (i.e. central P3 amplitudes). Yet, tactile-visual input caused larger impairments in multitasking than audio-visual input. General aspects of multimodal information integration modulated the activity in the premotor cortex (BA 6) as well as different visual association areas concerned with the integration of visual information with input from other modalities (BA 19, BA 21, BA 37). On top of this, differences in the specific combination of modalities also affected performance and measures of conflict/effort originating in prefrontal regions (BA 6).

Hardware Interface Description for the Integrated Power, Avionics, and Software (iPAS) Space Telecommunications Radio Ssystem (STRS) Radio

NASA Technical Reports Server (NTRS)

Shalkhauser, Mary Jo W.; Roche, Rigoberto

2017-01-01

The Space Telecommunications Radio System (STRS) provides a common, consistent framework for software defined radios (SDRs) to abstract the application software from the radio platform hardware. The STRS standard aims to reduce the cost and risk of using complex, configurable and reprogrammable radio systems across NASA missions. To promote the use of the STRS architecture for future NASA advanced exploration missions, NASA Glenn Research Center (GRC) developed an STRS-compliant SDR on a radio platform used by the Advance Exploration System program at the Johnson Space Center (JSC) in their Integrated Power, Avionics, and Software (iPAS) laboratory. The iPAS STRS Radio was implemented on the Reconfigurable, Intelligently-Adaptive Communication System (RIACS) platform, currently being used for radio development at JSC. The platform consists of a Xilinx ML605 Virtex-6 FPGA board, an Analog Devices FMCOMMS1-EBZ RF transceiver board, and an Embedded PC (Axiomtek eBox 620-110-FL) running the Ubuntu 12.4 operating system. Figure 1 shows the RIACS platform hardware. The result of this development is a very low cost STRS compliant platform that can be used for waveform developments for multiple applications.The purpose of this document is to describe how to develop a new waveform using the RIACS platform and the Very High Speed Integrated Circuits (VHSIC) Hardware Description Language (VHDL) FPGA wrapper code and the STRS implementation on the Axiomtek processor.

Mechanical thrombolysis as an adjunct therapy to management of portal vein thrombosis following Radio Frequency Ablation.

PubMed

Hairol, A O; Affirul, C A; Azlanudin, A; Zamri, Z; Razman, J; Choi, S Y

2017-01-01

Radiofrequency ablation (RFA) has evolved to become the treatment of choice for non-resectable recurrent colorectal liver metastasis. It is however, not without complications. Portal vein thrombosis following RFA is rare but can be fatal to the outcome of the patient. Here, we present a case of a 66-year-old man who developed portal vein thrombosis following RFA. CT scan revealed a left portal vein thrombosis. This case report highlights the challenges and multimodal treatment of portal vein thrombosis following Radiofrequency ablation (RFA) in a cirrhotic patient.

Numerical study on simultaneous emission and transmission tomography in the MRI framework

NASA Astrophysics Data System (ADS)

Gjesteby, Lars; Cong, Wenxiang; Wang, Ge

2017-09-01

Multi-modality imaging methods are instrumental for advanced diagnosis and therapy. Specifically, a hybrid system that combines computed tomography (CT), nuclear imaging, and magnetic resonance imaging (MRI) will be a Holy Grail of medical imaging, delivering complementary structural/morphological, functional, and molecular information for precision medicine. A novel imaging method was recently demonstrated that takes advantage of radiotracer polarization to combine MRI principles with nuclear imaging. This approach allows the concentration of a polarized Υ-ray emitting radioisotope to be imaged with MRI resolution potentially outperforming the standard nuclear imaging mode at a sensitivity significantly higher than that of MRI. In our work, we propose to acquire MRI-modulated nuclear data for simultaneous image reconstruction of both emission and transmission parameters, suggesting the potential for simultaneous CT-SPECT-MRI. The synchronized diverse datasets allow excellent spatiotemporal registration and unique insight into physiological and pathological features. Here we describe the methodology involving the system design with emphasis on the formulation for tomographic images, even when significant radiotracer signals are limited to a region of interest (ROI). Initial numerical results demonstrate the feasibility of our approach for reconstructing concentration and attenuation images through a head phantom with various radio-labeled ROIs. Additional considerations regarding the radioisotope characteristics are also discussed.

Improved multimodal biomarkers for Alzheimer's disease and mild cognitive impairment diagnosis: data from ADNI

NASA Astrophysics Data System (ADS)

Martinez-Torteya, Antonio; Treviño-Alvarado, Víctor; Tamez-Peña, José

2013-02-01

The accurate diagnosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI) confers many clinical research and patient care benefits. Studies have shown that multimodal biomarkers provide better diagnosis accuracy of AD and MCI than unimodal biomarkers, but their construction has been based on traditional statistical approaches. The objective of this work was the creation of accurate AD and MCI diagnostic multimodal biomarkers using advanced bioinformatics tools. The biomarkers were created by exploring multimodal combinations of features using machine learning techniques. Data was obtained from the ADNI database. The baseline information (e.g. MRI analyses, PET analyses and laboratory essays) from AD, MCI and healthy control (HC) subjects with available diagnosis up to June 2012 was mined for case/controls candidates. The data mining yielded 47 HC, 83 MCI and 43 AD subjects for biomarker creation. Each subject was characterized by at least 980 ADNI features. A genetic algorithm feature selection strategy was used to obtain compact and accurate cross-validated nearest centroid biomarkers. The biomarkers achieved training classification accuracies of 0.983, 0.871 and 0.917 for HC vs. AD, HC vs. MCI and MCI vs. AD respectively. The constructed biomarkers were relatively compact: from 5 to 11 features. Those multimodal biomarkers included several widely accepted univariate biomarkers and novel image and biochemical features. Multimodal biomarkers constructed from previously and non-previously AD associated features showed improved diagnostic performance when compared to those based solely on previously AD associated features.

FFY 2007 annual report for the Montana Department of Transportation Research Programs

DOT National Transportation Integrated Search

2008-01-01

The Montana Department of Transportation (MDT) conducts research to discover, develop, or extend knowledge needed to operate, maintain, and improve the statewide multimodal transportation system. Specific goals include: evaluation and advancement of ...

A Technical Review of Cellular Radio and Analysis of a Possible Protocol

DTIC Science & Technology

1992-09-01

9 1. The Pioneers ............. ................................... 9 2. Time line of Radio Evolution...cellular telephone. Advances in low-power radio transmission and the speed with which modern computers can aid in frequency management and signal...lecturer at the Royal Institution in London. He subsequently worked his way up to lecturer and devoted ever increasing amounts of time to experiments

Exploring photoreceptor reflectivity via multimodal imaging of outer retinal tubulation in advanced age-related macular degeneration

PubMed Central

Litts, Katie M.; Wang, Xiaolin; Clark, Mark E.; Owsley, Cynthia; Freund, K. Bailey; Curcio, Christine A.; Zhang, Yuhua

2016-01-01

Purpose To investigate the microscopic structure of outer retinal tubulation (ORT) and optical properties of cone photoreceptors in vivo, we studied ORT appearance by multimodal imaging, including spectral domain optical coherence tomography (SD-OCT) and adaptive optics scanning laser ophthalmoscopy (AOSLO). Methods Four eyes of 4 subjects with advanced AMD underwent color fundus photography, infrared reflectance imaging, SD-OCT, and AOSLO with a high-resolution research instrument. ORT was identified in closely spaced (11 μm) SD-OCT volume scans. Results ORT in cross-sectional and en face SD-OCT was a hyporeflective area representing a lumen surrounded by a hyperreflective border consisting of cone photoreceptor mitochondria and external limiting membrane, per previous histology. In contrast, ORT by AOSLO was a hyporeflective structure of the same shape as in en face SD-OCT but lacking visualizable cone photoreceptors. Conclusion Lack of ORT cone reflectivity by AOSLO indicates that cones have lost their normal directionality and waveguiding property due to loss of outer segments and subsequent retinal remodeling. Reflective ORT cones by SD-OCT, in contrast, may depend partly on mitochondria as light scatterers within inner segments of these degenerating cells, a phenomenon enhanced by coherent imaging. Multimodal imaging of ORT provides insight into cone degeneration and reflectivity sources in OCT. PMID:27584549

Energy Logic (EL): a novel fusion engine of multi-modality multi-agent data/information fusion for intelligent surveillance systems

NASA Astrophysics Data System (ADS)

Rababaah, Haroun; Shirkhodaie, Amir

2009-04-01

The rapidly advancing hardware technology, smart sensors and sensor networks are advancing environment sensing. One major potential of this technology is Large-Scale Surveillance Systems (LS3) especially for, homeland security, battlefield intelligence, facility guarding and other civilian applications. The efficient and effective deployment of LS3 requires addressing number of aspects impacting the scalability of such systems. The scalability factors are related to: computation and memory utilization efficiency, communication bandwidth utilization, network topology (e.g., centralized, ad-hoc, hierarchical or hybrid), network communication protocol and data routing schemes; and local and global data/information fusion scheme for situational awareness. Although, many models have been proposed to address one aspect or another of these issues but, few have addressed the need for a multi-modality multi-agent data/information fusion that has characteristics satisfying the requirements of current and future intelligent sensors and sensor networks. In this paper, we have presented a novel scalable fusion engine for multi-modality multi-agent information fusion for LS3. The new fusion engine is based on a concept we call: Energy Logic. Experimental results of this work as compared to a Fuzzy logic model strongly supported the validity of the new model and inspired future directions for different levels of fusion and different applications.

Multimodal approaches for emotion recognition: a survey

NASA Astrophysics Data System (ADS)

Sebe, Nicu; Cohen, Ira; Gevers, Theo; Huang, Thomas S.

2004-12-01

Recent technological advances have enabled human users to interact with computers in ways previously unimaginable. Beyond the confines of the keyboard and mouse, new modalities for human-computer interaction such as voice, gesture, and force-feedback are emerging. Despite important advances, one necessary ingredient for natural interaction is still missing-emotions. Emotions play an important role in human-to-human communication and interaction, allowing people to express themselves beyond the verbal domain. The ability to understand human emotions is desirable for the computer in several applications. This paper explores new ways of human-computer interaction that enable the computer to be more aware of the user's emotional and attentional expressions. We present the basic research in the field and the recent advances into the emotion recognition from facial, voice, and physiological signals, where the different modalities are treated independently. We then describe the challenging problem of multimodal emotion recognition and we advocate the use of probabilistic graphical models when fusing the different modalities. We also discuss the difficult issues of obtaining reliable affective data, obtaining ground truth for emotion recognition, and the use of unlabeled data.

Multimodal approaches for emotion recognition: a survey

NASA Astrophysics Data System (ADS)

Sebe, Nicu; Cohen, Ira; Gevers, Theo; Huang, Thomas S.

2005-01-01

Recent technological advances have enabled human users to interact with computers in ways previously unimaginable. Beyond the confines of the keyboard and mouse, new modalities for human-computer interaction such as voice, gesture, and force-feedback are emerging. Despite important advances, one necessary ingredient for natural interaction is still missing-emotions. Emotions play an important role in human-to-human communication and interaction, allowing people to express themselves beyond the verbal domain. The ability to understand human emotions is desirable for the computer in several applications. This paper explores new ways of human-computer interaction that enable the computer to be more aware of the user's emotional and attentional expressions. We present the basic research in the field and the recent advances into the emotion recognition from facial, voice, and physiological signals, where the different modalities are treated independently. We then describe the challenging problem of multimodal emotion recognition and we advocate the use of probabilistic graphical models when fusing the different modalities. We also discuss the difficult issues of obtaining reliable affective data, obtaining ground truth for emotion recognition, and the use of unlabeled data.

Magnetospheric radio and plasma wave research - 1987-1990

NASA Technical Reports Server (NTRS)

Kurth, W. S.

1991-01-01

This review covers research performed in the area of magnetospheric plasma waves and wave-particle interactions as well as magnetospheric radio emissions. The report focuses on the near-completion of the discovery phase of radio and plasma wave phenomena in the planetary magnetospheres with the successful completion of the Voyager 2 encounters of Neptune and Uranus. Consideration is given to the advances made in detailed studies and theoretical investigations of radio and plasma wave phenomena in the terrestrial magnetosphere or in magnetospheric plasmas in general.

Big data sharing and analysis to advance research in post-traumatic epilepsy.

PubMed

Duncan, Dominique; Vespa, Paul; Pitkanen, Asla; Braimah, Adebayo; Lapinlampi, Nina; Toga, Arthur W

2018-06-01

We describe the infrastructure and functionality for a centralized preclinical and clinical data repository and analytic platform to support importing heterogeneous multi-modal data, automatically and manually linking data across modalities and sites, and searching content. We have developed and applied innovative image and electrophysiology processing methods to identify candidate biomarkers from MRI, EEG, and multi-modal data. Based on heterogeneous biomarkers, we present novel analytic tools designed to study epileptogenesis in animal model and human with the goal of tracking the probability of developing epilepsy over time. Copyright © 2017. Published by Elsevier Inc.

Multimodal nanoparticle imaging agents: design and applications

NASA Astrophysics Data System (ADS)

Burke, Benjamin P.; Cawthorne, Christopher; Archibald, Stephen J.

2017-10-01

Molecular imaging, where the location of molecules or nanoscale constructs can be tracked in the body to report on disease or biochemical processes, is rapidly expanding to include combined modality or multimodal imaging. No single imaging technique can offer the optimum combination of properties (e.g. resolution, sensitivity, cost, availability). The rapid technological advances in hardware to scan patients, and software to process and fuse images, are pushing the boundaries of novel medical imaging approaches, and hand-in-hand with this is the requirement for advanced and specific multimodal imaging agents. These agents can be detected using a selection from radioisotope, magnetic resonance and optical imaging, among others. Nanoparticles offer great scope in this area as they lend themselves, via facile modification procedures, to act as multifunctional constructs. They have relevance as therapeutics and drug delivery agents that can be tracked by molecular imaging techniques with the particular development of applications in optically guided surgery and as radiosensitizers. There has been a huge amount of research work to produce nanoconstructs for imaging, and the parameters for successful clinical translation and validation of therapeutic applications are now becoming much better understood. It is an exciting time of progress for these agents as their potential is closer to being realized with translation into the clinic. The coming 5-10 years will be critical, as we will see if the predicted improvement in clinical outcomes becomes a reality. Some of the latest advances in combination modality agents are selected and the progression pathway to clinical trials analysed. This article is part of the themed issue 'Challenges for chemistry in molecular imaging'.

The Evolution of Technology in the Deep Space Network: A History of the Advanced Systems Program

NASA Technical Reports Server (NTRS)

Layland, J. W.; Rauch, L. L.

1994-01-01

The Deep Space Network (DSN) of 1995 might be described as the evolutionary result of 45 years of deep space communication and navigation, together with the synergistic activities of radio science and radar and radio astronomy. But the evolution of the DSN did not just happen - it was carefully planned and created. The evolution of the DSN has been an ongoing engineering activity, and engineering is a process of problem solving under constraints, one of which is technology. In turn, technology is the knowledge base providing the capability and experience for practical application of various areas of science, when needed. The best engineering solutions result from optimization under the fewest constraints, and if technology needs are well anticipated (ready when needed), then the most effective engineering solution is possible. Throughout the history of the DSN it has been the goal and function of DSN advanced technology development (designated the DSN Advanced Systems Program from 1963 through 1994) to supply the technology needs of the DSN when needed, and thus to minimize this constraint on DSN engineering. Technology often takes considerable time to develop, and when that happens, it is important to have anticipated engineering needs; at times, this anticipation has been by as much as 15 years. Also, on a number of occasions, mission malfunctions or emergencies have resulted in unplanned needs for technology that has, in fact, been available from the reservoir of advanced technology provided by the DSN Advanced Systems Program. Sometimes, even DSN engineering personnel fail to realize that the organization of JPL permits an overlap of DSN advanced technology activities with subsequent engineering activities. This can result in the flow of advanced technology into DSN engineering in a natural and sometimes almost unnoticed way. In the following pages, we will explore some of the many contributions of the DSN Advanced Systems Program that were provided to DSN Engineering and Implementation. These contributions are, for the most part, unique capabilities that have met the requirements of flight projects for 45 years. These unique capabilities include not only the world's best deep-space communications system, but also outstanding competency in the fields of radio metric measurement, radar and radio astronomy, and radio science.

Advanced Public Transportation Systems (Apts) Project Summaries, June 1996, Office Of Mobility

DOT National Transportation Integrated Search

1996-06-01

ITS APPLIES STATE-OF-THE-ART AND EMERGING TECHNOLOGIES TO PROVIDE MORE EFFICIENT AND EFFECTIVE SOLUTIONS TO CURRENT MULTIMODAL TRANSPORTATION PROBLEMS, AS WELL AS ANTICIPATE AND ADDRESS FUTURE TRANSPORTATION DEMANDS THROUGH AN INTERMODAL, STRATEGIC A...

[Utilization of multimodal therapy concepts in stomach carcinoma in Germany].

PubMed

Bösing, N M; Heise, J W; Röher, H D

2000-01-01

In view of disappointing results after surgery alone multimodal therapeutic regimes are used to improve long-term prognosis in locally advanced gastric carcinomas. In presence of many reports about encouraging results ("down staging", improved R0-resection rates) but simultaneously missing evidence of efficiency of neoadjuvant therapies in respect to long-term survival (large randomized multicenter trials do not exist until today) and the herewith related uncertainties, we started an inquiry among many surgical units with the intention to evaluate the clinical practice of multimodal treatment for gastric cancer patients in Germany today. In a questionnaire (3/99) we asked among 97 surgical units (41 university hospitals, 56 big community hospitals) in Germany for the management of gastric cancer patients with special interest to practice and state of adjuvant and neoadjuvant therapeutic strategies. Further we analyzed all resected gastric cancer patients (1986-1995) without neoadjuvant treatment in advanced stage of disease (pT3/4NxMx; stage III/IV (UICC'92) in respect to R0-resection rate and long-term prognosis (Kaplan-Meier). Overall feedback amounted to 78% (76/97) and was higher in university hospitals (90%) than in big community hospitals (70%). Today, neoadjuvant therapies are of more interest than adjuvant therapeutic regimes. But also neoadjuvant therapy is only used in 32% as a rule (in 16% with, in 16% without study conditions). 25% of all surgical units do not employ any neoadjuvant therapy in locally advanced gastric cancer until today. In all other surgical units neoadjuvant treatment is performed more individually and sporadically (43%) only in some patients. Neoadjuvant therapies are practiced by haematooncologists in 50%, gastroenterologists in 32% and surgeons in 27%. The predominant neoadjuvant therapeutic strategy is chemotherapy alone (84%). Many surgical units in Germany are interested to participate in a multicenter trial with more interest in neoadjuvant than adjuvant therapy. 185 of 309 resected gastric cancer patients (60%) were classified as stage IIIa, stage IIIb or stage IV patients. R0-resection rate of these advanced gastric cancer patients amounted to 37%; only 24% of them survived 5 years or more. Considering the missing evidence that multimodal therapies are able to prolong long-term survival in advanced gastric cancer patients, its use without study conditions is questionable. Conclusions, taken from data of clinical trials regarding carcinomas of the esophagus and esophagealgastric junction, are inconsistent in respect to long-term prognosis and results are not transferable to gastric carcinomas. A prospective randomized multicenter trial in advanced gastric cancer patients is of great importance. Following our data, in Germany a high readiness to participate in the forthcoming EORTC-study is present.

Programmable Logic Device (PLD) Design Description for the Integrated Power, Avionics, and Software (iPAS) Space Telecommunications Radio System (STRS) Radio

NASA Technical Reports Server (NTRS)

Shalkhauser, Mary Jo W.

2017-01-01

The Space Telecommunications Radio System (STRS) provides a common, consistent framework for software defined radios (SDRs) to abstract the application software from the radio platform hardware. The STRS standard aims to reduce the cost and risk of using complex, configurable and reprogrammable radio systems across NASA missions. To promote the use of the STRS architecture for future NASA advanced exploration missions, NASA Glenn Research Center (GRC) developed an STRS compliant SDR on a radio platform used by the Advance Exploration System program at the Johnson Space Center (JSC) in their Integrated Power, Avionics, and Software (iPAS) laboratory. At the conclusion of the development, the software and hardware description language (HDL) code was delivered to JSC for their use in their iPAS test bed to get hands-on experience with the STRS standard, and for development of their own STRS Waveforms on the now STRS compliant platform.The iPAS STRS Radio was implemented on the Reconfigurable, Intelligently-Adaptive Communication System (RIACS) platform, currently being used for radio development at JSC. The platform consists of a Xilinx ML605 Virtex-6 FPGA board, an Analog Devices FMCOMMS1-EBZ RF transceiver board, and an Embedded PC (Axiomtek eBox 620-110-FL) running the Ubuntu 12.4 operating system. Figure 1 shows the RIACS platform hardware. The result of this development is a very low cost STRS compliant platform that can be used for waveform developments for multiple applications.The purpose of this document is to describe the design of the HDL code for the FPGA portion of the iPAS STRS Radio particularly the design of the FPGA wrapper and the test waveform.

High-aggregate-capacity visible light communication links using stacked multimode polymer waveguides and micro-pixelated LED arrays

NASA Astrophysics Data System (ADS)

Bamiedakis, N.; McKendry, J. J. D.; Xie, E.; Gu, E.; Dawson, M. D.; Penty, R. V.; White, I. H.

2018-02-01

In recent years, light emitting diodes (LEDs) have gained renewed interest for use in visible light communication links (VLC) owing to their potential use as both high-quality power-efficient illumination sources as well as low-cost optical transmitters in free-space and guided-wave links. Applications that can benefit from their use include optical wireless systems (LiFi and Internet of Things), in-home and automotive networks, optical USBs and short-reach low-cost optical interconnects. However, VLC links suffer from the limited LED bandwidth (typically 100 MHz). As a result, a combination of novel LED devices, advanced modulation formats and multiplexing methods are employed to overcome this limitation and achieve high-speed (>1 Gb/s) data transmission over such links. In this work, we present recent advances in the formation of high-aggregate-capacity low cost guided wave VLC links using stacked polymer multimode waveguides and matching micro-pixelated LED (μLED) arrays. μLEDs have been shown to exhibit larger bandwidths (>200 MHz) than conventional broad-area LEDs and can be formed in large array configurations, while multimode polymer waveguides enable the formation of low-cost optical links onto standard PCBs. Here, three- and four-layered stacks of multimode waveguides, as well as matching GaN μLED arrays, are fabricated in order to generate high-density yet low-cost optical interconnects. Different waveguide topologies are implemented and are investigated in terms of loss and crosstalk performance. The initial results presented herein demonstrate good intrinsic crosstalk performance and indicate the potential to achieve >= 0.5 Tb/s/mm2 aggregate interconnection capacity using this low-cost technology.

Performance evaluation of cognitive radio in advanced metering infrastructure communication

NASA Astrophysics Data System (ADS)

Hiew, Yik-Kuan; Mohd Aripin, Norazizah; Din, Norashidah Md

2016-03-01

Smart grid is an intelligent electricity grid system. A reliable two-way communication system is required to transmit both critical and non-critical smart grid data. However, it is difficult to locate a huge chunk of dedicated spectrum for smart grid communications. Hence, cognitive radio based communication is applied. Cognitive radio allows smart grid users to access licensed spectrums opportunistically with the constraint of not causing harmful interference to licensed users. In this paper, a cognitive radio based smart grid communication framework is proposed. Smart grid framework consists of Home Area Network (HAN) and Advanced Metering Infrastructure (AMI), while AMI is made up of Neighborhood Area Network (NAN) and Wide Area Network (WAN). In this paper, the authors only report the findings for AMI communication. AMI is smart grid domain that comprises smart meters, data aggregator unit, and billing center. Meter data are collected by smart meters and transmitted to data aggregator unit by using cognitive 802.11 technique; data aggregator unit then relays the data to billing center using cognitive WiMAX and TV white space. The performance of cognitive radio in AMI communication is investigated using Network Simulator 2. Simulation results show that cognitive radio improves the latency and throughput performances of AMI. Besides, cognitive radio also improves spectrum utilization efficiency of WiMAX band from 5.92% to 9.24% and duty cycle of TV band from 6.6% to 10.77%.

Heterogeneous regional signal control : final report.

DOT National Transportation Integrated Search

2017-03-12

The goal of this project is to develop a comprehensive framework with a set of models to improve multi-modal traffic signal control, by incorporating advanced floating sensor data (e.g. GPS data, etc.) and traditional fixed sensor data (e.g. loop det...

Imaging the pleura.

PubMed

Mortensen, Chloe; Bhatnagar, Rahul; Edey, Anthony J

2012-11-01

Pleural disease is now recognized as an important subspecialty of pulmonary medicine, with increasing provision being made for specialist services and procedures. In response, the field of pleural imaging has advanced in recent years, especially with regard to ultrasound. Salient multimodality imaging techniques are discussed.

Selection of radio sources for Venus balloon-Pathfinder Delta-DOR navigation at 1.7 GHz

NASA Technical Reports Server (NTRS)

Liewer, K. M

1986-01-01

In order to increase the success rate of the Delta-DOR (Delta-Differential One-way Range) VLBI navigational support for the French-Soviet Venus Balloon and Halley Pathfinder projects, forty-four extragalactic radio sources were observed in advance of these projects to determine which were suitable for use as reference sources. Of these forty-four radio sources taken from the existing JPL radio source catalogue, thirty-six were determined to be of sufficient strength for use in Delta-DOR VLBI navigation.

Solar-geophysical data number 493, September 1985. Part 1: (Prompt reports). Data for August 1985, July 1985 and late data

NASA Technical Reports Server (NTRS)

Coffey, H. E. (Editor)

1985-01-01

Topics covered include: detailed index for 1985; data for August 1985--(IUWDS alert periods (Advanced and Worldwide), solar activity indices, solar flares, solar radio emission, Stanford mean solar magnetic field); (solar active regions, sudden ionospheric disturbances, solar radio spectral observations, cosmic ray measurements by neutron monitor, geomagnetic indices, radio propagation indices); and late data--calcium plage data.

Solar-geophysical data number 494, October 1985. Part 1: (Prompt reports). Data for September 1985, August 1985 and late data

NASA Technical Reports Server (NTRS)

Coffey, H. E. (Editor)

1985-01-01

Data for August and September 1985 on IUWDS alert periods (advance and worldwide), solar activity indices, solar flares, solar radio emission, Stanford mean solar magnetic fields, solar active regions, sudden ionospheric disturbances, solar radio spectral observations, cosmic ray measurements, geomagnetic indices, radio porpagation indices, inferred interplanetary magnetic field polarity, preliminary solar proton event list, and calcium plage are presented.

An adaptive field detection method for bridge scour monitoring using motion-sensing radio transponders (RFIDs).

DOT National Transportation Integrated Search

2014-01-01

A comprehensive field detection method is proposed that is aimed at developing advanced capability for : reliable monitoring, inspection and life estimation of bridge infrastructure. The goal is to utilize Motion-Sensing Radio Transponders (RFIDS) on...

Advanced capability RFID system

DOEpatents

Gilbert, Ronald W.; Steele, Kerry D.; Anderson, Gordon A.

2007-09-25

A radio-frequency transponder device having an antenna circuit configured to receive radio-frequency signals and to return modulated radio-frequency signals via continuous wave backscatter, a modulation circuit coupled to the antenna circuit for generating the modulated radio-frequency signals, and a microprocessor coupled to the antenna circuit and the modulation circuit and configured to receive and extract operating power from the received radio-frequency signals and to monitor inputs on at least one input pin and to generate responsive signals to the modulation circuit for modulating the radio-frequency signals. The microprocessor can be configured to generate output signals on output pins to associated devices for controlling the operation thereof. Electrical energy can be extracted and stored in an optional electrical power storage device.

Multimodal visualization interface for data management, self-learning and data presentation.

PubMed

Van Sint Jan, S; Demondion, X; Clapworthy, G; Louryan, S; Rooze, M; Cotten, A; Viceconti, M

2006-10-01

A multimodal visualization software, called the Data Manager (DM), has been developed to increase interdisciplinary communication around the topic of visualization and modeling of various aspects of the human anatomy. Numerous tools used in Radiology are integrated in the interface that runs on standard personal computers. The available tools, combined to hierarchical data management and custom layouts, allow analyzing of medical imaging data using advanced features outside radiological premises (for example, for patient review, conference presentation or tutorial preparation). The system is free, and based on an open-source software development architecture, and therefore updates of the system for custom applications are possible.

Conference Proceedings for the Advanced Multimodal Transportation Weather Services Partnership Initiatives

DOT National Transportation Integrated Search

1999-01-01

A symposium was held at the Volpe National Transportation Systems Center on September 28, 1998 to continue an active dialogue on issues related to the use of weather informaiton to support transportation decision making, safety, and efficiency. The o...

Passive Thermal Design Approach for the Space Communications and Navigation (SCaN) Testbed Experiment on the International Space Station (ISS)

NASA Technical Reports Server (NTRS)

Siamidis, John; Yuko, Jim

2014-01-01

The Space Communications and Navigation (SCaN) Program Office at NASA Headquarters oversees all of NASAs space communications activities. SCaN manages and directs the ground-based facilities and services provided by the Deep Space Network (DSN), Near Earth Network (NEN), and the Space Network (SN). Through the SCaN Program Office, NASA GRC developed a Software Defined Radio (SDR) testbed experiment (SCaN testbed experiment) for use on the International Space Station (ISS). It is comprised of three different SDR radios, the Jet Propulsion Laboratory (JPL) radio, Harris Corporation radio, and the General Dynamics Corporation radio. The SCaN testbed experiment provides an on-orbit, adaptable, SDR Space Telecommunications Radio System (STRS) - based facility to conduct a suite of experiments to advance the Software Defined Radio, Space Telecommunications Radio Systems (STRS) standards, reduce risk (Technology Readiness Level (TRL) advancement) for candidate Constellation future space flight hardware software, and demonstrate space communication links critical to future NASA exploration missions. The SCaN testbed project provides NASA, industry, other Government agencies, and academic partners the opportunity to develop and field communications, navigation, and networking technologies in the laboratory and space environment based on reconfigurable, software defined radio platforms and the STRS Architecture.The SCaN testbed is resident on the P3 Express Logistics Carrier (ELC) on the exterior truss of the International Space Station (ISS). The SCaN testbed payload launched on the Japanese Aerospace Exploration Agency (JAXA) H-II Transfer Vehicle (HTV) and was installed on the ISS P3 ELC located on the inboard RAM P3 site. The daily operations and testing are managed out of NASA GRC in the Telescience Support Center (TSC).

Advanced Contrast Agents for Multimodal Biomedical Imaging Based on Nanotechnology.

PubMed

Calle, Daniel; Ballesteros, Paloma; Cerdán, Sebastián

2018-01-01

Clinical imaging modalities have reached a prominent role in medical diagnosis and patient management in the last decades. Different image methodologies as Positron Emission Tomography, Single Photon Emission Tomography, X-Rays, or Magnetic Resonance Imaging are in continuous evolution to satisfy the increasing demands of current medical diagnosis. Progress in these methodologies has been favored by the parallel development of increasingly more powerful contrast agents. These are molecules that enhance the intrinsic contrast of the images in the tissues where they accumulate, revealing noninvasively the presence of characteristic molecular targets or differential physiopathological microenvironments. The contrast agent field is currently moving to improve the performance of these molecules by incorporating the advantages that modern nanotechnology offers. These include, mainly, the possibilities to combine imaging and therapeutic capabilities over the same theranostic platform or improve the targeting efficiency in vivo by molecular engineering of the nanostructures. In this review, we provide an introduction to multimodal imaging methods in biomedicine, the sub-nanometric imaging agents previously used and the development of advanced multimodal and theranostic imaging agents based in nanotechnology. We conclude providing some illustrative examples from our own laboratories, including recent progress in theranostic formulations of magnetoliposomes containing ω-3 poly-unsaturated fatty acids to treat inflammatory diseases, or the use of stealth liposomes engineered with a pH-sensitive nanovalve to release their cargo specifically in the acidic extracellular pH microenvironment of tumors.

vECTlab—A fully integrated multi-modality Monte Carlo simulation framework for the radiological imaging sciences

NASA Astrophysics Data System (ADS)

Peter, Jörg; Semmler, Wolfhard

2007-10-01

Alongside and in part motivated by recent advances in molecular diagnostics, the development of dual-modality instruments for patient and dedicated small animal imaging has gained attention by diverse research groups. The desire for such systems is high not only to link molecular or functional information with the anatomical structures, but also for detecting multiple molecular events simultaneously at shorter total acquisition times. While PET and SPECT have been integrated successfully with X-ray CT, the advance of optical imaging approaches (OT) and the integration thereof into existing modalities carry a high application potential, particularly for imaging small animals. A multi-modality Monte Carlo (MC) simulation approach at present has been developed that is able to trace high-energy (keV) as well as optical (eV) photons concurrently within identical phantom representation models. We show that the involved two approaches for ray-tracing keV and eV photons can be integrated into a unique simulation framework which enables both photon classes to be propagated through various geometry models representing both phantoms and scanners. The main advantage of such integrated framework for our specific application is the investigation of novel tomographic multi-modality instrumentation intended for in vivo small animal imaging through time-resolved MC simulation upon identical phantom geometries. Design examples are provided for recently proposed SPECT-OT and PET-OT imaging systems.

A comparison of mobility impacts on urban commuting between broadcast advisories and advanced traveler information services

DOT National Transportation Integrated Search

2004-02-01

This report explores the effectiveness of relying on commercial radio as a source of traveler information, and presents an approach to quantify mobility benefits from radio traffic advisories. The study, conducted for the Washington, DC, metropolitan...

Advances in solar radio astronomy

NASA Technical Reports Server (NTRS)

Kundu, M. R.

1982-01-01

The status of the observations and interpretations of the sun's radio emission covering the entire radio spectrum from millimeter wavelengths to hectometer and kilometer wavelengths is reviewed. Emphasis is given to the progress made in solar radio physics as a result of recent advances in plasma and radiation theory. It is noted that the capability now exists of observing the sun with a spatial resolution of approximately a second of arc and a temporal resolution of about a millisecond at centimeter wavelengths and of obtaining fast multifrequency two-dimensional pictures of the sun at meter and decameter wavelengths. A summary is given of the properties of nonflaring active regions at millimeter, centimeter, and meter-decameter wavelengths. The properties of centimeter wave bursts are discussed in connection with the high spatial resolution observations. The observations of the preflare build-up of an active region are reviewed. High spatial resolution observations (a few seconds of arc to approximately 1 arcsec) are discussed, with particular attention given to the one- and two-dimensional maps of centimeter-wavelength burst sources.

The concept and evolution of involved site radiation therapy for lymphoma.

PubMed

Specht, Lena; Yahalom, Joachim

2015-10-01

We describe the development of radiation therapy for lymphoma from extended field radiotherapy of the past to modern conformal treatment with involved site radiation therapy based on advanced imaging, three-dimensional treatment planning and advanced treatment delivery techniques. Today, radiation therapy is part of the multimodality treatment of lymphoma, and the irradiated tissue volume is much smaller than before, leading to highly significant reductions in the risks of long-term complications.

Advanced Optical Fibers for High power Fiber lasers

DTIC Science & Technology

2015-08-24

crystal fiber cladding . Advanced Optical Fibers for High Power Fiber Lasers http://dx.doi.org/10.5772/58958 223 lengths above the second-order mode cut...brightness multimode diode lasers for a given pump waveguide dimen‐ sion. In conventional double- clad fibers, low-index polymer coatings are typically used to...was below 0.2. The fiber was passive and there was no laser demonstration in this first attempt. The first cladding - pumping demonstration in an

Modern Radar Techniques for Geophysical Applications: Two Examples

NASA Technical Reports Server (NTRS)

Arokiasamy, B. J.; Bianchi, C.; Sciacca, U.; Tutone, G.; Zirizzotti, A.; Zuccheretti, E.

2005-01-01

The last decade of the evolution of radar was heavily influenced by the rapid increase in the information processing capabilities. Advances in solid state radio HF devices, digital technology, computing architectures and software offered the designers to develop very efficient radars. In designing modern radars the emphasis goes towards the simplification of the system hardware, reduction of overall power, which is compensated by coding and real time signal processing techniques. Radars are commonly employed in geophysical radio soundings like probing the ionosphere; stratosphere-mesosphere measurement, weather forecast, GPR and radio-glaciology etc. In the laboratorio di Geofisica Ambientale of the Istituto Nazionale di Geofisica e Vulcanologia (INGV), Rome, Italy, we developed two pulse compression radars. The first is a HF radar called AIS-INGV; Advanced Ionospheric Sounder designed both for the purpose of research and for routine service of the HF radio wave propagation forecast. The second is a VHF radar called GLACIORADAR, which will be substituting the high power envelope radar used by the Italian Glaciological group. This will be employed in studying the sub glacial structures of Antarctica, giving information about layering, the bed rock and sub glacial lakes if present. These are low power radars, which heavily rely on advanced hardware and powerful real time signal processing. Additional information is included in the original extended abstract.

The RadioSat (sm) network

NASA Technical Reports Server (NTRS)

Noreen, Gary K.

1991-01-01

The RadioSat network under development by radio Satellite Corporation will use mobile satellite (MSAT) technology to provide diverse personal communications, broadcast, and navigation services. The network will support these services simultaneously for integrated mobile radios throughout Canada and the United States. The RadioSat network takes advantage of several technological breakthroughs, all coming to fruition by the time the first MSAT satellite is launched in 1994. The most important of these breakthroughs is the enormous radiated power of each MSAT spacecraft - orders of magnitude greater than the radiated power of previous L-band spacecraft. Another important breakthrough is the development of advanced digital audio compression algorithms, enabling the transmission of broadcast quality music at moderate data rates. Finally, continuing dramatic increases in VLSI capabilities permit the production of complex, multi-function mobile satellite radios in very large quantities at prices little more than those of conventional car radios. In addition to performance breakthroughs and their economic implications to RadioSat, the design of the RadioSat network is reviewed.

Hedgehog Pathway Inhibition Radiosensitizes Non-Small Cell Lung Cancers

PubMed Central

Zeng, Jing; Aziz, Khaled; Chettiar, Sivarajan T.; Aftab, Blake T.; Armour, Michael; Gajula, Rajendra; Gandhi, Nishant; Salih, Tarek; Herman, Joseph M.; Wong, John; Rudin, Charles M.; Tran, Phuoc T.; Hales, Russell K.

2012-01-01

Purpose Despite improvements in chemoradiation, local control remains a major clinical problem in locally advanced non-small cell lung cancer. The Hedgehog pathway has been implicated in tumor recurrence by promoting survival of tumorigenic precursors and through effects on tumor-associated stroma. Whether Hedgehog inhibition can affect radiation efficacy in vivo has not been reported. Methods and Materials We evaluated the effects of a targeted Hedgehog inhibitor (HhAntag) and radiation on clonogenic survival of human non-small cell lung cancer lines in vitro. Using an A549 cell line xenograft model, we examined tumor growth, proliferation, apoptosis, and gene expression changes after concomitant HhAntag and radiation. In a transgenic mouse model of KrasG12D-induced and Twist1-induced lung adenocarcinoma, we assessed tumor response to radiation and HhAntag by serial micro-computed tomography (CT) scanning. Results In 4 human lung cancer lines in vitro, HhAntag showed little or no effect on radio-sensitivity. By contrast, in both the human tumor xenograft and murine inducible transgenic models, HhAntag enhanced radiation efficacy and delayed tumor growth. By use of the human xenograft model to differentiate tumor and stromal effects, mouse stromal cells, but not human tumor cells, showed significant and consistent downregulation of Hedgehog pathway gene expression. This was associated with increased tumor cell apoptosis. Conclusions Targeted Hedgehog pathway inhibition can increase in vivo radiation efficacy in lung cancer preclinical models. This effect is associated with pathway suppression in tumor-associated stroma. These data support clinical testing of Hedgehog inhibitors as a component of multimodality therapy for locally advanced non-small cell lung cancer. PMID:23182391

Modeling and analyzing the impact of advanced technologies on livability and multimodal transportation performance measures in arterial corridors : phase 2.

DOT National Transportation Integrated Search

2017-03-01

Transportation corridors are complex systems. Tradeoffs, particularly in terms of traffic mobility, transit performance, accessibility and pedestrian : interactions, are not well understood. When the focus is on motorized vehicle mobility and through...

Advanced Mathematics Communication beyond Modality of Sight

ERIC Educational Resources Information Center

Sedaghatjou, Mina

2018-01-01

This study illustrates how mathematical communication and learning are inherently multimodal and embodied; hence, sight-disabled students are also able to conceptualize visuospatial information and mathematical concepts through tactile and auditory activities. Adapting a perceptuomotor integration approach, the study shows that the lack of access…

The multi-modal Australian ScienceS Imaging and Visualization Environment (MASSIVE) high performance computing infrastructure: applications in neuroscience and neuroinformatics research

PubMed Central

Goscinski, Wojtek J.; McIntosh, Paul; Felzmann, Ulrich; Maksimenko, Anton; Hall, Christopher J.; Gureyev, Timur; Thompson, Darren; Janke, Andrew; Galloway, Graham; Killeen, Neil E. B.; Raniga, Parnesh; Kaluza, Owen; Ng, Amanda; Poudel, Govinda; Barnes, David G.; Nguyen, Toan; Bonnington, Paul; Egan, Gary F.

2014-01-01

The Multi-modal Australian ScienceS Imaging and Visualization Environment (MASSIVE) is a national imaging and visualization facility established by Monash University, the Australian Synchrotron, the Commonwealth Scientific Industrial Research Organization (CSIRO), and the Victorian Partnership for Advanced Computing (VPAC), with funding from the National Computational Infrastructure and the Victorian Government. The MASSIVE facility provides hardware, software, and expertise to drive research in the biomedical sciences, particularly advanced brain imaging research using synchrotron x-ray and infrared imaging, functional and structural magnetic resonance imaging (MRI), x-ray computer tomography (CT), electron microscopy and optical microscopy. The development of MASSIVE has been based on best practice in system integration methodologies, frameworks, and architectures. The facility has: (i) integrated multiple different neuroimaging analysis software components, (ii) enabled cross-platform and cross-modality integration of neuroinformatics tools, and (iii) brought together neuroimaging databases and analysis workflows. MASSIVE is now operational as a nationally distributed and integrated facility for neuroinfomatics and brain imaging research. PMID:24734019

Optimizing multimodality treatment for head and neck cancer in rural India.

PubMed

Trivedi, N P; Trivedi, P; Trivedi, H; Trivedi, S; Trivedi, N

2012-01-01

Multimodality treatment of head and neck cancer in rural India is not always feasible due to lack of infrastructure and logistics. To demonstrate the feasibility of multimodality treatment for head and neck cancer in a community setting in rural India. Community cancer center, retrospective review. This article focuses on practice environment in a cancer clinic in rural India. We evaluated patient profile, treatment protocols, infrastructure availability, factors impacting treatment decisions, cost estimations, completion of treatment, and major treatment-related complications for the patient population treated in our clinic for a 2-year period. A total of 230 head and neck cancer patients were treated with curative intent. Infrastructure support included basic operating room facility (cautery machine, suction, drill system, microscope, and anesthesia machine without ventilator support), blood bank, histopathology laboratory, and computerized tomography machine. Radiation therapy (RT) facility was available in a nearby city, about 75 km away. One hundred and fifty-four (67%) patients presented at an advanced stage, with 138 (60%) receiving multimodality treatment. One hundred and eighty-four (80%) patients underwent primary surgery and 167 (73%) received radiotherapy. Two hundred and twelve (92%) patients completed the treatment, 60 (26%) were lost to follow-up at 18-month median follow-up (range 12-26 months), with 112 patients (66%) being alive, disease free. Totally 142 were major head neck surgeries with 25 free flap reconstructions and 41 regional flaps. There were 15 (6%) major post-op complications and two perioperative mortalities. Average cost of treatment for single modality treatment was approximately 40,000 INR and for multimodality treatment was 80,000 INR. This study demonstrates that it is feasible to provide basic multimodality treatment to head and neck cancer patients in the community.

Spatial accessibility to healthcare services in Shenzhen, China: improving the multi-modal two-step floating catchment area method by estimating travel time via online map APIs.

PubMed

Tao, Zhuolin; Yao, Zaoxing; Kong, Hui; Duan, Fei; Li, Guicai

2018-05-09

Shenzhen has rapidly grown into a megacity in the recent decades. It is a challenging task for the Shenzhen government to provide sufficient healthcare services. The spatial configuration of healthcare services can influence the convenience for the consumers to obtain healthcare services. Spatial accessibility has been widely adopted as a scientific measurement for evaluating the rationality of the spatial configuration of healthcare services. The multi-modal two-step floating catchment area (2SFCA) method is an important advance in the field of healthcare accessibility modelling, which enables the simultaneous assessment of spatial accessibility via multiple transport modes. This study further develops the multi-modal 2SFCA method by introducing online map APIs to improve the estimation of travel time by public transit or by car respectively. As the results show, the distribution of healthcare accessibility by multi-modal 2SFCA shows significant spatial disparity. Moreover, by dividing the multi-modal accessibility into car-mode and transit-mode accessibility, this study discovers that the transit-mode subgroup is disadvantaged in the competition for healthcare services with the car-mode subgroup. The disparity in transit-mode accessibility is the main reason of the uneven pattern of healthcare accessibility in Shenzhen. The findings suggest improving the public transit conditions for accessing healthcare services to reduce the disparity of healthcare accessibility. More healthcare services should be allocated in the eastern and western Shenzhen, especially sub-districts in Dapeng District and western Bao'an District. As these findings cannot be drawn by the traditional single-modal 2SFCA method, the advantage of the multi-modal 2SFCA method is significant to both healthcare studies and healthcare system planning.

Multimodal imaging of lung cancer and its microenvironment (Conference Presentation)

NASA Astrophysics Data System (ADS)

Hariri, Lida P.; Niederst, Matthew J.; Mulvey, Hillary; Adams, David C.; Hu, Haichuan; Chico Calero, Isabel; Szabari, Margit V.; Vakoc, Benjamin J.; Hasan, Tayyaba; Bouma, Brett E.; Engelman, Jeffrey A.; Suter, Melissa J.

2016-03-01

Despite significant advances in targeted therapies for lung cancer, nearly all patients develop drug resistance within 6-12 months and prognosis remains poor. Developing drug resistance is a progressive process that involves tumor cells and their microenvironment. We hypothesize that microenvironment factors alter tumor growth and response to targeted therapy. We conducted in vitro studies in human EGFR-mutant lung carcinoma cells, and demonstrated that factors secreted from lung fibroblasts results in increased tumor cell survival during targeted therapy with EGFR inhibitor, gefitinib. We also demonstrated that increased environment stiffness results in increased tumor survival during gefitinib therapy. In order to test our hypothesis in vivo, we developed a multimodal optical imaging protocol for preclinical intravital imaging in mouse models to assess tumor and its microenvironment over time. We have successfully conducted multimodal imaging of dorsal skinfold chamber (DSC) window mice implanted with GFP-labeled human EGFR mutant lung carcinoma cells and visualized changes in tumor development and microenvironment facets over time. Multimodal imaging included structural OCT to assess tumor viability and necrosis, polarization-sensitive OCT to measure tissue birefringence for collagen/fibroblast detection, and Doppler OCT to assess tumor vasculature. Confocal imaging was also performed for high-resolution visualization of EGFR-mutant lung cancer cells labeled with GFP, and was coregistered with OCT. Our results demonstrated that stromal support and vascular growth are essential to tumor progression. Multimodal imaging is a useful tool to assess tumor and its microenvironment over time.

The telecommunications and data acquisition report

NASA Technical Reports Server (NTRS)

Renzetti, N. A. (Editor)

1982-01-01

Developments in Earth-based radio technology are reported. The Deep Space Network is discussed in terms of its advanced systems, network and facility engineering and implementation, operations, and energy sources. Problems in pulse communication and radio frequency interference are addressed with emphasis on pulse position modulation and laser beam collimation.

75 FR 52472 - Spectrum Requirements for Advanced Medical Technologies

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-26

... requires a ``Commission- approved human body simulator and test technique,'' fails to provide sufficient... therapeutic purposes in humans. In the MedRadio Order, the Commission also adopted service and technical rules... devices--the more flexible MedRadio rules accommodate body-worn as well as implanted medical devices...

Television Sweep Circuits and Picture Signal Path; Radio and Television Service--Advanced: 9787.02.

ERIC Educational Resources Information Center

Dade County Public Schools, Miami, FL.

This course outline is designed to give students a working knowledge of radio and television theory and servicing techniques. Course content includes goals, specific block objectives, resistance-capacitance circuit characteristics, sawtooth generators sawtooth generator control and production of scanning waveforms, deflection systems, composite…

Solar-geophysical data number 490, June 1985. Part 1: (Prompt reports). Data for May 1985, April 1985 and late data

NASA Technical Reports Server (NTRS)

Coffey, H. E. (Editor)

1985-01-01

Contents include: detailed index for 1984 to 1985; data for May 1985--(IUWDS alert periods (Advance and Worldwide) solar activity indices, solar flares, solar radio emission, Stanford mean solar magnetic field); data for April 1985--(solar active regions, sudden ionospheric disturbances, solar radio spectral observations, cosmic ray measurements by neutron monitor, geomagnetic indices, radio propagation indices); and late data--(geomagnetic indices, cosmic rays, calcium plage data).

How acute and chronic alcohol consumption affects brain networks: insights from multimodal neuroimaging.

PubMed

Schulte, Tilman; Oberlin, Brandon G; Kareken, David A; Marinkovic, Ksenija; Müller-Oehring, Eva M; Meyerhoff, Dieter J; Tapert, Susan

2012-12-01

Multimodal imaging combining 2 or more techniques is becoming increasingly important because no single imaging approach has the capacity to elucidate all clinically relevant characteristics of a network. This review highlights recent advances in multimodal neuroimaging (i.e., combined use and interpretation of data collected through magnetic resonance imaging [MRI], functional MRI, diffusion tensor imaging, positron emission tomography, magnetoencephalography, MR perfusion, and MR spectroscopy methods) that leads to a more comprehensive understanding of how acute and chronic alcohol consumption affect neural networks underlying cognition, emotion, reward processing, and drinking behavior. Several innovative investigators have started utilizing multiple imaging approaches within the same individual to better understand how alcohol influences brain systems, both during intoxication and after years of chronic heavy use. Their findings can help identify mechanism-based therapeutic and pharmacological treatment options, and they may increase the efficacy and cost effectiveness of such treatments by predicting those at greatest risk for relapse. Copyright © 2012 by the Research Society on Alcoholism.

Entanglement enhancement in multimode integrated circuits

NASA Astrophysics Data System (ADS)

Léger, Zacharie M.; Brodutch, Aharon; Helmy, Amr S.

2018-06-01

The faithful distribution of entanglement in continuous-variable systems is essential to many quantum information protocols. As such, entanglement distillation and enhancement schemes are a cornerstone of many applications. The photon subtraction scheme offers enhancement with a relatively simple setup and has been studied in various scenarios. Motivated by recent advances in integrated optics, particularly the ability to build stable multimode interferometers with squeezed input states, a multimodal extension to the enhancement via photon subtraction protocol is studied. States generated with multiple squeezed input states, rather than a single input source, are shown to be more sensitive to the enhancement protocol, leading to increased entanglement at the output. Numerical results show the gain in entanglement is not monotonic with the number of modes or the degree of squeezing in the additional modes. Consequently, the advantage due to having multiple squeezed input states can be maximized when the number of modes is still relatively small (e.g., four). The requirement for additional squeezing is within the current realm of implementation, making this scheme achievable with present technologies.

GLOBECOM '88 - IEEE Global Telecommunications Conference and Exhibition, Hollywood, FL, Nov. 28-Dec. 1, 1988, Conference Record. Volumes 1, 2, & 3

NASA Astrophysics Data System (ADS)

Various papers on communications for the information age are presented. Among the general topics considered are: telematic services and terminals, satellite communications, telecommunications mangaement network, control of integrated broadband networks, advances in digital radio systems, the intelligent network, broadband networks and services deployment, future switch architectures, performance analysis of computer networks, advances in spread spectrum, optical high-speed LANs, and broadband switching and networks. Also addressed are: multiple access protocols, video coding techniques, modulation and coding, photonic switching, SONET terminals and applications, standards for video coding, digital switching, progress in MANs, mobile and portable radio, software design for improved maintainability, multipath propagation and advanced countermeasure, data communication, network control and management, fiber in the loop, network algorithm and protocols, and advances in computer communications.

Introduction to the Special Issue on Digital Signal Processing in Radio Astronomy

NASA Astrophysics Data System (ADS)

Price, D. C.; Kocz, J.; Bailes, M.; Greenhill, L. J.

2016-03-01

Advances in astronomy are intimately linked to advances in digital signal processing (DSP). This special issue is focused upon advances in DSP within radio astronomy. The trend within that community is to use off-the-shelf digital hardware where possible and leverage advances in high performance computing. In particular, graphics processing units (GPUs) and field programmable gate arrays (FPGAs) are being used in place of application-specific circuits (ASICs); high-speed Ethernet and Infiniband are being used for interconnect in place of custom backplanes. Further, to lower hurdles in digital engineering, communities have designed and released general-purpose FPGA-based DSP systems, such as the CASPER ROACH board, ASTRON Uniboard, and CSIRO Redback board. In this introductory paper, we give a brief historical overview, a summary of recent trends, and provide an outlook on future directions.

76 FR 38614 - Transportation Infrastructure/Multimodal Products and Services Trade Mission to Doha, Qatar, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-01

...- modal freight and intelligent supply chain management, provides significant business opportunities in... technologies, supply chain systems and strategies; mass transportation systems; advanced vehicle technologies... opportunities for U.S. engineers, program management firms, and manufacturers to contribute to the creation of...

Improvement of surgical margin with a coupled saline-radio-frequency device for multiple colorectal liver metastases.

PubMed

Ogata, Satoshi; Kianmanesh, Reza; Varma, Deepak; Belghiti, Jacques

2005-01-01

Complete resection of colorectal liver metastases (LM) has been the only curative treatment. However, when LM are multiple and bilobar, only a few patients are candidates for curative surgery. We report on a 53-year-old woman with synchronous multiple and bilobar LM from sigmoidal cancer who became resectable after a multimodal strategy including preoperative systemic chemotherapy and two-step surgery. The spectacular decrease in tumor size after systemic chemotherapy led us to perform two-step surgery, including right portal-vein ligation and left liver metastasectomies, with a coupled saline-radiofrequency device, in order to improve the surgical margin. An extended right hepatectomy was performed later to remove the remaining right liver lesions. The patient was discharged after 28 days without major complication and was recurrence-free 14 months later. We conclude that improving the surgical margin with a coupled saline-radiofrequency device is feasible and effective, avoiding small remnant liver even after multiple tumorectomies. The multimodal strategy, including preoperative chemotherapy, two-step surgery, and tumorectomies, using a coupled saline-radiofrequency device, could increase the number of patients with diffuse bilobar liver metastases who can benefit from liver resection.

Multimodal device for assessment of skin malformations

NASA Astrophysics Data System (ADS)

Bekina, A.; Garancis, V.; Rubins, U.; Spigulis, J.; Valeine, L.; Berzina, A.

2013-11-01

A variety of multi-spectral imaging devices is commercially available and used for skin diagnostics and monitoring; however, an alternative cost-efficient device can provide an advanced spectral analysis of skin. A compact multimodal device for diagnosis of pigmented skin lesions was developed and tested. A polarized LED light source illuminates the skin surface at four different wavelengths - blue (450 nm), green (545 nm), red (660 nm) and infrared (940 nm). Spectra of reflected light from the 25 mm wide skin spot are imaged by a CMOS sensor. Four spectral images are obtained for mapping of the main skin chromophores. The specific chromophore distribution differences between different skin malformations were analyzed and information of subcutaneous structures was consecutively extracted.

DBSAR's First Multimode Flight Campaign

NASA Technical Reports Server (NTRS)

Rincon, Rafael F.; Vega, Manuel; Buenfil, Manuel; Geist, Alessandro; Hilliard, Lawrence; Racette, Paul

2010-01-01

The Digital Beamforming SAR (DBSAR) is an airborne imaging radar system that combines phased array technology, reconfigurable on-board processing and waveform generation, and advances in signal processing to enable techniques not possible with conventional SARs. The system exploits the versatility inherently in phased-array technology with a state-of-the-art data acquisition and real-time processor in order to implement multi-mode measurement techniques in a single radar system. Operational modes include scatterometry over multiple antenna beams, Synthetic Aperture Radar (SAR) over several antenna beams, or Altimetry. The radar was flight tested in October 2008 on board of the NASA P3 aircraft over the Delmarva Peninsula, MD. The results from the DBSAR system performance is presented.

Solar-Geophysical Data Number 496, February 1986. Part 1: (Prompt reports). Data for January 1986,December 1985 and late data

NASA Technical Reports Server (NTRS)

Coffey, H. E.

1986-01-01

Solar-Geophysical Data Number 498, February 1986, Part 1 (Prompt Reports), Data for January 1986, December 1985 and Late Data contains the following:detailed index for 1985-86; data for January 1986--(IUWDS alert periods (advanced and worldwide), Solar activity indices, Solar flares, Solar radio emission, Vostok inferred interplanetary magnetic field polarity, Stanford mean solar magnetic field); data for December 1985--(Solar active regions, Sudden ionospheric disturbances, Solar radio spectral observations, Cosmic ray measurements by neutron monitor, Geomagnetic indices, Radio propagation indices); late data--(Solar radio emission Nancay interferometric chart December 1985, Solar radio spectral observations Culgoora May 1985, Geomagnetic indices sudden commencements November 1985, Calcium plage data).

Medical Image Retrieval: A Multimodal Approach

PubMed Central

Cao, Yu; Steffey, Shawn; He, Jianbiao; Xiao, Degui; Tao, Cui; Chen, Ping; Müller, Henning

2014-01-01

Medical imaging is becoming a vital component of war on cancer. Tremendous amounts of medical image data are captured and recorded in a digital format during cancer care and cancer research. Facing such an unprecedented volume of image data with heterogeneous image modalities, it is necessary to develop effective and efficient content-based medical image retrieval systems for cancer clinical practice and research. While substantial progress has been made in different areas of content-based image retrieval (CBIR) research, direct applications of existing CBIR techniques to the medical images produced unsatisfactory results, because of the unique characteristics of medical images. In this paper, we develop a new multimodal medical image retrieval approach based on the recent advances in the statistical graphic model and deep learning. Specifically, we first investigate a new extended probabilistic Latent Semantic Analysis model to integrate the visual and textual information from medical images to bridge the semantic gap. We then develop a new deep Boltzmann machine-based multimodal learning model to learn the joint density model from multimodal information in order to derive the missing modality. Experimental results with large volume of real-world medical images have shown that our new approach is a promising solution for the next-generation medical imaging indexing and retrieval system. PMID:26309389

Advanced Transceivers for Firefighters

NASA Technical Reports Server (NTRS)

Blood, B. D.; Gandhi, O. P.; Radke, R. E.

1986-01-01

Report presents concept of improved portable radio transceiver for firefighters. Based in part on study of propagation of radio waves in such environments as high-rise buildings, ships, and tunnels. Study takes into account possible health hazard posed by personal tranceivers and needs and wishes expressed by firefighters in interviews. Conceptual radio attaches to clothing to allow hands-free use; voice-actuated with microphone worn at throat. Speaker placed near wearer's shoulder. Flexible antenna placed either horizontally across shoulders, vertically at one shoulder, or on transceiver itself.

Advanced Techniques of Artificial Networks Design for Radio Signal Detection

NASA Astrophysics Data System (ADS)

Danilin, S. N.; Shchanikov, S. A.; Iventev, A. A.; Zuev, A. D.

2018-05-01

This paper is concerned with the issue of secure radio communication of data between manned aircrafts, unmanned drones and control services. It is indicated that the use of artificial neural networks (ANN) enables correct identification of messages transmitted through radio channels and enhances identification quality by every measure. The authors designed and implemented a simulation modeling technology for ANN development, which enables signal detection with required accuracy in the context of noise jamming, natural and other types of noise.

A versatile phenotyping system and analytics platform reveals diverse temporal responses to water availability in Setaria

USDA-ARS?s Scientific Manuscript database

With rapid advances in DNA sequencing, phenotyping has become the rate-limiting step in using large-scale genomic data to understand and improve agricultural crops. Here, the Bellwether Phenotyping platform for controlled-environment plant growth and automated, multimodal phenotyping is described. T...

Does Fear Reactivity during Exposure Predict Panic Symptom Reduction?

ERIC Educational Resources Information Center

Meuret, Alicia E.; Seidel, Anke; Rosenfield, Benjamin; Hofmann, Stefan G.; Rosenfield, David

2012-01-01

Objective: Fear reactivity during exposure is a commonly used indicator of learning and overall therapy outcome. The objective of this study was to assess the predictive value of fear reactivity during exposure using multimodal indicators and an advanced analytical design. We also investigated the degree to which treatment condition (cognitive…

Multimodal Literacies in Science: Currency, Coherence and Focus

ERIC Educational Resources Information Center

Klein, Perry D.; Kirkpatrick, Lori C.

2010-01-01

Since the 1990s, researchers have increasingly drawn attention to the multiplicity of representations used in science. This issue of "RISE" advances this line of research by placing such representations at the centre of science teaching and learning. The authors show that representations do not simply transmit scientific information; they are…

Embedded 100 Gbps Photonic Components

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kuznia, Charlie

This innovation to fiber optic component technology increases the performance, reduces the size and reduces the power consumption of optical communications within dense network systems, such as advanced distributed computing systems and data centers. VCSEL technology is enabling short-reach (< 100 m) and >100 Gbps optical interconnections over multi-mode fiber in commercial applications.

Multimodal Application for Foreign Language Teaching

ERIC Educational Resources Information Center

Magal-Royo, Teresa; Gimenez-Lopez, Jose Luis; Pairy, Blas; Garcia-Laborda, Jesus; Gonzalez-Del Rio, Jimena

2011-01-01

The current development of educational applications for language learning has experienced a qualitative change in the criteria of interaction between users and devices due to the technological advances of input and output data through keyboard, mouse, stylus, tactile screen, etc. The multiple interactions generated in a natural way by humans…

Dictionary of Radio and Television.

ERIC Educational Resources Information Center

Pannett, W. E.

This dictionary presents definitions of both the well-established terms and many new ones that have come into use with the advances that have taken place in the fields of radio and television. In many cases extended definitions are given in order to describe briefly elementary principles and circuits, while newer and more complex devices and…

Reconfigurable, Intelligently-Adaptive, Communication System, an SDR Platform

NASA Technical Reports Server (NTRS)

Roche, Rigoberto

2016-01-01

The Space Telecommunications Radio System (STRS) provides a common, consistent framework to abstract the application software from the radio platform hardware. STRS aims to reduce the cost and risk of using complex, configurable and reprogrammable radio systems across NASA missions. The Glenn Research Center (GRC) team made a software-defined radio (SDR) platform STRS compliant by adding an STRS operating environment and a field programmable gate array (FPGA) wrapper, capable of implementing each of the platforms interfaces, as well as a test waveform to exercise those interfaces. This effort serves to provide a framework toward waveform development on an STRS compliant platform to support future space communication systems for advanced exploration missions. Validated STRS compliant applications provided tested code with extensive documentation to potentially reduce risk, cost and efforts in development of space-deployable SDRs. This paper discusses the advantages of STRS, the integration of STRS onto a Reconfigurable, Intelligently-Adaptive, Communication System (RIACS) SDR platform, the sample waveform, and wrapper development efforts. The paper emphasizes the infusion of the STRS Architecture onto the RIACS platform for potential use in next generation SDRs for advance exploration missions.

Recent advances in the preparation and application of multifunctional iron oxide and liposome-based nanosystems for multimodal diagnosis and therapy

PubMed Central

Marciello, Marzia; Pellico, Juan; Fernandez-Barahona, Irene; Herranz, Fernando; Ruiz-Cabello, Jesus

2016-01-01

Nowadays, thanks to the successful discoveries in the biomedical field achieved in the last two decades, a deeper understanding about the complexity of mechanistic aspects of different pathological processes has been obtained. As a consequence, even the standard therapeutic protocols have undergone a vast redesign. In fact, the awareness about the necessity to progress towards a combined multitherapy in order to potentially increase the final healing chances has become a reality. One of the crucial elements of this novel approach is that large amounts of detailed information are highly needed and in vivo imaging techniques represent one of the most powerful tools to visualize and monitor the pathological state of the patient. To this scope, due to their unique features, nanostructured materials have emerged as attractive elements for the development of multifunctional tools for diagnosis and therapy. Hence, in this review, the most recent and relevant advances achieved by applying multifunctional nanostructures in multimodal theranosis of different diseases will be discussed. In more detail, the preparation and application of single multifunctional nano-radiotracers based on iron oxides and enabling PET/MRI dual imaging will be firstly detailed. After that, especially considering their highly promising clinical potential, the preparation and application of multifunctional liposomes useful for multimodal imaging and therapy will be reviewed. In both cases, a special focus will be set on the application of such a multifunctional nanocarriers in cancer as well as cardiovascular diseases. PMID:27920894

75 FR 47141 - Review of Personal Radio Services Rules

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-04

...In this document, the Commission proposes to update, reorganize, simplify and streamline its Personal Radio Services rules to reflect technological advances and other changes in the way the American public uses the Personal Radio Services. In addition to improving the clarity of the rules, this document includes proposals intended to reduce unnecessary regulatory burdens on users, improve spectrum use, provide for enhanced equipment operating features, and promote the safety and consumer interests of operators. The document also proposes to reclassify one of the existing Personal Radio Services, specifically the 218-219 MHz service, as a Miscellaneous Wireless Communications Service, and accordingly move its rules from one part to another.

Application of the mid-IR radio correlation to the Ĝ sample and the search for advanced extraterrestrial civilisations

NASA Astrophysics Data System (ADS)

Garrett, M. A.

2015-09-01

Wright et al. (2014, ApJ, 792, 26) have embarked on a search for advanced Karadashev Type III civilisations via the compilation of a sample of sources with extreme mid-IR emission and colours. The aim is to furnish a list of candidate galaxies that might harbour an advanced Kardashev Type III civilisation; in this scenario, the mid-IR emission is then primarily associated with waste heat energy by-products. I apply the mid-IR radio correlation to this Glimpsing Heat from Alien Technology (Ĝ) sample, a catalogue of 93 candidate galaxies compiled by Griffith et al. (2015, ApJS, 217, 25). I demonstrate that the mid-IR and radio luminosities are correlated for the sample, determining a k-corrected value of q22 = 1.35 ± 0.42. By comparison, a similar measurement for 124 galaxies drawn from the First Look Survey (FLS) has q22 = 0.87 ± 0.27. The statistically significant difference of the mean value of q22 for these two samples, taken together with their more comparable far-IR properties, suggests that the Ĝ sample shows excessive emission in the mid-IR. The fact that the Ĝ sample largely follows the mid-IR radio correlation strongly suggests that the vast majority of these sources are associated with galaxies in which natural astrophysical processes are dominant. This simple application of the mid-IR radio correlation can substantially reduce the number of false positives in the Ĝ catalogue since galaxies occupied by advanced Kardashev Type III civilisations would be expected to exhibit very high values of q. I identify nine outliers in the sample with q22> 2 of which at least three have properties that are relatively well explained via standard astrophysical interpretations e.g. dust emission associated with nascent star formation and/or nuclear activity from a heavily obscured AGN. The other outliers have not been studied in any great detail, and are deserving of further observation. I also note that the comparison of resolved mid-IR and radio images of galaxies on sub-galactic (kpc) scales can also be useful in identifying and recognising artificial mid-IR emission from less advanced intermediate Type II/III civilisations. Nevertheless, from the bulk properties of the Ĝ sample, I conclude that Kardashev Type III civilisations are either very rare or do not exist in the local Universe. Table 1 is available in electronic form at http://www.aanda.org

Novel technologies and theoretical models in radiation therapy of cancer patients using 6.3 MeV fast neutrons produced by U-120 cyclotron

NASA Astrophysics Data System (ADS)

Musabaeva, L. I.; Startseva, Zh. A.; Gribova, O. V.; Velikaya, V. V.; Lisin, V. A.

2016-08-01

The analysis of clinical use of neutron therapy with 6 MeV fast neutrons compared to conventional radiation therapy was carried out. The experience of using neutron and mixed neutron and photon therapy in patients with different radio-resistant malignant tumors shows the necessity of further studies and development of the novel approaches to densely-ionizing radiation. The results of dosimetry and radiobiological studies have been the basis for planning clinical programs for neutron therapy. Clinical trials over the past 30 years have shown that neutron therapy successfully destroys radio-resistant cancers, including salivary gland tumors, adenoidcystic carcinoma, inoperable sarcomas, locally advanced head and neck tumors, and locally advanced prostate cancer. Radiation therapy with 6.3 MeV fast neutrons used alone and in combination with photon therapy resulted in improved long-term treatment outcomes in patients with radio-resistant malignant tumors.

M3BA: A Mobile, Modular, Multimodal Biosignal Acquisition Architecture for Miniaturized EEG-NIRS-Based Hybrid BCI and Monitoring.

PubMed

von Luhmann, Alexander; Wabnitz, Heidrun; Sander, Tilmann; Muller, Klaus-Robert

2017-06-01

For the further development of the fields of telemedicine, neurotechnology, and brain-computer interfaces, advances in hybrid multimodal signal acquisition and processing technology are invaluable. Currently, there are no commonly available hybrid devices combining bioelectrical and biooptical neurophysiological measurements [here electroencephalography (EEG) and functional near-infrared spectroscopy (NIRS)]. Our objective was to design such an instrument in a miniaturized, customizable, and wireless form. We present here the design and evaluation of a mobile, modular, multimodal biosignal acquisition architecture (M3BA) based on a high-performance analog front-end optimized for biopotential acquisition, a microcontroller, and our openNIRS technology. The designed M3BA modules are very small configurable high-precision and low-noise modules (EEG input referred noise @ 500 SPS 1.39 μV pp , NIRS noise equivalent power NEP 750 nm = 5.92 pW pp , and NEP 850 nm = 4.77 pW pp ) with full input linearity, Bluetooth, 3-D accelerometer, and low power consumption. They support flexible user-specified biopotential reference setups and wireless body area/sensor network scenarios. Performance characterization and in-vivo experiments confirmed functionality and quality of the designed architecture. Telemedicine and assistive neurotechnology scenarios will increasingly include wearable multimodal sensors in the future. The M3BA architecture can significantly facilitate future designs for research in these and other fields that rely on customized mobile hybrid biosignal modal biosignal acquisition architecture (M3BA), multimodal, near-infrared spectroscopy (NIRS), wireless body area network (WBAN), wireless body sensor network (WBSN).

Approaches, field considerations and problems associated with radio tracking carnivores

USGS Publications Warehouse

Sargeant, A.B.; Amlaner, C. J.; MacDonald, D.W.

1979-01-01

The adaptation of radio tracking to ecological studies was a major technological advance affecting field investigations of animal movements and behavior. Carnivores have been the recipients of much attention with this new technology and study approaches have varied from simple to complex. Equipment performance has much improved over the years, but users still face many difficulties. The beginning of all radio tracking studies should be a precise definition of objectives. Study objectives dictate type of gear required and field procedures. Field conditions affect equipment performance and investigator ability to gather data. Radio tracking carnivores is demanding and generally requires greater time than anticipated. Problems should be expected and planned for in study design. Radio tracking can be an asset in carnivore studies but caution is needed in its application.

Radio frequency interference mitigation using deep convolutional neural networks

NASA Astrophysics Data System (ADS)

Akeret, J.; Chang, C.; Lucchi, A.; Refregier, A.

2017-01-01

We propose a novel approach for mitigating radio frequency interference (RFI) signals in radio data using the latest advances in deep learning. We employ a special type of Convolutional Neural Network, the U-Net, that enables the classification of clean signal and RFI signatures in 2D time-ordered data acquired from a radio telescope. We train and assess the performance of this network using the HIDE &SEEK radio data simulation and processing packages, as well as early Science Verification data acquired with the 7m single-dish telescope at the Bleien Observatory. We find that our U-Net implementation is showing competitive accuracy to classical RFI mitigation algorithms such as SEEK's SUMTHRESHOLD implementation. We publish our U-Net software package on GitHub under GPLv3 license.

SArdinia Roach2-based Digital Architecture for Radio Astronomy (SARDARA)

NASA Astrophysics Data System (ADS)

Melis, A.; Concu, R.; Trois, A.; Possenti, A.; Bocchinu, A.; Bolli, P.; Burgay, M.; Carretti, E.; Castangia, P.; Casu, S.; Pestellini, C. Cecchi; Corongiu, A.; D’Amico, N.; Egron, E.; Govoni, F.; Iacolina, M. N.; Murgia, M.; Pellizzoni, A.; Perrodin, D.; Pilia, M.; Pisanu, T.; Poddighe, A.; Poppi, S.; Porceddu, I.; Tarchi, A.; Vacca, V.; Aresu, G.; Bachetti, M.; Barbaro, M.; Casula, A.; Ladu, A.; Leurini, S.; Loi, F.; Loru, S.; Marongiu, P.; Maxia, P.; Mazzarella, G.; Migoni, C.; Montisci, G.; Valente, G.; Vargiu, G.

The Sardinia Radio Telescope (SRT) is a 64-m, fully-steerable single-dish radio telescope that was recently commissioned both technically and scientifically with regard to the basic observing modes. In order to improve the scientific capability and cover all the requirements for an advanced single-dish radio telescope, we developed the SArdinia Roach2-based Digital Architecture for Radio Astronomy (SARDARA), a wide-band, multi-feed, general-purpose, and reconfigurable digital platform, whose preliminary setup was used in the early science program of the SRT in 2016. In this paper, we describe the backend both in terms of its scientific motivation and technical design, how it has been interfaced with the telescope environment during its development and, finally, its scientific commissioning in different observing modes with single-feed receivers.

A review of ionospheric effects on Earth-space propagation

NASA Technical Reports Server (NTRS)

Klobuchar, J. A.

1984-01-01

A short description is given of each ionospheric total electron content (TEC) effect upon radio waves, along with a representative value of the magnitude of each of these effects under normal ionospheric conditions. A discussion is given of the important characteristics of average ionospheric TEC behavior and the temporal and spatial variability of TEC. Radio waves undergo several effects when they pass through the Earth's ionosphere. One of the most important of these effects is a retardation, or group delay, on the modulation or information carried on the radio wave that is due to its encounter with the free, thermal electrons in the Earth's ionosphere. Other effects the ionosphere has on radio waves include: radio frequency (RF) carrier phase advance; Doppler shift of the RF carrier of the radio wave; Faraday rotation of the plane of polarization of linearly polarized waves; angular refraction or bending of the radio wave path as it travels through the ionosphere; and amplitude and phase scintillations.

The Telecommunications and Data Acquisition Report

NASA Technical Reports Server (NTRS)

Posner, E. C. (Editor)

1984-01-01

Activities in space communication, radio navigation, radio science, and ground-based astronomy are reported. Advanced systems for the Deep Space Network and its Ground-Communications Facility are discussed including station control and system technology. Network sustaining as well as data and information systems are covered. Studies of geodynamics, investigations of the microwave spectrum, and the search for extraterrestrial intelligence are reported.

Middle School Science Teachers' Confidence and Pedagogical Practice of New Literacies

ERIC Educational Resources Information Center

Hsu, Hui-Yin; Wang, Shiang-Kwei; Runco, Lisa

2013-01-01

Due to the rapid advancements of information and communication technologies (ICTs), educational researchers argue that multimodal and new literacies should become common practices in schools. As new ICTs emerge and evolve, students need the new literacies skills and practices to successfully participate fully in the civic life of a global…

Digital Stories: Bringing Multimodal Texts to the Spanish Writing Classroom

ERIC Educational Resources Information Center

Oskoz, Ana; Elola, Idoia

2016-01-01

Despite the availability and growing use of digital story software for authoring and instructional purposes, little is known about learners' perceptions on its integration in the foreign language writing class. Following both a social semiotics approach and activity theory, this study focuses on six advanced Spanish learners' perceptions about the…

Reconfigurable Transceiver and Software-Defined Radio Architecture and Technology Evaluated for NASA Space Communications

NASA Technical Reports Server (NTRS)

Reinhart, Richard C.; Kacpura, Thomas J.

2004-01-01

The NASA Glenn Research Center is investigating the development and suitability of a software-based open-architecture for space-based reconfigurable transceivers (RTs) and software-defined radios (SDRs). The main objectives of this project are to enable advanced operations and reduce mission costs. SDRs are becoming more common because of the capabilities of reconfigurable digital signal processing technologies such as field programmable gate arrays and digital signal processors, which place radio functions in firmware and software that were traditionally performed with analog hardware components. Features of interest of this communications architecture include nonproprietary open standards and application programming interfaces to enable software reuse and portability, independent hardware and software development, and hardware and software functional separation. The goals for RT and SDR technologies for NASA space missions include prelaunch and on-orbit frequency and waveform reconfigurability and programmability, high data rate capability, and overall communications and processing flexibility. These operational advances over current state-of-art transceivers will be provided to reduce the power, mass, and cost of RTs and SDRs for space communications. The open architecture for NASA communications will support existing (legacy) communications needs and capabilities while providing a path to more capable, advanced waveform development and mission concepts (e.g., ad hoc constellations with self-healing networks and high-rate science data return). A study was completed to assess the state of the art in RT architectures, implementations, and technologies. In-house researchers conducted literature searches and analysis, interviewed Government and industry contacts, and solicited information and white papers from industry on space-qualifiable RTs and SDRs and their associated technologies for space-based NASA applications. The white papers were evaluated, compiled, and used to assess RT and SDR system architectures and core technology elements to determine an appropriate investment strategy to advance these technologies to meet future mission needs. The use of these radios in the space environment represents a challenge because of the space radiation suitability of the components, which drastically reduces the processing capability. The radios available for space are considered to be RTs (as opposed to SDRs), which are digitally programmable radios with selectable changes from an architecture combining analog and digital components. The limited flexibility of this design contrasts against the desire to have a power-efficient solution and open architecture.

Deep Space Network Radiometric Remote Sensing Program

NASA Technical Reports Server (NTRS)

Walter, Steven J.

1994-01-01

Planetary spacecraft are viewed through a troposphere that absorbs and delays radio signals propagating through it. Tropospheric water, in the form of vapor, cloud liquid, and precipitation, emits radio noise which limits satellite telemetry communication link performance. Even at X-band, rain storms have severely affected several satellite experiments including a planetary encounter. The problem will worsen with DSN implementation of Ka-band because communication link budgets will be dominated by tropospheric conditions. Troposphere-induced propagation delays currently limit VLBI accuracy and are significant sources of error for Doppler tracking. Additionally, the success of radio science programs such as satellite gravity wave experiments and atmospheric occultation experiments depends on minimizing the effect of water vapor-induced propagation delays. In order to overcome limitations imposed by the troposphere, the Deep Space Network has supported a program of radiometric remote sensing. Currently, water vapor radiometers (WVRs) and microwave temperature profilers (MTPs) support many aspects of the Deep Space Network operations and research and development programs. Their capability to sense atmospheric water, microwave sky brightness, and atmospheric temperature is critical to development of Ka-band telemetry systems, communication link models, VLBI, satellite gravity wave experiments, and radio science missions. During 1993, WVRs provided data for propagation model development, supported planetary missions, and demonstrated advanced tracking capability. Collection of atmospheric statistics is necessary to model and predict performance of Ka-band telemetry links, antenna arrays, and radio science experiments. Since the spectrum of weather variations has power at very long time scales, atmospheric measurements have been requested for periods ranging from one year to a decade at each DSN site. The resulting database would provide reliable statistics on daily, monthly, and seasonal variations. Only long-term monitoring will prevent biases from being introduced by an exceptionally wet or dry year. Support for planetary missions included tropospheric calibration for the recent Mars Observer gravity wave experiments and Ka-band link experiment (KaBLE). Additionally, several proposed radio science experiments such as profiling planetary atmospheres using satellite occultations and Ka-band gravitational wave searches require advanced radiometer technology development. Finally, there has been a consistent advanced technology program to advance satellite navigational and tracking capabilities. This year that included an experiment with radiometer based tropospheric calibration for a series of VLBI catalog measurements.

Solar-geophysical data number 499, March 1986. Part 1: (Prompt reports). Data for February 1986, January 1986 and late data

NASA Technical Reports Server (NTRS)

Coffey, H. E. (Editor)

1986-01-01

Solar-Geophysical Data Number 499, March 1986, Part 1 (Prompt Reports); Data for February 1986, January 1986 and Late Data, contains the following: Detailed index for 1985 to 1986; Data for February 1986--(IUWDS alert periods (Advance and worldwide), Solar activity indices, Solar flares, Solar radio emission, Vostok inferred interplanetary magnetic field polarity, Stanford mean solar magnetic field); data for January 1986--(Solar active regions, Sudden ionospheric disturbances, Solar radio spectral observations, Cosmic ray measurements by neutron monitor, Geomagnetic indices, Radio propagation indices); Late data-(Solar active regions, Solar radio spectral observations Culgoora, Cosmic ray measurements by neutron monitor, Calcium plage data).

6.3 MeV fast neutrons in the treatment of patients with locally advanced and locally recurrent breast cancer

NASA Astrophysics Data System (ADS)

Velikaya, V. V.; Musabaeva, L. I.; Lisin, V. A.; Startseva, Zh. A.

2016-08-01

The study included 135 breast cancer patients (70 patients with locally recurrent breast cancer and 65 patients with locally advanced breast cancer with unfavorable prognostic factors) who received the neutron therapy alone or in combination with the photon therapy. The neutron therapy was shown to be effective in multimodality treatment of patients with locally advanced and locally recurrent breast cancer. The 8-year survival rate in patients without repeated breast cancer recurrence was 87.6 ± 8.7% after the neutron and neutron-photon therapy and 54.3 ± 9.2% after the electron beam therapy.

6.3 MeV fast neutrons in the treatment of patients with locally advanced and locally recurrent breast cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Velikaya, V. V., E-mail: viktoria.v.v@inbox.ru; Startseva, Zh. A., E-mail: zhanna.alex@rambler.ru; National Research Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, 634050

The study included 135 breast cancer patients (70 patients with locally recurrent breast cancer and 65 patients with locally advanced breast cancer with unfavorable prognostic factors) who received the neutron therapy alone or in combination with the photon therapy. The neutron therapy was shown to be effective in multimodality treatment of patients with locally advanced and locally recurrent breast cancer. The 8-year survival rate in patients without repeated breast cancer recurrence was 87.6 ± 8.7% after the neutron and neutron-photon therapy and 54.3 ± 9.2% after the electron beam therapy.

Reconfigurable, Intelligently-Adaptive, Communication System, an SDR Platform

NASA Technical Reports Server (NTRS)

Roche, Rigoberto J.; Shalkhauser, Mary Jo; Hickey, Joseph P.; Briones, Janette C.

2016-01-01

The Space Telecommunications Radio System (STRS) provides a common, consistent framework to abstract the application software from the radio platform hardware. STRS aims to reduce the cost and risk of using complex, configurable and reprogrammable radio systems across NASA missions. The NASA Glenn Research Center (GRC) team made a software defined radio (SDR) platform STRS compliant by adding an STRS operating environment and a field programmable gate array (FPGA) wrapper, capable of implementing each of the platforms interfaces, as well as a test waveform to exercise those interfaces. This effort serves to provide a framework toward waveform development onto an STRS compliant platform to support future space communication systems for advanced exploration missions. The use of validated STRS compliant applications provides tested code with extensive documentation to potentially reduce risk, cost and e ort in development of space-deployable SDRs. This paper discusses the advantages of STRS, the integration of STRS onto a Reconfigurable, Intelligently-Adaptive, Communication System (RIACS) SDR platform, and the test waveform and wrapper development e orts. The paper emphasizes the infusion of the STRS Architecture onto the RIACS platform for potential use in next generation flight system SDRs for advanced exploration missions.

Comparing two lower-dose cisplatin programs for radio-chemotherapy of locally advanced head-and-neck cancers.

PubMed

Rades, Dirk; Seidl, Daniel; Janssen, Stefan; Strojan, Primoz; Karner, Katarina; Bajrovic, Amira; Hakim, Samer G; Wollenberg, Barbara; Schild, Steven E

2017-02-01

Radio-chemotherapy is a common treatment for locally advanced squamous cell head-and-neck cancers (LA-SCCHN). Cisplatin (100 mg/m 2 ) every 3 weeks is very common but associated with considerable toxicity. Therefore, cisplatin programs with lower daily doses were introduced. There is a lack of studies comparing lower-dose programs. In this study, 85 patients receiving radio-chemotherapy with 20 mg/m 2 cisplatin on 5 days every 4 weeks (group A) were retrospectively compared to 85 patients receiving radio-chemotherapy with 30-40 mg/m 2 cisplatin weekly (group B). Groups were matched for nine factors including age, gender, performance score, tumor site, T-/N-category, surgery, hemoglobin before radio-chemotherapy, and radiation technique. One- and 3-year loco-regional control rates were 83 and 69 % in group A versus 74 and 63 % in group B (p = 0.12). One- and 3-year survival rates were 93 % and 73 % in group A versus 91 and 49 % in group B (p = 0.011). On multivariate analysis, survival was significantly better for group A (HR 1.17; p = 0.002). In groups A and B, 12 and 28 % of patients, respectively, did not receive a cumulative cisplatin dose ≥180 mg/m 2 (p = 0.016). Toxicity rates were not significantly different. On subgroup analyses, group A patients had better loco-regional control (p = 0.040) and survival (p = 0.005) than group B patients after definitive radio-chemotherapy. In patients receiving adjuvant radio-chemotherapy, outcomes were not significantly different. Thus, 20 mg/m 2 cisplatin on 5 days every 4 weeks resulted in better loco-regional control and survival in patients receiving definitive radio-chemotherapy and may be preferable for these patients. Confirmation of these results in a randomized trial is warranted.

SETI reloaded: Next generation radio telescopes, transients and cognitive computing

NASA Astrophysics Data System (ADS)

Garrett, Michael A.

2015-08-01

The Search for Extra-terrestrial Intelligence (SETI) using radio telescopes is an area of research that is now more than 50 years old. Thus far, both targeted and wide-area surveys have yet to detect artificial signals from intelligent civilisations. In this paper, I argue that the incidence of co-existing intelligent and communicating civilisations is probably small in the Milky Way. While this makes successful SETI searches a very difficult pursuit indeed, the huge impact of even a single detection requires us to continue the search. A substantial increase in the overall performance of radio telescopes (and in particular future wide-field instruments such as the Square Kilometre Array - SKA), provide renewed optimism in the field. Evidence for this is already to be seen in the success of SETI researchers in acquiring observations on some of the world's most sensitive radio telescope facilities via open, peer-reviewed processes. The increasing interest in the dynamic radio sky, and our ability to detect new and rapid transient phenomena such as Fast Radio Bursts (FRB) is also greatly encouraging. While the nature of FRBs is not yet fully understood, I argue they are unlikely to be the signature of distant extra-terrestrial civilisations. As astronomers face a data avalanche on all sides, advances made in related areas such as advanced Big Data analytics, and cognitive computing are crucial to enable serendipitous discoveries to be made. In any case, as the era of the SKA fast approaches, the prospects of a SETI detection have never been better.

An inductorless multi-mode RF front end for GNSS receiver in 55 nm CMOS

NASA Astrophysics Data System (ADS)

Yanbin, Luo; Chengyan, Ma; Yebing, Gan; Min, Qian; Tianchun, Ye

2015-10-01

An inductorless multi-mode RF front end for a global navigation satellite system (GNSS) receiver is presented. Unlike the traditional topology of a low noise amplifier (LNA), the inductorless current-mode noise-canceling LNA is applied in this design. The high-impedance-input radio frequency amplifier (RFA) further amplifies the GNSS signals and changes the single-end signal path into fully differential. The passive mixer down-converts the signals to the intermediate frequency (IF) band and conveys the signals to the analogue blocks. The local oscillator (LO) buffer divides the output frequency of the voltage controlled oscillator (VCO) and generates 25%-duty-cycle quadrature square waves to drive the mixer. Our measurement results display that the implemented RF front end achieves good overall performance while consuming only 6.7 mA from 1.2 V supply. The input return loss is better than -26 dB and the ultra low noise figure of 1.43 dB leads to high sensitivity of the GNSS receiver. The input 1 dB compression point is -43 dBm at the high gain of 48 dB. The designed circuit is fabricated in 55 nm CMOS technology and the die area, which is much smaller than traditional circuit, is around 220 × 280 μm2.

Using Videos and Multimodal Discourse Analysis to Study How Students Learn a Trade

ERIC Educational Resources Information Center

Chan, Selena

2013-01-01

The use of video to assist with ethnographical-based research is not a new phenomenon. Recent advances in technology have reduced the costs and technical expertise required to use videos for gathering research data. Audio-visual records of learning activities as they take place, allow for many non-vocal and inter-personal communication…

Raising Students' Awareness of the Implications of Multimodality for Content Design and Usability: The Web Site Project

ERIC Educational Resources Information Center

Planken, Brigitte; Kreps, Arnold J.

2006-01-01

As advances in information communication technology have continued to affect business communication, the challenge for teachers over the past decade has been to stay abreast of new developments by integrating into the curriculum current theoretical and practice-based perspectives that can inform their students how to effectively create, manage,…

Emotional Design Tutoring System Based on Multimodal Affective Computing Techniques

ERIC Educational Resources Information Center

Wang, Cheng-Hung; Lin, Hao-Chiang Koong

2018-01-01

In a traditional class, the role of the teacher is to teach and that of the students is to learn. However, the constant and rapid technological advancements have transformed education in numerous ways. For instance, in addition to traditional, face to face teaching, E-learning is now possible. Nevertheless, face to face teaching is unavailable in…

Distributed control network for optogenetic experiments

NASA Astrophysics Data System (ADS)

Kasprowicz, G.; Juszczyk, B.; Mankiewicz, L.

2014-11-01

Nowadays optogenetic experiments are constructed to examine social behavioural relations in groups of animals. A novel concept of implantable device with distributed control network and advanced positioning capabilities is proposed. It is based on wireless energy transfer technology, micro-power radio interface and advanced signal processing.

WE-H-206-02: Recent Advances in Multi-Modality Molecular Imaging of Small Animals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tsui, B.

Lihong V. Wang: Photoacoustic tomography (PAT), combining non-ionizing optical and ultrasonic waves via the photoacoustic effect, provides in vivo multiscale functional, metabolic, and molecular imaging. Broad applications include imaging of the breast, brain, skin, esophagus, colon, vascular system, and lymphatic system in humans or animals. Light offers rich contrast but does not penetrate biological tissue in straight paths as x-rays do. Consequently, high-resolution pure optical imaging (e.g., confocal microscopy, two-photon microscopy, and optical coherence tomography) is limited to penetration within the optical diffusion limit (∼1 mm in the skin). Ultrasonic imaging, on the contrary, provides fine spatial resolution but suffersmore » from both poor contrast in early-stage tumors and strong speckle artifacts. In PAT, pulsed laser light penetrates tissue and generates a small but rapid temperature rise, which induces emission of ultrasonic waves due to thermoelastic expansion. The ultrasonic waves, orders of magnitude less scattering than optical waves, are then detected to form high-resolution images of optical absorption at depths up to 7 cm, conquering the optical diffusion limit. PAT is the only modality capable of imaging across the length scales of organelles, cells, tissues, and organs (up to whole-body small animals) with consistent contrast. This rapidly growing technology promises to enable multiscale biological research and accelerate translation from microscopic laboratory discoveries to macroscopic clinical practice. PAT may also hold the key to label-free early detection of cancer by in vivo quantification of hypermetabolism, the quintessential hallmark of malignancy. Learning Objectives: To understand the contrast mechanism of PAT To understand the multiscale applications of PAT Benjamin M. W. Tsui: Multi-modality molecular imaging instrumentation and techniques have been major developments in small animal imaging that has contributed significantly to biomedical research during the past decade. The initial development was an extension of clinical PET/CT and SPECT/CT from human to small animals and combine the unique functional information obtained from PET and SPECT with anatomical information provided by the CT in registered multi-modality images. The requirements to image a mouse whose size is an order of magnitude smaller than that of a human have spurred advances in new radiation detector technologies, novel imaging system designs and special image reconstruction and processing techniques. Examples are new detector materials and designs with high intrinsic resolution, multi-pinhole (MPH) collimator design for much improved resolution and detection efficiency compared to the conventional collimator designs in SPECT, 3D high-resolution and artifact-free MPH and sparse-view image reconstruction techniques, and iterative image reconstruction methods with system response modeling for resolution recovery and image noise reduction for much improved image quality. The spatial resolution of PET and SPECT has improved from ∼6–12 mm to ∼1 mm a few years ago to sub-millimeter today. A recent commercial small animal SPECT system has achieved a resolution of ∼0.25 mm which surpasses that of a state-of-art PET system whose resolution is limited by the positron range. More recently, multimodality SA PET/MRI and SPECT/MRI systems have been developed in research laboratories. Also, multi-modality SA imaging systems that include other imaging modalities such as optical and ultrasound are being actively pursued. In this presentation, we will provide a review of the development, recent advances and future outlook of multi-modality molecular imaging of small animals. Learning Objectives: To learn about the two major multi-modality molecular imaging techniques of small animals. To learn about the spatial resolution achievable by the molecular imaging systems for small animal today. To learn about the new multi-modality imaging instrumentation and techniques that are being developed. Sang Hyun Cho; X-ray fluorescence (XRF) imaging, such as x-ray fluorescence computed tomography (XFCT), offers unique capabilities for accurate identification and quantification of metals within the imaging objects. As a result, it has emerged as a promising quantitative imaging modality in recent years, especially in conjunction with metal-based imaging probes. This talk will familiarize the audience with the basic principles of XRF/XFCT imaging. It will also cover the latest development of benchtop XFCT technology. Additionally, the use of metallic nanoparticles such as gold nanoparticles, in conjunction with benchtop XFCT, will be discussed within the context of preclinical multimodal multiplexed molecular imaging. Learning Objectives: To learn the basic principles of XRF/XFCT imaging To learn the latest advances in benchtop XFCT development for preclinical imaging Funding support received from NIH and DOD; Funding support received from GE Healthcare; Funding support received from Siemens AX; Patent royalties received from GE Healthcare; L. Wang, Funding Support: NIH; COI: Microphotoacoustics; S. Cho, Yes: ;NIH/NCI grant R01CA155446 DOD/PCRP grant W81XWH-12-1-0198.« less

Enabling Planetary Geodesy With the Deep Space Network

NASA Astrophysics Data System (ADS)

Park, R. S.; Asmar, S. W.; Armstrong, J. W.; Buccino, D.; Folkner, W. M.; Iess, L.; Konopliv, A. S.; Lazio, J.

2015-12-01

For five decades of planetary exploration, missions have carried out Radio Science experiments that led to numerous discoveries in planetary geodesy. The interior structures of many planets, large moons, asteroids and comet nuclei have been modeled based on their gravitational fields and dynamical parameters derived from precision Doppler and range measurements, often called radio metrics. Advanced instrumentation has resulted in the high level of data quality that enabled scientific breakthroughs. This instrumentation scheme, however, is distributed between elements on the spacecraft and others at the stations of the Deep Space Network (DSN), making the DSN a world-class science instrument. The design and performance of the DSN stations directly determines the quality of the science observables and radio link-based planetary geodesy observations are established by methodologies and capabilities of the DSN. In this paper, we summarize major recent discoveries in planetary geodesy at the rocky planets and the Moon, Saturnian and Jovian satellites, Phobos, and Vesta; experiments and analysis in progress at Ceres and Pluto; upcoming experiments at Jupiter, Saturn and Mars (InSight), and the long-term outlook for approved future missions with geodesy objectives. The DSN's role will be described along the technical advancements in DSN transmitters, receivers, atomic clocks, and other specialized instrumentation, such as the Advanced Water Vapor Radiometer, Advanced Ranging Instrument, as well as relevant mechanical and electrical components. Advanced techniques for calibrations of known noise sources and Earth's troposphere, ionosphere, and interplanetary plasma are also presented. A typical error budget will be presented to aid future investigations in carrying out trade-off studies in the end-to-end system performance.

Multiradio Resource Management: Parallel Transmission for Higher Throughput?

NASA Astrophysics Data System (ADS)

Bazzi, Alessandro; Pasolini, Gianni; Andrisano, Oreste

2008-12-01

Mobile communication systems beyond the third generation will see the interconnection of heterogeneous radio access networks (UMTS, WiMax, wireless local area networks, etc.) in order to always provide the best quality of service (QoS) to users with multimode terminals. This scenario poses a number of critical issues, which have to be faced in order to get the best from the integrated access network. In this paper, we will investigate the issue of parallel transmission over multiple radio access technologies (RATs), focusing the attention on the QoS perceived by final users. We will show that the achievement of a real benefit from parallel transmission over multiple RATs is conditioned to the fulfilment of some requirements related to the kind of RATs, the multiradio resource management (MRRM) strategy, and the transport-level protocol behaviour. All these aspects will be carefully considered in our investigation, which will be carried out partly adopting an analytical approach and partly by means of simulations. In this paper, in particular, we will propose a simple but effective MRRM algorithm, whose performance will be investigated in IEEE802.11a-UMTS and IEEE802.11a-IEEE802.16e heterogeneous networks (adopted as case studies).

Echocardiography in the Era of Multimodality Cardiovascular Imaging

PubMed Central

Shah, Benoy Nalin

2013-01-01

Echocardiography remains the most frequently performed cardiac imaging investigation and is an invaluable tool for detailed and accurate evaluation of cardiac structure and function. Echocardiography, nuclear cardiology, cardiac magnetic resonance imaging, and cardiovascular-computed tomography comprise the subspeciality of cardiovascular imaging, and these techniques are often used together for a multimodality, comprehensive assessment of a number of cardiac diseases. This paper provides the general cardiologist and physician with an overview of state-of-the-art modern echocardiography, summarising established indications as well as highlighting advances in stress echocardiography, three-dimensional echocardiography, deformation imaging, and contrast echocardiography. Strengths and limitations of echocardiography are discussed as well as the growing role of real-time three-dimensional echocardiography in the guidance of structural heart interventions in the cardiac catheter laboratory. PMID:23878804

Magnetic Nanoparticles for Multi-Imaging and Drug Delivery

PubMed Central

Lee, Jae-Hyun; Kim, Ji-wook; Cheon, Jinwoo

2013-01-01

Various bio-medical applications of magnetic nanoparticles have been explored during the past few decades. As tools that hold great potential for advancing biological sciences, magnetic nanoparticles have been used as platform materials for enhanced magnetic resonance imaging (MRI) agents, biological separation and magnetic drug delivery systems, and magnetic hyperthermia treatment. Furthermore, approaches that integrate various imaging and bioactive moieties have been used in the design of multi-modality systems, which possess synergistically enhanced properties such as better imaging resolution and sensitivity, molecular recognition capabilities, stimulus responsive drug delivery with on-demand control, and spatio-temporally controlled cell signal activation. Below, recent studies that focus on the design and synthesis of multi-mode magnetic nanoparticles will be briefly reviewed and their potential applications in the imaging and therapy areas will be also discussed. PMID:23579479

Analysis of the Capability and Limitations of Relativistic Gravity Measurements Using Radio Astronomy Methods

NASA Technical Reports Server (NTRS)

Shapiro, I. I.; Counselman, C. C., III

1975-01-01

The uses of radar observations of planets and very-long-baseline radio interferometric observations of extragalactic objects to test theories of gravitation are described in detail with special emphasis on sources of error. The accuracy achievable in these tests with data already obtained, can be summarized in terms of: retardation of signal propagation (radar), deflection of radio waves (interferometry), advance of planetary perihelia (radar), gravitational quadrupole moment of sun (radar), and time variation of gravitational constant (radar). The analyses completed to date have yielded no significant disagreement with the predictions of general relativity.

Galaxy-wide radio-induced feedback in a radio-quiet quasar

NASA Astrophysics Data System (ADS)

Villar-Martín, M.; Emonts, B.; Cabrera Lavers, A.; Tadhunter, C.; Mukherjee, D.; Humphrey, A.; Rodríguez Zaurín, J.; Ramos Almeida, C.; Pérez Torres, M.; Bessiere, P.

2017-12-01

We report the discovery of a radio-quiet type 2 quasar (SDSS J165315.06+234943.0 nicknamed the 'Beetle' at z = 0.103) with unambiguous evidence for active galactic nucleus (AGN) radio-induced feedback acting across a total extension of ∼46 kpc and up to ∼26 kpc from the AGN. To the best of our knowledge, this is the first radio-quiet system where radio-induced feedback has been securely identified at ≫several kpc from the AGN. The morphological, ionization and kinematic properties of the extended ionized gas are correlated with the radio structures. We find along the radio axis (a) enhancement of the optical line emission at the location of the radio hotspots (b) turbulent gas kinematics (FWHM ∼ 380-470 km s-1) across the entire spatial range circumscribed by them (c) ionization minima for the turbulent gas at the location of the hot spots, (d) high temperature Te ≳ 1.9 × 104 K at the NE hotspot. Turbulent gas is also found far from the radio axis, ∼25 kpc in the perpendicular direction. We propose a scenario in which the radio structures have perforated the interstellar medium of the galaxy and escaped into the circumgalactic medium. While advancing, they have interacted with in situ gas modifying its properties. Our results show that jets of modest power can be the dominant feedback mechanism acting across huge volumes in radio-quiet systems, including highly accreting luminous AGNs, where radiative mode feedback may be expected.

A Constant Envelope OFDM Implementation on GNU Radio

DTIC Science & Technology

2015-02-02

more advanced schemes like Decision Feedback Equalization or Turbo Equalization must be implemented to avoid the noise enhancement that all linear...block is coded in C++, and uses the phase unwrapping algorithm similar to MATLABs unwrap() function. To avoid false wraps propagating throughout the...outperform the real-time GNU radio implementation at higher SNR’s. While the unequalized experiment with the Matlab processor usually stayed within 5

An Analysis of the Defense Acquisition Strategy for Unmanned Systems

DTIC Science & Technology

2014-03-01

product service code RAA Rapid Acquisition Authority RCS radar cross section REF Rapid Equipping Force RFID radio frequency identification RDT...commercialization of the radio frequency identification (RFID) chip also provides a useful basis for comparison. WWII served as the proving ground for RFID...companies following the September 11 , 2001 attacks. It is important to note that despite advances in GPS technology and long-range communications

Advanced Image Processing Techniques for Maximum Information Recovery

DTIC Science & Technology

2006-11-01

0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision...available information from an image. Some radio frequency and optical sensors collect large-scale sets of spatial imagery data whose content is often...Some radio frequency and optical sensors collect large- scale sets of spatial imagery data whose content is often obscured by fog, clouds, foliage

Novel technologies and theoretical models in radiation therapy of cancer patients using 6.3 MeV fast neutrons produced by U-120 cyclotron

DOE Office of Scientific and Technical Information (OSTI.GOV)

Musabaeva, L. I., E-mail: musabaevaLI@oncology.tomsk.ru; Lisin, V. A., E-mail: Lisin@oncology.tomsk.ru; Startseva, Zh. A., E-mail: zhanna.alex@rambler.ru

The analysis of clinical use of neutron therapy with 6 MeV fast neutrons compared to conventional radiation therapy was carried out. The experience of using neutron and mixed neutron and photon therapy in patients with different radio-resistant malignant tumors shows the necessity of further studies and development of the novel approaches to densely-ionizing radiation. The results of dosimetry and radiobiological studies have been the basis for planning clinical programs for neutron therapy. Clinical trials over the past 30 years have shown that neutron therapy successfully destroys radio-resistant cancers, including salivary gland tumors, adenoidcystic carcinoma, inoperable sarcomas, locally advanced head andmore » neck tumors, and locally advanced prostate cancer. Radiation therapy with 6.3 MeV fast neutrons used alone and in combination with photon therapy resulted in improved long-term treatment outcomes in patients with radio-resistant malignant tumors.« less

Relativistic and Slowing Down: The Flow in the Hotspots of Powerful Radio Galaxies and Quasars

NASA Technical Reports Server (NTRS)

Kazanas, D.

2003-01-01

The 'hotspots' of powerful radio galaxies (the compact, high brightness regions, where the jet flow collides with the intergalactic medium (IGM)) have been imaged in radio, optical and recently in X-ray frequencies. We propose a scheme that unifies their, at first sight, disparate broad band (radio to X-ray) spectral properties. This scheme involves a relativistic flow upstream of the hotspot that decelerates to the sub-relativistic speed of its inferred advance through the IGM and it is viewed at different angles to its direction of motion, as suggested by two independent orientation estimators (the presence or not of broad emission lines in their optical spectra and the core-to-extended radio luminosity). This scheme, besides providing an account of the hotspot spectral properties with jet orientation, it also suggests that the large-scale jets remain relativistic all the way to the hotspots.

Best-Ever Snapshot of a Black Hole's Jets

NASA Image and Video Library

2017-12-08

NASA image release May 20, 2011 To see a really cool video related to this image go here: www.flickr.com/photos/gsfc/5740451675/in/photostream The giant elliptical galaxy NGC 5128 is the radio source known as Centaurus A. Vast radio-emitting lobes (shown as orange in this optical/radio composite) extend nearly a million light-years from the galaxy. Credit: Capella Observatory (optical), with radio data from Ilana Feain, Tim Cornwell, and Ron Ekers (CSIRO/ATNF), R. Morganti (ASTRON), and N. Junkes (MPIfR). To read more go to: www.nasa.gov/topics/universe/features/radio-particle-jets... NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Join us on Facebook

Radioelectronics and space exploration

NASA Astrophysics Data System (ADS)

Sarafanov, T.; Bogoroditskiy, Y.; Milyukov, I.

1985-03-01

Citing the 23 years since Yuriy Gagarin's first radio transmission from outer space, the developments in radio communications and their role in mission control are summarized. Use of satellites for radio and television links with ground stations are an important part of information exchange. Construction and preventive maintenance activities by Soviet cosmonauts, use of radio technology for docking procedures and the reliability of such equipment, and the growing role of computer technology in space vehicles with human crews and pilotless craft are discussed. Automatic interplanetary vehicles that have landed on the moon, Mars and Venus, as well as artificial earth satellites, are facilitating weather and communication advances. Mock space equipment using radio and computer technology is of great importance for training cosmonauts. Despite all these practical applications, optimum utilization of automated equipment has yet to be achieved, and offers further challenge to Soviet and other engineers and technicians.

Digital Beamforming Synthetic Aperture Radar Developments at NASA Goddard Space Flight Center

NASA Technical Reports Server (NTRS)

Rincon, Rafael; Fatoyinbo, Temilola; Osmanoglu, Batuhan; Lee, Seung Kuk; Du Toit, Cornelis F.; Perrine, Martin; Ranson, K. Jon; Sun, Guoqing; Deshpande, Manohar; Beck, Jaclyn;

Radio Searches for Signatures of Advanced Extraterrestrial Life

NASA Astrophysics Data System (ADS)

Siemion, Andrew

Over the last several decades, observational astronomy has produced a flood of discoveries that suggest that the building blocks and circumstances that gave rise to life on Earth may be the rule rather than the exception. It has now been conclusively shown that planets are common and that some 5-15% of FGKM stars host planets existing in their host star's habitable zone. Further, terrestrial biology has demonstrated that life on our own planet can thrive in extraordinarily extreme environments, dramatically extending our notion of what constitutes habitability. The deeper question, yet unanswered, is whether or not life in any form has ever existed in an environment outside of the Earth. As humans, we are drawn to an even more profound question, that of whether or not extraterrestrial life may have evolved a curiosity about the universe similar to our own and the technology with which to explore it. Radio astronomy has long played a prominent role in searches for extraterrestrial intelligence (SETI), beginning with the first suggestions by Cocconi and Morrison (1959) that narrow-band radio signals near 1420 MHz might be effective tracers of advanced technology and early experiments along these lines by Frank Drake in 1961, continuing through to more recent investigations searching for several types of coherent radio signals indicative of technology at a wider range of frequencies. The motivations for radio searches for extraterrestrial intelligence have been throughly discussed in the literature, but the salient arguments are the following: 1. coherent radio emission is commonly produced by advanced technology (judging by Earth’s technological development), 2. electromagnetic radiation can convey information at the maximum velocity currently known to be possible, 3. radio photons are energetically cheap to produce, 4. certain types of coherent radio emissions are easily distinguished from astrophysical background sources, especially within the so-called ``terrestrial microwave window'' and 5. these emissions can transit vast regions of interstellar space relatively unaffected by gas, plasma and dust. Our group is conducting a variety of radio SETI at a wide range of frequencies, from 50 MHz to 230 GHz, using several facilities: the Dutch/European Low-Frequency Array (LOFAR), Arecibo Observatory, the Green Bank Telescope and the Combined Array for Research in Millimeter-wave Astronomy (CARMA). Our experiments employ a variety of strategies, including searches of nearby stars, stars with known exoplanets and the galactic center. We have also developed an observing pipeline that targets systems of multiple exoplanets at epochs in which two or more planets are aligned relative to Earth, which we have dubbed exoplanetary interplanetary communication (EPIC) SETI. Our detection algorithms are sensitive to a wide range of signal types, and we have developed numerous radio interference rejection techniques. Many of our experiments operate ``commensally'' with other science projects, providing thousands of hours of observations with the largest telescopes in the world. Here we present the status of our radio SETI efforts, discuss observations conducted to-date and review the various regions of parameter space probed by each experiment.

Communication acoustics in Bell Labs

NASA Astrophysics Data System (ADS)

Flanagan, J. L.

2004-05-01

Communication aoustics has been a central theme in Bell Labs research since its inception. Telecommunication serves human information exchange. And, humans favor spoken language as a principal mode. The atmospheric medium typically provides the link between articulation and hearing. Creation, control and detection of sound, and the human's facility for generation and perception are basic ingredients of telecommunication. Electronics technology of the 1920s ushered in great advances in communication at a distance, a strong economical impetus being to overcome bandwidth limitations of wireline and cable. Early research established criteria for speech transmission with high quality and intelligibility. These insights supported exploration of means for efficient transmission-obtaining the greatest amount of speech information over a given bandwidth. Transoceanic communication was initiated by undersea cables for telegraphy. But these long cables exhibited very limited bandwidth (order of few hundred Hz). The challenge of sending voice across the oceans spawned perhaps the best known speech compression technique of history-the Vocoder, which parametrized the signal for transmission in about 300 Hz bandwidth, one-tenth that required for the typical waveform channel. Quality and intelligibility were grave issues (and they still are). At the same time parametric representation offered possibilities for encryption and privacy inside a traditional voice bandwidth. Confidential conversations between Roosevelt and Churchill during World War II were carried over high-frequency radio by an encrypted vocoder system known as Sigsaly. Major engineering advances in the late 1940s and early 1950s moved telecommunications into a new regime-digital technology. These key advances were at least three: (i) new understanding of time-discrete (sampled) representation of signals, (ii) digital computation (especially binary based), and (iii) evolving capabilities in microelectronics that ultimately provided circuits of enormous complexity with low cost and power. Digital transmission (as exemplified in pulse code modulation-PCM, and its many derivatives) became a telecommunication mainstay, along with switches to control and route information in digital form. Concomitantly, storage means for digital information advanced, providing another impetus for speech compression. More and more, humans saw the need to exchange speech information with machines, as well as with other humans. Human-machine speech communication came to full stride in the early 1990s, and now has expanded to multimodal domains that begin to support enhanced naturalness, using contemporaneous sight, sound and touch signaling. Packet transmission is supplanting circuit switching, and voice and video are commonly being carried by Internet protocol.

Adjuvant neutron therapy in complex treatment of patients with locally advanced breast cancer

NASA Astrophysics Data System (ADS)

Lisin, V. A.; Velikaya, V. V.; Startseva, Zh. A.; Popova, N. O.; Goldberg, V. E.

2017-09-01

The study included 128 patients with stage T2-4N0-3M0 locally advanced breast cancer. All patients were divided into two groups. Group I (study group) consisted of 68 patients, who received neutron therapy, and group II (control group) comprised 60 patients, who received electron beam therapy. Neutron therapy was well tolerated by the patients and 1-2 grade radiation skin reactions were the most common. Neutron therapy was shown to be effective in multimodality treatment of the patients with locally advanced breast cancer. The 8-year recurrence-free survival rate in the patients with locally advanced breast cancer was 94.5 ± 4.1% after neutron therapy and 81.4 ± 5.9% after electron beam therapy (p = 0.05).

75 FR 35989 - Facilitating the Provision of Fixed and Mobile Broadband Access, Educational and Other Advanced...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-24

...] Facilitating the Provision of Fixed and Mobile Broadband Access, Educational and Other Advanced Services in the...), clarifying the requirements necessary for Broadband Radio Service (BRS) and Educational Broadband Service (EBS) licensees to demonstrate substantial service and ensure that BRS licensees of new initial...

A User-Configurable Headstage for Multimodality Neuromonitoring in Freely Moving Rats

PubMed Central

Limnuson, Kanokwan; Narayan, Raj K.; Chiluwal, Amrit; Golanov, Eugene V.; Bouton, Chad E.; Li, Chunyan

2016-01-01

Multimodal monitoring of brain activity, physiology, and neurochemistry is an important approach to gain insight into brain function, modulation, and pathology. With recent progress in micro- and nanotechnology, micro-nano-implants have become important catalysts in advancing brain research. However, to date, only a limited number of brain parameters have been measured simultaneously in awake animals in spite of significant recent progress in sensor technology. Here we have provided a cost and time effective approach to designing a headstage to conduct a multimodality brain monitoring in freely moving animals. To demonstrate this method, we have designed a user-configurable headstage for our micromachined multimodal neural probe. The headstage can reliably record direct-current electrocorticography (DC-ECoG), brain oxygen tension (PbrO2), cortical temperature, and regional cerebral blood flow (rCBF) simultaneously without significant signal crosstalk or movement artifacts for 72 h. Even in a noisy environment, it can record low-level neural signals with high quality. Moreover, it can easily interface with signal conditioning circuits that have high power consumption and are difficult to miniaturize. To the best of our knowledge, this is the first time where multiple physiological, biochemical, and electrophysiological cerebral variables have been simultaneously recorded from freely moving rats. We anticipate that the developed system will aid in gaining further insight into not only normal cerebral functioning but also pathophysiology of conditions such as epilepsy, stroke, and traumatic brain injury. PMID:27594826

Radio Counterparts of Compact Binary Mergers Detectable in Gravitational Waves: A Simulation for an Optimized Survey

NASA Astrophysics Data System (ADS)

Hotokezaka, K.; Nissanke, S.; Hallinan, G.; Lazio, T. J. W.; Nakar, E.; Piran, T.

2016-11-01

Mergers of binary neutron stars and black hole-neutron star binaries produce gravitational-wave (GW) emission and outflows with significant kinetic energies. These outflows result in radio emissions through synchrotron radiation. We explore the detectability of these synchrotron-generated radio signals by follow-up observations of GW merger events lacking a detection of electromagnetic counterparts in other wavelengths. We model radio light curves arising from (I) sub-relativistic merger ejecta and (II) ultra-relativistic jets. The former produce radio remnants on timescales of a few years and the latter produce γ-ray bursts in the direction of the jet and orphan-radio afterglows extending over wider angles on timescales of weeks. Based on the derived light curves, we suggest an optimized survey at 1.4 GHz with five epochs separated by a logarithmic time interval. We estimate the detectability of the radio counterparts of simulated GW-merger events to be detected by advanced LIGO and Virgo by current and future radio facilities. The detectable distances for these GW merger events could be as high as 1 Gpc. Around 20%-60% of the long-lasting radio remnants will be detectable in the case of the moderate kinetic energy of 3\\cdot {10}50 erg and a circum-merger density of 0.1 {{cm}}-3 or larger, while 5%-20% of the orphan-radio afterglows with kinetic energy of 1048 erg will be detectable. The detection likelihood increases if one focuses on the well-localizable GW events. We discuss the background noise due to radio fluxes of host galaxies and false positives arising from extragalactic radio transients and variable active galactic nuclei, and we show that the quiet radio transient sky is of great advantage when searching for the radio counterparts.

ACSPRI 2014 4th International Social Science Methodology Conference Report

DTIC Science & Technology

2015-04-01

Validity, trustworthiness and rigour: quality and the idea of qualitative research . Journal of Advanced Nursing, 304-310. Spencer, L., Ritchie, J...increasing data quality; the Total Survey Error framework; multi-modal on-line surveying, quality frameworks for assessing qualitative research ; and...provided an overview of the current perspectives on causal claims in qualitative research . Three approaches to generating plausible causal

Gold nanoprobes for theranostics

PubMed Central

Panchapakesan, Balaji; Book-Newell, Brittany; Sethu, Palaniappan; Rao, Madhusudhana; Irudayaraj, Joseph

2011-01-01

Gold nanoprobes have become attractive diagnostic and therapeutic agents in medicine and life sciences research owing to their reproducible synthesis with atomic level precision, unique physical and chemical properties, versatility of their morphologies, flexibility in functionalization, ease of targeting, efficiency in drug delivery and opportunities for multimodal therapy. This review highlights some of the recent advances and the potential for gold nanoprobes in theranostics. PMID:22122586

Multimodality Imaging in Cardiac Sarcoidosis: Is There a Winner?

PubMed Central

Perez, Irving E.; Garcia, Mario J.; Taub, Cynthia C.

2016-01-01

Sarcoidosis is a multisystem granulomatous disease of unknown cause that can affect the heart. Cardiac sarcoidosis may be present in as many as 25% of patients with systemic sarcoidosis, and it is frequently underdiagnosed. The early and accurate diagnosis of myocardial involvement is challenging. Advanced imaging techniques play important roles in the diagnosis and management of patients with cardiac sarcoidosis. PMID:25784137

Multimodal neuroimaging in presurgical evaluation of drug-resistant epilepsy☆

PubMed Central

Zhang, Jing; Liu, Weifang; Chen, Hui; Xia, Hong; Zhou, Zhen; Mei, Shanshan; Liu, Qingzhu; Li, Yunlin

2013-01-01

Intracranial EEG (icEEG) monitoring is critical in epilepsy surgical planning, but it has limitations. The advances of neuroimaging have made it possible to reveal epileptic abnormalities that could not be identified previously and improve the localization of the seizure focus and the vital cortex. A frequently asked question in the field is whether non-invasive neuroimaging could replace invasive icEEG or reduce the need for icEEG in presurgical evaluation. This review considers promising neuroimaging techniques in epilepsy presurgical assessment in order to address this question. In addition, due to large variations in the accuracies of neuroimaging across epilepsy centers, multicenter neuroimaging studies are reviewed, and there is much need for randomized controlled trials (RCTs) to better reveal the utility of presurgical neuroimaging. The results of multiple studies indicate that non-invasive neuroimaging could not replace invasive icEEG in surgical planning especially in non-lesional or extratemporal lobe epilepsies, but it could reduce the need for icEEG in certain cases. With technical advances, multimodal neuroimaging may play a greater role in presurgical evaluation to reduce the costs and risks of epilepsy surgery, and provide surgical options for more patients with drug-resistant epilepsy. PMID:24282678

[Hypothyroidism incidence after multimodal treatment for laryngeal cancer].

PubMed

Ortega-Gutiérrez, César; Luna-Ortiz, Kuauhyama; Villavicencio-Valencia, Verónica; Herrera Gómez, Angel; Téllez-Palacios, Daniela; Contreras-Buendía, Marlen

2012-01-01

Hypothyroidism following total laryngectomy or radiotherapy treatment for laryngeal cancer is not a rare event, especially in advanced stages. There are no reports on the incidence of hypothyroidism in patients who received chemotherapy and radiotherapy. The objective of this study is to determine the incidence of thyroid dysfunction in a group of patients with laryngeal cancer who underwent surgery as sole treatment, total laryngectomy or radiotherapy alone, and patients with combined treatment: surgery plus radiotherapy, concomitant chemoradiation therapy and chemoradiation therapy plus salvage surgery. A prospective study of patients diagnosed with laryngeal cancer whose serum TSH and T4 levels were evaluated in a serial fashion. 70 patients with laryngeal cancer were studied; the average age at diagnosis was 70.2 years. Male patients were more affected, with a men-women ratio of 3.6:1. Glottic localization was the most frequent (44%). 64% of tumors were locally advanced carcinomas and 51% received multimodal treatment. 45 patients (63%) were diagnosed with hypothyroidism; 49% of the patients with subclinical hypothyroidism, and 51% with clinical hypothyroidism. Hypothyroidism is a complication following treatment for laryngeal cancer. It is recommended to evaluate the thyroid function periodically for timely detection.

Patients at Risk for Peritoneal Surface Malignancy of Colorectal Cancer Origin: The Role of Second Look Laparotomy

PubMed Central

Brücher, Björn LDM; Stojadinovic, Alexander; Bilchik, Anton J.; Protic, Mladjan; Daumer, Martin; Nissan, Aviram; Avital, Itzhak

2013-01-01

Peritoneal surface malignancy (PSM) is a frequent occurrence in the natural history of colorectal cancer (CRC). Although significant advances have been made in screening of CRC, similar progress has yet to be made in the early detection of PSM of colorectal cancer origin. The fact that advanced CRC can be confined to the peritoneal surface without distant dissemination forms the basis for aggressive multi-modality therapy consisting of cytoreductive surgery (CRS) plus hyperthermic intra-peritoneal chemotherapy (HIPEC), and neoadjuvant and/or adjuvant systemic therapy. Reported overall survival with complete CRS+HIPEC exceeds that of systemic therapy alone for the treatment of PSM from CRC, underscoring the advantage of this multi-modality therapeutic approach. Patients with limited peritoneal disease from CRC can undergo complete cytoreduction, which is associated with the best reported outcomes. As early or limited peritoneal carcinomatosis is undetectable by conventional imaging modalities, second look laparotomy is an important means to identify disease in high-risk patients at a stage most amenable to complete cytoreduction. This review focuses on the identification of patients at risk for PSM from CRC and discusses the role of second look laparotomy. PMID:23459716

Non-operative management of rectal cancer: understanding tumor biology.

PubMed

Wei, Iris H; Garcia-Aguilar, Julio

2018-05-24

The management of locally advanced rectal cancer involves a combination of chemotherapy, chemoradiation, and surgical resection to provide excellent local tumor control and overall survival. However, aspects of this multimodality approach are associated with significant morbidity and longterm sequelae. In addition, there is growing evidence that patients with a clinical complete response to chemotherapy and chemoradiation treatments may be safely offered initial non-operative management in a rigorous surveillance program. Developing effective methods, such as molecular biomarkers, to predict a patient's response to therapies are therefore needed to help guide personalized treatment strategies. The treatment of locally advanced rectal cancer focuses on a multimodality approach of systemic chemotherapy, radiation, and total mesorectal excision to maximize oncologic outcomes. While combined modality treatment for LARC results in excellent local tumor control and patient survival, the treatments are associated with significant morbidity and long-term functional complications that can impair quality of life. In addition, the tumor response to neoadjuvant therapy is quite variable.2 Weighed against the morbidity and significant sequelae of rectal resection, recognizing how to best optimize nonoperative strategies without compromising oncologic outcomes is critical to our understanding and treatment of this disease.

The connectome viewer toolkit: an open source framework to manage, analyze, and visualize connectomes.

PubMed

Gerhard, Stephan; Daducci, Alessandro; Lemkaddem, Alia; Meuli, Reto; Thiran, Jean-Philippe; Hagmann, Patric

2011-01-01

Advanced neuroinformatics tools are required for methods of connectome mapping, analysis, and visualization. The inherent multi-modality of connectome datasets poses new challenges for data organization, integration, and sharing. We have designed and implemented the Connectome Viewer Toolkit - a set of free and extensible open source neuroimaging tools written in Python. The key components of the toolkit are as follows: (1) The Connectome File Format is an XML-based container format to standardize multi-modal data integration and structured metadata annotation. (2) The Connectome File Format Library enables management and sharing of connectome files. (3) The Connectome Viewer is an integrated research and development environment for visualization and analysis of multi-modal connectome data. The Connectome Viewer's plugin architecture supports extensions with network analysis packages and an interactive scripting shell, to enable easy development and community contributions. Integration with tools from the scientific Python community allows the leveraging of numerous existing libraries for powerful connectome data mining, exploration, and comparison. We demonstrate the applicability of the Connectome Viewer Toolkit using Diffusion MRI datasets processed by the Connectome Mapper. The Connectome Viewer Toolkit is available from http://www.cmtk.org/

The Connectome Viewer Toolkit: An Open Source Framework to Manage, Analyze, and Visualize Connectomes

PubMed Central

Gerhard, Stephan; Daducci, Alessandro; Lemkaddem, Alia; Meuli, Reto; Thiran, Jean-Philippe; Hagmann, Patric

2011-01-01

Advanced neuroinformatics tools are required for methods of connectome mapping, analysis, and visualization. The inherent multi-modality of connectome datasets poses new challenges for data organization, integration, and sharing. We have designed and implemented the Connectome Viewer Toolkit – a set of free and extensible open source neuroimaging tools written in Python. The key components of the toolkit are as follows: (1) The Connectome File Format is an XML-based container format to standardize multi-modal data integration and structured metadata annotation. (2) The Connectome File Format Library enables management and sharing of connectome files. (3) The Connectome Viewer is an integrated research and development environment for visualization and analysis of multi-modal connectome data. The Connectome Viewer's plugin architecture supports extensions with network analysis packages and an interactive scripting shell, to enable easy development and community contributions. Integration with tools from the scientific Python community allows the leveraging of numerous existing libraries for powerful connectome data mining, exploration, and comparison. We demonstrate the applicability of the Connectome Viewer Toolkit using Diffusion MRI datasets processed by the Connectome Mapper. The Connectome Viewer Toolkit is available from http://www.cmtk.org/ PMID:21713110

Increasing trend of wearables and multimodal interface for human activity monitoring: A review.

PubMed

Kumari, Preeti; Mathew, Lini; Syal, Poonam

2017-04-15

Activity recognition technology is one of the most important technologies for life-logging and for the care of elderly persons. Elderly people prefer to live in their own houses, within their own locality. If, they are capable to do so, several benefits can follow in terms of society and economy. However, living alone may have high risks. Wearable sensors have been developed to overcome these risks and these sensors are supposed to be ready for medical uses. It can help in monitoring the wellness of elderly persons living alone by unobtrusively monitoring their daily activities. The study aims to review the increasing trends of wearable devices and need of multimodal recognition for continuous or discontinuous monitoring of human activity, biological signals such as Electroencephalogram (EEG), Electrooculogram (EOG), Electromyogram (EMG), Electrocardiogram (ECG) and parameters along with other symptoms. This can provide necessary assistance in times of ominous need, which is crucial for the advancement of disease-diagnosis and treatment. Shared control architecture with multimodal interface can be used for application in more complex environment where more number of commands is to be used to control with better results in terms of controlling. Copyright © 2016 Elsevier B.V. All rights reserved.

Laser-driven x-ray and neutron source development for industrial applications of plasma accelerators

NASA Astrophysics Data System (ADS)

Brenner, C. M.; Mirfayzi, S. R.; Rusby, D. R.; Armstrong, C.; Alejo, A.; Wilson, L. A.; Clarke, R.; Ahmed, H.; Butler, N. M. H.; Haddock, D.; Higginson, A.; McClymont, A.; Murphy, C.; Notley, M.; Oliver, P.; Allott, R.; Hernandez-Gomez, C.; Kar, S.; McKenna, P.; Neely, D.

2016-01-01

Pulsed beams of energetic x-rays and neutrons from intense laser interactions with solid foils are promising for applications where bright, small emission area sources, capable of multi-modal delivery are ideal. Possible end users of laser-driven multi-modal sources are those requiring advanced non-destructive inspection techniques in industry sectors of high value commerce such as aerospace, nuclear and advanced manufacturing. We report on experimental work that demonstrates multi-modal operation of high power laser-solid interactions for neutron and x-ray beam generation. Measurements and Monte Carlo radiation transport simulations show that neutron yield is increased by a factor ~2 when a 1 mm copper foil is placed behind a 2 mm lithium foil, compared to using a 2 cm block of lithium only. We explore x-ray generation with a 10 picosecond drive pulse in order to tailor the spectral content for radiography with medium density alloy metals. The impact of using  >1 ps pulse duration on laser-accelerated electron beam generation and transport is discussed alongside the optimisation of subsequent bremsstrahlung emission in thin, high atomic number target foils. X-ray spectra are deconvolved from spectrometer measurements and simulation data generated using the GEANT4 Monte Carlo code. We also demonstrate the unique capability of laser-driven x-rays in being able to deliver single pulse high spatial resolution projection imaging of thick metallic objects. Active detector radiographic imaging of industrially relevant sample objects with a 10 ps drive pulse is presented for the first time, demonstrating that features of 200 μm size are resolved when projected at high magnification.

Preterm EEG: a multimodal neurophysiological protocol.

PubMed

Stjerna, Susanna; Voipio, Juha; Metsäranta, Marjo; Kaila, Kai; Vanhatalo, Sampsa

2012-02-18

Since its introduction in early 1950s, electroencephalography (EEG) has been widely used in the neonatal intensive care units (NICU) for assessment and monitoring of brain function in preterm and term babies. Most common indications are the diagnosis of epileptic seizures, assessment of brain maturity, and recovery from hypoxic-ischemic events. EEG recording techniques and the understanding of neonatal EEG signals have dramatically improved, but these advances have been slow to penetrate through the clinical traditions. The aim of this presentation is to bring theory and practice of advanced EEG recording available for neonatal units. In the theoretical part, we will present animations to illustrate how a preterm brain gives rise to spontaneous and evoked EEG activities, both of which are unique to this developmental phase, as well as crucial for a proper brain maturation. Recent animal work has shown that the structural brain development is clearly reflected in early EEG activity. Most important structures in this regard are the growing long range connections and the transient cortical structure, subplate. Sensory stimuli in a preterm baby will generate responses that are seen at a single trial level, and they have underpinnings in the subplate-cortex interaction. This brings neonatal EEG readily into a multimodal study, where EEG is not only recording cortical function, but it also tests subplate function via different sensory modalities. Finally, introduction of clinically suitable dense array EEG caps, as well as amplifiers capable of recording low frequencies, have disclosed multitude of brain activities that have as yet been overlooked. In the practical part of this video, we show how a multimodal, dense array EEG study is performed in neonatal intensive care unit from a preterm baby in the incubator. The video demonstrates preparation of the baby and incubator, application of the EEG cap, and performance of the sensory stimulations.

News and Views: Research council resource allocations: managing demand; e-MERLIN radio telescope network is up and running

NASA Astrophysics Data System (ADS)

2011-02-01

The research councils discovered in December the allocation of money from the UK government's Comprehensive Spending Review, and have set out their delivery plans outlining how they will spend it. Details and decisions will follow consultation in the coming months. The first image from eMerlin, the UK's national radio astronomy facility, shows the power of the enhanced network of radio telescopes spread over 220 km and now linked by fibre optics. These links and advanced receivers will allow astronomers to see in a single day what would have previously taken them more than a year of observations.

Advances in Spatial Data Infrastructure, Acquisition, Analysis, Archiving and Dissemination

NASA Technical Reports Server (NTRS)

Ramapriyan, Hampapuran K.; Rochon, Gilbert L.; Duerr, Ruth; Rank, Robert; Nativi, Stefano; Stocker, Erich Franz

2010-01-01

The authors review recent contributions to the state-of-thescience and benign proliferation of satellite remote sensing, spatial data infrastructure, near-real-time data acquisition, analysis on high performance computing platforms, sapient archiving, multi-modal dissemination and utilization for a wide array of scientific applications. The authors also address advances in Geoinformatics and its growing ubiquity, as evidenced by its inclusion as a focus area within the American Geophysical Union (AGU), European Geosciences Union (EGU), as well as by the evolution of the IEEE Geoscience and Remote Sensing Society's (GRSS) Data Archiving and Distribution Technical Committee (DAD TC).

The sixth generation robot in space

NASA Technical Reports Server (NTRS)

Butcher, A.; Das, A.; Reddy, Y. V.; Singh, H.

1990-01-01

The knowledge based simulator developed in the artificial intelligence laboratory has become a working test bed for experimenting with intelligent reasoning architectures. With this simulator, recently, small experiments have been done with an aim to simulate robot behavior to avoid colliding paths. An automatic extension of such experiments to intelligently planning robots in space demands advanced reasoning architectures. One such architecture for general purpose problem solving is explored. The robot, seen as a knowledge base machine, goes via predesigned abstraction mechanism for problem understanding and response generation. The three phases in one such abstraction scheme are: abstraction for representation, abstraction for evaluation, and abstraction for resolution. Such abstractions require multimodality. This multimodality requires the use of intensional variables to deal with beliefs in the system. Abstraction mechanisms help in synthesizing possible propagating lattices for such beliefs. The machine controller enters into a sixth generation paradigm.

Latest results of the Tunka Radio Extension

NASA Astrophysics Data System (ADS)

Kostunin, D.; Bezyazeekov, P. A.; Budnev, N. M.; Fedorov, O.; Gress, O. A.; Haungs, A.; Hiller, R.; Huege, T.; Kazarina, Y.; Kleifges, M.; Korosteleva, E. E.; Krömer, O.; Kungel, V.; Kuzmichev, L. A.; Lubsandorzhiev, N.; Marshalkina, T.; Mirgazov, R. R.; Monkhoev, R.; Osipova, E. A.; Pakhorukov, A.; Pankov, L.; Prosin, V. V.; Rubtsov, G. I.; Schröder, F. G.; Wischnewski, R.; Zagorodnikov, A.

2017-06-01

The Tunka Radio Extension (Tunka-Rex) is an antenna array consisting of 63 antennas at the location of the TAIGA facility (Tunka Advanced Instrument for cosmic ray physics and Gamma Astronomy) in Eastern Siberia, nearby Lake Baikal. Tunka-Rex is triggered by the air-Cherenkov array Tunka-133 during clear and moonless winter nights and by the scintillator array Tunka-Grande during the remaining time. Tunka-Rex measures the radio emission from the same air-showers as Tunka-133 and Tunka-Grande, but with a higher threshold of about 100 PeV. During the first stages of its operation, Tunka-Rex has proven, that sparse radio arrays can measure air-showers with an energy resolution of better than 15% and the depth of the shower maximum with a resolution of better than 40 g/cm2. To improve and interpret our measurements as well as to study systematic uncertainties due to interaction models, we perform radio simulations with CORSIKA and CoREAS. In this overview we present the setup of Tunka-Rex, discuss the achieved results and the prospects of mass-composition studies with radio arrays.

Initial Results of HamSCI Ham Radio 21 August 2017 Eclipse Ionospheric Experiments

NASA Astrophysics Data System (ADS)

Frissell, N. A.; Gerrard, A. J.; Vega, J. S.; Katz, J. D.; West, M. L.; Gunning, S. W.; Moses, M. L.; Miller, E. S.; Erickson, P. J.; Huba, J.; Silver, H. W.; Ceglia, F.; Smith, P.; Williams, R.; Shovkoplyas, A.; Earle, G. D.; Gerzoff, R.; Gladstone, P.; Reyer, S. E.; Ackermann, J. R.; Bern, D.; Rose, S. W.

2017-12-01

On 21 August 2017, a total solar eclipse will cause the shadow of the moon to traverse the United States from Oregon to South Carolina in just over 90 minutes. The sudden absence of sunlight due to the eclipse, especially solar UV and x-rays, provides an impulse function to the upper atmosphere that modifies the neutral dynamics, plasma concentrations, and related properties. Despite more than 60 years of research, questions remain regarding eclipse-induced ionospheric impacts. Ham radio operators' advanced technical skills and inherent interest in ionospheric science make the amateur radio community ideal for contributing to and and participating in large-scale ionospheric sounding experiments. We present initial results from three amateur radio experiments designed to study the 2017 total solar eclipse: the Solar Eclipse QSO Party (SEQP), the HF Wideband Recording Experiment, and the Eclipse Frequency Measurement Test (FMT). These experiments are coordinated by HamSCI, the Ham Radio Science Citizen Investigation, a citizen science organization that connects the amateur radio community to the professional space science research community for mutual benefit.

Depletion of hepatoma-derived growth factor-related protein-3 induces apoptotic sensitization of radioresistant A549 cells via reactive oxygen species-dependent p53 activation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yun, Hong Shik; Hong, Eun-Hee; Department of Chemistry, College of Natural Sciences, Hanyang University, Seoul 133-791

2013-09-27

Highlights: •HRP-3 is a radiation- and anticancer drug-responsive protein in A549 cells. •Depletion of HRP-3 induces apoptosis of radio- and chemoresistant A549 cells. •Depletion of HRP-3 promotes ROS generation via inhibition of the Nrf2/HO-1 pathway. •Depletion of HRP-3 enhances ROS-dependent p53 activation and PUMA expression. -- Abstract: Biomarkers based on functional signaling have the potential to provide greater insight into the pathogenesis of cancer and may offer additional targets for anticancer therapeutics. Here, we identified hepatoma-derived growth factor-related protein-3 (HRP-3) as a radioresistance-related gene and characterized the molecular mechanism by which its encoded protein regulates the radio- and chemoresistant phenotypemore » of lung cancer-derived A549 cells. Knockdown of HRP-3 promoted apoptosis of A549 cells and potentiated the apoptosis-inducing action of radio- and chemotherapy. This increase in apoptosis was associated with a substantial generation of reactive oxygen species (ROS) that was attributable to inhibition of the Nrf2/HO-1 antioxidant pathway and resulted in enhanced ROS-dependent p53 activation and p53-dependent expression of PUMA (p53 upregulated modulator of apoptosis). Therefore, the HRP-3/Nrf2/HO-1/ROS/p53/PUMA cascade is an essential feature of the A549 cell phenotype and a potential radiotherapy target, extending the range of targets in multimodal therapies against lung cancer.« less

BioRadioTransmitter: a self-powered wireless glucose-sensing system.

PubMed

Hanashi, Takuya; Yamazaki, Tomohiko; Tsugawa, Wakako; Ikebukuro, Kazunori; Sode, Koji

2011-09-01

Although an enzyme fuel cell can be utilized as a glucose sensor, the output power generated is too low to power a device such as a currently available transmitter and operating system, and an external power source is required for operating an enzyme-fuel-cell-based biosensing system. We proposed a novel biosensor that we named BioCapacitor, in which a capacitor serves as a transducer. In this study, we constructed a new BioCapacitor-based system with an added radio-transmitter circuit and a miniaturized enzyme fuel cell. A miniaturized direct-electron-transfer-type compartmentless enzyme fuel cell was constructed with flavin adenine dinucleotide-dependent glucose dehydrogenase complex-based anode and a bilirubin-oxidase-based cathode. For construction of a BioRadioTransmitter wireless sensing system, a capacitor, an ultra-low-voltage charge-pump-integrated circuit, and Hartley oscillator circuit were connected to the miniaturized enzyme fuel cell. A radio-receiver circuit, comprising two field-effect transistors and a coil as an antenna, was used to amplify the signal generated from the biofuel cells. Radio wave signals generated by the BioRadioTransmitter were received, amplified, and converted from alternate to direct current by the radio receiver. When the capacitor discharges in the presence of glucose, the BioRadioTransmitter generates a radio wave, which is monitored by a radio receiver connected wirelessly to the sensing device. Magnitude of the radio wave transmission frequency change observed at the radio receiver was correlated to glucose concentration in the fuel cells. We constructed a stand-alone, self-powered, wireless glucose-sensing system called a BioRadioTransmitter by using a radio transmitter in which the radio wave transmission frequency changes with the glucose concentration in the fuel cell. The BioRadioTransmitter is a significant advance toward construction of an implantable continuous glucose monitor. © 2011 Diabetes Technology Society.

(abstract) Deep Space Network Radiometric Remote Sensing Program

NASA Technical Reports Server (NTRS)

Walter, Steven J.

1994-01-01

Planetary spacecraft are viewed through a troposphere that absorbs and delays radio signals propagating through it. Tropospheric water, in the form of vapor, cloud liquid,and precipitation , emits radio noise which limits satellite telemetry communication link performance. Even at X-band, rain storms have severely affected several satellite experiments including a planetary encounter. The problem will worsen with DSN implementation of Ka-band becausecommunication link budgets will be dominated by tropospheric conditions. Troposphere-induced propagation delays currently limit VLBI accuracy and are significant sources of error for Doppler tracking. Additionally, the success of radio science programs such as satellite gravity wave experiments and atmospheric occultation experiments depends on minimizing the effect of watervapor-induced prop agation delays. In order to overcome limitations imposed by the troposphere, the Deep Space Network has supported a program of radiometric remote sensing. Currently, water vapor radiometers (WVRs) and microwave temperature profilers (MTPs) support many aspects of the Deep Space Network operations and research and development programs. Their capability to sense atmospheric water, microwave sky brightness, and atmospheric temperature is critical to development of Ka-band telemetry systems, communication link models, VLBI, satellite gravity waveexperiments, and r adio science missions. During 1993, WVRs provided data for propagation mode development, supp orted planetary missions, and demonstrated advanced tracking capability. Collection of atmospheric statistics is necessary to model and predict performance of Ka-band telemetry links, antenna arrays, and radio science experiments. Since the spectrum of weather variations has power at very long time scales, atmospheric measurements have been requested for periods ranging from one year to a decade at each DSN site. The resulting database would provide reliable statistics on daily, monthly, and seasonal variations. Only long-term monitoring will prevent biases from being introduced by an exceptionally wet or dry year. Support for planetary missions included tropospheric calibration for the recent Mars Observer gravity wave experiments and Ka-band link experiment (KaBLE). Additionally, several proposed radio science experiments such as profiling planetary atmospheres using satellite occultations and Ka-band gravitational wave searches require advanced radiometer technology development. Finally, there has been a consistent advanced technology program to advance satellite navigational and tracking capabilities. This year that included an experiment with radiometer based tropospheric calibration for a series of VLBI catalog measurements.

Latest advances in molecular imaging instrumentation.

PubMed

Pichler, Bernd J; Wehrl, Hans F; Judenhofer, Martin S

2008-06-01

This review concentrates on the latest advances in molecular imaging technology, including PET, MRI, and optical imaging. In PET, significant improvements in tumor detection and image resolution have been achieved by introducing new scintillation materials, iterative image reconstruction, and correction methods. These advances enabled the first clinical scanners capable of time-of-flight detection and incorporating point-spread-function reconstruction to compensate for depth-of-interaction effects. In the field of MRI, the most important developments in recent years have mainly been MRI systems with higher field strengths and improved radiofrequency coil technology. Hyperpolarized imaging, functional MRI, and MR spectroscopy provide molecular information in vivo. A special focus of this review article is multimodality imaging and, in particular, the emerging field of combined PET/MRI.

A radio counterpart to a neutron star merger.

PubMed

Hallinan, G; Corsi, A; Mooley, K P; Hotokezaka, K; Nakar, E; Kasliwal, M M; Kaplan, D L; Frail, D A; Myers, S T; Murphy, T; De, K; Dobie, D; Allison, J R; Bannister, K W; Bhalerao, V; Chandra, P; Clarke, T E; Giacintucci, S; Ho, A Y Q; Horesh, A; Kassim, N E; Kulkarni, S R; Lenc, E; Lockman, F J; Lynch, C; Nichols, D; Nissanke, S; Palliyaguru, N; Peters, W M; Piran, T; Rana, J; Sadler, E M; Singer, L P

2017-12-22

Gravitational waves have been detected from a binary neutron star merger event, GW170817. The detection of electromagnetic radiation from the same source has shown that the merger occurred in the outskirts of the galaxy NGC 4993, at a distance of 40 megaparsecs from Earth. We report the detection of a counterpart radio source that appears 16 days after the event, allowing us to diagnose the energetics and environment of the merger. The observed radio emission can be explained by either a collimated ultrarelativistic jet, viewed off-axis, or a cocoon of mildly relativistic ejecta. Within 100 days of the merger, the radio light curves will enable observers to distinguish between these models, and the angular velocity and geometry of the debris will be directly measurable by very long baseline interferometry. Copyright © 2017, American Association for the Advancement of Science.

Space Communication and Navigation SDR Testbed, Overview and Opportunity for Experiments

NASA Technical Reports Server (NTRS)

Reinhart, Richard C.

2013-01-01

NASA has developed an experimental flight payload (referred to as the Space Communication and Navigation (SCAN) Test Bed) to investigate software defined radio (SDR) communications, networking, and navigation technologies, operationally in the space environment. The payload consists of three software defined radios each compliant to NASAs Space Telecommunications Radio System Architecture, a common software interface description standard for software defined radios. The software defined radios are new technology developments underway by NASA and industry partners launched in 2012. The payload is externally mounted to the International Space Station truss to conduct experiments representative of future mission capability. Experiment operations include in-flight reconfiguration of the SDR waveform functions and payload networking software. The flight system will communicate with NASAs orbiting satellite relay network, the Tracking and Data Relay Satellite System at both S-band and Ka-band and to any Earth-based compatible S-band ground station. The system is available for experiments by industry, academia, and other government agencies to participate in the SDR technology assessments and standards advancements.

Mechatronics in monitoring, simulation, and diagnostics of industrial and biological processes

NASA Astrophysics Data System (ADS)

Golnik, Natalia; Dobosz, Marek; Jakubowska, Małgorzata; Kościelny, Jan M.; Kujawińska, Małgorzata; Pałko, Tadeusz; Putz, Barbara; Sitnik, Robert; Wnuk, Paweł; Woźniak, Adam

2013-10-01

The paper describes a number of research projects of the Faculty of Mechatronics of Warsaw University of Technology in order to illustrate the use of common mechatronics and optomechatronics approach in solving multidisciplinary technical problems. Projects on sensors development, measurement and industrial control systems, multimodal data capture and advance systems for monitoring and diagnostics of industrial processes are presented and discussed.

MOVEMENT AND MANEUVER IN DEEP SPACE: A Framework to Leverage Advanced Propulsion

DTIC Science & Technology

2018-04-01

Enterprise, and for this reason alone demands attention in the form of disciplined investment. Furthermore, because the core functional capability...technologies while collaborating with agencies and organizations external to the USAF. Section 2.2 discusses a theoretical organization formed and...engines, signature reduction, and thrust vectoring. AFRL is pursuing the attributes listed above in different forms , particularly via multi-mode

Movement and Maneuver in Deep Space: A Framework to Leverage Advanced Propulsion

DTIC Science & Technology

2017-04-01

array of benefits for the current National Security Enterprise, and for this reason alone demands attention in the form of disciplined investment...discusses a theoretical organization formed and chartered to develop, test, and acquire deep space propulsion technology and includes what the...different forms , particularly via multi-mode propulsion where both chemical thrusters and electric propulsion devices operate on a common

The utility of high-resolution intraoperative MRI in endoscopic transsphenoidal surgery for pituitary macroadenomas: early experience in the Advanced Multimodality Image Guided Operating suite.

PubMed

Zaidi, Hasan A; De Los Reyes, Kenneth; Barkhoudarian, Garni; Litvack, Zachary N; Bi, Wenya Linda; Rincon-Torroella, Jordina; Mukundan, Srinivasan; Dunn, Ian F; Laws, Edward R

2016-03-01

Endoscopic skull base surgery has become increasingly popular among the skull base surgery community, with improved illumination and angled visualization potentially improving tumor resection rates. Intraoperative MRI (iMRI) is used to detect residual disease during the course of the resection. This study is an investigation of the utility of 3-T iMRI in combination with transnasal endoscopy with regard to gross-total resection (GTR) of pituitary macroadenomas. The authors retrospectively reviewed all endoscopic transsphenoidal operations performed in the Advanced Multimodality Image Guided Operating (AMIGO) suite from November 2011 to December 2014. Inclusion criteria were patients harboring presumed pituitary macroadenomas with optic nerve or chiasmal compression and visual loss, operated on by a single surgeon. Of the 27 patients who underwent transsphenoidal resection in the AMIGO suite, 20 patients met the inclusion criteria. The endoscope alone, without the use of iMRI, would have correctly predicted extent of resection in 13 (65%) of 20 cases. Gross-total resection was achieved in 12 patients (60%) prior to MRI. Intraoperative MRI helped convert 1 STR and 4 NTRs to GTRs, increasing the number of GTRs from 12 (60%) to 16 (80%). Despite advances in visualization provided by the endoscope, the incidence of residual disease can potentially place the patient at risk for additional surgery. The authors found that iMRI can be useful in detecting unexpected residual tumor. The cost-effectiveness of this tool is yet to be determined.

GLOBECOM '87 - Global Telecommunications Conference, Tokyo, Japan, Nov. 15-18, 1987, Conference Record. Volumes 1, 2, & 3

NASA Astrophysics Data System (ADS)

The present conference on global telecommunications discusses topics in the fields of Integrated Services Digital Network (ISDN) technology field trial planning and results to date, motion video coding, ISDN networking, future network communications security, flexible and intelligent voice/data networks, Asian and Pacific lightwave and radio systems, subscriber radio systems, the performance of distributed systems, signal processing theory, satellite communications modulation and coding, and terminals for the handicapped. Also discussed are knowledge-based technologies for communications systems, future satellite transmissions, high quality image services, novel digital signal processors, broadband network access interface, traffic engineering for ISDN design and planning, telecommunications software, coherent optical communications, multimedia terminal systems, advanced speed coding, portable and mobile radio communications, multi-Gbit/second lightwave transmission systems, enhanced capability digital terminals, communications network reliability, advanced antimultipath fading techniques, undersea lightwave transmission, image coding, modulation and synchronization, adaptive signal processing, integrated optical devices, VLSI technologies for ISDN, field performance of packet switching, CSMA protocols, optical transport system architectures for broadband ISDN, mobile satellite communications, indoor wireless communication, echo cancellation in communications, and distributed network algorithms.

Complementary optical and nuclear imaging of caspase-3 activity using combined activatable and radio-labeled multimodality molecular probe.

PubMed

Lee, Hyeran; Akers, Walter J; Cheney, Philip P; Edwards, W Barry; Liang, Kexian; Culver, Joseph P; Achilefu, Samuel

2009-01-01

Based on the capability of modulating fluorescence intensity by specific molecular events, we report a new multimodal optical-nuclear molecular probe with complementary reporting strategies. The molecular probe (LS498) consists of tetraazacyclododecanetetraacetic acid (DOTA) for chelating a radionuclide, a near-infrared fluorescent dye, and an efficient quencher dye. The two dyes are separated by a cleavable peptide substrate for caspase-3, a diagnostic enzyme that is upregulated in dying cells. LS498 is radiolabeled with (64)Cu, a radionuclide used in positron emission tomography. In the native form, LS498 fluorescence is quenched until caspase-3 cleavage of the peptide substrate. Enzyme kinetics assay shows that LS498 is readily cleaved by caspase-3, with excellent enzyme kinetic parameters k(cat) and K(M) of 0.55+/-0.01 s(-1) and 1.12+/-0.06 microM, respectively. In mice, the initial fluorescence of LS498 is ten-fold less than control. Using radiolabeled (64)Cu-LS498 in a controlled and localized in-vivo model of caspase-3 activation, a time-dependent five-fold NIR fluorescence enhancement is observed, but radioactivity remains identical in caspase-3 positive and negative controls. These results demonstrate the feasibility of using radionuclide imaging for localizing and quantifying the distribution of molecular probes and optical imaging for reporting the functional status of diagnostic enzymes.

Complementary optical and nuclear imaging of caspase-3 activity using combined activatable and radio-labeled multimodality molecular probe

NASA Astrophysics Data System (ADS)

Lee, Hyeran; Akers, Walter J.; Cheney, Philip P.; Edwards, W. Barry; Liang, Kexian; Culver, Joseph P.; Achilefu, Samuel

2009-07-01

Based on the capability of modulating fluorescence intensity by specific molecular events, we report a new multimodal optical-nuclear molecular probe with complementary reporting strategies. The molecular probe (LS498) consists of tetraazacyclododecanetetraacetic acid (DOTA) for chelating a radionuclide, a near-infrared fluorescent dye, and an efficient quencher dye. The two dyes are separated by a cleavable peptide substrate for caspase-3, a diagnostic enzyme that is upregulated in dying cells. LS498 is radiolabeled with 64Cu, a radionuclide used in positron emission tomography. In the native form, LS498 fluorescence is quenched until caspase-3 cleavage of the peptide substrate. Enzyme kinetics assay shows that LS498 is readily cleaved by caspase-3, with excellent enzyme kinetic parameters kcat and KM of 0.55+/-0.01 s-1 and 1.12+/-0.06 μM, respectively. In mice, the initial fluorescence of LS498 is ten-fold less than control. Using radiolabeled 64Cu-LS498 in a controlled and localized in-vivo model of caspase-3 activation, a time-dependent five-fold NIR fluorescence enhancement is observed, but radioactivity remains identical in caspase-3 positive and negative controls. These results demonstrate the feasibility of using radionuclide imaging for localizing and quantifying the distribution of molecular probes and optical imaging for reporting the functional status of diagnostic enzymes.

Calibration of a speckle-based compressive sensing receiver

NASA Astrophysics Data System (ADS)

Sefler, George A.; Shaw, T. Justin; Stapleton, Andrew D.; Valley, George C.

2017-02-01

Optical speckle in a multimode waveguide has been proposed to perform the function of a compressive sensing (CS) measurement matrix (MM) in a receiver for GHz-band radio frequency (RF) signals. Unlike other devices used for the CS MM, e.g. the digital micromirror device (DMD) used in the single pixel camera, the elements of the speckle MM are not known before use and must be measured and calibrated. In our system, the RF signal is modulated on a repetitively pulsed chirped wavelength laser source, generated from mode-locked laser pulses that have been dispersed in time or from an electrically addressed distributed Bragg reflector laser. Next, the optical beam with RF propagates through a multimode fiber or waveguide, which applies different weights in wavelength (or equivalently time) and space and performs the function of the CS MM. The output of the guide is directed to or imaged on a bank of photodiodes with integration time set to the pulse length of the chirp waveform. The output of each photodiode is digitized by an analog-to-digital converter (ADC), and the data from these ADCs are used to form the CS measurement vector. Accurate recovery of the RF signal from CS measurements depends critically on knowledge of the weights in the MM. Here we present results using a stable wavelength laser source to probe the guide.

Refractive-index-sensing fiber comb using intracavity multi-mode interference fiber sensor

NASA Astrophysics Data System (ADS)

Oe, Ryo; Minamikawa, Takeo; Taue, Shuji; Fukano, Hideki; Nakajima, Yoshiaki; Minoshima, Kaoru; Yasui, Takeshi

2018-02-01

Refractive index measurement is important for evaluation of liquid materials, optical components, and bio sensing. One promising approach for such measurement is use of optical fiber sensors such as surface plasmonic resonance or multi-mode interference (MMI), which measure the change of optical spectrum resulting from the refractive index change. However, the precision of refractive index measurement is limited by the performance of optical spectrum analyzer. If such the refractive index measurement can be performed in radio frequency (RF) region in place of optical region, the measurement precision will be further improved by the frequency-standard-based RF measurement. To this end, we focus on the disturbance-to-RF conversion in a fiber optical frequency comb (OFC) cavity. Since frequency spacing frep of OFC depends on an optical cavity length nL, frep sensitively reflects the external disturbance interacted with nL. Although we previously demonstrated the precise strain measurement based on the frep measurement, the measurable physical quantity is limited to strain or temperature, which directly interacts with the fiber cavity itself. If a functional fiber sensor can be installed into the fiber OFC cavity, the measurable physical quantity will be largely expanded. In this paper, we introduce a MMI fiber sensor into a ring-type fiber OFC cavity for refractive index measurement. We confirmed the refractive-index-dependent frep shift.

CRS-HIPEC Prolongs Survival but is Not Curative for Patients with Peritoneal Carcinomatosis of Gastric Cancer.

PubMed

Boerner, T; Graichen, A; Jeiter, T; Zemann, F; Renner, P; März, L; Soeder, Y; Schlitt, H J; Piso, P; Dahlke, M H

2016-11-01

Peritoneal carcinomatosis (PC) is a dismal feature of gastric cancer that most often is treated by systemic palliative chemotherapy. In this retrospective matched pairs-analysis, we sought to establish whether specific patient subgroups alternatively should be offered a multimodal therapy concept, including cytoreductive surgery (CRS) and intraoperative hyperthermic chemotherapy (HIPEC). Clinical outcomes of 38 consecutive patients treated with gastrectomy, CRS and HIPEC for advanced gastric cancer with PC were compared to patients treated by palliative management (with and without gastrectomy) and to patients with advanced gastric cancer with no evidence of PC. Kaplan-Meier survival curves and multivariate Cox regression models were applied. Median survival time after gastrectomy was similar between patients receiving CRS-HIPEC and matched control patients operated for advanced gastric cancer without PC [18.1 months, confidence interval (CI) 10.1-26.0 vs. 21.8 months, CI 8.0-35.5 months], resulting in comparable 5-year survival (11.9 vs. 12.1 %). The median survival time after first diagnosis of PC for gastric cancer was 17.2 months (CI 10.1-24.2 months) in the CRS-HIPEC group compared with 11.0 months (CI 7.4-14.6 months) for those treated by gastrectomy and chemotherapy alone, resulting in a twofold increase of 2-year survival (35.8 vs. 16.9 %). We provide retrospective evidence that multimodal treatment with gastrectomy, CRS, and HIPEC is associated with improved survival for patients with PC of advanced gastric cancer compared with gastrectomy and palliative chemotherapy alone. We also show that patients treated with CRS-HIPEC have comparable survival to matched control patients without PC. However, regardless of treatment scheme, all patients subsequently recur and die of disease.

Esophageal Cancer: New Insights into a Heterogenous Disease.

PubMed

Krug, Sebastian; Michl, Patrick

2017-01-01

Esophageal cancer represents a heterogeneous malignancy mostly diagnosed in advanced stages. Worldwide, squamous cell carcinomas (SCCs) continue to be the most prevalent subtype; however, in the Western countries, the incidence of adenocarcinomas is increasing and will exceed that of SCC in the near future. During the last decade, several landmark trials contributed to a better understanding of the disease and emphasized the importance of multimodal treatment protocols. With the introduction of perioperative or neoadjuvant approaches, the survival of both subtypes of esophageal cancer has significantly improved. Several trials confirmed a survival benefit for perioperative chemotherapy or neoadjuvant chemoradiation, respectively, for patients with resectable locally advanced adenocarcinomas. However, the question of whether perioperative chemotherapy or neoadjuvant chemoradiation is more effective for the long-term survival in this population has yet to be fully elucidated. In SCCs, neoadjuvant chemoradiation followed by surgery or definitive chemoradiation in case of functional inoperability represent the preferred treatment options. Compared to neoadjuvant protocols, adjuvant chemotherapy or chemoradiation have only minor effects and are associated with enhanced toxicities. Current preclinical and clinical trials investigate efficacy and tolerability of novel drugs aiming to modulate immune check-points and dual inhibition of HER2. In this "to-the-point" article, we review the current standard and summarize the most recent and encouraging therapeutic advances in esophageal cancer. Multimodal treatment approaches for esophageal cancer should be discussed in a multidisciplinary team based on histology, tumor localization, and patient performance status. Neoadjuvant chemoradiation is beneficial for patients with locally advanced SCC and adenocarcinomas of the esophagus and the gastroesophageal junction (GEJ), with perioperative chemotherapy representing a valid alternative for GEJ adenocarcinomas. Combination therapies are indicated for metastatic adenocarcinomas, while the benefit of palliative chemotherapy in SCC remains controversial. Trastuzumab is indicated in HER2+ metastatic adenocarcinomas. © 2017 S. Karger AG, Basel.

WE-H-206-00: Advances in Preclinical Imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

Lihong V. Wang: Photoacoustic tomography (PAT), combining non-ionizing optical and ultrasonic waves via the photoacoustic effect, provides in vivo multiscale functional, metabolic, and molecular imaging. Broad applications include imaging of the breast, brain, skin, esophagus, colon, vascular system, and lymphatic system in humans or animals. Light offers rich contrast but does not penetrate biological tissue in straight paths as x-rays do. Consequently, high-resolution pure optical imaging (e.g., confocal microscopy, two-photon microscopy, and optical coherence tomography) is limited to penetration within the optical diffusion limit (∼1 mm in the skin). Ultrasonic imaging, on the contrary, provides fine spatial resolution but suffersmore » from both poor contrast in early-stage tumors and strong speckle artifacts. In PAT, pulsed laser light penetrates tissue and generates a small but rapid temperature rise, which induces emission of ultrasonic waves due to thermoelastic expansion. The ultrasonic waves, orders of magnitude less scattering than optical waves, are then detected to form high-resolution images of optical absorption at depths up to 7 cm, conquering the optical diffusion limit. PAT is the only modality capable of imaging across the length scales of organelles, cells, tissues, and organs (up to whole-body small animals) with consistent contrast. This rapidly growing technology promises to enable multiscale biological research and accelerate translation from microscopic laboratory discoveries to macroscopic clinical practice. PAT may also hold the key to label-free early detection of cancer by in vivo quantification of hypermetabolism, the quintessential hallmark of malignancy. Learning Objectives: To understand the contrast mechanism of PAT To understand the multiscale applications of PAT Benjamin M. W. Tsui: Multi-modality molecular imaging instrumentation and techniques have been major developments in small animal imaging that has contributed significantly to biomedical research during the past decade. The initial development was an extension of clinical PET/CT and SPECT/CT from human to small animals and combine the unique functional information obtained from PET and SPECT with anatomical information provided by the CT in registered multi-modality images. The requirements to image a mouse whose size is an order of magnitude smaller than that of a human have spurred advances in new radiation detector technologies, novel imaging system designs and special image reconstruction and processing techniques. Examples are new detector materials and designs with high intrinsic resolution, multi-pinhole (MPH) collimator design for much improved resolution and detection efficiency compared to the conventional collimator designs in SPECT, 3D high-resolution and artifact-free MPH and sparse-view image reconstruction techniques, and iterative image reconstruction methods with system response modeling for resolution recovery and image noise reduction for much improved image quality. The spatial resolution of PET and SPECT has improved from ∼6–12 mm to ∼1 mm a few years ago to sub-millimeter today. A recent commercial small animal SPECT system has achieved a resolution of ∼0.25 mm which surpasses that of a state-of-art PET system whose resolution is limited by the positron range. More recently, multimodality SA PET/MRI and SPECT/MRI systems have been developed in research laboratories. Also, multi-modality SA imaging systems that include other imaging modalities such as optical and ultrasound are being actively pursued. In this presentation, we will provide a review of the development, recent advances and future outlook of multi-modality molecular imaging of small animals. Learning Objectives: To learn about the two major multi-modality molecular imaging techniques of small animals. To learn about the spatial resolution achievable by the molecular imaging systems for small animal today. To learn about the new multi-modality imaging instrumentation and techniques that are being developed. Sang Hyun Cho; X-ray fluorescence (XRF) imaging, such as x-ray fluorescence computed tomography (XFCT), offers unique capabilities for accurate identification and quantification of metals within the imaging objects. As a result, it has emerged as a promising quantitative imaging modality in recent years, especially in conjunction with metal-based imaging probes. This talk will familiarize the audience with the basic principles of XRF/XFCT imaging. It will also cover the latest development of benchtop XFCT technology. Additionally, the use of metallic nanoparticles such as gold nanoparticles, in conjunction with benchtop XFCT, will be discussed within the context of preclinical multimodal multiplexed molecular imaging. Learning Objectives: To learn the basic principles of XRF/XFCT imaging To learn the latest advances in benchtop XFCT development for preclinical imaging Funding support received from NIH and DOD; Funding support received from GE Healthcare; Funding support received from Siemens AX; Patent royalties received from GE Healthcare; L. Wang, Funding Support: NIH; COI: Microphotoacoustics; S. Cho, Yes: ;NIH/NCI grant R01CA155446 DOD/PCRP grant W81XWH-12-1-0198.« less

Real-time dynamic display of registered 4D cardiac MR and ultrasound images using a GPU

NASA Astrophysics Data System (ADS)

Zhang, Q.; Huang, X.; Eagleson, R.; Guiraudon, G.; Peters, T. M.

2007-03-01

In minimally invasive image-guided surgical interventions, different imaging modalities, such as magnetic resonance imaging (MRI), computed tomography (CT), and real-time three-dimensional (3D) ultrasound (US), can provide complementary, multi-spectral image information. Multimodality dynamic image registration is a well-established approach that permits real-time diagnostic information to be enhanced by placing lower-quality real-time images within a high quality anatomical context. For the guidance of cardiac procedures, it would be valuable to register dynamic MRI or CT with intraoperative US. However, in practice, either the high computational cost prohibits such real-time visualization of volumetric multimodal images in a real-world medical environment, or else the resulting image quality is not satisfactory for accurate guidance during the intervention. Modern graphics processing units (GPUs) provide the programmability, parallelism and increased computational precision to begin to address this problem. In this work, we first outline our research on dynamic 3D cardiac MR and US image acquisition, real-time dual-modality registration and US tracking. Then we describe image processing and optimization techniques for 4D (3D + time) cardiac image real-time rendering. We also present our multimodality 4D medical image visualization engine, which directly runs on a GPU in real-time by exploiting the advantages of the graphics hardware. In addition, techniques such as multiple transfer functions for different imaging modalities, dynamic texture binding, advanced texture sampling and multimodality image compositing are employed to facilitate the real-time display and manipulation of the registered dual-modality dynamic 3D MR and US cardiac datasets.

Multimodal nonlinear microscopy of biopsy specimen: towards intraoperative diagnostics (Conference Presentation)

NASA Astrophysics Data System (ADS)

Schmitt, Michael; Heuke, Sandro; Meyer, Tobias; Chernavskaia, Olga; Bocklitz, Thomas W.; Popp, Juergen

2016-03-01

The realization of label-free molecule specific imaging of morphology and chemical composition of tissue at subcellular spatial resolution in real time is crucial for many envisioned applications in medicine, e.g., precise surgical guidance and non-invasive histopathologic examination of tissue. Thus, new approaches for a fast and reliable in vivo and near in vivo (ex corpore in vivo) tissue characterization to supplement routine pathological diagnostics is needed. Spectroscopic imaging approaches are particularly important since they have the potential to provide a pathologist with adequate support in the form of clinically-relevant information under both ex vivo and in vivo conditions. In this contribution it is demonstrated, that multimodal nonlinear microscopy combining coherent anti-Stokes Raman scattering (CARS), two photon excited fluorescence (TPEF) and second harmonic generation (SHG) enables the detection of characteristic structures and the accompanying molecular changes of widespread diseases, particularly of cancer and atherosclerosis. The detailed images enable an objective evaluation of the tissue samples for an early diagnosis of the disease status. Increasing the spectral resolution and analyzing CARS images at multiple Raman resonances improves the chemical specificity. To facilitate handling and interpretation of the image data characteristic properties can be automatically extracted by advanced image processing algorithms, e.g., for tissue classification. Overall, the presented examples show the great potential of multimodal imaging to augment standard intraoperative clinical assessment with functional multimodal CARS/SHG/TPEF images to highlight functional activity and tumor boundaries. It ensures fast, label-free and non-invasive intraoperative tissue classification paving the way towards in vivo optical pathology.

A low-cost multimodal head-mounted display system for neuroendoscopic surgery.

PubMed

Xu, Xinghua; Zheng, Yi; Yao, Shujing; Sun, Guochen; Xu, Bainan; Chen, Xiaolei

2018-01-01

With rapid advances in technology, wearable devices as head-mounted display (HMD) have been adopted for various uses in medical science, ranging from simply aiding in fitness to assisting surgery. We aimed to investigate the feasibility and practicability of a low-cost multimodal HMD system in neuroendoscopic surgery. A multimodal HMD system, mainly consisted of a HMD with two built-in displays, an action camera, and a laptop computer displaying reconstructed medical images, was developed to assist neuroendoscopic surgery. With this intensively integrated system, the neurosurgeon could freely switch between endoscopic image, three-dimensional (3D) reconstructed virtual endoscopy images, and surrounding environment images. Using a leap motion controller, the neurosurgeon could adjust or rotate the 3D virtual endoscopic images at a distance to better understand the positional relation between lesions and normal tissues at will. A total of 21 consecutive patients with ventricular system diseases underwent neuroendoscopic surgery with the aid of this system. All operations were accomplished successfully, and no system-related complications occurred. The HMD was comfortable to wear and easy to operate. Screen resolution of the HMD was high enough for the neurosurgeon to operate carefully. With the system, the neurosurgeon might get a better comprehension on lesions by freely switching among images of different modalities. The system had a steep learning curve, which meant a quick increment of skill with it. Compared with commercially available surgical assistant instruments, this system was relatively low-cost. The multimodal HMD system is feasible, practical, helpful, and relatively cost efficient in neuroendoscopic surgery.

Muck Farming, Song Birds and Man, and Kisimi: A Curricular Case Study of the Claims of Educational Radio and Its Actualized Use in the Classroom, WKAR 1922-1945.

ERIC Educational Resources Information Center

Militello, Matthew

While its educational goals were yet to be defined, the aims of the radio in the early 1920s included the social goal of cultural pluralism; the economic goal of profiteering; the military goal of communicating, training, and surveillance; and, the political goal of propaganda and morale building. In the end, like previous technological advances,…

Electromagnetic Compatibility (EMC) Requirements for Military and Commercial Equipment

DTIC Science & Technology

2009-09-01

Commercial off-the shelf (COTS) use also provides access to what has become a much larger industrial base. With these goals in mind, the Secretary of...Band (110 – 300 GHz) 10–1 mm Microwave data links, radio astronomy , amateur radio, remote sensing, advanced weapons systems 12 Radiated EMI...to what has become a much larger industrial base. With these goals in mind, the Secretary of Defense issued a directive in June 1994 requiring the

Research in the Aloha system

NASA Technical Reports Server (NTRS)

Abramson, N.

1974-01-01

The Aloha system was studied and developed and extended to advanced forms of computer communications networks. Theoretical and simulation studies of Aloha type radio channels for use in packet switched communications networks were performed. Improved versions of the Aloha communications techniques and their extensions were tested experimentally. A packet radio repeater suitable for use with the Aloha system operational network was developed. General studies of the organization of multiprocessor systems centered on the development of the BCC 500 computer were concluded.

Radio speech communication problems reported in a survey of military pilots.

PubMed

Lahtinen, Taija M M; Huttunen, Kerttu H; Kuronen, Pentti O; Sorri, Martti J; Leino, Tuomo K

2010-12-01

Despite technological advances in conveying information, speech communication is still a key safety factor in aviation. Effective radio communication is necessary, for example, in building and maintaining good team situation awareness. However, little has been reported concerning the prevalence and nature of radio communication problems in everyday working environments in military aviation. We surveyed Finnish Defense Forces pilots regarding the prevalence of radio speech communication problems. Of the 225 pilots contacted, 75% replied to our survey. Altogether 138 of the respondents were fixed-wing pilots and 31 were helicopter pilots. Problems in radio communication occurred, on average, during 14% of flight time. The most prevalent problems were multiple speakers on the same radio frequency band causing overlapping speech, missing acknowledgments, high background noise especially during helicopter operations, and technical problems. Of the respondents, 18% (31 pilots) reported having encountered at least one potentially dangerous event caused by problems in radio communication during their military aviation career. If the employer were to offer extra hearing protection, such as custom-made ear plugs, 93% of the pilots indicated that they would use it. Communication can be a flight safety factor especially during intense air combat exercises and other information-loaded flights. During these situations, communication should be clear and focused on the most essential information. So, training and technical improvements are necessary for better communication. High quality radio speech communication also improves operational effectiveness in military aviation.

Intelligent cognitive radio jamming - a game-theoretical approach

NASA Astrophysics Data System (ADS)

Dabcevic, Kresimir; Betancourt, Alejandro; Marcenaro, Lucio; Regazzoni, Carlo S.

2014-12-01

Cognitive radio (CR) promises to be a solution for the spectrum underutilization problems. However, security issues pertaining to cognitive radio technology are still an understudied topic. One of the prevailing such issues are intelligent radio frequency (RF) jamming attacks, where adversaries are able to exploit on-the-fly reconfigurability potentials and learning mechanisms of cognitive radios in order to devise and deploy advanced jamming tactics. In this paper, we use a game-theoretical approach to analyze jamming/anti-jamming behavior between cognitive radio systems. A non-zero-sum game with incomplete information on an opponent's strategy and payoff is modelled as an extension of Markov decision process (MDP). Learning algorithms based on adaptive payoff play and fictitious play are considered. A combination of frequency hopping and power alteration is deployed as an anti-jamming scheme. A real-life software-defined radio (SDR) platform is used in order to perform measurements useful for quantifying the jamming impacts, as well as to infer relevant hardware-related properties. Results of these measurements are then used as parameters for the modelled jamming/anti-jamming game and are compared to the Nash equilibrium of the game. Simulation results indicate, among other, the benefit provided to the jammer when it is employed with the spectrum sensing algorithm in proactive frequency hopping and power alteration schemes.

Unobtrusive Multimodal Biometric Authentication: The HUMABIO Project Concept

NASA Astrophysics Data System (ADS)

Damousis, Ioannis G.; Tzovaras, Dimitrios; Bekiaris, Evangelos

2008-12-01

Human Monitoring and Authentication using Biodynamic Indicators and Behavioural Analysis (HUMABIO) (2007) is an EU Specific Targeted Research Project (STREP) where new types of biometrics are combined with state of the art sensorial technologies in order to enhance security in a wide spectrum of applications. The project aims to develop a modular, robust, multimodal biometrics security authentication and monitoring system which utilizes a biodynamic physiological profile, unique for each individual, and advancements of the state-of-the art in behavioural and other biometrics, such as face, speech, gait recognition, and seat-based anthropometrics. Several shortcomings in biometric authentication will be addressed in the course of HUMABIO which will provide the basis for improving existing sensors, develop new algorithms, and design applications, towards creating new, unobtrusive biometric authentication procedures in security sensitive, controlled environments. This paper presents the concept of this project, describes its unobtrusive authentication demonstrator, and reports some preliminary results.

Fabrication of flexible, multimodal light-emitting devices for wireless optogenetics

PubMed Central

Huang, Xian; Jung, Yei Hwan; Al-Hasani, Ream; Omenetto, Fiorenzo G.

2014-01-01

Summary The rise of optogenetics provides unique opportunities to advance materials and biomedical engineering as well as fundamental understanding in neuroscience. This protocol describes the fabrication of optoelectronic devices for studying intact neural systems. Unlike optogenetic approaches that rely on rigid fiber optics tethered to external light sources, these novel devices utilize flexible substrates to carry wirelessly powered microscale, inorganic light-emitting diodes (μ-ILEDs) and multimodal sensors inside the brain. We describe the technical procedures for construction of these devices, their corresponding radiofrequency power scavengers, and their implementation in vivo for experimental application. In total, the timeline of the procedure, including device fabrication, implantation, and preparation to begin in vivo experimentation, can be completed in approximately 3–8 weeks. Implementation of these devices allows for chronic (tested up to six months), wireless optogenetic manipulation of neural circuitry in animals experiencing behaviors such as social interaction, home cage, and other complex natural environments. PMID:24202555

Human-computer interaction for alert warning and attention allocation systems of the multimodal watchstation

NASA Astrophysics Data System (ADS)

Obermayer, Richard W.; Nugent, William A.

2000-11-01

The SPAWAR Systems Center San Diego is currently developing an advanced Multi-Modal Watchstation (MMWS); design concepts and software from this effort are intended for transition to future United States Navy surface combatants. The MMWS features multiple flat panel displays and several modes of user interaction, including voice input and output, natural language recognition, 3D audio, stylus and gestural inputs. In 1999, an extensive literature review was conducted on basic and applied research concerned with alerting and warning systems. After summarizing that literature, a human computer interaction (HCI) designer's guide was prepared to support the design of an attention allocation subsystem (AAS) for the MMWS. The resultant HCI guidelines are being applied in the design of a fully interactive AAS prototype. An overview of key findings from the literature review, a proposed design methodology with illustrative examples, and an assessment of progress made in implementing the HCI designers guide are presented.

Advanced multimodality imaging of an anomalous vessel between the ascending aorta and main pulmonary artery in a dog

PubMed Central

Markovic, Lauren E.; Kellihan, Heidi B.; Roldán-Alzate, Alejandro; Drees, Randi; Bjorling, Dale E.; Francois, Chris J.

2014-01-01

A 1-year-old male German shorthaired pointer was referred for evaluation of tachypnea and hemoptysis. A grade VI/VI left basilar continuous murmur was ausculted. Multimodality imaging consisting of thoracic radiographs, transthoracic and transesophageal echocardiography, fluoroscopy-guided selective angiography, computed tomography angiogram (CTA) and magnetic resonance angiogram (MRA), was performed on this patient. The defect included a left-to-right shunting anomalous vessel between the ascending aorta and main pulmonary artery, along with a dissecting aneurysm of the main and right pulmonary artery. An MRA postprocessing technique (PC-VIPR) was used to allow for high resolution angiographic images and further assessment of the patient’s hemodynamics prior to surgical correction. This case report describes the clinical course of a canine patient with a rare form of congenital cardiac disease, and the multiple imaging modalities that were used to aid in diagnosis and treatment. PMID:24485987

Session 21.3 - Radio and Optical Site Protection

NASA Astrophysics Data System (ADS)

Sefako, Ramotholo

2016-10-01

Advancement in radio technology means that radio astronomy has to share the radio spectrum with many other non-astronomical activities, majority of which increase radio frequency interference (RFI), and therefore detrimentally affecting the radio observations at the observatory sites. Major radio facilities such as the SKA, in both South Africa and Australia, and the Five-hundred-meter Aperture Spherical radio Telescope (FAST) in China will be very sensitive, and therefore require protection against RFI. In the case of optical astronomy, the growing urbanisation and industrialisation led to optical astronomy becoming impossible near major cities due to light and dust pollution. Major optical and IR observatories are forced to be far away in remote areas, where light pollution is not yet extreme. The same is true for radio observatories, which have to be sited away from highly RFI affected areas near populated regions and major cities. In this review, based on the Focus Meeting 21 (FM21) oral presentations at the IAU General Assembly on 11 August 2015, we give an overview of the mechanisms that have evolved to provide statutory protection for radio astronomy observing, successes (e.g at 21 cm HI line), defeats and challenges at other parts of the spectrum. We discuss the available legislative initiatives to protect the radio astronomy sites for large projects like SKA (in Australia and South Africa), and FAST against the RFI. For optical protection, we look at light pollution with examples of its effect at Xinglong observing station of the National Astronomical Observatories of China (NAOC), Ali Observatory in Tibet, and Asiago Observatory in Italy, as well as the effect of conversion from low pressure sodium lighting to LEDs in the County of Hawaii.

A radio jet from the optical and x-ray bright stellar tidal disruption flare ASASSN-14li.

PubMed

van Velzen, S; Anderson, G E; Stone, N C; Fraser, M; Wevers, T; Metzger, B D; Jonker, P G; van der Horst, A J; Staley, T D; Mendez, A J; Miller-Jones, J C A; Hodgkin, S T; Campbell, H C; Fender, R P

2016-01-01

The tidal disruption of a star by a supermassive black hole leads to a short-lived thermal flare. Despite extensive searches, radio follow-up observations of known thermal stellar tidal disruption flares (TDFs) have not yet produced a conclusive detection. We present a detection of variable radio emission from a thermal TDF, which we interpret as originating from a newly launched jet. The multiwavelength properties of the source present a natural analogy with accretion-state changes of stellar mass black holes, which suggests that all TDFs could be accompanied by a jet. In the rest frame of the TDF, our radio observations are an order of magnitude more sensitive than nearly all previous upper limits, explaining how these jets, if common, could thus far have escaped detection. Copyright © 2016, American Association for the Advancement of Science.

Training within Industry as Short-Sighted Community Literacy-Appropriate Training Program: A Case Study of Worker-Centered Training and Its Implications

ERIC Educational Resources Information Center

Remley, Dirk

2009-01-01

This essay presents a case study of the modes used in training employees at a munitions plant in Ohio between 1940 and 1945. Theories of multimodal discourse and learning advanced by The New London Group (1996), Gunther Kress and Theo Van Leeuwen (2001) and Richard Mayer (2001) inform this analysis. With an unskilled labor force and many workers…

A Search for Periodic Optical Variability in Radio Detected Ultracool Dwarfs: A Consequence of a Magnetically-Driven Auroral Process?

NASA Astrophysics Data System (ADS)

Harding, L. K.; Hallinan, G.; Boyle, R. P.; Butler, R. F.; Sheehan, B.; Golden, A.

2011-12-01

A number of ultracool dwarfs have been unexpectedly detected as radio sources in the last decade, four of which have been found to be producing periodic pulses. More recently, two of these pulsing dwarfs have also been found to be periodically variable in broadband optical photometry. The detected periods match the periods of the radio pulses which have previously been associated with the rotation period of the dwarf. For one of these objects, it has also been established that the optical and radio periodic variability are possibly linked, being a consequence of magnetically-driven auroral processes. In order to investigate the ubiquity of the periodic optical variability in radio detected sources, the GUFI instrument (Galway Ultra Fast Imager) was commissioned on the 1.8m Vatican Advanced Technology Telescope, on Mt. Graham, Arizona, and has been obtaining data for the past eighteen months. More than two hundred hours of multi-epoch photometric monitoring observations of radio detected ultracool dwarfs have been completed. We present initial results confirming optical periodic variability for four of this sample, three of which have been newly confirmed using GUFI.

Multimodal EEG Recordings, Psychometrics and Behavioural Analysis.

PubMed

Boeijinga, Peter H

2015-01-01

High spatial and temporal resolution measurements of neuronal activity are preferably combined. In an overview on how this approach can take shape, multimodal electroencephalography (EEG) is treated in 2 main parts: by experiments without a task and in the experimentally cued working brain. It concentrates first on the alpha rhythm properties and next on data-driven search for patterns such as the default mode network. The high-resolution volumic distributions of neuronal metabolic indices result in distributed cortical regions and possibly relate to numerous nuclei, observable in a non-invasive manner in the central nervous system of humans. The second part deals with paradigms in which nowadays assessment of target-related networks can align level-dependent blood oxygenation, electrical responses and behaviour, taking the temporal resolution advantages of event-related potentials. Evidence-based electrical propagation in serial tasks during performance is now to a large extent attributed to interconnected pathways, particularly chronometry-dependent ones, throughout a chain including a dorsal stream, next ventral cortical areas taking the flow of information towards inferior temporal domains. The influence of aging is documented, and results of the first multimodal studies in neuropharmacology are consistent. Finally a scope on implementation of advanced clinical applications and personalized marker strategies in neuropsychiatry is indicated. © 2016 S. Karger AG, Basel.

A new approach of building 3D visualization framework for multimodal medical images display and computed assisted diagnosis

NASA Astrophysics Data System (ADS)

Li, Zhenwei; Sun, Jianyong; Zhang, Jianguo

2012-02-01

As more and more CT/MR studies are scanning with larger volume of data sets, more and more radiologists and clinician would like using PACS WS to display and manipulate these larger data sets of images with 3D rendering features. In this paper, we proposed a design method and implantation strategy to develop 3D image display component not only with normal 3D display functions but also with multi-modal medical image fusion as well as compute-assisted diagnosis of coronary heart diseases. The 3D component has been integrated into the PACS display workstation of Shanghai Huadong Hospital, and the clinical practice showed that it is easy for radiologists and physicians to use these 3D functions such as multi-modalities' (e.g. CT, MRI, PET, SPECT) visualization, registration and fusion, and the lesion quantitative measurements. The users were satisfying with the rendering speeds and quality of 3D reconstruction. The advantages of the component include low requirements for computer hardware, easy integration, reliable performance and comfortable application experience. With this system, the radiologists and the clinicians can manipulate with 3D images easily, and use the advanced visualization tools to facilitate their work with a PACS display workstation at any time.

The Intersection of Multimodality and Critical Perspective: Multimodality as Subversion

ERIC Educational Resources Information Center

Huang, Shin-ying

2015-01-01

This study explores the relevance of multimodality to critical media literacy. It is based on the understanding that communication is intrinsically multimodal and multimodal communication is inherently social and ideological. By analysing two English-language learners' multimodal ensembles, the study reports on how multimodality contributes to a…

A high-resolution radio image of a young supernova

NASA Technical Reports Server (NTRS)

Bartel, N.; Rupen, M. P.; Shapiro, I. I.; Preston, R. A.; Rius, A.

1991-01-01

A VLBI radio images of the bright supernova 1986J, which occurred in the galaxy NGC891 at a distance of about 12 Mpc, is presented. No detailed image of any supernova or remnant has been obtained before so soon after the explosion. The image shows a shell of emission with jetlike protrusions. Analysis of the images should advance understanding of the dynamics of the expanding debris, the dissipation of energy into the surrounding circumstellar medium, and the evolution of the supernova into the remnant.

JSC Wireless Sensor Network Update

NASA Technical Reports Server (NTRS)

Wagner, Robert

2010-01-01

Sensor nodes composed of three basic components... radio module: COTS radio module implementing standardized WSN protocol; treated as WSN modem by main board main board: contains application processor (TI MSP430 microcontroller), memory, power supply; responsible for sensor data acquisition, pre-processing, and task scheduling; re-used in every application with growing library of embedded C code sensor card: contains application-specific sensors, data conditioning hardware, and any advanced hardware not built into main board (DSPs, faster A/D, etc.); requires (re-) development for each application.

Advanced structural multimodal imaging of a patient with subcortical band heterotopia.

PubMed

Kini, Lohith G; Nasrallah, Ilya M; Coto, Carlos; Ferraro, Lindsay C; Davis, Kathryn A

2016-12-01

Subcortical band heterotopia (SBH) is a disorder of neuronal migration most commonly due to mutations of the Doublecortin (DCX) gene. A range of phenotypes is seen, with most patients having some degree of epilepsy and intellectual disability. Advanced diffusion and structural magnetic resonance imaging (MRI) sequences may be useful in identifying heterotopias and dysplasias of different sizes in drug-resistant epilepsy. We describe a patient with SBH and drug-resistant epilepsy and investigate neurite density, neurite dispersion, and diffusion parameters as compared to a healthy control through the use of multiple advanced MRI modalities. Neurite density and dispersion in heterotopia was found to be more similar to white matter than gray matter. Neurite density and dispersion maps obtained using diffusion imaging may be able to better characterize different subtypes of heterotopia.

Effective multimodality treatment for advanced epidermoid carcinoma of the female genital tract

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kalra, J.; Cortes, E.; Chen, S.

1985-07-01

Fifteen patients with advanced or recurrent squamous-cell carcinoma of the cervix, vulva, vagina, and urethra were treated with simultaneous combination chemotherapy (5-fluorouracil infusion and mitomycin C) and radiotherapy (3,000 rad for a period of three weeks). Three to four weeks after completion of radiotherapy, 13 of 15 patients achieved partial or complete tumor shrinkage. Nine of 15 patients are alive, eight of whom (at a median follow-up time of 24 months) have no evidence of disease. The longest survival time was 45 + months. There was minimal toxicity associated with this therapy. The results of this pilot study suggest thatmore » the simultaneous administration of radiation and chemotherapy is an effective method of treatment of advanced female genital tract carcinoma.« less

Reader for Advanced Spoken Tamil, Parts 1 and 2.

ERIC Educational Resources Information Center

Schiffman, Harold F.

Part 1 of this reader consists of transcriptions of five Tamil radio plays, with exercises, notes, and discussion. Part 2 is a synopsis grammar and a glossary. Both are intended for advanced students of Tamil who have had at least two years of instruction in the spoken language at the college level. The materials have been tested in classroom use…

47 CFR 27.1250 - Transition of the 2150-2160/62 MHz band from the Broadband Radio Service to the Advanced Wireless...

Code of Federal Regulations, 2010 CFR

2010-10-01

... Advanced Wireless Service (AWS). The rules in this section provide for a transition period during which AWS... assigned frequencies in the 2496-2690 MHz band or other media. (a) AWS licensees and BRS licensees shall... sharing arrangement with the AWS licensee that may result in an otherwise impermissible level of...

47 CFR 27.1250 - Transition of the 2150-2160/62 MHz band from the Broadband Radio Service to the Advanced Wireless...

Code of Federal Regulations, 2011 CFR

2011-10-01

... Advanced Wireless Service (AWS). The rules in this section provide for a transition period during which AWS... assigned frequencies in the 2496-2690 MHz band or other media. (a) AWS licensees and BRS licensees shall... sharing arrangement with the AWS licensee that may result in an otherwise impermissible level of...

Network Structures for Distributed Situation Assessment

DTIC Science & Technology

1980-08-01

name a few-can contribute to the study of DAI. Presumably, DAI will advance these fields as well by providing a modeling technology suitable for precise...moreover, current SA sys- tems are highly centralized and vulnerable. Technological advances in cheap sen- sors, microprocessors, packet radio...communications, and artificial intelligence offer promising alternatives for performing military surveillance in many situations. A new approach now being

Enhanced technologies for unattended ground sensor systems

NASA Astrophysics Data System (ADS)

Hartup, David C.

2010-04-01

Progress in several technical areas is being leveraged to advantage in Unattended Ground Sensor (UGS) systems. This paper discusses advanced technologies that are appropriate for use in UGS systems. While some technologies provide evolutionary improvements, other technologies result in revolutionary performance advancements for UGS systems. Some specific technologies discussed include wireless cameras and viewers, commercial PDA-based system programmers and monitors, new materials and techniques for packaging improvements, low power cueing sensor radios, advanced long-haul terrestrial and SATCOM radios, and networked communications. Other technologies covered include advanced target detection algorithms, high pixel count cameras for license plate and facial recognition, small cameras that provide large stand-off distances, video transmissions of target activity instead of still images, sensor fusion algorithms, and control center hardware. The impact of each technology on the overall UGS system architecture is discussed, along with the advantages provided to UGS system users. Areas of analysis include required camera parameters as a function of stand-off distance for license plate and facial recognition applications, power consumption for wireless cameras and viewers, sensor fusion communication requirements, and requirements to practically implement video transmission through UGS systems. Examples of devices that have already been fielded using technology from several of these areas are given.

33 CFR 117.787 - Gowanus Canal.

Code of Federal Regulations, 2010 CFR

2010-07-01

... DRAWBRIDGE OPERATION REGULATIONS Specific Requirements New York § 117.787 Gowanus Canal. The draws of the... advance notice is given to the New York City Department of Transportation (NYCDOT), Radio Hotline, or the...

Synthesis and biological evaluation of radio and dye labeled amino functionalized dendritic polyglycerol sulfates as multivalent anti-inflammatory compounds.

PubMed

Gröger, Dominic; Paulus, Florian; Licha, Kai; Welker, Pia; Weinhart, Marie; Holzhausen, Cornelia; Mundhenk, Lars; Gruber, Achim D; Abram, Ulrich; Haag, Rainer

2013-09-18

Herein we describe a platform technology for the synthesis and characterization of partially aminated, (35)S-labeled, dendritic polyglycerol sulfate (dPG(35)S amine) and fluorescent dPGS indocarbocyanine (ICC) dye conjugates. These polymer conjugates, based on a biocompatible dendritic polyglycerol scaffold, exhibit a high affinity to inflamed tissue in vivo and represent promising candidates for therapeutic and diagnostic applications. By utilizing a one-step sequential copolymerization approach, dendritic polyglycerol (Mn ≈ 4.5 kDa) containing 9.4% N-phthalimide protected amine functionalities was prepared on a large scale. Sulfation and simultaneous radio labeling with (35)SO3 pyridine complex, followed by cleavage of the N-phthalimide protecting groups, yielded dPG(35)S amine as a beta emitting, inflammation specific probe with free amino functionalities for conjugation. Furthermore, efficient labeling procedures with ICC via iminothiolane modification and subsequent "Michael" addition of the maleimide functionalized ICC dye, as well as by amide formation via NHS derivatized ICC on a dPGS amine scaffold, are described. The dPGS-ICC conjugates were investigated with respect to their photophysical properties, and both the radiolabeled and fluorescent compounds were comparatively visualized in histological tissue sections (radio detection and fluorescence microscopy) of animals treated with dPGS. Furthermore, cellular uptake of dPGS-ICC was found in endothelial cord blood (HUVEC) and the epithelial lung cells (A549). The presented synthetic routes allow a reproducible, controlled synthesis of dPGS amine on kilogram scale applying a one-pot batch reaction process. dPGS amine can be used for analysis via radioactivity or fluorescence, thereby creating a new platform for inflammation specific, multimodal imaging purposes using other attachable probes or contrast agents.

Does order matter? Investigating the effect of sequence on glance duration during on-road driving

PubMed Central

Roberts, Shannon C.; Reimer, Bryan; Mehler, Bruce

2017-01-01

Previous literature has shown that vehicle crash risks increases as drivers’ off-road glance duration increases. Many factors influence drivers’ glance duration such as individual differences, driving environment, or task characteristics. Theories and past studies suggest that glance duration increases as the task progresses, but the exact relationship between glance sequence and glance durations is not fully understood. The purpose of this study was to examine the effect of glance sequence on glance duration among drivers completing a visual-manual radio tuning task and an auditory-vocal based multi-modal navigation entry task. Eighty participants drove a vehicle on urban highways while completing radio tuning and navigation entry tasks. Forty participants drove under an experimental protocol that required three button presses followed by rotation of a tuning knob to complete the radio tuning task while the other forty participants completed the task with one less button press. Multiple statistical analyses were conducted to measure the effect of glance sequence on glance duration. Results showed that across both tasks and a variety of statistical tests, glance sequence had inconsistent effects on glance duration—the effects varied according to the number of glances, task type, and data set that was being evaluated. Results suggest that other aspects of the task as well as interface design effect glance duration and should be considered in the context of examining driver attention or lack thereof. All in all, interface design and task characteristics have a more influential impact on glance duration than glance sequence, suggesting that classical design considerations impacting driver attention, such as the size and location of buttons, remain fundamental in designing in-vehicle interfaces. PMID:28158301

Surface Accuracy and Pointing Error Prediction of a 32 m Diameter Class Radio Astronomy Telescope

NASA Astrophysics Data System (ADS)

Azankpo, Severin

2017-03-01

The African Very-long-baseline interferometry Network (AVN) is a joint project between South Africa and eight partner African countries aimed at establishing a VLBI (Very-Long-Baseline Interferometry) capable network of radio telescopes across the African continent. An existing structure that is earmarked for this project, is a 32 m diameter antenna located in Ghana that has become obsolete due to advances in telecommunication. The first phase of the conversion of this Ghana antenna into a radio astronomy telescope is to upgrade the antenna to observe at 5 GHz to 6.7 GHz frequency and then later to 18 GHz within a required performing tolerance. The surface and pointing accuracies for a radio telescope are much more stringent than that of a telecommunication antenna. The mechanical pointing accuracy of such telescopes is influenced by factors such as mechanical alignment, structural deformation, and servo drive train errors. The current research investigates the numerical simulation of the surface and pointing accuracies of the Ghana 32 m diameter radio astronomy telescope due to its structural deformation mainly influenced by gravity, wind and thermal loads.

Can exercise suppress tumour growth in advanced prostate cancer patients with sclerotic bone metastases? A randomised, controlled study protocol examining feasibility, safety and efficacy

PubMed Central

Newton, Robert U; Spry, Nigel A; Taaffe, Dennis R; Chambers, Suzanne K; Feeney, Kynan T; Joseph, David J; Redfern, Andrew D; Ferguson, Tom; Galvão, Daniel A

2017-01-01

Introduction Exercise may positively alter tumour biology through numerous modulatory and regulatory mechanisms in response to a variety of modes and dosages, evidenced in preclinical models to date. Specifically, localised and systemic biochemical alterations produced during and following exercise may suppress tumour formation, growth and distribution by virtue of altered epigenetics and endocrine–paracrine activity. Given the impressive ability of targeted mechanical loading to interfere with metastasis-driven tumour formation in human osteolytic tumour cells, it is of equal interest to determine whether a similar effect is observed in sclerotic tumour cells. The study aims to (1) establish the feasibility and safety of a combined modular multimodal exercise programme with spinal isometric training in advanced prostate cancer patients with sclerotic bone metastases and (2) examine whether targeted and supervised exercise can suppress sclerotic tumour growth and activity in spinal metastases in humans. Methods and analysis A single-blinded, two-armed, randomised, controlled and explorative phase I clinical trial combining spinal isometric training with a modular multimodal exercise programme in 40 men with advanced prostate cancer and stable sclerotic spinal metastases. Participants will be randomly assigned to (1) the exercise intervention or (2) usual medical care. The intervention arm will receive a 3-month, supervised and individually tailored modular multimodal exercise programme with spinal isometric training. Primary endpoints (feasibility and safety) and secondary endpoints (tumour morphology; biomarker activity; anthropometry; musculoskeletal health; adiposity; physical function; quality of life; anxiety; distress; fatigue; insomnia; physical activity levels) will be measured at baseline and following the intervention. Statistical analyses will include descriptive characteristics, t-tests, effect sizes and two-way (group × time) repeated-measures analysis of variance (or analysis of covariance) to examine differences between groups over time. The data-set will be primarily examined using an intention-to-treat approach with multiple imputations, followed by a secondary sensitivity analysis to ensure data robustness using a complete cases approach. Ethics and dissemination Ethics approval was obtained from the Human Research Ethics Committee (HREC) of Edith Cowan University and the Sir Charles Gairdner and Osborne Park Health Care Group. If proven to be feasible and safe, this study will form the basis of future phase II and III trials in human patients with advanced cancer. To reach a maximum number of clinicians, practitioners, patients and scientists, outcomes will be disseminated through national and international clinical, conference and patient presentations, as well as publication in high-impact, peer-reviewed academic journals. Trial registration number ACTRN 12616000179437. PMID:28559456

Interference-Detection Module in a Digital Radar Receiver

NASA Technical Reports Server (NTRS)

Fischman, Mark; Berkun, Andrew; Chu, Anhua; Freedman, Adam; Jourdan, Michael; McWatters, Dalia; Paller, Mimi

2009-01-01

A digital receiver in a 1.26-GHz spaceborne radar scatterometer now undergoing development includes a module for detecting radio-frequency interference (RFI) that could contaminate scientific data intended to be acquired by the scatterometer. The role of the RFI-detection module is to identify time intervals during which the received signal is likely to be contaminated by RFI and thereby to enable exclusion, from further scientific data processing, of signal data acquired during those intervals. The underlying concepts of detection of RFI and rejection of RFI-contaminated signal data are also potentially applicable in advanced terrestrial radio receivers, including software-defined radio receivers in general, receivers in cellular telephones and other wireless consumer electronic devices, and receivers in automotive collision-avoidance radar systems.

The utility of high-resolution intraoperative MRI in endoscopic transsphenoidal surgery for pituitary macroadenomas: early experience in the Advanced Multimodality Image Guided Operating suite

PubMed Central

Zaidi, Hasan A.; De Los Reyes, Kenneth; Barkhoudarian, Garni; Litvack, Zachary N.; Bi, Wenya Linda; Rincon-Torroella, Jordina; Mukundan, Srinivasan; Dunn, Ian F.; Laws, Edward R.

2016-01-01

Objective Endoscopic skull base surgery has become increasingly popular among the skull base surgery community, with improved illumination and angled visualization potentially improving tumor resection rates. Intraoperative MRI (iMRI) is used to detect residual disease during the course of the resection. This study is an investigation of the utility of 3-T iMRI in combination with transnasal endoscopy with regard to gross-total resection (GTR) of pituitary macroadenomas. Methods The authors retrospectively reviewed all endoscopic transsphenoidal operations performed in the Advanced Multimodality Image Guided Operating (AMIGO) suite from November 2011 to December 2014. Inclusion criteria were patients harboring presumed pituitary macroadenomas with optic nerve or chiasmal compression and visual loss, operated on by a single surgeon. Results Of the 27 patients who underwent transsphenoidal resection in the AMIGO suite, 20 patients met the inclusion criteria. The endoscope alone, without the use of iMRI, would have correctly predicted 13 (65%) of 20 cases. Gross-total resection was achieved in 12 patients (60%) prior to MRI. Intraoperative MRI helped convert 1 STR and 4 NTRs to GTRs, increasing the number of GTRs from 12 (60%) to 16 (80%). Conclusions Despite advances in visualization provided by the endoscope, the incidence of residual disease can potentially place the patient at risk for additional surgery. The authors found that iMRI can be useful in detecting unexpected residual tumor. The cost-effectiveness of this tool is yet to be determined. PMID:26926058

Surgical resection after TNFerade therapy for locally advanced pancreatic cancer.

PubMed

Chadha, Manpreet K; Litwin, Alan; Levea, Charles; Iyer, Renuka; Yang, Gary; Javle, Milind; Gibbs, John F

2009-09-04

Treatment of pancreatic cancer remains a major oncological challenge and survival is dismal. Most patients, present with advanced disease at diagnosis and are not candidates for curative resection. Preoperative chemoradiation may downstage and improve survival in locally advanced pancreatic cancer. This has prompted investigators to look for novel neoadjuvant therapies. Gene therapy for pancreatic cancer is a novel investigational approach that may have promise. TNFerade is a replication deficient adenovirus vector carrying the human tumor necrosis factor (TNF)-alpha gene regulated under control of a radiation-inducible gene promoter. Transfection of tumor cells with TNFerade maximizes the antitumor effect of TNF-alpha under influence of radiation leading to synergistic effects in preclinical studies. We describe a case of locally advanced unresectable pancreatic cancer treated with a novel multimodal approach utilizing gene therapy with TNFerade and concurrent chemoradiation that was followed by successful surgical resection. Neoadjuvant TNFerade based chemoradiation therapy may be a useful adjunct to treatment of locally advanced pancreatic cancer.

Trends in Performance and Characteristics of Ultra-Stable Oscillators for Deep Space Radio Science Experiments

NASA Technical Reports Server (NTRS)

Asmar, Sami

1997-01-01

Telecommunication systems of spacecraft on deep space missions also function as instruments for Radio Science experiments. Radio scientists utilize the telecommunication links between spacecraft and Earth to examine very small changes in the phase/frequency, amplitude, and/or polarization of radio signals to investigate a host of physical phenomena in the solar system. Several missions augmented the radio communication system with an Ultra-Stable Oscillator (USO) in order to provide a highly stable reference signal for oneway downlink. This configuration is used in order to enable better investigations of the atmospheres of the planets occulting the line-of-sight to the spacecraft; one-way communication was required and the transponders' built-in auxiliary oscillators were neither sufficiently stable nor spectrally pure for the occultation experiments. Since Radio Science instrumentation is distributed between the spacecraft and the ground stations, the Deep Space Network (DSN) is also equipped to function as a world-class instrument for Radio Science research. For a detailed account of Radio Science experiments, methodology, key discoveries, and the DSN's historical contribution to the field, see Asmar and Renzetti (1993). The tools of Radio Science can be and have also been utilized in addressing several mission engineering challenges; e.g., characterization of spacecraft nutation and anomalous motion, antenna calibrations, and communications during surface landing phases. Since the first quartz USO was flown on Voyager, the technology has advanced significantly, affording future missions higher sensitivity in reconstructing the temperature pressure profiles of the atmospheres under study as well as other physical phenomena of interest to Radio Science. This paper surveys the trends in stability and spectral purity performance, design characteristics including size and mass, as well as cost and history of these clocks in space.

Electron densities in the ionosphere of Mars: A comparison of MARSIS and radio occultation measurements

NASA Astrophysics Data System (ADS)

Vogt, Marissa F.; Withers, Paul; Fallows, Kathryn; Flynn, Casey L.; Andrews, David J.; Duru, Firdevs; Morgan, David D.

2016-10-01

Radio occultation electron densities measurements from the Mariner 9 and Viking spacecraft, which orbited Mars in the 1970s, have recently become available in a digital format. These data are highly complementary to the radio occultation electron density profiles from Mars Global Surveyor, which were restricted in solar zenith angle and altitude. We have compiled data from the Mariner 9, Viking, and Mars Global Surveyor radio occultation experiments for comparison to electron density measurements made by Mars Advanced Radar for Subsurface and Ionosphere Sounding (MARSIS), the topside radar sounder on Mars Express, and MARSIS-based empirical density models. We find that the electron densities measured by radio occultation are in generally good agreement with the MARSIS data and model, especially near the altitude of the peak electron density but that the MARSIS data and model display a larger plasma scale height than the radio occultation profiles at altitudes between the peak density and 200 km. Consequently, the MARSIS-measured and model electron densities are consistently larger than radio occultation densities at altitudes 200-300 km. Finally, we have analyzed transitions in the topside ionosphere, at the boundary between the photochemically controlled and transport-controlled regions, and identified the average transition altitude, or altitude at which a change in scale height occurs. The average transition altitude is 200 km in the Mariner 9 and Viking radio occultation profiles and in profiles of the median MARSIS radar sounding electron densities.

Collaborative visual analytics of radio surveys in the Big Data era

NASA Astrophysics Data System (ADS)

Vohl, Dany; Fluke, Christopher J.; Hassan, Amr H.; Barnes, David G.; Kilborn, Virginia A.

2017-06-01

Radio survey datasets comprise an increasing number of individual observations stored as sets of multidimensional data. In large survey projects, astronomers commonly face limitations regarding: 1) interactive visual analytics of sufficiently large subsets of data; 2) synchronous and asynchronous collaboration; and 3) documentation of the discovery workflow. To support collaborative data inquiry, we present encube, a large-scale comparative visual analytics framework. encube can utilise advanced visualization environments such as the CAVE2 (a hybrid 2D and 3D virtual reality environment powered with a 100 Tflop/s GPU-based supercomputer and 84 million pixels) for collaborative analysis of large subsets of data from radio surveys. It can also run on standard desktops, providing a capable visual analytics experience across the display ecology. encube is composed of four primary units enabling compute-intensive processing, advanced visualisation, dynamic interaction, parallel data query, along with data management. Its modularity will make it simple to incorporate astronomical analysis packages and Virtual Observatory capabilities developed within our community. We discuss how encube builds a bridge between high-end display systems (such as CAVE2) and the classical desktop, preserving all traces of the work completed on either platform - allowing the research process to continue wherever you are.

The Telecommunications and Data Acquisition Report

NASA Technical Reports Server (NTRS)

Posner, E. C. (Editor)

1989-01-01

Deep Space Network advanced systems, very large scale integration architecture for decoders, radar interface and control units, microwave time delays, microwave antenna holography, and a radio frequency interference survey are among the topics discussed.

Wideband spectrum analysis of ultra-high frequency radio-wave signals due to advanced one-phonon non-collinear anomalous light scattering.

PubMed

Shcherbakov, Alexandre S; Arellanes, Adan Omar

2017-04-20

We present a principally new acousto-optical cell providing an advanced wideband spectrum analysis of ultra-high frequency radio-wave signals. For the first time, we apply a recently developed approach with the tilt angle to a one-phonon non-collinear anomalous light scattering. In contrast to earlier cases, now one can exploit a regime with the fixed optical wavelength for processing a great number of acoustic frequencies simultaneously in the linear regime. The chosen rutile-crystal combines a moderate acoustic velocity with low acoustic attenuation and allows us wide-band data processing within GHz-frequency acoustic waves. We have created and experimentally tested a 6-cm aperture rutile-made acousto-optical cell providing the central frequency 2.0 GHz, frequency bandwidth ∼0.52  GHz with the frequency resolution about 68.3 kHz, and ∼7620 resolvable spots. A similar cell permits designing an advanced ultra-high-frequency arm within a recently developed multi-band radio-wave acousto-optical spectrometer for astrophysical studies. This spectrometer is intended to operate with a few parallel optical arms for processing the multi-frequency data flows within astrophysical observations. Keeping all the instrument's advantages of the previous schematic arrangement, now one can create the highest-frequency arm using the developed rutile-based acousto-optical cell. It permits optimizing the performances inherent in that arm via regulation of both the central frequency and the frequency bandwidth for spectrum analysis.

Integrative Data Analysis of Multi-Platform Cancer Data with a Multimodal Deep Learning Approach.

PubMed

Liang, Muxuan; Li, Zhizhong; Chen, Ting; Zeng, Jianyang

2015-01-01

Identification of cancer subtypes plays an important role in revealing useful insights into disease pathogenesis and advancing personalized therapy. The recent development of high-throughput sequencing technologies has enabled the rapid collection of multi-platform genomic data (e.g., gene expression, miRNA expression, and DNA methylation) for the same set of tumor samples. Although numerous integrative clustering approaches have been developed to analyze cancer data, few of them are particularly designed to exploit both deep intrinsic statistical properties of each input modality and complex cross-modality correlations among multi-platform input data. In this paper, we propose a new machine learning model, called multimodal deep belief network (DBN), to cluster cancer patients from multi-platform observation data. In our integrative clustering framework, relationships among inherent features of each single modality are first encoded into multiple layers of hidden variables, and then a joint latent model is employed to fuse common features derived from multiple input modalities. A practical learning algorithm, called contrastive divergence (CD), is applied to infer the parameters of our multimodal DBN model in an unsupervised manner. Tests on two available cancer datasets show that our integrative data analysis approach can effectively extract a unified representation of latent features to capture both intra- and cross-modality correlations, and identify meaningful disease subtypes from multi-platform cancer data. In addition, our approach can identify key genes and miRNAs that may play distinct roles in the pathogenesis of different cancer subtypes. Among those key miRNAs, we found that the expression level of miR-29a is highly correlated with survival time in ovarian cancer patients. These results indicate that our multimodal DBN based data analysis approach may have practical applications in cancer pathogenesis studies and provide useful guidelines for personalized cancer therapy.

Reactivity-controlled compression ignition drive cycle emissions and fuel economy estimations using vehicle system simulations

DOE PAGES

Curran, Scott J.; Gao, Zhiming; Wagner, Robert M.

2014-12-22

In-cylinder blending of gasoline and diesel to achieve reactivity-controlled compression ignition has been shown to reduce NO X and soot emissions while maintaining or improving brake thermal efficiency as compared with conventional diesel combustion. The reactivity-controlled compression ignition concept has an advantage over many advanced combustion strategies in that the fuel reactivity can be tailored to the engine speed and load, allowing stable low-temperature combustion to be extended over more of the light-duty drive cycle load range. In this paper, a multi-mode reactivity-controlled compression ignition strategy is employed where the engine switches from reactivity-controlled compression ignition to conventional diesel combustionmore » when speed and load demand are outside of the experimentally determined reactivity-controlled compression ignition range. The potential for reactivity-controlled compression ignition to reduce drive cycle fuel economy and emissions is not clearly understood and is explored here by simulating the fuel economy and emissions for a multi-mode reactivity-controlled compression ignition–enabled vehicle operating over a variety of US drive cycles using experimental engine maps for multi-mode reactivity-controlled compression ignition, conventional diesel combustion, and a 2009 port-fuel injected gasoline engine. Drive cycle simulations are completed assuming a conventional mid-size passenger vehicle with an automatic transmission. Multi-mode reactivity-controlled compression ignition fuel economy simulation results are compared with the same vehicle powered by a representative 2009 port-fuel injected gasoline engine over multiple drive cycles. Finally, engine-out drive cycle emissions are compared with conventional diesel combustion, and observations regarding relative gasoline and diesel tank sizes needed for the various drive cycles are also summarized.« less

View of Soviet ionospheric modification research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duncan, L.M.; Showen, R.L.

1990-10-01

We have reviewed and provided a technical assessment of Soviet research of the past five to ten years in ionospheric modification by high-power radio waves. This review includes a comprehensive survey of Soviet published literature, conference proceedings, and direct discussions with the involved Soviet researchers. The current state of the art for Soviet research in this field is evaluated, identifying areas of potential breakthrough discoveries, and discussing implications of this work for emerging technologies and future applications. This assessment is divided into the categories of basic research, advanced research, and applications. Basic research is further subdivided into studies of themore » modified natural geophysical environment, nonlinear plasma physics, and polar geophysical studies. Advanced research topics include the generation of artificial ionization mirrors and high-power oblique propagation effects. A separate comparative assessment of Soviet theoretical work also is included in this analysis. Our evaluation of practical and potential applications of this research discusses the utility of ionospheric modification in creating disturbed radio wave propagation environments, and its role in current and future remote-sensing and telecommunications systems. This technical assessment does not include consideration of ionospheric modification by means other than high-power radio waves. The Soviet effort in ionospheric modification sustains theoretical and experimental research at activity levels considerably greater than that found in comparable programs in the West. Notable strengths of the Soviet program are its breadth of coverage, large numbers of scientific participation, theoretical creativity and insight, and its powerful radio wave transmitting facilities.« less

Rocket-Based Combined-Cycle (RBCC) Propulsion Technology Workshop. Tutorial session

NASA Technical Reports Server (NTRS)

1992-01-01

The goal of this workshop was to illuminate the nation's space transportation and propulsion engineering community on the potential of hypersonic combined cycle (airbreathing/rocket) propulsion systems for future space transportation applications. Four general topics were examined: (1) selections from the expansive advanced propulsion archival resource; (2) related propulsion systems technical backgrounds; (3) RBCC engine multimode operations related subsystem background; and (4) focused review of propulsion aspects of current related programs.

Coexistencia e integracion de comunicaciones inalambricas en sistemas de transmision opticos

NASA Astrophysics Data System (ADS)

Perez Soler, Joaquin

Current network and telecommunication systems are required to provide higher data rates in access networks to an increasing number of users. This fact is mainly due to the increase in the Internet traffic data, which is related with the higher demand of online videogames and software, the increased complexity in the content of web pages, the joint distribution of audio-visual and added-value online content, and the introduction of high-definition services and contents such as video on demand, as a result of a society increasingly more interconnected. In order to satisfy these higher data rates requirements, new techniques for the joint distribution of several wireless communication systems are proposed in this Thesis. The aim of these techniques is to facilitate the deployment of an integrated access network at the customer premises, enabling the integration of optical transmission over an optical access network and radio-frequency transmission in the same infrastructure. Two main wireless communication systems are considered in this Thesis, WiMAX (Worldwide Interoperability for Microwave Access) and UWB (Ultra-Wide Band) according to WiMedia Alliance recommendation. Comparing the bit rate and expected range, WiMAX and UWB are complementary radio technologies expected to coexist in a near future in integrated access networks. The optical access network considered in this Thesis can be regarded as a FTTH network (Fibre-to-the-Home). The wireless signals are natively transmitted over optical network, that is, without frequency upconversion and remodulation stages, over one or several optical carriers. This technology, which is known as Radio-over-Fibre (RoF), is well suited for integrated access networks. First, the requirements for the wireless convergence of services based on Multi-Band Orthogonal-Frequency Division-Multiplexing UWB (MB-OFDM UWB) and WiMAX 802.16e in Wireless Personal Area Networks (WPAN) are stated. The aim of this study is to provide relevant protection margins in order to ensure the coexistence between both technologies. The obtained protection margins are of great interest for the development of advanced interference mitigation techniques such as DAA (Detect-and-Avoid), in the framework of future cognitive radio technologies. In a second step, the wireless coexistence of MB-OFDM UWB and WiMAX technologies is analyzed from the point of view of access networks based on RoF systems. Two experimental field trials are here carried out. In the first one, the wireless convergence is evaluated in a multi-mode fibre RoF system, whereas in the second one, the RoF system is based on a standard single-mode fibre. These experimental results provide relevant fibre link transmission distances to enable the deployment of RoF networks. Moreover, a new optical transmission technique based on polarization division multiplexing is proposed and experimentally evaluated in order to ensure the wireless coexistence in RoF systems. Finally, the impact of the electro-optical Mach-Zehnder modulator is analyzed, since the dynamic range of this device limits the performance of the RoF system. Moreover, a new optical linearization technique for Mach-Zehnder modulators is proposed and evaluated in order to overcome this limitation.

Impact of HPV 16/18 infection on clinical outcomes in locally advanced cervical cancers treated with radical radio (chemo) therapy - A prospective observational study.

PubMed

Mahantshetty, Umesh; Teni, Tanuja; Naga, Pushpa; Hotwani, Chandni; Umesh, Sumuki; Kannan, Sadhana; Hande, Vinod; Pawar, Sagar; Engineer, Reena; Chopra, Supriya; Deodhar, Kedar; Maheshwari, Amita; Gurram, Lavanya; Gupta, Sudeep; Shrivastava, Shyam Kishore

2018-02-01

With an aim to investigate the impact of Human Papilloma Virus (HPV) 16/18 infection on clinical outcomes in locally advanced cervical cancers treated with radical radio (chemo) therapy, we undertook this prospective study. Between May 2010 and April 2012, 150 histologically proven cervical cancer patients treated with radio (chemo) therapy were accrued. Cervical biopsies/brushings were collected at pre-treatment, end of treatment and at 3 monthly intervals up to 24months. Quantitative estimation of HPV 16/18 was done using real-time polymerase chain reaction (RT-PCR) and correlated with various clinical end-points. Out of 150 patients accrued, 135 patients were considered for final analysis. Pre-treatment HPV16/18 DNA was detected in 126 (93%) patients, with HPV-16 present in 91%. The mean log (±SD) HPV-16 and HPV-18 viral load at pre-treatment was 4.76 (±2.5) and 0.14 (±2.1) copies/10ng of DNA, respectively. Though significant decline in viral load was observed on follow-ups (p<0.0001); by 9-month follow-up, 89 (66%) patients had persistence of HPV infection. Patients with persistent HPV 16/18 infection had a significantly higher overall and loco-regional relapses [44/89 (49%) and 29/89 (32%)] as compared to HPV clearance by 9months [12/43 (28%) and 5/43 (11%)] with p=0.024 and p=0.02, respectively. Also, persistent HPV infection by 24-month showed a significant impact on loco-regional control (LRC) and recurrence-free survival (RFS). In locally advanced cervical cancers treated with radical radio (chemo) therapy, persistent HPV 16/18 infection is significantly high in immediate post-treatment period and correlated with higher loco-regional, overall relapses and was also associated with early relapses. Copyright © 2017 Elsevier Inc. All rights reserved.

Effects of radio frequency identification-related radiation on in vitro biologics.

PubMed

Uysal, Ismail; Hohberger, Clive; Rasmussen, R Scott; Ulrich, David A; Emond, Jean-Pierre; Gutierrez, Alfonso

2012-01-01

The recent developments on the use of e-pedigree to identify the chain of custody of drugs suggests the use of advanced track and trace technologies such as two-dimensional barcodes and radio frequency identification (RFID) tags. RFID technology is used mainly for valuable commodities such as pharmaceutical products while incorporating additional functionalities like monitoring environmental variables to ensure product safety and quality. In its guidance for the use of RFID technologies for drugs (Compliance Policy Guide Section 400.210), the Food and Drug Administration outlined multiple parameters that would apply to any study or application using RFID. However, drugs approved under a Biologics License Application or protein drugs covered by a New Drug Application were excluded mainly due to concerns about the effects of radio frequency radiation (thermal and/or non-thermal) on biologics. Even though the thermal effects of radio frequency on biologics are relatively well understood, there are few studies in the literature about the non-thermal effects of radio frequency with regards to the protein structure integrity. In this paper, we analyze the non-thermal effects of radio frequency radiation by exposing a wide variety of biologics including biopharmaceuticals with vaccines, hormones, and immunoglobulins, as well as cellular blood products such as red blood cells and whole blood-derived platelets as well as fresh frozen plasma. In order to represent the majority of the frequency spectrum used in RFID applications, five different frequencies (13.56 MHz, 433 MHz, 868 MHz, 915 MHz, and 2.4 GHz) are used to account for the most commonly used international frequency bands for RFID. With the help of specialized radio frequency signal-generating hardware, magnetic and electromagnetic fields are created around the exposed products with power levels greater than Federal Communications Commission-regulated limits. The in vitro test results on more than 100 biopharmaceutical products from eight major pharmaceutical companies as well, as different blood products, show no non-thermal effect by radio frequency radiation. Forthcoming requirements, such as the California Board of Pharmacy Track and Trace initiative regarding the use of e-pedigree to identify the chain of custody of drugs, suggest the use of advanced track and trace technologies such as two-dimensional barcodes and radio frequency identification (RFID) tags. When used for pharmaceuticals, RFID technology can support additional functionalities like monitoring temperature to ensure product safety. In its guidance for the use of RFID technologies for drugs, the Food and Drug Administration outlined multiple parameters that would apply to pilot studies using RFID while excluding drugs approved under a Biologics License Application or protein drugs covered by a New Drug Application due to concerns about the effects of radio frequency radiation on biologics. Even though the effects of radio frequency on biologics due to temperature changes are relatively well understood, there are few studies in the literature about other effects of radio frequency that can occur without a noticeable change in temperature. In this paper, we expose a wide variety of biologics including biopharmaceuticals to radio frequency radiation at different frequencies, as well as cellular blood products and plasma to high frequency radiation. The in vitro test results show no detectable effect due to radio frequency radiation.

33 CFR 117.789 - Harlem River.

Code of Federal Regulations, 2010 CFR

2010-07-01

... OPERATION REGULATIONS Specific Requirements New York § 117.789 Harlem River. (a) The draws of all railroad... signal if at least a four-hour advance notice is given to the New York City Highway Radio (Hotline) Room...

Railroad communications and train control : report to Congress

DOT National Transportation Integrated Search

1994-07-01

Recent tragedies in the railroad industry have again focused attention on the prospects for : improving railroad safety through enhanced radio communication and implementation of : advanced train control systems (ATCS). ATCS has the potential to prev...

Witnessing the Gradual Slowdown of Powerful Extragalactic Jets: The X-Ray-Optical-Radio Connection

NASA Technical Reports Server (NTRS)

Georganopoulos, Markos; Kazanas, Demosthenes

2004-01-01

A puzzling feature of the Chandra-detected quasar jets is that their X-ray emission decreases faster along the jet than their radio emission, resulting from an outward-increasing radio-to-X-ray ratio. In some sources this behavior is so extreme that the radio emission peak is located clearly downstream of that of the X-rays. This is a rather unanticipated behavior given that the inverse Compton nature of the X-rays and the synchrotron radio emission are attributed to roughly the same electrons of the jet's nonthermal electron distribution. In this letter we show that this morphological behavior can result from the gradual deceleration of a relativistic flow and that the offsets in peak emission at different wavelengths carry the imprint of this deceleration. This notion is consistent with another recent finding, namely, that the jets feeding the terminal hot spots of powerful radio galaxies and quasars are still relativistic with Lorentz factors GAMMA approximately 2-3. The picture of the kinematics of powerful jets emerging from these considerations is that they remain relativistic as they gradually decelerate from kiloparsec scales to the hot spots, where, in a final collision with the intergalactic medium, they slow down rapidly to the subrelativistic velocities of the hot spot advance speed.

[The longsurvivors for non-small cell lung cancer: remarks on the present and in perspective].

PubMed

Salvati, F; Signora, M; Cardillo, G

2015-01-01

The Authors fully share cricitisms voiced in international literature to NSCLC longsurvivors, in particular those remarkes related to advanced disease patients following various anti-tumor treatments ( mostly multimodal). To this point, even the NCCN version 3.2014 guidelines prove inadequate as they mostly focus on longsurvivors post-NSCLC early stage surgical resection. Although AIOM Working Group's recommendations for follow-up seem to be more adequate, still they lack depth with respect to advanced-stage bronchogenic carcinoma. The Authors quote a number of case report related to advanced disease longsurvivors, and draws his attention on the peculiar role of pneumologists in the follow-up for such patients: in particular, as regards respiratory pathologies prior or subsequent to different anti-tumor treatments (i.e., BPCO, interstitial lung diseases, pulmonary thromboembolism, etc.).

Preface

NASA Astrophysics Data System (ADS)

Gurvits, L. I.; Frey, S.; Rawlings, S.

Three quarters of the century has passed since the synergy between scientific discovery and technological advances enabled Karl Jansky to open a new window on the Universe, marking the birth of radio astronomy. Since then, radio astronomy has become one of the major tools for studying the Universe. Radio galaxies with their enormously energetic clouds of relativistic electrons and cosmic jets that extend up to millions of light years into space, a broad variety of atoms and molecules, from neutral hydrogen to complex organic conglomerates, cosmic microwave masers, the cosmic microwave background radiation, quasars, pulsars, gravitational lenses and extra-solar planetary systems were all discovered in radio domain. Radio telescopes have also been used to measure the relativistic bending of electromagnetic waves which pass near the limb of the Sun, to establish the existence of gravitational radiation and measure continental drift. The progress of radio astronomy is driven by the needs of fundamental science and is based on the state-of-the-art developments in technology. Since its first steps, radio astronomy has made huge progress, resulting in the improvement of sensitivity by many orders of magnitude and approaching micro-arcsecond angular resolution. This progress will continue in the XXI century with the advent of new radio astronomy facilities on the ground (LOFAR, ALMA, SKA) and in space (Planck, next generation space VLBI systems). In this book, the current state of radio astronomy is framed by several retrospective reviews and introductions to the next generation facilities. Views at radio astronomy from other domains, optical astronomy and high energy astrophysics, are also presented. Advances of modern radio astronomy were in the focus of the symposium “Radio Astronomy at 70: from Karl Jansky to microjansky”, which was held under the auspices of the annual Joint European National Astronomy Meeting (JENAM) in Budapest, Hungary, 27-30 August 2003. More than 30 contributed papers from that symposium have been published recently in Baltic Astronomy (2005, Vol. 14, No. 3). This book contains a set of invited review presentations given at the symposium. They cover a range of scientific topics in extragalactic and galactic radio astronomy studies as well as recent developments in radio astronomy techniques aimed at the next generation radio astronomy facilities. On behalf of the organisers and participants of the symposium, we express our gratitude to the sponsors of the event and this publication: the European Astronomical Society, Hungarian Academy of Sciences, Eötvös Loránd University, Konkoly Observatory, Eötvös Loránd Physical Society, Netherlands Foundation for Research in Astronomy (ASTRON), Joint Institute for VLBI in Europe, Hungarian Scientific Research Fund, EC FP5 Infrastructure Cooperation Network RadioNET and EC FP6 Integrated Infrastructure Initiative RadioNet. We are grateful to the members of the Scientific Organising Committee of the Symposium. Ken Kellermann made very useful remarks on several papers. Ellen Bouton and Pat Smiley helped to include in this book several photos from the AUI-NRAO archive. Mark Bentum designed the cover picture of the book, visual components for which were kindly supplied by W.A. Baan, M.F. Bietenholz, R. Boomsma, R. Braun, N. Bartel, M.A. Garrett, J.M. van der Hulst, H.R. Klockner, NASA/WMAP Science Team, T.A. Oosterloo, M.P. Rupen, R. Sancisi, B. Stappers, R.G. Strom, D.A. Thilker, and R.A.M. Walterbos. Most of all, we are grateful to all the authors of this book for their efforts in the increasingly old-fashioned art of writing papers for a real “paper” publication as opposed to putting powerpoint files on a web site. We do hope that their nice work will be appreciated by the readers. Leonid Gurvits, Dwingeloo, The Netherlands Sándor Frey, Budapest, Hungary Steve Rawlings, Oxford, UK

Solar-Geophysical Data Number 497, January 1986. Part 1: (Prompt reports). Date for December 1985, November 1985 and late data

NASA Technical Reports Server (NTRS)

Coffey, H. E.

1986-01-01

Solar-Geophysical Data Number 497, January 1986, Part 1 (prompt reports); Data for December 1985, November 1985 and Late Data contains the Data for December 1985-(IUWDS alert periods (advance and worldwide), solar activity indices, Solar flares, Vostok inferred interplanetary magnetic field polarity, Stanford mean solar magnetic field); data for November 1985-(solar active regions, sudden ionospheric disturbances, solar radio spectral observations, cosmic ray measurements by neutron monitor, geomagnetic indices, radio propagation indices); and late data-(geomagnetic indices, calcium plage data).

Advanced teleprocessing systems

NASA Astrophysics Data System (ADS)

Kleinrock, L.; Gerla, M.

1983-03-01

This Semi-Annual Technical Report covers research covering the period from October 1, 1982 to March 31, 1983. This contract has three primary designated research areas: packet radio systems, resource sharing and allocation, and distributed processing and control. This report contains abstracts of publications which summarize research results in these areas followed by the main body of the report which is devoted to a treatment of single- and multi-hop packet radio systems. In particular, the main body consists of a Ph.D. dissertation, Analysis of Throughput and Delay for Single- and Multi-Hop Packet Radio Networks. The work presents a new approach to evaluating the performance of multi-hop packet radio networks, namely, a study of the times between successful transmissions. Also studied is the behavior of packets in a multi-hop system when a fixed transmission radius is specified and this radius is then optimized for throughput. A Markov chain model is also introduced and solved numerically to evaluate transmission and flow control strategies in these systems.

Automated Steering Control Design by Visual Feedback Approach —System Identification and Control Experiments with a Radio-Controlled Car—

NASA Astrophysics Data System (ADS)

Fujiwara, Yukihiro; Yoshii, Masakazu; Arai, Yasuhito; Adachi, Shuichi

Advanced safety vehicle(ASV)assists drivers’ manipulation to avoid trafic accidents. A variety of researches on automatic driving systems are necessary as an element of ASV. Among them, we focus on visual feedback approach in which the automatic driving system is realized by recognizing road trajectory using image information. The purpose of this paper is to examine the validity of this approach by experiments using a radio-controlled car. First, a practical image processing algorithm to recognize white lines on the road is proposed. Second, a model of the radio-controlled car is built by system identication experiments. Third, an automatic steering control system is designed based on H∞ control theory. Finally, the effectiveness of the designed control system is examined via traveling experiments.

SDR/STRS Flight Experiment and the Role of SDR-Based Communication and Navigation Systems

NASA Technical Reports Server (NTRS)

Reinhart, Richard C.

2008-01-01

This presentation describes an open architecture SDR (software defined radio) infrastructure, suitable for space-based radios and operations, entitled Space Telecommunications Radio System (STRS). SDR technologies will endow space and planetary exploration systems with dramatically increased capability, reduced power consumption, and less mass than conventional systems, at costs reduced by vigorous competition, hardware commonality, dense integration, minimizing the impact of parts obsolescence, improved interoperability, and software re-use. To advance the SDR architecture technology and demonstrate its applicability in space, NASA is developing a space experiment of multiple SDRs each with various waveforms to communicate with NASA s TDRSS satellite and ground networks, and the GPS constellation. An experiments program will investigate S-band and Ka-band communications, navigation, and networking technologies and operations.

Mapping the Ice Depth of Europa with Ultrahigh Energy Particles

NASA Astrophysics Data System (ADS)

Romero-Wolf, A.; Naudet, C. J.

2012-12-01

There has been recent interest in applying radio emission of ultra-high energy neutrinos interacting in the ice of Europa. The idea was first described by Gorham (2004)[1] in the context of ultra-high energy particle detection. Shoji, Kurita, and Tanaka (2011)[2] proposed a technique for measuring ice depth using the radio intensity distribution of radio impulses emitted by interactions deep in the Europan ice. Miller, Schaefer, and Sequeira (2012)[3] follow up this study with a simulation of a radio detector mission to constrain the ice depth of Europa. The radio signal results from an effect proposed by Askar'yan (1962)[4] where the particle shower induced by the neutrino interaction accumulates a charge excess traveling faster than the speed of light in the medium and produces a coherent Cherenkov pulse at radio frequencies. We evaluate the feasibility of such a mission given the current state of knowledge of ultra-high energy particle detection and radio pulse production. References [1] Gorham (2004), Planet-sized Detectors for Ultra-high Energy Neutrinos & Cosmic Rays, NASA Advanced Planning Office's Capability Roadmap Public Workshop, Nov. 30, 2004, astro-ph/0411510 [2] Shoji, Kurita, and Tanaka (2011), Constraint of Europan ice thickness by measuring electromagnetic emissions induced by neutrino interaction, Geophysical Research Letters, 38, L08202 [3] Miller, Shaefer, Sequeira, PRIDE (Passive Radio [frequency] Ice Depth Experiment): An instrument to passively measure ice depth from a Europan orbiter using neutrinos, Icarus 220 877-888 [4] Askar'yan (1962), Excess negative charge of an electron photon shower and its coherent radiation originating from it. Radio recording of showers under the ground and on the Moon, Sov. Phys. JETP, 14, 441-443.

Non-Maximally Decimated Filter Banks Enable Adaptive Frequency Hopping for Unmanned Aircraft Vehicles

NASA Technical Reports Server (NTRS)

Venosa, Elettra; Vermeire, Bert; Alakija, Cameron; Harris, Fred; Strobel, David; Sheehe, Charles J.; Krunz, Marwan

2017-01-01

In the last few years, radio technologies for unmanned aircraft vehicle (UAV) have advanced very rapidly. The increasing need to fly unmanned aircraft systems (UAS) in the national airspace system (NAS) to perform missions of vital importance to national security, defense, and science has pushed ahead the design and implementation of new radio platforms. However, a lot still has to be done to improve those radios in terms of performance and capabilities. In addition, an important aspect to account for is hardware cost and the feasibility to implement these radios using commercial off-the-shelf (COTS) components. UAV radios come with numerous technical challenges and their development involves contributions at different levels of the design. Cognitive algorithms need to be developed in order to perform agile communications using appropriate frequency allocation while maintaining safe and efficient operations in the NAS and, digital reconfigurable architectures have to be designed in order to ensure a prompt response to environmental changes. Command and control (C2) communications have to be preserved during "standard" operations while crew operations have to be minimized. It is clear that UAV radios have to be software-defined systems, where size, weight and power consumption (SWaP) are critical parameters. This paper provides preliminary results of the efforts performed to design a fully digital radio architecture as part of a NASA Phase I STTR. In this paper, we will explain the basic idea and technical principles behind our dynamic/adaptive frequency hopping radio for UAVs. We will present our Simulink model of the dynamic FH radio transmitter design for UAV communications and show simulation results and FPGA system analysis.

The Hessdalen Luminous Phenomenon: A Data Analysis

NASA Astrophysics Data System (ADS)

Teodorani, M.; Strand, E. P.

1998-08-01

In the period 21 January - 26 February 1984, a group of research engineers belonging to "Project Hessdalen", carried out instrumental investigations on a luminous atmospheric phenomenon occurring with strong recurrence in the area of Hessdalen in Norway. Several multi-mode instruments were used in order to monitor the phenomenon. In the present work, an analytical attempt, based on the data achieved during the 1984 investigation period, has been done in order to explain such a phenomenon. The following main results are presented: (1) the luminous phenomenon occurs with a periodicity of about one day and is approximately coincident with some peculiar magnetic pulsations and, more scarcely, with some components of radio emission; (2) magnetometric data, radar data and some components of radiometric data show some slight correlation with daily solar activity. Hypothesis regarding formation of solar-driven plasmoids acquiring self-governing EM and magnetic fields, is further ventured and discussed. Technical requirements for future instrumental research are presented as well.

Deep learning for hybrid EEG-fNIRS brain-computer interface: application to motor imagery classification.

PubMed

Chiarelli, Antonio Maria; Croce, Pierpaolo; Merla, Arcangelo; Zappasodi, Filippo

2018-06-01

Brain-computer interface (BCI) refers to procedures that link the central nervous system to a device. BCI was historically performed using electroencephalography (EEG). In the last years, encouraging results were obtained by combining EEG with other neuroimaging technologies, such as functional near infrared spectroscopy (fNIRS). A crucial step of BCI is brain state classification from recorded signal features. Deep artificial neural networks (DNNs) recently reached unprecedented complex classification outcomes. These performances were achieved through increased computational power, efficient learning algorithms, valuable activation functions, and restricted or back-fed neurons connections. By expecting significant overall BCI performances, we investigated the capabilities of combining EEG and fNIRS recordings with state-of-the-art deep learning procedures. We performed a guided left and right hand motor imagery task on 15 subjects with a fixed classification response time of 1 s and overall experiment length of 10 min. Left versus right classification accuracy of a DNN in the multi-modal recording modality was estimated and it was compared to standalone EEG and fNIRS and other classifiers. At a group level we obtained significant increase in performance when considering multi-modal recordings and DNN classifier with synergistic effect. BCI performances can be significantly improved by employing multi-modal recordings that provide electrical and hemodynamic brain activity information, in combination with advanced non-linear deep learning classification procedures.

Deep learning for hybrid EEG-fNIRS brain–computer interface: application to motor imagery classification

NASA Astrophysics Data System (ADS)

Chiarelli, Antonio Maria; Croce, Pierpaolo; Merla, Arcangelo; Zappasodi, Filippo

2018-06-01

Objective. Brain–computer interface (BCI) refers to procedures that link the central nervous system to a device. BCI was historically performed using electroencephalography (EEG). In the last years, encouraging results were obtained by combining EEG with other neuroimaging technologies, such as functional near infrared spectroscopy (fNIRS). A crucial step of BCI is brain state classification from recorded signal features. Deep artificial neural networks (DNNs) recently reached unprecedented complex classification outcomes. These performances were achieved through increased computational power, efficient learning algorithms, valuable activation functions, and restricted or back-fed neurons connections. By expecting significant overall BCI performances, we investigated the capabilities of combining EEG and fNIRS recordings with state-of-the-art deep learning procedures. Approach. We performed a guided left and right hand motor imagery task on 15 subjects with a fixed classification response time of 1 s and overall experiment length of 10 min. Left versus right classification accuracy of a DNN in the multi-modal recording modality was estimated and it was compared to standalone EEG and fNIRS and other classifiers. Main results. At a group level we obtained significant increase in performance when considering multi-modal recordings and DNN classifier with synergistic effect. Significance. BCI performances can be significantly improved by employing multi-modal recordings that provide electrical and hemodynamic brain activity information, in combination with advanced non-linear deep learning classification procedures.

A Digital Bistatic Radar Instrument for High-Latitude Ionospheric E-region Research

NASA Astrophysics Data System (ADS)

Huyghebaert, D. R.; Hussey, G. C.; McWilliams, K. A.; St-Maurice, J. P.

2015-12-01

A new 50 MHz ionospheric E-region radar is currently being developed and will be operational for the summer of 2016. The radar group in the Institute of Space and Atmospheric Studies (ISAS) at the University of Saskatchewan is designing and building the radar which will be located near the university in Saskatoon, SK, Canada and will have a field of view over Wollaston Lake in northern Saskatchewan. This novel radar will simultaneously obtain high spatial and temporal resolution through the use of a bistatic setup and pulse modulation techniques. The bistatic setup allows the radar to transmit and receive continuously, while pulse modulation techniques allow for enhanced spatial resolution, only constrained by the radio bandwidth licensing available. A ten antenna array will be used on both the transmitter and receiver sides, with each antenna having an independent radio path. This enables complete digital control of the transmitted 1 kW signal at each antenna, allowing for digital beam steering and multimode broadcasting. On the receiver side the raw digitized signal will be recorded from each antenna, allowing for complete digital post-processing to be performed on the data. From the measurements provided using these modern digital radar capabilities, further insights into the physics of E-region phenomena, such as Alfvén waves propagating from the magnetosphere above and ionospheric irregularities, may be investigated.

GLOBECOM '84 - Global Telecommunications Conference, Atlanta, GA, November 26-29, 1984, Conference Record. Volume 1

NASA Astrophysics Data System (ADS)

The subjects discussed are related to LSI/VLSI based subscriber transmission and customer access for the Integrated Services Digital Network (ISDN), special applications of fiber optics, ISDN and competitive telecommunication services, technical preparations for the Geostationary-Satellite Orbit Conference, high-capacity statistical switching fabrics, networking and distributed systems software, adaptive arrays and cancelers, synchronization and tracking, speech processing, advances in communication terminals, full-color videotex, and a performance analysis of protocols. Advances in data communications are considered along with transmission network plans and progress, direct broadcast satellite systems, packet radio system aspects, radio-new and developing technologies and applications, the management of software quality, and Open Systems Interconnection (OSI) aspects of telematic services. Attention is given to personal computers and OSI, the role of software reliability measurement in information systems, and an active array antenna for the next-generation direct broadcast satellite.

Coming cockpit avionics

NASA Technical Reports Server (NTRS)

Mciver, D.; Hatfield, J. J.

1978-01-01

Digital and display technology combined with human factors research under development today are expected to become operational in the commercial aircraft of the 1990s. Attention is given to reducing the pilot's workload and increasing aircraft reliability through integration of electronic systems, and through multi-mode displays. Recent advances in display technology are outlined, including electroluminescent panels, beam penetration color CRTs, liquid crystal modules, and LED panels and indicators. Research cockpits are described in terms of simplification of aircraft systems evaluation and control.

A Multimodality Ultramicrospectroscope (MUMS): Nanoscale Imaging with Integrated Spectroscopies for Chemical and Biomolecular Identification

DTIC Science & Technology

2010-11-10

nanoparticles, and nanoshells by making sub 100 nm diameter nanoshells to mesoscopic sized nanoparticles (gold meatballs ) and micron sized nanoshells. In...mesoscopic gold ‘ meatballs ’, gold bipyrimids etc. In addition nanoparticles such as the nanostar demonstrate some of the highest LSPR sensitivity but...20, 535-538 (2008). 64. H. Wang and N. J. Halas, “Mesoscopic Au ‘ Meatball ’ Particles”, Advanced Materials 20, 820-825 (2008). 65. S. Priya

Advances in organ preserving strategies in rectal cancer patients.

PubMed

Stijns, Rutger C H; Tromp, Mike-Stephen R; Hugen, Niek; de Wilt, Johannes H W

2018-02-01

Treatment of rectal cancer patients has been subjected to change over the past thirty years. Total mesorectal excision is considered the cornerstone of rectal cancer treatment, but is also associated with significant morbidity resulting in an impaired quality of life. The addition of neoadjuvant chemoradiotherapy to surgery has shown to improve survival and local control and may lead to a partial or even complete response (CR). This raises questions regarding the necessity for subsequent radical surgery. After careful patient selection local excision and wait-and-see approaches are explored, aiming to improve quality of life without compromising oncological outcome. A multimodality diagnostic approach for optimal staging is crucial in determining the appropriate neoadjuvant treatment regimen. Adequate endoscopic restaging of rectal tumours after multimodality treatment will aid in selecting patients who are eligible for an organ preserving approach. The role and accuracy of imaging in the detection of the primary tumour, residual rectal cancer or local recurrence seems vital. Alternative neoadjuvant regimens are currently explored to increase the rate of clinical CRs, which may support organ preserving approaches. This review aims to generate insight into the advances in diagnostics and treatment modalities in all stages of rectal cancer and will highlight future studies that may support further implementation of organ preservation treatment in rectal cancer. Copyright © 2017 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

The role of multimodal treatment in patients with advanced lung neuroendocrine tumors

PubMed Central

Ungaro, Antonio; Spada, Francesca; Cella, Chiara Alessandra; Pisa, Eleonora; Barberis, Massimo; Grana, Chiara; Zerini, Dario; Bertani, Emilio; Ribero, Dario; Funicelli, Luigi; Bonomo, Guido; Ravizza, Davide; Guarize, Juliana; De Marinis, Filippo; Petrella, Francesco; Del Signore, Ester; Pelosi, Giuseppe; Spaggiari, Lorenzo

2017-01-01

Lung neuroendocrine tumors (NETs) comprise typical (TC) and atypical carcinoids (AC). They represent the well differentiated (WD) or low/intermediate grade forms of lung neuroendocrine neoplasms (NENs). Unlike the lung poorly differentiated NENs, that are usually treated with chemotherapy, lung NETs can be managed with several different therapies, making a multidisciplinary interaction a key point. We critically discussed the multimodal clinical management of patients with advanced lung NETs. Provided that no therapeutic algorithm has been validate so far, each clinical case should be discussed within a NEN-dedicated multidisciplinary team. Among the systemic therapies available for metastatic lung NETs everolimus is the only approved drug, on the basis of the results of the phase III RADIANT-4 trial. Another phase III trial, the SPINET, is ongoing comparing lanreotide with placebo. Peptide receptor radionuclide therapy and chemotherapy were not studied within phase III trials for lung NETs, and they have been reported to be active within retrospective or phase II prospective studies. Temozolomide and oxaliplatin are two interesting chemotherapeutic agents in lung NETs. While some European Institutions were certificated as Centers of Excellence for gastroenteropancreatic NENs by the European Neuroendocrine Tumor Society (ENETS), an equivalent ENETS certification for lung NENs does not exist yet. Ideally a lung NEN-dedicated multidisciplinary tumor board should include NEN-dedicated medical oncologists, thoracic medical oncologist, thoracic surgeons, pathologists, interventional radiologists, endocrinologists, radiotherapists, interventional pneumologists, nuclear physician. PMID:29201453

Telemetry Tests Of The Advanced Receiver II

NASA Technical Reports Server (NTRS)

Hinedi, Sami M.; Bevan, Roland P.; Marina, Miguel

1993-01-01

Report describes telemetry tests of Advanced Receiver II (ARX-II): digital radio receiving subsystem operating on intermediate-frequency output of another receiving subsystem called "multimission receiver" (MMR), detecting carrier, subcarrier, and data-symbol signals transmitted by spacecraft, and extracts Doppler information from signals. Analysis of data shows performance of MMR/ARX-II system comparable and sometimes superior to performances of Blk-III/BPA and Blk-III/SDA/SSA systems.

"We Didn't Even Realize that Kids like Us Could Go on the Radio"--An Evaluation of a Victorian Schools Youth Development Programme

ERIC Educational Resources Information Center

Broadbent, Robyn S.; Papadopoulos, Theo

2010-01-01

This paper reports on a comprehensive evaluation of the Advance programme by Victoria University in 2007/08. Advance is a flexible school-based programme for young people to volunteer or implement a project of benefit to their communities in the state of Victoria, in Australia. It is a partnership between the Office for Youth, Victorian government…

The Evolution of Instrument Flying in the U.S. Army.

DTIC Science & Technology

1988-04-01

had learned to fly in World War One without instruments. They either distrusted instruments and avoided clouds, or were "seat-of- the-pants" flyers...hooded flight training, Basic students received six hours, and Advanced students received fifteen. Primary and Basic students learned aircraft control and...instrument maneuvers while Advanced students learned radio-navigation.;’ The twenty-seven hours of instrument 23 flying represented 11 percent of the

Aerobot Autonomy Architecture

NASA Technical Reports Server (NTRS)

Elfes, Alberto; Hall, Jeffery L.; Kulczycki, Eric A.; Cameron, Jonathan M.; Morfopoulos, Arin C.; Clouse, Daniel S.; Montgomery, James F.; Ansar, Adnan I.; Machuzak, Richard J.

2009-01-01

An architecture for autonomous operation of an aerobot (i.e., a robotic blimp) to be used in scientific exploration of planets and moons in the Solar system with an atmosphere (such as Titan and Venus) is undergoing development. This architecture is also applicable to autonomous airships that could be flown in the terrestrial atmosphere for scientific exploration, military reconnaissance and surveillance, and as radio-communication relay stations in disaster areas. The architecture was conceived to satisfy requirements to perform the following functions: a) Vehicle safing, that is, ensuring the integrity of the aerobot during its entire mission, including during extended communication blackouts. b) Accurate and robust autonomous flight control during operation in diverse modes, including launch, deployment of scientific instruments, long traverses, hovering or station-keeping, and maneuvers for touch-and-go surface sampling. c) Mapping and self-localization in the absence of a global positioning system. d) Advanced recognition of hazards and targets in conjunction with tracking of, and visual servoing toward, targets, all to enable the aerobot to detect and avoid atmospheric and topographic hazards and to identify, home in on, and hover over predefined terrain features or other targets of scientific interest. The architecture is an integrated combination of systems for accurate and robust vehicle and flight trajectory control; estimation of the state of the aerobot; perception-based detection and avoidance of hazards; monitoring of the integrity and functionality ("health") of the aerobot; reflexive safing actions; multi-modal localization and mapping; autonomous planning and execution of scientific observations; and long-range planning and monitoring of the mission of the aerobot. The prototype JPL aerobot (see figure) has been tested extensively in various areas in the California Mojave desert.

Progress on the Low Frequency All Sky Monitor

NASA Astrophysics Data System (ADS)

Ford, Anthony; Jenet, F.; Craig, J.; Creighton, T. D.; Dartez, L. P.; Hicks, B.; Hinojosa, J.; Jaramillo, R.; Kassim, N. E.; Lunsford, G.; Miller, R. B.; Murray, J.; Ray, P. S.; Rivera, J.; Taylor, G. B.

2013-01-01

The Low Frequency All Sky Monitor is a system of geographically separated radio arrays dedicated to the study of radio transients. LoFASM consists of four stations, each comprised of 12 cross-dipole antennas designed to operate between 5-88MHz. The antennas and front end electronics for LoFASM were designed by the Naval Research Laboratory for the Long Wavelength Array project. Over the last year, undergraduate students from the University of Texas at Brownsville’s Center for Advanced Radio Astronomy have been establishing these stations around the continental US, consisting of sites located in Port Mansfield, Texas, the LWA North Arm site of the LWA1 Radio Observatory in New Mexico, adjacent to the North Arm of the Very Large Array, the Green Bank Radio Observatory, West Virginia, and NASA’s Goldstone tracking complex in California. In combination with the establishment of these sites was the development of the analog hardware, which consists of commercial off-the-shelf RF splitter/combiners and a custom amplifier and filter chain designed by colleagues at the University of New Mexico. This poster will expound on progress in site installation and development of the analog signal chain.

The South Pole, Antarctica, Solar Radio Telescope (SPASRT) System

NASA Astrophysics Data System (ADS)

Gerrard, A. J.; Weatherwax, A. T.; Gary, D. E.; Kujawski, J. T.; Nita, G. M.; Melville, R.; Stillinger, A.; Jeffer, G.

2014-12-01

The study of the sun in the radio portion of the electromagnetic spectrum furthers our understanding of fundamental solar processes observed in the X-ray, UV, and visible regions of the spectrum. For example, the study of solar radio bursts, which have been shown to cause serious disruptions of technologies at Earth, are essential for advancing our knowledge and understanding of solar flares and their relationship to coronal mass ejections and solar energetic particles, as well as the underlying particle acceleration mechanisms associated with these processes. In addition, radio coverage of the solar atmosphere could yield completely new insights into the variations of output solar energy, including Alfven wave propagation through the solar atmosphere and into the solar wind, which can potentially modulate and disturb the solar wind and Earth's geospace environment. In this presentation we discuss the development, construction, and testing of the South Pole, Antarctica, Solar Radio Telescope that is planned for installation at South Pole. The system will allow for 24-hour continuous, long-term observations of the sun across the 1-18 GHz frequency band and allow for truly continuous solar observations. We show that this system will enable unique scientific investigations of the solar atmosphere.

Three-dimensional holographic optical manipulation through a high-numerical-aperture soft-glass multimode fibre

NASA Astrophysics Data System (ADS)

Leite, Ivo T.; Turtaev, Sergey; Jiang, Xin; Šiler, Martin; Cuschieri, Alfred; Russell, Philip St. J.; Čižmár, Tomáš

2018-01-01

Holographic optical tweezers (HOT) hold great promise for many applications in biophotonics, allowing the creation and measurement of minuscule forces on biomolecules, molecular motors and cells. Geometries used in HOT currently rely on bulk optics, and their exploitation in vivo is compromised by the optically turbid nature of tissues. We present an alternative HOT approach in which multiple three-dimensional (3D) traps are introduced through a high-numerical-aperture multimode optical fibre, thus enabling an equally versatile means of manipulation through channels having cross-section comparable to the size of a single cell. Our work demonstrates real-time manipulation of 3D arrangements of micro-objects, as well as manipulation inside otherwise inaccessible cavities. We show that the traps can be formed over fibre lengths exceeding 100 mm and positioned with nanometric resolution. The results provide the basis for holographic manipulation and other high-numerical-aperture techniques, including advanced microscopy, through single-core-fibre endoscopes deep inside living tissues and other complex environments.

Unobtrusive Behavioral and Activity-Related Multimodal Biometrics: The ACTIBIO Authentication Concept

PubMed Central

Drosou, A.; Ioannidis, D.; Moustakas, K.; Tzovaras, D.

2011-01-01

Unobtrusive Authentication Using ACTIvity-Related and Soft BIOmetrics (ACTIBIO) is an EU Specific Targeted Research Project (STREP) where new types of biometrics are combined with state-of-the-art unobtrusive technologies in order to enhance security in a wide spectrum of applications. The project aims to develop a modular, robust, multimodal biometrics security authentication and monitoring system, which uses a biodynamic physiological profile, unique for each individual, and advancements of the state of the art in unobtrusive behavioral and other biometrics, such as face, gait recognition, and seat-based anthropometrics. Several shortcomings of existing biometric recognition systems are addressed within this project, which have helped in improving existing sensors, in developing new algorithms, and in designing applications, towards creating new, unobtrusive, biometric authentication procedures in security-sensitive, Ambient Intelligence environments. This paper presents the concept of the ACTIBIO project and describes its unobtrusive authentication demonstrator in a real scenario by focusing on the vision-based biometric recognition modalities. PMID:21380485

Multimode bolometer development for the PIXIE instrument

NASA Astrophysics Data System (ADS)

Nagler, Peter C.; Crowley, Kevin T.; Denis, Kevin L.; Devasia, Archana M.; Fixsen, Dale J.; Kogut, Alan J.; Manos, George; Porter, Scott; Stevenson, Thomas R.

2016-07-01

The Primordial Inflation Explorer (PIXIE) is an Explorer-class mission concept designed to measure the polar- ization and absolute intensity of the cosmic microwave background. In the following, we report on the design, fabrication, and performance of the multimode polarization-sensitive bolometers for PIXIE, which are based on silicon thermistors. In particular we focus on several recent advances in the detector design, including the implementation of a scheme to greatly raise the frequencies of the internal vibrational modes of the large-area, low-mass optical absorber structure consisting of a grid of micromachined, ion-implanted silicon wires. With ˜ 30 times the absorbing area of the spider-web bolometers used by Planck, the tensioning scheme enables the PIXIE bolometers to be robust in the vibrational and acoustic environment at launch of the space mission. More generally, it could be used to reduce microphonic sensitivity in other types of low temperature detectors. We also report on the performance of the PIXIE bolometers in a dark cryogenic environment.

Demonstration of glass-based photonic interposer for mid-board-optical engines and electrical-optical circuit board (EOCB) integration strategy

NASA Astrophysics Data System (ADS)

Schröder, H.; Neitz, M.; Schneider-Ramelow, M.

2018-02-01

Due to its optical transparency and superior dielectric properties glass is regarded as a promising candidate for advanced applications as active photonic interposer for mid-board-optics and optical PCB waveguide integration. The concepts for multi-mode and single-mode photonic system integration are discussed and related demonstration project results will be presented. A hybrid integrated photonic glass body interposer with integrated optical lenses for multi-mode data communication wavelength of 850 nm have been realized. The paper summarizes process developments which allow cost efficient metallization of TGV. Electro-optical elements like photodiodes and VCSELs can be directly flip-chip mounted on the glass substrate according to the desired lens positions. Furthermore results for a silicon photonic based single-mode active interposer integration onto a single mode glass made EOCB will be compared in terms of packaging challenges. The board level integration strategy for both of these technological approaches and general next generation board level integration concepts for photonic interposer will be introductorily discussed.

Unobtrusive behavioral and activity-related multimodal biometrics: The ACTIBIO Authentication concept.

PubMed

Drosou, A; Ioannidis, D; Moustakas, K; Tzovaras, D

2011-03-01

Unobtrusive Authentication Using ACTIvity-Related and Soft BIOmetrics (ACTIBIO) is an EU Specific Targeted Research Project (STREP) where new types of biometrics are combined with state-of-the-art unobtrusive technologies in order to enhance security in a wide spectrum of applications. The project aims to develop a modular, robust, multimodal biometrics security authentication and monitoring system, which uses a biodynamic physiological profile, unique for each individual, and advancements of the state of the art in unobtrusive behavioral and other biometrics, such as face, gait recognition, and seat-based anthropometrics. Several shortcomings of existing biometric recognition systems are addressed within this project, which have helped in improving existing sensors, in developing new algorithms, and in designing applications, towards creating new, unobtrusive, biometric authentication procedures in security-sensitive, Ambient Intelligence environments. This paper presents the concept of the ACTIBIO project and describes its unobtrusive authentication demonstrator in a real scenario by focusing on the vision-based biometric recognition modalities.

Use of multidimensional, multimodal imaging and PACS to support neurological diagnoses

NASA Astrophysics Data System (ADS)

Wong, Stephen T. C.; Knowlton, Robert C.; Hoo, Kent S.; Huang, H. K.

1995-05-01

Technological advances in brain imaging have revolutionized diagnosis in neurology and neurological surgery. Major imaging techniques include magnetic resonance imaging (MRI) to visualize structural anatomy, positron emission tomography (PET) to image metabolic function and cerebral blood flow, magnetoencephalography (MEG) to visualize the location of physiologic current sources, and magnetic resonance spectroscopy (MRS) to measure specific biochemicals. Each of these techniques studies different biomedical aspects of the brain, but there lacks an effective means to quantify and correlate the disparate imaging datasets in order to improve clinical decision making processes. This paper describes several techniques developed in a UNIX-based neurodiagnostic workstation to aid the noninvasive presurgical evaluation of epilepsy patients. These techniques include online access to the picture archiving and communication systems (PACS) multimedia archive, coregistration of multimodality image datasets, and correlation and quantitation of structural and functional information contained in the registered images. For illustration, we describe the use of these techniques in a patient case of nonlesional neocortical epilepsy. We also present out future work based on preliminary studies.

Planar polymer and glass graded index waveguides for data center applications

NASA Astrophysics Data System (ADS)

Pitwon, Richard; Yamauchi, Akira; Brusberg, Lars; Wang, Kai; Ishigure, Takaaki; Schröder, Henning; Neitz, Marcel; Worrall, Alex

2016-03-01

Embedded optical waveguide technology for optical printed circuit boards (OPCBs) has advanced considerably over the past decade both in terms of materials and achievable waveguide structures. Two distinct classes of planar graded index multimode waveguide have recently emerged based on polymer and glass materials. We report on the suitability of graded index polymer waveguides, fabricated using the Mosquito method, and graded index glass waveguides, fabricated using ion diffusion on thin glass foils, for deployment within future data center environments as part of an optically disaggregated architecture. To this end, we first characterize the wavelength dependent performance of different waveguide types to assess their suitability with respect to two dominant emerging multimode transceiver classes based on directly modulated 850 nm VCSELs and 1310 silicon photonics devices. Furthermore we connect the different waveguide types into an optically disaggregated data storage system and characterize their performance with respect to different common high speed data protocols used at the intra and inter rack level including 10 Gb Ethernet and Serial Attached SCSI.

From ancient to avant-garde: a review of traditional and modern multimodal approaches to surgical anatomy education.

PubMed

Hu, Minhao; Wattchow, David; de Fontgalland, Dayan

2018-03-01

The landscape of surgical anatomy education is progressively changing. Traditional methods, such as cadaveric dissection and didacticism are being increasingly phased out in undergraduate courses for multimodal approaches incorporating problem-based learning, radiology and computer-based simulations. Although effective at clinically contextualizing and integrating anatomical information, these approaches may be a poor substitute for fostering a grasp of foundational 'pure' anatomy. Dissection is ideal for this purpose and hence remains the cornerstone of anatomical education. However, novel methods and technological advancements continually give way to adjuncts such as cadaveric surgery, three-dimensional printing, virtual simulation and live surgical streaming, which have demonstrated significant efficacy alone or alongside dissection. Therefore, although divergent paradigms of 'new versus old' approaches have engulfed and divided the community, educators should seek to integrate the ancient and avant-garde to comprehensively satisfy all of the modern anatomy learner's educational needs. © 2017 Royal Australasian College of Surgeons.

Multimode Bolometer Development for the PIXIE Instrument

NASA Technical Reports Server (NTRS)

Nagler, Peter C.; Crowley, Kevin T.; Denis, Kevin L.; Devasia, Archana M.; Fixsen, Dale J.; Kogut, Alan J.; Manos, George; Porter, Scott; Stevenson, Thomas R.

2016-01-01

The Primordial Inflation Explorer (PIXIE) is an Explorer-class mission concept designed to measure the polarization and absolute intensity of the cosmic microwave background. In the following, we report on the design, fabrication, and performance of the multimode polarization-sensitive bolometers for PIXIE, which are based on silicon thermistors. In particular we focus on several recent advances in the detector design, including the implementation of a scheme to greatly raise the frequencies of the internal vibrational modes of the large-area, low-mass optical absorber structure consisting of a grid of micromachined, ion-implanted silicon wires. With approximately 30 times the absorbing area of the spider-web bolometers used by Planck, the tensioning scheme enables the PIXIE bolometers to be robust in the vibrational and acoustic environment at launch of the space mission. More generally, it could be used to reduce microphonic sensitivity in other types of low temperature detectors. We also report on the performance of the PIXIE bolometers in a dark cryogenic environment.

Multimode Bolometer Development for the Primordial Inflation Explorer (PIXIE) Instrument

NASA Technical Reports Server (NTRS)

Nagler, Peter C.; Crowley, Kevin T.; Denis, Kevin L.; Devasia, Archana M.; Fixsen, Dale J.; Kogut, Alan J.; Manos, George; Porter, Scott; Stevenson, Thomas R.

2016-01-01

The Primordial Inflation Explorer (PIXIE) is an Explorer-class mission concept designed to measure the polarization and absolute intensity of the cosmic microwave background [1]. In this work, we report on the design, fabrication, and performance of the multimode polarization-sensitive bolometers for PIXIE, which are based on silicon thermistors. In particular we focus on several recent advances in the detector design, including the implementation of a tensioning scheme to greatly raise the frequencies of the internal vibrational modes of the large-area, low-mass optical absorber structure consisting of a grid of micromachined, ion-implanted silicon wires. With 30 times the absorbing area of the spider-web bolometers used by Planck, the tensioning scheme enables the PIXIE bolometers to be robust in the vibrational and acoustic environment at launch of the space mission. More generally, it could be used to reduce microphonic sensitivity in other types of low temperature detectors. We also report on the performance of the PIXIE bolometers in a dark cryogenic environment.

Effectiveness of radio waves application in modern general dental procedures: An update.

PubMed

Qureshi, Arslan; Kellesarian, Sergio Varela; Pikos, Michael A; Javed, Fawad; Romanos, Georgios E

2017-01-01

The purpose of the present study was to review indexed literature and provide an update on the effectiveness of high-frequency radio waves (HRW) application in modern general dentistry procedures. Indexed databases were searched to identify articles that assessed the efficacy of radio waves in dental procedures. Radiosurgery is a refined form of electrosurgery that uses waves of electrons at a radiofrequency ranging between 2 and 4 MHz. Radio waves have also been reported to cause much less thermal damage to peripheral tissues compared with electrosurgery or carbon dioxide laser-assisted surgery. Formation of reparative dentin in direct pulp capping procedures is also significantly higher when HRW are used to achieve hemostasis in teeth with minimally exposed dental pulps compared with traditional techniques for achieving hemostasis. A few case reports have reported that radiosurgery is useful for procedures such as gingivectomy and gingivoplasty, stage-two surgery for implant exposure, operculectomy, oral biopsy, and frenectomy. Radiosurgery is a relatively modern therapeutic methodology for the treatment of trigeminal neuralgia; however, its long-term efficacy is unclear. Radio waves can also be used for periodontal procedures, such as gingivectomies, coronal flap advancement, harvesting palatal grafts for periodontal soft tissue grafting, and crown lengthening. Although there are a limited number of studies in indexed literature regarding the efficacy of radio waves in modern dentistry, the available evidence shows that use of radio waves is a modernization in clinical dentistry that might be a contemporary substitute for traditional clinical dental procedures.

Radio Galaxy Zoo: cosmological alignment of radio sources

NASA Astrophysics Data System (ADS)

Contigiani, O.; de Gasperin, F.; Miley, G. K.; Rudnick, L.; Andernach, H.; Banfield, J. K.; Kapińska, A. D.; Shabala, S. S.; Wong, O. I.

2017-11-01

We study the mutual alignment of radio sources within two surveys, Faint Images of the Radio Sky at Twenty-centimetres (FIRST) and TIFR GMRT Sky Survey (TGSS). This is done by producing two position angle catalogues containing the preferential directions of respectively 30 059 and 11 674 extended sources distributed over more than 7000 and 17 000 deg2. The identification of the sources in the FIRST sample was performed in advance by volunteers of the Radio Galaxy Zoo (RGZ) project, while for the TGSS sample it is the result of an automated process presented here. After taking into account systematic effects, marginal evidence of a local alignment on scales smaller than 2.5 deg is found in the FIRST sample. The probability of this happening by chance is found to be less than 2 per cent. Further study suggests that on scales up to 1.5 deg the alignment is maximal. For one third of the sources, the RGZ volunteers identified an optical counterpart. Assuming a flat Λ cold dark matter cosmology with Ω _m = 0.31, Ω _Λ = 0.69, we convert the maximum angular scale on which alignment is seen into a physical scale in the range [19, 38] Mpc h_{70}^{-1}. This result supports recent evidence reported by Taylor and Jagannathan of radio jet alignment in the 1.4 deg2 ELAIS N1 field observed with the Giant Metrewave Radio Telescope. The TGSS sample is found to be too sparsely populated to manifest a similar signal.

Use of brachial plexus blockade and medetomidine-ketamine-isoflurane anaesthesia for repair of radio-ulna fracture in an adult cheetah (Acinonyx jubatus).

PubMed

Kimeli, Peter; Mogoa, Eddy M; Mwangi, Willy E; Kipyegon, Ambrose N; Kirui, Gilbert; Muasya, Daniel W; Mande, John D; Kariuki, Edward; Mijele, Dominic

2014-10-10

Regional anaesthetic techniques have been used in combination with systemic analgesics during small animal surgery to provide multimodal analgesia. Brachial plexus nerves block using local anaesthetics provides analgesia of the thoracic limb through desensitization of the nerves that provide sensory and motor innervation. This has been shown to reduce intra-operative anesthetic requirements and provide postoperative pain relief. Decreasing the doses of general anaesthetics allows more stable cardiopulmonary function during anaesthesia and the development of less side effects. The present case reports a successful use of brachial plexus blockade to supplement medetomidine-ketamine-isoflurane anaesthesia for repair of radio-ulna fracture in an adult cheetah (acinonyx jubatus). An adult male Cheetah weighing about 65 kg was presented with a history of leg carrying lameness of the left forelimb sustained following a car accident a week earlier. Clinical examination under general anaesthesia revealed slight dehydration and a swelling with a wound on the caudo-medial aspect of the left radio-ulna region. Crepitation was present on manipulation and radiography confirmed a complete transverse radio-ulna fracture of the left forelimb, which required open reduction and internal fixation. Brachial plexus blockade using lignocaine hydrochloride was used to supplement medetomidine-ketamine-isoflurane anaesthesia for the surgical procedure. Isoflurane anaesthesia was maintained at 0.5 - 2.0% throughout the surgical procedure, which was uneventful. Temperature and cardio-pulmonary parameters remained stable intra-operatively. Limb paralysis extended for 5 hours post-operatively, suggesting prolonged anaesthesia. To the researchers' knowledge, this is the first reported case of the use of brachial plexus blockade to supplement general anaesthesia to facilitate forelimb surgery in an adult cheetah. The use of brachial plexus block with a light plane of general anaesthesia proved to be successful. Brachial plexus block had a sparing effect on isoflurane anaesthesia as evidenced by the concentration used for maintenance of anaesthesia and the stability of the cardiopulmonary function. Moreover, absence of autonomic cardiopulmonary reactions to the surgical manipulation may be attributed to the efficacy of brachial plexus block. This anaesthesia protocol is therefore recommended for surgeries of the forelimb in wild cats.

Molecular basis of 'hypoxic' breast cancer cell radio-sensitization: phytochemicals converge on radiation induced Rel signaling.

PubMed

Aravindan, Sheeja; Natarajan, Mohan; Herman, Terence S; Awasthi, Vibhudutta; Aravindan, Natarajan

2013-03-04

Heterogeneously distributed hypoxic areas are a characteristic property of locally advanced breast cancers (BCa) and generally associated with therapeutic resistance, metastases, and poor patient survival. About 50% of locally advanced BCa, where radiotherapy is less effective are suggested to be due to hypoxic regions. In this study, we investigated the potential of bioactive phytochemicals in radio-sensitizing hypoxic BCa cells. Hypoxic (O2-2.5%; N2-92.5%; CO2-5%) MCF-7 cells were exposed to 4 Gy radiation (IR) alone or after pretreatment with Curcumin (CUR), curcumin analog EF24, neem leaf extract (NLE), Genistein (GEN), Resveratrol (RES) or raspberry extract (RSE). The cells were examined for inhibition of NFκB activity, transcriptional modulation of 88 NFκB signaling pathway genes, activation and cellular localization of radio-responsive NFκB related mediators, eNos, Erk1/2, SOD2, Akt1/2/3, p50, p65, pIκBα, TNFα, Birc-1, -2, -5 and associated induction of cell death. EMSA revealed that cells exposed to phytochemicals showed complete suppression of IR-induced NFκB. Relatively, cells exposed EF24 revealed a robust inhibition of IR-induced NFκB. QPCR profiling showed induced expression of 53 NFκB signaling pathway genes after IR. Conversely, 53, 50, 53, 53, 53 and 53 of IR-induced genes were inhibited with EF24, NLE, CUR, GEN, RES and RSE respectively. In addition, 25, 29, 24, 16, 11 and 21 of 35 IR-suppressed genes were further inhibited with EF24, NLE, CUR, GEN, RES and RSE respectively. Immunoblotting revealed a significant attenuating effect of IR-modulated radio-responsive eNos, Erk1/2, SOD2, Akt1/2/3, p50, p65, pIκBα, TNFα, Birc-1, -2 and -5 with EF24, NLE, CUR, GEN, RES or RSE. Annexin V-FITC staining showed a consistent and significant induction of IR-induced cell death with these phytochemicals. Notably, EF24 robustly conferred IR-induced cell death. Together, these data identifies the potential hypoxic cell radio-sensitizers and further implies that the induced radio-sensitization may be exerted by selectively targeting IR-induced NFκB signaling.

Advanced Parkinson's or "complex phase" Parkinson's disease? Re-evaluation is needed.

PubMed

Titova, Nataliya; Martinez-Martin, Pablo; Katunina, Elena; Chaudhuri, K Ray

2017-12-01

Holistic management of Parkinson's disease, now recognised as a combined motor and nonmotor disorder, remains a key unmet need. Such management needs relatively accurate definition of the various stages of Parkinson's from early untreated to late palliative as each stage calls for personalised therapies. Management also needs to have a robust knowledge of the progression pattern and clinical heterogeneity of the presentation of Parkinson's which may manifest in a motor dominant or nonmotor dominant manner. The "advanced" stages of Parkinson's disease qualify for advanced treatments such as with continuous infusion or stereotactic surgery yet the concept of "advanced Parkinson's disease" (APD) remains controversial in spite of growing knowledge of the natural history of the motor syndrome of PD. Advanced PD is currently largely defined on the basis of consensus opinion and thus with several caveats. Nonmotor aspects of PD may also reflect advancing course of the disorder, so far not reflected in usual scale based assessments which are largely focussed on motor symptoms. In this paper, we discuss the problems with current definitions of "advanced" PD and also propose the term "complex phase" Parkinson's disease as an alternative which takes into account a multimodal symptoms and biomarker based approach in addition to patient preference.

Multimodal endocavitary ultrasound versus MRI and clinical findings in pre- and post-treatment advanced cervical cancer. Preliminary report.

PubMed

Csutak, Csaba; Badea, Radu; Bolboaca, Sorana D; Ordeanu, Claudia; Nagy, Viorica M; Fekete, Zsolt; Chiorean, Liliana; Dudea, Sorin M

2016-03-01

The aim of this study was to evaluate the use of pre and post-therapy transrectal and transvaginal ultrasonography (TRUS, TVUS) with contrast enhancement and strain elastography compared with clinical examination and magnetic resonance imaging (MRI) in the assessment of advanced stage cervical cancer. This was a prospective study, carried out over a period of nine months on subjects with advanced-stage cervical cancer (stage >/= IIB). All included patients were examined clinically and underwent abdomino-pelvic contrast enhanced MRI and multimodal US examinations (TRUS with strain elastography and contrast enhanced TVUS) at the time of diagnosis and after radiochemotherapy. Tumor size and staging at TRUS and TVUS was compared with the same data obtained by clinical examination and MRI. Pathology was the golden standard. Eight patients accomplished the inclusion criteria. In five cases the tumor stage was identical on clinical and MRI examinations. In all cases parametrial infiltration was diagnosed by all pre-treatment examinations. No significant differences were observed in tumor size between clinical, US and MRI exams either at baseline or post-therapy, in native or post-contrast examinations. The size of the tumor evaluated pre-treatment proved to be significantly smaller post-contrast in both US and MRI examinations compared with the native images. Post-therapy, no significant differences were observed on US measured tumor dimensions when comparing native with post-contrast images. Oppositely, significant smaller dimensions were observed on post-contrast MRI compared with native scans. TRUS is accurate in the estimation of pre-therapy cervical cancer dimension. The post therapy tumor evaluation is better performed with MRI. The use of intravenous contrast agents on both examinations did not improved the accuracy of tumor evaluation pre or post-therapy.

Communicating with the public using ATIS during disasters : a guide for practitioners.

DOT National Transportation Integrated Search

2007-04-01

Advanced Traveler Information Systems, ATIS, can play an important role in communicating essential information to the public : during disasters. Variable message signs, 511 telephone systems, highway advisory radio, and websites are some of the disse...

Quantum Theory of Hyperfine Structure Transitions in Diatomic Molecules.

ERIC Educational Resources Information Center

Klempt, E.; And Others

1979-01-01

Described is an advanced undergraduate laboratory experiment in which radio-frequency transitions between molecular hyperfine structure states may be observed. Aspects of the quantum theory applied to the analysis of this physical system, are discussed. (Authors/BT)

Programmable Ultra Lightweight System Adaptable Radio (PULSAR) Low Cost Telemetry - Access from Space Advanced Technologies or Down the Middle

NASA Technical Reports Server (NTRS)

Sims. Herb; Varnavas, Kosta; Eberly, Eric

2013-01-01

Software Defined Radio (SDR) technology has been proven in the commercial sector since the early 1990's. Today's rapid advancement in mobile telephone reliability and power management capabilities exemplifies the effectiveness of the SDR technology for the modern communications market. In contrast, presently qualified satellite transponder applications were developed during the early 1960's space program. Programmable Ultra Lightweight System Adaptable Radio (PULSAR, NASA-MSFC SDR) technology revolutionizes satellite transponder technology by increasing data through-put capability by, at least, an order of magnitude. PULSAR leverages existing Marshall Space Flight Center SDR designs and commercially enhanced capabilities to provide a path to a radiation tolerant SDR transponder. These innovations will (1) reduce the cost of NASA Low Earth Orbit (LEO) and Deep Space transponders, (2) decrease power requirements, and (3) a commensurate volume reduction. Also, PULSAR increases flexibility to implement multiple transponder types by utilizing the same hardware with altered logic - no analog hardware change is required - all of which can be accomplished in orbit. This provides high capability, low cost, transponders to programs of all sizes. The final project outcome would be the introduction of a Technology Readiness Level (TRL) 7 low-cost CubeSat to SmallSat telemetry system into the NASA Portfolio.

Radiolabeled Peptide Scaffolds for PET/SPECT - Optical in Vivo Imaging of Carbohydrate-Lectin Interactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deutscher, Susan

2014-09-30

The objective of this research is to develop phage display-selected peptides into radio- and fluoresecently- labeled scaffolds for the multimodal imaging of carbohydrate-lectin interactions. While numerous protein and receptor systems are being explored for the development of targeted imaging agents, the targeting and analysis of carbohydrate-lectin complexes in vivo remains relatively unexplored. Antibodies, nanoparticles, and peptides are being developed that target carbohydrate-lectin complexes in living systems. However, antibodies and nanoparticles often suffer from slow clearance and toxicity problems. Peptides are attractive alternative vehicles for the specific delivery of radionuclides or fluorophores to sites of interest in vivo, although, because ofmore » their size, uptake and retention may be less than antibodies. We have selected high affinity peptides that bind a specific carbohydrate-lectin complex involved in cell-cell adhesion and cross-linking using bacteriophage (phage) display technologies (1,2). These peptides have allowed us to probe the role of these antigens in cell adhesion. Fluorescent versions of the peptides have been developed for optical imaging and radiolabeled versions have been used in single photon emission computed tomography (SPECT) and positron emission tomography (PET) in vivo imaging (3-6). A benefit in employing the radiolabeled peptides in SPECT and PET is that these imaging modalities are widely used in living systems and offer deep tissue sensitivity. Radiolabeled peptides, however, often exhibit poor stability and high kidney uptake in vivo. Conversely, optical imaging is sensitive and offers good spatial resolution, but is not useful for deep tissue penetration and is semi-quantitative. Thus, multimodality imaging that relies on the strengths of both radio- and optical- imaging is a current focus for development of new in vivo imaging agents. We propose a novel means to improve the efficacy of radiolabeled and fluorescently labeled peptides, including our lectin/carbohydrate- targeting peptides, by displaying the targeting epitopes on small ~29 amino acid cyclic plant protein scaffolds known as cyclotides. Cyclotides are extremely stable molecules with long serum half-lives and low kidney uptake (7). More than one copy of the peptide can be engineered into the cyclotide loops, thus increasing the avidity of the peptide construct for its target.« less

Cognitive Radio will revolutionize American transportation

ScienceCinema

None

2018-02-07

Cognitive Radio will revolutionize American transportation. Through smart technology, it will anticipate user needs; detect available bandwidths and frequencies then seamlessly connect vehicles, infrastructures, and consumer devices; and it will support the Department of Transportation IntelliDrive Program, helping researchers, auto manufacturers, and Federal and State officials advance the connectivity of US transportation systems for improved safety, mobility, and environmental conditions. Using cognitive radio, a commercial vehicle will know its driver, onboard freight and destination route. Drivers will save time and resources communicating with automatic toll booths and know ahead of time whether to stop at a weigh station or keep rolling. At accident scenes, cognitive radio sensors on freight and transportation modes can alert emergency personnel and measure on-site, real-time conditions such as a chemical leak. The sensors will connect freight to industry, relaying shipment conditions and new delivery schedules. For industry or military purposes, cognitive radio will enable real-time freight tracking around the globe and its sensory technology can help prevent cargo theft or tampering by alerting shipper and receiver if freight is tampered with while en route. For the average consumer, a vehicle will tailor the transportation experience to the passenger such as delivering age-appropriate movies via satellite. Cognitive radio will enhance transportation safety by continually sensing what is important to the user adapting to its environment and incoming information, and proposing solutions that improve mobility and quality of life.

Stage-directed individualized therapy in esophageal cancer.

PubMed

Goense, Lucas; van Rossum, Peter S N; Kandioler, Daniela; Ruurda, Jelle P; Goh, Khean-Lee; Luyer, Misha D; Krasna, Mark J; van Hillegersberg, Richard

2016-10-01

Esophageal cancer is the eighth most common cancer worldwide, and the incidence of esophageal carcinoma is rapidly increasing. With the advent of new staging and treatment techniques, esophageal cancer can now be managed through various strategies. A good understanding of the advances and limitations of new staging techniques and how these can guide in individualizing treatment is important to improve outcomes for esophageal cancer patients. This paper outlines the recent progress in staging and treatment of esophageal cancer, with particularly attention to endoscopic techniques for early-stage esophageal cancer, multimodality treatment for locally advanced esophageal cancer, assessment of response to neoadjuvant treatment, and the role of cervical lymph node dissection. Furthermore, advances in robot-assisted surgical techniques and postoperative recovery protocols that may further improve outcomes after esophagectomy are discussed. © 2016 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals Inc. on behalf of The New York Academy of Sciences.

Integrated Imaging and Vision Techniques for Industrial Inspection: A Special Issue on Machine Vision and Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Zheng; Ukida, H.; Ramuhalli, Pradeep

2010-06-05

Imaging- and vision-based techniques play an important role in industrial inspection. The sophistication of the techniques assures high- quality performance of the manufacturing process through precise positioning, online monitoring, and real-time classification. Advanced systems incorporating multiple imaging and/or vision modalities provide robust solutions to complex situations and problems in industrial applications. A diverse range of industries, including aerospace, automotive, electronics, pharmaceutical, biomedical, semiconductor, and food/beverage, etc., have benefited from recent advances in multi-modal imaging, data fusion, and computer vision technologies. Many of the open problems in this context are in the general area of image analysis methodologies (preferably in anmore » automated fashion). This editorial article introduces a special issue of this journal highlighting recent advances and demonstrating the successful applications of integrated imaging and vision technologies in industrial inspection.« less

76 FR 6927 - Radio Experimentation and Market Trials Under Part 5 of the Commission's Rules and Streamlining...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-08

...In this document, the Commission seeks to promote innovation and efficiency in spectrum use in the Experimental Radio Service (ERS). For many years, the ERS has provided fertile ground for testing innovative ideas that have led to new services and new devices for all sectors of the economy. The Commission proposes to leverage the power of experimental radio licensing to accelerate the rate at which these ideas transform from prototypes to consumer devices and services. Its goal is to inspire researchers to dream, discover and deliver the innovations that push the boundaries of the broadband ecosystem. The resulting advancements in devices and services available to the American public and greater spectrum efficiency over the long term will promote economic growth, global competitiveness, and a better way of life for all Americans.

Pulsar Search Results from the Arecibo Remote Command Center

NASA Astrophysics Data System (ADS)

Rodriguez, Miguel; Stovall, Kevin; Banaszak, Shawn A.; Becker, Alison; Biwer, Christopher M.; Boehler, Keith; Caballero, Keeisi; Christy, Brian; Cohen, Stephanie; Crawford, Fronefield; Cuellar, Andres; Danford, Andrew; Percy Dartez, Louis; Day, David; Flanigan, Joseph D.; Fonrouge, Aldo; Gonzalez, Adolfo; Gustavson, Kathy; Handzo, Emma; Hinojosa, Jesus; Jenet, Fredrick A.; Kaplan, David L. A.; Lommen, Andrea N.; Longoria, Chasity; Lopez, Janine; Lunsford, Grady; Mahany, Nicolas; Martinez, Jose; Mata, Alberto; Miller, Andy; Murray, James; Pankow, Chris; Ramirez, Ivan; Reser, Jackie; Rojas, Pablo; Rohr, Matthew; Rolph, Kristina; Rose, Caitlin; Rudnik, Philip; Siemens, Xavier; Tellez, Andrea; Tillman, Nicholas; Walker, Arielle; Wells, Bradley L.; Zaldivar, Jonathan; Zermeno, Adrienne; Gbncc Consortium, Palfa Consortium, Gbtdrift Consortium, Ao327 Consortium

2015-01-01

This poster presents the pulsar discoveries made by students in the Arecibo Remote Command Center (ARCC) program. The ARCC program was started at the University of Texas - Brownsville (UTB) within the Center for Advanced Radio Astronomy (CARA) as a group of scientists, faculty, graduate, undergraduate, and high school students interested in astrophysics. It has since expanded to form other ARCC programs at the University of Wisconsin-Milwaukee (UWM) and Franklin and Marshall College (F&M). The students in the ARCC group control the world's largest radio telescopes to search and discover pulsars. Pulsars are exotic neutron stars that emit beams of electromagnetic radiation. ARCC students use a web application to view and rate the images of radio pulsar candidates based on their signal characteristics. To date, ARCC students have searched through thousands of candidates and have discovered 61 pulsars to date.

Advanced teleprocessing systems

NASA Astrophysics Data System (ADS)

Kleinrock, L.; Gerla, M.

1982-09-01

This Annual Technical Report covers research covering the period from October 1, 1981 to September 30, 1982. This contract has three primary designated research areas: packet radio systems, resource sharing and allocation, and distributed processing and control. This report contains abstracts of publications which summarize research results in these areas followed by the main body of the report which is devoted to a study of channel access protocols that are executed by the nodes of a network to schedule their transmissions on multi-access broadcast channel. In particular the main body consists of a Ph.D. dissertation, Channel Access Protocols for Multi-Hop Broadcast Packet Radio Networks. This work discusses some new channel access protocols useful for mobile radio networks. Included is an analysis of slotted ALOHA and some tight bounds on the performance of all possible protocols in a mobile environment.

Study of Current Practice and Future Advancements in Blood Management and Effectiveness of a Multimodality Training Program on Improving Transfusion Knowledge, Practice and Outcomes

DTIC Science & Technology

2012-08-01

to trauma, surgery or blood diseases such as anemia, hemophilia or sickle- cell disease. But transfusions carry risks. Current practices are often...Blood Management Topic 4: Diagnosis of Red cell disorders and oxygen carrying capacity Topic 5: Diagnosis of Disorders in homeostasis Topic 6...the Clinical Transfusion Medicine Committee of the AABB. Red Blood Cell Transfusion: A Clinical Practice Guideline From the AABB. Ann Intern Med

Clinical applications of imaging biomarkers. Part 2. The neurosurgeon's perspective

PubMed Central

Brodbelt, A

2011-01-01

Advances in imaging, including multivoxel spectroscopy, tractography, functional MRI and positron emission spectroscopy, are being used by neurosurgeons to target aggressive areas in gliomas, and to help identify tumour boundaries, functional areas and tracts. Neuro-oncological surgeons need to understand these techniques to help maximise tumour resection, while minimising morbidity in an attempt to improve the quality of patient outcome. This article reviews the evidence for the practical use of multimodal imaging in modern glioma surgery. PMID:22433829

Randomized trials and quality assurance in gastric cancer surgery.

PubMed

Dikken, Johan L; Cats, Annemieke; Verheij, Marcel; van de Velde, Cornelis J H

2013-03-01

A D2 lymphadenectomy can be considered standard of surgical care for advanced resectable gastric cancer. Currently, several multimodality strategies are used, including postoperative monochemotherapy in Asia, postoperative chemoradiotherapy in the United States, and perioperative chemotherapy in Europe. As the majority of gastric cancer patients are treated outside the framework of clinical trials, quality assurance programs, including referral to high-volume centers and clinical auditing are needed to improve gastric cancer care on a nationwide level. Copyright © 2012 Wiley Periodicals, Inc.

Can exercise suppress tumour growth in advanced prostate cancer patients with sclerotic bone metastases? A randomised, controlled study protocol examining feasibility, safety and efficacy.

PubMed

Hart, Nicolas H; Newton, Robert U; Spry, Nigel A; Taaffe, Dennis R; Chambers, Suzanne K; Feeney, Kynan T; Joseph, David J; Redfern, Andrew D; Ferguson, Tom; Galvão, Daniel A

2017-05-30

Exercise may positively alter tumour biology through numerous modulatory and regulatory mechanisms in response to a variety of modes and dosages, evidenced in preclinical models to date. Specifically, localised and systemic biochemical alterations produced during and following exercise may suppress tumour formation, growth and distribution by virtue of altered epigenetics and endocrine-paracrine activity. Given the impressive ability of targeted mechanical loading to interfere with metastasis-driven tumour formation in human osteolytic tumour cells, it is of equal interest to determine whether a similar effect is observed in sclerotic tumour cells. The study aims to (1) establish the feasibility and safety of a combined modular multimodal exercise programme with spinal isometric training in advanced prostate cancer patients with sclerotic bone metastases and (2) examine whether targeted and supervised exercise can suppress sclerotic tumour growth and activity in spinal metastases in humans. A single-blinded, two-armed, randomised, controlled and explorative phase I clinical trial combining spinal isometric training with a modular multimodal exercise programme in 40 men with advanced prostate cancer and stable sclerotic spinal metastases. Participants will be randomly assigned to (1) the exercise intervention or (2) usual medical care. The intervention arm will receive a 3-month, supervised and individually tailored modular multimodal exercise programme with spinal isometric training. Primary endpoints (feasibility and safety) and secondary endpoints (tumour morphology; biomarker activity; anthropometry; musculoskeletal health; adiposity; physical function; quality of life; anxiety; distress; fatigue; insomnia; physical activity levels) will be measured at baseline and following the intervention. Statistical analyses will include descriptive characteristics, t-tests, effect sizes and two-way (group × time) repeated-measures analysis of variance (or analysis of covariance) to examine differences between groups over time. The data-set will be primarily examined using an intention-to-treat approach with multiple imputations, followed by a secondary sensitivity analysis to ensure data robustness using a complete cases approach. Ethics approval was obtained from the Human Research Ethics Committee (HREC) of Edith Cowan University and the Sir Charles Gairdner and Osborne Park Health Care Group. If proven to be feasible and safe, this study will form the basis of future phase II and III trials in human patients with advanced cancer. To reach a maximum number of clinicians, practitioners, patients and scientists, outcomes will be disseminated through national and international clinical, conference and patient presentations, as well as publication in high-impact, peer-reviewed academic journals. ACTRN 12616000179437. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

A hardware and software architecture to deal with multimodal and collaborative interactions in multiuser virtual reality environments

NASA Astrophysics Data System (ADS)

Martin, P.; Tseu, A.; Férey, N.; Touraine, D.; Bourdot, P.

2014-02-01

Most advanced immersive devices provide collaborative environment within several users have their distinct head-tracked stereoscopic point of view. Combining with common used interactive features such as voice and gesture recognition, 3D mouse, haptic feedback, and spatialized audio rendering, these environments should faithfully reproduce a real context. However, even if many studies have been carried out on multimodal systems, we are far to definitively solve the issue of multimodal fusion, which consists in merging multimodal events coming from users and devices, into interpretable commands performed by the application. Multimodality and collaboration was often studied separately, despite of the fact that these two aspects share interesting similarities. We discuss how we address this problem, thought the design and implementation of a supervisor that is able to deal with both multimodal fusion and collaborative aspects. The aim of this supervisor is to ensure the merge of user's input from virtual reality devices in order to control immersive multi-user applications. We deal with this problem according to a practical point of view, because the main requirements of this supervisor was defined according to a industrial task proposed by our automotive partner, that as to be performed with multimodal and collaborative interactions in a co-located multi-user environment. In this task, two co-located workers of a virtual assembly chain has to cooperate to insert a seat into the bodywork of a car, using haptic devices to feel collision and to manipulate objects, combining speech recognition and two hands gesture recognition as multimodal instructions. Besides the architectural aspect of this supervisor, we described how we ensure the modularity of our solution that could apply on different virtual reality platforms, interactive contexts and virtual contents. A virtual context observer included in this supervisor in was especially designed to be independent to the content of the virtual scene of targeted application, and is use to report high-level interactive and collaborative events. This context observer allows the supervisor to merge these interactive and collaborative events, but is also used to deal with new issues coming from our observation of two co-located users in an immersive device performing this assembly task. We highlight the fact that when speech recognition features are provided to the two users, it is required to automatically detect according to the interactive context, whether the vocal instructions must be translated into commands that have to be performed by the machine, or whether they take a part of the natural communication necessary for collaboration. Information coming from this context observer that indicates a user is looking at its collaborator, is important to detect if the user is talking to its partner. Moreover, as the users are physically co-localised and head-tracking is used to provide high fidelity stereoscopic rendering, and natural walking navigation in the virtual scene, we have to deals with collision and screen occlusion between the co-located users in the physical work space. Working area and focus of each user, computed and reported by the context observer is necessary to prevent or avoid these situations.

Concept design of an 80-dual polarization element cryogenic phased array camera for the Arecibo Radio Telescope

NASA Astrophysics Data System (ADS)

Cortes-Medellin, German; Parshley, Stephen; Campbell, Donald B.; Warnick, Karl F.; Jeffs, Brian D.; Ganesh, Rajagopalan

2016-08-01

This paper presents the current concept design for ALPACA (Advanced L-Band Phased Array Camera for Arecibo) an L-Band cryo-phased array instrument proposed for the 305 m radio telescope of Arecibo. It includes the cryogenically cooled front-end with 160 low noise amplifiers, a RF-over-fiber signal transport and a digital beam former with an instantaneous bandwidth of 312.5 MHz per channel. The camera will digitally form 40 simultaneous beams inside the available field of view of the Arecibo telescope optics, with an expected system temperature goal of 30 K.

WE-H-206-03: Promises and Challenges of Benchtop X-Ray Fluorescence CT (XFCT) for Quantitative in Vivo Imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cho, S.

Lihong V. Wang: Photoacoustic tomography (PAT), combining non-ionizing optical and ultrasonic waves via the photoacoustic effect, provides in vivo multiscale functional, metabolic, and molecular imaging. Broad applications include imaging of the breast, brain, skin, esophagus, colon, vascular system, and lymphatic system in humans or animals. Light offers rich contrast but does not penetrate biological tissue in straight paths as x-rays do. Consequently, high-resolution pure optical imaging (e.g., confocal microscopy, two-photon microscopy, and optical coherence tomography) is limited to penetration within the optical diffusion limit (∼1 mm in the skin). Ultrasonic imaging, on the contrary, provides fine spatial resolution but suffersmore » from both poor contrast in early-stage tumors and strong speckle artifacts. In PAT, pulsed laser light penetrates tissue and generates a small but rapid temperature rise, which induces emission of ultrasonic waves due to thermoelastic expansion. The ultrasonic waves, orders of magnitude less scattering than optical waves, are then detected to form high-resolution images of optical absorption at depths up to 7 cm, conquering the optical diffusion limit. PAT is the only modality capable of imaging across the length scales of organelles, cells, tissues, and organs (up to whole-body small animals) with consistent contrast. This rapidly growing technology promises to enable multiscale biological research and accelerate translation from microscopic laboratory discoveries to macroscopic clinical practice. PAT may also hold the key to label-free early detection of cancer by in vivo quantification of hypermetabolism, the quintessential hallmark of malignancy. Learning Objectives: To understand the contrast mechanism of PAT To understand the multiscale applications of PAT Benjamin M. W. Tsui: Multi-modality molecular imaging instrumentation and techniques have been major developments in small animal imaging that has contributed significantly to biomedical research during the past decade. The initial development was an extension of clinical PET/CT and SPECT/CT from human to small animals and combine the unique functional information obtained from PET and SPECT with anatomical information provided by the CT in registered multi-modality images. The requirements to image a mouse whose size is an order of magnitude smaller than that of a human have spurred advances in new radiation detector technologies, novel imaging system designs and special image reconstruction and processing techniques. Examples are new detector materials and designs with high intrinsic resolution, multi-pinhole (MPH) collimator design for much improved resolution and detection efficiency compared to the conventional collimator designs in SPECT, 3D high-resolution and artifact-free MPH and sparse-view image reconstruction techniques, and iterative image reconstruction methods with system response modeling for resolution recovery and image noise reduction for much improved image quality. The spatial resolution of PET and SPECT has improved from ∼6–12 mm to ∼1 mm a few years ago to sub-millimeter today. A recent commercial small animal SPECT system has achieved a resolution of ∼0.25 mm which surpasses that of a state-of-art PET system whose resolution is limited by the positron range. More recently, multimodality SA PET/MRI and SPECT/MRI systems have been developed in research laboratories. Also, multi-modality SA imaging systems that include other imaging modalities such as optical and ultrasound are being actively pursued. In this presentation, we will provide a review of the development, recent advances and future outlook of multi-modality molecular imaging of small animals. Learning Objectives: To learn about the two major multi-modality molecular imaging techniques of small animals. To learn about the spatial resolution achievable by the molecular imaging systems for small animal today. To learn about the new multi-modality imaging instrumentation and techniques that are being developed. Sang Hyun Cho; X-ray fluorescence (XRF) imaging, such as x-ray fluorescence computed tomography (XFCT), offers unique capabilities for accurate identification and quantification of metals within the imaging objects. As a result, it has emerged as a promising quantitative imaging modality in recent years, especially in conjunction with metal-based imaging probes. This talk will familiarize the audience with the basic principles of XRF/XFCT imaging. It will also cover the latest development of benchtop XFCT technology. Additionally, the use of metallic nanoparticles such as gold nanoparticles, in conjunction with benchtop XFCT, will be discussed within the context of preclinical multimodal multiplexed molecular imaging. Learning Objectives: To learn the basic principles of XRF/XFCT imaging To learn the latest advances in benchtop XFCT development for preclinical imaging Funding support received from NIH and DOD; Funding support received from GE Healthcare; Funding support received from Siemens AX; Patent royalties received from GE Healthcare; L. Wang, Funding Support: NIH; COI: Microphotoacoustics; S. Cho, Yes: ;NIH/NCI grant R01CA155446 DOD/PCRP grant W81XWH-12-1-0198.« less

WE-H-206-01: Photoacoustic Tomography: Multiscale Imaging From Organelles to Patients by Ultrasonically Beating the Optical Diffusion Limit

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, L.

Lihong V. Wang: Photoacoustic tomography (PAT), combining non-ionizing optical and ultrasonic waves via the photoacoustic effect, provides in vivo multiscale functional, metabolic, and molecular imaging. Broad applications include imaging of the breast, brain, skin, esophagus, colon, vascular system, and lymphatic system in humans or animals. Light offers rich contrast but does not penetrate biological tissue in straight paths as x-rays do. Consequently, high-resolution pure optical imaging (e.g., confocal microscopy, two-photon microscopy, and optical coherence tomography) is limited to penetration within the optical diffusion limit (∼1 mm in the skin). Ultrasonic imaging, on the contrary, provides fine spatial resolution but suffersmore » from both poor contrast in early-stage tumors and strong speckle artifacts. In PAT, pulsed laser light penetrates tissue and generates a small but rapid temperature rise, which induces emission of ultrasonic waves due to thermoelastic expansion. The ultrasonic waves, orders of magnitude less scattering than optical waves, are then detected to form high-resolution images of optical absorption at depths up to 7 cm, conquering the optical diffusion limit. PAT is the only modality capable of imaging across the length scales of organelles, cells, tissues, and organs (up to whole-body small animals) with consistent contrast. This rapidly growing technology promises to enable multiscale biological research and accelerate translation from microscopic laboratory discoveries to macroscopic clinical practice. PAT may also hold the key to label-free early detection of cancer by in vivo quantification of hypermetabolism, the quintessential hallmark of malignancy. Learning Objectives: To understand the contrast mechanism of PAT To understand the multiscale applications of PAT Benjamin M. W. Tsui: Multi-modality molecular imaging instrumentation and techniques have been major developments in small animal imaging that has contributed significantly to biomedical research during the past decade. The initial development was an extension of clinical PET/CT and SPECT/CT from human to small animals and combine the unique functional information obtained from PET and SPECT with anatomical information provided by the CT in registered multi-modality images. The requirements to image a mouse whose size is an order of magnitude smaller than that of a human have spurred advances in new radiation detector technologies, novel imaging system designs and special image reconstruction and processing techniques. Examples are new detector materials and designs with high intrinsic resolution, multi-pinhole (MPH) collimator design for much improved resolution and detection efficiency compared to the conventional collimator designs in SPECT, 3D high-resolution and artifact-free MPH and sparse-view image reconstruction techniques, and iterative image reconstruction methods with system response modeling for resolution recovery and image noise reduction for much improved image quality. The spatial resolution of PET and SPECT has improved from ∼6–12 mm to ∼1 mm a few years ago to sub-millimeter today. A recent commercial small animal SPECT system has achieved a resolution of ∼0.25 mm which surpasses that of a state-of-art PET system whose resolution is limited by the positron range. More recently, multimodality SA PET/MRI and SPECT/MRI systems have been developed in research laboratories. Also, multi-modality SA imaging systems that include other imaging modalities such as optical and ultrasound are being actively pursued. In this presentation, we will provide a review of the development, recent advances and future outlook of multi-modality molecular imaging of small animals. Learning Objectives: To learn about the two major multi-modality molecular imaging techniques of small animals. To learn about the spatial resolution achievable by the molecular imaging systems for small animal today. To learn about the new multi-modality imaging instrumentation and techniques that are being developed. Sang Hyun Cho; X-ray fluorescence (XRF) imaging, such as x-ray fluorescence computed tomography (XFCT), offers unique capabilities for accurate identification and quantification of metals within the imaging objects. As a result, it has emerged as a promising quantitative imaging modality in recent years, especially in conjunction with metal-based imaging probes. This talk will familiarize the audience with the basic principles of XRF/XFCT imaging. It will also cover the latest development of benchtop XFCT technology. Additionally, the use of metallic nanoparticles such as gold nanoparticles, in conjunction with benchtop XFCT, will be discussed within the context of preclinical multimodal multiplexed molecular imaging. Learning Objectives: To learn the basic principles of XRF/XFCT imaging To learn the latest advances in benchtop XFCT development for preclinical imaging Funding support received from NIH and DOD; Funding support received from GE Healthcare; Funding support received from Siemens AX; Patent royalties received from GE Healthcare; L. Wang, Funding Support: NIH; COI: Microphotoacoustics; S. Cho, Yes: ;NIH/NCI grant R01CA155446 DOD/PCRP grant W81XWH-12-1-0198.« less

A preliminary scheme to modify the reception characteristics of a log-periodic antenna within its operating bandwidth

NASA Astrophysics Data System (ADS)

Kishore, P.; Kathiravan, C.

The level of radio emission from the Sun and other celestial sources that we receive on the Earth is very low when compared to those generated here (e.g. by TV and radio broadcasting stations, engines of automobiles and industrial equipment). Therefore, it requires technically advanced systems to detect those weak emissions in order to study their characteristics, generation mechanisms, etc. - one of the interests of human race to enhance its knowledge about space and its entities. Although inevitable and became part of life, the civilian radio broadcast, communication networks are capable of affecting such observations directly. Studies show that eliminating such interferences at an early stage improves not only the analyses but also the reliability of the results. Towards this an attempt is made to alter the characteristics of an antenna since it is the foremost component of any radio receiver system. The tests are made with a Log-periodic dipole antenna (LPDA) and the changes in the reception characteristics over a few set of undesired frequency bands are discussed here.

A comme... ("A" as in...).

ERIC Educational Resources Information Center

Foucher, Bernard; And Others

1981-01-01

Discusses the pedagogical implications, for a French class, of the following: (1) a puzzle-like game for text reconstruction; (2) use of gossip-column letters in advanced classes; (3) use of radio news and newspaper titles; and (4) classroom space utilization favoring spontaneous communication. (AMH)

47 CFR 5.54 - Types of authorizations available.

Code of Federal Regulations, 2013 CFR

2013-10-01

... experimentation for the development and advancement of new broadcast technology, equipment, systems or services... testing experimental radio license. This type of license is issued to hospitals and health care institutions that demonstrate expertise in testing and operation of experimental medical devices that use...

47 CFR 5.54 - Types of authorizations available.

Code of Federal Regulations, 2014 CFR

2014-10-01

... experimentation for the development and advancement of new broadcast technology, equipment, systems or services... testing experimental radio license. This type of license is issued to hospitals and health care institutions that demonstrate expertise in testing and operation of experimental medical devices that use...

47 CFR 74.102 - Uses of experimental broadcast stations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Section 74.102 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES... station will be issued for the purposes of carrying on research and experimentation for the development and advancement of new broadcast technology, equipment, systems or services which are more extensive...

47 CFR 74.102 - Uses of experimental broadcast stations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Section 74.102 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES... station will be issued for the purposes of carrying on research and experimentation for the development and advancement of new broadcast technology, equipment, systems or services which are more extensive...

47 CFR 74.102 - Uses of experimental broadcast stations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Section 74.102 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES... station will be issued for the purposes of carrying on research and experimentation for the development and advancement of new broadcast technology, equipment, systems or services which are more extensive...

Optimal Symmetric Multimodal Templates and Concatenated Random Forests for Supervised Brain Tumor Segmentation (Simplified) with ANTsR.

PubMed

Tustison, Nicholas J; Shrinidhi, K L; Wintermark, Max; Durst, Christopher R; Kandel, Benjamin M; Gee, James C; Grossman, Murray C; Avants, Brian B

2015-04-01

Segmenting and quantifying gliomas from MRI is an important task for diagnosis, planning intervention, and for tracking tumor changes over time. However, this task is complicated by the lack of prior knowledge concerning tumor location, spatial extent, shape, possible displacement of normal tissue, and intensity signature. To accommodate such complications, we introduce a framework for supervised segmentation based on multiple modality intensity, geometry, and asymmetry feature sets. These features drive a supervised whole-brain and tumor segmentation approach based on random forest-derived probabilities. The asymmetry-related features (based on optimal symmetric multimodal templates) demonstrate excellent discriminative properties within this framework. We also gain performance by generating probability maps from random forest models and using these maps for a refining Markov random field regularized probabilistic segmentation. This strategy allows us to interface the supervised learning capabilities of the random forest model with regularized probabilistic segmentation using the recently developed ANTsR package--a comprehensive statistical and visualization interface between the popular Advanced Normalization Tools (ANTs) and the R statistical project. The reported algorithmic framework was the top-performing entry in the MICCAI 2013 Multimodal Brain Tumor Segmentation challenge. The challenge data were widely varying consisting of both high-grade and low-grade glioma tumor four-modality MRI from five different institutions. Average Dice overlap measures for the final algorithmic assessment were 0.87, 0.78, and 0.74 for "complete", "core", and "enhanced" tumor components, respectively.

Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography (Conference Presentation)

NASA Astrophysics Data System (ADS)

Tang, Qinggong; Frank, Aaron; Wang, Jianting; Chen, Chao-wei; Jin, Lily; Lin, Jon; Chan, Joanne M.; Chen, Yu

2016-03-01

Early detection of neoplastic changes remains a critical challenge in clinical cancer diagnosis and treatment. Many cancers arise from epithelial layers such as those of the gastrointestinal (GI) tract. Current standard endoscopic technology is unable to detect those subsurface lesions. Since cancer development is associated with both morphological and molecular alterations, imaging technologies that can quantitative image tissue's morphological and molecular biomarkers and assess the depth extent of a lesion in real time, without the need for tissue excision, would be a major advance in GI cancer diagnostics and therapy. In this research, we investigated the feasibility of multi-modal optical imaging including high-resolution optical coherence tomography (OCT) and depth-resolved high-sensitivity fluorescence laminar optical tomography (FLOT) for structural and molecular imaging. APC (adenomatous polyposis coli) mice model were imaged using OCT and FLOT and the correlated histopathological diagnosis was obtained. Quantitative structural (the scattering coefficient) and molecular imaging parameters (fluorescence intensity) from OCT and FLOT images were developed for multi-parametric analysis. This multi-modal imaging method has demonstrated the feasibility for more accurate diagnosis with 87.4% (87.3%) for sensitivity (specificity) which gives the most optimal diagnosis (the largest area under receiver operating characteristic (ROC) curve). This project results in a new non-invasive multi-modal imaging platform for improved GI cancer detection, which is expected to have a major impact on detection, diagnosis, and characterization of GI cancers, as well as a wide range of epithelial cancers.

Nanoelectronics enabled chronic multimodal neural platform in a mouse ischemic model.

PubMed

Luan, Lan; Sullender, Colin T; Li, Xue; Zhao, Zhengtuo; Zhu, Hanlin; Wei, Xiaoling; Xie, Chong; Dunn, Andrew K

2018-02-01

Despite significant advancements of optical imaging techniques for mapping hemodynamics in small animal models, it remains challenging to combine imaging with spatially resolved electrical recording of individual neurons especially for longitudinal studies. This is largely due to the strong invasiveness to the living brain from the penetrating electrodes and their limited compatibility with longitudinal imaging. We implant arrays of ultraflexible nanoelectronic threads (NETs) in mice for neural recording both at the brain surface and intracortically, which maintain great tissue compatibility chronically. By mounting a cranial window atop of the NET arrays that allows for chronic optical access, we establish a multimodal platform that combines spatially resolved electrical recording of neural activity and laser speckle contrast imaging (LSCI) of cerebral blood flow (CBF) for longitudinal studies. We induce peri-infarct depolarizations (PIDs) by targeted photothrombosis, and show the ability to detect its occurrence and propagation through spatiotemporal variations in both extracellular potentials and CBF. We also demonstrate chronic tracking of single-unit neural activity and CBF over days after photothrombosis, from which we observe reperfusion and increased firing rates. This multimodal platform enables simultaneous mapping of neural activity and hemodynamic parameters at the microscale for quantitative, longitudinal comparisons with minimal perturbation to the baseline neurophysiology. The ability to spatiotemporally resolve and chronically track CBF and neural electrical activity in the same living brain region has broad applications for studying the interplay between neural and hemodynamic responses in health and in cerebrovascular and neurological pathologies. Copyright © 2017 Elsevier B.V. All rights reserved.

Stochastic Particle Acceleration in the Hot Spots of FRII Radio Galaxies

NASA Astrophysics Data System (ADS)

Liu, Siming; Fan, Z.; Wang, J.; Fryer, C. L.; Li, H.

2007-12-01

Chandra, XMM-Newton, and HST observations of FRII radio galaxies, in combination with traditional radio studies, have advanced our understanding of the nature of jets, hot spots, and lobes significantly. The observed radio to optical emission has been attributed to the synchrotron processes. The X-ray emission can be produced through synchrotron, synchrotron self-Comptonization, and inverse Comptonization of the CMB or other background photos. Phenomenologically modelings of the observed broadband spectra have led to good constraints on the magnetic field and electron distribution. However, the matter and energy contents of the relativistic outflows driven by the central black holes, which power these sources, are still not well-constrained, and we also lack an understanding of the physical processes that determine the energy partition between the electrons and the magnetic field, the low energy cutoff of the electron spectrum, and the electron acceleration rate in these strongly magnetized relativistic plasmas. In the context of stochastic particle acceleration, we propose a model for the hot spots of radio galaxies and show how it may help us to address the above issues. This work was funded in part under the auspices of the US Department of Energy, and supported by its contract W-7405-ENG-36 to Los Alamos National Laboratory.

Recent Advances in Radio and Optical Propagation for Modern Communications, Navigation and Detection Systems

DTIC Science & Technology

1978-04-01

of coherent detection techniques (e.g. laser and optical heterodyning, sensitive to phase fluctuations caused by atmospheric turbulence). The...ATMOSPHERIC OPTICAL EFFECTS 2.1 Atmospheric Refraction The index of refraction n = c/v, with c = velocity of propagation in a vacuum and v ’n air , is... oscillating electrons reradiate and the net effect is to change the phase of the advancing wave. When sufficient molecules are present the moving electrons

[Cytoprotection with amifostine in radiotherapy or radio-chemotherapy of head and neck tumors].

PubMed

Altmann, S; Hoffmanns, H

1999-11-01

A considerable amount of experimental and clinical data prove the cytoprotective effect of amifostine on normal tissue exposed to different types of antineoplastic treatments. The present study examines its influence on the short-term toxicity of either radiotherapy alone or combined radio-chemotherapy in patients with advanced head and neck cancer. Twenty-three patients with advanced head and neck cancer, mainly Stage III and IV, were treated with preoperative radiation (n = 1), pre- as well as postoperative radiotherapy (n = 5), postoperative radiation (n = 9) or combined postoperative radio-chemotherapy (n = 6). Before each radiation application a total dose of 500 mg amifostine was administered intravenously over 15 minutes. The documentation of this unselected patient group was compared retrospectively to a historical control group comprising 17 patients. In 15 patients (65%) of the amifostine group, therapy induced side effects such as mucositis and dermatitis of WHO Grade < or = 2 were detected, requiring interruptions of the radiotherapy (mean: 6.5, maximum 17 days). No mucosa or dermatologic toxicity of WHO Grade 3 or 4 was observed in this group. Significantly more acute toxicity was detected in the historical control group. Stomatitis or epitheliolysis of WHO Grade 3 occurred in 7 patients (41%). The side effects induced by the antineoplastic therapy caused an interruption of treatment in 15 patients (88%) (mean: 16, maximum 40 days; p = 0.0016). The application of amifostine before each radiation treatment seems to result in a distinct reduction of short-term toxicity of radiotherapy or combined radio-chemotherapy in patients with head and neck cancer, allowing for a better adherence to the planned radiation time schedule.

Advanced Multimodal Solutions for Information Presentation

NASA Technical Reports Server (NTRS)

Wenzel, Elizabeth M.; Godfroy-Cooper, Martine

2018-01-01

High-workload, fast-paced, and degraded sensory environments are the likeliest candidates to benefit from multimodal information presentation. For example, during EVA (Extra-Vehicular Activity) and telerobotic operations, the sensory restrictions associated with a space environment provide a major challenge to maintaining the situation awareness (SA) required for safe operations. Multimodal displays hold promise to enhance situation awareness and task performance by utilizing different sensory modalities and maximizing their effectiveness based on appropriate interaction between modalities. During EVA, the visual and auditory channels are likely to be the most utilized with tasks such as monitoring the visual environment, attending visual and auditory displays, and maintaining multichannel auditory communications. Previous studies have shown that compared to unimodal displays (spatial auditory or 2D visual), bimodal presentation of information can improve operator performance during simulated extravehicular activity on planetary surfaces for tasks as diverse as orientation, localization or docking, particularly when the visual environment is degraded or workload is increased. Tactile displays offer a third sensory channel that may both offload information processing effort and provide a means to capture attention when urgently required. For example, recent studies suggest that including tactile cues may result in increased orientation and alerting accuracy, improved task response time and decreased workload, as well as provide self-orientation cues in microgravity on the ISS (International Space Station). An important overall issue is that context-dependent factors like task complexity, sensory degradation, peripersonal vs. extrapersonal space operations, workload, experience level, and operator fatigue tend to vary greatly in complex real-world environments and it will be difficult to design a multimodal interface that performs well under all conditions. As a possible solution, adaptive systems have been proposed in which the information presented to the user changes as a function of taskcontext-dependent factors. However, this presupposes that adequate methods for detecting andor predicting such factors are developed. Further, research in adaptive systems for aviation suggests that they can sometimes serve to increase workload and reduce situational awareness. It will be critical to develop multimodal display guidelines that include consideration of smart systems that can select the best display method for a particular contextsituation.The scope of the current work is an analysis of potential multimodal display technologies for long duration missions and, in particular, will focus on their potential role in EVA activities. The review will address multimodal (combined visual, auditory andor tactile) displays investigated by NASA, industry, and DoD (Dept. of Defense). It also considers the need for adaptive information systems to accommodate a variety of operational contexts such as crew status (e.g., fatigue, workload level) and task environment (e.g., EVA, habitat, rover, spacecraft). Current approaches to guidelines and best practices for combining modalities for the most effective information displays are also reviewed. Potential issues in developing interface guidelines for the Exploration Information System (EIS) are briefly considered.

Alternative therapies for metastatic breast cancer: multimodal approach targeting tumor cell heterogeneity.

PubMed

Sambi, Manpreet; Haq, Sabah; Samuel, Vanessa; Qorri, Bessi; Haxho, Fiona; Hill, Kelli; Harless, William; Szewczuk, Myron R

2017-01-01

One of the primary challenges in developing effective therapies for malignant tumors is the specific targeting of a heterogeneous cancer cell population within the tumor. The cancerous tumor is made up of a variety of distinct cells with specialized receptors and proteins that could potentially be viable targets for drugs. In addition, the diverse signals from the local microenvironment may also contribute to the induction of tumor growth and metastasis. Collectively, these factors must be strategically studied and targeted in order to develop an effective treatment protocol. Targeted multimodal approaches need to be strategically studied in order to develop a treatment protocol that is successful in controlling tumor growth and preventing metastatic burden. Breast cancer, in particular, presents a unique problem because of the variety of subtypes of cancer that can arise and the multiple drug targets that could be exploited. For example, the tumor stage and subtypes often dictate the appropriate treatment regimen. Alternate multimodal therapies should consider the importance of time-dependent drug administration, as well as targeting the local and systemic tumor environment. Many reviews and papers have briefly touched on the clinical implications of this cellular heterogeneity; however, there has been very little discussion on the development of study models that reflect this diversity and on multimodal therapies that could target these subpopulations. Here, we summarize the current understanding of the origins of intratumoral heterogeneity in breast cancer subtypes, and its implications for tumor progression, metastatic potential, and treatment regimens. We also discuss the advantages and disadvantages of utilizing specific breast cancer models for research, including in vitro monolayer systems and three-dimensional mammospheres, as well as in vivo murine models that may have the capacity to encompass this heterogeneity. Lastly, we summarize some of the current advancements in the development of multitarget therapeutics that have shown promising results in clinical and preclinical studies when used alone or in combination with traditional regimens of surgery, chemotherapy, and/or radiation.

Image-guided thoracic surgery in the hybrid operation room.

PubMed

Ujiie, Hideki; Effat, Andrew; Yasufuku, Kazuhiro

2017-01-01

There has been an increase in the use of image-guided technology to facilitate minimally invasive therapy. The next generation of minimally invasive therapy is focused on advancement and translation of novel image-guided technologies in therapeutic interventions, including surgery, interventional pulmonology, radiation therapy, and interventional laser therapy. To establish the efficacy of different minimally invasive therapies, we have developed a hybrid operating room, known as the guided therapeutics operating room (GTx OR) at the Toronto General Hospital. The GTx OR is equipped with multi-modality image-guidance systems, which features a dual source-dual energy computed tomography (CT) scanner, a robotic cone-beam CT (CBCT)/fluoroscopy, high-performance endobronchial ultrasound system, endoscopic surgery system, near-infrared (NIR) fluorescence imaging system, and navigation tracking systems. The novel multimodality image-guidance systems allow physicians to quickly, and accurately image patients while they are on the operating table. This yield improved outcomes since physicians are able to use image guidance during their procedures, and carry out innovative multi-modality therapeutics. Multiple preclinical translational studies pertaining to innovative minimally invasive technology is being developed in our guided therapeutics laboratory (GTx Lab). The GTx Lab is equipped with similar technology, and multimodality image-guidance systems as the GTx OR, and acts as an appropriate platform for translation of research into human clinical trials. Through the GTx Lab, we are able to perform basic research, such as the development of image-guided technologies, preclinical model testing, as well as preclinical imaging, and then translate that research into the GTx OR. This OR allows for the utilization of new technologies in cancer therapy, including molecular imaging, and other innovative imaging modalities, and therefore enables a better quality of life for patients, both during and after the procedure. In this article, we describe capabilities of the GTx systems, and discuss the first-in-human technologies used, and evaluated in GTx OR.

Multimodal imaging evaluation in staging of rectal cancer

PubMed Central

Heo, Suk Hee; Kim, Jin Woong; Shin, Sang Soo; Jeong, Yong Yeon; Kang, Heoung-Keun

2014-01-01

Rectal cancer is a common cancer and a major cause of mortality in Western countries. Accurate staging is essential for determining the optimal treatment strategies and planning appropriate surgical procedures to control rectal cancer. Endorectal ultrasonography (EUS) is suitable for assessing the extent of tumor invasion, particularly in early-stage or superficial rectal cancer cases. In advanced cases with distant metastases, computed tomography (CT) is the primary approach used to evaluate the disease. Magnetic resonance imaging (MRI) is often used to assess preoperative staging and the circumferential resection margin involvement, which assists in evaluating a patient’s risk of recurrence and their optimal therapeutic strategy. Positron emission tomography (PET)-CT may be useful in detecting occult synchronous tumors or metastases at the time of initial presentation. Restaging after neoadjuvant chemoradiotherapy (CRT) remains a challenge with all modalities because it is difficult to reliably differentiate between the tumor mass and other radiation-induced changes in the images. EUS does not appear to have a useful role in post-therapeutic response assessments. Although CT is most commonly used to evaluate treatment responses, its utility for identifying and following-up metastatic lesions is limited. Preoperative high-resolution MRI in combination with diffusion-weighted imaging, and/or PET-CT could provide valuable prognostic information for rectal cancer patients with locally advanced disease receiving preoperative CRT. Based on these results, we conclude that a combination of multimodal imaging methods should be used to precisely assess the restaging of rectal cancer following CRT. PMID:24764662

URSI and Nachrichtentechnische Gesellschaft, General Session, Kleinheubach, West Germany, Oct. 6-10, 1986, Reports

NASA Astrophysics Data System (ADS)

Factors affecting the atmospheric propagation of EM waves, research on the ionosphere, and advances in radar and communications technology are examined in reviews and reports. Topics discussed include refraction corrections for radio astronomy and geodesy, speckle masking, radar studies of atmospheric motion, EISCAT measurements in the polar electrojet, active experiments in the polar ionosphere, and dispersion relations for drift-Alfven and drift-acoustic waves. Consideration is given to a microcomputer prediction system for HF communications over Europe, frequency determination of a hyperfine line of CH4 at 88 THz, multipath propagation in digital mobile communication, a robust digital voice transmission technique for land mobile radio, CMOS LSI for digital signal processing in mobile radio equipment, the representation of EM fields by dyadic Green functions, scalarization of Maxwell's equations for anisotropic media, and satellite antennas for land vehicles and aircraft.

Radio frequency analog electronics based on carbon nanotube transistors

PubMed Central

Kocabas, Coskun; Kim, Hoon-sik; Banks, Tony; Rogers, John A.; Pesetski, Aaron A.; Baumgardner, James E.; Krishnaswamy, S. V.; Zhang, Hong

2008-01-01

The potential to exploit single-walled carbon nanotubes (SWNTs) in advanced electronics represents a continuing, major source of interest in these materials. However, scalable integration of SWNTs into circuits is challenging because of difficulties in controlling the geometries, spatial positions, and electronic properties of individual tubes. We have implemented solutions to some of these challenges to yield radio frequency (RF) SWNT analog electronic devices, such as narrow band amplifiers operating in the VHF frequency band with power gains as high as 14 dB. As a demonstration, we fabricated nanotube transistor radios, in which SWNT devices provide all of the key functions, including resonant antennas, fixed RF amplifiers, RF mixers, and audio amplifiers. These results represent important first steps to practical implementation of SWNTs in high-speed analog circuits. Comparison studies indicate certain performance advantages over silicon and capabilities that complement those in existing compound semiconductor technologies. PMID:18227509

Black hole physics. Black hole lightning due to particle acceleration at subhorizon scales.

PubMed

Aleksić, J; Ansoldi, S; Antonelli, L A; Antoranz, P; Babic, A; Bangale, P; Barrio, J A; Becerra González, J; Bednarek, W; Bernardini, E; Biasuzzi, B; Biland, A; Blanch, O; Bonnefoy, S; Bonnoli, G; Borracci, F; Bretz, T; Carmona, E; Carosi, A; Colin, P; Colombo, E; Contreras, J L; Cortina, J; Covino, S; Da Vela, P; Dazzi, F; De Angelis, A; De Caneva, G; De Lotto, B; de Oña Wilhelmi, E; Delgado Mendez, C; Dominis Prester, D; Dorner, D; Doro, M; Einecke, S; Eisenacher, D; Elsaesser, D; Fonseca, M V; Font, L; Frantzen, K; Fruck, C; Galindo, D; García López, R J; Garczarczyk, M; Garrido Terrats, D; Gaug, M; Godinović, N; González Muñoz, A; Gozzini, S R; Hadasch, D; Hanabata, Y; Hayashida, M; Herrera, J; Hildebrand, D; Hose, J; Hrupec, D; Idec, W; Kadenius, V; Kellermann, H; Kodani, K; Konno, Y; Krause, J; Kubo, H; Kushida, J; La Barbera, A; Lelas, D; Lewandowska, N; Lindfors, E; Lombardi, S; Longo, F; López, M; López-Coto, R; López-Oramas, A; Lorenz, E; Lozano, I; Makariev, M; Mallot, K; Maneva, G; Mankuzhiyil, N; Mannheim, K; Maraschi, L; Marcote, B; Mariotti, M; Martínez, M; Mazin, D; Menzel, U; Miranda, J M; Mirzoyan, R; Moralejo, A; Munar-Adrover, P; Nakajima, D; Niedzwiecki, A; Nilsson, K; Nishijima, K; Noda, K; Orito, R; Overkemping, A; Paiano, S; Palatiello, M; Paneque, D; Paoletti, R; Paredes, J M; Paredes-Fortuny, X; Persic, M; Poutanen, J; Prada Moroni, P G; Prandini, E; Puljak, I; Reinthal, R; Rhode, W; Ribó, M; Rico, J; Rodriguez Garcia, J; Rügamer, S; Saito, T; Saito, K; Satalecka, K; Scalzotto, V; Scapin, V; Schultz, C; Schweizer, T; Shore, S N; Sillanpää, A; Sitarek, J; Snidaric, I; Sobczynska, D; Spanier, F; Stamatescu, V; Stamerra, A; Steinbring, T; Storz, J; Strzys, M; Takalo, L; Takami, H; Tavecchio, F; Temnikov, P; Terzić, T; Tescaro, D; Teshima, M; Thaele, J; Tibolla, O; Torres, D F; Toyama, T; Treves, A; Uellenbeck, M; Vogler, P; Zanin, R; Kadler, M; Schulz, R; Ros, E; Bach, U; Krauß, F; Wilms, J

2014-11-28

Supermassive black holes with masses of millions to billions of solar masses are commonly found in the centers of galaxies. Astronomers seek to image jet formation using radio interferometry but still suffer from insufficient angular resolution. An alternative method to resolve small structures is to measure the time variability of their emission. Here we report on gamma-ray observations of the radio galaxy IC 310 obtained with the MAGIC (Major Atmospheric Gamma-ray Imaging Cherenkov) telescopes, revealing variability with doubling time scales faster than 4.8 min. Causality constrains the size of the emission region to be smaller than 20% of the gravitational radius of its central black hole. We suggest that the emission is associated with pulsar-like particle acceleration by the electric field across a magnetospheric gap at the base of the radio jet. Copyright © 2014, American Association for the Advancement of Science.

GLOBECOM '85 - Global Telecommunications Conference, New Orleans, LA, December 2-5, 1985, Conference Record. Volumes 1, 2, & 3

NASA Astrophysics Data System (ADS)

Various papers on global telecommunications are presented. The general topics addressed include: multiservice integration with optical fibers, multicompany owned telecommunication networks, softworks quality and reliability, advanced on-board processing, impact of new services and systems on operations and maintenance, analytical studies of protocols for data communication networks, topics in packet radio networking, CCITT No. 7 to support new services, document processing and communication, antenna technology and system aspects in satellite communications. Also considered are: communication systems modelling methodology, experimental integrated local area voice/data nets, spread spectrum communications, motion video at the DS-0 rate, optical and data communications, intelligent work stations, switch performance analysis, novel radio communication systems, wireless local networks, ISDN services, LAN communication protocols, user-system interface, radio propagation and performance, mobile satellite system, software for computer networks, VLSI for ISDN terminals, quality management, man-machine interfaces in switching, and local area network performance.

A Design of Irregular Grid Map for Large-Scale Wi-Fi LAN Fingerprint Positioning Systems

PubMed Central

Kim, Jae-Hoon; Min, Kyoung Sik; Yeo, Woon-Young

2014-01-01

The rapid growth of mobile communication and the proliferation of smartphones have drawn significant attention to location-based services (LBSs). One of the most important factors in the vitalization of LBSs is the accurate position estimation of a mobile device. The Wi-Fi positioning system (WPS) is a new positioning method that measures received signal strength indication (RSSI) data from all Wi-Fi access points (APs) and stores them in a large database as a form of radio fingerprint map. Because of the millions of APs in urban areas, radio fingerprints are seriously contaminated and confused. Moreover, the algorithmic advances for positioning face computational limitation. Therefore, we present a novel irregular grid structure and data analytics for efficient fingerprint map management. The usefulness of the proposed methodology is presented using the actual radio fingerprint measurements taken throughout Seoul, Korea. PMID:25302315

A design of irregular grid map for large-scale Wi-Fi LAN fingerprint positioning systems.

PubMed

Kim, Jae-Hoon; Min, Kyoung Sik; Yeo, Woon-Young

2014-01-01

The rapid growth of mobile communication and the proliferation of smartphones have drawn significant attention to location-based services (LBSs). One of the most important factors in the vitalization of LBSs is the accurate position estimation of a mobile device. The Wi-Fi positioning system (WPS) is a new positioning method that measures received signal strength indication (RSSI) data from all Wi-Fi access points (APs) and stores them in a large database as a form of radio fingerprint map. Because of the millions of APs in urban areas, radio fingerprints are seriously contaminated and confused. Moreover, the algorithmic advances for positioning face computational limitation. Therefore, we present a novel irregular grid structure and data analytics for efficient fingerprint map management. The usefulness of the proposed methodology is presented using the actual radio fingerprint measurements taken throughout Seoul, Korea.

Comparison of Virginia's multimodal transportation corridors using cost and demographic analyses.

DOT National Transportation Integrated Search

2006-01-01

This effort was performed in support of VTrans2025, Virginia's long-range multimodal transportation plan, and the VTrans2025 Multimodal Advisory Committee. The effort develops a preliminary approach to evaluating multimodal and highway-only corridor ...

Unmanned Aerial Vehicles Master Plan, 1994. Master Plan.

DTIC Science & Technology

1994-05-31

Terminal SINCGARS = Single-Channel Ground and Airborne Radio System Figure 3-5 Maneuver Variant CONOPS I Psychological operations. deployment with early...650 KM DAT M 3 K (300 DESIRED) BEYOND FORWARD LINE OF OWN TROOPS (FLOT) APPROXIMATE RADIUS OF ACTION LEGEND ATARS = Advanced Tactical Air

Cognitive Radio will revolutionize American transportation

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

Cognitive Radio will revolutionize American transportation. Through smart technology, it will anticipate user needs; detect available bandwidths and frequencies then seamlessly connect vehicles, infrastructures, and consumer devices; and it will support the Department of Transportation IntelliDrive Program, helping researchers, auto manufacturers, and Federal and State officials advance the connectivity of US transportation systems for improved safety, mobility, and environmental conditions. Using cognitive radio, a commercial vehicle will know its driver, onboard freight and destination route. Drivers will save time and resources communicating with automatic toll booths and know ahead of time whether to stop at a weigh station or keepmore » rolling. At accident scenes, cognitive radio sensors on freight and transportation modes can alert emergency personnel and measure on-site, real-time conditions such as a chemical leak. The sensors will connect freight to industry, relaying shipment conditions and new delivery schedules. For industry or military purposes, cognitive radio will enable real-time freight tracking around the globe and its sensory technology can help prevent cargo theft or tampering by alerting shipper and receiver if freight is tampered with while en route. For the average consumer, a vehicle will tailor the transportation experience to the passenger such as delivering age-appropriate movies via satellite. Cognitive radio will enhance transportation safety by continually sensing what is important to the user adapting to its environment and incoming information, and proposing solutions that improve mobility and quality of life.« less

Results of intraoperative electron beam radiotherapy containing multimodality treatment for locally unresectable T4 rectal cancer: a pooled analysis of the Mayo Clinic Rochester and Catharina Hospital Eindhoven

PubMed Central

Holman, Fabian A.; Haddock, Michael G.; Gunderson, Leonard L.; Kusters, Miranda; Nieuwenhuijzen, Grard A. P.; van den Berg, Hetty A.; Nelson, Heidi

2016-01-01

Background The aim of this study is to analyse the pooled results of intraoperative electron beam radiotherapy (IOERT) containing multimodality treatment of locally advanced T4 rectal cancer, initially unresectable for cure, from the Mayo Clinic, Rochester, USA (MCR) and Catharina Hospital, Eindhoven, The Netherlands (CHE), both major referral centers for locally advanced rectal cancer. A rectal tumor is called locally unresectable for cure if after full clinical work-up infiltration into the surrounding structures or organs has been demonstrated, which would result in positive surgical margins if resection was the initial component of treatment. This was the reason to refer these patients to the IOERT program of one of the centers. Methods In the period from 1981 to 2010, 417 patients with locally unresectable T4 rectal carcinomas at initial presentation were treated with multimodality treatment including IOERT at either one of the two centres. The preferred treatment approach was preoperative (chemo) radiation and intended radical surgery combined with IOERT. Risk factors for local recurrence (LR), cancer specific survival, disease free survival and distant metastases (DM) were assessed. Results A total of 306 patients (73%) underwent a R0 resection. LRs and metastases occurred more frequently after an R1-2 resection (P<0.001 and P<0.001 respectively). Preoperative chemoradiation (preop CRT) was associated with a higher probability of having a R0 resection. Waiting time after preoperative treatment was inversely related with the chance of developing a LR, especially after R+ resection. In 16% of all cases a LR developed. Five-year disease free survival and overall survival (OS) were 55% and 56% respectively. Conclusions An acceptable survival can be achieved in treatment of patients with initially unresectable T4 rectal cancer with combined modality therapy that includes preop CRT and IOERT. Completeness of the resection is the most important predictive and prognostic factor in the treatment of T4 rectal cancer for all outcome parameters. IOERT can reduce the LR rate effectively, especially in R+ resected patients. PMID:28078113

Voltage-based Device Tracking in a 1.5 Tesla MRI during Imaging: Initial validation in swine models

PubMed Central

Schmidt, Ehud J; Tse, Zion TH; Reichlin, Tobias R; Michaud, Gregory F; Watkins, Ronald D; Butts-Pauly, Kim; Kwong, Raymond Y; Stevenson, William; Schweitzer, Jeffrey; Byrd, Israel; Dumoulin, Charles L

2013-01-01

Purpose Voltage-based device-tracking (VDT) systems are commonly used for tracking invasive devices in electrophysiological (EP) cardiac-arrhythmia therapy. During EP procedures, electro-anatomic-mapping (EAM) workstations provide guidance by integrating VDT location and intra-cardiac-ECG information with X-ray, CT, Ultrasound, and MR images. MR assists navigation, mapping and radio-frequency-ablation. Multi-modality interventions require multiple patient transfers between an MRI and the X-ray/ultrasound EP suite, increasing the likelihood of patient-motion and image mis-registration. An MRI-compatible VDT system may increase efficiency, since there is currently no single method to track devices both inside and outside the MRI scanner. Methods An MRI-compatible VDT system was constructed by modifying a commercial system. Hardware was added to reduce MRI gradient-ramp and radio-frequency-unblanking-pulse interference. VDT patches and cables were modified to reduce heating. Five swine cardiac VDT EAM-mapping interventions were performed, navigating inside and thereafter outside the MRI. Results Three-catheter VDT interventions were performed at >12 frames-per-second both inside and outside the MRI scanner with <3mm error. Catheters were followed on VDT- and MRI-derived maps. Simultaneous VDT and imaging was possible in repetition-time (TR) >32 msec sequences with <0.5mm errors, and <5% MRI SNR loss. At shorter TRs, only intra-cardiac-ECG was reliable. RF Heating was <1.5C°. Conclusion An MRI-compatible VDT system is feasible. PMID:23580479

Advanced approach for intraoperative MRI guidance and potential benefit for neurosurgical applications.

PubMed

Busse, Harald; Schmitgen, Arno; Trantakis, Christos; Schober, Ralf; Kahn, Thomas; Moche, Michael

2006-07-01

To present an advanced approach for intraoperative image guidance in an open 0.5 T MRI and to evaluate its effectiveness for neurosurgical interventions by comparison with a dynamic scan-guided localization technique. The built-in scan guidance mode relied on successive interactive MRI scans. The additional advanced mode provided real-time navigation based on reformatted high-quality, intraoperatively acquired MR reference data, allowed multimodal image fusion, and used the successive scans of the built-in mode for quick verification of the position only. Analysis involved tumor resections and biopsies in either scan guidance (N = 36) or advanced mode (N = 59) by the same three neurosurgeons. Technical, surgical, and workflow aspects were compared. The image quality and hand-eye coordination of the advanced approach were improved. While the average extent of resection, neurologic outcome after functional MRI (fMRI) integration, and diagnostic yield appeared to be slightly better under advanced guidance, particularly for the main surgeon, statistical analysis revealed no significant differences. Resection times were comparable, while biopsies took around 30 minutes longer. The presented approach is safe and provides more detailed images and higher navigation speed at the expense of actuality. The surgical outcome achieved with advanced guidance is (at least) as good as that obtained with dynamic scan guidance. (c) 2006 Wiley-Liss, Inc.

Radio-frequency energy harvesting for wearable sensors.

PubMed

Borges, Luís M; Chávez-Santiago, Raul; Barroca, Norberto; Velez, Fernando José; Balasingham, Ilangko

2015-02-01

The use of wearable biomedical sensors for the continuous monitoring of physiological signals will facilitate the involvement of the patients in the prevention and management of chronic diseases. The fabrication of small biomedical sensors transmitting physiological data wirelessly is possible as a result of the tremendous advances in ultra-low power electronics and radio communications. However, the widespread adoption of these devices depends very much on their ability to operate for long periods of time without the need to frequently change, recharge or even use batteries. In this context, energy harvesting (EH) is the disruptive technology that can pave the road towards the massive utilisation of wireless wearable sensors for patient self-monitoring and daily healthcare. Radio-frequency (RF) transmissions from commercial telecommunication networks represent reliable ambient energy that can be harvested as they are ubiquitous in urban and suburban areas. The state-of-the-art in RF EH for wearable biomedical sensors specifically targeting the global system of mobile 900/1800 cellular and 700 MHz digital terrestrial television networks as ambient RF energy sources are showcased. Furthermore, guidelines for the choice of the number of stages for the RF energy harvester are presented, depending on the requirements from the embedded system to power supply, which is useful for other researchers that work in the same area. The present authors' recent advances towards the development of an efficient RF energy harvester and storing system are presented and thoroughly discussed too.

Skill training in multimodal virtual environments.

PubMed

Gopher, Daniel

2012-01-01

Multimodal, immersive, virtual reality (VR) techniques open new perspectives for perceptual-motor skill trainers. They also introduce new risks and dangers. This paper describes the benefits and pitfalls of multimodal training and the cognitive building blocks of a multimodal, VR training simulators.

Superparamagnetic nanoparticles for enhanced magnetic resonance and multimodal imaging

NASA Astrophysics Data System (ADS)

Sikma, Elise Ann Schultz

Magnetic resonance imaging (MRI) is a powerful tool for noninvasive tomographic imaging of biological systems with high spatial and temporal resolution. Superparamagnetic (SPM) nanoparticles have emerged as highly effective MR contrast agents due to their biocompatibility, ease of surface modification and magnetic properties. Conventional nanoparticle contrast agents suffer from difficult synthetic reproducibility, polydisperse sizes and weak magnetism. Numerous synthetic techniques and nanoparticle formulations have been developed to overcome these barriers. However, there are still major limitations in the development of new nanoparticle-based probes for MR and multimodal imaging including low signal amplification and absence of biochemical reporters. To address these issues, a set of multimodal (T2/optical) and dual contrast (T1/T2) nanoparticle probes has been developed. Their unique magnetic properties and imaging capabilities were thoroughly explored. An enzyme-activatable contrast agent is currently being developed as an innovative means for early in vivo detection of cancer at the cellular level. Multimodal probes function by combining the strengths of multiple imaging techniques into a single agent. Co-registration of data obtained by multiple imaging modalities validates the data, enhancing its quality and reliability. A series of T2/optical probes were successfully synthesized by attachment of a fluorescent dye to the surface of different types of nanoparticles. The multimodal nanoparticles generated sufficient MR and fluorescence signal to image transplanted islets in vivo. Dual contrast T1/T2 imaging probes were designed to overcome disadvantages inherent in the individual T1 and T2 components. A class of T1/T2 agents was developed consisting of a gadolinium (III) complex (DTPA chelate or DO3A macrocycle) conjugated to a biocompatible silica-coated metal oxide nanoparticle through a disulfide linker. The disulfide linker has the ability to be reduced in vivo by glutathione, releasing large payloads of signal-enhancing T1 probes into the surrounding environment. Optimization of the agent occurred over three sequential generations, with each generation addressing a new challenge. The result was a T2 nanoparticle containing high levels of conjugated T1 complex demonstrating enhanced MR relaxation properties. The probes created here have the potential to play a key role in the advancement of nanoparticle-based agents in biomedical MRI applications.

New advanced netted ground based and topside radio diagnostics for Space Weather Program

NASA Astrophysics Data System (ADS)

Rothkaehl, Hanna; Krankowski, Andrzej; Morawski, Marek; Atamaniuk, Barbara; Zakharenkova, Irina; Cherniak, Iurii

2014-05-01

To give a more detailed and complete understanding of physical plasma processes that govern the solar-terrestrial space, and to develop qualitative and quantitative models of the magnetosphere-ionosphere-thermosphere coupling, it is necessary to design and build the next generation of instruments for space diagnostics and monitoring. Novel ground- based wide-area sensor networks, such as the LOFAR (Low Frequency Array) radar facility, comprising wide band, and vector-sensing radio receivers and multi-spacecraft plasma diagnostics should help solve outstanding problems of space physics and describe long-term environmental changes. The LOw Frequency ARray - LOFAR - is a new fully digital radio telescope designed for frequencies between 30 MHz and 240 MHz located in Europe. The three new LOFAR stations will be installed until summer 2015 in Poland. The LOFAR facilities in Poland will be distributed among three sites: Lazy (East of Krakow), Borowiec near Poznan and Baldy near Olsztyn. All they will be connected via PIONIER dedicated links to Poznan. Each site will host one LOFAR station (96 high-band+96 low-band antennas). They will most time work as a part of European network, however, when less charged, they can operate as a national network The new digital radio frequency analyzer (RFA) on board the low-orbiting RELEC satellite was designed to monitor and investigate the ionospheric plasma properties. This two-point ground-based and topside ionosphere-located space plasma diagnostic can be a useful new tool for monitoring and diagnosing turbulent plasma properties. The RFA on board the RELEC satellite is the first in a series of experiments which is planned to be launched into the near-Earth environment. In order to improve and validate the large scales and small scales ionospheric structures we will used the GPS observations collected at IGS/EPN network employed to reconstruct diurnal variations of TEC using all satellite passes over individual GPS stations and the data retrieved from FORMOSAT-3/COSMIC radio occultation measurements. The main purpose of this presentation is to describe new advanced diagnostic techniques of the near-Earth space plasma and point out the scientific challenges of the radio frequency analyser located on board of low orbiting satellites and LOFAR facilities. This research is partly supported by grant O N517 418440

Molecular basis of ‘hypoxic’ breast cancer cell radio-sensitization: phytochemicals converge on radiation induced Rel signaling

PubMed Central

2013-01-01

Background Heterogeneously distributed hypoxic areas are a characteristic property of locally advanced breast cancers (BCa) and generally associated with therapeutic resistance, metastases, and poor patient survival. About 50% of locally advanced BCa, where radiotherapy is less effective are suggested to be due to hypoxic regions. In this study, we investigated the potential of bioactive phytochemicals in radio-sensitizing hypoxic BCa cells. Methods Hypoxic (O2-2.5%; N2-92.5%; CO2-5%) MCF-7 cells were exposed to 4 Gy radiation (IR) alone or after pretreatment with Curcumin (CUR), curcumin analog EF24, neem leaf extract (NLE), Genistein (GEN), Resveratrol (RES) or raspberry extract (RSE). The cells were examined for inhibition of NFκB activity, transcriptional modulation of 88 NFκB signaling pathway genes, activation and cellular localization of radio-responsive NFκB related mediators, eNos, Erk1/2, SOD2, Akt1/2/3, p50, p65, pIκBα, TNFα, Birc-1, -2, -5 and associated induction of cell death. Results EMSA revealed that cells exposed to phytochemicals showed complete suppression of IR-induced NFκB. Relatively, cells exposed EF24 revealed a robust inhibition of IR-induced NFκB. QPCR profiling showed induced expression of 53 NFκB signaling pathway genes after IR. Conversely, 53, 50, 53, 53, 53 and 53 of IR-induced genes were inhibited with EF24, NLE, CUR, GEN, RES and RSE respectively. In addition, 25, 29, 24, 16, 11 and 21 of 35 IR-suppressed genes were further inhibited with EF24, NLE, CUR, GEN, RES and RSE respectively. Immunoblotting revealed a significant attenuating effect of IR-modulated radio-responsive eNos, Erk1/2, SOD2, Akt1/2/3, p50, p65, pIκBα, TNFα, Birc-1, -2 and −5 with EF24, NLE, CUR, GEN, RES or RSE. Annexin V-FITC staining showed a consistent and significant induction of IR-induced cell death with these phytochemicals. Notably, EF24 robustly conferred IR-induced cell death. Conclusions Together, these data identifies the potential hypoxic cell radio-sensitizers and further implies that the induced radio-sensitization may be exerted by selectively targeting IR-induced NFκB signaling. PMID:23452621

The Study on the Optimization of Container Multimodal Transport Business Process in Shandong

NASA Astrophysics Data System (ADS)

Wang, Fengmei; Gong, Xiaoyi; Ni, Yingying; Zhan, Jun; Che, Huiping

2018-06-01

Shandong is a coastal city with good location advantages. As a hub port for international trade goods and a port of transhipment, shandong's demand for multimodal transport is more urgent. By selecting the suitable non-water port and the multimodal transport carrier to improve the efficiency of multimodal transport, the purpose of saving the time of logistics is achieved, thus reducing the logistics cost.It branch out through Shandongt, and it can reach the central region of China, can reach the Western remote area ,too. This paper puts forward the optimization scheme of the business process of container multimodal transport. The optimization of freight forwarding business process is analyzed. The multimodal transport model in Shandong was designed. Finally, the optimal approach of multimodal transport in Shandong is put forward.

Construction of Multimodal Transport Information Platform

NASA Astrophysics Data System (ADS)

Wang, Ya; Cheng, Yu; Zhao, Zhi

2018-06-01

With the rapid development of economy, the volume of transportation in China is increasing, the opening process of the market is accelerating, the scale of enterprises is expanding, the service quality is being improved, and the container multimodal transport is developing continuously.The hardware infrastructure of container multimodal transport is improved obviously, but the network platform construction of multimodal transport is still insufficient.Taking Shandong region of China as an example, the present situation of container multimodal transport in Shandong area can no longer meet the requirement of rapid development of container, and the construction of network platform needs to be solved urgently. Therefore, this paper will briefly describe the conception of construction of multimodal transport network platform in Shandong area.In order to achieve the rapid development of multimodal transport.

Lessons Learned from Six Decades of Radio Polarimetry

NASA Astrophysics Data System (ADS)

Wiesemeyer, Helmut; Güsten, R.; Kreysa, E.; Menten, K. M.; Morris, D.; Paubert, G.; Pillai, T.; Sievers, A.; Thum, C.

2018-01-01

The characterization of polarized emission from continuum radiation and spectral lines across large-scale galactic and extragalactic fields is a typical application of single-dish telescopes, from radio to far-infrared wavelengths. Despite its high analytical value, in many cases polarimetry was added to the design specifications of telescopes and their frontends only in advanced development stages. While in some situations the instrumental contamination of the Stokes parameters can be corrected, this becomes increasingly difficult for extended fields. This contribution summarizes the current situation at mm/submm telescopes. Strategies for post-observing polarization calibration are presented as well as methods to optimize the components in the beam path.

Advanced mathematics communication beyond modality of\\xA0sight

NASA Astrophysics Data System (ADS)

Sedaghatjou, Mina

2018-01-01

This study illustrates how mathematical communication and learning are inherently multimodal and embodied; hence, sight-disabled students are also able to conceptualize visuospatial information and mathematical concepts through tactile and auditory activities. Adapting a perceptuomotor integration approach, the study shows that the lack of access to visual fields in an advanced mathematics course does not obstruct a blind student's ability to visualize, but transforms it. The goal of this study is not to compare the visually impaired student with non-visually impaired students to address the 'differences' in understanding; instead, I discuss the challenges that a blind student, named Anthony, has encountered and the ways that we tackled those problems. I also demonstrate how the proper and precisely crafted tactile materials empowered Anthony to learn mathematical functions.

Advanced Endoscopic Navigation: Surgical Big Data, Methodology, and Applications.

PubMed

Luo, Xiongbiao; Mori, Kensaku; Peters, Terry M

2018-06-04

Interventional endoscopy (e.g., bronchoscopy, colonoscopy, laparoscopy, cystoscopy) is a widely performed procedure that involves either diagnosis of suspicious lesions or guidance for minimally invasive surgery in a variety of organs within the body cavity. Endoscopy may also be used to guide the introduction of certain items (e.g., stents) into the body. Endoscopic navigation systems seek to integrate big data with multimodal information (e.g., computed tomography, magnetic resonance images, endoscopic video sequences, ultrasound images, external trackers) relative to the patient's anatomy, control the movement of medical endoscopes and surgical tools, and guide the surgeon's actions during endoscopic interventions. Nevertheless, it remains challenging to realize the next generation of context-aware navigated endoscopy. This review presents a broad survey of various aspects of endoscopic navigation, particularly with respect to the development of endoscopic navigation techniques. First, we investigate big data with multimodal information involved in endoscopic navigation. Next, we focus on numerous methodologies used for endoscopic navigation. We then review different endoscopic procedures in clinical applications. Finally, we discuss novel techniques and promising directions for the development of endoscopic navigation.

User-based representation of time-resolved multimodal public transportation networks.

PubMed

Alessandretti, Laura; Karsai, Márton; Gauvin, Laetitia

2016-07-01

Multimodal transportation systems, with several coexisting services like bus, tram and metro, can be represented as time-resolved multilayer networks where the different transportation modes connecting the same set of nodes are associated with distinct network layers. Their quantitative description became possible recently due to openly accessible datasets describing the geo-localized transportation dynamics of large urban areas. Advancements call for novel analytics, which combines earlier established methods and exploits the inherent complexity of the data. Here, we provide a novel user-based representation of public transportation systems, which combines representations, accounting for the presence of multiple lines and reducing the effect of spatial embeddedness, while considering the total travel time, its variability across the schedule, and taking into account the number of transfers necessary. After the adjustment of earlier techniques to the novel representation framework, we analyse the public transportation systems of several French municipal areas and identify hidden patterns of privileged connections. Furthermore, we study their efficiency as compared to the commuting flow. The proposed representation could help to enhance resilience of local transportation systems to provide better design policies for future developments.

Multiscale CNNs for Brain Tumor Segmentation and Diagnosis.

PubMed

Zhao, Liya; Jia, Kebin

2016-01-01

Early brain tumor detection and diagnosis are critical to clinics. Thus segmentation of focused tumor area needs to be accurate, efficient, and robust. In this paper, we propose an automatic brain tumor segmentation method based on Convolutional Neural Networks (CNNs). Traditional CNNs focus only on local features and ignore global region features, which are both important for pixel classification and recognition. Besides, brain tumor can appear in any place of the brain and be any size and shape in patients. We design a three-stream framework named as multiscale CNNs which could automatically detect the optimum top-three scales of the image sizes and combine information from different scales of the regions around that pixel. Datasets provided by Multimodal Brain Tumor Image Segmentation Benchmark (BRATS) organized by MICCAI 2013 are utilized for both training and testing. The designed multiscale CNNs framework also combines multimodal features from T1, T1-enhanced, T2, and FLAIR MRI images. By comparison with traditional CNNs and the best two methods in BRATS 2012 and 2013, our framework shows advances in brain tumor segmentation accuracy and robustness.

User-based representation of time-resolved multimodal public transportation networks

PubMed Central

Alessandretti, Laura; Gauvin, Laetitia

2016-01-01

Multimodal transportation systems, with several coexisting services like bus, tram and metro, can be represented as time-resolved multilayer networks where the different transportation modes connecting the same set of nodes are associated with distinct network layers. Their quantitative description became possible recently due to openly accessible datasets describing the geo-localized transportation dynamics of large urban areas. Advancements call for novel analytics, which combines earlier established methods and exploits the inherent complexity of the data. Here, we provide a novel user-based representation of public transportation systems, which combines representations, accounting for the presence of multiple lines and reducing the effect of spatial embeddedness, while considering the total travel time, its variability across the schedule, and taking into account the number of transfers necessary. After the adjustment of earlier techniques to the novel representation framework, we analyse the public transportation systems of several French municipal areas and identify hidden patterns of privileged connections. Furthermore, we study their efficiency as compared to the commuting flow. The proposed representation could help to enhance resilience of local transportation systems to provide better design policies for future developments. PMID:27493773

An open resource for transdiagnostic research in pediatric mental health and learning disorders

PubMed Central

Alexander, Lindsay M.; Escalera, Jasmine; Ai, Lei; Andreotti, Charissa; Febre, Karina; Mangone, Alexander; Vega-Potler, Natan; Langer, Nicolas; Alexander, Alexis; Kovacs, Meagan; Litke, Shannon; O'Hagan, Bridget; Andersen, Jennifer; Bronstein, Batya; Bui, Anastasia; Bushey, Marijayne; Butler, Henry; Castagna, Victoria; Camacho, Nicolas; Chan, Elisha; Citera, Danielle; Clucas, Jon; Cohen, Samantha; Dufek, Sarah; Eaves, Megan; Fradera, Brian; Gardner, Judith; Grant-Villegas, Natalie; Green, Gabriella; Gregory, Camille; Hart, Emily; Harris, Shana; Horton, Megan; Kahn, Danielle; Kabotyanski, Katherine; Karmel, Bernard; Kelly, Simon P.; Kleinman, Kayla; Koo, Bonhwang; Kramer, Eliza; Lennon, Elizabeth; Lord, Catherine; Mantello, Ginny; Margolis, Amy; Merikangas, Kathleen R.; Milham, Judith; Minniti, Giuseppe; Neuhaus, Rebecca; Levine, Alexandra; Osman, Yael; Parra, Lucas C.; Pugh, Ken R.; Racanello, Amy; Restrepo, Anita; Saltzman, Tian; Septimus, Batya; Tobe, Russell; Waltz, Rachel; Williams, Anna; Yeo, Anna; Castellanos, Francisco X.; Klein, Arno; Paus, Tomas; Leventhal, Bennett L.; Craddock, R. Cameron; Koplewicz, Harold S.; Milham, Michael P.

2017-01-01

Technological and methodological innovations are equipping researchers with unprecedented capabilities for detecting and characterizing pathologic processes in the developing human brain. As a result, ambitions to achieve clinically useful tools to assist in the diagnosis and management of mental health and learning disorders are gaining momentum. To this end, it is critical to accrue large-scale multimodal datasets that capture a broad range of commonly encountered clinical psychopathology. The Child Mind Institute has launched the Healthy Brain Network (HBN), an ongoing initiative focused on creating and sharing a biobank of data from 10,000 New York area participants (ages 5–21). The HBN Biobank houses data about psychiatric, behavioral, cognitive, and lifestyle phenotypes, as well as multimodal brain imaging (resting and naturalistic viewing fMRI, diffusion MRI, morphometric MRI), electroencephalography, eye-tracking, voice and video recordings, genetics and actigraphy. Here, we present the rationale, design and implementation of HBN protocols. We describe the first data release (n=664) and the potential of the biobank to advance related areas (e.g., biophysical modeling, voice analysis). PMID:29257126

Multi-modality molecular imaging: pre-clinical laboratory configuration

NASA Astrophysics Data System (ADS)

Wu, Yanjun; Wellen, Jeremy W.; Sarkar, Susanta K.

2006-02-01

In recent years, the prevalence of in vivo molecular imaging applications has rapidly increased. Here we report on the construction of a multi-modality imaging facility in a pharmaceutical setting that is expected to further advance existing capabilities for in vivo imaging of drug distribution and the interaction with their target. The imaging instrumentation in our facility includes a microPET scanner, a four wavelength time-domain optical imaging scanner, a 9.4T/30cm MRI scanner and a SPECT/X-ray CT scanner. An electronics shop and a computer room dedicated to image analysis are additional features of the facility. The layout of the facility was designed with a central animal preparation room surrounded by separate laboratory rooms for each of the major imaging modalities to accommodate the work-flow of simultaneous in vivo imaging experiments. This report will focus on the design of and anticipated applications for our microPET and optical imaging laboratory spaces. Additionally, we will discuss efforts to maximize the daily throughput of animal scans through development of efficient experimental work-flows and the use of multiple animals in a single scanning session.

Multimodal Imaging in Diabetic Macular Edema.

PubMed

Acón, Dhariana; Wu, Lihteh

2018-01-01

Throughout ophthalmic history it has been shown that progress has gone hand in hand with technological breakthroughs. In the past, fluorescein angiography and fundus photographs were the most commonly used imaging modalities in the management of diabetic macular edema (DME). Today, despite the moderate correlation between macular thickness and functional outcomes, spectral domain optical coherence tomography (SD-OCT) has become the DME workhorse in clinical practice. Several SD-OCT biomarkers have been looked at including presence of epiretinal membrane, vitreomacular adhesion, disorganization of the inner retinal layers, central macular thickness, integrity of the ellipsoid layer, and subretinal fluid, among others. Emerging imaging modalities include fundus autofluorescence, macular pigment optical density, fluorescence lifetime imaging ophthalmoscopy, OCT angiography, and adaptive optics. Technological advances in imaging of the posterior segment of the eye have enabled ophthalmologists to develop hypotheses about pathological mechanisms of disease, monitor disease progression, and assess response to treatment. Spectral domain OCT is the most commonly performed imaging modality in the management of DME. However, reliable biomarkers have yet to be identified. Machine learning may provide treatment algorithms based on multimodal imaging. Copyright 2018 Asia-Pacific Academy of Ophthalmology.

Use of multidimensional, multimodal imaging and PACS to support neurological diagnoses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wong, S.T.C.; Knowlton, R.; Hoo, K.S.

1995-12-31

Technological advances in brain imaging have revolutionized diagnosis in neurology and neurological surgery. Major imaging techniques include magnetic resonance imaging (MRI) to visualize structural anatomy, positron emission tomography (PET) to image metabolic function and cerebral blood flow, magnetoencephalography (MEG) to visualize the location of physiologic current sources, and magnetic resonance spectroscopy (MRS) to measure specific biochemicals. Each of these techniques studies different biomedical aspects of the grain, but there lacks an effective means to quantify and correlate the disparate imaging datasets in order to improve clinical decision making processes. This paper describes several techniques developed in a UNIX-based neurodiagnostic workstationmore » to aid the non-invasive presurgical evaluation of epilepsy patients. These techniques include on-line access to the picture archiving and communication systems (PACS) multimedia archive, coregistration of multimodality image datasets, and correlation and quantitative of structural and functional information contained in the registered images. For illustration, the authors describe the use of these techniques in a patient case of non-lesional neocortical epilepsy. They also present the future work based on preliminary studies.« less

Current status of predictive biomarkers for neoadjuvant therapy in esophageal cancer

PubMed Central

Uemura, Norihisa; Kondo, Tadashi

2014-01-01

Neoadjuvant therapy has been proven to be extremely valuable and is widely used for advanced esophageal cancer. However, a significant proportion of treated patients (60%-70%) does not respond well to neoadjuvant treatments and develop severe adverse effects. Therefore, predictive markers for individualization of multimodality treatments are urgently needed in esophageal cancer. Recently, molecular biomarkers that predict the response to neoadjuvant therapy have been explored in multimodal approaches in esophageal cancer and successful examples of biomarker identification have been reported. In this review, promising candidates for predictive molecular biomarkers developed by using multiple molecular approaches are reviewed. Moreover, treatment strategies based on the status of predicted biomarkers are discussed, while considering the international differences in the clinical background. However, in the absence of adequate treatment options related to the results of the biomarker test, the usefulness of these diagnostic tools is limited and new effective therapies for biomarker-identified nonresponders to cancer treatment should be concurrent with the progress of predictive technologies. Further improvement in the prognosis of esophageal cancer patients can be achieved through the introduction of novel therapeutic approaches in clinical practice. PMID:25133032

[Radiofrequency ablation in the multimodal treatment of liver metastases--preliminary report].

PubMed

Burcoveanu, C; Dogaru, C; Diaconu, C; Grecu, F; Dragomir, Cr; Pricop, Adriana; Balan, G; Drug, V L

2007-01-01

Although the "gold standard" in the multimodal treatment of liver primary and secondary tumors is the surgical ablation, the rate of resection, despite the last decades advances, remains still low (10 - 20%). In addition, the interest for non-surgical ablation therapies is increasing. Among them, regional or systemic chemotherapy, intra-arterial radiotherapy as well as locally targeted therapies--cryotherapy, alcohol instillation and radiofrequency (RF) are the most valuable options as alternative to the surgical approach. Between February 2005 - January 2007, 9 patients with liver metastases underwent open RF ablation of their secondaries in the III-rd Surgical Unit, "St. Spiridon" Hospital. An Elektrotom 106 HiTT Berchtold device with a 60W power generator and a 15 mm monopolar active electrode was used. Destruction of the tumors was certified with intraoperative ultrasound examination. Pre- and postoperative CarcinoEmbryonic Antigen (CEA) together with imaging follow-up was carried out, in order to determine local or systemic recurrencies. Six patients died between 6 month - 4 years after the RF ablation. Median survival is 29.2 months. RF ablation is a challenge alternative in non-resectable liver tumors.

Applications of the Petri net to simulate, test, and validate the performance and safety of complex, heterogeneous, multi-modality patient monitoring alarm systems.

PubMed

Sloane, E B; Gelhot, V

2004-01-01

This research is motivated by the rapid pace of medical device and information system integration. Although the ability to interconnect many medical devices and information systems may help improve patient care, there is no way to detect if incompatibilities between one or more devices might cause critical events such as patient alarms to go unnoticed or cause one or more of the devices to become stuck in a disabled state. Petri net tools allow automated testing of all possible states and transitions between devices and/or systems to detect potential failure modes in advance. This paper describes an early research project to use Petri nets to simulate and validate a multi-modality central patient monitoring system. A free Petri net tool, HPSim, is used to simulate two wireless patient monitoring networks: one with 44 heart monitors and a central monitoring system and a second version that includes an additional 44 wireless pulse oximeters. In the latter Petri net simulation, a potentially dangerous heart arrhythmia and pulse oximetry alarms were detected.

"Filming in Progress": New Spaces for Multimodal Designing

ERIC Educational Resources Information Center

Mills, Kathy A.

2010-01-01

Global trends call for new research to investigate multimodal designing mediated by new technologies and the implications for classroom spaces. This article addresses the relationship between new technologies, students' multimodal designing, and the social production of classroom spaces. Multimodal semiotics and sociological principles are applied…

Advanced Teleprocessing Systems

DTIC Science & Technology

1980-03-31

75 Gitman , I., "On the Capacity of Slotted ALOHA Networks and Some Design Problems," IEEE Transactions on Communications, Vol. COM-23, March 1975, pp...305-317. GITM 76 Gitman , I., R. Van Slyke and H. Frank, "Routing in Packet-Switching Broadcast Radio Networks," IEEE Transactions on Communications

Adaptive multimodal interaction in mobile augmented reality: A conceptual framework

NASA Astrophysics Data System (ADS)

Abidin, Rimaniza Zainal; Arshad, Haslina; Shukri, Saidatul A'isyah Ahmad

2017-10-01

Recently, Augmented Reality (AR) is an emerging technology in many mobile applications. Mobile AR was defined as a medium for displaying information merged with the real world environment mapped with augmented reality surrounding in a single view. There are four main types of mobile augmented reality interfaces and one of them are multimodal interfaces. Multimodal interface processes two or more combined user input modes (such as speech, pen, touch, manual gesture, gaze, and head and body movements) in a coordinated manner with multimedia system output. In multimodal interface, many frameworks have been proposed to guide the designer to develop a multimodal applications including in augmented reality environment but there has been little work reviewing the framework of adaptive multimodal interface in mobile augmented reality. The main goal of this study is to propose a conceptual framework to illustrate the adaptive multimodal interface in mobile augmented reality. We reviewed several frameworks that have been proposed in the field of multimodal interfaces, adaptive interface and augmented reality. We analyzed the components in the previous frameworks and measure which can be applied in mobile devices. Our framework can be used as a guide for designers and developer to develop a mobile AR application with an adaptive multimodal interfaces.

Analyzing a multimodal biometric system using real and virtual users

NASA Astrophysics Data System (ADS)

Scheidat, Tobias; Vielhauer, Claus

2007-02-01

Three main topics of recent research on multimodal biometric systems are addressed in this article: The lack of sufficiently large multimodal test data sets, the influence of cultural aspects and data protection issues of multimodal biometric data. In this contribution, different possibilities are presented to extend multimodal databases by generating so-called virtual users, which are created by combining single biometric modality data of different users. Comparative tests on databases containing real and virtual users based on a multimodal system using handwriting and speech are presented, to study to which degree the use of virtual multimodal databases allows conclusions with respect to recognition accuracy in comparison to real multimodal data. All tests have been carried out on databases created from donations from three different nationality groups. This allows to review the experimental results both in general and in context of cultural origin. The results show that in most cases the usage of virtual persons leads to lower accuracy than the usage of real users in terms of the measurement applied: the Equal Error Rate. Finally, this article will address the general question how the concept of virtual users may influence the data protection requirements for multimodal evaluation databases in the future.

Experiences of Australian men diagnosed with advanced prostate cancer: a qualitative study

PubMed Central

Chambers, Suzanne K; Hyde, Melissa K; Laurie, Kirstyn; Legg, Melissa; Frydenberg, Mark; Davis, Ian D; Lowe, Anthony; Dunn, Jeff

2018-01-01

Objective To explore men’s lived experience of advanced prostate cancer (PCa) and preferences for support. Design Cross-sectional qualitative study applying open-ended surveys and interviews conducted between June and November 2016. Interviews audio-recorded and transcribed verbatim and analysed from an interpretive phenomenological perspective. Setting Australia, nation-wide. Participants 39 men diagnosed with advanced PCa (metastatic or castration-resistant biochemical progression) were surveyed with 28 men subsequently completing a semistructured in depth telephone interview. Results Thematic analysis of interviews identified two organising themes: lived experience and supportive care. Lived experience included six superordinate themes: regret about late diagnosis and treatment decisions, being discounted in the health system, fear/uncertainty about the future, acceptance of their situation, masculinity and treatment effects. Supportive care included five superordinate themes: communication, care coordination, accessible care, shared experience/peer support and involvement of their partner/family. Conclusions Life course and the health and social context of PCa influence men’s experiences of advanced disease. Multimodal interventions integrating peer support and specialist nurses are needed that more closely articulate with men’s expressed needs. PMID:29455168

Multimodal Career Education for Nursing Students.

ERIC Educational Resources Information Center

Southern, Stephen; Smith, Robert L.

A multimodal career education model entitled BEST IDEA was field tested as an approach to the problem of retaining skilled nurses in the work force. Using multimodal assessment and intervention strategies derived from the multimodal behavior therapy of Arnold Lazarus, researchers developed an individualized career development assessment and…

Locating the Semiotic Power of Multimodality

ERIC Educational Resources Information Center

Hull, Glynda A.; Nelson, Mark Evan

2005-01-01

This article reports research that attempts to characterize what is powerful about digital multimodal texts. Building from recent theoretical work on understanding the workings and implications of multimodal communication, the authors call for a continuing empirical investigation into the roles that digital multimodal texts play in real-world…

One-stop-shop stroke imaging with functional CT.

PubMed

Tong, Elizabeth; Komlosi, Peter; Wintermark, Max

2015-12-01

Advanced imaging techniques have extended beyond traditional anatomic imaging and progressed to dynamic, physiologic and functional imaging. Neuroimaging is no longer a mere diagnostic tool. Multimodal functional CT, comprising of NCCT, PCT and CTA, provides a one-stop-shop for rapid stroke imaging. Integrating those imaging findings with pertinent clinical information can help guide subsequent treatment decisions, medical management and follow-up imaging selection. This review article will briefly discuss the indication and utility of each modality in acute stroke imaging. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Review of cardiovascular imaging in The Journal of Nuclear Cardiology in 2014: Part 1 of 2: Positron emission tomography, computed tomography, and neuronal imaging.

PubMed

AlJaroudi, Wael A; Hage, Fadi G

2015-06-01

The year 2014 has been an exciting year for the cardiovascular imaging community with significant advances in the realm of nuclear and multimodality cardiac imaging. In this new feature of the Journal of Nuclear Cardiology, we will summarize some of the breakthroughs that were published in the Journal in 2014 in 2 sister articles. This first article will concentrate on publications dealing with cardiac positron emission tomography (PET), computed tomography (CT), and neuronal imaging.

Controlling upconversion nanocrystals for emerging applications

NASA Astrophysics Data System (ADS)

Zhou, Bo; Shi, Bingyang; Jin, Dayong; Liu, Xiaogang

2015-11-01

Lanthanide-doped upconversion nanocrystals enable anti-Stokes emission with pump intensities several orders of magnitude lower than required by conventional nonlinear optical techniques. Their exceptional properties, namely large anti-Stokes shifts, sharp emission spectra and long excited-state lifetimes, have led to a diversity of applications. Here, we review upconversion nanocrystals from the perspective of fundamental concepts and examine the technical challenges in relation to emission colour tuning and luminescence enhancement. In particular, we highlight the advances in functionalization strategies that enable the broad utility of upconversion nanocrystals for multimodal imaging, cancer therapy, volumetric displays and photonics.

Multidisciplinary Treatment of Head and Neck Cancer

PubMed Central

Varkey, Prashanth; Liu, Yi-Tien; Tan, Ngian Chye

2010-01-01

Head and neck cancer remains a significant cause of morbidity worldwide. Multimodality treatment is often the only way to achieve improved function, quality of life, and survival, calling for a multidisciplinary team approach, particularly in view of the rapid advances being made in various fields. The roles of the head and neck surgeon and reconstructive surgeon are discussed, together with the input afforded by specialists in areas such as diagnostic imaging, radiation therapy, medical oncology, and gene therapy. Telemedicine is of importance in centers where multidisciplinary expertise is not available. PMID:22550455

A multimodal parallel architecture: A cognitive framework for multimodal interactions.

PubMed

Cohn, Neil

2016-01-01

Human communication is naturally multimodal, and substantial focus has examined the semantic correspondences in speech-gesture and text-image relationships. However, visual narratives, like those in comics, provide an interesting challenge to multimodal communication because the words and/or images can guide the overall meaning, and both modalities can appear in complicated "grammatical" sequences: sentences use a syntactic structure and sequential images use a narrative structure. These dual structures create complexity beyond those typically addressed by theories of multimodality where only a single form uses combinatorial structure, and also poses challenges for models of the linguistic system that focus on single modalities. This paper outlines a broad theoretical framework for multimodal interactions by expanding on Jackendoff's (2002) parallel architecture for language. Multimodal interactions are characterized in terms of their component cognitive structures: whether a particular modality (verbal, bodily, visual) is present, whether it uses a grammatical structure (syntax, narrative), and whether it "dominates" the semantics of the overall expression. Altogether, this approach integrates multimodal interactions into an existing framework of language and cognition, and characterizes interactions between varying complexity in the verbal, bodily, and graphic domains. The resulting theoretical model presents an expanded consideration of the boundaries of the "linguistic" system and its involvement in multimodal interactions, with a framework that can benefit research on corpus analyses, experimentation, and the educational benefits of multimodality. Copyright © 2015.

Multimodal fusion of brain imaging data: A key to finding the missing link(s) in complex mental illness

PubMed Central

Calhoun, Vince D; Sui, Jing

2016-01-01

It is becoming increasingly clear that combining multi-modal brain imaging data is able to provide more information for individual subjects by exploiting the rich multimodal information that exists. However, the number of studies that do true multimodal fusion (i.e. capitalizing on joint information among modalities) is still remarkably small given the known benefits. In part, this is because multi-modal studies require broader expertise in collecting, analyzing, and interpreting the results than do unimodal studies. In this paper, we start by introducing the basic reasons why multimodal data fusion is important and what it can do, and importantly how it can help us avoid wrong conclusions and help compensate for imperfect brain imaging studies. We also discuss the challenges that need to be confronted for such approaches to be more widely applied by the community. We then provide a review of the diverse studies that have used multimodal data fusion (primarily focused on psychosis) as well as provide an introduction to some of the existing analytic approaches. Finally, we discuss some up-and-coming approaches to multi-modal fusion including deep learning and multimodal classification which show considerable promise. Our conclusion is that multimodal data fusion is rapidly growing, but it is still underutilized. The complexity of the human brain coupled with the incomplete measurement provided by existing imaging technology makes multimodal fusion essential in order to mitigate against misdirection and hopefully provide a key to finding the missing link(s) in complex mental illness. PMID:27347565

Multimodal fusion of brain imaging data: A key to finding the missing link(s) in complex mental illness.

PubMed

Calhoun, Vince D; Sui, Jing

2016-05-01

It is becoming increasingly clear that combining multi-modal brain imaging data is able to provide more information for individual subjects by exploiting the rich multimodal information that exists. However, the number of studies that do true multimodal fusion (i.e. capitalizing on joint information among modalities) is still remarkably small given the known benefits. In part, this is because multi-modal studies require broader expertise in collecting, analyzing, and interpreting the results than do unimodal studies. In this paper, we start by introducing the basic reasons why multimodal data fusion is important and what it can do, and importantly how it can help us avoid wrong conclusions and help compensate for imperfect brain imaging studies. We also discuss the challenges that need to be confronted for such approaches to be more widely applied by the community. We then provide a review of the diverse studies that have used multimodal data fusion (primarily focused on psychosis) as well as provide an introduction to some of the existing analytic approaches. Finally, we discuss some up-and-coming approaches to multi-modal fusion including deep learning and multimodal classification which show considerable promise. Our conclusion is that multimodal data fusion is rapidly growing, but it is still underutilized. The complexity of the human brain coupled with the incomplete measurement provided by existing imaging technology makes multimodal fusion essential in order to mitigate against misdirection and hopefully provide a key to finding the missing link(s) in complex mental illness.

Multimodal Discourse Analysis of the Movie "Argo"

ERIC Educational Resources Information Center

Bo, Xu

2018-01-01

Based on multimodal discourse theory, this paper makes a multimodal discourse analysis of some shots in the movie "Argo" from the perspective of context of culture, context of situation and meaning of image. Results show that this movie constructs multimodal discourse through particular context, language and image, and successfully…

The Work of Comics Collaborations: Considerations of Multimodal Composition for Writing Scholarship and Pedagogy

ERIC Educational Resources Information Center

Scanlon, Molly J.

2015-01-01

Though multimodality is increasingly incorporated into our pedagogies and scholarship, explorations of collaborative multimodal composition are lacking. Existing literature on collaborative writing focuses predominately on texts either composed in singular modes or by a single author, neglecting the ways in which multimodal texts are composed…

How Multimodality Works in Mathematical Activity: Young Children Graphing Motion

ERIC Educational Resources Information Center

Ferrara, Francesca

2014-01-01

This paper aims to contribute to discussions on the multimodal nature of cognition through an elaboration of the ways multimodal aspects of thinking are exploited by learners doing mathematics. Moving beyond the fact "that" multimodality occurs, this paper focuses on "how" it occurs, with particular attention drawn to the…

Designing Multimodal Texts about the Middle Ages

ERIC Educational Resources Information Center

Insulander, Eva; Lindstrand, Fredrik; Selander, Staffan

2017-01-01

Multimedial and multimodal communication arouse interest in many fields of research today. By contrast, little attention is paid to multimodality in relation to designs for learning, especially in relation to representations of knowledge on an aggregated level. By analyzing three multimodal texts about the Middle Ages, including a textbook, a film…

An ultrawide-bandwidth single-sideband modulator for terahertz frequencies

NASA Astrophysics Data System (ADS)

Meijer, A. S.; Berden, G.; Arslanov, D. D.; Ozerov, M.; Jongma, R. T.; van der Zande, W. J.

2016-11-01

Wireless high-speed data communication using terahertz (THz) carrier frequencies is becoming reality with data rates beyond 100 Gbit s-1. Many of the mobile applications use internet access and require that THz wireless base stations are connected to a global network, such as the radio-over-fibre network. We present the realization of an ultrawide bandwidth THz optical single-sideband (OSSB) modulator for converting (free-space) THz signals to THz optical modulations with an increased spectral efficiency. THz OSSB will mitigate chromatic dispersion-induced propagation losses in optical fibres and support digital modulation schemes. We demonstrate THz OSSB for free-space radiation between 0.3 and 1.0 THz using a specially designed dichroic beamsplitter for signal and carrier, and a planar light-wave circuit with multimode interference structures. This arrangement of optical elements mimics the Hartley single-sideband modulator for electronics signals and accomplishes the required Hilbert transform without any frequency-dependent tuning element over an ultrawide THz spectrum.

Photonically enabled Ka-band radar and infrared sensor subscale testbed

NASA Astrophysics Data System (ADS)

Lohr, Michele B.; Sova, Raymond M.; Funk, Kevin B.; Airola, Marc B.; Dennis, Michael L.; Pavek, Richard E.; Hollenbeck, Jennifer S.; Garrison, Sean K.; Conard, Steven J.; Terry, David H.

2014-10-01

A subscale radio frequency (RF) and infrared (IR) testbed using novel RF-photonics techniques for generating radar waveforms is currently under development at The Johns Hopkins University Applied Physics Laboratory (JHU/APL) to study target scenarios in a laboratory setting. The linearity of Maxwell's equations allows the use of millimeter wavelengths and scaled-down target models to emulate full-scale RF scene effects. Coupled with passive IR and visible sensors, target motions and heating, and a processing and algorithm development environment, this testbed provides a means to flexibly and cost-effectively generate and analyze multi-modal data for a variety of applications, including verification of digital model hypotheses, investigation of correlated phenomenology, and aiding system capabilities assessment. In this work, concept feasibility is demonstrated for simultaneous RF, IR, and visible sensor measurements of heated, precessing, conical targets and of a calibration cylinder. Initial proof-of-principle results are shown of the Ka-band subscale radar, which models S-band for 1/10th scale targets, using stretch processing and Xpatch models.

Para-hydrogen raser delivers sub-millihertz resolution in nuclear magnetic resonance

NASA Astrophysics Data System (ADS)

Suefke, Martin; Lehmkuhl, Sören; Liebisch, Alexander; Blümich, Bernhard; Appelt, Stephan

2017-06-01

The precision of nuclear magnetic resonance spectroscopy (NMR) is limited by the signal-to-noise ratio, the measurement time Tm and the linewidth Δν = 1/(πT2). Overcoming the T 2 limit is possible if the nuclear spins of a molecule emit continuous radio waves. Lasers and masers are self-organized systems which emit coherent radiation in the optical and micro-wave regime. Both are based on creating a population inversion of specific energy states. Here we show continuous oscillations of proton spins of organic molecules in the radiofrequency regime (raser). We achieve this by coupling a population inversion created through signal amplification by reversible exchange (SABRE) to a high-quality-factor resonator. For the case of 15N labelled molecules, we observe multi-mode raser activity, which reports different spin quantum states. The corresponding 1H-15N J-coupled NMR spectra exhibit unprecedented sub-millihertz resolution and can be explained assuming two-spin ordered quantum states. Our findings demonstrate a substantial improvement in the frequency resolution of NMR.

Repurposing Drugs in Oncology (ReDO)—diclofenac as an anti-cancer agent

PubMed Central

Pantziarka, Pan; Sukhatme, Vidula; Bouche, Gauthier; Meheus, Lydie; Sukhatme, Vikas P

2016-01-01

Diclofenac (DCF) is a well-known and widely used non-steroidal anti-inflammatory drug (NSAID), with a range of actions which are of interest in an oncological context. While there has long been an interest in the use of NSAIDs in chemoprevention, there is now emerging evidence that such drugs may have activity in a treatment setting. DCF, which is a potent inhibitor of COX-2 and prostaglandin E2 synthesis, displays a range of effects on the immune system, the angiogenic cascade, chemo- and radio-sensitivity and tumour metabolism. Both pre-clinical and clinical evidence of these effects, in multiple cancer types, is assessed and summarised and relevant mechanisms of action outlined. Based on this evidence the case is made for further clinical investigation of the anticancer effects of DCF, particularly in combination with other agents - with a range of possible multi-drug and multi-modality combinations outlined in the supplementary materials accompanying the main paper. PMID:26823679

GLOBECOM '86 - Global Telecommunications Conference, Houston, TX, Dec. 1-4, 1986, Conference Record. Volumes 1, 2, & 3

NASA Astrophysics Data System (ADS)

Papers are presented on local area networks; formal methods for communication protocols; computer simulation of communication systems; spread spectrum and coded communications; tropical radio propagation; VLSI for communications; strategies for increasing software productivity; multiple access communications; advanced communication satellite technologies; and spread spectrum systems. Topics discussed include Space Station communication and tracking development and design; transmission networks; modulation; data communications; computer network protocols and performance; and coding and synchronization. Consideration is given to free space optical communications systems; VSAT communication networks; network topology design; advances in adaptive filtering echo cancellation and adaptive equalization; advanced signal processing for satellite communications; the elements, design, and analysis of fiber-optic networks; and advances in digital microwave systems.

33 CFR 117.815 - Westchester Creek.

Code of Federal Regulations, 2010 CFR

2010-07-01

... DRAWBRIDGE OPERATION REGULATIONS Specific Requirements New York § 117.815 Westchester Creek. The draw of the Bruckner Boulevard/Unionport Bridge, mile 1.7, at the Bronx, New York, shall open on signal if at least a two-hour advance notice is given to the New York City Department of Transportation (NYCDOT) radio...

Test/QA Plan for Verification of Radio Frequency Identification (RFID) for Tracking Hazardous Waste Shipments across International Borders

EPA Science Inventory

The verification test will be conducted under the auspices of the U.S. Environmental Protection Agency (EPA) through the Environmental Technology Verification (ETV) Program. It will be performed by Battelle, which is managing the ETV Advanced Monitoring Systems (AMS) Center throu...

Systems Thinking: A Way to Understand Socio-political Environments

DTIC Science & Technology

2014-06-13

peasant farmer whose land was repossessed by coffee barons in the early 1900s. Motivated by communist literature during his early college years...offensive from the FMLN,” his Vice-Minister, who like Domingo was obsessed with eliminating the FMLN radio station, ordered Atlacatl to “advance no matter

Experimental demonstration of the anti-maser

NASA Astrophysics Data System (ADS)

Mazzocco, Anthony; Aviles, Michael; Andrews, Jim; Dawson, Nathan; Crescimanno, Michael

2012-10-01

We denote by ``anti-maser'' a coherent perfect absorption (CPA) process in the radio frequency domain. We demonstrate several experimental realizations of the anti-maser suitable for an advanced undergraduate laboratory. Students designed, assembled and tested these devices, as well as the inexpensive laboratory setup and experimental protocol for displaying various CPA phenomenon.

Sind Sie fit (Are You in Shape)?: Calisthenics in German.

ERIC Educational Resources Information Center

Wolter, Don

This packet of instructional materials, intended for intermediate and advanced German students, contains a student's section and a teacher's guide focusing on calisthenics. The student section contains three illustrated transcriptions of radio programs on calisthenics for early morning listeners of "Der bayrische Rundfunk" in West Germany.…

Rehabilitation Technology for the Blind in the United States.

ERIC Educational Resources Information Center

Jacobson, William H.

Research in the United States and abroad has led to advances in rehabilitation technology that enables blind and visually impaired persons to compete with sighted persons for employment. Relatively inexpensive devices such as pocket calculators, transistor radios, cassette recorders, and digital watches have become aids for the blind; some…

Education Technology Success Stories

ERIC Educational Resources Information Center

West, Darrell M.; Bleiberg, Joshua

2013-01-01

Advances in technology are enabling dramatic changes in education content, delivery, and accessibility. Throughout history, new technologies have facilitated the exponential growth of human knowledge. In the early twentieth century, the focus was on the use of radios in education. But since then, innovators have seen technology as a way to improve…

NRAO Scientists on Team Receiving International Astronautics Award

NASA Astrophysics Data System (ADS)

2005-10-01

The International Academy of Astronautics (IAA) is presenting an award to a pioneering team of scientists and engineers who combined an orbiting radio-astronomy satellite with ground-based radio telescopes around the world to produce a "virtual telescope" nearly three times the size of the Earth. The team, which includes two scientists from the National Radio Astronomy Observatory (NRAO), will receive the award in a ceremony Sunday, October 16, in Fukuoka, Japan. VSOP Satellite and Ground Telescopes Artist's conception of HALCA satellite and ground observatories together making "virtual telescope" (blue) about three times the size of Earth. CREDIT: ISAS, JAXA (Click on image for larger version) The IAA chose the VLBI Space Observatory Program (VSOP), an international collaboration, to receive its 2005 Laurels for Team Achievement Award, which recognizes "extraordinary performance and achievement by a team of scientists, engineers and managers in the field of Astronautics to foster its peaceful and international use." VSOP team members named in the IAA award include NRAO astronomers Edward Fomalont, of Charlottesville, Virginia, and Jonathan Romney, of Socorro, New Mexico. "This is a well-deserved award for an international team whose hard work produced a scientific milestone that yielded impressive results and provides a foundation for more advances in the future," said Dr. Fred K.Y Lo, NRAO Director. The VSOP program used a Japanese satellite, HALCA (Highly Advanced Laboratory for Communications and Astronomy), that included an 8-meter (26-foot) radio telescope. HALCA was launched in 1997 and made astronomical observations in conjunction with ground-based radio telescopes from 14 countries. Five tracking stations, including one at NRAO's Green Bank, West Virginia, facility, received data from HALCA which later was combined with data from the ground-based telescopes to produce images more detailed than those that could have been made by ground-based systems alone. The NRAO's Very Long Baseline Array (VLBA), a continent-wide system of radio telescopes ranging from Hawaii to the Caribbean, was one of the principal ground-based networks working with HALCA. The VLBA's powerful special-purpose computer, called a correlator, was a prime workhorse for processing the data from VSOP astronomical observations. Very long baseline interferometry (VLBI) is a technique used by radio astronomers to electronically link widely separated radio telescopes together so they work as if they were a single instrument with extraordinarily sharp "vision," or resolving power. The wider the distance, or "baselines" between telescopes, the greater the resolving power. The IAA award citation notes that the VSOP team "realized the long-held dream of radio astronomers to extend those baselines into space, by observing celestial radio sources with the HALCA satellite, supported by a dedicated network of tracking stations, and arrays of ground radio telescopes from around the world." The VSOP team was able to approximately triple the resolving power available with only ground-based telescopes. The first experiment in such space-ground observation was made in 1986, using a NASA Tracking and Data Relay Satellite. The VSOP project grew as an international effort after that experiment, and provided observing time to astronomers from around the world. During the VSOP observational program, the combined space-ground system made more than 780 individual astronomical observations and also made an all-sky survey of the cores of active galaxies. The VLBA The VLBA CREDIT: NRAO/AUI/NSF In addition to providing large amounts of observing time on the VLBA and building and operating the Green Bank tracking station, NRAO staff also modified existing hardware and software and aided astronomers from around the world in analyzing VSOP data. On behalf of the entire VSOP Team, the IAA highlighted "the astronomers and engineers who made key contributions to realizing, and operating, a radio telescope bigger than the Earth." In addition to Fomalont and Romney, they are: Hisashi Hirabayashi, of the Institute of Space and Astronautical Science and Japan Aerospace Exploration Agency (ISAS/JAXA), Haruto Hirosawa (ISAS/JAXA), Peter Dewdney of Canada's Dominion Radio Astrophysical Observatory, Leonid Gurvits of the Joint Institute for VLBI in Europe (JIVE, The Netherlands), Makoto Inoue of the National Astronomical Observatory of Japan (NAOJ), David Jauncey of the Australia Telescope National Facility, Noriyuki Kawaguchi (NAOJ), Hideyuki Kobayashi (NAOJ), Kazuo Miyoshi (Mitsubishi Electric Corporation, Japan), Yasuhiro Murata (ISAS/JAXA), Takeshi Orii (NEC, Japan) Robert Preston of NASA's Jet Propulsion Laboratory (JPL), and Joel Smith (JPL). The International Academy of Astronautics was founded in August 1960 in Stockholm, Sweden, during the 11th International Astronautical Congress. The Academy aims to foster the development of astronautics for peaceful purposes; recognize individuals who have distinguished themselves in a related branch of science or technology; provide a program through which members may contribute to international endeavours; cooperation in the advancement of aerospace science. Previous recipients of the Laurels for Team Achievement Award are the Russian Mir Space Station Team (2001), the U.S. Space Shuttle Team (2002), the Solar and Heliospheric Observatory (SOHO) Team (2003), and the Hubble Space Telescope Team (2004). The National Radio Astronomy Observatory is a facility of the National Science Foundation, operated under cooperative agreement by Associated Universities, Inc.

A Fixed Point VHDL Component Library for a High Efficiency Reconfigurable Radio Design Methodology

NASA Technical Reports Server (NTRS)

Hoy, Scott D.; Figueiredo, Marco A.

2006-01-01

Advances in Field Programmable Gate Array (FPGA) technologies enable the implementation of reconfigurable radio systems for both ground and space applications. The development of such systems challenges the current design paradigms and requires more robust design techniques to meet the increased system complexity. Among these techniques is the development of component libraries to reduce design cycle time and to improve design verification, consequently increasing the overall efficiency of the project development process while increasing design success rates and reducing engineering costs. This paper describes the reconfigurable radio component library developed at the Software Defined Radio Applications Research Center (SARC) at Goddard Space Flight Center (GSFC) Microwave and Communications Branch (Code 567). The library is a set of fixed-point VHDL components that link the Digital Signal Processing (DSP) simulation environment with the FPGA design tools. This provides a direct synthesis path based on the latest developments of the VHDL tools as proposed by the BEE VBDL 2004 which allows for the simulation and synthesis of fixed-point math operations while maintaining bit and cycle accuracy. The VHDL Fixed Point Reconfigurable Radio Component library does not require the use of the FPGA vendor specific automatic component generators and provide a generic path from high level DSP simulations implemented in Mathworks Simulink to any FPGA device. The access to the component synthesizable, source code provides full design verification capability:

Multimodality: a basis for augmentative and alternative communication--psycholinguistic, cognitive, and clinical/educational aspects.

PubMed

Loncke, Filip T; Campbell, Jamie; England, Amanda M; Haley, Tanya

2006-02-15

Message generating is a complex process involving a number of processes, including the selection of modes to use. When expressing a message, human communicators typically use a combination of modes. This phenomenon is often termed multimodality. This article explores the use of models that explain multimodality as an explanatory framework for augmentative and alternative communication (AAC). Multimodality is analysed from a communication, psycholinguistic, and cognitive perspective. Theoretical and applied topics within AAC can be explained or described within the multimodality framework considering iconicity, simultaneous communication, lexical organization, and compatibility of communication modes. Consideration of multimodality is critical to understanding underlying processes in individuals who use AAC and individuals who interact with them.

Mid-infrared multi-mode absorption spectroscopy, MUMAS, using difference frequency generation

NASA Astrophysics Data System (ADS)

Northern, Henry; O'Hagan, Seamus; Hamilton, Michelle L.; Ewart, Paul

2015-03-01

Multi-mode absorption spectroscopy of ammonia and methane at 3.3 μm has been demonstrated using a source of multi-mode mid-infrared radiation based on difference frequency generation. Multi-mode radiation at 1.56 μm from a diode-pumped Er:Yb:glass laser was mixed with a single-mode Nd:YAG laser at 1.06 μm in a periodically poled lithium niobate crystal to produce multi-mode radiation in the region of 3.3 μm. Detection, by direct multi-mode absorption, of NH3 and CH4 is reported for each species individually and also simultaneously in mixtures allowing measurements of partial pressures of each species.

Pre-Flight Testing and Performance of a Ka-Band Software Defined Radio

NASA Technical Reports Server (NTRS)

Downey, Joseph A.; Reinhart, Richard C.; Kacpura, Thomas

2012-01-01

National Aeronautics and Space Administration (NASA) has developed a space-qualified, reprogrammable, Ka-band Software Defined Radio (SDR) to be utilized as part of an on-orbit, reconfigurable testbed. The testbed will operate on the truss of the International Space Station beginning in late 2012. Three unique SDRs comprise the testbed, and each radio is compliant to the Space Telecommunications Radio System (STRS) Architecture Standard. The testbed provides NASA, industry, other Government agencies, and academic partners the opportunity to develop communications, navigation, and networking applications in the laboratory and space environment, while at the same time advancing SDR technology, reducing risk, and enabling future mission capability. Designed and built by Harris Corporation, the Ka-band SDR is NASA's first space-qualified Ka-band SDR transceiver. The Harris SDR will also mark the first NASA user of the Ka-band capabilities of the Tracking Data and Relay Satellite System (TDRSS) for on-orbit operations. This paper describes the testbed's Ka-band System, including the SDR, travelling wave tube amplifier (TWTA), and antenna system. The reconfigurable aspects of the system enabled by SDR technology are discussed and the Ka-band system performance is presented as measured during extensive pre-flight testing.

The Impact of Radio Interference on Future Radio Telescopes

NASA Astrophysics Data System (ADS)

Mitchell, Daniel A.; Robertson, Gordon J.; Sault, Robert J.

While future radio telescopes will require technological advances from the communications industry interference from sources such as satellites and mobile phones is a serious concern. In addition to the fact that the level of interference is growing constantly the increased capabilities of next generation instruments make them more prone to harmful interference. These facilities must have mechanisms to allow operation in a crowded spectrum. In this report some of the factors which may limit the effectiveness of these mechanisms are investigated. Radio astronomy is unique among other observing wavelengths in that the radiation can be fully sampled at a rate which completely specifies the electromagnetic environment. Knowledge of phases and antennae gain factors affords one the opportunity to attempt to mitigate interference from the astronomical data. At present several interference mitigation techniques have been demonstrated to be extremely effective. However the observational scales of the new facilities will push the techniques to their limits. Processes such as signal decorrelation varying antenna gain and instabilities in the primary beam will have a serious effect on some of the algorithms. In addition the sheer volume of data produced will render some techniques computationally and financially impossible.

Progress in Small Molecule Therapeutics for the Treatment of Retinoblastoma

PubMed Central

Pritchard, Eleanor M.; Dyer, Michael A.; Guy, R. Kiplin

2017-01-01

While mortality is low for intraocular retinoblastoma patients in the developed world who receive aggressive multimodal therapy, partial or full loss of vision occurs in approximately 50% of patients with advanced bilateral retinoblastoma. Therapies that preserve vision and reduce late effects are needed. Because clinical trials for retinoblastoma are difficult due to the young age of the patient population and relative rarity of the disease, robust preclinical testing of new therapies is critical. The last decade has seen advances towards identifying new therapies including the development of animal models of retinoblastoma for preclinical testing, progress in local drug delivery to reach intraocular targets, and improved understanding of the underlying biological mechanisms that give rise to retinoblastoma. This review discusses advances in these areas, with a focus on discovery and development of small molecules for the treatment of retinoblastoma, including novel targeted therapeutics such as inhibitors of the MDMX-p53 interaction (nutlin-3a), histone deacetylase (HDAC) inhibitors, and spleen tyrosine kinase (SYK) inhibitors. PMID:26202204

Progress in Small Molecule Therapeutics for the Treatment of Retinoblastoma.

PubMed

Pritchard, Eleanor M; Dyer, Michael A; Guy, R Kiplin

2016-01-01

While mortality is low for intraocular retinoblastoma patients in the developed world who receive aggressive multimodal therapy, partial or full loss of vision occurs in approximately 50% of patients with advanced bilateral retinoblastoma. Therapies that preserve vision and reduce late effects are needed. Because clinical trials for retinoblastoma are difficult due to the young age of the patient population and relative rarity of the disease, robust preclinical testing of new therapies is critical. The last decade has seen advances towards identifying new therapies including the development of animal models of retinoblastoma for preclinical testing, progress in local drug delivery to reach intraocular targets, and improved understanding of the underlying biological mechanisms that give rise to retinoblastoma. This review discusses advances in these areas, with a focus on discovery and development of small molecules for the treatment of retinoblastoma, including novel targeted therapeutics such as inhibitors of the MDMX-p53 interaction (nutlin-3a), histone deacetylase (HDAC) inhibitors, and spleen tyrosine kinase (SYK) inhibitors.

Good Student/Bad Student: Situated Identities in the Figured Worlds of School and Creative Multimodal Production

ERIC Educational Resources Information Center

Jocius, Robin

2017-01-01

This study situates young adolescents' multimodal composing practices within two figured worlds--school and creative multimodal production. In a microanalysis of two focal students' multimodal processes and products, I trace how pedagogical, interactional, and semiotic resources both reified and challenged students' developing identities as…

Using Shaun Tan's Work to Foster Multiliteracies in 21st-Century Classrooms

ERIC Educational Resources Information Center

Dallacqua, Ashley K.; Kersten, Sara; Rhoades, Mindi

2015-01-01

This paper explores work in multimodality and design as it relates to 21st century multiliteracies. After outlining the concept of a multiliteracies pedagogy, this paper describes multimodality and multimodal texts. Moving from the theoretical to the practical, this paper primarily explores selected multimodal works of Shaun Tan and the…

Multimodal Hip Hop Productions as Media Literacies

ERIC Educational Resources Information Center

Turner, K. C. Nat

2012-01-01

This study draws on ethnographic data from a year-long multimodal media production (MMP) course and the experience of an African American female adolescent who used the production of multimodal Hip Hop texts to express her creativity and growing socially conscious view of the world. The study demonstrates how students made meaning multimodally and…

Towards an intelligent framework for multimodal affective data analysis.

PubMed

Poria, Soujanya; Cambria, Erik; Hussain, Amir; Huang, Guang-Bin

2015-03-01

An increasingly large amount of multimodal content is posted on social media websites such as YouTube and Facebook everyday. In order to cope with the growth of such so much multimodal data, there is an urgent need to develop an intelligent multi-modal analysis framework that can effectively extract information from multiple modalities. In this paper, we propose a novel multimodal information extraction agent, which infers and aggregates the semantic and affective information associated with user-generated multimodal data in contexts such as e-learning, e-health, automatic video content tagging and human-computer interaction. In particular, the developed intelligent agent adopts an ensemble feature extraction approach by exploiting the joint use of tri-modal (text, audio and video) features to enhance the multimodal information extraction process. In preliminary experiments using the eNTERFACE dataset, our proposed multi-modal system is shown to achieve an accuracy of 87.95%, outperforming the best state-of-the-art system by more than 10%, or in relative terms, a 56% reduction in error rate. Copyright © 2014 Elsevier Ltd. All rights reserved.

Performance Evaluation of Multimodal Multifeature Authentication System Using KNN Classification.

PubMed

Rajagopal, Gayathri; Palaniswamy, Ramamoorthy

2015-01-01

This research proposes a multimodal multifeature biometric system for human recognition using two traits, that is, palmprint and iris. The purpose of this research is to analyse integration of multimodal and multifeature biometric system using feature level fusion to achieve better performance. The main aim of the proposed system is to increase the recognition accuracy using feature level fusion. The features at the feature level fusion are raw biometric data which contains rich information when compared to decision and matching score level fusion. Hence information fused at the feature level is expected to obtain improved recognition accuracy. However, information fused at feature level has the problem of curse in dimensionality; here PCA (principal component analysis) is used to diminish the dimensionality of the feature sets as they are high dimensional. The proposed multimodal results were compared with other multimodal and monomodal approaches. Out of these comparisons, the multimodal multifeature palmprint iris fusion offers significant improvements in the accuracy of the suggested multimodal biometric system. The proposed algorithm is tested using created virtual multimodal database using UPOL iris database and PolyU palmprint database.

Performance Evaluation of Multimodal Multifeature Authentication System Using KNN Classification

PubMed Central

Rajagopal, Gayathri; Palaniswamy, Ramamoorthy

2015-01-01

This research proposes a multimodal multifeature biometric system for human recognition using two traits, that is, palmprint and iris. The purpose of this research is to analyse integration of multimodal and multifeature biometric system using feature level fusion to achieve better performance. The main aim of the proposed system is to increase the recognition accuracy using feature level fusion. The features at the feature level fusion are raw biometric data which contains rich information when compared to decision and matching score level fusion. Hence information fused at the feature level is expected to obtain improved recognition accuracy. However, information fused at feature level has the problem of curse in dimensionality; here PCA (principal component analysis) is used to diminish the dimensionality of the feature sets as they are high dimensional. The proposed multimodal results were compared with other multimodal and monomodal approaches. Out of these comparisons, the multimodal multifeature palmprint iris fusion offers significant improvements in the accuracy of the suggested multimodal biometric system. The proposed algorithm is tested using created virtual multimodal database using UPOL iris database and PolyU palmprint database. PMID:26640813

Practical multimodal care for cancer cachexia.

PubMed

Maddocks, Matthew; Hopkinson, Jane; Conibear, John; Reeves, Annie; Shaw, Clare; Fearon, Ken C H

2016-12-01

Cancer cachexia is common and reduces function, treatment tolerability and quality of life. Given its multifaceted pathophysiology a multimodal approach to cachexia management is advocated for, but can be difficult to realise in practice. We use a case-based approach to highlight practical approaches to the multimodal management of cachexia for patients across the cancer trajectory. Four cases with lung cancer spanning surgical resection, radical chemoradiotherapy, palliative chemotherapy and no anticancer treatment are presented. We propose multimodal care approaches that incorporate nutritional support, exercise, and anti-inflammatory agents, on a background of personalized oncology care and family-centred education. Collectively, the cases reveal that multimodal care is part of everyone's remit, often focuses on supported self-management, and demands buy-in from the patient and their family. Once operationalized, multimodal care approaches can be tested pragmatically, including alongside emerging pharmacological cachexia treatments. We demonstrate that multimodal care for cancer cachexia can be achieved using simple treatments and without a dedicated team of specialists. The sharing of advice between health professionals can help build collective confidence and expertise, moving towards a position in which every team member feels they can contribute towards multimodal care.

Increasing knowledge of best practices for occupational therapists treating post-stroke unilateral spatial neglect: results of a knowledge-translation intervention study.

PubMed

Petzold, Anita; Korner-Bitensky, Nicol; Salbach, Nancy M; Ahmed, Sara; Menon, Anita; Ogourtsova, Tatiana

2012-02-01

The aim of this study was to investigate: (i) the feasibility of delivering a multi-modal knowledge translation intervention specific to the management of acute post-stroke unilateral spatial neglect; and (ii) the impact of the knowledge translation intervention on occupational therapists' knowledge of evidence-based unilateral spatial neglect problem identification, assessment and treatment, and self-efficacy related to evidence-based practice implementation. A 3-period (pre-post) repeated measures design. Acute care occupational therapists treating patients with post-stroke unilateral spatial neglect were recruited from two major Canadian cities. Participants completed two pre-intervention assessments, took part in a day-long interactive multi-modal knowledge translation intervention and a subsequent 8-week follow-up, and completed a post-intervention assessment. Knowledge of evidence-based problem identification, assessment and treatment of unilateral spatial neglect, and self-efficacy to perform evidence-based practice activities were measured using standard scales. The intervention was tested on 20 occupational therapists. Results indicate a significant improvement in knowledge of best practice unilateral spatial neglect management (p < 0.000) and evidence-based practice self-efficacy in carrying out evidence-based practice activities (p < 0.045) post-intervention. Use of a multi-modal knowledge translation intervention is feasible and can significantly improve occupational therapists' knowledge of unilateral spatial neglect best practices and self-efficacy. The findings should help advance best practices specific to the management of post-stroke unilateral spatial neglect as well as informing knowledge translation studies in other areas of practice.

Nanoelectronics enabled chronic multimodal neural platform in a mouse ischemic model

PubMed Central

Luan, Lan; Sullender, Colin T.; Li, Xue; Zhao, Zhengtuo; Zhu, Hanlin; Wei, Xiaoling; Xie, Chong; Dunn, Andrew K.

2018-01-01

Background Despite significant advancements of optical imaging techniques for mapping hemodynamics in small animal models, it remains challenging to combine imaging with spatially resolved electrical recording of individual neurons especially for longitudinal studies. This is largely due to the strong invasiveness to the living brain from the penetrating electrodes and their limited compatibility with longitudinal imaging. New Method We implant arrays of ultraflexible nanoelectronic threads (NETs) in mice for neural recording both at the brain surface and intracortically, which maintain great tissue compatibility chronically. By mounting a cranial window atop of the NET arrays that allows for chronic optical access, we establish a multimodal platform that combines spatially resolved electrical recording of neural activity and laser speckle contrast imaging (LSCI) of cerebral blood flow (CBF) for longitudinal studies. Results We induce peri-infarct depolarizations (PIDs) by targeted photothrombosis, and show the ability to detect its occurrence and propagation through spatiotemporal variations in both extracellular potentials and CBF. We also demonstrate chronic tracking of single-unit neural activity and CBF over days after photothrombosis, from which we observe reperfusion and increased firing rates. Comparison with Existing Method(s) This multimodal platform enables simultaneous mapping of neural activity and hemodynamic parameters at the microscale for quantitative, longitudinal comparisons with minimal perturbation to the baseline neurophysiology. Conclusion The ability to spatiotemporally resolve and chronically track CBF and neural electrical activity in the same living brain region has broad applications for studying the interplay between neural and hemodynamic responses in health and in cerebrovascular and neurological pathologies. PMID:29203409

Status of the implementation of the World Health Organization multimodal hand hygiene strategy in United States of America health care facilities.

PubMed

Allegranzi, Benedetta; Conway, Laurie; Larson, Elaine; Pittet, Didier

2014-03-01

The World Health Organization (WHO) launched a multimodal strategy and campaign in 2009 to improve hand hygiene practices worldwide. Our objective was to evaluate the implementation of the strategy in United States health care facilities. From July through December 2011, US facilities participating in the WHO global campaign were invited to complete the Hand Hygiene Self-Assessment Framework online, a validated tool based on the WHO multimodal strategy. Of 2,238 invited facilities, 168 participated in the survey (7.5%). A detailed analysis of 129, mainly nonteaching public facilities (80.6%), showed that most had an advanced or intermediate level of hand hygiene implementation progress (48.9% and 45.0%, respectively). The total Hand Hygiene Self-Assessment Framework score was 36 points higher for facilities with staffing levels of infection preventionists > 0.75/100 beds than for those with lower ratios (P = .01) and 41 points higher for facilities participating in hand hygiene campaigns (P = .002). Despite the low response rate, the survey results are unique and allow interesting reflections. Whereas the level of progress of most participating facilities was encouraging, this may reflect reporting bias, ie, better hospitals more likely to report. However, even in respondents, further improvement can be achieved, in particular by embedding hand hygiene in a stronger institutional safety climate and optimizing staffing levels dedicated to infection prevention. These results should encourage the launch of a coordinated national campaign and higher participation in the WHO global campaign. Copyright © 2014 World Health Organization. Published by Mosby, Inc. All rights reserved.

Status of the implementation of the World Health Organization multimodal hand hygiene strategy in United States of America health care facilities

PubMed Central

Allegranzi, Benedetta; Conway, Laurie; Larson, Elaine; Pittet, Didier

2014-01-01

Background The World Health Organization (WHO) launched a multimodal strategy and campaign in 2009 to improve hand hygiene practices worldwide. Our objective was to evaluate the implementation of the strategy in United States health care facilities. Methods From July through December 2011, US facilities participating in the WHO global campaign were invited to complete the Hand Hygiene Self-Assessment Framework online, a validated tool based on the WHO multimodal strategy. Results Of 2,238 invited facilities, 168 participated in the survey (7.5%). A detailed analysis of 129, mainly nonteaching public facilities (80.6%), showed that most had an advanced or intermediate level of hand hygiene implementation progress (48.9% and 45.0%, respectively). The total Hand Hygiene Self-Assessment Framework score was 36 points higher for facilities with staffing levels of infection preventionists > 0.75/100 beds than for those with lower ratios (P = .01) and 41 points higher for facilities participating in hand hygiene campaigns (P = .002). Conclusion Despite the low response rate, the survey results are unique and allow interesting reflections. Whereas the level of progress of most participating facilities was encouraging, this may reflect reporting bias, ie, better hospitals more likely to report. However, even in respondents, further improvement can be achieved, in particular by embedding hand hygiene in a stronger institutional safety climate and optimizing staffing levels dedicated to infection prevention. These results should encourage the launch of a coordinated national campaign and higher participation in the WHO global campaign. PMID:24581011

Big-Data Perspective to Operating an SKA-Type Synthesis Array Radio Telescope

NASA Astrophysics Data System (ADS)

Shanmugha Sundaram, GA

2015-08-01

Of the two forerunner sites, viz. Australia and South Africa, where pioneering advancements to state-of-the-art in synthesis array radio astronomy instrumentation are being attempted in the form of pathfinders to the Square Kilometer Array (SKA), for its eventual deployment, a diversity of site-dependent topology and design metrics exists. Towards addressing some of the fundamental mysteries in physics at the micro- and macro-cosm levels, that form the Key Science Projects (KSPs) for the SKA, and interfacing them to an optimally designed array conguration, a critical evaluation of their radio imaging capabilities and metrics becomes paramount. Here, the various KSPs and instrument design specifications are discussed, for relative merits and adaptability to either site, from invoking well-founded and established array-design and optimization principles designed into a customized software tool. Since the problem of array design is one that encompasses variables on several scales such as separation distances between the radio interferometric pair (termed the baseline), factors such as redundancy, flux and phase calibration, bandwidth, integration time, clock synchronization for the correlation process at the detector, and many other ambient-defined parameters, there is a significant component of big data involved in the complex visibilities that are to be Fourier transformed from the spatial to the radio-sky domain (to generate a radio sky map) using vast computational infrastructure, with robust data connectivity and data handling facilities to support this. A crucial requirement exists to make the general public aware of the implications of such a massive scale scientific and technological venture, which shall be the focus of this presentation.

Gravitational time advancement under gravity's rainbow

NASA Astrophysics Data System (ADS)

Deng, Xue-Mei; Xie, Yi

2017-09-01

Under gravity's rainbow, we investigate its effects on the gravitational time advancement, which is a natural consequence of measuring proper time span for a photon's round trip. This time advancement can be complementary to the time delay for testing the gravity's rainbow, because they are sensitive to different modified dispersion relations (MDRs). Its observability on ranging a spacecraft far from the Earth by two radio and a laser links is estimated at superior conjunction (SC) and inferior conjunction (IC). We find that (1) the IC is more favorable than the SC for measurement on the advancement caused by the rainbow; (2) a specific type of MDR has a significantly larger effect on the advancement than others in both SC and IC cases; and (3) a combination of available optical clocks and the realization of planetary laser ranging in the future will benefit distinguishing the gravity's rainbow from GR by measuring the gravitational time advancement.

Effect of orientational ordering of magnetic nanoemulsions immobilized in agar gel on magnetic hyperthermia

NASA Astrophysics Data System (ADS)

Lahiri, B. B.; Ranoo, Surojit; Philip, John

2018-04-01

Magnetic nanoemulsions of droplet size ∼200 nm, loaded with single domain superparamagnetic nanoparticles (MNP), are potential candidates for multimodal hyperthermia due to availability of large loading volume and enhanced permeation and retention (EPR) in the cancerous tissues. In such nanoemulsions, radio frequency alternating magnetic field induced heating occur at two entirely different length scales, viz. Neel-Brown relaxation of the dispersed MNP and Brownian relaxation of emulsion droplets. Here we study the effects of orientation ordering or texturing of droplets, immobilized in a tissue mimicking agar matrix, on the field induced heating efficiency. A higher specific absorption rate (maximum ∼73 ± 2 W/gFe) is observed for droplets orientated parallel to the direction of the alternating magnetic field because of the enhancement of effective uniaxial anisotropy energy density and increased effective relaxation time. For identical and non-interacting MNP oriented parallel to the external DC magnetic field, a threefold increase in the effective uniaxial anisotropy energy density and ∼20-30% increased specific absorption rate are observed as compared to those oriented perpendicular to the magnetic field. Magnetic force microscopy images showed that the spherical morphology of the droplets remains intact even after orientational ordering and average topographic height of the droplets are found to be ∼220 (±17) nm, which is in good agreement with the most probable size obtained from dynamic light scattering. The residual volume magnetization of the emulsion droplets is found to be 1.1 × 10-6 emu/cc, indicating the superparamagnetic nature of the droplets in tissue equivalent environment. The observed increase in heating efficiency of the immobilized and oriented emulsion droplets shows promising applications in multimodal hyperthermia therapy because of the requirement of lower dose of MNP and shorter treatment time.

LAT1 targeted delivery of methionine based imaging probe derived from M(III) metal ions for early diagnosis of proliferating tumours using molecular imaging modalities.

PubMed

Hazari, Puja Panwar; Prakash, Surbhi; Meena, Virendra K; Jaswal, Ambika; Khurana, Harleen; Mishra, Surabhi Kirti; Bhonsle, Hemanth Kumar; Singh, Lokendra; Mishra, Anil K

2015-01-01

We investigated the potential of DTPA-bis(Methionine), a target specific amino acid based probe for detection of L-type amino acid transporters (LAT1) known to over express in proliferating tumours using multimodality imaging. The ligand, DTPA-bis(Met) was readily converted to lanthanide complexes and was found capable of targeting cancer cells using multimodality imaging. DTPA-bis(Met) complexes were synthesized and characterized by mass spectroscopy. MR longitudinal relaxivity, r₁ = 4.067 ± 0.31 mM⁻¹s⁻¹ and transverse relaxivity, r₂ = 8.61 ± 0.07 mM⁻¹s⁻¹ of Gd(III)-DTPA-bis(Met) were observed at pH 7.4 at 7 T. Bright, localized fluorescence of Eu(III)-DTPA-bis(Met) was observed with standard microscopy and displacement studies indicated ligand functionality. K(D) value determined for Eu(III)-DTPA-bis(Met) on U-87 MG cells was found to be 17.3 pM and showed appreciable fluorescence within the cells. Radio HPLC showed a radiochemical purity more than 95% (specific activity = 400-500 MBq/μmol, labelling efficiency 78 %) for ⁶⁸Ga(III)-DTPA-bis(Met). Pre-treatment of xenografted U-87 MG athymic mice with ⁶⁸Ga(III)-DTPA-bis(Met) following unlabelled L-methionine administration reduced tumour uptake by 10-folds in Micro PET. These data support the specific binding of ⁶⁸Ga(III)-DTPA-bis(Met) to the LAT1 transporter. To summarize, this agent possesses high stability in biological environment and exhibits effective interaction with its LAT1 transporters giving high accumulation in tumour area, excellent tumour/non-tumour ratio and low non-specific retention in vivo.

Atom Probe Tomographic Analysis of Biological Systems Enabled by Advanced Specimen Preparation Approaches

NASA Astrophysics Data System (ADS)

Perea, D. E.; Evans, J. E.

2017-12-01

The ability to image biointerfaces over nanometer to micrometer length scales is fundamental to correlating biological composition and structure to physiological function, and is aided by a multimodal approach using advanced complementary microscopic and spectroscopic characterization techniques. Atom Probe Tomography (APT) is a rapidly expanding technique for atomic-scale three-dimensional structural and chemical analysis. However, the regular application of APT to soft biological materials is lacking in large part due to difficulties in specimen preparation and inabilities to yield meaningful tomographic reconstructions that produce atomic scale compositional distributions as no other technique currently can. Here we describe the atomic-scale tomographic analysis of biological materials using APT that is facilitated by an advanced focused ion beam based approach. A novel specimen preparation strategy is used in the analysis of horse spleen ferritin protein embedded in an organic polymer resin which provides chemical contrast to distinguish the inorganic-organic interface of the ferrihydrite mineral core and protein shell of the ferritin protein. One-dimensional composition profiles directly reveal an enhanced concentration of P and Na at the surface of the ferrihydrite mineral core. We will also describe the development of a unique multifunctional environmental transfer hub allowing controlled cryogenic transfer of specimens under vacuum pressure conditions between an Atom Probe and cryo-FIB/SEM. The utility of the environmental transfer hub is demonstrated through the acquisition of previously unavailable mass spectral analysis of an intact organometallic molecule made possible via controlled cryogenic transfer. The results demonstrate a viable application of APT analysis to study complex biological organic/inorganic interfaces relevant to energy and the environment. References D.E. Perea et al. An environmental transfer hub for multimodal atom probe tomography, Adv. Struct. Chem. Imag, 2017, 3:12 The research was performed at the Environmental Molecular Sciences Laboratory; a national scientific user facility sponsored by the Department of Energy's Office of Biological and Environmental Research located at Pacific Northwest National Laboratory.

New Technologies, New Possibilities for the Arts and Multimodality in English Language Arts

ERIC Educational Resources Information Center

Williams, Wendy R.

2014-01-01

This article discusses the arts, multimodality, and new technologies in English language arts. It then turns to the example of the illuminated text--a multimodal book report consisting of animated text, music, and images--to consider how art, multimodality, and technology can work together to support students' reading of literature and inspire…

Multimode fiber devices with single-mode performance

NASA Astrophysics Data System (ADS)

Leon-Saval, S. G.; Birks, T. A.; Bland-Hawthorn, J.; Englund, M.

2005-10-01

A taper transition can couple light between a multimode fiber and several single-mode fibers. If the number of single-mode fibers matches the number of spatial modes in the multimode fiber, the transition can have low loss in both directions. This enables the high performance of single-mode fiber devices to be attained in multimode fibers. We report an experimental proof of concept by using photonic crystal fiber techniques to make the transitions, demonstrating a multimode fiber filter with the transmission spectrum of a single-mode fiber grating.

Frequency Agile Transceiver for Advanced Vehicle Data Links

NASA Technical Reports Server (NTRS)

Freudinger, Lawrence C.; Macias, Filiberto; Cornelius, Harold

2009-01-01

Emerging and next-generation test instrumentation increasingly relies on network communication to manage complex and dynamic test scenarios, particularly for uninhabited autonomous systems. Adapting wireless communication infrastructure to accommodate challenging testing needs can benefit from reconfigurable radio technology. Frequency agility is one characteristic of reconfigurable radios that to date has seen only limited progress toward programmability. This paper overviews an ongoing project to validate a promising chipset that performs conversion of RF signals directly into digital data for the wireless receiver and, for the transmitter, converts digital data into RF signals. The Software Configurable Multichannel Transceiver (SCMT) enables four transmitters and four receivers in a single unit, programmable for any frequency band between 1 MHz and 6 GHz.

Methods and successes of New York University workshops for science graduate students and post-docs in science writing for general audiences (readers and radio listeners)

NASA Astrophysics Data System (ADS)

Hall, S. S.

2012-12-01

Scientists and science administrators often stress the importance of communication to the general public, but rarely develop educational infrastructures to achieve this goal. Since 2009, the Arthur L. Carter Journalism Institute at New York University has offered a series of basic and advanced writing workshops for graduate students and post-docs in NYU's eight scientific divisions (neuroscience, psychology, physics, biology, chemistry, mathematics, anthropology, and computer science). The basic methodology of the NYU approach will be described, along with successful examples of both written and radio work by students that have been either published or broadcast by general interest journalism outlets.

The search for extra-terrestrial intelligence.

PubMed

Drake, Frank

2011-02-13

Modern history of the search for extra-terrestrial intelligence is reviewed. The history of radio searches is discussed, as well as the major advances that have occurred in radio searches and prospects for new instruments and search strategies. Recent recognition that searches for optical and infrared signals make sense, and the reasons for this are described, as well as the equipment and special detection methods used in optical searches. The long-range future of the search for extra-terrestrial intelligence (SETI) is discussed in the context of the history of rapid change, on the cosmic and even the human time scale, of the paradigms guiding SETI searches. This suggests that SETI searches be conducted with a very open mind.

An innovative, highly sensitive receiver system for the Square Kilometre Array Mid Radio Telescope

NASA Astrophysics Data System (ADS)

Tan, Gie Han; Lehmensiek, Robert; Billade, Bhushan; Caputa, Krzysztof; Gauffre, Stéphane; Theron, Isak P.; Pantaleev, Miroslav; Ljusic, Zoran; Quertier, Benjamin; Peens-Hough, Adriaan

2016-07-01

The Square Kilometre Array (SKA) Project is a global science and engineering project realizing the next-generation radio telescopes operating in the metre and centimetre wavelengths regions. This paper addresses design concepts of the broadband, exceptionally sensitive receivers and reflector antennas deployed in the SKA1-Mid radio telescope to be located in South Africa. SKA1-Mid (350 MHz - 13.8 GHz with an option for an upper limit of 24 GHz) will consist of 133 reflector antennas using an unblocked aperture, offset Gregorian configuration with an effective diameter of 15 m. Details on the unblocked aperture Gregorian antennas, low noise front ends and advanced direct digitization receivers, are provided from a system design perspective. The unblocked aperture results in increased aperture efficiency and lower side-lobe levels compared to a traditional on-axis configuration. The low side-lobe level reduces the noise contribution due to ground pick-up but also makes the antenna less susceptible to ground-based RFI sources. The addition of extra shielding on the sub-reflector provides a further reduction of ground pick-up. The optical design of the SKA1-Mid reflector antenna has been tweaked using advanced EM simulation tools in combination with sophisticated models for sky, atmospheric and ground noise contributions. This optimal antenna design in combination with very low noise, partially cryogenic, receivers and wide instantaneous bandwidth provide excellent receiving sensitivity in combination with instrumental flexibility to accommodate a wide range of astronomical observation modes.

Recent Advances of VCSEL Photonics

NASA Astrophysics Data System (ADS)

Koyama, Fumio

2006-12-01

A vertical-cavity surface emitting laser (VCSEL) was invented 30 years ago. A lot of unique features can be expected, such as low-power consumption, wafer-level testing, small packaging capability, and so on. The market of VCSELs has been growing up rapidly in recent years, and they are now key devices in local area networks using multimode optical fibers. Also, long wavelength VCSELs are currently attracting much interest for use in single-mode fiber metropolitan area and wide area network applications. In addition, a VCSEL-based disruptive technology enables various consumer applications such as a laser mouse and laser printers. In this paper, the recent advance of VCSEL photonics will be reviewed, which include the wavelength extension of single-mode VCSELs and their wavelength integration/control. Also, this paper explores the potential and challenges for new functions of VCSELs toward optical signal processing.

Multimodality Therapy and Liver Transplantation for Hepatocellular Carcinoma: A 14-Year Prospective Analysis of Outcomes

PubMed Central

Ramanathan, Rajesh; Sharma, Amit; Lee, David D; Behnke, Martha; Bornstein, Karen; Stravitz, R Todd; Sydnor, Malcolm; Fulcher, Ann; Cotterell, Adrian; Posner, Marc P; Fisher, Robert A

2014-01-01

Background Hepatocellular carcinoma is a major cause of death among patients with cirrhosis. A standardized approach of multimodality therapy with intent-to-treat by transplantation for all patients with hepatocellular carcinoma was instituted at our transplant center in 1997. Data were prospectively collected to evaluate the impact of multimodality therapy on post-transplant patient survival, tumor recurrence and patient survival without transplantation. Methods All patients with hepatocellular carcinoma were eligible for multimodality therapy. Multimodality therapy consisted of hepatic resection, radiofrequency ablation, transarterial chemoembolization, transarterial chemoinfusion, yttrium-90 microsphere radioembolization and sorafenib. Results 715 patients underwent multimodality therapy. 231 patients were included in the intent-to-treat with transplantation arm and 484 patients were treated with multimodality therapy or palliative therapy due to contraindications for transplantation. A 60.2% transplantation rate was achieved in the intent-to-treat with transplantation arm. Post-transplant survivals at 1- and 5-years were 97.1% and 72.5% respectively. Tumor recurrence rates at 1-, 3- and 5-years were 2.4%, 6.2% and 11.6% respectively. Patients with contraindications to transplant had increased 1- and 5-year survival from diagnosis with multimodality therapy compared to those not treated (73.1% and 46.5% vs. 15.5% and 4.4%, p<0.0001). Conclusions Using multimodality therapy prior to liver transplantation for hepatocellular carcinoma achieved low recurrence rates and post-transplant survival equivalent to patients with primary liver disease without hepatocellular carcinoma. Multimodality therapy may help identify patients with less active tumor biology and result in improved disease-free survival and organ utilization. PMID:24503764

An integrated GIS-based data model for multimodal urban public transportation analysis and management

NASA Astrophysics Data System (ADS)

Chen, Shaopei; Tan, Jianjun; Ray, C.; Claramunt, C.; Sun, Qinqin

2008-10-01

Diversity is one of the main characteristics of transportation data collected from multiple sources or formats, which can be extremely complex and disparate. Moreover, these multimodal transportation data are usually characterised by spatial and temporal properties. Multimodal transportation network data modelling involves both an engineering and research domain that has attracted the design of a number of spatio-temporal data models in the geographic information system (GIS). However, the application of these specific models to multimodal transportation network is still a challenging task. This research addresses this challenge from both integrated multimodal data organization and object-oriented modelling perspectives, that is, how a complex urban transportation network should be organized, represented and modeled appropriately when considering a multimodal point of view, and using object-oriented modelling method. We proposed an integrated GIS-based data model for multimodal urban transportation network that lays a foundation to enhance the multimodal transportation network analysis and management. This modelling method organizes and integrates multimodal transit network data, and supports multiple representations for spatio-temporal objects and relationship as both visual and graphic views. The data model is expressed by using a spatio-temporal object-oriented modelling method, i.e., the unified modelling language (UML) extended to spatial and temporal plug-in for visual languages (PVLs), which provides an essential support to the spatio-temporal data modelling for transportation GIS.

S-Band propagation measurements

NASA Technical Reports Server (NTRS)

Briskman, Robert D.

1994-01-01

A geosynchronous satellite system capable of providing many channels of digital audio radio service (DARS) to mobile platforms within the contiguous United States using S-band radio frequencies is being implemented. The system is designed uniquely to mitigate both multipath fading and outages from physical blockage in the transmission path by use of satellite spatial diversity in combination with radio frequency and time diversity. The system also employs a satellite orbital geometry wherein all mobile platforms in the contiguous United States have elevation angles greater than 20 deg to both of the diversity satellites. Since implementation of the satellite system will require three years, an emulation has been performed using terrestrial facilities in order to allow evaluation of DARS capabilities in advance of satellite system operations. The major objective of the emulation was to prove the feasibility of broadcasting from satellites 30 channels of CD quality programming using S-band frequencies to an automobile equipped with a small disk antenna and to obtain quantitative performance data on S-band propagation in a satellite spatial diversity system.

HF propagation results from the Metal Oxide Space Cloud (MOSC) experiment

NASA Astrophysics Data System (ADS)

Joshi, Dev; Groves, Keith M.; McNeil, William; Carrano, Charles; Caton, Ronald G.; Parris, Richard T.; Pederson, Todd R.; Cannon, Paul S.; Angling, Matthew; Jackson-Booth, Natasha

2017-06-01

With support from the NASA sounding rocket program, the Air Force Research Laboratory launched two sounding rockets in the Kwajalein Atoll, Marshall Islands in May 2013 known as the Metal Oxide Space Cloud experiment. The rockets released samarium metal vapor at preselected altitudes in the lower F region that ionized forming a plasma cloud. Data from Advanced Research Project Agency Long-range Tracking and Identification Radar incoherent scatter radar and high-frequency (HF) radio links have been analyzed to understand the impacts of the artificial ionization on radio wave propagation. The HF radio wave ray-tracing toolbox PHaRLAP along with ionospheric models constrained by electron density profiles measured with the ALTAIR radar have been used to successfully model the effects of the cloud on HF propagation. Up to three new propagation paths were created by the artificial plasma injections. Observations and modeling confirm that the small amounts of ionized material injected in the lower F region resulted in significant changes to the natural HF propagation environment.

Wide field imaging problems in radio astronomy

NASA Astrophysics Data System (ADS)

Cornwell, T. J.; Golap, K.; Bhatnagar, S.

2005-03-01

The new generation of synthesis radio telescopes now being proposed, designed, and constructed face substantial problems in making images over wide fields of view. Such observations are required either to achieve the full sensitivity limit in crowded fields or for surveys. The Square Kilometre Array (SKA Consortium, Tech. Rep., 2004), now being developed by an international consortium of 15 countries, will require advances well beyond the current state of the art. We review the theory of synthesis radio telescopes for large fields of view. We describe a new algorithm, W projection, for correcting the non-coplanar baselines aberration. This algorithm has improved performance over those previously used (typically an order of magnitude in speed). Despite the advent of W projection, the computing hardware required for SKA wide field imaging is estimated to cost up to $500M (2015 dollars). This is about half the target cost of the SKA. Reconfigurable computing is one way in which the costs can be decreased dramatically.

Uncertainty in estimates of the number of extraterrestrial civilizations

NASA Technical Reports Server (NTRS)

Sturrock, P. A.

1980-01-01

An estimation of the number N of communicative civilizations is made by means of Drake's formula which involves the combination of several quantities, each of which is to some extent uncertain. It is shown that the uncertainty in any quantity may be represented by a probability distribution function, even if that quantity is itself a probability. The uncertainty of current estimates of N is derived principally from uncertainty in estimates of the lifetime of advanced civilizations. It is argued that this is due primarily to uncertainty concerning the existence of a Galactic Federation which is in turn contingent upon uncertainty about whether the limitations of present-day physics are absolute or (in the event that there exists a yet undiscovered hyperphysics) transient. It is further argued that it is advantageous to consider explicitly these underlying assumptions in order to compare the probable numbers of civilizations operating radio beacons, permitting radio leakage, dispatching probes for radio surveillance for dispatching vehicles for manned surveillance.

Multi-Modalities Sensor Science

DTIC Science & Technology

2015-02-28

enhanced multi-mode sensor science. bio -sensing, cross-discipling, multi-physics, nano-technology sailing He +46-8790 8465 1 Final Report for SOARD Project...spectroscopy, nano-technology, biophotonics and multi-physics modeling to produce adaptable bio -nanostructure enhanced multi-mode sensor science. 1...adaptable bio -nanostructure enhanced multi-mode sensor science. The accomplishments includes 1) A General Method for Designing a Radome to Enhance

Reconceptualising Understandings of Texts, Readers and Contexts: One English Teacher's Response to Using Multimodal Texts and Interactive Whiteboards

ERIC Educational Resources Information Center

Kitson, Lisbeth

2011-01-01

The comprehension of multimodal texts is now a key concern with the release of the Australian National Curriculum for English (ACARA, 2010). However, the nature of multimodal texts, the diversity of readers in classrooms, and the complex technological environments through which multimodal texts are mediated, requires English teachers to reconsider…

Spinoff 2009

NASA Technical Reports Server (NTRS)

2009-01-01

Topics covered include: Image-Capture Devices Extend Medicine's Reach; Medical Devices Assess, Treat Balance Disorders; NASA Bioreactors Advance Disease Treatments; Robotics Algorithms Provide Nutritional Guidelines; "Anti-Gravity" Treadmills Speed Rehabilitation; Crew Management Processes Revitalize Patient Care; Hubble Systems Optimize Hospital Schedules; Web-based Programs Assess Cognitive Fitness; Electrolyte Concentrates Treat Dehydration; Tools Lighten Designs, Maintain Structural Integrity; Insulating Foams Save Money, Increase Safety; Polyimide Resins Resist Extreme Temperatures; Sensors Locate Radio Interference; Surface Operations Systems Improve Airport Efficiency; Nontoxic Resins Advance Aerospace Manufacturing; Sensors Provide Early Warning of Biological Threats; Robot Saves Soldier's Lives Overseas (MarcBot); Apollo-Era Life Raft Saves Hundreds of Sailors; Circuits Enhance Scientific Instruments and Safety Devices; Tough Textiles Protect Payloads and Public Safety Officers; Forecasting Tools Point to Fishing Hotspots; Air Purifiers Eliminate Pathogens, Preserve Food; Fabrics Protect Sensitive Skin from UV Rays; Phase Change Fabrics Control Temperature; Tiny Devices Project Sharp, Colorful Images; Star-Mapping Tools Enable Tracking of Endangered Animals; Nanofiber Filters Eliminate Contaminants; Modeling Innovations Advance Wind Energy Industry; Thermal Insulation Strips Conserve Energy; Satellite Respondent Buoys Identify Ocean Debris; Mobile Instruments Measure Atmospheric Pollutants; Cloud Imagers Offer New Details on Earth's Health; Antennas Lower Cost of Satellite Access; Feature Detection Systems Enhance Satellite Imagery; Chlorophyll Meters Aid Plant Nutrient Management; Telemetry Boards Interpret Rocket, Airplane Engine Data; Programs Automate Complex Operations Monitoring; Software Tools Streamline Project Management; Modeling Languages Refine Vehicle Design; Radio Relays Improve Wireless Products; Advanced Sensors Boost Optical Communication, Imaging; Tensile Fabrics Enhance Architecture Around the World; Robust Light Filters Support Powerful Imaging Devices; Thermoelectric Devices Cool, Power Electronics; Innovative Tools Advance Revolutionary Weld Technique; Methods Reduce Cost, Enhance Quality of Nanotubes; Gauging Systems Monitor Cryogenic Liquids; Voltage Sensors Monitor Harmful Static; and Compact Instruments Measure Heat Potential.

NASA's Advanced Communications Technology Satellite (ACTS)

NASA Technical Reports Server (NTRS)

Gedney, R. T.

1983-01-01

NASA recently restructured its Space Communications Program to emphasize the development of high risk communication technology useable in multiple frequency bands and to support a wide range of future communication needs. As part of this restructuring, the Advanced Communications Technology Satellite (ACTS) Project will develop and experimentally verify the technology associated with multiple fixed and scanning beam systems which will enable growth in communication satellite capacities and more effective utilization of the radio frequency spectrum. The ACTS requirements and operations as well as the technology significance for future systems are described.

Gravitational wave discovery and characterization of the binary neutron star inspiral GW170817

NASA Astrophysics Data System (ADS)

Littenberg, Tyson; LIGO Scientific Collaboration and Virgo Collaboration

2018-01-01

On August 17, 2017 the Advanced LIGO and Advanced Virgo gravitational-wave detectors observed a binary neutron star inspiral. The source, GW170817, was the closest, loudest, and best localized gravitational-wave observation to date and was part of the spectacular multi-messenger observing campaign including the associated gamma-ray burst, a transient counterpart discovered in the optical, and late-time X-ray and radio emission. This talk will overview the discovery of GW170817 and what has been learned about the source from the gravitational-wave observations.

An atlas-based multimodal registration method for 2D images with discrepancy structures.

PubMed

Lv, Wenchao; Chen, Houjin; Peng, Yahui; Li, Yanfeng; Li, Jupeng

2018-06-04

An atlas-based multimodal registration method for 2-dimension images with discrepancy structures was proposed in this paper. Atlas was utilized for complementing the discrepancy structure information in multimodal medical images. The scheme includes three steps: floating image to atlas registration, atlas to reference image registration, and field-based deformation. To evaluate the performance, a frame model, a brain model, and clinical images were employed in registration experiments. We measured the registration performance by the squared sum of intensity differences. Results indicate that this method is robust and performs better than the direct registration for multimodal images with discrepancy structures. We conclude that the proposed method is suitable for multimodal images with discrepancy structures. Graphical Abstract An Atlas-based multimodal registration method schematic diagram.

Teaching the Essential Role of Visualization in Preparing Instructions

ERIC Educational Resources Information Center

Penrose, John M.

2006-01-01

Instructions are an essential communication component of organizations, but even advanced students seldom admit any shortcomings in direction-writing. Whether printed material for customers on how to use a product (construct the children's play set, connect a DVD player to a home entertainment center, or program a car radio's stations), formal job…

Fermilab | Science | Particle Accelerators | Advanced Superconducting Test

Science.gov Websites

Accelerators for science and society Particle Physics 101 Science of matter, energy, space and time How Technology (FAST) Facility is America's only test bed for cutting-edge, record high-intensity particle beams in the United States as a particle beam research facility based on superconducting radio-frequency

Rural land mobile radio market assessment and satellite and terrestrial system concepts

NASA Technical Reports Server (NTRS)

Stevenson, S. M.; Provencher, C. E.

1984-01-01

Market potential exists; the nature of the market in terms of service needs, usage characteristics, service requirements, and forecasting the demand to the year 2000; alternative system cncepts that show promise in addressing the identified needs, in a cost effective manner; and advanced technology requirements associated with these concepts are considered.

An automatic lightning detection and photographic system

NASA Technical Reports Server (NTRS)

Wojtasinski, R. J.; Holley, L. D.; Gray, J. L.; Hoover, R. B.

1973-01-01

Conventional 35-mm camera is activated by an electronic signal every time lightning strikes in general vicinity. Electronic circuit detects lightning by means of antenna which picks up atmospheric radio disturbances. Camera is equipped with fish-eye lense, automatic shutter advance, and small 24-hour clock to indicate time when exposures are made.