Science.gov

Sample records for advanced powertrain research

  1. REVIEW ARTICLE: Emission measurement techniques for advanced powertrains

    NASA Astrophysics Data System (ADS)

    Adachi, Masayuki

    2000-10-01

    Recent developments in high-efficiency low-emission powertrains require the emission measurement technologies to be able to detect regulated and unregulated compounds with very high sensitivity and a fast response. For example, levels of a variety of nitrogen compounds and sulphur compounds should be analysed in real time in order to develop aftertreatment systems to decrease emission of NOx for the lean burning powertrains. Also, real-time information on the emission of particulate matter for the transient operation of diesel engines and direct injection gasoline engines is invaluable. The present paper reviews newly introduced instrumentation for such emission measurement that is demanded for the developments in advanced powertrain systems. They include Fourier transform infrared spectroscopy, mass spectrometry and fast response flame ionization detection. In addition, demands and applications of the fuel reformer developments for fuel cell electric vehicles are discussed. Besides the detection methodologies, sample handling techniques for the measurement of concentrations emitted from low emission vehicles for which the concentrations of the pollutants are significantly lower than the concentrations present in ambient air, are also described.

  2. Advanced Gas Turbine (AGT) powertrain system

    NASA Technical Reports Server (NTRS)

    Helms, H. E.; Kaufeld, J.; Kordes, R.

    1981-01-01

    A 74.5 kW(100 hp) advanced automotive gas turbine engine is described. A design iteration to improve the weight and production cost associated with the original concept is discussed. Major rig tests included 15 hours of compressor testing to 80% design speed and the results are presented. Approximately 150 hours of cold flow testing showed duct loss to be less than the design goal. Combustor test results are presented for initial checkout tests. Turbine design and rig fabrication is discussed. From a materials study of six methods to fabricate rotors, two have been selected for further effort. A discussion of all six methods is given.

  3. Vehicle Systems Integration Laboratory Accelerates Powertrain Development

    ScienceCinema

    None

    2016-07-12

    ORNL's Vehicle Systems Integration (VSI) Laboratory accelerates the pace of powertrain development by performing prototype research and characterization of advanced systems and hardware components. The VSI Lab is capable of accommodating a range of platforms from advanced light-duty vehicles to hybridized Class 8 powertrains with the goals of improving overall system efficiency and reducing emissions.

  4. Advanced Gas Turbine (AGT) powertrain system development for automotive applications

    NASA Technical Reports Server (NTRS)

    1982-01-01

    A gas turbine powertrain for automobiles with reduced fuel consumption and reduced environmental impact is investigated. The automotive gas turbine, when installed in an automobile (3000 pounds inertia weight), provides a CFDC fuel economy of 42.8 miles per gallon based on EPA test procedures and diesel No. 2 fuel. The AGT powered vehicle substantially gives the same overall vehicle driveability and performance as a comparable production vehicle powered by a conventional spark ignition powertrain system. The emissions are less than federal standards, and a variety of fuels can be used.

  5. Advanced Gas Turbine (AGT) powertrain system development for automotive applications

    NASA Technical Reports Server (NTRS)

    1981-01-01

    An automotive gas turbine powertrain system which, when installed in a 1985 production vehicle (3000 pounds inertia weight), is being developed with a CFDC fuel economy of 42.8 miles per gallon based on Environmental Protection Agency (EPA) test procedures and diesel No. 2 fuel. The AGT-powered vehicle shall give substantially the same overall vehicle driveability and performance as a comparable 1985 production vehicle powered by a conventional spark ignition powertrain system (baseline system). Gaseous emissions and particulate levels less than: NOx = 0.4 gm/mile, HC = 0.41 gm/mile, and CO = 3.4 gm/mile, and a total particulate of 0.2 gm/mile, using the same fuel as used for fuel economy measurements is expected, along with the ability to use a variety of alternate fuels.

  6. Advanced Gas Turbine (AGT) powertrain system initial development report

    NASA Astrophysics Data System (ADS)

    1980-08-01

    The powertrain consists of a single shaft regenerated gas turbine engine utilizing ceramic hot section components, coupled to a slit differential gearbox with an available variable stator torque converter and an available Ford intergral overdrive four-speed automatic transmission. Predicted fuel economy using gasoline fuel over the combined federal driving cycle (CFDC) is 15.3 km/1, which represents a 59% improvement over the spark-ignition-powered baseline vehicle. Using DF2 fuel, CFDC mileage estimates are 17.43 km/1. Zero to 96.6 km/hr acceleration time is 11.9 seconds with a four-second accleration distance of 21.0 m. The ceramic radial turbine rotor is discussed along with the control system for the powertrain.

  7. Advanced Gas Turbine (AGT) powertrain system development for automotive applications

    NASA Technical Reports Server (NTRS)

    1980-01-01

    Progress in the development of a gas turbine engine to improve fuel economy, reduce gaseous emissions and particulate levels, and compatible with a variety of alternate fuels is reported. The powertrain is designated AGT101 and consists of a regenerated single shaft gas turbine engine, a split differential gearbox and a Ford Automatic Overdrive production transmission. The powertrain is controlled by an electronic digital microprocessor and associated actuators, instrumentation, and sensors. Standard automotive accessories are driven by engine power provided by an accessory pad on the gearbox. Component/subsystem development progress is reported in the following areas: compressor, turbine, combustion system, regenerator, gearbox/transmission, structures, ceramic components, foil gas bearing, bearings and seals, rotor dynamics, and controls and accessories.

  8. Advanced Gas Turbine (AGT) powertrain system initial development report

    NASA Technical Reports Server (NTRS)

    1980-01-01

    The powertrain consists of a single shaft regenerated gas turbine engine utilizing ceramic hot section components, coupled to a slit differential gearbox with an available variable stator torque converter and an available Ford intergral overdrive four-speed automatic transmission. Predicted fuel economy using gasoline fuel over the combined federal driving cycle (CFDC) is 15.3 km/1, which represents a 59% improvement over the spark-ignition-powered baseline vehicle. Using DF2 fuel, CFDC mileage estimates are 17.43 km/1. Zero to 96.6 km/hr acceleration time is 11.9 seconds with a four-second accleration distance of 21.0 m. The ceramic radial turbine rotor is discussed along with the control system for the powertrain.

  9. Advanced Gas Turbine (AGT) power-train system development

    NASA Technical Reports Server (NTRS)

    Helms, H. E.; Johnson, R. A.; Gibson, R. K.

    1982-01-01

    Technical work on the design and component testing of a 74.5 kW (100 hp) advanced automotive gas turbine is described. Selected component ceramic component design, and procurement were tested. Compressor tests of a modified rotor showed high speed performance improvement over previous rotor designs; efficiency improved by 2.5%, corrected flow by 4.6%, and pressure ratio by 11.6% at 100% speed. The aerodynamic design is completed for both the gasifier and power turbines. Ceramic (silicon carbide) gasifier rotors were spin tested to failure. Improving strengths is indicated by burst speeds and the group of five rotors failed at speeds between 104% and 116% of engine rated speed. The emission results from combustor testing showed NOx levels to be nearly one order of magnitude lower than with previous designs. A one piece ceramic exhaust duct/regenerator seal platform is designed with acceptable low stress levels.

  10. Advanced Gas Turbine (AGT) powertrain system development for automotive applications

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Preliminary layouts were made for the exhaust system, air induction system, and battery installation. Points of interference were identified and resolved by altering either the vehicle or engine designs. An engine general arrangement evolved to meet the vehicle engine compartment constraints while minimizing the duct pressure losses and the heat rejection. A power transfer system (between gasifier and power turbines) was developed to maintain nearly constant temperatures throughout the entire range of engine operation. An advanced four speed automatic transmission was selected to be used with the engine. Performance calculations show improvements in component efficiencies and an increase in fuel economy. A single stage centrifugal compressor design was completed and released for procurement. Gasifier turbine, power turbine, combustor, generator, secondary systems, materials, controls, and transmission development are reported.

  11. Powertrain Materials: The Road to Higher Efficiencies

    SciTech Connect

    2016-05-05

    Advanced powertrain materials are critical for automakers to meet new fuel economy standards. Researchers at the Department of Energy’s Oak Ridge National Laboratory are working with industry to develop new propulsion materials that offer improved performance at lower costs.

  12. Powertrain Materials: The Road to Higher Efficiencies

    ScienceCinema

    None

    2016-10-19

    Advanced powertrain materials are critical for automakers to meet new fuel economy standards. Researchers at the Department of Energy’s Oak Ridge National Laboratory are working with industry to develop new propulsion materials that offer improved performance at lower costs.

  13. Development of a range-extended electric vehicle powertrain for an integrated energy systems research printed utility vehicle

    DOE PAGES

    Chambon, Paul; Curran, Scott; Huff, Shean; ...

    2017-01-29

    Rapid vehicle and powertrain development has become essential to for the design and implementation of vehicles that meet and exceed the fuel efficiency, cost, and performance targets expected by today’s consumer while keeping pace with reduced development cycle and more frequent product releases. Advances in large-scale additive manufacturing have provided the means to bridge hardware-in-the-loop (HIL) experimentation and preproduction mule chassis evaluation, recently. Our paper details the accelerated development of a printed range-extended electric vehicle (REEV) by Oak Ridge National Laboratory, by paralleling hardware-in-the-loop development of the powertrain with rapid chassis prototyping using big area additive manufacturing (BAAM). BAAM’s abilitymore » to accelerate the mule vehicle development from computer-aided design to vehicle build is explored. The use of a hardware-in-the-loop laboratory is described as it is applied to the design of a range-extended electric powertrain to be installed in a printed prototype vehicle. Furthermore, the integration of the powertrain and the opportunities and challenges it presents are described in this work. A comparison of offline simulation, HIL and chassis rolls results is presented to validate the development process. Chassis dynamometer results for battery electric and range extender operation are analyzed to show the benefits of the architecture.« less

  14. SLH Timing Belt Powertrain

    SciTech Connect

    Schneider, Abe

    2014-04-09

    The main goal of this proposal was to develop and test a novel powertrain solution for the SLH hydroEngine, a low-cost, efficient low-head hydropower technology. Nearly two-thirds of U.S. renewable electricity is produced by hydropower (EIA 2010). According to the U.S. Department of Energy; this amount could be increased by 50% with small hydropower plants, often using already-existing dams (Hall 2004). There are more than 80,000 existing dams, and of these, less than 4% generate power (Blankinship 2009). In addition, there are over 800 irrigation districts in the U.S., many with multiple, non-power, low-head drops. These existing, non-power dams and irrigation drops could be retrofitted to produce distributed, baseload, renewable energy with appropriate technology. The problem is that most existing dams are low-head, or less than 30 feet in height (Ragon 2009). Only about 2% of the available low-head hydropower resource in the U.S. has been developed, leaving more than 70 GW of annual mean potential low-head capacity untapped (Hall 2004). Natel Energy, Inc. is developing a low-head hydropower turbine that operates efficiently at heads less than 6 meters and is cost-effective for deployment across multiple low-head structures. Because of the unique racetrack-like path taken by the prime-movers in the SLH, a flexible powertrain is required. Historically, the only viable technological solution was roller chain. Despite the having the ability to easily attach blades, roller chain is characterized by significant drawbacks, including high cost, wear, and vibration from chordal action. Advanced carbon- fiber-reinforced timing belts have been recently developed which, coupled with a novel belt attachment system developed by Natel Energy, result in a large reduction in moving parts, reduced mass and cost, and elimination of chordal action for increased fatigue life. The work done in this project affirmatively addressed each of the following 3 major uncertainties concerning

  15. Optimally Controlled Flexible Fuel Powertrain System

    SciTech Connect

    Duncan Sheppard; Bruce Woodrow; Paul Kilmurray; Simon Thwaite

    2011-06-30

    A multi phase program was undertaken with the stated goal of using advanced design and development tools to create a unique combination of existing technologies to create a powertrain system specification that allowed minimal increase of volumetric fuel consumption when operating on E85 relative to gasoline. Although on an energy basis gasoline / ethanol blends typically return similar fuel economy to straight gasoline, because of its lower energy density (gasoline ~ 31.8MJ/l and ethanol ~ 21.1MJ/l) the volume based fuel economy of gasoline / ethanol blends are typically considerably worse. This project was able to define an initial engine specification envelope, develop specific hardware for the application, and test that hardware in both single and multi-cylinder test engines to verify the ability of the specified powertrain to deliver reduced E85 fuel consumption. Finally, the results from the engine testing were used in a vehicle drive cycle analysis tool to define a final vehicle level fuel economy result. During the course of the project, it was identified that the technologies utilized to improve fuel economy on E85 also enabled improved fuel economy when operating on gasoline. However, the E85 fueled powertrain provided improved vehicle performance when compared to the gasoline fueled powertrain due to the improved high load performance of the E85 fuel. Relative to the baseline comparator engine and considering current market fuels, the volumetric fuel consumption penalty when running on E85 with the fully optimized project powertrain specification was reduced significantly. This result shows that alternative fuels can be utilized in high percentages while maintaining or improving vehicle performance and with minimal or positive impact on total cost of ownership to the end consumer. The justification for this project was two-fold. In order to reduce the US dependence on crude oil, much of which is imported, the US Environmental Protection Agency (EPA

  16. Research Advances

    ERIC Educational Resources Information Center

    King, Angela G.

    2004-01-01

    Research advances, a new feature in Journal of Chemical Engineering that brings information about innovations in current areas of research to high school and college science faculty with an intent to provide educators with timely descriptions of latest progress in research that can be integrated into existing courses to update course content and…

  17. Predictive powertrain control using powertrain history and GPS data

    DOEpatents

    Weslati, Feisel; Krupadanam, Ashish A

    2015-03-03

    A method and powertrain apparatus that predicts a route of travel for a vehicle and uses historical powertrain loads and speeds for the predicted route of travel to optimize at least one powertrain operation for the vehicle.

  18. Advanced Gas Turbine (AGT) powertrain system development for automotive applications report

    NASA Technical Reports Server (NTRS)

    1984-01-01

    This report describes progress and work performed during January through June 1984 to develop technology for an Advanced Gas Turbine (AGT) engine for automotive applications. Work performed during the first eight periods initiated design and analysis, ceramic development, component testing, and test bed evaluation. Project effort conducted under this contract is part of the DOE Gas Turbine Highway Vehicle System Program. This program is oriented at providing the United States automotive industry the high-risk long-range techology necessary to produce gas turbine engines for automobiles with reduced fuel consumption and reduced environmental impact. Technology resulting from this program is intended to reach the marketplace by the early 1990s.

  19. Hybrid powertrain controller

    DOEpatents

    Jankovic, Miroslava; Powell, Barry Kay

    2000-12-26

    A hybrid powertrain for a vehicle comprising a diesel engine and an electric motor in a parallel arrangement with a multiple ratio transmission located on the torque output side of the diesel engine, final drive gearing connecting drivably the output shaft of transmission to traction wheels of the vehicle, and an electric motor drivably coupled to the final drive gearing. A powertrain controller schedules fuel delivered to the diesel engine and effects a split of the total power available, a portion of the power being delivered by the diesel and the balance of the power being delivered by the motor. A shifting schedule for the multiple ratio transmission makes it possible for establishing a proportional relationship between accelerator pedal movement and torque desired at the wheels. The control strategy for the powertrain maintains drivability of the vehicle that resembles drivability of a conventional spark ignition vehicle engine powertrain while achieving improved fuel efficiency and low exhaust gas emissions.

  20. Research Advances

    ERIC Educational Resources Information Center

    King, Angela G.

    2005-01-01

    Researchers in the Department of Bioengineering at Rice University are developing a new approach for fighting cancer, based on nanoshells that can both detect and destroy cancerous cells. The aim is to locate the cells, and be able to make a rational choice about whether they need to be destroyed and if possible they should immediately be sent for…

  1. Research Advances

    ERIC Educational Resources Information Center

    King, Angela G.

    2004-01-01

    Nanotechnology are employed by researchers at Northwestern University to develop a method of labeling disease markers present in blood with unique DNA tags they have dubbed "bio-bar-codes". The preparation of nanoparticle and magnetic microparticle probes and a nanoparticle-based PSR-less DNA amplification scheme are involved by the DNA-BCA assay.

  2. Hybrid powertrain system

    DOEpatents

    Hughes, Douglas A.

    2006-08-01

    A powertrain system is provided that includes a first prime mover and change-gear transmission having a first input shaft and a second input shaft. A twin clutch is disposed between the first prime mover and the transmission. The twin clutch includes a first main clutch positioned between the first prime mover and the first input shaft and a second main clutch positioned between the first prime mover and the second input shaft. The powertrain system also includes a second prime mover operably connected to one of the first and second input shafts.

  3. Hybrid powertrain system

    DOEpatents

    Hughes, Douglas A.

    2007-09-25

    A powertrain system is provided that includes a first prime mover and change-gear transmission having a first input shaft and a second input shaft. A twin clutch is disposed between the first prime mover and the transmission. The twin clutch includes a first main clutch positioned between the first prime mover and the first input shaft and a second main clutch positioned between the first prime mover and the second input shaft. The powertrain system also includes a second prime mover operably connected to one of the first and second input shafts.

  4. The $2000 Electric Powertrain Option-1 Program. Final technical report

    SciTech Connect

    1999-06-01

    This report describes the tasks accomplished as part of Northrop Grumman's TRP $2000 Electric Powertrain Option-1 program. Northrop Grumman has strived to achieve technology advances and development considered as high priority to the success of future electric vehicles. Northrop Grumman has achieved the intent of the program by taking several steps toward reducing the cost of the electric vehicle powertrain, demonstrating technologies in the form of hardware and introducing enhancements into production that are consistent with the needs of the market.

  5. Powertrain Controls Optimization for HD Hybrid Line Haul Trucks - FY2014 Annual Report

    SciTech Connect

    Smith, David E.

    2014-12-01

    This is a vehicle system level project, encompassing analytical modeling and supervisory controls development as well as experimental verification/validation testing at the component, powertrain, and full vehicle system level. This project supports the goal of petroleum consumption reduction for medium and heavy trucks through the development of advanced hybrid technologies and control systems. VSST has invested previously in R&D to support hybrid energy storage systems (Li-ion plus ultra-caps) for light duty, passenger car applications. This research will be extended to the MD and HD sector where current battery technology is not mature enough to handle the substantial regenerative braking power levels these trucks are capable of producing. With this hybrid energy storage system, substantial gains in overall vehicle efficiency are possible. In addition, advanced combustion technologies, such as RCCI, will be implemented into an advanced hybrid powertrain for a Class 8 line haul application. This powertrain, leveraged from other VSST work (Meritor, a current ORNL/VSST partner), is ideal for taking advantage of the benefits of RCCI operation due to its series hybrid mode of operation. Emissions control is also a focus of this project, especially due to the fact that RCCI creates a low temperature exhaust stream that must addressed.

  6. Assessment of US electric vehicle programs with ac powertrains

    SciTech Connect

    Kevala, R.J. . Transportation Consulting Div.)

    1990-02-01

    AC powertrain technology is a promising approach to improving the performance of electric vehicles. Four major programs are now under way in the United States to develop ac powertrains: the Ford/General Electric single-shaft electric propulsion system (ETX-II), the Eaton dual-shaft electric propulsion system (DSEP), the Jet Propulsion Laboratories (JPL) integrated ac motor drive and recharge system, and the Massachusetts Institute of Technology (MIT) variable reluctance motor (VRM) drive. The JPL program is sponsored by EPRI; the other three programs are funded by the US Department of Energy. This preliminary assessment of the four powertrain programs focuses on potential performance, costs, safety, and commercial feasibility. Interviews with program personnel were supplemented by computer simulations of electric vehicle performance using the four systems. Each of the four powertrains appears superior to standard dc powertrain technology in terms of performance and weight. The powertrain technologies studied in this assessment are at varying degrees of technological maturity. One or more of the systems may be ready for incorporation into an advanced electric vehicle during the early 1990s. Each individual report will have a separate abstract. 5 refs., 37 figs., 29 tabs.

  7. Advancing Ethical Neuroscience Research.

    PubMed

    Borah, B Rashmi; Strand, Nicolle K; Chillag, Kata L

    2016-12-01

    As neuroscience research advances, researchers, clinicians, and other stakeholders will face a host of ethical challenges. The Presidential Commission for the Study of Bioethical Issues (Bioethics Commission) has published two reports that provide recommendations on how to advance research endeavors ethically. The commission addressed, among other issues, how to prioritize different types of neuroscience research and how to include research participants who have impaired consent capacity. The Bioethics Commission's recommendations provide a foundation for ethical guidelines as neuroscience research advances and progresses.

  8. Austempered Materials for Powertrain Applications

    NASA Astrophysics Data System (ADS)

    Lefevre, Justin; Hayrynen, Kathy L.

    2013-07-01

    Austempered irons and steels offer the design engineer alternatives to conventional material/process combinations. Depending on the material and the application, Austempering may provide the following benefits to producers of powertrain components such as gears and shafts: ease of manufacturing, increased bending and/or contact fatigue strength, better wear resistance and enhanced dampening characteristics resulting in lower noise. Austempered materials have been used to improve the performance of powertrain components in numerous applications for a wide range of industries, from gears and shafts to clutch plates and crankshafts. This paper focuses on Austempered solutions for powertrain applications with an emphasis on gear and shaft solutions.

  9. Hybrid powertrain system

    SciTech Connect

    Grillo, Ricardo C.; O'Neil, Walter K.; Preston, David M.

    2005-09-20

    A hybrid powertrain system is provided that includes a first prime mover having a rotational output, a second prime mover having a rotational output, and a transmission having a main shaft supporting at least two main shaft gears thereon. The transmission includes a first independent countershaft drivingly connected to the first prime mover and including at least one ratio gear supported thereon that meshes with a respective main shaft gear. A second independent countershaft is drivingly connected to the second prime mover and includes at least one ratio gear supported thereon that meshes with a respective main shaft gear. The ratio gears on the first and second countershafts cooperate with the main shaft gears to provide at least one gear ratio between the first and second countershafts and the main shaft. A shift control mechanism selectively engages and disengages the first and second countershafts for rotation with the main shaft.

  10. Advances in Qualitative Research.

    ERIC Educational Resources Information Center

    1998

    This document contains five papers from a symposium on advances in qualitative research in human resource development (HRD). "Case Study and Its Virtuoso Possibilities" (Verna J. Willis) asserts that the case study method is particularly well suited for research in HRD because its creative and investigative possibilities have not yet…

  11. Power requirements for PHERB powertrain

    NASA Astrophysics Data System (ADS)

    Norbakyah, J. S.; Atiq, W. H.; Salisa, A. R.

    2015-12-01

    Boats are considered as favourite maritime transportation designed for recreation activities, fishing and surveillance purposes. However, in tropical developed countries, boats are employed for different applications such as passenger and goods transportation. In this paper, the power requirements for a proposed plug-in hybrid electric recreational boat (PHERB) powertrain is determined using a steady state velocity and the Kuala Terengganu river driving cycle according to the boat parameters, specifications and performance requirements. The boat power requirements can be used to size the main components for PHERB powertrain. The results obtained from this analysis are within reasonable range and satisfactory.

  12. NASA Advanced Propeller Research

    NASA Technical Reports Server (NTRS)

    Groeneweg, John F.; Bober, Lawrence J.

    1988-01-01

    Acoustic and aerodynamic research at NASA Lewis Research Center on advanced propellers is reviewed including analytical and experimental results on both single and counterrotation. Computational tools used to calculate the detailed flow and acoustic i e l d s a r e described along with wind tunnel tests to obtain data for code verification . Results from two kinds of experiments are reviewed: ( 1 ) performance and near field noise at cruise conditions as measured in the NASA Lewis 8-by 6-Foot Wind Tunnel and ( 2 ) farfield noise and performance for takeoff/approach conditions as measured in the NASA Lewis 9-by 15-Font Anechoic Wind Tunnel. Detailed measurements of steady blade surface pressures are described along with vortex flow phenomena at off design conditions . Near field noise at cruise is shown to level out or decrease as tip relative Mach number is increased beyond 1.15. Counterrotation interaction noise is shown to be a dominant source at take off but a secondary source at cruise. Effects of unequal rotor diameters and rotor-to-rotor spacing on interaction noise a real so illustrated. Comparisons of wind tunnel acoustic measurements to flight results are made. Finally, some future directions in advanced propeller research such as swirl recovery vanes, higher sweep, forward sweep, and ducted propellers are discussed.

  13. NASA advanced propeller research

    NASA Technical Reports Server (NTRS)

    Groeneweg, John F.; Bober, Lawrence J.

    1988-01-01

    Acoustic and aerodynamic research at NASA Lewis Research Center on advanced propellers is reviewed including analytical and experimental results on both single and counterrotation. Computational tools used to calculate the detailed flow and acoustic fields are described along with wind tunnel tests to obtain data for code verification. Results from two kinds of experiments are reviewed: (1) performance and near field noise at cruise conditions as measured in the NASA Lewis 8- by 6-foot Wind Tunnel; and (2) far field noise and performance for takeoff/approach conditions as measured in the NASA Lewis 9- by 15-foot Anechoic Wind Tunnel. Detailed measurements of steady blade surface pressures are described along with vortex flow phenomena at off-design conditions. Near field noise at cruise is shown to level out or decrease as tip relative Mach number is increased beyond 1.15. Counterrotation interaction noise is shown to be a dominant source at takeoff but a secondary source at cruise. Effects of unequal rotor diameters and rotor-to-rotor spacing on interaction noise are also illustrated. Comparisons of wind tunnel acoustic measurements to flight results are made. Finally, some future directions in advanced propeller research such as swirl recovery vanes, higher sweep, forward sweep, and ducted propellers are discussed.

  14. Method for controlling powertrain pumps

    DOEpatents

    Sime, Karl Andrew; Spohn, Brian L; Demirovic, Besim; Martini, Ryan D; Miller, Jean Marie

    2013-10-22

    A method of controlling a pump supplying a fluid to a transmission includes sensing a requested power and an excess power for a powertrain. The requested power substantially meets the needs of the powertrain, while the excess power is not part of the requested power. The method includes sensing a triggering condition in response to the ability to convert the excess power into heat in the transmission, and determining that an operating temperature of the transmission is below a maximum. The method also includes determining a calibrated baseline and a dissipation command for the pump. The calibrated baseline command is configured to supply the fluid based upon the requested power, and the dissipation command is configured to supply additional fluid and consume the excess power with the pump. The method operates the pump at a combined command, which is equal to the calibrated baseline command plus the dissipation command.

  15. Advanced propeller research

    NASA Technical Reports Server (NTRS)

    Groeneweg, John F.; Bober, Lawrence J.

    1987-01-01

    Resent results of aerodynamic and acoustic research on both single and counter-rotation propellers are reviewed. Data and analytical results are presented for three propellers: SR-7A, the single rotation design used in the NASA Propfan Test Assessment (PTA); and F7-A7, the 8+8 counterrotating design used in the proof-of-concept Unducted Fan (UDF) engine. In addition to propeller efficiencies, cruise and takeoff noise, and blade pressure data, off-design phenomena involving formation of leading edge vortices are described. Aerodynamic and acoustic computational results derived from three-dimensional Euler and acoustic radiation codes are presented. Research on unsteady flows, which are particularly important for understanding counterrotation interaction noise, unsteady loading effects on acoustics, and flutter or forced response is described. The first results of three-dimensional unsteady Euler solutions are illustrated for a single rotation propeller at an angle of attack and for a counterrotation propeller. Basic experimental and theoretical results from studies of the unsteady aerodynamics of oscillating cascades are outlined. Finally, advanced concepts involving swirl recovery vanes and ultra bypass ducted propellers are discussed.

  16. Conceptual design study of an improved automotive gas turbine powertrain

    NASA Technical Reports Server (NTRS)

    Wagner, C. E. (Editor); Pampreen, R. C. (Editor)

    1979-01-01

    Automotive gas turbine concepts with significant technological advantages over the spark ignition (SI) engine were assessed. Possible design concepts were rated with respect to fuel economy and near-term application. A program plan which outlines the development of the improved gas turbine (IGT) concept that best met the goals and objectives of the study identifies the research and development work needed to meet the goal of entering a production engineering phase by 1983. The fuel economy goal is to show at least a 20% improvement over a conventional 1976 SI engine/vehicle system. On the basis of achieving the fuel economy goal, of overall suitability to mechanical design, and of automotive mass production cost, the powertrain selected was a single-shaft engine with a radial turbine and a continuously variable transmission (CVT). Design turbine inlet temperature was 1150 C. Reflecting near-term technology, the turbine rotor would be made of an advanced superalloy, and the transmission would be a hydromechanical CVT. With successful progress in long-lead R&D in ceramic technology and the belt-drive CVT, the turbine inlet temperature would be 1350 C to achieve near-maximum fuel economy.

  17. Conceptual design study of improved automotives gas turbine powertrain

    NASA Technical Reports Server (NTRS)

    1979-01-01

    Twenty-two candidate engine concepts and nineteen transmission concepts. Screening of these concepts, predominantly for fuel economy, cost and technical risk, resulted in a recommended powertrain consisting of a single-shaft engine, with a ceramic radial turbine rotor, connected through a differential split-power transmission utilizing a variable stator torque converter and a four speed automatic gearbox. Vehicle fuel economy and performance projections, preliminary design analyses and installation studies in a were completed. A cost comparison with the conventional spark ignited gasoline engine showed that the turbine engine would be more expensive initially, however, lifetime cost of ownership is in favor of the gas turbine. A powertrain research and development plan was constructed to gain information on timing and costs to achieve the required level of technology and demonstrate the engine in a vehicle by the year 1983.

  18. Advancing Scientific Research in Education

    ERIC Educational Resources Information Center

    Towne, Lisa, Ed.; Wise, Lauress L., Ed.; Winters, Tina M., Ed.

    2005-01-01

    The title of this report reveals its purpose precisely: to spur actions that will advance scientific research in education. The recommendations for accomplishing this goal, detailed in this report, build on the National Research Council (NRC) report "Scientific Research in Education" (National Research Council, 2002). That report offers an…

  19. [Research advances in dendrochronology].

    PubMed

    Fang, Ke-Yan; Chen, Qiu-Yan; Liu, Chang-Zhi; Cao, Chun-Fu; Chen, Ya-Jun; Zhou, Fei-Fei

    2014-07-01

    Tree-ring studies in China have achieved great advances since the 1990s, particularly for the dendroclimatological studies which have made some influence around the world. However, because of the uneven development, limited attention has been currently paid on the other branches of dendrochronology. We herein briefly compared the advances of dendrochronology in China and of the world and presented suggestions on future dendrochronological studies. Large-scale tree-ring based climate reconstructions in China are highly needed by employing mathematical methods and a high quality tree-ring network of the ring-width, density, stable isotope and wood anatomy. Tree-ring based field climate reconstructions provide potentials on explorations of climate forcings during the reconstructed periods via climate diagnosis and process simulation.

  20. Advances in lightning research

    NASA Astrophysics Data System (ADS)

    Cooray, Vernon; Rachidi, Farhad

    2017-02-01

    This is the part II of a special issue dedicated to lightning research, consisting of papers presented at the 32nd International Conference on Lightning Protection (ICLP), held in Shanghai, China, in 2014, and several contributions invited by the guest editors to complement the subject matter of the papers selected from the ICLP. The papers from the ICLP were selected by the session chairmen of the ICLP and passed through the rigorous review process of the Journal of Solar Terrestrial and Atmospheric Physics (JASTP). The papers presented in this special issue contain subject matter pertinent to all aspects of lightning research both theoretical and experimental.

  1. Advances in Electrophysiological Research

    PubMed Central

    Kamarajan, Chella; Porjesz, Bernice

    2015-01-01

    Electrophysiological measures of brain function are effective tools to understand neurocognitive phenomena and sensitive indicators of pathophysiological processes associated with various clinical conditions, including alcoholism. Individuals with alcohol use disorder (AUD) and their high-risk offspring have consistently shown dysfunction in several electrophysiological measures in resting state (i.e., electroencephalogram) and during cognitive tasks (i.e., event-related potentials and event-related oscillations). Researchers have recently developed sophisticated signal-processing techniques to characterize different aspects of brain dynamics, which can aid in identifying the neural mechanisms underlying alcoholism and other related complex disorders. These quantitative measures of brain function also have been successfully used as endophenotypes to identify and help understand genes associated with AUD and related disorders. Translational research also is examining how brain electrophysiological measures potentially can be applied to diagnosis, prevention, and treatment. PMID:26259089

  2. ADVANCED GAS TURBINE SYSTEMS RESEARCH

    SciTech Connect

    Unknown

    2000-01-01

    The activities of the Advanced Gas Turbine Systems Research (AGRSR) program are described in the quarterly report. The report is divided into discussions of Membership, Administration, Technology Transfer (Workshop/Education) and Research. Items worthy of note are presented in extended bullet format following the appropriate heading.

  3. ADVANCED GAS TURBINE SYSTEMS RESEARCH

    SciTech Connect

    Unknown

    2002-02-01

    The activities of the Advanced Gas Turbine Systems Research (AGTSR) program for this reporting period are described in this quarterly report. The report is divided into discussions of Membership, Administration, Technology Transfer (Workshop/Education), Research and Miscellaneous Related Activity. Items worthy of note are presented in extended bullet format following the appropriate heading.

  4. ADVANCED GAS TURBINE SYSTEMS RESEARCH

    SciTech Connect

    Unknown

    2002-04-01

    The activities of the Advanced Gas Turbine Systems Research (AGTSR) program for this reporting period are described in this quarterly report. The report is divided into discussions of Membership, Administration, Technology Transfer (Workshop/Education), Research and Miscellaneous Related Activity. Items worthy of note are presented in extended bullet format following the appropriate heading.

  5. Advanced Current Collection Research

    DTIC Science & Technology

    1977-05-01

    Research Projects Agency SContract N00014-76-C-0683 ARPA Order No. 3153 SC. J. Mole, D. L. Greene, I. R. McNab, J. L. Johnson, 0. S. Taylor, W. R. Gass ... Gass , W.R. 6. REPORT DATE 70 TOTAL NO OP PAGES 7b NO OF REFS May 1977 901 fan. CONTRACT OR GRANT No. 9a. ORIGINATOR’S REPORT NUMBER(S) N00014-76-C-0683...considerations In the shunt design. In order for the solid brush to move radially in and out of the brush holder with rotor movement, the shunt-to-brush

  6. Advanced Remote Sensing Research

    USGS Publications Warehouse

    Slonecker, Terrence; Jones, John W.; Price, Susan D.; Hogan, Dianna

    2008-01-01

    'Remote sensing' is a generic term for monitoring techniques that collect information without being in physical contact with the object of study. Overhead imagery from aircraft and satellite sensors provides the most common form of remotely sensed data and records the interaction of electromagnetic energy (usually visible light) with matter, such as the Earth's surface. Remotely sensed data are fundamental to geographic science. The Eastern Geographic Science Center (EGSC) of the U.S. Geological Survey (USGS) is currently conducting and promoting the research and development of three different aspects of remote sensing science: spectral analysis, automated orthorectification of historical imagery, and long wave infrared (LWIR) polarimetric imagery (PI).

  7. Advanced propeller research

    NASA Technical Reports Server (NTRS)

    Groeneweg, John F.; Bober, Lawrence J.

    1990-01-01

    Recent results of aerodynamic and acoustic research on both single rotation and counterrotation propellers are reviewed. Data and analytical results are presented for three propellers: SR-7A, the single rotation design used in the NASA Propfan Test Assessment (PTA) flight program; CRP-X1, the initial 5+5 Hamilton Standard counterrotating design; and F7-A7, the 8+8 counterrotating G.E. design used in the proof of concept Unducted Fan (UDF) engine. In addition to propeller efficiencies, cruise and takeoff noise, and blade pressure data, off-design phenomena involving formation of leading edge vortexes are described. Aerodynamic and acoustic computational results derived from 3-D Euler and acoustic radiation codes are presented. Research on unsteady flows which are particularly important for understanding counterrotation interaction noise, unsteady loading effects on acoustics, and flutter or forced response is described. The first results of 3-D unsteady Euler solutions are illustrated for a single rotation propeller at angle of attack and for a counterrotation propeller. Basic experimental and theoretical results from studies on the unsteady aerodynamics of oscillating cascades are outlined.

  8. Advanced ion thruster research

    NASA Technical Reports Server (NTRS)

    Wilbur, P. J.

    1984-01-01

    A simple model describing the discharge chamber performance of high strength, cusped magnetic field ion thrusters is developed. The model is formulated in terms of the energy cost of producing ions in the discharge chamber and the fraction of ions produced in the discharge chamber that are extracted to form the ion beam. The accuracy of the model is verified experimentally in a series of tests wherein the discharge voltage, propellant, grid transparency to neutral atoms, beam diameter and discharge chamber wall temperature are varied. The model is exercised to demonstrate what variations in performance might be expected by varying discharge chamber parameters. The results of a study of xenon and argon orificed hollow cathodes are reported. These results suggest that a hollow cathode model developed from research conducted on mercury cathodes can also be applied to xenon and argon. Primary electron mean free paths observed in argon and xenon cathodes that are larger than those found in mercury cathodes are identified as a cause of performance differences between mercury and inert gas cathodes. Data required as inputs to the inert gas cathode model are presented so it can be used as an aid in cathode design.

  9. Superconductors (History & Advanced Research)

    NASA Astrophysics Data System (ADS)

    Khorrami, Mona

    2012-02-01

    Superconductors are materials that have no resistance to electricity's flow; they are one of the last great frontiers of scientific discovery. In 1911 superconductivity was first observed in mercury by Dutch physicist Heike Kamerlingh Onnes When he cooled it to the temperature of liquid helium, 4 degrees Kelvin (-452F, -269C), its resistance suddenly disappeared. It was necessary for Onnes to come within 4 degrees of the coldest temperature that is theoretically attainable to witness the phenomenon of superconductivity. The next great milestone in understanding how matter behaves at extreme cold temperatures occurred in 1933. German researchers Walther Meissner and Robert Ochsenfeld discovered that a superconducting material will repel a magnetic field. A magnet moving by a conductor induces currents in the conductor. This is the principle on which the electric generator operates. But, in a superconductor the induced currents exactly mirror the field that would have otherwise penetrated the superconducting material - causing the magnet to be repulsed. This phenomenon is known as strong diamagnetism and is today often referred to as the ``Meissner effect'' (an eponym). In 1941 niobium-nitride was found to superconduct at 16 K. In 1953 vanadium-silicon displayed superconductive properties at 17.5 K. And, in 1962 scientists at Westinghouse developed the first commercial superconducting wire, an alloy of niobium and titanium (NbTi).

  10. Method of converting an existing vehicle powertrain to a hybrid powertrain system

    SciTech Connect

    Reed, Jr., Richard G.; Boberg, Evan S.; Lawrie, Robert E.; Castaing, Francois J.

    2001-12-25

    A method of converting an existing vehicle powertrain including a manual transmission to a hybrid powertrain system with an automated powertrain transmission. The first step in the method of attaching a gear train housing to a housing of said manual transmission, said gear train housing receiving as end of drive shaft of said transmission and rotatably supporting a gear train assembly. Secondly, mounting an electric motor/generator to said gear train housing and attaching a motor/generator drive shaft of said electric motor/generator to said gear train assembly. Lastly, connecting an electro-mechanical clutch actuator to a friction clutch mechanism of said manual transmission.

  11. Powertrain system for a hybrid electric vehicle

    DOEpatents

    Reed, R.G. Jr.; Boberg, E.S.; Lawrie, R.E.; Castaing, F.J.

    1999-08-31

    A hybrid electric powertrain system is provided including an electric motor/generator drivingly engaged with the drive shaft of a transmission. The electric is utilized for synchronizing the rotation of the drive shaft with the driven shaft during gear shift operations. In addition, a mild hybrid concept is provided which utilizes a smaller electric motor than typical hybrid powertrain systems. Because the electric motor is drivingly engaged with the drive shaft of the transmission, the electric motor/generator is driven at high speed even when the vehicle speed is low so that the electric motor/generator provides more efficient regeneration. 34 figs.

  12. Powertrain system for a hybrid electric vehicle

    DOEpatents

    Reed, Jr., Richard G.; Boberg, Evan S.; Lawrie, Robert E.; Castaing, Francois J.

    1999-08-31

    A hybrid electric powertrain system is provided including an electric motor/generator drivingly engaged with the drive shaft of a transmission. The electric is utilized for synchronizing the rotation of the drive shaft with the driven shaft during gear shift operations. In addition, a mild hybrid concept is provided which utilizes a smaller electric motor than typical hybrid powertrain systems. Because the electric motor is drivingly engaged with the drive shaft of the transmission, the electric motor/generator is driven at high speed even when the vehicle speed is low so that the electric motor/generator provides more efficient regeneration.

  13. ISAAC Advanced Composites Research Testbed

    NASA Technical Reports Server (NTRS)

    Wu, K. Chauncey; Stewart, Brian K.; Martin, Robert A.

    2014-01-01

    The NASA Langley Research Center is acquiring a state-of-art composites fabrication capability to support the Center's advanced research and technology mission. The system introduced in this paper is named ISAAC (Integrated Structural Assembly of Advanced Composites). The initial operational capability of ISAAC is automated fiber placement, built around a commercial system from Electroimpact, Inc. that consists of a multi-degree of freedom robot platform, a tool changer mechanism, and a purpose-built fiber placement end effector. Examples are presented of the advanced materials, structures, structural concepts, fabrication processes and technology development that may be enabled using the ISAAC system. The fiber placement end effector may be used directly or with appropriate modifications for these studies, or other end effectors with different capabilities may either be bought or developed with NASA's partners in industry and academia.

  14. Advanced aerodynamics. Selected NASA research

    NASA Technical Reports Server (NTRS)

    1981-01-01

    This Conference Publication contains selected NASA papers that were presented at the Fifth Annual Status Review of the NASA Aircraft Energy Efficiency (ACEE) Energy Efficient Transport (EET) Program held at Dryden Flight Research Center in Edwards, California on September 14 to 15, 1981. These papers describe the status of several NASA in-house research activities in the areas of advanced turboprops, natural laminar flow, oscillating control surfaces, high-Reynolds-number airfoil tests, high-lift technology, and theoretical design techniques.

  15. Advanced Information System Research Project.

    DTIC Science & Technology

    1980-06-01

    realistic near-term achievements. The research program objectives are to develop , manage , and coordinate activities relating to the following: o... development ; o Development and demonstration of tools, techniques, procedures, and advanced design concepts applicable to future management ... management is consolidated under the Division Property Book Officer. Property book accountability is maintained under the provisions of AR 735-35, and

  16. Advances in Teacher Effectiveness Research

    ERIC Educational Resources Information Center

    Brophy, Jere E.

    2010-01-01

    Classroom research on process-outcome relationships had burgeoned in recent years, revealing notable methodological advances and sensible, replicated findings. The studies of the early 1970s supporting direct instruction as particularly effective for producing achievement in basic skills in the early grades have been replicated and extended to…

  17. Advanced ac powertrain for electric vehicles

    SciTech Connect

    Slicker, J.M.; Kalns, L.

    1985-01-01

    The design of an ac propulsion system for an electric vehicle includes a three-phase induction motor, transistorized PWM inverter/battery charger, microprocessor-based controller, and two-speed automatic transaxle. This system was built and installed in a Mercury Lynx test bed vehicle as part of a Department of Energy propulsion system development program. An integral part of the inverter is a 4-kw battery charger which utilizes one of the bridge transistors. The overall inverter strategy for this configuration is discussed. The function of the microprocessor-based controller is described. Typical test results of the total vehicle and each of its major components are given, including system efficiencies and test track performance results.

  18. Gas Turbine Heavy Hybrid Powertrain Variants. Opportunities and Potential for Systems Optimization

    SciTech Connect

    Smith, David; Chambon, Paul H.

    2015-07-01

    Widespread use of alternative hybrid powertrains is currently inevitable, and many opportunities for substantial progress remain. Hybrid electric vehicles (HEVs) have attracted considerable attention due to their potential to reduce petroleum consumption and greenhouse gas emissions in the transportation sector. This capability is mainly attributed to (a) the potential for downsizing the engine, (b) the potential for recovering energy during braking and thus recharging the energy storage unit, and (c) the ability to minimize the operation of the engine outside of its most efficient brake specific fuel consumption (BSFC) regime. Hybridization of the Class 8, heavy-duty (HD) powertrain is inherently challenging due to the expected long-haul driving requirements and limited opportunities for regenerative braking. The objective of this project is to develop control strategies aiming at optimizing the operation of a Class 8 HEV that features a micro-turbine as the heat engine. The micro-turbine application shows promise in fuel efficiency, even when compared to current diesel engines, and can meet regulated exhaust emissions levels with no exhaust after-treatment system. Both parallel and series HEV variants will be examined to understand the merits of each approach of the micro-turbine to MD advanced powertrain applications. These powertrain configurations enable new paradigms in operational efficiency, particularly in the Class 8 truck fleet. The successful development of these HEV variants will require a thorough technical understanding of the complex interactions between various energy sources and energy consumption components, for various operating modes. PACCAR will be integrating the first generation of their series HEV powertrain with a Brayton Energy micro-turbine into a Class 8 HD truck tractor that has both regional haul and local pick-up and delivery (P&D) components to its drive cycle. The vehicle will be deployed into fleet operation for a demonstration

  19. Advancing neurosurgery through translational research.

    PubMed

    Lacey, Claire; Sutherland, Garnette

    2013-01-01

    Every year, the number of published research articles increases significantly. However, many potentially useful ideas are lost in this flood of data. Translational research provides a framework through which investigators or laboratories can maximize the likelihood that the product of their research will be adopted in medical practice. There are 2 recognizable models of translation appropriate for the majority of research: investigator driven and industry enabled. Investigator-driven research has more range because it does not have to consider the profit margin of research, but it is a slow process. The industry-enabled model accelerates the translational research process through the power of industry funding but is interested primarily in products with potential for profit. Two cases are examined to illustrate different methods of partnering with industry. IMRIS is a company founded by investigators to distribute intraoperative magnetic resonance imaging technology based on a movable high-field magnet. It took 7 years for IMRIS to make its first sale, but it is now a successful company. With neuroArm, a surgical robot, investigators decided to sell the intellectual property to an established company to ensure successful global commercialization. Translational research advances medicine by creating and distributing effective solutions to contemporary problems.

  20. Powertrain Test Procedure Development for EPA GHG Certification of Medium- and Heavy-Duty Engines and Vehicles

    SciTech Connect

    Chambon, Paul H.; Deter, Dean D.

    2016-07-01

    xiii ABSTRACT The goal of this project is to develop and evaluate powertrain test procedures that can accurately simulate real-world operating conditions, and to determine greenhouse gas (GHG) emissions of advanced medium- and heavy-duty engine and vehicle technologies. ORNL used their Vehicle System Integration Laboratory to evaluate test procedures on a stand-alone engine as well as two powertrains. Those components where subjected to various drive cycles and vehicle conditions to evaluate the validity of the results over a broad range of test conditions. Overall, more than 1000 tests were performed. The data are compiled and analyzed in this report.

  1. Advanced aircraft for atmospheric research

    NASA Technical Reports Server (NTRS)

    Russell, P.; Wegener, S.; Langford, J.; Anderson, J.; Lux, D.; Hall, D. W.

    1991-01-01

    The development of aircraft for high-altitude research is described in terms of program objectives and environmental, technological limitations, and the work on the Perseus A aircraft. The need for these advanced aircraft is proposed in relation to atmospheric science issues such as greenhouse trapping, the dynamics of tropical cyclones, and stratospheric ozone. The implications of the study on aircraft design requirements is addressed with attention given to the basic categories of high-altitude, long-range, long-duration, and nap-of-the-earth aircraft. A strategy is delineated for a platform that permits unique stratospheric measurements and is a step toward a more advanced aircraft. The goal of Perseus A is to carry scientific air sampling payloads weighing at least 50 kg to altitudes of more than 25 km. The airfoils are designed for low Reynolds numbers, the structural weight is very low, and the closed-cycle power plant runs on liquid oxygen.

  2. Method of electric powertrain matching for battery-powered electric cars

    NASA Astrophysics Data System (ADS)

    Ning, Guobao; Xiong, Lu; Zhang, Lijun; Yu, Zhuoping

    2013-05-01

    The current match method of electric powertrain still makes use of longitudinal dynamics, which can't realize maximum capacity for on-board energy storage unit and can't reach lowest equivalent fuel consumption as well. Another match method focuses on improving available space considering reasonable layout of vehicle to enlarge rated energy capacity for on-board energy storage unit, which can keep the longitudinal dynamics performance almost unchanged but can't reach lowest fuel consumption. Considering the characteristics of driving motor, method of electric powertrain matching utilizing conventional longitudinal dynamics for driving system and cut-and-try method for energy storage system is proposed for passenger cars converted from traditional ones. Through combining the utilization of vehicle space which contributes to the on-board energy amount, vehicle longitudinal performance requirements, vehicle equivalent fuel consumption level, passive safety requirements and maximum driving range requirement together, a comprehensive optimal match method of electric powertrain for battery-powered electric vehicle is raised. In simulation, the vehicle model and match method is built in Matlab/simulink, and the Environmental Protection Agency (EPA) Urban Dynamometer Driving Schedule (UDDS) is chosen as a test condition. The simulation results show that 2.62% of regenerative energy and 2% of energy storage efficiency are increased relative to the traditional method. The research conclusions provide theoretical and practical solutions for electric powertrain matching for modern battery-powered electric vehicles especially for those converted from traditional ones, and further enhance dynamics of electric vehicles.

  3. Advancing musculoskeletal research with nanoscience.

    PubMed

    Brown, Cameron P

    2013-10-01

    Nanoscience has arrived. Biological applications of nanoscience are particularly prominent and can be useful in a range of disciplines. Advances in nanoscience are underpinning breakthroughs in biomedical research and are beginning to be adopted by the rheumatology and musculoskeletal science communities. Within these fields, nanoscience can be applied to imaging, drug delivery, implant development, regenerative medicine, and the characterization of nanoscale features of cells, matrices and biomaterials. Nanoscience and nanotechnology also provide means by which the interaction of cells with their environment can be studied, thereby increasing the understanding of disease and regenerative processes. Although its potential is clear, nanoscience research tends to be highly technical, generally targeting an audience of physicists, chemists, materials scientists and engineers, and is difficult for a general audience to follow. This Review aims to step back from the most technical aspects of nanoscience and provide a widely accessible view of how it can be applied to advance the field of rheumatology, with an emphasis on technologies that can have an immediate impact on rheumatology and musculoskeletal research.

  4. Advancing Concentrating Solar Power Research (Fact Sheet)

    SciTech Connect

    Not Available

    2014-02-01

    Researchers at the National Renewable Energy Laboratory (NREL) provide scientific, engineering, and analytical expertise to help advance innovation in concentrating solar power (CSP). This fact sheet summarizes how NREL is advancing CSP research.

  5. Intermediate/Advanced Research Design and Statistics

    NASA Technical Reports Server (NTRS)

    Ploutz-Snyder, Robert

    2009-01-01

    The purpose of this module is To provide Institutional Researchers (IRs) with an understanding of the principles of advanced research design and the intermediate/advanced statistical procedures consistent with such designs

  6. Recent advances in shoulder research.

    PubMed

    Killian, Megan L; Cavinatto, Leonardo; Galatz, Leesa M; Thomopoulos, Stavros

    2012-06-15

    Shoulder pathology is a growing concern for the aging population, athletes, and laborers. Shoulder osteoarthritis and rotator cuff disease represent the two most common disorders of the shoulder leading to pain, disability, and degeneration. While research in cartilage regeneration has not yet been translated clinically, the field of shoulder arthroplasty has advanced to the point that joint replacement is an excellent and viable option for a number of pathologic conditions in the shoulder. Rotator cuff disease has been a significant focus of research activity in recent years, as clinicians face the challenge of poor tendon healing and irreversible changes associated with rotator cuff arthropathy. Future treatment modalities involving biologics and tissue engineering hold further promise to improve outcomes for patients suffering from shoulder pathologies.

  7. FY 2007 Progress Report for Advanced Combustion Engine Technologies

    SciTech Connect

    None, None

    2007-12-01

    Advanced combustion engines have great potential for achieving dramatic energy efficiency improvements in light-duty vehicle applications, where it is suited to both conventional and hybrid- electric powertrain configurations. Light-duty vehicles with advanced combustion engines can compete directly with gasoline engine hybrid vehicles in terms of fuel economy and consumer-friendly driving characteristics; also, they are projected to have energy efficiencies that are competitive with hydrogen fuel cell vehicles when used in hybrid applications.Advanced engine technologies being researched and developed by the Advanced Combustion Engine R&D Sub-Program will also allow the use of hydrogen as a fuel in ICEs and will provide an energy-efficient interim hydrogen-based powertrain technology during the transition to hydrogen/fuelcell-powered transportation vehicles.

  8. Multi-objective component sizing of a power-split plug-in hybrid electric vehicle powertrain using Pareto-based natural optimization machines

    NASA Astrophysics Data System (ADS)

    Mozaffari, Ahmad; Vajedi, Mahyar; Chehresaz, Maryyeh; Azad, Nasser L.

    2016-03-01

    The urgent need to meet increasingly tight environmental regulations and new fuel economy requirements has motivated system science researchers and automotive engineers to take advantage of emerging computational techniques to further advance hybrid electric vehicle and plug-in hybrid electric vehicle (PHEV) designs. In particular, research has focused on vehicle powertrain system design optimization, to reduce the fuel consumption and total energy cost while improving the vehicle's driving performance. In this work, two different natural optimization machines, namely the synchronous self-learning Pareto strategy and the elitism non-dominated sorting genetic algorithm, are implemented for component sizing of a specific power-split PHEV platform with a Toyota plug-in Prius as the baseline vehicle. To do this, a high-fidelity model of the Toyota plug-in Prius is employed for the numerical experiments using the Autonomie simulation software. Based on the simulation results, it is demonstrated that Pareto-based algorithms can successfully optimize the design parameters of the vehicle powertrain.

  9. 32 CFR 37.1210 - Advanced research.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Advanced research. 37.1210 Section 37.1210... research. Research that creates new technology or demonstrates the viability of applying existing technology to new products and processes in a general way. Advanced research is most closely analogous...

  10. Conceptual design study of an Improved Gas Turbine (IGT) powertrain

    NASA Technical Reports Server (NTRS)

    Johnson, R. A.

    1979-01-01

    Design concepts for an improved automotive gas turbine powertrain are discussed. Twenty percent fuel economy improvement (over 1976), competitive costs (initial and life cycle), high reliability/life, low emissions, and noise/safety compliance were among the factors considered. The powertrain selected consists of a two shaft gas turbine engine with variable geometry aerodynamic components and a single disk rotating regenerator. The regenerator disk, gasifier turbine rotor, and several hot section flowpath parts are ceramic. The powertrain utilizes a conventional automatic transmission. The closest competitor was a single shaft turbine engine matched to a continuously variable transmission (CVT). Both candidate powertrain systems were found to be similar in many respects; however, the CVT represented a significant increase in development cost, technical risk, and production start-up costs over the conventional automatic transmission. Installation of the gas turbine powertrain was investigated for a transverse mounted, front wheel drive vehicle.

  11. Recent advances in betalain research.

    PubMed

    Strack, Dieter; Vogt, Thomas; Schliemann, Willibald

    2003-02-01

    Betalains replace the anthocyanins in flowers and fruits of plants of most families of the Caryophyllales. Unexpectedly, they were also found in some higher fungi. Whereas the anthocyanin-analogous functions of betalains in flower and fruit colouration are obvious, their role in fungi remains obscure. The nature of newly identified betalains as well as final structure elucidation of earlier putatively described compounds published within the last decade is compiled in this report. Recent advances in research on betalain biosynthesis is also covered, including description of some 'early' reactions, i.e. betalain-specific dopa formation in plants and fungi and extradiolic dopa cleavage in fungi. Work on betalain-specific glucosyltransferases (GTs) has given new insights into the evolution of secondary plant enzymes. It is proposed that these GTs are phylogenetically related to flavonoid GTs. It was found that the decisive steps in betalain biosynthesis, i.e. condensation of the betalain chromophore betalamic acid with cyclo-dopa and amino acids or amines in the respective aldimine formation of the red-violet betacyanins and the yellow betaxanthins, are most likely to be non-enzymatic. Betalains have attracted workers in applied fields because of their use for food colouring and their antioxidant and radical scavenging properties for protection against certain oxidative stress-related disorders.

  12. 32 CFR 37.1210 - Advanced research.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... research. Research that creates new technology or demonstrates the viability of applying existing technology to new products and processes in a general way. Advanced research is most closely analogous to precompetitive technology development in the commercial sector (i.e., early phases of research and development...

  13. 32 CFR 37.1210 - Advanced research.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... research. Research that creates new technology or demonstrates the viability of applying existing technology to new products and processes in a general way. Advanced research is most closely analogous to precompetitive technology development in the commercial sector (i.e., early phases of research and development...

  14. 32 CFR 37.1210 - Advanced research.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... research. Research that creates new technology or demonstrates the viability of applying existing technology to new products and processes in a general way. Advanced research is most closely analogous to precompetitive technology development in the commercial sector (i.e., early phases of research and development...

  15. 32 CFR 37.1210 - Advanced research.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... research. Research that creates new technology or demonstrates the viability of applying existing technology to new products and processes in a general way. Advanced research is most closely analogous to precompetitive technology development in the commercial sector (i.e., early phases of research and development...

  16. Adaptive powertrain control for plugin hybrid electric vehicles

    DOEpatents

    Kedar-Dongarkar, Gurunath; Weslati, Feisel

    2013-10-15

    A powertrain control system for a plugin hybrid electric vehicle. The system comprises an adaptive charge sustaining controller; at least one internal data source connected to the adaptive charge sustaining controller; and a memory connected to the adaptive charge sustaining controller for storing data generated by the at least one internal data source. The adaptive charge sustaining controller is operable to select an operating mode of the vehicle's powertrain along a given route based on programming generated from data stored in the memory associated with that route. Further described is a method of adaptively controlling operation of a plugin hybrid electric vehicle powertrain comprising identifying a route being traveled, activating stored adaptive charge sustaining mode programming for the identified route and controlling operation of the powertrain along the identified route by selecting from a plurality of operational modes based on the stored adaptive charge sustaining mode programming.

  17. New Advances in Brain Research.

    ERIC Educational Resources Information Center

    Seita, Lori Perkins

    2002-01-01

    Recent findings in brain research suggest the implementation of contemporary instructional practices is in order for base practices. Incorporating best practice research is critical for students to be competitive in a global market. This article provides a brief overview of educational philosophy, recent findings on brain research and language…

  18. Hybrid powertrain system including smooth shifting automated transmission

    DOEpatents

    Beaty, Kevin D.; Nellums, Richard A.

    2006-10-24

    A powertrain system is provided that includes a prime mover and a change-gear transmission having an input, at least two gear ratios, and an output. The powertrain system also includes a power shunt configured to route power applied to the transmission by one of the input and the output to the other one of the input and the output. A transmission system and a method for facilitating shifting of a transmission system are also provided.

  19. Control of gear shifts in dual clutch transmission powertrains

    NASA Astrophysics Data System (ADS)

    Walker, Paul D.; Zhang, Nong; Tamba, Richard

    2011-08-01

    To achieve the best possible responses during shifting in dual clutch transmissions it is commonplace to integrate clutch and engine control, while the clutch is used to match speeds between the engine and wheels via reduction gears, poor engine control can lead to extended engagement times and rough/harsh shift transients. This paper proposes a method for combined speed and torque control of vehicle powertrains with dual clutch transmissions for both the engine and clutches. The vehicle powertrain is modelled as a simple four degree of freedom system with reduction gears and two clutches. Including a detailed clutch hydraulic model, comprising of the direct acting solenoids and clutch piston with the hydraulic fluid modelled as a compressible fluid. Powertrain control is realised through control of clutch solenoids and manipulation of the engine throttle input. Sensitivity study of clutch performance evaluating inaccurate torque estimation demonstrated variance in the response of the hydraulic system, with an indicative simulation of poor estimation resulting in increased powertrain vibration during and after shifting. Simulations are conducted to demonstrate the capacity for this method of engine and clutch control to further reduce shift transients developed in dual clutch transmission powertrains. The obtained results also show that the adoption of torque based control techniques for both the clutch and engine, which makes use of the estimated target clutch torque, significantly improves the powertrain response as a result of reduction in the lockup discontinuities.

  20. Advances in Education Research. Volume 2, 1997.

    ERIC Educational Resources Information Center

    Advances in Education Research, 1997

    1997-01-01

    "Advances in Education Research" reprints previously published journal articles reporting on research supported in whole or in part by the Office of Educational Research and Improvement (OERI). The articles are selected from peer-reviewed/referred journals; the journals used are described briefy at the end of the volume. The articles in…

  1. Teaching Research Synthesis to Advanced Practice Nurses.

    ERIC Educational Resources Information Center

    Upchurch, Sandra; Brosnan, Christine A.; Grimes, Deanna E.

    2002-01-01

    A process for teaching research synthesis to advanced practice nurses includes two courses: a first research applications course in which students build bibliographic databases, practice statistical analysis, and develop search skills; and a second course in which they complete literature reviews or meta analyses of research on clinical practice…

  2. Control system for a hybrid powertrain system

    SciTech Connect

    Naqvi, Ali K.; Demirovic, Besim; Gupta, Pinaki; Kaminsky, Lawrence A.

    2014-09-09

    A vehicle includes a powertrain with an engine, first and second torque machines, and a hybrid transmission. A method for operating the vehicle includes operating the engine in an unfueled state, releasing an off-going clutch which when engaged effects operation of the hybrid transmission in a first continuously variable mode, and applying a friction braking torque to a wheel of the vehicle to compensate for an increase in an output torque of the hybrid transmission resulting from releasing the off-going clutch. Subsequent to releasing the off-going clutch, an oncoming clutch which when engaged effects operation of the hybrid transmission in a second continuously variable mode is synchronized. Subsequent to synchronization of the oncoming clutch, the oncoming clutch is engaged.

  3. Bringing Advanced Computational Techniques to Energy Research

    SciTech Connect

    Mitchell, Julie C

    2012-11-17

    Please find attached our final technical report for the BACTER Institute award. BACTER was created as a graduate and postdoctoral training program for the advancement of computational biology applied to questions of relevance to bioenergy research.

  4. Therapists and researchers: Advancing collaboration

    PubMed Central

    GARLAND, ANN F.; BROOKMAN-FRAZEE, LAUREN

    2016-01-01

    Collaborative partnerships between community-based clinicians and academic researchers have the potential to improve the relevance, utility, and feasibility of research, as well as the effectiveness of practice. Collaborative partnership research from a variety of fields can inform the development and maintenance of effective partnerships. In this paper we present a conceptual model of research-community practice partnership derived from literature across disciplines and then illustrate application of this model to one case example. The case example is a multi-year partnership between an interdisciplinary group of community-based psychotherapists and a team of mental health researchers. This partnership was initiated to support federally funded research on community-based out-patient mental health care for children with disruptive behavior problems, but it has evolved to drive and support new intervention studies with different clinical foci. Lessons learned from this partnership process will be shared and interpreted in the context of the presented research-practice partnership model. PMID:24224554

  5. Advancing Educational Policy by Advancing Research on Instruction

    ERIC Educational Resources Information Center

    Raudenbush, Stephen W.

    2008-01-01

    Understanding the impact of "instructional regimes" on student learning is central to advancing educational policy. Research on instructional regimes has parallels with clinical trials in medicine yet poses unique challenges because of the social nature of instruction: A child's potential outcome under a given regime depends on peers and teachers,…

  6. Method and apparatus for controlling hybrid powertrain system in response to engine temperature

    SciTech Connect

    Martini, Ryan D; Spohn, Brian L; Lehmen, Allen J; Cerbolles, Teresa L

    2014-10-07

    A method for controlling a hybrid powertrain system including an internal combustion engine includes controlling operation of the hybrid powertrain system in response to a preferred minimum coolant temperature trajectory for the internal combustion engine.

  7. Conceptual design study of an improved gas turbine powertrain

    NASA Technical Reports Server (NTRS)

    Chapman, W. I.

    1980-01-01

    The conceptual design for an improved gas turbine (IGT) powertrain and vehicle was investigated. Cycle parameters, rotor systems, and component technology were reviewed and a dual rotor gas turbine concept was selected and optimized for best vehicle fuel economy. The engine had a two stage centrifugal compressor with a design pressure ratio of 5.28, two axial turbine stages with advanced high temperature alloy integral wheels, variable power turbine nozzle for turbine temperature and output torque control, catalytic combustor, and annular ceramic recuperator. The engine was rated at 54.81 kW, using water injection on hot days to maintain vehicle acceleration. The estimated vehicle fuel economy was 11.9 km/l in the combined driving cycle, 43 percent over the 1976 compact automobile. The estimated IGT production vehicle selling price was 10 percent over the comparable piston engine vehicle, but the improved fuel economy and reduced maintenance and repair resulted in a 9 percent reduction in life cycle cost.

  8. Editorial - Advances in lightning research

    NASA Astrophysics Data System (ADS)

    2015-12-01

    This is the part I of a special issue dedicated to lightning research, consisting of papers presented at the 32nd International Conference on Lightning Protection (ICLP), held in Shanghai, China, in 2014, and several contributions invited by the guest editors to complement the subject matter of the papers selected from the ICLP. The papers from the ICLP were selected by the session chairmen of the ICLP and passed through the rigorous review process of the Journal of Solar Terrestrial and Atmospheric Physics (JASTP). The papers presented in this special issue contain subject matter pertinent to all aspects of lightning research both theoretical and experimental.

  9. Advances in Bilingual Education Research.

    ERIC Educational Resources Information Center

    Garcia, Eugene E., Ed.; Padilla, Raymond V., Ed.

    Papers on theory, technology, and public policy in bilingualism and bilingual education are collected in this volume designed to fill the need for systematic, high quality research related to bilingual populations in the United States. Part 1, "Language and Culture," contains five papers that discuss first and second language development,…

  10. ADVANCED GAS TURBINE SYSTEMS RESEARCH

    SciTech Connect

    Unknown

    1999-10-01

    The activities of the AGTSR Program during this reporting period are described in this quarterly report. The report text is divided into discussions on Membership, Administration, Technology Transfer (Workshop/Education) and Research. Items worthy of note are highlighted below with additional detail following in the text of the report.

  11. Research Advances: Onions Battle Osteoporosis

    ERIC Educational Resources Information Center

    King, Angela G.

    2005-01-01

    Researchers at the University of Bern in Switzerland have identified a compound in the popular vegetable that appears to decrease bone loss in laboratory studies using rat bone cells. It is suggested that eating onions might help prevent bone loss and osteoporosis, a disease, which predominantly affects older women.

  12. Advancements in Cotton Harvesting Research

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Cotton harvesting research within USDA ARS is focused on improving harvest productivity, cotton quality, and producer profitability. In recent years, our work has encompassed efforts to improve both spindle picker and brush-roll stripper harvesting systems. Specifically, work with cotton pickers i...

  13. Advances in developmental prosopagnosia research.

    PubMed

    Susilo, Tirta; Duchaine, Bradley

    2013-06-01

    Developmental prosopagnosia (DP) refers to face recognition deficits in the absence of brain damage. DP affects ∼2% of the population, and it often runs in families. DP studies have made considerable progress in identifying the cognitive and neural characteristics of the disorder. A key challenge is to develop a valid taxonomy of DP that will facilitate many aspects of research.

  14. Advances in Translational Medical Research

    DTIC Science & Technology

    2011-01-25

    the first nodes that receive lymph drainage allowed for a change in practice  Results of the clinical trial contributed to what is now the current...Raskind Seattle Institute for Biomedical and Clinical Research Got Nightmares? 2011 MHS Conference Quality of Life: Sentinel Lymph Node Biopsy 25...multi-center clinical trial testing the validity and accuracy of sentinel lymph node biopsy in predicting the spread of disease  Accurately identifying

  15. Advancing Manufacturing Research Through Competitions

    SciTech Connect

    Balakirsky, Stephen; Madhavan, Raj

    2009-01-01

    Competitions provide a technique for building interest and collaboration in targeted research areas. This paper will present a new competition that aims to increase collaboration amongst Universities, automation end-users, and automation manufacturers through a virtual competition. The virtual nature of the competition allows for reduced infrastructure requirements while maintaining realism in both the robotic equipment deployed and the scenarios. Details of the virtual environment as well as the competitions objectives, rules, and scoring metrics will be presented.

  16. 77 FR 3090 - Airworthiness Directives; BRP-POWERTRAIN GMBH & CO KG Rotax Reciprocating Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-23

    ...-07] RIN 2120-AA64 Airworthiness Directives; BRP--POWERTRAIN GMBH & CO KG Rotax Reciprocating Engines... airworthiness directive (AD) for BRP-- POWERTRAIN GMBH & CO KG Rotax 914 F2, 914 F3, and 914 F4 reciprocating.... The FAA amends Sec. 39.13 by adding the following new AD: 2012-01-07 BRP--POWERTRAIN GMBH & CO...

  17. 40 CFR 1036.615 - Engines with Rankine cycle waste heat recovery and hybrid powertrains.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... credits for hybrid powertrains that include energy storage systems and regenerative braking (including regenerative engine braking) and for engines that include Rankine-cycle (or other bottoming cycle) exhaust... powertrains are those powertrains that include features that recover and store energy from braking but...

  18. Advances in personality theory and research.

    PubMed Central

    Stelmack, R M

    1991-01-01

    This paper briefly describes important advances in personality research that have been achieved during the past 20 years in the development of a fundamental personality typology and in the determination of the heritability of personality traits. Research conducted at the University of Ottawa that has contributed to the exploration of the biological bases of the extraversion trait is summarized. PMID:1958646

  19. Research priorities for advanced fibrous composites

    NASA Technical Reports Server (NTRS)

    Baumann, K. J.; Swedlow, J. L.

    1981-01-01

    Priorities for research in advanced laminated fibrous composite materials are presented. Supporting evidence is presented in two bodies, including a general literature survey and a survey of aerospace composite hardware and service experience. Both surveys were undertaken during 1977-1979. Specific results and conclusions indicate that a significant portion of contemporary published research diverges from recommended priorites.

  20. [Research advances in porcine bocavirus].

    PubMed

    Zhai, Shao-Lun; Chen, Sheng-Nan; Wei, Wen-Kang

    2012-03-01

    Porcine bocavirus (PBoV) was considered as a new member of the genus Bocavirus of the subfamily Parvovirinae of the family Parvoviridae, which was discovered in Swedish swine herds with postweaning multisystemic wasting syndrome (PMWS) in 2009. At present, as an emerging pathogen, it was paid great attention by researchers at home and abroad. This paper referred to some published literatures and reviewed several aspects of PBoV including its finding, classification, genome structure and replication, epidemiology, associativity with diseases, cultural and diagnostic methods.

  1. [Research advancement about lactose intolerance].

    PubMed

    Yu, Qing; Yin, Shi-An

    2006-05-01

    Lactose intolerance associated with nutrition and health of human especially infant period of time and effect milk product intake. It is important significance to maintain health and cut down the aged risk of osteoporosis because lactose intolerance was understand about grouping, clinical symptom and diagnose. There are extensive perspective for understand prevent and control lactose intolerance for lactose gene polymorphism. It is effective method for earlier period detection gene screen with lactose typing for osteoporosis, however there are carry out multiplicity research in many ways to improve and control lactose intolerance

  2. ADVANCED GAS TURBINE SYSTEMS RESEARCH PROGRAM

    SciTech Connect

    Lawrence P. Golan

    2001-01-01

    The activities of the Advanced Gas Turbine Systems Research (AGTSR) program for this reporting period are described in this quarterly report. As this program administers research, we have included all program activity herein within the past quarter dated. More specific research progress reports are provided weekly at the request of the AGTSR COR and are being sent to NETL. As for the administration of this program, items worthy of note are presented in extended bullet format following the appropriate heading.

  3. ADVANCED GAS TURBINE SYSTEMS RESEARCH PROGRAM

    SciTech Connect

    Lawrence P. Golan

    2000-05-01

    The activities of the Advanced Gas Turbine Systems Research (AGTSR) program are described in the quarterly report. As this program administers research, we have included all program activity herein within the past quarter dated. More specific research progress reports are provided weekly at the request of the AGTSR COR and are being sent to NETL. As for the administration of this program, items worthy of note are presented in extended bullet format following the appropriate heading.

  4. Beyond competence: advance directives in dementia research.

    PubMed

    Jongsma, Karin Rolanda; van de Vathorst, Suzanne

    2015-01-01

    Dementia is highly prevalent and incurable. The participation of dementia patients in clinical research is indispensable if we want to find an effective treatment for dementia. However, one of the primary challenges in dementia research is the patients' gradual loss of the capacity to consent. Patients with dementia are characterized by the fact that, at an earlier stage of their life, they were able to give their consent to participation in research. Therefore, the phase when patients are still competent to decide offers a valuable opportunity to authorize research, by using an advance research directive (ARD). Yet, the use of ARDs as an authorization for research participation remains controversial. In this paper we discuss the role of autonomous decision-making and the protection of incompetent research subjects. We will show why ARDs are a morally defensible basis for the inclusion of this population in biomedical research and that the use of ARDs is compatible with the protection of incompetent research subjects.

  5. Comparative study of two different powertrains for a fuel cell hybrid bus

    NASA Astrophysics Data System (ADS)

    Gao, Dawei; Jin, Zhenhua; Zhang, Junzhi; Li, Jianqiu; Ouyang, Minggao

    2016-07-01

    The powertrain plays an essential role in improving the tractive performance and the fuel consumption of fuel cell hybrid vehicles. This paper presents a comparative study of two different powertrains for fuel cell hybrid buses. The significant difference between the two powertrains lies in the types and arrangements of the electrical motor. One powertrain employs an induction motor to drive the vehicle, while the other powertrain adopts two permanent magnetic synchronous motors for near-wheel propulsion. Besides, the tiny difference between the proposed powertrain is the supply path of the fuel cell accessories, which can have an effect on the powertrain efficiency. The component parameters and energy management strategies for the two powertrain are determined. The fuel cell hybrid buses equipped with the two powertrains are developed, and some road tests are achieved, according to the chosen procedures or driving cycles. The paper focuses on the tractive performance and energy analysis of the powertrains based on the testing results. Finally, the paper summarizes the relative merits of the proposed powertrains.

  6. Proposed research on advanced accelerator concepts

    SciTech Connect

    Davidson, R.C.; Wurtele, J.S.

    1991-09-01

    This report summarizes technical progress and accomplishments during the proposed three-year research on advanced accelerator concepts supported by the Department of Energy under Contract No. DE-FG02-88ER40465. A vigorous theoretical program has been pursued in critical problem areas related to advanced accelerator concepts and the basic equilibrium, stability, and radiation properties of intense charged particle beams. Broadly speaking, our research has made significant contributions in the following three major areas: Investigations of physics issues related to particle acceleration including two-beam accelerators and cyclotron resonance laser (CRL) accelerators; Investigations of RF sources including the free- electron lasers, cyclotron resonance masers, and relativistic magnetrons; Studies of coherent structures in electron plasmas and beams ranging from a low-density, nonrelativistic, pure electron plasma column to high-density, relativistic, non-neutral electron flow in a high-voltage diode. The remainder of this report presents theoretical and computational advances in these areas.

  7. ADVANCED GAS TURBINE SYSTEMS RESEARCH PROGRAM

    SciTech Connect

    Lawrence P. Golan

    2003-05-01

    The activities of the Advanced Gas Turbine Systems Research (AGTSR) program for the reporting period October 1, 2002 to December 31, 2002 are described in this quarterly report. No new membership, workshops, research projects, internships, faculty fellowships or special studies were initiated during this reporting period. Contract completion is set for June 30, 2003. During the report period, six research progress reports were received (3 final reports and 3 semi-annual reports). The University of Central Florida contract SR080 was terminated during this period, as UCF was unable to secure research facilities. AGTSR now projects that it will under spend DOE obligated funds by approximately 340-350K$.

  8. Defense Advanced Research Projects Agency Strategic Plan

    DTIC Science & Technology

    2007-02-01

    22 Figure 22: Warfighters in a DARPA Training Superiority program classroom ...technical Breakthroughs in DARPA or other research programs; program managers, it is easy to make decisions. This managemet style is essential to...Superiority program classroom . emotional involvement of multi-user computer games. 3.4. Advanced Manned and Unmanned Systems DARPA is working with the Army

  9. Powertrain with powersplit pump input and method of use thereof

    SciTech Connect

    Johnson, Kris W.; Rose, Charles E.

    2009-04-28

    A powertrain includes an engine operatively connected to a primary power consuming device to transmit power thereto. The powertrain also includes a motor and a pump. The power output of the motor is independent of the power output of the engine. An epicyclic geartrain includes first, second and third members. The first member is operatively connected to the engine to receive power therefrom. The second member is operatively connected to the motor to receive power therefrom. The third member is operatively connected to the pump to transmit power thereto.

  10. Coordinating Space Nuclear Research Advancement and Education

    SciTech Connect

    John D. Bess; Jonathon A. Webb; Brian J. Gross; Aaron E. Craft

    2009-11-01

    The advancement of space exploration using nuclear science and technology has been a goal sought by many individuals over the years. The quest to enable space nuclear applications has experienced many challenges such as funding restrictions; lack of political, corporate, or public support; and limitations in educational opportunities. The Center for Space Nuclear Research (CSNR) was established at the Idaho National Laboratory (INL) with the mission to address the numerous challenges and opportunities relevant to the promotion of space nuclear research and education.1 The CSNR is operated by the Universities Space Research Association and its activities are overseen by a Science Council comprised of various representatives from academic and professional entities with space nuclear experience. Program participants in the CSNR include academic researchers and students, government representatives, and representatives from industrial and corporate entities. Space nuclear educational opportunities have traditionally been limited to various sponsored research projects through government agencies or industrial partners, and dedicated research centers. Centralized research opportunities are vital to the growth and development of space nuclear advancement. Coordinated and focused research plays a key role in developing the future leaders in the space nuclear field. The CSNR strives to synchronize research efforts and provide means to train and educate students with skills to help them excel as leaders.

  11. Research Opportunities in Advanced Aerospace Concepts

    NASA Technical Reports Server (NTRS)

    Jones, Gregory S.; Bangert, Linda S.; Garber, Donald P.; Huebner, Lawrence D.; McKinley, Robert E.; Sutton, Kenneth; Swanson, Roy C., Jr.; Weinstein, Leonard

    2000-01-01

    This report is a review of a team effort that focuses on advanced aerospace concepts of the 21st Century. The paper emphasis advanced technologies, rather than cataloging every unusual aircraft that has ever been attempted. To dispel the myth that "aerodynamics is a mature science" an extensive list of "What we cannot do, or do not know" was enumerated. A zeit geist, a feeling for the spirit of the times, was developed, based on existing research goals. Technological drivers and the constraints that might influence these technological developments in a future society were also examined. The present status of aeronautics, space exploration, and non-aerospace applications, both military and commercial, including enabling technologies are discussed. A discussion of non-technological issues affecting advanced concepts research is presented. The benefit of using the study of advanced vehicles as a tool to uncover new directions for technology development is often necessary. An appendix is provided containing examples of advanced vehicle configurations currently of interest.

  12. Advances in fuel cell vehicle design

    NASA Astrophysics Data System (ADS)

    Bauman, Jennifer

    Factors such as global warming, dwindling fossil fuel reserves, and energy security concerns combine to indicate that a replacement for the internal combustion engine (ICE) vehicle is needed. Fuel cell vehicles have the potential to address the problems surrounding the ICE vehicle without imposing any significant restrictions on vehicle performance, driving range, or refuelling time. Though there are currently some obstacles to overcome before attaining the widespread commercialization of fuel cell vehicles, such as improvements in fuel cell and battery durability, development of a hydrogen infrastructure, and reduction of high costs, the fundamental concept of the fuel cell vehicle is strong: it is efficient, emits zero harmful emissions, and the hydrogen fuel can be produced from various renewable sources. Therefore, research on fuel cell vehicle design is imperative in order to improve vehicle performance and durability, increase efficiency, and reduce costs. This thesis makes a number of key contributions to the advancement of fuel cell vehicle design within two main research areas: powertrain design and DC/DC converters. With regards to powertrain design, this research first analyzes various powertrain topologies and energy storage system types. Then, a novel fuel cell-battery-ultracapacitor topology is presented which shows reduced mass and cost, and increased efficiency, over other promising topologies found in the literature. A detailed vehicle simulator is created in MATLAB/Simulink in order to simulate and compare the novel topology with other fuel cell vehicle powertrain options. A parametric study is performed to optimize each powertrain and general conclusions for optimal topologies, as well as component types and sizes, for fuel cell vehicles are presented. Next, an analytical method to optimize the novel battery-ultracapacitor energy storage system based on maximizing efficiency, and minimizing cost and mass, is developed. This method can be applied

  13. Advanced heat pump research and development

    NASA Astrophysics Data System (ADS)

    Kuliasha, M. A.

    The Office of Building Energy Research and Development of the U.S. Department of Energy (DOE), has been funding R&D in advanced heat pumps and appliances since 1976. Much of that research has been managed for DOE by the Oak Ridge National Laboratory (ORNL). The objective of the Building Equipment Research (BER) program at ORNL has been to generate new concepts and develop a technology base for improving the energy efficiency and load characteristics of energy conversion equipment used in residential and commercial buildings. The research being pursued to achieve these objectives falls under three general areas: thermally activated heat pumps (TAHP), refrigeration systems, and building equipment systems. The TAHP work is concentrated on three technologies: (1) absorption heat pumps; (2) Stirling engine-driven heat pumps; and (3) internal combustion (IC) engine-driven heat pumps. Major project areas in refrigeration systems research include electric heat pumps, ground-coupled heat pumps, and refigerant mixtures. In the building equipment systems areas, project areas include advanced distribution systems, advanced insulation for appliances, and commercial building equipment.

  14. Development of Research Projects in Advanced Laboratory

    NASA Astrophysics Data System (ADS)

    Yu, Ping; Guha, Suchi

    2008-04-01

    Advanced laboratory serves as a bridge spanning primary physics laboratory and scientific research or industrial activities for undergraduate students. Students not only study modern physics experiments and techniques but also acquire the knowledge of advanced instrumentation. It is of interest to encourage students using the knowledge into research projects at a later stage of the course. We have designed several scientific projects for advanced laboratory to promote student's abilities of independent research. Students work as a team to select the project and search literatures, to perform experiments, and to give presentations. During the research project, instructor only provides necessary equipment for the project without any pre-knowledge of results, giving students a real flavor of scientific research. Our initial attempt has shown some interesting results. We found that students showed a very strong motivation in these projects, and student performances exceeded our expectation. Almost all the students in our first batch of the course have now joined graduate school in Physics and Materials Science. In the future we will also arrange graduate students working with undergraduate students to build a collaborative environment. In addition, a more comprehensive method will be used to evaluate student achievements.

  15. Advanced energy projects FY 1997 research summaries

    SciTech Connect

    1997-09-01

    The mission of the Advanced Energy Projects (AEP) program is to explore the scientific feasibility of novel energy-related concepts that are high risk, in terms of scientific feasibility, yet have a realistic potential for a high technological payoff. The concepts supported by the AEP are typically at an early stage of scientific development. They often arise from advances in basic research and are premature for consideration by applied research or technology development programs. Some are based on discoveries of new scientific phenomena or involve exploratory ideas that span multiple scientific and technical disciplines which do not fit into an existing DOE program area. In all cases, the objective is to support evaluation of the scientific or technical feasibility of the novel concepts involved. Following AEP support, it is expected that each concept will be sufficiently developed to attract further funding from other sources to realize its full potential. Projects that involve evolutionary research or technology development and demonstration are not supported by AEP. Furthermore, research projects more appropriate for another existing DOE research program are not encouraged. There were 65 projects in the AEP research portfolio during Fiscal Year 1997. Eigheen projects were initiated during that fiscal year. This document consists of short summaries of projects active in FY 1997. Further information of a specific project may be obtained by contacting the principal investigator.

  16. [Advances in the biosynthesis research of ginsenosides].

    PubMed

    Yang, Jin-Ling; Gao, Li-Li; Zhu, Ping

    2013-02-01

    Ginsenosides are the main active components of medicinal herbs including Panax ginseng and Panax quinquefolium, which have potent effects of anti-tumor, anti-inflammatory, antioxidant and apoptosis inhibition. But the low content of ginsenosides limits its development and usage. At present, how to improve the production of ginsenosides by biological technology has been a new research focus. Some advances in the biosynthesis of ginsenosides by tissue culture and biotransformation have been made in recent years. So far at least twenty genes related to the biosynthesis of ginsenosides from Panax genus plants have been cloned and functionally identified, which has laid a good foundation for the study on the synthetic biology of ginsenosides. This review outlines recent advances in several aspects and is expected to provide a theoretical support to the thorough research of the pathway and regulation of ginsenosides biosynthesis.

  17. ISAAC - A Testbed for Advanced Composites Research

    NASA Technical Reports Server (NTRS)

    Wu, K. Chauncey; Stewart, Brian K.; Martin, Robert A.

    2014-01-01

    The NASA Langley Research Center is acquiring a state-of-art composites fabrication environment to support the Center's research and technology development mission. This overall system described in this paper is named ISAAC, or Integrated Structural Assembly of Advanced Composites. ISAAC's initial operational capability is a commercial robotic automated fiber placement system from Electroimpact, Inc. that consists of a multi-degree of freedom commercial robot platform, a tool changer mechanism, and a specialized automated fiber placement end effector. Examples are presented of how development of advanced composite materials, structures, fabrication processes and technology are enabled by utilizing the fiber placement end effector directly or with appropriate modifications. Alternatively, end effectors with different capabilities may either be bought or developed with NASA's partners in industry and academia.

  18. Systems Engineering Building Advances Power Grid Research

    SciTech Connect

    Virden, Jud; Huang, Henry; Skare, Paul; Dagle, Jeff; Imhoff, Carl; Stoustrup, Jakob; Melton, Ron; Stiles, Dennis; Pratt, Rob

    2015-08-19

    Researchers and industry are now better equipped to tackle the nation’s most pressing energy challenges through PNNL’s new Systems Engineering Building – including challenges in grid modernization, buildings efficiency and renewable energy integration. This lab links real-time grid data, software platforms, specialized laboratories and advanced computing resources for the design and demonstration of new tools to modernize the grid and increase buildings energy efficiency.

  19. Systems Engineering Building Advances Power Grid Research

    ScienceCinema

    Virden, Jud; Huang, Henry; Skare, Paul; Dagle, Jeff; Imhoff, Carl; Stoustrup, Jakob; Melton, Ron; Stiles, Dennis; Pratt, Rob

    2016-07-12

    Researchers and industry are now better equipped to tackle the nation’s most pressing energy challenges through PNNL’s new Systems Engineering Building – including challenges in grid modernization, buildings efficiency and renewable energy integration. This lab links real-time grid data, software platforms, specialized laboratories and advanced computing resources for the design and demonstration of new tools to modernize the grid and increase buildings energy efficiency.

  20. Medical technology advances from space research

    NASA Technical Reports Server (NTRS)

    Pool, S. L.

    1972-01-01

    Details of medical research and development programs, particularly an integrated medical laboratory, as derived from space technology are given. The program covers digital biotelemetry systems, automatic visual field mapping equipment, sponge electrode caps for clinical electroencephalograms, and advanced respiratory analysis equipment. The possibility of using the medical laboratory in ground based remote areas and regional health care facilities, as well as long duration space missions is discussed.

  1. Research Institute for Advanced Computer Science

    NASA Technical Reports Server (NTRS)

    Gross, Anthony R. (Technical Monitor); Leiner, Barry M.

    2000-01-01

    The Research Institute for Advanced Computer Science (RIACS) carries out basic research and technology development in computer science, in support of the National Aeronautics and Space Administration's missions. RIACS is located at the NASA Ames Research Center. It currently operates under a multiple year grant/cooperative agreement that began on October 1, 1997 and is up for renewal in the year 2002. Ames has been designated NASA's Center of Excellence in Information Technology. In this capacity, Ames is charged with the responsibility to build an Information Technology Research Program that is preeminent within NASA. RIACS serves as a bridge between NASA Ames and the academic community, and RIACS scientists and visitors work in close collaboration with NASA scientists. RIACS has the additional goal of broadening the base of researchers in these areas of importance to the nation's space and aeronautics enterprises. RIACS research focuses on the three cornerstones of information technology research necessary to meet the future challenges of NASA missions: (1) Automated Reasoning for Autonomous Systems. Techniques are being developed enabling spacecraft that will be self-guiding and self-correcting to the extent that they will require little or no human intervention. Such craft will be equipped to independently solve problems as they arise, and fulfill their missions with minimum direction from Earth; (2) Human-Centered Computing. Many NASA missions require synergy between humans and computers, with sophisticated computational aids amplifying human cognitive and perceptual abilities; (3) High Performance Computing and Networking. Advances in the performance of computing and networking continue to have major impact on a variety of NASA endeavors, ranging from modeling and simulation to data analysis of large datasets to collaborative engineering, planning and execution. In addition, RIACS collaborates with NASA scientists to apply information technology research to a

  2. UZIG USGS research: Advances through interdisciplinary interaction

    USGS Publications Warehouse

    Nimmo, J.R.; Andraski, B.J.; Rafael, M.-C.

    2009-01-01

    Because vadose zone research relates to diverse disciplines, applications, and modes of research, collaboration across traditional operational and topical divisions is especially likely to yield major advances in understanding. The Unsaturated Zone Interest Group (UZIG) is an informal organization sponsored by the USGS to encourage and support interdisciplinary collaboration in vadose or unsaturated zone hydrologic research across organizational boundaries. It includes both USGS and non-USGS scientists. Formed in 1987, the UZIG operates to promote communication, especially through periodic meetings with presentations, discussions, and fi eld trips. The 10th meeting of the UZIG at Los Alamos, NM, in August 2007 was jointly sponsored by the USGS and Los Alamos National Laboratory. Presentations at this meeting served as the initial basis for selecting papers for this special section of Vadose Zone Journal, the purpose of which is to present noteworthy cuting-edge unsaturated zone research promoted by, facilitated by, or presented in connection with the UZIG. ?? Soil Science Society of America.

  3. ADVANCED GAS TURBINE SYSTEMS RESEARCH PROGRAM

    SciTech Connect

    Lawrence P. Golan

    2003-05-01

    The quarterly activities of the Advanced Gas Turbine Systems Research (AGTSR) program are described in this quarterly report. As this program administers research, we have included all program activity herein within the past quarter as dated. More specific research progress reports are provided weekly at the request of the AGTSR COR and are being sent to NETL As for the administration of this program, items worthy of note are presented in extended bullet format following the appropriate heading. No new memberships, workshops, research projects, internships, faculty fellowships or special studies were initiated during this reporting period. Contract completion is set for June 30, 2003. During the report period, nine subcontractor reports were received (5 final reports and 4 semi-annual reports). The report technology distribution is as follows: 3--aero-heat transfer, 2--combustion and 4--materials. AGTSR continues to project that it will under spend DOE obligated funds by approximately $329K.

  4. JPL basic research review. [research and advanced development

    NASA Technical Reports Server (NTRS)

    1977-01-01

    Current status, projected goals, and results of 49 research and advanced development programs at the Jet Propulsion Laboratory are reported in abstract form. Areas of investigation include: aerodynamics and fluid mechanics, applied mathematics and computer sciences, environment protection, materials science, propulsion, electric and solar power, guidance and navigation, communication and information sciences, general physics, and chemistry.

  5. Center for Advanced Gas Turbine Systems Research

    SciTech Connect

    Golan, L.P.

    1992-12-31

    An unregulated conventional power station based on the Rankine Cycle typically bums pulverized coal in a boiler that exports steam for expansion through a steam turbine which ultimately drives an electric generator. The flue gases are normally cleaned of particulates by an electrostatic precipitator or bag house. A basic cycle such as this will have an efficiency of approximately 35% with 10% of the energy released through the stack and 55% to cooling water. Advanced gas turbine based combustion systems have the potential to be environmentally and commercially superior to existing conventional technology. however, to date, industry, academic, and government groups have not coordinated their effort to commercialize these technologies. The Center for Advanced Gas Turbine Systems Research will provide the medium to support effective commercialization of this technology. Several cycles or concepts for advanced gas turbine systems that could be fired on natural gas or could be adapted into coal based systems have been proposed (for examples, see Figures 4, 5, 6, and 7) (2) all with vary degrees of complexity, research needs, and system potential. Natural gas fired power systems are now available with 52% efficiency ratings; however, with a focused base technology program, it is expected that the efficiency levels can be increased to the 60% level and beyond. This increase in efficiency will significantly reduce the environmental burden and reduce the cost of power generation.

  6. Center for Advanced Gas Turbine Systems Research

    SciTech Connect

    Golan, L.P.

    1992-01-01

    An unregulated conventional power station based on the Rankine Cycle typically bums pulverized coal in a boiler that exports steam for expansion through a steam turbine which ultimately drives an electric generator. The flue gases are normally cleaned of particulates by an electrostatic precipitator or bag house. A basic cycle such as this will have an efficiency of approximately 35% with 10% of the energy released through the stack and 55% to cooling water. Advanced gas turbine based combustion systems have the potential to be environmentally and commercially superior to existing conventional technology. however, to date, industry, academic, and government groups have not coordinated their effort to commercialize these technologies. The Center for Advanced Gas Turbine Systems Research will provide the medium to support effective commercialization of this technology. Several cycles or concepts for advanced gas turbine systems that could be fired on natural gas or could be adapted into coal based systems have been proposed (for examples, see Figures 4, 5, 6, and 7) (2) all with vary degrees of complexity, research needs, and system potential. Natural gas fired power systems are now available with 52% efficiency ratings; however, with a focused base technology program, it is expected that the efficiency levels can be increased to the 60% level and beyond. This increase in efficiency will significantly reduce the environmental burden and reduce the cost of power generation.

  7. Advanced energy projects FY 1994 research summaries

    SciTech Connect

    Not Available

    1994-09-01

    The Division of Advanced Energy Projects (AEP) provides support to explore the feasibility of novel, energy-related concepts that evolve from advances in basic research. These concepts are typically at an early stage of scientific definition and, therefore, are premature for consideration by applied research or technology development programs. The AEP also supports high-risk, exploratory concepts that do not readily fit into a program area but could have several applications that may span scientific disciplines or technical areas. Projects supported by the Division arise from unsolicited ideas and concepts submitted by researchers. The portfolio of projects is dynamic and reflects the broad role of the Department in supporting research and development for improving the Nation`s energy outlook. FY 1994 projects include the following topical areas: novel materials for energy technology; renewable and biodegradable materials; exploring uses of new scientific discoveries; alternate pathways to energy efficiency; alternative energy sources; and innovative approaches to waste treatment and reduction. Summaries are given for 66 projects.

  8. Advances in craniosynostosis research and management.

    PubMed

    Guimarães-Ferreira, J; Miguéns, J; Lauritzen, C

    2004-01-01

    The purpose of the present paper is to analyze the most recent advances in the field of craniosynostosis basic and clinical research and management, and to give an overview of the more frequently adopted surgical strategies. After reviewing some basic concepts regarding normal craniofacial embryology and growth, aetiopathogenesis of craniosynostosis and craniofacial dysostosis, classification and diagnosis and historical evolution of surgical treatment, the authors elaborate on a selection of topics that have modified our current understanding of and therapeutical approach to these disease processes. Areas covered include advances in molecular biology and genetics, imaging techniques and surgical planning, resorbable fixation technology, bone substitutes and tissue engineering, distraction osteogenesis and the spring-mediated cranioplasties, resorbable distractor devices, minimally invasive surgery and in utero surgery. A review of the main subtypes of craniosynostosis and craniofacial dysostosis is presented, including their specific clinical features and a commentary on the presently available surgical options.

  9. Research for Lunar Exploration: ADVANCE Program

    NASA Technical Reports Server (NTRS)

    Rojdev, Kristina

    2009-01-01

    This viewgraph presentation reviews the work that the author has been involved with in her undergraduate and graduate education and the ADVANCE Program. One project was the Lunar Entry and Approach Platform For Research On Ground (LEAPFROG). This vehicle was to be a completely autonomous vehicle, and was developed in successive academic years with increases in the perofmamnce and capability of the simulated lander. Another research project for the PhD was on long-term lunar radiation degradation of materials to be used for construction of lunar habitats. This research has concentrated on developing and testing light-weight composite materials with high strength characteristics, and the ability of these composite materials to withstand the lunar radiation environment.

  10. Advanced Satellite Research Project: SCAR Research Database. Bibliographic analysis

    NASA Technical Reports Server (NTRS)

    Pelton, Joseph N.

    1991-01-01

    The literature search was provided to locate and analyze the most recent literature that was relevant to the research. This was done by cross-relating books, articles, monographs, and journals that relate to the following topics: (1) Experimental Systems - Advanced Communications Technology Satellite (ACTS), and (2) Integrated System Digital Network (ISDN) and Advance Communication Techniques (ISDN and satellites, ISDN standards, broadband ISDN, flame relay and switching, computer networks and satellites, satellite orbits and technology, satellite transmission quality, and network configuration). Bibliographic essay on literature citations and articles reviewed during the literature search task is provided.

  11. Advancing research transdisciplinarity within our discipline.

    PubMed

    Sadovsky, Yoel; Esplin, M Sean; Garite, Thomas J; Nelson, D Michael; Parry, Samuel I; Saade, George R; Socol, Michael L; Spong, Catherine Y; Varner, Michael W; D'Alton, Mary E

    2014-09-01

    Advancing biomedical knowledge is crucial to the understanding of disease pathophysiology, diagnosis, treatment, and the maintenance of health. Whereas collaborative pursuits among basic and translational scientists, clinical researchers, and clinicians should advance biomedical progress and its translation to better medicine. The field of obstetrics and gynecology and its subspecialties has not escaped this problem. Obstetrics and gynecology specialists and subspecialists have limited opportunities to interact with translational or basic investigators, and cross-fertilization and collaborations are further challenged by the current healthcare and funding climate. This opinion manuscript focuses on the field of maternal-fetal medicine, serving as an example that illustrates the risks and opportunities that might exist within our obstetrics and gynecology academic community. A Pregnancy Task Force recently sought to identify ways to overcome hurdles related to research training, and ensure a sufficient pool of physician-scientists pursuing pertinent questions in the field. The group discussed strategies to promote a culture of intellectual curiosity and research excellence, securing additional resources for trainees, and attracting current and next generation basic, translational, and clinical scholars to our field. Recommendations encompassed activities within annual academic meetings, training initiatives, and additional funding opportunities. Inferences from these discussions can be made to all obstetrics and gynecology subspecialty areas.

  12. Advanced instrumentation for aircraft icing research

    NASA Technical Reports Server (NTRS)

    Bachalo, W.; Smith, J.; Rudoff, R.

    1990-01-01

    A compact and rugged probe based on the phase Doppler method was evaluated as a means for characterizing icing clouds using airborne platforms and for advancing aircraft icing research in large scale wind tunnels. The Phase Doppler Particle Analyzer (PDPA) upon which the new probe was based is now widely recognized as an accurate method for the complete characterization of sprays. The prototype fiber optic-based probe was evaluated in simulated aircraft icing clouds and found to have the qualities essential to providing information that will advance aircraft icing research. Measurement comparisons of the size and velocity distributions made with the standard PDPA and the fiber optic probe were in excellent agreement as were the measurements of number density and liquid water content. Preliminary testing in the NASA Lewis Icing Research Tunnel (IRT) produced reasonable results but revealed some problems with vibration and signal quality at high speeds. The cause of these problems were identified and design changes were proposed to eliminate the shortcomings of the probe.

  13. Advances in neural networks research: an introduction.

    PubMed

    Kozma, Robert; Bressler, Steven; Perlovsky, Leonid; Venayagamoorthy, Ganesh Kumar

    2009-01-01

    The present Special Issue "Advances in Neural Networks Research: IJCNN2009" provides a state-of-art overview of the field of neural networks. It includes 39 papers from selected areas of the 2009 International Joint Conference on Neural Networks (IJCNN2009). IJCNN2009 took place on June 14-19, 2009 in Atlanta, Georgia, USA, and it represents an exemplary collaboration between the International Neural Networks Society and the IEEE Computational Intelligence Society. Topics in this issue include neuroscience and cognitive science, computational intelligence and machine learning, hybrid techniques, nonlinear dynamics and chaos, various soft computing technologies, intelligent signal processing and pattern recognition, bioinformatics and biomedicine, and engineering applications.

  14. Alzheimer's disease: research advances and medical reality.

    PubMed

    Seiguer, Erica

    2005-07-01

    Alzheimer's disease was the eighth-leading cause of death in 2001. There is no cure and no effective treatment. Alzheimer's disease presents policy-makers with several challenges, including the level of funding and direction of federally funded research, as well as the cost pressures on Medicare and Medicaid of long-term care. These challenges will increase in intensity as demographic changes, particularly the aging of baby boomers, take hold. Better prevention of Alzheimer's, advances in therapy, and appropriate care modalities will likely require significant investment.

  15. Research on Advanced Thin Film Batteries

    SciTech Connect

    Goldner, Ronald B.

    2003-11-24

    During the past 7 years, the Tufts group has been carrying out research on advanced thin film batteries composed of a thin film LiCo02 cathode (positive electrode), a thin film LiPON (lithium phosphorous oxynitride) solid electrolyte, and a thin film graphitic carbon anode (negative electrode), under grant DE FG02-95ER14578. Prior to 1997, the research had been using an rfsputter deposition process for LiCoOi and LiPON and an electron beam evaporation or a controlled anode arc evaporation method for depositing the carbon layer. The pre-1997 work led to the deposition of a single layer cell that was successfully cycled for more than 400 times [1,2] and the research also led to the deposition of a monolithic double-cell 7 volt battery that was cycled for more than 15 times [3]. Since 1997, the research has been concerned primarily with developing a research-worthy and, possibly, a production-worthy, thin film deposition process, termed IBAD (ion beam assisted deposition) for depositing each ofthe electrodes and the electrolyte of a completely inorganic solid thin film battery. The main focus has been on depositing three materials - graphitic carbon as the negative electrode (anode), lithium cobalt oxide (nominally LiCoCb) as the positive electrode (cathode), and lithium phosphorus oxynitride (LiPON) as the electrolyte. Since 1998, carbon, LiCoOa, and LiPON films have been deposited using the IBAD process with the following results.

  16. Advanced cyberinfrastructure for research in Geodynamics

    NASA Astrophysics Data System (ADS)

    Manea, Marina; Constantin Manea, Vlad

    2010-05-01

    Today's scientists need access to new information technology capabilities, able to perform high-resolution complex computing simulations in a reasonable time frame. Sophisticated simulation tools allow us to study phenomena that can never be observed or replicated by standard laboratory experiments. Modeling complex natural processes in general, and numerical computation in particular, represents today an essential need of research, and all modern research centers benefit from a computing center of one form or another. The combined power of hardware and sophisticated software, visualization tools, and scientific applications produced and used by interdisciplinary research teams make possible nowadays to advance the frontiers of science and to pose new key scientific questions. Cyberinfrastructure integrates hardware for high speed computing, a collection of highly specialized software and tools, and a powerful visualization tool. A new interdisciplinary research domain is emerging at the interface of geosciences and computing with essential inputs from geology and geophysics. In this study we show how to rapidly deploy a low-cost high-performance computing cluster (HPCC) and a 3D visualization system that can be used both in teaching and research in geosciences. Also, we present several geodynamic simulations performed with such systems.

  17. Advanced Energy Projects FY 1996 research summaries

    SciTech Connect

    1996-09-01

    The mission of the Advanced Energy Projects Division (AEP) is to explore the scientific feasibility of novel energy-related concepts. These concepts are typically at an early stage of scientific development and, therefore, are premature for consideration by applied research or technology development programs. The portfolio of projects is dynamic, but reflects the broad role of the Department in supporting research and development for improving the Nation`s energy posture. Topical areas presently receiving support include: alternative energy sources; innovative concepts for energy conversion and storage; alternate pathways to energy efficiency; exploring uses of new scientific discoveries; biologically-based energy concepts; renewable and biodegradable materials; novel materials for energy technology; and innovative approaches to waste treatment and reduction. Summaries of the 70 projects currently being supported are presented. Appendices contain budget information and investigator and institutional indices.

  18. Research opportunities at the Advanced Light Source

    NASA Astrophysics Data System (ADS)

    Robinson, A. L.; Schlachter, A. S.

    1991-05-01

    The Advanced Light Source (ALS), now under construction at the Lawrence Berkeley Laboratory, is a third-generation synchrotron radiation facility based on a low-emittance, 1.5-GeV electron storage ring with ten long straight sections available for insertion devices and, initially, 24 bend-magnet ports. Undulators will provide high-brightness radiation at photon energies from below 10 eV to above 2 keV; wiggler and bend-magnet radiation will extend the spectral coverage with high fluxes to above 10 keV. Scheduled to begin operations as a US Department of Energy national user facility in the spring of 1993, the ALS will support an extensive research program in which soft X-ray and ultraviolet radiation is used to study matter in all its varied gaseous, liquid and solid forms. Participating research teams to implement the initial scientific program have been selected.

  19. Geysers advanced direct contact condenser research

    SciTech Connect

    Henderson, J.; Bahning, T.; Bharathan, D.

    1997-12-31

    The first geothermal application of the Advanced Direct Contact Condenser (ADCC) technology developed by the National Renewable Energy Laboratory (NREL) is now operational and is being tested at The Geysers Power Plant Unit 11. This major research effort is being supported through the combined efforts of NREL, The Department of Energy (DOE), and Pacific Gas and Electric (PG&E). NREL and PG&E have entered into a Cooperative Research And Development Agreement (CRADA) for a project to improve the direct-contact condenser performance at The Geysers Power Plant. This project is the first geothermal adaptation of an advanced condenser design developed for the Ocean Thermal Energy Conversion (OTEC) systems. PG&E expects this technology to improve power plant performance and to help extend the life of the steam field by using steam more efficiently. In accordance with the CRADA, no money is transferred between the contracting parties. In this case the Department of Energy is funding NREL for their efforts in this project and PG&E is contributing funds in kind. Successful application of this technology at The Geysers will provide a basis for NREL to continue to develop this technology for other geothermal and fossil power plant systems.

  20. 75 FR 76038 - General Motors Corporation, Powertrain Flint North, Including On-Site Leased Workers From Allegis...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ... Employment and Training Administration General Motors Corporation, Powertrain Flint North, Including On- Site Leased Workers From Allegis Group Services, Securitas and Knight Management, Flint, MI; Amended... General Motors Corporation, Powertrain Flint North, including on-site leased workers from Allegis...

  1. Characterization of the powertrain components for a hybrid quadricycle

    NASA Astrophysics Data System (ADS)

    De Santis, M.; Agnelli, S.; Silvestri, L.; Di Ilio, G.; Giannini, O.

    2016-06-01

    This paper presents the experimental characterization of a prototyping hybrid electric quadricycle, which is equipped with two independently actuated hub (in-wheel) motors and powered by a 51 V 132 Ah LiFeYPO4 battery pack. Such a vehicle employs two hub motors located in the rear axles in order to independently drive/brake the rear wheels; such architecture allows to implement a torque vectoring system to improve the vehicle dynamics. Due to its actuation flexibility, energy efficiency and performance potentials, this architecture is one of the promising powertrain design for electric quadricycle. Experimental data obtained from measurements on the vehicle powertrain components going from the battery pack to the inverter and to the in-wheel motor were employed to generate the hub motor torque response and power efficiency maps in both driving and regenerative braking modes. Furthermore, the vehicle is equipped with a gasoline internal combustion engine as range extender whose efficiency was also characterized.

  2. Advanced Materials for Exploration Task Research Results

    NASA Technical Reports Server (NTRS)

    Cook, M. B. (Compiler); Murphy, K. L.; Schneider, T.

    2008-01-01

    The Advanced Materials for Exploration (AME) Activity in Marshall Space Flight Center s (MSFC s) Exploration Science and Technology Directorate coordinated activities from 2001 to 2006 to support in-space propulsion technologies for future missions. Working together, materials scientists and mission planners identified materials shortfalls that are limiting the performance of long-term missions. The goal of the AME project was to deliver improved materials in targeted areas to meet technology development milestones of NASA s exploration-dedicated activities. Materials research tasks were targeted in five areas: (1) Thermal management materials, (2) propulsion materials, (3) materials characterization, (4) vehicle health monitoring materials, and (5) structural materials. Selected tasks were scheduled for completion such that these new materials could be incorporated into customer development plans.

  3. Advanced Gas Turbine (AGT): Power-train system development

    NASA Technical Reports Server (NTRS)

    Helms, H. E.; Johnson, R. A.; Gibson, R. K.; Smith, L. B.

    1983-01-01

    Technical work on the design and effort leading to the testing of a 74.5 kW (100 hp) automotive gas turbine is described. The general effort was concentrated on building an engine for test starting in July. The buildup progressed with only routine problems and the engine was delivered to the test stand 9 July. In addition to the engine build effort, work continued in selected component areas. Ceramic turbine parts were built and tested. Burst tests of ceramic rotors show strengths are approaching that achieved in test bars; proof testing is required for acceptable strength ceramic vanes. Over 25 hours was accumulated on the combustor rig in three test modes: pilot nozzle only, start nozzle, and main nozzle operation. Satisfactory ignition was achieved for a wide range of starting speeds and the lean blowout limit was as low as 0.06 kg/b (0.14 lb/hr). Lean blowout was more a function of nozzle atomization than fuel/air ratio. A variety of cycle points were tested. Transition from start nozzle flow to main nozzle flow was done manually without difficulty. Regenerator parts were qualification tested without incident and the parts were assembled on schedule. Rig based performance matched first build requirements. Repeated failures in the harmonic drive gearbox during rig testing resulted in that concept being abandoned for an alternate scheme.

  4. Advanced Gas Turbine (AGT) powertrain system development for automotive applications

    NASA Technical Reports Server (NTRS)

    1982-01-01

    Topics covered include the AGT 101 engine test; compressor design modification; cold air turbine testing; Mod 1 alloy turbine rotor fabrication; combustion aspects; regenerator development; and thermal screening tests for ceramic materials. The foil gas bearings, rotor dynamics, and AGT controls and accessories are also considered.

  5. Advanced Gas Turbine (AGT) powertrain system development for automotive applications

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Rotor dynamic instability investigations were conducted. Forward ball bearing hydraulic mount configurations were tested with little effect. Trial assembly of S/N 002 ceramic engine was initiated. Impeller design activities were completed on the straight line element (SLE) blade definition to address near-net-shape powder metal die forging. Performance characteristics of the Baseline Test 2A impeller were closely preserved. The modified blading design has been released for tooling procurement. Developmental testing of the diffusion flame combustor (DFC) for initial use in the S/N 002 2100 F ceramic structures engine was completed. A natural gas slave preheater was designed and fabricated. Preliminary regenerator static seal rig testing showed a significant reduction in leakage and sensitivity to stack height. Ceramic screening tests were completed and two complete sets of ceramic static structures were qualified for engine testing. Efforts on rotor dynamics development to resolve subsynchronous motion were continued.

  6. Advanced Gas Turbine (AGT) powertrain system development for automotive applications

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Compressor development, turbine, combustion, regenerator system, gearbox/transmission, ceramic material and component development, foil gas bearings, bearings and seals, rotor dynamics development, and controls and accessories are discussed.

  7. Advanced optical diagnostics in hypersonic research

    NASA Astrophysics Data System (ADS)

    Cattolica, Robert J.

    1988-10-01

    The renewed emphasis on hypersonic research has stimulated a resurgence of interest in experimental methods for the study of high-speed flows. Improvement in the physical and chemical models used in computational fluid dynamic simulation of hypersonic flows requires a modern experimental data base. Optical diagnostics provide the capability to make nonintrusive measurements of density, temperature, velocity, and species concentration in hypersonic flows. The short test time available in hypersonic wind tunnels or flight experiments necessitates spectroscopic methods capable of producing high signal levels. Fluorescence methods based on laser or electron-beam excitation satisfy this requirement. For flight experiments, electron-beam excitation offers a number of advantages over laser excitation that include small device size, high electrical efficiency, and multiple-state and species-selective excitation. Disadvantages of the electron beam fluorescence (EBF) technique included a complex excitation mechanism and some limitations in high-density applications. Laser fluorescence methods (LIF) have been developed extensively in recent years for combustion research, but need further advances in miniaturization of lasers for application to in-flight hypersonic combustion and aerodynamic experiments. Both techniques require a fundamental understanding of the complications introduced by physical effects such as energy transfer and quenching of the fluorescence signal. With modern electro-optic instrumentation it is now possible to examine in detail the influence of these phenomena on EBF and LIF fluorescence spectra in the laboratory and to extend these measurement techniques for use in flight research. To illustrate some of the research required to develop these methods to address issues relevent to hypersonic flight, examples of experiments on the use of EBF and LIF spectroscopy for the measurement of nitric oxide concentration are presented.

  8. 40 CFR 1036.615 - Engines with Rankine cycle waste heat recovery and hybrid powertrains.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... credits for hybrid powertrains that include energy storage systems and regenerative braking (including regenerative engine braking) and for engines that include Rankine-cycle (or other bottoming cycle) exhaust energy recovery systems. (a) Hybrid powertrains. The following provisions apply for pre-transmission...

  9. 40 CFR 1036.615 - Engines with Rankine cycle waste heat recovery and hybrid powertrains.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... credits for hybrid powertrains that include energy storage systems and regenerative braking (including regenerative engine braking) and for engines that include Rankine-cycle (or other bottoming cycle) exhaust energy recovery systems. (a) Pre-transmission hybrid powertrains. Test pre-transmission...

  10. Advances in nicotine research in Addiction Biology.

    PubMed

    Bernardi, Rick E

    2015-09-01

    The aim of Addiction Biology is to advance our understanding of the action of drugs of abuse and addictive processes via the publication of high-impact clinical and pre-clinical findings resulting from behavioral, molecular, genetic, biochemical, neurobiological and pharmacological research. As of 2013, Addiction Biology is ranked number 1 in the category of Substance Abuse journals (SCI). Occasionally, Addiction Biology likes to highlight via review important findings focused on a particular topic and recently published in the journal. The current review summarizes a number of key publications from Addiction Biology that have contributed to the current knowledge of nicotine research, comprising a wide spectrum of approaches, both clinical and pre-clinical, at the cellular, molecular, systems and behavioral levels. A number of findings from human studies have identified, using imaging techniques, alterations in common brain circuits, as well as morphological and network activity changes, associated with tobacco use. Furthermore, both clinical and pre-clinical studies have characterized a number of mechanistic targets critical to understanding the effects of nicotine and tobacco addiction. Together, these findings will undoubtedly drive future studies examining the dramatic impact of tobacco use and the development of treatments to counter nicotine dependence.

  11. Eagleworks Laboratories: Advanced Propulsion Physics Research

    NASA Technical Reports Server (NTRS)

    White, Harold; March, Paul; Williams, Nehemiah; ONeill, William

    2011-01-01

    NASA/JSC is implementing an advanced propulsion physics laboratory, informally known as "Eagleworks", to pursue propulsion technologies necessary to enable human exploration of the solar system over the next 50 years, and enabling interstellar spaceflight by the end of the century. This work directly supports the "Breakthrough Propulsion" objectives detailed in the NASA OCT TA02 In-space Propulsion Roadmap, and aligns with the #10 Top Technical Challenge identified in the report. Since the work being pursued by this laboratory is applied scientific research in the areas of the quantum vacuum, gravitation, nature of space-time, and other fundamental physical phenomenon, high fidelity testing facilities are needed. The lab will first implement a low-thrust torsion pendulum (<1 uN), and commission the facility with an existing Quantum Vacuum Plasma Thruster. To date, the QVPT line of research has produced data suggesting very high specific impulse coupled with high specific force. If the physics and engineering models can be explored and understood in the lab to allow scaling to power levels pertinent for human spaceflight, 400kW SEP human missions to Mars may become a possibility, and at power levels of 2MW, 1-year transit to Neptune may also be possible. Additionally, the lab is implementing a warp field interferometer that will be able to measure spacetime disturbances down to 150nm. Recent work published by White [1] [2] [3] suggests that it may be possible to engineer spacetime creating conditions similar to what drives the expansion of the cosmos. Although the expected magnitude of the effect would be tiny, it may be a "Chicago pile" moment for this area of physics.

  12. Indentation Methods in Advanced Materials Research Introduction

    SciTech Connect

    Pharr, George Mathews; Cheng, Yang-Tse; Hutchings, Ian; Sakai, Mototsugu; Moody, Neville; Sundararajan, G.; Swain, Michael V.

    2009-01-01

    Since its commercialization early in the 20th century, indentation testing has played a key role in the development of new materials and understanding their mechanical behavior. Progr3ess in the field has relied on a close marriage between research in the mechanical behavior of materials and contact mechanics. The seminal work of Hertz laid the foundations for bringing these two together, with his contributions still widely utilized today in examining elastic behavior and the physics of fracture. Later, the pioneering work of Tabor, as published in his classic text 'The Hardness of Metals', exapdned this understanding to address the complexities of plasticity. Enormous progress in the field has been achieved in the last decade, made possible both by advances in instrumentation, for example, load and depth-sensing indentation and scanning electron microscopy (SEM) and transmission electron microscopy (TEM) based in situ testing, as well as improved modeling capabilities that use computationally intensive techniques such as finite element analysis and molecular dynamics simulation. The purpose of this special focus issue is to present recent state of the art developments in the field.

  13. Land reclamation: Advances in research technology

    SciTech Connect

    Younos, T.; Diplas, P.; Mostaghimi, S.

    1992-01-01

    Land reclamation encompasses remediation of industrial wasteland, improvement of infertile land for agricultural production, preservation of wetlands, and restoration of disturbed areas. Land reclamation is an integral part of sustainable development which aims to reconcile economic productivity with environmental preservation. During the 1980s, significant progress was achieved in the application of advanced technologies to sustainable development projects. The goal of this international symposium was to serve as a forum to review current research and state-of-the-art technology dealing with various aspects of land reclamation, and provide an opportunity for professional interaction and exchange of information in a multi-disciplinary setting. The scope of the symposium was as broad as the topic itself. The keynote address by Professor John Cairns focused on a systems approach in land restoration projects and challenges facing scientists in global biotic impoverishment. Other topics discussed in ten mechanical sessions included development and applications of computer models, geographic information systems, remote sensing technology, salinity problems, surface and ground water monitoring, reclamation of mine areas, soil amendment methods and impacts, wetland restoration techniques, and land use planning for resource protection.

  14. [Research advances on interactions among bryophytes].

    PubMed

    Bu, Zhao-Jun; Chen, Xu; Jiang, Li-Hong; Li, Hong-Kai; Zhao, Hong-Yan

    2009-02-01

    This paper summarized the present research status and advances on the intra- and interspecific positive interaction, intra- and inter-specific competition, niche, and coexistence of bryophytes. Bryophytes are generally the dominant plants in harsh environments, and there is a trade-off between their water retention and light and nutrient resource availability. Because of the lesser importance of competition in harsh environments, the positive interaction among bryophytes is common, but the intra- and inter-specific competition among bryophytes and the competition between bryophytes and vascular plants are not rare. Competition hierarchy may exist among some bryophytes, but often changes with environments. In the process of bryophyte community formation, the random process, nature of colonization, and difference in regeneration strategy can result in the niche overlap and coexistence of bryophytes, and the niche differentiation resulted from competition is also one of the mechanisms for bryophytes coexistence. Bryophytes should not be simply classified as stress tolerated-ruderal life history strategists, and competition is still one of important factors for constructing some bryophyte communities and vegetations co-existed by bryophytes and vascular plants.

  15. Advances in Mycotoxin Research: Public Health Perspectives.

    PubMed

    Lee, Hyun Jung; Ryu, Dojin

    2015-12-01

    Aflatoxins, ochratoxins, fumonisins, deoxynivalenol, and zearalenone are of significant public health concern as they can cause serious adverse effects in different organs including the liver, kidney, and immune system in humans. These toxic secondary metabolites are produced by filamentous fungi mainly in the genus Aspergillus, Penicillium, and Fusarium. It is challenging to control the formation of mycotoxins due to the worldwide occurrence of these fungi in food and the environment. In addition to raw agricultural commodities, mycotoxins tend to remain in finished food products as they may not be destroyed by conventional processing techniques. Hence, much of our concern is directed to chronic health effects through long-term exposure to one or multiple mycotoxins from contaminated foods. Ideally risk assessment requires a comprehensive data, including toxicological and epidemiological studies as well as surveillance and exposure assessment. Setting of regulatory limits for mycotoxins is considered necessary to protect human health from mycotoxin exposure. Although advances in analytical techniques provide basic yet critical tool in regulation as well as all aspects of scientific research, it has been acknowledged that different forms of mycotoxins such as analogs and conjugated mycotoxins may constitute a significant source of dietary exposure. Further studies should be warranted to correlate mycotoxin exposure and human health possibly via identification and validation of suitable biomarkers.

  16. 2010 Summary of Advances in Autism Spectrum Disorder Research

    ERIC Educational Resources Information Center

    Interagency Autism Coordinating Committee, 2010

    2010-01-01

    As part of the Combating Autism Act of 2006, the members of the Interagency Autism Coordinating Committee (IACC) are required to develop an annual "Summary of Advances" to describe each year's top advances in autism spectrum disorder (ASD) research. These advances represent significant progress in the early diagnosis of ASD, understanding the…

  17. 77 FR 19744 - Advanced BioPhotonics, Inc., Advanced Viral Research Corp., Brantley Capital Corp., Brilliant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-02

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Advanced BioPhotonics, Inc., Advanced Viral Research Corp., Brantley Capital Corp., Brilliant... information concerning the securities of Advanced BioPhotonics, Inc. because it has not filed any...

  18. Advanced research workshop: nuclear materials safety

    SciTech Connect

    Jardine, L J; Moshkov, M M

    1999-01-28

    The Advanced Research Workshop (ARW) on Nuclear Materials Safety held June 8-10, 1998, in St. Petersburg, Russia, was attended by 27 Russian experts from 14 different Russian organizations, seven European experts from six different organizations, and 14 U.S. experts from seven different organizations. The ARW was conducted at the State Education Center (SEC), a former Minatom nuclear training center in St. Petersburg. Thirty-three technical presentations were made using simultaneous translations. These presentations are reprinted in this volume as a formal ARW Proceedings in the NATO Science Series. The representative technical papers contained here cover nuclear material safety topics on the storage and disposition of excess plutonium and high enriched uranium (HEU) fissile materials, including vitrification, mixed oxide (MOX) fuel fabrication, plutonium ceramics, reprocessing, geologic disposal, transportation, and Russian regulatory processes. This ARW completed discussions by experts of the nuclear materials safety topics that were not covered in the previous, companion ARW on Nuclear Materials Safety held in Amarillo, Texas, in March 1997. These two workshops, when viewed together as a set, have addressed most nuclear material aspects of the storage and disposition operations required for excess HEU and plutonium. As a result, specific experts in nuclear materials safety have been identified, know each other from their participation in t he two ARW interactions, and have developed a partial consensus and dialogue on the most urgent nuclear materials safety topics to be addressed in a formal bilateral program on t he subject. A strong basis now exists for maintaining and developing a continuing dialogue between Russian, European, and U.S. experts in nuclear materials safety that will improve the safety of future nuclear materials operations in all the countries involved because of t he positive synergistic effects of focusing these diverse backgrounds of

  19. Powertrain dynamics and control of a two speed dual clutch transmission for electric vehicles

    NASA Astrophysics Data System (ADS)

    Walker, Paul; Zhu, Bo; Zhang, Nong

    2017-02-01

    The purpose of this paper is to demonstrate the application of torque based powertrain control for multi-speed power shifting capable electric vehicles. To do so simulation and experimental studies of the shift transient behaviour of dual clutch transmission equipped electric vehicle powertrains is undertaken. To that end a series of power-on and power-off shift control strategies are then developed for both up and down gear shifts, taking note of the friction load requirements to maintain positive driving load for power-on shifting. A mathematical model of an electric vehicle powertrain is developed including a DC equivalent circuit model for the electric machine and multi-body dynamic model of the powertrain system is then developed and integrated with a hydraulic clutch control system model. Integral control of the powertrain is then performed through simulations on the develop powertrain system model for each of the four shift cases. These simulation results are then replicated on a full scale powertrain test rig. To evaluate the performance of results shift duration and vehicle jerk are used as metrics to demonstrate that the presented strategies are effective for shift control in electric vehicles. Qualitative comparison of both theoretical and experimental results demonstrates reasonable agreement between simulated and experimental outcomes.

  20. Advanced Materials and Solids Analysis Research Core (AMSARC)

    EPA Science Inventory

    The Advanced Materials and Solids Analysis Research Core (AMSARC), centered at the U.S. Environmental Protection Agency's (EPA) Andrew W. Breidenbach Environmental Research Center in Cincinnati, Ohio, is the foundation for the Agency's solids and surfaces analysis capabilities. ...

  1. Advanced Microwave Ferrite Research (AMFeR): Phase Four

    DTIC Science & Technology

    2009-10-15

    COVERED (From - To) 28 Dec 2006 - 30 Sep 2009 4. TITLE AND SUBTITLE Advanced Microwave Ferrite Research (AMFeR): Phase Four 5a. CONTRACT NUMBER 5b...research endeavor is to devise ferrite materials for microwave , self-biased circulator applications. To this end, the research team focused on two key...Std Z39-18 Final Report Advanced Microwave Ferrite Research (AMFeR): Phase Four Dr. Jeffrey L. Young MRC Institute/Electrical and Computer

  2. Advanced cogeneration research study: Executive summary

    NASA Technical Reports Server (NTRS)

    Bluhm, S. A.; Moore, N.; Rosenberg, L.; Slonski, M.

    1983-01-01

    This study provides a broad based overview of selected areas relevant to the development of a comprehensive Southern California Edison (SCE) advanced cogeneration project. The areas studied are: (1) Cogeneration potential in the SCE service territory; (2) Advanced cogeneration technologies; and (3) Existing cogeneration computer models. An estimated 3700 MW sub E could potentially be generated from existing industries in the Southern California Edison service territory using cogeneration technology. Of this total, current technology could provide 2600 MW sub E and advanced technology could provide 1100 MW sub E. The manufacturing sector (SIC Codes 20-39) was found to have the highest average potential for current cogeneration technology. The mining sector (SIC Codes 10-14) was found to have the highest potential for advanced technology.

  3. Ethics, Professional Expectations, and Graduate Education: Advancing Research in Kinesiology

    ERIC Educational Resources Information Center

    DePauw, Karen P.

    2009-01-01

    The university is a social institution and as such has a social responsibility to advance knowledge through research that is ultimately meaningful and beneficial to society. As we seek to advance research and graduate education in kinesiology, we must accept ethical standards and professional expectations not only as an institutional value but as…

  4. Survey of cogeneration: Advanced cogeneration research study

    NASA Technical Reports Server (NTRS)

    Slonski, M. L.

    1983-01-01

    The consumption of electricity, natural gas, or fuel oil was surveyed. The potential electricity that could be generated in the SCE service territory using cogeneration technology was estimated. It was found that an estimated 3700 MWe could potentially be generated in Southern California using cogenerated technology. It is suggested that current technology could provide 2600 MWe and advanced technology could provide 1100 MWe. Approximately 1600 MWt is considered not feasible to produce electricity with either current or advanced cogeneration technology.

  5. Real Time Energy Management Control Strategies for Hybrid Powertrains

    NASA Astrophysics Data System (ADS)

    Zaher, Mohamed Hegazi Mohamed

    In order to improve fuel efficiency and reduce emissions of mobile vehicles, various hybrid power-train concepts have been developed over the years. This thesis focuses on embedded control of hybrid powertrain concepts for mobile vehicle applications. Optimal robust control approach is used to develop a real time energy management strategy for continuous operations. The main idea is to store the normally wasted mechanical regenerative energy in energy storage devices for later usage. The regenerative energy recovery opportunity exists in any condition where the speed of motion is in opposite direction to the applied force or torque. This is the case when the vehicle is braking, decelerating, or the motion is driven by gravitational force, or load driven. There are three main concepts for regernerative energy storing devices in hybrid vehicles: electric, hydraulic, and flywheel. The real time control challenge is to balance the system power demand from the engine and the hybrid storage device, without depleting the energy storage device or stalling the engine in any work cycle, while making optimal use of the energy saving opportunities in a given operational, often repetitive cycle. In the worst case scenario, only engine is used and hybrid system completely disabled. A rule based control is developed and tuned for different work cycles and linked to a gain scheduling algorithm. A gain scheduling algorithm identifies the cycle being performed by the machine and its position via GPS, and maps them to the gains.

  6. Integrating Advance Research Directives into the European Legal Framework.

    PubMed

    Andorno, Roberto; Gennet, Eloïse; Jongsma, Karin; Elger, Bernice

    2016-04-01

    The possibility of using advance directives to prospectively consent to research participation in the event of dementia remains largely unexplored in Europe. Moreover, the legal status of advance directives for research is unclear in the European regulations governing biomedical research. The article explores the place that advance research directives have in the current European legal framework, and considers the possibility of integrating them more explicitly into the existing regulations. Special focus is placed on issues regarding informed consent, the role of proxies, and the level of acceptable risks and burdens.

  7. Integrated Advanced Energy Systems Research at IIT

    SciTech Connect

    Hamid Arastoopour

    2010-09-30

    This report consists of Two research projects; Sustainable Buildings and Hydrogen Storage. Sustainable Building Part includes: Wind and the self powered built environment by professor P. Land and his research group and experimental and computational works by professor D. Rempfer and his research group. Hydrogen Storage part includes: Hydrogen Storage Using Mg-Mixed Metal Hydrides by professor H. Arastoopour and his research team and Carbon Nanostructure as Hydrogen Storage Material by professor J. Prakash and his research team.

  8. Next Steps: Water Technology Advances (Research)

    EPA Science Inventory

    This project will focus on contaminants and their impact on health, adequate removal of contaminants from various water systems, and water and resource recovery within treatment systems. It will develop the next generation of technological advances to provide guidance in support ...

  9. Medical technology advances from space research.

    NASA Technical Reports Server (NTRS)

    Pool, S. L.

    1971-01-01

    NASA-sponsored medical R & D programs for space applications are reviewed with particular attention to the benefits of these programs to earthbound medical services and to the general public. Notable among the results of these NASA programs is an integrated medical laboratory equipped with numerous advanced systems such as digital biotelemetry and automatic visual field mapping systems, sponge electrode caps for electroencephalograms, and sophisticated respiratory analysis equipment.

  10. Advancement in LIDAR Data Collection: NASA's Experimental Airborne Advanced Research LIDAR

    NASA Technical Reports Server (NTRS)

    Riordan, Kevin; Wright, C. Wayne; Noronha, Conan

    2003-01-01

    The NASA Experimental Airborne Advanced Research LIDAR (EAARL) is a new developmental LIDAR designed to investigate and advance LIDAR techniques using a adaptive time resolved backscatter information for complex coastal research and monitoring applications. Information derived from such an advanced LIDAR system can potentially improve the ability of resource managers and policy makers to make better informed decisions. While there has been a large amount of research using LIDAR in coastal areas, most are limited in the amount of information captured from each laser pulse. The unique design of the EAARL instrument permits simultaneous acquisition of coastal environments which include subaerial bare earth topography, vegetation biomass, and bare earth beneath vegetated areas.

  11. Method and apparatus for operating a powertrain system upon detecting a stuck-closed clutch

    DOEpatents

    Hansen, R. Anthony

    2014-02-18

    A powertrain system includes a multi-mode transmission having a plurality of torque machines. A method for controlling the powertrain system includes identifying all presently applied clutches including commanded applied clutches and the stuck-closed clutch upon detecting one of the torque-transfer clutches is in a stuck-closed condition. A closed-loop control system is employed to control operation of the multi-mode transmission accounting for all the presently applied clutches.

  12. Hybrid vehicle powertrain system with power take-off driven vehicle accessory

    DOEpatents

    Beaty, Kevin D.; Bockelmann, Thomas R.; Zou, Zhanijang; Hope, Mark E.; Kang, Xiaosong; Carpenter, Jeffrey L.

    2006-09-12

    A hybrid vehicle powertrain system includes a first prime mover, a first prime mover driven power transmission mechanism having a power take-off adapted to drive a vehicle accessory, and a second prime mover. The second prime mover is operable to drive the power transmission mechanism alone or in combination with the first prime mover to provide power to the power take-off through the power transmission mechanism. The invention further includes methods for operating a hybrid vehicle powertrain system.

  13. CREST Research: Advancing the Field for Practitioners

    PubMed Central

    Mosqueda, Laura; Brandl, Bonnie; Otto, Joanne; Stiegel, Lori; Thomas, Randolph; Heisler, Candace

    2008-01-01

    An external advisory board consisting of members from the fields of geriatric internal medicine, family practice geriatrics, criminal prosecution, civil law, police force, adult protective services and victims advocacy was created to advise and guide the research conducted by the Consortium for Research in Elder Self-neglect of Texas (CREST). This panel of experts performed site visits and facilitated the research through responses to biweekly facts sheets and quarterly conference calls. This paper provides the perspective of five of the board members regarding the research findings that were presented at the CREST National Conference in 2006. The discussions outline the successes of the CREST research, describe obstacles and the necessary next steps for continuance of the scientific exploration of this syndrome, and highlight the practice implications of the current and proposed research. PMID:19016972

  14. Research opportunities to advance solar energy utilization.

    PubMed

    Lewis, Nathan S

    2016-01-22

    Major developments, as well as remaining challenges and the associated research opportunities, are evaluated for three technologically distinct approaches to solar energy utilization: solar electricity, solar thermal, and solar fuels technologies. Much progress has been made, but research opportunities are still present for all approaches. Both evolutionary and revolutionary technology development, involving foundational research, applied research, learning by doing, demonstration projects, and deployment at scale will be needed to continue this technology-innovation ecosystem. Most of the approaches still offer the potential to provide much higher efficiencies, much lower costs, improved scalability, and new functionality, relative to the embodiments of solar energy-conversion systems that have been developed to date.

  15. Advanced research in solar energy storage

    NASA Astrophysics Data System (ADS)

    Luft, W.

    1983-01-01

    This paper gives an overview of the Solar Energy Storage Program at the Solar Energy Research Institute. The program provides research, systems analyses, and economic assessments of thermal and thermochemical energy storage and transport. Current activities include experimental research into very high temperature (above 800 C) thermal energy storage and assessment of novel thermochemical energy storage and transport systems. The applications for such high-temperature storage are thermochemical processes, solar thermal-electric power generation, cogeneration of heat and electricity, industrial process heat, and thermally regenerative electrochemical systems. The research results for five high-temperature thermal energy storage technologies and two thermochemical systems are described.

  16. Ozone Research with Advanced Cooperative Lidar Experiment (ORACLE) Implementation Study

    NASA Technical Reports Server (NTRS)

    Stadler, John H.; Browell, Edward V.; Ismail, Syed; Dudelzak, Alexander E.; Ball, Donald J.

    1998-01-01

    New technological advances have made possible new active remote sensing capabilities from space. Utilizing these technologies, the Ozone Research with Advanced Cooperative Lidar Experiment (ORACLE) will provide high spatial resolution measurements of ozone, clouds and aerosols in the stratosphere and lower troposphere. Simultaneous measurements of ozone, clouds and aerosols will assist in the understanding of global change, atmospheric chemistry and meteorology.

  17. Intervention Research in Social Work: Recent Advances and Continuing Challenges

    ERIC Educational Resources Information Center

    Fraser, Mark W.

    2004-01-01

    The purpose of this article is to review substantive and methodological advances in interventive research. Three substantive advances are discussed: (a) the growing use of a risk factor perspective, (b) the emergence of practice-relevant micro social theories, and (c) the increased acceptance of structured treatment protocols and manual. In…

  18. Addressing Risks to Advance Mental Health Research

    PubMed Central

    Iltis, Ana S.; Misra, Sahana; Dunn, Laura B.; Brown, Gregory K.; Campbell, Amy; Earll, Sarah A.; Glowinski, Anne; Hadley, Whitney B.; Pies, Ronald; DuBois, James M.

    2015-01-01

    Objective Risk communication and management are essential to the ethical conduct of research, yet addressing risks may be time consuming for investigators and institutional review boards (IRBs) may reject study designs that appear too risky. This can discourage needed research, particularly in higher risk protocols or those enrolling potentially vulnerable individuals, such as those with some level of suicidality. Improved mechanisms for addressing research risks may facilitate much needed psychiatric research. This article provides mental health researchers with practical approaches to: 1) identify and define various intrinsic research risks; 2) communicate these risks to others (e.g., potential participants, regulatory bodies, society); 3) manage these risks during the course of a study; and 4) justify the risks. Methods As part of a National Institute of Mental Health (NIMH)-funded scientific meeting series, a public conference and a closed-session expert panel meeting were held on managing and disclosing risks in mental health clinical trials. The expert panel reviewed the literature with a focus on empirical studies and developed recommendations for best practices and further research on managing and disclosing risks in mental health clinical trials. IRB review was not required because there were no human subjects. The NIMH played no role in developing or reviewing the manuscript. Results Challenges, current data, practical strategies, and topics for future research are addressed for each of four key areas pertaining to management and disclosure of risks in clinical trials: identifying and defining risks, communicating risks, managing risks during studies, and justifying research risks. Conclusions Empirical data on risk communication, managing risks, and the benefits of research can support the ethical conduct of mental health research and may help investigators better conceptualize and confront risks and to gain IRB approval. PMID:24173618

  19. Optimal control of a repowered vehicle: Plug-in fuel cell against plug-in hybrid electric powertrain

    SciTech Connect

    Tribioli, L. Cozzolino, R.; Barbieri, M.

    2015-03-10

    This paper describes two different powertrain configurations for the repowering of a conventional vehicle, equipped with an internal combustion engine (ICE). A model of a mid-sized ICE-vehicle is realized and then modified to model both a parallel plug-in hybrid electric powertrain and a proton electrolyte membrane (PEM) fuel cell (FC) hybrid powertrain. The vehicle behavior under the application of an optimal control algorithm for the energy management is analyzed for the different scenarios and results are compared.

  20. Special Education Research Advances Knowledge in Education

    ERIC Educational Resources Information Center

    Vaughn, Sharon; Swanson, Elizabeth A.

    2015-01-01

    Research in special education has yielded beneficial outcomes for students with disabilities as well as typical achieving students. The authors provide examples of the valuable knowledge special education research has generated, including the elements of response to intervention (e.g., screening and progress monitoring), instructional practices…

  1. Advanced technology airfoil research, volume 2. [conferences

    NASA Technical Reports Server (NTRS)

    1979-01-01

    A comprehensive review of airfoil research is presented. The major thrust of the research is in three areas: development of computational aerodynamic codes for airfoil analysis and design, development of experimental facilities and test techniques, and all types of airfoil applications.

  2. Advancing Administrative Supports for Research Development

    ERIC Educational Resources Information Center

    Briar-Lawson, Katharine; Korr, Wynne; White, Barbara; Vroom, Phyllis; Zabora, James; Middleton, Jane; Shank, Barbara; Schatz, Mona

    2008-01-01

    Research administrative supports must parallel and reinforce faculty initiatives in research grant procurement. This article features several types of developments that draw on presentations at the National Association of Deans and Directors of Schools of Social Work meetings. Key changes in social work programs are addressed, including the…

  3. Strategy to Promote Active Learning of an Advanced Research Method

    ERIC Educational Resources Information Center

    McDermott, Hilary J.; Dovey, Terence M.

    2013-01-01

    Research methods courses aim to equip students with the knowledge and skills required for research yet seldom include practical aspects of assessment. This reflective practitioner report describes and evaluates an innovative approach to teaching and assessing advanced qualitative research methods to final-year psychology undergraduate students. An…

  4. Advancements in Research Synthesis Methods: From a Methodologically Inclusive Perspective

    ERIC Educational Resources Information Center

    Suri, Harsh; Clarke, David

    2009-01-01

    The dominant literature on research synthesis methods has positivist and neo-positivist origins. In recent years, the landscape of research synthesis methods has changed rapidly to become inclusive. This article highlights methodologically inclusive advancements in research synthesis methods. Attention is drawn to insights from interpretive,…

  5. Symposium on research advances in clinical PET. Final performance report

    SciTech Connect

    J. Michael McGehee

    1992-01-01

    The Institute for Clinical PET and the U.S. Department of Energy (DOE) co-sponsored a symposium entitled 'Research in PET: International and Institutional Perspectives' that highlighted the activities of many leading investigators in the U.S. and throughout the world. Research programs at the DOE were discussed as were potential directions of PET research. International as well as institutional perspectives on PET research were presented. This symposium was successful in reaching those interested in research advances of clinical PET.

  6. Prostate Cancer Stem Cells: Research Advances

    PubMed Central

    Jaworska, Dagmara; Król, Wojciech; Szliszka, Ewelina

    2015-01-01

    Cancer stem cells have been defined as cells within a tumor that possesses the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor. Experimental evidence showed that these highly tumorigenic cells might be responsible for initiation and progression of cancer into invasive and metastatic disease. Eradicating prostate cancer stem cells, the root of the problem, has been considered as a promising target in prostate cancer treatment to improve the prognosis for patients with advanced stages of the disease. PMID:26593898

  7. Optimally Controlled Flexible Fuel Powertrain System

    SciTech Connect

    Hakan Yilmaz; Mark Christie; Anna Stefanopoulou

    2010-12-31

    The primary objective of this project was to develop a true Flex Fuel Vehicle capable of running on any blend of ethanol from 0 to 85% with reduced penalty in usable vehicle range. A research and development program, targeting 10% improvement in fuel economy using a direct injection (DI) turbocharged spark ignition engine was conducted. In this project a gasoline-optimized high-technology engine was considered and the hardware and configuration modifications were defined for the engine, fueling system, and air path. Combined with a novel engine control strategy, control software, and calibration this resulted in a highly efficient and clean FFV concept. It was also intended to develop robust detection schemes of the ethanol content in the fuel integrated with adaptive control algorithms for optimized turbocharged direct injection engine combustion. The approach relies heavily on software-based adaptation and optimization striving for minimal modifications to the gasoline-optimized engine hardware system. Our ultimate objective was to develop a compact control methodology that takes advantage of any ethanol-based fuel mixture and not compromise the engine performance under gasoline operation.

  8. Development of a KT driving cycle for UMT PHEV powertrain

    NASA Astrophysics Data System (ADS)

    Atiq, W. H.; Haezah, M. N.; Norbakyah, J. S.; Salisa, A. R.

    2015-12-01

    Driving cycles were identified as one of the core sources that contribute to develop the powertrain for vehicle. Plug-in hybrid electric vehicles (PHEVs) are the future transport for next generation. Compared to conventional internal combustion engine vehicle, hybrid and electric vehicle can improve fuel economy and reduce green house gases. This paper describes a development of Kuala Terengganu driving cycle for Universiti Malaysia Terengganu PHEV. Car speed-time data along the two selected fixed route is obtained by using on-board technique which is Global Positioning System, GPS. The developed driving cycle contains a 1050s speed time series, with a distance of 2.17 km, and an average and a maximum speed of 20.67 km/h and 61.47 km/h, respectively. The results obtained from this analysis are within reasonable range and satisfactory.

  9. Advancing Global Cancer Research @ AACR 2015

    Cancer.gov

    Research Priorities for NCI’s Center for Global Health' and included presentations on our mission, objectives, currently funded programs, and future programs given by Dr. Lisa Stevens and Paul Pearlman, as well as three special presentations by NCI grantees.

  10. NIAAA: Advancing Alcohol Research for 40 Years

    PubMed Central

    Warren, Kenneth R.; Hewitt, Brenda G.

    2010-01-01

    The National Institute on Alcohol Abuse and Alcoholism (NIAAA) has been the lead Federal agency responsible for scientific research on alcohol and its effects for 40 years. During that time, NIAAA has conducted and funded groundbreaking research, distilled and disseminated those research findings to a broad audience, and ultimately improved public health. Among NIAAA’s many significant contributions are the National Epidemiologic Survey on Alcohol and Related Conditions, the largest survey ever conducted on alcohol and associated psychiatric and medical conditions; investment in research to identify the genes underlying vulnerability to alcoholism; creation of the Collaborative Studies on Genetics of Alcoholism, a study of the genetics of alcoholism in a human population; leadership in exploring the effects of alcohol on fetal development and on a variety of diseases and organ systems; fostering alcoholism treatment, including supporting a medications development program that has funded more than 30 Phase 2 trials and 15 human laboratory studies; international collaborations and work across the National Institutes of Health; influential research on preventing alcohol problems through community programs as well as policy changes; and the translation of research findings to everyday practice, including the production of award-winning clinician training materials. PMID:23579932

  11. INEEL Advanced Radiotherapy Research Program Annual Report 2001

    SciTech Connect

    Venhuizen, James R.

    2002-04-30

    This report summarizes the major activities and accomplishments of the Idaho National Engineering and Environmental Laboratory (INEEL) Advanced Radiotherapy Research Program for calendar year 2001. Applications of supportive research and development, as well as technology deployment in the fields of chemistry, radiation physics and dosimetry, and neutron source design and demonstration are described. Contributions in the fields of physics and biophysics include development of advanced patient treatment planning software, feasibility studies of accelerator neutron source technology for Neutron Capture Therapy (NCT), and completion of major modifications to the research reactor at Washington State University to produce an epithermal-neutron beam for NCT research applications.

  12. INEEL Advanced Radiotherapy Research Program Annual Report 2001

    SciTech Connect

    Venhuizen, James Robert

    2002-04-01

    This report summarizes the major activities and accomplishments of the Idaho National Engineering and Environmental Laboratory (INEEL) Advanced Radiotherapy Research Program for calendar year 2001. Applications of supportive research and development, as well as technology deployment in the fields of chemistry, radiation physics and dosimetry, and neutron source design and demonstration are described. Contributions in the fields of physics and biophysics include development of advanced patient treatment planning software, feasibility studies of accelerator neutron source technology for Neutron Capture Therapy (NCT), and completion of major modifications to the research reactor at Washington State University to produce an epithermal-neutron beam for NCT research applications.

  13. Integrating ergonomics into production system development--the Volvo Powertrain case.

    PubMed

    Neumann, W Patrick; Ekman, Marianne; Winkel, Jørgen

    2009-05-01

    Understanding the barriers and assists to integrating ergonomics into production system design remains a research issue. An action research case study at Volvo Powertrain/Sweden was conducted. Researchers worked collaboratively with the firm in efforts to improve the company's ability to handle ergonomics in their daily work of improving and developing production systems. Researchers observed and reflected collectively on the change process using field notes and recordings to support their observations. Observed integration barriers included both individual level issues like life events, and organisational aspects such as communication barriers between groups or assignment of tasks to people not involved in decision-making. Observed assists included the 'political reflective navigation' (c.f. Broberg, O., Hermund, I., 2004. The OHS consultant as a 'political reflective navigator' in technological change processes. International Journal of Industrial Ergonomics 33 (4), 315-326) by the project owner to find new ways to overcome barriers and anchor ergonomics into the organisation. While special 'ergonomics' groups did not survive long, progress was observed in including ergonomics in regular design groups. A cross-functional workshop that fostered discussion across organisational boundaries helped shift focus from retrofitting systems to future production systems and improve engagement of engineering teams. Progress was marked by both success and setbacks and full integration appears to require more than 2 years time. It is concluded that support by senior managers should include succession planning for personnel that are key to the change effort.

  14. Educating Scientifically - Advances in Physics Education Research

    ScienceCinema

    Finkelstein, Noah [University of Colorado, Colorado, USA

    2016-07-12

    It is now fairly well documented that traditionally taught, large-scale introductory physics courses fail to teach our students the basics. In fact, often these same courses have been found to teach students things we do not want. Building on a tradition of research in physics, the physics education research community has been researching the effects of educational practice and reforms at the undergraduate level for many decades. From these efforts and those within the fields of education, cognitive science, and psychology we have learned a great deal about student learning and environments that support learning for an increasingly diverse population of students in the physics classroom. This talk will introduce some of the ideas from physics education research, discuss a variety of effective classroom practices/ surrounding educational structures, and begin to examine why these do (and do not) work. I will present both a survey of physics education research and some of the exciting theoretical and experimental developments emerging from the University of Colorado.

  15. Conceptualizing and Advancing Research Networking Systems

    PubMed Central

    SCHLEYER, TITUS; BUTLER, BRIAN S.; SONG, MEI; SPALLEK, HEIKO

    2013-01-01

    Science in general, and biomedical research in particular, is becoming more collaborative. As a result, collaboration with the right individuals, teams, and institutions is increasingly crucial for scientific progress. We propose Research Networking Systems (RNS) as a new type of system designed to help scientists identify and choose collaborators, and suggest a corresponding research agenda. The research agenda covers four areas: foundations, presentation, architecture, and evaluation. Foundations includes project-, institution- and discipline-specific motivational factors; the role of social networks; and impression formation based on information beyond expertise and interests. Presentation addresses representing expertise in a comprehensive and up-to-date manner; the role of controlled vocabularies and folksonomies; the tension between seekers’ need for comprehensive information and potential collaborators’ desire to control how they are seen by others; and the need to support serendipitous discovery of collaborative opportunities. Architecture considers aggregation and synthesis of information from multiple sources, social system interoperability, and integration with the user’s primary work context. Lastly, evaluation focuses on assessment of collaboration decisions, measurement of user-specific costs and benefits, and how the large-scale impact of RNS could be evaluated with longitudinal and naturalistic methods. We hope that this article stimulates the human-computer interaction, computer-supported cooperative work, and related communities to pursue a broad and comprehensive agenda for developing research networking systems. PMID:24376309

  16. Educating Scientifically: Advances in Physics Education Research

    SciTech Connect

    Finkelstein, Noah

    2007-05-16

    It is now fairly well documented that traditionally taught, large-scale introductory physics courses fail to teach our students the basics. In fact, often these same courses have been found to teach students things we do not want. Building on a tradition of research in physics, the physics education research community has been researching the effects of educational practice and reforms at the undergraduate level for many decades. From these efforts and those within the fields of education, cognitive science, and psychology we have learned a great deal about student learning and environments that support learning for an increasingly diverse population of students in the physics classroom. This talk will introduce some of the ideas from physics education research, discuss a variety of effective classroom practices/ surrounding educational structures, and begin to examine why these do (and do not) work. I will present both a survey of physics education research and some of the exciting theoretical and experimental developments emerging from the University of Colorado.

  17. Educating Scientifically - Advances in Physics Education Research

    SciTech Connect

    Finkelstein, Noah

    2007-05-16

    It is now fairly well documented that traditionally taught, large-scale introductory physics courses fail to teach our students the basics. In fact, often these same courses have been found to teach students things we do not want. Building on a tradition of research in physics, the physics education research community has been researching the effects of educational practice and reforms at the undergraduate level for many decades. From these efforts and those within the fields of education, cognitive science, and psychology we have learned a great deal about student learning and environments that support learning for an increasingly diverse population of students in the physics classroom. This talk will introduce some of the ideas from physics education research, discuss a variety of effective classroom practices/ surrounding educational structures, and begin to examine why these do (and do not) work. I will present both a survey of physics education research and some of the exciting theoretical and experimental developments emerging from the University of Colorado.

  18. Advanced energy projects; FY 1995 research summaries

    SciTech Connect

    1995-09-01

    The AEP Division supports projects to explore novel energy-related concepts which are typically at an early stage of scientific development, and high-risk, exploratory concepts. Topical areas presently receiving support are: novel materials for energy technology, renewable and biodegradable materials, exploring uses of new scientific discoveries, alternate pathways to energy efficiency, alternative energy sources, and innovative approaches to waste treatment and reduction. There were 46 research projects during FY 1995; ten were initiated during that fiscal year. The summaries are separated into grant and laboratory programs, and small business innovation research programs.

  19. Advances in Education Research, Winter 1999.

    ERIC Educational Resources Information Center

    Advances in Education Research, 1999

    1999-01-01

    This volume presents selected articles related to the impact of early intervention programs. This is part of a two volume set designed to showcase some of the best cutting edge research in these programs. This volume focuses specifically on aspects of the programs that have proven to be most successful in helping students and meeting programmatic…

  20. Advancing Research on the Community College

    ERIC Educational Resources Information Center

    Bers, Trudy H.

    2007-01-01

    Arthur M. Cohen and his colleagues at the Center for the Study of Community Colleges have made significant and broad contributions to the scholarly literature and empirical research about community colleges. Although Cohen's interests are comprehensive and his writings touch on multiple issues associated with community colleges, his empirical work…

  1. Advanced Energy Projects: FY 1993, Research summaries

    SciTech Connect

    Not Available

    1993-09-01

    AEP has been supporting research on novel materials for energy technology, renewable and biodegradable materials, new uses for scientific discoveries, alternate pathways to energy efficiency, alternative energy sources, innovative approaches to waste treatment and reduction, etc. The summaries are grouped according to projects active in FY 1993, Phase I SBIR projects, and Phase II SBIR projects. Investigator and institutional indexes are included.

  2. Advances in Bayesian Modeling in Educational Research

    ERIC Educational Resources Information Center

    Levy, Roy

    2016-01-01

    In this article, I provide a conceptually oriented overview of Bayesian approaches to statistical inference and contrast them with frequentist approaches that currently dominate conventional practice in educational research. The features and advantages of Bayesian approaches are illustrated with examples spanning several statistical modeling…

  3. Advances in Child Development: Theory and Research.

    ERIC Educational Resources Information Center

    Nesdale, Andrew R., Ed.; And Others

    This book consists of 31 papers focusing on aspects of child development. Mainly reports of research, papers are grouped topically into four sections dealing respectively with perceptual, language/communication, cognitive, and social development. Most of the nine papers in section 1 focus on the perceptual development of infants. Topics include…

  4. Advances in Music-Reading Research

    ERIC Educational Resources Information Center

    Gudmundsdottir, Helga Rut

    2010-01-01

    The purpose of this paper is to construct a comprehensive review of the research literature in the reading of western staff notation. Studies in music perception, music cognition, music education and music neurology are cited. The aim is to establish current knowledge in music-reading acquisition and what is needed for further progress in this…

  5. Advances in Design-Based Research

    ERIC Educational Resources Information Center

    Svihla, Vanessa

    2014-01-01

    Design-based research (DBR) is a core methodology of the Learning Sciences. Historically rooted as a movement away from the methods of experimental psychology, it is a means to develop "humble" theory that takes into account numerous contextual effects for understanding how and why a design supported learning. DBR involves iterative…

  6. Load research manual. Volume 3. Load research for advanced technologies

    SciTech Connect

    Brandenburg, L.; Clarkson, G.; Grund, Jr., C.; Leo, J.; Asbury, J.; Brandon-Brown, F.; Derderian, H.; Mueller, R.; Swaroop, R.

    1980-11-01

    This three-volume manual presents technical guidelines for electric utility load research. Special attention is given to issues raised by the load data reporting requirements of the Public Utility Regulatory Policies Act of 1978 and to problems faced by smaller utilities that are initiating load research programs. The manual includes guides to load research literature and glossaries of load research and statistical terms. In Volume 3, special load research procedures are presented for solar, wind, and cogeneration technologies.

  7. Research advances on transgenic plant vaccines.

    PubMed

    Han, Mei; Su, Tao; Zu, Yuan-Gang; An, Zhi-Gang

    2006-04-01

    In recent years, with the development of genetics molecular biology and plant biotechnology, the vaccination (e.g. genetic engineering subunit vaccine, living vector vaccine, nucleic acid vaccine) programs are taking on a prosperous evolvement. In particular, the technology of the use of transgenic plants to produce human or animal therapeutic vaccines receives increasing attention. Expressing vaccine candidates in vegetables and fruits open up a new avenue for producing oral/edible vaccines. Transgenic plant vaccine disquisitions exhibit a tempting latent exploiting foreground. There are a lot of advantages for transgenic plant vaccines, such as low cost, easiness of storage, and convenient immune-inoculation. Some productions converged in edible tissues, so they can be consumed directly without isolation and purification. Up to now, many transgenic plant vaccine productions have been investigated and developed. In this review, recent advances on plant-derived recombinant protein expression systems, infectious targets, and delivery systems are presented. Some issues of high concern such as biosafety and public health are also discussed. Special attention is given to the prospects and limitations on transgenic plant vaccines.

  8. [Research advances in forest soil respiration].

    PubMed

    Luan, Junwei; Xiang, Chenghua; Luo, Zongshi; Gong, Yuanbo

    2006-12-01

    Among the methods of measuring forest soil respiration, infrared CO2 analysis is the optimal one so far. Comparing with empirical model, the process-based model in simulating the production and transportation of soil CO2 has the advantage of considering the biological and physical processes of soil respiration. Generally, soil respiration is positively correlated with soil temperature and moisture, but there are still many uncertainties about the relationships between soil respiration and forest management activities such as firing, cutting, and fertilization. The relationships of soil respiration with vegetation type and soil microbial biomass, as well as the spatial heterogeneity of soil respiration, are the hotspots in recent researches. Some issues and future development in forest soil respiration research were discussed in this paper.

  9. Frontiers of research in advanced computations

    SciTech Connect

    1996-07-01

    The principal mission of the Institute for Scientific Computing Research is to foster interactions among LLNL researchers, universities, and industry on selected topics in scientific computing. In the area of computational physics, the Institute has developed a new algorithm, GaPH, to help scientists understand the chemistry of turbulent and driven plasmas or gases at far less cost than other methods. New low-frequency electromagnetic models better describe the plasma etching and deposition characteristics of a computer chip in the making. A new method for modeling realistic curved boundaries within an orthogonal mesh is resulting in a better understanding of the physics associated with such boundaries and much quicker solutions. All these capabilities are being developed for massively parallel implementation, which is an ongoing focus of Institute researchers. Other groups within the Institute are developing novel computational methods to address a range of other problems. Examples include feature detection and motion recognition by computer, improved monitoring of blood oxygen levels, and entirely new models of human joint mechanics and prosthetic devices.

  10. Research priorities and history of advanced composite compression testing

    NASA Technical Reports Server (NTRS)

    Baumann, K. J.

    1981-01-01

    Priorities for standard compression testing research in advanced laminated fibrous composite materials are presented along with a state of the art survey (completed in 1979) including history and commentary on industrial test methods. Historically apparent research priorities and consequent (lack of) progress are supporting evidence for newly derived priorities.

  11. Broadening horizons: engaging advanced practice nursing students in faculty research.

    PubMed

    Weiss, Josie A

    2009-01-01

    Inviting advanced practice nursing students to participate in faculty research can be an innovative way to interest students in using current evidence as the basis for their practice. The author discusses strategies for effectively engaging graduate nursing students into research projects in ways that broaden the students' perspectives and strengthen their healthcare decision-making skills.

  12. Clinical Research Informatics: Recent Advances and Future Directions

    PubMed Central

    2015-01-01

    Summary Objectives To summarize significant developments in Clinical Research Informatics (CRI) over the past two years and discuss future directions. Methods Survey of advances, open problems and opportunities in this field based on exploration of current literature. Results Recent advances are structured according to three use cases of clinical research: Protocol feasibility, patient identification/recruitment and clinical trial execution. Discussion CRI is an evolving, dynamic field of research. Global collaboration, open metadata, content standards with semantics and computable eligibility criteria are key success factors for future developments in CRI. PMID:26293865

  13. Advances in nanostructured permanent magnets research

    SciTech Connect

    Poudyal, N; Liu, JP

    2012-12-14

    This paper reviews recent developments in research in nanostructured permanent magnets ( hard magnetic materials) with emphasis on bottom-up approaches to fabrication of hard/soft nanocomposite bulk magnets. Theoretical and experimental findings on the effects of soft phase and interface conditions on interphase exchange interactions are given. Synthesis techniques for hard magnetic nanoparticles, including chemical solution methods, surfactant-assisted ball milling and other physical deposition methods are reviewed. Processing and magnetic properties of warm compacted and plastically deformed bulk magnets with nanocrystalline morphology are discussed. Prospects of producing bulk anisotropic hard/soft nanocomposite magnets are presented.

  14. Advances in fog microphysics research in China

    NASA Astrophysics Data System (ADS)

    Liu, Duanyang; Li, Zihua; Yan, Wenlian; Li, Yi

    2017-02-01

    Fog microphysical research in China based on field experiments obtained many important results in recent 50 years. With the fast development of China's economy, urbanization in the last 30 years, special features of fog microphysical structure also appeared, which did not appear in other countries. This article reviews the fog microphysical research around China, and introduces the effect of urbanization on fog microphysical structure and the microphysical processes as well as macroscopic conditions of radiation fog droplet spectral broadening. Urbanization led to an increase in fog droplet number concentration but decreases in fog liquid water content (LWC) and fog droplet size, as well as a decrease in visibility in large cities. Observations show that the radiation fog could be divided into wide-spectrum one, which is all extremely dense fog with the spectral width more than 40 μm, and narrow-spectrum one, most of which is dense fog with the spectral width less than 22 μm, according to droplet spectral distribution. During developing from dense fog to extremely dense fog, the widespectrum radiation fog is characterized by explosive deepening, that is, within a very short time (about 30 min), the droplet concentration increase by about one order of magnitude, droplet spectral broadening across 20 μm, generally up to 30-40 μm, or even 50 μm. As a result, water content increased obviously, visibility decreased to less than 50 m, when dense fog became extremely dense fog.

  15. Recent advances in organ microcirculation research.

    PubMed

    Tsuchiya, M; Oda, M

    1987-01-01

    This review article dealt with progress in the research of gastroenterological organ microcirculation in Japan. It must be emphasized that this remarkable progress particularly in intravital microcirculatory observations at organ level is attributable to great improvement of microscopic devices combined with computerized system, development of new techniques for measuring microcirculatory blood flow and pioneering of a variety of fluorescent and isotope-labelled tracers. Little attention has been directed toward the fact that microvascular manifestations are perhaps the earliest signs of "cells and tissues" dysfunction in disease processes. The microvasculature undergoes a substantial remodeling not only in vascular wall structures, but also in network characteristics themselves especially in chronic disease. Those microvascular alterations in an organ system, which primarily originate in adaptations to the microenvironmental changes, would lead to the chronicity and self-perpetuation of disease. As has been noted in the IVth World Congress for Microcirculation organized by the Japanese Society for Microcirculation, which was held in Tokyo, July 26-30, 1987, further progress has been made in the research of organ microcirculation in the gastroenterological and other fields. It is the cornerstone for better understanding of the pathogenesis of organ diseases to clarify the earliest alterations in the microvasculature of an organ system from a combined aspect of microhemo- and microlymphocirculation using the newly developed techniques for microcirculation study.

  16. Recent advances on Ilex paraguariensis research: minireview.

    PubMed

    Bracesco, N; Sanchez, A G; Contreras, V; Menini, T; Gugliucci, A

    2011-07-14

    Ilex paraguariensis dried and minced leaves are made into a brewed tea, prepared in a sui generis manner by large populations in South America, having evolved from a tea drunk by the Guarani ethnic group to a beverage that has a social and almost ritualistic role in some South American modern societies. It is used both as a source of caffeine, in lieu or in parallel with tea and coffee, but also as a therapeutic agent for its alleged pharmacological properties. Although with some exceptions, research on biomedical properties of this herb has had a late start and strongly lags behind the impressive amount of literature on green tea and coffee. However, in the past 15 years, there was a several-fold increase in the literature studying Ilex paraguariensis properties showing effects such as antioxidant properties in chemical models and ex vivo lipoprotein studies, vaso-dilating and lipid reduction properties, antimutagenic effects, controversial association with oropharyngeal cancer, anti-glycation effects and weight reduction properties. Lately, promising results from human intervention studies have surfaced and the literature offers several developments on this area. The aim of this review is to provide a concise summary of the research published in the past three years, with an emphasis on translational studies, inflammation and lipid metabolism. Ilex paraguariensis reduces LDL-cholesterol levels in humans with Ilex paraguariensis dyslipoproteinemia and the effect is synergic with that of statins. Plasma antioxidant capacity as well as expression of antioxidant enzymes is positively modulated by intervention with Ilex paraguariensis in human cohorts. A review on the evidence implicating Ilex paraguariensis heavy consumption with some neoplasias show data that are inconclusive but indicate that contamination with alkylating agents during the drying process of the leaves should be avoided. On the other hand, several new studies confirm the antimutagenic effects of

  17. Research on geothermal chemistry and advanced instrumentation

    NASA Astrophysics Data System (ADS)

    Robertus, R. J.; Shannon, D. W.; Sullivan, R. G.; Kindle, C. H.; Pool, K. H.

    1985-09-01

    Research at the Pacific Northwest Laboratory (PNL) focuses on long-term geothermal power plant reliability. Past work concentrated on development of continuous high-temperature probes for monitoring process variables. PNL also completed a comprehensive handbook of brine treatment processes as they relate to injection well longevity. A recently completed study analyzed corrosion in the hydrocarbon system of a binary cycle plant. Over the two-year monitoring period, corrosion rates were less than 1 MPY in any part of the hydrocarbon system. The system was kept completely dry so the rates seem reasonable. Present projects include: (1) determination of gas breakout conditions at the Herber Binary Demonstration Plant operated by San Diego Gas and Electric Company; (2) generation of water mixing solubility data; (3) installation of prototype leak detectors at the Herber Plant; and (4) evaluation of state-of-the-art particle counters.

  18. Advances in the CIS research at NREL

    SciTech Connect

    Ramanathan, K.; Bhattacharya, R.N.; Granata, J.; Webb, J.; Niles, D.; Contreras, M.A.; Wiesner, H.; Hasoon, F.S.; Noufi, R.

    1997-12-31

    This paper summarizes the research of the CIS Team at NREL in three major areas: absorber deposition; understanding the role of chemical bath deposited (CBD) CdS in CIS junctions; and in the development of devices without CdS. Low cost, scaleable processes chosen for absorber fabrication include sputtering, electrodeposition (ED), and close spaced sublimation (CSS). The interaction between the CBD and the CIS has been investigated and the results show that Cd might be instrumental in shaping the interface. The authors have also developed a process to fabricate a 13.5% efficiency ZnO/CuInGaSe{sub 2} device without CdS or other buffer layers.

  19. Advanced moisture sensor research and development

    SciTech Connect

    De Los Santos, A.

    1992-10-31

    During this period, testing of the system continued at the American Fructose (AF) plant in Dimmitt, Texas. Testing at the first two sites (dryer output and dryer input) was completed. Following the testing at the second site, the sensor was returned to the Southwest Research Institute (SwRI) laboratories for modifications and for fitting of the additional components required to allow sampling of the material to be measured at the third site. These modifications were completed during this reporting period, and the system is scheduled to be installed at the third site (Rotary Vacuum Filter output) early in the next period. Laboratory measurements of corn germ (to be measured at the fourth site) and a variety of fruits and vegetables (one of which will be measured at the fifth site) have also continued during this period.

  20. Advances in Biomarker Research in Parkinson's Disease.

    PubMed

    Mehta, Shyamal H; Adler, Charles H

    2016-01-01

    Parkinson's disease (PD) is the second most common neurodegenerative disease, and the numbers are projected to double in the next two decades with the increase in the aging population. An important focus of current research is to develop interventions to slow the progression of the disease. However, prerequisites to it include the development of reliable biomarkers for early diagnosis which would identify at-risk groups and disease progression. In this review, we present updated evidence of already known clinical biomarkers (such as hyposmia and rapid eye movement (REM) sleep behavior disorder (RBD)) and neuroimaging biomarkers, as well as newer possible markers in the blood, CSF, and other tissues. While several promising candidates and methods to assess these biomarkers are on the horizon, it is becoming increasingly clear that no one candidate will clearly fulfill all the roles as a single biomarker. A multimodal and combinatorial approach to develop a battery of biomarkers will likely be necessary in the future.

  1. idaho Accelerator Center Advanced Fuel Cycle Research

    SciTech Connect

    Wells, Douglas; Dale, Dan

    2011-10-20

    The technical effort has been in two parts called; Materials Science and Instrumentation Development. The Materials Science technical program has been based on a series of research and development achievements in Positron-Annihilation Spectroscopy (PAS) for defect detection in structural materials. This work is of particular importance in nuclear power and its supporting systems as the work included detection of defects introduced by mechanical and thermal phenomena as well as those caused by irradiation damage. The second part of the program has focused on instrumentation development using active interrogation techniques supporting proliferation resistant recycling methodologies and nuclear material safeguards. This effort has also lead to basic physics studies of various phenomena relating to photo-fission. Highlights of accomplishments and facility improvement legacies in these areas over the program period include

  2. Expert Meeting Report: Advanced Envelope Research for Factory Built Housing

    SciTech Connect

    Levy, E.; Mullens, M.; Tompos, E.; Kessler, B.; Rath, P.

    2012-04-01

    This report provides information about the expert meeting on advanced envelope research for factory built housing, hosted by the ARIES Collaborative on October 11, 2011, in Phoenix, Arizona. The goals of this meeting were to provide a comprehensive solution to the use of three previously selected advanced alternatives for factory-built wall construction, assess each option focusing on major issues relating to viability and commercial potential, and determine additional steps are required to reach this potential.

  3. Expert Meeting Report: Advanced Envelope Research for Factory Built Housing

    SciTech Connect

    Levy, E.; Mullens, M.; Tompos, E.; Kessler, B.; Rath, P.

    2012-04-01

    This report provides information about the Building America expert meeting on advanced envelope research for factory built housing, hosted by the ARIES Collaborative on October 11, 2011, in Phoenix, Arizona. The goals of this meeting were to provide a comprehensive solution to the use of three previously selected advanced alternatives for factory-built wall construction, assess each option focusing on major issues relating to viability and commercial potential, and determine additional steps are required to reach this potential.

  4. Research advancements in palm oil nutrition.

    PubMed

    May, Choo Yuen; Nesaretnam, Kalanithi

    2014-10-01

    Palm oil is the major oil produced, with annual world production in excess of 50 million tonnes. About 85% of global palm oil produced is used in food applications. Over the past three decades, research on nutritional benefits of palm oil have demonstrated the nutritional adequacy of palm oil and its products, and have resulted in transitions in the understanding these attributes. Numerous studies have demonstrated that palm oil was similar to unsaturated oils with regards to effects on blood lipids. Palm oil provides a healthy alternative to trans-fatty acid containing hydrogenated fats that have been demonstrated to have serious deleterious effects on health. The similar effects of palm oil on blood lipids, comparable to other vegetable oils could very well be due to the structure of the major triglycerides in palm oil, which has an unsaturated fatty acid in the stereospecific numbers (sn)-2 position of the glycerol backbone. In addition, palm oil is well endowed with a bouquet of phytonutrients beneficial to health, such as tocotrienols, carotenoids, and phytosterols. This review will provide an overview of studies that have established palm oil as a balanced and nutritious oil.

  5. Research advancements in palm oil nutrition*

    PubMed Central

    May, Choo Yuen; Nesaretnam, Kalanithi

    2014-01-01

    Palm oil is the major oil produced, with annual world production in excess of 50 million tonnes. About 85% of global palm oil produced is used in food applications. Over the past three decades, research on nutritional benefits of palm oil have demonstrated the nutritional adequacy of palm oil and its products, and have resulted in transitions in the understanding these attributes. Numerous studies have demonstrated that palm oil was similar to unsaturated oils with regards to effects on blood lipids. Palm oil provides a healthy alternative to trans-fatty acid containing hydrogenated fats that have been demonstrated to have serious deleterious effects on health. The similar effects of palm oil on blood lipids, comparable to other vegetable oils could very well be due to the structure of the major triglycerides in palm oil, which has an unsaturated fatty acid in the stereospecific numbers (sn)-2 position of the glycerol backbone. In addition, palm oil is well endowed with a bouquet of phytonutrients beneficial to health, such as tocotrienols, carotenoids, and phytosterols. This review will provide an overview of studies that have established palm oil as a balanced and nutritious oil. PMID:25821404

  6. 76 FR 13666 - General Motors Corporation; Powertrain Flint North; Including On-Site Leased Workers From Allegis...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-14

    ... Employment and Training Administration General Motors Corporation; Powertrain Flint North; Including On- Site Leased Workers From Allegis Group Services, Securitas, Knight Management and URS Corporation, Flint, MI... to workers of General Motors Corporation, Powertrain Flint North, including on-site leased...

  7. 76 FR 46852 - Workers From Kelly Services, Working On-Site at Delphi Automotive Systems, LLC, Powertrain...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-03

    ... Systems, LLC, Powertrain Division, El Paso, TX; Amended Certification Regarding Eligibility To Apply for... workers from Kelly Services working on-site at Delphi Automotive Systems, LLC, El Paso, Texas. The workers... Automotive Systems, LLC, Powertrain Division, El Paso, Texas. Accordingly, the Department is amended...

  8. Linguistic Alternatives to Quantitative Research Strategies. Part One: How Linguistic Mechanisms Advance Research Outcomes

    ERIC Educational Resources Information Center

    Yeager, Joseph; Sommer, Linda

    2007-01-01

    Combining psycholinguistic technologies and systems analysis created advances in motivational profiling and numerous new behavioral engineering applications. These advances leapfrog many mainstream statistical research methods, producing superior research results via cause-effect language mechanisms. Entire industries explore motives ranging from…

  9. Magnetized Target Fusion in Advanced Propulsion Research

    NASA Technical Reports Server (NTRS)

    Cylar, Rashad

    2003-01-01

    The Magnetized Target Fusion (MTF) Propulsion lab at NASA Marshall Space Flight Center in Huntsville, Alabama has a program in place that has adopted to attempt to create a faster, lower cost and more reliable deep space transportation system. In this deep space travel the physics and development of high velocity plasma jets must be understood. The MTF Propulsion lab is also in attempt to open up the solar system for human exploration and commercial use. Fusion, as compared to fission, is just the opposite. Fusion involves the light atomic nuclei combination to produce denser nuclei. In the process, the energy is created by destroying the mass according to the distinguished equation: E = mc2 . Fusion energy development is being pursued worldwide as a very sustainable form of energy that is environmentally friendly. For the purposes of space exploration fusion reactions considered include the isotopes of hydrogen-deuterium (D2) and tritium (T3). Nuclei have an electrostatic repulsion between them and in order for the nuclei to fuse this repulsion must be overcome. One technique to bypass repulsion is to heat the nuclei to very high temperatures. The temperatures vary according to the type of reactions. For D-D reactions, one billion degrees Celsius is required, and for D-T reactions, one hundred million degrees is sufficient. There has to be energy input for useful output to be obtained form the fusion To make fusion propulsion practical, the mass, the volume, and the cost of the equipment to produce the reactions (generally called the reactor) need to be reduced by an order of magnitude or two from the state-of-the-art fusion machines. Innovations in fusion schemes are therefore required, especially for obtaining thrust for propulsive applications. Magnetized target fusion (MTF) is one of the innovative fusion concepts that have emerged over the last several years. MSFC is working with Los Alamos National Laboratory and other research groups in studying the

  10. Performance comparison of two fuel cell hybrid buses with different powertrain and energy management strategies

    NASA Astrophysics Data System (ADS)

    Ouyang, Minggao; Xu, Liangfei; Li, Jianqiu; Lu, Languang; Gao, Dawei; Xie, Qicheng

    In order to assess the influences of different powertrain structures and energy management strategies on the performance of hybrid fuel cell buses (FCB), two buses (FCB A and FCB B) were constructed with a "energy hybrid structure" and "power hybrid structure", respectively. Different energy management strategies were investigated based on analysis of the two systems. And the two buses were compared with each other in a bus cycle and constant speed testing. The Polymer Electrolyte Membrane Fuel Cell (PEMFC) in FCB A showed an advantage in fuel economy for it worked usually in the high efficient range of the PEMFC engine. The hydrogen consumption rate in the cycle testing was 7.9 kg/100 km and 9.8 kg/100 km for FCB A and FCB B, and in the 40 kmph constant speed testing it was 3.3 kg/100 km and 4.0 kg/100 km, respectively. The fuel economy could be improved when the hydrogen and air supply subsystems are optimized and controlled with an advanced algorithm. It could also benefit from a braking energy regeneration system. Compared with FCB A, the PEMFC in FCB B worked under unfavorable operation conditions because its working range was comparatively wide, and the power changing rate was relatively large from a statistical point of view, which resulted in performance recession of the PEMFC in FCB B. After a mileage of 7000 km, the output power of the PEMFC in FCB B was reduced by 10%, compared with 2.4% in FCB A. An advanced energy management strategy is necessary to split the power between the PEMFC and a battery suitable for long durability of a PEMFC.

  11. Advancing social research relationships in postnatal support settings.

    PubMed

    Tighe, Maria; Peters, Jane; Skirton, Heather

    2013-05-01

    Global trends in public health nursing (PHN) suggest the value of community-based social research. However, it is not always clear how social research relationships may be of benefit to PHN or how such skills can best be learned and applied. To advance this understanding, we present a qualitative analysis of the development of social research relationships in PHN. Using a background literature review as a foundation, our qualitative mixed method strategy involved a comparative case-study analysis based on the authors' participant observation in two distinct postnatal group settings. Our findings suggest that participant observation facilitates the advancement of social research relationships through practitioner-research management of role conflict. Reflexivity and reciprocity is an emergent relational process, which relies upon a de-professionalization of the traditional PHN role. Conversely, social research relationships help build PHN capacity for family health needs assessment. Thus, we contend that the application of participant observation enables the development of social research relationships, which advance the practice of PHN in postnatal support settings.

  12. Advanced technology airfoil research, volume 1, part 2

    NASA Technical Reports Server (NTRS)

    1978-01-01

    This compilation contains papers presented at the NASA Conference on Advanced Technology Airfoil Research held at Langley Research Center on March 7-9, 1978, which have unlimited distribution. This conference provided a comprehensive review of all NASA airfoil research, conducted in-house and under grant and contract. A broad spectrum of airfoil research outside of NASA was also reviewed. The major thrust of the technical sessions were in three areas: development of computational aerodynamic codes for airfoil analysis and design, development of experimental facilities and test techniques, and all types of airfoil applications.

  13. Construction of databases: advances and significance in clinical research.

    PubMed

    Long, Erping; Huang, Bingjie; Wang, Liming; Lin, Xiaoyu; Lin, Haotian

    2015-12-01

    Widely used in clinical research, the database is a new type of data management automation technology and the most efficient tool for data management. In this article, we first explain some basic concepts, such as the definition, classification, and establishment of databases. Afterward, the workflow for establishing databases, inputting data, verifying data, and managing databases is presented. Meanwhile, by discussing the application of databases in clinical research, we illuminate the important role of databases in clinical research practice. Lastly, we introduce the reanalysis of randomized controlled trials (RCTs) and cloud computing techniques, showing the most recent advancements of databases in clinical research.

  14. Advancing a program of research within a nursing faculty role.

    PubMed

    Nolan, Marie T; Wenzel, Jennifer; Han, Hae-Ra; Allen, Jerilyn K; Paez, Kathryn A; Mock, Victoria

    2008-01-01

    Doctoral students and new faculty members often seek advice from more senior faculty on how to advance their program of research. Students may ask whether they should choose the manuscript option for their dissertation or whether they should seek a postdoctoral fellowship. New faculty members wonder whether they should pursue a career development award and whether they need a mentor as they strive to advance their research while carrying out teaching, service, and practice responsibilities. In this article, we describe literature on the impact of selected aspects of pre- and postdoctoral training and faculty strategies on scholarly productivity in the faculty role. We also combine our experiences at a school of nursing within a research-intensive university to suggest strategies for success. Noting the scarcity of research that evaluates the effect of these strategies, we are actively engaged in collecting data on their relationship to the scholarly productivity of students and faculty members within our own institution.

  15. The Evaluation of the Impact of New Technologies for Different Powertrain Medium-Duty Trucks on Fuel Consumption

    SciTech Connect

    Wang, Lijuan; Duran, Adam; Kelly, Kenneth; Konan, Arnaud; Lammert, Michael; Prohaska, Robert

    2016-09-27

    In this paper, researchers at the National Renewable Energy Laboratory present the results of simulation studies to evaluate potential fuel savings as a result of improvements to vehicle rolling resistance, coefficient of drag, and vehicle weight as well as hybridization for four powertrains for medium-duty parcel delivery vehicles. The vehicles will be modeled and simulated over 1,290 real-world driving trips to determine the fuel savings potential based on improvements to each technology and to identify best use cases for each platform. The results of impacts of new technologies on fuel saving will be presented, and the most favorable driving routes on which to adopt them will be explored.

  16. [Research advance in rare and endemic plant Tetraena mongolica Maxim].

    PubMed

    Zhen, Jiang-Hong; Liu, Guo-Hou

    2008-02-01

    In this paper, the research advance in rare and endemic plant Tetraena mongolica Maxim. was summarized from the aspects of morphology, anatomy, palynology, cytology, seed-coat micro-morphology, embryology, physiology, biology, ecology, genetic diversity, chemical constituents, endangered causes, and conservation approaches, and the further research directions were prospected. It was considered that population viability, idioplasm conservation and artificial renewal, molecular biology of ecological adaptability, and assessment of habitat suitability should be the main aspects for the future study of T. mongolica.

  17. INL Advanced Radiotherapy Research Program Annual Report 2004

    SciTech Connect

    James Venhuizen

    2005-06-01

    This report summarizes the activities and major accomplishments for the Idaho National Laboratory Advanced Radiotherapy Research Program for calendar year 2004. Topics covered include boron analysis in biological samples, computational dosimetry and treatment planning software development, medical neutron source development and characterization, and collaborative dosimetry studies at the RA-1 facility in Buenos Aires, Argentina.

  18. Center for Advanced Power and Energy Research (CAPEC)

    DTIC Science & Technology

    2015-01-01

    University structured through a cooperative research agreement. Our organizational focuses include: 1. Modeling of plasma physics 2. Modeling fuel cells 3...Testing new innovation and ideas for advanced fuel cells 4. Development of energy related issue for micro air vehicles (MAVs). 15. SUBJECT TERMS plasma ...1 2 Plasma Modeling

  19. [Advances in research of dihydroartemisinin against parasitic diseases].

    PubMed

    Li, Hong-Jun; Wang, Wei; Liang, You-Sheng

    2011-08-01

    Dihydroartemisinin, the main metabolite of artemisinin and two artemisinin derivatives, artemether and artesunate, is a broad-spectrum anti-parasitic drug. The present paper systematically reviews the advances in research of dihydroartemisinin against Plasmodium, Schistosoma, Pneumocystis, Toxoplasma, Trichomonas vaginalis, Leishmania, Giardia lamblia.

  20. INEEL Advanced Radiotherapy Research Program Annual Report for 2002

    SciTech Connect

    J. R. Venhuizen

    2003-05-01

    This report summarizes the activities and major accomplishments for the Idaho National Engineering and Environmental Laboratory (INEEL) Advanced Radiotherapy Research Program for calendar year 2002. Topics covered include computational dosimetry and treatment planning software development, medical neutron source development and characterization, and boron analytical chemistry.

  1. INEEL Advanced Radiotherapy Research Program Annual Report 2002

    SciTech Connect

    Venhuizen, J.R.

    2003-05-23

    This report summarizes the activities and major accomplishments for the Idaho National Engineering and Environmental Laboratory (INEEL) Advanced Radiotherapy Research Program for calendar year 2002. Topics covered include computational dosimetry and treatment planning software development, medical neutron source development and characterization, and boron analytical chemistry.

  2. Defining Neighborhood Boundaries for Social Measurement: Advancing Social Work Research

    ERIC Educational Resources Information Center

    Foster, Kirk A.; Hipp, J. Aaron

    2011-01-01

    Much of the current neighborhood-based research uses variables aggregated on administrative boundaries such as zip codes, census tracts, and block groups. However, other methods using current technological advances in geographic sciences may broaden our ability to explore the spatial concentration of neighborhood factors affecting individuals and…

  3. Human Intelligence: An Introduction to Advances in Theory and Research.

    ERIC Educational Resources Information Center

    Lohman, David F.

    1989-01-01

    Recent advances in three research traditions are summarized: trait theories of intelligence, information-processing theories of intelligence, and general theories of thinking. Work on fluid and crystallized abilities by J. Horn and R. Snow, mental speed, spatial visualization, cognitive psychology, artificial intelligence, and the construct of…

  4. Advanced Pediatric Brain Imaging Research and Training Program

    DTIC Science & Technology

    2014-10-01

    AD_________________ Award Number: W81XWH-11-2-0198 TITLE: Advanced Pediatric Brain Imaging... Brain Imaging Research Program 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-11-2-0198 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Catherine...AVAILABILITY STATEMENT Approved for Public Release; Distribution Unlimited 13. SUPPLEMENTARY NOTES Brain injury is a leading cause of

  5. Advanced materials research for long-haul aircraft turbine engines

    NASA Technical Reports Server (NTRS)

    Signorelli, R. A.; Blankenship, C. P.

    1978-01-01

    The status of research efforts to apply low to intermediate temperature composite materials and advanced high temperature materials to engine components is reviewed. Emerging materials technologies and their potential benefits to aircraft gas turbines were emphasized. The problems were identified, and the general state of the technology for near term use was assessed.

  6. Summary of Advances in Autism Spectrum Disorder Research, 2009

    ERIC Educational Resources Information Center

    Interagency Autism Coordinating Committee, 2009

    2009-01-01

    Each year the members of the Interagency Autism Coordinating Committee identify recent research findings that made the most impact on the field. For the 2009 Summary of Advances, the IACC selected and summarized 20 studies that gave significant insight into the prevalence of autism spectrum disorder (ASD), the biology of the disorder, potential…

  7. Advanced Composite Structures At NASA Langley Research Center

    NASA Technical Reports Server (NTRS)

    Eldred, Lloyd B.

    2015-01-01

    Dr. Eldred's presentation will discuss several NASA efforts to improve and expand the use of composite structures within aerospace vehicles. Topics will include an overview of NASA's Advanced Composites Project (ACP), Space Launch System (SLS) applications, and Langley's ISAAC robotic composites research tool.

  8. Activities of the Research Institute for Advanced Computer Science

    NASA Technical Reports Server (NTRS)

    Oliger, Joseph

    1994-01-01

    The Research Institute for Advanced Computer Science (RIACS) was established by the Universities Space Research Association (USRA) at the NASA Ames Research Center (ARC) on June 6, 1983. RIACS is privately operated by USRA, a consortium of universities with research programs in the aerospace sciences, under contract with NASA. The primary mission of RIACS is to provide research and expertise in computer science and scientific computing to support the scientific missions of NASA ARC. The research carried out at RIACS must change its emphasis from year to year in response to NASA ARC's changing needs and technological opportunities. Research at RIACS is currently being done in the following areas: (1) parallel computing; (2) advanced methods for scientific computing; (3) high performance networks; and (4) learning systems. RIACS technical reports are usually preprints of manuscripts that have been submitted to research journals or conference proceedings. A list of these reports for the period January 1, 1994 through December 31, 1994 is in the Reports and Abstracts section of this report.

  9. Recent Advances in Cigarette Ignition Propensity Research and Development

    PubMed Central

    O’Connor, Richard J.; Spalletta, Ron; Connolly, Gregory N.

    2009-01-01

    Major U.S. cigarette companies for decades conducted research and development regarding cigarette ignition propensity which has continued beyond fire safety standards for cigarettes that have recently been legislated. This paper describes recent scientific advances and technological development based on a comprehensive review of the physical, chemical, and engineering sciences, public health, and trade literature, U.S. and international patents, and research in the tobacco industry document libraries. Advancements since the first implementation of standards have made been in: a) understanding the key parameters involved in cigarette smoldering combustion and ignition of substrates; b) developing new cigarette and paper wrapper designs to reduce ignition propensity, including banded and non-banded cigarette paper approaches, c) assessing toxicology, and d) measuring performance. While the implications of manufacturers’ non-safety related aims are of concern, this research indicates possible alternative designs should experience with fire loss and existing technologies on the market suggest need for improvement. PMID:20495669

  10. Advanced Life Support Research and Technology Development Metric

    NASA Technical Reports Server (NTRS)

    Hanford, A. J.

    2004-01-01

    The Metric is one of several measures employed by the NASA to assess the Agency s progress as mandated by the United States Congress and the Office of Management and Budget. Because any measure must have a reference point, whether explicitly defined or implied, the Metric is a comparison between a selected ALS Project life support system and an equivalently detailed life support system using technology from the Environmental Control and Life Support System (ECLSS) for the International Space Station (ISS). This document provides the official calculation of the Advanced Life Support (ALS) Research and Technology Development Metric (the Metric) for Fiscal Year 2004. The values are primarily based on Systems Integration, Modeling, and Analysis (SIMA) Element approved software tools or reviewed and approved reference documents. For Fiscal Year 2004, the Advanced Life Support Research and Technology Development Metric value is 2.03 for an Orbiting Research Facility and 1.62 for an Independent Exploration Mission.

  11. Recent Advances in Cigarette Ignition Propensity Research and Development.

    PubMed

    Alpert, Hillel R; O'Connor, Richard J; Spalletta, Ron; Connolly, Gregory N

    2010-04-01

    Major U.S. cigarette companies for decades conducted research and development regarding cigarette ignition propensity which has continued beyond fire safety standards for cigarettes that have recently been legislated. This paper describes recent scientific advances and technological development based on a comprehensive review of the physical, chemical, and engineering sciences, public health, and trade literature, U.S. and international patents, and research in the tobacco industry document libraries.Advancements since the first implementation of standards have made been in: a) understanding the key parameters involved in cigarette smoldering combustion and ignition of substrates; b) developing new cigarette and paper wrapper designs to reduce ignition propensity, including banded and non-banded cigarette paper approaches, c) assessing toxicology, and d) measuring performance. While the implications of manufacturers' non-safety related aims are of concern, this research indicates possible alternative designs should experience with fire loss and existing technologies on the market suggest need for improvement.

  12. First Aviation System Technology Advanced Research (AvSTAR) Workshop

    NASA Technical Reports Server (NTRS)

    Denery, Dallas G. (Editor); Weathers, Del W. (Editor); Rosen, Robert (Technical Monitor); Edwards, Tom (Technical Monitor)

    2001-01-01

    This Conference Proceedings documents the results of a two-day NASA/FAA/Industry workshop that was held at the NASA Ames Research Center, located at Moffett Field, CA, on September 21-22, 2000. The purpose of the workshop was to bring together a representative cross section of leaders in air traffic management, from industry. FAA, and academia, to assist in defining the requirements for a new research effort, referred to as AvSTAR Aviation Systems Technology Advanced Research). The Conference Proceedings includes the individual presentation, and summarizes the workshop discussions and recommendations.

  13. Transnationalism: A Framework for Advancing Nursing Research with Contemporary Immigrants

    PubMed Central

    Rosemberg, Marie-Anne S.; Boutain, Doris M.; Mohammed, Selina A.

    2016-01-01

    This article advances nursing research by presenting transnationalism as a framework for inquiry with contemporary immigrants. Transnationalism occurs when immigrants maintain relationships that transcend the geographical borders of their origin and host countries. Immigrants use those relationships to experience health differently within concurrent socioeconomic, political and cultural contexts than national situated populations. Nurse researchers are called upon to consider these trans-border relationships when exploring the health of contemporary immigrants. Such consideration is needed to develop relevant research designs, methods, analysis, and dissemination strategies. PMID:26836998

  14. Advanced Combustion and Emission Control Technical Team Roadmap

    SciTech Connect

    2013-06-01

    The Advanced Combustion and Emission Control (ACEC) Technical Team is focused on removing technical barriers to the commercialization of advanced, high-efficiency, emission-compliant internal combustion (IC) engines for light-duty vehicle powertrains (i.e., passenger car, minivan, SUV, and pickup trucks).

  15. Advances in Statistical Methods for Substance Abuse Prevention Research

    PubMed Central

    MacKinnon, David P.; Lockwood, Chondra M.

    2010-01-01

    The paper describes advances in statistical methods for prevention research with a particular focus on substance abuse prevention. Standard analysis methods are extended to the typical research designs and characteristics of the data collected in prevention research. Prevention research often includes longitudinal measurement, clustering of data in units such as schools or clinics, missing data, and categorical as well as continuous outcome variables. Statistical methods to handle these features of prevention data are outlined. Developments in mediation, moderation, and implementation analysis allow for the extraction of more detailed information from a prevention study. Advancements in the interpretation of prevention research results include more widespread calculation of effect size and statistical power, the use of confidence intervals as well as hypothesis testing, detailed causal analysis of research findings, and meta-analysis. The increased availability of statistical software has contributed greatly to the use of new methods in prevention research. It is likely that the Internet will continue to stimulate the development and application of new methods. PMID:12940467

  16. Advancing the research agenda for diagnostic error reduction.

    PubMed

    Zwaan, Laura; Schiff, Gordon D; Singh, Hardeep

    2013-10-01

    Diagnostic errors remain an underemphasised and understudied area of patient safety research. We briefly summarise the methods that have been used to conduct research on epidemiology, contributing factors and interventions related to diagnostic error and outline directions for future research. Research methods that have studied epidemiology of diagnostic error provide some estimate on diagnostic error rates. However, there appears to be a large variability in the reported rates due to the heterogeneity of definitions and study methods used. Thus, future methods should focus on obtaining more precise estimates in different settings of care. This would lay the foundation for measuring error rates over time to evaluate improvements. Research methods have studied contributing factors for diagnostic error in both naturalistic and experimental settings. Both approaches have revealed important and complementary information. Newer conceptual models from outside healthcare are needed to advance the depth and rigour of analysis of systems and cognitive insights of causes of error. While the literature has suggested many potentially fruitful interventions for reducing diagnostic errors, most have not been systematically evaluated and/or widely implemented in practice. Research is needed to study promising intervention areas such as enhanced patient involvement in diagnosis, improving diagnosis through the use of electronic tools and identification and reduction of specific diagnostic process 'pitfalls' (eg, failure to conduct appropriate diagnostic evaluation of a breast lump after a 'normal' mammogram). The last decade of research on diagnostic error has made promising steps and laid a foundation for more rigorous methods to advance the field.

  17. [Activities of Research Institute for Advanced Computer Science

    NASA Technical Reports Server (NTRS)

    Gross, Anthony R. (Technical Monitor); Leiner, Barry M.

    2001-01-01

    The Research Institute for Advanced Computer Science (RIACS) carries out basic research and technology development in computer science, in support of the National Aeronautics and Space Administrations missions. RIACS is located at the NASA Ames Research Center, Moffett Field, California. RIACS research focuses on the three cornerstones of IT research necessary to meet the future challenges of NASA missions: 1. Automated Reasoning for Autonomous Systems Techniques are being developed enabling spacecraft that will be self-guiding and self-correcting to the extent that they will require little or no human intervention. Such craft will be equipped to independently solve problems as they arise, and fulfill their missions with minimum direction from Earth. 2. Human-Centered Computing Many NASA missions require synergy between humans and computers, with sophisticated computational aids amplifying human cognitive and perceptual abilities. 3. High Performance Computing and Networking Advances in the performance of computing and networking continue to have major impact on a variety of NASA endeavors, ranging from modeling and simulation to analysis of large scientific datasets to collaborative engineering, planning and execution. In addition, RIACS collaborates with NASA scientists to apply IT research to a variety of NASA application domains. RIACS also engages in other activities, such as workshops, seminars, visiting scientist programs and student summer programs, designed to encourage and facilitate collaboration between the university and NASA IT research communities.

  18. Rhetorical Strategies in Engineering Research Articles and Research Theses: Advanced Academic Literacy and Relations of Power

    ERIC Educational Resources Information Center

    Koutsantoni, Dimitra

    2006-01-01

    Research articles and research theses constitute two key genres used by scientific communities for the dissemination and ratification of knowledge. Both genres are produced at advanced stages of individuals' enculturation in disciplinary communities present original research aim to persuade the academic community to accept new knowledge claims,…

  19. Developing Research Infrastructure: The Institute for the Advancement of Social Work Research

    ERIC Educational Resources Information Center

    Zlotnik, Joan Levy; Solt, Barbara E.

    2008-01-01

    This article reviews the 15 years of research development efforts of the Institute for the Advancement of Social Work Research (IASWR); delineates IASWR's roles in relation to the social work practice, education, and research communities; presents the transdisciplinary and transorganizational partnerships in which IASWR engages to influence…

  20. Advanced Turbine Technology Applications Project (ATTAP)

    NASA Technical Reports Server (NTRS)

    1989-01-01

    ATTAP activities during the past year were highlighted by an extensive materials assessment, execution of a reference powertrain design, test-bed engine design and development, ceramic component design, materials and component characterization, ceramic component process development and fabrication, component rig design and fabrication, test-bed engine fabrication, and hot gasifier rig and engine testing. Materials assessment activities entailed engine environment evaluation of domestically supplied radial gasifier turbine rotors that were available at the conclusion of the Advanced Gas Turbine (AGT) Technology Development Project as well as an extensive survey of both domestic and foreign ceramic suppliers and Government laboratories performing ceramic materials research applicable to advanced heat engines. A reference powertrain design was executed to reflect the selection of the AGT-5 as the ceramic component test-bed engine for the ATTAP. Test-bed engine development activity focused on upgrading the AGT-5 from a 1038 C (1900 F) metal engine to a durable 1371 C (2500 F) structural ceramic component test-bed engine. Ceramic component design activities included the combustor, gasifier turbine static structure, and gasifier turbine rotor. The materials and component characterization efforts have included the testing and evaluation of several candidate ceramic materials and components being developed for use in the ATTAP. Ceramic component process development and fabrication activities were initiated for the gasifier turbine rotor, gasifier turbine vanes, gasifier turbine scroll, extruded regenerator disks, and thermal insulation. Component rig development activities included combustor, hot gasifier, and regenerator rigs. Test-bed engine fabrication activities consisted of the fabrication of an all-new AGT-5 durability test-bed engine and support of all engine test activities through instrumentation/build/repair. Hot gasifier rig and test-bed engine testing

  1. Magnetohydrodynamics Accelerator Research into Advanced Hypersonics (MARIAH). Part 2

    NASA Technical Reports Server (NTRS)

    Baughman, Jack A.; Micheletti, David A.; Nelson, Gordon L.; Simmons, Gloyd A.

    1997-01-01

    This report documents the activities, results, conclusions and recommendations of the Magnetohydrodynamics Accelerator Research Into Advanced Hypersonics (MARIAH) Project in which the use of magnetohydrodynamics (MHD) technology is investigated for its applicability to augment hypersonic wind tunnels. The long range objective of this investigation is to advance the development of ground test facilities to support the development of hypervelocity flight vehicles. The MHD accelerator adds kinetic energy directly to the wind tunnel working fluid, thereby increasing its Mach number to hypervelocity levels. Several techniques for MHD augmentation, as well as other physical characteristics of the process are studied to enhance the overall performance of hypersonic wind tunnel design. Specific recommendations are presented to improve the effectiveness of ground test facilities. The work contained herein builds on nearly four decades of research and experimentation by the aeronautics ground test and evaluation community, both foreign and domestic.

  2. Magnetohydrodynamics Accelerator Research Into Advanced Hypersonics (MARIAH). Part 1

    NASA Technical Reports Server (NTRS)

    Micheletti, David A.; Baughman, Jack A.; Nelson, Gordon L.; Simmons, Gloyd A.

    1997-01-01

    This report documents the activities, results, conclusions and recommendations of the Magnetohydrodynamics Accelerator Research Into Advanced Hypersonics (MARIAH) Project in which the use of magnetohydrodynamics (MHD) technology is investigated for its applicability to augment hypersonic wind tunnels. The long range objective of this investigation is to advance the development of ground test facilities to support the development of hypervelocity flight vehicles. The MHD accelerator adds kinetic energy directly to the wind tunnel working fluid, thereby increasing its Mach number to hypervelocity levels. Several techniques for MHD augmentation, as well as other physical characteristics of the process are studied to enhance the overall performance of hypersonic wind tunnel design. Specific recommendations are presented to improve the effectiveness of ground test facilities. The work contained herein builds on nearly four decades of research and experimentation by the aeronautics ground test and evaluation community, both foreign and domestic.

  3. [Economic perspectives of the research on advanced therapies].

    PubMed

    Pamo Larrauri, Jose María

    2014-11-03

    Since a new advanced therapy medicinal product is discovered until finally allowed its sale in the domestic market, it has to overcome a series of stages. Biomedical research is the first phase, currently its situation is encouraging to the increase in the number of clinical trials in Spain and in the rest of the world, despite the economic situation and the various difficulties that have faced the pharmaceutical laboratories. The next phase consists in obtaining the authorization of marketing of the European Medicines Agency. After authorization, will attempt to set a fair and moderate price for inclusion in the list of health provision of Social Security. A price for a drug that provides added value to health and society, a price that is generated profits for the pharmaceutical companies that hope to make up for the years of work and investment. Commitment to advanced therapy must be clear and forceful, to fund ongoing research projects and encouraging their creation with economic aid.

  4. Recent advances in research on Crimean-Congo hemorrhagic fever.

    PubMed

    Papa, Anna; Mirazimi, Ali; Köksal, Iftihar; Estrada-Pena, Augustin; Feldmann, Heinz

    2015-03-01

    Crimean-Congo hemorrhagic fever (CCHF) is an expanding tick-borne hemorrhagic disease with increasing human and animal health impact. Immense knowledge was gained over the past 10 years mainly due to advances in molecular biology, but also driven by an increased global interest in CCHFV as an emerging/re-emerging zoonotic pathogen. In the present article, we discuss the advances in research with focus on CCHF ecology, epidemiology, pathogenesis, diagnostics, prophylaxis and treatment. Despite tremendous achievements, future activities have to concentrate on the development of vaccines and antivirals/therapeutics to combat CCHF. Vector studies need to continue for better public and animal health preparedness and response. We conclude with a roadmap for future research priorities.

  5. Advances and future directions of research on spectral methods

    NASA Technical Reports Server (NTRS)

    Patera, A. T.

    1986-01-01

    Recent advances in spectral methods are briefly reviewed and characterized with respect to their convergence and computational complexity. Classical finite element and spectral approaches are then compared, and spectral element (or p-type finite element) approximations are introduced. The method is applied to the full Navier-Stokes equations, and examples are given of the application of the technique to several transitional flows. Future directions of research in the field are outlined.

  6. Collaboration in Research and Engineering for Advanced Technology.

    SciTech Connect

    Vrieling, P. Douglas

    2016-01-01

    SNL/CA proposes the Collaboration in Research and Engineering for Advanced Technology and Education (CREATE) facility to support customer-driven national security mission requirements while demonstrating a fiscally responsible approach to cost-control. SNL/CA realizes that due to the current backlog of capital projects in NNSA that following the normal Line Item process to procure capital funding is unlikely and therefore SNL/CA will be looking at all options including Alternative Financing.

  7. [Advancing public mental health research in Latin America].

    PubMed

    Susser, Ezra

    2015-01-01

    This special issue on Mental Health of the Journal of the School of Medicine, represents a significant contribution to the advance of public mental health research and training in Latin America. The editors (as well as the authors) deserve much credit for having conceived and implemented the joint publication of these papers. In this brief introduction, I draw attention to four ways in which their effort is likely to accelerate progress in this field.

  8. Fossil Energy Advanced Research and Technology Development Materials Program

    SciTech Connect

    Cole, N.C.; Judkins, R.R.

    1992-12-01

    Objective of this materials program is to conduct R and D on materials for fossil energy applications with focus on longer-term and generic needs of the various fossil fuel technologies. The projects are organized according to materials research areas: (1) ceramics, (2) new alloys: iron aluminides, advanced austenitics and chromium niobium alloys, and (3) technology development and transfer. Separate abstracts have been prepared.

  9. Advanced High-Level Waste Glass Research and Development Plan

    SciTech Connect

    Peeler, David K.; Vienna, John D.; Schweiger, Michael J.; Fox, Kevin M.

    2015-07-01

    The U.S. Department of Energy Office of River Protection (ORP) has implemented an integrated program to increase the loading of Hanford tank wastes in glass while meeting melter lifetime expectancies and process, regulatory, and product quality requirements. The integrated ORP program is focused on providing a technical, science-based foundation from which key decisions can be made regarding the successful operation of the Hanford Tank Waste Treatment and Immobilization Plant (WTP) facilities. The fundamental data stemming from this program will support development of advanced glass formulations, key process control models, and tactical processing strategies to ensure safe and successful operations for both the low-activity waste (LAW) and high-level waste (HLW) vitrification facilities with an appreciation toward reducing overall mission life. The purpose of this advanced HLW glass research and development plan is to identify the near-, mid-, and longer-term research and development activities required to develop and validate advanced HLW glasses and their associated models to support facility operations at WTP, including both direct feed and full pretreatment flowsheets. This plan also integrates technical support of facility operations and waste qualification activities to show the interdependence of these activities with the advanced waste glass (AWG) program to support the full WTP mission. Figure ES-1 shows these key ORP programmatic activities and their interfaces with both WTP facility operations and qualification needs. The plan is a living document that will be updated to reflect key advancements and mission strategy changes. The research outlined here is motivated by the potential for substantial economic benefits (e.g., significant increases in waste throughput and reductions in glass volumes) that will be realized when advancements in glass formulation continue and models supporting facility operations are implemented. Developing and applying advanced

  10. Drive Cycle Powertrain Efficiencies and Trends Derived from EPA Vehicle Dynamometer Results

    SciTech Connect

    Thomas, John

    2014-10-13

    Vehicle manufacturers among others are putting great emphasis on improving fuel economy (FE) of light-duty vehicles in the U.S. market, with significant FE gains being realized in recent years. The U.S. Environmental Protection Agency (EPA) data indicates that the aggregate FE of vehicles produced for the U.S. market has improved by over 20% from model year (MY) 2005 to 2013. This steep climb in FE includes changes in vehicle choice, improvements in engine and transmission technology, and reducing aerodynamic drag, rolling resistance, and parasitic losses. The powertrain related improvements focus on optimizing in-use efficiency of the transmission and engine as a system, and may make use of what is termed downsizing and/or downspeeding. This study explores quantifying recent improvements in powertrain efficiency, viewed separately from other vehicle alterations and attributes (noting that most vehicle changes are not completely independent). A methodology is outlined to estimate powertrain efficiency for the U.S city and highway cycle tests using data from the EPA vehicle database. Comparisons of common conventional gasoline powertrains for similar MY 2005 and 2013 vehicles are presented, along with results for late-model hybrid electric vehicles, the Nissan Leaf, Chevy Volt and other selected vehicles.

  11. Drive Cycle Powertrain Efficiencies and Trends Derived from EPA Vehicle Dynamometer Results

    DOE PAGES

    Thomas, John

    2014-10-13

    Vehicle manufacturers among others are putting great emphasis on improving fuel economy (FE) of light-duty vehicles in the U.S. market, with significant FE gains being realized in recent years. The U.S. Environmental Protection Agency (EPA) data indicates that the aggregate FE of vehicles produced for the U.S. market has improved by over 20% from model year (MY) 2005 to 2013. This steep climb in FE includes changes in vehicle choice, improvements in engine and transmission technology, and reducing aerodynamic drag, rolling resistance, and parasitic losses. The powertrain related improvements focus on optimizing in-use efficiency of the transmission and engine asmore » a system, and may make use of what is termed downsizing and/or downspeeding. This study explores quantifying recent improvements in powertrain efficiency, viewed separately from other vehicle alterations and attributes (noting that most vehicle changes are not completely independent). A methodology is outlined to estimate powertrain efficiency for the U.S city and highway cycle tests using data from the EPA vehicle database. Comparisons of common conventional gasoline powertrains for similar MY 2005 and 2013 vehicles are presented, along with results for late-model hybrid electric vehicles, the Nissan Leaf, Chevy Volt and other selected vehicles.« less

  12. Investigation of energy-efficient MRF-based clutches for hybrid powertrains

    NASA Astrophysics Data System (ADS)

    Hegger, Christian; Maas, Jürgen

    2016-04-01

    The requirements for transmission and coupling elements in hybrid powertrains are rising continuously. On this occasion a novel clutch-design is investigated and validated in this contribution. The transmission of power is based on magnetorheological fluids (MRF) including a fluid movement control for enabling a drag torque-free operation for an increased energy efficient operation. Drag losses in powertrains are a serious deficiency for an energy-efficient application. MRFs are highly qualified for the utilization in powertrains considering their particular characteristics of changing their apparent viscosity significantly under influence of a magnetic field by fast switching times and a smooth torque control. The proposed MRF-clutch with three different variations of the fluid movement control is designed based on a numerical model and validated by experimental measurements with a realized prototype. The main aspects during the investigation are focused on the coupling functions under the influence of high rotational speeds up to 6000 min-1 and also the safety behavior of the different variations by the fluid control in case of a system failure. The theoretical and experimental investigation demonstrates the suitability for an integration of clutches based on MRF in electrical or hybrid powertrains as an alternative to conventional coupling elements.

  13. Evaluation Methodology for Surface Engineering Techniques to Improve Powertrain Efficiency in Military Vehicles

    DTIC Science & Technology

    2012-06-01

    The primary goal of the initial phase of evaluation is to experimentally measure the efficiency of gears and other tribological components with and...benefits of surface treatment to reciprocating mechanical components. 15. SUBJECT TERMS Surface engineering, gear efficiency, powertrain, tribology ...considered as a tribological system (gear surfaces, base oil, additives, surface chemistry, etc.) such that a change in one component may require

  14. [Research advances in association between pediatric obesity and bronchial asthma].

    PubMed

    Zhu, Lian; Xu, Zhi-Liang; Cheng, Yan-Yang

    2016-07-01

    This review article introduces the research advances in the pathophysiological mechanism of obesity in inducing pediatric bronchial asthma, including the role of leptin in obesity and asthma, the association of plasminogen activator inhibitor-1 with obesity and asthma, the association of adiponectin and interleukins with obesity and asthma, and the influence of neurotransmitter on asthma. In particular, this article introduces the latest research on the inhibition of allergic asthma through targeting at the nociceptor of dorsal root ganglion and blocking the signaling pathway of the nociceptor.

  15. Advanced accelerator and mm-wave structure research at LANL

    SciTech Connect

    Simakov, Evgenya Ivanovna

    2016-06-22

    This document outlines acceleration projects and mm-wave structure research performed at LANL. The motivation for PBG research is described first, with reference to couplers for superconducting accelerators and structures for room-temperature accelerators and W-band TWTs. These topics are then taken up in greater detail: PBG structures and the MIT PBG accelerator; SRF PBG cavities at LANL; X-band PBG cavities at LANL; and W-band PBG TWT at LANL. The presentation concludes by describing other advanced accelerator projects: beam shaping with an Emittance Exchanger, diamond field emitter array cathodes, and additive manufacturing of novel accelerator structures.

  16. Research Foundations for the Advanced Distributed Learning Initiative

    DTIC Science & Technology

    2010-08-01

    Tobias, S . (2005). The multimedia principle . In R. E. Mayer (Ed.), The Cambridge handbook of multimedia learning (pp. 117–133). New York, NY...I N S T I T U T E F O R D E F E N S E A N A LY S E S IDA Document D-4118 August 2010 Research Foundations for the Advanced Distributed Learning...requiring scientific and technical expertise, and conduct related research on other national challenges. I N S T I T U T E F O R D E F E N S E A N A L Y

  17. Advancing Research to Action in Global Child Mental Health.

    PubMed

    Ordóñez, Anna E; Collins, Pamela Y

    2015-10-01

    Most mental and substance use disorders begin during childhood and adolescence and are the leading cause of disability in this population. Prenatal and postnatal genetic, familial, social, and environmental exposures interact to influence risk for mental disorders and trajectories of cognitive development. Efforts to advance prevention and implement early interventions to reduce the burden of mental disorders require a global research workforce, intersectoral cooperation, attention to environmental contexts, and the development and testing of evidence-based interventions. The authors describe challenges and resources for building mental health research capacity that stands to influence children's mental health outcomes around the globe.

  18. Recent advances in research on climate and human conflict

    NASA Astrophysics Data System (ADS)

    Hsiang, S. M.

    2014-12-01

    A rapidly growing body of empirical, quantitative research examines whether rates of human conflict can be systematically altered by climatic changes. We discuss recent advances in this field, including Bayesian meta-analyses of the effect of temperature and rainfall on current and future large-scale conflicts, the impact of climate variables on gang violence and suicides in Mexico, and probabilistic projections of personal violence and property crime in the United States under RCP scenarios. Criticisms of this research field will also be explained and addressed.

  19. Teaching advanced science concepts through Freshman Research Immersion

    NASA Astrophysics Data System (ADS)

    Wahila, M. J.; Amey-Proper, J.; Jones, W. E.; Stamp, N.; Piper, L. F. J.

    2017-03-01

    We have developed a new introductory physics/chemistry programme that teaches advanced science topics and practical laboratory skills to freshmen undergraduate students through the use of student-led, bona fide research activities. While many recent attempts to improve college-level physics education have focused on integrating interactive demonstrations and activities into traditional passive lectures, we have taken the idea of active-learning several steps further. Working in conjunction with several research faculty at Binghamton University, we have created a programme that puts undergraduate students on an accelerated path towards working in real research laboratories performing publishable research. Herein, we describe in detail the programme goals, structure, and educational content, and report on our promising initial student outcomes.

  20. Research reactor of the future: The advanced neutron source

    SciTech Connect

    Appleton, B.; West, C.

    1994-12-31

    Agents for cancer detection and treatment, stronger materials, better electronic gadgets, and other consumer and industrial products - these are assured benefits of a research reactor project proposed for Oak Ridge. Just as American companies have again assumed world leadership in producing semiconductor chips as well as cars and trucks, the United States is poised to retake the lead in neutron science by building and operating the $2.9 billion Advanced Neutron Source (ANS) research reactor by the start of the next century. In 1985, the neutron community, led by ORNL researchers, proposed a pioneering project, later called the ANS. Scheduled to begin operation in 2003, the ANS is seen not only as a replacement for the aging HFIR and HFBR but also as the best laboratory in the world for conducting neutron-based research.

  1. Advancing Aeronautics: A Decision Framework for Selecting Research Agendas

    NASA Technical Reports Server (NTRS)

    Anton, Philip S.; Ecola, Liisa; Kallimani, James G.; Light, Thomas; Ohlandt, Chad J. R.; Osburg, Jan; Raman, Raj; Grammich, Clifford A.

    2011-01-01

    Publicly funded research has long played a role in the development of aeronautics, ranging from foundational research on airfoils to development of the air-traffic control system. Yet more than a century after the research and development of successful controlled, sustained, heavier-than-air flight vehicles, there are questions over the future of aeronautics research. The field of aeronautics is relatively mature, technological developments within it have become more evolutionary, and funding decisions are sometimes motivated by the continued pursuit of these evolutionary research tracks rather than by larger factors. These developments raise questions over whether public funding of aeronautics research continues to be appropriate or necessary and at what levels. Tightened federal budgets and increasing calls to address other public demands make these questions sharper still. To help it address the questions of appropriate directions for publicly funded aeronautics research, the National Aeronautics and Space Administration's (NASA's) Aeronautics Research Mission Directorate (ARMD) asked the RAND Corporation to assess the elements required to develop a strategic view of aeronautics research opportunities; identify candidate aeronautic grand challenges, paradigms, and concepts; outline a framework for evaluating them; and exercise the framework as an example of how to use it. Accordingly, this research seeks to address these questions: What aeronautics research should be supported by the U.S. government? What compelling and desirable benefits drive government-supported research? How should the government--especially NASA--make decisions about which research to support? Advancing aeronautics involves broad policy and decisionmaking challenges. Decisions involve tradeoffs among competing perspectives, uncertainties, and informed judgment.

  2. The advanced neutron source research and development plan

    SciTech Connect

    Selby, D.L.

    1995-08-01

    The Advanced Neutron Source (ANS) is being designed as a user-oriented neutron research laboratory centered around the most intense continuous beams of thermal and subthermal neutrons in the world (an order of magnitude more intense than beams available from the most advanced existing reactors). The ANS will be built around a new research reactor of 330-MW fission power, producing an unprecedented peak thermal flux of >7 {center_dot} 10{sup 19} {center_dot} m{sup -2} {center_dot} s{sup -1}. Primarily a research facility, the ANS will accommodate more than 1000 academic, industrial, and government researchers each year. They will conduct basic research in all branches of science as well as applied research leading to better understanding of new materials, including high temperature super conductors, plastics, and thin films. Some 48 neutron beam stations will be set up in the ANS beam rooms and the neutron guide hall for neutron scattering and for fundamental and nuclear physics research. There also will be extensive facilities for materials irradiation, isotope production, and analytical chemistry. The top level work breakdown structure (WBS) for the project. As noted in this figure, one component of the project is a research and development (R&D) program (WBS 1.1). This program interfaces with all of the other project level two WBS activities. Because one of the project guidelines is to meet minimum performance goals without relying on new inventions, this R&D activity is not intended to produce new concepts to allow the project to meet minimum performance goals. Instead, the R&D program will focus on the four objectives described.

  3. A University Consortium for the Advancement of Hydrologic Research

    NASA Astrophysics Data System (ADS)

    Hooper, R. P.; Wilson, J.; Band, L.; Reckhow, K.

    2003-12-01

    Seventy-six research universities across the United States have joined to form the Consortium of Universities for the Advancement of Hydrologic Science, Inc. (CUAHSI), a non-profit corporation. With support from the National Science Foundation, CUAHSI has embarked upon the design and development of programs to enable hydrologic research at larger spatial scales over longer time periods than has been within the grasp of individual investigators. The guiding principle of this design has been an embracing of the entire hydrologic cycle to enable research at the interfaces among traditional hydrologic subdisciplines and between hydrologic science and allied disciplines in the earth and life sciences. To improve our predictive understanding of hydrologic phenomena, the fundamental approach that has been adopted is the development of multidisciplinary, coherent data sets to enable testing of hypotheses in different hydrologic settings across a range of spatial and temporal scales. Four mutually supportive program elements have been conceived: a network of hydrologic observatories (the subject of this special session) designed strategically to collect additional data at large scales (on the order of 10,000 km2) and to leverage existing investments in small-scale intensive studies and in larger scale monitoring activities; hydrologic information systems to develop a comprehensive data model for integrating disparate data types, to develop the cyberinfrastructure necessary for systematic data collection and dissemination and to support community models; hydrologic measurement technology facility to broker instrumentation services from existing sources, to provide cutting edge tools along with the necessary support to use them, and to develop new hydrologic instrumentation needed to advance the science; and hydrologic synthesis center to provide a venue for hydrologic sciences from a range of disciplines to work on topics ranging from inter-observatory comparison to evolving

  4. Advanced Test Reactor National Scientific User Facility: Addressing advanced nuclear materials research

    SciTech Connect

    John Jackson; Todd Allen; Frances Marshall; Jim Cole

    2013-03-01

    The Advanced Test Reactor National Scientific User Facility (ATR NSUF), based at the Idaho National Laboratory in the United States, is supporting Department of Energy and industry research efforts to ensure the properties of materials in light water reactors are well understood. The ATR NSUF is providing this support through three main efforts: establishing unique infrastructure necessary to conduct research on highly radioactive materials, conducting research in conjunction with industry partners on life extension relevant topics, and providing training courses to encourage more U.S. researchers to understand and address LWR materials issues. In 2010 and 2011, several advanced instruments with capability focused on resolving nuclear material performance issues through analysis on the micro (10-6 m) to atomic (10-10 m) scales were installed primarily at the Center for Advanced Energy Studies (CAES) in Idaho Falls, Idaho. These instruments included a local electrode atom probe (LEAP), a field-emission gun scanning transmission electron microscope (FEG-STEM), a focused ion beam (FIB) system, a Raman spectrometer, and an nanoindentor/atomic force microscope. Ongoing capability enhancements intended to support industry efforts include completion of two shielded, irradiation assisted stress corrosion cracking (IASCC) test loops, the first of which will come online in early calendar year 2013, a pressurized and controlled chemistry water loop for the ATR center flux trap, and a dedicated facility intended to house post irradiation examination equipment. In addition to capability enhancements at the main site in Idaho, the ATR NSUF also welcomed two new partner facilities in 2011 and two new partner facilities in 2012; the Oak Ridge National Laboratory, High Flux Isotope Reactor (HFIR) and associated hot cells and the University California Berkeley capabilities in irradiated materials analysis were added in 2011. In 2012, Purdue University’s Interaction of Materials

  5. Advanced Radioisotope Power Conversion Technology Research and Development

    NASA Technical Reports Server (NTRS)

    Wong, Wayne A.

    2004-01-01

    NASA's Radioisotope Power Conversion Technology program is developing next generation power conversion technologies that will enable future missions that have requirements that cannot be met by either the ubiquitous photovoltaic systems or by current Radioisotope Power System (RPS) technology. Performance goals of advanced radioisotope power systems include improvement over the state-of-practice General Purpose Heat Source/Radioisotope Thermoelectric Generator by providing significantly higher efficiency to reduce the number of radioisotope fuel modules, and increase specific power (watts/kilogram). Other Advanced RPS goals include safety, long-life, reliability, scalability, multi-mission capability, resistance to radiation, and minimal interference with the scientific payload. NASA has awarded ten contracts in the technology areas of Brayton, Stirling, Thermoelectric, and Thermophotovoltaic power conversion including five development contracts that deal with more mature technologies and five research contracts. The Advanced RPS Systems Assessment Team includes members from NASA GRC, JPL, DOE and Orbital Sciences whose function is to review the technologies being developed under the ten Radioisotope Power Conversion Technology contracts and assess their relevance to NASA's future missions. Presented is an overview of the ten radioisotope power conversion technology contracts and NASA's Advanced RPS Systems Assessment Team.

  6. Design method of automotive powertrain mounting system based on vibration and noise limitations of vehicle level

    NASA Astrophysics Data System (ADS)

    Shangguan, Wen-Bin; Liu, Xiao-Ang; Lv, Zhao-Ping; Rakheja, Subhash

    2016-08-01

    The design logic and calculation method for determining mount stiffness and damping for a Powertrain Mounting System (PMS) based on reductions of vehicle vibration and noise contributed by mounts is proposed in this paper. Firstly, the design target for a PMS with regard to vibration and noise limitations of vehicle level contributed form mounts is described. Then a vehicle model with 13 Degree of Freedoms (DOFs) is proposed, which includes 6DOFs for the powertrain, 3 DOFs for the car body and 4DOFs for the four unsprung mass, and the dynamic equation for the model is derived. Some widely used models, such as the 6 DOFs model of the powertrain for the design calculation of a PMS, the 7 DOFs model (Body's 3 DOFs; unsprung mass's 4 DOFs) and the 9 DOFs model (powertrain's 6 DOFs; Body's 3 DOFs) for ride analysis of a vehicle, are the specific cases of the presented model of 13 DOF. Thirdly, the calculation method for obtaining the vibration of seat track and evaluation point and the noise at driver right ear is presented based on the mount forces and the vibration and noise transfer functions. An optimization process is proposed to get the mount stiffness and damping based on minimization of vehicle vibration and noise, and the optimized stiffness is validated by comparing the calculated vibration and noise and limitations. In the end of this paper, the natural frequencies and mode energies for the powertrain, the body and the unsprung mass are calculated using different models and the results are compared and analyzed.

  7. Facing up to the Challenges of Advancing Craniofacial Research

    PubMed Central

    Trainor, Paul A.; Richtsmeier, Joan T.

    2015-01-01

    Craniofacial anomalies are among the most common human birth defects and have considerable functional, aesthetic, and social consequences. The early developmental origin as well as the anatomical complexity of the head and face render these tissues prone to genetic and environmental insult. The establishment of craniofacial clinics offering comprehensive care for craniofacial patients at a single site together with international research networks focused on the origins and treatment of craniofacial disorders has led to tremendous advances in our understanding of the etiology and pathogenesis of congenital craniofacial anomalies. However, the genetic, environmental, and developmental sources of many craniofacial disorders remain unknown. To overcome this problem and further advance craniofacial research, we must recognize current challenges in the field and establish priority areas for study. We still need (i) a deeper understanding of variation during normal development and within the context of any disorder, (ii) improved genotyping and phenotyping and understanding of the impact of epigenetics, (iii) continued development of animal models and functional analyses of genes and variants, and (iv) integration of patient derived cells and tissues together with 3D printing and quantitative assessment of surgical outcomes for improved practice. Only with fundamental advances in each of these areas will we be able to meet the challenge of translating potential therapeutic and preventative approaches into clinical solutions and reduce the financial and emotional burden of craniofacial anomalies. PMID:25820983

  8. Simulated Interactive Research Experiments as Educational Tools for Advanced Science.

    PubMed

    Tomandl, Mathias; Mieling, Thomas; Losert-Valiente Kroon, Christiane M; Hopf, Martin; Arndt, Markus

    2015-09-15

    Experimental research has become complex and thus a challenge to science education. Only very few students can typically be trained on advanced scientific equipment. It is therefore important to find new tools that allow all students to acquire laboratory skills individually and independent of where they are located. In a design-based research process we have investigated the feasibility of using a virtual laboratory as a photo-realistic and scientifically valid representation of advanced scientific infrastructure to teach modern experimental science, here, molecular quantum optics. We found a concept based on three educational principles that allows undergraduate students to become acquainted with procedures and concepts of a modern research field. We find a significant increase in student understanding using our Simulated Interactive Research Experiment (SiReX), by evaluating the learning outcomes with semi-structured interviews in a pre/post design. This suggests that this concept of an educational tool can be generalized to disseminate findings in other fields.

  9. Simulated Interactive Research Experiments as Educational Tools for Advanced Science

    PubMed Central

    Tomandl, Mathias; Mieling, Thomas; Losert-Valiente Kroon, Christiane M.; Hopf, Martin; Arndt, Markus

    2015-01-01

    Experimental research has become complex and thus a challenge to science education. Only very few students can typically be trained on advanced scientific equipment. It is therefore important to find new tools that allow all students to acquire laboratory skills individually and independent of where they are located. In a design-based research process we have investigated the feasibility of using a virtual laboratory as a photo-realistic and scientifically valid representation of advanced scientific infrastructure to teach modern experimental science, here, molecular quantum optics. We found a concept based on three educational principles that allows undergraduate students to become acquainted with procedures and concepts of a modern research field. We find a significant increase in student understanding using our Simulated Interactive Research Experiment (SiReX), by evaluating the learning outcomes with semi-structured interviews in a pre/post design. This suggests that this concept of an educational tool can be generalized to disseminate findings in other fields. PMID:26370627

  10. EarthCube Activities: Community Engagement Advancing Geoscience Research

    NASA Astrophysics Data System (ADS)

    Kinkade, D.

    2015-12-01

    Our ability to advance scientific research in order to better understand complex Earth systems, address emerging geoscience problems, and meet societal challenges is increasingly dependent upon the concept of Open Science and Data. Although these terms are relatively new to the world of research, Open Science and Data in this context may be described as transparency in the scientific process. This includes the discoverability, public accessibility and reusability of scientific data, as well as accessibility and transparency of scientific communication (www.openscience.org). Scientists and the US government alike are realizing the critical need for easy discovery and access to multidisciplinary data to advance research in the geosciences. The NSF-supported EarthCube project was created to meet this need. EarthCube is developing a community-driven common cyberinfrastructure for the purpose of accessing, integrating, analyzing, sharing and visualizing all forms of data and related resources through advanced technological and computational capabilities. Engaging the geoscience community in EarthCube's development is crucial to its success, and EarthCube is providing several opportunities for geoscience involvement. This presentation will provide an overview of the activities EarthCube is employing to entrain the community in the development process, from governance development and strategic planning, to technical needs gathering. Particular focus will be given to the collection of science-driven use cases as a means of capturing scientific and technical requirements. Such activities inform the development of key technical and computational components that collectively will form a cyberinfrastructure to meet the research needs of the geoscience community.

  11. Los Alamos NEP research in advanced plasma thrusters

    NASA Technical Reports Server (NTRS)

    Schoenberg, Kurt; Gerwin, Richard

    1991-01-01

    Research was initiated in advanced plasma thrusters that capitalizes on lab capabilities in plasma science and technology. The goal of the program was to examine the scaling issues of magnetoplasmadynamic (MPD) thruster performance in support of NASA's MPD thruster development program. The objective was to address multi-megawatt, large scale, quasi-steady state MPD thruster performance. Results to date include a new quasi-steady state operating regime which was obtained at space exploration initiative relevant power levels, that enables direct coaxial gun-MPD comparisons of thruster physics and performance. The radiative losses are neglible. Operation with an applied axial magnetic field shows the same operational stability and exhaust plume uniformity benefits seen in MPD thrusters. Observed gun impedance is in close agreement with the magnetic Bernoulli model predictions. Spatial and temporal measurements of magnetic field, electric field, plasma density, electron temperature, and ion/neutral energy distribution are underway. Model applications to advanced mission logistics are also underway.

  12. Advances in Inner Magnetosphere Passive and Active Wave Research

    NASA Technical Reports Server (NTRS)

    Green, James L.; Fung, Shing F.

    2004-01-01

    This review identifies a number of the principal research advancements that have occurred over the last five years in the study of electromagnetic (EM) waves in the Earth's inner magnetosphere. The observations used in this study are from the plasma wave instruments and radio sounders on Cluster, IMAGE, Geotail, Wind, Polar, Interball, and others. The data from passive plasma wave instruments have led to a number of advances such as: determining the origin and importance of whistler mode waves in the plasmasphere, discovery of the source of kilometric continuum radiation, mapping AKR source regions with "pinpoint" accuracy, and correlating the AKR source location with dipole tilt angle. Active magnetospheric wave experiments have shown that long range ducted and direct echoes can be used to obtain the density distribution of electrons in the polar cap and along plasmaspheric field lines, providing key information on plasmaspheric filling rates and polar cap outflows.

  13. Advanced NDE research in electromagnetic, thermal, and coherent optics

    NASA Astrophysics Data System (ADS)

    Skinner, S. Ballou

    1992-09-01

    A new inspection technology called magneto-optic/eddy current imaging was investigated. The magneto-optic imager makes readily visible irregularities and inconsistencies in airframe components. Other research observed in electromagnetics included (1) disbond detection via resonant modal analysis; (2) AC magnetic field frequency dependence of magnetoacoustic emission; and (3) multi-view magneto-optic imaging. Research observed in the thermal group included (1) thermographic detection and characterization of corrosion in aircraft aluminum; (2) a multipurpose infrared imaging system for thermoelastic stress detection; (3) thermal diffusivity imaging of stress induced damage in composites; and (4) detection and measurement of ice formation on the space shuttle main fuel tank. Research observed in the optics group included advancements in optical nondestructive evaluation (NDE).

  14. Assessment of Research Needs for Advanced Fuel Cells

    SciTech Connect

    Penner, S.S.

    1985-11-01

    The DOE Advanced Fuel Cell Working Group (AFCWG) was formed and asked to perform a scientific evaluation of the current status of fuel cells, with emphasis on identification of long-range research that may have a significant impact on the practical utilization of fuel cells in a variety of applications. The AFCWG held six meetings at locations throughout the country where fuel cell research and development are in progress, for presentations by experts on the status of fuel cell research and development efforts, as well as for inputs on research needs. Subsequent discussions by the AFCWG have resulted in the identification of priority research areas that should be explored over the long term in order to advance the design and performance of fuel cells of all types. Surveys describing the salient features of individual fuel cell types are presented in Chapters 2 to 6 and include elaborations of long-term research needs relating to the expeditious introduction of improved fuel cells. The Introduction and the Summary (Chapter 1) were prepared by AFCWG. They were repeatedly revised in response to comments and criticism. The present version represents the closest approach to a consensus that we were able to reach, which should not be interpreted to mean that each member of AFCWG endorses every statement and every unexpressed deletion. The Introduction and Summary always represent a majority view and, occasionally, a unanimous judgment. Chapters 2 to 6 provide background information and carry the names of identified authors. The identified authors of Chapters 2 to 6, rather than AFCWG as a whole, bear full responsibility for the scientific and technical contents of these chapters.

  15. Advancing the field of health systems research synthesis.

    PubMed

    Langlois, Etienne V; Ranson, Michael K; Bärnighausen, Till; Bosch-Capblanch, Xavier; Daniels, Karen; El-Jardali, Fadi; Ghaffar, Abdul; Grimshaw, Jeremy; Haines, Andy; Lavis, John N; Lewin, Simon; Meng, Qingyue; Oliver, Sandy; Pantoja, Tomás; Straus, Sharon; Shemilt, Ian; Tovey, David; Tugwell, Peter; Waddington, Hugh; Wilson, Mark; Yuan, Beibei; Røttingen, John-Arne

    2015-07-10

    Those planning, managing and working in health systems worldwide routinely need to make decisions regarding strategies to improve health care and promote equity. Systematic reviews of different kinds can be of great help to these decision-makers, providing actionable evidence at every step in the decision-making process. Although there is growing recognition of the importance of systematic reviews to inform both policy decisions and produce guidance for health systems, a number of important methodological and evidence uptake challenges remain and better coordination of existing initiatives is needed. The Alliance for Health Policy and Systems Research, housed within the World Health Organization, convened an Advisory Group on Health Systems Research (HSR) Synthesis to bring together different stakeholders interested in HSR synthesis and its use in decision-making processes. We describe the rationale of the Advisory Group and the six areas of its work and reflects on its role in advancing the field of HSR synthesis. We argue in favour of greater cross-institutional collaborations, as well as capacity strengthening in low- and middle-income countries, to advance the science and practice of health systems research synthesis. We advocate for the integration of quasi-experimental study designs in reviews of effectiveness of health systems intervention and reforms. The Advisory Group also recommends adopting priority-setting approaches for HSR synthesis and increasing the use of findings from systematic reviews in health policy and decision-making.

  16. Twelfth International Symposium on Recent Advances in Environmental Health Research.

    PubMed

    Tchounwou, Paul B

    2016-05-04

    During the past century, environmental hazards have become a major concern, not only to public health professionals, but also to the society at large because of their tremendous health, socio-cultural and economic impacts. Various anthropogenic or natural factors have been implicated in the alteration of ecosystem integrity, as well as in the development of a wide variety of acute and/or chronic diseases in humans. It has also been demonstrated that many environmental agents, acting either independently or in combination with other toxins, may induce a wide range of adverse health outcomes. Understanding the role played by the environment in the etiology of human diseases is critical to designing cost-effective control/prevention measures. This special issue of International Journal of Environmental Research and Public Health includes the proceedings of the Twelfth International Symposium on Recent Advances in Environmental Health Research. The Symposium provided an excellent opportunity to discuss the scientific advances in biomedical, environmental, and public health research that addresses global environmental health issues.

  17. Recent trends and advances in berry health benefits research.

    PubMed

    Seeram, Navindra P

    2010-04-14

    Recent advances have been made in our scientific understanding of how berries promote human health and prevent chronic illnesses such as some cancers, heart disease, and neurodegenerative diseases. Cancer is rapidly overtaking heart disease as the number one killer disease in developed countries, and this phenomenon is coupled with a growing aging population and concomitant age-related diseases. Therefore, it is not surprising that consumers are turning toward foods with medicinal properties as promising dietary interventions for disease prevention and health maintenance. Among fruits, berries of all colors have emerged as champions with substantial research data supporting their abilities to positively affect multiple disease states. Apart from several essential dietary components found in berries, such as vitamins, minerals, and fiber, berries also contain numerous bioactives that provide health benefits that extend beyond basic nutrition. Berry bioactives encompass a wide diversity of phytochemicals (phytonutrients) ranging from fat-soluble/lipophilic to water-soluble/hydrophilic compounds. Recent research from laboratories across the globe has provided useful insights into the biological effects and underlying mechanisms of actions resulting from eating berries. The cluster of papers included here represents a cross section of topics discussed at the 2009 International Berry Health Benefits Symposium. Together, these papers provide valuable insight into recent research trends and advances made into evaluating the various health benefits that may result from the consumption of berries and their derived products.

  18. Twelfth International Symposium on Recent Advances in Environmental Health Research

    PubMed Central

    Tchounwou, Paul B.

    2016-01-01

    During the past century, environmental hazards have become a major concern, not only to public health professionals, but also to the society at large because of their tremendous health, socio-cultural and economic impacts. Various anthropogenic or natural factors have been implicated in the alteration of ecosystem integrity, as well as in the development of a wide variety of acute and/or chronic diseases in humans. It has also been demonstrated that many environmental agents, acting either independently or in combination with other toxins, may induce a wide range of adverse health outcomes. Understanding the role played by the environment in the etiology of human diseases is critical to designing cost-effective control/prevention measures. This special issue of International Journal of Environmental Research and Public Health includes the proceedings of the Twelfth International Symposium on Recent Advances in Environmental Health Research. The Symposium provided an excellent opportunity to discuss the scientific advances in biomedical, environmental, and public health research that addresses global environmental health issues. PMID:27153079

  19. [The research advance of brain derived neurotrophic factor].

    PubMed

    Liu, Z; Chen, J

    2000-12-01

    Recent research advances in neuroscience show that neurotrophic factors are proteins that affect selectively various kinds of neurons of CNS and PNS. Brain derived neurotrophic factor (BDNF) is another neurotrophic factor that was first reported by Barde, a German chemist, thirty years later after the nerve growth factor had been found out. BDNF plays an important role in the growth, development, differentiation, maintenance and regeneration of various types of neurons in the CNS and has potential application to the treatment of brain injury and neurodegenerative diseases such as Alzheimer's disease, Parkinson's syndrome, Huntington's chorea and amyotrophic lateral sclerosis. In this paper, the structure, function and potential clinical application of BDNF were reviewed.

  20. Impact of new instrumentation on advanced turbine research

    NASA Technical Reports Server (NTRS)

    Graham, R. W.

    1980-01-01

    A description is presented of an orderly test program that progresses from the simplest stationary geometry to the more complex, three dimensional, rotating turbine stage. The instrumentation requirements for this evolution of testing are described. The heat transfer instrumentation is emphasized. Recent progress made in devising new measurement techniques has greatly improved the development and confirmation of more accurate analytical methods for the prediction of turbine performance and heat transfer. However, there remain challenging requirements for novel measurement techniques that could advance the future research to be done in rotating blade rows of turbomachines.

  1. Advanced computational research in materials processing for design and manufacturing

    SciTech Connect

    Zacharia, T.

    1994-12-31

    The computational requirements for design and manufacture of automotive components have seen dramatic increases for producing automobiles with three times the mileage. Automotive component design systems are becoming increasingly reliant on structural analysis requiring both overall larger analysis and more complex analyses, more three-dimensional analyses, larger model sizes, and routine consideration of transient and non-linear effects. Such analyses must be performed rapidly to minimize delays in the design and development process, which drives the need for parallel computing. This paper briefly describes advanced computational research in superplastic forming and automotive crash worthiness.

  2. [Markers of prostate cancer stem cells: research advances].

    PubMed

    Wang, Shun-Qi; Huang, Sheng-Song

    2013-12-01

    Prostate cancer is one of the most seriously malignant diseases threatening men's health, and the mechanisms of its initiation and progression are not yet completely understood. Recent years have witnessed distinct advances in researches on prostate cancer stem cells in many aspects using different sources of materials, such as human prostate cancer tissues, human prostate cancer cell lines, and mouse models of prostate cancer. Prostate cancer stem cell study offers a new insight into the mechanisms of the initiation and progression of prostate cancer and contributes positively to its treatment. This article presents an overview on the prostate cancer stem cell markers utilized in the isolation and identification of prostate cancer stem cells.

  3. Oklahoma State University proposed Advanced Technology Research Center. Environmental Assessment

    SciTech Connect

    1995-06-01

    The Department of Energy (DOE) has prepared an Environmental Assessment (EA) evaluating the construction and equipping of the proposed Advanced Technology Research Center (ATRC) at Oklahoma State University (OSU) in Stillwater, Oklahoma. Based on the analysis in the EA, the DOE has determined that the proposed action does not constitute a major federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act (NEPA) of 1969. Therefore, the preparation of an Environmental Impact Statement is not required.

  4. Oil shale, tar sand, coal research, advanced exploratory process technology jointly sponsored research

    SciTech Connect

    Not Available

    1992-01-01

    Accomplishments for the quarter are presented for the following areas of research: oil shale, tar sand, coal, advanced exploratory process technology, and jointly sponsored research. Oil shale research includes; oil shale process studies, environmental base studies for oil shale, and miscellaneous basic concept studies. Tar sand research covers process development. Coal research includes; underground coal gasification, coal combustion, integrated coal processing concepts, and solid waste management. Advanced exploratory process technology includes; advanced process concepts, advanced mitigation concepts, and oil and gas technology. Jointly sponsored research includes: organic and inorganic hazardous waste stabilization; development and validation of a standard test method for sequential batch extraction fluid; operation and evaluation of the CO[sub 2] HUFF-N-PUFF Process; fly ash binder for unsurfaced road aggregates; solid state NMR analysis of Mesa Verde Group, Greater Green River Basin, tight gas sands; flow-loop testing of double-wall pipe for thermal applications; characterization of petroleum residue; shallow oil production using horizontal wells with enhanced recovery techniques; and menu driven access to the WDEQ Hydrologic Data Management Systems.

  5. Major clinical research advances in gynecologic cancer in 2015

    PubMed Central

    2016-01-01

    In 2015, fourteen topics were selected as major research advances in gynecologic oncology. For ovarian cancer, high-level evidence for annual screening with multimodal strategy which could reduce ovarian cancer deaths was reported. The best preventive strategies with current status of evidence level were also summarized. Final report of chemotherapy or upfront surgery (CHORUS) trial of neoadjuvant chemotherapy in advanced stage ovarian cancer and individualized therapy based on gene characteristics followed. There was no sign of abating in great interest in immunotherapy as well as targeted therapies in various gynecologic cancers. The fifth Ovarian Cancer Consensus Conference which was held in November 7–9 in Tokyo was briefly introduced. For cervical cancer, update of human papillomavirus vaccines regarding two-dose regimen, 9-valent vaccine, and therapeutic vaccine was reviewed. For corpus cancer, the safety concern of power morcellation in presumed fibroids was explored again with regard to age and prevalence of corpus malignancy. Hormone therapy and endometrial cancer risk, trabectedin as an option for leiomyosarcoma, endometrial cancer and Lynch syndrome, and the radiation therapy guidelines were also discussed. In addition, adjuvant therapy in vulvar cancer and the updated of targeted therapy in gynecologic cancer were addressed. For breast cancer, palbociclib in hormone-receptor-positive advanced disease, oncotype DX Recurrence Score in low-risk patients, regional nodal irradiation to internal mammary, supraclavicular, and axillary lymph nodes, and cavity shave margins were summarized as the last topics covered in this review. PMID:27775259

  6. Major clinical research advances in gynecologic cancer in 2015.

    PubMed

    Suh, Dong Hoon; Kim, Miseon; Kim, Hak Jae; Lee, Kyung Hun; Kim, Jae Weon

    2016-11-01

    In 2015, fourteen topics were selected as major research advances in gynecologic oncology. For ovarian cancer, high-level evidence for annual screening with multimodal strategy which could reduce ovarian cancer deaths was reported. The best preventive strategies with current status of evidence level were also summarized. Final report of chemotherapy or upfront surgery (CHORUS) trial of neoadjuvant chemotherapy in advanced stage ovarian cancer and individualized therapy based on gene characteristics followed. There was no sign of abating in great interest in immunotherapy as well as targeted therapies in various gynecologic cancers. The fifth Ovarian Cancer Consensus Conference which was held in November 7-9 in Tokyo was briefly introduced. For cervical cancer, update of human papillomavirus vaccines regarding two-dose regimen, 9-valent vaccine, and therapeutic vaccine was reviewed. For corpus cancer, the safety concern of power morcellation in presumed fibroids was explored again with regard to age and prevalence of corpus malignancy. Hormone therapy and endometrial cancer risk, trabectedin as an option for leiomyosarcoma, endometrial cancer and Lynch syndrome, and the radiation therapy guidelines were also discussed. In addition, adjuvant therapy in vulvar cancer and the updated of targeted therapy in gynecologic cancer were addressed. For breast cancer, palbociclib in hormone-receptor-positive advanced disease, oncotype DX Recurrence Score in low-risk patients, regional nodal irradiation to internal mammary, supraclavicular, and axillary lymph nodes, and cavity shave margins were summarized as the last topics covered in this review.

  7. Advanced Stirling Technology Development at NASA Glenn Research Center

    NASA Technical Reports Server (NTRS)

    Shaltens, Richard K.; Wong, Wayne A.

    2007-01-01

    The NASA Glenn Research Center has been developing advanced energy-conversion technologies for use with both radioisotope power systems and fission surface power systems for many decades. Under NASA's Science Mission Directorate, Planetary Science Theme, Technology Program, Glenn is developing the next generation of advanced Stirling convertors (ASCs) for use in the Department of Energy/Lockheed Martin Advanced Stirling Radioisotope Generator (ASRG). The next-generation power-conversion technologies require high efficiency and high specific power (watts electric per kilogram) to meet future mission requirements to use less of the Department of Energy's plutonium-fueled general-purpose heat source modules and reduce system mass. Important goals include long-life (greater than 14-yr) reliability and scalability so that these systems can be considered for a variety of future applications and missions including outer-planet missions and continual operation on the surface of Mars. This paper provides an update of the history and status of the ASC being developed for Glenn by Sunpower Inc. of Athens, Ohio.

  8. Opportunities for Condensed Matter Research at the Advanced Photon Source

    NASA Astrophysics Data System (ADS)

    Gibson, J. Murray

    2004-03-01

    The Advanced Photon Source is the Western Hemisphere's most brilliant source of x-rays. This 3rd-generation 7-GeV synchrotron source can accomodate 34 insertion device ports, of which 30 are committed, and 24 are currently operating. In Fiscal Year 2002, we had 2767 unique users carry out at least one experiment at the source, of which 35research in materials science or condensed matter physics. Techniques commonly used by condensed matter scientists include single-crystal and powder diffraction, high-pressure studies, inelastic scattering, absorption and fluorescence spectroscopy, magnetic scattering and fluctuation spectroscopy. Access to the Advanced Photon Source can be either as a general user (www.aps.anl.gov) or as a partner user. Proposals from general users are encouraged, and beamtime is granted based on competitive review. Our capacity to accomodate more general users continues to increase. Typically, partner users build specialized equipment which is made available to general users. Many of our sectors have been built and operated by external Collaborative Access Teams, which support general users who enter through the APS centralized system. With the help of partnerships, the APS continues to evolve state-of-the-art beamlines of interest to condensed matter scientists, in areas such as inelastic scattering and nano-imaging. The Advanced Photon Source is closely connected with the new Center for Nanoscale Materials User Facility at Argonne. In this talk I will present notable examples of recent condensed matter physics experiments which utilized the unique capabilities of existing beamlines, and discuss future beamlines at the Advanced Photon Source.

  9. A changing landscape for advance directives in dementia research.

    PubMed

    Pierce, Robin

    2010-02-01

    The number of persons afflicted by dementia has increased steadily. The need for research leading to diagnostic and therapeutic interventions is widely recognized. However, dementia patients eventually lose the capacity to consent to the very research that could lead to discoveries of effective interventions. Worldwide, surrogate decision-making remains the primary means of consent for this population. This significantly restricts the autonomy of competent patients who wish to prospectively consent to research and do not wish to relinquish this decision to a third party. Advance research directives (ARDs) have been proposed as a mechanism for prospective consent for persons who anticipate cognitive impairment, as in the case of prodromal or early stage dementia patients. Currently, few guidelines specifically address the use of ARDs despite calls for official recognition. This absence of official guidelines regarding ARDs renders this mechanism susceptible to misuse, under-use, or non-use in instances where it could be advantageous for individuals, their families/caregivers, and progress in dementia research and treatment. This paper explores the changing landscape of ARDs, identifying relevant scientific, social, and policy developments, and queries whether, under these circumstances, reticence to use, recognize, or regulate ARDs is justified. It addresses some of the persistent issues related to vulnerability, the role of surrogates, and scope of prospective consent, and concludes that ARDs can serve as an important mechanism of autonomy and empowerment, and that protections should be crafted such that the availability of this option is not limited to those who also appoint a surrogate.

  10. [Research advances in methyl bromide in the ocean].

    PubMed

    Du, Hui-na; Xie, Wen-xia; Cui, Yu-qian; Chen, Jian-lei; Ye, Si-yuan

    2014-12-01

    Methyl bromide is an important atmospheric trace gas, which plays significant roles in the global warming and atmospheric chemistry. The ocean plays important and complex roles in the global biogeochemical cycles of methyl bromide, not only the source of atmospheric methyl bromide, but also the sink. Therefore, developing the chemical research of the soluble methyl bromide in the ocean, will not only have a certain guiding significance to the atmospheric ozone layer protection, but also provide a theoretical basis for estimating methyl bromide's contribution to the global environmental change on global scale. This paper reviewed the research advances on methyl bromide in the ocean, from the aspects of the biogeochemical cycle of methyl bromide in the ocean, the analysis and determination method, the concentration distribution, the sea-to-air flux and its sources and sinks in the atmosphere. Some deficiencies in the current studies were put forward, and the directions of the future studies were prospected.

  11. PREFACE: 7th EEIGM International Conference on Advanced Materials Research

    NASA Astrophysics Data System (ADS)

    Joffe, Roberts

    2013-12-01

    The 7th EEIGM Conference on Advanced Materials Research (AMR 2013) was held at Luleå University of Technology on the 21-22 March 2013 in Luleå, SWEDEN. This conference is intended as a meeting place for researchers involved in the EEIGM programme, in the 'Erasmus Mundus' Advanced Materials Science and Engineering Master programme (AMASE) and the 'Erasmus Mundus' Doctoral Programme in Materials Science and Engineering (DocMASE). This is great opportunity to present their on-going research in the various fields of Materials Science and Engineering, exchange ideas, strengthen co-operation as well as establish new contacts. More than 60 participants representing six countries attended the meeting, in total 26 oral talks and 19 posters were presented during two days. This issue of IOP Conference Series: Materials Science and Engineering presents a selection of articles from EEIGM-7 conference. Following tradition from previous EEIGM conferences, it represents the interdisciplinary nature of Materials Science and Engineering. The papers presented in this issue deal not only with basic research but also with applied problems of materials science. The presented topics include theoretical and experimental investigations on polymer composite materials (synthetic and bio-based), metallic materials and ceramics, as well as nano-materials of different kind. Special thanks should be directed to the senior staff of Division of Materials Science at LTU who agreed to review submitted papers and thus ensured high scientific level of content of this collection of papers. The following colleagues participated in the review process: Professor Lennart Walström, Professor Roberts Joffe, Professor Janis Varna, Associate Professor Marta-Lena Antti, Dr Esa Vuorinen, Professor Aji Mathew, Professor Alexander Soldatov, Dr Andrejs Purpurs, Dr Yvonne Aitomäki, Dr Robert Pederson. Roberts Joffe October 2013, Luleå Conference photograph EEIGM7 conference participants, 22 March 2013 The PDF

  12. Research advances on potential neurotoxicity of quantum dots.

    PubMed

    Wu, Tianshu; Zhang, Ting; Chen, Yilu; Tang, Meng

    2016-03-01

    With rapid development of nanotechnology, quantum dots (QDs) as advanced nanotechnology products have been widely used in biological and biomedical studies, including neuroscience, due to their superior optical properties. In recent years, there has been intense concern regarding the toxicity of QDs with a growing number of studies. However, the knowledge of neurotoxic consequences of QDs applied in living organisms is lagging behind their development, while a potential risk of neurotoxicity arises if mass production of QDs leads to increased exposure and distribution in the nervous system. Owing to the quantum size effect of QDs, they are capable of crossing the blood-brain barrier or moving along neural pathways and entering the brain. Nevertheless, the interactions of QDs with cells and tissues in the central nervous system are not well understood. This review highlighted research advances on the neurotoxicity of QDs in the central nervous system, including oxidative stress injury, elevated cytoplasmic Ca(2+) levels and autophagy to damage in vitro neural cells, and impairments of synaptic transmission and plasticity as well as brain functions in tested animals, with the hope of throwing light on future research directions of QD neurotoxicity, which is a demanding topic that requires further exploration.

  13. Advanced Virtual Reality Simulations in Aerospace Education and Research

    NASA Astrophysics Data System (ADS)

    Plotnikova, L.; Trivailo, P.

    2002-01-01

    Recent research developments at Aerospace Engineering, RMIT University have demonstrated great potential for using Virtual Reality simulations as a very effective tool in advanced structures and dynamics applications. They have also been extremely successful in teaching of various undergraduate and postgraduate courses for presenting complex concepts in structural and dynamics designs. Characteristic examples are related to the classical orbital mechanics, spacecraft attitude and structural dynamics. Advanced simulations, reflecting current research by the authors, are mainly related to the implementation of various non-linear dynamic techniques, including using Kane's equations to study dynamics of space tethered satellite systems and the Co-rotational Finite Element method to study reconfigurable robotic systems undergoing large rotations and large translations. The current article will describe the numerical implementation of the modern methods of dynamics, and will concentrate on the post-processing stage of the dynamic simulations. Numerous examples of building Virtual Reality stand-alone animations, designed by the authors, will be discussed in detail. These virtual reality examples will include: The striking feature of the developed technology is the use of the standard mathematical packages, like MATLAB, as a post-processing tool to generate Virtual Reality Modelling Language files with brilliant interactive, graphics and audio effects. These stand-alone demonstration files can be run under Netscape or Microsoft Explorer and do not require MATLAB. Use of this technology enables scientists to easily share their results with colleagues using the Internet, contributing to the flexible learning development at schools and Universities.

  14. Oil shale, tar sand, coal research advanced exploratory process technology, jointly sponsored research

    SciTech Connect

    Speight, J.G.

    1992-01-01

    Accomplishments for the past quarter are presented for the following five tasks: oil shale; tar sand; coal; advanced exploratory process technology; and jointly sponsored research. Oil shale research covers oil shale process studies. Tar sand research is on process development of Recycle Oil Pyrolysis and Extraction (ROPE) Process. Coal research covers: coal combustion; integrated coal processing concepts; and solid waste management. Advanced exploratory process technology includes: advanced process concepts;advanced mitigation concepts; and oil and gas technology. Jointly sponsored research includes: organic and inorganic hazardous waste stabilization; CROW field demonstration with Bell Lumber and Pole; development and validation of a standard test method for sequential batch extraction fluid; PGI demonstration project; operation and evaluation of the CO[sub 2] HUFF-N-PUFF Process; fly ash binder for unsurfaced road aggregates; solid state NMR analysis of Mesaverde Group, Greater Green River Basin, tight gas sands; flow-loop testing of double-wall pipe for thermal applications; characterization of petroleum residue; shallow oil production using horizontal wells with enhanced oil recovery techniques; surface process study for oil recovery using a thermal extraction process; NMR analysis of samples from the ocean drilling program; in situ treatment of manufactured gas plant contaminated soils demonstration program; and solid state NMR analysis of naturally and artificially matured kerogens.

  15. Area Reports. Advanced materials and devices research area. Silicon materials research task, and advanced silicon sheet task

    NASA Technical Reports Server (NTRS)

    1986-01-01

    The objectives of the Silicon Materials Task and the Advanced Silicon Sheet Task are to identify the critical technical barriers to low-cost silicon purification and sheet growth that must be overcome to produce a PV cell substrate material at a price consistent with Flat-plate Solar Array (FSA) Project objectives and to overcome these barriers by performing and supporting appropriate R&D. Progress reports are given on silicon refinement using silane, a chemical vapor transport process for purifying metallurgical grade silicon, silicon particle growth research, and modeling of silane pyrolysis in fluidized-bed reactors.

  16. The Advanced Neutron Source research and development plan

    SciTech Connect

    Selby, D.L.

    1992-11-30

    The Advanced Neutron Source (ANS) is being designed as a user-oriented neutron research laboratory centered around the most intense continuous beams of thermal and subthermal neutrons in the world. The ANS will be built around a new research reactor of [approximately] 330 MW fission power, producing an unprecedented peak thermal flux of > 7 [times] 10[sup 19] M[sup [minus]2] [center dot] S[sup [minus]1]. Primarily a research facility, the ANS will accommodate more than 1000 academic, industrial, and government researchers each year. They will conduct basic research in all branches of science-as well as applied research-leading to better understanding of new materials, including high temperature super conductors, plastics, and thin films. Some 48 neutron beam stations will be set up in the ANS beam rooms and the neutron guide hall for neutron scattering and for fundamental and nuclear physics research. There also will be extensive facilities for materials irradiation, isotope production, and analytical chemistry. The R D program will focus on the four objectives: Address feasibility issues; provide analysis support; evaluate options for improvement in performance beyond minimum requirements; and provide prototype demonstrations for unique facilities. The remainder of this report presents (1) the process by which the R D activities are controlled and (2) a discussion of the individual tasks that have been identified for the R D program, including their justification, schedule and costs. The activities discussed in this report will be performed by Martin Marietta Energy Systems, Inc. (MMES) through the Oak Ridge National Laboratory (ORNL) and through subcontracts with industry, universities, and other national laboratories. It should be noted that in general a success path has been assumed for all tasks.

  17. The Advanced Neutron Source research and development plan

    SciTech Connect

    Selby, D.L.

    1992-11-30

    The Advanced Neutron Source (ANS) is being designed as a user-oriented neutron research laboratory centered around the most intense continuous beams of thermal and subthermal neutrons in the world. The ANS will be built around a new research reactor of {approximately} 330 MW fission power, producing an unprecedented peak thermal flux of > 7 {times} 10{sup 19} M{sup {minus}2} {center_dot} S{sup {minus}1}. Primarily a research facility, the ANS will accommodate more than 1000 academic, industrial, and government researchers each year. They will conduct basic research in all branches of science-as well as applied research-leading to better understanding of new materials, including high temperature super conductors, plastics, and thin films. Some 48 neutron beam stations will be set up in the ANS beam rooms and the neutron guide hall for neutron scattering and for fundamental and nuclear physics research. There also will be extensive facilities for materials irradiation, isotope production, and analytical chemistry. The R&D program will focus on the four objectives: Address feasibility issues; provide analysis support; evaluate options for improvement in performance beyond minimum requirements; and provide prototype demonstrations for unique facilities. The remainder of this report presents (1) the process by which the R&D activities are controlled and (2) a discussion of the individual tasks that have been identified for the R&D program, including their justification, schedule and costs. The activities discussed in this report will be performed by Martin Marietta Energy Systems, Inc. (MMES) through the Oak Ridge National Laboratory (ORNL) and through subcontracts with industry, universities, and other national laboratories. It should be noted that in general a success path has been assumed for all tasks.

  18. Advancing cancer control research in an emerging news media environment.

    PubMed

    Smith, Katherine C; Niederdeppe, Jeff; Blake, Kelly D; Cappella, Joseph N

    2013-12-01

    Cancer is both highly feared and highly newsworthy, and there is a robust body of research documenting the content and effects of cancer news coverage on health behaviors and policy. Recent years have witnessed ongoing, transformative shifts in American journalism alongside rapid advances in communication technology and the public information environment. These changes create a pressing need to consider a new set of research questions, sampling strategies, measurement techniques, and theories of media effects to ensure continued relevance and adaptation of communication research to address critical cancer control concerns. This paper begins by briefly reviewing what we know about the role of cancer news in shaping cancer-related beliefs, attitudes, behaviors, and policies. We then outline challenges and opportunities, both theoretical and methodological, posed by the rapidly changing news media environment and the nature of audience engagement. We organize our discussion around three major shifts associated with the emerging news media environment as it relates to health communication: 1) speed and dynamism of news diffusion, 2) increased narrowcasting of media content for specialized audiences, and 3) broadened participation in shaping media content. In so doing, we articulate a set of questions for future theory and research, in an effort to catalyze innovative communication scholarship to improve cancer prevention and control.

  19. Advanced parallel programming models research and development opportunities.

    SciTech Connect

    Wen, Zhaofang.; Brightwell, Ronald Brian

    2004-07-01

    There is currently a large research and development effort within the high-performance computing community on advanced parallel programming models. This research can potentially have an impact on parallel applications, system software, and computing architectures in the next several years. Given Sandia's expertise and unique perspective in these areas, particularly on very large-scale systems, there are many areas in which Sandia can contribute to this effort. This technical report provides a survey of past and present parallel programming model research projects and provides a detailed description of the Partitioned Global Address Space (PGAS) programming model. The PGAS model may offer several improvements over the traditional distributed memory message passing model, which is the dominant model currently being used at Sandia. This technical report discusses these potential benefits and outlines specific areas where Sandia's expertise could contribute to current research activities. In particular, we describe several projects in the areas of high-performance networking, operating systems and parallel runtime systems, compilers, application development, and performance evaluation.

  20. PREFACE: 6th EEIGM International Conference on Advanced Materials Research

    NASA Astrophysics Data System (ADS)

    Horwat, David; Ayadi, Zoubir; Jamart, Brigitte

    2012-02-01

    The 6th EEIGM Conference on Advanced Materials Research (AMR 2011) was held at the European School of Materials Engineering (EEIGM) on the 7-8 November 2011 in Nancy, France. This biennial conference organized by the EEIGM is a wonderful opportunity for all scientists involved in the EEIGM programme, in the 'Erasmus Mundus' Advanced Materials Science and Engineering Master programme (AMASE) and the 'Erasmus Mundus' Doctoral Programme in Materials Science and Engineering (DocMASE), to present their research in the various fields of Materials Science and Engineering. This conference is also open to other universities who have strong links with the EEIGM and provides a forum for the exchange of ideas, co-operation and future orientations by means of regular presentations, posters and a round-table discussion. This edition of the conference included a round-table discussion on composite materials within the Interreg IVA project '+Composite'. Following the publication of the proceedings of AMR 2009 in Volume 5 of this journal, it is with great pleasure that we present this selection of articles to the readers of IOP Conference Series: Materials Science and Engineering. Once again it represents the interdisciplinary nature of Materials Science and Engineering, covering basic and applicative research on organic and composite materials, metallic materials and ceramics, and characterization methods. The editors are indebted to all the reviewers for reviewing the papers at very short notice. Special thanks are offered to the sponsors of the conference including EEIGM-Université de Lorraine, AMASE, DocMASE, Grand Nancy, Ville de Nancy, Region Lorraine, Fédération Jacques Villermaux, Conseil Général de Meurthe et Moselle, Casden and '+Composite'. Zoubir Ayadi, David Horwat and Brigitte Jamart

  1. The benefits of basic research: advances in reproductive physiology.

    PubMed

    1995-06-01

    At the Population Council's Center for Biomedical Research basic research is being conducted on the reproductive system with a view to develop new contraceptive and reproductive health technologies. Research in the Reproductive Physiology Program at the Center is carried out by reproductive endocrinologists, molecular biologists, and biochemists working in eight laboratories. In several of the laboratories the function of hormones that regulate spermatogenesis is studied. Scientists in Milan Bagchi's laboratory have developed a model system, composed of cellular components in a test tube, that allows them to study the full sequence of events involved in signal transduction. In James Catterall's laboratory, scientists study how androgens regulate sexual development at the molecular level. The steroid hormones cortisol and corticosterone play critical roles in mammalian fetal development. Scientists in several laboratories study the function of two specialized testicular cells: the Leydig and Sertoli cells. The Leydig cell synthesizes and secretes testosterone, an androgen that regulates spermatogenesis. The Sertoli cell maintains the environment in which spermatogenesis occurs. Researchers in Glen Gunsalus's laboratory study an androgen-binding protein secreted by the Sertoli cell. In collaboration with scientists at the Shanghai Research Center of Biotechnology, they used advanced genetic techniques to create a biologically active form of the protein in silk worm larvae. Scientists in Patricia Morris's laboratory recently identified molecular signals that control the interactions between developing sperm and Sertoli and Leydig cells. In the laboratory of David Phillips, scientists are investigating how the HIV virus penetrates the outer layer of cells in the genital tract and infects underlying cells. In 1994 a vaginally applied microbicide was developed that may inhibit infection by sexually transmitted diseases including HIV. Applications of basic research such

  2. Method and apparatus for controlling a powertrain system including a multi-mode transmission

    DOEpatents

    Hessell, Steven M.; Morris, Robert L.; McGrogan, Sean W.; Heap, Anthony H.; Mendoza, Gil J.

    2015-09-08

    A powertrain including an engine and torque machines is configured to transfer torque through a multi-mode transmission to an output member. A method for controlling the powertrain includes employing a closed-loop speed control system to control torque commands for the torque machines in response to a desired input speed. Upon approaching a power limit of a power storage device transferring power to the torque machines, power limited torque commands are determined for the torque machines in response to the power limit and the closed-loop speed control system is employed to determine an engine torque command in response to the desired input speed and the power limited torque commands for the torque machines.

  3. Comprehensive thermal modeling of a power-split hybrid powertrain using battery cell model

    NASA Astrophysics Data System (ADS)

    Mayyas, Abdel Raouf; Omar, Mohammed; Pisu, Pierluigi; Al-Ahmer, Ali; Mayyas, Ahmad; Montes, Carlos; Dongri, Shan

    2011-08-01

    This manuscript discusses the development of a 3D thermal model for a power-split hybrid powertrain, including its battery modules and power electronics. The 3D model utilizes a finite differencing (FD) heat transfer algorithm, complemented with experimental boundary conditions. The experimental setup is configured to acquire the battery current, voltage, and its inner and surface temperatures in discrete and in full-field scans. The power-split hybrid configuration is tested using a standard and artificial driving cycles. A battery resistance model is then used to couple the experimental boundary conditions with the finite differencing code, which employed a cell-based internal heat generation model to describe the pack chemical reaction mechanism. This study presents a complete analysis based on battery current and voltage in relation to vehicle speed. The proposed model also predicts the powertrain spatial and temporal temperature profiles in agreement with the vehicle actual conditions as indicated by the On-Board Diagnosis (OBD) module.

  4. An Evaluation of Relative Damage to the Powertrain System in Tracked Vehicles

    PubMed Central

    Lee, Sang-Ho; Lee, Jeong-Hwan; Goo, Sang-Hwa; Cho, Yong-Cheol; Cho, Ho-Young

    2009-01-01

    The objective of this study was to improve the reliability of the endurance test for the powertrain system of military tracked vehicles. The measurement system that measures the driving duty applied to the powertrain system caused by mobility on roads consists of eight analog channels and two pulse channels, including the propeller shaft output torques for the left and right sides. The data obtained from this measurement system can be used to introduce a new technology that produces the output torque of a torque converter and that can be applied to analyze the revolution counting for the endurance and road mobility in the front unit and represent the relative fatigue damages analysis technique and its results according to the driven roads through a cumulative fatigue method. PMID:22573990

  5. Feasibility of a Single Common Powertrain Lubricant-Transmission Bench Testing

    DTIC Science & Technology

    2015-04-01

    the slate of engine oils tested. 15. SUBJECT TERMS Single Common Powertrain Lubricant, SCPL, Transmission, Caterpillar TO-4, Cat TO-4, Dexron...ix ACRONYMS AND ABBREVIATIONS CAT – Caterpillar FRRET – friction retention kPa – kilopascals m/s – meters per second N-m – Newton Meters...on each oil:  Caterpillar TO-4 Friction Test o TO-4 SEQ 1219 (Elastomeric) o TO-4 SEQ 1221 (Steering Brake Paper) o TO-4 SEQ 1222 (Wheel Brake

  6. Advanced Stirling Convertor Testing at NASA Glenn Research Center

    NASA Technical Reports Server (NTRS)

    Oriti, Salvatore M.; Blaze, Gina M.

    2007-01-01

    The U.S. Department of Energy (DOE), Lockheed Martin Space Systems (LMSS), Sunpower Inc., and NASA Glenn Research Center (GRC) have been developing an Advanced Stirling Radioisotope Generator (ASRG) for use as a power system on space science and exploration missions. This generator will make use of the free-piston Stirling convertors to achieve higher conversion efficiency than currently available alternatives. The ASRG will utilize two Advanced Stirling Convertors (ASC) to convert thermal energy from a radioisotope heat source to electricity. NASA GRC has initiated several experiments to demonstrate the functionality of the ASC, including: in-air extended operation, thermal vacuum extended operation, and ASRG simulation for mobile applications. The in-air and thermal vacuum test articles are intended to provide convertor performance data over an extended operating time. These test articles mimic some features of the ASRG without the requirement of low system mass. Operation in thermal vacuum adds the element of simulating deep space. This test article is being used to gather convertor performance and thermal data in a relevant environment. The ASRG simulator was designed to incorporate a minimum amount of support equipment, allowing integration onto devices powered directly by the convertors, such as a rover. This paper discusses the design, fabrication, and implementation of these experiments.

  7. Advances in targeted proteomics and applications to biomedical research

    PubMed Central

    Shi, Tujin; Song, Ehwang; Nie, Song; Rodland, Karin D.; Liu, Tao; Qian, Wei-Jun; Smith, Richard D.

    2016-01-01

    Targeted proteomics technique has emerged as a powerful protein quantification tool in systems biology, biomedical research, and increasing for clinical applications. The most widely used targeted proteomics approach, selected reaction monitoring (SRM), also known as multiple reaction monitoring (MRM), can be used for quantification of cellular signaling networks and preclinical verification of candidate protein biomarkers. As an extension to our previous review on advances in SRM sensitivity herein we review recent advances in the method and technology for further enhancing SRM sensitivity (from 2012 to present), and highlighting its broad biomedical applications in human bodily fluids, tissue and cell lines. Furthermore, we also review two recently introduced targeted proteomics approaches, parallel reaction monitoring (PRM) and data-independent acquisition (DIA) with targeted data extraction on fast scanning high-resolution accurate-mass (HR/AM) instruments. Such HR/AM targeted quantification with monitoring all target product ions addresses SRM limitations effectively in specificity and multiplexing; whereas when compared to SRM, PRM and DIA are still in the infancy with a limited number of applications. Thus, for HR/AM targeted quantification we focus our discussion on method development, data processing and analysis, and its advantages and limitations in targeted proteomics. Finally, general perspectives on the potential of achieving both high sensitivity and high sample throughput for large-scale quantification of hundreds of target proteins are discussed. PMID:27302376

  8. Recent Advances in Research on Widow Spider Venoms and Toxins

    PubMed Central

    Yan, Shuai; Wang, Xianchun

    2015-01-01

    Widow spiders have received much attention due to the frequently reported human and animal injures caused by them. Elucidation of the molecular composition and action mechanism of the venoms and toxins has vast implications in the treatment of latrodectism and in the neurobiology and pharmaceutical research. In recent years, the studies of the widow spider venoms and the venom toxins, particularly the α-latrotoxin, have achieved many new advances; however, the mechanism of action of the venom toxins has not been completely clear. The widow spider is different from many other venomous animals in that it has toxic components not only in the venom glands but also in other parts of the adult spider body, newborn spiderlings, and even the eggs. More recently, the molecular basis for the toxicity outside the venom glands has been systematically investigated, with four proteinaceous toxic components being purified and preliminarily characterized, which has expanded our understanding of the widow spider toxins. This review presents a glance at the recent advances in the study on the venoms and toxins from the Latrodectus species. PMID:26633495

  9. Major clinical research advances in gynecologic cancer in 2014.

    PubMed

    Suh, Dong Hoon; Lee, Kyung Hun; Kim, Kidong; Kang, Sokbom; Kim, Jae Weon

    2015-04-01

    In 2014, 9 topics were selected as major advances in clinical research for gynecologic oncology: 2 each in cervical and corpus cancer, 4 in ovarian cancer, and 1 in breast cancer. For cervical cancer, several therapeutic agents showed viable antitumor clinical response in recurrent and metastatic disease: bevacizumab, cediranib, and immunotherapies including human papillomavirus (HPV)-tumor infiltrating lymphocytes and Z-100. The HPV test received FDA approval as the primary screening tool of cervical cancer in women aged 25 and older, based on the results of the ATHENA trial, which suggested that the HPV test was a more sensitive and efficient strategy for cervical cancer screening than methods based solely on cytology. For corpus cancers, results of a phase III Gynecologic Oncology Group (GOG) 249 study of early-stage endometrial cancer with high-intermediate risk factors are followed by the controversial topic of uterine power morcellation in minimally invasive gynecologic surgery. Promising results of phase II studies regarding the effectiveness of olaparib in various ovarian cancer settings are summarized. After a brief review of results from a phase III study on pazopanib maintenance therapy in advanced ovarian cancer, 2 outstanding 2014 ASCO presentations cover the topic of using molecular subtypes in predicting response to bevacizumab. A review of the use of opportunistic bilateral salpingectomy as an ovarian cancer preventive strategy in the general population is presented. Two remarkable studies that discussed the effectiveness of adjuvant ovarian suppression in premenopausal early breast cancer have been selected as the last topics covered in this review.

  10. Advances in targeted proteomics and applications to biomedical research

    SciTech Connect

    Shi, Tujin; Song, Ehwang; Nie, Song; Rodland, Karin D.; Liu, Tao; Qian, Wei-Jun; Smith, Richard D.

    2016-08-01

    Targeted proteomics technique has emerged as a powerful protein quantification tool in systems biology, biomedical research, and increasing for clinical applications. The most widely used targeted proteomics approach, selected reaction monitoring (SRM), also known as multiple reaction monitoring (MRM), can be used for quantification of cellular signaling networks and preclinical verification of candidate protein biomarkers. As an extension to our previous review on advances in SRM sensitivity (Shi et al., Proteomics, 12, 1074–1092, 2012) herein we review recent advances in the method and technology for further enhancing SRM sensitivity (from 2012 to present), and highlighting its broad biomedical applications in human bodily fluids, tissue and cell lines. Furthermore, we also review two recently introduced targeted proteomics approaches, parallel reaction monitoring (PRM) and data-independent acquisition (DIA) with targeted data extraction on fast scanning high-resolution accurate-mass (HR/AM) instruments. Such HR/AM targeted quantification with monitoring all target product ions addresses SRM limitations effectively in specificity and multiplexing; whereas when compared to SRM, PRM and DIA are still in the infancy with a limited number of applications. Thus, for HR/AM targeted quantification we focus our discussion on method development, data processing and analysis, and its advantages and limitations in targeted proteomics. Finally, general perspectives on the potential of achieving both high sensitivity and high sample throughput for large-scale quantification of hundreds of target proteins are discussed.

  11. High speed research system study. Advanced flight deck configuration effects

    NASA Technical Reports Server (NTRS)

    Swink, Jay R.; Goins, Richard T.

    1992-01-01

    In mid-1991 NASA contracted with industry to study the high-speed civil transport (HSCT) flight deck challenges and assess the benefits, prior to initiating their High Speed Research Program (HSRP) Phase 2 efforts, then scheduled for FY-93. The results of this nine-month effort are presented, and a number of the most significant findings for the specified advanced concepts are highlighted: (1) a no nose-droop configuration; (2) a far forward cockpit location; and (3) advanced crew monitoring and control of complex systems. The results indicate that the no nose-droop configuration is critically dependent upon the design and development of a safe, reliable, and certifiable Synthetic Vision System (SVS). The droop-nose configuration would cause significant weight, performance, and cost penalties. The far forward cockpit location, with the conventional side-by-side seating provides little economic advantage; however, a configuration with a tandem seating arrangement provides a substantial increase in either additional payload (i.e., passengers) or potential downsizing of the vehicle with resulting increases in performance efficiencies and associated reductions in emissions. Without a droop nose, forward external visibility is negated and takeoff/landing guidance and control must rely on the use of the SVS. The technologies enabling such capabilities, which de facto provides for Category 3 all-weather operations on every flight independent of weather, represent a dramatic benefits multiplier in a 2005 global ATM network: both in terms of enhanced economic viability and environmental acceptability.

  12. The biology of infertility: research advances and clinical challenges

    PubMed Central

    Matzuk, Martin M; Lamb, Dolores J

    2013-01-01

    Reproduction is required for the survival of all mammalian species, and thousands of essential ‘sex’ genes are conserved through evolution. Basic research helps to define these genes and the mechanisms responsible for the development, function and regulation of the male and female reproductive systems. However, many infertile couples continue to be labeled with the diagnosis of idiopathic infertility or given descriptive diagnoses that do not provide a cause for their defect. For other individuals with a known etiology, effective cures are lacking, although their infertility is often bypassed with assisted reproductive technologies (ART), some accompanied by safety or ethical concerns. Certainly, progress in the field of reproduction has been realized in the twenty-first century with advances in the understanding of the regulation of fertility, with the production of over 400 mutant mouse models with a reproductive phenotype and with the promise of regenerative gonadal stem cells. Indeed, the past six years have witnessed a virtual explosion in the identification of gene mutations or polymorphisms that cause or are linked to human infertility. Translation of these findings to the clinic remains slow, however, as do new methods to diagnose and treat infertile couples. Additionally, new approaches to contraception remain elusive. Nevertheless, the basic and clinical advances in the understanding of the molecular controls of reproduction are impressive and will ultimately improve patient care. PMID:18989307

  13. XII Advanced Computing and Analysis Techniques in Physics Research

    NASA Astrophysics Data System (ADS)

    Speer, Thomas; Carminati, Federico; Werlen, Monique

    November 2008 will be a few months after the official start of LHC when the highest quantum energy ever produced by mankind will be observed by the most complex piece of scientific equipment ever built. LHC will open a new era in physics research and push further the frontier of Knowledge This achievement has been made possible by new technological developments in many fields, but computing is certainly the technology that has made possible this whole enterprise. Accelerator and detector design, construction management, data acquisition, detectors monitoring, data analysis, event simulation and theoretical interpretation are all computing based HEP activities but also occurring many other research fields. Computing is everywhere and forms the common link between all involved scientists and engineers. The ACAT workshop series, created back in 1990 as AIHENP (Artificial Intelligence in High Energy and Nuclear Research) has been covering the tremendous evolution of computing in its most advanced topics, trying to setup bridges between computer science, experimental and theoretical physics. Conference web-site: http://acat2008.cern.ch/ Programme and presentations: http://indico.cern.ch/conferenceDisplay.py?confId=34666

  14. The neutron texture diffractometer at the China Advanced Research Reactor

    NASA Astrophysics Data System (ADS)

    Li, Mei-Juan; Liu, Xiao-Long; Liu, Yun-Tao; Tian, Geng-Fang; Gao, Jian-Bo; Yu, Zhou-Xiang; Li, Yu-Qing; Wu, Li-Qi; Yang, Lin-Feng; Sun, Kai; Wang, Hong-Li; Santisteban, J. r.; Chen, Dong-Feng

    2016-03-01

    The first neutron texture diffractometer in China has been built at the China Advanced Research Reactor, due to strong demand for texture measurement with neutrons from the domestic user community. This neutron texture diffractometer has high neutron intensity, moderate resolution and is mainly applied to study texture in commonly used industrial materials and engineering components. In this paper, the design and characteristics of this instrument are described. The results for calibration with neutrons and quantitative texture analysis of zirconium alloy plate are presented. The comparison of texture measurements with the results obtained in HIPPO at LANSCE and Kowari at ANSTO illustrates the reliability of the texture diffractometer. Supported by National Nature Science Foundation of China (11105231, 11205248, 51327902) and International Atomic Energy Agency-TC program (CPR0012)

  15. Advanced research on anti-tumor effects of amygdalin.

    PubMed

    Song, Zuoqing; Xu, Xiaohong

    2014-08-01

    Malignant tumors are the major disease that cause serious damage to human health, and have been listed as the premier diseases which seriously threatened human health by World Health Organization (WHO). In recent years the development of antitumor drugs has been gradually transformed from cytotoxic drugs to improving the selectivity of drugs, overcoming multidrug resistance, development of new targeted drugs and low toxicity with high specificity drugs. Amygdalin is a natural product that owns antitumor activity, less side effects, widely sourced and relatively low priced. All these features make the amygdalin a promising antitumor drugs, if combined with conditional chemotherapy drugs, which can produce synergistic effect. In this paper, we summarized the pharmacological activity, toxicity and antitumor activity of amygdalin, mainly focused on the advanced research of amygdalin on its antitumor effects in recent years, providing new insights for the development of new anticancer drugs, new targets searching and natural antitumor mechanism investigations.

  16. Research opportunities in atomic physics at the Advanced Light Source

    NASA Astrophysics Data System (ADS)

    Schlachter, A. S.; Robinson, A. L.

    1989-09-01

    The Advanced Light Source (ALS) now under construction at the Lawrence Berkeley Laboratory is being planned as a national user facility for the production of high-brightness and partially coherent X-ray and ultraviolet synchrotron radiation. The ALS is based on a low-emittance electron storage ring optimized for operation at 1.5 GeV with insertion devices in 11 long straight sections and up to 48 bending-magnet ports. High-brightness photon beams from less than 10 eV to more than 1 keV will be produced by undulators, thereby providing many research opportunities in atomic and molecular physics and chemistry. Wigglers and bending magnets will provide high-flux broad-band radiation at energies to 10 keV.

  17. Review on advances in nanoscale microscopy in cement research.

    PubMed

    Sharif, Ahmed

    2016-01-01

    With the rapid advancement of nanotechnology, manipulation and characterization of materials in nano scale have become an obvious part of construction related technology. This review will focus on some of the nanoscopy techniques that are most frequently used in current research of cement based nanostructured materials. In particular scanning electron microscopy, transmission electron microscopy, atomic force microscopy, scanning tunneling microscopy, tomography, scanning transmission X-ray microscopy and laser scanning confocal microscopy are addressed. A number of case studies related to microscopic characterization of nano materials utilizing the aforementioned techniques from the published literature are discussed. While these approaches are beginning to yield promising insight, continued progress will definitely provide a potential sustainable solution for the design, development and promotion towards nanoscale engineering of cementitious materials.

  18. Lipids from heterotrophic microbes: advances in metabolism research.

    PubMed

    Kosa, Matyas; Ragauskas, Arthur J

    2011-02-01

    Heterotrophic oleaginous microorganisms are capable of producing over 20% of their weight in single cell oils (SCOs) composed of triacylglycerols (TAGs). These TAGs contain fatty acids, such as palmitic, stearic and oleic acids, that are well-suited for biodiesel applications. Although some of these microbes are able to accumulate SCOs while growing on inexpensive agro-industrial biomass, the competition with plant oil resources means that a significant increase in productivity is desired. The present review aims to summarize recent details in lipid metabolism research and engineering (e.g. direct fatty acid ethyl ester production), as well as culture condition optimization and innovations, such as solid-state or semi-solid-state fermentation, that can all contribute to higher productivity and further advancement of the field.

  19. [Recent advances of genetic research on paroxysmal kinesigenic dyskinesias].

    PubMed

    Li, Xun-hua; Chen, Su-qin; Wang, Yi-ming

    2008-08-01

    Paroxysmal kinesigenic choreoathetosis/dyskinesias (PKC/PKD) is one of the most common types of praoxysmal dyskinesia. It is characterized by recurrent episodic dystonia and/or choreoathetotic attacks triggered by sudden voluntary movement. Some patients have a history of febrile infantile convulsion. PKD commonly occurs sporadically or as an autosomal-dominant familial trait with variable penetrance. It has been linked to 16p12-q12 or 16q13-q22 loci in various families of different populations, which suggests a genetic heterogeneity. The exact etiology and pathogenesis of PKD await further elucidation, although ion channelopathy is suggested as a probable underlying etiology. Here, the recent advances of the genetic research on PKD will be reviewed.

  20. [Advances in the researches of lutein and alzheimer's disease].

    PubMed

    Xu, Xianrong; Lin, Xiaoming

    2015-05-01

    Lutein, a kind of oxycarotenoid, can pass the blood brain barrier and preferentially accumulate in the human brain, which is the most abundant carotenoid in human brain. Evidence from multiple studies suggested that lutein was closely related to age-related cognitive decline and risk of Alzheimer's disease (AD) in human. Dietary, plasma and brain concentrations of lutein were negatively associated with age-related cognitive decline. Lutein concentrations in plasma and brain were significantly lower in AD patients than those of health control. In human brain, lutein was the sole carotenoid which consistently associated with a range of cognitive function measures. In elderly women, lutein supplement can improve the cognitive function. In this article, we systematically reviewed the literature on the role of lutein in age-related cognitive decline and alzheimer's disease and its possible mechanisms. It may prove some benefit information for the advanced research and prevention of AD.

  1. [Research advances in soil fungal diversity and molecular ecology].

    PubMed

    Zhang, Jing; Zhang, Huiwen; Li, Xinyu; Zhang, Chenggang

    2004-10-01

    Fungi are a kind of important soil microorganisms that participate in the decomposition of organic materials and supply nutrients to the plant through symbiosis. But, they can also reduce the output of food due to the existence of pathogenic fungi. Soil fungal diversity plays a fundamentally unique role in maintaining the balance of ecosystem and in supplying large amount of undeveloped resources for the people. In this paper, soil fungal diversity was expatiated from the viewpoints of species diversity, habitant diversity and functional diversity, and furthermore, the research advances in the molecular ecology of soil fungal diversity were reviewed from the aspects of the fungal diversity of farmland, woodland, pasture, extreme environment, and other complex environments. The affecting factors of soil fungal diversity were discussed, and the development trend of the study on soil fungal diversity was also approached.

  2. Advanced research and technology programs for advanced high-pressure oxygen-hydrogen rocket propulsion

    NASA Astrophysics Data System (ADS)

    Marsik, S. J.; Morea, S. F.

    1985-03-01

    A research and technology program for advanced high pressure, oxygen-hydrogen rocket propulsion technology is presently being pursued by the National Aeronautics and Space Administration (NASA) to establish the basic discipline technologies, develop the analytical tools, and establish the data base necessary for an orderly evolution of the staged combustion reusable rocket engine. The need for the program is based on the premise that the USA will depend on the Shuttle and its derivative versions as its principal Earth-to-orbit transportation system for the next 20 to 30 yr. The program is focused in three principal areas of enhancement: (1) life extension, (2) performance, and (3) operations and diagnosis. Within the technological disciplines the efforts include: rotordynamics, structural dynamics, fluid and gas dynamics, materials fatigue/fracture/life, turbomachinery fluid mechanics, ignition/combustion processes, manufacturing/producibility/nondestructive evaluation methods and materials development/evaluation. An overview of the Advanced High Pressure Oxygen-Hydrogen Rocket Propulsion Technology Program Structure and Working Groups objectives are presented with highlights of several significant achievements.

  3. Advanced research and technology program for advanced high pressure oxygen-hydrogen rocket propulsion

    NASA Technical Reports Server (NTRS)

    Marsik, S. J.; Morea, S. F.

    1985-01-01

    A research and technology program for advanced high pressure, oxygen-hydrogen rocket propulsion technology is presently being pursued by the National Aeronautics and Space Administration (NASA) to establish the basic discipline technologies, develop the analytical tools, and establish the data base necessary for an orderly evolution of the staged combustion reusable rocket engine. The need for the program is based on the premise that the USA will depend on the Shuttle and its derivative versions as its principal Earth-to-orbit transportation system for the next 20 to 30 yr. The program is focused in three principal areas of enhancement: (1) life extension, (2) performance, and (3) operations and diagnosis. Within the technological disciplines the efforts include: rotordynamics, structural dynamics, fluid and gas dynamics, materials fatigue/fracture/life, turbomachinery fluid mechanics, ignition/combustion processes, manufacturing/producibility/nondestructive evaluation methods and materials development/evaluation. An overview of the Advanced High Pressure Oxygen-Hydrogen Rocket Propulsion Technology Program Structure and Working Groups objectives are presented with highlights of several significant achievements.

  4. Advanced research and technology programs for advanced high-pressure oxygen-hydrogen rocket propulsion

    NASA Technical Reports Server (NTRS)

    Marsik, S. J.; Morea, S. F.

    1985-01-01

    A research and technology program for advanced high pressure, oxygen-hydrogen rocket propulsion technology is presently being pursued by the National Aeronautics and Space Administration (NASA) to establish the basic discipline technologies, develop the analytical tools, and establish the data base necessary for an orderly evolution of the staged combustion reusable rocket engine. The need for the program is based on the premise that the USA will depend on the Shuttle and its derivative versions as its principal Earth-to-orbit transportation system for the next 20 to 30 yr. The program is focused in three principal areas of enhancement: (1) life extension, (2) performance, and (3) operations and diagnosis. Within the technological disciplines the efforts include: rotordynamics, structural dynamics, fluid and gas dynamics, materials fatigue/fracture/life, turbomachinery fluid mechanics, ignition/combustion processes, manufacturing/producibility/nondestructive evaluation methods and materials development/evaluation. An overview of the Advanced High Pressure Oxygen-Hydrogen Rocket Propulsion Technology Program Structure and Working Groups objectives are presented with highlights of several significant achievements.

  5. Optimum design of a fuel-cell powertrain based on multiple design criteria

    NASA Astrophysics Data System (ADS)

    Sarioglu, Ismail Levent; Czapnik, Bartosch; Bostanci, Emine; Klein, Olaf P.; Schröder, Hendrik; Küçükay, Ferit

    2014-11-01

    As the number of fuel-cell vehicles on the roads increase, the vehicle designs are gaining more importance. Clearly, one major topic in this field is the optimization of powertrain designs. In this design process, the aim of the car manufacturers is to meet the expectations of the potential customer best, while creating a sustainable product. However, due to several trade-offs in the design, it would be non-realistic to expect a single solution that fulfills all design objectives. Therefore, a systematical approach, which includes a trade-off analysis and evaluation methods for this multiobjective design problem, is required. In this paper, a suitable methodology is presented and applied in a case study, where an optimum powertrain design for a typical European long-range passenger car is sought. Simulation-aided powertrain models and scalable component models are used to increase the accuracy of the design process. Furthermore, various visual and quantitative evaluation techniques are applied in order to support the decision making process.

  6. FY09 Advanced Instrumentation and Active Interrogation Research for Safeguards

    SciTech Connect

    D. L. Chichester; S. A. Pozzi; E. H. Seabury; J. L. Dolan; M. Flaska; J. T. Johnson; S. M. Watson; J. Wharton

    2009-08-01

    Multiple small-scale projects have been undertaken to investigate advanced instrumentation solutions for safeguard measurement challenges associated with advanced fuel cycle facilities and next-generation fuel reprocessing installations. These activities are in support of the U.S. Department of Energy's Fuel Cycle Research and Development program and its Materials Protection, Accounting, and Control for Transmutation (MPACT) campaign. 1) Work was performed in a collaboration with the University of Michigan (Prof. Sara Pozzi, co-PI) to investigate the use of liquid-scintillator radiation detectors for assaying mixed-oxide (MOX) fuel, to characterize its composition and to develop advanced digital pulse-shape discrimination algorithms for performing time-correlation measurements in the MOX fuel environment. This work included both simulations and experiments and has shown that these techniques may provide a valuable approach for use within advanced safeguard measurement scenarios. 2) Work was conducted in a collaboration with Oak Ridge National Laboratory (Dr. Paul Hausladen, co-PI) to evaluate the strengths and weaknesses of the fast-neutron coded-aperture imaging technique for locating and characterizing fissile material, and as a tool for performing hold-up measurements in fissile material handling facilities. This work involved experiments at Idaho National Laboratory, using MOX fuel and uranium metal, in both passive and active interrogation configurations. A complete analysis has not yet been completed but preliminary results suggest several potential uses for the fast neutron imaging technique. 3) Work was carried out to identify measurement approaches for determining nitric acid concentration in the range of 1 – 4 M and beyond. This work included laboratory measurements to investigate the suitability of prompt-gamma neutron activation analysis for this measurement and product reviews of other commercial solutions. Ultrasonic density analysis appears to be

  7. Invited Review Article: Advanced light microscopy for biological space research

    NASA Astrophysics Data System (ADS)

    De Vos, Winnok H.; Beghuin, Didier; Schwarz, Christian J.; Jones, David B.; van Loon, Jack J. W. A.; Bereiter-Hahn, Juergen; Stelzer, Ernst H. K.

    2014-10-01

    As commercial space flights have become feasible and long-term extraterrestrial missions are planned, it is imperative that the impact of space travel and the space environment on human physiology be thoroughly characterized. Scrutinizing the effects of potentially detrimental factors such as ionizing radiation and microgravity at the cellular and tissue level demands adequate visualization technology. Advanced light microscopy (ALM) is the leading tool for non-destructive structural and functional investigation of static as well as dynamic biological systems. In recent years, technological developments and advances in photochemistry and genetic engineering have boosted all aspects of resolution, readout and throughput, rendering ALM ideally suited for biological space research. While various microscopy-based studies have addressed cellular response to space-related environmental stressors, biological endpoints have typically been determined only after the mission, leaving an experimental gap that is prone to bias results. An on-board, real-time microscopical monitoring device can bridge this gap. Breadboards and even fully operational microscope setups have been conceived, but they need to be rendered more compact and versatile. Most importantly, they must allow addressing the impact of gravity, or the lack thereof, on physiologically relevant biological systems in space and in ground-based simulations. In order to delineate the essential functionalities for such a system, we have reviewed the pending questions in space science, the relevant biological model systems, and the state-of-the art in ALM. Based on a rigorous trade-off, in which we recognize the relevance of multi-cellular systems and the cellular microenvironment, we propose a compact, but flexible concept for space-related cell biological research that is based on light sheet microscopy.

  8. Invited Review Article: Advanced light microscopy for biological space research

    SciTech Connect

    De Vos, Winnok H.; Beghuin, Didier; Schwarz, Christian J.; Jones, David B.; Loon, Jack J. W. A. van

    2014-10-15

    As commercial space flights have become feasible and long-term extraterrestrial missions are planned, it is imperative that the impact of space travel and the space environment on human physiology be thoroughly characterized. Scrutinizing the effects of potentially detrimental factors such as ionizing radiation and microgravity at the cellular and tissue level demands adequate visualization technology. Advanced light microscopy (ALM) is the leading tool for non-destructive structural and functional investigation of static as well as dynamic biological systems. In recent years, technological developments and advances in photochemistry and genetic engineering have boosted all aspects of resolution, readout and throughput, rendering ALM ideally suited for biological space research. While various microscopy-based studies have addressed cellular response to space-related environmental stressors, biological endpoints have typically been determined only after the mission, leaving an experimental gap that is prone to bias results. An on-board, real-time microscopical monitoring device can bridge this gap. Breadboards and even fully operational microscope setups have been conceived, but they need to be rendered more compact and versatile. Most importantly, they must allow addressing the impact of gravity, or the lack thereof, on physiologically relevant biological systems in space and in ground-based simulations. In order to delineate the essential functionalities for such a system, we have reviewed the pending questions in space science, the relevant biological model systems, and the state-of-the art in ALM. Based on a rigorous trade-off, in which we recognize the relevance of multi-cellular systems and the cellular microenvironment, we propose a compact, but flexible concept for space-related cell biological research that is based on light sheet microscopy.

  9. Invited review article: Advanced light microscopy for biological space research.

    PubMed

    De Vos, Winnok H; Beghuin, Didier; Schwarz, Christian J; Jones, David B; van Loon, Jack J W A; Bereiter-Hahn, Juergen; Stelzer, Ernst H K

    2014-10-01

    As commercial space flights have become feasible and long-term extraterrestrial missions are planned, it is imperative that the impact of space travel and the space environment on human physiology be thoroughly characterized. Scrutinizing the effects of potentially detrimental factors such as ionizing radiation and microgravity at the cellular and tissue level demands adequate visualization technology. Advanced light microscopy (ALM) is the leading tool for non-destructive structural and functional investigation of static as well as dynamic biological systems. In recent years, technological developments and advances in photochemistry and genetic engineering have boosted all aspects of resolution, readout and throughput, rendering ALM ideally suited for biological space research. While various microscopy-based studies have addressed cellular response to space-related environmental stressors, biological endpoints have typically been determined only after the mission, leaving an experimental gap that is prone to bias results. An on-board, real-time microscopical monitoring device can bridge this gap. Breadboards and even fully operational microscope setups have been conceived, but they need to be rendered more compact and versatile. Most importantly, they must allow addressing the impact of gravity, or the lack thereof, on physiologically relevant biological systems in space and in ground-based simulations. In order to delineate the essential functionalities for such a system, we have reviewed the pending questions in space science, the relevant biological model systems, and the state-of-the art in ALM. Based on a rigorous trade-off, in which we recognize the relevance of multi-cellular systems and the cellular microenvironment, we propose a compact, but flexible concept for space-related cell biological research that is based on light sheet microscopy.

  10. Fossil energy: From laboratory to marketplace. Part 2, The role of advanced research

    SciTech Connect

    Not Available

    1992-03-01

    The purpose of this work is to provide a summary description of the role of advanced research in the overall Fossil Energy R&D program successes. It presents the specific Fossil Energy advanced research products that have been adopted commercially or fed into other R&D programs as part of the crosscutting enabling technology base upon which advanced systems are based.

  11. Research investigations in oil shale, tar sand, coal research, advanced exploratory process technology, and advanced fuels research: Volume 1 -- Base program. Final report, October 1986--September 1993

    SciTech Connect

    Smith, V.E.

    1994-05-01

    Numerous studies have been conducted in five principal areas: oil shale, tar sand, underground coal gasification, advanced process technology, and advanced fuels research. In subsequent years, underground coal gasification was broadened to be coal research, under which several research activities were conducted that related to coal processing. The most significant change occurred in 1989 when the agreement was redefined as a Base Program and a Jointly Sponsored Research Program (JSRP). Investigations were conducted under the Base Program to determine the physical and chemical properties of materials suitable for conversion to liquid and gaseous fuels, to test and evaluate processes and innovative concepts for such conversions, to monitor and determine environmental impacts related to development of commercial-sized operations, and to evaluate methods for mitigation of potential environmental impacts. This report is divided into two volumes: Volume 1 consists of 28 summaries that describe the principal research efforts conducted under the Base Program in five topic areas. Volume 2 describes tasks performed within the JSRP. Research conducted under this agreement has resulted in technology transfer of a variety of energy-related research information. A listing of related publications and presentations is given at the end of each research topic summary. More specific and detailed information is provided in the topical reports referenced in the related publications listings.

  12. Fingerprint identification: advances since the 2009 National Research Council report

    PubMed Central

    Champod, Christophe

    2015-01-01

    This paper will discuss the major developments in the area of fingerprint identification that followed the publication of the National Research Council (NRC, of the US National Academies of Sciences) report in 2009 entitled: Strengthening Forensic Science in the United States: A Path Forward. The report portrayed an image of a field of expertise used for decades without the necessary scientific research-based underpinning. The advances since the report and the needs in selected areas of fingerprinting will be detailed. It includes the measurement of the accuracy, reliability, repeatability and reproducibility of the conclusions offered by fingerprint experts. The paper will also pay attention to the development of statistical models allowing assessment of fingerprint comparisons. As a corollary of these developments, the next challenge is to reconcile a traditional practice dominated by deterministic conclusions with the probabilistic logic of any statistical model. There is a call for greater candour and fingerprint experts will need to communicate differently on the strengths and limitations of their findings. Their testimony will have to go beyond the blunt assertion of the uniqueness of fingerprints or the opinion delivered ispe dixit. PMID:26101284

  13. Fingerprint identification: advances since the 2009 National Research Council report.

    PubMed

    Champod, Christophe

    2015-08-05

    This paper will discuss the major developments in the area of fingerprint identification that followed the publication of the National Research Council (NRC, of the US National Academies of Sciences) report in 2009 entitled: Strengthening Forensic Science in the United States: A Path Forward. The report portrayed an image of a field of expertise used for decades without the necessary scientific research-based underpinning. The advances since the report and the needs in selected areas of fingerprinting will be detailed. It includes the measurement of the accuracy, reliability, repeatability and reproducibility of the conclusions offered by fingerprint experts. The paper will also pay attention to the development of statistical models allowing assessment of fingerprint comparisons. As a corollary of these developments, the next challenge is to reconcile a traditional practice dominated by deterministic conclusions with the probabilistic logic of any statistical model. There is a call for greater candour and fingerprint experts will need to communicate differently on the strengths and limitations of their findings. Their testimony will have to go beyond the blunt assertion of the uniqueness of fingerprints or the opinion delivered ispe dixit.

  14. [Research advances in cadmium pollution of peanut (Arachis hypogaea L.)].

    PubMed

    Wang, Kai-rong; Zhang, Lei

    2008-12-01

    Peanut (Arachis hypogaea L.) is a major oil-bearing crop in the world, and as well, an important resource of plant protein and a main raw material for food processing. With the increasing of its direct human consumption and food processing, the Cd concentration in peanut kernel has aroused great concern in recent years. China is a main country of the production and exportation of peanut, but the Cd enrichment in peanut kernel is the main obstacle for its peanut export trade. In this paper, the research advances in Cd pollution of peanut kernel were reviewed, based on the characteristics and mechanisms of Cd accumulation and distribution in peanut kernel, the intra-specific variation of kernel Cd content, and the measures in controlling kernel Cd content. Two strategies were put forward for controlling Cd pollution of peanut kernel, i.e., to reduce the Cd uptake by main root system of peanut plant, and to control the transference of Cd from root to fruit (kernel). In order to applying the strategies effectively, researches on the mechanisms of Cd accumulation in peanut kernel should be enhanced in three aspects, i.e., root vitality and its relationship with Cd accumulation in kernel, mechanism of fruit Cd absorption and its contribution to kernel Cd content, and mechanism of Cd transference in plants and its effects on kernel Cd content.

  15. ARCHES: Advancing Research & Capacity in Hydrologic Education and Science

    NASA Astrophysics Data System (ADS)

    Milewski, A.; Fryar, A. E.; Durham, M. C.; Schroeder, P.; Agouridis, C.; Hanley, C.; Rotz, R. R.

    2013-12-01

    Educating young scientists and building capacity on a global scale is pivotal towards better understanding and managing our water resources. Based on this premise the ARCHES (Advancing Research & Capacity in Hydrologic Education and Science) program has been established. This abstract provides an overview of the program, links to access information, and describes the activities and outcomes of student participants from the Middle East and North Africa. The ARCHES program (http://arches.wrrs.uga.edu) is an integrated hydrologic education approach using online courses, field programs, and various hands-on workshops. The program aims to enable young scientists to effectively perform the high level research that will ultimately improve quality of life, enhance science-based decision making, and facilitate collaboration. Three broad, interlinked sets of activities are incorporated into the ARCHES program: (A1) the development of technical expertise, (A2) the development of professional contacts and skills, and (A3) outreach and long-term sustainability. The development of technical expertise (A1) is implemented through three progressive instructional sections. Section 1: Students were guided through a series of online lectures and exercises (Moodle: http://wrrs.uga.edu/moodle) covering three main topics (Remote Sensing, GIS, and Hydrologic Modeling). Section 2: Students participated in a hands-on workshop hosted at the University of Georgia's Water Resources and Remote Sensing Laboratory (WRRSL). Using ENVI, ArcGIS, and ArcSWAT, students completed a series of lectures and real-world applications (e.g., Development of Hydrologic Models). Section 3: Students participated in field studies (e.g., measurements of infiltration, recharge, streamflow, and water-quality parameters) conducted by U.S. partners and international collaborators in the participating countries. The development of professional contacts and skills (A2) was achieved through the promotion of networking

  16. [Advanced Gas Turbine Systems Research]. Technical Quarterly Progress Report

    SciTech Connect

    1998-09-30

    Major Accomplishments by Advanced Gas Turbine Systems Research (AGTSR) during this reporting period are highlighted below and amplified in later sections of this report: AGTSR distributed 50 proposals from the 98RFP to the IRB for review, evaluation and rank-ordering during the summer; AGTSR conducted a detailed program review at DOE-FETC on July 24; AGTSR organized the 1998 IRB proposal review meeting at SCIES on September 15-16; AGTSR consolidated all the IRB proposal scores and rank-orderings to facilitate the 98RFP proposal deliberations; AGTSR submitted meeting minutes and proposal short-list recommendation to the IRB and DOE for the 98RFP solicitation; AGTSR reviewed two gas turbine related proposals as part of the CU RFP State Project for renovating the central energy facility; AGTSR reviewed and cleared research papers with the IRB from the University of Pittsburgh, Wisconsin, and Minnesota; AGTSR assisted GTA in obtaining university stakeholder support of the ATS program from California, Pennsylvania, and Colorado; AGTSR assisted GTA in distributing alert notices on potential ATS budget cuts to over 150 AGTSR performing university members; AGTSR submitted proceedings booklet and organizational information pertaining to the OAI hybrid gas turbine workshop to DOE-FETC; For DOE-FETC, AGTSR updated the university consortium poster to include new members and research highlights; For DOE-FETC, the general AGTSR Fact Sheet was updated to include new awards, workshops, educational activity and select accomplishments from the research projects; For DOE-FETC, AGTSR prepared three fact sheets highlighting university research supported in combustion, aero-heat transfer, and materials; For DOE-FETC, AGTSR submitted pictures on materials research for inclusion in the ATS technology brochure; For DOE-FETC, AGTSR submitted a post-2000 roadmap showing potential technology paths AGTSR could pursue in the next decade; AGTSR distributed the ninth newsletter UPDATE to DOE, the

  17. Advanced Stirling Convertor Testing at NASA Glenn Research Center

    NASA Technical Reports Server (NTRS)

    Wilson, Scott D.; Poriti, Sal

    2010-01-01

    The NASA Glenn Research Center (GRC) has been testing high-efficiency free-piston Stirling convertors for potential use in radioisotope power systems (RPSs) since 1999. The current effort is in support of the Advanced Stirling Radioisotope Generator (ASRG), which is being developed by the U.S. Department of Energy (DOE), Lockheed Martin Space Systems Company (LMSSC), Sunpower, Inc., and the NASA GRC. This generator would use two high-efficiency Advanced Stirling Convertors (ASCs) to convert thermal energy from a radioisotope heat source into electricity. As reliability is paramount to a RPS capable of providing spacecraft power for potential multi-year missions, GRC provides direct technology support to the ASRG flight project in the areas of reliability, convertor and generator testing, high-temperature materials, structures, modeling and analysis, organics, structural dynamics, electromagnetic interference (EMI), and permanent magnets to reduce risk and enhance reliability of the convertor as this technology transitions toward flight status. Convertor and generator testing is carried out in short- and long-duration tests designed to characterize convertor performance when subjected to environments intended to simulate launch and space conditions. Long duration testing is intended to baseline performance and observe any performance degradation over the life of the test. Testing involves developing support hardware that enables 24/7 unattended operation and data collection. GRC currently has 14 Stirling convertors under unattended extended operation testing, including two operating in the ASRG Engineering Unit (ASRG-EU). Test data and high-temperature support hardware are discussed for ongoing and future ASC tests with emphasis on the ASC-E and ASC-E2.

  18. Fuel cell and lithium iron phosphate battery hybrid powertrain with an ultracapacitor bank using direct parallel structure

    NASA Astrophysics Data System (ADS)

    Xie, Changjun; Xu, Xinyi; Bujlo, Piotr; Shen, Di; Zhao, Hengbing; Quan, Shuhai

    2015-04-01

    In this study, a novel fuel cell-Li-ion battery hybrid powertrain using a direct parallel structure with an ultracapacitor bank is presented. In addition, a fuzzy logic controller is designed for the energy management of hybrid powertrain aimed at adjusting and stabilizing the DC bus voltage via a bidirectional DC/DC converter. To validate the Fuel cell-Li-ion battery-Ultracapacitor (FC-LIB-UC) hybrid powertrain and energy management strategies developed in this study, a test station powered by a 1 kW fuel cell system, a 2.8 kWh Li-ion battery pack and a 330 F/48.6 V ultracapacitor bank is designed and constructed on the basis of stand-alone module. Finally, an Urban Dynamometer Driving Schedule cycle is performed on this station and the experimental results show that: (i) the power distribution of FC system is narrowest and the power distribution of UC bank is widest during a cycle, and (ii) the FC system is controlled to satisfy the slow dynamic variation in this hybrid powertrain and the output of the LIB pack and UC bank is adjusted to meet fast dynamic load requirements. As a result, the proposed FC-LIB-UC hybrid powertrain can take full advantage of three kinds of energy sources.

  19. Powertrain Component Inspection from Mid-Level Blends Vehicle Aging Study

    SciTech Connect

    Shoffner, Brent; Johnson, Ryan; Heimrich, Martin J.; Lochte, Michael

    2010-11-01

    The Energy Independence and Security Act of 2007 calls on the nation to significantly increase its use of renewable fuels to meet its transportation energy needs. The law expands the renewable fuel standard to require use of 36 billion gallons of renewable fuel by 2022. Given that ethanol is the most widely used renewable fuel in the U.S. market, ethanol will likely make up a significant portion of the 36-billion-gallon requirement. The vast majority of ethanol used in the United States is blended with gasoline to create E10-gasoline with up to 10% ethanol. The remaining ethanol is sold in the form of E85 - a gasoline blend with as much as 85% ethanol that can only be used in flexible-fuel vehicles (FFVs). Consumption of E85 is at present limited by both the size of the FFV fleet and the number of E85 fueling stations. Gasoline consumption in the United States is currently about 140 billion gallons per year; thus the maximum use of ethanol as E10 is only about 14 billion gallons. While the U.S. Department of Energy (DOE) remains committed to expanding the E85 infrastructure, that market represented less than 1% of the ethanol consumed in 2010 and will not be able to absorb projected volumes of ethanol in the near term. Because of these factors, DOE and others have been assessing the viability of using mid-level ethanol blends (E15 or E20) as a way to accommodate growing volumes of ethanol. The DOE Mid-Level Ethanol Blends Test Program has been under way since 2007, supported jointly by the Office of the Biomass Program and the Vehicle Technologies Program. One of the larger projects, the Catalyst Durability Study, or Vehicle Aging Study, will be completed early in calendar year 2011. The following report describes a subproject of the Vehicle Aging Study in which powertrain components from 18 of the vehicles were examined at Southwest Research Institute under contract to Oak Ridge National Laboratory (ORNL).

  20. Oil shale, tar sand, coal research, advanced exploratory process technology, jointly sponsored research

    SciTech Connect

    Not Available

    1992-01-01

    Progress made in five research programs is described. The subtasks in oil shale study include oil shale process studies and unconventional applications and markets for western oil shale.The tar sand study is on recycle oil pyrolysis and extraction (ROPE) process. Four tasks are described in coal research: underground coal gasification; coal combustion; integrated coal processing concepts; and sold waste management. Advanced exploratory process technology includes: advanced process concepts; advanced mitigation concepts; and oil and gas technology. Jointly sponsored research covers: organic and inorganic hazardous waste stabilization; CROW field demonstration with Bell Lumber and Pole; development and validation of a standard test method for sequential batch extraction fluid; PGI demonstration project; operation and evaluation of the CO[sub 2] HUFF-N-PUFF process; fly ash binder for unsurfaced road aggregates; solid state NMR analysis of Mesaverde group, Greater Green River Basin, tight gas sands; flow-loop testing of double-wall pipe for thermal applications; shallow oil production using horizontal wells with enhanced oil recovery techniques; NMR analysis of sample from the ocean drilling program; and menu driven access to the WDEQ hydrologic data management system.

  1. Advanced quantitative measurement methodology in physics education research

    NASA Astrophysics Data System (ADS)

    Wang, Jing

    The ultimate goal of physics education research (PER) is to develop a theoretical framework to understand and improve the learning process. In this journey of discovery, assessment serves as our headlamp and alpenstock. It sometimes detects signals in student mental structures, and sometimes presents the difference between expert understanding and novice understanding. Quantitative assessment is an important area in PER. Developing research-based effective assessment instruments and making meaningful inferences based on these instruments have always been important goals of the PER community. Quantitative studies are often conducted to provide bases for test development and result interpretation. Statistics are frequently used in quantitative studies. The selection of statistical methods and interpretation of the results obtained by these methods shall be connected to the education background. In this connecting process, the issues of educational models are often raised. Many widely used statistical methods do not make assumptions on the mental structure of subjects, nor do they provide explanations tailored to the educational audience. There are also other methods that consider the mental structure and are tailored to provide strong connections between statistics and education. These methods often involve model assumption and parameter estimation, and are complicated mathematically. The dissertation provides a practical view of some advanced quantitative assessment methods. The common feature of these methods is that they all make educational/psychological model assumptions beyond the minimum mathematical model. The purpose of the study is to provide a comparison between these advanced methods and the pure mathematical methods. The comparison is based on the performance of the two types of methods under physics education settings. In particular, the comparison uses both physics content assessments and scientific ability assessments. The dissertation includes three

  2. Hepatocyte and Sertoli Cell Aquaporins, Recent Advances and Research Trends

    PubMed Central

    Bernardino, Raquel L.; Marinelli, Raul A.; Maggio, Anna; Gena, Patrizia; Cataldo, Ilaria; Alves, Marco G.; Svelto, Maria; Oliveira, Pedro F.; Calamita, Giuseppe

    2016-01-01

    Aquaporins (AQPs) are proteinaceous channels widespread in nature where they allow facilitated permeation of water and uncharged through cellular membranes. AQPs play a number of important roles in both health and disease. This review focuses on the most recent advances and research trends regarding the expression and modulation, as well as physiological and pathophysiological functions of AQPs in hepatocytes and Sertoli cells (SCs). Besides their involvement in bile formation, hepatocyte AQPs are involved in maintaining energy balance acting in hepatic gluconeogenesis and lipid metabolism, and in critical processes such as ammonia detoxification and mitochondrial output of hydrogen peroxide. Roles are played in clinical disorders including fatty liver disease, diabetes, obesity, cholestasis, hepatic cirrhosis and hepatocarcinoma. In the seminiferous tubules, particularly in SCs, AQPs are also widely expressed and seem to be implicated in the various stages of spermatogenesis. Like in hepatocytes, AQPs may be involved in maintaining energy homeostasis in these cells and have a major role in the metabolic cooperation established in the testicular tissue. Altogether, this information represents the mainstay of current and future investigation in an expanding field. PMID:27409609

  3. Diamagnetic loop measurement in Korea Superconducting Tokamak Advanced Research machine.

    PubMed

    Bak, J G; Lee, S G; Kim, H S

    2011-06-01

    Diamagnetic loop (DL), which consists of two poloidal loops inside the vacuum vessel, is used to measure the diamagnetic flux during a plasma discharge in the Korea Superconducting Tokamak Advanced Research (KSTAR) machine. The vacuum fluxes in the DL signal can be compensated up to 0.1 mWb by using the coefficients, which are obtained from experimental investigations, in the vacuum flux measurements during vacuum shots under same operational conditions of magnetic coils for plasma experiment in the KSTAR machine. The maximum error in the diamagnetic flux measurement due to the errors of the coefficients was estimated as ∼0.22 mWb. From the diamagnetic flux measurements for the ohmically heated circular plasmas in the KSTAR machine, the stored energy agrees well with the estimated kinetic energy within the discrepancy of 25%. When the electron cyclotron heating, the neutral beam injection, and the ion cyclotron resonance heating are added to the ohmically heated limiter plasmas, the additional heating effects can be clearly observed from the increase of the stored energy evaluated in the DL measurement.

  4. Diamagnetic loop measurement in Korea Superconducting Tokamak Advanced Research machine

    SciTech Connect

    Bak, J. G.; Lee, S. G.; Kim, H. S.

    2011-06-15

    Diamagnetic loop (DL), which consists of two poloidal loops inside the vacuum vessel, is used to measure the diamagnetic flux during a plasma discharge in the Korea Superconducting Tokamak Advanced Research (KSTAR) machine. The vacuum fluxes in the DL signal can be compensated up to 0.1 mWb by using the coefficients, which are obtained from experimental investigations, in the vacuum flux measurements during vacuum shots under same operational conditions of magnetic coils for plasma experiment in the KSTAR machine. The maximum error in the diamagnetic flux measurement due to the errors of the coefficients was estimated as {approx}0.22 mWb. From the diamagnetic flux measurements for the ohmically heated circular plasmas in the KSTAR machine, the stored energy agrees well with the estimated kinetic energy within the discrepancy of 25%. When the electron cyclotron heating, the neutral beam injection, and the ion cyclotron resonance heating are added to the ohmically heated limiter plasmas, the additional heating effects can be clearly observed from the increase of the stored energy evaluated in the DL measurement.

  5. [Research advances in heavy metals pollution ecology of diatom].

    PubMed

    Ding, Teng-Da; Ni, Wan-Min; Zhang, Jian-Ying

    2012-03-01

    Diatom, due to its high sensitivity to environmental change, is one of the bio-indicators of aquatic ecosystem health, and some typical diatom species have been applied to indicate the heavy metals pollution of water body. With the focus on the surface water heavy metals pollution, this paper reviewed the research advances in the toxic effect of heavy metals pollution on diatom, biosorption and bioaccumulation of heavy metals by diatom, ecological adaptation mechanisms of diatom to heavy metals pollution, and roles of diatom as bio-indicator and in ecological restoration of heavy metals pollution. The growth tendency of diatom and the morphological change of frustule under heavy metals pollution as well as the differences in heavy metals biosorption and bioaccumulation by diatom, the ecological adaptation mechanisms of diatom on heavy metals surface complexation and ion exchange, and the roles of diatom as bio-indicator and in ecological restoration of heavy metals polluted water body were also discussed. This review could provide scientific evidences for the prevention of aquatic ecosystems heavy metals pollution and related early warning techniques.

  6. Hydrogen production from water: Recent advances in photosynthesis research

    SciTech Connect

    Greenbaum, E.; Lee, J.W.

    1997-12-31

    The great potential of hydrogen production by microalgal water splitting is predicated on quantitative measurement of the algae`s hydrogen-producing capability, which is based on the following: (1) the photosynthetic unit size of hydrogen production; (2) the turnover time of photosynthetic hydrogen production; (3) thermodynamic efficiencies of conversion of light energy into the Gibbs free energy of molecular hydrogen; (4) photosynthetic hydrogen production from sea water using marine algae; (5) the potential for research advances using modern methods of molecular biology and genetic engineering to maximize hydrogen production. ORNL has shown that sustained simultaneous photoevolution of molecular hydrogen and oxygen can be performed with mutants of the green alga Chlamydomonas reinhardtii that lack a detectable level of the Photosystem I light reaction. This result is surprising in view of the standard two-light reaction model of photosynthesis and has interesting scientific and technological implications. This ORNL discovery also has potentially important implications for maximum thermodynamic conversion efficiency of light energy into chemical energy by green plant photosynthesis. Hydrogen production performed by a single light reaction, as opposed to two, implies a doubling of the theoretically maximum thermodynamic conversion efficiency from {approx}10% to {approx}20%.

  7. Recent theoretical, neural, and clinical advances in sustained attention research.

    PubMed

    Fortenbaugh, Francesca C; DeGutis, Joseph; Esterman, Michael

    2017-03-05

    Models of attention often distinguish among attention subtypes, with classic models separating orienting, switching, and sustaining functions. Compared with other forms of attention, the neurophysiological basis of sustaining attention has received far less notice, yet it is known that momentary failures of sustained attention can have far-ranging negative effects in healthy individuals, and lasting sustained attention deficits are pervasive in clinical populations. In recent years, however, there has been increased interest in characterizing moment-to-moment fluctuations in sustained attention, in addition to the overall vigilance decrement, and understanding how these neurocognitive systems change over the life span and across various clinical populations. The use of novel neuroimaging paradigms and statistical approaches has allowed for better characterization of the neural networks supporting sustained attention and has highlighted dynamic interactions within and across multiple distributed networks that predict behavioral performance. These advances have also provided potential biomarkers to identify individuals with sustained attention deficits. These findings have led to new theoretical models explaining why sustaining focused attention is a challenge for individuals and form the basis for the next generation of sustained attention research, which seeks to accurately diagnose and develop theoretically driven treatments for sustained attention deficits that affect a variety of clinical populations.

  8. Review: Advances in delta-subsidence research using satellite methods

    NASA Astrophysics Data System (ADS)

    Higgins, Stephanie A.

    2016-05-01

    Most of the world's major river deltas are sinking relative to local sea level. The effects of subsidence can include aquifer salinization, infrastructure damage, increased vulnerability to flooding and storm surges, and permanent inundation of low-lying land. Consequently, determining the relative importance of natural vs. anthropogenic pressures in driving delta subsidence is a topic of ongoing research. This article presents a review of knowledge with respect to delta surface-elevation loss. The field is rapidly advancing due to applications of space-based techniques: InSAR (interferometric synthetic aperture radar), GPS (global positioning system), and satellite ocean altimetry. These techniques have shed new light on a variety of subsidence processes, including tectonics, isostatic adjustment, and the spatial and temporal variability of sediment compaction. They also confirm that subsidence associated with fluid extraction can outpace sea-level rise by up to two orders of magnitude, resulting in effective sea-level rise that is one-hundred times faster than the global average rate. In coming years, space-based and airborne instruments will be critical in providing near-real-time monitoring to facilitate management decisions in sinking deltas. However, ground-based observations continue to be necessary for generating complete measurements of surface-elevation change. Numerical modeling should seek to simulate couplings between subsidence processes for greater predictive power.

  9. Advances in Rodent Research Missions on the International Space Station

    NASA Technical Reports Server (NTRS)

    Choi, S. Y.; Ronca, A.; Leveson-Gower, D.; Gong, C.; Stube, K.; Pletcher, D.; Wigley, C.; Beegle, J.; Globus, R. K.

    2016-01-01

    A research platform for rodent experiment on the ISS is a valuable tool for advancing biomedical research in space. Capabilities offered by the Rodent Research project developed at NASA Ames Research Center can support experiments of much longer duration on the ISS than previous experiments performed on the Space Shuttle. NASAs Rodent Research (RR)-1 mission was completed successfully and achieved a number of objectives, including validation of flight hardware, on-orbit operations, and science capabilities as well as support of a CASIS-sponsored experiment (Novartis) on muscle atrophy. Twenty C57BL6J adult female mice were launched on the Space-X (SpX) 4 Dragon vehicle, and thrived for up to 37 days in microgravity. Daily health checks of the mice were performed during the mission via downlinked video; all flight animals were healthy and displayed normal behavior, and higher levels of physical activity compared to ground controls. Behavioral analysis demonstrated that Flight and Ground Control mice exhibited the same range of behaviors, including eating, drinking, exploratory behavior, self- and allo-grooming, and social interactions indicative of healthy animals. The animals were euthanized on-orbit and select tissues were collected from some of the mice on orbit to assess the long-term sample storage capabilities of the ISS. In general, the data obtained from the flight mice were comparable to those from the three groups of control mice (baseline, vivarium and ground controls, which were housed in flight hardware), showing that the ISS has adequate capability to support long-duration rodent experiments. The team recovered 35 tissues from 40 RR-1 frozen carcasses, yielding 3300 aliquots of tissues to distribute to the scientific community in the U.S., including NASAs GeneLab project and scientists via Space Biology's Biospecimen Sharing Program Ames Life Science Data Archive. Tissues also were distributed to Russian research colleagues at the Institute for

  10. Advanced Photon Source research: Volume 1, Number 1, April 1998

    SciTech Connect

    1998-04-01

    The following articles are included in this publication: (1) The Advanced Photon Source: A Brief Overview; (2) MAD Analysis of FHIT at the Structural Biology Center; (3) Advances in High-Energy-Resolution X-ray Scattering at Beamline 3-ID; (4) X-ray Imaging and Microspectroscopy of the Mycorrhyizal Fungus-Plant Symbiosis; (5) Measurement and Control of Particle-beam Trajectories in the Advanced Photon Storage Ring; (6) Beam Acceleration and Storage at the Advanced Photon Source; and (7) Experimental Facilities Operations and Current Status.

  11. Advancing Transdisciplinary Research: The Transdisciplinary Research on Energetics and Cancer Initiative.

    PubMed

    Gehlert, Sarah; Hall, Kara; Vogel, Amanda; Hohl, Sarah; Hartman, Sheri; Nebeling, Linda; Redline, Susan; Schmitz, Kathryn; Thornquist, Mark; Patterson, Ruth; Thompson, Beti

    2014-09-01

    Strategies for constructing and maintaining cross-disciplinary teams are in their infancy. We outline strategies to support one form, transdisciplinary research, in a major initiative of the National Cancer Institute, the Transdisciplinary Research in Energetics and Cancer 2 (TREC2) initiative. Discussion of the TREC2 sites' experiences with transdisciplinarity is structured around a conceptual model that identifies four iterative phases of transdisciplinary research. An active coordination center, regular face-to-face meetings, and input from external advisors were instrumental in moving TREC2 to the translation phase. The possibilities for advancements in the science of energetics and cancer increased as investigator ties became denser. TREC2 can be seen as a flagship effort in transdisciplinary science that provides lessons on moving ideas from development to translation.

  12. Advanced Low-Noise Research Fan Stage Design

    NASA Technical Reports Server (NTRS)

    Neubert, Robert; Bock, Larry; Malmborg, Eric; Owen-Peer, William

    1997-01-01

    This report describes the design of the Advanced Low-Noise Research Fan stage. The fan is a variable pitch design, which is designed at the cruise pitch condition. Relative to the cruise setting, the blade is closed at takeoff and opened for reverse thrust operation. The fan stage is a split flow design with fan exit guide vanes (FEGVs) and core stators. The fan stage design is combined with a nacelle and engine core duct to form a powered fan/nacelle subscale model. This model is intended for use in combined aerodynamic, acoustic, and structural testing in a wind tunnel. The fan has an outer diameter of 22 in. and a hub-to-tip of 0.426 in., which allows the use of existing NASA fan and cowl force balance and rig drive systems. The design parameters were selected to permit valid acoustic and aerodynamic comparisons with the Pratt & Whitney (P&W) 17- and 22-in. rigs previously tested under NASA contract. The fan stage design is described in detail. The results of the design axisymmetric and Navier-Stokes aerodynamic analysis are presented at the critical design conditions. The structural analysis of the fan rotor and attachment is included. The blade and attachment are predicted to have adequate low-cycle fatigue life and an acceptable operating range without resonant stress or flutter. The stage was acoustically designed with airfoil counts in the FEGV and core stator to minimize noise. A fan/FEGV tone analysis developed separately under NASA contract was used to determine the optimum airfoil counts. The fan stage was matched to the existing nacelle, designed under the previous P&W low-noise contract, to form a fan/nacelle model for wind tunnel testing. It is an axisymmetric nacelle for convenience in testing and analysis. Previous testing confirmed that the nacelle performed as required at various aircraft operating conditions.

  13. A programmable sound processor for advanced hearing aid research.

    PubMed

    McDermott, H

    1998-03-01

    A portable sound processor has been developed to facilitate research on advanced hearing aids. Because it is based on a digital signal processing integrated circuit (Motorola DSP56001), it can readily be programmed to execute novel algorithms. Furthermore, the parameters of these algorithms can be adjusted quickly and easily to suit the specific hearing characteristics of users. In the processor, microphone signals are digitized to a precision of 12 bits at a sampling rate of approximately 12 kHz for input to the DSP device. Subsequently, processed samples are delivered to the earphone by a novel, fully-digital class-D driver. This driver provides the advantages of a conventional class-D amplifier (high maximum output, low power consumption, low distortion) without some of the disadvantages (such as the need for precise analog circuitry). In addition, a cochlear implant driver is provided so that the processor is suitable for hearing-impaired people who use an implant and an acoustic hearing aid together. To reduce the computational demands on the DSP device, and therefore the power consumption, a running spectral analysis of incoming signals is provided by a custom-designed switched-capacitor integrated circuit incorporating 20 bandpass filters. The complete processor is pocket-sized and powered by batteries. An example is described of its use in providing frequency-shaped amplification for aid users with severe hearing impairment. Speech perception tests confirmed that the processor performed significantly better than the subjects' own hearing aids, probably because the digital filter provided a frequency response generally closer to the optimum for each user than the simpler analog aids.

  14. Research advances on animal genetics in China in 2015.

    PubMed

    Bo, Zhang; Xiaofang, Chen; Xun, Huang; Xiao, Yang

    2016-06-20

    -wide genetic basis of the species-specific physiological and pathological characteristics as well as their adaptation to environmental conditions. In this review, we make a first attempt to summarize the research advances on animal genetics in China in 2015, with an emphasis on the achievements led by Chinese scientists and carried out in Chinese institutions. We will briefly discuss the significance of their research and contributions of Chinese scientists in animal genetics.

  15. Research Priorities in the Seminary Professorate: Scholarly Research and Academic Writing as Criterion for Rank Advancement in Graduate Theological Education

    ERIC Educational Resources Information Center

    Bell, Skip

    2005-01-01

    The purpose of this investigation was to surface definitions for scholarly research employed in Association of Theological Schools seminaries, identify the application of scholarly research as a criteria for rank advancement, and form a scholarly research productivity reference point. The research revealed that while definitions of scholarly…

  16. Status and future directions for advanced accelerator research - conventional and non-conventional collider concepts

    SciTech Connect

    Siemann, R.H.

    1997-01-01

    The relationship between advanced accelerator research and future directions for particle physics is discussed. Comments are made about accelerator research trends in hadron colliders, muon colliders, and e{sup +}3{sup {minus}} linear colliders.

  17. Brain barriers and brain fluid research in 2016: advances, challenges and controversies.

    PubMed

    Keep, Richard F; Jones, Hazel C; Drewes, Lester R

    2017-02-02

    This editorial highlights some of the advances that occurred in relation to brain barriers and brain fluid research in 2016. It also aims to raise some of the attendant controversies and challenges in such research.

  18. Gout: History, Research, and Recent NIH–Supported Advances | NIH MedlinePlus the Magazine

    MedlinePlus

    ... please turn Javascript on. Feature: Detecting and Treating Gout Gout: History, Research, and Recent NIH–Supported Advances Past ... History of Medicine Division, National Library of Medicine Gout—Before Modern Medicine Before medical research discovered the ...

  19. ac powertrain for an electric vehicle. Phase 2 and Phase 3 final report

    SciTech Connect

    Slicker, J.M.

    1984-11-01

    This report describes work relating to Phases 2 and 3 development and testing of an ac powertrain for a 25 hp four-passenger electric vehicle. The system, which consists of a two-speed automatic mechanical transaxle, 18.6 kW ac induction traction motor, 33.6 kW inverter and overall logic controller, was installed and evaluated in a converted Mercury Lynx rolling test bed vehicle. An on-board charger and an auxiliary dc-to-dc converter were integrated into the inverter/controller package.

  20. 2009 Biospecimen research network symposium: advancing cancer research through biospecimen science.

    PubMed

    Moore, Helen M; Compton, Carolyn C; Lim, Mark D; Vaught, Jimmie; Christiansen, Katerina N; Alper, Joe

    2009-09-01

    This report details the proceedings of the 2009 Biospecimen Research Network (BRN) Symposium that took place on March 16 to 18, 2009, the second in a series of annual symposia sponsored by the National Cancer Institute Office of Biorepositories and Biospecimen Research. The BRN Symposium is a public forum addressing the relevance of biospecimen quality to progress in cancer research and the systematic investigation needed to understand how different methods of collection, processing, and storage of human biospecimens affect subsequent molecular research results. More than 300 participants from industry, academia, and government attended the symposium, which featured both formal presentations and a day of workshops aimed at addressing several key issues in biospecimen science. An additional 100 individuals participated via a live webcast (archived at http://brnsymposium.com). The BRN Symposium is part of a larger program designed as a networked, multidisciplinary research approach to increase the knowledge base for biospecimen science. Biospecimens are generally understood to represent an accurate representation of a patient's disease biology, but can instead reflect a combination of disease biology and the biospecimen's response to a wide range of biological stresses. The molecular signatures of disease can thus be confounded by the signatures of biospecimen biological stress, with the potential to affect clinical and research outcomes through incorrect diagnosis of disease, improper use of a given therapy, and irreproducible research results that can lead to misinterpretation of artifacts as biomarkers. Biospecimen research represents the kind of bricks-and-mortar research that provides a solid scientific foundation for future advances that will directly help patients.

  1. 76 FR 52954 - Workshop: Advancing Research on Mixtures; New Perspectives and Approaches for Predicting Adverse...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-24

    ... HUMAN SERVICES Workshop: Advancing Research on Mixtures; New Perspectives and Approaches for Predicting... ``Advancing Research on Mixtures: New Perspectives and Approaches for Predicting Adverse Human Health Effects....niehs.nih.gov/conferences/dert/mixtures/ . The deadline to register for this workshop is...

  2. Research and development on the application of advanced control technologies to advanced nuclear reactor systems: A US national perspective

    SciTech Connect

    White, J.D.; Monson, L.R.; Carrol, D.G.; Dayal, Y.; Argonne National Lab., IL; General Electric Co., San Jose, CA )

    1989-01-01

    Control system designs for nuclear power plants are becoming more advanced through the use of digital technology and automation. This evolution is taking place because of: (1) the limitations in analog based control system performance and maintenance and availability and (2) the promise of significant improvement in plant operation and availability due to advances in digital and other control technologies. Digital retrofits of control systems in US nuclear plants are occurring now. Designs of control and protection systems for advanced LWRs are based on digital technology. The use of small inexpensive, fast, large-capacity computers in these designs is the first step of an evolutionary process described in this paper. Under the sponsorship of the US Department of Energy (DOE), Oak Ridge National Laboratory, Argonne National Laboratory, GE Nuclear Energy and several universities are performing research and development in the application of advances in control theory, software engineering, advanced computer architectures, artificial intelligence, and man-machine interface analysis to control system design. The target plant concept for the work described in this paper is the Power Reactor Inherently Safe Module reactor (PRISM), an advanced modular liquid metal reactor concept. This and other reactor designs which provide strong passive responses to operational upsets or accidents afford good opportunities to apply these advances in control technology. 18 refs., 5 figs.

  3. Advanced Research Training in Human Geography: The Scottish Experience

    ERIC Educational Resources Information Center

    Gwanzura-Ottemoeller, Fungisai; Hopkins, Peter; Lorimer, Hayden; Philip, Lorna J.

    2005-01-01

    Formal research training is integral to research degrees in human geography completed in UK higher education institutions today. The Economic and Social Research Council (ESRC) has been the driving force behind the formalization of research training. Arguably less well known among the ESRC research training recommendations is the stipulation that…

  4. Meeting Reports for 2013: Recent Advances in Breath Biomarker Research

    EPA Science Inventory

    This article reports the efforts of the breath research community affiliated with the International Association of Breath Research (IABR) in disseminating research results in high profile technical meetings in the United States (US). Specifically, we describe presentations at a ...

  5. Space research policies in advanced and developing countries

    NASA Astrophysics Data System (ADS)

    Roederer, Juan G.

    The motivations for the conduct of space research and the development of space research policies by different constituencies and different types of countries are analyzed. Concerning space research in developing countries, four main aspects are discussed: 1. The role of space research for the achievement of ``critical mass'' by research groups; 2. The role of space research in higher education; 3. The identification of space research problems to which a country can make significant contributions; and 4. Multinational cooperation among developing countries in space research.

  6. Advanced vehicle systems assessment. Volume 2: Subsystems assessment

    NASA Technical Reports Server (NTRS)

    Hardy, K.

    1985-01-01

    Volume 2 (Subsystems Assessment) is part of a five-volume report entitled Advanced Vehicle Systems Assessment. Volume 2 presents the projected performance capabilities and cost characteristics of applicable subsystems, considering an additional decade of development. Subsystems of interest include energy storage and conversion devices as well as the necessary powertrain components and vehicle subsystems. Volume 2 also includes updated battery information based on the assessment of an independent battery review board (with the aid of subcontractor reports on advanced battery characteristics).

  7. Development of an advanced high-speed rotor - Final results from the Advanced Flight Research Rotor program

    NASA Technical Reports Server (NTRS)

    Jenks, Mark; Haslim, Leonard

    1988-01-01

    The final results of the Advanced Flight Research Rotor (AFRR) study, a NASA sponsored research program, are summarized. First, the results of the initial phase of the AFRR program, consisting of the definition of a conventional rotor with planform and prescribed twist distributions, are briefly reviewed. The mechanism of the calculated performance benefit is then explained, and a detailed analysis of the prescribed twist distribution is presented. Recommendations are made on the practical means of approximating the prescribed twist on the actual rotor.

  8. Applying the circuit theory to the development of an algorithm for designing the pneumohydraulic system of a spacecraft powertrain

    NASA Astrophysics Data System (ADS)

    Aristov, V. P.; Telepnev, P. P.; Ermakov, V. Yu.

    2013-12-01

    This article considers the application of circuit theory methods for developing a mathematical model of the branched pneumohydraulic system (PHS) of a spacecraft powertrain (PT). The parts of the PHS are treated as elements with lumped constants. The design principles are defined. The methodology for developing a mathematical model for the PHS is described.

  9. Design of energy-efficient MRF-based clutches with defined fail-safe behavior for integration in hybrid powertrains

    NASA Astrophysics Data System (ADS)

    Erbis, Vadim; Hegger, Christian; Güth, Dirk; Maas, Jürgen

    2015-04-01

    Drag losses in the powertrain are a serious deficiency for any energy-efficient application, especially for hybrid electrical vehicles. A promising approach for fulfilling requirements like efficiency, wear, safety and dynamics is the use of an innovative MRF-based clutch design for the transmission of power that is based on magnetorheological fluids (MRF). MRF are smart fluids with the particular characteristics of changing their apparent viscosity significantly under influence of the magnetic field. Their characteristics are fast switching times and a smooth torque control in the powertrain. In this paper, a novel clutch concept is investigated that facilitates the controlled movement of the MRF from an active torque-transmitting region into an inactive region of the shear gap. This concept enables a complete disengagement of the fluid engaging surfaces in a way that viscous drag torque can be eliminated. Therefore, a simulation based design for such MRF-based clutches is used to design the required magnetic excitation systems for enabling a well-defined safety behavior by the fluid control. Based on this approach, an MRF-based clutch is developed in detail which provides a loss-reduced alternative to conventional disengagement devices in the powertrain. The presented MRF-based clutch enables a investigation of different systems in one design by changing the magnetic excitation. Especially, different possibilities for the fail-safe behavior of the MRF-based clutch are considered to ensure a well-defined condition in electrical or hybrid powertrains in case of a system failure.

  10. 77 FR 56870 - New Process Gear, a Division of Magna Powertrain, Including On-Site Leased Workers From ABM...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    ... Leased Workers From ABM Janitorial Service Northeast, Inc., and IS One, Inc., East Syracuse, NY; Amended...). The notice was amended on June 21, 2012 to include on-site leased workers from ABM Janitorial Service... Syracuse, New York location of New Process Gear, a division of Magna Powertrain. The Department...

  11. NASA advanced turboprop research and concept validation program

    NASA Technical Reports Server (NTRS)

    Whitlow, John B., Jr.; Sievers, G. Keith

    1988-01-01

    NASA has determined by experimental and analytical effort that use of advanced turboprop propulsion instead of the conventional turbofans in the older narrow-body airline fleet could reduce fuel consumption for this type of aircraft by up to 50 percent. In cooperation with industry, NASA has defined and implemented an Advanced Turboprop (ATP) program to develop and validate the technology required for these new high-speed, multibladed, thin, swept propeller concepts. This paper presents an overview of the analysis, model-scale test, and large-scale flight test elements of the program together with preliminary test results, as available.

  12. Advanced cogeneration research study. Survey of cogeneration potential

    NASA Technical Reports Server (NTRS)

    Slonski, M. L.

    1983-01-01

    Fifty-five facilities that consumed substantial amounts of electricity, natural gas, or fuel oil were surveyed by telephone in 1983. The primary objective of the survey was to estimate the potential electricity that could be generated in the SCE service territory using cogeneration technology. An estimated 3667 MW sub e could potentially be generated using cogenerated technology. Of this total, current technology could provide 2569 MW sub p and advanced technology could provide 1098 MW sub e. Approximately 1611 MW sub t was considered not feasible to produce electricity with either current or advanced cogeneration technology.

  13. Space Launch System NASA Research Announcement Advanced Booster Engineering Demonstration and/or Risk Reduction

    NASA Technical Reports Server (NTRS)

    Crumbly, Christopher M.; Craig, Kellie D.

    2011-01-01

    The intent of the Advanced Booster Engineering Demonstration and/or Risk Reduction (ABEDRR) effort is to: (1) Reduce risks leading to an affordable Advanced Booster that meets the evolved capabilities of SLS (2) Enable competition by mitigating targeted Advanced Booster risks to enhance SLS affordability. Key Concepts (1) Offerors must propose an Advanced Booster concept that meets SLS Program requirements (2) Engineering Demonstration and/or Risk Reduction must relate to the Offeror s Advanced Booster concept (3) NASA Research Announcement (NRA) will not be prescriptive in defining Engineering Demonstration and/or Risk Reduction

  14. Comparative Study of Hybrid Powertrains on Fuel Saving, Emissions, and Component Energy Loss in HD Trucks

    DOE PAGES

    Gao, Zhiming; Finney, Charles; Daw, Charles; ...

    2014-09-30

    We compared parallel and series hybrid powertrains on fuel economy, component energy loss, and emissions control in Class 8 trucks over both city and highway driving. A comprehensive set of component models describing battery energy, engine fuel efficiency, emissions control, and power demand interactions for heavy duty (HD) hybrids has been integrated with parallel and series hybrid Class 8 trucks in order to identify the technical barriers of these hybrid powertrain technologies. The results show that series hybrid is absolutely negative for fuel economy benefit of long-haul trucks due to an efficiency penalty associated with the dual-step conversions of energymore » (i.e. mechanical to electric to mechanical). The current parallel hybrid technology combined with 50% auxiliary load reduction could elevate 5-7% fuel economy of long-haul trucks, but a profound improvement of long-haul truck fuel economy requires additional innovative technologies for reducing aerodynamic drag and rolling resistance losses. The simulated emissions control indicates that hybrid trucks reduce more CO and HC emissions than conventional trucks. The simulated results further indicate that the catalyzed DPF played an important role in CO oxidations. Limited NH3 emissions could be slipped from the Urea SCR, but the average NH3 emissions are below 20 ppm. Meanwhile our estimations show 1.5-1.9% of equivalent fuel-cost penalty due to urea consumption in the simulated SCR cases.« less

  15. Comparative Study of Hybrid Powertrains on Fuel Saving, Emissions, and Component Energy Loss in HD Trucks

    SciTech Connect

    Gao, Zhiming; Finney, Charles; Daw, Charles; LaClair, Tim J.; Smith, David

    2014-09-30

    We compared parallel and series hybrid powertrains on fuel economy, component energy loss, and emissions control in Class 8 trucks over both city and highway driving. A comprehensive set of component models describing battery energy, engine fuel efficiency, emissions control, and power demand interactions for heavy duty (HD) hybrids has been integrated with parallel and series hybrid Class 8 trucks in order to identify the technical barriers of these hybrid powertrain technologies. The results show that series hybrid is absolutely negative for fuel economy benefit of long-haul trucks due to an efficiency penalty associated with the dual-step conversions of energy (i.e. mechanical to electric to mechanical). The current parallel hybrid technology combined with 50% auxiliary load reduction could elevate 5-7% fuel economy of long-haul trucks, but a profound improvement of long-haul truck fuel economy requires additional innovative technologies for reducing aerodynamic drag and rolling resistance losses. The simulated emissions control indicates that hybrid trucks reduce more CO and HC emissions than conventional trucks. The simulated results further indicate that the catalyzed DPF played an important role in CO oxidations. Limited NH3 emissions could be slipped from the Urea SCR, but the average NH3 emissions are below 20 ppm. Meanwhile our estimations show 1.5-1.9% of equivalent fuel-cost penalty due to urea consumption in the simulated SCR cases.

  16. Speed synchronization control for integrated automotive motor-transmission powertrain system with random delays

    NASA Astrophysics Data System (ADS)

    Zhu, Xiaoyuan; Zhang, Hui; Fang, Zongde

    2015-12-01

    This paper presents a robust speed synchronization controller design for an integrated motor-transmission powertrain system in which the driving motor and multi-gearbox are directly coupled. As the controller area network (CAN) is commonly used in the vehicle powertrain system, the possible network-induced random delays in both feedback and forward channel are considered and modeled by using two Markov chains in the controller design process. For the application perspective, the control law adopted here is a generalized proportional-integral (PI) control. By employing the system-augmentation technique, a delay-free stochastic closed-loop system is obtained and the generalized PI controller design problem is converted to a static output feedback (SOF) controller design problem. Since there are external disturbances involved in the closed-loop system, the energy-to-peak performance is considered to guarantee the robustness of the controller. And the controlled output is chosen as the speed synchronization error. To further improve the transient response of the closed-loop system, the pole placement is also employed in the energy-to-peak performance based speed synchronization control. The mode-dependent control gains are obtained by using an iterative linear matrix inequality (LMI) algorithm. Simulation results show the effectiveness of the proposed control approach.

  17. Advanced gasification projects. [Support research needs; contains list of advanced gasification projects supported by US DOE

    SciTech Connect

    Not Available

    1982-02-01

    An analysis of the needs for coal gasification reveals the following principal categories of information gaps that can be filled by programs already in progress or those readily initiated. The gaps are technology base needs required for successful application of both currently available and advanced gasification processes. The need areas are classified as follows: Reactor design/performance, gas cleaning/cooling separation, acid-gas removal/gas shift/gas conversion, wastewater treatment, and general data base on both state-of-the-art and advanced technologies. During the future operating and optimization phases of most of the coal gasification projects, when additional troubles will surface, the technical support program described herein will have provided the additional data base needed to correct deficiencies and/or to advance the state-of-the-art. The report describes US DOE supported projects in this area: brief description, title, contractor, objective, accomplishments, current work and possible application.

  18. Advancing High-Quality Literacy Research in Juvenile Justice: Methodological and Practical Considerations

    ERIC Educational Resources Information Center

    Houchins, David E.; Jolivette, Kristine; Shippen, Margaret E.; Lambert, Richard

    2010-01-01

    Special education researchers have made noteworthy progress toward conceptualizing literacy research questions, designing quality studies, and disseminating the results of their research. These advancements have been made through the establishment and refinement of quality research indicators. Unfortunately, this progress has mostly eluded the…

  19. First 3 years of operation of RIACS (Research Institute for Advanced Computer Science) (1983-1985)

    NASA Technical Reports Server (NTRS)

    Denning, P. J.

    1986-01-01

    The focus of the Research Institute for Advanced Computer Science (RIACS) is to explore matches between advanced computing architectures and the processes of scientific research. An architecture evaluation of the MIT static dataflow machine, specification of a graphical language for expressing distributed computations, and specification of an expert system for aiding in grid generation for two-dimensional flow problems was initiated. Research projects for 1984 and 1985 are summarized.

  20. Advances take stage - Office of Cancer Clinical Proteomics Research

    Cancer.gov

    Regulatory advances in proteomics will be taking center stage at a Symposia scheduled to occur at the 2011 American Association for Clinical Chemistry (AACC) Annual Meeting. The symposium entitled "Enabling Translational Proteomics with NCI's Clinical Proteomic Technologies for Cancer" is scheduled for July 25, 2011 at AACC's annual Meeting.

  1. Advances in pancreatic cancer research: moving towards early detection.

    PubMed

    He, Xiang-Yi; Yuan, Yao-Zong

    2014-08-28

    Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms of cancer. Substantial progress has been made in the understanding of the biology of pancreatic cancer, and advances in patient management have been significant. However, most patients (nearly 80%) who present with locally advanced or metastatic disease have an extremely poor prognosis. Survival is better for those with malignant disease localized to the pancreas, because surgical resection at present offers the only chance of cure. Therefore, the early detection of pancreatic cancer may benefit patients with PDAC. However, its low rate of incidence and the limitations of current screening strategies make early detection difficult. Recent advances in the understanding of the pathogenesis of PDAC suggest that it is possible to detect PDAC in early stages and even identify precursor lesions. The presence of new-onset diabetes mellitus in the early phase of pancreatic cancer may provide clues for its early diagnosis. Advances in the identification of novel circulating biomarkers including serological signatures, autoantibodies, epigenetic markers, circulating tumor cells and microRNAs suggest that they can be used as potential tools for the screening of precursors and early stage PDAC in the future. However, proper screening strategies based on effective screening methodologies need to be tested for clinical application.

  2. 2013 Summary of Advances in Autism Spectrum Disorder Research

    ERIC Educational Resources Information Center

    Interagency Autism Coordinating Committee, 2014

    2014-01-01

    Each year, the Interagency Autism Coordinating Committee (IACC) releases its annual list of scientific advances that represent significant progress in the field. The 20 studies selected have given new insight into the complex causes of autism and potential risk factors, studied clues that could lead to earlier diagnosis, and evaluated promising…

  3. School Integration Matters: Research-Based Strategies to Advance Equity

    ERIC Educational Resources Information Center

    Frankenberg, Erica, Ed.; Garces, Liliana M., Ed.; Hopkins, Megan, Ed.

    2016-01-01

    More than 60 years after the "Brown v. Board of Education" decision declared segregated schooling inherently unequal, this timely book sheds light on how and why U.S. schools are experiencing increasing segregation along racial, socioeconomic, and linguistic lines. It offers policy and programmatic alternatives for advancing equity and…

  4. Advanced Measurement Technology at NASA Langley Research Center

    NASA Technical Reports Server (NTRS)

    Antcliff, Richard R.

    1998-01-01

    Instrumentation systems have always been essential components of world class wind tunnels and laboratories. Langley continues to be on the forefront of the development of advanced systems for aerospace applications. This paper will describe recent advances in selected measurement systems which have had significant impact on aerospace testing. To fully understand the aerodynamics and aerothermodynamics influencing aerospace vehicles, highly accurate and repeatable measurements need to be made of critical phenomena. However, to maintain leadership in a highly competitive world market, productivity enhancement and the development of new capabilities must also be addressed aggressively. The accomplishment of these sometimes conflicting requirements has been the challenge of advanced measurement developers. However, several new technologies have recently matured to the point where they have enabled the achievement of these goals. One of the critical areas where advanced measurement systems are required is flow field velocity measurements. These measurements are required to correctly characterize the flowfield under study, to quantify the aerodynamic performance of test articles and to assess the effect of aerodynamic vehicles on their environment. Advanced measurement systems are also making great strides in obtaining planar measurements of other important thermodynamic quantities, including species concentration, temperature, pressure and the speed of sound. Langley has been on the forefront of applying these technologies to practical wind tunnel environments. New capabilities in Projection Moire Interferometry and Acoustics Array Measurement systems have extended our capabilities into the model deformation, vibration and noise measurement arenas. An overview of the status of these techniques and recent applications in practical environments will be presented in this paper.

  5. Experimental Advanced Airborne Research Lidar (EAARL) Data Processing Manual

    USGS Publications Warehouse

    Bonisteel, Jamie M.; Nayegandhi, Amar; Wright, C. Wayne; Brock, John C.; Nagle, David

    2009-01-01

    The Experimental Advanced Airborne Research Lidar (EAARL) is an example of a Light Detection and Ranging (Lidar) system that utilizes a blue-green wavelength (532 nanometers) to determine the distance to an object. The distance is determined by recording the travel time of a transmitted pulse at the speed of light (fig. 1). This system uses raster laser scanning with full-waveform (multi-peak) resolving capabilities to measure submerged topography and adjacent coastal land elevations simultaneously (Nayegandhi and others, 2009). This document reviews procedures for the post-processing of EAARL data using the custom-built Airborne Lidar Processing System (ALPS). ALPS software was developed in an open-source programming environment operated on a Linux platform. It has the ability to combine the laser return backscatter digitized at 1-nanosecond intervals with aircraft positioning information. This solution enables the exploration and processing of the EAARL data in an interactive or batch mode. ALPS also includes modules for the creation of bare earth, canopy-top, and submerged topography Digital Elevation Models (DEMs). The EAARL system uses an Earth-centered coordinate and reference system that removes the necessity to reference submerged topography data relative to water level or tide gages (Nayegandhi and others, 2006). The EAARL system can be mounted in an array of small twin-engine aircraft that operate at 300 meters above ground level (AGL) at a speed of 60 meters per second (117 knots). While other systems strive to maximize operational depth limits, EAARL has a narrow transmit beam and receiver field of view (1.5 to 2 milliradians), which improves the depth-measurement accuracy in shallow, clear water but limits the maximum depth to about 1.5 Secchi disk depth (~20 meters) in clear water. The laser transmitter [Continuum EPO-5000 yttrium aluminum garnet (YAG)] produces up to 5,000 short-duration (1.2 nanosecond), low-power (70 microjoules) pulses each second

  6. ADVANCES IN DIETARY EXPOSURE RESEARCH AT THE UNITED STATES

    EPA Science Inventory

    The United States Environmental Protection Agency-National Exposure Research Laboratory's (USEPA-NERL)dietary exposure research program investigates the role of diet, including drinking water, as a potential pathway of human exposure to environmental contaminants. A primary progr...

  7. Advancing the Therapeutic Massage Research Agenda(s)

    PubMed Central

    Porcino, Antony J.

    2013-01-01

    Therapeutic massage and bodywork (TMB) is now an established field of research with dedicated funding, researchers, and many venues and channels for dissemination of TMB research. Research agendas are a way for a profession to focus the development and funding of research on facets of TMB practice and education that are most needed at a given point of time to best move forward the practice and professionalization of TMB. Of the two TMB research agendas, one is currently being updated, the other is newly developed. Because of the impact on the development of the profession, gaps in research agendas also need to be carefully considered. Three areas that could use further consideration or support within the current agendas include education, methods and methodologies, and underlying assumptions. TMB researchers need to engage with and support the current agendas, and participate in their evolution. PMID:24000302

  8. Narrative Abilities: Advances in Research and Implications for Clinical Practice

    ERIC Educational Resources Information Center

    Boudreau, Donna

    2008-01-01

    The article discusses the key findings in recent research dealing narrative abilities in children with and without language implications. The implications of research findings for narrative assessment and intervention are discussed.

  9. Breeding and quantitative genetics advances in sunflower Sclerotinia research

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Genetic research of the sunflower research unit, USDA-ARS, in Fargo, ND, was discussed in a presentation to a group of producers, industry representatives, and scientists. The need for sunflower quantitative genetics research to find and capture Sclerotinia resistance is increasing with every year t...

  10. Cooperative Research and Development of Primary Surface Recuperator for Advanced Microturbine Systems

    SciTech Connect

    Escola, George

    2007-01-17

    Recuperators have been identified as key components of advanced gas turbines systems that achieve a measure of improvement in operating efficiency and lead the field in achieving very low emissions. Every gas turbine manufacturer that is studying, developing, or commercializing advanced recuperated gas turbine cycles requests that recuperators operate at higher temperature without a reduction in design life and must cost less. The Solar Cooperative Research and Development of Primary Surface Recuperator for Advanced Microturbine Systems Program is directed towards meeting the future requirements of advanced gas turbine systems by the following: (1) The development of advanced alloys that will allow recuperator inlet exhaust gas temperatures to increase without significant cost increase. (2) Further characterization of the creep and oxidation (dry and humid air) properties of nickel alloy foils (less than 0.13 mm thick) to allow the economical use of these materials. (3) Increasing the use of advanced robotic systems and advanced in-process statistical measurement systems.

  11. Advanced Pediatric Brain Imaging Research and Training Program

    DTIC Science & Technology

    2013-10-01

    injury in children. Dr. Dobson’s project was an investigation of the mechanisms of brain injury in premature infants , and potential neuroprotective...study hypoxic ischemic brain injury in newborns treated with therapeutic hypothermia. Dr. Massaro has a long standing interest in identifying early...TE.Understanding brain injury and neurodevelopmental disabilities in the preterm infant : the evolving role of advanced magnetic resonance imaging.Semin

  12. Advanced steel reheat furnaces: Research and development. Final report

    SciTech Connect

    Nguyen, Q.; Koppang, R.; Maly, P.; Moyeda, D.; Li, X.

    1999-01-14

    The purpose of this report is to present the results of two phases of a three-phase project to develop and evaluate an Advanced Steel Reheat Furnace (SSRF) concept which incorporates two proven and commercialized technologies, oxy-fuel enriched air (OEA) combustion and gas reburning (GR). The combined technologies aim to improve furnace productivity with higher flame radiant heat transfer in the heating zones of a steel reheat furnace while controlling potentially higher NOx emissions from these zones. The project was conducted under a contract sponsored by the Department of Energy (DOE). Specifically, this report summarizes the results of a modeling study and an experimental study to define and evaluate the issues which affect the integration and performance of the combined technologies. Section 2.0 of the report describes the technical approach uses in the development and evaluation of the advanced steel reheat furnace. Section 3.0 presents results of the modeling study applied to a model steel furnace. Experimental validation of the modeling results obtained from EER`s Fuel Evaluation Facility (FEF) pilot-scale furnace discussed in Section 4.0. Section 5.0 provides an economic evaluation on the cost effectiveness of the advanced reheat furnace concept. Section 6.0 concludes the report with recommendations on the applicability of the combined technologies of steel reheat furnaces.

  13. A CTSA agenda to advance methods for comparative effectiveness research.

    PubMed

    Helfand, Mark; Tunis, Sean; Whitlock, Evelyn P; Pauker, Stephen G; Basu, Anirban; Chilingerian, Jon; Harrell, Frank E; Meltzer, David O; Montori, Victor M; Shepard, Donald S; Kent, David M

    2011-06-01

    Clinical research needs to be more useful to patients, clinicians, and other decision makers. To meet this need, more research should focus on patient-centered outcomes, compare viable alternatives, and be responsive to individual patients' preferences, needs, pathobiology, settings, and values. These features, which make comparative effectiveness research (CER) fundamentally patient-centered, challenge researchers to adopt or develop methods that improve the timeliness, relevance, and practical application of clinical studies. In this paper, we describe 10 priority areas that address 3 critical needs for research on patient-centered outcomes (PCOR): (1) developing and testing trustworthy methods to identify and prioritize important questions for research; (2) improving the design, conduct, and analysis of clinical research studies; and (3) linking the process and outcomes of actual practice to priorities for research on patient-centered outcomes. We argue that the National Institutes of Health, through its clinical and translational research program, should accelerate the development and refinement of methods for CER by linking a program of methods research to the broader portfolio of large, prospective clinical and health system studies it supports. Insights generated by this work should be of enormous value to PCORI and to the broad range of organizations that will be funding and implementing CER.

  14. FY2011 Annual Progress Report for Advanced Combustion Engine Research and Development

    SciTech Connect

    none,

    2011-12-01

    Annual Progress Report for the Advanced Combustion Engine Research and Development (R&D) subprogram supporting the mission of the Vehicle Technologies Program by removing the critical technical barriers to commercialization of advanced internal combustion engines (ICEs) for passenger and commercial vehicles that meet future federal emissions regulations.

  15. Learning Design Research: Advancing Pedagogies in the Digital Age

    ERIC Educational Resources Information Center

    Dobozy, Eva

    2013-01-01

    Learning design research (LDR) is establishing itself as a separate and specialised field of educational research. Worldwide, technology-mediated learning experiences in higher and further education are on the increase. LDR investigates their success in providing effective outcomes-based and personalised learning experiences. This paper reports on…

  16. Research Advances: New Weapon in War on TB

    ERIC Educational Resources Information Center

    King, Angela G.

    2005-01-01

    Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis, which usually attacks the lung and is spread through the air from one person to another. Researchers from Johnson & Johnson Pharmaceutical Research and Development, the Swedish Institute for Infectious Disease Control and The Pitie-Salpetriere School of Medicine began their…

  17. Methodological Advances in Research on Learning and Instruction and in the Learning Sciences

    ERIC Educational Resources Information Center

    Fischer, Frank; Järvelä, Sanna

    2014-01-01

    Recent years have seen a dynamic growth of research communities addressing conditions, processes and outcomes of learning in formal and informal environments. Two of them have markedly advanced the field: The community on research on learning and instruction that has been organized in the European Association for Research on Learning and…

  18. Advanced Materials Research with 3RD Generation Synchrotron Light

    NASA Astrophysics Data System (ADS)

    Soukiassian, P.; D'angelo, M.; Enriquez, H.; Aristov, V. Yu.

    H and D surface nanochemistry on an advanced wide band gap semiconductor, silicon carbide is investigated by synchrotron radiation-based core level and valence band photoemission, infrared absorption and scanning tunneling spectroscopy, showing the 1st example of H/D-induced semiconductor surface metallization, that also occurs on a pre-oxidized surface. These results are compared to recent state-of-the-art ab-initio total energy calculations. Most interestingly, an amazing isotopic behavior is observed with a smaller charge transfer from D atoms suggesting the role of dynamical effects. Such findings are especially exciting in semiconductor physics and in interface with biology.

  19. Advanced Video Data-Acquisition System For Flight Research

    NASA Technical Reports Server (NTRS)

    Miller, Geoffrey; Richwine, David M.; Hass, Neal E.

    1996-01-01

    Advanced video data-acquisition system (AVDAS) developed to satisfy variety of requirements for in-flight video documentation. Requirements range from providing images for visualization of airflows around fighter airplanes at high angles of attack to obtaining safety-of-flight documentation. F/A-18 AVDAS takes advantage of very capable systems like NITE Hawk forward-looking infrared (FLIR) pod and recent video developments like miniature charge-couple-device (CCD) color video cameras and other flight-qualified video hardware.

  20. A Description of the Advanced Research WRF Version 2

    DTIC Science & Technology

    2005-06-01

    hydrostatic counterpart to the nonhydrostatic equations , (2.9) replaces the vertical momentum equation (2.5) and it becomes a constraint on the solution ...model equations as Φt = R(Φ), the RK3 integration takes the form of 3 steps to advance a solution Φ(t) to Φ(t+∆t): Φ∗ = Φt + ∆t 3 R(Φt) (3.1) Φ∗∗ = Φt...workshops, and lectures. (Distribution may be limited to attendees.) STR: Scientific and Technical Reports Data compilations, theoretical and numerical

  1. 78 FR 18933 - Proposed Priority-National Institute on Disability and Rehabilitation Research-Advanced...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF EDUCATION 34...--Advanced Rehabilitation Research Training Program AGENCY: Office of Special Education and Rehabilitative Services, Department of Education. ACTION: Proposed priority. SUMMARY: The Assistant Secretary for...

  2. Clinical Trial Results Vary Widely, But Always Advance Research | NIH MedlinePlus the Magazine

    MedlinePlus

    ... of this page please turn Javascript on. Feature: Clinical Trials Clinical Trial Results Vary Widely, But Always Advance Research ... very emotional." Should You Be Interested in a Clinical Trial People volunteer to take part in clinical ...

  3. Research on chemical vapor deposition processes for advanced ceramic coatings

    NASA Technical Reports Server (NTRS)

    Rosner, Daniel E.

    1993-01-01

    Our interdisciplinary background and fundamentally-oriented studies of the laws governing multi-component chemical vapor deposition (VD), particle deposition (PD), and their interactions, put the Yale University HTCRE Laboratory in a unique position to significantly advance the 'state-of-the-art' of chemical vapor deposition (CVD) R&D. With NASA-Lewis RC financial support, we initiated a program in March of 1988 that has led to the advances described in this report (Section 2) in predicting chemical vapor transport in high temperature systems relevant to the fabrication of refractory ceramic coatings for turbine engine components. This Final Report covers our principal results and activities for the total NASA grant of $190,000. over the 4.67 year period: 1 March 1988-1 November 1992. Since our methods and the technical details are contained in the publications listed (9 Abstracts are given as Appendices) our emphasis here is on broad conclusions/implications and administrative data, including personnel, talks, interactions with industry, and some known applications of our work.

  4. Exploring the promises of intersectionality for advancing women's health research

    PubMed Central

    2010-01-01

    Women's health research strives to make change. It seeks to produce knowledge that promotes action on the variety of factors that affect women's lives and their health. As part of this general movement, important strides have been made to raise awareness of the health effects of sex and gender. The resultant base of knowledge has been used to inform health research, policy, and practice. Increasingly, however, the need to pay better attention to the inequities among women that are caused by racism, colonialism, ethnocentrism, heterosexism, and able-bodism, is confronting feminist health researchers and activists. Researchers are seeking new conceptual frameworks that can transform the design of research to produce knowledge that captures how systems of discrimination or subordination overlap and "articulate" with one another. An emerging paradigm for women's health research is intersectionality. Intersectionality places an explicit focus on differences among groups and seeks to illuminate various interacting social factors that affect human lives, including social locations, health status, and quality of life. This paper will draw on recently emerging intersectionality research in the Canadian women's health context in order to explore the promises and practical challenges of the processes involved in applying an intersectionality paradigm. We begin with a brief overview of why the need for an intersectionality approach has emerged within the context of women's health research and introduce current thinking about how intersectionality can inform and transform health research more broadly. We then highlight novel Canadian research that is grappling with the challenges in addressing issues of difference and diversity. In the analysis of these examples, we focus on a largely uninvestigated aspect of intersectionality research - the challenges involved in the process of initiating and developing such projects and, in particular, the meaning and significance of social

  5. Exploring the promises of intersectionality for advancing women's health research.

    PubMed

    Hankivsky, Olena; Reid, Colleen; Cormier, Renee; Varcoe, Colleen; Clark, Natalie; Benoit, Cecilia; Brotman, Shari

    2010-02-11

    Women's health research strives to make change. It seeks to produce knowledge that promotes action on the variety of factors that affect women's lives and their health. As part of this general movement, important strides have been made to raise awareness of the health effects of sex and gender. The resultant base of knowledge has been used to inform health research, policy, and practice. Increasingly, however, the need to pay better attention to the inequities among women that are caused by racism, colonialism, ethnocentrism, heterosexism, and able-bodism, is confronting feminist health researchers and activists. Researchers are seeking new conceptual frameworks that can transform the design of research to produce knowledge that captures how systems of discrimination or subordination overlap and "articulate" with one another. An emerging paradigm for women's health research is intersectionality. Intersectionality places an explicit focus on differences among groups and seeks to illuminate various interacting social factors that affect human lives, including social locations, health status, and quality of life. This paper will draw on recently emerging intersectionality research in the Canadian women's health context in order to explore the promises and practical challenges of the processes involved in applying an intersectionality paradigm. We begin with a brief overview of why the need for an intersectionality approach has emerged within the context of women's health research and introduce current thinking about how intersectionality can inform and transform health research more broadly. We then highlight novel Canadian research that is grappling with the challenges in addressing issues of difference and diversity. In the analysis of these examples, we focus on a largely uninvestigated aspect of intersectionality research - the challenges involved in the process of initiating and developing such projects and, in particular, the meaning and significance of social

  6. Creep and fatigue research efforts on advanced materials

    NASA Technical Reports Server (NTRS)

    Gayda, John

    1990-01-01

    Two of the more important materials problems encountered in turbine blades of aircraft engines are creep and fatigue. To withstand these high-temperature phenomena, modern engines utilize single-crystal, nickel-base superalloys as the material of choice in critical applications. This paper will present recent research activities at NASA's Lewis Research Center on single-crystal blading material, related to creep and fatique. The goal of these research efforts is to improve the understanding of microstructure-property relationships and thereby guide material development.

  7. Creep and fatigue research efforts on advanced materials

    NASA Technical Reports Server (NTRS)

    Gayda, John

    1987-01-01

    Two of the more important materials problems encountered in turbine blades of aircraft engines are creep and fatigue. To withstand these high-temperature phenomena modern engines utilize single-crystal, nickel-based superalloys as the material of choice in critical applications. Recent research activities at Lewis on single-crystal blading material as well as future research initiatives on metal matrix composites related to creep and fatigue are discussed. The goal of these research efforts is improving the understanding of microstructure-property relationships and thereby guide material development.

  8. The Advanced Interdisciplinary Research Laboratory: A Student Team Approach to the Fourth-Year Research Thesis Project Experience

    ERIC Educational Resources Information Center

    Piunno, Paul A. E.; Boyd, Cleo; Barzda, Virginijus; Gradinaru, Claudiu C.; Krull, Ulrich J.; Stefanovic, Sasa; Stewart, Bryan

    2014-01-01

    The advanced interdisciplinary research laboratory (AIRLab) represents a novel, effective, and motivational course designed from the interdisciplinary research interests of chemistry, physics, biology, and education development faculty members as an alternative to the independent thesis project experience. Student teams are assembled to work…

  9. Fish Protection: Cooperative research advances fish-friendly turbine design

    SciTech Connect

    Brown, Richard S.; Ahmann, Martin L.; Trumbo, Bradly A.; Foust, Jason

    2012-12-01

    Renewable hydropower is a tremendous resource within the Pacific Northwest that is managed with considerable cost and consideration for the safe migration of salmon. Recent research conducted in this region has provided results that could lower the impacts of hydro power production and make the technology more fish-friendly. This research is now being applied during a period when a huge emphasis is being made to develop clean, renewable energy sources.

  10. Advancing Aeronautics: A Decision Framework for Selecting Research Agendas

    DTIC Science & Technology

    2011-01-01

    p. cm. Includes bibliographical references. ISBN 978-0-8330-5019-9 (pbk. : alk. paper) 1. Aeronautics—Research-- Government policy—United...from current research and new ideas, not a strategic vision of the greatest challenges, govern - mental role, social needs, potential payoffs, economic...Navy, the Marine Corps, the U.S. Coast Guard, the U.S. Intel- ligence Community, allied foreign governments , and foundations. For more information on

  11. Highlights of the Latest Advances in Research on CDK Inhibitors.

    PubMed

    Cicenas, Jonas; Kalyan, Karthik; Sorokinas, Aleksandras; Jatulyte, Asta; Valiunas, Deividas; Kaupinis, Algirdas; Valius, Mindaugas

    2014-10-27

    Uncontrolled proliferation is the hallmark of cancer and other proliferative disorders and abnormal cell cycle regulation is, therefore, common in these diseases. Cyclin-dependent kinases (CDKs) play a crucial role in the control of the cell cycle and proliferation. These kinases are frequently deregulated in various cancers, viral infections, neurodegenerative diseases, ischemia and some proliferative disorders. This led to a rigorous pursuit for small-molecule CDK inhibitors for therapeutic uses. Early efforts to block CDKs with nonselective CDK inhibitors led to little specificity and efficacy but apparent toxicity, but the recent advance of selective CDK inhibitors allowed the first successful efforts to target these kinases for the therapies of several diseases. Major ongoing efforts are to develop CDK inhibitors as monotherapies and rational combinations with chemotherapy and other targeted drugs.

  12. Gas-turbine critical research and advanced technology support project

    NASA Technical Reports Server (NTRS)

    Clark, J. S.; Hodge, P. E.; Lowell, C. E.; Anderson, D. N.; Schultz, D. F.

    1981-01-01

    A technology data base for utility gas turbine systems capable of burning coal derived fuels was developed. The following areas are investigated: combustion; materials; and system studies. A two stage test rig is designed to study the conversion of fuel bound nitrogen to NOx. The feasibility of using heavy fuels in catalytic combustors is evaluated. A statistically designed series of hot corrosion burner rig tests was conducted to measure the corrosion rates of typical gas turbine alloys with several fuel contaminants. Fuel additives and several advanced thermal barrier coatings are tested. Thermal barrier coatings used in conjunction with low critical alloys and those used in a combined cycle system in which the stack temperature was maintained above the acid corrosion temperature are also studied.

  13. Recent advances in the use of gelatin in biomedical research.

    PubMed

    Su, Kai; Wang, Chunming

    2015-11-01

    The biomacromolecule, gelatin, has increasingly been used in biomedicine-beyond its traditional use in food and cosmetics. The appealing advantages of gelatin, such as its cell-adhesive structure, low cost, off-the-shelf availability, high biocompatibility, biodegradability and low immunogenicity, among others, have made it a desirable candidate for the development of biomaterials for tissue engineering and drug delivery. Gelatin can be formulated in the form of nanoparticles, employed as size-controllable porogen, adopted as surface coating agent and mixed with synthetic or natural biopolymers forming composite scaffolds. In this article, we review recent advances in the versatile applications of gelatin within biomedical context and attempt to draw upon its advantages and potential challenges.

  14. A conceptual design of main components sizing for UMT PHEV powertrain

    NASA Astrophysics Data System (ADS)

    Haezah, M. N.; Norbakyah, J. S.; Atiq, W. H.; Salisa, A. R.

    2015-12-01

    This paper presents a conceptual design of main components sizing for Universiti Malaysia Terengganu plug-in hybrid electric vehicle (UMT PHEV) powertrain. In the design of hybrid vehicles, it is important to identify a proper component sizes. Component sizing significantly affects vehicle performance, fuel economy and emissions. The proposed UMT PHEV has only one electric machine (EM) which functions as either a motor or generator at a time and using batteries and ultracapacitors as an energy storage system (ESS). In this work, firstly, energy and power requirements based on parameters, specifications and performance requirements of vehicle are calculated. Then, the parameters for internal combustion engine, EM and ESS are selected based on the developed Kuala Terengganu drive cycle. The results obtained from this analysis are within reasonable range and satisfactory.

  15. Extremal harmonic active control of power for a monocylinder hybrid powertrain

    NASA Astrophysics Data System (ADS)

    Gauthier, Jean-Philippe; Micheau, Philippe; Cauet, Sébastien; Coirault, Patrick; Martin, Pascal

    2011-11-01

    This article presents a real-life application for the extremal harmonic active control of power [1] applied on a hybrid engine setup. The active control was adapted for a hybrid powertrain constituted of a one-cylinder diesel engine coupled with a permanent magnet synchronous machine. The problem was formulated in the harmonic domain and the control objective was to extremalize energetic criterions. Three criterions were considered: minimizing the speed ripple of the engine, maximizing the mechanical reactive power (mechanical impedance adaptation) and maximizing the active electric power for energy harvesting. The results show that, for the first and second orders of the ripple, speed oscillations can be completely cancelled and reactive power and active power can be optimized on-line. The implicit extremal controller converged rapidly, remaining stable even when the mean engine speed changed abruptly. These results confirm the robustness and the applicability of the extremal harmonic active control for industrial applications.

  16. Cooperative Research and Development for Advanced Microturbines Program on Advanced Integrated Microturbine System

    SciTech Connect

    Michael J. Bowman

    2007-05-30

    The Advanced Integrated Microturbine Systems (AIMS) project was kicked off in October of 2000 to develop the next generation microturbine system. The overall objective of the project was to develop a design for a 40% electrical efficiency microturbine system and demonstrate many of the enabling technologies. The project was initiated as a collaborative effort between several units of GE, Elliott Energy Systems, Turbo Genset, Oak Ridge National Lab and Kyocera. Since the inception of the project the partners have changed but the overall direction of the project has stayed consistent. The project began as a systems study to identify design options to achieve the ultimate goal of 40% electrical efficiency. Once the optimized analytical design was identified for the 40% system, it was determined that a 35% efficient machine would be capable of demonstrating many of the advanced technologies within the given budget and timeframe. The items that would not be experimentally demonstrated were fully produced ceramic parts. However, to understand the requirements of these ceramics, an effort was included in the project to experimentally evaluate candidate materials in representative conditions. The results from this effort would clearly identify the challenges and improvement required of these materials for the full design. Following the analytical effort, the project was dedicated to component development and testing. Each component and subsystem was designed with the overall system requirements in mind and each tested to the fullest extent possible prior to being integrated together. This method of component development and evaluation helps to minimize the technical risk of the project. Once all of the components were completed, they were assembled into the full system and experimentally evaluated.

  17. Eco-informatics for decision makers advancing a research agenda

    USGS Publications Warehouse

    Cushing, J.B.; Wilson, T.; Brandt, L.; Gregg, V.; Spengler, S.; Borning, A.; Delcambre, L.; Bowker, G.; Frame, M.; Fulop, J.; Hert, C.; Hovy, E.; Jones, J.; Landis, E.; Schnase, J.L.; Schweik, C.; Sonntag, W.; ,

    2005-01-01

    Resource managers often face significant information technology (IT) problems when integrating ecological or environmental information to make decisions. At a workshop sponsored by the NSF and USGS in December 2004, university researchers, natural resource managers, and information managers met to articulate IT problems facing ecology and environmental decision makers. Decision making IT problems were identified in five areas: 1) policy, 2) data presentation, 3) data gaps, 4) tools, and 5) indicators. To alleviate those problems, workshop participants recommended specific informatics research in modeling and simulation, data quality, information integration and ontologies, and social and human aspects. This paper reports the workshop findings, and briefly compares these with research that traditionally falls under the emerging eco-informatics rubric. ?? Springer-Verlag Berlin Heidelberg 2005.

  18. Advancing Australia's role in climate change and health research

    NASA Astrophysics Data System (ADS)

    Green, Donna; Pitman, Andrew; Barnett, Adrian; Kaldor, John; Doherty, Peter; Stanley, Fiona

    2017-02-01

    A major Australian government report published 25 years ago called for urgent investment in research on the impacts of climate change on human health. Since that report's release, less than 0.1% of Australian health funding has been allocated to this area. As the world continues on a high emissions pathway, the health impacts from climate change are increasing in size and complexity. While Australia has established leadership roles in climate science and health research, it must now link these two strengths. Doing so would boost regional understanding of how climate change will affect health and what adaptation strategies are needed to reduce these threats. Such research would support better health planning and decision-making in partnership with other regional countries.

  19. Research in advanced formal theorem-proving techniques

    NASA Technical Reports Server (NTRS)

    Rulifson, J. F.

    1971-01-01

    The present status is summarized of a continuing research program aimed at the design and implementation of a language for expressing problem-solving procedures in several areas of artificial intelligence, including program synthesis, robot planning, and theorem proving. Notations, concepts, and procedures common to the representation and solution of many of these problems were abstracted and incorporated as features into the language. The areas of research covered are described, and abstracts of six papers that contain extensive description and technical detail of the work are presented.

  20. Public-private partnerships advance contraceptive research and development.

    PubMed

    Harper, Michael J K

    2008-10-01

    The concept of public-private partnerships as a way to tackle global health problems is discussed. It is noted that surveys of such partnerships have not included contraception and contraceptive research and development (R&D), since pregnancy is not regarded as a disease. Nevertheless, there has been an attempt to apply the concept to improve maternal health through establishment of the Consortium for Industrial Collaboration in Contraceptive Research (CICCR) and its involvement with the AMPPA projects. The outcome of the CICCR initiative is discussed. Actions for the future are outlined.

  1. UPDATE ON DEVELOPMENT OF NUDGING FDDA FOR ADVANCED RESEARCH WRF

    EPA Science Inventory

    A nudging-based four-dimensional data assimilation (FDDA) system is being developed for the Weather Research and Forecasting (WRF) Model. This effort represents a collaboration between The Pennsylvania State University (i.e., Penn State), the National Center for Atmospheric Rese...

  2. Transportation and Aging: A Research Agenda for Advancing Safe Mobility

    ERIC Educational Resources Information Center

    Dickerson, Anne E.; Molnar, Lisa J.; Eby, David W.; Adler, Geri; Bedard, Michel; Berg-Weger, Marla; Classen, Sherrilene; Foley, Daniel; Horowitz, Amy; Kerschner, Helen; Page, Oliver; Silverstein, Nina M.; Staplin, Loren; Trujillo, Leonard

    2007-01-01

    Purpose: We review what we currently know about older driver safety and mobility, and we highlight important research needs in a number of key areas that hold promise for achieving the safety and mobility goals for the aging baby boomers and future generations of older drivers. Design and Methods: Through the use of a framework for transportation…

  3. ADVANCED COMPOSITES TECHNOLOGY CASE STUDY AT NASA LANGLEY RESEARCH CENTER

    EPA Science Inventory

    This report summarizes work conducted at the National Aeronautics and Space Administration's Langley Research Center (NASA-LaRC) in Hampton, VA, under the U.S. Environmental Protection Agency’s (EPA) Waste Reduction Evaluations at Federal Sites (WREAFS) Program. Support for...

  4. Can the SBIR and STTR programs advance research goals?

    PubMed

    Ceulemans, Steven; Kolls, Jay K

    2013-03-01

    With diminishing grant support for traditional funding in immunology, can the small-business program leverage a research program? The small-business grants programs offered by the US National Institutes of Health and other organizations support high-risk, early-stage technology commercialization at small businesses.

  5. Advanced aerodynamics and active controls. Selected NASA research

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Aerodynamic and active control concepts for application to commercial transport aircraft are discussed. Selected topics include in flight direct strike lightning research, triply redundant digital fly by wire control systems, tail configurations, winglets, and the drones for aerodynamic and structural testing (DAST) program.

  6. Advanced Quantitative Measurement Methodology in Physics Education Research

    ERIC Educational Resources Information Center

    Wang, Jing

    2009-01-01

    The ultimate goal of physics education research (PER) is to develop a theoretical framework to understand and improve the learning process. In this journey of discovery, assessment serves as our headlamp and alpenstock. It sometimes detects signals in student mental structures, and sometimes presents the difference between expert understanding and…

  7. Advancing Methods for U.S. Transgender Health Research

    PubMed Central

    Reisner, Sari L.; Deutsch, Madeline B.; Bhasin, Shalender; Bockting, Walter; Brown, George R.; Feldman, Jamie; Garofalo, Rob; Kreukels, Baudewijntje; Radix, Asa; Safer, Joshua D.; Tangpricha, Vin; T’Sjoen, Guy; Goodman, Michael

    2016-01-01

    Purpose of Review To describe methodological challenges, gaps, and opportunities in U.S. transgender health research. Recent Findings Lack of large prospective observational studies and intervention trials, limited data on risks and benefits of gender affirmation (e.g., hormones and surgical interventions), and inconsistent use of definitions across studies hinder evidence-based care for transgender people. Systematic high-quality observational and intervention-testing studies may be carried out using several approaches, including general population-based, health systems-based, clinic-based, venue-based, and hybrid designs. Each of these approaches has its strength and limitations; however, harmonization of research efforts is needed. Ongoing development of evidence-based clinical recommendations will benefit from a series of observational and intervention studies aimed at identification, recruitment, and follow-up of transgender people of different ages, from different racial, ethnic, and socioeconomic backgrounds and with diverse gender identities. Summary Transgender health research faces challenges that include standardization of lexicon, agreed-upon population definitions, study design, sampling, measurement, outcome ascertainment, and sample size. Application of existing and new methods is needed to fill existing gaps, increase the scientific rigor and reach of transgender health research, and inform evidence-based prevention and care for this underserved population. PMID:26845331

  8. Parent-Child Play across Cultures: Advancing Play Research

    ERIC Educational Resources Information Center

    Roopnarine, Jaipaul L.; Davidson, Kimberly L.

    2015-01-01

    In this article, the authors argue for a greater understanding of children's play across cultures through better integration of scientific thinking about the developed and developing societies, through consideration of socialization beliefs and goals, and, finally, through the use of more complex models in research investigations. They draw on…

  9. Advancing Massage Therapy Research Competencies: Dimensions for Thought and Action.

    ERIC Educational Resources Information Center

    Hymel, Glenn M.

    Two major developments in the therapeutic massage and bodywork profession have recently brought to the forefront the issue of research competencies. The profession has been called to a potentially heightened level of credibility. One challenge to the profession's development is that of coordinating the various curricular, instructional,…

  10. Battling Fatigue in Aviation: Recent Advancements in Research and Practice

    DTIC Science & Technology

    2012-01-01

    deprivation. Results from research using positron emission tomography (PET) indicated that introverts typically demonstrate greater cortical arousal than do...subjects demonstrated greater performance impairment than did introverted subjects. Rupp, Killgore, and Balkin38 extended these fi ndings in a study to...socially-impoverished environment. In contrast, variations in social environment did not affect the response of introverts . The authors concluded that

  11. Advances in soil erosion research: processes, measurement, and modeling

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Soil erosion by the environmental agents of water and wind is a continuing global menace that threatens the agricultural base that sustains our civilization. Members of ASABE have been at the forefront of research to understand erosion processes, measure erosion and related processes, and model very...

  12. Bio-based wood adhesives research: Advances and outlooks

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In the past three decades, concerns related to the environment and human health risks and interests in resources recycling and sustainability have propelled the resurgence of the research on bio-based adhesives, especially those based on agricultural and forest products and byproducts. In this concl...

  13. The Impact of Research and Technological Advances on Dental Education.

    ERIC Educational Resources Information Center

    Loe, Harald

    1981-01-01

    To arrive at a learning situation conducive to a scientific approach in dental school teaching of diagnosis, treatment, prescription, and judgment of prognosis, it is necessary to strengthen the scientific environment in dental schools, increase scientifically trained faculty, and guarantee student involvement in research. (MLW)

  14. 1973 Advances in Socio-Dental Research. Vol. 1.

    ERIC Educational Resources Information Center

    Goetz, John B., Ed.

    This publication is a collection of abstracts from volumes 6 and 7 (1971 and 1972) of "Oral Research Abstracts," selected because the abstracts contain information relating one of the social sciences with dentistry. The compilation is intended to be useful to epidemiologists, public health workers, and all those who have an interest in…

  15. [Advances in researches of molluscicidal microorganisms against Oncomelania hupensis].

    PubMed

    Cheng, Wan-ting; Zhou, Yi-biao; Pan, Xiang; Song, Xiu-xia; Jiang, Qing-wu

    2016-02-01

    The elimination of Oncomelania hupensis snails is important to schistosomiasis control. Recently, the application of molluscicidal organisms is considered as a safe and efficient method for snail elimination. In order to provide scientific evidences for effective control of O. hupensis and schistosomiasis, this paper summarizes the researches of molluscicidal microorganisms against O. hupensis.

  16. Translating Advances in Reading Comprehension Research to Educational Practice

    ERIC Educational Resources Information Center

    McNamara, Danielle S.; Kendeou, Panayiota

    2011-01-01

    The authors review five major findings in reading comprehension and their implications for educational practice. First, research suggests that comprehension skills are separable from decoding processes and important at early ages, suggesting that comprehension skills should be targeted early, even before the child learns to read. Second, there is…

  17. Advancement Services: Research and Technology Support for Fund Raising.

    ERIC Educational Resources Information Center

    Taylor, John H., Ed.

    This book is intended for individuals who work in the operations side of campus fundraising, and addresses such issues as accounting and Internal Revenue Services rules and regulations, new technologies, gift processing, and prospect tracking and management. The 21 chapters are organized around five topics: prospect research, gift processing,…

  18. Aviation System Technology Advanced Research Program - AvSTAR

    NASA Technical Reports Server (NTRS)

    Denery, Dallas G.

    2001-01-01

    The objectives of this presentation is to provide the research and development by 2007 necessary to: complete the development of technology for tomorrow (Free-Flight); provide the foundations for setting the direction for the future (Beyond Free-Flight). The goals are to establish tomorrow's as well as the future's Air transportation system.

  19. [Research advances in eco-toxicological diagnosis of soil pollution].

    PubMed

    Liu, Feng; Teng, Hong-Hui; Ren, Bai-Xiang; Shi, Shu-Yun

    2014-09-01

    Soil eco-toxicology provides a theoretical basis for ecological risk assessment of contaminated soils and soil pollution control. Research on eco-toxicological effects and molecular mechanisms of toxic substances in soil environment is the central content of the soil eco-toxicology. Eco-toxicological diagnosis not only gathers all the information of soil pollution, but also provides the overall toxic effects of soil. Therefore, research on the eco-toxicological diagnosis of soil pollution has important theoretical and practical significance. Based on the research of eco-toxicological diagnosis of soil pollution, this paper introduced some common toxicological methods and indicators, with the advantages and disadvantages of various methods discussed. However, conventional biomarkers can only indicate the class of stress, but fail to explain the molecular mechanism of damage or response happened. Biomarkers and molecular diagnostic techniques, which are used to evaluate toxicity of contaminated soil, can explore deeply detoxification mechanisms of organisms under exogenous stress. In this paper, these biomarkers and techniques were introduced systematically, and the future research trends were prospected.

  20. Advanced Gas Turbine (AGT) technology development project

    NASA Technical Reports Server (NTRS)

    1987-01-01

    This report is the final in a series of Technical Summary Reports for the Advanced Gas Turbine (AGT) Technology Development Project, authorizrd under NASA Contract DEN3-167 and sponsored by the DOE. The project was administered by NASA-Lewis Research Center of Cleveland, Ohio. Plans and progress are summarized for the period October 1979 through June 1987. This program aims to provide the US automotive industry the high risk, long range technology necessary to produce gas turbine engines for automobiles that will reduce fuel consumption and reduce environmental impact. The intent is that this technology will reach the marketplace by the 1990s. The Garrett/Ford automotive AGT was designated AGT101. The AGT101 is a 74.5 kW (100 shp) engine, capable of speeds to 100,000 rpm, and operates at turbine inlet temperatures to 1370 C (2500 F) with a specific fuel consumption level of 0.18 kg/kW-hr (0.3 lbs/hp-hr) over most of the operating range. This final report summarizes the powertrain design, power section development and component/ceramic technology development.

  1. Recent advances in primary palate and midface morphogenesis research.

    PubMed

    Diewert, V M; Wang, K Y

    1992-01-01

    During the sixth week of human development, the primary palate develops as facial prominences enlarge around the nasal pits to form the premaxillary region. Growth of craniofacial components changes facial morphology and affects the extent of contact between the facial prominences. Our recent studies have focused on developing methods to analyze growth of the primary palate and the craniofacial complex to define morphological phases of normal development and to determine alterations leading to cleft lip malformation. Analysis of human embryos in the Carnegie Embryology Collection and mouse embryos of cleft lip and noncleft strains showed that human and mouse embryos have similar phases of primary palate development: first, an epithelial seam, the nasal fin, forms; then a mesenchymal bridge develops through the nasal fin and enlarges rapidly. A robust mesenchymal bridge must form between the facial prominences before advancing midfacial growth patterns tend to separate the facial components as the medial nasal region narrows and elongates, the nasal pits narrow, and the primary choanae (posterior nares) open posterior to the primary palate. In mouse strains with cleft lip gene, maxillary growth, nasal fin formation, and mesenchymal replacement of the nasal fin were all delayed compared with noncleft strains of mice. Successful primary palate formation involves a sequence of local cellular events that are closely timed with spatial changes associated with craniofacial growth that must occur within a critical developmental period.

  2. Recent advances in the research of lymphatic stomata.

    PubMed

    Wang, Zi-Bin; Li, Meng; Li, Ji-Cheng

    2010-05-01

    Lymphatic stomata are small openings of lymphatic capillaries on the free surface of the mesothelium. The peritoneal cavity, pleural cavity, and pericardial cavity are connected with lymphatic system via these small openings, which have the function of active absorption. The ultrastructure of the lymphatic stomata and their absorption from the body cavities are important clinically, such as ascites elimination, neoplasm metastasis, and inflammatory reaction. The lymphatic stomata play an important role in the physiological and pathological conditions. Our previous study indicated for the first time that nitric oxide (NO) could regulate the opening and absorption of the lymphatic stomata. It could decrease the level of free intracellular calcium [Ca(2+)] through increasing the cyclic guanosine monophosphate (cGMP) level in the rat peritoneal mesothelial cells, thus regulating the lymphatic stomata. This process is related with the NO-cGMP-[Ca(2+)] signal pathway. In this review, we summarize the recent advances in understanding the development and the function of the lymphatic stomata. The ultrastructure and regulations of the lymphatic stomata are also discussed in this review.

  3. Critical research and advanced technology (CRT) support project

    NASA Technical Reports Server (NTRS)

    Furman, E. R.; Anderson, D. N.; Hodge, P. E.; Lowell, C. E.; Nainiger, J. J.; Schultz, D. F.

    1983-01-01

    A critical technology base for utility and industrial gas turbines by planning the use of coal-derived fuels was studied. Development tasks were included in the following areas: (1) Combustion - investigate the combustion of coal-derived fuels and methods to minimize the conversion of fuel-bound nitrogen to NOx; (2) materials - understand and minimize hot corrosion; (3) system studies - integrate and focus the technological efforts. A literature survey of coal-derived fuels was completed and a NOx emissions model was developed. Flametube tests of a two-stage (rich-lean) combustor defined optimum equivalence ratios for minimizing NOx emissions. Sector combustor tests demonstrated variable air control to optimize equivalence ratios over a wide load range and steam cooling of the primary zone liner. The catalytic combustion of coal-derived fuels was demonstrated. The combustion of coal-derived gases is very promising. A hot-corrosion life prediction model was formulated and verified with laboratory testing of doped fuels. Fuel additives to control sulfur corrosion were studied. The intermittent application of barium proved effective. Advanced thermal barrier coatings were developed and tested. Coating failure modes were identified and new material formulations and fabrication parameters were specified. System studies in support of the thermal barrier coating development were accomplished.

  4. Advanced technology options for industrial heating equipment research

    SciTech Connect

    Jain, R.C.

    1992-10-01

    This document presents a strategy for a comprehensive program plan that is applicable to the Combustion Equipment Program of the DOE Office of Industrial Technologies (the program). The program seeks to develop improved heating equipment and advanced control techniques which, by improvements in combustion and beat transfer, will increase energy-use efficiency and productivity in industrial processes and allow the preferred use of abundant, low grade and waste domestic fuels. While the plan development strategy endeavors to be consistent with the programmatic goals and policies of the office, it is primarily governed by the needs and concerns of the US heating equipment industry. The program, by nature, focuses on energy intensive industrial processes. According to the DOE Manufacturing Energy Consumption Survey (MECS), the industrial sector in the US consumed about 21 quads of energy in 1988 in the form of coal, petroleum, natural gas and electricity. This energy was used as fuels for industrial boilers and furnaces, for agricultural uses, for construction, as feedstocks for chemicals and plastics, and for steel, mining, motors, engines and other industrial use over 75 percent of this energy was consumed to provide heat and power for manufacturing industries. The largest consumers of fuel energy were the primary metals, chemical and allied products, paper and allied products, and stone, clay and glass industry groups which accounted for about 60% of the total fuel energy consumed by the US manufacturing sector.

  5. Gas turbine critical research and advanced technology (CRT) support project

    NASA Technical Reports Server (NTRS)

    Furman, E. R.; Anderson, D. N.; Gedwill, M. A.; Lowell, C. E.; Schultz, D. F.

    1982-01-01

    The technical progress to provide a critical technology base for utility gas turbine systems capable of burning coal-derived fuels is summarized. Project tasks include the following: (1) combustion - to investigate the combustion of coal-derived fuels and the conversion of fuel-bound nitrogen to NOx; (2) materials - to understand and prevent the hot corrosion of turbine hot section materials; and (3) system studies - to integrate and guide the technological efforts. Technical accomplishments include: an extension of flame tube combustion testing of propane - Toluene Fuel Mixtures to vary H2 content from 9 to 18 percent by weight and the comparison of results with that predicted from a NASA Lewis General Chemical Kinetics Computer Code; the design and fabrication of combustor sector test section to test current and advanced combustor concepts; Testing of Catalytic combustors with residual and coal-derived liquid fuels; testing of high strength super alloys to evaluate their resistance to potential fuel impurities using doped clean fuels and coal-derived liquids; and the testing and evaluation of thermal barrier coatings and bond coatings on conventional turbine materials.

  6. [Research advances in simulating land water-carbon coupling].

    PubMed

    Liu, Ning; Sun, Peng-Sen; Liu, Shi-Rong

    2012-11-01

    The increasing demand of adaptive management of land, forest, and water resources under the background of global change and water resources crisis has promoted the comprehensive study of coupling ecosystem water and carbon cycles and their restrictive relations. To construct the water-carbon coupling model and to approach the ecosystem water-carbon balance and its interactive response mechanisms under climate change at multiple spatiotemporal scales is nowadays a major concern. After reviewing the coupling relationships of water and carbon at various scales, this paper explored the implications and estimation methods of the key processes and related parameters of water-carbon coupling, the construction of evapotranspiration model at large scale based on RS, and the importance of this model in water-carbon coupling researches. The applications of assimilative multivariate data in water-carbon coupling researches under future climate change scenarios were also prospected.

  7. Advanced physical-chemical life support systems research

    NASA Technical Reports Server (NTRS)

    Evanich, Peggy L.

    1988-01-01

    A proposed NASA space research and technology development program will provide adequate data for designing closed loop life support systems for long-duration manned space missions. This program, referred to as the Pathfinder Physical-Chemical Closed Loop Life Support Program, is to identify and develop critical chemical engineering technologies for the closure of air and water loops within the spacecraft, surface habitats or mobility devices. Computerized simulation can be used both as a research and management tool. Validated models will guide the selection of the best known applicable processes and in the development of new processes. For the integration of the habitat system, a biological subsystem would be introduced to provide food production and to enhance the physical-chemical life support functions on an ever-increasing basis.

  8. Physical Chemistry Research Toward Proton Exchange Membrane Fuel Cell Advancement.

    PubMed

    Swider-Lyons, Karen E; Campbell, Stephen A

    2013-02-07

    Hydrogen fuel cells, the most common type of which are proton exchange membrane fuel cells (PEMFCs), are on a rapid path to commercialization. We credit physical chemistry research in oxygen reduction electrocatalysis and theory with significant breakthroughs, enabling more cost-effective fuel cells. However, most of the physical chemistry has been restricted to studies of platinum and related alloys. More work is needed to better understand electrocatalysts generally in terms of properties and characterization. While the advent of such highly active catalysts will enable smaller, less expensive, and more powerful stacks, they will require better understanding and a complete restructuring of the diffusion media in PEMFCs to facilitate faster transport of the reactants (O2) and products (H2O). Even Ohmic losses between materials become more important at high power. Such lessons from PEMFC research are relevant to other electrochemical conversion systems, including Li-air batteries and flow batteries.

  9. [Advances in research on biosynthesis of plant amylopectin].

    PubMed

    Gao, Zhen-Yu; Huang, Da-Nian; Qian, Qian

    2004-10-01

    Amylopectin, accounting for 70%-80% of storage starch, is one of the key components for quality of fruits and seeds in plant. Research on biosynthetic pathway of plant amylopectin holds great promise for modifying the structural composition of amylopectin and being used in food industry. The structure of plant amylopectin is summarized in this review and three types of amylopectin synthetase: starch branching enzyme (SBE), soluble starch synthase (SSS) and starch debranching enzyme (SDBE), which have become hotspots for research now, are expatiated in terms of genetics, enzymology and function. A model for the synthesis of amylopectin, "two-step branching and improper branch clearing model" is discussed. Problems in plant amylopectin biosynthesis and prospects for its application are also presented.

  10. Experimental Research in Advanced Concepts for Novel Reactive Materials

    DTIC Science & Technology

    2013-04-01

    Sand casting with pre-cast heating of tungsten elements  Induction casting with applied pressure II.A.2.a Experimental Furnace Casting The...such an experiment was completed during the research period. These experiments involved the electronic spectrum in the vacuum ultraviolet of the...methods used to create the casings include the following, each of which is outlined below:  Experimental casting in a small furnace  Sand casting

  11. [Research advances in soil nitrogen cycling models and their simulation].

    PubMed

    Tang, Guoyong; Huang, Daoyou; Tong, Chengli; Zhang, Wenju; Wu, Jinshui

    2005-11-01

    Nitrogen is one of the necessary nutrients for plant, and also a primary element leading to environmental pollution. Many researches have been concerned about the contribution of agricultural activities to environmental pollution by nitrogenous compounds, and the focus is how to simulate soil nitrogen cycling processes correctly. In this paper, the primary soil nitrogen cycling processes were reviewed in brief, with 13 cycling models and 6 simulated cycling processes introduced, and the parameterization of models discussed.

  12. [Research advances on medical genetics in China in 2015].

    PubMed

    Li, Yuanfeng; Han, Yubo; Cao, Pengbo; Meng, Jinfeng; Li, Haibei; Qin, Geng; Zhang, Feng; Jin, Guangfu; Yang, Yong; Wu, Lingqian; Ping, Jie; Zhou, Gangqiao

    2016-05-01

    Steady progress has been achieved in the medical genetics in China in 2015, as numerous original researches were published in the world's leading journals. Chinese scientists have made significant contributions to various fields of medical genetics, such as pathogenicity of rare diseases, predisposition of common diseases, somatic mutations of cancer, new technologies and methods, disease-related microRNAs (miRNAs), disease-related long non-coding RNAs (lncRNAs), disease-related competing endogenous RNAs (ceRNAs), disease-related RNA splicing and molecular evolution. In these fields, Chinese scientists have gradually formed the tendency, from common variants to rare variants, from single omic analyses to multipleomics integration analyses, from genetic discovery to functional confirmation, from basic research to clinical application. Meanwhile, the findings of Chinese scientists have been drawn great attentions of international peers. This review aims to provide an overall picture of the front in Chinese medical genetics, and highlights the important findings and their research strategy.

  13. Implementing common data elements across studies to advance research.

    PubMed

    Cohen, Marlene Z; Thompson, Cheryl Bagley; Yates, Bernice; Zimmerman, Lani; Pullen, Carol H

    2015-01-01

    Challenges arise in building the knowledge needed for evidence-based practice partially because obtaining clinical research data is expensive and complicated, and many studies have small sample sizes. Combining data from several studies may have the advantage of increasing the impact of the findings or expanding the population to which findings may be generalized. The use of common data elements will allow this combining and, in turn, create big data, which is an important approach that may accelerate knowledge development. This article discusses the philosophy of using common data elements across research studies and illustrates their use by the processes in a developmental center grant funded by the National Institutes of Health. The researchers identified a set of data elements and used them across several pilot studies. Issues that need to be considered in the adoption and implementation of common data elements across pilot studies include theoretical framework, purpose of the common measures, respondent burden, teamwork, managing large data sets, grant writing, and unintended consequences. We describe these challenges and solutions that can be implemented to manage them.

  14. Harmonization: a methodology for advancing research in multiple sclerosis.

    PubMed

    Magalhaes, S; Wolfson, C

    2012-01-01

    Decreasing research funding is in conflict with the increasing need to conduct large studies to examine rare risk factors and interactions between risk factors. As a result, investigators are searching for strategies to stretch research funds and to design studies that will maximize investments already made. Multiple sclerosis (MS) is generally accepted as a multifactorial disease, and the assessment of interactions between risk factors and the desire to assess risk factors within particular sub-groups requires a large number of participants. Harmonization is a methodology that may help address this problem. Harmonization is a methodological approach that aims to systematize the process of combining individual data that are collected in several observational studies. Combining data will increase sample size, but the quality of the harmonized result is only as high as the quality of the individual studies and the comparability of the constructs measured. In this short report, we introduce the concept of harmonization and provide examples where harmonization may be advantageous in MS research.

  15. Advancing landscape change research through the incorporation of Inupiaq knowledge

    USGS Publications Warehouse

    Eisner, Wendy R.; Cuomo, Chris J.; Hinkel, Kenneth M.; Jones, Benjamin M.; Brower, Ronald H.

    2009-01-01

    Indigenous knowledge is a valuable but under-used source of information relevant to landscape change research. We interviewed Iñupiat elders, hunters, and other knowledge-holders in the villages of Barrow and Atqasuk on the western Arctic Coastal Plain of northern Alaska to gain further insight into the processes governing the ubiquitous lakes and the dynamics of landscape change in this region of continuous permafrost. The interviews provided a suite of information related to lakes and associated drained lake basins, as well as knowledge on landforms, environmental change, human events, and other phenomena. We were able to corroborate many observations independently and verify the timing of several large and significant lake drainage events using either aerial photography or remotely sensed time series. Data collected have been incorporated into a geodatabase to develop a multi-layer Geographic Information System that will be useful for local and scientific communities. This research demonstrates that indigenous knowledge can reveal a new understanding of landscape changes on the Arctic Coastal Plain in general and on lake processes in particular. We advocate ongoing, community-oriented research throughout the Arctic as a means of assessing and responding to the consequences of rapid environmental change.

  16. Advances in Materials Research: An Internship at Kennedy Space Center

    NASA Technical Reports Server (NTRS)

    Barrios, Elizabeth A.; Roberson, Luke B.

    2011-01-01

    My time at Kennedy Space Center. was spent immersing myself in research performed in the Materials Science Division of the Engineering Directorate. My Chemical Engineering background provided me the ability to assist in many different projects ranging from tensile testing of composite materials to making tape via an extrusion process. However, I spent the majority of my time on the following three projects: (1) testing three different materials to determine antimicrobial properties; (2) fabricating and analyzing hydrogen sensing tapes that were placed at the launch pad for STS-133 launch; and (3) researching molten regolith electrolysis at KSC to prepare me for my summer internship at MSFC on a closely related topic. This paper aims to explain, in detail, what I have learned about these three main projects. It will explain why this research is happening and what we are currently doing to resolve the issues. This paper will also explain how the hard work and experiences that I have gained as an intern have provided me with the next big step towards my career at NASA.

  17. Advances in low-level jet research and future prospects

    NASA Astrophysics Data System (ADS)

    Liu, Hongbo; He, Mingyang; Wang, Bin; Zhang, Qinghong

    2014-02-01

    The low-level jet (LLJ) is closely related to severe rainfall events, air pollution, wind energy utilization, aviation safety, sandstorms, forest fire, and other weather and climate phenomena. Therefore, it has attracted considerable attention since its discovery. Scientists have carried out many studies on LLJs and made significant achievements during the past five or six decades. This article summarizes and assesses the current knowledge on this subject, and focuses in particular on three aspects: 1) LLJ classification, definition, distribution, and structure; 2) LLJ formation and evolutionary mechanisms; and 3) relationships between LLJ and rainfall, as well as other interdisciplinary fields. After comparing the status of LLJ research at home (China) and abroad, we then discuss the shortcomings of LLJ research in China. We suggest that this includes: coarse definitions of the LLJ, lack of observations and inadequate quality control, few thorough explorations of LLJ characteristics and formation mechanisms, and limited studies in interdisciplinary fields. The future prospects for several LLJ research avenues are also speculated.

  18. Method and apparatus for effecting light-off of a catalytic converter in a hybrid powertrain system

    SciTech Connect

    Roos, Bryan Nathaniel; Spohn, Brian L

    2013-07-02

    A powertrain system includes a hybrid transmission and an internal combustion engine coupled to an exhaust aftertreatment device. A method for operating the powertrain system includes operating the hybrid transmission to generate tractive torque responsive to an operator torque request with the internal combustion engine in an engine-off state so long as the tractive torque is less than a threshold. The internal combustion engine is operated in an engine-on state at preferred operating conditions to effect light-off of the exhaust aftertreatment device and the hybrid transmission is coincidentally operated to generate tractive torque responsive to the operator torque request when the operator torque request exceeds the threshold. The internal combustion engine is then operated in the engine-on state to generate tractive torque responsive to the operator torque request.

  19. SALSA (Southwest Advanced Learning System for Adults). Pilot Project Research Report.

    ERIC Educational Resources Information Center

    Rio Salado Community Coll., AZ.

    Researchers at Rio Salado Community College (Arizona) directing an educational research project, called the Southwest Advanced Learning System for Adults (SALSA), placed personal computers in the homes of production line workers as a supplement to traditional classroom basic skills training. Objectives were to determine whether this supplemental…

  20. Advanced gas turbine systems research. Quarterly report, October--December 1995

    SciTech Connect

    1996-01-01

    This report summarizes the major accomplishments and reports issued by Advanced Gas Turbine Systems Research (AGTSR) during October 1, 1995 to December 31, 1995, reports on changes in the AGTSR membership, describes 1993, 1994 and 1995 subcontract progress, third combustion workshop, first combustion specialty meeting, materials workshop, industrial internship, research topics highlighted, and seminar sponsorship.

  1. Prejudice and Racism, Year 2008--Still Going Strong: Research on Reducing Prejudice with Recommended Methodological Advances

    ERIC Educational Resources Information Center

    Utsey, Shawn O.; Ponterotto, Joseph G.; Porter, Jerlym S.

    2008-01-01

    This article addresses the origins, mechanisms, and expressions of prejudice. A selective review of research finds strong support for the validity of G. W. Allport's (1954) contact hypothesis conditions in reducing prejudice. Methodological advances in the study of prejudice are reviewed, and implications of research findings for counselors are…

  2. NASA University Research Centers Technical Advances in Education, Aeronautics, Space, Autonomy, Earth and Environment

    NASA Technical Reports Server (NTRS)

    Jamshidi, M. (Editor); Lumia, R. (Editor); Tunstel, E., Jr. (Editor); White, B. (Editor); Malone, J. (Editor); Sakimoto, P. (Editor)

    1997-01-01

    This first volume of the Autonomous Control Engineering (ACE) Center Press Series on NASA University Research Center's (URC's) Advanced Technologies on Space Exploration and National Service constitute a report on the research papers and presentations delivered by NASA Installations and industry and Report of the NASA's fourteen URC's held at the First National Conference in Albuquerque, New Mexico from February 16-19, 1997.

  3. Status and future directions for advanced accelerator research-conventional and non-conventional collider concepts

    SciTech Connect

    Siemann, R.H.

    1997-03-01

    The relationship between advanced accelerator research and future directions for particle physics is discussed. Comments are made about accelerator research trends in hadron colliders, muon colliders, and e{sup +}e{sup {minus}} linear colliders. {copyright} {ital 1997 American Institute of Physics.}

  4. Advanced Reactor Safety Research Division. Quarterly progress report, April 1-June 30, 1980

    SciTech Connect

    Romano, A.J.

    1980-01-01

    The Advanced Reactor Safety Research Programs Quarterly Progress Report describes current activities and technical progress in the programs at Brookhaven National Laboratory sponsored by the USNRC Division of Reactor Safety Research. The projects reported each quarter are the following: HTGR safety evaluation, SSC Code Development, LMFBR Safety Experiments, and Fast Reactor Safety Code Validation.

  5. Advanced Reactor Safety Research Division. Quarterly progress report, January 1-March 31, 1980

    SciTech Connect

    Agrawal, A.K.; Cerbone, R.J.; Sastre, C.

    1980-06-01

    The Advanced Reactor Safety Research Programs quarterly progress report describes current activities and technical progress in the programs at Brookhaven National Laboratory sponsored by the USNRC Division of Reactor Safety Research. The projects reported each quarter are the following: HTGR Safety Evaluation, SSC Code Development, LMFBR Safety Experiments, and Fast Reactor Safety Code Validation.

  6. Doctoral Research in Educational Leadership: Expectations for Those Thinking about an Advanced Degree

    ERIC Educational Resources Information Center

    Parks, David J.

    2016-01-01

    The tallest hurdle in completing a doctoral degree is the dissertation, which continues to be the primary capstone experience for the degree. Dissertation research is a mystery to many considering an advanced degree and can be intimidating to those who are unfamiliar with the nature of universities and doctoral research. In this report, the author…

  7. 11th Annual NIH Pain Consortium Symposium on Advances in Pain Research | Division of Cancer Prevention

    Cancer.gov

    The NIH Pain Consortium will convene the 11th Annual NIH Pain Consortium Symposium on Advances in Pain Research, featuring keynote speakers and expert panel sessions on Innovative Models and Methods. The first keynote address will be delivered by David J. Clark, MD, PhD, Stanford University entitled “Challenges of Translational Pain Research: What Makes a Good Model?” |

  8. Louisiana: a model for advancing regional e-Research through cyberinfrastructure

    PubMed Central

    Katz, Daniel S.; Allen, Gabrielle; Cortez, Ricardo; Cruz-Neira, Carolina; Gottumukkala, Raju; Greenwood, Zeno D.; Guice, Les; Jha, Shantenu; Kolluru, Ramesh; Kosar, Tevfik; Leger, Lonnie; Liu, Honggao; McMahon, Charlie; Nabrzyski, Jarek; Rodriguez-Milla, Bety; Seidel, Ed; Speyrer, Greg; Stubblefield, Michael; Voss, Brian; Whittenburg, Scott

    2009-01-01

    Louisiana researchers and universities are leading a concentrated, collaborative effort to advance statewide e-Research through a new cyberinfrastructure: computing systems, data storage systems, advanced instruments and data repositories, visualization environments and people, all linked together by software programs and high-performance networks. This effort has led to a set of interlinked projects that have started making a significant difference in the state, and has created an environment that encourages increased collaboration, leading to new e-Research. This paper describes the overall effort, the new projects and environment and the results to date. PMID:19451102

  9. Advances in glucose metabolism research in colorectal cancer

    PubMed Central

    Fang, Sitian; Fang, Xiao

    2016-01-01

    Cancer cells uptake glucose at a higher rate and produce lactic acid rather than metabolizing pyruvate through the tricarboxylic acid cycle. This adaptive metabolic shift is termed the Warburg effect. Recently progress had been made regarding the mechanistic understanding of glucose metabolism and associated diagnostic and therapeutic methods, which have been investigated in colorectal cancer. The majority of novel mechanisms involve important glucose metabolism associated genes and miRNA regulation. The present review discusses the contribution of these research results to facilitate with the development of novel diagnosis and anticancer treatment options. PMID:27602209

  10. Research and Development of Advanced Life Support Equipment.

    DTIC Science & Technology

    1999-02-01

    Wiegman , Janet F. Yarbrough, Shawn R. Zhou, Yi 1989-1997 1,10, 12,26.9,26.14 1983-1995 11,26.8 1993-1997 9 1993-1997 u 1993-1997 1,26.13,26.19 1997...Sustained +GS" (AUACHE 91-21) Fischer MD, Heaps CL, Wiegman JF, Hill RC. Female +GZ tolerance to the 4.5-7 simulated aerial combat maneuvers acceleration...Accomplishments Research reported (DIN A005, DIN A009, DIN A010, and/or DIN A016) from this effort includes: Wiegman JF, Burton RR, Forster EM. The role

  11. [Research advances in circadian rhythm of epileptic seizures].

    PubMed

    Yang, Wen-Qi; Li, Hong

    2017-01-01

    The time phase of epileptic seizures has attracted more and more attention. Epileptic seizures have their own circadian rhythm. The same type of epilepsy has different seizure frequencies in different time periods and states (such as sleeping/awakening state and natural day/night cycle). The circadian rhythm of epileptic seizures has complex molecular and endocrine mechanisms, and currently there are several hypotheses. Clarification of the circadian rhythm of epileptic seizures and prevention and administration according to such circadian rhythm can effectively control seizures and reduce the adverse effects of drugs. The research on the circadian rhythm of epileptic seizures provides a new idea for the treatment of epilepsy.

  12. [Advances in research on allelopathy of ginseng and American ginseng].

    PubMed

    Lei, Fengjie; Zhang, Aihua; Zhang, Qiuju; Zhang, Lianxue

    2010-09-01

    Both ginseng and American ginseng can not be replanted on the same soil consecutively. The article reviews the development and progress of studies on the replant failure of ginseng and American ginseng with a special focus on allelopathy in recent years. The allelopathy effect in ginseng and American ginseng is reviewed from following aspects: collecting and extracting allelochemicals, effects of such allelochemicals on seeds germination, seedlings growth, antioxidant enzyme activities in ginseng roots, growth of ginseng pathogens and ginseng callus, and more. It is presumed that inhibitory allelopathy is one of the many possible factors contributing to the replant failure of ginseng and American ginseng. Based on that, the paper points out problems in current researches on the allelopathic effect of ginseng and American ginseng: the allelochemicals are consist of a mixture, which one plays the specific role is not clear; concentrating on a single allelochemical while ignoring the interaction among allelochemicals. It is suggested that further study for this area should be focused on the interactions among allelochemicals and interactions between allelochemicals and environmental impact factors. Another area of needed research is that of the migration and transformation of allelochemicals in soil and microbial involvement in allelopathy on the growth of ginseng and American ginseng.

  13. Advances in drug metabolism and pharmacogenetics research in Australia.

    PubMed

    Mackenzie, Peter I; Somogyi, Andrew A; Miners, John O

    2017-02-01

    Metabolism facilitates the elimination, detoxification and excretion in urine or bile (as biotransformation products) of a myriad of structurally diverse drugs and other chemicals. The metabolism of drugs, non-drug xenobiotics and many endogenous compounds is catalyzed by families of drug metabolizing enzymes (DMEs). These include the hemoprotein-containing cytochromes P450, which function predominantly as monooxygenases, and conjugation enzymes that transfer a sugar, sulfate, acetate or glutathione moiety to substrates containing a suitable acceptor functional group. Drug and chemical metabolism, especially the enzymes that catalyse these reactions, has been the research focus of several groups in Australia for over four decades. In this review, we highlight the role of recent and current drug metabolism research in Australia, including elucidation of the structure and function of enzymes from the various DME families, factors that modulate enzyme activity in humans (e.g. drug-drug interactions, gene expression and genetic polymorphism) and the application of in vitro approaches for the prediction of drug metabolism parameters in humans, along with the broader pharmacological/clinical pharmacological and toxicological significance of drug metabolism and DMEs and their relevance to drug discovery and development, and to clinical practice.

  14. [Research advance in seed germination of desert woody plants].

    PubMed

    Chang, Wei; Wu, Jian-guo; Liu, Yan-hong

    2007-02-01

    This paper reviewed the research methods of desert woody plants seed germination, and the effects of internal and external ecological factors on it. Most researchers use incubator and artificial climate chamber to dispose the seeds, while field investigation was few involved. Seed dormancy is the important physiological factor affecting germination, while seed size, mass and color are closely correlated with its maturity and vigor. The poor permeability of seed capsule is a barrier that restrains the germination, which can be weakened or eliminated by shaving, cutting, treating with low temperature, and dipping in chemical reagent, etc. Seed water content has a close correlation with its storage life and water-absorbing capability. Suitable temperature is the prerequisite of seed germination, while changing temperature can accelerate the germination. Soil moisture content is a limiting factor, while illumination is not so essential to the seed germination of most desert woody plants. Sand-burying plays an important role in the seed germination through regulating illumination, temperature, and soil moisture content. Salinity stress restrains the seed germination of desert woody plants observably. In further studies, the effects of multi-factors and the eco-physiological and molecular biological mechanisms of germination should be more concerned.

  15. [Research advances in ecological stoichiometry of marine plankton].

    PubMed

    Chen, Lei; Li, Chao-Lun

    2014-10-01

    Ecological stoichiometry can be simply defined as: The biology of elements from molecules to the biosphere, which spans all levels of the environment and of the life. It's a new idea to build a unified theory and becomes an inevitable trend to develop the ecological science. Marine ecosystems, which contribute to 50% of the biosphere biomass, are the important component of the global biogeochemical cycles. Marine zooplankton plays an important role in the material circulation and energy flow of marine ecosystems and serves as a connecting link between the preceding and the following in a more precise understanding of the key elemental cycles. However, research on ecological stoichiometry of marine plankton is fragmentary and rare. This article summarized the ecological phenomena and mechanisms of limiting elements affecting marine plankton, the response of biochemical substances to nutrition limitation, and the food chain transmission and feedback of nutrition limitation. Meanwhile, we also put forward some perspectives for future research of ecological stoichiometry of plankton in China' s seas.

  16. Advancement in the development of models for hepatitis C research.

    PubMed

    Carcamo, Wendy C; Nguyen, Cuong Q

    2012-01-01

    Hepatitis C virus (HCV) is a pandemic disease affecting an estimated 180 million individuals worldwide and infecting each year another ~3-4 million people making HCV a global public health issue. HCV is the main cause for chronic hepatitis, cirrhosis, and hepatocellular carcinoma. In the United States, HCV-related chronic liver disease is a leading cause of liver transplantation. Despite significant improvements in antiviral drugs, only ~50% of treated patients with HCV have viral clearance after treatment. Showing unique species specificity, HCV has a narrow range of potential hosts infecting only chimpanzees and humans. For decades, the chimpanzee model has been the only and instrumental primate for studying HCV infection; however, availability, economic, and ethical issues make the chimpanzee an unsuitable animal model today. Thus, significant research has been devoted to explore different models that are suitable in studying the biology of the virus and application in the clinical research for developing efficient and tolerable treatments for patients. This review focuses on experimental models that have been developed to date and their findings related to HCV.

  17. Current preclinical models for the advancement of translational bladder cancer research.

    PubMed

    DeGraff, David J; Robinson, Victoria L; Shah, Jay B; Brandt, William D; Sonpavde, Guru; Kang, Yibin; Liebert, Monica; Wu, Xue-Ru; Taylor, John A

    2013-02-01

    Bladder cancer is a common disease representing the fifth most diagnosed solid tumor in the United States. Despite this, advances in our understanding of the molecular etiology and treatment of bladder cancer have been relatively lacking. This is especially apparent when recent advances in other cancers, such as breast and prostate, are taken into consideration. The field of bladder cancer research is ready and poised for a series of paradigm-shifting discoveries that will greatly impact the way this disease is clinically managed. Future preclinical discoveries with translational potential will require investigators to take full advantage of recent advances in molecular and animal modeling methodologies. We present an overview of current preclinical models and their potential roles in advancing our understanding of this deadly disease and for advancing care.

  18. Research advances in amyotrophic lateral sclerosis, 2009 to 2010.

    PubMed

    Traub, Rebecca; Mitsumoto, Hiroshi; Rowland, Lewis P

    2011-02-01

    Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of upper and lower motor neurons that causes progressive weakness and death. The breadth of research in ALS continues to grow with exciting new discoveries in disease pathogenesis and potential future therapeutics. There is a growing list of identified mutations in familial ALS, including those in genes encoding TDP-43 and FUS/TLS, which are expanding our understanding of the role of RNA modulation in ALS pathogenesis. There is a greater appreciation for the role of glial cells in motor neuron disease. Mitochondrial dysfunction is also being shown to be critical for motor neuron degeneration. In addition to pharmacotherapy, there are promising early developments with therapeutic implications in the areas of RNA interference, stem cell therapies, viral vector-mediated gene therapy, and immunotherapy. With greater understanding of ALS pathogenesis and exciting new therapeutic technologies, there is hope for future progress in treating this disease.

  19. Advances and remaining challenges in adult literacy research.

    PubMed

    Miller, Brett; McCardle, Peggy; Hernandez, Ricardo

    2010-01-01

    Low literacy levels in adult learners pose an educational and public health challenge to practitioners and the scientific community. Increasing demands placed on literacy can limit opportunities in the workplace and access to health-related resources, negatively affecting public health. Current estimates from the National Center for Education Statistics suggest that more than 40 million adults in the United States possess only the most basic and concrete literacy skills. Despite the estimated number of learners possessing minimal literacy skills in English in the United States, there remains a paucity of research focused on adult learners to inform remediation efforts. This special issue of the Journal of Learning Disabilities represents an important step in highlighting the current scientific knowledge base and the implications for future directions and lines of inquiry with adult learners.

  20. Vanadium, recent advancements and research prospects: A review.

    PubMed

    Imtiaz, Muhammad; Rizwan, Muhammad Shahid; Xiong, Shuanglian; Li, Hailan; Ashraf, Muhammad; Shahzad, Sher Muhammad; Shahzad, Muhammad; Rizwan, Muhammad; Tu, Shuxin

    2015-07-01

    Metal pollution is an important issue worldwide, with various documented cases of metal toxicity in mining areas, industries, coal power plants and agriculture sector. Heavy metal polluted soils pose severe problems to plants, water resources, environment and nutrition. Among all non-essential metals, vanadium (V) is becoming a serious matter of discussion for the scientists who deals with heavy metals. Due to its mobility from soil to plants, it causes adverse effects to human beings. This review article illustrates briefly about V, its role and shows the progress about V research so far done globally in the light of the previous work which may assist in inter-disciplinary studies to evaluate the ecological importance of V toxicity.