Science.gov

Sample records for advanced reach tool

  1. Advanced REACH Tool: A Bayesian Model for Occupational Exposure Assessment

    PubMed Central

    McNally, Kevin; Warren, Nicholas; Fransman, Wouter; Entink, Rinke Klein; Schinkel, Jody; van Tongeren, Martie; Cherrie, John W.; Kromhout, Hans; Schneider, Thomas; Tielemans, Erik

    2014-01-01

    This paper describes a Bayesian model for the assessment of inhalation exposures in an occupational setting; the methodology underpins a freely available web-based application for exposure assessment, the Advanced REACH Tool (ART). The ART is a higher tier exposure tool that combines disparate sources of information within a Bayesian statistical framework. The information is obtained from expert knowledge expressed in a calibrated mechanistic model of exposure assessment, data on inter- and intra-individual variability in exposures from the literature, and context-specific exposure measurements. The ART provides central estimates and credible intervals for different percentiles of the exposure distribution, for full-shift and long-term average exposures. The ART can produce exposure estimates in the absence of measurements, but the precision of the estimates improves as more data become available. The methodology presented in this paper is able to utilize partially analogous data, a novel approach designed to make efficient use of a sparsely populated measurement database although some additional research is still required before practical implementation. The methodology is demonstrated using two worked examples: an exposure to copper pyrithione in the spraying of antifouling paints and an exposure to ethyl acetate in shoe repair. PMID:24665110

  2. Tool Enlarges Hard-to-Reach Holes

    NASA Technical Reports Server (NTRS)

    Geddes, J. P.

    1984-01-01

    Tool centers itself and cuts precise depth. Tool consists of crosscut carbide bur; sleeve that serves as depth stop and pilot; length of flexible, strong piano wire; and standard drive socket. Parts brazed together. Piano wire transmits torque and axial force to cutting tool.

  3. Action, perception and postural planning when reaching for tools.

    PubMed

    Sunderland, Alan

    2013-06-01

    The dorsal and ventral streams model of action and perception suggests that reaching to grasp a tool for use involves integrated operation of the two streams. Few attempts have been made to test the limits of this integration in normal subjects. Twenty normal subjects reached for tools or geometric objects which were rotated rapidly during reaching or immediately beforehand. In a first experiment it was shown that reaching for an inverted tool was slower than reaching for objects which required hand inversion due to proximity to a physical barrier. Also, for the right hand, tool rotation during reaching provoked a higher incidence of hand rotation in the wrong direction than did rotation of objects. In a second similar experiment, hand inversion when grasping objects was induced by the need to plan a future action rather than by proximity of a physical barrier. Despite this balancing of complexity of postural planning for tools and objects, hand rotation errors for both hands were more common for tools than objects. This was consistent with the two-stream model in suggesting that there was a process which produced rapid online tracking of stimulus rotation and this had to be overcome by a slower process which dictated grasping in accordance with knowledge of tool use.

  4. Advanced Prosthetic Gait Training Tool

    DTIC Science & Technology

    2011-09-01

    AD_________________ Award Number: W81XWH-10-1-0870 TITLE: Advanced Prosthetic Gait Training Tool...Advanced Prosthetic Gait Training Tool 5b. GRANT NUMBER W81XWH-10-1-0870 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER Rajankumar...produce a computer-based Advanced Prosthetic Gait Training Tool to aid in the training of clinicians at military treatment facilities providing care for

  5. Advanced Prosthetic Gait Training Tool

    DTIC Science & Technology

    2015-12-01

    study is to produce a computer-based Advanced Prosthetic Gait Training Tool to aid in the training of clinicians at military treatment facilities...providing care for wounded service members. In Phase I of the effort, significant work was completed at the University of Iowa Center for Computer- Aided ...Gait Training Tool Introduction The objective of our study is to produce a computer-based Advanced Prosthetic Gait Training Tool (APGTT) to aid in

  6. Advanced Welding Tool

    NASA Technical Reports Server (NTRS)

    1982-01-01

    Accutron Tool & Instrument Co.'s welder was originally developed as a tool specifically for joining parts made of plastic or composite materials in any atmosphere to include the airless environment of space. Developers decided on induction or magnetic heating to avoid causing deformation and it also can be used with almost any type of thermoplastic material. Induction coil transfers magnetic flux through the plastic to a metal screen that is sandwiched between the sheets of plastic to be joined. When welder is energized, alternating current produces inductive heating on the screen causing the adjacent plastic surfaces to melt and flow into the mesh, creating a bond on the total surface area. Dave Brown, owner of Great Falls Canoe and Kayak Repair, Vienna, VA, uses a special repair technique based on operation of the Induction Toroid Welder to fix canoes. Whitewater canoeing poses the problem of frequent gashes that are difficult to repair. The main reason is that many canoes are made of plastics. The commercial Induction model is a self-contained, portable welding gun with a switch on the handle to regulate the temperature of the plastic melting screen. Welder has a broad range of applications in the automobile, appliance, aerospace and construction industries.

  7. Modeling Tool Advances Rotorcraft Design

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Continuum Dynamics Inc. (CDI), founded in 1979, specializes in advanced engineering services, including fluid dynamic modeling and analysis for aeronautics research. The company has completed a number of SBIR research projects with NASA, including early rotorcraft work done through Langley Research Center, but more recently, out of Ames Research Center. NASA Small Business Innovation Research (SBIR) grants on helicopter wake modeling resulted in the Comprehensive Hierarchical Aeromechanics Rotorcraft Model (CHARM), a tool for studying helicopter and tiltrotor unsteady free wake modeling, including distributed and integrated loads, and performance prediction. Application of the software code in a blade redesign program for Carson Helicopters, of Perkasie, Pennsylvania, increased the payload and cruise speeds of its S-61 helicopter. Follow-on development resulted in a $24 million revenue increase for Sikorsky Aircraft Corporation, of Stratford, Connecticut, as part of the company's rotor design efforts. Now under continuous development for more than 25 years, CHARM models the complete aerodynamics and dynamics of rotorcraft in general flight conditions. CHARM has been used to model a broad spectrum of rotorcraft attributes, including performance, blade loading, blade-vortex interaction noise, air flow fields, and hub loads. The highly accurate software is currently in use by all major rotorcraft manufacturers, NASA, the U.S. Army, and the U.S. Navy.

  8. Advanced Human Factors Engineering Tool Technologies.

    DTIC Science & Technology

    1987-03-20

    identified the types of tools they would like to see V developed to fill the existing technology gaps. The advanced tools were catego- rized using an...the prototype phase of development were considered candidates for inclusion. The advanced tools were next categorized using an eight point...role, application, status and cost. Decision criteria were then developed as the basis for the tradeoff process to aid in tool selection. To

  9. ADVANCED POWER SYSTEMS ANALYSIS TOOLS

    SciTech Connect

    Robert R. Jensen; Steven A. Benson; Jason D. Laumb

    2001-08-31

    The use of Energy and Environmental Research Center (EERC) modeling tools and improved analytical methods has provided key information in optimizing advanced power system design and operating conditions for efficiency, producing minimal air pollutant emissions and utilizing a wide range of fossil fuel properties. This project was divided into four tasks: the demonstration of the ash transformation model, upgrading spreadsheet tools, enhancements to analytical capabilities using the scanning electron microscopy (SEM), and improvements to the slag viscosity model. The ash transformation model, Atran, was used to predict the size and composition of ash particles, which has a major impact on the fate of the combustion system. To optimize Atran key factors such as mineral fragmentation and coalescence, the heterogeneous and homogeneous interaction of the organically associated elements must be considered as they are applied to the operating conditions. The resulting model's ash composition compares favorably to measured results. Enhancements to existing EERC spreadsheet application included upgrading interactive spreadsheets to calculate the thermodynamic properties for fuels, reactants, products, and steam with Newton Raphson algorithms to perform calculations on mass, energy, and elemental balances, isentropic expansion of steam, and gasifier equilibrium conditions. Derivative calculations can be performed to estimate fuel heating values, adiabatic flame temperatures, emission factors, comparative fuel costs, and per-unit carbon taxes from fuel analyses. Using state-of-the-art computer-controlled scanning electron microscopes and associated microanalysis systems, a method to determine viscosity using the incorporation of grey-scale binning acquired by the SEM image was developed. The image analysis capabilities of a backscattered electron image can be subdivided into various grey-scale ranges that can be analyzed separately. Since the grey scale's intensity is

  10. Recent Advances in Algal Genetic Tool Development

    SciTech Connect

    R. Dahlin, Lukas; T. Guarnieri, Michael

    2016-06-24

    The goal of achieving cost-effective biofuels and bioproducts derived from algal biomass will require improvements along the entire value chain, including identification of robust, high-productivity strains and development of advanced genetic tools. Though there have been modest advances in development of genetic systems for the model alga Chlamydomonas reinhardtii, progress in development of algal genetic tools, especially as applied to non-model algae, has generally lagged behind that of more commonly utilized laboratory and industrial microbes. This is in part due to the complex organellar structure of algae, including robust cell walls and intricate compartmentalization of target loci, as well as prevalent gene silencing mechanisms, which hinder facile utilization of conventional genetic engineering tools and methodologies. However, recent progress in global tool development has opened the door for implementation of strain-engineering strategies in industrially-relevant algal strains. Here, we review recent advances in algal genetic tool development and applications in eukaryotic microalgae.

  11. Rapid medical advances challenge the tooling industry.

    PubMed

    Conley, B

    2008-01-01

    The requirement for greater performance in smaller spaces has increased demands for product and process innovation in tubing and other medical products. In turn, these developments have placed greater demands on the producers of the advanced tooling for these products. Tooling manufacturers must now continuously design equipment with much tighter tolerances for more sophisticated coextrusions and for newer generations of multilumen and multilayer tubing.

  12. Postural and Object-Oriented Experiences Advance Early Reaching, Object Exploration, and Means-End Behavior

    ERIC Educational Resources Information Center

    Lobo, Michele A.; Galloway, James C.

    2008-01-01

    The effects of 3 weeks of social (control), postural, or object-oriented experiences on 9- to 21-week-old infants' (N = 42) reaching, exploration, and means-end behaviors were assessed. Coders recorded object contacts, mouthing, fingering, attention, and affect from video. Postural and object-oriented experiences advanced reaching, haptic…

  13. Astronaut John Young reaches for tools in Lunar Roving Vehicle during EVA

    NASA Technical Reports Server (NTRS)

    1972-01-01

    Astronaut John W. Young, commander of the Apollo 16 lunar landing mission, reaches for tools in the Apollo lunar hand tool carrier at the aft end of the Lunar Roving Vehicle during the second Apollo 16 extravehicular activity (EVA-2) at the Descartes landing site. This photograph was taken by Astronaut Charles M. Duke Jr., lunar module pilot. This view is looking south from the base of Stone Mountain.

  14. Recent Advances in Algal Genetic Tool Development

    DOE PAGES

    R. Dahlin, Lukas; T. Guarnieri, Michael

    2016-06-24

    The goal of achieving cost-effective biofuels and bioproducts derived from algal biomass will require improvements along the entire value chain, including identification of robust, high-productivity strains and development of advanced genetic tools. Though there have been modest advances in development of genetic systems for the model alga Chlamydomonas reinhardtii, progress in development of algal genetic tools, especially as applied to non-model algae, has generally lagged behind that of more commonly utilized laboratory and industrial microbes. This is in part due to the complex organellar structure of algae, including robust cell walls and intricate compartmentalization of target loci, as well asmore » prevalent gene silencing mechanisms, which hinder facile utilization of conventional genetic engineering tools and methodologies. However, recent progress in global tool development has opened the door for implementation of strain-engineering strategies in industrially-relevant algal strains. Here, we review recent advances in algal genetic tool development and applications in eukaryotic microalgae.« less

  15. Advanced genetic tools for plant biotechnology.

    PubMed

    Liu, Wusheng; Yuan, Joshua S; Stewart, C Neal

    2013-11-01

    Basic research has provided a much better understanding of the genetic networks and regulatory hierarchies in plants. To meet the challenges of agriculture, we must be able to rapidly translate this knowledge into generating improved plants. Therefore, in this Review, we discuss advanced tools that are currently available for use in plant biotechnology to produce new products in plants and to generate plants with new functions. These tools include synthetic promoters, 'tunable' transcription factors, genome-editing tools and site-specific recombinases. We also review some tools with the potential to enable crop improvement, such as methods for the assembly and synthesis of large DNA molecules, plant transformation with linked multigenes and plant artificial chromosomes. These genetic technologies should be integrated to realize their potential for applications to pressing agricultural and environmental problems.

  16. Advanced genetic tools for plant biotechnology

    SciTech Connect

    Liu, WS; Yuan, JS; Stewart, CN

    2013-10-09

    Basic research has provided a much better understanding of the genetic networks and regulatory hierarchies in plants. To meet the challenges of agriculture, we must be able to rapidly translate this knowledge into generating improved plants. Therefore, in this Review, we discuss advanced tools that are currently available for use in plant biotechnology to produce new products in plants and to generate plants with new functions. These tools include synthetic promoters, 'tunable' transcription factors, genome-editing tools and site-specific recombinases. We also review some tools with the potential to enable crop improvement, such as methods for the assembly and synthesis of large DNA molecules, plant transformation with linked multigenes and plant artificial chromosomes. These genetic technologies should be integrated to realize their potential for applications to pressing agricultural and environmental problems.

  17. Contribution of the posterior parietal cortex in reaching, grasping, and using objects and tools

    PubMed Central

    Vingerhoets, Guy

    2014-01-01

    Neuropsychological and neuroimaging data suggest a differential contribution of posterior parietal regions during the different components of a transitive gesture. Reaching requires the integration of object location and body position coordinates and reaching tasks elicit bilateral activation in different foci along the intraparietal sulcus. Grasping requires a visuomotor match between the object's shape and the hand's posture. Lesion studies and neuroimaging confirm the importance of the anterior part of the intraparietal sulcus for human grasping. Reaching and grasping reveal bilateral activation that is generally more prominent on the side contralateral to the hand used or the hemifield stimulated. Purposeful behavior with objects and tools can be assessed in a variety of ways, including actual use, pantomimed use, and pure imagery of manipulation. All tasks have been shown to elicit robust activation over the left parietal cortex in neuroimaging, but lesion studies have not always confirmed these findings. Compared to pantomimed or imagined gestures, actual object and tool use typically produces activation over the left primary somatosensory region. Neuroimaging studies on pantomiming or imagery of tool use in healthy volunteers revealed neural responses in possibly separate foci in the left supramarginal gyrus. In sum, the parietal contribution of reaching and grasping of objects seems to depend on a bilateral network of intraparietal foci that appear organized along gradients of sensory and effector preferences. Dorsal and medial parietal cortex appears to contribute to the online monitoring/adjusting of the ongoing prehensile action, whereas the functional use of objects and tools seems to involve the inferior lateral parietal cortex. This functional input reveals a clear left lateralized activation pattern that may be tuned to the integration of acquired knowledge in the planning and guidance of the transitive movement. PMID:24634664

  18. Self-advancing step-tap tool

    NASA Technical Reports Server (NTRS)

    Pettit, Donald R. (Inventor); Penner, Ronald K. (Inventor); Franklin, Larry D. (Inventor); Camarda, Charles J. (Inventor)

    2008-01-01

    Methods and tool for simultaneously forming a bore in a work piece and forming a series of threads in said bore. In an embodiment, the tool has a predetermined axial length, a proximal end, and a distal end, said tool comprising: a shank located at said proximal end; a pilot drill portion located at said distal end; and a mill portion intermediately disposed between said shank and said pilot drill portion. The mill portion is comprised of at least two drill-tap sections of predetermined axial lengths and at least one transition section of predetermined axial length, wherein each of said at least one transition section is sandwiched between a distinct set of two of said at least two drill-tap sections. The at least two drill-tap sections are formed of one or more drill-tap cutting teeth spirally increasing along said at least two drill-tap sections, wherein said tool is self-advanced in said work piece along said formed threads, and wherein said tool simultaneously forms said bore and said series of threads along a substantially similar longitudinal axis.

  19. Identifying fecal sources in a selected catchment reach using multiple source-tracking tools

    USGS Publications Warehouse

    Vogel, J.R.; Stoeckel, D.M.; Lamendella, R.; Zelt, R.B.; Santo, Domingo J.W.; Walker, S.R.; Oerther, D.B.

    2007-01-01

    Given known limitations of current microbial source-tracking (MST) tools, emphasis on small, simple study areas may enhance interpretations of fecal contamination sources in streams. In this study, three MST tools - Escherichia coli repetitive element polymerase chain reaction (rep-PCR), coliphage typing, and Bacteroidales 16S rDNA host-associated markers - were evaluated in a selected reach of Plum Creek in sooth-central Nebraska. Water-quality samples were collected from six sites. One reach was selected for MST evaluation based on observed patterns of E. coli contamination. Despite high E. coli concentrations, coliphages were detected only once among water samples, precluding their use as a MST tool in this setting. Rep-PCR classification of E. coli isolates from both water and sediment samples supported the hypothesis that cattle and wildlife were dominant sources of fecal contamination, with minor contributions by horses and humans. Conversely, neither ruminant nor human sources were detected by Bacteroidales markers in most water samples. In bed sediment, ruminant- and human-associated Bacteroidales markers were detected throughout the interval from 0 to 0.3 m, with detections independent of E. coli concentrations in the sediment. Although results by E. coli-based and Bacteroidales-based MST methods led to similar interpretations, detection of Bacteroidales markers in sediment more commonly than in water indicates that different tools to track fecal contamination (in this case, tools based on Bacteroidales DNA and E. coli isolates) may have varying relevance to the more specific goal of tracking the sources of E. coli in watersheds. This is the first report of simultaneous, toolbox approach application of a library-based and marker-based MST analyses to lowing surface water. ?? ASA, CSSA, SSSA.

  20. Developing a Web-based Tool Using Information and Communication Technologies to Expand the Reach and Impact of Photovoice.

    PubMed

    Strack, Robert W; Orsini, Muhsin Michael; Fearnow-Kenney, Melodie; Herget, Jennifer; Milroy, Jeffrey J; Wyrick, David L

    Information and communication technologies are opening up vast new arenas for conducting the work of health promotion. Technology-based health promotions expand reach, standardize information and its delivery, provide opportunities for tailoring, create engaging interactivity within content delivery, provide for privacy and autonomy, improve portability, and lower delivery costs. This commentary describes the ongoing exploration and development of a web-based tool for enhancing the reach and impact of photovoice as a community change intervention. Features of the tool use information and communication technologies that integrate the use of an online learning management system, tailored messaging, gaming technology, interactive features, and the application of social media's power to increase the capacity of communities to employ comprehensive strategies to improve the health of their communities. It will enable individuals and groups to use photos and captions to assess the physical environment, social norms and behaviors of communities; raise community awareness of the factors contributing to ill-health in their communities, mobilize stakeholders, and inform environmental strategies and policy changes. We believe it will enhance the delivery of educational content about conducting photovoice projects, provide features unavailable without the application of information and communication technologies, and will be substantive advancement over existing photovoice resources.

  1. Extended reach drilling advancements dramatically improve performance on Bass Strait wells

    SciTech Connect

    Santostefano, V.; Krepp, A.N.

    1994-12-31

    Esso Australia Ltd. (EAL) has been drilling deviated wells in Bass Strait since 1968. Recent technological developments have been employed on the Mackerel Infill Drilling Project, that have significantly improved EAL`s ability to drill Long Reach (LR)/Extended Reach (ER) wells more economically and consistently. The more notable achievements have been: advancements in hole condition reporting, utilizing torque and drag monitoring; the successful use of non-rotating drillpipe rubbers to reduce surface torque to acceptable levels; deeper casing setting depths, to minimize torque and drag, and to reduce time-dependent hole problems; the use of inhibitive/encapsulating mud systems for control of reactive clays/shales; and use of wellbore stability modeling. These advancements have helped EAL to drill 50% greater meterage than was expected in 1993, at 16% lower cost per meter. This paper chronicles the engineering decisions behind these advancements, their applications in the field, the success/failure story on Mackerel to date, and how these developments have been incorporated in EAL`s future well planning.

  2. Advanced cryogenics for cutting tools. Final report

    SciTech Connect

    Lazarus, L.J.

    1996-10-01

    The purpose of the investigation was to determine if cryogenic treatment improved the life and cost effectiveness of perishable cutting tools over other treatments or coatings. Test results showed that in five of seven of the perishable cutting tools tested there was no improvement in tool life. The other two tools showed a small gain in tool life, but not as much as when switching manufacturers of the cutting tool. The following conclusions were drawn from this study: (1) titanium nitride coatings are more effective than cryogenic treatment in increasing the life of perishable cutting tools made from all cutting tool materials, (2) cryogenic treatment may increase tool life if the cutting tool is improperly heat treated during its origination, and (3) cryogenic treatment was only effective on those tools made from less sophisticated high speed tool steels. As a part of a recent detailed investigation, four cutting tool manufacturers and two cutting tool laboratories were queried and none could supply any data to substantiate cryogenic treatment of perishable cutting tools.

  3. Advanced Human Factors Engineering Tool Technologies.

    DTIC Science & Technology

    1988-03-01

    representing the government, the military, academe, and private industry were surveyed to identify those tools that are most frequently used or viewed...tools by HFE researchers and practitioners within the academic, industrial , and military settings. % .. J. &@ossion For XTIS GR&&I DTIC TAS 0...267 E. Human Factors Engineering Tools Questionnaire .. ......... . 279 F. Listing of Industry , Government, and Academe

  4. A Method for Consensus Reaching in Product Kansei Evaluation Using Advanced Particle Swarm Optimization

    PubMed Central

    2017-01-01

    Consumers' opinions toward product design alternatives are often subjective and perceptual, which reflect their perception about a product and can be described using Kansei adjectives. Therefore, Kansei evaluation is often employed to determine consumers' preference. However, how to identify and improve the reliability of consumers' Kansei evaluation opinions toward design alternatives has an important role in adding additional insurance and reducing uncertainty to successful product design. To solve this problem, this study employs a consensus model to measure consistence among consumers' opinions, and an advanced particle swarm optimization (PSO) algorithm combined with Linearly Decreasing Inertia Weight (LDW) method is proposed for consensus reaching by minimizing adjustment of consumers' opinions. Furthermore, the process of the proposed method is presented and the details are illustrated using an example of electronic scooter design evaluation. The case study reveals that the proposed method is promising for reaching a consensus through searching optimal solutions by PSO and improving the reliability of consumers' evaluation opinions toward design alternatives according to Kansei indexes. PMID:28316619

  5. A Method for Consensus Reaching in Product Kansei Evaluation Using Advanced Particle Swarm Optimization.

    PubMed

    Yang, Yan-Pu

    2017-01-01

    Consumers' opinions toward product design alternatives are often subjective and perceptual, which reflect their perception about a product and can be described using Kansei adjectives. Therefore, Kansei evaluation is often employed to determine consumers' preference. However, how to identify and improve the reliability of consumers' Kansei evaluation opinions toward design alternatives has an important role in adding additional insurance and reducing uncertainty to successful product design. To solve this problem, this study employs a consensus model to measure consistence among consumers' opinions, and an advanced particle swarm optimization (PSO) algorithm combined with Linearly Decreasing Inertia Weight (LDW) method is proposed for consensus reaching by minimizing adjustment of consumers' opinions. Furthermore, the process of the proposed method is presented and the details are illustrated using an example of electronic scooter design evaluation. The case study reveals that the proposed method is promising for reaching a consensus through searching optimal solutions by PSO and improving the reliability of consumers' evaluation opinions toward design alternatives according to Kansei indexes.

  6. Modelling the sensitivity of river reaches to water abstraction: RAPHSA- a hydroecology tool for environmental managers

    NASA Astrophysics Data System (ADS)

    Klaar, Megan; Laize, Cedric; Maddock, Ian; Acreman, Mike; Tanner, Kath; Peet, Sarah

    2014-05-01

    A key challenge for environmental managers is the determination of environmental flows which allow a maximum yield of water resources to be taken from surface and sub-surface sources, whilst ensuring sufficient water remains in the environment to support biota and habitats. It has long been known that sensitivity to changes in water levels resulting from river and groundwater abstractions varies between rivers. Whilst assessment at the catchment scale is ideal for determining broad pressures on water resources and ecosystems, assessment of the sensitivity of reaches to changes in flow has previously been done on a site-by-site basis, often with the application of detailed but time consuming techniques (e.g. PHABSIM). While this is appropriate for a limited number of sites, it is costly in terms of money and time resources and therefore not appropriate for application at a national level required by responsible licensing authorities. To address this need, the Environment Agency (England) is developing an operational tool to predict relationships between physical habitat and flow which may be applied by field staff to rapidly determine the sensitivity of physical habitat to flow alteration for use in water resource management planning. An initial model of river sensitivity to abstraction (defined as the change in physical habitat related to changes in river discharge) was developed using site characteristics and data from 66 individual PHABSIM surveys throughout the UK (Booker & Acreman, 2008). By applying a multivariate multiple linear regression analysis to the data to define habitat availability-flow curves using resource intensity as predictor variables, the model (known as RAPHSA- Rapid Assessment of Physical Habitat Sensitivity to Abstraction) is able to take a risk-based approach to modeled certainty. Site specific information gathered using desk-based, or a variable amount of field work can be used to predict the shape of the habitat- flow curves, with the

  7. Alternative Fuel and Advanced Vehicle Tools (AFAVT), AFDC (Fact Sheet)

    SciTech Connect

    Not Available

    2010-01-01

    The Alternative Fuels and Advanced Vehicles Web site offers a collection of calculators, interactive maps, and informational tools to assist fleets, fuel providers, and others looking to reduce petroleum consumption in the transportation sector.

  8. Innovative Tools Advance Revolutionary Weld Technique

    NASA Technical Reports Server (NTRS)

    2009-01-01

    The iconic, orange external tank of the space shuttle launch system not only contains the fuel used by the shuttle s main engines during liftoff but also comprises the shuttle s backbone, supporting the space shuttle orbiter and solid rocket boosters. Given the tank s structural importance and the extreme forces (7.8 million pounds of thrust load) and temperatures it encounters during launch, the welds used to construct the tank must be highly reliable. Variable polarity plasma arc welding, developed for manufacturing the external tank and later employed for building the International Space Station, was until 1994 the best process for joining the aluminum alloys used during construction. That year, Marshall Space Flight Center engineers began experimenting with a relatively new welding technique called friction stir welding (FSW), developed in 1991 by The Welding Institute, of Cambridge, England. FSW differs from traditional fusion welding in that it is a solid-state welding technique, using frictional heat and motion to join structural components without actually melting any of the material. The weld is created by a shouldered pin tool that is plunged into the seam of the materials to be joined. The tool traverses the line while rotating at high speeds, generating friction that heats and softens but does not melt the metal. (The heat produced approaches about 80 percent of the metal s melting temperature.) The pin tool s rotation crushes and stirs the plasticized metal, extruding it along the seam as the tool moves forward. The material cools and consolidates, resulting in a weld with superior mechanical properties as compared to those weld properties of fusion welds. The innovative FSW technology promises a number of attractive benefits. Because the welded materials are not melted, many of the undesirables associated with fusion welding porosity, cracking, shrinkage, and distortion of the weld are minimized or avoided. The process is more energy efficient, safe

  9. Intelligent Software Tools for Advanced Computing

    SciTech Connect

    Baumgart, C.W.

    2001-04-03

    Feature extraction and evaluation are two procedures common to the development of any pattern recognition application. These features are the primary pieces of information which are used to train the pattern recognition tool, whether that tool is a neural network, a fuzzy logic rulebase, or a genetic algorithm. Careful selection of the features to be used by the pattern recognition tool can significantly streamline the overall development and training of the solution for the pattern recognition application. This report summarizes the development of an integrated, computer-based software package called the Feature Extraction Toolbox (FET), which can be used for the development and deployment of solutions to generic pattern recognition problems. This toolbox integrates a number of software techniques for signal processing, feature extraction and evaluation, and pattern recognition, all under a single, user-friendly development environment. The toolbox has been developed to run on a laptop computer, so that it may be taken to a site and used to develop pattern recognition applications in the field. A prototype version of this toolbox has been completed and is currently being used for applications development on several projects in support of the Department of Energy.

  10. Terahertz Tools Advance Imaging for Security, Industry

    NASA Technical Reports Server (NTRS)

    2010-01-01

    Picometrix, a wholly owned subsidiary of Advanced Photonix Inc. (API), of Ann Arbor, Michigan, invented the world s first commercial terahertz system. The company improved the portability and capabilities of their systems through Small Business Innovation Research (SBIR) agreements with Langley Research Center to provide terahertz imaging capabilities for inspecting the space shuttle external tanks and orbiters. Now API s systems make use of the unique imaging capacity of terahertz radiation on manufacturing floors, for thickness measurements of coatings, pharmaceutical tablet production, and even art conservation.

  11. Reach for Reference. BrainPOP--A Teaching Tool Library Media Specialists Should Know

    ERIC Educational Resources Information Center

    Safford, Barbara Ripp

    2005-01-01

    This column describes a new teaching tool, BrainPOP, which is a database that blurs the distinction between classroom and library media center. This collection of more than 300 short, concept-based, animated movies is intended primarily for use by teachers in classroom instruction. It is reminiscent of the single-concept film cartridges that used…

  12. Hangout with CERN: Reaching the Public with the Collaborative Tools of Social Media

    NASA Astrophysics Data System (ADS)

    Goldfarb, S.; Kahle, K. L. M.; Rao, A.

    2014-06-01

    On 4 July 2012, particle physics became a celebrity. Around 1,000,000,000 people (yes, 1 billion) [1] saw rebroadcasts of two technical presentations announcing the discovery of a new boson. The occasion was a joint seminar of the CMS [2] and ATLAS [3] collaborations, and the target audience were particle physicists. Yet the world ate it up like a sporting event. Roughly two days later, in a parallel session of ICHEP in Melbourne, Australia [4], a group of physicists decided to explain the significance of this discovery to the public. They used a tool called "Hangout", part of the relatively new Google+ social media platform [5], to converse directly with the public via a webcast videoconference. The demand to join this Hangout [6] overloaded the server several times. In the end, a compromise involving Q&A via comments was set up, and the conversation was underway. We present a new project born shortly after this experience called Hangout with CERN [7], and discuss its success in creating an effective conversational channel between the public and particle physicists. We review earlier efforts by both CMS and ATLAS contributing to this development, and then describe the current programme, involving nearly all aspects of CERN, and some topics that go well beyond that. We conclude by discussing the potential of the programme both to improve our accountability to the public and to train our community for public communication.

  13. On the use of in silico tools for prioritising toxicity testing of the low-volume industrial chemicals in REACH.

    PubMed

    Rybacka, Aleksandra; Rudén, Christina; Andersson, Patrik L

    2014-07-01

    This study was conducted to evaluate the utility of a selection of commercially and freely available non-testing tools and to analyse how REACH registrants can apply these as prioritisation tool for low-volume chemicals. The analysis was performed on a set of organic industrial chemicals and pesticides with extensive peer-reviewed risk assessment data. Analysed in silico model systems included Derek Nexus, Toxtree, QSAR Toolbox, LAZAR, TEST and VEGA, and results from these were compared with expert-judged risk classification according to the classifying, labelling and packaging (CLP) regulation. The most reliable results were obtained for carcinogenicity; however, less reliable predictions were derived for mutagenicity and reproductive toxicity. A group of compounds frequently predicted as false negatives was identified. These were relatively small molecules with low structural complexity, for example benzene derivatives with hydroxyl-, amino- or aniline-substituents. A rat liver S9 metabolite simulator was applied to illustrate the importance of considering metabolism in the risk assessment procedure. We also discuss outcome of combining predictions from multiple model systems and advise how to apply in silico tools. These models are proposed to be used to prioritise low-volume chemicals for testing within the REACH legislation, and we conclude that further guidance is needed so that industry can select and apply models in a reliable, systematic and transparent way.

  14. Advanced Computing Tools and Models for Accelerator Physics

    SciTech Connect

    Ryne, Robert; Ryne, Robert D.

    2008-06-11

    This paper is based on a transcript of my EPAC'08 presentation on advanced computing tools for accelerator physics. Following an introduction I present several examples, provide a history of the development of beam dynamics capabilities, and conclude with thoughts on the future of large scale computing in accelerator physics.

  15. Machine Tool Advanced Skills Technology Program (MAST). Overview and Methodology.

    ERIC Educational Resources Information Center

    Texas State Technical Coll., Waco.

    The Machine Tool Advanced Skills Technology Program (MAST) is a geographical partnership of six of the nation's best two-year colleges located in the six states that have about one-third of the density of metals-related industries in the United States. The purpose of the MAST grant is to develop and implement a national training model to overcome…

  16. Reaching Those Most in Need – A Call to Action for Advanced Parkinson’s Disease

    PubMed Central

    Agarwal, Shashank; Fleisher, Jori E

    2016-01-01

    Much of the clinical and research attention for Parkinson's Disease (PD) has focused on mild to moderate stages. As the disease advances, it can become difficult for patients to attend clinical visits. These patients are often lost to follow-up, and consequently, vanish from the pool of potential research subjects who could inform our management of this understudied population. We aim to increase awareness about this population and potential interventions to improve continuity of care and foster research in advanced PD. PMID:27708720

  17. Reaching Common Ground: Advancing Business Participation in Restructuring Education. Supporting Leaders for Tomorrow, Occasional Paper #6.

    ERIC Educational Resources Information Center

    Siegel, Peggy M.; Smoley, Eugene R., Jr.

    The differences and similarities between education and the private sector are analyzed as they both engage in efforts to fundamentally restructure their operations. To bridge the cultural gap between business and education, a workable strategy that advances direct and sustained private-sector involvement in education reform is proposed. Part 1 of…

  18. Advanced Technology Lifecycle Analysis System (ATLAS) Technology Tool Box (TTB)

    NASA Technical Reports Server (NTRS)

    Doyle, Monica; ONeil, Daniel A.; Christensen, Carissa B.

    2005-01-01

    The Advanced Technology Lifecycle Analysis System (ATLAS) is a decision support tool designed to aid program managers and strategic planners in determining how to invest technology research and development dollars. It is an Excel-based modeling package that allows a user to build complex space architectures and evaluate the impact of various technology choices. ATLAS contains system models, cost and operations models, a campaign timeline and a centralized technology database. Technology data for all system models is drawn from a common database, the ATLAS Technology Tool Box (TTB). The TTB provides a comprehensive, architecture-independent technology database that is keyed to current and future timeframes.

  19. Knowledge, Models and Tools in Support of Advanced Distance Learning

    DTIC Science & Technology

    2006-06-01

    authoring iRides simulations and training, Rivets , is a fast C++ program that has been compiled for three Unix-type operating systems: Linux, Silicon...School instructors to introduce core concepts of the tool in advance of teaching about expected value theory. 4.0 Rivets -Linux-based Authoring of...Simulations and Instruction Functioning versions of Rivets , a descendent of the classic RIDES program have been developed for Linux and for the Macintosh

  20. Bacteriophage-based tools: recent advances and novel applications

    PubMed Central

    O'Sullivan, Lisa; Buttimer, Colin; McAuliffe, Olivia; Bolton, Declan; Coffey, Aidan

    2016-01-01

    Bacteriophages (phages) are viruses that infect bacterial hosts, and since their discovery over a century ago they have been primarily exploited to control bacterial populations and to serve as tools in molecular biology. In this commentary, we highlight recent diverse advances in the field of phage research, going beyond bacterial control using whole phage, to areas including biocontrol using phage-derived enzybiotics, diagnostics, drug discovery, novel drug delivery systems and bionanotechnology. PMID:27990274

  1. Anvil Tool in the Advanced Weather Interactive Processing System

    NASA Technical Reports Server (NTRS)

    Barrett, Joe, III; Bauman, William, III; Keen, Jeremy

    2007-01-01

    Meteorologists from the 45th Weather Squadron (45 WS) and Spaceflight Meteorology Group (SMG) have identified anvil forecasting as one of their most challenging tasks when predicting the probability of violations of the lightning Launch Commit Criteria and Space Shuttle Flight Rules. As a result, the Applied Meteorology Unit (AMU) created a graphical overlay tool for the Meteorological Interactive Data Display Systems (MIDDS) to indicate the threat of thunderstorm anvil clouds, using either observed or model forecast winds as input. In order for the Anvil Tool to remain available to the meteorologists, the AMU was tasked to transition the tool to the Advanced Weather interactive Processing System (AWIPS). This report describes the work done by the AMU to develop the Anvil Tool for AWIPS to create a graphical overlay depicting the threat from thunderstorm anvil clouds. The AWIPS Anvil Tool is based on the previously deployed AMU MIDDS Anvil Tool. SMG and 45 WS forecasters have used the MIDDS Anvil Tool during launch and landing operations. SMG's primary weather analysis and display system is now AWIPS and the 45 WS has plans to replace MIDDS with AWIPS. The Anvil Tool creates a graphic that users can overlay on satellite or radar imagery to depict the potential location of thunderstorm anvils one, two, and three hours into the future. The locations are based on an average of the upper-level observed or forecasted winds. The graphic includes 10 and 20 nm standoff circles centered at the location of interest, in addition to one-, two-, and three-hour arcs in the upwind direction. The arcs extend outward across a 30 degree sector width based on a previous AMU study which determined thunderstorm anvils move in a direction plus or minus 15 degrees of the upper-level (300- to 150-mb) wind direction. This report briefly describes the history of the MIDDS Anvil Tool and then explains how the initial development of the AWIPS Anvil Tool was carried out. After testing was

  2. Advanced computational tools for 3-D seismic analysis

    SciTech Connect

    Barhen, J.; Glover, C.W.; Protopopescu, V.A.

    1996-06-01

    The global objective of this effort is to develop advanced computational tools for 3-D seismic analysis, and test the products using a model dataset developed under the joint aegis of the United States` Society of Exploration Geophysicists (SEG) and the European Association of Exploration Geophysicists (EAEG). The goal is to enhance the value to the oil industry of the SEG/EAEG modeling project, carried out with US Department of Energy (DOE) funding in FY` 93-95. The primary objective of the ORNL Center for Engineering Systems Advanced Research (CESAR) is to spearhead the computational innovations techniques that would enable a revolutionary advance in 3-D seismic analysis. The CESAR effort is carried out in collaboration with world-class domain experts from leading universities, and in close coordination with other national laboratories and oil industry partners.

  3. Evaluation of reliability modeling tools for advanced fault tolerant systems

    NASA Technical Reports Server (NTRS)

    Baker, Robert; Scheper, Charlotte

    1986-01-01

    The Computer Aided Reliability Estimation (CARE III) and Automated Reliability Interactice Estimation System (ARIES 82) reliability tools for application to advanced fault tolerance aerospace systems were evaluated. To determine reliability modeling requirements, the evaluation focused on the Draper Laboratories' Advanced Information Processing System (AIPS) architecture as an example architecture for fault tolerance aerospace systems. Advantages and limitations were identified for each reliability evaluation tool. The CARE III program was designed primarily for analyzing ultrareliable flight control systems. The ARIES 82 program's primary use was to support university research and teaching. Both CARE III and ARIES 82 were not suited for determining the reliability of complex nodal networks of the type used to interconnect processing sites in the AIPS architecture. It was concluded that ARIES was not suitable for modeling advanced fault tolerant systems. It was further concluded that subject to some limitations (the difficulty in modeling systems with unpowered spare modules, systems where equipment maintenance must be considered, systems where failure depends on the sequence in which faults occurred, and systems where multiple faults greater than a double near coincident faults must be considered), CARE III is best suited for evaluating the reliability of advanced tolerant systems for air transport.

  4. Anvil Forecast Tool in the Advanced Weather Interactive Processing System

    NASA Technical Reports Server (NTRS)

    Barrett, Joe H., III; Hood, Doris

    2009-01-01

    Meteorologists from the 45th Weather Squadron (45 WS) and National Weather Service Spaceflight Meteorology Group (SMG) have identified anvil forecasting as one of their most challenging tasks when predicting the probability of violations of the Lightning Launch Commit Criteria and Space Shuttle Flight Rules. As a result, the Applied Meteorology Unit (AMU) was tasked to create a graphical overlay tool for the Meteorological Interactive Data Display System (MIDDS) that indicates the threat of thunderstorm anvil clouds, using either observed or model forecast winds as input. The tool creates a graphic depicting the potential location of thunderstorm anvils one, two, and three hours into the future. The locations are based on the average of the upper level observed or forecasted winds. The graphic includes 10 and 20 n mi standoff circles centered at the location of interest, as well as one-, two-, and three-hour arcs in the upwind direction. The arcs extend outward across a 30 sector width based on a previous AMU study that determined thunderstorm anvils move in a direction plus or minus 15 of the upper-level wind direction. The AMU was then tasked to transition the tool to the Advanced Weather Interactive Processing System (AWIPS). SMG later requested the tool be updated to provide more flexibility and quicker access to model data. This presentation describes the work performed by the AMU to transition the tool into AWIPS, as well as the subsequent improvements made to the tool.

  5. [Advance directives in Italy: a goal not yet reached but already passed?].

    PubMed

    Riccioni, Luigi; Gristina, Giuseppe

    2015-10-01

    The advance directives (ADs) have been adopted in many countries to defend patients' autonomy. In Italy, in the past, this topic gave rise to a heated debate involving philosophers, theologians, and politicians. In 2009, the government presented a bill of law on ADs firmly criticized from a scientific, moral and juridical point of view because the bill's content is against the principles of Italian Constitution, Italian Code of Medical Ethics, Oviedo Convention, and official statements of many scientific societies. Although the bill has passed the Low Chamber it lies, even since, in the Senate, lacking in regard any agreement among the political parties. The purpose of this article is to highlight that, in our country, patients, relatives and doctors deserve a law not only related to the specific topic of ADs, but - as in other European countries (Germany, Spain, France, UK) - aimed to deal with the complex issue of end of life care as a whole. This law should take into account the sound evidence existing in regard to the four fundamental principles supporting the best scientific and ethical approaches to the end of life issues: shared decision making process between doctors and patients/relatives; rejection of dying process marked by the suffering; withholding/withdrawing futile treatments together with palliative sedation as two crucial contributions to suppress the patient suffering and pain; clear-cut difference between these clinical/ethical options and euthanasia. At the same time, this law should be able to provide physicians with a legal coverage to make all the clinical and ethical decisions more and more complex because of the continuous evolution of medical science on one hand, and the impressive development of biotechnology on the other hand.

  6. REACH-ER: a tool to evaluate river basin remediation measures for contaminants at the catchment scale

    NASA Astrophysics Data System (ADS)

    van Griensven, Ann; Haest, Pieter Jan; Broekx, Steven; Seuntjens, Piet; Campling, Paul; Ducos, Geraldine; Blaha, Ludek; Slobodnik, Jaroslav

    2010-05-01

    The European Union (EU) adopted the Water Framework Directive (WFD) in 2000 ensuring that all aquatic ecosystems meet ‘good status' by 2015. However, it is a major challenge for river basin managers to meet this requirement in river basins with a high population density as well as intensive agricultural and industrial activities. The EU financed AQUAREHAB project (FP7) specifically examines the ecological and economic impact of innovative rehabilitation technologies for multi-pressured degraded water bodies. For this purpose, a generic collaborative management toolREACH-ER' is being developed that can be used by stakeholders, citizens and water managers to evaluate the ecological and economical effects of different remedial actions on waterbodies. The tool is built using databases from large scale models simulating the hydrological dynamics of the river basing and sub-basins, the costs of the measures and the effectiveness of the measures in terms of ecological impact. Knowledge rules are used to describe the relationships between these data in order to compute the flux concentrations or to compute the effectiveness of measures. The management tool specifically addresses nitrate pollution and pollution by organic micropollutants. Detailed models are also used to predict the effectiveness of site remedial technologies using readily available global data. Rules describing ecological impacts are derived from ecotoxicological data for (mixtures of) specific contaminants (msPAF) and ecological indices relating effects to the presence of certain contaminants. Rules describing the cost-effectiveness of measures are derived from linear programming models identifying the least-cost combination of abatement measures to satisfy multi-pollutant reduction targets and from multi-criteria analysis.

  7. Advances in Mass Spectrometric Tools for Probing Neuropeptides

    NASA Astrophysics Data System (ADS)

    Buchberger, Amanda; Yu, Qing; Li, Lingjun

    2015-07-01

    Neuropeptides are important mediators in the functionality of the brain and other neurological organs. Because neuropeptides exist in a wide range of concentrations, appropriate characterization methods are needed to provide dynamic, chemical, and spatial information. Mass spectrometry and compatible tools have been a popular choice in analyzing neuropeptides. There have been several advances and challenges, both of which are the focus of this review. Discussions range from sample collection to bioinformatic tools, although avenues such as quantitation and imaging are included. Further development of the presented methods for neuropeptidomic mass spectrometric analysis is inevitable, which will lead to a further understanding of the complex interplay of neuropeptides and other signaling molecules in the nervous system.

  8. Advanced Electric Submersible Pump Design Tool for Geothermal Applications

    SciTech Connect

    Xuele Qi; Norman Turnquist; Farshad Ghasripoor

    2012-05-31

    Electrical Submersible Pumps (ESPs) present higher efficiency, larger production rate, and can be operated in deeper wells than the other geothermal artificial lifting systems. Enhanced Geothermal Systems (EGS) applications recommend lifting 300 C geothermal water at 80kg/s flow rate in a maximum 10-5/8-inch diameter wellbore to improve the cost-effectiveness. In this paper, an advanced ESP design tool comprising a 1D theoretical model and a 3D CFD analysis has been developed to design ESPs for geothermal applications. Design of Experiments was also performed to optimize the geometry and performance. The designed mixed-flow type centrifugal impeller and diffuser exhibit high efficiency and head rise under simulated EGS conditions. The design tool has been validated by comparing the prediction to experimental data of an existing ESP product.

  9. Constructing an advanced software tool for planetary atmospheric modeling

    NASA Technical Reports Server (NTRS)

    Keller, Richard M.; Sims, Michael; Podolak, Ester; Mckay, Christopher

    1990-01-01

    Scientific model building can be an intensive and painstaking process, often involving the development of large and complex computer programs. Despite the effort involved, scientific models cannot be easily distributed and shared with other scientists. In general, implemented scientific models are complex, idiosyncratic, and difficult for anyone but the original scientist/programmer to understand. We believe that advanced software techniques can facilitate both the model building and model sharing process. In this paper, we describe a prototype for a scientific modeling software tool that serves as an aid to the scientist in developing and using models. This tool includes an interactive intelligent graphical interface, a high level domain specific modeling language, a library of physics equations and experimental datasets, and a suite of data display facilities. Our prototype has been developed in the domain of planetary atmospheric modeling, and is being used to construct models of Titan's atmosphere.

  10. Review on advanced composite materials boring mechanism and tools

    NASA Astrophysics Data System (ADS)

    Shi, Runping; Wang, Chengyong

    2011-05-01

    With the rapid development of aviation and aerospace manufacturing technology, advanced composite materials represented by carbon fibre reinforced plastics (CFRP) and super hybrid composites (fibre/metal plates) are more and more widely applied. The fibres are mainly carbon fibre, boron fibre, Aramid fiber and Sic fibre. The matrixes are resin matrix, metal matrix and ceramic matrix. Advanced composite materials have higher specific strength and higher specific modulus than glass fibre reinforced resin composites of the 1st generation. They are widely used in aviation and aerospace industry due to their high specific strength, high specific modulus, excellent ductility, anticorrosion, heat-insulation, sound-insulation, shock absorption and high&low temperature resistance. They are used for radomes, inlets, airfoils(fuel tank included), flap, aileron, vertical tail, horizontal tail, air brake, skin, baseboards and tails, etc. Its hardness is up to 62~65HRC. The holes are greatly affected by the fibre laminates direction of carbon fibre reinforced composite material due to its anisotropy when drilling in unidirectional laminates. There are burrs, splits at the exit because of stress concentration. Besides there is delamination and the hole is prone to be smaller. Burrs are caused by poor sharpness of cutting edge, delamination, tearing, splitting are caused by the great stress caused by high thrust force. Poorer sharpness of cutting edge leads to lower cutting performance and higher drilling force at the same time. The present research focuses on the interrelation between rotation speed, feed, drill's geometry, drill life, cutting mode, tools material etc. and thrust force. At the same time, holes quantity and holes making difficulty of composites have also increased. It requires high performance drills which won't bring out defects and have long tool life. It has become a trend to develop super hard material tools and tools with special geometry for drilling

  11. Review on advanced composite materials boring mechanism and tools

    NASA Astrophysics Data System (ADS)

    Shi, Runping; Wang, Chengyong

    2010-12-01

    With the rapid development of aviation and aerospace manufacturing technology, advanced composite materials represented by carbon fibre reinforced plastics (CFRP) and super hybrid composites (fibre/metal plates) are more and more widely applied. The fibres are mainly carbon fibre, boron fibre, Aramid fiber and Sic fibre. The matrixes are resin matrix, metal matrix and ceramic matrix. Advanced composite materials have higher specific strength and higher specific modulus than glass fibre reinforced resin composites of the 1st generation. They are widely used in aviation and aerospace industry due to their high specific strength, high specific modulus, excellent ductility, anticorrosion, heat-insulation, sound-insulation, shock absorption and high&low temperature resistance. They are used for radomes, inlets, airfoils(fuel tank included), flap, aileron, vertical tail, horizontal tail, air brake, skin, baseboards and tails, etc. Its hardness is up to 62~65HRC. The holes are greatly affected by the fibre laminates direction of carbon fibre reinforced composite material due to its anisotropy when drilling in unidirectional laminates. There are burrs, splits at the exit because of stress concentration. Besides there is delamination and the hole is prone to be smaller. Burrs are caused by poor sharpness of cutting edge, delamination, tearing, splitting are caused by the great stress caused by high thrust force. Poorer sharpness of cutting edge leads to lower cutting performance and higher drilling force at the same time. The present research focuses on the interrelation between rotation speed, feed, drill's geometry, drill life, cutting mode, tools material etc. and thrust force. At the same time, holes quantity and holes making difficulty of composites have also increased. It requires high performance drills which won't bring out defects and have long tool life. It has become a trend to develop super hard material tools and tools with special geometry for drilling

  12. Simulated Interactive Research Experiments as Educational Tools for Advanced Science.

    PubMed

    Tomandl, Mathias; Mieling, Thomas; Losert-Valiente Kroon, Christiane M; Hopf, Martin; Arndt, Markus

    2015-09-15

    Experimental research has become complex and thus a challenge to science education. Only very few students can typically be trained on advanced scientific equipment. It is therefore important to find new tools that allow all students to acquire laboratory skills individually and independent of where they are located. In a design-based research process we have investigated the feasibility of using a virtual laboratory as a photo-realistic and scientifically valid representation of advanced scientific infrastructure to teach modern experimental science, here, molecular quantum optics. We found a concept based on three educational principles that allows undergraduate students to become acquainted with procedures and concepts of a modern research field. We find a significant increase in student understanding using our Simulated Interactive Research Experiment (SiReX), by evaluating the learning outcomes with semi-structured interviews in a pre/post design. This suggests that this concept of an educational tool can be generalized to disseminate findings in other fields.

  13. Simulated Interactive Research Experiments as Educational Tools for Advanced Science

    PubMed Central

    Tomandl, Mathias; Mieling, Thomas; Losert-Valiente Kroon, Christiane M.; Hopf, Martin; Arndt, Markus

    2015-01-01

    Experimental research has become complex and thus a challenge to science education. Only very few students can typically be trained on advanced scientific equipment. It is therefore important to find new tools that allow all students to acquire laboratory skills individually and independent of where they are located. In a design-based research process we have investigated the feasibility of using a virtual laboratory as a photo-realistic and scientifically valid representation of advanced scientific infrastructure to teach modern experimental science, here, molecular quantum optics. We found a concept based on three educational principles that allows undergraduate students to become acquainted with procedures and concepts of a modern research field. We find a significant increase in student understanding using our Simulated Interactive Research Experiment (SiReX), by evaluating the learning outcomes with semi-structured interviews in a pre/post design. This suggests that this concept of an educational tool can be generalized to disseminate findings in other fields. PMID:26370627

  14. ADVISOR: a systems analysis tool for advanced vehicle modeling

    NASA Astrophysics Data System (ADS)

    Markel, T.; Brooker, A.; Hendricks, T.; Johnson, V.; Kelly, K.; Kramer, B.; O'Keefe, M.; Sprik, S.; Wipke, K.

    This paper provides an overview of Advanced Vehicle Simulator (ADVISOR)—the US Department of Energy's (DOE's) ADVISOR written in the MATLAB/Simulink environment and developed by the National Renewable Energy Laboratory. ADVISOR provides the vehicle engineering community with an easy-to-use, flexible, yet robust and supported analysis package for advanced vehicle modeling. It is primarily used to quantify the fuel economy, the performance, and the emissions of vehicles that use alternative technologies including fuel cells, batteries, electric motors, and internal combustion engines in hybrid (i.e. multiple power sources) configurations. It excels at quantifying the relative change that can be expected due to the implementation of technology compared to a baseline scenario. ADVISOR's capabilities and limitations are presented and the power source models that are included in ADVISOR are discussed. Finally, several applications of the tool are presented to highlight ADVISOR's functionality. The content of this paper is based on a presentation made at the 'Development of Advanced Battery Engineering Models' workshop held in Crystal City, Virginia in August 2001.

  15. Bioinformatics Methods and Tools to Advance Clinical Care

    PubMed Central

    Lecroq, T.

    2015-01-01

    Summary Objectives To summarize excellent current research in the field of Bioinformatics and Translational Informatics with application in the health domain and clinical care. Method We provide a synopsis of the articles selected for the IMIA Yearbook 2015, from which we attempt to derive a synthetic overview of current and future activities in the field. As last year, a first step of selection was performed by querying MEDLINE with a list of MeSH descriptors completed by a list of terms adapted to the section. Each section editor has evaluated separately the set of 1,594 articles and the evaluation results were merged for retaining 15 articles for peer-review. Results The selection and evaluation process of this Yearbook’s section on Bioinformatics and Translational Informatics yielded four excellent articles regarding data management and genome medicine that are mainly tool-based papers. In the first article, the authors present PPISURV a tool for uncovering the role of specific genes in cancer survival outcome. The second article describes the classifier PredictSNP which combines six performing tools for predicting disease-related mutations. In the third article, by presenting a high-coverage map of the human proteome using high resolution mass spectrometry, the authors highlight the need for using mass spectrometry to complement genome annotation. The fourth article is also related to patient survival and decision support. The authors present datamining methods of large-scale datasets of past transplants. The objective is to identify chances of survival. Conclusions The current research activities still attest the continuous convergence of Bioinformatics and Medical Informatics, with a focus this year on dedicated tools and methods to advance clinical care. Indeed, there is a need for powerful tools for managing and interpreting complex, large-scale genomic and biological datasets, but also a need for user-friendly tools developed for the clinicians in their

  16. Clinical holistic health: advanced tools for holistic medicine.

    PubMed

    Ventegodt, Søren; Clausen, Birgitte; Nielsen, May Lyck; Merrick, Joav

    2006-02-24

    According to holistic medical theory, the patient will heal when old painful moments, the traumatic events of life that are often called "gestalts", are integrated in the present "now". The advanced holistic physician's expanded toolbox has many different tools to induce this healing, some that are more dangerous and potentially traumatic than others. The more intense the therapeutic technique, the more emotional energy will be released and contained in the session, but the higher also is the risk for the therapist to lose control of the session and lose the patient to his or her own dark side. To avoid harming the patient must be the highest priority in holistic existential therapy, making sufficient education and training an issue of highest importance. The concept of "stepping up" the therapy by using more and more "dramatic" methods to get access to repressed emotions and events has led us to a "therapeutic staircase" with ten steps: (1) establishing the relationship; (2) establishing intimacy, trust, and confidentiality; (3) giving support and holding; (4) taking the patient into the process of physical, emotional, and mental healing; (5) social healing of being in the family; (6) spiritual healing--returning to the abstract wholeness of the soul; (7) healing the informational layer of the body; (8) healing the three fundamental dimensions of existence: love, power, and sexuality in a direct way using, among other techniques, "controlled violence" and "acupressure through the vagina"; (9) mind-expanding and consciousness-transformative techniques like psychotropic drugs; and (10) techniques transgressing the patient's borders and, therefore, often traumatizing (for instance, the use of force against the will of the patient). We believe that the systematic use of the staircase will greatly improve the power and efficiency of holistic medicine for the patient and we invite a broad cooperation in scientifically testing the efficiency of the advanced holistic

  17. Advanced Tools and Techniques for Formal Techniques in Aerospace Systems

    NASA Technical Reports Server (NTRS)

    Knight, John C.

    2005-01-01

    This is the final technical report for grant number NAG-1-02101. The title of this grant was "Advanced Tools and Techniques for Formal Techniques In Aerospace Systems". The principal investigator on this grant was Dr. John C. Knight of the Computer Science Department, University of Virginia, Charlottesville, Virginia 22904-4740. This report summarizes activities under the grant during the period 7/01/2002 to 9/30/2004. This report is organized as follows. In section 2, the technical background of the grant is summarized. Section 3 lists accomplishments and section 4 lists students funded under the grant. In section 5, we present a list of presentations given at various academic and research institutions about the research conducted. Finally, a list of publications generated under this grant is included in section 6.

  18. Sandia Advanced MEMS Design Tools, Version 2.0

    SciTech Connect

    Allen, Jim; McBrayer, John; Miller, Sam; Rodgers, Steve; montague, Steve; Sniegowski, Jeff; Jakubczak, Jay; Yarberry, Vic; Barnes, Steve; Priddy, Brian; Reyes, David; Westling, Belinda

    2002-06-13

    Sandia Advanced MEMS Design Tools is a 5-level surface micromachine fabrication technology, which customers internal and external to Sandia can access to fabricate prototype MEMS devices. This CD contains an integrated set of electronic files that: a) Describe the SUMMiT V fabrication process b) Provide enabling educational information (including pictures, videos, technical information) c)Facilitate the process of designing MEMS with the SUMMiT process (prototype file, Design Rule Checker, Standard Parts Library) d) Facilitate the process of having MEMS fabricated at SNL e) Facilitate the process of having post-fabrication services performed While there exist some files on the CD that are used in conjunction with the software AutoCAD, these files are not intended for use independent of the CD. NOTE: THE CUSTOMER MUST PURCHASE HIS/HER OWN COPY OF AutoCAD TO USE WITH THESE FILES.

  19. Sandia Advanced MEMS Design Tools v. 3.0

    SciTech Connect

    Yarberry, Victor R.; Allen, James J.; Lantz, Jeffrey W.; Priddy, Brian; Westlin, Belinda; Young, Andrew

    2016-08-25

    This is a major revision to the Sandia Advanced MEMS Design Tools. It replaces all previous versions. New features in this version: Revised to support AutoCAD 2014 and 2015 This CD contains an integrated set of electronic files that: a) Describe the SUMMiT V fabrication process b) Provide enabling educational information (including pictures, videos, technical information) c) Facilitate the process of designing MEMS with the SUMMiT process (prototype file, Design Rule Checker, Standard Parts Library) d) Facilitate the process of having MEMS fabricated at Sandia National Laboratories e) Facilitate the process of having post-fabrication services performed. While there exists some files on the CD that are used in conjunction with software package AutoCAD, these files are not intended for use independent of the CD. Note that the customer must purchase his/her own copy of AutoCAD to use with these files.

  20. Tool for Sizing Analysis of the Advanced Life Support System

    NASA Technical Reports Server (NTRS)

    Yeh, Hue-Hsie Jannivine; Brown, Cheryl B.; Jeng, Frank J.

    2005-01-01

    Advanced Life Support Sizing Analysis Tool (ALSSAT) is a computer model for sizing and analyzing designs of environmental-control and life support systems (ECLSS) for spacecraft and surface habitats involved in the exploration of Mars and Moon. It performs conceptual designs of advanced life support (ALS) subsystems that utilize physicochemical and biological processes to recycle air and water, and process wastes in order to reduce the need of resource resupply. By assuming steady-state operations, ALSSAT is a means of investigating combinations of such subsystems technologies and thereby assisting in determining the most cost-effective technology combination available. In fact, ALSSAT can perform sizing analysis of the ALS subsystems that are operated dynamically or steady in nature. Using the Microsoft Excel spreadsheet software with Visual Basic programming language, ALSSAT has been developed to perform multiple-case trade studies based on the calculated ECLSS mass, volume, power, and Equivalent System Mass, as well as parametric studies by varying the input parameters. ALSSAT s modular format is specifically designed for the ease of future maintenance and upgrades.

  1. Sandia Advanced MEMS Design Tools, Version 2.2.5

    SciTech Connect

    Yarberry, Victor; Allen, James; Lantz, Jeffery; Priddy, Brian; & Westling, Belinda

    2010-01-19

    The Sandia National Laboratories Advanced MEMS Design Tools, Version 2.2.5, is a collection of menus, prototype drawings, and executables that provide significant productivity enhancements when using AutoCAD to design MEMS components. This release is designed for AutoCAD 2000i, 2002, or 2004 and is supported under Windows NT 4.0, Windows 2000, or XP. SUMMiT V (Sandia Ultra planar Multi level MEMS Technology) is a 5 level surface micromachine fabrication technology, which customers internal and external to Sandia can access to fabricate prototype MEMS devices. This CD contains an integrated set of electronic files that: a) Describe the SUMMiT V fabrication process b) Facilitate the process of designing MEMS with the SUMMiT process (prototype file, Design Rule Checker, Standard Parts Library) New features in this version: AutoCAD 2004 support has been added. SafeExplode ? a new feature that explodes blocks without affecting polylines (avoids exploding polylines into objects that are ignored by the DRC and Visualization tools). Layer control menu ? a pull-down menu for selecting layers to isolate, freeze, or thaw. Updated tools: A check has been added to catch invalid block names. DRC features: Added username/password validation, added a method to update the user?s password. SNL_DRC_WIDTH ? a value to control the width of the DRC error lines. SNL_BIAS_VALUE ? a value use to offset selected geometry SNL_PROCESS_NAME ? a value to specify the process name Documentation changes: The documentation has been updated to include the new features. While there exist some files on the CD that are used in conjunction with software package AutoCAD, these files are not intended for use independent of the CD. Note that the customer must purchase his/her own copy of AutoCAD to use with these files.

  2. Advanced Infusion Techniques with 3-D Printed Tooling

    SciTech Connect

    Nuttall, David; Elliott, Amy; Post, Brian K.; Love, Lonnie J.

    2016-05-10

    The manufacturing of tooling for large, contoured surfaces for fiber-layup applications requires significant effort to understand the geometry and then to subtractively manufacture the tool. Traditional methods for the auto industry use clay that is hand sculpted. In the marine pleasure craft industry, the exterior of the model is formed from a foam lay-up that is either hand cut or machined to create smooth lines. Engineers and researchers at Oak Ridge National Laboratory s Manufacturing Demonstration Facility (ORNL MDF) collaborated with Magnum Venus Products (MVP) in the development of a process for reproducing legacy whitewater adventure craft via digital scanning and large scale 3-D printed layup molds. The process entailed 3D scanning a legacy canoe form, converting that form to a CAD model, additively manufacturing (3-D Print) the mold tool, and subtractively finishing the mold s transfer surfaces. Future work will include applying a gelcoat to the mold transfer surface and infusing using vacuum assisted resin transfer molding, or VARTM principles, to create a watertight vessel. The outlined steps were performed on a specific canoe geometry found by MVP s principal participant. The intent of utilizing this geometry is to develop an energy efficient and marketable process for replicating complex shapes, specifically focusing on this particular watercraft, and provide a finished product for demonstration to the composites industry. The culminating part produced through this agreement has been slated for public presentation and potential demonstration at the 2016 CAMX (Composites and Advanced Materials eXpo) exposition in Anaheim, CA. Phase I of this collaborative research and development agreement (MDF-15-68) was conducted under CRADA NFE-15-05575 and was initiated on May 7, 2015, with an introduction to the MVP product line, and concluded in March of 2016 with the printing of and processing of a canoe mold. The project partner Magnum Venous Products (MVP) is

  3. The scientific modeling assistant: An advanced software tool for scientific model building

    NASA Technical Reports Server (NTRS)

    Keller, Richard M.; Sims, Michael H.

    1991-01-01

    Viewgraphs on the scientific modeling assistant: an advanced software tool for scientific model building are presented. The objective is to build a specialized software tool to assist in scientific model-building.

  4. Functional toxicology: tools to advance the future of toxicity testing

    PubMed Central

    Gaytán, Brandon D.; Vulpe, Chris D.

    2014-01-01

    The increased presence of chemical contaminants in the environment is an undeniable concern to human health and ecosystems. Historically, by relying heavily upon costly and laborious animal-based toxicity assays, the field of toxicology has often neglected examinations of the cellular and molecular mechanisms of toxicity for the majority of compounds—information that, if available, would strengthen risk assessment analyses. Functional toxicology, where cells or organisms with gene deletions or depleted proteins are used to assess genetic requirements for chemical tolerance, can advance the field of toxicity testing by contributing data regarding chemical mechanisms of toxicity. Functional toxicology can be accomplished using available genetic tools in yeasts, other fungi and bacteria, and eukaryotes of increased complexity, including zebrafish, fruit flies, rodents, and human cell lines. Underscored is the value of using less complex systems such as yeasts to direct further studies in more complex systems such as human cell lines. Functional techniques can yield (1) novel insights into chemical toxicity; (2) pathways and mechanisms deserving of further study; and (3) candidate human toxicant susceptibility or resistance genes. PMID:24847352

  5. Second-line ramucirumab therapy for advanced hepatocellular carcinoma (REACH): an East Asian and non-East Asian subgroup analysis

    PubMed Central

    Park, Joon Oh; Ryoo, Baek-Yeol; Yen, Chia-Jui; Kudo, Masatoshi; Yang, Ling; Abada, Paolo B.; Cheng, Rebecca; Orlando, Mauro; Zhu, Andrew X.; Okusaka, Takuji

    2016-01-01

    Purpose REACH investigated second-line ramucirumab therapy for advanced hepatocellular carcinoma. Results Median overall survival was 8.2 months for ramucirumab and 6.9 months for placebo (HR, 0.835; 95% CI, 0.634–1.100; p = 0.2046) for East Asians, and 10.1 months for ramucirumab and 8.0 months for placebo (HR, 0.895; 95% CI, 0.690–1.161; p = 0.4023) for non-East Asians. Median overall survival in patients with baseline alpha-fetoprotein ≥ 400 ng/mL was 7.8 months for ramucirumab and 4.2 months for placebo (HR, 0.749; 95% CI, 0.519–1.082; p = 0.1213) for East Asians (n = 139), and 8.2 months for ramucirumab and 4.5 months for placebo (HR, 0.579; 95% CI, 0.371–0.904; p = 0.0149) for non-East Asians (n = 111). The most common grade ≥ 3 treatment-emergent adverse events in East Asians and non-East Asians included hypertension and malignant neoplasm progression. Materials and methods A post-hoc analysis of East Asians (N = 252) and non-East Asians (N = 313) in the intent-to-treat population was performed. Conclusions In East Asians and non-East Asians, ramucirumab did not significantly prolong overall survival. In patients with baseline alpha-fetoprotein ≥ 400 ng/mL, a potentially larger survival benefit was observed in both subgroups. Safety for East Asians was similar to non-East Asians. PMID:27776351

  6. STRING 3: An Advanced Groundwater Flow Visualization Tool

    NASA Astrophysics Data System (ADS)

    Schröder, Simon; Michel, Isabel; Biedert, Tim; Gräfe, Marius; Seidel, Torsten; König, Christoph

    2016-04-01

    The visualization of 3D groundwater flow is a challenging task. Previous versions of our software STRING [1] solely focused on intuitive visualization of complex flow scenarios for non-professional audiences. STRING, developed by Fraunhofer ITWM (Kaiserslautern, Germany) and delta h Ingenieurgesellschaft mbH (Witten, Germany), provides the necessary means for visualization of both 2D and 3D data on planar and curved surfaces. In this contribution we discuss how to extend this approach to a full 3D tool and its challenges in continuation of Michel et al. [2]. This elevates STRING from a post-production to an exploration tool for experts. In STRING moving pathlets provide an intuition of velocity and direction of both steady-state and transient flows. The visualization concept is based on the Lagrangian view of the flow. To capture every detail of the flow an advanced method for intelligent, time-dependent seeding is used building on the Finite Pointset Method (FPM) developed by Fraunhofer ITWM. Lifting our visualization approach from 2D into 3D provides many new challenges. With the implementation of a seeding strategy for 3D one of the major problems has already been solved (see Schröder et al. [3]). As pathlets only provide an overview of the velocity field other means are required for the visualization of additional flow properties. We suggest the use of Direct Volume Rendering and isosurfaces for scalar features. In this regard we were able to develop an efficient approach for combining the rendering through raytracing of the volume and regular OpenGL geometries. This is achieved through the use of Depth Peeling or A-Buffers for the rendering of transparent geometries. Animation of pathlets requires a strict boundary of the simulation domain. Hence, STRING needs to extract the boundary, even from unstructured data, if it is not provided. In 3D we additionally need a good visualization of the boundary itself. For this the silhouette based on the angle of

  7. Developing a Web-Based Tool Using Information and Communication Technologies to Expand the Reach and Impact of Photovoice

    ERIC Educational Resources Information Center

    Strack, Robert W.; Orsini, Muhsin Michael; Fearnow-Kenney, Melodie; Herget, Jennifer; Milroy, Jeffrey J.; Wyrick, David L.

    2015-01-01

    Information and communication technologies are opening up vast new arenas for conducting the work of health promotion. Technology-based health promotions expand reach, standardize information and its delivery, provide opportunities for tailoring, create engaging interactivity within content delivery, provide for privacy and autonomy, improve…

  8. Advanced Fuel Cycle Economic Tools, Algorithms, and Methodologies

    SciTech Connect

    David E. Shropshire

    2009-05-01

    The Advanced Fuel Cycle Initiative (AFCI) Systems Analysis supports engineering economic analyses and trade-studies, and requires a requisite reference cost basis to support adequate analysis rigor. In this regard, the AFCI program has created a reference set of economic documentation. The documentation consists of the “Advanced Fuel Cycle (AFC) Cost Basis” report (Shropshire, et al. 2007), “AFCI Economic Analysis” report, and the “AFCI Economic Tools, Algorithms, and Methodologies Report.” Together, these documents provide the reference cost basis, cost modeling basis, and methodologies needed to support AFCI economic analysis. The application of the reference cost data in the cost and econometric systems analysis models will be supported by this report. These methodologies include: the energy/environment/economic evaluation of nuclear technology penetration in the energy market—domestic and internationally—and impacts on AFCI facility deployment, uranium resource modeling to inform the front-end fuel cycle costs, facility first-of-a-kind to nth-of-a-kind learning with application to deployment of AFCI facilities, cost tradeoffs to meet nuclear non-proliferation requirements, and international nuclear facility supply/demand analysis. The economic analysis will be performed using two cost models. VISION.ECON will be used to evaluate and compare costs under dynamic conditions, consistent with the cases and analysis performed by the AFCI Systems Analysis team. Generation IV Excel Calculations of Nuclear Systems (G4-ECONS) will provide static (snapshot-in-time) cost analysis and will provide a check on the dynamic results. In future analysis, additional AFCI measures may be developed to show the value of AFCI in closing the fuel cycle. Comparisons can show AFCI in terms of reduced global proliferation (e.g., reduction in enrichment), greater sustainability through preservation of a natural resource (e.g., reduction in uranium ore depletion), value from

  9. Comparing Simple and Advanced Video Tools as Supports for Complex Collaborative Design Processes

    ERIC Educational Resources Information Center

    Zahn, Carmen; Pea, Roy; Hesse, Friedrich W.; Rosen, Joe

    2010-01-01

    Working with digital video technologies, particularly advanced video tools with editing capabilities, offers new prospects for meaningful learning through design. However, it is also possible that the additional complexity of such tools does "not" advance learning. We compared in an experiment the design processes and learning outcomes…

  10. Effectiveness of the Integration of ICT Tools and Activities to Foster Awareness as the First Stage to Reach Learning Autonomy

    ERIC Educational Resources Information Center

    Ariza, Andrea; Sánchez, Mario Suárez

    2013-01-01

    This article presents an action research study which integrated activities within two core subjects during one academic semester with first semester English language students. The students were guided through decision making, independent practice, and the development of metacognitive processes to study English using ICT tools. They were also…

  11. New advanced radio diagnostics tools for Space Weather Program

    NASA Astrophysics Data System (ADS)

    Krankowski, A.; Rothkaehl, H.; Atamaniuk, B.; Morawski, M.; Zakharenkova, I.; Cherniak, I.; Otmianowska-Mazur, K.

    2013-12-01

    To give a more detailed and complete understanding of physical plasma processes that govern the solar-terrestrial space, and to develop qualitative and quantitative models of the magnetosphere-ionosphere-thermosphere coupling, it is necessary to design and build the next generation of instruments for space diagnostics and monitoring. Novel ground- based wide-area sensor networks, such as the LOFAR (Low Frequency Array) radar facility, comprising wide band, and vector-sensing radio receivers and multi-spacecraft plasma diagnostics should help solve outstanding problems of space physics and describe long-term environmental changes. The LOw Frequency ARray - LOFAR - is a new fully digital radio telescope designed for frequencies between 30 MHz and 240 MHz located in Europe. The three new LOFAR stations will be installed until summer 2015 in Poland. The LOFAR facilities in Poland will be distributed among three sites: Lazy (East of Krakow), Borowiec near Poznan and Baldy near Olsztyn. All they will be connected via PIONIER dedicated links to Poznan. Each site will host one LOFAR station (96 high-band+96 low-band antennas). They will most time work as a part of European network, however, when less charged, they can operate as a national network The new digital radio frequency analyzer (RFA) on board the low-orbiting RELEC satellite was designed to monitor and investigate the ionospheric plasma properties. This two-point ground-based and topside ionosphere-located space plasma diagnostic can be a useful new tool for monitoring and diagnosing turbulent plasma properties. The RFA on board the RELEC satellite is the first in a series of experiments which is planned to be launched into the near-Earth environment. In order to improve and validate the large scales and small scales ionospheric structures we will used the GPS observations collected at IGS/EPN network employed to reconstruct diurnal variations of TEC using all satellite passes over individual GPS stations and the

  12. Gross motor development and reach on sound as critical tools for the development of the blind child.

    PubMed

    Elisa, Fazzi; Josée, Lanners; Oreste, Ferrari-Ginevra; Claudia, Achille; Antonella, Luparia; Sabrina, Signorini; Giovanni, Lanzi

    2002-08-01

    The aim of the study was to assess early neuromotor development in 20 congenitally blind or severely visually impaired children, nine without (B) and 11 with associated handicaps (B + H), in order to develop a strategy for early intervention in these subjects. The mean age at first observation was 11.4 months (range: 4-30 months). The mean follow-up duration was 16.9 months (range: 3-36 months). Assessment included developmental history, neurological examination, video-recording of spontaneous activity and administration of the Reynell-Zinkin Scales and neuroradiological and neurophysiological investigations. All B children walked independently (mean age 19.8 months) and 55.5% crawled (mean age 15 months); the B + H subjects displayed absence of almost all neuromotor functions, except one who walked at 20 months. All the B and just one (9%) of the B + H children developed satisfactory fine motor abilities. 'Reach on sound' at distance was achieved by all the B children by the age of 14.2 months while in the B + H group it was achieved by only two subjects at a median age of 19.5 months. We conclude that it is possible to describe the profile of neuromotor development in B and B + H children; strategies to help postural-motor development and 'reach on sound' appear to be fundamental in early intervention in these subjects.

  13. Reaching the Next Stephen Hawking: Five Ways to Help Students with Disabilities in Advanced Placement Science Classes

    ERIC Educational Resources Information Center

    Howard, Lori A.; Potts, Elizabeth A.; Linz, Ed

    2013-01-01

    As the federal government encourages all students to attempt advanced math and science courses, more students with disabilities are enrolling in Advanced Placement (AP) science classes. AP science teachers can better serve these students by understanding the various types of disabilities (whether physical, learning, emotional, or behavioral),…

  14. Development of rotational movements, hand shaping, and accuracy in advance and withdrawal for the reach-to-eat movement in human infants aged 6-12 months.

    PubMed

    Sacrey, Lori-Ann R; Karl, Jenni M; Whishaw, Ian Q

    2012-06-01

    The reach-to-eat movement, transport of a hand to grasp an object that is withdrawn and placed in the mouth, is amongst the earliest developing functional movements of human infants. The present longitudinal study is the first description of the maturation of hand-rotation, hand shaping, and accuracy associated with the advance and withdrawal phases of the movement. Eight infants, aged 6-12 months, and eight adults, were video recorded as they reached for familiar objects or food items. Hand, arm, and trunk movements were assessed frame-by-frame with the Skilled Reaching Rating Scale, previously developed for the assessment of adult reaching, and supplementary kinematic analysis. Reach-to-eat maturation was characterized by three changes. First, for advance, a simple open hand transport gradually matured to a movement associated with pronation and hand shaping of the digits for precision grasping. Second, for withdrawal to the mouth, a direct withdrawal movement gradually became associated with hand supination that oriented the target object to the mouth. Third, associated with the maturation of rotational movements, inaccurate and fragmented hand transport and withdrawal movements developed into precise targeting of the hand-to-object and object-to-mouth. Across the age range, there was a decrease in bimanual reaching and an increase in right handed reaching. The results are discussed in relation to the idea that the maturation of the reach-to-eat movement involves the development of rotational and shaping movements of the hand and visual and somatosensory guidance of a preferred hand.

  15. Constructing an advanced software tool for planetary atmospheric modeling

    NASA Technical Reports Server (NTRS)

    Keller, Richard M.; Sims, Michael H.; Podolak, Esther; Mckay, Christopher P.

    1990-01-01

    A prototype is described that can serve as a scientific-modeling software tool to facilitate the development of useful scientific models. The prototype is developed for applications to planetary modeling, and specific examples are given that relate to the atmosphere of Titan. The scientific modeling tool employs a high-level domain-specific modeling language, several data-display facilities, and a library of experimental datasets and scientific equations. The planetary modeling prototype links uncomputed physical variables to computed variables with computational transformations based on a backchaining procedure. The system - implemented in LISP with an object-oriented knowledge-representation tool - is run on a workstation that provides interface with several models. The prototype is expected to form the basis for a sophisticated modeling tool that can permit active experimentation.

  16. Graphic Novels: A New Stress Mitigation Tool for Military Training: Developing Content for Hard-to-Reach Audiences.

    PubMed

    Hourani, Laurel; Lambert, Shari; Peeler, Russ; Lane, Becky; Borst, Carrie

    2017-05-01

    This article describes the development of two graphic novels as a new approach to mental health communication and coping strategies for the Navy and Marine Corps. The novels are intended to capture the attention of the younger target audience and provide vital teaching messages to better prepare personnel for deployment to combat zones. The novels were developed based on embedding the principles of combat and operational stress control (COSC) into realistic and relatable characters, stories, and images. Approaches used for development included (a) basing storylines on real-life service members and the situations they face in combat and their personal lives; (b) partnering with COSC experts to embed teaching points; (c) ensuring technical accuracy through research and target audience reviews of the storyboard and artwork; (d) developing characters that are representative of the target audience, with varied jobs, ages, backgrounds, and professional concerns; and (e) designing artwork in a manner sensitive to training objectives and the psychological effects on readers. Because technical accuracy, realism, and sensitivity were noted as essential components of an effective graphic novel tool, focus-group research and review of author drafts by the target audience and technical experts are strongly recommended.

  17. The Internet as recruitment tool for HIV studies: viable strategy for reaching at-risk Hispanic MSM in Miami?

    PubMed

    Fernández, M I; Varga, L M; Perrino, T; Collazo, J B; Subiaul, F; Rehbein, A; Torres, H; Castro, M; Bowen, G S

    2004-11-01

    Although use of the Internet as a vehicle for HIV/STI research is increasing, its viability to recruit at-risk populations such as Hispanic men who have sex with men (HMSM) to participate in community-based HIV studies is in its infancy. We report on the first 171 participants enrolled in an ongoing study exploring use of the Internet to recruit Hispanic men who have sex with men (HMSM) living in Miami-Dade County, Florida to participate in community-based studies. We report our initial success with chat-room recruitment and describe the sexual and drug use practices of the initial set of participants who were recruited through the Internet. In addition, we describe the formative work conducted to develop the Internet recruitment procedures we are testing. In two months, we spent 211 hours recruiting in chat-rooms and engaged 735 chatters. One hundred and seventy-six men came to our community sites; 172 (98%) were eligible and completed an audio computer-assisted self-interview. In the previous six months, 94.7% of participants had anal sex; 48.9% did not use condoms for anal sex or used them inconsistently; and 48.5% had used club drugs. Six-month use rates for individual drugs were: poppers (31.6%), cocaine (15.8%), ecstasy (14%) and crystal methamphetamines (11.7%). Use of club drugs was significantly associated with unprotected insertive and unprotected receptive anal sex. These initial findings point to the Internet's potential as a tool for recruiting at-risk Hispanic MSM for community studies.

  18. XML based tools for assessing potential impact of advanced technology space validation

    NASA Technical Reports Server (NTRS)

    Some, Raphael R.; Weisbin, Charles

    2004-01-01

    A hierarchical XML database and related analysis tools are being developed by the New Millennium Program to provide guidance on the relative impact, to future NASA missions, of advanced technologies under consideration for developmental funding.

  19. Human Factors Evaluation of Advanced Electric Power Grid Visualization Tools

    SciTech Connect

    Greitzer, Frank L.; Dauenhauer, Peter M.; Wierks, Tamara G.; Podmore, Robin

    2009-04-01

    This report describes initial human factors evaluation of four visualization tools (Graphical Contingency Analysis, Force Directed Graphs, Phasor State Estimator and Mode Meter/ Mode Shapes) developed by PNNL, and proposed test plans that may be implemented to evaluate their utility in scenario-based experiments.

  20. Advanced Vibration Analysis Tool Developed for Robust Engine Rotor Designs

    NASA Technical Reports Server (NTRS)

    Min, James B.

    2005-01-01

    The primary objective of this research program is to develop vibration analysis tools, design tools, and design strategies to significantly improve the safety and robustness of turbine engine rotors. Bladed disks in turbine engines always feature small, random blade-to-blade differences, or mistuning. Mistuning can lead to a dramatic increase in blade forced-response amplitudes and stresses. Ultimately, this results in high-cycle fatigue, which is a major safety and cost concern. In this research program, the necessary steps will be taken to transform a state-of-the-art vibration analysis tool, the Turbo- Reduce forced-response prediction code, into an effective design tool by enhancing and extending the underlying modeling and analysis methods. Furthermore, novel techniques will be developed to assess the safety of a given design. In particular, a procedure will be established for using natural-frequency curve veerings to identify ranges of operating conditions (rotational speeds and engine orders) in which there is a great risk that the rotor blades will suffer high stresses. This work also will aid statistical studies of the forced response by reducing the necessary number of simulations. Finally, new strategies for improving the design of rotors will be pursued.

  1. Construction of an advanced software tool for planetary atmospheric modeling

    NASA Technical Reports Server (NTRS)

    Friedland, Peter; Keller, Richard M.; Mckay, Christopher P.; Sims, Michael H.; Thompson, David E.

    1992-01-01

    Scientific model-building can be a time intensive and painstaking process, often involving the development of large complex computer programs. Despite the effort involved, scientific models cannot be distributed easily and shared with other scientists. In general, implemented scientific models are complicated, idiosyncratic, and difficult for anyone but the original scientist/programmer to understand. We propose to construct a scientific modeling software tool that serves as an aid to the scientist in developing, using and sharing models. The proposed tool will include an interactive intelligent graphical interface and a high-level domain-specific modeling language. As a test bed for this research, we propose to develop a software prototype in the domain of planetary atmospheric modeling.

  2. Construction of an advanced software tool for planetary atmospheric modeling

    NASA Technical Reports Server (NTRS)

    Friedland, Peter; Keller, Richard M.; Mckay, Christopher P.; Sims, Michael H.; Thompson, David E.

    1993-01-01

    Scientific model-building can be a time intensive and painstaking process, often involving the development of large complex computer programs. Despite the effort involved, scientific models cannot be distributed easily and shared with other scientists. In general, implemented scientific models are complicated, idiosyncratic, and difficult for anyone but the original scientist/programmer to understand. We propose to construct a scientific modeling software tool that serves as an aid to the scientist in developing, using and sharing models. The proposed tool will include an interactive intelligent graphical interface and a high-level domain-specific modeling language. As a testbed for this research, we propose to develop a software prototype in the domain of planetary atmospheric modeling.

  3. Advanced tools and framework for historical film restoration

    NASA Astrophysics Data System (ADS)

    Croci, Simone; Aydın, Tunç Ozan; Stefanoski, Nikolce; Gross, Markus; Smolic, Aljosa

    2017-01-01

    Digital restoration of film content that has historical value is crucial for the preservation of cultural heritage. Also, digital restoration is not only a relevant application area of various video processing technologies that have been developed in computer graphics literature but also involves a multitude of unresolved research challenges. Currently, the digital restoration workflow is highly labor intensive and often heavily relies on expert knowledge. We revisit some key steps of this workflow and propose semiautomatic methods for performing them. To do that we build upon state-of-the-art video processing techniques by adding the components necessary for enabling (i) restoration of chemically degraded colors of the film stock, (ii) removal of excessive film grain through spatiotemporal filtering, and (iii) contrast recovery by transferring contrast from the negative film stock to the positive. We show that when applied individually our tools produce compelling results and when applied in concert significantly improve the degraded input content. Building on a conceptual framework of film restoration ensures the best possible combination of tools and use of available materials.

  4. The Bridging Advanced Developments for Exceptional Rehabilitation (BADER) Consortium: Reaching in Partnership for Optimal Orthopaedic Rehabilitation Outcomes.

    PubMed

    Stanhope, Steven J; Wilken, Jason M; Pruziner, Alison L; Dearth, Christopher L; Wyatt, Marilynn; Ziemke, Gregg W; Strickland, Rachel; Milbourne, Suzanne A; Kaufman, Kenton R

    2016-11-01

    The Bridging Advanced Developments for Exceptional Rehabilitation (BADER) Consortium began in September 2011 as a cooperative agreement with the Department of Defense (DoD) Congressionally Directed Medical Research Programs Peer Reviewed Orthopaedic Research Program. A partnership was formed with DoD Military Treatment Facilities (MTFs), U.S. Department of Veterans Affairs (VA) Centers, the National Institutes of Health (NIH), academia, and industry to rapidly conduct innovative, high-impact, and sustainable clinically relevant research. The BADER Consortium has a unique research capacity-building focus that creates infrastructures and strategically connects and supports research teams to conduct multiteam research initiatives primarily led by MTF and VA investigators.BADER relies on strong partnerships with these agencies to strengthen and support orthopaedic rehabilitation research. Its focus is on the rapid forming and execution of projects focused on obtaining optimal functional outcomes for patients with limb loss and limb injuries. The Consortium is based on an NIH research capacity-building model that comprises essential research support components that are anchored by a set of BADER-funded and initiative-launching studies. Through a partnership with the DoD/VA Extremity Trauma and Amputation Center of Excellence, the BADER Consortium's research initiative-launching program has directly supported the identification and establishment of eight BADER-funded clinical studies. BADER's Clinical Research Core (CRC) staff, who are embedded within each of the MTFs, have supported an additional 37 non-BADER Consortium-funded projects. Additional key research support infrastructures that expedite the process for conducting multisite clinical trials include an omnibus Cooperative Research and Development Agreement and the NIH Clinical Trials Database. A 2015 Defense Health Board report highlighted the Consortium's vital role, stating the research capabilities of the Do

  5. Advanced Epi Tools for Gallium Nitride Light Emitting Diode Devices

    SciTech Connect

    Patibandla, Nag; Agrawal, Vivek

    2012-12-01

    Over the course of this program, Applied Materials, Inc., with generous support from the United States Department of Energy, developed a world-class three chamber III-Nitride epi cluster tool for low-cost, high volume GaN growth for the solid state lighting industry. One of the major achievements of the program was to design, build, and demonstrate the world’s largest wafer capacity HVPE chamber suitable for repeatable high volume III-Nitride template and device manufacturing. Applied Materials’ experience in developing deposition chambers for the silicon chip industry over many decades resulted in many orders of magnitude reductions in the price of transistors. That experience and understanding was used in developing this GaN epi deposition tool. The multi-chamber approach, which continues to be unique in the ability of the each chamber to deposit a section of the full device structure, unlike other cluster tools, allows for extreme flexibility in the manufacturing process. This robust architecture is suitable for not just the LED industry, but GaN power devices as well, both horizontal and vertical designs. The new HVPE technology developed allows GaN to be grown at a rate unheard of with MOCVD, up to 20x the typical MOCVD rates of 3{micro}m per hour, with bulk crystal quality better than the highest-quality commercial GaN films grown by MOCVD at a much cheaper overall cost. This is a unique development as the HVPE process has been known for decades, but never successfully commercially developed for high volume manufacturing. This research shows the potential of the first commercial-grade HVPE chamber, an elusive goal for III-V researchers and those wanting to capitalize on the promise of HVPE. Additionally, in the course of this program, Applied Materials built two MOCVD chambers, in addition to the HVPE chamber, and a robot that moves wafers between them. The MOCVD chambers demonstrated industry-leading wavelength yield for GaN based LED wafers and industry

  6. AN ADVANCED TOOL FOR APPLIED INTEGRATED SAFETY MANAGEMENT

    SciTech Connect

    Potts, T. Todd; Hylko, James M.; Douglas, Terence A.

    2003-02-27

    WESKEM, LLC's Environmental, Safety and Health (ES&H) Department had previously assessed that a lack of consistency, poor communication and using antiquated communication tools could result in varying operating practices, as well as a failure to capture and disseminate appropriate Integrated Safety Management (ISM) information. To address these issues, the ES&H Department established an Activity Hazard Review (AHR)/Activity Hazard Analysis (AHA) process for systematically identifying, assessing, and controlling hazards associated with project work activities during work planning and execution. Depending on the scope of a project, information from field walkdowns and table-top meetings are collected on an AHR form. The AHA then documents the potential failure and consequence scenarios for a particular hazard. Also, the AHA recommends whether the type of mitigation appears appropriate or whether additional controls should be implemented. Since the application is web based, the information is captured into a single system and organized according to the >200 work activities already recorded in the database. Using the streamlined AHA method improved cycle time from over four hours to an average of one hour, allowing more time to analyze unique hazards and develop appropriate controls. Also, the enhanced configuration control created a readily available AHA library to research and utilize along with standardizing hazard analysis and control selection across four separate work sites located in Kentucky and Tennessee. The AHR/AHA system provides an applied example of how the ISM concept evolved into a standardized field-deployed tool yielding considerable efficiency gains in project planning and resource utilization. Employee safety is preserved through detailed planning that now requires only a portion of the time previously necessary. The available resources can then be applied to implementing appropriate engineering, administrative and personal protective equipment

  7. Whyever bladder tissue engineering clinical applications still remain unusual even though many intriguing technological advances have been reached?

    PubMed Central

    ALBERTI, C.

    2016-01-01

    To prevent problematic outcomes of bowel-based bladder reconstructive surgery, such as prosthetic tumors and systemic metabolic complications, research works, to either regenerate and strengthen failing organ or build organ replacement biosubstitute, have been turned, from 90s of the last century, to both regenerative medicine and tissue engineering. Various types of acellular matrices, naturally-derived materials, synthetic polymers have been used for either “unseeded” (cell free) or autologous “cell seeded” tissue engineering scaffolds. Different categories of cell sources – from autologous differentiated urothelial and smooth muscle cells to natural or laboratory procedure-derived stem cells – have been taken into consideration to reach the construction of suitable “cell seeded” templates. Current clinically validated bladder tissue engineering approaches essentially consist of augmentation cystoplasty in patients suffering from poorly compliant neuropathic bladder. No clinical applications of wholly tissue engineered neobladder have been carried out to radical-reconstructive surgical treatment of bladder malignancies or chronic inflammation-due vesical coarctation. Reliable reasons why bladder tissue engineering clinical applications so far remain unusual, particularly imply the risk of graft ischemia, hence its both fibrous contraction and even worse perforation. Therefore, the achievement of graft vascular network (vasculogenesis) could allow, together with the promotion of host surrounding vessel sprouting (angiogenesis), an effective graft blood supply, so avoiding the ischemia-related serious complications. PMID:27142819

  8. Advanced Flow Control as a Management Tool in the National Airspace System

    NASA Technical Reports Server (NTRS)

    Wugalter, S.

    1974-01-01

    Advanced Flow Control is closely related to Air Traffic Control. Air Traffic Control is the business of the Federal Aviation Administration. To formulate an understanding of advanced flow control and its use as a management tool in the National Airspace System, it becomes necessary to speak somewhat of air traffic control, the role of FAA, and their relationship to advanced flow control. Also, this should dispell forever, any notion that advanced flow control is the inspirational master valve scheme to be used on the Alaskan Oil Pipeline.

  9. Advanced tools for astronomical time series and image analysis

    NASA Astrophysics Data System (ADS)

    Scargle, Jeffrey D.

    The algorithms described here, which I have developed for applications in X-ray and γ-ray astronomy, will hopefully be of use in other ways, perhaps aiding in the exploration of modern astronomy's data cornucopia. The goal is to describe principled approaches to some ubiquitous problems, such as detection and characterization of periodic and aperiodic signals, estimation of time delays between multiple time series, and source detection in noisy images with noisy backgrounds. The latter problem is related to detection of clusters in data spaces of various dimensions. A goal of this work is to achieve a unifying view of several related topics: signal detection and characterization, cluster identification, classification, density estimation, and multivariate regression. In addition to being useful for analysis of data from space-based and ground-based missions, these algorithms may be a basis for a future automatic science discovery facility, and in turn provide analysis tools for the Virtual Observatory. This chapter has ties to those by Larry Bretthorst, Tom Loredo, Alanna Connors, Fionn Murtagh, Jim Berger, David van Dyk, Vicent Martinez & Enn Saar.

  10. Atomic force microscopy as an advanced tool in neuroscience

    PubMed Central

    Jembrek, Maja Jazvinšćak; Šimić, Goran; Hof, Patrick R.; Šegota, Suzana

    2015-01-01

    This review highlights relevant issues about applications and improvements of atomic force microscopy (AFM) toward a better understanding of neurodegenerative changes at the molecular level with the hope of contributing to the development of effective therapeutic strategies for neurodegenerative illnesses. The basic principles of AFM are briefly discussed in terms of evaluation of experimental data, including the newest PeakForce Quantitative Nanomechanical Mapping (QNM) and the evaluation of Young’s modulus as the crucial elasticity parameter. AFM topography, revealed in imaging mode, can be used to monitor changes in live neurons over time, representing a valuable tool for high-resolution detection and monitoring of neuronal morphology. The mechanical properties of living cells can be quantified by force spectroscopy as well as by new AFM. A variety of applications are described, and their relevance for specific research areas discussed. In addition, imaging as well as non-imaging modes can provide specific information, not only about the structural and mechanical properties of neuronal membranes, but also on the cytoplasm, cell nucleus, and particularly cytoskeletal components. Moreover, new AFM is able to provide detailed insight into physical structure and biochemical interactions in both physiological and pathophysiological conditions. PMID:28123795

  11. First tier modeling of consumer dermal exposure to substances in consumer articles under REACH: a quantitative evaluation of the ECETOC TRA for consumers tool.

    PubMed

    Delmaar, J E; Bokkers, B G H; ter Burg, W; van Engelen, J G M

    2013-02-01

    The demonstration of safe use of chemicals in consumer products, as required under REACH, is proposed to follow a tiered process. In the first tier, simple conservative methods and assumptions should be made to quickly verify whether risks for a particular use are expected. The ECETOC TRA Consumer Exposure Tool was developed to assist in first tier risk assessments for substances in consumer products. The ECETOC TRA is not a prioritization tool, but is meant as a first screening. Therefore, the exposure assessment needs to cover all products/articles in a specific category. For the assessment of the dermal exposure for substances in articles, ECETOC TRA uses the concept of a 'contact layer', a hypothetical layer that limits the exposure to a substance contained in the product. For each product/article category, ECETOC TRA proposes default values for the thickness of this contact layer. As relevant experimental exposure data is currently lacking, default values are based on expert judgment alone. In this paper it is verified whether this concept meets the requirement of being a conservative exposure evaluation method. This is done by confronting the ECETOC TRA expert judgment based predictions with a mechanistic emission model, based on the well established theory of diffusion of substances in materials. Diffusion models have been applied and tested in many applications of emission modeling. Experimentally determined input data for a number of material and substance combinations are available. The estimated emissions provide information on the range of emissions that could occur in reality. First tier tools such as ECETOC TRA tool are required to cover all products/articles in a category and to provide estimates that are at least as high as is expected on the basis of current scientific knowledge. Since this was not the case, it is concluded that the ECETOC TRA does not provide a proper conservative estimation method for the dermal exposure to articles. An

  12. Electrochemical Processing Tools for Advanced Copper Interconnects: An Introduction

    NASA Astrophysics Data System (ADS)

    Datta, Madhav

    The change from vacuum-deposited aluminum to electroplated copper in 1997 brought about a paradigm shift in interconnect technology and in chip making [1]. Since then, most of the leading chip manufacturers have converted to electroplated Cu technology for chip interconnects. Cu interconnects are fabricated by dual Damascene process which is referred to a metallization patterning process by which two insulator (dielectric) levels are patterned, filled with copper, and planarized to create a metal layer consisting of vias and lines. The process steps consist of laying a sandwich of two levels of insulator and etch stop layers that are patterned as holes for vias and troughs for lines. They are then filled with a single metallization step. Finally, the excess material is removed, and the wafer is planarized by chemical mechanical polishing (CMP). While finer details of exact sequence of fabrication steps vary, the end result of forming a metal layer remains the same in which vias are formed in the lower layer, and trenches are formed in the upper layer. Electroplating enables deposition of Cu in via holes and overlying trenches in a single step thus eliminating a via/line interface and significantly reducing the cycle time. Due to these reasons and due to relatively less expensive tooling, electroplating is a cost-effective and efficient process for Cu interconnects [2, 3]. Compared with vacuum deposition processes, electroplated Cu provides improved super filling capabilities and abnormal grain growth phenomena. These properties contribute significantly to improved reliability of Cu interconnects. With the proper choice of additives and plating conditions, void-free, seam-free Damascene deposits are obtained which eliminates surface-like fast diffusion paths for Cu electromigration.

  13. Advancing alternate tools: why science education needs CRP and CRT

    NASA Astrophysics Data System (ADS)

    Dodo Seriki, Vanessa

    2016-09-01

    Ridgeway and Yerrick's paper, Whose banner are we waving?: exploring STEM partnerships for marginalized urban youth, unearthed the tensions that existed between a local community "expert" and a group of students and their facilitator in an afterschool program. Those of us who work with youth who are traditionally marginalized, understand the importance of teaching in culturally relevant ways, but far too often—as Ridgeway and Yerrick shared—community partners have beliefs, motives, and ideologies that are incompatible to the program's mission and goals. Nevertheless, we often enter partnerships assuming that the other party understands the needs of the students or community; understands how in U.S. society White is normative while all others are deficient; and understands how to engage with students in culturally relevant ways. This forum addresses the underlying assumption, described in the Ridgeway and Yerrick article, that educators—despite their background and experiences—are able to teach in culturally relevant ways. Additionally, I assert based on the finding in the article that just as Ladson-Billings and Tate (Teach Coll Rec 97(1):47-68, 1995) asserted, race in the U.S. society, as a scholarly pursuit, was under theorized. The same is true of science education; race in science education is under theorized and the use of culturally relevant pedagogy and critical race theory as a pedagogical model and analytical tool, respectively, in science education is minimal. The increased use of both would impact our understanding of who does science, and how to broaden participation among people of color.

  14. Teaching Advanced Data Analysis Tools to High School Astronomy Students

    NASA Astrophysics Data System (ADS)

    Black, David V.; Herring, Julie; Hintz, Eric G.

    2015-01-01

    A major barrier to becoming an astronomer is learning how to analyze astronomical data, such as using photometry to compare the brightness of stars. Most fledgling astronomers learn observation, data reduction, and analysis skills through an upper division college class. If the same skills could be taught in an introductory high school astronomy class, then more students would have an opportunity to do authentic science earlier, with implications for how many choose to become astronomers. Several software tools have been developed that can analyze astronomical data ranging from fairly straightforward (AstroImageJ and DS9) to very complex (IRAF and DAOphot). During the summer of 2014, a study was undertaken at Brigham Young University through a Research Experience for Teachers (RET) program to evaluate the effectiveness and ease-of-use of these four software packages. Standard tasks tested included creating a false-color IR image using WISE data in DS9, Adobe Photoshop, and The Gimp; a multi-aperture analyses of variable stars over time using AstroImageJ; creating Spectral Energy Distributions (SEDs) of stars using photometry at multiple wavelengths in AstroImageJ and DS9; and color-magnitude and hydrogen alpha index diagrams for open star clusters using IRAF and DAOphot. Tutorials were then written and combined with screen captures to teach high school astronomy students at Walden School of Liberal Arts in Provo, UT how to perform these same tasks. They analyzed image data using the four software packages, imported it into Microsoft Excel, and created charts using images from BYU's 36-inch telescope at their West Mountain Observatory. The students' attempts to complete these tasks were observed, mentoring was provided, and the students then reported on their experience through a self-reflection essay and concept test. Results indicate that high school astronomy students can successfully complete professional-level astronomy data analyses when given detailed

  15. Advances in Coupling of Kinetics and Molecular Scale Tools to Shed Light on Soil Biogeochemical Processes

    SciTech Connect

    Sparks, Donald

    2014-09-02

    Biogeochemical processes in soils such as sorption, precipitation, and redox play critical roles in the cycling and fate of nutrients, metal(loid)s and organic chemicals in soil and water environments. Advanced analytical tools enable soil scientists to track these processes in real-time and at the molecular scale. Our review focuses on recent research that has employed state-of-the-art molecular scale spectroscopy, coupled with kinetics, to elucidate the mechanisms of nutrient and metal(loid) reactivity and speciation in soils. We found that by coupling kinetics with advanced molecular and nano-scale tools major advances have been made in elucidating important soil chemical processes including sorption, precipitation, dissolution, and redox of metal(loids) and nutrients. Such advances will aid in better predicting the fate and mobility of nutrients and contaminants in soils and water and enhance environmental and agricultural sustainability.

  16. REACH Presentation.

    ERIC Educational Resources Information Center

    Bucklee, Joanne

    In an effort to provide support for employees and their families, Red Deer College (RDC) developed the Resources, Employees, Assistance, Counselling, and Health (REACH) program. The program is administered by a committee of five people who represent the five major employee groups at the college (i.e., senior administration, middle administration,…

  17. Utility of the advanced chronic kidney disease patient management tools: case studies.

    PubMed

    Patwardhan, Meenal B; Matchar, David B; Samsa, Gregory P; Haley, William E

    2008-01-01

    Appropriate management of advanced chronic kidney disease (CKD) delays or limits its progression. The Advanced CKD Patient Management Toolkit was developed using a process-improvement technique to assist patient management and address CKD-specific management issues. We pilot tested the toolkit in 2 community nephrology practices, assessed the utility of individual tools, and evaluated the impact on conformance to an advanced CKD guideline through patient chart abstraction. Tool use was distinct in the 2 sites and depended on the site champion's involvement, the extent of process reconfiguration demanded by a tool, and its perceived value. Baseline conformance varied across guideline recommendations (averaged 54%). Posttrial conformance increased in all clinical areas (averaged 59%). Valuable features of the toolkit in real-world settings were its ability to: facilitate tool selection, direct implementation efforts in response to a baseline performance audit, and allow selection of tool versions and customizing them. Our results suggest that systematically created, multifaceted, and customizable tools can promote guideline conformance.

  18. Triadic (ecological, neural, cognitive) niche construction: a scenario of human brain evolution extrapolating tool use and language from the control of reaching actions.

    PubMed

    Iriki, Atsushi; Taoka, Miki

    2012-01-12

    Hominin evolution has involved a continuous process of addition of new kinds of cognitive capacity, including those relating to manufacture and use of tools and to the establishment of linguistic faculties. The dramatic expansion of the brain that accompanied additions of new functional areas would have supported such continuous evolution. Extended brain functions would have driven rapid and drastic changes in the hominin ecological niche, which in turn demanded further brain resources to adapt to it. In this way, humans have constructed a novel niche in each of the ecological, cognitive and neural domains, whose interactions accelerated their individual evolution through a process of triadic niche construction. Human higher cognitive activity can therefore be viewed holistically as one component in a terrestrial ecosystem. The brain's functional characteristics seem to play a key role in this triadic interaction. We advance a speculative argument about the origins of its neurobiological mechanisms, as an extension (with wider scope) of the evolutionary principles of adaptive function in the animal nervous system. The brain mechanisms that subserve tool use may bridge the gap between gesture and language--the site of such integration seems to be the parietal and extending opercular cortices.

  19. Second NASA Technical Interchange Meeting (TIM): Advanced Technology Lifecycle Analysis System (ATLAS) Technology Tool Box (TTB)

    NASA Technical Reports Server (NTRS)

    ONeil, D. A.; Mankins, J. C.; Christensen, C. B.; Gresham, E. C.

    2005-01-01

    The Advanced Technology Lifecycle Analysis System (ATLAS), a spreadsheet analysis tool suite, applies parametric equations for sizing and lifecycle cost estimation. Performance, operation, and programmatic data used by the equations come from a Technology Tool Box (TTB) database. In this second TTB Technical Interchange Meeting (TIM), technologists, system model developers, and architecture analysts discussed methods for modeling technology decisions in spreadsheet models, identified specific technology parameters, and defined detailed development requirements. This Conference Publication captures the consensus of the discussions and provides narrative explanations of the tool suite, the database, and applications of ATLAS within NASA s changing environment.

  20. Data preparation solution for e-beam multiple pass exposure: reaching sub-22nm nodes with a tool dedicated to 45 nm

    NASA Astrophysics Data System (ADS)

    Martin, Luc; Manakli, Serdar; Bayle, Sébastien; Choi, Kang-Hoon; Gutsch, Manuela; Pradelles, Jonathan; Bustos, Jessy

    2011-04-01

    Electron Beam Direct Write (EBDW) lithography is used in the IC manufacturing industry to sustain optical lithography for prototyping applications and low volume manufacturing. It is also used in R&D to develop advanced technologies, ahead of mass production. As microelectronics is now moving towards the 32nm node and beyond, the specifications in terms of dimension control and roughness becomes tighter. In addition, the shrink of the size and pitch of features significantly reduces the process window of lithographic tools. In EBDW, the standard proximity effects corrections only based on dose modulation show difficulties to provide the required Energy Latitude for patterning structures designed below 45nm. A new approach is thus needed to improve the process window of EBDW lithography and push its resolution capabilities. In previous papers, a new writing strategy based on multiple pass exposure has been introduced and optimized to pattern critical dense lines. This new technique consists in adding small electron Resolution Improvement Features (eRIFs) on top of the nominal structures. Then this new design is exposed in two successive passes with optimized doses. Previous studies were led to evaluate this new writing technique and establish rules to optimize the design of the eRIF. Significant improvements have already been demonstrated on SRAM and Logic structures down to the 16nm node. These results were obtained with a tool dedicated to the 45nm node. The next step of this work is thus to automatically implement the eRIF to correct large-scale layouts. In this paper, a new data preparation flow is set up for EBDW lithography. It uses the eRIF solution as a full advanced correction method for critical structures. The specific correction rules established in our previous studies are implemented to improve the CD control and the patterning of corners and line ends. Moreover, the dose and shape of the eRIFs are automatically tuned to best fit the nominal design

  1. Earthquake information products and tools from the Advanced National Seismic System (ANSS)

    USGS Publications Warehouse

    Wald, Lisa

    2006-01-01

    This Fact Sheet provides a brief description of postearthquake tools and products provided by the Advanced National Seismic System (ANSS) through the U.S. Geological Survey Earthquake Hazards Program. The focus is on products specifically aimed at providing situational awareness in the period immediately following significant earthquake events.

  2. Spontaneous tool-use: an observation of a dingo (Canis dingo) using a table to access an out-of-reach food reward.

    PubMed

    Smith, Bradley Philip; Appleby, Robert George; Litchfield, Carla Anita

    2012-03-01

    Opportunities to observe non-human animals exhibiting naturalistic 'high-order' behaviour are rare. Examples featuring canids, although often anecdotal and involving captive animals are potentially valuable, as they may provide an opportunity to examine complex problem-solving behaviour not easily observed in free-ranging settings. This paper describes observations of two captive male dingoes (Canis dingo), representing possible examples of high-order behaviour. The first set of observations involved a sub-adult male that spontaneously (i.e., without training) learned to move objects around his enclosure, apparently to multiple ends, such as in an effort to gain the additional height required to attain objects otherwise out of reach, or to attain a better view of his surroundings. The second set of observations involved an adult male that learned to open a gate, possibly in an effort to gain access to a female. These observations add to the small number of anecdotal accounts offering a window into the cognitive abilities of canids, and the observations involving the sub-adult male appear to be the first documented cases of tool-use in a canid.

  3. Synthetic biology and molecular genetics in non-conventional yeasts: Current tools and future advances.

    PubMed

    Wagner, James M; Alper, Hal S

    2016-04-01

    Coupling the tools of synthetic biology with traditional molecular genetic techniques can enable the rapid prototyping and optimization of yeast strains. While the era of yeast synthetic biology began in the well-characterized model organism Saccharomyces cerevisiae, it is swiftly expanding to include non-conventional yeast production systems such as Hansenula polymorpha, Kluyveromyces lactis, Pichia pastoris, and Yarrowia lipolytica. These yeasts already have roles in the manufacture of vaccines, therapeutic proteins, food additives, and biorenewable chemicals, but recent synthetic biology advances have the potential to greatly expand and diversify their impact on biotechnology. In this review, we summarize the development of synthetic biological tools (including promoters and terminators) and enabling molecular genetics approaches that have been applied in these four promising alternative biomanufacturing platforms. An emphasis is placed on synthetic parts and genome editing tools. Finally, we discuss examples of synthetic tools developed in other organisms that can be adapted or optimized for these hosts in the near future.

  4. Measuring political commitment and opportunities to advance food and nutrition security: piloting a rapid assessment tool.

    PubMed

    Fox, Ashley M; Balarajan, Yarlini; Cheng, Chloe; Reich, Michael R

    2015-06-01

    Lack of political commitment has been identified as a primary reason for the low priority that food and nutrition interventions receive from national governments relative to the high disease burden caused by malnutrition. Researchers have identified a number of factors that contribute to food and nutrition's 'low-priority cycle' on national policy agendas, but few tools exist to rapidly measure political commitment and identify opportunities to advance food and nutrition on the policy agenda. This article presents a theory-based rapid assessment approach to gauging countries' level of political commitment to food and nutrition security and identifying opportunities to advance food and nutrition on the policy agenda. The rapid assessment tool was piloted among food and nutrition policymakers and planners in 10 low- and middle-income countries in April to June 2013. Food and nutrition commitment and policy opportunity scores were calculated for each country and strategies to advance food and nutrition on policy agendas were designed for each country. The article finds that, in a majority of countries, political leaders had verbally and symbolically committed to addressing food and nutrition, but adequate financial resources were not allocated to implement specific programmes. In addition, whereas the low cohesion of the policy community has been viewed a major underlying cause of the low-priority status of food and nutrition, the analysis finds that policy community cohesion and having a well thought-out policy alternative were present in most countries. This tool may be useful to policymakers and planners providing information that can be used to benchmark and/or evaluate advocacy efforts to advance reforms in the food and nutrition sector; furthermore, the results can help identify specific strategies that can be employed to move the food and nutrition agenda forward. This tool complements others that have been recently developed to measure national commitment to

  5. "Brown's" Far Reaching Impact

    ERIC Educational Resources Information Center

    Chinn, Philip C.

    2004-01-01

    Although the 1954 "Brown v. Board of Education" U.S. Supreme Court decision changed the face of American education forever, few individuals at that time could have fully realized its far-reaching implications. Certainly, the National Association for the Advancement of Colored People Legal Director Thurgood Marshall in his arguments was…

  6. Advanced Risk Reduction Tool (ARRT) Special Case Study Report: Science and Engineering Technical Assessments (SETA) Program

    NASA Technical Reports Server (NTRS)

    Kirsch, Paul J.; Hayes, Jane; Zelinski, Lillian

    2000-01-01

    This special case study report presents the Science and Engineering Technical Assessments (SETA) team's findings for exploring the correlation between the underlying models of Advanced Risk Reduction Tool (ARRT) relative to how it identifies, estimates, and integrates Independent Verification & Validation (IV&V) activities. The special case study was conducted under the provisions of SETA Contract Task Order (CTO) 15 and the approved technical approach documented in the CTO-15 Modification #1 Task Project Plan.

  7. Reaching Out

    NASA Astrophysics Data System (ADS)

    Moore, John W.

    1999-11-01

    In the United States, National Chemistry Week is November 7-13. (For more NCW information, go to http://www.acs.org/ncw/.) NCW's theme, celebrating polymers, is echoed in this issue (pages 1497-1501, 1512-1513, 1521-1540). Almost certainly there will be chemists in your area spending a great deal of their time on outreach activities for children and the general public during NCW. Chances are good that many Journal readers like you will be among them. And there are probably many more outreach programs that you or your acquaintances lead during the rest of the year. This month of NCW seems an appropriate time to reflect on the tremendous benefits that outreach programs provide. Early examples of outreach involved books, public lectures, and chemical demonstrations. In 1800 Count Rumford collaborated with influential Londoners to establish the Royal Institution as a means of providing lectures on science and technology to help working people to improve their lot. Humphry Davy, Michael Faraday, and many others continued the tradition. Faraday's own interest in science was sparked in part by Jane Marcet's book Conversations in Chemistry, whose friendly style made its contents accessible and fascinating to the young, highly intelligent bookbinder's apprentice. In the United States, Benjamin Silliman, first professor of chemistry at Yale, became widely known for his textbooks on geology and chemistry and for his ability as a popular lecturer. Silliman's lecture tours took him as far from New Haven as St. Louis and New Orleans. By the mid-1800s societies for the advancement of science and of chemistry were being set up in Europe. In 1876 American chemists who gathered at Priestley's grave in Northumberland, Pennsylvania, to commemorate the centennial of the discovery of oxygen saw the need for a permanent organization and founded the American Chemical Society. By the beginning of the 20th century these societies were supporting education and public awareness of science

  8. Advanced gradient-index lens design tools to maximize system performance and reduce SWaP

    NASA Astrophysics Data System (ADS)

    Campbell, Sawyer D.; Nagar, Jogender; Brocker, Donovan E.; Easum, John A.; Turpin, Jeremiah P.; Werner, Douglas H.

    2016-05-01

    GRadient-INdex (GRIN) lenses have long been of interest due to their potential for providing levels of performance unachievable with traditional homogeneous lenses. While historically limited by a lack of suitable materials, rapid advancements in manufacturing techniques, including 3D printing, have recently kindled a renewed interest in GRIN optics. Further increasing the desire for GRIN devices has been the advent of Transformation Optics (TO), which provides the mathematical framework for representing the behavior of electromagnetic radiation in a given geometry by "transforming" it to an alternative, usually more desirable, geometry through an appropriate mapping of the constituent material parameters. Using TO, aspherical lenses can be transformed to simpler spherical and flat geometries or even rotationally-asymmetric shapes which result in true 3D GRIN profiles. Meanwhile, there is a critical lack of suitable design tools which can effectively evaluate the optical wave propagation through 3D GRIN profiles produced by TO. Current modeling software packages for optical lens systems also lack advanced multi-objective global optimization capability which allows the user to explicitly view the trade-offs between all design objectives such as focus quality, FOV, ▵nand focal drift due to chromatic aberrations. When coupled with advanced design methodologies such as TO, wavefront matching (WFM), and analytical achromatic GRIN theory, these tools provide a powerful framework for maximizing SWaP (Size, Weight and Power) reduction in GRIN-enabled optical systems. We provide an overview of our advanced GRIN design tools and examples which minimize the presence of mono- and polychromatic aberrations in the context of reducing SWaP.

  9. Cellulosome-based, Clostridium-derived multi-functional enzyme complexes for advanced biotechnology tool development: advances and applications.

    PubMed

    Hyeon, Jeong Eun; Jeon, Sang Duck; Han, Sung Ok

    2013-11-01

    The cellulosome is one of nature's most elegant and elaborate nanomachines and a key biological and biotechnological macromolecule that can be used as a multi-functional protein complex tool. Each protein module in the cellulosome system is potentially useful in an advanced biotechnology application. The high-affinity interactions between the cohesin and dockerin domains can be used in protein-based biosensors to improve both sensitivity and selectivity. The scaffolding protein includes a carbohydrate-binding module (CBM) that attaches strongly to cellulose substrates and facilitates the purification of proteins fused with the dockerin module through a one-step CBM purification method. Although the surface layer homology (SLH) domain of CbpA is not present in other strains, replacement of the cell surface anchoring domain allows a foreign protein to be displayed on the surface of other strains. The development of a hydrolysis enzyme complex is a useful strategy for consolidated bioprocessing (CBP), enabling microorganisms with biomass hydrolysis activity. Thus, the development of various configurations of multi-functional protein complexes for use as tools in whole-cell biocatalyst systems has drawn considerable attention as an attractive strategy for bioprocess applications. This review provides a detailed summary of the current achievements in Clostridium-derived multi-functional complex development and the impact of these complexes in various areas of biotechnology.

  10. Anvil Forecast Tool in the Advanced Weather Interactive Processing System (AWIPS)

    NASA Technical Reports Server (NTRS)

    Barrett, Joe H., III; Hood, Doris

    2009-01-01

    Launch Weather Officers (LWOs) from the 45th Weather Squadron (45 WS) and forecasters from the National Weather Service (NWS) Spaceflight Meteorology Group (SMG) have identified anvil forecasting as one of their most challenging tasks when predicting the probability of violating the Lightning Launch Commit Criteria (LLCC) (Krider et al. 2006; Space Shuttle Flight Rules (FR), NASA/JSC 2004)). As a result, the Applied Meteorology Unit (AMU) developed a tool that creates an anvil threat corridor graphic that can be overlaid on satellite imagery using the Meteorological Interactive Data Display System (MIDDS, Short and Wheeler, 2002). The tool helps forecasters estimate the locations of thunderstorm anvils at one, two, and three hours into the future. It has been used extensively in launch and landing operations by both the 45 WS and SMG. The Advanced Weather Interactive Processing System (AWIPS) is now used along with MIDDS for weather analysis and display at SMG. In Phase I of this task, SMG tasked the AMU to transition the tool from MIDDS to AWIPS (Barrett et aI., 2007). For Phase II, SMG requested the AMU make the Anvil Forecast Tool in AWIPS more configurable by creating the capability to read model gridded data from user-defined model files instead of hard-coded files. An NWS local AWIPS application called AGRID was used to accomplish this. In addition, SMG needed to be able to define the pressure levels for the model data, instead of hard-coding the bottom level as 300 mb and the top level as 150 mb. This paper describes the initial development of the Anvil Forecast Tool for MIDDS, followed by the migration of the tool to AWIPS in Phase I. It then gives a detailed presentation of the Phase II improvements to the AWIPS tool.

  11. Recovery Act: Advanced Interaction, Computation, and Visualization Tools for Sustainable Building Design

    SciTech Connect

    Greenberg, Donald P.; Hencey, Brandon M.

    2013-08-20

    Current building energy simulation technology requires excessive labor, time and expertise to create building energy models, excessive computational time for accurate simulations and difficulties with the interpretation of the results. These deficiencies can be ameliorated using modern graphical user interfaces and algorithms which take advantage of modern computer architectures and display capabilities. To prove this hypothesis, we developed an experimental test bed for building energy simulation. This novel test bed environment offers an easy-to-use interactive graphical interface, provides access to innovative simulation modules that run at accelerated computational speeds, and presents new graphics visualization methods to interpret simulation results. Our system offers the promise of dramatic ease of use in comparison with currently available building energy simulation tools. Its modular structure makes it suitable for early stage building design, as a research platform for the investigation of new simulation methods, and as a tool for teaching concepts of sustainable design. Improvements in the accuracy and execution speed of many of the simulation modules are based on the modification of advanced computer graphics rendering algorithms. Significant performance improvements are demonstrated in several computationally expensive energy simulation modules. The incorporation of these modern graphical techniques should advance the state of the art in the domain of whole building energy analysis and building performance simulation, particularly at the conceptual design stage when decisions have the greatest impact. More importantly, these better simulation tools will enable the transition from prescriptive to performative energy codes, resulting in better, more efficient designs for our future built environment.

  12. Advanced computational tools for optimization and uncertainty quantification of carbon capture processes

    SciTech Connect

    Miller, David C.; Ng, Brenda; Eslick, John

    2014-01-01

    Advanced multi-scale modeling and simulation has the potential to dramatically reduce development time, resulting in considerable cost savings. The Carbon Capture Simulation Initiative (CCSI) is a partnership among national laboratories, industry and universities that is developing, demonstrating, and deploying a suite of multi-scale modeling and simulation tools. One significant computational tool is FOQUS, a Framework for Optimization and Quantification of Uncertainty and Sensitivity, which enables basic data submodels, including thermodynamics and kinetics, to be used within detailed process models to rapidly synthesize and optimize a process and determine the level of uncertainty associated with the resulting process. The overall approach of CCSI is described with a more detailed discussion of FOQUS and its application to carbon capture systems.

  13. Proposal for constructing an advanced software tool for planetary atmospheric modeling

    NASA Technical Reports Server (NTRS)

    Keller, Richard M.; Sims, Michael H.; Podolak, Esther; Mckay, Christopher P.; Thompson, David E.

    1990-01-01

    Scientific model building can be a time intensive and painstaking process, often involving the development of large and complex computer programs. Despite the effort involved, scientific models cannot easily be distributed and shared with other scientists. In general, implemented scientific models are complex, idiosyncratic, and difficult for anyone but the original scientist/programmer to understand. We believe that advanced software techniques can facilitate both the model building and model sharing process. We propose to construct a scientific modeling software tool that serves as an aid to the scientist in developing and using models. The proposed tool will include an interactive intelligent graphical interface and a high level, domain specific, modeling language. As a testbed for this research, we propose development of a software prototype in the domain of planetary atmospheric modeling.

  14. NASA Technical Interchange Meeting (TIM): Advanced Technology Lifecycle Analysis System (ATLAS) Technology Tool Box

    NASA Technical Reports Server (NTRS)

    ONeil, D. A.; Craig, D. A.; Christensen, C. B.; Gresham, E. C.

    2005-01-01

    The objective of this Technical Interchange Meeting was to increase the quantity and quality of technical, cost, and programmatic data used to model the impact of investing in different technologies. The focus of this meeting was the Technology Tool Box (TTB), a database of performance, operations, and programmatic parameters provided by technologists and used by systems engineers. The TTB is the data repository used by a system of models known as the Advanced Technology Lifecycle Analysis System (ATLAS). This report describes the result of the November meeting, and also provides background information on ATLAS and the TTB.

  15. Plant Aquaporins: Genome-Wide Identification, Transcriptomics, Proteomics, and Advanced Analytical Tools

    PubMed Central

    Deshmukh, Rupesh K.; Sonah, Humira; Bélanger, Richard R.

    2016-01-01

    Aquaporins (AQPs) are channel-forming integral membrane proteins that facilitate the movement of water and many other small molecules. Compared to animals, plants contain a much higher number of AQPs in their genome. Homology-based identification of AQPs in sequenced species is feasible because of the high level of conservation of protein sequences across plant species. Genome-wide characterization of AQPs has highlighted several important aspects such as distribution, genetic organization, evolution and conserved features governing solute specificity. From a functional point of view, the understanding of AQP transport system has expanded rapidly with the help of transcriptomics and proteomics data. The efficient analysis of enormous amounts of data generated through omic scale studies has been facilitated through computational advancements. Prediction of protein tertiary structures, pore architecture, cavities, phosphorylation sites, heterodimerization, and co-expression networks has become more sophisticated and accurate with increasing computational tools and pipelines. However, the effectiveness of computational approaches is based on the understanding of physiological and biochemical properties, transport kinetics, solute specificity, molecular interactions, sequence variations, phylogeny and evolution of aquaporins. For this purpose, tools like Xenopus oocyte assays, yeast expression systems, artificial proteoliposomes, and lipid membranes have been efficiently exploited to study the many facets that influence solute transport by AQPs. In the present review, we discuss genome-wide identification of AQPs in plants in relation with recent advancements in analytical tools, and their availability and technological challenges as they apply to AQPs. An exhaustive review of omics resources available for AQP research is also provided in order to optimize their efficient utilization. Finally, a detailed catalog of computational tools and analytical pipelines is

  16. Global search tool for the Advanced Photon Source Integrated Relational Model of Installed Systems (IRMIS) database.

    SciTech Connect

    Quock, D. E. R.; Cianciarulo, M. B.; APS Engineering Support Division; Purdue Univ.

    2007-01-01

    The Integrated Relational Model of Installed Systems (IRMIS) is a relational database tool that has been implemented at the Advanced Photon Source to maintain an updated account of approximately 600 control system software applications, 400,000 process variables, and 30,000 control system hardware components. To effectively display this large amount of control system information to operators and engineers, IRMIS was initially built with nine Web-based viewers: Applications Organizing Index, IOC, PLC, Component Type, Installed Components, Network, Controls Spares, Process Variables, and Cables. However, since each viewer is designed to provide details from only one major category of the control system, the necessity for a one-stop global search tool for the entire database became apparent. The user requirements for extremely fast database search time and ease of navigation through search results led to the choice of Asynchronous JavaScript and XML (AJAX) technology in the implementation of the IRMIS global search tool. Unique features of the global search tool include a two-tier level of displayed search results, and a database data integrity validation and reporting mechanism.

  17. An Analysis of Energy Savings Possible Through Advances in Automotive Tooling Technology

    SciTech Connect

    Rick Schmoyer, RLS

    2004-12-03

    The use of lightweight and highly formable advanced materials in automobile and truck manufacturing has the potential to save fuel. Advances in tooling technology would promote the use of these materials. This report describes an energy savings analysis performed to approximate the potential fuel savings and consequential carbon-emission reductions that would be possible because of advances in tooling in the manufacturing of, in particular, non-powertrain components of passenger cars and heavy trucks. Separate energy analyses are performed for cars and heavy trucks. Heavy trucks are considered to be Class 7 and 8 trucks (trucks rated over 26,000 lbs gross vehicle weight). A critical input to the analysis is a set of estimates of the percentage reductions in weight and drag that could be achieved by the implementation of advanced materials, as a consequence of improved tooling technology, which were obtained by surveying tooling industry experts who attended a DOE Workshop, Tooling Technology for Low-Volume Vehicle Production, held in Seattle and Detroit in October and November 2003. The analysis is also based on 2001 fuel consumption totals and on energy-audit component proportions of fuel use due to drag, rolling resistance, and braking. The consumption proportions are assumed constant over time, but an allowance is made for fleet growth. The savings for a particular component is then the product of total fuel consumption, the percentage reduction of the component, and the energy audit component proportion. Fuel savings estimates for trucks also account for weight-limited versus volume-limited operations. Energy savings are assumed to be of two types: (1) direct energy savings incurred through reduced forces that must be overcome to move the vehicle or to slow it down in braking. and (2) indirect energy savings through reductions in the required engine power, the production and transmission of which incur thermodynamic losses, internal friction, and other

  18. Laser vision: lidar as a transformative tool to advance critical zone science

    NASA Astrophysics Data System (ADS)

    Harpold, A. A.; Marshall, J. A.; Lyon, S. W.; Barnhart, T. B.; Fisher, B.; Donovan, M.; Brubaker, K. M.; Crosby, C. J.; Glenn, N. F.; Glennie, C. L.; Kirchner, P. B.; Lam, N.; Mankoff, K. D.; McCreight, J. L.; Molotch, N. P.; Musselman, K. N.; Pelletier, J.; Russo, T.; Sangireddy, H.; Sjöberg, Y.; Swetnam, T.; West, N.

    2015-01-01

    Laser vision: lidar as a transformative tool to advance critical zone science. Observation and quantification of the Earth surface is undergoing a revolutionary change due to the increased spatial resolution and extent afforded by light detection and ranging (lidar) technology. As a consequence, lidar-derived information has led to fundamental discoveries within the individual disciplines of geomorphology, hydrology, and ecology. These disciplines form the cornerstones of Critical Zone (CZ) science, where researchers study how interactions among the geosphere, hydrosphere, and ecosphere shape and maintain the "zone of life", extending from the groundwater to the vegetation canopy. Lidar holds promise as a transdisciplinary CZ research tool by simultaneously allowing for quantification of topographic, vegetative, and hydrological data. Researchers are just beginning to utilize lidar datasets to answer synergistic questions in CZ science, such as how landforms and soils develop in space and time as a function of the local climate, biota, hydrologic properties, and lithology. This review's objective is to demonstrate the transformative potential of lidar by critically assessing both challenges and opportunities for transdisciplinary lidar applications. A review of 147 peer-reviewed studies utilizing lidar showed that 38 % of the studies were focused in geomorphology, 18 % in hydrology, 32 % in ecology, and the remaining 12 % have an interdisciplinary focus. We find that using lidar to its full potential will require numerous advances across CZ applications, including new and more powerful open-source processing tools, exploiting new lidar acquisition technologies, and improved integration with physically-based models and complementary in situ and remote-sensing observations. We provide a five-year vision to utilize and advocate for the expanded use of lidar datasets to benefit CZ science applications.

  19. Contemporary molecular tools in microbial ecology and their application to advancing biotechnology.

    PubMed

    Rashid, Mamoon; Stingl, Ulrich

    2015-12-01

    Novel methods in microbial ecology are revolutionizing our understanding of the structure and function of microbes in the environment, but concomitant advances in applications of these tools to biotechnology are mostly lagging behind. After more than a century of efforts to improve microbial culturing techniques, about 70-80% of microbial diversity - recently called the "microbial dark matter" - remains uncultured. In early attempts to identify and sample these so far uncultured taxonomic lineages, methods that amplify and sequence ribosomal RNA genes were extensively used. Recent developments in cell separation techniques, DNA amplification, and high-throughput DNA sequencing platforms have now made the discovery of genes/genomes of uncultured microorganisms from different environments possible through the use of metagenomic techniques and single-cell genomics. When used synergistically, these metagenomic and single-cell techniques create a powerful tool to study microbial diversity. These genomics techniques have already been successfully exploited to identify sources for i) novel enzymes or natural products for biotechnology applications, ii) novel genes from extremophiles, and iii) whole genomes or operons from uncultured microbes. More can be done to utilize these tools more efficiently in biotechnology.

  20. Development of Experimental and Computational Aeroacoustic Tools for Advanced Liner Evaluation

    NASA Technical Reports Server (NTRS)

    Jones, Michael G.; Watson, Willie R.; Nark, Douglas N.; Parrott, Tony L.; Gerhold, Carl H.; Brown, Martha C.

    2006-01-01

    Acoustic liners in aircraft engine nacelles suppress radiated noise. Therefore, as air travel increases, increasingly sophisticated tools are needed to maximize noise suppression. During the last 30 years, NASA has invested significant effort in development of experimental and computational acoustic liner evaluation tools. The Curved Duct Test Rig is a 152-mm by 381- mm curved duct that supports liner evaluation at Mach numbers up to 0.3 and source SPLs up to 140 dB, in the presence of user-selected modes. The Grazing Flow Impedance Tube is a 51- mm by 63-mm duct currently being fabricated to operate at Mach numbers up to 0.6 with source SPLs up to at least 140 dB, and will replace the existing 51-mm by 51-mm duct. Together, these test rigs allow evaluation of advanced acoustic liners over a range of conditions representative of those observed in aircraft engine nacelles. Data acquired with these test ducts are processed using three aeroacoustic propagation codes. Two are based on finite element solutions to convected Helmholtz and linearized Euler equations. The third is based on a parabolic approximation to the convected Helmholtz equation. The current status of these computational tools and their associated usage with the Langley test rigs is provided.

  1. Molecular tools for functional genomics in filamentous fungi: recent advances and new strategies.

    PubMed

    Jiang, Dewei; Zhu, Wei; Wang, Yunchuan; Sun, Chang; Zhang, Ke-Qin; Yang, Jinkui

    2013-12-01

    Advances in genetic transformation techniques have made important contributions to molecular genetics. Various molecular tools and strategies have been developed for functional genomic analysis of filamentous fungi since the first DNA transformation was successfully achieved in Neurospora crassa in 1973. Increasing amounts of genomic data regarding filamentous fungi are continuously reported and large-scale functional studies have become common in a wide range of fungal species. In this review, various molecular tools used in filamentous fungi are compared and discussed, including methods for genetic transformation (e.g., protoplast transformation, electroporation, and microinjection), the construction of random mutant libraries (e.g., restriction enzyme mediated integration, transposon arrayed gene knockout, and Agrobacterium tumefaciens mediated transformation), and the analysis of gene function (e.g., RNA interference and transcription activator-like effector nucleases). We also focused on practical strategies that could enhance the efficiency of genetic manipulation in filamentous fungi, such as choosing a proper screening system and marker genes, assembling target-cassettes or vectors effectively, and transforming into strains that are deficient in the nonhomologous end joining pathway. In summary, we present an up-to-date review on the different molecular tools and latest strategies that have been successfully used in functional genomics in filamentous fungi.

  2. Analytical tools employed to determine pharmaceutical compounds in wastewaters after application of advanced oxidation processes.

    PubMed

    Afonso-Olivares, Cristina; Montesdeoca-Esponda, Sarah; Sosa-Ferrera, Zoraida; Santana-Rodríguez, José Juan

    2016-12-01

    Today, the presence of contaminants in the environment is a topic of interest for society in general and for the scientific community in particular. A very large amount of different chemical substances reaches the environment after passing through wastewater treatment plants without being eliminated. This is due to the inefficiency of conventional removal processes and the lack of government regulations. The list of compounds entering treatment plants is gradually becoming longer and more varied because most of these compounds come from pharmaceuticals, hormones or personal care products, which are increasingly used by modern society. As a result of this increase in compound variety, to address these emerging pollutants, the development of new and more efficient removal technologies is needed. Different advanced oxidation processes (AOPs), especially photochemical AOPs, have been proposed as supplements to traditional treatments for the elimination of pollutants, showing significant advantages over the use of conventional methods alone. This work aims to review the analytical methodologies employed for the analysis of pharmaceutical compounds from wastewater in studies in which advanced oxidation processes are applied. Due to the low concentrations of these substances in wastewater, mass spectrometry detectors are usually chosen to meet the low detection limits and identification power required. Specifically, time-of-flight detectors are required to analyse the by-products.

  3. MEDECOR--a medical decorporation tool to assist first responders, receivers, and medical reach-back personnel in triage, treatment, and risk assessment after internalization of radionuclides.

    PubMed

    Waller, Ed; Wilkinson, Diana

    2010-10-01

    After a radiological dispersal device (RDD) event, it is possible for radionuclides to enter the human body through inhalation, ingestion, and skin and wound absorption. From a health physics perspective, it is important to know the magnitude of the intake to perform dosimetric assessments. From a medical perspective, removal of radionuclides leading to dose aversion (hence risk reduction) is of high importance. The efficacy of medical decorporation strategies is extremely dependent upon the time of treatment delivery after intake. The "golden hour," or more realistically 3-4 h, is optimal when attempting to increase removal of radionuclides from extracellular fluids prior to cellular incorporation. To assist medical first response personnel in making timely decisions regarding appropriate treatment delivery modes, it is desirable to have a software tool that compiles existing radionuclide decorporation therapy data and allows a user to perform simple diagnosis leading to optimized decorporation treatment strategies. In its most simple application, the software is a large database of radionuclide decorporation strategies and treatments. The software can also be used in clinical interactive mode, in which the user inputs the radionuclide, estimated activity, route of intake and time since exposure. The software makes suggestions as to the urgency of treatment (i.e., triage) and the suggested therapy. Current developments include risk assessment which impacts the potential risk of delivered therapy and resource allocation of therapeutic agents. The software, developed for the Canadian Department of National Defence (DND), is titled MEDECOR (MEdical DECORporation). The MEDECOR tool was designed for use on both personal digital assistant and laptop computer environments. The tool was designed using HTML/Jscript, to allow for ease of portability amongst different computing platforms. This paper presents the features of MEDECOR, results of testing at a major NATO

  4. A decision support tool for synchronizing technology advances with strategic mission objectives

    NASA Technical Reports Server (NTRS)

    Hornstein, Rhoda S.; Willoughby, John K.

    1992-01-01

    Successful accomplishment of the objectives of many long-range future missions in areas such as space systems, land-use planning, and natural resource management requires significant technology developments. This paper describes the development of a decision-support data-derived tool called MisTec for helping strategic planners to determine technology development alternatives and to synchronize the technology development schedules with the performance schedules of future long-term missions. Special attention is given to the operations, concept, design, and functional capabilities of the MisTec. The MisTec was initially designed for manned Mars mission, but can be adapted to support other high-technology long-range strategic planning situations, making it possible for a mission analyst, planner, or manager to describe a mission scenario, determine the technology alternatives for making the mission achievable, and to plan the R&D activity necessary to achieve the required technology advances.

  5. Advanced Launch Technology Life Cycle Analysis Using the Architectural Comparison Tool (ACT)

    NASA Technical Reports Server (NTRS)

    McCleskey, Carey M.

    2015-01-01

    Life cycle technology impact comparisons for nanolauncher technology concepts were performed using an Affordability Comparison Tool (ACT) prototype. Examined are cost drivers and whether technology investments can dramatically affect the life cycle characteristics. Primary among the selected applications was the prospect of improving nanolauncher systems. As a result, findings and conclusions are documented for ways of creating more productive and affordable nanolauncher systems; e.g., an Express Lane-Flex Lane concept is forwarded, and the beneficial effect of incorporating advanced integrated avionics is explored. Also, a Functional Systems Breakdown Structure (F-SBS) was developed to derive consistent definitions of the flight and ground systems for both system performance and life cycle analysis. Further, a comprehensive catalog of ground segment functions was created.

  6. Complex Spine Pathology Simulator: An Innovative Tool for Advanced Spine Surgery Training.

    PubMed

    Gragnaniello, Cristian; Abou-Hamden, Amal; Mortini, Pietro; Colombo, Elena V; Bailo, Michele; Seex, Kevin A; Litvack, Zachary; Caputy, Anthony J; Gagliardi, Filippo

    2016-11-01

    Background Technical advancements in spine surgery have made possible the treatment of increasingly complex pathologies with less morbidity. Time constraints in surgeons' training have made it necessary to develop new training models for spine pathology. Objective To describe the application of a novel compound, Stratathane resin ST-504 derived polymer (SRSDP), that can be injected at different spinal target locations to mimic spinal epidural, subdural extra-axial, and intra-axial pathologies for the use in advanced surgical training. Material and Methods Fresh-frozen thoracolumbar and cervical spine segments of human and sheep cadavers were used to study the model. SRSDP is initially liquid after mixing, allowing it to be injected into target areas where it expands and solidifies, mimicking the entire spectrum of spinal pathologies. Results Different polymer concentrations have been codified to vary adhesiveness, texture, spread capability, deformability, and radiologic visibility. Polymer injection was performed under fluoroscopic guidance through pathology-specific injection sites that avoided compromising the surgical approach for subsequent excision of the artificial lesion. Inflation of a balloon catheter of the desired size was used to displace stiff cadaveric neurovascular structures to mimic pathology-related mass effect. Conclusion The traditional cadaveric training models principally only allow surgeons to practice the surgical approach. The complex spine pathology simulator is a novel educational tool that in a user-friendly, low-cost fashion allows trainees to practice advanced technical skills in the removal of complex spine pathology, potentially shortening some of the aspects of the learning curve of operative skills that may otherwise take many years to acquire.

  7. DNA technological progress toward advanced diagnostic tools to support human hookworm control.

    PubMed

    Gasser, R B; Cantacessi, C; Loukas, A

    2008-01-01

    Blood-feeding hookworms are parasitic nematodes of major human health importance. Currently, it is estimated that 740 million people are infected worldwide, and more than 80 million of them are severely affected clinically by hookworm disease. In spite of the health problems caused and the advances toward the development of vaccines against some hookworms, limited attention has been paid to the need for improved, practical methods of diagnosis. Accurate diagnosis and genetic characterization of hookworms is central to their effective control. While traditional diagnostic methods have considerable limitations, there has been some progress toward the development of molecular-diagnostic tools. The present article provides a brief background on hookworm disease of humans, reviews the main methods that have been used for diagnosis and describes progress in establishing polymerase chain reaction (PCR)-based methods for the specific diagnosis of hookworm infection and the genetic characterisation of the causative agents. This progress provides a foundation for the rapid development of practical, highly sensitive and specific diagnostic and analytical tools to be used in improved hookworm prevention and control programmes.

  8. MATISSE: Multi-purpose Advanced Tool for Instruments for the Solar System Exploration .

    NASA Astrophysics Data System (ADS)

    Zinzi, A.; Capria, M. T.; Antonelli, L. A.

    In planetary sciences, design, assemble and launch onboard instruments are only preliminary steps toward the final aim of converting data into scientific knowledge, as the real challenge is the data analysis and interpretation. Up to now data have been generally stored in "old style" archives, i.e. common ftp servers where the user can manually search for data browsing directories organized in a time order manner. However, as datasets to be stored and searched become particularly large, this latter task absorbs a great part of the time, subtracting time to the real scientific work. In order to reduce the time spent to search and analyze data MATISSE (Multi-purpose Advanced Tool for Instruments for the Solar System Exploration), a new set of software tools developed together with the scientific teams of the instruments involved, is under development at ASDC (ASI Science Data Center), whose experience in space missions data management is well known (e.g., \\citealt{verrecchia07,pittori09,giommi09,massaro11}) and its features and aims will be presented here.

  9. Laser vision: lidar as a transformative tool to advance critical zone science

    NASA Astrophysics Data System (ADS)

    Harpold, A. A.; Marshall, J. A.; Lyon, S. W.; Barnhart, T. B.; Fisher, B. A.; Donovan, M.; Brubaker, K. M.; Crosby, C. J.; Glenn, N. F.; Glennie, C. L.; Kirchner, P. B.; Lam, N.; Mankoff, K. D.; McCreight, J. L.; Molotch, N. P.; Musselman, K. N.; Pelletier, J.; Russo, T.; Sangireddy, H.; Sjöberg, Y.; Swetnam, T.; West, N.

    2015-06-01

    Observation and quantification of the Earth's surface is undergoing a revolutionary change due to the increased spatial resolution and extent afforded by light detection and ranging (lidar) technology. As a consequence, lidar-derived information has led to fundamental discoveries within the individual disciplines of geomorphology, hydrology, and ecology. These disciplines form the cornerstones of critical zone (CZ) science, where researchers study how interactions among the geosphere, hydrosphere, and biosphere shape and maintain the "zone of life", which extends from the top of unweathered bedrock to the top of the vegetation canopy. Fundamental to CZ science is the development of transdisciplinary theories and tools that transcend disciplines and inform other's work, capture new levels of complexity, and create new intellectual outcomes and spaces. Researchers are just beginning to use lidar data sets to answer synergistic, transdisciplinary questions in CZ science, such as how CZ processes co-evolve over long timescales and interact over shorter timescales to create thresholds, shifts in states and fluxes of water, energy, and carbon. The objective of this review is to elucidate the transformative potential of lidar for CZ science to simultaneously allow for quantification of topographic, vegetative, and hydrological processes. A review of 147 peer-reviewed lidar studies highlights a lack of lidar applications for CZ studies as 38 % of the studies were focused in geomorphology, 18 % in hydrology, 32 % in ecology, and the remaining 12 % had an interdisciplinary focus. A handful of exemplar transdisciplinary studies demonstrate lidar data sets that are well-integrated with other observations can lead to fundamental advances in CZ science, such as identification of feedbacks between hydrological and ecological processes over hillslope scales and the synergistic co-evolution of landscape-scale CZ structure due to interactions amongst carbon, energy, and water cycles

  10. Development, Implementation and Application of Micromechanical Analysis Tools for Advanced High Temperature Composites

    NASA Technical Reports Server (NTRS)

    2005-01-01

    This document contains the final report to the NASA Glenn Research Center (GRC) for the research project entitled Development, Implementation, and Application of Micromechanical Analysis Tools for Advanced High-Temperature Composites. The research supporting this initiative has been conducted by Dr. Brett A. Bednarcyk, a Senior Scientist at OM in Brookpark, Ohio from the period of August 1998 to March 2005. Most of the work summarized herein involved development, implementation, and application of enhancements and new capabilities for NASA GRC's Micromechanics Analysis Code with Generalized Method of Cells (MAC/GMC) software package. When the project began, this software was at a low TRL (3-4) and at release version 2.0. Due to this project, the TRL of MAC/GMC has been raised to 7 and two new versions (3.0 and 4.0) have been released. The most important accomplishments with respect to MAC/GMC are: (1) A multi-scale framework has been built around the software, enabling coupled design and analysis from the global structure scale down to the micro fiber-matrix scale; (2) The software has been expanded to analyze smart materials; (3) State-of-the-art micromechanics theories have been implemented and validated within the code; (4) The damage, failure, and lifing capabilities of the code have been expanded from a very limited state to a vast degree of functionality and utility; and (5) The user flexibility of the code has been significantly enhanced. MAC/GMC is now the premier code for design and analysis of advanced composite and smart materials. It is a candidate for the 2005 NASA Software of the Year Award. The work completed over the course of the project is summarized below on a year by year basis. All publications resulting from the project are listed at the end of this report.

  11. A Bird's-eye View with X-ray Vision: Remote-sensing tools to Monitor Reach-scale Response to Dam Removal on the Elwha River

    NASA Astrophysics Data System (ADS)

    Ritchie, A. C.

    2012-12-01

    Repeat digital surface models, orthoimagery and sidescan sonar data are being generated to monitor river response to the largest dam removal and controlled sediment release in history on the Elwha River, on the Olympic Peninsula in Washington State. These products are generated using low-cost readily-available tools to collect data at a spatial and temporal scale that provides important insight into effects of base-level change, sediment release, and discrete hydrologic events on erosion of reservoir sediments, downstream sediment transport, and channel evolution above and below the dam sites. In combination, these products provide a view above and below the water surface to changes in sediment composition and morphology that other methods cannot capture at this spatial scale and both spatial and temporal resolution. Orthoimagery is developed from still images collected with a plane-mounted point-and-shoot camera using customized firmware from the open-source Canon Hack Development Kit (CHDK) with a total hardware cost of about $300 USD. Images are processed using structure-from-motion algorithms. Several software options are available. Sonar data are collected from a raft-mounted platform using a high-resolution 990 KHz Starfish sidescan sonar, with a water-resistant topside enclosure holding top-side electronics. A steerable pole-mount was developed for this application to allow the sidescan to to remain oriented in the direction of motion-over-ground.; Surface reconstruction from aerial images collected during Elwha dam removal project. ; bedforms near Elwha Sediment Treatment Plant from sediment released from Lake Aldwell, surveyed 12 July 2012.

  12. NASA Advanced Concepts Office, Earth-To-Orbit Team Design Process and Tools

    NASA Technical Reports Server (NTRS)

    Waters, Eric D.; Garcia, Jessica; Threet, Grady E., Jr.; Phillips, Alan

    2013-01-01

    The Earth-to-Orbit Team (ETO) of the Advanced Concepts Office (ACO) at NASA Marshall Space Flight Center (MSFC) is considered the pre-eminent "go-to" group for pre-phase A and phase A concept definition. Over the past several years the ETO team has evaluated thousands of launch vehicle concept variations for a significant number of studies including agency-wide efforts such as the Exploration Systems Architecture Study (ESAS), Constellation, Heavy Lift Launch Vehicle (HLLV), Augustine Report, Heavy Lift Propulsion Technology (HLPT), Human Exploration Framework Team (HEFT), and Space Launch System (SLS). The ACO ETO Team is called upon to address many needs in NASA's design community; some of these are defining extremely large trade-spaces, evaluating advanced technology concepts which have not been addressed by a large majority of the aerospace community, and the rapid turn-around of highly time critical actions. It is the time critical actions, those often limited by schedule or little advanced warning, that have forced the five member ETO team to develop a design process robust enough to handle their current output level in order to meet their customer's needs. Based on the number of vehicle concepts evaluated over the past year this output level averages to four completed vehicle concepts per day. Each of these completed vehicle concepts includes a full mass breakdown of the vehicle to a tertiary level of subsystem components and a vehicle trajectory analysis to determine optimized payload delivery to specified orbital parameters, flight environments, and delta v capability. A structural analysis of the vehicle to determine flight loads based on the trajectory output, material properties, and geometry of the concept is also performed. Due to working in this fast-paced and sometimes rapidly changing environment, the ETO Team has developed a finely tuned process to maximize their delivery capabilities. The objective of this paper is to describe the interfaces

  13. NASA Advanced Concepts Office, Earth-To-Orbit Team Design Process and Tools

    NASA Technical Reports Server (NTRS)

    Waters, Eric D.; Creech, Dennis M.; Garcia, Jessica; Threet, Grady E., Jr.; Phillips, Alan

    2012-01-01

    The Earth-to-Orbit Team (ETO) of the Advanced Concepts Office (ACO) at NASA Marshall Space Flight Center (MSFC) is considered the pre-eminent go-to group for pre-phase A and phase A concept definition. Over the past several years the ETO team has evaluated thousands of launch vehicle concept variations for a significant number of studies including agency-wide efforts such as the Exploration Systems Architecture Study (ESAS), Constellation, Heavy Lift Launch Vehicle (HLLV), Augustine Report, Heavy Lift Propulsion Technology (HLPT), Human Exploration Framework Team (HEFT), and Space Launch System (SLS). The ACO ETO Team is called upon to address many needs in NASA s design community; some of these are defining extremely large trade-spaces, evaluating advanced technology concepts which have not been addressed by a large majority of the aerospace community, and the rapid turn-around of highly time critical actions. It is the time critical actions, those often limited by schedule or little advanced warning, that have forced the five member ETO team to develop a design process robust enough to handle their current output level in order to meet their customer s needs. Based on the number of vehicle concepts evaluated over the past year this output level averages to four completed vehicle concepts per day. Each of these completed vehicle concepts includes a full mass breakdown of the vehicle to a tertiary level of subsystem components and a vehicle trajectory analysis to determine optimized payload delivery to specified orbital parameters, flight environments, and delta v capability. A structural analysis of the vehicle to determine flight loads based on the trajectory output, material properties, and geometry of the concept is also performed. Due to working in this fast-paced and sometimes rapidly changing environment, the ETO Team has developed a finely tuned process to maximize their delivery capabilities. The objective of this paper is to describe the interfaces

  14. How Project Management Tools Aid in Association to Advance Collegiate Schools of Business (AACSB) International Maintenance of Accreditation

    ERIC Educational Resources Information Center

    Cann, Cynthia W.; Brumagim, Alan L.

    2008-01-01

    The authors present the case of one business college's use of project management techniques as tools for accomplishing Association to Advance Collegiate Schools of Business (AACSB) International maintenance of accreditation. Using these techniques provides an efficient and effective method of organizing maintenance efforts. In addition, using…

  15. Advances in the genetic dissection of plant cell walls: tools and resources available in Miscanthus

    PubMed Central

    Slavov, Gancho; Allison, Gordon; Bosch, Maurice

    2013-01-01

    Tropical C4 grasses from the genus Miscanthus are believed to have great potential as biomass crops. However, Miscanthus species are essentially undomesticated, and genetic, molecular and bioinformatics tools are in very early stages of development. Furthermore, similar to other crops targeted as lignocellulosic feedstocks, the efficient utilization of biomass is hampered by our limited knowledge of the structural organization of the plant cell wall and the underlying genetic components that control this organization. The Institute of Biological, Environmental and Rural Sciences (IBERS) has assembled an extensive collection of germplasm for several species of Miscanthus. In addition, an integrated, multidisciplinary research programme at IBERS aims to inform accelerated breeding for biomass productivity and composition, while also generating fundamental knowledge. Here we review recent advances with respect to the genetic characterization of the cell wall in Miscanthus. First, we present a summary of recent and on-going biochemical studies, including prospects and limitations for the development of powerful phenotyping approaches. Second, we review current knowledge about genetic variation for cell wall characteristics of Miscanthus and illustrate how phenotypic data, combined with high-density arrays of single-nucleotide polymorphisms, are being used in genome-wide association studies to generate testable hypotheses and guide biological discovery. Finally, we provide an overview of the current knowledge about the molecular biology of cell wall biosynthesis in Miscanthus and closely related grasses, discuss the key conceptual and technological bottlenecks, and outline the short-term prospects for progress in this field. PMID:23847628

  16. Ares First Stage "Systemology" - Combining Advanced Systems Engineering and Planning Tools to Assure Mission Success

    NASA Technical Reports Server (NTRS)

    Seiler, James; Brasfield, Fred; Cannon, Scott

    2008-01-01

    Ares is an integral part of NASA s Constellation architecture that will provide crew and cargo access to the International Space Station as well as low earth orbit support for lunar missions. Ares replaces the Space Shuttle in the post 2010 time frame. Ares I is an in-line, two-stage rocket topped by the Orion Crew Exploration Vehicle, its service module, and a launch abort system. The Ares I first stage is a single, five-segment reusable solid rocket booster derived from the Space Shuttle Program's reusable solid rocket motor. The Ares second or upper stage is propelled by a J-2X main engine fueled with liquid oxygen and liquid hydrogen. This paper describes the advanced systems engineering and planning tools being utilized for the design, test, and qualification of the Ares I first stage element. Included are descriptions of the current first stage design, the milestone schedule requirements, and the marriage of systems engineering, detailed planning efforts, and roadmapping employed to achieve these goals.

  17. Predictive Modeling of Estrogen Receptor Binding Agents Using Advanced Cheminformatics Tools and Massive Public Data

    PubMed Central

    Ribay, Kathryn; Kim, Marlene T.; Wang, Wenyi; Pinolini, Daniel; Zhu, Hao

    2016-01-01

    Estrogen receptors (ERα) are a critical target for drug design as well as a potential source of toxicity when activated unintentionally. Thus, evaluating potential ERα binding agents is critical in both drug discovery and chemical toxicity areas. Using computational tools, e.g., Quantitative Structure-Activity Relationship (QSAR) models, can predict potential ERα binding agents before chemical synthesis. The purpose of this project was to develop enhanced predictive models of ERα binding agents by utilizing advanced cheminformatics tools that can integrate publicly available bioassay data. The initial ERα binding agent data set, consisting of 446 binders and 8307 non-binders, was obtained from the Tox21 Challenge project organized by the NIH Chemical Genomics Center (NCGC). After removing the duplicates and inorganic compounds, this data set was used to create a training set (259 binders and 259 non-binders). This training set was used to develop QSAR models using chemical descriptors. The resulting models were then used to predict the binding activity of 264 external compounds, which were available to us after the models were developed. The cross-validation results of training set [Correct Classification Rate (CCR) = 0.72] were much higher than the external predictivity of the unknown compounds (CCR = 0.59). To improve the conventional QSAR models, all compounds in the training set were used to search PubChem and generate a profile of their biological responses across thousands of bioassays. The most important bioassays were prioritized to generate a similarity index that was used to calculate the biosimilarity score between each two compounds. The nearest neighbors for each compound within the set were then identified and its ERα binding potential was predicted by its nearest neighbors in the training set. The hybrid model performance (CCR = 0.94 for cross validation; CCR = 0.68 for external prediction) showed significant improvement over the original QSAR

  18. The Advanced Dementia Prognostic Tool (ADEPT): A Risk Score to Estimate Survival in Nursing Home Residents with Advanced Dementia

    PubMed Central

    Mitchell, Susan L.; Miller, Susan C.; Teno, Joan M.; Davis, Roger B.; Shaffer, Michele L.

    2010-01-01

    Context Estimating life expectancy is challenging in advanced dementia. Objectives To create a risk score to estimate survival in nursing home (NH) residents with advanced dementia. Methods This was a retrospective cohort study performed in the setting of all licensed US NHs. Residents with advanced dementia living in US NHs in 2002 were identified using Minimum Data Set (MDS) assessments. Mortality data from Medicare files were used to determine 12-month survival. Independent variables were selected from the MDS. Cox proportional hazards regression was used to model survival. The accuracy of the final model was assessed using the area under the receiver operating characteristic curve (AUROC). To develop a risk score, points were assigned to variables in the final model based on parameter estimates. Residents meeting hospice eligibility guidelines for dementia, based on MDS data, were identified. The AUROC assessed the accuracy of hospice guidelines to predict six-month survival. Results Over 12 months, 40.6% of residents with advanced dementia (n=22,405) died. Twelve variables best predicted survival: length of stay, age, male, dyspnea, pressure ulcers, total functional dependence, bedfast, insufficient intake, bowel incontinence, body mass index, weight loss, and congestive heart failure. The AUROC for the final model was 0.68. The risk score ranged from 0–32 points (higher scores indicate worse survival). Only 15.9% of residents met hospice eligibility guidelines for which the AUROC predicting six-month survival was 0.53. Conclusion A mortality risk score derived from MDS data predicted six-month survival in advanced dementia with moderate accuracy. The predictive ability of hospice guidelines, simulated with MDS data, was poor. PMID:20621437

  19. Advanced Differential Radar Interferometry (A-DInSAR) as integrative tool for a structural geological analysis

    NASA Astrophysics Data System (ADS)

    Crippa, B.; Calcagni, L.; Rossi, G.; Sternai, P.

    2009-04-01

    Advanced Differential SAR interferometry (A-DInSAR) is a technique monitoring large-coverage surface deformations using a stack of interferograms generated from several complex SLC SAR images, acquired over the same target area at different times. In this work are described the results of a procedure to calculate terrain motion velocity on highly correlated pixels (E. Biescas, M. Crosetto, M. Agudo, O. Monserrat e B. Crippa: Two Radar Interferometric Approaches to Monitor Slow and Fast Land Deformation, 2007) in two area Gemona - Friuli, Northern Italy, Pollino - Calabria, Southern Italy, and, furthermore, are presented some consideration, based on successful examples of the present analysis. The choice of these pixels whose displacement velocity is calculated depends on the dispersion index value (DA) or using coherence values along the stack interferograms. A-DInSAR technique allows to obtain highly reliable velocity values of the vertical displacement. These values concern the movement of minimum surfaces of about 80m2 at the maximum resolution and the minimum velocity that can be recognized is of the order of mm/y. Because of the high versatility of the technology, because of the large dimensions of the area that can be analyzed (of about 10000Km2) and because of the high precision and reliability of the results obtained, we think it is possible to exploit radar interferometry to obtain some important information about the structural context of the studied area, otherwise very difficult to recognize. Therefore we propose radar interferometry as a valid investigation tool whose results must be considered as an important integration of the data collected in fieldworks.

  20. Development of 3D multimedia with advanced computer animation tools for outreach activities related to Meteor Science and Meteoritics

    NASA Astrophysics Data System (ADS)

    Madiedo, J. M.

    2012-09-01

    Documentaries related to Astronomy and Planetary Sciences are a common and very attractive way to promote the interest of the public in these areas. These educational tools can get benefit from new advanced computer animation software and 3D technologies, as these allow making these documentaries even more attractive. However, special care must be taken in order to guarantee that the information contained in them is serious and objective. In this sense, an additional value is given when the footage is produced by the own researchers. With this aim, a new documentary produced and directed by Prof. Madiedo has been developed. The documentary, which has been entirely developed by means of advanced computer animation tools, is dedicated to several aspects of Meteor Science and Meteoritics. The main features of this outreach and education initiative are exposed here.

  1. Update on ORNL TRANSFORM Tool: Simulating Multi-Module Advanced Reactor with End-to-End I&C

    SciTech Connect

    Hale, Richard Edward; Fugate, David L.; Cetiner, Sacit M.; Qualls, A. L.

    2015-05-01

    The Small Modular Reactor (SMR) Dynamic System Modeling Tool project is in the fourth year of development. The project is designed to support collaborative modeling and study of various advanced SMR (non-light water cooled reactor) concepts, including the use of multiple coupled reactors at a single site. The focus of this report is the development of a steam generator and drum system model that includes the complex dynamics of typical steam drum systems, the development of instrumentation and controls for the steam generator with drum system model, and the development of multi-reactor module models that reflect the full power reactor innovative small module design concept. The objective of the project is to provide a common simulation environment and baseline modeling resources to facilitate rapid development of dynamic advanced reactor models; ensure consistency among research products within the Instrumentation, Controls, and Human-Machine Interface technical area; and leverage cross-cutting capabilities while minimizing duplication of effort. The combined simulation environment and suite of models are identified as the TRANSFORM tool. The critical elements of this effort include (1) defining a standardized, common simulation environment that can be applied throughout the Advanced Reactors Technology program; (2) developing a library of baseline component modules that can be assembled into full plant models using available geometry, design, and thermal-hydraulic data; (3) defining modeling conventions for interconnecting component models; and (4) establishing user interfaces and support tools to facilitate simulation development (i.e., configuration and parameterization), execution, and results display and capture.

  2. Severe Impairment Rating Scale: A Useful and Brief Cognitive Assessment Tool for Advanced Dementia for Nursing Home Residents.

    PubMed

    Yeo, Cindy; Lim, Wee Shiong; Chan, Mark; Ho, Xin Qin; Anthony, Philomena Vasantha; Han, Huey Charn; Chong, Mei Sian

    2016-02-01

    To investigate the utility of the Severe Impairment Rating Scale (SIRS) as a cognitive assessment tool among nursing home residents with advanced dementia, we conducted a cross-sectional study of 96 residents in 3 nursing homes with Functional Assessment Staging Test (FAST) stage 6a and above. We compared the discriminatory ability of SIRS with the Chinese version of Mini-Mental State Examination, Abbreviated Mental Test, and Clock Drawing Test. Among the cognitive tests, SIRS showed the least "floor" effect and had the best capacity to distinguish very severe (FAST stages 7d-f) dementia (area under the curve 0.80 vs 0.46-0.76 for the other tools). The SIRS had the best correlation with FAST staging (r = -.59, P < .01) and, unlike the other 3 tools, exhibited only minimal change in correlation when adjusted for education and ethnicity. Our results support the utility of SIRS as a brief cognitive assessment tool for advanced dementia in the nursing home setting.

  3. Advances in Chimera Grid Tools for Multi-Body Dynamics Simulations and Script Creation

    NASA Technical Reports Server (NTRS)

    Chan, William M.

    2004-01-01

    This viewgraph presentation contains information about (1) Framework for multi-body dynamics - Geometry Manipulation Protocol (GMP), (2) Simulation procedure using Chimera Grid Tools (CGT) and OVERFLOW-2 (3) Further recent developments in Chimera Grid Tools OVERGRID, Grid modules, Script library and (4) Future work.

  4. Development of Advanced Life Prediction Tools for Elastic-Plastic Fatigue Crack Growth

    NASA Technical Reports Server (NTRS)

    Gregg, Wayne; McGill, Preston; Swanson, Greg; Wells, Doug; Throckmorton, D. A. (Technical Monitor)

    2001-01-01

    The objective of this viewgraph presentation is to develop a systematic approach to improving the fracture control process, including analytical tools, standards, guidelines, and awareness. Analytical tools specifically for elastic-plastic fracture analysis is a regime that is currently empirical for the Space Shuttle External Tank (ET) and is handled by simulated service testing of pre-cracked panels.

  5. Advancing Research in Second Language Writing through Computational Tools and Machine Learning Techniques: A Research Agenda

    ERIC Educational Resources Information Center

    Crossley, Scott A.

    2013-01-01

    This paper provides an agenda for replication studies focusing on second language (L2) writing and the use of natural language processing (NLP) tools and machine learning algorithms. Specifically, it introduces a range of the available NLP tools and machine learning algorithms and demonstrates how these could be used to replicate seminal studies…

  6. CBOs: Reaching the Hardest to Reach.

    ERIC Educational Resources Information Center

    BCEL Newsletter for the Business Community, 1986

    1986-01-01

    The agents most successful in reaching and teaching those most in need of basic skills instruction are the community-based organizations (CBOs). They come into being in response to social and economic problems faced by their constituents--disadvantaged minorities, the poor, the unemployed, and the alienated. Because of their close ties to the…

  7. Technologic advances in surgery for brain tumors: tools of the trade in the modern neurosurgical operating room.

    PubMed

    McPherson, Christopher M; Sawaya, Raymond

    2005-09-01

    Surgery is an essential part of the oncologic treatment of patients with brain tumors. Surgery is necessary for histologic diagnosis, and the cytoreduction of tumor mass has been shown to improve patient survival time and quality of life. Ultimately, the goal of any oncologic neurosurgery is to achieve maximal safe resection. Over the years, many technologic adjuncts have been developed to assist the surgeon in achieving this goal. In this article, we review the technologic advances of modern neurosurgery that are helping to reach this goal.

  8. ADVANCED TOOLS FOR ASSESSING SELECTED PRESCRIPTION AND ILLICIT DRUGS IN TREATED SEWAGE EFFLUENTS AND SOURCE WATERS

    EPA Science Inventory

    The purpose of this poster is to present the application and assessment of advanced technologies in a real-world environment - wastewater effluent and source waters - for detecting six drugs (azithromycin, fluoxetine, omeprazole, levothyroxine, methamphetamine, and methylenedioxy...

  9. CRISPR/Cas9: an advanced tool for editing plant genomes.

    PubMed

    Samanta, Milan Kumar; Dey, Avishek; Gayen, Srimonta

    2016-10-01

    To meet current challenges in agriculture, genome editing using sequence-specific nucleases (SSNs) is a powerful tool for basic and applied plant biology research. Here, we describe the principle and application of available genome editing tools, including zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and the clustered regularly interspaced short palindromic repeat associated CRISPR/Cas9 system. Among these SSNs, CRISPR/Cas9 is the most recently characterized and rapidly developing genome editing technology, and has been successfully utilized in a wide variety of organisms. This review specifically illustrates the power of CRISPR/Cas9 as a tool for plant genome engineering, and describes the strengths and weaknesses of the CRISPR/Cas9 technology compared to two well-established genome editing tools, ZFNs and TALENs.

  10. Advanced repair solution of clear defects on HTPSM by using nanomachining tool

    NASA Astrophysics Data System (ADS)

    Lee, Hyemi; Kim, Munsik; Jung, Hoyong; Kim, Sangpyo; Yim, Donggyu

    2015-10-01

    As the mask specifications become tighter for low k1 lithography, more aggressive repair accuracy is required below sub 20nm tech. node. To meet tight defect specifications, many maskshops select effective repair tools according to defect types. Normally, pattern defects are repaired by the e-beam repair tool and soft defects such as particles are repaired by the nanomachining tool. It is difficult for an e-beam repair tool to remove particle defects because it uses chemical reaction between gas and electron, and a nanomachining tool, which uses physical reaction between a nano-tip and defects, cannot be applied for repairing clear defects. Generally, film deposition process is widely used for repairing clear defects. However, the deposited film has weak cleaning durability, so it is easily removed by accumulated cleaning process. Although the deposited film is strongly attached on MoSiN(or Qz) film, the adhesive strength between deposited Cr film and MoSiN(or Qz) film becomes weaker and weaker by the accumulated energy when masks are exposed in a scanner tool due to the different coefficient of thermal expansion of each materials. Therefore, whenever a re-pellicle process is needed to a mask, all deposited repair points have to be confirmed whether those deposition film are damaged or not. And if a deposition point is damaged, repair process is needed again. This process causes longer and more complex process. In this paper, the basic theory and the principle are introduced to recover clear defects by using nanomachining tool, and the evaluated results are reviewed at dense line (L/S) patterns and contact hole (C/H) patterns. Also, the results using a nanomachining were compared with those using an e-beam repair tool, including the cleaning durability evaluated by the accumulated cleaning process. Besides, we discuss the phase shift issue and the solution about the image placement error caused by phase error.

  11. Development of Advanced Computational Aeroelasticity Tools at NASA Langley Research Center

    NASA Technical Reports Server (NTRS)

    Bartels, R. E.

    2008-01-01

    NASA Langley Research Center has continued to develop its long standing computational tools to address new challenges in aircraft and launch vehicle design. This paper discusses the application and development of those computational aeroelastic tools. Four topic areas will be discussed: 1) Modeling structural and flow field nonlinearities; 2) Integrated and modular approaches to nonlinear multidisciplinary analysis; 3) Simulating flight dynamics of flexible vehicles; and 4) Applications that support both aeronautics and space exploration.

  12. Advances in stroke treatment are within reach.

    PubMed

    Taylor, Allan; Le Feuvre, David; Mngomezulu, Victor; Royston, Duncan; Harrichandparsard, Rohen; De Vries, Coert; Winter, Arthur; Potgieter, Francois

    2016-03-30

    Five recent trials have shown that mechanical removal of clot from cerebral arteries after a stroke can achieve a functional independent outcome in up to 60% of patients. This was an absolute benefit of between 13.5% and 31% for patients who had clot removal initiated within 6 hours of symptoms over those who had best medical treatment. Coupled with this, there is a strong drive to develop stroke units internationally and in South Africa. As a starting point, more primary stroke care centres that can administer intravenous thrombolysis are needed. Comprehensive stroke centres that can offer mechanical thrombectomy are available, but more will be required as referral of patients increases. Collaboration of all roleplayers will ensure that we can deliver training and care at the best level for stroke patients.

  13. Implementation of a professional portfolio: a tool to demonstrate professional development for advanced practice.

    PubMed

    Chamblee, Tracy B; Dale, Juanita Conkin; Drews, Barbie; Spahis, Joanna; Hardin, Teri

    2015-01-01

    The literature has a gap related to professional development for APRNs. In the United States, many health care organizations use clinical advancement programs for registered nurses, but APRNs are not often included in these programs. If APRNs are included, advancement opportunities are very limited. At CMC, implementation of a professional portfolio resulted in increased satisfaction among APPs regarding their ability to showcase professional growth and expertise, as well as the uniqueness of their advanced practice. Use of the professional portfolio led to improved recognition by APS and organizational leaders of APP performance excellence during the annual performance evaluation, as well as improved recognition among APP colleagues in terms of nominations for honors and awards.

  14. New methodology to baseline and match AME polysilicon etcher using advanced diagnostic tools

    NASA Astrophysics Data System (ADS)

    Poppe, James; Shipman, John; Reinhardt, Barbara E.; Roussel, Myriam; Hedgecock, Raymond; Fonda, Arturo

    1999-09-01

    As process controls tighten in the semiconductor industry, the need to understand the variables that determine system performance become more important. For plasma etch systems, process success depends on the control of key parameters such as: vacuum integrity, pressure, gas flows, and RF power. It is imperative to baseline, monitor, and control these variables. This paper presents an overview of the methods and tools used by Motorola BMC fabrication facility to characterize an Applied Materials polysilicon etcher. Tool performance data obtained from our traditional measurement techniques are limited in their scope and do not provide a complete picture of the ultimate tool performance. Presently the BMC traditional characterization tools provide a snapshot of the static operation of the equipment under test (EUT); however, complete evaluation of the dynamic performance cannot be monitored without the aid of specialized diagnostic equipment. To provide us with a complete system baseline evaluation of the polysilicon etcher, three diagnostic tools were utilized: Lucas Labs Vacuum Diagnostic System, Residual Gas Analyzer, and the ENI Voltage/Impedance Probe. The diagnostic methodology used to baseline and match key parameters of qualified production equipment has had an immense impact on other equipment characterization in the facility. It has resulted in reduced cycle time for new equipment introduction as well.

  15. ADVANCED TOOLS FOR ASSESSING SELECTED PRESCRIPTION AND ILLICIT DRUGS IN TREATED SEWAGE EFFLUENTS AND SOURCE WATERS

    EPA Science Inventory

    The purpose of this poster is to present the application and assessment of advanced state-of-the-art technologies in a real-world environment - wastewater effluent and source waters - for detecting six drugs [azithromycin, fluoxetine, omeprazole, levothyroxine, methamphetamine, m...

  16. Just-in-Time Teaching: A Tool for Enhancing Student Engagement in Advanced Foreign Language Learning

    ERIC Educational Resources Information Center

    Abreu, Laurel; Knouse, Stephanie

    2014-01-01

    Scholars have indicated a need for further research on effective pedagogical strategies designed for advanced foreign language courses in the postsecondary setting, especially in light of decreased enrollments at this level and the elimination of foreign language programs altogether in some institutions (Paesani & Allen, 2012). This article…

  17. Advanced Technologies as Educational Tools in Science: Concepts, Applications, and Issues. Monograph Series Number 8.

    ERIC Educational Resources Information Center

    Kumar, David D.; And Others

    Systems incorporating two advanced technologies, hypermedia systems and intelligent tutors, are examined with respect to their potential impact on science education. The conceptual framework underlying these systems is discussed first. Applications of systems are then presented with examples of each in operation within the context of science…

  18. Genetic tools for advancement of Synechococcus sp. PCC 7002 as a cyanobacterial chassis

    DOE PAGES

    Ruffing, Anne M.; Jensen, Travis J.; Strickland, Lucas M.

    2016-11-10

    Successful implementation of modified cyanobacteria as hosts for industrial applications requires the development of a cyanobacterial chassis. The cyanobacterium Synechococcus sp. PCC 7002 embodies key attributes for an industrial host, including a fast growth rate and high salt, light, and temperature tolerances. Here, this study addresses key limitations in the advancement of Synechococcus sp. PCC 7002 as an industrial chassis.

  19. Teaching Advanced Concepts in Computer Networks: VNUML-UM Virtualization Tool

    ERIC Educational Resources Information Center

    Ruiz-Martinez, A.; Pereniguez-Garcia, F.; Marin-Lopez, R.; Ruiz-Martinez, P. M.; Skarmeta-Gomez, A. F.

    2013-01-01

    In the teaching of computer networks the main problem that arises is the high price and limited number of network devices the students can work with in the laboratories. Nowadays, with virtualization we can overcome this limitation. In this paper, we present a methodology that allows students to learn advanced computer network concepts through…

  20. Recent advances in microbial production of fuels and chemicals using tools and strategies of systems metabolic engineering.

    PubMed

    Cho, Changhee; Choi, So Young; Luo, Zi Wei; Lee, Sang Yup

    2015-11-15

    The advent of various systems metabolic engineering tools and strategies has enabled more sophisticated engineering of microorganisms for the production of industrially useful fuels and chemicals. Advances in systems metabolic engineering have been made in overproducing natural chemicals and producing novel non-natural chemicals. In this paper, we review the tools and strategies of systems metabolic engineering employed for the development of microorganisms for the production of various industrially useful chemicals belonging to fuels, building block chemicals, and specialty chemicals, in particular focusing on those reported in the last three years. It was aimed at providing the current landscape of systems metabolic engineering and suggesting directions to address future challenges towards successfully establishing processes for the bio-based production of fuels and chemicals from renewable resources.

  1. Towards the characterization of noise sources in a supersonic three-stream jet using advanced analysis tools

    NASA Astrophysics Data System (ADS)

    Ruscher, Christopher; Gogineni, Sivaram

    2016-11-01

    Strict noise regulation set by governing bodies currently make supersonic commercial aviation impractical. One of the many challenges that exist in developing practical supersonic commercial aircraft is the noise produced by the engine's exhaust jet. A promising method of jet noise reduction for supersonic applications is through the addition of extra exhaust streams. Data for an axisymmetric three-stream nozzle were generated using the Naval Research Laboratory's JENRE code. This data will be compared to experimental results obtained by NASA for validation purposes. Once the simulation results show satisfactory agreement to the experiments, advanced analysis tools will be applied to the simulation data to characterize potential noise sources. The tools to be applied include methods that are based on proper orthogonal decomposition, wavelet decomposition, and stochastic estimation. Additionally, techniques such as empirical mode decomposition and momentum potential theorem will be applied to the data as well.

  2. Advanced Algorithms and Automation Tools for Discrete Ordinates Methods in Parallel Environments

    SciTech Connect

    Alireza Haghighat

    2003-05-07

    This final report discusses major accomplishments of a 3-year project under the DOE's NEER Program. The project has developed innovative and automated algorithms, codes, and tools for solving the discrete ordinates particle transport method efficiently in parallel environments. Using a number of benchmark and real-life problems, the performance and accuracy of the new algorithms have been measured and analyzed.

  3. Continuous Symmetry and Chemistry Teachers: Learning Advanced Chemistry Content through Novel Visualization Tools

    ERIC Educational Resources Information Center

    Tuvi-Arad, Inbal; Blonder, Ron

    2010-01-01

    In this paper we describe the learning process of a group of experienced chemistry teachers in a specially designed workshop on molecular symmetry and continuous symmetry. The workshop was based on interactive visualization tools that allow molecules and their symmetry elements to be rotated in three dimensions. The topic of continuous symmetry is…

  4. Advances in Omics and Bioinformatics Tools for Systems Analyses of Plant Functions

    PubMed Central

    Mochida, Keiichi; Shinozaki, Kazuo

    2011-01-01

    Omics and bioinformatics are essential to understanding the molecular systems that underlie various plant functions. Recent game-changing sequencing technologies have revitalized sequencing approaches in genomics and have produced opportunities for various emerging analytical applications. Driven by technological advances, several new omics layers such as the interactome, epigenome and hormonome have emerged. Furthermore, in several plant species, the development of omics resources has progressed to address particular biological properties of individual species. Integration of knowledge from omics-based research is an emerging issue as researchers seek to identify significance, gain biological insights and promote translational research. From these perspectives, we provide this review of the emerging aspects of plant systems research based on omics and bioinformatics analyses together with their associated resources and technological advances. PMID:22156726

  5. Genetic tools for advancement of Synechococcus sp. PCC 7002 as a cyanobacterial chassis

    SciTech Connect

    Ruffing, Anne M.; Jensen, Travis J.; Strickland, Lucas M.

    2016-11-10

    Successful implementation of modified cyanobacteria as hosts for industrial applications requires the development of a cyanobacterial chassis. The cyanobacterium Synechococcus sp. PCC 7002 embodies key attributes for an industrial host, including a fast growth rate and high salt, light, and temperature tolerances. Here, this study addresses key limitations in the advancement of Synechococcus sp. PCC 7002 as an industrial chassis.

  6. Using Enabling Technologies to Advance Data Intensive Analysis Tools in the JPL Tropical Cyclone Information System

    NASA Astrophysics Data System (ADS)

    Knosp, B.; Gangl, M. E.; Hristova-Veleva, S. M.; Kim, R. M.; Lambrigtsen, B.; Li, P.; Niamsuwan, N.; Shen, T. P. J.; Turk, F. J.; Vu, Q. A.

    2014-12-01

    The JPL Tropical Cyclone Information System (TCIS) brings together satellite, aircraft, and model forecast data from several NASA, NOAA, and other data centers to assist researchers in comparing and analyzing data related to tropical cyclones. The TCIS has been supporting specific science field campaigns, such as the Genesis and Rapid Intensification Processes (GRIP) campaign and the Hurricane and Severe Storm Sentinel (HS3) campaign, by creating near real-time (NRT) data visualization portals. These portals are intended to assist in mission planning, enhance the understanding of current physical processes, and improve model data by comparing it to satellite and aircraft observations. The TCIS NRT portals allow the user to view plots on a Google Earth interface. To compliment these visualizations, the team has been working on developing data analysis tools to let the user actively interrogate areas of Level 2 swath and two-dimensional plots they see on their screen. As expected, these observation and model data are quite voluminous and bottlenecks in the system architecture can occur when the databases try to run geospatial searches for data files that need to be read by the tools. To improve the responsiveness of the data analysis tools, the TCIS team has been conducting studies on how to best store Level 2 swath footprints and run sub-second geospatial searches to discover data. The first objective was to improve the sampling accuracy of the footprints being stored in the TCIS database by comparing the Java-based NASA PO.DAAC Level 2 Swath Generator with a TCIS Python swath generator. The second objective was to compare the performance of four database implementations - MySQL, MySQL+Solr, MongoDB, and PostgreSQL - to see which database management system would yield the best geospatial query and storage performance. The final objective was to integrate our chosen technologies with our Joint Probability Density Function (Joint PDF), Wave Number Analysis, and

  7. EEGLAB, SIFT, NFT, BCILAB, and ERICA: New Tools for Advanced EEG Processing

    PubMed Central

    Delorme, Arnaud; Mullen, Tim; Kothe, Christian; Akalin Acar, Zeynep; Bigdely-Shamlo, Nima; Vankov, Andrey; Makeig, Scott

    2011-01-01

    We describe a set of complementary EEG data collection and processing tools recently developed at the Swartz Center for Computational Neuroscience (SCCN) that connect to and extend the EEGLAB software environment, a freely available and readily extensible processing environment running under Matlab. The new tools include (1) a new and flexible EEGLAB STUDY design facility for framing and performing statistical analyses on data from multiple subjects; (2) a neuroelectromagnetic forward head modeling toolbox (NFT) for building realistic electrical head models from available data; (3) a source information flow toolbox (SIFT) for modeling ongoing or event-related effective connectivity between cortical areas; (4) a BCILAB toolbox for building online brain-computer interface (BCI) models from available data, and (5) an experimental real-time interactive control and analysis (ERICA) environment for real-time production and coordination of interactive, multimodal experiments. PMID:21687590

  8. Anvil Forecast Tool in the Advanced Weather Interactive Processing System, Phase II

    NASA Technical Reports Server (NTRS)

    Barrett, Joe H., III

    2008-01-01

    Meteorologists from the 45th Weather Squadron (45 WS) and Spaceflight Meteorology Group have identified anvil forecasting as one of their most challenging tasks when predicting the probability of violations of the Lightning Launch Commit Criteria and Space Light Rules. As a result, the Applied Meteorology Unit (AMU) created a graphical overlay tool for the Meteorological Interactive Data Display Systems (MIDDS) to indicate the threat of thunderstorm anvil clouds, using either observed or model forecast winds as input.

  9. ADVANCEMENT OF NUCLEIC ACID-BASED TOOLS FOR MONITORING IN SITU REDUCTIVE DECHLORINATION

    SciTech Connect

    Vangelas, K; ELIZABETH EDWARDS, E; FRANK LOFFLER, F; Brian02 Looney, B

    2006-11-17

    Regulatory protocols generally recognize that destructive processes are the most effective mechanisms that support natural attenuation of chlorinated solvents. In many cases, these destructive processes will be biological processes and, for chlorinated compounds, will often be reductive processes that occur under anaerobic conditions. The existing EPA guidance (EPA, 1998) provides a list of parameters that provide indirect evidence of reductive dechlorination processes. In an effort to gather direct evidence of these processes, scientists have identified key microorganisms and are currently developing tools to measure the abundance and activity of these organisms in subsurface systems. Drs. Edwards and Luffler are two recognized leaders in this field. The research described herein continues their development efforts to provide a suite of tools to enable direct measures of biological processes related to the reductive dechlorination of TCE and PCE. This study investigated the strengths and weaknesses of the 16S rRNA gene-based approach to characterizing the natural attenuation capabilities in samples. The results suggested that an approach based solely on 16S rRNA may not provide sufficient information to document the natural attenuation capabilities in a system because it does not distinguish between strains of organisms that have different biodegradation capabilities. The results of the investigations provided evidence that tools focusing on relevant enzymes for functionally desired characteristics may be useful adjuncts to the 16SrRNA methods.

  10. A Multi-layer, Data-driven Advanced Reasoning Tool for Intelligent Data Mining and Analysis for Smart Grids

    SciTech Connect

    Lu, Ning; Du, Pengwei; Greitzer, Frank L.; Guo, Xinxin; Hohimer, Ryan E.; Pomiak, Yekaterina G.

    2012-12-31

    This paper presents the multi-layer, data-driven advanced reasoning tool (M-DART), a proof-of-principle decision support tool for improved power system operation. M-DART will cross-correlate and examine different data sources to assess anomalies, infer root causes, and anneal data into actionable information. By performing higher-level reasoning “triage” of diverse data sources, M-DART focuses on early detection of emerging power system events and identifies highest priority actions for the human decision maker. M-DART represents a significant advancement over today’s grid monitoring technologies that apply offline analyses to derive model-based guidelines for online real-time operations and use isolated data processing mechanisms focusing on individual data domains. The development of the M-DART will bridge these gaps by reasoning about results obtained from multiple data sources that are enabled by the smart grid infrastructure. This hybrid approach integrates a knowledge base that is trained offline but tuned online to capture model-based relationships while revealing complex causal relationships among data from different domains.

  11. Performance analysis and optimization of an advanced pharmaceutical wastewater treatment plant through a visual basic software tool (PWWT.VB).

    PubMed

    Pal, Parimal; Thakura, Ritwik; Chakrabortty, Sankha

    2016-05-01

    A user-friendly, menu-driven simulation software tool has been developed for the first time to optimize and analyze the system performance of an advanced continuous membrane-integrated pharmaceutical wastewater treatment plant. The software allows pre-analysis and manipulation of input data which helps in optimization and shows the software performance visually on a graphical platform. Moreover, the software helps the user to "visualize" the effects of the operating parameters through its model-predicted output profiles. The software is based on a dynamic mathematical model, developed for a systematically integrated forward osmosis-nanofiltration process for removal of toxic organic compounds from pharmaceutical wastewater. The model-predicted values have been observed to corroborate well with the extensive experimental investigations which were found to be consistent under varying operating conditions like operating pressure, operating flow rate, and draw solute concentration. Low values of the relative error (RE = 0.09) and high values of Willmott-d-index (d will = 0.981) reflected a high degree of accuracy and reliability of the software. This software is likely to be a very efficient tool for system design or simulation of an advanced membrane-integrated treatment plant for hazardous wastewater.

  12. CONFERENCE NOTE: International Workshop on Advanced Mathematical Tools in Metrology, Villa Gualino, Torino, Italy, 20 22 October 1993

    NASA Astrophysics Data System (ADS)

    1993-01-01

    Preliminary Programme The three-day programme features approximately twenty-five invited contributions. Participants may present a poster on the topic "Applications for Industrial Measurements", concerning applied mathematics, software development and computer-based measurements. 20 October Two plenary talks on mathematical methods and metrological applications "Numerical Methods and Modelling" Partial differential equations and integral equations Methods of identification and validation Algorithms for approximation Geometrical shape determination of industrial solids Round Table 21 October "Data Analysis" Spectral analysis and wavelets Calibration of precision instrumentation Comparison measurement of standards Statistical methods in metrology Robust estimation and outliers Applications of the bootstrap method Round Table 22 October (in cooperation with SIMAI and ASP) "Applications for Industrial Measurements" Data acquisition Measurement software, standard computational modules and their validation Round Table Industrial presentations Discussion of poster presentations Conclusions Lecturers Mathematicians from the international metrological community; mathematicians from Italian universities (Politecnico of Torino, Milano, Università di Genova, Milano, Padova, Roma, Trento); scientists and mathematicians from national standards institutes and the Italian National Research Council. The workshop will be of interest to people in universities, research centres and industry who are involved in measurement and need advanced mathematical tools to solve their problems, and to those who work in the development of these mathematical tools. Metrology is concerned with measurement at the highest level of precision. Advances in metrology depend on many factors: improvements in scientific and technical knowledge, instrumentation quality, better use of advanced mathematical tools and the development of new tools. In some countries, metrological institutions have a tradition of

  13. Pantograph catenary dynamic optimisation based on advanced multibody and finite element co-simulation tools

    NASA Astrophysics Data System (ADS)

    Massat, Jean-Pierre; Laurent, Christophe; Bianchi, Jean-Philippe; Balmès, Etienne

    2014-05-01

    This paper presents recent developments undertaken by SNCF Innovation & Research Department on numerical modelling of pantograph catenary interaction. It aims at describing an efficient co-simulation process between finite element (FE) and multibody (MB) modelling methods. FE catenary models are coupled with a full flexible MB representation with pneumatic actuation of pantograph. These advanced functionalities allow new kind of numerical analyses such as dynamic improvements based on innovative pneumatic suspensions or assessment of crash risks crossing areas that demonstrate the powerful capabilities of this computing approach.

  14. The Advanced Light Source: A new tool for research in atomic and molecular physics

    NASA Astrophysics Data System (ADS)

    Schlachter, F.; Robinson, A.

    1991-04-01

    The Advanced Light Source at the Lawrence Berkeley Laboratory will be the world's brightest synchrotron radiation source in the extreme ultraviolet and soft x-ray regions of the spectrum when it begins operation in 1993. It will be available as a national user facility to researchers in a broad range of disciplines, including materials science, atomic and molecular physics, chemistry, biology, imaging, and technology. The high brightness of the ALS will be particularly well suited to high-resolution studies of tenuous targets, such as excited atoms, ions, and clusters.

  15. Advanced techniques in IR thermography as a tool for the pest management professional

    NASA Astrophysics Data System (ADS)

    Grossman, Jon L.

    2006-04-01

    Within the past five years, the Pest Management industry has become aware that IR thermography can aid in the detection of pest infestations and locate other conditions that are within the purview of the industry. This paper will review the applications that can be utilized by the pest management professional and discuss the advanced techniques that may be required in conjunction with thermal imaging to locate insect and other pest infestations, moisture within structures, the verification of data and the special challenges associated with the inspection process.

  16. Advancing of Russian ChemBioGrid by bringing Data Management tools into collaborative environment.

    PubMed

    Zhuchkov, Alexey; Tverdokhlebov, Nikolay; Kravchenko, Alexander

    2006-01-01

    Virtual organizations of researchers need effective tools to work collaboratively with huge sets of heterogeneous data distributed over HealthGrid. This paper describes a mechanism of supporting Digital Libraries in High-Performance Computing environment based on Grid technology. The proposed approach provides abilities to assemble heterogeneous data from distributed sources into integrated virtual collections by using OGSA-DAI. The core of the conception is a Repository of Meta-Descriptions that are sets of metadata which define personal and collaborative virtual collections on base of virtualized information resources. The Repository is kept in a native XML-database Sedna and is maintained by Grid Data Services.

  17. NASA Advanced Concepts Office, Earth-To-Orbit Team Design Process and Tools

    NASA Technical Reports Server (NTRS)

    Waters, Eric D.; Garcia, Jessica; Beers, Benjamin; Philips, Alan; Holt, James B.; Threet, Grady E., Jr.

    2013-01-01

    The Earth to Orbit (ETO) Team of the Advanced Concepts Office (ACO) at NASA Marshal Space Flight Center (MSFC) is considered the preeminent group to go to for prephase A and phase A concept definition. The ACO team has been at the forefront of a multitude of launch vehicle studies determining the future direction of the Agency as a whole due, in part, to their rapid turnaround time in analyzing concepts and their ability to cover broad trade spaces of vehicles in that limited timeframe. Each completed vehicle concept includes a full mass breakdown of each vehicle to tertiary subsystem components, along with a vehicle trajectory analysis to determine optimized payload delivery to specified orbital parameters, flight environments, and delta v capability. Additionally, a structural analysis of the vehicle based on material properties and geometries is performed as well as an analysis to determine the flight loads based on the trajectory outputs. As mentioned, the ACO Earth to Orbit Team prides themselves on their rapid turnaround time and often need to fulfill customer requests within limited schedule or little advanced notice. Due to working in this fast paced environment, the ETO team has developed some finely honed skills and methods to maximize the delivery capability to meet their customer needs. This paper will describe the interfaces between the 3 primary disciplines used in the design process; weights and sizing, trajectory, and structural analysis, as well as the approach each discipline employs to streamline their particular piece of the design process.

  18. Quartermaster Reach Restoration Project

    EPA Pesticide Factsheets

    Information about the SFBWQP Quartermaster Reach Restoration Project, part of an EPA competitive grant program to improve SF Bay water quality focused on restoring impaired waters and enhancing aquatic resources.

  19. Global reach and engagement

    NASA Astrophysics Data System (ADS)

    2016-09-01

    Popular culture reflects both the interests of and the issues affecting the general public. As concerns regarding climate change and its impacts grow, is it permeating into popular culture and reaching that global audience?

  20. Emerging tools for continuous nutrient monitoring networks: Sensors advancing science and water resources protection

    USGS Publications Warehouse

    Pellerin, Brian; Stauffer, Beth A; Young, Dwane A; Sullivan, Daniel J.; Bricker, Suzanne B.; Walbridge, Mark R; Clyde, Gerard A; Shaw, Denice M

    2016-01-01

    Sensors and enabling technologies are becoming increasingly important tools for water quality monitoring and associated water resource management decisions. In particular, nutrient sensors are of interest because of the well-known adverse effects of nutrient enrichment on coastal hypoxia, harmful algal blooms, and impacts to human health. Accurate and timely information on nutrient concentrations and loads is integral to strategies designed to minimize risk to humans and manage the underlying drivers of water quality impairment. Using nitrate sensors as an example, we highlight the types of applications in freshwater and coastal environments that are likely to benefit from continuous, real-time nutrient data. The concurrent emergence of new tools to integrate, manage and share large data sets is critical to the successful use of nutrient sensors and has made it possible for the field of continuous nutrient monitoring to rapidly move forward. We highlight several near-term opportunities for Federal agencies, as well as the broader scientific and management community, that will help accelerate sensor development, build and leverage sites within a national network, and develop open data standards and data management protocols that are key to realizing the benefits of a large-scale, integrated monitoring network. Investing in these opportunities will provide new information to guide management and policies designed to protect and restore our nation’s water resources.

  1. GenSAA: A tool for advancing satellite monitoring with graphical expert systems

    NASA Technical Reports Server (NTRS)

    Hughes, Peter M.; Luczak, Edward C.

    1993-01-01

    During numerous contacts with a satellite each day, spacecraft analysts must closely monitor real time data for combinations of telemetry parameter values, trends, and other indications that may signify a problem or failure. As satellites become more complex and the number of data items increases, this task is becoming increasingly difficult for humans to perform at acceptable performance levels. At the NASA Goddard Space Flight Center, fault-isolation expert systems have been developed to support data monitoring and fault detection tasks in satellite control centers. Based on the lessons learned during these initial efforts in expert system automation, a new domain-specific expert system development tool named the Generic Spacecraft Analyst Assistant (GenSAA) is being developed to facilitate the rapid development and reuse of real-time expert systems to serve as fault-isolation assistants for spacecraft analysts. Although initially domain-specific in nature, this powerful tool will support the development of highly graphical expert systems for data monitoring purposes throughout the space and commercial industry.

  2. Recent advances in developing molecular tools for targeted genome engineering of mammalian cells.

    PubMed

    Lim, Kwang-il

    2015-01-01

    Various biological molecules naturally existing in diversified species including fungi, bacteria, and bacteriophage have functionalities for DNA binding and processing. The biological molecules have been recently actively engineered for use in customized genome editing of mammalian cells as the molecule-encoding DNA sequence information and the underlying mechanisms how the molecules work are unveiled. Excitingly, multiple novel methods based on the newly constructed artificial molecular tools have enabled modifications of specific endogenous genetic elements in the genome context at efficiencies that are much higher than that of the conventional homologous recombination based methods. This minireview introduces the most recently spotlighted molecular genome engineering tools with their key features and ongoing modifications for better performance. Such ongoing efforts have mainly focused on the removal of the inherent DNA sequence recognition rigidity from the original molecular platforms, the addition of newly tailored targeting functions into the engineered molecules, and the enhancement of their targeting specificity. Effective targeted genome engineering of mammalian cells will enable not only sophisticated genetic studies in the context of the genome, but also widely-applicable universal therapeutics based on the pinpointing and correction of the disease-causing genetic elements within the genome in the near future.

  3. Development of tools for safety analysis of control software in advanced reactors

    SciTech Connect

    Guarro, S.; Yau, M.; Motamed, M.

    1996-04-01

    Software based control systems have gained a pervasive presence in a wide variety of applications, including nuclear power plant control and protection systems which are within the oversight and licensing responsibility of the US Nuclear Regulatory Commission. While the cost effectiveness and flexibility of software based plant process control is widely recognized, it is very difficult to achieve and prove high levels of demonstrated dependability and safety assurance for the functions performed by process control software, due to the very flexibility and potential complexity of the software itself. The development of tools to model, analyze and test software design and implementations in the context of the system that the software is designed to control can greatly assist the task of providing higher levels of assurance than those obtainable by software testing alone. This report presents and discusses the development of the Dynamic Flowgraph Methodology (DFM) and its application in the dependability and assurance analysis of software-based control systems. The features of the methodology and full-scale examples of application to both generic process and nuclear power plant control systems are presented and discussed in detail. The features of a workstation software tool developed to assist users in the application of DFM are also described.

  4. Neuron-Miner: An Advanced Tool for Morphological Search and Retrieval in Neuroscientific Image Databases.

    PubMed

    Conjeti, Sailesh; Mesbah, Sepideh; Negahdar, Mohammadreza; Rautenberg, Philipp L; Zhang, Shaoting; Navab, Nassir; Katouzian, Amin

    2016-10-01

    The steadily growing amounts of digital neuroscientific data demands for a reliable, systematic, and computationally effective retrieval algorithm. In this paper, we present Neuron-Miner, which is a tool for fast and accurate reference-based retrieval within neuron image databases. The proposed algorithm is established upon hashing (search and retrieval) technique by employing multiple unsupervised random trees, collectively called as Hashing Forests (HF). The HF are trained to parse the neuromorphological space hierarchically and preserve the inherent neuron neighborhoods while encoding with compact binary codewords. We further introduce the inverse-coding formulation within HF to effectively mitigate pairwise neuron similarity comparisons, thus allowing scalability to massive databases with little additional time overhead. The proposed hashing tool has superior approximation of the true neuromorphological neighborhood with better retrieval and ranking performance in comparison to existing generalized hashing methods. This is exhaustively validated by quantifying the results over 31266 neuron reconstructions from Neuromorpho.org dataset curated from 147 different archives. We envisage that finding and ranking similar neurons through reference-based querying via Neuron Miner would assist neuroscientists in objectively understanding the relationship between neuronal structure and function for applications in comparative anatomy or diagnosis.

  5. Using explanatory crop models to develop simple tools for Advanced Life Support system studies

    NASA Technical Reports Server (NTRS)

    Cavazzoni, J.

    2004-01-01

    System-level analyses for Advanced Life Support require mathematical models for various processes, such as for biomass production and waste management, which would ideally be integrated into overall system models. Explanatory models (also referred to as mechanistic or process models) would provide the basis for a more robust system model, as these would be based on an understanding of specific processes. However, implementing such models at the system level may not always be practicable because of their complexity. For the area of biomass production, explanatory models were used to generate parameters and multivariable polynomial equations for basic models that are suitable for estimating the direction and magnitude of daily changes in canopy gas-exchange, harvest index, and production scheduling for both nominal and off-nominal growing conditions. c2004 COSPAR. Published by Elsevier Ltd. All rights reserved.

  6. The advanced light source — a new tool for research in atomic physics

    NASA Astrophysics Data System (ADS)

    Schlachter, A. S.

    1991-03-01

    The Advanced Light Source, a third-generation national synchrotron-radiation facility now under construction at the Lawrence Berkeley Laboratory in Berkeley, California, is scheduled to begin serving qualified users across a broad spectrum of research areas in the spring of 1993. Undulators will generate high-brightness, partially coherent, plane polarized, soft x-ray and ultraviolet (XUV) radiation from below 10 eV to above 2 keV. Wigglers and bend magnets will generate high fluxes of x-rays to photon energies above 10 keV. The ALS will have an extensive research program in which XUV radiation is used to study matter in all its varied gaseous, liquid, and solid forms.

  7. The advanced light source: A new tool for research in atomic physics

    NASA Astrophysics Data System (ADS)

    Schlachter, A. S.

    1990-09-01

    The Advanced Light Source, a third-generation national synchrotron-radiation facility now under construction at the Lawrence Berkeley Laboratory in Berkeley, California, is scheduled to begin serving qualified users across a broad spectrum of research areas in the spring of 1993. Undulators will generate high-brightness, partially coherent, plane polarized, soft-x-ray and ultraviolet (XUV) radiation from below 10 eV to above 2 keV. Wigglers and bend magnets will generate high fluxes of x-rays to photon energies above 10 keV. The ALS will have an extensive research program in which XUV radiation is used to study matter in all its varied gaseous, liquid, and solid forms.

  8. Virtual charge state separator as an advanced tool coupling measurements and simulations

    NASA Astrophysics Data System (ADS)

    Yaramyshev, S.; Vormann, H.; Adonin, A.; Barth, W.; Dahl, L.; Gerhard, P.; Groening, L.; Hollinger, R.; Maier, M.; Mickat, S.; Orzhekhovskaya, A.

    2015-05-01

    A new low energy beam transport for a multicharge uranium beam will be built at the GSI High Current Injector (HSI). All uranium charge states coming from the new ion source will be injected into GSI heavy ion high current HSI Radio Frequency Quadrupole (RFQ), but only the design ions U4 + will be accelerated to the final RFQ energy. A detailed knowledge about injected beam current and emittance for pure design U4 + ions is necessary for a proper beam line design commissioning and operation, while measurements are possible only for a full beam including all charge states. Detailed measurements of the beam current and emittance are performed behind the first quadrupole triplet of the beam line. A dedicated algorithm, based on a combination of measurements and the results of advanced beam dynamics simulations, provides for an extraction of beam current and emittance values for only the U4 + component of the beam. The proposed methods and obtained results are presented.

  9. Microfluidic chips with multi-junctions: an advanced tool in recovering proteins from inclusion bodies.

    PubMed

    Yamaguchi, Hiroshi; Miyazaki, Masaya

    2015-01-01

    Active recombinant proteins are used for studying the biological functions of genes and for the development of therapeutic drugs. Overexpression of recombinant proteins in bacteria often results in the formation of inclusion bodies, which are protein aggregates with non-native conformations. Protein refolding is an important process for obtaining active recombinant proteins from inclusion bodies. However, the conventional refolding method of dialysis or dilution is time-consuming and recovered active protein yields are often low, and a cumbersome trial-and-error process is required to achieve success. To circumvent these difficulties, we used controllable diffusion through laminar flow in microchannels to regulate the denaturant concentration. This method largely aims at reducing protein aggregation during the refolding procedure. This Commentary introduces the principles of the protein refolding method using microfluidic chips and the advantage of our results as a tool for rapid and efficient recovery of active recombinant proteins from inclusion bodies.

  10. A software tool for advanced MRgFUS prostate therapy planning and follow up

    NASA Astrophysics Data System (ADS)

    van Straaten, Dörte; Hoogenboom, Martijn; van Amerongen, Martinus J.; Weiler, Florian; Issawi, Jumana Al; Günther, Matthias; Fütterer, Jurgen; Jenne, Jürgen W.

    2017-03-01

    US guided HIFU/FUS ablation for the therapy of prostate cancer is a clinical established method, while MR guided HIFU/FUS applications for prostate recently started clinical evaluation. Even if MRI examination is an excellent diagnostic tool for prostate cancer, it is a time consuming procedure and not practicable within an MRgFUS therapy session. The aim of our ongoing work is to develop software to support therapy planning and post-therapy follow-up for MRgFUS on localized prostate cancer, based on multi-parametric MR protocols. The clinical workflow of diagnosis, therapy and follow-up of MR guided FUS on prostate cancer was deeply analyzed. Based on this, the image processing workflow was designed and all necessary components, e.g. GUI, viewer, registration tools etc. were defined and implemented. The software bases on MeVisLab with several implemented C++ modules for the image processing tasks. The developed software, called LTC (Local Therapy Control) will register and visualize automatically all images (T1w, T2w, DWI etc.) and ADC or perfusion maps gained from the diagnostic MRI session. This maximum of diagnostic information helps to segment all necessary ROIs, e.g. the tumor, for therapy planning. Final therapy planning will be performed based on these segmentation data in the following MRgFUS therapy session. In addition, the developed software should help to evaluate the therapy success, by synchronization and display of pre-therapeutic, therapy and follow-up image data including the therapy plan and thermal dose information. In this ongoing project, the first stand-alone prototype was completed and will be clinically evaluated.

  11. Advancing spaceborne tools for the characterization of planetary ionospheres and circumstellar environments

    NASA Astrophysics Data System (ADS)

    Douglas, Ewan Streets

    This work explores remote sensing of planetary atmospheres and their circumstellar surroundings. The terrestrial ionosphere is a highly variable space plasma embedded in the thermosphere. Generated by solar radiation and predominantly composed of oxygen ions at high altitudes, the ionosphere is dynamically and chemically coupled to the neutral atmosphere. Variations in ionospheric plasma density impact radio astronomy and communications. Inverting observations of 83.4 nm photons resonantly scattered by singly ionized oxygen holds promise for remotely sensing the ionospheric plasma density. This hypothesis was tested by comparing 83.4 nm limb profiles recorded by the Remote Atmospheric and Ionospheric Detection System aboard the International Space Station to a forward model driven by coincident plasma densities measured independently via ground-based incoherent scatter radar. A comparison study of two separate radar overflights with different limb profile morphologies found agreement between the forward model and measured limb profiles. A new implementation of Chapman parameter retrieval via Markov chain Monte Carlo techniques quantifies the precision of the plasma densities inferred from 83.4 nm emission profiles. This first study demonstrates the utility of 83.4 nm emission for ionospheric remote sensing. Future visible and ultraviolet spectroscopy will characterize the composition of exoplanet atmospheres; therefore, the second study advances technologies for the direct imaging and spectroscopy of exoplanets. Such spectroscopy requires the development of new technologies to separate relatively dim exoplanet light from parent star light. High-contrast observations at short wavelengths require spaceborne telescopes to circumvent atmospheric aberrations. The Planet Imaging Concept Testbed Using a Rocket Experiment (PICTURE) team designed a suborbital sounding rocket payload to demonstrate visible light high-contrast imaging with a visible nulling coronagraph

  12. The advanced light source at Lawrence Berkeley laboratory: a new tool for research in atomic physics

    NASA Astrophysics Data System (ADS)

    Schlachter, Alfred S.; Robinson, Arthur L.

    1991-04-01

    The Advanced Light Source, a third-generation national synchrotron-radiation facility now under construction at the Lawrence Berkeley Laboratory, is scheduled to begin serving qualified users across a broad spectrum of research areas in the spring of 1993. Based on a low-emittance electron storage ring optimized to operate at 1.5 GeV, the ALS will have 10 long straight sections available for insertion devices (undulators and wigglers) and 24 high-quality bend-magnet ports. The short pulse width (30-50 ps) will be ideal for time-resolved measurements. Undulators will generate high-brightness partially coherent soft X-ray and ultraviolet (XUV) radiation from below 10 eV to above 2 keV; this radiation is plane polarized. Wigglers and bend magnets will extend the spectrum by generating high fluxes of X-rays to photon energies above 10 keV. The ALS will have an extensive research program in which XUV radiation is used to study matter in all its varied gaseous, liquid, and solid forms. The high brightness will open new areas of research in the materials sciences, such as spatially resolved spectroscopy (spectromicroscopy), and in biology, such as X-ray microscopy with element-specific sensitivity; the high flux will allow measurements in atomic physics and chemistry to be made with tenuous gas-phase targets. Technological applications could include lithography and nano-fabrication.

  13. Advances in developing molecular-diagnostic tools for strongyloid nematodes of equids: fundamental and applied implications.

    PubMed

    Gasser, Robin B; Hung, Guo-Chiuan; Chilton, Neil B; Beveridge, Ian

    2004-02-01

    Infections of equids with parasitic nematodes of the order Strongylida (subfamilies Strongylinae and Cyathostominae) are of major veterinary importance. In last decades, the widespread use of drugs against these parasites has led to problems of resistance within the Cyathostominae, and to an increase in their prevalence and intensity of infection. Novel control strategies, based on improved knowledge of parasite biology and epidemiology, have thus become important. However, there are substantial limitations in the understanding of fundamental biological and systematic aspects of these parasites, which have been due largely to limitations in their specific identification and diagnosis using traditional, morphological approaches. Recently, there has been progress in the development of DNA-based approaches for the specific identification of strongyloids of equids for systematic studies and disease diagnosis. The present article briefly reviews information on the classification, biology, pathogenesis, epidemiology of equine strongyloids and the diagnosis of infections, highlights knowledge gaps in these areas, describes recent advances in the use of molecular techniques for the genetic characterisation, specific identification and differentiation of strongyloids of equids as a basis for fundamental investigations of the systematics, population biology and ecology.

  14. Propulsion Simulations Using Advanced Turbulence Models with the Unstructured Grid CFD Tool, TetrUSS

    NASA Technical Reports Server (NTRS)

    Abdol-Hamid, Khaled S.; Frink, Neal T.; Deere, Karen A.; Pandya, Mohangna J.

    2004-01-01

    A computational investigation has been completed to assess the capability of TetrUSS for exhaust nozzle flows. Three configurations were chosen for this study (1) an axisymmetric supersonic jet, (2) a transonic axisymmetric boattail with solid sting operated at different Reynolds number and Mach number, and (3) an isolated non-axisymmetric nacelle with a supersonic cruise nozzle. These configurations were chosen because existing experimental data provided a means for measuring the ability of TetrUSS for simulating complex nozzle flows. The main objective of this paper is to validate the implementation of advanced two-equation turbulence models in the unstructured-grid CFD code USM3D for propulsion flow cases. USM3D is the flow solver of the TetrUSS system. Three different turbulence models, namely, Menter Shear Stress Transport (SST), basic k epsilon, and the Spalart-Allmaras (SA) are used in the present study. The results are generally in agreement with other implementations of these models in structured-grid CFD codes. Results indicate that USM3D provides accurate simulations for complex aerodynamic configurations with propulsion integration.

  15. Terahertz pulsed imaging as an advanced characterisation tool for film coatings--a review.

    PubMed

    Haaser, Miriam; Gordon, Keith C; Strachan, Clare J; Rades, Thomas

    2013-12-05

    Solid dosage forms are the pharmaceutical drug delivery systems of choice for oral drug delivery. These solid dosage forms are often coated to modify the physico-chemical properties of the active pharmaceutical ingredients (APIs), in particular to alter release kinetics. Since the product performance of coated dosage forms is a function of their critical coating attributes, including coating thickness, uniformity, and density, more advanced quality control techniques than weight gain are required. A recently introduced non-destructive method to quantitatively characterise coating quality is terahertz pulsed imaging (TPI). The ability of terahertz radiation to penetrate many pharmaceutical materials enables structural features of coated solid dosage forms to be probed at depth, which is not readily achievable with other established imaging techniques, e.g. near-infrared (NIR) and Raman spectroscopy. In this review TPI is introduced and various applications of the technique in pharmaceutical coating analysis are discussed. These include evaluation of coating thickness, uniformity, surface morphology, density, defects and buried structures as well as correlation between TPI measurements and drug release performance, coating process monitoring and scale up. Furthermore, challenges and limitations of the technique are discussed.

  16. Advanced Online Survival Analysis Tool for Predictive Modelling in Clinical Data Science.

    PubMed

    Montes-Torres, Julio; Subirats, José Luis; Ribelles, Nuria; Urda, Daniel; Franco, Leonardo; Alba, Emilio; Jerez, José Manuel

    2016-01-01

    One of the prevailing applications of machine learning is the use of predictive modelling in clinical survival analysis. In this work, we present our view of the current situation of computer tools for survival analysis, stressing the need of transferring the latest results in the field of machine learning to biomedical researchers. We propose a web based software for survival analysis called OSA (Online Survival Analysis), which has been developed as an open access and user friendly option to obtain discrete time, predictive survival models at individual level using machine learning techniques, and to perform standard survival analysis. OSA employs an Artificial Neural Network (ANN) based method to produce the predictive survival models. Additionally, the software can easily generate survival and hazard curves with multiple options to personalise the plots, obtain contingency tables from the uploaded data to perform different tests, and fit a Cox regression model from a number of predictor variables. In the Materials and Methods section, we depict the general architecture of the application and introduce the mathematical background of each of the implemented methods. The study concludes with examples of use showing the results obtained with public datasets.

  17. Advanced Online Survival Analysis Tool for Predictive Modelling in Clinical Data Science

    PubMed Central

    Montes-Torres, Julio; Subirats, José Luis; Ribelles, Nuria; Urda, Daniel; Franco, Leonardo; Alba, Emilio; Jerez, José Manuel

    2016-01-01

    One of the prevailing applications of machine learning is the use of predictive modelling in clinical survival analysis. In this work, we present our view of the current situation of computer tools for survival analysis, stressing the need of transferring the latest results in the field of machine learning to biomedical researchers. We propose a web based software for survival analysis called OSA (Online Survival Analysis), which has been developed as an open access and user friendly option to obtain discrete time, predictive survival models at individual level using machine learning techniques, and to perform standard survival analysis. OSA employs an Artificial Neural Network (ANN) based method to produce the predictive survival models. Additionally, the software can easily generate survival and hazard curves with multiple options to personalise the plots, obtain contingency tables from the uploaded data to perform different tests, and fit a Cox regression model from a number of predictor variables. In the Materials and Methods section, we depict the general architecture of the application and introduce the mathematical background of each of the implemented methods. The study concludes with examples of use showing the results obtained with public datasets. PMID:27532883

  18. A new tool to give hospitalists feedback to improve interprofessional teamwork and advance patient care.

    PubMed

    Chesluk, Benjamin J; Bernabeo, Elizabeth; Hess, Brian; Lynn, Lorna A; Reddy, Siddharta; Holmboe, Eric S

    2012-11-01

    Teamwork is a vital skill for health care professionals, but the fragmented systems within which they work frequently do not recognize or support good teamwork. The American Board of Internal Medicine has developed and is testing the Teamwork Effectiveness Assessment Module (TEAM), a tool for physicians to evaluate how they perform as part of an interprofessional patient care team. The assessment provides hospitalist physicians with feedback data drawn from their own work of caring for patients, in a way that is intended to support immediate, concrete change efforts to improve the quality of patient care. Our approach demonstrates the value of looking at teamwork in the real world of health care-that is, as it occurs in the actual contexts in which providers work together to care for patients. The assessment of individual physicians' teamwork competencies may play a role in the larger effort to bring disparate health professions together in a system that supports and rewards a team approach in hope of improving patient care.

  19. Advanced semi-active engine and transmission mounts: tools for modelling, analysis, design, and tuning

    NASA Astrophysics Data System (ADS)

    Farjoud, Alireza; Taylor, Russell; Schumann, Eric; Schlangen, Timothy

    2014-02-01

    This paper is focused on modelling, design, and testing of semi-active magneto-rheological (MR) engine and transmission mounts used in the automotive industry. The purpose is to develop a complete analysis, synthesis, design, and tuning tool that reduces the need for expensive and time-consuming laboratory and field tests. A detailed mathematical model of such devices is developed using multi-physics modelling techniques for physical systems with various energy domains. The model includes all major features of an MR mount including fluid dynamics, fluid track, elastic components, decoupler, rate-dip, gas-charged chamber, MR fluid rheology, magnetic circuit, electronic driver, and control algorithm. Conventional passive hydraulic mounts can also be studied using the same mathematical model. The model is validated using standard experimental procedures. It is used for design and parametric study of mounts; effects of various geometric and material parameters on dynamic response of mounts can be studied. Additionally, this model can be used to test various control strategies to obtain best vibration isolation performance by tuning control parameters. Another benefit of this work is that nonlinear interactions between sub-components of the mount can be observed and investigated. This is not possible by using simplified linear models currently available.

  20. Reaching for the Stars

    ERIC Educational Resources Information Center

    Terry, Dorothy Givens

    2012-01-01

    Dr. Mae Jemison is the world's first woman astronaut of color who continues to reach for the stars. Jemison was recently successful in leading a team that has secured a $500,000 federal grant to make interstellar space travel a reality. The Dorothy Jemison Foundation for Excellence (named after Jemison's mother) was selected in June by the Defense…

  1. Reaching for the Stars.

    ERIC Educational Resources Information Center

    Roper-Davis, Sharon

    1999-01-01

    Describes "Reaching for the Stars," a program which develops teaming and mentoring skills in senior physics students. Phase 1 requires student pairs to design a rocket; Phase 2 pairs seniors with gifted second graders who build the rocket from written instructions; and in Phase 3, pairs of seniors create a children's storybook explaining…

  2. REACH. Air Conditioning Units.

    ERIC Educational Resources Information Center

    Garrison, Joe; And Others

    As a part of the REACH (Refrigeration, Electro-Mechanical, Air-Conditioning, Heating) electromechanical cluster, this student manual contains individualized instructional units in the area of air conditioning. The instructional units focus on air conditioning fundamentals, window air conditioning, system and installation, troubleshooting and…

  3. REACH. Major Appliance.

    ERIC Educational Resources Information Center

    English, Charles; And Others

    As a part of the REACH (Refrigeration, Electro-Mechanical, Air-Conditioning, Heating) electromechanical cluster, this student manual contains individualized instructional units in the area of major appliances. The instructional units focus on installation of appliances, troubleshooting washing machines, troubleshooting electric dryers,…

  4. REACH. Heating Units.

    ERIC Educational Resources Information Center

    Stanfield, Carter; And Others

    As a part of the REACH (Refrigeration, Electro-Mechanical, Air-Conditioning, Heating) electromechanical cluster, this student manual contains individualized units in the area of heating. The instructional units focus on electric heating systems, gas heating systems, and oil burning systems. Each unit follows a typical format that includes a unit…

  5. REACH. Refrigeration Units.

    ERIC Educational Resources Information Center

    Snow, Rufus; And Others

    As a part of the REACH (Refrigeration, Electro-Mechanical, Air-Conditioning, Heating) electromechanical cluster, this student manual contains individualized instructional units in the area of refrigeration. The instructional units focus on refrigeration fundamentals, tubing and pipe, refrigerants, troubleshooting, window air conditioning, and…

  6. Randomized Controlled Trial of a Video Decision Support Tool for Cardiopulmonary Resuscitation Decision Making in Advanced Cancer

    PubMed Central

    Volandes, Angelo E.; Paasche-Orlow, Michael K.; Mitchell, Susan L.; El-Jawahri, Areej; Davis, Aretha Delight; Barry, Michael J.; Hartshorn, Kevan L.; Jackson, Vicki Ann; Gillick, Muriel R.; Walker-Corkery, Elizabeth S.; Chang, Yuchiao; López, Lenny; Kemeny, Margaret; Bulone, Linda; Mann, Eileen; Misra, Sumi; Peachey, Matt; Abbo, Elmer D.; Eichler, April F.; Epstein, Andrew S.; Noy, Ariela; Levin, Tomer T.; Temel, Jennifer S.

    2013-01-01

    Purpose Decision making regarding cardiopulmonary resuscitation (CPR) is challenging. This study examined the effect of a video decision support tool on CPR preferences among patients with advanced cancer. Patients and Methods We performed a randomized controlled trial of 150 patients with advanced cancer from four oncology centers. Participants in the control arm (n = 80) listened to a verbal narrative describing CPR and the likelihood of successful resuscitation. Participants in the intervention arm (n = 70) listened to the identical narrative and viewed a 3-minute video depicting a patient on a ventilator and CPR being performed on a simulated patient. The primary outcome was participants' preference for or against CPR measured immediately after exposure to either modality. Secondary outcomes were participants' knowledge of CPR (score range of 0 to 4, with higher score indicating more knowledge) and comfort with video. Results The mean age of participants was 62 years (standard deviation, 11 years); 49% were women, 44% were African American or Latino, and 47% had lung or colon cancer. After the verbal narrative, in the control arm, 38 participants (48%) wanted CPR, 41 (51%) wanted no CPR, and one (1%) was uncertain. In contrast, in the intervention arm, 14 participants (20%) wanted CPR, 55 (79%) wanted no CPR, and 1 (1%) was uncertain (unadjusted odds ratio, 3.5; 95% CI, 1.7 to 7.2; P < .001). Mean knowledge scores were higher in the intervention arm than in the control arm (3.3 ± 1.0 v 2.6 ± 1.3, respectively; P < .001), and 65 participants (93%) in the intervention arm were comfortable watching the video. Conclusion Participants with advanced cancer who viewed a video of CPR were less likely to opt for CPR than those who listened to a verbal narrative. PMID:23233708

  7. Assessing health impacts in complex eco-epidemiological settings in the humid tropics: Advancing tools and methods

    SciTech Connect

    Winkler, Mirko S.; Divall, Mark J.; Krieger, Gary R.; Balge, Marci Z.; Singer, Burton H.; Utzinger, Juerg

    2010-01-15

    In the developing world, large-scale projects in the extractive industry and natural resources sectors are often controversial and associated with long-term adverse health consequences to local communities. In many industrialised countries, health impact assessment (HIA) has been institutionalized for the mitigation of anticipated negative health effects while enhancing the benefits of projects, programmes and policies. However, in developing country settings, relatively few HIAs have been performed. Hence, more HIAs with a focus on low- and middle-income countries are needed to advance and refine tools and methods for impact assessment and subsequent mitigation measures. We present a promising HIA approach, developed within the frame of a large gold-mining project in the Democratic Republic of the Congo. The articulation of environmental health areas, the spatial delineation of potentially affected communities and the use of a diversity of sources to obtain quality baseline health data are utilized for risk profiling. We demonstrate how these tools and data are fed into a risk analysis matrix, which facilitates ranking of potential health impacts for subsequent prioritization of mitigation strategies. The outcomes encapsulate a multitude of environmental and health determinants in a systematic manner, and will assist decision-makers in the development of mitigation measures that minimize potential adverse health effects and enhance positive ones.

  8. Earth remote sensing as an effective tool for the development of advanced innovative educational technologies

    NASA Astrophysics Data System (ADS)

    Mayorova, Vera; Mayorov, Kirill

    2009-11-01

    Current educational system is facing a contradiction between the fundamentality of engineering education and the necessity of applied learning extension, which requires new methods of training to combine both academic and practical knowledge in balance. As a result there are a number of innovations being developed and implemented into the process of education aimed at optimizing the quality of the entire educational system. Among a wide range of innovative educational technologies there is an especially important subset of educational technologies which involve learning through hands-on scientific and technical projects. The purpose of this paper is to describe the implementation of educational technologies based on small satellites development as well as the usage of Earth remote sensing data acquired from these satellites. The increase in public attention to the education through Earth remote sensing is based on the concern that although there is a great progress in the development of new methods of Earth imagery and remote sensing data acquisition there is still a big question remaining open on practical applications of this kind of data. It is important to develop the new way of thinking for the new generation of people so they understand that they are the masters of their own planet and they are responsible for its state. They should desire and should be able to use a powerful set of tools based on modern and perspective Earth remote sensing. For example NASA sponsors "Classroom of the Future" project. The Universities Space Research Association in United States provides a mechanism through which US universities can cooperate effectively with one another, with the government, and with other organizations to further space science and technology, and to promote education in these areas. It also aims at understanding the Earth as a system and promoting the role of humankind in the destiny of their own planet. The Association has founded a Journal of Earth System

  9. Machine Tool Advanced Skills Technology (MAST). Common Ground: Toward a Standards-Based Training System for the U.S. Machine Tool and Metal Related Industries. Volume 11: Computer-Aided Manufacturing & Advanced CNC, of a 15-Volume Set of Skill Standards and Curriculum Training Materials for the Precision Manufacturing Industry.

    ERIC Educational Resources Information Center

    Texas State Technical Coll., Waco.

    This document is intended to help education and training institutions deliver the Machine Tool Advanced Skills Technology (MAST) curriculum to a variety of individuals and organizations. MAST consists of industry-specific skill standards and model curricula for 15 occupational specialty areas within the U.S. machine tool and metals-related…

  10. Information for Global Reach

    DTIC Science & Technology

    2005-08-01

    mobile users on the IFGR virtual network using their standard browser, e- mail tool, or mission- specific applications. This Final Report describes...application ensures only the intended recipients can read the data and can also verify the identity of the sender . Data Encryption - FIPS compliant...that can be used to drive how data is prioritized within the IFGR infrastructure. The prioritization parameters are Mission Priority, Senders Priority

  11. Oncolytic virotherapy reaches adolescence.

    PubMed

    Hammill, Adrienne M; Conner, Joseph; Cripe, Timothy P

    2010-12-15

    Lytic viruses kill cells as a consequence of their normal replication life cycle. The idea of harnessing viruses to kill cancer cells arose over a century ago, before viruses were even discovered, from medical case reports of infections associated with cancer remissions. Since then, there has been no shortage of hype, hope, or fear regarding the prospect of oncolytic virotherapy for cancer. Early developments in the field included encouraging antitumor efficacy both in animal studies in the 1920s-1940s and in human clinical trials in the 1950s-1970s. Despite its long-standing history, oncolytic virotherapy was an idea ahead of its time. Without needed advances in molecular biology, virology, immunology, and clinical research ethics, early clinical trials resulted in infectious complications and were fraught with controversial research conduct, so that enthusiasm in the medical community waned. Oncolytic virotherapy is now experiencing a major growth spurt, having sustained numerous laboratory advances and undergone multiple encouraging adult clinical trials, and is now witnessing the emergence of pediatric trials. Here we review the history and salient biology of the field, including preclinical and clinical data, with a special emphasis on those agents now being tested in pediatric cancer patients.

  12. Europe reaches the Moon

    NASA Astrophysics Data System (ADS)

    2004-11-01

    A complex package of tests on new technologies was successfully performed during the cruise to the Moon, while the spacecraft was getting ready for the scientific investigations which will come next. These technologies pave the way for future planetary missions. SMART-1 reached its closest point to the lunar surface so far - its first ‘perilune’ - at an altitude of about 5000 kilometres at 18:48 Central European Time (CET) on 15 November. Just hours before that, at 06:24 CET, SMART-1’s solar-electric propulsion system (or ‘ion engine’) was started up and is now being fired for the delicate manoeuvre that will stabilise the spacecraft in lunar orbit. During this crucial phase, the engine will run almost continuously for the next four days, and then for a series of shorter burns, allowing SMART-1 to reach its final operational orbit by making ever-decreasing loops around the Moon. By about mid-January, SMART-1 will be orbiting the Moon at altitudes between 300 kilometres (over the lunar south pole) and 3000 kilometres (over the lunar north pole), beginning its scientific observations. The main purpose of the first part of the SMART-1 mission, concluding with the arrival at the Moon, was to demonstrate new spacecraft technologies. In particular, the solar-electric propulsion system was tested over a long spiralling trip to the Moon of more than 84 million kilometres. This is a distance comparable to an interplanetary cruise. For the first time ever, gravity-assist manoeuvres, which use the gravitational pull of the approaching Moon, were performed by an electrically-propelled spacecraft. The success of this test is important to the prospects for future interplanetary missions using ion engines. SMART-1 has demonstrated new techniques for eventually achieving autonomous spacecraft navigation. The OBAN experiment tested navigation software on ground computers to determine the exact position and velocity of the spacecraft using images of celestial objects taken

  13. Machine Tool Advanced Skills Technology (MAST). Common Ground: Toward a Standards-Based Training System for the U.S. Machine Tool and Metal Related Industries. Volume 9: Tool and Die, of a 15-Volume Set of Skill Standards and Curriculum Training Materials for the Precision Manufacturing Industry.

    ERIC Educational Resources Information Center

    Texas State Technical Coll., Waco.

    This document is intended to help education and training institutions deliver the Machine Tool Advanced Skills Technology (MAST) curriculum to a variety of individuals and organizations. MAST consists of industry-specific skill standards and model curricula for 15 occupational specialty areas within the U.S. machine tool and metals-related…

  14. Reaching Beyond The Stars

    NASA Astrophysics Data System (ADS)

    Baker, Mariah; Rosenthal, L.; Gaughan, A.; Hopkins, E.

    2014-01-01

    Strawbridge Observatory at Haverford College is home to a undergraduate-led public observing program. Our program holds ~once monthly public events throughout the academic year that take advantage of eyepiece observing on our 16-inch and 12-inch telescopes as well as of the classroom, library, and projection system. These resources allow us to organize a variety of astronomy related activities that are engaging for individuals of all ages: accessible student talks, current film screenings and even arts and crafts for the families who attend with young children. These events aim to spark curiosity in others about scientific discovery and about the remarkable nature of the world in which we live. In addition to exciting local families about astronomy, this program has excited Haverford students from a range of disciplines about both science and education. Being entirely student led means that we are able to take the initiative in planning, coordinating and running all events, fostering an atmosphere of collaboration, experimentation and commitment amongst our volunteers. Additionally, this program is one of the few at Haverford that regularly reaches beyond the campus walls to promote and build relationships with the outside community. In light of this, our program presents a distinctive and enlightening opportunity for student volunteers: we get to use our scientific backgrounds to educate a general audience, while also learning from them about how to communicate and inspire in others the excitement we feel about the subject of astronomy. The work on this project has been supported by NSF AST-1151462.

  15. Image navigation and registration performance assessment tool set for the GOES-R Advanced Baseline Imager and Geostationary Lightning Mapper

    NASA Astrophysics Data System (ADS)

    De Luccia, Frank J.; Houchin, Scott; Porter, Brian C.; Graybill, Justin; Haas, Evan; Johnson, Patrick D.; Isaacson, Peter J.; Reth, Alan D.

    2016-05-01

    The GOES-R Flight Project has developed an Image Navigation and Registration (INR) Performance Assessment Tool Set (IPATS) for measuring Advanced Baseline Imager (ABI) and Geostationary Lightning Mapper (GLM) INR performance metrics in the post-launch period for performance evaluation and long term monitoring. For ABI, these metrics are the 3-sigma errors in navigation (NAV), channel-to-channel registration (CCR), frame-to-frame registration (FFR), swath-to-swath registration (SSR), and within frame registration (WIFR) for the Level 1B image products. For GLM, the single metric of interest is the 3-sigma error in the navigation of background images (GLM NAV) used by the system to navigate lightning strikes. 3-sigma errors are estimates of the 99. 73rd percentile of the errors accumulated over a 24 hour data collection period. IPATS utilizes a modular algorithmic design to allow user selection of data processing sequences optimized for generation of each INR metric. This novel modular approach minimizes duplication of common processing elements, thereby maximizing code efficiency and speed. Fast processing is essential given the large number of sub-image registrations required to generate INR metrics for the many images produced over a 24 hour evaluation period. Another aspect of the IPATS design that vastly reduces execution time is the off-line propagation of Landsat based truth images to the fixed grid coordinates system for each of the three GOES-R satellite locations, operational East and West and initial checkout locations. This paper describes the algorithmic design and implementation of IPATS and provides preliminary test results.

  16. Image Navigation and Registration Performance Assessment Tool Set for the GOES-R Advanced Baseline Imager and Geostationary Lightning Mapper

    NASA Technical Reports Server (NTRS)

    De Luccia, Frank J.; Houchin, Scott; Porter, Brian C.; Graybill, Justin; Haas, Evan; Johnson, Patrick D.; Isaacson, Peter J.; Reth, Alan D.

    2016-01-01

    The GOES-R Flight Project has developed an Image Navigation and Registration (INR) Performance Assessment Tool Set (IPATS) for measuring Advanced Baseline Imager (ABI) and Geostationary Lightning Mapper (GLM) INR performance metrics in the post-launch period for performance evaluation and long term monitoring. For ABI, these metrics are the 3-sigma errors in navigation (NAV), channel-to-channel registration (CCR), frame-to-frame registration (FFR), swath-to-swath registration (SSR), and within frame registration (WIFR) for the Level 1B image products. For GLM, the single metric of interest is the 3-sigma error in the navigation of background images (GLM NAV) used by the system to navigate lightning strikes. 3-sigma errors are estimates of the 99.73rd percentile of the errors accumulated over a 24-hour data collection period. IPATS utilizes a modular algorithmic design to allow user selection of data processing sequences optimized for generation of each INR metric. This novel modular approach minimizes duplication of common processing elements, thereby maximizing code efficiency and speed. Fast processing is essential given the large number of sub-image registrations required to generate INR metrics for the many images produced over a 24-hour evaluation period. Another aspect of the IPATS design that vastly reduces execution time is the off-line propagation of Landsat based truth images to the fixed grid coordinates system for each of the three GOES-R satellite locations, operational East and West and initial checkout locations. This paper describes the algorithmic design and implementation of IPATS and provides preliminary test results.

  17. The REACH Youth Program Learning Toolkit

    ERIC Educational Resources Information Center

    Sierra Health Foundation, 2011

    2011-01-01

    Believing in the value of using video documentaries and data as learning tools, members of the REACH technical assistance team collaborated to develop this toolkit. The learning toolkit was designed using and/or incorporating components of the "Engaging Youth in Community Change: Outcomes and Lessons Learned from Sierra Health Foundation's…

  18. SU-E-T-398: Feasibility of Automated Tools for Robustness Evaluation of Advanced Photon and Proton Techniques in Oropharyngeal Cancer

    SciTech Connect

    Liu, H; Liang, X; Kalbasi, A; Lin, A; Ahn, P; Both, S

    2014-06-01

    Purpose: Advanced radiotherapy (RT) techniques such as proton pencil beam scanning (PBS) and photon-based volumetric modulated arc therapy (VMAT) have dosimetric advantages in the treatment of head and neck malignancies. However, anatomic or alignment changes during treatment may limit robustness of PBS and VMAT plans. We assess the feasibility of automated deformable registration tools for robustness evaluation in adaptive PBS and VMAT RT of oropharyngeal cancer (OPC). Methods: We treated 10 patients with bilateral OPC with advanced RT techniques and obtained verification CT scans with physician-reviewed target and OAR contours. We generated 3 advanced RT plans for each patient: proton PBS plan using 2 posterior oblique fields (2F), proton PBS plan using an additional third low-anterior field (3F), and a photon VMAT plan using 2 arcs (Arc). For each of the planning techniques, we forward calculated initial (Ini) plans on the verification scans to create verification (V) plans. We extracted DVH indicators based on physician-generated contours for 2 target and 14 OAR structures to investigate the feasibility of two automated tools (contour propagation (CP) and dose deformation (DD)) as surrogates for routine clinical plan robustness evaluation. For each verification scan, we compared DVH indicators of V, CP and DD plans in a head-to-head fashion using Student's t-test. Results: We performed 39 verification scans; each patient underwent 3 to 6 verification scan. We found no differences in doses to target or OAR structures between V and CP, V and DD, and CP and DD plans across all patients (p > 0.05). Conclusions: Automated robustness evaluation tools, CP and DD, accurately predicted dose distributions of verification (V) plans using physician-generated contours. These tools may be further developed as a potential robustness screening tool in the workflow for adaptive treatment of OPC using advanced RT techniques, reducing the need for physician-generated contours.

  19. Innovative and Advanced Coupled Neutron Transport and Thermal Hydraulic Method (Tool) for the Design, Analysis and Optimization of VHTR/NGNP Prismatic Reactors

    SciTech Connect

    Rahnema, Farzad; Garimeela, Srinivas; Ougouag, Abderrafi; Zhang, Dingkang

    2013-11-29

    This project will develop a 3D, advanced coarse mesh transport method (COMET-Hex) for steady- state and transient analyses in advanced very high-temperature reactors (VHTRs). The project will lead to a coupled neutronics and thermal hydraulic (T/H) core simulation tool with fuel depletion capability. The computational tool will be developed in hexagonal geometry, based solely on transport theory without (spatial) homogenization in complicated 3D geometries. In addition to the hexagonal geometry extension, collaborators will concurrently develop three additional capabilities to increase the code’s versatility as an advanced and robust core simulator for VHTRs. First, the project team will develop and implement a depletion method within the core simulator. Second, the team will develop an elementary (proof-of-concept) 1D time-dependent transport method for efficient transient analyses. The third capability will be a thermal hydraulic method coupled to the neutronics transport module for VHTRs. Current advancements in reactor core design are pushing VHTRs toward greater core and fuel heterogeneity to pursue higher burn-ups, efficiently transmute used fuel, maximize energy production, and improve plant economics and safety. As a result, an accurate and efficient neutron transport, with capabilities to treat heterogeneous burnable poison effects, is highly desirable for predicting VHTR neutronics performance. This research project’s primary objective is to advance the state of the art for reactor analysis.

  20. The Reach Address Database (RAD)

    EPA Pesticide Factsheets

    The Reach Address Database (RAD) stores reach address information for each Water Program feature that has been linked to the underlying surface water features (streams, lakes, etc) in the National Hydrology Database (NHD) Plus dataset.

  1. Machine Tool Advanced Skills Technology (MAST). Common Ground: Toward a Standards-Based Training System for the U.S. Machine Tool and Metal Related Industries. Volume 1: Executive Summary, of a 15-Volume Set of Skills Standards and Curriculum Training Materials for the Precision Manufacturing Industry.

    ERIC Educational Resources Information Center

    Texas State Technical Coll., Waco.

    The Machine Tool Advanced Skills Technology (MAST) consortium was formed to address the shortage of skilled workers for the machine tools and metals-related industries. Featuring six of the nation's leading advanced technology centers, the MAST consortium developed, tested, and disseminated industry-specific skill standards and model curricula for…

  2. JUST in time health emergency interventions: an innovative approach to training the citizen for emergency situations using virtual reality techniques and advanced IT tools (the VR Tool).

    PubMed

    Manganas, A; Tsiknakis, M; Leisch, E; Ponder, M; Molet, T; Herbelin, B; Magnetat-Thalmann, N; Thalmann, D; Fato, M; Schenone, A

    2004-01-01

    This paper reports the results of the second of the two systems developed by JUST, a collaborative project supported by the European Union under the Information Society Technologies (IST) Programme. The most innovative content of the project has been the design and development of a complementary training course for non-professional health emergency operators, which supports the traditional learning phase, and which purports to improve the retention capability of the trainees. This was achieved with the use of advanced information technology techniques, which provide adequate support and can help to overcome the present weaknesses of the existing training mechanisms.

  3. An approach for the delineation of a generic cut-off value for local respiratory tract irritation by irritating or corrosive substances as a pragmatic tool to fulfill REACH requirements.

    PubMed

    Messinger, H

    2014-04-01

    Under the current European legislation for the Registration, Evaluation, Authorisation and restriction of Chemicals (REACHs) a Derived No Effect Level (DNEL) has to be delineated for acute and chronic inhalation effects. The majority of available experimental studies are performed by the oral route of exposure. Route to route extrapolation poses particular problems for irritating or corrosive substances but the necessity for additional animal studies with inhalation exposure needs to be balanced with the regulatory information requirements. Existing occupational exposure limits (OEL) as surrogate for cut-off limits representing safe exposure under working conditions were grouped under certain criteria for substances that are legally classified in Europe as irritating or corrosive. As a result, it was shown that the OEL for irritating substances in this dataset is not lower than 10mg/m(3) and for corrosives not lower than 1mg/m(3). Under certain conditions these generic limits could be applied as a pragmatic, but still sufficiently reliable and protective upper cut-off limit approach to avoid additional animal tests with irritating or corrosive chemicals. The respective systemic toxicity profiles and physical-chemical properties need to be considered. Specific exclusion criteria for the discussed concept apply.

  4. Use of advanced earth observation tools for the analyses of recent surface changes in Kalahari pans and Namibian coastal lagoons

    NASA Astrophysics Data System (ADS)

    Behling, Robert; Milewski, Robert; Chabrillat, Sabine; Völkel, Jörg

    2016-04-01

    The remote sensing analyses in the BMBF-SPACES collaborative project Geoarchives - Signals of Climate and Landscape Change preserved in Southern African Geoarchives - focuses on the use of recent and upcoming Earth Observation Tools for the study of climate and land use changes and its impact on the ecosystem. It aims at demonstrating the potential of recently available advanced optical remote sensing imagery with its extended spectral coverage and temporal resolution for the identification and mapping of sediment features associated with paleo-environmental archives as well as their recent dynamic. In this study we focus on the analyses of two ecosystems of major interest, the Kalahari salt pans as well as the lagoons at Namibia's west coast, that present high dynamic caused by combined hydrological and surface processes linked to climatic events. Multitemporal remote sensing techniques allow us to derive the recent surface dynamic of the salt pans and also provide opportunities to get a detailed understanding of the spatiotemporal development of the coastal lagoons. Furthermore spaceborne hyperspectral analysis can give insight to the current surface mineralogy of the salt pans on a physical basis and provide the intra pan distribution of evaporites. The soils and sediments of the Kalahari salt pans such as the Omongwa pan are a potentially significant storage of global carbon and also function as an important terrestrial climate archive. Thus far the surface distribution of evaporites have been only assessed mono-temporally and on a coarse regional scale, but the dynamic of the salt pans, especially the formation of evaporites, is still uncertain and poorly understood. For the salt pan analyses a change detection is applied using the Iterative-reweighted Multivariate Alteration Detection (IR-MAD) method to identify and investigate surface changes based on a Landsat time-series covering the period 1984-2015. Furthermore the current spatial distribution of

  5. Using Advanced Monitoring Tools to Evaluate PM PM2.5 2.5 in San Joaquin Valley

    EPA Science Inventory

    One of the primary data deficiencies that prevent the advance of policy relevant research on particulate matter, ozone, and associated precursors is the lack of measurement data and knowledge on the true vertical profile and synoptic-scale spatial distributions of the pollutants....

  6. Bridging the Gap 10 Years Later: A Tool and Technique to Analyze and Evaluate Advanced Academic Curricular Units

    ERIC Educational Resources Information Center

    Beasley, Jennifer G.; Briggs, Christine; Pennington, Leighann

    2017-01-01

    The need for a shared vision concerning exemplary curricula for academically advanced learners must be a priority in the field of education. With the advent of the Common Core State Standards adoption in many states, a new conversation has been ignited over meeting the needs of students with gifts and talents for whom the "standard"…

  7. Advanced CNC and CAM Series. Educational Resources for the Machine Tool Industry. Course Syllabi, Instructor's Handbook [and] Student Laboratory Manual.

    ERIC Educational Resources Information Center

    Texas State Technical Coll. System, Waco.

    This package consists of course syllabi, an instructor's handbook, and student laboratory manual for a 1-year vocational training program to prepare students for entry-level positions as advanced computer numerical control (CNC) and computer-assisted manufacturing (CAM) technicians.. The program was developed through a modification of the DACUM…

  8. Impact of gastrointestinal parasitic nematodes of sheep, and the role of advanced molecular tools for exploring epidemiology and drug resistance - an Australian perspective.

    PubMed

    Roeber, Florian; Jex, Aaron R; Gasser, Robin B

    2013-05-27

    Parasitic nematodes (roundworms) of small ruminants and other livestock have major economic impacts worldwide. Despite the impact of the diseases caused by these nematodes and the discovery of new therapeutic agents (anthelmintics), there has been relatively limited progress in the development of practical molecular tools to study the epidemiology of these nematodes. Specific diagnosis underpins parasite control, and the detection and monitoring of anthelmintic resistance in livestock parasites, presently a major concern around the world. The purpose of the present article is to provide a concise account of the biology and knowledge of the epidemiology of the gastrointestinal nematodes (order Strongylida), from an Australian perspective, and to emphasize the importance of utilizing advanced molecular tools for the specific diagnosis of nematode infections for refined investigations of parasite epidemiology and drug resistance detection in combination with conventional methods. It also gives a perspective on the possibility of harnessing genetic, genomic and bioinformatic technologies to better understand parasites and control parasitic diseases.

  9. Impact of gastrointestinal parasitic nematodes of sheep, and the role of advanced molecular tools for exploring epidemiology and drug resistance - an Australian perspective

    PubMed Central

    2013-01-01

    Parasitic nematodes (roundworms) of small ruminants and other livestock have major economic impacts worldwide. Despite the impact of the diseases caused by these nematodes and the discovery of new therapeutic agents (anthelmintics), there has been relatively limited progress in the development of practical molecular tools to study the epidemiology of these nematodes. Specific diagnosis underpins parasite control, and the detection and monitoring of anthelmintic resistance in livestock parasites, presently a major concern around the world. The purpose of the present article is to provide a concise account of the biology and knowledge of the epidemiology of the gastrointestinal nematodes (order Strongylida), from an Australian perspective, and to emphasize the importance of utilizing advanced molecular tools for the specific diagnosis of nematode infections for refined investigations of parasite epidemiology and drug resistance detection in combination with conventional methods. It also gives a perspective on the possibility of harnessing genetic, genomic and bioinformatic technologies to better understand parasites and control parasitic diseases. PMID:23711194

  10. Bridging Innovation and Outreach to Overcome Global Gaps in Radiation Oncology Through Information and Communication Tools, Trainee Advancement, Engaging Industry, Attention to Ethical Challenges, and Political Advocacy.

    PubMed

    Dad, Luqman; Royce, Trevor J; Morris, Zachary; Moran, Meena; Pawlicki, Todd; Khuntia, Deepak; Hardenbergh, Patricia; Cummings, Bernard; Mayr, Nina; Hu, Kenneth

    2017-04-01

    An evolving paradigm in global outreach in radiation oncology has been the implementation of a more region-specific, needs-based approach to help close the gap in radiation services to low- and middle-income countries through the use of innovative tools in information and communication technology. This report highlights 4 information and communication technology tools in action today: (1) the NCCN Framework for Resource Stratification of NCCN guidelines, (2) ASTRO e-Contouring, (3) i.treatsafely.org, and (4) ChartRounds.com. We also render special consideration to matters related to global outreach that we believe require distinct attention to help us meet the goals established by the 2011 United Nations׳ Declaration on noncommunicable diseases: (1) trainee advancement toward careers in global health, (2) ethical challenges of international outreach, (3) critical importance of political advocacy, and (4) collaboration with Industry.

  11. Self-imposed evaluation of the Helmholtz Research School MICMoR as a tool for quality assurance and advancement of a structured graduate programme

    NASA Astrophysics Data System (ADS)

    Elija Bleher, Bärbel; Schmid, Hans Peter; Scholz, Beate

    2015-04-01

    The Helmholtz Research School MICMoR (Mechanisms and Interactions of Climate Change in Mountain Regions) offers a structured graduate programme for doctoral students in the field of climate change research. It is hosted by the Institute of Meteorology and Climate Research (KIT/IMK-IFU) in Garmisch-Partenkirchen, in collaboration with 7 Bavarian partner universities and research institutions. Hence, MICMoR brings together a considerably large network with currently 20 doctoral students and 55 scientists. MICMoR offers scientific and professional skills training, provides a state-of-the-art supervision concept, and fosters international exchange and interdisciplinary collaboration. In order to develop and advance its programme, MICMoR has committed itself to a self-imposed mid-term review in its third year, to monitor to which extent its original objectives have been reached, and to explore and identify where MICMoR has room for improvement. The evaluation especially focused on recruitment, supervision, training, networking and cooperation. Carried out by an external expert (Beate Scholz from scholz ctc), the evaluation was based on a mixed methods approach, i.e. combining a quantitative survey involving all doctoral candidates as well as their supervisors and focus groups with different MICMoR stakeholders. The evaluation has brought forward some highly interesting results, pinpointing challenges and opportunities of setting up a structured doctoral programme. Overall, the evaluation proved to be a useful tool for evidence-based programme and policy planning, and demonstrated a high level of satisfaction of supervisors and fellows. Supervision, with facets ranging from disciplinary feedback to career advice, is demanding and requires strong commitment and adequate human resources development by all parties involved. Thus, MICMoR plans to offer mentor coaching and calls on supervisors and mentors to form a community of learners with their doctoral students. To

  12. FACILITATING ADVANCED URBAN METEOROLOGY AND AIR QUALITY MODELING CAPABILITIES WITH HIGH RESOLUTION URBAN DATABASE AND ACCESS PORTAL TOOLS

    EPA Science Inventory

    Information of urban morphological features at high resolution is needed to properly model and characterize the meteorological and air quality fields in urban areas. We describe a new project called National Urban Database with Access Portal Tool, (NUDAPT) that addresses this nee...

  13. A Visual Basic simulation software tool for performance analysis of a membrane-based advanced water treatment plant.

    PubMed

    Pal, P; Kumar, R; Srivastava, N; Chowdhury, J

    2014-02-01

    A Visual Basic simulation software (WATTPPA) has been developed to analyse the performance of an advanced wastewater treatment plant. This user-friendly and menu-driven software is based on the dynamic mathematical model for an industrial wastewater treatment scheme that integrates chemical, biological and membrane-based unit operations. The software-predicted results corroborate very well with the experimental findings as indicated in the overall correlation coefficient of the order of 0.99. The software permits pre-analysis and manipulation of input data, helps in optimization and exhibits performance of an integrated plant visually on a graphical platform. It allows quick performance analysis of the whole system as well as the individual units. The software first of its kind in its domain and in the well-known Microsoft Excel environment is likely to be very useful in successful design, optimization and operation of an advanced hybrid treatment plant for hazardous wastewater.

  14. Laser Nano-Neurosurgery from Gentle Manipulation to Nano-Incision of Neuronal Cells and Scaffolds: An Advanced Neurotechnology Tool

    PubMed Central

    Soloperto, Alessandro; Palazzolo, Gemma; Tsushima, Hanako; Chieregatti, Evelina; Vassalli, Massimo; Difato, Francesco

    2016-01-01

    Current optical approaches are progressing far beyond the scope of monitoring the structure and function of living matter, and they are becoming widely recognized as extremely precise, minimally-invasive, contact-free handling tools. Laser manipulation of living tissues, single cells, or even single-molecules is becoming a well-established methodology, thus founding the onset of new experimental paradigms and research fields. Indeed, a tightly focused pulsed laser source permits complex tasks such as developing engineered bioscaffolds, applying calibrated forces, transfecting, stimulating, or even ablating single cells with subcellular precision, and operating intracellular surgical protocols at the level of single organelles. In the present review, we report the state of the art of laser manipulation in neuroscience, to inspire future applications of light-assisted tools in nano-neurosurgery. PMID:27013962

  15. Laser Nano-Neurosurgery from Gentle Manipulation to Nano-Incision of Neuronal Cells and Scaffolds: An Advanced Neurotechnology Tool.

    PubMed

    Soloperto, Alessandro; Palazzolo, Gemma; Tsushima, Hanako; Chieregatti, Evelina; Vassalli, Massimo; Difato, Francesco

    2016-01-01

    Current optical approaches are progressing far beyond the scope of monitoring the structure and function of living matter, and they are becoming widely recognized as extremely precise, minimally-invasive, contact-free handling tools. Laser manipulation of living tissues, single cells, or even single-molecules is becoming a well-established methodology, thus founding the onset of new experimental paradigms and research fields. Indeed, a tightly focused pulsed laser source permits complex tasks such as developing engineered bioscaffolds, applying calibrated forces, transfecting, stimulating, or even ablating single cells with subcellular precision, and operating intracellular surgical protocols at the level of single organelles. In the present review, we report the state of the art of laser manipulation in neuroscience, to inspire future applications of light-assisted tools in nano-neurosurgery.

  16. ALMA telescope reaches new heights

    NASA Astrophysics Data System (ADS)

    2009-09-01

    The ALMA (Atacama Large Millimeter/submillimeter Array) astronomical observatory has taken another step forward - and upwards. One of its state-of-the-art antennas was carried for the first time to the 5000m plateau of Chajnantor, in the Chilean Andes, on the back of a custom-built giant transporter. The antenna, which weighs about 100 tons and has a diameter of 12 metres, was transported up to the high-altitude Array Operations Site, where the extremely dry and rarefied air is ideal for ALMA's observations of the Universe. The conditions at the Array Operations Site on Chajnantor, while excellent for astronomy, are also very harsh. Only half as much oxygen is available as at sea level, making it very difficult to work there. This is why ALMA's antennas are assembled and tested at the lower 2900 m altitude of the ALMA Operations Support Facility. It was from this relatively hospitable base camp that the ALMA antenna began its journey to the high Chajnantor site. "This is an important moment for ALMA. We are very happy that the first transport of an antenna to the high site went flawlessly. This achievement was only possible through contributions from all international ALMA partners: this particular antenna is provided by Japan, the heavy-lift transporter by Europe, and the receiving electronics inside the antenna by North America, Europe, and Asia", said Wolfgang Wild, European ALMA Project Manager. The trip began when one of the two ALMA transporters, named Otto, lifted the antenna onto its back. It then carried its heavy load along the 28 km road from the Operations Support Facility up to the Array Operations Site. While the transporter is capable of speeds of up to 12 km/hour when carrying an antenna, this first journey was made more slowly to ensure that everything worked as expected, taking about seven hours. The ALMA antennas are the most advanced submillimetre-wavelength antennas ever made. They are designed to operate fully exposed in the harsh conditions

  17. Investigation of Alien Wavelength Quality in Live Multi-Domain, Multi-Vendor Link Using Advanced Simulation Tool

    NASA Astrophysics Data System (ADS)

    Nordal Petersen, Martin; Nuijts, Roeland; Lange Bjørn, Lars

    2014-05-01

    This article presents an advanced optical model for simulation of alien wavelengths in multi-domain and multi-vendor dense wavelength-division multiplexing networks. The model aids optical network planners with a better understanding of the non-linear effects present in dense wavelength-division multiplexing systems and better utilization of alien wavelengths in future applications. The limiting physical effects for alien wavelengths are investigated in relation to power levels, channel spacing, and other factors. The simulation results are verified through experimental setup in live multi-domain dense wavelength-division multiplexing systems between two national research networks: SURFnet in Holland and NORDUnet in Denmark.

  18. Spallation Neutron Source reaches megawatt power

    SciTech Connect

    Dr. William F. Brinkman

    2009-09-30

    The Department of Energy's Spallation Neutron Source (SNS), already the world's most powerful facility for pulsed neutron scattering science, is now the first pulsed spallation neutron source to break the one-megawatt barrier. "Advances in the materials sciences are fundamental to the development of clean and sustainable energy technologies. In reaching this milestone of operating power, the Spallation Neutron Source is providing scientists with an unmatched resource for unlocking the secrets of materials at the molecular level," said Dr. William F. Brinkman, Director of DOE's Office of Science.

  19. AGU Scholarship Fund Reaches Its Goal

    NASA Astrophysics Data System (ADS)

    Howard, Claire

    2014-11-01

    The Edmond M. Dewan Young Scientist Scholarship fund has reached its goal of $25,000. Those who donated to the fund share AGU's mission in taking an active role in educating and nurturing the next generation of scientists and ensuring a sustainable future for society. Thanks to the generosity of more than 100 members of the AGU and science community, a deserving graduate student of atmospheric or space physics will receive financial assistance to further his or her research and advance his or her research and future career.

  20. Spallation Neutron Source reaches megawatt power

    ScienceCinema

    Dr. William F. Brinkman

    2016-07-12

    The Department of Energy's Spallation Neutron Source (SNS), already the world's most powerful facility for pulsed neutron scattering science, is now the first pulsed spallation neutron source to break the one-megawatt barrier. "Advances in the materials sciences are fundamental to the development of clean and sustainable energy technologies. In reaching this milestone of operating power, the Spallation Neutron Source is providing scientists with an unmatched resource for unlocking the secrets of materials at the molecular level," said Dr. William F. Brinkman, Director of DOE's Office of Science.

  1. Recent advances in elementary flux modes and yield space analysis as useful tools in metabolic network studies.

    PubMed

    Horvat, Predrag; Koller, Martin; Braunegg, Gerhart

    2015-09-01

    A review of the use of elementary flux modes (EFMs) and their applications in metabolic engineering covered with yield space analysis (YSA) is presented. EFMs are an invaluable tool in mathematical modeling of biochemical processes. They are described from their inception in 1994, followed by various improvements of their computation in later years. YSA constitutes another precious tool for metabolic network modeling, and is presented in details along with EFMs in this article. The application of these techniques is discussed for several case studies of metabolic network modeling provided in respective original articles. The article is concluded by some case studies in which the application of EFMs and YSA turned out to be most useful, such as the analysis of intracellular polyhydroxyalkanoate (PHA) formation and consumption in Cupriavidus necator, including the constraint-based description of the steady-state flux cone of the strain's metabolic network, the profound analysis of a continuous five-stage bioreactor cascade for PHA production by C. necator using EFMs and, finally, the study of metabolic fluxes in the metabolic network of C. necator cultivated on glycerol.

  2. Development of Advanced Verification and Validation Procedures and Tools for the Certification of Learning Systems in Aerospace Applications

    NASA Technical Reports Server (NTRS)

    Jacklin, Stephen; Schumann, Johann; Gupta, Pramod; Richard, Michael; Guenther, Kurt; Soares, Fola

    2005-01-01

    Adaptive control technologies that incorporate learning algorithms have been proposed to enable automatic flight control and vehicle recovery, autonomous flight, and to maintain vehicle performance in the face of unknown, changing, or poorly defined operating environments. In order for adaptive control systems to be used in safety-critical aerospace applications, they must be proven to be highly safe and reliable. Rigorous methods for adaptive software verification and validation must be developed to ensure that control system software failures will not occur. Of central importance in this regard is the need to establish reliable methods that guarantee convergent learning, rapid convergence (learning) rate, and algorithm stability. This paper presents the major problems of adaptive control systems that use learning to improve performance. The paper then presents the major procedures and tools presently developed or currently being developed to enable the verification, validation, and ultimate certification of these adaptive control systems. These technologies include the application of automated program analysis methods, techniques to improve the learning process, analytical methods to verify stability, methods to automatically synthesize code, simulation and test methods, and tools to provide on-line software assurance.

  3. ALMA Telescope Reaches New Heights

    NASA Astrophysics Data System (ADS)

    2009-09-01

    ball at a distance of nine miles, and to keep their smooth reflecting surfaces accurate to less than the thickness of a human hair. Once the transporter reached the high plateau it carried the antenna to a concrete pad -- a docking station with connections for power and fiber optics -- and positioned it with an accuracy of a small fraction of an inch. The transporter is guided by a laser steering system and, just like some cars, also has ultrasonic collision detectors. These sensors ensure the safety of the state-of-the-art antennas as the transporter drives them across what will soon be a rather crowded plateau. Ultimately, ALMA will have at least 66 antennas distributed over about 200 pads, spread over distances of up to 11.5 miles and operating as a single, giant telescope. Even when ALMA is fully operational, the transporters will be used to move the antennas between pads to reconfigure the telescope for different kinds of observations. This first ALMA antenna at the high site will soon be joined by others, and the ALMA team looks forward to making their first observations from the Chajnantor plateau. They plan to link three antennas by early 2010, and to make the first scientific observations with ALMA in the second half of 2011. ALMA will help astronomers answer important questions about our cosmic origins. The telescope will observe the Universe using light with millimeter and submillimeter wavelengths, between infrared light and radio waves in the electromagnetic spectrum. Light at these wavelengths comes from some of the coldest, and from some of the most distant objects in the cosmos. These include cold clouds of gas and dust where new stars are being born, or remote galaxies towards the edge of the observable universe. The Universe is relatively unexplored at submillimeter wavelengths, as the telescopes need extremely dry atmospheric conditions, such as those at Chajnantor, and advanced detector technology. The Atacama Large Millimeter/submillimeter Array

  4. A Demonstration of Advanced Safety Analysis Tools and Methods Applied to Large Break LOCA and Fuel Analysis for PWRs

    SciTech Connect

    Szilard, Ronaldo Henriques; Smith, Curtis Lee; Martineau, Richard Charles

    2016-03-01

    The U.S. Nuclear Regulatory Commission (NRC) is currently proposing a rulemaking designated as 10 CFR 50.46c to revise the loss-of-coolant accident (LOCA)/emergency core cooling system acceptance criteria to include the effects of higher burnup on fuel/cladding performance. We propose a demonstration problem of a representative four-loop PWR plant to study the impact of this new rule in the US nuclear fleet. Within the scope of evaluation for the 10 CFR 50.46c rule, aspects of safety, operations, and economics are considered in the industry application demonstration presented in this paper. An advanced safety analysis approach is used, by integrating the probabilistic element with deterministic methods for LOCA analysis, a novel approach to solving these types of multi-physics, multi-scale problems.

  5. MO-E-18C-04: Advanced Computer Simulation and Visualization Tools for Enhanced Understanding of Core Medical Physics Concepts

    SciTech Connect

    Naqvi, S

    2014-06-15

    Purpose: Most medical physics programs emphasize proficiency in routine clinical calculations and QA. The formulaic aspect of these calculations and prescriptive nature of measurement protocols obviate the need to frequently apply basic physical principles, which, therefore, gradually decay away from memory. E.g. few students appreciate the role of electron transport in photon dose, making it difficult to understand key concepts such as dose buildup, electronic disequilibrium effects and Bragg-Gray theory. These conceptual deficiencies manifest when the physicist encounters a new system, requiring knowledge beyond routine activities. Methods: Two interactive computer simulation tools are developed to facilitate deeper learning of physical principles. One is a Monte Carlo code written with a strong educational aspect. The code can “label” regions and interactions to highlight specific aspects of the physics, e.g., certain regions can be designated as “starters” or “crossers,” and any interaction type can be turned on and off. Full 3D tracks with specific portions highlighted further enhance the visualization of radiation transport problems. The second code calculates and displays trajectories of a collection electrons under arbitrary space/time dependent Lorentz force using relativistic kinematics. Results: Using the Monte Carlo code, the student can interactively study photon and electron transport through visualization of dose components, particle tracks, and interaction types. The code can, for instance, be used to study kerma-dose relationship, explore electronic disequilibrium near interfaces, or visualize kernels by using interaction forcing. The electromagnetic simulator enables the student to explore accelerating mechanisms and particle optics in devices such as cyclotrons and linacs. Conclusion: The proposed tools are designed to enhance understanding of abstract concepts by highlighting various aspects of the physics. The simulations serve as

  6. Process variation monitoring (PVM) by wafer inspection tool as a complementary method to CD-SEM for mapping field CDU on advanced production devices

    NASA Astrophysics Data System (ADS)

    Kim, Dae Jong; Yoo, Hyung Won; Kim, Chul Hong; Lee, Hak Kwon; Kim, Sung Su; Bae, Koon Ho; Spielberg, Hedvi; Lee, Yun Ho; Levi, Shimon; Bustan, Yariv; Rozentsvige, Moshe

    2010-03-01

    As design rules shrink, Critical Dimension Uniformity (CDU) and Line Edge Roughness (LER) have a dramatic effect on printed final lines and hence the need to control these parameters increases. Sources of CDU and LER variations include scanner auto-focus accuracy and stability, layer stack thickness, composition variations, and exposure variations. Process variations, in advanced VLSI production designs, specifically in memory devices, attributed to CDU and LER affect cell-to-cell parametric variations. These variations significantly impact device performance and die yield. Traditionally, measurements of LER are performed by CD-SEM or OCD metrology tools. Typically, these measurements require a relatively long time to set and cover only selected points of wafer area. In this paper we present the results of a collaborative work of the Process Diagnostic & Control Business Unit of Applied Materials and Hynix Semiconductor Inc. on the implementation of a complementary method to the CDSEM and OCD tools, to monitor defect density and post litho develop CDU and LER on production wafers. The method, referred to as Process Variation Monitoring (PVM) is based on measuring variations in the scattered light from periodic structures. The application is demonstrated using Applied Materials DUV bright field (BF) wafer inspection tool under optimized illumination and collection conditions. The UVisionTM has already passed a successful feasibility study on DRAM products with 66nm and 54nm design rules. The tool has shown high sensitivity to variations across an FEM wafer in both exposure and focus axes. In this article we show how PVM can help detection of Field to Field variations on DRAM wafers with 44nm design rule during normal production run. The complex die layout and the shrink in cell dimensions require high sensitivity to local variations within Dies or Fields. During normal scan of production wafers local Process variations are translated into GL (Grey Level) values

  7. Machine Tool Advanced Skills Technology (MAST). Common Ground: Toward a Standards-Based Training System for the U.S. Machine Tool and Metal Related Industries. Volume 13: Laser Machining, of a 15-Volume Set of Skill Standards and Curriculum Training Materials for the Precision Manufacturing Industry.

    ERIC Educational Resources Information Center

    Texas State Technical Coll., Waco.

    This document is intended to help education and training institutions deliver the Machine Tool Advanced Skills Technology (MAST) curriculum to a variety of individuals and organizations. MAST consists of industry-specific skill standards and model curricula for 15 occupational specialty areas within the U.S. machine tool and metals-related…

  8. Machine Tool Advanced Skills Technology (MAST). Common Ground: Toward a Standards-Based Training System for the U.S. Machine Tool and Metal Related Industries. Volume 12: Instrumentation, of a 15-Volume Set of Skill Standards and Curriculum Training Materials for the Precision Manufacturing Industry.

    ERIC Educational Resources Information Center

    Texas State Technical Coll., Waco.

    This document is intended to help education and training institutions deliver the Machine Tool Advanced Skills Technology (MAST) curriculum to a variety of individuals and organizations. MAST consists of industry-specific skill standards and model curricula for 15 occupational specialty areas within the U.S. machine tool and metals-related…

  9. Machine Tool Advanced Skills Technology (MAST). Common Ground: Toward a Standards-Based Training System for the U.S. Machine Tool and Metal Related Industries. Volume 14: Automated Equipment Technician (CIM), of a 15-Volume Set of Skill Standards and Curriculum Training Materials for the Precision Manufacturing Industry.

    ERIC Educational Resources Information Center

    Texas State Technical Coll., Waco.

    This document is intended to help education and training institutions deliver the Machine Tool Advanced Skills Technology (MAST) curriculum to a variety of individuals and organizations. MAST consists of industry-specific skill standards and model curricula for 15 occupational specialty areas within the U.S. machine tool and metals-related…

  10. Machine Tool Advanced Skills Technology (MAST). Common Ground: Toward a Standards-Based Training System for the U.S. Machine Tool and Metal Related Industries. Volume 3: Machining, of a 15-Volume Set of Skill Standards and Curriculum Training Materials for the Precision Manufacturing Industry.

    ERIC Educational Resources Information Center

    Texas State Technical Coll., Waco.

    This document is intended to help education and training institutions deliver the Machine Tool Advanced Skills Technology (MAST) curriculum to a variety of individuals and organizations. MAST consists of industry-specific skill standards and model curricula for 15 occupational specialty areas within the U.S. machine tool and metals-related…

  11. Machine Tool Advanced Skills Technology (MAST). Common Ground: Toward a Standards-Based Training System for the U.S. Machine Tool and Metal Related Industries. Volume 15: Administrative Information, of a 15-Volume Set of Skill Standards and Curriculum Training Materials for the Precision Manufacturing Industry.

    ERIC Educational Resources Information Center

    Texas State Technical Coll., Waco.

    This volume developed by the Machine Tool Advanced Skill Technology (MAST) program contains key administrative documents and provides additional sources for machine tool and precision manufacturing information and important points of contact in the industry. The document contains the following sections: a foreword; grant award letter; timeline for…

  12. Machine Tool Advanced Skills Technology (MAST). Common Ground: Toward a Standards-Based Training System for the U.S. Machine Tool and Metal Related Industries. Volume 10: Computer-Aided Drafting & Design, of a 15-Volume Set of Skill Standards and Curriculum Training Materials for the Precision Manufacturing Industry.

    ERIC Educational Resources Information Center

    Texas State Technical Coll., Waco.

    This document is intended to help education and training institutions deliver the Machine Tool Advanced Skills Technology (MAST) curriculum to a variety of individuals and organizations. MAST consists of industry-specific skill standards and model curricula for 15 occupational specialty areas within the U.S. machine tool and metals-related…

  13. Machine Tool Advanced Skills Technology (MAST). Common Ground: Toward a Standards-Based Training System for the U.S. Machine Tool and Metal Related Industries. Volume 7: Industrial Maintenance Technology, of a 15-Volume Set of Skill Standards and Curriculum Training Materials for the Precision Manufacturing Industry.

    ERIC Educational Resources Information Center

    Texas State Technical Coll., Waco.

    This document is intended to help education and training institutions deliver the Machine Tool Advanced Skills Technology (MAST) curriculum to a variety of individuals and organizations. MAST consists of industry-specific skill standards and model curricula for 15 occupational specialty areas within the U.S. machine tool and metals-related…

  14. Machine Tool Advanced Skills Technology (MAST). Common Ground: Toward a Standards-Based Training System for the U.S. Machine Tool and Metal Related Industries. Volume 6: Welding, of a 15-Volume Set of Skill Standards and Curriculum Training Materials for the Precision Manufacturing Industry.

    ERIC Educational Resources Information Center

    Texas State Technical Coll., Waco.

    This document is intended to help education and training institutions deliver the Machine Tool Advanced Skills Technology (MAST) curriculum to a variety of individuals and organizations. MAST consists of industry-specific skill standards and model curricula for 15 occupational specialty areas within the U.S. machine tool and metals-related…

  15. Machine Tool Advanced Skills Technology (MAST). Common Ground: Toward a Standards-Based Training System for the U.S. Machine Tool and Metal Related Industries. Volume 8: Sheet Metal & Composites, of a 15-Volume Set of Skill Standards and Curriculum Training Materials for the Precision Manufacturing Industry.

    ERIC Educational Resources Information Center

    Texas State Technical Coll., Waco.

    This document is intended to help education and training institutions deliver the Machine Tool Advanced Skills Technology (MAST) curriculum to a variety of individuals and organizations. MAST consists of industry-specific skill standards and model curricula for 15 occupational specialty areas within the U.S. machine tool and metals-related…

  16. Machine Tool Advanced Skills Technology (MAST). Common Ground: Toward a Standards-Based Training System for the U.S. Machine Tool and Metal Related Industries. Volume 5: Mold Making, of a 15-Volume Set of Skill Standards and Curriculum Training Materials for the Precision Manufacturing Industry.

    ERIC Educational Resources Information Center

    Texas State Technical Coll., Waco.

    This document is intended to help education and training institutions deliver the Machine Tool Advanced Skills Technology (MAST) curriculum to a variety of individuals and organizations. MAST consists of industry-specific skill standards and model curricula for 15 occupational speciality areas within the U.S. machine tool and metals-related…

  17. Machine Tool Advanced Skills Technology (MAST). Common Ground: Toward a Standards-Based Training System for the U.S. Machine Tool and Metal Related Industries. Volume 2: Career Development, General Education and Remediation, of a 15-Volume Set of Skill Standards and Curriculum Training Materials for the Precision Manufacturing Industry.

    ERIC Educational Resources Information Center

    Texas State Technical Coll., Waco.

    This document is intended to help education and training institutions deliver the Machine Tool Advanced Skills Technology (MAST) curriculum to a variety of individuals and organizations. MAST consists of industry-specific skill standards and model curricula for 15 occupational specialty areas within the U.S. machine tool and metals-related…

  18. Machine Tool Advanced Skills Technology (MAST). Common Ground: Toward a Standards-Based Training System for the U.S. Machine Tool and Metal Related Industries. Volume 4: Manufacturing Engineering Technology, of a 15-Volume Set of Skill Standards and Curriculum Training Materials for the Precision Manufacturing Industry.

    ERIC Educational Resources Information Center

    Texas State Technical Coll., Waco.

    This document is intended to help education and training institutions deliver the Machine Tool Advanced Skills Technology (MAST) curriculum to a variety of individuals and organizations. MAST consists of industry-specific skill standards and model curricula for 15 occupational specialty areas within the U.S. machine tool and metals-related…

  19. Reaching All Students with Mathematics.

    ERIC Educational Resources Information Center

    Cuevas, Gilbert, Ed.; Driscoll, Mark, Ed.

    The National Council of Teachers of Mathematics'"Curriculum and Evaluation Standards for School Mathematics" and "Professional Standards for Teaching Mathematics" reflect the belief that all students can learn a significant core of high-quality mathematics. Recognizing the magnitude of the task of reaching all students, this…

  20. Schools Reaching Out: An Introduction.

    ERIC Educational Resources Information Center

    Heleen, Owen

    1990-01-01

    Introduces an issue devoted to the Schools Reaching Out projects at David A. Ellis School in Roxbury (MA) and Adolph S. Ochs School in New York City. Projects attempt to link the schools with parents and their communities to promote the students' academic and social success. (DM)

  1. Reaching the "iBored"

    ERIC Educational Resources Information Center

    Bauleke, Debra S.; Herrmann, Kathleen E.

    2010-01-01

    As teachers, they are always looking for creative ways to engage their students. They start the school year determined to bring to the classroom creative projects that generate student interest and foster critical thinking skills. Reaching today's Gen M student is challenging and changing the way they teach. The idea of using music to teach…

  2. The R.E.D. tools: advances in RESP and ESP charge derivation and force field library building.

    PubMed

    Dupradeau, François-Yves; Pigache, Adrien; Zaffran, Thomas; Savineau, Corentin; Lelong, Rodolphe; Grivel, Nicolas; Lelong, Dimitri; Rosanski, Wilfried; Cieplak, Piotr

    2010-07-28

    Deriving atomic charges and building a force field library for a new molecule are key steps when developing a force field required for conducting structural and energy-based analysis using molecular mechanics. Derivation of popular RESP charges for a set of residues is a complex and error prone procedure because it depends on numerous input parameters. To overcome these problems, the R.E.D. Tools (RESP and ESP charge Derive, ) have been developed to perform charge derivation in an automatic and straightforward way. The R.E.D. program handles chemical elements up to bromine in the periodic table. It interfaces different quantum mechanical programs employed for geometry optimization and computing molecular electrostatic potential(s), and performs charge fitting using the RESP program. By defining tight optimization criteria and by controlling the molecular orientation of each optimized geometry, charge values are reproduced at any computer platform with an accuracy of 0.0001 e. The charges can be fitted using multiple conformations, making them suitable for molecular dynamics simulations. R.E.D. allows also for defining charge constraints during multiple molecule charge fitting, which are used to derive charges for molecular fragments. Finally, R.E.D. incorporates charges into a force field library, readily usable in molecular dynamics computer packages. For complex cases, such as a set of homologous molecules belonging to a common family, an entire force field topology database is generated. Currently, the atomic charges and force field libraries have been developed for more than fifty model systems and stored in the RESP ESP charge DDataBase. Selected results related to non-polarizable charge models are presented and discussed.

  3. Development and implementation of a portable grating interferometer system as a standard tool for testing optics at the Advanced Photon Source beamline 1-BM.

    PubMed

    Assoufid, Lahsen; Shi, Xianbo; Marathe, Shashidhara; Benda, Erika; Wojcik, Michael J; Lang, Keenan; Xu, Ruqing; Liu, Wenjun; Macrander, Albert T; Tischler, Jon Z

    2016-05-01

    We developed a portable X-ray grating interferometer setup as a standard tool for testing optics at the Advanced Photon Source (APS) beamline 1-BM. The interferometer can be operated in phase-stepping, Moiré, or single-grating harmonic imaging mode with 1-D or 2-D gratings. All of the interferometer motions are motorized; hence, it is much easier and quicker to switch between the different modes of operation. A novel aspect of this new instrument is its designed portability. While the setup is designed to be primarily used as a standard tool for testing optics at 1-BM, it could be potentially deployed at other APS beamlines for beam coherence and wavefront characterization or imaging. The design of the interferometer system is described in detail and coherence measurements obtained at the APS 34-ID-E beamline are presented. The coherence was probed in two directions using a 2-D checkerboard, a linear, and a circular grating at X-ray energies of 8 keV, 11 keV, and 18 keV.

  4. Evaluation of contaminant removal of reverse osmosis and advanced oxidation in full-scale operation by combining passive sampling with chemical analysis and bioanalytical tools.

    PubMed

    Escher, Beate I; Lawrence, Michael; Macova, Miroslava; Mueller, Jochen F; Poussade, Yvan; Robillot, Cedric; Roux, Annalie; Gernjak, Wolfgang

    2011-06-15

    Advanced water treatment of secondary treated effluent requires stringent quality control to achieve a water quality suitable for augmenting drinking water supplies. The removal of micropollutants such as pesticides, industrial chemicals, endocrine disrupting chemicals (EDC), pharmaceuticals, and personal care products (PPCP) is paramount. As the concentrations of individual contaminants are typically low, frequent analytical screening is both laborious and costly. We propose and validate an approach for continuous monitoring by applying passive sampling with Empore disks in vessels that were designed to slow down the water flow, and thus uptake kinetics, and ensure that the uptake is only marginally dependent on the chemicals' physicochemical properties over a relatively narrow molecular size range. This design not only assured integrative sampling over 27 days for a broad range of chemicals but also permitted the use of a suite of bioanalytical tools as sum parameters, representative of mixtures of chemicals with a common mode of toxic action. Bioassays proved to be more sensitive than chemical analysis to assess the removal of organic micropollutants by reverse osmosis, followed by UV/H₂O₂ treatment, as many individual compounds fell below the quantification limit of chemical analysis, yet still contributed to the observed mixture toxicity. Nonetheless in several cases, the responses in the bioassays were also below their quantification limits and therefore only three bioassays were evaluated here, representing nonspecific toxicity and two specific end points for estrogenicity and photosynthesis inhibition. Chemical analytical techniques were able to quantify 32 pesticides, 62 PCPPs, and 12 EDCs in reverse osmosis concentrate. However, these chemicals could explain only 1% of the nonspecific toxicity in the Microtox assay in the reverse osmosis concentrate and 0.0025% in the treated water. Likewise only 1% of the estrogenic effect in the E-SCREEN could be

  5. REACH: Real-Time Data Awareness in Multi-Spacecraft Missions

    NASA Technical Reports Server (NTRS)

    Maks, Lori; Coleman, Jason; Hennessy, Joseph F. (Technical Monitor)

    2002-01-01

    NASA's Advanced Architectures and Automation Branch at the Goddard Space Flight Center (Code 588) saw the potential to reduce the cost of constellation missions by creating new user interfaces to the ground system health-and-safety data. The goal is to enable a small Flight Operations Team (FOT) to remain aware and responsive to the increased amount of ground system information in a multi-spacecraft environment. Rather than abandon the tried and true, these interfaces were developed to run alongside existing ground system software to provide additional support to the FOT. These new user interfaces have been combined in a tool called REACH. REACH-the Real-time Evaluation and Analysis of Consolidated Health-is a software product that uses advanced visualization techniques to make spacecraft anomalies easy to spot, no matter how many spacecraft are in the constellation. REACH reads numerous real-time streams of data from the ground system(s) and displays synthesized information to the FOT such that anomalies are easy to pick out and investigate.

  6. Reaching Higher--Looking Out

    ERIC Educational Resources Information Center

    Mackenzie, Christine

    2008-01-01

    The paper describes the introduction of Web 2.0 techniques and tools at the Yarra Plenty public library in Victoria, beginning with library staff. The author argues that as libraries move from Web 1.0 type delivery systems to the social networking world of Library 2.0 librarians need to deploy and make accessible these radically different systems,…

  7. Reaching for the stars: career advancement and the registered nurse.

    PubMed

    Walker, Kim

    2005-08-01

    Clinical nursing has long struggled to secure the place of primacy it deserves in the profession's hierarchy of importance and worth. It is ironic that, even at the beginning of the 21st century, a clinical nurse is generally not as well-recognized, rewarded or remunerated as a colleague working in nursing management, education or research. Until the profession recognizes and takes serious action to remedy this situation, the crisis of recruitment and retention in nursing currently ravaging the globe is likely to continue. In this paper, I present a discursive account of an exciting initiative by a leading private, acute-care hospital which addresses this very problem. A new ladder for clinical nurse specialists (CNSs) introduces a rigorous and systematic approach to the appointment of three classifications of CNS, each requiring evidence of successively higher levels of competency, and which are accompanied by fiscal reward and stronger peer recognition.

  8. Advances in molecular tools for the use of Zygosaccharomyces bailii as host for biotechnological productions and construction of the first auxotrophic mutant.

    PubMed

    Dato, Laura; Branduardi, Paola; Passolunghi, Simone; Cattaneo, Davide; Riboldi, Luca; Frascotti, Gianni; Valli, Minoska; Porro, Danilo

    2010-11-01

    The nonconventional yeast Zygosaccharomyces bailii has been proposed as a new host for biotechnological processes due to convenient properties such as its resistance to high sugar concentrations, relatively high temperatures and especially to acidic environments. We describe a series of new expression vectors specific for Z. bailii and the resulting improvements in production levels. By exploiting the sequences of the endogenous plasmid pSB2, 2microm-like multicopy vectors were obtained, giving a fivefold increase in production. A specific integrative vector was developed which led to 100% stability in the absence of selective pressure; a multiple-integration vector was constructed, based on an rRNA gene unit portion cloned and sequenced for this purpose, driving the insertion of up to 80 copies of the foreign construct. Moreover, we show the construction of the first stable auxotrophic mutant of Z. bailii, obtained by targeted gene deletion applied to ZbLEU2. The development of molecular tools for the Z. bailii manipulation has now reached a level that may be compatible with its industrial exploitation; the production of organic acids is a prominent field of application.

  9. From models to advanced 4D visualization tools: Developing a comprehensive framework for collaborative research in physical modelling and hazard assessment of volcanic phenomena

    NASA Astrophysics Data System (ADS)

    Esposti Ongaro, T.; Barsotti, S.; de Michieli Vitturi, M.; Favalli, M.; Longo, A.; Nannipieri, L.; Neri, A.; Papale, P.; Saccorotti, G.; Tarquini, S.

    2009-04-01

    The use of numerical models in volcanological research and volcanic hazard assessment is indispensable to cope with the variety of processes and interactions characterizing magma evolution and eruption dynamics, which are dominated by non-linear phenomena and cannot be modelled at full scale in the laboratory. However, new multidisciplinary problems arise when dealing with complex mathematical formulations, numerical algorithms and their implementations on modern computer architectures, so that new tools are needed for sharing knowledge, software and datasets among scientists. Additionally, the need of communicating the results from complex, physical-based models to the public and authorities requires a further effort to present them in an effective and easy way, while highlighting the strengths and limitations of the approach. Finally, availability of Geographic Information System (GIS) data represents an issue when numerical models have to be applied to real volcanoes for impact studies. We are carrying on several initiatives, started during former and ongoing national and European projects, to develop an electronic infrastructure for promoting information transfer in this field of research. In particular, a web portal, based on a dynamic Content Manager System (CMS), is under construction to host and present physical models and their applications in an extensive way (what is usually not possible in research papers), share numerical codes and simulation datasets and discuss model validation and calibration tests. Moreover, advanced 4D visualization tools have been developed to present model results in a synthetic and effective form. Finally, a web interface to GIS databases has been implemented to share and navigate geographic data. Within this framework, it will be possible to integrate physical model outcomes into a geographic context and access them via an interactive web engine such as Google-Earth.

  10. Development and validation of automatic tools for interactive recurrence analysis in radiation therapy: optimization of treatment algorithms for locally advanced pancreatic cancer

    PubMed Central

    2013-01-01

    Background In radiation oncology recurrence analysis is an important part in the evaluation process and clinical quality assurance of treatment concepts. With the example of 9 patients with locally advanced pancreatic cancer we developed and validated interactive analysis tools to support the evaluation workflow. Methods After an automatic registration of the radiation planning CTs with the follow-up images, the recurrence volumes are segmented manually. Based on these volumes the DVH (dose volume histogram) statistic is calculated, followed by the determination of the dose applied to the region of recurrence and the distance between the boost and recurrence volume. We calculated the percentage of the recurrence volume within the 80%-isodose volume and compared it to the location of the recurrence within the boost volume, boost + 1 cm, boost + 1.5 cm and boost + 2 cm volumes. Results Recurrence analysis of 9 patients demonstrated that all recurrences except one occurred within the defined GTV/boost volume; one recurrence developed beyond the field border/outfield. With the defined distance volumes in relation to the recurrences, we could show that 7 recurrent lesions were within the 2 cm radius of the primary tumor. Two large recurrences extended beyond the 2 cm, however, this might be due to very rapid growth and/or late detection of the tumor progression. Conclusion The main goal of using automatic analysis tools is to reduce time and effort conducting clinical analyses. We showed a first approach and use of a semi-automated workflow for recurrence analysis, which will be continuously optimized. In conclusion, despite the limitations of the automatic calculations we contributed to in-house optimization of subsequent study concepts based on an improved and validated target volume definition. PMID:24499557

  11. The Application of the NASA Advanced Concepts Office, Launch Vehicle Team Design Process and Tools for Modeling Small Responsive Launch Vehicles

    NASA Technical Reports Server (NTRS)

    Threet, Grady E.; Waters, Eric D.; Creech, Dennis M.

    2012-01-01

    The Advanced Concepts Office (ACO) Launch Vehicle Team at the NASA Marshall Space Flight Center (MSFC) is recognized throughout NASA for launch vehicle conceptual definition and pre-phase A concept design evaluation. The Launch Vehicle Team has been instrumental in defining the vehicle trade space for many of NASA s high level launch system studies from the Exploration Systems Architecture Study (ESAS) through the Augustine Report, Constellation, and now Space Launch System (SLS). The Launch Vehicle Team s approach to rapid turn-around and comparative analysis of multiple launch vehicle architectures has played a large role in narrowing the design options for future vehicle development. Recently the Launch Vehicle Team has been developing versions of their vetted tools used on large launch vehicles and repackaged the process and capability to apply to smaller more responsive launch vehicles. Along this development path the LV Team has evaluated trajectory tools and assumptions against sounding rocket trajectories and air launch systems, begun altering subsystem mass estimating relationships to handle smaller vehicle components, and as an additional development driver, have begun an in-house small launch vehicle study. With the recent interest in small responsive launch systems and the known capability and response time of the ACO LV Team, ACO s launch vehicle assessment capability can be utilized to rapidly evaluate the vast and opportune trade space that small launch vehicles currently encompass. This would provide a great benefit to the customer in order to reduce that large trade space to a select few alternatives that should best fit the customer s payload needs.

  12. Robot Tools

    NASA Technical Reports Server (NTRS)

    1996-01-01

    Mecanotron, now division of Robotics and Automation Corporation, developed a quick-change welding method called the Automatic Robotics Tool-change System (ARTS) under Marshall Space Flight Center and Rockwell International contracts. The ARTS system has six tool positions ranging from coarse sanding disks and abrasive wheels to cloth polishing wheels with motors of various horsepower. The system is used by fabricators of plastic body parts for the auto industry, by Texas Instruments for making radar domes, and for advanced composites at Aerospatiale in France.

  13. The Your Disease Risk Index for colorectal cancer is an inaccurate risk stratification tool for advanced colorectal neoplasia at screening colonoscopy.

    PubMed

    Schroy, Paul C; Coe, Alison M; Mylvaganam, Shamini R; Ahn, Lynne B; Lydotes, Maria A; Robinson, Patricia A; Davis, Julie T; Chen, Clara A; Ashba, Jacqueline; Atkinson, Michael L; Colditz, Graham A; Heeren, Timothy C

    2012-08-01

    Tailoring the use of screening colonoscopy based on the risk of advanced colorectal neoplasia (ACN) could optimize the cost-effectiveness of colorectal cancer (CRC) screening. Our goal was to assess the accuracy of the Your Disease Risk (YDR) CRC risk index for stratifying average risk patients into low- versus intermediate/high-risk categories for ACN. The YDR risk assessment tool was administered to 3,317 asymptomatic average risk patients 50 to 79 years of age just before their screening colonoscopy. Associations between YDR-derived relative risk (RR) scores and ACN prevalence were examined using logistic regression and χ(2) analyses. ACN was defined as a tubular adenoma ≥1 cm, tubulovillous or villous adenoma of any size, and the presence of high-grade dysplasia or cancer. The overall prevalence of ACN was 5.6%. Although YDR-derived RR scores were linearly associated with ACN after adjusting for age and gender (P = 0.033), the index was unable to discriminate "below average" from "above/average" risk patients [OR, 1.01; 95% confidence interval (CI), 0.75-1.37]. Considerable overlap in rates of ACN was also observed between the different YDR risk categories in our age- and gender-stratified analyses. The YDR index lacks accuracy for stratifying average risk patients into low- versus intermediate/high-risk categories for ACN.

  14. Advanced Prosthetic Gait Training Tool

    DTIC Science & Technology

    2014-10-01

    capture sequences was provided by MPL to CCAD and OGAL. CCAD’s work focused on imposing these sequences on the SantosTM digital human avatar . An...capture sequences was provided by MPL to CCAD and OGAL. CCAD’s work focused on imposing these sequences on the Santos digital human avatar . An initial...levels of the patients. In addition, the differences in ability to detect variations in gait conditions for skinned avatar vs. line-skeletal avatar

  15. Advanced Prosthetic Gait Training Tool

    DTIC Science & Technology

    2013-10-01

    or unclothed  avatars ,  stick figures, or even skeletal models to support their analyses. The system will also allow trainees to  isolate specific...CCAD’s work focused on imposing these sequences on the Santos digital  human  avatar . An initial user interface for the training application was also...ability to detect variations in gait conditions for  skinned  avatar  vs. line‐skeletal  avatar , concurrent (side‐by‐side) image representation vs

  16. ESO telbib: Linking In and Reaching Out

    NASA Astrophysics Data System (ADS)

    Grothkopf, U.; Meakins, S.

    2015-04-01

    Measuring an observatory's research output is an integral part of its science operations. Like many other observatories, ESO tracks scholarly papers that use observational data from ESO facilities and uses state-of-the-art tools to create, maintain, and further develop the Telescope Bibliography database (telbib). While telbib started out as a stand-alone tool mostly used to compile lists of papers, it has by now developed into a multi-faceted, interlinked system. The core of the telbib database is links between scientific papers and observational data generated by the La Silla Paranal Observatory residing in the ESO archive. This functionality has also been deployed for ALMA data. In addition, telbib reaches out to several other systems, including ESO press releases, the NASA ADS Abstract Service, databases at the CDS Strasbourg, and impact scores at Altmetric.com. We illustrate these features to show how the interconnected telbib system enhances the content of the database as well as the user experience.

  17. Cell electrospinning: a novel tool for functionalising fibres, scaffolds and membranes with living cells and other advanced materials for regenerative biology and medicine.

    PubMed

    Jayasinghe, Suwan N

    2013-04-21

    Recent years have seen interest in approaches for directly generating fibers and scaffolds following a rising trend for their exploration in the health sciences. In this review the author wishes to briefly highlight the many approaches explored to date for generating such structures, while underlining their advantages and disadvantages, and their contribution in particular to the biomedical sciences. Such structures have been demonstrated as having implications in both the laboratory and the clinic, as they mimic the native extra cellular matrix. Interestingly the only materials investigated until very recently for generating fibrous architectures employed either natural or synthetic polymers with or without the addition of functional molecule(s). Arguably although such constructs have been demonstrated to have many applications, they lack the one unit most important for carrying out the ability to directly reconstruct a three-dimensional functional tissue, namely living cells. Therefore recent findings have demonstrated the ability to directly form cell-laden fibers and scaffolds in useful quantities from which functional three-dimensional living tissues can be conceived. These recent developments have far-reaching ramifications to many areas of research and development, a few of which range from tissue engineering and regenerative medicine, a novel approach to analyzing cell behavior and function in real time in three-dimensions, to the advanced controlled and targeted delivery of experimental and/or medical cells and/or genes for localized treatment. At present these developments have passed all in vitro and in vivo mouse model based challenge trials and are now spearheading their journey towards initiating human clinical trials.

  18. Reaching for the red planet

    PubMed

    David, L

    1996-05-01

    The distant shores of Mars were reached by numerous U.S. and Russian spacecraft throughout the 1960s to mid 1970s. Nearly 20 years have passed since those successful missions which orbited and landed on the Martian surface. Two Soviet probes headed for the planet in July, 1988, but later failed. In August 1993, the U.S. Mars Observer suddenly went silent just three days before it was to enter orbit around the planet and was never heard from again. In late 1996, there will be renewed activity on the launch pads with three probes departing for the red planet: 1) The U.S. Mars Global Surveyor will be launched in November on a Delta II rocket and will orbit the planet for global mapping purposes; 2) Russia's Mars '96 mission, scheduled to fly in November on a Proton launcher, consists of an orbiter, two small stations which will land on the Martian surface, and two penetrators that will plow into the terrain; and finally, 3) a U.S. Discovery-class spacecraft, the Mars Pathfinder, has a December launch date atop a Delta II booster. The mission features a lander and a microrover that will travel short distances over Martian territory. These missions usher in a new phase of Mars exploration, setting the stage for an unprecedented volley of spacecraft that will orbit around, land on, drive across, and perhaps fly at low altitudes over the planet.

  19. FluxSuite: a New Scientific Tool for Advanced Network Management and Cross-Sharing of Next-Generation Flux Stations

    NASA Astrophysics Data System (ADS)

    Burba, G. G.; Johnson, D.; Velgersdyk, M.; Beaty, K.; Forgione, A.; Begashaw, I.; Allyn, D.

    2015-12-01

    Significant increases in data generation and computing power in recent years have greatly improved spatial and temporal flux data coverage on multiple scales, from a single station to continental flux networks. At the same time, operating budgets for flux teams and stations infrastructure are getting ever more difficult to acquire and sustain. With more stations and networks, larger data flows from each station, and smaller operating budgets, modern tools are needed to effectively and efficiently handle the entire process. This would help maximize time dedicated to answering research questions, and minimize time and expenses spent on data processing, quality control and station management. Cross-sharing the stations with external institutions may also help leverage available funding, increase scientific collaboration, and promote data analyses and publications. FluxSuite, a new advanced tool combining hardware, software and web-service, was developed to address these specific demands. It automates key stages of flux workflow, minimizes day-to-day site management, and modernizes the handling of data flows: Each next-generation station measures all parameters needed for flux computations Field microcomputer calculates final fully-corrected flux rates in real time, including computation-intensive Fourier transforms, spectra, co-spectra, multiple rotations, stationarity, footprint, etc. Final fluxes, radiation, weather and soil data are merged into a single quality-controlled file Multiple flux stations are linked into an automated time-synchronized network Flux network manager, or PI, can see all stations in real time, including fluxes, supporting data, automated reports, and email alerts PI can assign rights, allow or restrict access to stations and data: selected stations can be shared via rights-managed access internally or with external institutions Researchers without stations could form "virtual networks" for specific projects by collaborating with PIs from

  20. Application of metabolite profiling tools and time-of-flight mass spectrometry in the identification of transformation products of iopromide and iopamidol during advanced oxidation.

    PubMed

    Singh, Randolph R; Lester, Yaal; Linden, Karl G; Love, Nancy G; Atilla-Gokcumen, G Ekin; Aga, Diana S

    2015-03-03

    The efficiency of wastewater treatment systems in removing pharmaceuticals is often assessed on the basis of the decrease in the concentration of the parent compound. However, what is perceived as "removal" during treatment may not necessarily mean mineralization of the pharmaceutical compound but simply conversion into different transformation products (TPs). Using liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer (LC-QToF-MS), we demonstrated conversion of iopromide in wastewater to at least 14 TPs after an advanced oxidation process (AOP) using UV (fluence = 1500 mJ/cm(2)) and H2O2 (10 mg/L). Due to the complexity of the wastewater matrix, the initial experiments were performed using a high concentration (10 mg/L) of iopromide in order to facilitate the identification of TPs. Despite the high concentration of iopromide used, cursory inspection of UV and mass spectra only revealed four TPs in the chromatograms of the post-AOP samples. However, the use of METLIN database and statistics-based profiling tools commonly used in metabolomics proved effective in discriminating between background signals and TPs derived from iopromide. High-resolution mass data allowed one to predict molecular formulas of putative TPs with errors below 5 ppm relative to the observed m/z. Tandem mass spectrometry (MS/MS) data and isotope pattern comparisons provided necessary information that allowed one to elucidate the structure of iopromide TPs. The presence of the proposed iopromide TPs was determined in unspiked wastewater from a municipal wastewater treatment plant, but no iopromide and TPs were detected. Using analogous structural modifications and oxidation that results from the AOP treatment of iopromide, the potential TPs of iopamidol (a structurally similar compound to iopromide) were predicted. The same mass fragmentation pattern observed in iopromide TPs was applied to the predicted iopamidol TPs. LC-QToF-MS revealed the presence of two iopamidol

  1. Robotic-locomotor training as a tool to reduce neuromuscular abnormality in spinal cord injury: the application of system identification and advanced longitudinal modeling.

    PubMed

    Mirbagheri, Mehdi M; Kindig, Matthew; Niu, Xun; Varoqui, Deborah; Conaway, Petra

    2013-06-01

    In this study, the effect of the LOKOMAT, a robotic-assisted locomotor training system, on the reduction of neuromuscular abnormalities associated with spasticity was examined, for the first time in the spinal cord injury (SCI) population. Twenty-three individuals with chronic incomplete SCI received 1-hour training sessions in the LOKOMAT three times per week, with up to 45 minutes of training per session; matched control group received no intervention. The neuromuscular properties of the spastic ankle were then evaluated prior to training and after 1, 2, and 4 weeks of training. A parallel-cascade system identification technique was used to determine the reflex and intrinsic stiffness of the ankle joint as a function of ankle position at each time point. The slope of the stiffness vs. joint angle curve, i.e. the modulation of stiffness with joint position, was then calculated and tracked over the four-week period. Growth Mixture Modeling (GMM), an advanced statistical method, was then used to classify subjects into subgroups based on similar trends in recovery pattern of slope over time, and Random Coefficient Regression (RCR) was used to model the recovery patterns within each subgroup. All groups showed significant reductions in both reflex and intrinsic slope over time, but subjects in classes with higher baseline values of the slope showed larger improvements over the four weeks of training. These findings suggest that LOKOMAT training may also be useful for reducing the abnormal modulation of neuromuscular properties that arises as secondary effects after SCI. This can advise clinicians as to which patients can benefit the most from LOKOMAT training prior to beginning the training. Further, this study shows that system identification and GMM/RCR can serve as powerful tools to quantify and track spasticity over time in the SCI population.

  2. The Performance of Left-Handed Participants on a Preferential Reaching Test

    ERIC Educational Resources Information Center

    Mamolo, Carla M.; Roy, Eric A.; Bryden, Pamela J.; Rohr, Linda E.

    2005-01-01

    Previous research in our laboratory has examined the distribution of preferred hand (PH) reaches in working space with right-handed participants. In one study, we examined the effects of tool position and task demands on the frequency of PH reaches with right-handers (Mamolo, Roy, Bryden, & Rohr, 2004). We found that PH reaches were at a maximum…

  3. Proprioceptive Body Illusions Modulate the Visual Perception of Reaching Distance

    PubMed Central

    Petroni, Agustin; Carbajal, M. Julia; Sigman, Mariano

    2015-01-01

    The neurobiology of reaching has been extensively studied in human and non-human primates. However, the mechanisms that allow a subject to decide—without engaging in explicit action—whether an object is reachable are not fully understood. Some studies conclude that decisions near the reach limit depend on motor simulations of the reaching movement. Others have shown that the body schema plays a role in explicit and implicit distance estimation, especially after motor practice with a tool. In this study we evaluate the causal role of multisensory body representations in the perception of reachable space. We reasoned that if body schema is used to estimate reach, an illusion of the finger size induced by proprioceptive stimulation should propagate to the perception of reaching distances. To test this hypothesis we induced a proprioceptive illusion of extension or shrinkage of the right index finger while participants judged a series of LEDs as reachable or non-reachable without actual movement. Our results show that reach distance estimation depends on the illusory perceived size of the finger: illusory elongation produced a shift of reaching distance away from the body whereas illusory shrinkage produced the opposite effect. Combining these results with previous findings, we suggest that deciding if a target is reachable requires an integration of body inputs in high order multisensory parietal areas that engage in movement simulations through connections with frontal premotor areas. PMID:26110274

  4. Media perspective - new opportunities for reaching audiences

    NASA Astrophysics Data System (ADS)

    Haswell, Katy

    2007-08-01

    The world of media is experiencing a period of extreme and rapid change with the rise of internet television and the download generation. Many young people no longer watch standard TV. Instead, they go on-line, talking to friends and downloading pictures, videos, music clips to put on their own websites and watch/ listen to on their laptops and mobile phones. Gone are the days when TV controllers determined what you watched and when you watched it. Now the buzzword is IPTV, Internet Protocol Television, with companies such as JOOST offering hundreds of channels on a wide range of subjects, all of which you can choose to watch when and where you wish, on your high-def widescreen with stereo surround sound at home or on your mobile phone on the train. This media revolution is changing the way organisations get their message out. And it is encouraging companies such as advertising agencies to be creative about new ways of accessing audiences. The good news is that we have fresh opportunities to reach young people through internet-based media and material downloaded through tools such as games machines, as well as through the traditional media. And it is important for Europlanet to make the most of these new and exciting developments.

  5. Infants and adults reaching in the dark.

    PubMed

    Babinsky, Erin; Braddick, Oliver; Atkinson, Janette

    2012-03-01

    It has been shown that infants over the age of 6 months will reach for an object in complete darkness. This experiment measured the reaching movements of 9- to 16-month-old infants and adults under several different conditions of illumination to investigate the role of vision and stored visual representations in reach control. In one condition, participants reached for an object with the lights on. In a second condition, participants reached for an object glowing in the dark (glowing condition). This allowed us to measure the effects of vision of the arm and vision of the reach space. We also looked at the effect of removing vision of the object on reach control: in the final two conditions, participants reached for an object in complete darkness (0-s dark) and in complete darkness after a 4-s delay (4-s dark). We compared the kinematics of a reach (e.g. average speed, reach straightness) between the four illumination conditions. The results showed that infants reached faster and decelerated for a shorter period of time in the dark (0- and 4-s dark) than in the light. By comparison, adults reached slower and decelerated for a longer period of time in the dark (0- and 4-s dark) than in the light. We did not find any effect of the glowing condition compared to full vision on infant reaching movements. These results suggest that infant reaching movements only become compromised when the target is not visible, whereas vision of the hand and the reach space are less significant. Without online visual feedback, an infant reach in the dark appears to be driven by feedforward mechanisms and control may be affected by an immature ability to form and/or retain visual spatial memory.

  6. Education, Out-reach and In-reach Infrastructure Support for the Hydrologic Sciences

    NASA Astrophysics Data System (ADS)

    Hannigan, R.; McCaffrey, M.

    2002-05-01

    The Consortium of Universities for the Advancement of Hydrologic Science, incorporated (CUAHSI) is designed as an infrastructure support mechanism for research in the hydrologic sciences. Education, Out-reach and In-reach (EOI) is one of the five support thrusts of CUAHSI. EOI interfaces intimately with the other four thrusts (Hydrologic Science, Hydrologic Observatories, Hydrologic Information Systems, Hydrologic Measurement Technology). In addition, the EOI infrastructure will provide additional support to the scientific and educational communities as well as the general public. The EOI infrastructure aims to support scientists, educators, students and other interested parties through a variety of mechanisms including summer institutes, instrumentation training, student fellowships and institutional linkages. EOI's overall goal is to develop strategies, which have a broad impact and national significance. All EOI programs will link to CUAHSI science driven initiatives and will be evaluated in the basis of the impact of the program to the intended audience(s) and attainment of measurable outcomes. EOI, in addition to providing opportunities to the hydrologic science community, the broader scientific and education communities and the general public, will consistently interact with key members of pertinent communities to make them aware of available programs and to insure their participation by the interactive development of programs and opportunities. Potential activities include summer institutes at CUAHSI member universities for scientists, educators and students to exchange new ideas and learn new techniques. Potential exists for graduate student fellowships in support of research activities linked to CUAHSI science plans. Outreach to the general public and policy-makers may include distinguished speakers presenting general hydrologic science information and highlighting CUAHSI related research initiatives. In-reach is also a priority for EOI, and opportunities

  7. REACH: Real-Time Data Awareness in Multi-Spacecraft Missions

    NASA Technical Reports Server (NTRS)

    Maks, Lori; Coleman, Jason; Obenschain, Arthur F. (Technical Monitor)

    2002-01-01

    Missions have been proposed that will use multiple spacecraft to perform scientific or commercial tasks. Indeed, in the commercial world, some spacecraft constellations already exist. Aside from the technical challenges of constructing and flying these missions, there is also the financial challenge presented by the tradition model of the flight operations team (FOT) when it is applied to a constellation mission. Proposed constellation missions range in size from three spacecraft to more than 50. If the current ratio of three-to-five FOT personnel per spacecraft is maintained, the size of the FOT becomes cost prohibitive. The Advanced Architectures and Automation Branch at the Goddard Space Flight Center (GSFC Code 588) saw the potential to reduce the cost of these missions by creating new user interfaces to the ground system health-and-safety data. The goal is to enable a smaller FOT to remain aware and responsive to the increased amount of ground system information in a multi-spacecraft environment. Rather than abandon the tried and true, these interfaces were developed to run alongside existing ground system software to provide additional support to the FOT. These new user interfaces have been combined in a tool called REACH. REACH-the Real-time Evaluation and Analysis of Consolidated Health-is a software product that uses advanced visualization techniques to make spacecraft anomalies easy to spot, no matter how many spacecraft are in the constellation. REACH reads a real-time stream of data from the ground system and displays it to the FOT such that anomalies are easy to pick out and investigate. Data visualization has been used in ground system operations for many years. To provide a unique visualization tool, we developed a unique source of data to visualize: the REACH Health Model Engine. The Health Model Engine is rule-based software that receives real-time telemetry information and outputs "health" information related to the subsystems and spacecraft that

  8. REACH: impact on the US cosmetics industry?

    PubMed

    Pouillot, Anne; Polla, Barbara; Polla, Ada

    2009-03-01

    The Registration, Evaluation, Authorization and restriction of Chemicals (REACH) is a recent European regulation on chemical substances meant to protect human health and the environment. REACH imposes the "precautionary principle" where additional data and definitive action are required when uncertainty is identified. The cosmetics industry is only partially concerned by REACH: while the stages of registration and evaluation apply to cosmetics, those of authorization and restriction most likely will not, as cosmetic ingredients are already subject to regulation by various agencies and directives. REACH has potential benefits to the industry including the possibility of reassuring consumers and improving their image of chemicals and cosmetics. However, REACH also has potential disadvantages, mainly with regard to impeding innovation. The American cosmetics industry will be affected by REACH, because all US manufacturers who export substances to Europe will have to fully comply with REACH.

  9. A Meta-Analysis Method to Advance Design of Technology-Based Learning Tool: Combining Qualitative and Quantitative Research to Understand Learning in Relation to Different Technology Features

    ERIC Educational Resources Information Center

    Zhang, Lin

    2014-01-01

    Educators design and create various technology tools to scaffold students' learning. As more and more technology designs are incorporated into learning, growing attention has been paid to the study of technology-based learning tool. This paper discusses the emerging issues, such as how can learning effectiveness be understood in relation to…

  10. A New Method For Advanced Virtual Design Of Stamping Tools For Automotive Industry: Application To Nodular Cast Iron EN-GJS-600-3

    NASA Astrophysics Data System (ADS)

    Ben-Slima, Khalil; Penazzi, Luc; Mabru, Catherine; Ronde-Oustau, François; Rezaï-Aria, Farhad

    2011-05-01

    This contribution presents an approach combining the stamping numerical processing simulations and structure analysis in order to improve the design for optimizing the tool fatigue life. The method consists in simulating the stamping process via AutoForm® (or any FEM Code) by considering the tool as a perfect rigid body. The estimated contact pressure is then used as boundary condition for FEM structure loading analysis. The result of this analysis is used for life prediction of the tool using S-N fatigue curve. If the prescribed tool life requirements are not satisfied, then the critical region of the tool is redesigned and the whole simulation procedures are reactivated. This optimization method is applied for a cast iron EN-GJS-600-3 as candidate stamping tool materiel. The room temperature fatigue S-N curves of this alloy are established in laboratory under uniaxial push/pull cyclic experiments on cylindrical specimens under a load ratio of R (σmin/σmax) = -2.

  11. Anticipatory Postural Adjustments associated with reaching movements are programmed according to the availability of visual information.

    PubMed

    Esposti, Roberto; Bruttini, Carlo; Bolzoni, Francesco; Cavallari, Paolo

    2017-02-17

    During goal-directed arm movements, the eyes, head, and arm are coordinated to look at and reach the target. We examined whether the expectancy of visual information about the target modifies Anticipatory Postural Adjustments (APAs). Ten standing subjects had to (1) move the eyes, head and arm, so as to reach, with both gaze and index-finger, a target of known position placed outside their visual field (Gaze-Reach); (2) look at the target while reaching it (Reach in Full Vision); (3) keep the gaze away until having touched it (Reach then Gaze) and (4) just Gaze without Reach the target. We recorded eye, head, right arm, and acromion kinematics, EMGs from upper- and lower-limb muscles, and forces exerted on the ground. In Gaze-Reach, two coordination strategies were found: when gaze preceded arm muscle recruitment (Gaze-first) and when the opposite occurred (Reach-first). APAs in acromion kinematics, leg muscles, and ground forces started significantly earlier in Gaze-first vs. Reach-first (mean time advance: 44.3 ± 8.9 ms), as it was in Reach in Full Vision vs. Reach then Gaze (39.5 ± 7.9 ms). The Gaze-first to Reach-first time-shift was similar to that between Reach in Full Vision and Reach then Gaze (p = 0.58). Moreover, Gaze without Reach data witnessed that the head-induced postural actions did not affect the APA onset in Gaze-first and Reach-first. In conclusion, in Gaze-first, the central control of posture considers visual information while planning the movement, like in Reach in Full Vision; while Reach-first is more similar to Reach then Gaze, where vision is not required.

  12. Economic interpretation of environmental flow regime downstream diverted river reaches.

    NASA Astrophysics Data System (ADS)

    Gorla, Lorenzo; Perona, Paolo

    2013-04-01

    feasible and doesn't imply high costs or advanced management tools. Our approach is a simple but effective step towards eco-sustainability in the growing market of mini hydropower plants, where operation rules like MFR are still widespread. As such, this method is a powerful instrument for political managers to explicit contradictions thus enlightening best compromise measures/decisions. References Perona, P., Characklis, G., Duerrenmatt, D.J., in revision. Inverse parameters estimation of simple riparian benefit economical models. Journal of Environmental Management . Gorla, L. and Perona, P., in revision. On quantifying ecologically sustainable flow releases in a diverted river reach. Journal of Hydrology.

  13. Reach preparation enhances visual performance and appearance.

    PubMed

    Rolfs, Martin; Lawrence, Bonnie M; Carrasco, Marisa

    2013-10-19

    We investigated the impact of the preparation of reach movements on visual perception by simultaneously quantifying both an objective measure of visual sensitivity and the subjective experience of apparent contrast. Using a two-by-two alternative forced choice task, observers compared the orientation (clockwise or counterclockwise) and the contrast (higher or lower) of a Standard Gabor and a Test Gabor, the latter of which was presented during reach preparation, at the reach target location or the opposite location. Discrimination performance was better overall at the reach target than at the opposite location. Perceived contrast increased continuously at the target relative to the opposite location during reach preparation, that is, after the onset of the cue indicating the reach target. The finding that performance and appearance do not evolve in parallel during reach preparation points to a distinction with saccade preparation, for which we have shown previously there is a parallel temporal evolution of performance and appearance. Yet akin to saccade preparation, this study reveals that overall reach preparation enhances both visual performance and appearance.

  14. Teacher Evaluation in Practice: Year 3 Teacher and Administrator Perceptions of REACH. Research Brief

    ERIC Educational Resources Information Center

    Sporte, Susan E.; Jiang, Jennie Y.

    2016-01-01

    Three years after the launch of Chicago's redesigned teacher evaluation system, Recognizing Educators Advancing Chicago Students (REACH) Students, most teachers and administrators continue to report they believe REACH has the potential to improve instruction and student learning, and they remain negative about the use of student growth in…

  15. The database for reaching experiments and models.

    PubMed

    Walker, Ben; Kording, Konrad

    2013-01-01

    Reaching is one of the central experimental paradigms in the field of motor control, and many computational models of reaching have been published. While most of these models try to explain subject data (such as movement kinematics, reaching performance, forces, etc.) from only a single experiment, distinct experiments often share experimental conditions and record similar kinematics. This suggests that reaching models could be applied to (and falsified by) multiple experiments. However, using multiple datasets is difficult because experimental data formats vary widely. Standardizing data formats promises to enable scientists to test model predictions against many experiments and to compare experimental results across labs. Here we report on the development of a new resource available to scientists: a database of reaching called the Database for Reaching Experiments And Models (DREAM). DREAM collects both experimental datasets and models and facilitates their comparison by standardizing formats. The DREAM project promises to be useful for experimentalists who want to understand how their data relates to models, for modelers who want to test their theories, and for educators who want to help students better understand reaching experiments, models, and data analysis.

  16. Using Modern Solid-State Analytical Tools for Investigations of an Advanced Carbon Capture Material: Experiments for the Inorganic Chemistry Laboratory

    ERIC Educational Resources Information Center

    Wriedt, Mario; Sculley, Julian P.; Aulakh, Darpandeep; Zhou, Hong-Cai

    2016-01-01

    A simple and straightforward synthesis of an ultrastable porous metal-organic framework (MOF) based on copper(II) and a mixed N donor ligand system is described as a laboratory experiment for chemistry undergraduate students. These experiments and the resulting analysis are designed to teach students basic research tools and procedures while…

  17. NATIONAL URBAN DATABASE AND ACCESS PORTAL TOOL (NUDAPT): FACILITATING ADVANCEMENTS IN URBAN METEOROLOGY AND CLIMATE MODELING WITH COMMUNITY-BASED URBAN DATABASES

    EPA Science Inventory

    We discuss the initial design and application of the National Urban Database and Access Portal Tool (NUDAPT). This new project is sponsored by the USEPA and involves collaborations and contributions from many groups from federal and state agencies, and from private and academic i...

  18. Television Project to Reach the Handicapped Deaf.

    ERIC Educational Resources Information Center

    Hertzler, Ann A.; And Others

    1981-01-01

    Describes a project designed to use television public service announcements to present basic nutrition concepts and the nutritional choices in the marketplace in a format that would reach the handicapped deaf and the nonhandicapped as well. (CT)

  19. Reaching the Overlooked Student in Physical Education

    ERIC Educational Resources Information Center

    Esslinger, Keri; Esslinger, Travis; Bagshaw, Jarad

    2015-01-01

    This article describes the use of live action role-playing, or "LARPing," as a non-traditional activity that has the potential to reach students who are not interested in traditional physical education.

  20. Drug-induced sleep endoscopy as a selection tool for mandibular advancement therapy by oral device in patients with mild to moderate obstructive sleep apnoea.

    PubMed

    De Corso, E; Bastanza, G; Della Marca, G; Grippaudo, C; Rizzotto, G; Marchese, M R; Fiorita, A; Sergi, B; Meucci, D; Di Nardo, W; Paludetti, G; Scarano, E

    2015-12-01

    Nowadays oral appliance therapy is recognised as an effective therapy for many patients with primary snoring and mild to moderate obstructive sleep apnoea (OSA), as well as those with more severe OSA who cannot tolerate positive airway pressure (PAP) therapies. For this reason, it is important to focus on objective criteria to indicate which subjects may benefit from treatment with a mandibular advancement device (MAD). Various anthropometric and polysomnographic predictors have been described in the literature, whereas there are still controversies about the role of drug-induced sleep endoscopy (DISE) and advancement bimanual manoeuvre as predictor factors of treatment outcome by oral device. Herein, we report our experience in treatment of mild moderate OSA by oral appliance selected by DISE. We performed a single institution, longitudinal prospective evaluation of a consecutive group of mild moderate patients with obstructive sleep apnoea syndrome who underwent DISE. During sleep endoscopy, gentle manoeuvre of mandibular advancement less than 5 mm was performed. In 30 of 65 patients (46.2%) we obtained an unsuccessful improvement of airway patency whereas in 35 of 65 patients (53.8%) the improvement was successful and patients were considered suitable for oral device application. Because 7 of 35 patients were excluded due to conditions interfering with oral appliance therapy, we finally treated 28 patients. After 3 months of treatment, we observed a significant improvement in the Epworth medium index [(7.35 ± 2.8 versus 4.1 ± 2.2 (p < 0.05)], in mean AHI [(21.4 ± 6 events per hour versus 8.85 ± 6.9 (p < 0.05)] and in mean ODI [(18.6 ± 8 events per hour to 7 ± 5.8 (p < 0.05)]. We observed that the apnoea/hypopnoea index (AHI) improved by up to 50% from baseline in 71.4% of patients selected after DISE for MAD therapy. In the current study, mandibular advancement splint therapy was successfully prescribed on the basis not only of severity of disease, as

  1. Inhibitory control of reaching movements in humans.

    PubMed

    Mirabella, Giovanni; Pani, Pierpaolo; Paré, Martin; Ferraina, Stefano

    2006-09-01

    Behavioral flexibility provides a very large repertoire of actions and strategies, however, it carries a cost: a potential interference between different options. The voluntary control of behavior starts exactly with the ability of deciding between alternatives. Certainly inhibition plays a key role in this process. Here we examined the inhibitory control of reaching arm movements with the countermanding paradigm. Right-handed human subjects were asked to perform speeded reaching movements toward a visual target appearing either on the same or opposite side of the reaching arm (no-stop trials), but to withhold the commanded movement whenever an infrequent stop signal was presented (stop trials). As the delay between go and stop signals increased, subjects increasingly failed to inhibit the movement. From this inhibitory function and the reaction times of movements in no-stop trials, we estimated the otherwise unobservable duration of the stopping process, the stop signal reaction time (SSRT). We found that the SSRT for reaching movements was, on average, 206 ms and that it varied with the reaching arm and the target position even though the stop signal was a central stimulus. In fact, subjects were always faster to withhold reaching movements toward visual targets appearing on the same side of the reaching arm. This behavior strictly parallels the course of the reaction times of no-stop trials. These data show that the stop and go processes interacting in this countermanding task are independent, but most likely influenced by a common factor when under the control of the same hemisphere. In addition, we show that the point beyond which the response cannot be inhibited, the so-called point-of-no-return that divides controlled and ballistic phases of movement processing, lies after the inter-hemispheric transfer.

  2. JUST in time health emergency interventions: an innovative approach to training the citizen for emergency situations using virtual reality techniques and advanced IT tools (the Web-CD).

    PubMed

    Manganas, A; Tsiknakis, M; Leisch, E; Karefilaki, L; Monsieurs, K; Bossaert, L L; Giorgini, F

    2004-01-01

    This paper reports the results of the first of the two systems developed by JUST, a collaborative project supported by the European Union under the Information Society Technologies (IST) Programme. The most innovative content of the project has been the design and development of a complementary training course for non-professional health emergency operators, which supports the traditional learning phase, and which purports to improve the retention capability of the trainees. This was achieved with the use of advanced information technology techniques, which provide adequate support and can help to overcome the present weaknesses of the existing training mechanisms.

  3. What causes cooling water temperature gradients in forested stream reaches?

    NASA Astrophysics Data System (ADS)

    Garner, G.; Malcolm, I. A.; Sadler, J. P.; Hannah, D. M.

    2014-06-01

    upstream by >1h. Temperature gradients were not generated by cooling of stream water, but rather by a combination of reduced rates of heating in the woodland reach and advection of cooler (overnight and early morning) water from the upstream moorland catchment. Longitudinal thermal gradients were indistinct at night and on days when net radiation gains were low (under over-cast skies), thus when changes in net energy gains or losses did not vary significantly in space and time, and heat advected into the reach was reasonably consistent. The findings of the study and the modelling approach employed are useful tools for assessing optimal planting strategies for mitigating against ecologically damaging stream temperature maxima.

  4. How to Reach and Teach English Language Learners: Practical Strategies to Ensure Success

    ERIC Educational Resources Information Center

    Syrja, Rachel Carrillo

    2011-01-01

    This book provides practical strategies and tools for assessing and teaching even the most hard to reach English language learners across the content areas. Syrja offers educators the latest information on working with ELLs (including using formative assessments) and provides a wealth of classroom-tested models and measures. These tools have…

  5. Motion Plan Changes Predictably in Dyadic Reaching

    PubMed Central

    Burdet, Etienne

    2016-01-01

    Parents can effortlessly assist their child to walk, but the mechanism behind such physical coordination is still unknown. Studies have suggested that physical coordination is achieved by interacting humans who update their movement or motion plan in response to the partner’s behaviour. Here, we tested rigidly coupled pairs in a joint reaching task to observe such changes in the partners’ motion plans. However, the joint reaching movements were surprisingly consistent across different trials. A computational model that we developed demonstrated that the two partners had a distinct motion plan, which did not change with time. These results suggest that rigidly coupled pairs accomplish joint reaching movements by relying on a pre-programmed motion plan that is independent of the partner’s behaviour. PMID:27911938

  6. Lithographic measurement of EUV flare in the 0.3-NA Micro ExposureTool optic at the Advanced Light Source

    SciTech Connect

    Cain, Jason P.; Naulleau, Patrick; Spanos, Costas J.

    2005-01-01

    The level of flare present in a 0.3-NA EUV optic (the MET optic) at the Advanced Light Source at Lawrence Berkeley National Laboratory is measured using a lithographic method. Photoresist behavior at high exposure doses makes analysis difficult. Flare measurement analysis under scanning electron microscopy (SEM) and optical microscopy is compared, and optical microscopy is found to be a more reliable technique. In addition, the measured results are compared with predictions based on surface roughness measurement of the MET optical elements. When the fields in the exposure matrix are spaced far enough apart to avoid influence from surrounding fields and the data is corrected for imperfect mask contrast and aerial image proximity effects, the results match predicted values quite well. The amount of flare present in this optic ranges from 4.7% for 2 {micro}m features to 6.8% for 500 nm features.

  7. Cancer-related inflammation as predicting tool for treatment outcome in locally advanced and metastatic non-small cell lung cancer

    PubMed Central

    Korsic, Marta; Mursic, Davorka; Samarzija, Miroslav; Cucevic, Branka; Roglic, Mihovil; Jakopovic, Marko

    2016-01-01

    Background Lung cancer is the leading cause of cancer deaths and the non-small cell lung cancer (NSCLC) represents 80% of all cases. In most cases when diagnosed, it is in locally advanced or metastatic stage, when platinum based doublet chemotherapy is the established therapeutic option for majority of the patients. Predictive factors to filter the patients who will benefit the most from the chemotherapy are not clearly defined. Objective of this study was to explore predictive value of pre-treatment C-reactive protein (CRP), fibrinogen and their interaction, for the response to the frontline chemotherapy. Methods In this retrospective cohort study 170 patients with locally advanced and metastatic NSCLC were included. Relationship between baseline level of CRP and fibrinogen and response to the frontline chemotherapy was assessed. Results We found that pre-treatment CRP and fibrinogen values were statistically significantly correlated. Chemotherapy and CRP, fibrinogen, and their interaction were independently significantly associated with disease control rate at re-evaluation. There was statistically significant difference in median pre-treatment CRP level between the patients with disease control or progression at re-evaluation, 13.8 vs. 30.0 mg/L respectively, P=0.026. By Johnson-Neyman technique we found that in patients with initial fibrinogen value below 3.5 g/L, CRP level was significantly associated with disease control or progression of the disease. Above this fibrinogen value the association of CRP and disease control was lost. Conclusions The findings from this study support the growing evidence of inflammation and cancer relationship, where elevated pre-treatment level of CRP has negative predictive significance on the NSCLC frontline chemotherapy response. PMID:27499936

  8. Regional Arctic System Model (RASM): A Tool to Address the U.S. Priorities and Advance Capabilities for Arctic Climate Modeling and Prediction

    NASA Astrophysics Data System (ADS)

    Maslowski, W.; Roberts, A.; Cassano, J. J.; Gutowski, W. J., Jr.; Nijssen, B.; Osinski, R.; Zeng, X.; Brunke, M.; Duvivier, A.; Hamman, J.; Hossainzadeh, S.; Hughes, M.; Seefeldt, M. W.

    2015-12-01

    The Arctic is undergoing some of the most coordinated rapid climatic changes currently occurring anywhere on Earth, including the retreat of the perennial sea ice cover, which integrates forcing by, exchanges with and feedbacks between atmosphere, ocean and land. While historical reconstructions from Earth System Models (ESMs) are in broad agreement with these changes, the rate of change in ESMs generally remains outpaced by observations. Reasons for that relate to a combination of coarse resolution, inadequate parameterizations, under-represented processes and a limited knowledge of physical interactions. We demonstrate the capability of the Regional Arctic System Model (RASM) in addressing some of the ESM limitations in simulating observed variability and trends in arctic surface climate. RASM is a high resolution, pan-Arctic coupled climate model with the sea ice and ocean model components configured at an eddy-permitting resolution of 1/12o and the atmosphere and land hydrology model components at 50 km resolution, which are all coupled at 20-minute intervals. RASM is an example of limited-area, process-resolving, fully coupled ESM, which due to the constraints from boundary conditions facilitates detailed comparisons with observational statistics that are not possible with ESMs. The overall goal of RASM is to address key requirements published in the Navy Arctic Roadmap: 2014-2030 and in the Implementation Plan for the National Strategy for the Arctic Region, regarding the need for advanced modeling capabilities for operational forecasting and strategic climate predictions through 2030. The main science objectives of RASM are to advance understanding and model representation of critical physical processes and feedbacks of importance to sea ice thickness and area distribution. RASM results are presented to quantify relative contributions by (i) resolved processes and feedbacks as well as (ii) sensitivity to space dependent sub-grid parameterizations to better

  9. Reaching out: Beyond School Walls. Spotlight Feature

    ERIC Educational Resources Information Center

    Dopke-Wilson, MariRae

    2008-01-01

    In this article, the author features ideas and strategies for outreach that librarians can do to promote one's library media program and the good work it does. She stresses that by working together and reaching out, librarians can help foster visibility and support for school library media programs and professionals alike nationwide. Here, she…

  10. Reaching Rural Women: Case Studies and Strategies.

    ERIC Educational Resources Information Center

    Colle, Royal D.; Fernandez de Colle, Susana

    Although not often considered in the past by planners because their economic contributions are not performed for money, rural women are contributors to the development of their countries. The urgency of reaching women with important information to break the cycle of poverty is now being recognized by the major development agencies. While there are…

  11. Science Experiments: Reaching Out to Our Users

    ERIC Educational Resources Information Center

    Nolan, Maureen; Tschirhart, Lori; Wright, Stephanie; Barrett, Laura; Parsons, Matthew; Whang, Linda

    2008-01-01

    As more users access library services remotely, it has become increasingly important for librarians to reach out to their user communities and promote the value of libraries. Convincing the faculty and students in the sciences of the value of libraries and librarians can be a particularly "hard sell" as more and more of their primary…

  12. Pumpdown assistance extends coiled tubing reach

    SciTech Connect

    Tailby, R.J. )

    1992-07-01

    One of the most challenging coiled tubing applications to emerge in the last few years is horizontal well maintenance. When wireline cannot be used, techniques that offer some of the same flexibility, availability and relatively low cost must be used. During this same period, however, drilling technology has also made huge strides in horizontal and extended-reach areas. Wells are now being drilled with horizontal lengths in excess of 6,000 ft and measured depths of more than 22,000 ft. This paper reports that although horizontal wells are definitely here to stay, many operators have had to reevaluate their positions after being confronted with the problem of recompleting these wells to eliminate excessive water or gas production. A full workover with workstring using either a drilling rig or snubbing unit can be expensive and may lead to lost production because of limited rig availability. Coiled tubing has successfully been used in most cases thus far, but it has length and horizontal reach limitations that drilling technology will soon overtake. Within the constraints of current technology and tube capabilities, coiled tubing does not have the buckling resistance or reel capacity to service today's longest horizontal and extended reach wells or those planned and foreseen in the future. Even if coiled tubing can reach TD, operations requiring downward force are severely restricted.

  13. What Determines Limb Selection for Reaching?

    ERIC Educational Resources Information Center

    Helbig, Casi Rabb; Gabbard, Carl

    2004-01-01

    While motor dominance appears to drive limb selection for reaching movements at the midline and ipsilateral (dominant) side, this study examined the possible determinants associated with what drives the programming of movements in response to stimuli presented in contralateral space. Experiment 1 distinguished between object proximity and a…

  14. REACH. Teacher's Guide, Volume III. Task Analysis.

    ERIC Educational Resources Information Center

    Morris, James Lee; And Others

    Designed for use with individualized instructional units (CE 026 345-347, CE 026 349-351) in the electromechanical cluster, this third volume of the postsecondary teacher's guide presents the task analysis which was used in the development of the REACH (Refrigeration, Electro-Mechanical, Air Conditioning, Heating) curriculum. The major blocks of…

  15. A Rotation Invariant in 3-D Reaching

    ERIC Educational Resources Information Center

    Mitra, Suvobrata; Turvey, M. T.

    2004-01-01

    In 3 experiments, the authors investigated changes in hand orientation during a 3-D reaching task that imposed specific position and orientation requirements on the hand's initial and final postures. Instantaneous hand orientation was described using 3-element rotation vectors representing current orientation as a rotation from a fixed reference…

  16. REACH. Electricity Units, Post-Secondary.

    ERIC Educational Resources Information Center

    Smith, Gene; And Others

    As a part of the REACH (Refrigeration, Electro-Mechanical, Air-Conditioning, Heating) electromechanical cluster, this postsecondary student manual contains individualized instructional units in the area of electricity. The instructional units focus on electricity fundamentals, electric motors, electrical components, and controls and installation.…

  17. Goal-directed reaching: movement strategies influence the weighting of allocentric and egocentric visual cues.

    PubMed

    Neely, Kristina A; Tessmer, Ayla; Binsted, Gordon; Heath, Matthew

    2008-04-01

    The location of an object in peripersonal space can be represented with respect to our body (i.e., egocentric frame of reference) or relative to contextual features and other objects (i.e., allocentric frame of reference). In the current study, we sought to determine whether the frame, or frames, of visual reference supporting motor output is influenced by reach trajectories structured to maximize visual feedback utilization (i.e., controlled online) or structured largely in advance of movement onset via central planning mechanisms (i.e., controlled offline). Reaches were directed to a target embedded in a pictorial illusion (the induced Roelofs effect: IRE) and advanced knowledge of visual feedback was manipulated to influence the nature of reaching control as reported by Zelaznik et al. (J Mot Behav 15:217-236, 1983). When vision could not be predicted in advance of movement onset, trajectories showed primary evidence of an offline mode of control (even when vision was provided) and endpoints demonstrated amplified sensitivity to the illusory (i.e., allocentric) features of the IRE. In contrast, reaches performed with reliable visual feedback evidenced a primarily online mode of control and showed increased visuomotor resistance to the IRE. These findings suggest that the manner a reaching response is structured differentially influences the weighting of allocentric and egocentric visual information. More specifically, when visual feedback is unavailable or unpredictable, the weighting of allocentric visual information for the advanced planning of a reach trajectory is increased.

  18. An integrated approach to investigate the reach-averaged bend scale dynamics of large meandering rivers

    NASA Astrophysics Data System (ADS)

    Monegaglia, Federico; Henshaw, Alex; Zolezzi, Guido; Tubino, Marco

    2016-04-01

    Planform development of evolving meander bends is a beautiful and complex dynamic phenomenon, controlled by the interplay among hydrodynamics, sediments and floodplain characteristics. In the past decades, morphodynamic models of river meandering have provided a thorough understanding of the unit physical processes interacting at the reach scale during meander planform evolution. On the other hand, recent years have seen advances in satellite geosciences able to provide data with increasing resolution and earth coverage, which are becoming an important tool for studying and managing river systems. Analysis of the planform development of meandering rivers through Landsat satellite imagery have been provided in very recent works. Methodologies for the objective and automatic extraction of key river development metrics from multi-temporal satellite images have been proposed though often limited to the extraction of channel centerlines, and not always able to yield quantitative data on channel width, migration rates and bed morphology. Overcoming such gap would make a major step forward to integrate morphodynamic theories, models and real-world data for an increased understanding of meandering river dynamics. In order to fulfill such gaps, a novel automatic procedure for extracting and analyzing the topography and planform dynamics of meandering rivers through time from satellite images is implemented. A robust algorithm able to compute channel centerline in complex contexts such as the presence of channel bifurcations and anabranching structures is used. As a case study, the procedure is applied to the Landsat database for a reach of the well-known case of Rio Beni, a large, suspended load dominated, tropical meandering river flowing through the Bolivian Amazon Basin. The reach-averaged evolution of single bends along Rio Beni over a 30 years period is analyzed, in terms of bend amplification rates computed according to the local centerline migration rate. A

  19. Magnetospheric ULF wave studies in the frame of Swarm mission: new advanced tools for automated detection of pulsations in magnetic and electric field observations

    NASA Astrophysics Data System (ADS)

    Balasis, Georgios; Daglis, Ioannis A.; Papadimitriou, Constantinos; Georgiou, Marina; Giamini, Sigiava A.; Sandberg, Ingmar; Haagmans, Roger

    2014-05-01

    The rekindling of the interest in space science in the last 15 years has led to many successful satellite missions in the Earth's magnetosphere and topside ionosphere, which were able to provide the scientific community with high-quality data on the magnetic and electric fields surrounding our planet. This data pool will be further enriched by the measurements of ESA's Swarm mission, a constellation of three satellites in different polar orbits, flying at altitudes from 400 to 550 km, which was launched on the 22nd of November 2013. Aiming at the best scientific exploitation of this corpus of accumulated data, we have developed a set of analysis tools that can cope with measurements of various spacecraft, at various regions of the magnetosphere and in the topside ionosphere. Our algorithms are based on a combination of wavelet spectral methods and artificial neural network techniques and are suited for the detection of waves and wave-like disturbances as well as the extraction of several physical parameters. Our recent work demonstrates the applicability of our developed analysis tools, both for individual case studies and statistical analysis of ultra low frequency (ULF) waves. We provide evidence for a rare simultaneous observation of a ULF wave event in the Earth's magnetosphere, topside ionosphere and surface: we have found a specific time interval during the Halloween 2003 magnetic storm, when the Cluster and CHAMP spacecraft were in good local time (LT) conjunction, and have examined the ULF wave activity in the Pc3 (22-100 mHz), Pc4 (7-22 mHz) and Pc5 (1-7 mHz) bands using data from the Geotail, Cluster and CHAMP missions, as well as the CARISMA, GIMA and IMAGE magnetometer networks. Our study shows that the same wave event, characterized by increased activity in the high end of the Pc3 band, was simultaneously observed by all three satellite missions and by certain stations of ground networks. This observation provides a strong argument in favour of the

  20. The LandCarbon Web Application: Advanced Geospatial Data Delivery and Visualization Tools for Communication about Ecosystem Carbon Sequestration and Greenhouse Gas Fluxes

    NASA Astrophysics Data System (ADS)

    Thomas, N.; Galey, B.; Zhu, Z.; Sleeter, B. M.; Lehmer, E.

    2015-12-01

    The LandCarbon web application (http://landcarbon.org) is a collaboration between the U.S. Geological Survey and U.C. Berkeley's Geospatial Innovation Facility (GIF). The LandCarbon project is a national assessment focused on improved understanding of carbon sequestration and greenhouse gas fluxes in and out of ecosystems related to land use, using scientific capabilities from USGS and other organizations. The national assessment is conducted at a regional scale, covers all 50 states, and incorporates data from remote sensing, land change studies, aquatic and wetland data, hydrological and biogeochemical modeling, and wildfire mapping to estimate baseline and future potential carbon storage and greenhouse gas fluxes. The LandCarbon web application is a geospatial portal that allows for a sophisticated data delivery system as well as a suite of engaging tools that showcase the LandCarbon data using interactive web based maps and charts. The web application was designed to be flexible and accessible to meet the needs of a variety of users. Casual users can explore the input data and results of the assessment for a particular area of interest in an intuitive and interactive map, without the need for specialized software. Users can view and interact with maps, charts, and statistics that summarize the baseline and future potential carbon storage and fluxes for U.S. Level 2 Ecoregions for 3 IPCC emissions scenarios. The application allows users to access the primary data sources and assessment results for viewing and download, and also to learn more about the assessment's objectives, methods, and uncertainties through published reports and documentation. The LandCarbon web application is built on free and open source libraries including Django and D3. The GIF has developed the Django-Spillway package, which facilitates interactive visualization and serialization of complex geospatial raster data. The underlying LandCarbon data is available through an open application

  1. New advanced tools for combined ULF wave analysis of multipoint space-borne and ground observations: application to single event and statistical studies

    NASA Astrophysics Data System (ADS)

    Balasis, G.; Papadimitriou, C.; Daglis, I. A.; Georgiou, M.; Giamini, S. A.

    2013-12-01

    In the past decade, a critical mass of high-quality scientific data on the electric and magnetic fields in the Earth's magnetosphere and topside ionosphere has been progressively collected. This data pool will be further enriched by the measurements of the upcoming ESA/Swarm mission, a constellation of three satellites in three different polar orbits between 400 and 550 km altitude, which is expected to be launched in November 2013. New analysis tools that can cope with measurements of various spacecraft at various regions of the magnetosphere and in the topside ionosphere as well as ground stations will effectively enhance the scientific exploitation of the accumulated data. Here, we report on a new suite of algorithms based on a combination of wavelet spectral methods and artificial neural network techniques and demonstrate the applicability of our recently developed analysis tools both for individual case studies and statistical studies of ultra-low frequency (ULF) waves. First, we provide evidence for a rare simultaneous observation of a ULF wave event in the Earth's magnetosphere, topside ionosphere and surface: we have found a specific time interval during the Halloween 2003 magnetic storm, when the Cluster and CHAMP spacecraft were in good local time (LT) conjunction, and have examined the ULF wave activity in the Pc3 (22-100 mHz) and Pc4-5 (1-22 mHz) bands using data from the Geotail, Cluster and CHAMP missions, as well as the CARISMA and GIMA magnetometer networks. Then, we perform a statistical study of Pc3 wave events observed by CHAMP for the full decade (2001-2010) of the satellite vector magnetic data: the creation of a database of such events enabled us to derive valuable statistics for many important physical properties relating to the spatio-temporal location of these waves, the wave power and frequency, as well as other parameters and their correlation with solar wind conditions, magnetospheric indices, electron density data, ring current decay

  2. Development and Integration of an Advanced Stirling Convertor Linear Alternator Model for a Tool Simulating Convertor Performance and Creating Phasor Diagrams

    NASA Technical Reports Server (NTRS)

    Metscher, Jonathan F.; Lewandowski, Edward J.

    2013-01-01

    A simple model of the Advanced Stirling Convertors (ASC) linear alternator and an AC bus controller has been developed and combined with a previously developed thermodynamic model of the convertor for a more complete simulation and analysis of the system performance. The model was developed using Sage, a 1-D thermodynamic modeling program that now includes electro-magnetic components. The convertor, consisting of a free-piston Stirling engine combined with a linear alternator, has sufficiently sinusoidal steady-state behavior to allow for phasor analysis of the forces and voltages acting in the system. A MATLAB graphical user interface (GUI) has been developed to interface with the Sage software for simplified use of the ASC model, calculation of forces, and automated creation of phasor diagrams. The GUI allows the user to vary convertor parameters while fixing different input or output parameters and observe the effect on the phasor diagrams or system performance. The new ASC model and GUI help create a better understanding of the relationship between the electrical component voltages and mechanical forces. This allows better insight into the overall convertor dynamics and performance.

  3. Advancing representation of hydrologic processes in the Soil and Water Assessment Tool (SWAT) through integration of the TOPographic MODEL (TOPMODEL) features

    USGS Publications Warehouse

    Chen, J.; Wu, Y.

    2012-01-01

    This paper presents a study of the integration of the Soil and Water Assessment Tool (SWAT) model and the TOPographic MODEL (TOPMODEL) features for enhancing the physical representation of hydrologic processes. In SWAT, four hydrologic processes, which are surface runoff, baseflow, groundwater re-evaporation and deep aquifer percolation, are modeled by using a group of empirical equations. The empirical equations usually constrain the simulation capability of relevant processes. To replace these equations and to model the influences of topography and water table variation on streamflow generation, the TOPMODEL features are integrated into SWAT, and a new model, the so-called SWAT-TOP, is developed. In the new model, the process of deep aquifer percolation is removed, the concept of groundwater re-evaporation is refined, and the processes of surface runoff and baseflow are remodeled. Consequently, three parameters in SWAT are discarded, and two new parameters to reflect the TOPMODEL features are introduced. SWAT-TOP and SWAT are applied to the East River basin in South China, and the results reveal that, compared with SWAT, the new model can provide a more reasonable simulation of the hydrologic processes of surface runoff, groundwater re-evaporation, and baseflow. This study evidences that an established hydrologic model can be further improved by integrating the features of another model, which is a possible way to enhance our understanding of the workings of catchments.

  4. Advancing representation of hydrologic processes in the Soil and Water Assessment Tool (SWAT) through integration of the TOPographic MODEL (TOPMODEL) features

    NASA Astrophysics Data System (ADS)

    Chen, Ji; Wu, Yiping

    2012-02-01

    SummaryThis paper presents a study of the integration of the Soil and Water Assessment Tool (SWAT) model and the TOPographic MODEL (TOPMODEL) features for enhancing the physical representation of hydrologic processes. In SWAT, four hydrologic processes, which are surface runoff, baseflow, groundwater re-evaporation and deep aquifer percolation, are modeled by using a group of empirical equations. The empirical equations usually constrain the simulation capability of relevant processes. To replace these equations and to model the influences of topography and water table variation on streamflow generation, the TOPMODEL features are integrated into SWAT, and a new model, the so-called SWAT-TOP, is developed. In the new model, the process of deep aquifer percolation is removed, the concept of groundwater re-evaporation is refined, and the processes of surface runoff and baseflow are remodeled. Consequently, three parameters in SWAT are discarded, and two new parameters to reflect the TOPMODEL features are introduced. SWAT-TOP and SWAT are applied to the East River basin in South China, and the results reveal that, compared with SWAT, the new model can provide a more reasonable simulation of the hydrologic processes of surface runoff, groundwater re-evaporation, and baseflow. This study evidences that an established hydrologic model can be further improved by integrating the features of another model, which is a possible way to enhance our understanding of the workings of catchments.

  5. Olefins and chemical regulation in Europe: REACH.

    PubMed

    Penman, Mike; Banton, Marcy; Erler, Steffen; Moore, Nigel; Semmler, Klaus

    2015-11-05

    REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) is the European Union's chemical regulation for the management of risk to human health and the environment (European Chemicals Agency, 2006). This regulation entered into force in June 2007 and required manufacturers and importers to register substances produced in annual quantities of 1000 tonnes or more by December 2010, with further deadlines for lower tonnages in 2013 and 2018. Depending on the type of registration, required information included the substance's identification, the hazards of the substance, the potential exposure arising from the manufacture or import, the identified uses of the substance, and the operational conditions and risk management measures applied or recommended to downstream users. Among the content developed to support this information were Derived No-Effect Levels or Derived Minimal Effect Levels (DNELs/DMELs) for human health hazard assessment, Predicted No Effect Concentrations (PNECs) for environmental hazard assessment, and exposure scenarios for exposure and risk assessment. Once registered, substances may undergo evaluation by the European Chemicals Agency (ECHA) or Member State authorities and be subject to requests for additional information or testing as well as additional risk reduction measures. To manage the REACH registration and related activities for the European olefins and aromatics industry, the Lower Olefins and Aromatics REACH Consortium was formed in 2008 with administrative and technical support provided by Penman Consulting. A total of 135 substances are managed by this group including 26 individual chemical registrations (e.g. benzene, 1,3-butadiene) and 13 categories consisting of 5-26 substances. This presentation will describe the content of selected registrations prepared for 2010 in addition to the significant post-2010 activities. Beyond REACH, content of the registrations may also be relevant to other European activities, for

  6. Action Sounds Modulate Arm Reaching Movements

    PubMed Central

    Tajadura-Jiménez, Ana; Marquardt, Torsten; Swapp, David; Kitagawa, Norimichi; Bianchi-Berthouze, Nadia

    2016-01-01

    Our mental representations of our body are continuously updated through multisensory bodily feedback as we move and interact with our environment. Although it is often assumed that these internal models of body-representation are used to successfully act upon the environment, only a few studies have actually looked at how body-representation changes influence goal-directed actions, and none have looked at this in relation to body-representation changes induced by sound. The present work examines this question for the first time. Participants reached for a target object before and after adaptation periods during which the sounds produced by their hand tapping a surface were spatially manipulated to induce a representation of an elongated arm. After adaptation, participants’ reaching movements were performed in a way consistent with having a longer arm, in that their reaching velocities were reduced. These kinematic changes suggest auditory-driven recalibration of the somatosensory representation of the arm morphology. These results provide support to the hypothesis that one’s represented body size is used as a perceptual ruler to measure objects’ distances and to accordingly guide bodily actions. PMID:27695430

  7. Prison in-reach mental health nursing.

    PubMed

    Armitage, Claire; Fitzgerald, Carole; Cheong, Paula

    Surveys have shown that over 90 per cent of the prison population have a diagnosable mental illness, substance abuse problem, or both (ONS 1998). There is general agreement that although there are areas where practice is excellent, practice is not consistent across England and Wales, and often does not equate to standards in the NHS. In 2001 the Department of Health and the prison service set out their joint approach to the modernization of mental health services in prisons (DoH 2001), and proposed mental health in-reach as a means of improving services and achieving the objectives of the NHS Plan (DoH 2000). This article looks at the one of the first prison in-reach services that was launched at HMP Leicester early in 2002, and considers the effect these nurses have had on the care of mentally ill adults at the prison. A case study outlining the in-reach team's approach to one of the prison's greatest challenges, self-harm, is also included.

  8. Distance Reached in the Anteromedial Reach Test as a Function of Learning and Leg Length

    ERIC Educational Resources Information Center

    Bent, Nicholas P.; Rushton, Alison B.; Wright, Chris C.; Batt, Mark E.

    2012-01-01

    The Anteromedial Reach Test (ART) is a new outcome measure for assessing dynamic knee stability in anterior cruciate ligament-injured patients. The effect of learning and leg length on distance reached in the ART was examined. Thirty-two healthy volunteers performed 15 trials of the ART on each leg. There was a moderate correlation (r = 0.44-0.50)…

  9. Rotary earth boring tool

    SciTech Connect

    Dismukes, N.B.

    1983-09-27

    The present invention provides a nonstalling system for advancing a boring tool in situations where the inclination of the bore hole with respect to the vertical is such that the force of gravity does not provide effective forward thrust. A hydraulically powered marine screw propeller adjacent the boring tool provides the necessary thrust for the drilling operation. Pressurized drilling fluid provides the required hydraulic energy. The characteristics of the marine screw propeller are such that it provides maximum thrust at maximum rotative speed but should the tool stall the forward thrust drops to zero preventing stalling.

  10. The General Comments on HIV adopted by the African Commission on Human and Peoples' Rights as a tool to advance the sexual and reproductive rights of women in Africa.

    PubMed

    Durojaye, Ebenezer

    2014-12-01

    The present article examines the contents and importance of the General Comments adopted by the African Commission on Human and Peoples' Rights on Article 14 (1) (d) and (e) of the Protocol to the African Charter on the Rights of Women in Africa as a tool for advancing women's rights in the context of HIV. Given that discriminatory practices in all facets of life have continued to limit African women's enjoyment of their sexual and reproductive rights and render them susceptible to HIV infection, it becomes vital that African governments adopt appropriate measures to address this challenge. The provisions of the Protocol on the Rights of Women in Africa present great opportunities for this to be realized. The radical and progressive provisions of the Protocol will be of no use to women unless policymakers and other stakeholders have a clear understanding of them and are able to implement them effectively. The adoption of the General Comments is a welcome development, and states and civil society groups must maximize it to advance women's rights.

  11. A storm modeling system as an advanced tool in prediction of well organized slowly moving convective cloud system and early warning of severe weather risk

    NASA Astrophysics Data System (ADS)

    Spiridonov, Vlado; Curic, Mladjen

    2015-02-01

    Short-range prediction of precipitation is a critical input to flood prediction and hence the accuracy of flood warnings. Since most of the intensive processes come from convective clouds-the primary aim is to forecast these small-scale atmospheric processes. One characteristic pattern of organized group of convective clouds consist of a line of deep convection resulted in the repeated passage of heavy-rain-producing convective cells over NW part of Macedonia along the line. This slowly moving convective system produced extreme local rainfall and hailfall in urban Skopje city. A 3-d cloud model is used to simulate the main storm characteristic (e.g., structure, intensity, evolution) and the main physical processes responsible for initiation of heavy rainfall and hailfall. The model showed a good performance in producing significantly more realistic and spatially accurate forecasts of convective rainfall event than is possible with current operational system. The output results give a good initial input for developing appropriate tools such as flooding indices and potential risk mapping for interpreting and presenting the predictions so that they enhance operational flood prediction capabilities and warnings of severe weather risk of weather services. Convective scale model-even for a single case used has proved significant benefits in several aspects (initiation of convection, storm structure and evolution and precipitation). The storm-scale model (grid spacing-1 km) is capable of producing significantly more realistic and spatially accurate forecasts of convective rainfall events than is possible with current operational systems based on model with grid spacing 15 km.

  12. Molecular tools for chemical biotechnology

    PubMed Central

    Galanie, Stephanie; Siddiqui, Michael S.; Smolke, Christina D.

    2013-01-01

    Biotechnological production of high value chemical products increasingly involves engineering in vivo multi-enzyme pathways and host metabolism. Recent approaches to these engineering objectives have made use of molecular tools to advance de novo pathway identification, tunable enzyme expression, and rapid pathway construction. Molecular tools also enable optimization of single enzymes and entire genomes through diversity generation and screening, whole cell analytics, and synthetic metabolic control networks. In this review, we focus on advanced molecular tools and their applications to engineered pathways in host organisms, highlighting the degree to which each tool is generalizable. PMID:23528237

  13. A Survey of Reliability, Maintainability, Supportability, and Testability Software Tools

    DTIC Science & Technology

    1991-04-01

    5 1.101 Reliability Prediction Tools ......................... 6 1.102 Reliability Modeling Tools ........................... 14 1.103...M/S/T TOOL SUMMARIES 1.1 RELIABILITY TOOLS 1.101 Reliability Prediction Tools 1.102 Reliability Modeling Tools 1.103 Fault Tree Analysis Tools 1.104...Thermal Analysis Tools 1.115 Structural Reliability Evaluation Tools 5 1.101 RELIABILITY PREDICTION TOOLS NAME: ARM - Advanced Reliability Modeling

  14. Advancing computational methods for calibration of the Soil and Water Assessment Tool (SWAT): Application for modeling climate change impacts on water resources in the Upper Neuse Watershed of North Carolina

    NASA Astrophysics Data System (ADS)

    Ercan, Mehmet Bulent

    -Dominated Sorting Genetic Algorithm II (NSGA-II). This tool was demonstrated through an application for the Upper Neuse Watershed in North Carolina, USA. The objective functions used for the calibration were Nash-Sutcliffe (E) and Percent Bias (PB), and the objective sites were the Flat, Little, and Eno watershed outlets. The results show that the use of multi-objective calibration algorithms for SWAT calibration improved model performance especially in terms of minimizing PB compared to the single objective model calibration. The third study builds upon the first two studies by leveraging the new calibration methods and tools to study future climate impacts on the Upper Neuse watershed. Statistically downscaled outputs from eight Global Circulation Models (GCMs) were used for both low and high emission scenarios to drive a well calibrated SWAT model of the Upper Neuse watershed. The objective of the study was to understand the potential hydrologic response of the watershed, which serves as a public water supply for the growing Research Triangle Park region of North Carolina, under projected climate change scenarios. The future climate change scenarios, in general, indicate an increase in precipitation and temperature for the watershed in coming decades. The SWAT simulations using the future climate scenarios, in general, suggest an increase in soil water and water yield, and a decrease in evapotranspiration within the Upper Neuse watershed. In summary, this dissertation advances the field of watershed-scale hydrologic modeling by (i) providing some of the first work to apply cloud computing for the computationally-demanding task of model calibration; (ii) providing a new, open source library that can be used by SWAT modelers to perform multi-objective calibration of their models; and (iii) advancing understanding of climate change impacts on water resources for an important watershed in the Research Triangle Park region of North Carolina. The third study leveraged the

  15. Librarian Challenge: Reaching College Freshmen. Spotlight Feature

    ERIC Educational Resources Information Center

    Dopke-Wilson, MariRae

    2007-01-01

    Getting acclimated to campus life is overwhelming to most freshmen, making library orientation low on their priority list. The author teams up with two college librarians in action. Michael Pasqualoni, Instructional Services Librarian at Syracuse University Library, taught IST 200 last Fall. He relied on an arsenal of media tools to keep students…

  16. Perspective: Reaches of chemical physics in biology.

    PubMed

    Gruebele, Martin; Thirumalai, D

    2013-09-28

    Chemical physics as a discipline contributes many experimental tools, algorithms, and fundamental theoretical models that can be applied to biological problems. This is especially true now as the molecular level and the systems level descriptions begin to connect, and multi-scale approaches are being developed to solve cutting edge problems in biology. In some cases, the concepts and tools got their start in non-biological fields, and migrated over, such as the idea of glassy landscapes, fluorescence spectroscopy, or master equation approaches. In other cases, the tools were specifically developed with biological physics applications in mind, such as modeling of single molecule trajectories or super-resolution laser techniques. In this introduction to the special topic section on chemical physics of biological systems, we consider a wide range of contributions, all the way from the molecular level, to molecular assemblies, chemical physics of the cell, and finally systems-level approaches, based on the contributions to this special issue. Chemical physicists can look forward to an exciting future where computational tools, analytical models, and new instrumentation will push the boundaries of biological inquiry.

  17. Jetting tool

    SciTech Connect

    Szarka, D.D.; Schwegman, S.L.

    1991-07-09

    This patent describes an apparatus for hydraulically jetting a well tool disposed in a well, the well tool having a sliding member. It comprises positioner means for operably engaging the sliding member of the well tool; and a jetting means, connected at a rotatable connection to the positioner means so that the jetting means is rotatable relative to the positioner means and the well tool, for hydraulically jetting the well tool as the jetting means is rotated relative thereto.

  18. Riparian Vegetation Mapping Along the Hanford Reach

    SciTech Connect

    FOGWELL, T.W.

    2003-07-11

    During the biological survey and inventory of the Hanford Site conducted in the mid-1990s (1995 and 1996), preliminary surveys of the riparian vegetation were conducted along the Hanford Reach. These preliminary data were reported to The Nature Conservancy (TNC), but were not included in any TNC reports to DOE or stakeholders. During the latter part of FY2001, PNNL contracted with SEE Botanical, the parties that performed the original surveys in the mid 1990s, to complete the data summaries and mapping associated with the earlier survey data. Those data sets were delivered to PNNL and the riparian mapping by vegetation type for the Hanford Reach is being digitized during the first quarter of FY2002. These mapping efforts provide the information necessary to create subsequent spatial data layers to describe the riparian zone according to plant functional types (trees, shrubs, grasses, sedges, forbs). Quantification of the riparian zone by vegetation types is important to a number of DOE'S priority issues including modeling contaminant transport and uptake in the near-riverine environment and the determination of ecological risk. This work included the identification of vegetative zones along the Reach by changes in dominant plant species covering the shoreline from just to the north of the 300 Area to China Bar near Vernita. Dominant and indicator species included Agropyron dasytachyudA. smithii, Apocynum cannabinum, Aristida longiseta, Artemisia campestris ssp. borealis var scouleriana, Artemisa dracunculus, Artemisia lindleyana, Artemisia tridentata, Bromus tectorum, Chrysothamnus nauseosus, Coreopsis atkinsoniana. Eleocharis palustris, Elymus cinereus, Equisetum hyemale, Eriogonum compositum, Juniperus trichocarpa, Phalaris arundinacea, Poa compressa. Salk exigua, Scirpus acutus, Solidago occidentalis, Sporobolus asper,and Sporobolus cryptandrus. This letter report documents the data received, the processing by PNNL staff, and additional data gathered in FY2002

  19. Reaching for the Horizon: The 2015 NSAC Long Range Plan

    NASA Astrophysics Data System (ADS)

    Geesaman, Donald

    2015-10-01

    In April 2014, the Nuclear Science Advisory Committee was charged to conduct a new study of the opportunities and priorities for United States nuclear physics research and to recommend a long range plan for the coordinated advancement of the Nation's nuclear science program over the next decade. The entire community actively contributed to developing this plan. Ideas and goals, new and old, were examined and community priorities were established. The Long Range Plan Working Group gathered at Kitty Hawk, NC to converge on the recommendations. In this talk I will discuss the vision for the future that has emerged from this process. The new plan, ``Reaching for the Horizon,'' offers the promise of great leaps forward in our understanding of nuclear science and new opportunities for nuclear science to serve society. This work was supported by the U. S. Department of Energy, Office of Science, Office of Nuclear Physics, under Contract No. DE-AC02-06CH11357.

  20. NASA's Astronomy Education Program: Reaching Diverse Audiences

    NASA Astrophysics Data System (ADS)

    Hasan, Hashima; Smith, Denise Anne; Hertz, Paul; Meinke, Bonnie

    2015-08-01

    An overview will be given of the rich programs developed by NASA to inject the science from it's Astrophysics missions into STEM activities targeted to diverse audiences. For example, Astro4Girls was started as a pilot program during IYA2009. This program partners NASA astrophysics education programs with public libraries to provide NASA-themed hands-on education activities for girls and their families, and has been executed across the country. School curricula and NASA websites have been translated in Spanish; Braille books have been developed for the visually impaired; programs have been developed for the hearing impaired. Special effort has been made to reach underrepresented minorities. Audiences include students, teachers, and the general public through formal and informal education settings, social media and other outlets. NASA Astrophysics education providers include teams embedded in its space flight missions; professionals selected though peer reviewed programs; as well as the Science Mission Directorate Astrophysics Education forum. Representative examples will be presented to demonstrate the reach of NASA education programs, as well as an evaluation of the effectiveness of these programs.

  1. Mass reach scaling for future hadron colliders

    NASA Astrophysics Data System (ADS)

    Rizzo, Thomas G.

    2015-04-01

    The primary goal of any future hadron collider is to discover new physics (NP) associated with a high mass scale, , beyond the range of the LHC. In order to maintain the same relative mass reach for rate-limited NP, , as increases, Richter recently reminded us that the required integrated luminosity obtainable at future hadron colliders (FHC) must grow rapidly, , in the limit of naive scaling. This would imply, e.g., a 50-fold increase in the required integrated luminosity when going from the 14 TeV LHC to a FHC with TeV, an increase that would prove quite challenging on many different fronts. In this paper we point out, due to the scaling violations associated with the evolution of the parton density functions (PDFs) and the running of the strong coupling, , that the actual luminosity necessary in order to maintain any fixed value of the relative mass reach is somewhat greater than this scaling result indicates. However, the actual values of the required luminosity scaling are found to be dependent upon the detailed nature of the NP being considered. Here we elucidate this point explicitly by employing several specific benchmark examples of possible NP scenarios and briefly discuss the (relatively weak) search impact in each case if these luminosity goals are not met.

  2. Can donated media placements reach intended audiences?

    PubMed

    Cooper, Crystale Purvis; Gelb, Cynthia A; Chu, Jennifer; Polonec, Lindsey

    2013-09-01

    Donated media placements for public service announcements (PSAs) can be difficult to secure, and may not always reach intended audiences. Strategies used by the Centers for Disease Control and Prevention's (CDC) Screen for Life: National Colorectal Cancer Action Campaign (SFL) to obtain donated media placements include producing a diverse mix of high-quality PSAs, co-branding with state and tribal health agencies, securing celebrity involvement, monitoring media trends to identify new distribution opportunities, and strategically timing the release of PSAs. To investigate open-ended recall of PSAs promoting colorectal cancer screening, CDC conducted 12 focus groups in three U.S. cities with men and women either nearing age 50 years, when screening is recommended to begin, or aged 50-75 years who were not in compliance with screening guidelines. In most focus groups, multiple participants recalled exposure to PSAs promoting colorectal cancer screening, and most of these individuals reported having seen SFL PSAs on television, in transit stations, or on the sides of public buses. Some participants reported exposure to SFL PSAs without prompting from the moderator, as they explained how they learned about the disease. Several participants reported learning key campaign messages from PSAs, including that colorectal cancer screening should begin at age 50 years and screening can find polyps so they can be removed before becoming cancerous. Donated media placements can reach and educate mass audiences, including millions of U.S. adults who have not been screened appropriately for colorectal cancer.

  3. [Risk assessment and chemical safety under REACH].

    PubMed

    Foth, Heidi

    2008-12-01

    Under the new European chemical legislation REACH (EG 1907/2006), dangerous properties of chemical substances will be evaluated and data gaps will be closed. This information is needed for other regulations, such as safety at the working place or for the safe handling of products. Existing knowledge on chemical compounds must be broadened because previous regulations have focused on high production volume compounds. The evaluation procedures needed too much time, and for the majority of non-evaluated substances a new strategy is needed. REACH places the duty for registration of substances with the producers and importers. Data gaps for risk evaluation will be closed. Competent authorities will be relieved from the primary risk evaluation of most substances. Alternative strategies of evaluation using previous information and non-animal testing approaches will be supported to avoid animal testing where appropriate. The new European chemical agency ECHA will use the provided information in order to identify very dangerous chemical substances which should be controlled by authorization of its use and the circumstances thereof.

  4. Napa River Restoration Project: Rutherford Reach Completion and Oakville to Oak Knoll Reach

    EPA Pesticide Factsheets

    Information about the SFBWQP Napa River Restoration Project: Rutherford Reach Completion/Oakville to Oak Knoll, part of an EPA competitive grant program to improve SF Bay water quality focused on restoring impaired waters and enhancing aquatic resources.

  5. Addressing challenges and needs in patient education targeting hardly reached patients with chronic diseases.

    PubMed

    Varming, Annemarie Reinhardt; Torenholt, Rikke; Møller, Birgitte Lund; Vestergaard, Susanne; Engelund, Gitte

    2015-01-01

    Some patients do not benefit from participation in patient education due to reasons related to disease burden, literacy, and socioeconomic challenges. In this communication, we address more specifically both the challenges that these hardly reached patients face in relation to patient education programs and the challenges educators face when conducting patient education with hardly reached patients. We define principles for the format and content of dialogue tools to better support this patient group within the population of individuals with diabetes.

  6. Addressing challenges and needs in patient education targeting hardly reached patients with chronic diseases

    PubMed Central

    Varming, Annemarie Reinhardt; Torenholt, Rikke; Møller, Birgitte Lund; Vestergaard, Susanne; Engelund, Gitte

    2015-01-01

    Some patients do not benefit from participation in patient education due to reasons related to disease burden, literacy, and socioeconomic challenges. In this communication, we address more specifically both the challenges that these hardly reached patients face in relation to patient education programs and the challenges educators face when conducting patient education with hardly reached patients. We define principles for the format and content of dialogue tools to better support this patient group within the population of individuals with diabetes. PMID:25729695

  7. Evaluation of a hydrological model based on Bidirectional Reach (BReach)

    NASA Astrophysics Data System (ADS)

    Van Eerdenbrugh, Katrien; Van Hoey, Stijn; Verhoest, Niko E. C.

    2016-04-01

    Evaluation and discrimination of model structures is crucial to ensure an appropriate use of hydrological models. When evaluating model results by aggregating their quality in (a subset of) individual observations, overall results of this analysis sometimes conceal important detailed information about model structural deficiencies. Analyzing model results within their local (time) context can uncover this detailed information. In this research, a methodology called Bidirectional Reach (BReach) is proposed to evaluate and analyze results of a hydrological model by assessing the maximum left and right reach in each observation point that is used for model evaluation. These maximum reaches express the capability of the model to describe a subset of the evaluation data both in the direction of the previous (left) and of the following data (right). This capability is evaluated on two levels. First, on the level of individual observations, the combination of a parameter set and an observation is classified as non-acceptable if the deviation between the accompanying model result and the measurement exceeds observational uncertainty. Second, the behavior in a sequence of observations is evaluated by means of a tolerance degree. This tolerance degree expresses the condition for satisfactory model behavior in a data series and is defined by the percentage of observations within this series that can have non-acceptable model results. Based on both criteria, the maximum left and right reaches of a model in an observation represent the data points in the direction of the previous respectively the following observations beyond which none of the sampled parameter sets both are satisfactory and result in an acceptable deviation. After assessing these reaches for a variety of tolerance degrees, results can be plotted in a combined BReach plot that show temporal changes in the behavior of model results. The methodology is applied on a Probability Distributed Model (PDM) of the river

  8. Advances in retinal ganglion cell imaging

    PubMed Central

    Balendra, S I; Normando, E M; Bloom, P A; Cordeiro, M F

    2015-01-01

    Glaucoma is one of the leading causes of blindness worldwide and will affect 79.6 million people worldwide by 2020. It is caused by the progressive loss of retinal ganglion cells (RGCs), predominantly via apoptosis, within the retinal nerve fibre layer and the corresponding loss of axons of the optic nerve head. One of its most devastating features is its late diagnosis and the resulting irreversible visual loss that is often predictable. Current diagnostic tools require significant RGC or functional visual field loss before the threshold for detection of glaucoma may be reached. To propel the efficacy of therapeutics in glaucoma, an earlier diagnostic tool is required. Recent advances in retinal imaging, including optical coherence tomography, confocal scanning laser ophthalmoscopy, and adaptive optics, have propelled both glaucoma research and clinical diagnostics and therapeutics. However, an ideal imaging technique to diagnose and monitor glaucoma would image RGCs non-invasively with high specificity and sensitivity in vivo. It may confirm the presence of healthy RGCs, such as in transgenic models or retrograde labelling, or detect subtle changes in the number of unhealthy or apoptotic RGCs, such as detection of apoptosing retinal cells (DARC). Although many of these advances have not yet been introduced to the clinical arena, their successes in animal studies are enthralling. This review will illustrate the challenges of imaging RGCs, the main retinal imaging modalities, the in vivo techniques to augment these as specific RGC-imaging tools and their potential for translation to the glaucoma clinic. PMID:26293138

  9. Image-Capture Devices Extend Medicine's Reach

    NASA Technical Reports Server (NTRS)

    2009-01-01

    Johnson Space Center, Henry Ford Hospital in Detroit, and Houston-based Wyle Laboratories collaborated on NASA's Advanced Diagnostic Ultrasound in Microgravity (ADUM) experiment, which developed revolutionary medical ultrasound diagnostic techniques for long-distance use. Mediphan, a Canadian company with U.S. operations in Springfield, New Jersey drew on NASA expertise to create frame-grabber and data archiving technology that enables ultrasound users with minimal training to send diagnostic-quality ultrasound images and video to medical professionals via the Internet in near real time allowing patients as varied as professional athletes, Olympians, and mountain climbers to receive medical attention as soon as it is needed.

  10. A model for learning human reaching movements.

    PubMed

    Karniel, A; Inbar, G F

    1997-09-01

    Reaching movement is a fast movement towards a given target. The main characteristics of such a movement are straight path and a bell-shaped speed profile. In this work a mathematical model for the control of the human arm during ballistic reaching movements is presented. The model of the arm contains a 2 degrees of freedom planar manipulator, and a Hill-type, non-linear mechanical model of six muscles. The arm model is taken from the literature with minor changes. The nervous system is modeled as an adjustable pattern generator that creates the control signals to the muscles. The control signals in this model are rectangular pulses activated at various amplitudes and timings, that are determined according to the given target. These amplitudes and timings are the parameters that should be related to each target and initial conditions in the work-space. The model of the nervous system consists of an artificial neural net that maps any given target to the parameter space of the pattern generator. In order to train this net, the nervous system model includes a sensitivity model that transforms the error from the arm end-point coordinates to the parameter coordinates. The error is assessed only at the termination of the movement from knowledge of the results. The role of the non-linearity in the muscle model and the performance of the learning scheme are analysed, illustrated in simulations and discussed. The results of the present study demonstrate the central nervous system's (CNS) ability to generate typical reaching movements with a simple feedforward controller that controls only the timing and amplitude of rectangular excitation pulses to the muscles and adjusts these parameters based on knowledge of the results. In this scheme, which is based on the adjustment of only a few parameters instead of the whole trajectory, the dimension of the control problem is reduced significantly. It is shown that the non-linear properties of the muscles are essential to achieve

  11. Reach and get capability in a computing environment

    DOEpatents

    Bouchard, Ann M [Albuquerque, NM; Osbourn, Gordon C [Albuquerque, NM

    2012-06-05

    A reach and get technique includes invoking a reach command from a reach location within a computing environment. A user can then navigate to an object within the computing environment and invoke a get command on the object. In response to invoking the get command, the computing environment is automatically navigated back to the reach location and the object copied into the reach location.

  12. Integrated testing strategy (ITS) for bioaccumulation assessment under REACH.

    PubMed

    Lombardo, Anna; Roncaglioni, Alessandra; Benfentati, Emilio; Nendza, Monika; Segner, Helmut; Fernández, Alberto; Kühne, Ralph; Franco, Antonio; Pauné, Eduard; Schüürmann, Gerrit

    2014-08-01

    REACH (registration, evaluation, authorisation and restriction of chemicals) regulation requires that all the chemicals produced or imported in Europe above 1 tonne/year are registered. To register a chemical, physicochemical, toxicological and ecotoxicological information needs to be reported in a dossier. REACH promotes the use of alternative methods to replace, refine and reduce the use of animal (eco)toxicity testing. Within the EU OSIRIS project, integrated testing strategies (ITSs) have been developed for the rational use of non-animal testing approaches in chemical hazard assessment. Here we present an ITS for evaluating the bioaccumulation potential of organic chemicals. The scheme includes the use of all available data (also the non-optimal ones), waiving schemes, analysis of physicochemical properties related to the end point and alternative methods (both in silico and in vitro). In vivo methods are used only as last resort. Using the ITS, in vivo testing could be waived for about 67% of the examined compounds, but bioaccumulation potential could be estimated on the basis of non-animal methods. The presented ITS is freely available through a web tool.

  13. Reaching Consensus by Allowing Moments of Indecision

    NASA Astrophysics Data System (ADS)

    Svenkeson, A.; Swami, A.

    2015-10-01

    Group decision-making processes often turn into a drawn out and costly battle between two opposing subgroups. Using analytical arguments based on a master equation description of the opinion dynamics occurring in a three-state model of cooperatively interacting units, we show how the capability of a social group to reach consensus can be enhanced when there is an intermediate state for indecisive individuals to pass through. The time spent in the intermediate state must be relatively short compared to that of the two polar states in order to create the beneficial effect. Furthermore, the cooperation between individuals must not be too low, as the benefit to consensus is possible only when the cooperation level exceeds a specific threshold. We also discuss how zealots, agents that remain in one state forever, can affect the consensus among the rest of the population by counteracting the benefit of the intermediate state or making it virtually impossible for an opposition to form.

  14. Reaching Consensus by Allowing Moments of Indecision

    PubMed Central

    Svenkeson, A.; Swami, A.

    2015-01-01

    Group decision-making processes often turn into a drawn out and costly battle between two opposing subgroups. Using analytical arguments based on a master equation description of the opinion dynamics occurring in a three-state model of cooperatively interacting units, we show how the capability of a social group to reach consensus can be enhanced when there is an intermediate state for indecisive individuals to pass through. The time spent in the intermediate state must be relatively short compared to that of the two polar states in order to create the beneficial effect. Furthermore, the cooperation between individuals must not be too low, as the benefit to consensus is possible only when the cooperation level exceeds a specific threshold. We also discuss how zealots, agents that remain in one state forever, can affect the consensus among the rest of the population by counteracting the benefit of the intermediate state or making it virtually impossible for an opposition to form. PMID:26439503

  15. Tool Carrier

    NASA Technical Reports Server (NTRS)

    1980-01-01

    Tool organizer accommodates a selection of hand tools on a waist or thigh belt or alternately on wall, work bench, or car trunk mountings. Tool caddy is widely used by industrial maintenance personnel, TV technicians, mechanics, artists, draftsmen, hobbyists and homeowners. Its innovative feature is rows of flexible vinyl "fingers" like the bristles of a hairbrush which mesh together to hold the tool securely in place yet allow easy insertion or withdrawal. Product is no longer commercially available.

  16. Percussion tool

    DOEpatents

    Reed, Teddy R.

    2006-11-28

    A percussion tool is described and which includes a housing mounting a tool bit; a reciprocally moveable hammer borne by the housing and which is operable to repeatedly strike the tool bit; and a reciprocally moveable piston enclosed within the hammer and which imparts reciprocal movement to the reciprocally moveable hammer.

  17. Reference condition of river reaches for restoration: Oiartzun and Oria basins (Gipuzkoa)

    NASA Astrophysics Data System (ADS)

    Ibisate, Askoa; Ollero, Alfredo; Sáenz de Olazagoitia, Ana; Acín, Vanesa; Granado, David; Ballarín, Daniel; Herrero, Xabier; Horacio, Jesús; Mora, Daniel

    2016-04-01

    The development and application of a methodology for the identification of the morphological reference condition and target image for river restoration is presented. The methodology started with the identification of the geomorphological homogeneous river reaches. Two reach-making processes were developed; one based on crossed variables by GIS tools and a second more exhaustive, basin level and based on fieldwork data. Based on data the hydrogeomorphological status of each reach in relation to its "natural" condition has been assessed. This assessment was used to allocate each reach to another with a good or very good hydrogeomorphological condition which it was considered its reference condition. Finally target images were proposed for each reach, as well as feasible geomorphological restoration measures, taking into account the sociodemographical pressure that implies most of the hydromorphological pressures and impacts, and the active channel evolution and land use changes on the basin.

  18. Sequential tool use in great apes.

    PubMed

    Martin-Ordas, Gema; Schumacher, Lena; Call, Josep

    2012-01-01

    Sequential tool use is defined as using a tool to obtain another non-food object which subsequently itself will serve as a tool to act upon a further (sub)goal. Previous studies have shown that birds and great apes succeed in such tasks. However, the inclusion of a training phase for each of the sequential steps and the low cost associated with retrieving the longest tools limits the scope of the conclusions. The goal of the experiments presented here was, first to replicate a previous study on sequential tool use conducted on New Caledonian crows and, second, extend this work by increasing the cost of retrieving a tool in order to test tool selectivity of apes. In Experiment 1, we presented chimpanzees, orangutans and bonobos with an out-of-reach reward, two tools that were available but too short to reach the food and four out-of-reach tools differing in functionality. Similar to crows, apes spontaneously used up to 3 tools in sequence to get the reward and also showed a strong preference for the longest out-of reach tool independently of the distance of the food. In Experiment 2, we increased the cost of reaching for the longest out-of reach tool. Now apes used up to 5 tools in sequence to get the reward and became more selective in their choice of the longest tool as the costs of its retrieval increased. The findings of the studies presented here contribute to the growing body of comparative research on tool use.

  19. PV Hourly Simulation Tool

    SciTech Connect

    Dean, Jesse; Metzger, Ian

    2010-12-31

    This software requires inputs of simple general building characteristics and usage information to calculate the energy and cost benefits of solar PV. This tool conducts and complex hourly simulation of solar PV based primarily on the area available on the rooftop. It uses a simplified efficiency calculation method and real panel characteristics. It includes a detailed rate structure to account for time-of-use rates, on-peak and off-peak pricing, and multiple rate seasons. This tool includes the option for advanced system design inputs if they are known. This tool calculates energy savings, demand reduction, cost savings, incentives and building life cycle costs including: simple payback, discounted payback, net-present value, and savings to investment ratio. In addition this tool also displays the environmental benefits of a project.

  20. The chemical and environmental property space of REACH chemicals.

    PubMed

    Öberg, Tomas; Iqbal, M Sarfraz

    2012-05-01

    The European regulation on chemicals, REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals), came into force on 1 June 2007. With pre-registration complete in 2008, data for these substances may provide an overview of the expected chemical space and its characteristics. In this paper, using various in silico computation tools, we evaluate 48782 neutral organic compounds from the list to identify hazardous and safe compounds. Two different classification schemes (modified Verhaar and ECOSAR) identified between 17% and 25% of the compounds as expressing only baseline toxicity (narcosis). A smaller portion could be identified as reactive (19%) or specifically acting (2.7%), while the majority were non-assigned (61%). Overall environmental persistence, bioaccumulation and long-range transport potential were evaluated using structure-activity relationships and a multimedia fugacity-based model. A surprisingly high proportion of compounds (20%), mainly aromatic and halogenated, had a very high estimated persistence (>195 d). The proportion of compounds with a very high estimated bioconcentration or bioaccumulation factor (>5000) was substantially less (6.9%). Finally, a list was compiled of those compounds within the applicability domain of the models used, meeting both persistence and bioaccumulation criteria, and with a long-range transport potential comparable to PCB. This list of 68 potential persistent organic pollutants contained many well-known compounds (all halogenated), but notably also five fluorinated compounds that were not included in the EINECS inventory. This study demonstrates the usability of in silico tools for identification of potentially environmentally hazardous chemicals.

  1. Poleward reach of the California Undercurrent extension

    NASA Astrophysics Data System (ADS)

    Thomson, Richard E.; Krassovski, Maxim V.

    2010-09-01

    The California Undercurrent is known to transport relatively warm, high-salinity, nutrient-rich water from the equatorial Pacific to Vancouver Island along the western continental slope of North America. This transport helps maintain the high productivity of the eastern boundary California Current system. In this study, we use several decades of water property survey data for the coasts of Oregon, Washington, British Columbia, and Alaska to show that equatorial Pacific water carried poleward by the undercurrent can eventually reach the Aleutian Islands, roughly 11,000 km from the source region. Long-term current meter records confirm the undercurrent as far north as Vancouver Island, where the current is found to be weakest in spring but then to strengthen through the summer and fall before merging with the wind-forced, poleward flowing Davidson Current in winter. The core depth of the equatorial water increases from 150 m ± 25 m off northwest Washington (near the northern end of the western North America coastal upwelling domain) to 225 m ± 25 m off southeast Alaska (near the southern end of the Gulf of Alaska coastal downwelling domain).

  2. Reaching the Next Generation of Marine Scientists

    NASA Astrophysics Data System (ADS)

    Joyce, J.

    2009-04-01

    The next generation of marine scientists are today at primary school, secondary school or at college. To encourage them in their career, and to introduce those who are as yet undecided to the wonders of marine science, the Irish Marine Institute has devised a series of three overlapping outreach programmes to reach children at all three levels. Beginning at primary school, the "Explorers" programme offers a range of resources to teachers to enable them to teach marine-related examples as part of the science or geography modules of the SESE curriculum. These include teacher training, expert visits to schools, the installation and stocking of aquaria, field trips and downloadable lesson plans. For older pupils, the "Follow the Fleet" programme is a web-based education asset that allows users to track individual merchant ships and research vessels across the world, to interact with senior crew members of ships and to learn about their cargoes, the ports they visit and the sea conditions along the way. Finally, the "Integrated Marine Exploration Programme (IMEP)" takes secondary school pupils and university students to sea aboard the Marine Institute's research vessels to give them a taste of life as a marine scientist or to educate them in the practical day-to-day sampling and data processing tasks that make up a marine scientist's job.

  3. Reaching lost-to-care populations.

    PubMed

    Jordan, Wilbert C

    2007-12-15

    Identification of patients who are at high risk for human immunodeficiency virus (HIV) infection can lead to reduced frequencies of high-risk behaviors, provision of timely care for infected individuals, and decreased transmission of HIV. The HIV-associated outreach programs at the OASIS Clinic of the King-Harbor/Drew University complex (Los Angeles, CA) has 3 components: a traditional partner-notification (i.e., contact-tracing) component, a focused-intervention component through which clients are given incentives to bring in persons they feel are at high risk for HIV infection, and an outreach component targeting hard-to-reach populations. These interventions are highly effective in identifying individuals early during the course of their disease, when initiation of antiretroviral therapy is most effective. The partner-services program at the OASIS Clinic has been particularly useful in identifying partners of HIV-positive women, whereas the focused-intervention program is most useful for identifying gay men who are unaware of their positive HIV serostatus. Successful targeted outreach programs can identify many individuals who would not otherwise be aware of their HIV infection, but the programs also require more clinicians to manage these patients.

  4. Using New Media to Reach Broad Audiences

    NASA Astrophysics Data System (ADS)

    Gay, P. L.

    2008-06-01

    The International Year of Astronomy New Media Working Group (IYA NMWG) has a singular mission: To flood the Internet with ways to learn about astronomy, interact with astronomers and astronomy content, and socially network with astronomy. Within each of these areas, we seek to build lasting programs and partnerships that will continue beyond 2009. Our weapon of choice is New Media. It is often easiest to define New Media by what it is not. Television, radio, print and their online redistribution of content are not New Media. Many forms of New Media start as user provided content and content infrastructures that answer that individual's creative whim in a way that is adopted by a broader audience. Classic examples include Blogs and Podcasts. This media is typically distributed through content specific websites and RSS feeds, which allow syndication. RSS aggregators (iTunes has audio and video aggregation abilities) allow subscribers to have content delivered to their computers automatically when they connect to the Internet. RSS technology is also being used in such creative ways as allowing automatically updating Google-maps that show the location of someone with an intelligent GPS system, and in sharing 100 word microblogs from anyone (Twitters) through a single feed. In this poster, we outline how the IYA NMWG plans to use New Media to reach target primary audiences of astronomy enthusiasts, image lovers, and amateur astronomers, as well as secondary audiences, including: science fiction fans, online gamers, and skeptics.

  5. Special tool kit aids heavily garmented workers

    NASA Technical Reports Server (NTRS)

    Holmes, A. E.

    1966-01-01

    Triangular aluminum tool kit, filled with polyurethane is constructed to receive various tools and hold them in a snug but quick-release fit as an aid to heavily gloved workers. The kit is designed to allow mounting within easily accessable reach and to provide protection of the tools during storage.

  6. Advances on GRB as cosmological tools

    NASA Astrophysics Data System (ADS)

    Ghirlanda, G.

    2009-05-01

    Several interesting correlations among Gamma Ray Bursts (GRB) prompt and afterglow properties have been found in the recent years. Some of these correlations have been proposed also to standardize GRB energetics to use them as standard candles in constraining the expansion history of the universe up to z>6. However, given the still unexplained nature of most of these correlations, only the less scattered correlations can be used for constraining the cosmological parameters. The updated Epeak-Eγ correlation is presented. Caveats of alternative methods of standardizing GRB energetics are discussed.

  7. New Instrumental Tools for Advanced Astrochemical Applications

    NASA Astrophysics Data System (ADS)

    Steber, Amanda; Zinn, Sabrina; Schnell, Melanie; Rijs, Anouk

    2015-06-01

    Astrochemistry has been a growing field over the past several years. As the data from the Atacama Large Millimeter Array (ALMA) becomes publicly available, new and fast techniques for the analysis of the data will need to be developed, as well as fast, sensitive laboratory techniques. This lab is in the process of building up instrumentation that will be dedicated to the measurement of astrochemically relevant species, both in the microwave and the millimeter wave regimes. Discharge experiments, laser ablation experiments, as well as time of flight measurements will be possible with this instrumentation. Coupled with instrumentation capabilities will be new software aimed at a speeding up the analysis. The laboratory data will be used to search for new molecular signatures in the interstellar medium (ISM), and help to elucidate molecular reaction pathways occurring in the ISM.

  8. Advanced Mathematical Tools in Metrology III

    NASA Astrophysics Data System (ADS)

    Ciarlini, P.

    The Table of Contents for the book is as follows: * Foreword * Invited Papers * The ISO Guide to the Expression of Uncertainty in Measurement: A Bridge between Statistics and Metrology * Bootstrap Algorithms and Applications * The TTRSs: 13 Oriented Constraints for Dimensioning, Tolerancing & Inspection * Graded Reference Data Sets and Performance Profiles for Testing Software Used in Metrology * Uncertainty in Chemical Measurement * Mathematical Methods for Data Analysis in Medical Applications * High-Dimensional Empirical Linear Prediction * Wavelet Methods in Signal Processing * Software Problems in Calibration Services: A Case Study * Robust Alternatives to Least Squares * Gaining Information from Biomagnetic Measurements * Full Papers * Increase of Information in the Course of Measurement * A Framework for Model Validation and Software Testing in Regression * Certification of Algorithms for Determination of Signal Extreme Values during Measurement * A Method for Evaluating Trends in Ozone-Concentration Data and Its Application to Data from the UK Rural Ozone Monitoring Network * Identification of Signal Components by Stochastic Modelling in Measurements of Evoked Magnetic Fields from Peripheral Nerves * High Precision 3D-Calibration of Cylindrical Standards * Magnetic Dipole Estimations for MCG-Data * Transfer Functions of Discrete Spline Filters * An Approximation Method for the Linearization of Tridimensional Metrology Problems * Regularization Algorithms for Image Reconstruction from Projections * Quality of Experimental Data in Hydrodynamic Research * Stochastic Drift Models for the Determination of Calibration Intervals * Short Communications * Projection Method for Lidar Measurement * Photon Flux Measurements by Regularised Solution of Integral Equations * Correct Solutions of Fit Problems in Different Experimental Situations * An Algorithm for the Nonlinear TLS Problem in Polynomial Fitting * Designing Axially Symmetric Electromechanical Systems of Superconducting Magnetic Levitation in Matlab Environment * Data Flow Evaluation in Metrology * A Generalized Data Model for Integrating Clinical Data and Biosignal Records of Patients * Assessment of Three-Dimensional Structures in Clinical Dentistry * Maximum Entropy and Bayesian Approaches to Parameter Estimation in Mass Metrology * Amplitude and Phase Determination of Sinusoidal Vibration in the Nanometer Range using Quadrature Signals * A Class of Symmetric Compactly Supported Wavelets and Associated Dual Bases * Analysis of Surface Topography by Maximum Entropy Power Spectrum Estimation * Influence of Different Kinds of Errors on Imaging Results in Optical Tomography * Application of the Laser Interferometry for Automatic Calibration of Height Setting Micrometer * Author Index

  9. Astronomer's Proposal Tool

    NASA Technical Reports Server (NTRS)

    Krueger, Tony

    2005-01-01

    Astronomer's Proposal Tool (APT) is a computer program that assists astronomers in preparing their Phase 1 and Phase 2 Hubble Space Telescope science programs. APT is a successor to the Remote Proposal Submission System 2 (RPS2) program, which has been rendered obsolete by more recent advances in computer software and hardware. APT exploits advances associated with widespread use of the Internet, multiplatform visual development software tools, and overall increases in the power of desktop computer hardware, all in such a way as to make the preparation and submission of proposals more intuitive and make observatory operations less cumbersome. APT provides documentation and help that are friendly, up to date, and easily accessible to users of varying levels of expertise, while defining an extensible framework that is responsive to changes in both technology and observatory operations. APT consists of two major components: (1) a set of software tools that are intuitive, visual, and responsive and (2) an integrated software environment that unifies all the tools and makes them interoperable. The APT tools include the Visual Target Tuner, Proposal Editor, Exposure Planner, Bright Object Checker, and Visit Planner.

  10. Columbia River Estuary Ecosystem Classification Hydrogeomorphic Reach

    USGS Publications Warehouse

    Cannon, Charles M.; Ramirez, Mary F.; Heatwole, Danelle W.; Burke, Jennifer L.; Simenstad, Charles A.; O'Connor, Jim E.; Marcoe, Keith

    2012-01-01

    Estuarine ecosystems are controlled by a variety of processes that operate at multiple spatial and temporal scales. Understanding the hierarchical nature of these processes will aid in prioritization of restoration efforts. This hierarchical Columbia River Estuary Ecosystem Classification (henceforth "Classification") of the Columbia River estuary is a spatial database of the tidally-influenced reaches of the lower Columbia River, the tidally affected parts of its tributaries, and the landforms that make up their floodplains for the 230 kilometers between the Pacific Ocean and Bonneville Dam. This work is a collaborative effort between University of Washington School of Aquatic and Fishery Sciences (henceforth "UW"), U.S. Geological Survey (henceforth "USGS"), and the Lower Columbia Estuary Partnership (henceforth "EP"). Consideration of geomorphologic processes will improve the understanding of controlling physical factors that drive ecosystem evolution along the tidal Columbia River. The Classification is organized around six hierarchical levels, progressing from the coarsest, regional scale to the finest, localized scale: (1) Ecosystem Province; (2) Ecoregion; (3) Hydrogeomorphic Reach; (4) Ecosystem Complex; (5) Geomorphic Catena; and (6) Primary Cover Class. For Levels 4 and 5, we mapped landforms within the Holocene floodplain primarily by visual interpretation of Light Detection and Ranging (LiDAR) topography supplemented with aerial photographs, Natural Resources Conservation Service (NRCS) soils data, and historical maps. Mapped landforms are classified as to their current geomorphic function, the inferred process regime that formed them, and anthropogenic modification. Channels were classified primarily by a set of depth-based rules and geometric relationships. Classification Level 5 floodplain landforms ("geomorphic catenae") were further classified based on multivariate analysis of land-cover within the mapped landform area and attributed as "sub

  11. The Reach Ratio—A New Indicator for Comparing Quitline Reach Into Smoking Subgroups

    PubMed Central

    2014-01-01

    Introduction: There is growing concern about population disparities in tobacco-related morbidity and mortality. This paper introduces the reach ratio as a complementary measure to reach for monitoring whether quitline interventions are reaching high risk groups of smokers proportionate to their prevalence in the population. Methods: Data on smokers were collected at intake by 7 Canadian provincial quitlines from 2007 to 2009 and grouped to identify 4 high risk subgroups: males, young adults, heavy smokers, and those with low education. Provincial data are from the Canadian Tobacco Use Monitoring Survey. Reach ratios (ReRas), defined as the proportion of quitline callers from a subgroup divided by the proportion of the smoking population in the subgroup, and 95% confidence intervals were calculated for the subgroups. A ReRa of 1.0 indicates proportionate representation. Results: ReRas for male smokers and young adults are consistently less than 1.0 across all provinces, indicating that a lower proportion of these high-risk smokers were receiving evidence-based smoking cessation treatment from quitlines. Those with high levels of tobacco addiction and less than high school education have ReRas greater than 1.0, indicating that a greater proportion of these smokers were receiving cessation treatments. Conclusion: ReRas complement other measures of reach and provide a standardized estimate of the extent to which subgroups of interest are benefiting from available cessation interventions. This information can help quitline operators, funders, and policymakers determine the need for promotional strategies targeted to high risk subgroups, and allocate resources to meet program and policy objectives. PMID:24311698

  12. Perspectives of women with disabilities on reaching those who are hard to reach.

    PubMed

    Smeltzer, Suzanne C; Sharts-Hopko, Nancy C; Ott, Barbara B; Zimmerman, Vanessa; Duffin, Janice

    2007-06-01

    Healthcare needs of women with disabilities are often neglected, even for women who are well connected to the community and to the healthcare system. So-called "hard-to-reach" women, whose degree of disability impedes use of community resources, have even greater difficulty obtaining health care. The purpose of this study was to gain insight into the perceptions of women with mobility and sensory limitations about several healthcare issues that may affect them: barriers to obtaining care, sources of information about health issues, ways to improve access to care, and ways to help hard-to-reach women overcome barriers to health care and health information. Researchers conducted six focus groups, comprising 43 women with limitations of mobility, hearing, or vision. To validate the women's input, researchers conducted two additional focus groups: the first comprised female physicians with special interest in the health care of women with disabilities, and the second included professional administrative staff of agencies that provide services for people with disabilities. In several cases, members of the physician and agency focus groups were themselves women with disabilities. In addition, 16 women with disabilities participated in an online survey; their responses were used to validate the findings of the face-to-face focus groups. Transcribed data were content analyzed and 10 themes identified. Seven of those themes are discussed in this article: communication barriers; lack of knowledge and awareness among healthcare providers; access issues; working the system; system issues; outreach to healthcare providers; and reaching hard-to-reach women. The findings of this study can provide direction to development of more effective outreach to hard-to-reach women with disabilities, resulting in better integration of healthcare services for this population.

  13. Reaching English Language Learners in Every Classroom: Energizers for Teaching and Learning

    ERIC Educational Resources Information Center

    Arechiga, Debbie

    2012-01-01

    Reach all of your English language learners with the effective and engaging approaches in this book. It's filled with practical tools, strategies, and real-world vignettes that will help you teach reading and writing to a diverse student population. The book features "Mental Energizers," aptitudes that will help sustain your commitment as you work…

  14. Corporate Imaging: Teaching Communication Strategies for Reaching Internal and External Publics.

    ERIC Educational Resources Information Center

    Gaulard, Joan Marie

    A corporation's image is a powerful persuasive tool for reaching external publics such as competitors, regulators, and prospective employees. Corporations should avoid disparities between the actual and the desired image, as well as disparities between the external perception and the internal perception of employees. A course was developed at…

  15. Reaching remote areas in Latin America.

    PubMed

    Jaimes, R

    1994-01-01

    Poor communities in remote and inaccessible areas tend to not only be cut off from family planning education and services, but they are also deprived of basic primary health care services. Efforts to bring family planning to such communities and populations should therefore be linked with other services. The author presents three examples of programs to bring effective family planning services to remote communities in Central and South America. Outside of the municipal center in the Tuxtlas region of Mexico, education and health levels are low and people live according to ancient customs. Ten years ago with the help of MEXFAM, the IPPF affiliate in Mexico, two social promoters established themselves in the town of Catemaco to develop a community program of family planning and health care offering education and prevention to improve the quality of people's lives. Through their health brigades taking health services to towns without an established health center, the program has influenced an estimated 100,000 people in 50 villages and towns. The program also has a clinic. In Guatemala, the Family Welfare Association (APROFAM) gave bicycles to 240 volunteer health care workers to facilitate their outreach work in rural areas. APROFAM since 1988 has operated an integrated program to treat intestinal parasites and promote family planning in San Lucas de Toliman, an Indian town close to Lake Atitlan. Providing health care to more than 10,000 people, the volunteer staff has covered the entire department of Solola, reaching each family in the area. Field educators travel on motorcycles through the rural areas of Guatemala coordinating with the health volunteers the distribution of contraceptives at the community level. The Integrated Project's Clinic was founded in 1992 and currently carries out pregnancy and Pap tests, as well as general lab tests. Finally, Puna is an island in the middle of the Gulf of Guayaquil, Ecuador. Women on the island typically have 10

  16. Evaluation of dietary assessment tools used to assess the diet of adults participating in the Communities Advancing the Studies of Tribal Nations Across the Lifespan (CoASTAL) cohort

    PubMed Central

    Fialkowski, Marie K.; McCrory, Megan A.; Roberts, Sparkle M.; Tracy, J. Kathleen; Grattan, Lynn M.

    2011-01-01

    Background Accurate assessment of dietary intake is essential for researchers and public health practitioners to make advancements in health. This is especially important in Native Americans who display disease prevalence rates that are dramatically higher than the general U.S. population. Objective The objective of this study was to evaluate three dietary assessment tools: 1) dietary records, 2) a food frequency questionnaire (FFQ), and 3) a shellfish assessment survey (SAS) among Native American adults from the Communities Advancing Studies of Tribal Nations Across the Lifespan (CoASTAL) cohort. Design CoASTAL was comprised of randomly selected individuals from three tribal registries of Pacific Northwest Tribal Nations. This cross-sectional study used data from the baseline of CoASTAL and was restricted to the non-pregnant adults (18+ yr) who completed the SAS (n=500), a FFQ (n=518), dietary records (n=444), weight measures (n=493), and height measures (n=496). Paired t-tests, Pearson correlation coefficients, and percent agreement were used to evaluate the dietary records and the FFQ with and without accounting for plausibility of reported energy intake (rEI). Sensitivity and specificity as well as Spearman correlation coefficients were used to evaluate the SAS and the FFQ compared to dietary records. Results Statistically significant correlations between the FFQ and dietary records for selected nutrients were not the same by gender. Accounting for plausibility of rEI for the dietary records and the FFQ improved the strength of the correlations for percent energy from protein, energy from carbohydrate, and calcium for both men and women. In addition, significant associations between rEI (dietary records and FFQ) and weight were more apparent when using only rEI considered plausible. The SAS was found to similarly assess shellfish consumption in comparison to the FFQ. Conclusion These results support the benefit of multiple measures of diet, including regional

  17. Monkey see, Monkey reach: Action selection of reaching movements in the macaque monkey

    PubMed Central

    Sartori, Luisa; Camperio-Ciani, Andrea; Bulgheroni, Maria; Castiello, Umberto

    2014-01-01

    Highly efficient systems are needed to link perception with action in the context of the highly complex environments in which primates move and interact. Another important component is, nonetheless, needed for action: selection. When one piece of fruit from a branch is being chosen by a monkey, many other pieces are within reach and visible: do the perceptual features of the objects surrounding a target determine interference effects? In humans, reaching to grasp a desired object appears to integrate the motor features of the objects which might become potential targets - a process which seems to be driven by inhibitory attention mechanisms. Here we show that non-human primates use similar mechanisms when carrying out goal-directed actions. The data indicate that the volumetric features of distractors are internally represented, implying that the basic cognitive operations allowing for action selection have deep evolutionary roots. PMID:24503774

  18. GRIPPING TOOL

    DOEpatents

    Sandrock, R.J.

    1961-12-12

    A self-actuated gripping tool is described for transferring fuel elements and the like into reactors and other inaccessible locations. The tool will grasp or release the load only when properly positioned for this purpose. In addition, the load cannot be released except when unsupported by the tool, so that jarring or contact will not bring about accidental release of the load. The gripping members or jaws of the device are cam-actuated by an axially slidable shaft which has two lockable positions. A spring urges the shaft into one position and a solenoid is provided to overcome the spring and move it into the other position. The weight of the tool operates a sleeve to lock the shaft in its existing position. Only when the cable supporting the tool is slack is the device capable of being actuated either to grasp or release its load. (AEC)

  19. Torque multiplier subsea tool

    SciTech Connect

    Leicht, F. M.; Baugh, B. F.; Palany, H. C.

    1985-10-22

    A torque multiplier subsea tool for setting a seal between a casing hanger and a subsea wellhead includes a mandrel having a sun gear with axial elongate teeth. An outer barrel is disposed around the mandrel forming an annulus therebetween. A planetary gear assembly is disposed in the annulus between the barrel and the sun gear to transmit to the barrel a torque which is higher in magnitude than that applied to the mandrel. A connector body disposed around the mandrel, below the planetary gear assembly, includes radially movable dogs for engaging the casing hanger. The barrel engages the sealing assembly and transmits the increased torque thereto to advance the sealing assembly downwards and to set the seal. The mandrel advances downwards with the sealing assembly and releases the dogs from the casing hanger. An emergency release mechanism is provided to advance the mandrel downwards to release the dogs in the event such downward movement is prevented during normal seal setting operation.

  20. Omics Tools

    SciTech Connect

    Schaumberg, Andrew

    2012-12-21

    The Omics Tools package provides several small trivial tools for work in genomics. This single portable package, the “omics.jar” file, is a toolbox that works in any Java-based environment, including PCs, Macs, and supercomputers. The number of tools is expected to grow. One tool (called cmsearch.hadoop or cmsearch.local), calls the external cmsearch program to predict non-coding RNA in a genome. The cmsearch program is part of the third-party Infernal package. Omics Tools does not contain Infernal. Infernal may be installed separately. The cmsearch.hadoop subtool requires Apache Hadoop and runs on a supercomputer, though cmsearch.local does not and runs on a server. Omics Tools does not contain Hadoop. Hadoop mat be installed separartely The other tools (cmgbk, cmgff, fastats, pal, randgrp, randgrpr, randsub) do not interface with third-party tools. Omics Tools is written in Java and Scala programming languages. Invoking the “help” command shows currently available tools, as shown below: schaumbe@gpint06:~/proj/omics$ java -jar omics.jar help Known commands are: cmgbk : compare cmsearch and GenBank Infernal hits cmgff : compare hits among two GFF (version 3) files cmsearch.hadoop : find Infernal hits in a genome, on your supercomputer cmsearch.local : find Infernal hits in a genome, on your workstation fastats : FASTA stats, e.g. # bases, GC content pal : stem-loop motif detection by palindromic sequence search (code stub) randgrp : random subsample without replacement, of groups randgrpr : random subsample with replacement, of groups (fast) randsub : random subsample without replacement, of file lines For more help regarding a particular command, use: java -jar omics.jar command help Usage: java -jar omics.jar command args

  1. Next Generation CTAS Tools

    NASA Technical Reports Server (NTRS)

    Erzberger, Heinz

    2000-01-01

    The FAA's Free Flight Phase 1 Office is in the process of deploying the current generation of CTAS tools, which are the Traffic Management Advisor (TMA) and the passive Final Approach Spacing Tool (pFAST), at selected centers and airports. Research at NASA is now focussed on extending the CTAS software and computer human interfaces to provide more advanced capabilities. The Multi-center TMA (McTMA) is designed to operate at airports where arrival flows originate from two or more centers whose boundaries are in close proximity to the TRACON boundary. McTMA will also include techniques for routing arrival flows away from congested airspace and around airspace reserved for arrivals into other hub airports. NASA is working with FAA and MITRE to build a prototype McTMA for the Philadelphia airport. The active Final Approach Spacing Tool (aFAST) provides speed and heading advisories to help controllers achieve accurate spacing between aircraft on final approach. These advisories will be integrated with those in the existing pFAST to provide a set of comprehensive advisories for controlling arrival traffic from the TRACON boundary to touchdown at complex, high-capacity airports. A research prototype of aFAST, designed for the Dallas-Fort Worth is in an advanced stage of development. The Expedite Departure Path (EDP) and Direct-To tools are designed to help controllers guide departing aircraft out of the TRACON airspace and to climb to cruise altitude along the most efficient routes.

  2. An EVA Suit Fatigue, Strength, and Reach Model

    NASA Technical Reports Server (NTRS)

    Maida, James C.

    1999-01-01

    The number of Extra-Vehicular Activities (EVAs) performed will increase dramatically with the upcoming Space Station assembly missions. It is estimated that up to 900 EVA hours may be required to assemble the Space Station with an additional 200 hours per year for maintenance requirements. Efficient modeling tools will be essential to assist in planning these EVAS. Important components include strength and fatigue parameters, multi-body dynamics and kinematics. This project is focused on building a model of the EVA crew member encompassing all these capabilities. Phase 1, which is currently underway, involves collecting EMU suited and unsuited fatigue, strength and range of motion data, for all major joints of the body. Phase 2 involves processing the data for model input, formulating comparisons between the EMU suits and deriving generalized relationships between suited and unsuited data. Phase 3 will be formulation of a multi-body dynamics model of the EMU capable of predicting mass handling properties and integration of empirical data into the model. Phase 4 will be validation of the model with collected EMU data from the Neutral Buoyancy Laboratory at NASA/JSC. Engineers and designers will use tie EVA suit database to better understand the capabilities of the suited individuals. This knowledge will lead to better design of tools and planned operations. Mission planners can use the modeling system and view the animations and the visualizations of the various parameters, such as overall fatigue, motion, timelines, reach, and strength to streamline the timing, duration, task arrangement, personnel and overall efficiency of the EVA tasks. Suit designers can use quantifiable data at common biomechanical structure points to better analyze and compare suit performance.

  3. Temporal-spatial reach parameters derived from inertial sensors: Comparison to 3D marker-based motion capture.

    PubMed

    Cahill-Rowley, Katelyn; Rose, Jessica

    2017-02-08

    Reaching is a well-practiced functional task crucial to daily living activities, and temporal-spatial measures of reaching reflect function for both adult and pediatric populations with upper-extremity motor impairments. Inertial sensors offer a mobile and inexpensive tool for clinical assessment of movement. This research outlines a method for measuring temporal-spatial reach parameters using inertial sensors, and validates these measures with traditional marker-based motion capture. 140 reaches from 10 adults, and 30 reaches from nine children aged 18-20 months, were recorded and analyzed using both inertial-sensor and motion-capture methods. Inertial sensors contained three-axis accelerometers, gyroscopes, and magnetometers. Gravitational offset of accelerometer data was measured when the sensor was at rest, and removed using sensor orientation measured at rest and throughout the reach. Velocity was calculated by numeric integration of acceleration, using a null-velocity assumption at reach start. Sensor drift was neglected given the 1-2s required for a reach. Temporal-spatial reach parameters were calculated independently for each data acquisition method. Reach path length and distance, peak velocity magnitude and timing, and acceleration at contact demonstrated consistent agreement between sensor- and motion-capture-based methods, for both adult and toddler reaches, as evaluated by intraclass correlation coefficients from 0.61 to 1.00. Taken together with actual difference between method measures, results indicate that these functional reach parameters may be reliably measured with inertial sensors.

  4. ESA's Venus Express to reach final destination

    NASA Astrophysics Data System (ADS)

    2006-04-01

    burn, at 09:45 (CEST), Venus Express will disappear behind the planet and will not be visible from Earth. This is known as its ‘occultation’ period. The spacecraft will re-emerge from behind Venus’s disc some ten minutes later. So, even with the low gain antenna’s signal, it will only be visible during the first half of the burn and the last six minutes. Receiving the spacecraft signal after the occultation period will be the first positive sign of successful orbit insertion. 11 April, h 11:13 (CEST), re-establish communication with Earth. At the end of the burn, Venus Express still has to perform a few automatic operations. These re-orient the solar panels towards the sun and one of the high gain antennas (the smaller High Gain Antenna 2) towards Earth. If everything goes as expected, at 11:13 the spacecraft should be able to establish its first communication link with ESA’s Cebreros ground station near Madrid. Over the next few hours, it will send much-awaited information about its state of health. Information about its actual trajectory will be available from ESOC’s flight dynamics team around 12:30 (CEST). 12 to 13 April 2006, full reactivation starts. During the 24 hours following orbital capture, time will be devoted to reactivating all spacecraft functions, including all internal monitoring capacity. By the morning of the 13th, the larger ‘High Gain Antenna 1, hitherto unused, will be oriented and fed by the transmitter to communicate with Earth. The two high gain antennas, located on different sides of the spacecraft, will be used alternately during the mission, to avoid exposure to the sun of critical equipment on the outside. Reaching final orbit A series of further manoeuvres and many more days will be required to settle Venus Express into its final orbit. The preliminary nine-day orbit is elliptical, ranging from 350 000 kilometres at its furthest point from the planet (apocentre) to less than 400 kilometres at its closest (pericentre). During

  5. Advanced extravehicular mobility unit study

    NASA Technical Reports Server (NTRS)

    Elkins, W.

    1982-01-01

    Components of the advanced extravehicular mobility unit (suit) are described. Design considerations for radiation protection, extravehicular operational pressure, mobility effects, tool/glove/effector, anthropometric definition, lighting, and equipment turnaround are addressed.

  6. Real-Time Fall Risk Assessment Using Functional Reach Test

    PubMed Central

    Williams, Brian; Allen, Brandon; True, Hanna; Cho, Jin; Harris, Austin; Fell, Nancy

    2017-01-01

    Falls are common and dangerous for survivors of stroke at all stages of recovery. The widespread need to assess fall risk in real time for individuals after stroke has generated emerging requests for a reliable, inexpensive, quantifiable, and remote clinical measure/tool. In order to meet these requests, we explore the Functional Reach Test (FRT) for real-time fall risk assessment and implement the FRT function in mStroke, a real-time and automatic mobile health system for poststroke recovery and rehabilitation. mStroke is designed, developed, and delivered as an Application (App) running on a hardware platform consisting of an iPad and one or two wireless body motion sensors based on different mobile health functions. The FRT function in mStroke is extensively tested on healthy human subjects to verify its concept and feasibility. Preliminary performance will be presented to justify the further exploration of the FRT function in mStroke through clinical trials on individuals after stroke, which may guide its ubiquitous exploitation in the near future. PMID:28167961

  7. Anticipatory eye fixations reveal tool knowledge for tool interaction.

    PubMed

    Belardinelli, Anna; Barabas, Marissa; Himmelbach, Marc; Butz, Martin V

    2016-08-01

    Action-oriented eye-tracking studies have shown that eye fixations reveal much about current behavioral intentions. The eyes typically fixate those positions of a tool or an object where the fingers will be placed next, or those positions in a scene, where obstacles need to be avoided to successfully reach or transport a tool or object. Here, we asked to what extent eye fixations can also reveal active cognitive inference processes, which are expected to integrate bottom-up visual information with internal knowledge for planning suitable object interactions task-dependently. In accordance to the available literature, we expected that task-relevant knowledge will include sensorimotor, semantic, and mechanical aspects. To investigate if and in which way this internal knowledge influences eye fixation behavior while planning an object interaction, we presented pictures of familiar and unfamiliar tools and instructed participants to either pantomime 'lifting' or 'using' the respective tool. When confronted with unfamiliar tools, participants fixated the tool's effector part closer and longer in comparison with familiar tools. This difference was particularly prominent during 'using' trials when compared with 'lifting' trials. We suggest that this difference indicates that the brain actively extracts mechanical information about the unknown tool in order to infer its appropriate usage. Moreover, the successive fixations over a trial indicate that a dynamic, task-oriented, active cognitive process unfolds, which integrates available tool knowledge with visually gathered information to plan and determine the currently intended tool interaction.

  8. Reach and its Impact: NASA and US Aerospace Communities

    NASA Technical Reports Server (NTRS)

    Rothgeb, Matthew J.

    2011-01-01

    REACH is a European law that threatens to impact materials used within the US aerospace communities, including NASA. The presentation briefly covers REACH and generally, its perceived impacts to NASA and the aerospace community within the US.

  9. Advances in genetics and genomics: use and limitations in achieving malaria elimination goals.

    PubMed

    Gunawardena, Sharmini; Karunaweera, Nadira D

    2015-05-01

    Success of the global research agenda towards eradication of malaria will depend on the development of new tools, including drugs, vaccines, insecticides and diagnostics. Genetic and genomic information now available for the malaria parasites, their mosquito vectors and human host, can be harnessed to both develop these tools and monitor their effectiveness. Here we review and provide specific examples of current technological advances and how these genetic and genomic tools have increased our knowledge of host, parasite and vector biology in relation to malaria elimination and in turn enhanced the potential to reach that goal. We then discuss limitations of these tools and future prospects for the successful achievement of global malaria elimination goals.

  10. Advances in genetics and genomics: use and limitations in achieving malaria elimination goals

    PubMed Central

    Gunawardena, Sharmini; Karunaweera, Nadira D.

    2015-01-01

    Success of the global research agenda towards eradication of malaria will depend on the development of new tools, including drugs, vaccines, insecticides and diagnostics. Genetic and genomic information now available for the malaria parasites, their mosquito vectors and human host, can be harnessed to both develop these tools and monitor their effectiveness. Here we review and provide specific examples of current technological advances and how these genetic and genomic tools have increased our knowledge of host, parasite and vector biology in relation to malaria elimination and in turn enhanced the potential to reach that goal. We then discuss limitations of these tools and future prospects for the successful achievement of global malaria elimination goals. PMID:25943157

  11. Reaching hard-to-reach individuals: Nonselective versus targeted outbreak response vaccination for measles.

    PubMed

    Minetti, Andrea; Hurtado, Northan; Grais, Rebecca F; Ferrari, Matthew

    2014-01-15

    Current mass vaccination campaigns in measles outbreak response are nonselective with respect to the immune status of individuals. However, the heterogeneity in immunity, due to previous vaccination coverage or infection, may lead to potential bias of such campaigns toward those with previous high access to vaccination and may result in a lower-than-expected effective impact. During the 2010 measles outbreak in Malawi, only 3 of the 8 districts where vaccination occurred achieved a measureable effective campaign impact (i.e., a reduction in measles cases in the targeted age groups greater than that observed in nonvaccinated districts). Simulation models suggest that selective campaigns targeting hard-to-reach individuals are of greater benefit, particularly in highly vaccinated populations, even for low target coverage and with late implementation. However, the choice between targeted and nonselective campaigns should be context specific, achieving a reasonable balance of feasibility, cost, and expected impact. In addition, it is critical to develop operational strategies to identify and target hard-to-reach individuals.

  12. Advanced electron microscopy for advanced materials.

    PubMed

    Van Tendeloo, Gustaaf; Bals, Sara; Van Aert, Sandra; Verbeeck, Jo; Van Dyck, Dirk

    2012-11-08

    The idea of this Review is to introduce newly developed possibilities of advanced electron microscopy to the materials science community. Over the last decade, electron microscopy has evolved into a full analytical tool, able to provide atomic scale information on the position, nature, and even the valency atoms. This information is classically obtained in two dimensions (2D), but can now also be obtained in 3D. We show examples of applications in the field of nanoparticles and interfaces.

  13. Advanced Monitoring systems initiative

    SciTech Connect

    R.J. Venedam; E.O. Hohman; C.F. Lohrstorfer; S.J. Weeks; J.B. Jones; W.J. Haas

    2004-09-30

    The Advanced Monitoring Systems Initiative (AMSI) actively searches for promising technologies and aggressively moves them from the research bench into DOE/NNSA end-user applications. There is a large unfulfilled need for an active element that reaches out to identify and recruit emerging sensor technologies into the test and evaluation function. Sensor research is ubiquitous, with the seeds of many novel concepts originating in the university systems, but at present these novel concepts do not move quickly and efficiently into real test environments. AMSI is a widely recognized, self-sustaining ''business'' accelerating the selection, development, testing, evaluation, and deployment of advanced monitoring systems and components.

  14. Stretch bending - the plane within the sheet where strains reach the forming limit curve

    NASA Astrophysics Data System (ADS)

    Neuhauser, F. M.; Terrazas, O. R.; Manopulo, N.; Hora, P.; Van Tyne, C. J.

    2016-11-01

    Finite element analysis (FEA) was used to model the angular stretch bend test, where a strip of sheet metal is locked at both ends and a tool with a radius stretches and bends the center of the strip until failure. The FEA program used in the study was Abaqus. The FEA model was verified by experimental work using a dual phase steel (DP600) and with a simplified analytical analysis. The FEA model was used to simulate the experimental test for various frictional conditions and various radii of an upward moving tool. The primary objective of the study was to evaluate the concave-side rule, which states that during stretch bending the forming limit occurs when the strains on the concave surface plane of the bent sheet (i.e. bottom plane) reach the forming limit curve (FLC). The verification with experimental data indicates that the FEA model represents the process very well. Only conditions where failure occurred on or near the tooling are included in the results. The FEA simulations showed that the actual forming limit of the sheet occurs when the strains on the bottom plane of the sheet (i.e. concave side of the bend) reach the forming limit curve for high friction and small tool radii. For lower friction and for larger tool radii the actual forming limit occurs when strains on other planes in the sheet (i.e. mid planes or top surface plane) reach the forming limit curve. The implications of these results suggest that care must be taken in assessing forming operations when both stretch and bending occur. Although it is known that the FLC cannot predict the forming limit for small bend radii, the common assumption that the forming limit occurs when the strains for the middle thickness plane of the sheet reach the forming limit curve or that the concave side rule is often made. Understanding the limits of this assumption needs to be carefully and critically evaluated.

  15. ERF1 -- Enhanced River Reach File 1.2

    USGS Publications Warehouse

    Alexander, Richard B.; Brakebill, John W.; Brew, Robert E.; Smith, Richard A.

    1999-01-01

    U.S. Environmental Protection Agency's River Reach File 1 (RF1) to ensure the hydrologic integrity of the digital reach traces and to quantify the mean water time of travel in river reaches and reservoirs [see USEPA (1996) for a description of the original RF1].

  16. Fluid-Injection Tool for Inaccessible Areas

    NASA Technical Reports Server (NTRS)

    Myers, J. E.

    1982-01-01

    New tool injects liquids or gases into narrow crevices. Can be used to apply caulking and waterproofing compounds, adhesives, detergent, undercoats and oil and to aerate hard-to-reach places. Nozzle can reach into opening 1/32 inch wide to depth of more than 4 inches. Although thin, device is rigid and strong.

  17. Apes produce tools for future use.

    PubMed

    Bräuer, Juliane; Call, Josep

    2015-03-01

    There is now growing evidence that some animal species are able to plan for the future. For example great apes save and exchange tools for future use. Here we raise the question whether chimpanzees, orangutans, and bonobos would produce tools for future use. Subjects only had access to a baited apparatus for a limited duration and therefore should use the time preceding this access to create the appropriate tools in order to get the rewards. The apes were tested in three conditions depending on the need for pre-prepared tools. Either eight tools, one tool or no tools were needed to retrieve the reward. The apes prepared tools in advance for future use and they produced them mainly in conditions when they were really needed. The fact that apes were able to solve this new task indicates that their planning skills are flexible. However, for the condition in which eight tools were needed, apes produced less than two tools per trial in advance. However, they used their chance to produce additional tools in the tool use phase-thus often obtaining most of the reward from the apparatus. Increased pressure to prepare more tools in advance did not have an effect on their performance.

  18. Technology Tools to Support Reading in the Digital Age

    ERIC Educational Resources Information Center

    Biancarosa, Gina; Griffiths, Gina G.

    2012-01-01

    Advances in digital technologies are dramatically altering the texts and tools available to teachers and students. These technological advances have created excitement among many for their potential to be used as instructional tools for literacy education. Yet with the promise of these advances come issues that can exacerbate the literacy…

  19. Spiking and LFP activity in PRR during symbolically instructed reaches.

    PubMed

    Hwang, Eun Jung; Andersen, Richard A

    2012-02-01

    The spiking activity in the parietal reach region (PRR) represents the spatial goal of an impending reach when the reach is directed toward or away from a visual object. The local field potentials (LFPs) in this region also represent the reach goal when the reach is directed to a visual object. Thus PRR is a candidate area for reading out a patient's intended reach goals for neural prosthetic applications. For natural behaviors, reach goals are not always based on the location of a visual object, e.g., playing the piano following sheet music or moving following verbal directions. So far it has not been directly tested whether and how PRR represents reach goals in such cognitive, nonlocational conditions, and knowing the encoding properties in various task conditions would help in designing a reach goal decoder for prosthetic applications. To address this issue, we examined the macaque PRR under two reach conditions: reach goal determined by the stimulus location (direct) or shape (symbolic). For the same goal, the spiking activity near reach onset was indistinguishable between the two tasks, and thus a reach goal decoder trained with spiking activity in one task performed perfectly in the other. In contrast, the LFP activity at 20-40 Hz showed small but significantly enhanced reach goal tuning in the symbolic task, but its spatial preference remained the same. Consequently, a decoder trained with LFP activity performed worse in the other task than in the same task. These results suggest that LFP decoders in PRR should take into account the task context (e.g., locational vs. nonlocational) to be accurate, while spike decoders can robustly provide reach goal information regardless of the task context in various prosthetic applications.

  20. Fluid sampling tool

    DOEpatents

    Garcia, Anthony R.; Johnston, Roger G.; Martinez, Ronald K.

    1999-05-25

    A fluid sampling tool for sampling fluid from a container. The tool has a fluid collecting portion which is drilled into the container wall, thereby affixing it to the wall. The tool may have a fluid extracting section which withdraws fluid collected by the fluid collecting section. The fluid collecting section has a fluted shank with an end configured to drill a hole into a container wall. The shank has a threaded portion for tapping the borehole. The shank is threadably engaged to a cylindrical housing having an inner axial passageway sealed at one end by a septum. A flexible member having a cylindrical portion and a bulbous portion is provided. The housing can be slid into an inner axial passageway in the cylindrical portion and sealed to the flexible member. The bulbous portion has an outer lip defining an opening. The housing is clamped into the chuck of a drill, the lip of the bulbous section is pressed against a container wall until the shank touches the wall, and the user operates the drill. Wall shavings (kerf) are confined in a chamber formed in the bulbous section as it folds when the shank advances inside the container. After sufficient advancement of the shank, an o-ring makes a seal with the container wall.

  1. Fluid sampling tool

    DOEpatents

    Garcia, A.R.; Johnston, R.G.; Martinez, R.K.

    1999-05-25

    A fluid sampling tool is described for sampling fluid from a container. The tool has a fluid collecting portion which is drilled into the container wall, thereby affixing it to the wall. The tool may have a fluid extracting section which withdraws fluid collected by the fluid collecting section. The fluid collecting section has a fluted shank with an end configured to drill a hole into a container wall. The shank has a threaded portion for tapping the borehole. The shank is threadably engaged to a cylindrical housing having an inner axial passageway sealed at one end by a septum. A flexible member having a cylindrical portion and a bulbous portion is provided. The housing can be slid into an inner axial passageway in the cylindrical portion and sealed to the flexible member. The bulbous portion has an outer lip defining an opening. The housing is clamped into the chuck of a drill, the lip of the bulbous section is pressed against a container wall until the shank touches the wall, and the user operates the drill. Wall shavings (kerf) are confined in a chamber formed in the bulbous section as it folds when the shank advances inside the container. After sufficient advancement of the shank, an o-ring makes a seal with the container wall. 6 figs.

  2. Is that within reach? fMRI reveals that the human superior parieto-occipital cortex encodes objects reachable by the hand.

    PubMed

    Gallivan, Jason P; Cavina-Pratesi, Cristiana; Culham, Jody C

    2009-04-08

    Macaque neurophysiology and human neuropsychology results suggest that parietal cortex encodes a unique representation of space within reach of the arm. Here, we used slow event-related functional magnetic resonance imaging (fMRI) to investigate whether human brain areas involved in reaching are more activated by objects within reach versus beyond reach. In experiment 1, graspable objects were placed at three possible locations on a platform: two reachable locations and one beyond reach. On some trials, participants reached to touch or grasp objects at the reachable location; on other trials participants passively viewed objects at one of the three locations. A reach-related area in the superior parieto-occipital cortex (SPOC) was more activated for targets within reach than beyond. In experiment 2, we investigated whether this SPOC response occurred when visual and motor confounds were controlled and whether it was modulated when a tool extended the effective range of the arm. On some trials, participants performed grasping and reaching actions to a reachable object location using either the hand alone or a tool; on other trials, participants passively viewed reachable and unreachable object locations. SPOC was significantly more active for passively viewed objects within reach of the hand versus beyond reach, regardless of whether or not a tool was available. Interestingly, these findings suggest that neural responses within brain areas coding actions (such as SPOC for reaching) may reflect automatic processing of motor affordances (such as reachability with the hand).

  3. Management Tools

    NASA Technical Reports Server (NTRS)

    1987-01-01

    Manugistics, Inc. (formerly AVYX, Inc.) has introduced a new programming language for IBM and IBM compatible computers called TREES-pls. It is a resource management tool originating from the space shuttle, that can be used in such applications as scheduling, resource allocation project control, information management, and artificial intelligence. Manugistics, Inc. was looking for a flexible tool that can be applied to many problems with minimal adaptation. Among the non-government markets are aerospace, other manufacturing, transportation, health care, food and beverage and professional services.

  4. Maximal lateral reaching distance on the affected side using the multi-directional reach test in persons with stroke

    PubMed Central

    Hwang, Won-Jeong; Kim, Jung-Hyun; Jeon, Seo-Hyun; Chung, Yijung

    2015-01-01

    [Purpose] This study aimed to examine the relationship between maximal lateral reaching distance on the affected side and weight shifting using the Multi-directional Reach Test in persons with stoke. [Subjects] Fifty-one chronic stroke participants were recruited from two rehabilitation hospitals. This study administered the Berg Balance Scale, Timed Up-and-Go, Trunk Impairment Scale, Modified Barthel Index and measured different maximal reaching distances. [Results] The maximal lateral reaching distance on the affected side was correlated with the BBS (r=0.571), TUG (r=−0.478), TIS (r=0.561), and MBI scores (r=0.499), the lateral reaching distance in all directions on the non-affected side (r=0.785), the maximal backward reaching distance (r=0.723), and the maximal forward reaching distance (r=0.673). The maximal reaching distance on the affected side was also affected by that on the non-affected side, in addition to the maximal backward reaching distance and MBI score. The final step model of stepwise multiple regression was explained 69.5%. [Conclusion] Maximal lateral reaching distance on the affected side as determined by the Multi-directional Reach Test is a good method of assessing functional performance in stroke patients. Data regarding maximal reaching distance on the non-affected side can be used to measure functional impairment on the affected side in clinical settings. PMID:26504275

  5. Development of Waypoint Planning Tool in Response to NASA Field Campaign Challenges

    NASA Technical Reports Server (NTRS)

    He, Matt; Hardin, Danny; Mayer, Paul; Blakeslee, Richard; Goodman, Michael

    2012-01-01

    Airborne real time observations are a major component of NASA 's Earth Science research and satellite ground validation studies. Multiple aircraft are involved in most NASA field campaigns. The coordination of the aircraft with satellite overpasses, other airplanes and the constantly evolving, dynamic weather conditions often determines the success of the campaign. Planning a research aircraft mission within the context of meeting the science objectives is a complex task because it requires real time situational awareness of the weather conditions that affect the aircraft track. A flight planning tools is needed to provide situational awareness information to the mission scientists, and help them plan and modify the flight tracks. Scientists at the University of Alabama ]Huntsville and the NASA Marshall Space Flight Center developed the Waypoint Planning Tool, an interactive software tool that enables scientists to develop their own flight plans (also known as waypoints) with point -and-click mouse capabilities on a digital map filled with real time raster and vector data. The development of this Waypoint Planning Tool demonstrates the significance of mission support in responding to the challenges presented during NASA field campaigns. Analysis during and after each campaign helped identify both issues and new requirements, and initiated the next wave of development. Currently the Waypoint Planning Tool has gone through three rounds of development and analysis processes. The development of this waypoint tool is directly affected by the technology advances on GIS/Mapping technologies. From the standalone Google Earth application and simple KML functionalities, to Google Earth Plugin on web platform, and to the rising open source GIS tools with New Java Script frameworks, the Waypoint Planning Tool has entered its third phase of technology advancement. Adapting new technologies for the Waypoint Planning Tool ensures its success in helping scientist reach their

  6. Reaching consumers: How the tobacco industry uses email marketing.

    PubMed

    Brock, Betsy; Carlson, Samantha C; Moilanen, Molly; Schillo, Barbara A

    2016-12-01

    Tobacco companies are restricted from engaging in many traditional forms of marketing. Direct marketing is one way tobacco companies can reach consumers while complying with regulation and avoiding negative public perception. There is little research on this type of opt-in marketing, which includes mail marketing, email marketing, web marketing, and mobile marketing, and its impact is not well understood. This study examined 6990 tobacco company emails received by individuals living in the state of Minnesota, US between January 2010 and May 2015 to determine email frequency by brand. These emails were gathered as part of ongoing surveillance of tobacco industry direct marketing. A subset of these emails received between October 2014 and May 2015 (n = 1646) were content analyzed to identify the purpose of the email communication along with type of product promoted. Tobacco companies use email to communicate with consumers on a regular basis. This communication was observed to be as frequent as nine times per month. Emails are most commonly used to promote contests (54.1%), content on tobacco company websites (39.1%), and tobacco coupons (15.7%). Email promotion of menthol-flavored tobacco products was common and was associated with promotion of coupons. Emails promoting menthol had a 1.9 times higher prevalence of also promoting coupons (95% CI: 1.52-2.37). Little is known about tobacco company email marketing and this study fills an identified research gap. A deeper understanding of this type of marketing is needed in order to counter tobacco industry messaging and advance tobacco control.

  7. Aviation Security Cooperation: Advancing Global Vigilance, Global Reach, and Global Power in a Dynamic World

    DTIC Science & Technology

    2014-10-01

    2014 Air & Space Power Journal | 96 Views The Air Force Enjoys a Huge “ Bang for the Buck” for Its Modest Investment in Security Cooperation The Air...continue those benefits into the future. The Air Force does not and should not drive those decisions, but it does have a big stake in the outcome...Reconciling USAF Theory and TACAIR Design with the Demands of Irregular Warfare and Special Operations” (master’s thesis, National Defense Intelligence

  8. Power Plant Model Validation Tool

    SciTech Connect

    2016-02-12

    The PPMV is used to validate generator model using disturbance recordings. The PPMV tool contains a collection of power plant models and model validation studies, as well as disturbance recordings from a number of historic grid events. The user can import data from a new disturbance into the database, which converts PMU and SCADA data into GE PSLF format, and then run the tool to validate (or invalidate) the model for a specific power plant against its actual performance. The PNNL PPMV tool enables the automation of the process of power plant model validation using disturbance recordings. The tool uses PMU and SCADA measurements as input information. The tool automatically adjusts all required EPCL scripts and interacts with GE PSLF in the batch mode. The main tool features includes: - The tool interacts with GE PSLF - The tool uses GE PSLF Play-In Function for generator model validation. - Database of projects (model validation studies) - Database of the historic events. - Database of the power plant - The tool has advanced visualization capabilities - The tool automatically generates reports

  9. Robots Explore the Farthest Reaches of Earth and Space

    NASA Technical Reports Server (NTRS)

    2008-01-01

    "We were the first that ever burst/Into that silent sea," the title character recounts in Samuel Taylor Coleridge s opus Rime of the Ancient Mariner. This famous couplet is equally applicable to undersea exploration today as surface voyages then, and has recently been applied to space travel in the title of a chronicle of the early years of human space flight ("Into That Silent Sea: Trailblazers of the Space Era, 1961-1965"), companion to the +n the Shadow of the Moon book and movie. The parallel is certainly fitting, considering both fields explore unknown, harsh, and tantalizingly inhospitable environments. For starters, exploring the Briny Deep and the Final Frontier requires special vehicles, and the most economical and safest means for each employ remotely operated vehicles (ROVs). ROVs have proven the tool of choice for exploring remote locations, allowing scientists to explore the deepest part of the sea and the furthest reaches of the solar system with the least weight penalty, the most flexibility and specialization of design, and without the need to provide for sustaining human life, or the risk of jeopardizing that life. Most NASA probes, including the historic Voyager I and II spacecraft and especially the Mars rovers, Spirit and Opportunity, feature remote operation, but new missions and new planetary environments will demand new capabilities from the robotic explorers of the future. NASA has an acute interest in the development of specialized ROVs, as new lessons learned on Earth can be applied to new environments and increasingly complex missions in the future of space exploration.

  10. An automatic experimental apparatus to study arm reaching in New World monkeys

    PubMed Central

    Lebedev, Mikhail A.; Nicolelis, Miguel A. L.

    2016-01-01

    Background Several species of the New World monkeys have been used as experimental models in biomedical and neurophysiological research. However, a method for controlled arm reaching tasks has not been developed for these species. New Method We have developed a fully automated, pneumatically driven, portable, and reconfigurable experimental apparatus for arm-reaching tasks suitable for these small primates. Results We have utilized the apparatus to train two owl monkeys in a visually-cued arm-reaching task. Analysis of neural recordings demonstrates directional tuning of the M1 neurons. Comparison with Existing Method(s) Our apparatus allows automated control, freeing the experimenter from manual experiments. Conclusion The presented apparatus provides a valuable tool for conducting neurophysiological research on New World monkeys. PMID:26928257

  11. Action plans can interact to hinder or facilitate reach performance.

    PubMed

    Fournier, Lisa R; Wiediger, Matthew D; Taddese, Ezana F

    2015-11-01

    Executing a reach action can be delayed while retaining another action in working memory (WM) if the two action plans partly overlap rather than do not overlap. This delay (partial repetition cost) occurs when reach responses are under cognitive control. In this study, we investigated whether facilitation (a partial repetition benefit) occurs when reach responses are automatic. We also examined whether the hemisphere controlling the limb or selection of the preferred limb (based on a free-reach task) influences reach performance when the actions partly overlap. Left- and right-handers reached to different stimulus locations to the left and right of body midline with their ipsilateral hand while maintaining an action plan in WM that required the same or the different hand. The results showed a partial repetition benefit for spatially compatible reaches to left and right stimulus locations far from the body midline, but not for those near the body midline. Also, no partial repetition cost was found at any of the stimulus-reach locations. This indicates that automatic reach responses that partly overlap with an action plan maintained in WM are not delayed, but instead can be facilitated (partial repetition benefit). The roles of hemisphere and reach-hand preference in action control and the importance of the degree of feature overlap in obtaining a partial repetition benefit (and cost) are discussed.

  12. Fluid blade disablement tool

    DOEpatents

    Jakaboski, Juan-Carlos [Albuquerque, NM; Hughs, Chance G [Albuquerque, NM; Todd, Steven N [Rio Rancho, NM

    2012-01-10

    A fluid blade disablement (FBD) tool that forms both a focused fluid projectile that resembles a blade, which can provide precision penetration of a barrier wall, and a broad fluid projectile that functions substantially like a hammer, which can produce general disruption of structures behind the barrier wall. Embodiments of the FBD tool comprise a container capable of holding fluid, an explosive assembly which is positioned within the container and which comprises an explosive holder and explosive, and a means for detonating. The container has a concavity on the side adjacent to the exposed surface of the explosive. The position of the concavity relative to the explosive and its construction of materials with thicknesses that facilitate inversion and/or rupture of the concavity wall enable the formation of a sharp and coherent blade of fluid advancing ahead of the detonation gases.

  13. Downhole tool

    DOEpatents

    Hall, David R.; Muradov, Andrei; Pixton, David S.; Dahlgren, Scott Steven; Briscoe, Michael A.

    2007-03-20

    A double shouldered downhole tool connection comprises box and pin connections having mating threads intermediate mating primary and secondary shoulders. The connection further comprises a secondary shoulder component retained in the box connection intermediate a floating component and the primary shoulders. The secondary shoulder component and the pin connection cooperate to transfer a portion of makeup load to the box connection. The downhole tool may be selected from the group consisting of drill pipe, drill collars, production pipe, and reamers. The floating component may be selected from the group consisting of electronics modules, generators, gyroscopes, power sources, and stators. The secondary shoulder component may comprises an interface to the box connection selected from the group consisting of radial grooves, axial grooves, tapered grooves, radial protrusions, axial protrusions, tapered protrusions, shoulders, and threads.

  14. Advanced Tools Webinar Series Presents: Regulatory Issues and Case Studies of Advanced Tools

    EPA Science Inventory

    U.S. EPA has released A Guide for Assessing Biodegradation and Source Identification of Organic Ground Water Contaminants using Compound Specific Isotope Analysis (CSIA) [EPA 600/R-08/148 | December 2008 | www.epa.gov/ada]. The Guide provides recommendations for sample collecti...

  15. Reach Scale Sediment Balance of Goodwin Creek Watershed, Mississippi

    NASA Astrophysics Data System (ADS)

    Ran, L.; Garcia, T.; Ye, S.; Harman, C. J.; Hassan, M. A.; Simon, A.

    2010-12-01

    Several reaches of Goodwin Creek, an experimental watershed within the Mississippi river basin, were analyzed for the period 1977-2007 in terms of long-term trends in sediment gain and loss in each reach, the relation of input and output to within-reach sediment fluxes, and the impacts of land use and bank erosion on reach sediment dynamics. Over the period 1977-2007, degradational and aggradational reaches were identified indicating slight vertical adjustment along the mainstream. Lateral adjustment was the main response of the channel to changes in flow and sediment regimes. Event-based sediment load was estimated using suspended concentration data, bedload transport rate, and changes in cross-sectional data. Bank erosion was estimated using cross-sectional data and models. The spatial and temporal patterns of within-reach sediment dynamics correspond closely with river morphology and also reflect basin conditions over the last three decades; thus they are conditioned by coeval trends in climate, hydrology, and land use. The sediment exchange within the mainstream was calculated by the development of reach sediment balances that reveal complex spatial and temporal patterns of sediment dynamics. Sediment load during the rising limb of the hydrograph was slightly higher than those estimated for the falling limb indicating the relative importance of sediment supply on reach sediment dynamic in the basin. Cumulative plots of sediment exchange reveal that major changes in within reach sediment storage are associated with large floods or major inputs from bank erosion.

  16. Advanced Solar Power Systems

    NASA Technical Reports Server (NTRS)

    Atkinson, J. H.; Hobgood, J. M.

    1984-01-01

    The Advanced Solar Power System (ASPS) concentrator uses a technically sophisticated design and extensive tooling to produce very efficient (80 to 90%) and versatile energy supply equipment which is inexpensive to manufacture and requires little maintenance. The advanced optical design has two 10th order, generalized aspheric surfaces in a Cassegrainian configuration which gives outstanding performance and is relatively insensitive to temperature changes and wind loading. Manufacturing tolerances also have been achieved. The key to the ASPS is the direct absorption of concentrated sunlight in the working fluid by radiative transfers in a black body cavity. The basic ASPS design concepts, efficiency, optical system, and tracking and focusing controls are described.

  17. Advanced flight software reconfiguraton

    NASA Technical Reports Server (NTRS)

    Porcher, Bryan

    1991-01-01

    Information is given in viewgraph form on advanced flight software reconfiguration. Reconfiguration is defined as identifying mission and configuration specific requirements, controlling mission and configuration specific data, binding this information to the flight software code to perform specific missions, and the release and distribution of the flight software. The objectives are to develop, demonstrate, and validate advanced software reconfiguration tools and techniques; to demonstrate reconfiguration approaches on Space Station Freedom (SSF) onboard systems displays; and to interactively test onboard systems displays, flight software, and flight data.

  18. Pilot study: can older inactive adults learn how to reach the required intensity of physical activity guideline?

    PubMed Central

    Bouchard, Danielle R; Langlois, Marie-France; Boisvert-Vigneault, Katherine; Farand, Paul; Paulin, Mathieu; Baillargeon, Jean-Patrice

    2013-01-01

    Most individuals do not reach the recommended physical activity level of at least 150 minutes of aerobic exercise (AE) at moderate-to-vigorous intensity per week. For example, only 13% of older Canadian adults reach World Health Organization physical activity guideline (PAG). One of the reasons might be a difficulty identifying the required intensity. Twenty-five inactive older adults received one session about the AE-PAG and how to use a tool or strategy to help them identify AE intensity: heart-rate (HR) monitor (% of maximal HR; N = 9); manual pulse (% of maximal HR; N = 8); or pedometer (walking cadence; N = 8). Participants had 8 weeks to implement their specific tool with the aim of reaching the PAG by walking at home. At pre- and post-intervention, the capacity to identify AE intensity and AE time spent at moderate-to-vigorous intensity were evaluated. Only the two groups using a tool increased total AE time (both P < 0.01), but no group improved the time spent at moderate-to-vigorous intensity. No significant improvement was observed in the ability to correctly identify AE intensity in any of the groups, but a tendency was observed in the pedometer group (P = 0.07). Using walking cadence with a pedometer should be explored as a tool to reach the PAG as it is inexpensive, easy to use, and seemed the best tool to improve both AE time and perception of intensity. PMID:23662053

  19. Pilot study: can older inactive adults learn how to reach the required intensity of physical activity guideline?

    PubMed

    Bouchard, Danielle R; Langlois, Marie-France; Boisvert-Vigneault, Katherine; Farand, Paul; Paulin, Mathieu; Baillargeon, Jean-Patrice

    2013-01-01

    Most individuals do not reach the recommended physical activity level of at least 150 minutes of aerobic exercise (AE) at moderate-to-vigorous intensity per week. For example, only 13% of older Canadian adults reach World Health Organization physical activity guideline (PAG). One of the reasons might be a difficulty identifying the required intensity. Twenty-five inactive older adults received one session about the AE-PAG and how to use a tool or strategy to help them identify AE intensity: heart-rate (HR) monitor (% of maximal HR; N = 9); manual pulse (% of maximal HR; N = 8); or pedometer (walking cadence; N = 8). Participants had 8 weeks to implement their specific tool with the aim of reaching the PAG by walking at home. At pre- and post-intervention, the capacity to identify AE intensity and AE time spent at moderate-to-vigorous intensity were evaluated. Only the two groups using a tool increased total AE time (both P < 0.01), but no group improved the time spent at moderate-to-vigorous intensity. No significant improvement was observed in the ability to correctly identify AE intensity in any of the groups, but a tendency was observed in the pedometer group (P = 0.07). Using walking cadence with a pedometer should be explored as a tool to reach the PAG as it is inexpensive, easy to use, and seemed the best tool to improve both AE time and perception of intensity.

  20. Validating CAR - A comparison study of experimentally-derived and computer-generated reach envelopes. [Crewstation Assessment of Reach

    NASA Technical Reports Server (NTRS)

    Harris, R.; Bennett, J.; Stokes, J.

    1982-01-01

    In the present investigation, Crewstation Assessment of Reach (CAR) results in the form of male hand reach envelopes were generated and compared with an anthropometric survey performed by Kennedy (1978) to determine the extent of the validity of the CAR model with respect to experimentally-derived anthropometric data. The CAR-generated reach envelopes extensively matched the Kennedy envelopes. The match was particularly good in the areas to the front and side from which the reach originated. Attention is given to the crewstation model, the operator sample population, the CAR analysis, aspects of validation methodology, and the modeling of experimental parameters.

  1. CFD Multiphysics Tool

    NASA Technical Reports Server (NTRS)

    Perrell, Eric R.

    2005-01-01

    The recent bold initiatives to expand the human presence in space require innovative approaches to the design of propulsion systems whose underlying technology is not yet mature. The space propulsion community has identified a number of candidate concepts. A short list includes solar sails, high-energy-density chemical propellants, electric and electromagnetic accelerators, solar-thermal and nuclear-thermal expanders. For each of these, the underlying physics are relatively well understood. One could easily cite authoritative texts, addressing both the governing equations, and practical solution methods for, e.g. electromagnetic fields, heat transfer, radiation, thermophysics, structural dynamics, particulate kinematics, nuclear energy, power conversion, and fluid dynamics. One could also easily cite scholarly works in which complete equation sets for any one of these physical processes have been accurately solved relative to complex engineered systems. The Advanced Concepts and Analysis Office (ACAO), Space Transportation Directorate, NASA Marshall Space Flight Center, has recently released the first alpha version of a set of computer utilities for performing the applicable physical analyses relative to candidate deep-space propulsion systems such as those listed above. PARSEC, Preliminary Analysis of Revolutionary in-Space Engineering Concepts, enables rapid iterative calculations using several physics tools developed in-house. A complete cycle of the entire tool set takes about twenty minutes. PARSEC is a level-zero/level-one design tool. For PARSEC s proof-of-concept, and preliminary design decision-making, assumptions that significantly simplify the governing equation sets are necessary. To proceed to level-two, one wishes to retain modeling of the underlying physics as close as practical to known applicable first principles. This report describes results of collaboration between ACAO, and Embry-Riddle Aeronautical University (ERAU), to begin building a set of

  2. Modifications to the Standard Sit-and-Reach Flexibility Protocol.

    ERIC Educational Resources Information Center

    Holt, Laurence E.; Burke, Darren G.; Pelham, Thomas W.

    1999-01-01

    Describes several modifications of the standard sit-and-reach flexibility protocol using a new device called the multitest flexometer (MTF). Using the MTF, researchers could take six flexibility measures beyond the stand-and-reach test. The modified protocol allowed the indirect assessment of the influence of the four major muscle groups that…

  3. Postural responses to unexpected perturbations of balance during reaching

    PubMed Central

    Trivedi, Hari; Leonard, Julia A.; Ting, Lena H.; Stapley, Paul J.

    2014-01-01

    To study the interaction between feedforward and feedback modes of postural control, we investigated postural responses during unexpected perturbations of the support surface that occurred during forward reaching in a standing position. We examined postural responses in lower limb muscles of 9 human subjects. Baseline measures were obtained when subjects executed reaching movements to a target placed in front of them (R condition) and during postural responses to forward and backward support-surface perturbations (no reaching, P condition) during quiet stance. Perturbations were also given at different delays after the onset of reaching movements (RP conditions) as well as with the arm extended in the direction of the target, but not reaching (P/AE condition). Results showed that during perturbations to reaching (RP), the initial automatic postural response, occurring around 100 ms after the onset of perturbations, was relatively unchanged in latency or amplitude compared to control conditions (P and P/AE). However, longer latency postural responses were modulated to aid in the reaching movements during forward perturbations but not during backward perturbations. Our results suggest that the nervous system prioritizes the maintenance of a stable postural base during reaching, and that later components of the postural responses can be modulated to ensure the performance of the voluntary task. PMID:20035321

  4. Reaching Year 12 in Victoria, Australia: Student and School Influences

    ERIC Educational Resources Information Center

    Marks, Gary

    2014-01-01

    This paper examines student and school influences on reaching Year 12, the final year of schooling in Victoria, Australia. It analyses data from the population of students who were in Year 9 in 2008. Male, English-speaking background, government school, and especially Indigenous students were less likely to reach Year 12 than comparison groups.…

  5. Cognitive Processes Associated with Sequential Tool Use in New Caledonian Crows

    PubMed Central

    Wimpenny, Joanna H.; Weir, Alex A. S.; Clayton, Lisa; Rutz, Christian; Kacelnik, Alex

    2009-01-01

    Background Using tools to act on non-food objects—for example, to make other tools—is considered to be a hallmark of human intelligence, and may have been a crucial step in our evolution. One form of this behaviour, ‘sequential tool use’, has been observed in a number of non-human primates and even in one bird, the New Caledonian crow (Corvus moneduloides). While sequential tool use has often been interpreted as evidence for advanced cognitive abilities, such as planning and analogical reasoning, the behaviour itself can be underpinned by a range of different cognitive mechanisms, which have never been explicitly examined. Here, we present experiments that not only demonstrate new tool-using capabilities in New Caledonian crows, but allow examination of the extent to which crows understand the physical interactions involved. Methodology/Principal Findings In two experiments, we tested seven captive New Caledonian crows in six tasks requiring the use of up to three different tools in a sequence to retrieve food. Our study incorporated several novel features: (i) we tested crows on a three-tool problem (subjects were required to use a tool to retrieve a second tool, then use the second tool to retrieve a third one, and finally use the third one to reach for food); (ii) we presented tasks of different complexity in random rather than progressive order; (iii) we included a number of control conditions to test whether tool retrieval was goal-directed; and (iv) we manipulated the subjects' pre-testing experience. Five subjects successfully used tools in a sequence (four from their first trial), and four subjects repeatedly solved the three-tool condition. Sequential tool use did not require, but was enhanced by, pre-training on each element in the sequence (‘chaining’), an explanation that could not be ruled out in earlier studies. By analyzing tool choice, tool swapping and improvement over time, we show that successful subjects did not use a random probing

  6. Risk Management Implementation Tool

    NASA Technical Reports Server (NTRS)

    Wright, Shayla L.

    2004-01-01

    Continuous Risk Management (CM) is a software engineering practice with processes, methods, and tools for managing risk in a project. It provides a controlled environment for practical decision making, in order to assess continually what could go wrong, determine which risk are important to deal with, implement strategies to deal with those risk and assure the measure effectiveness of the implemented strategies. Continuous Risk Management provides many training workshops and courses to teach the staff how to implement risk management to their various experiments and projects. The steps of the CRM process are identification, analysis, planning, tracking, and control. These steps and the various methods and tools that go along with them, identification, and dealing with risk is clear-cut. The office that I worked in was the Risk Management Office (RMO). The RMO at NASA works hard to uphold NASA s mission of exploration and advancement of scientific knowledge and technology by defining and reducing program risk. The RMO is one of the divisions that fall under the Safety and Assurance Directorate (SAAD). I worked under Cynthia Calhoun, Flight Software Systems Engineer. My task was to develop a help screen for the Continuous Risk Management Implementation Tool (RMIT). The Risk Management Implementation Tool will be used by many NASA managers to identify, analyze, track, control, and communicate risks in their programs and projects. The RMIT will provide a means for NASA to continuously assess risks. The goals and purposes for this tool is to provide a simple means to manage risks, be used by program and project managers throughout NASA for managing risk, and to take an aggressive approach to advertise and advocate the use of RMIT at each NASA center.

  7. Variation in reach-scale bankfull discharge of the Jingjiang Reach undergoing upstream and downstream boundary controls

    NASA Astrophysics Data System (ADS)

    Xia, Junqiang; Zhou, Meirong; Lin, Fenfen; Deng, Shanshan; Lu, Jinyou

    2017-04-01

    Remarkable channel degradation has occurred in the Jingjiang Reach of the Middle Yangtze River, since the operation of the Three Gorges Project, which has caused significant geomorphic adjustments, including the variation in bankfull discharge. Bankfull discharge is a key indicator of flood-discharge capacity in the Jingjiang Reach, which can adjust in response to the altered water and sediment conditions and local base-level changes. Therefore, it is important to investigate the variation in reach-scale bankfull discharge, because of longitudinal variability in channel geometry and bankfull discharge in the study reach. In this study, a general method to calculate the section-scale bankfull discharge using the simulated stage-discharge relation is outlined briefly, and an integrated method is then presented for estimating the reach-scale bankfull discharge. The post-flood reach-scale bankfull discharges in the study reach from 2002 to 2015 were calculated, using the proposed method, based on surveyed post-flood profiles at 171 sections and measured hydrological data at three hydrometric sections and eight water gauge sections. The calculated results indicate that: (i) the reach-scale bankfull discharge in the Jingjiang Reach ranged between 32,731 and 38,949 m3/s over this period, with the average bankfull discharge in the Upper Jingjiang Reach being generally greater than the value in the Lower Jingjiang Reach; (ii) the magnitude of the reach-scale bankfull discharge responded well to the cumulative effect of incoming flow and sediment conditions at the inlet boundary, as well as the change of local base level at the outlet boundary; and (iii) the flood-discharge capacity of the reach was controlled by both the upstream and downstream boundary conditions, and the reach-scale bankfull discharge was expressed by an empirical function of the previous five-year average fluvial erosion intensity during flood seasons at Zhicheng, and the difference between the flood

  8. Recent advances in dermoscopy

    PubMed Central

    Russo, Teresa; Piccolo, Vincenzo; Lallas, Aimilios; Argenziano, Giuseppe

    2016-01-01

    The use of dermoscopy has offered a new morphological dimension of skin lesions and has provided an effective diagnostic tool to differentiate melanoma from other benign or malignant skin tumors but also to support the clinical diagnosis in general dermatology. The aim of this article is to provide an overview of the most recent and important advances in the rising world of dermoscopy. PMID:26949523

  9. Using Facebook to Reach People Who Experience Auditory Hallucinations

    PubMed Central

    Brian, Rachel Marie; Ben-Zeev, Dror

    2016-01-01

    Background Auditory hallucinations (eg, hearing voices) are relatively common and underreported false sensory experiences that may produce distress and impairment. A large proportion of those who experience auditory hallucinations go unidentified and untreated. Traditional engagement methods oftentimes fall short in reaching the diverse population of people who experience auditory hallucinations. Objective The objective of this proof-of-concept study was to examine the viability of leveraging Web-based social media as a method of engaging people who experience auditory hallucinations and to evaluate their attitudes toward using social media platforms as a resource for Web-based support and technology-based treatment. Methods We used Facebook advertisements to recruit individuals who experience auditory hallucinations to complete an 18-item Web-based survey focused on issues related to auditory hallucinations and technology use in American adults. We systematically tested multiple elements of the advertisement and survey layout including image selection, survey pagination, question ordering, and advertising targeting strategy. Each element was evaluated sequentially and the most cost-effective strategy was implemented in the subsequent steps, eventually deriving an optimized approach. Three open-ended question responses were analyzed using conventional inductive content analysis. Coded responses were quantified into binary codes, and frequencies were then calculated. Results Recruitment netted N=264 total sample over a 6-week period. Ninety-seven participants fully completed all measures at a total cost of $8.14 per participant across testing phases. Systematic adjustments to advertisement design, survey layout, and targeting strategies improved data quality and cost efficiency. People were willing to provide information on what triggered their auditory hallucinations along with strategies they use to cope, as well as provide suggestions to others who experience

  10. Tool Gear: Infrastructure for Parallel Tools

    SciTech Connect

    May, J; Gyllenhaal, J

    2003-04-17

    Tool Gear is a software infrastructure for developing performance analysis and other tools. Unlike existing integrated toolkits, which focus on providing a suite of capabilities, Tool Gear is designed to help tool developers create new tools quickly. It combines dynamic instrumentation capabilities with an efficient database and a sophisticated and extensible graphical user interface. This paper describes the design of Tool Gear and presents examples of tools that have been built with it.

  11. Analysis of reaching movements of upper arm in robot assisted exercises. Kinematic assessment of robot assisted upper arm reaching single-joint movements.

    PubMed

    Iuppariello, Luigi; D'Addio, Giovanni; Romano, Maria; Bifulco, Paolo; Lanzillo, Bernardo; Pappone, Nicola; Cesarelli, Mario

    2016-01-01

    Robot-mediated therapy (RMT) has been a very dynamic area of research in recent years. Robotics devices are in fact capable to quantify the performances of a rehabilitation task in treatments of several disorders of the arm and the shoulder of various central and peripheral etiology. Different systems for robot-aided neuro-rehabilitation are available for upper limb rehabilitation but the biomechanical parameters proposed until today, to evaluate the quality of the movement, are related to the specific robot used and to the type of exercise performed. Besides, none study indicated a standardized quantitative evaluation of robot assisted upper arm reaching movements, so the RMT is still far to be considered a standardised tool. In this paper a quantitative kinematic assessment of robot assisted upper arm reaching movements, considering also the effect of gravity on the quality of the movements, is proposed. We studied a group of 10 healthy subjects and results indicate that our advised protocol can be useful for characterising normal pattern in reaching movements.

  12. Development of Waypoint Planning Tool in Response to NASA Field Campaign Challenges

    NASA Technical Reports Server (NTRS)

    He, Matt; Hardin, Danny; Conover, Helen; Graves, Sara; Meyer, Paul; Blakeslee, Richard; Goodman, Michael

    2012-01-01

    Airborne real time observations are a major component of NASA's Earth Science research and satellite ground validation studies. For mission scientists, planning a research aircraft mission within the context of meeting the science objectives is a complex task because it requires real time situational awareness of the weather conditions that affect the aircraft track. Multiple aircrafts are often involved in NASA field campaigns. The coordination of the aircrafts with satellite overpasses, other airplanes and the constantly evolving, dynamic weather conditions often determines the success of the campaign. A flight planning tool is needed to provide situational awareness information to the mission scientists, and help them plan and modify the flight tracks. Scientists at the University of Alabama-Huntsville and the NASA Marshall Space Flight Center developed the Waypoint Planning Tool, an interactive software tool that enables scientists to develop their own flight plans (also known as waypoints) with point -and-click mouse capabilities on a digital map filled with real time raster and vector data. The development of this Waypoint Planning Tool demonstrates the significance of mission support in responding to the challenges presented during NASA field campaigns. Analysis during and after each campaign helped identify both issues and new requirements, and initiated the next wave of development. Currently the Waypoint Planning Tool has gone through three rounds of development and analysis processes. The development of this waypoint tool is directly affected by the technology advances on GIS/Mapping technologies. From the standalone Google Earth application and simple KML functionalities, to Google Earth Plugin and Java Web Start/Applet on web platform, and to the rising open source GIS tools with new JavaScript frameworks, the Waypoint Planning Tool has entered its third phase of technology advancement. The newly innovated, cross ]platform, modular designed Java

  13. The Way Point Planning Tool: Real Time Flight Planning for Airborne Science

    NASA Technical Reports Server (NTRS)

    He, Yubin; Blakeslee, Richard; Goodman, Michael; Hall, John

    2012-01-01

    Airborne real time observation are a major component of NASA's Earth Science research and satellite ground validation studies. For mission scientist, planning a research aircraft mission within the context of meeting the science objective is a complex task because it requires real time situational awareness of the weather conditions that affect the aircraft track. Multiple aircraft are often involved in the NASA field campaigns the coordination of the aircraft with satellite overpasses, other airplanes and the constantly evolving dynamic weather conditions often determine the success of the campaign. A flight planning tool is needed to provide situational awareness information to the mission scientist and help them plan and modify the flight tracks successfully. Scientists at the University of Alabama Huntsville and the NASA Marshal Space Flight Center developed the Waypoint Planning Tool (WPT), an interactive software tool that enables scientist to develop their own flight plans (also known as waypoints), with point and click mouse capabilities on a digital map filled with time raster and vector data. The development of this Waypoint Planning Tool demonstrates the significance of mission support in responding to the challenges presented during NASA field campaigns. Analyses during and after each campaign helped identify both issues and new requirements, initiating the next wave of development. Currently the Waypoint Planning Tool has gone through three rounds of development and analysis processes. The development of this waypoint tool is directly affected by the technology advances on GIS/Mapping technologies. From the standalone Google Earth application and simple KML functionalities to the Google Earth Plugin and Java Web Start/Applet on web platform, as well as to the rising open source GIS tools with new JavaScript frameworks, the Waypoint planning Tool has entered its third phase of technology advancement. The newly innovated, cross-platform, modular designed

  14. Development of Way Point Planning Tool in Response to NASA Field Campaign Challenges

    NASA Astrophysics Data System (ADS)

    He, M.; Hardin, D. M.; Conover, H.; Graves, S. J.; Meyer, P.; Blakeslee, R. J.; Goodman, M. L.

    2012-12-01

    Airborne real time observations are a major component of NASA's Earth Science research and satellite ground validation studies. For mission scientists, planning a research aircraft mission within the context of meeting the science objectives is a complex task because it requires real time situational awareness of the weather conditions that affect the aircraft track. Multiple aircrafts are often involved in NASA field campaigns. The coordination of the aircrafts with satellite overpasses, other airplanes and the constantly evolving, dynamic weather conditions often determines the success of the campaign. A flight planning tool is needed to provide situational awareness information to the mission scientists, and help them plan and modify the flight tracks. Scientists at the University of Alabama-Huntsville and the NASA Marshall Space Flight Center developed the Waypoint Planning Tool, an interactive software tool that enables scientists to develop their own flight plans (also known as waypoints) with point-and-click mouse capabilities on a digital map filled with real time raster and vector data. The development of this Waypoint Planning Tool demonstrates the significance of mission support in responding to the challenges presented during NASA field campaigns. Analysis during and after each campaign helped identify both issues and new requirements, and initiated the next wave of development. Currently the Waypoint Planning Tool has gone through three rounds of development and analysis processes. The development of this waypoint tool is directly affected by the technology advances on GIS/Mapping technologies. From the standalone Google Earth application and simple KML functionalities, to Google Earth Plugin and Java Web Start/Applet on web platform, and to the rising open source GIS tools with new JavaScript frameworks, the Waypoint Planning Tool has entered its third phase of technology advancement. The newly innovated, cross-platform, modular designed Java

  15. Identifying ephemeral and perennial stream reaches using apparent thermal inertia for an ungauged basin: The Rio Salado, Central New Mexico

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Night and day temperature images from Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) remote sensing images are used to identify ephemeral and perennial stream reaches for use in the calibration of an integrated hydrologic model of an ungauged basin. The concept is based on a...

  16. Decoding Movement Goals from the Fronto-Parietal Reach Network

    PubMed Central

    Gertz, Hanna; Lingnau, Angelika; Fiehler, Katja

    2017-01-01

    During reach planning, fronto-parietal brain areas need to transform sensory information into a motor code. It is debated whether these areas maintain a sensory representation of the visual cue or a motor representation of the upcoming movement goal. Here, we present results from a delayed pro-/anti-reach task which allowed for dissociating the position of the visual cue from the reach goal. In this task, the visual cue was combined with a context rule (pro vs. anti) to infer the movement goal. Different levels of movement goal specification during the delay were obtained by presenting the context rule either before the delay together with the visual cue (specified movement goal) or after the delay (underspecified movement goal). By applying functional magnetic resonance imaging (fMRI) multivoxel pattern analysis (MVPA), we demonstrate movement goal encoding in the left dorsal premotor cortex (PMd) and bilateral superior parietal lobule (SPL) when the reach goal is specified. This suggests that fronto-parietal reach regions (PRRs) maintain a prospective motor code during reach planning. When the reach goal is underspecified, only area PMd but not SPL represents the visual cue position indicating an incomplete state of sensorimotor integration. Moreover, this result suggests a potential role of PMd in movement goal selection. PMID:28286476

  17. The impact of REACH on classification for human health hazards.

    PubMed

    Oltmanns, J; Bunke, D; Jenseit, W; Heidorn, C

    2014-11-01

    The REACH Regulation represents a major piece of chemical legislation in the EU and requires manufacturers and importers of chemicals to assess the safety of their substances. The classification of substances for their hazards is one of the crucial elements in this process. We analysed the effect of REACH on classification for human health endpoints by comparing information from REACH registration dossiers with legally binding, harmonised classifications. The analysis included 142 chemicals produced at very high tonnages in the EU, the majority of which have already been assessed in the past. Of 20 substances lacking a harmonised classification, 12 chemicals were classified in REACH registration dossiers. More importantly, 37 substances with harmonised classifications for human health endpoints had stricter classifications in registration dossiers and 29 of these were classified for at least one additional endpoint not covered by the harmonised classification. Substance-specific analyses suggest that one third of these additional endpoints emerged from experimental studies performed to fulfil information requirements under REACH, while two thirds resulted from a new assessment of pre-REACH studies. We conclude that REACH leads to an improved hazard characterisation even for substances with a potentially good data basis.

  18. Environmental stressors afflicting tailwater stream reaches across the United States

    USGS Publications Warehouse

    Miranda, Leandro E.; Krogman, R. M.

    2014-01-01

    The tailwater is the reach of a stream immediately below an impoundment that is hydrologically, physicochemically and biologically altered by the presence and operation of a dam. The overall goal of this study was to gain a nationwide awareness of the issues afflicting tailwater reaches in the United States. Specific objectives included the following: (i) estimate the percentage of reservoirs that support tailwater reaches with environmental conditions suitable for fish assemblages throughout the year, (ii) identify and quantify major sources of environmental stress in those tailwaters that do support fish assemblages and (iii) identify environmental features of tailwater reaches that determine prevalence of key fish taxa. Data were collected through an online survey of fishery managers. Relative to objective 1, 42% of the 1306 reservoirs included in this study had tailwater reaches with sufficient flow to support a fish assemblage throughout the year. The surface area of the reservoir and catchment most strongly delineated reservoirs maintaining tailwater reaches with or without sufficient flow to support a fish assemblage throughout the year. Relative to objective 2, major sources of environmental stress generally reflected flow variables, followed by water quality variables. Relative to objective 3, zoogeography was the primary factor discriminating fish taxa in tailwaters, followed by a wide range of flow and water quality variables. Results for objectives 1–3 varied greatly among nine geographic regions distributed throughout the continental United States. Our results provide a large-scale view of the effects of reservoirs on tailwater reaches and may help guide research and management needs.

  19. Modeling and MBL: Software Tools for Science.

    ERIC Educational Resources Information Center

    Tinker, Robert F.

    Recent technological advances and new software packages put unprecedented power for experimenting and theory-building in the hands of students at all levels. Microcomputer-based laboratory (MBL) and model-solving tools illustrate the educational potential of the technology. These tools include modeling software and three MBL packages (which are…

  20. Advanced transmission studies

    NASA Technical Reports Server (NTRS)

    Coy, John J.; Bill, Robert C.

    1988-01-01

    The NASA Lewis Research Center and the U.S. Army Aviation Systems Command share an interest in advancing the technology for helicopter propulsion systems. In particular, this paper presents highlights from that portion of the program in drive train technology and the related mechanical components. The major goals of the program are to increase the life, reliability, and maintainability; reduce the weight, noise, and vibration; and maintain the relatively high mechanical efficiency of the gear train. The current activity emphasizes noise reduction technology and analytical code development followed by experimental verification. Selected significant advances in technology for transmissions are reviewed, including advanced configurations and new analytical tools. Finally, the plan for future transmission research is presented.

  1. Indispensable tool

    SciTech Connect

    Robinson, Arthur

    2001-08-10

    Synchrotron radiation has become an indispensable research tool for a growing number of scientists in a seemingly ever expanding number of disciplines. We can thank the European Synchrotron Research Facility (ESRF) in Grenoble for taking an innovative step toward achieving the educational goal of explaining the nature and benefits of synchrotron radiation to audiences ranging from the general public (including students) to government officials to scientists who may be unfamiliar with x-ray techniques and synchrotron radiation. ESRF is the driving force behind a new CD-ROM playable on both PCs and Macs titled Synchrotron light to explore matter. Published by Springer-Verlag, the CD contains both English and French versions of a comprehensive overview of the subject.

  2. Hydraulic tool

    SciTech Connect

    Gregory, J.T.

    1988-04-05

    A hydraulic force-delivering tool including a cylinder, a piston slidable in the cylinder and a hydraulic pump to deliver fluid under pressure to the cylinder the hydraulic pump is described, comprising: a pump body; means forming a cylindrical chamber in the pump body; at least one inlet port opening into one end of the chamber from outside the body; means forming an outlet port at the other end of the chamber; a check valve in the outlet port enabling outward flow only; a pump rod plunger reciprocable through a given stroke in the chamber; inner and outer concentric cylindrical surfaces in the chamber and on the plunger, respectively; an annular shoulder on the chamber inner cylindrical surface facing toward the other end of the chamber; an annular seal member slidable along the pump rod and conditioned to seal against the shoulder; and spring means biasing the seal member toward the shoulder.

  3. Optical Tools

    NASA Astrophysics Data System (ADS)

    Roncali, E.; Tavitian, B.; Texier, I. E.; Peltié, P.; Perraut, F.; Boutet, J.; Cognet, L.; Lounis, B.; Marguet, D.; Thoumine, O.; Tramier, M.

    Fluorescence is a physical phenomenon described for the first time in 1852 by the British scientist George G. Stokes, famous for his work in mathematics and hydrodynamics. He observed the light emitted by a mineral after excitation (absorption of light by the mineral) by UV light. He then formulated what has become known as Stokes’ law, which says that the wavelength of fluorescence emission is longer than the excitation wavelength used to generate it. Some phenomena departing from this rule were later discovered, but do not in fact invalidate it. The possibility of visible excitation was subsequently developed, with the discovery of many fluorescing aromaticmolecules, called fluorophores. The identification of these compounds and improved control over the physical phenomenon meant that by 1930 research tools had been developed in biology, e.g., labeling certain tissues and bacteria so as to observe them by fluorescence. The optical microscope as it had existed since the nineteenth century thus gave rise to the fluorescence microscope: a reflection system to supply the light required to excite the fluorophores was added to the standard microscope, together with a suitable filtering system. Fluorescence microscopy soon became an important tool for biological analysis both in vitro and ex vivo, and other applications of light emission were also devised (light-emission phenomena of which fluorescence is a special case, described further in Sect. 7.2). It became possible to study phenomena that could not be observed by standard optical microscopy. Among other things, the location of molecules inside cells, monitoring of intracellular processes, and detection of single molecules all become feasible by means of fluorescence microscopy.

  4. Advanced powder processing

    SciTech Connect

    Janney, M.A.

    1997-04-01

    Gelcasting is an advanced powder forming process. It is most commonly used to form ceramic or metal powders into complex, near-net shapes. Turbine rotors, gears, nozzles, and crucibles have been successfully gelcast in silicon nitride, alumina, nickel-based superalloy, and several steels. Gelcasting can also be used to make blanks that can be green machined to near-net shape and then high fired. Green machining has been successfully applied to both ceramic and metal gelcast blanks. Recently, the authors have used gelcasting to make tooling for metal casting applications. Most of the work has centered on H13 tool steel. They have demonstrated an ability to gelcast and sinter H13 to near net shape for metal casting tooling. Also, blanks of H13 have been cast, green machined into complex shape, and fired. Issues associated with forming, binder burnout, and sintering are addressed.

  5. Test Methods: Cast Plastic Tooling Materials.

    DTIC Science & Technology

    1957-04-01

    The physical and working properties of room temperature curing tooling resin systems are affected by the factors listed below: (a) Temperature of...Hardeners stored exposed to moisture. (h) Presence of moisture in plasters against which the tool surfaces will be made. (i) Types of fillers used in...developed for the plastics industry and its suppliers to facilitate the exchange of test data and to promote the development of materials and techniques which will advance the use of plastics in tooling applications.

  6. Advanced Science.

    ERIC Educational Resources Information Center

    Coles, Mike; Nelms, Rick

    1996-01-01

    Describes a study that explores the depth and breadth of scientific facts, principles, and procedures which are required in the Advanced General National Vocational Qualifications (GNVQ) science through comparison with GCE Advanced level. The final report takes account of the updated 1996 version of GNVQ science. (DDR)

  7. New Stream-Reach Hydropower Development (NSD) Fact Sheet

    SciTech Connect

    2014-04-25

    This fact sheet explores the more than 65 gigawatts (GW) of sustainable hydropower potential in U.S. stream-reaches, according to the hydropower resource assessment funded by DOE and executed by Oak Ridge National Laboratory.

  8. Optic ataxia: from Balint's syndrome to the parietal reach region.

    PubMed

    Andersen, Richard A; Andersen, Kristen N; Hwang, Eun Jung; Hauschild, Markus

    2014-03-05

    Optic ataxia is a high-order deficit in reaching to visual goals that occurs with posterior parietal cortex (PPC) lesions. It is a component of Balint's syndrome that also includes attentional and gaze disorders. Aspects of optic ataxia are misreaching in the contralesional visual field, difficulty preshaping the hand for grasping, and an inability to correct reaches online. Recent research in nonhuman primates (NHPs) suggests that many aspects of Balint's syndrome and optic ataxia are a result of damage to specific functional modules for reaching, saccades, grasp, attention, and state estimation. The deficits from large lesions in humans are probably composite effects from damage to combinations of these functional modules. Interactions between these modules, either within posterior parietal cortex or downstream within frontal cortex, may account for more complex behaviors such as hand-eye coordination and reach-to-grasp.

  9. Birth Defects from Zika More Far-Reaching Than Thought

    MedlinePlus

    ... gov/news/fullstory_162538.html Birth Defects From Zika More Far-Reaching Than Thought Studies found greater ... 14, 2016 WEDNESDAY, Dec. 14, 2016 (HealthDay News) -- Zika's ability to damage the infant brain may be ...

  10. Reaching and Teaching: A Study in Audience Targeting.

    ERIC Educational Resources Information Center

    Ritter, Ellen M.; Welch, Diane T.

    1988-01-01

    Describes a project conducted by the Texas Agricultural Extension Service to market the Family Day Home Care Providers Program to an unknown clientele. Discusses the problems involved in identifying and reaching the target audience. (JOW)

  11. Helping the Library Reach Out to the Future

    MedlinePlus

    ... Bar Home Current Issue Past Issues Helping the Library Reach Out to the Future Past Issues / Fall ... On behalf of the Friends of the National Library of Medicine (FNLM), welcome to the Fall 2007 ...

  12. Compensatory Versus Noncompensatory Shoulder Movements Used for Reaching in Stroke.

    PubMed

    Levin, Mindy F; Liebermann, Dario G; Parmet, Yisrael; Berman, Sigal

    2016-08-01

    Background The extent to which the upper-limb flexor synergy constrains or compensates for arm motor impairment during reaching is controversial. This synergy can be quantified with a minimal marker set describing movements of the arm-plane. Objectives To determine whether and how (a) upper-limb flexor synergy in patients with chronic stroke contributes to reaching movements to different arm workspace locations and (b) reaching deficits can be characterized by arm-plane motion. Methods Sixteen post-stroke and 8 healthy control subjects made unrestrained reaching movements to targets located in ipsilateral, central, and contralateral arm workspaces. Arm-plane, arm, and trunk motion, and their temporal and spatial linkages were analyzed. Results Individuals with moderate/severe stroke used greater arm-plane movement and compensatory trunk movement compared to those with mild stroke and control subjects. Arm-plane and trunk movements were more temporally coupled in stroke compared with controls. Reaching accuracy was related to different segment and joint combinations for each target and group: arm-plane movement in controls and mild stroke subjects, and trunk and elbow movements in moderate/severe stroke subjects. Arm-plane movement increased with time since stroke and when combined with trunk rotation, discriminated between different subject groups for reaching the central and contralateral targets. Trunk movement and arm-plane angle during target reaches predicted the subject group. Conclusions The upper-limb flexor synergy was used adaptively for reaching accuracy by patients with mild, but not moderate/severe stroke. The flexor synergy, as parameterized by the amount of arm-plane motion, can be used by clinicians to identify levels of motor recovery in patients with stroke.

  13. DAMCAL; Damage Reach Stage-Damage Calculation: Users Manual

    DTIC Science & Technology

    1979-02-01

    M AD-A273 611 US Army Corps of Engineers Hydrologic Engineering Center GENERALIZED COMPUTER PROGRAM DTIC "k ELECTE DEC 13 1993 DAMCAL A Damage Reach...Stage- Damage Calculation User’s Manual February 1979 93-30134 ApprOved for Public Release. Distribution Unlimited. CPD-35 93 12 100 3 8 DAMCAL Damage ...Reach Stage- Damage Calculation Accesion For User’s Manual TIS ’C&I DTIC TA.3 Juhfificatoc.n By ............. .......................... February 1979

  14. REACH: next step to a sound chemicals management.

    PubMed

    Van der Wielen, Arnold

    2007-12-01

    REACH is the new European Regulation for Registration, Evaluation, Authorisation and Restriction of Chemicals. It entered into force on 1st June 2007 to streamline and improve the former legislative framework on new and on existing chemical substances of the European Union. Companies which manufacture or import more than 1 tonne of a substance per year will be required to register the substance at the new EU Chemicals Agency located in Helsinki. REACH places greater responsibility on industry to manage the risks that chemicals may pose to the health and the environment and to provide safety information that will be passed down the supply chain. In principle, REACH applies to all chemicals as such, as components in preparations and as used in articles. REACH is a radical step forward in the EU chemicals management. The onus will move from the authorities to industry. In addition, REACH will allow the further evaluation of substances where there are grounds for concern, foresees an authorisation system for the use of substances of very high concern and a system of restrictions, where applicable, for substances of concern. The Authorisation system will require companies to switch progressively to safer alternatives where a suitable alternative exists. Current use restrictions will remain under REACH system.

  15. Reach-scale land use drives the stress responses of a resident stream fish.

    PubMed

    Blevins, Zachary W; Wahl, David H; Suski, Cory D

    2014-01-01

    Abstract To date, relatively few studies have tried to determine the practicality of using physiological information to help answer complex ecological questions and assist in conservation actions aimed at improving conditions for fish populations. In this study, the physiological stress responses of fish were evaluated in-stream between agricultural and forested stream reaches to determine whether differences in these responses can be used as tools to evaluate conservation actions. Creek chub Semotilus atromaculatus sampled directly from forested and agricultural stream segments did not show differences in a suite of physiological indicators. When given a thermal challenge in the laboratory, creek chub sampled from cooler forested stream reaches had higher cortisol levels and higher metabolic stress responses to thermal challenge than creek chub collected from warmer and more thermally variable agricultural reaches within the same stream. Despite fish from agricultural and forested stream segments having different primary and secondary stress responses, fish were able to maintain homeostasis of other physiological indicators to thermal challenge. These results demonstrate that local habitat conditions within discrete stream reaches may impact the stress responses of resident fish and provide insight into changes in community structure and the ability of tolerant fish species to persist in agricultural areas.

  16. Tools Automate Spacecraft Testing, Operation

    NASA Technical Reports Server (NTRS)

    2010-01-01

    "NASA began the Small Explorer (SMEX) program to develop spacecraft to advance astrophysics and space physics. As one of the entities supporting software development at Goddard Space Flight Center, the Hammers Company Inc. (tHC Inc.), of Greenbelt, Maryland, developed the Integrated Test and Operations System to support SMEX. Later, the company received additional Small Business Innovation Research (SBIR) funding from Goddard for a tool to facilitate the development of flight software called VirtualSat. NASA uses the tools to support 15 satellites, and the aerospace industry is using them to develop science instruments, spacecraft computer systems, and navigation and control software."

  17. Concept of REACH and impact on evaluation of chemicals.

    PubMed

    Foth, H; Hayes, Aw

    2008-01-01

    Industrial chemicals have been in use for many decades and new products are regularly invented and introduced to the market. Also for decades, many different chemical laws have been introduced to regulate safe handling of chemicals in different use patterns. The patchwork of current regulation in the European Union is to be replaced by the new regulation on industrial chemical control, REACH. REACH stands for registration, evaluation, and authorization of chemicals. REACH entered force on June 1, 2007. REACH aims to overcome limitations in testing requirements of former regulation on industrial chemicals to enhance competitiveness and innovation with regard to manufacture safer substances and to promote the development of alternative testing methods. A main task of REACH is to address data gaps regarding the properties and uses of industrial chemicals. Producers, importers, and downstream users will have to compile and communicate standard information for all chemicals. Information sets to be prepared include safety data sheets (SDS), chemical safety reports (CSR), and chemical safety assessments (CSA). These are designed to guarantee adequate handling in the production chain, in transport and in use and to prevent the substances from being released to and distributed within the environment. Another important aim is to identify the most harmful chemicals and to set incentives to substitute them with safer alternatives. On one hand, REACH will have substantial impact on the basic understanding of the evaluation of chemicals. However, the toxicological sciences can also substantially influence the workability of REACH that supports the transformation of data to the information required to understand and manage acceptable and non acceptable risks in the use of industrial chemicals. The REACH regulation has been laid down in the main document and 17 Annexes of more than 849 pages. Even bigger technical guidance documents will follow and will inform about the rules for

  18. Reduction of stroke assessment time for visually guided reaching task on KINARM exoskeleton robot.

    PubMed

    Mostafavi, S M; Dukelow, S P; Glasgow, J I; Scott, S H; Mousavi, P

    2014-01-01

    Robotic technologies provide objective, highly reliable tools for assessment of brain function following stroke. KINARM is an exoskeleton device that quantifies sensorimotor brain function using a visually guided reaching task among many other behavioral tasks. As further tasks are developed to more broadly assess different aspects of behavior using the robot, techniques and approaches are required to reduce the time it takes to complete each task. The present study investigates how the value of robot-measured parameters changes under alternative schemes that significantly reduce assessment time compared to the current assessment protocol for the visually guided reaching task. Results of the study are validated by addressing an important diagnostic question using an SVM classifier, showing that the alternative schemes provide nearly identical performance in terms of classification sensitivity, specificity and accuracy.

  19. MIMIC’D Abilities - Tools, Tool Changing, and Robotic Control

    DTIC Science & Technology

    2012-08-01

    EOD ) robots are developed that take advantage of multiple manipulators on the same platform, the demand for more intuitive control and enhanced...technology that has been developed for the Advanced EOD Robotic System (AEODRS) program of record. Because the tool changing technology was based on a...2012 NDIA GROUND VEHICLE SYSTEMS ENGINEERING AND TECHNOLOGY SYMPOSIUM ROBOTIC SYSTEMS (RS) MINI-SYMPOSIUM AUGUST 14-16, MICHIGAN MIMIC’D

  20. Rapid plasticity of motor corticospinal system with robotic reach training.

    PubMed

    Kantak, S S; Jones-Lush, L M; Narayanan, P; Judkins, T N; Wittenberg, G F

    2013-09-05

    Goal-directed reaching is important for the activities of daily living. Populations of neurons in the primary motor cortex that project to spinal motor circuits are known to represent the kinematics of reaching movements. We investigated whether repetitive practice of goal-directed reaching movements induces use-dependent plasticity of those kinematic characteristics, in a manner similar to finger movements, as had been shown previously. Transcranial magnetic stimulation (TMS) was used to evoke upper extremity movements while the forearm was resting in a robotic cradle. Plasticity was measured by the change in kinematics of these evoked movements following goal-directed reaching practice. Baseline direction of TMS-evoked arm movements was determined for each subject. Subjects then practiced three blocks of 160 goal-directed reaching movements in a direction opposite to the baseline direction (14 cm reach 180° from baseline direction) against a 75-Nm spring field. Changes in TMS-evoked whole arm movements were assessed after each practice block and after 5 min following the end of practice. Direction and the position of the point of peak velocity of TMS-evoked movements were significantly altered following training and at a 5-min interval following training, while amplitude did not show significant changes. This was accompanied by changes in the motor-evoked potentials (MEPs) of the shoulder and elbow agonist muscles that partly explained the change in direction, mainly by increase in agonist MEP, without significant changes in antagonists. These findings demonstrate that the arm representation accessible by motor cortical stimulation under goes rapid plasticity induced by goal-directed robotic reach training in healthy subjects.

  1. Memory-guided reaching in a patient with visual hemiagnosia.

    PubMed

    Cornelsen, Sonja; Rennig, Johannes; Himmelbach, Marc

    2016-06-01

    The two-visual-systems hypothesis (TVSH) postulates that memory-guided movements rely on intact functions of the ventral stream. Its particular importance for memory-guided actions was initially inferred from behavioral dissociations in the well-known patient DF. Despite of rather accurate reaching and grasping movements to visible targets, she demonstrated grossly impaired memory-guided grasping as much as impaired memory-guided reaching. These dissociations were later complemented by apparently reversed dissociations in patients with dorsal damage and optic ataxia. However, grasping studies in DF and optic ataxia patients differed with respect to the retinotopic position of target objects, questioning the interpretation of the respective findings as a double dissociation. In contrast, the findings for reaching errors in both types of patients came from similar peripheral target presentations. However, new data on brain structural changes and visuomotor deficits in DF also questioned the validity of a double dissociation in reaching. A severe visuospatial short-term memory deficit in DF further questioned the specificity of her memory-guided reaching deficit. Therefore, we compared movement accuracy in visually-guided and memory-guided reaching in a new patient who suffered a confined unilateral damage to the ventral visual system due to stroke. Our results indeed support previous descriptions of memory-guided movements' inaccuracies in DF. Furthermore, our data suggest that recently discovered optic-ataxia like misreaching in DF is most likely caused by her parieto-occipital and not by her ventral stream damage. Finally, multiple visuospatial memory measurements in HWS suggest that inaccuracies in memory-guided reaching tasks in patients with ventral damage cannot be explained by visuospatial short-term memory or perceptual deficits, but by a specific deficit in visuomotor processing.

  2. Advanced turbine systems program

    SciTech Connect

    Wilkes, C.; Mukavetz, D.W.; Knickerbocker, T.K.; Ali, S.A.

    1992-12-31

    In accordance with the goals of the DOE program, improvements in the gas turbine are the primary focus of Allison activity during Phase I. To this end Allison conducted a survey of potentially applicable gas turbine cycles and selected the advanced combined cycle as reference system. Extensive analysis of two versions of the advanced combined cycle was performed against the requirement for a 60% thermal efficiency (LHV) utility-sized, natural gas fired system. This analysis resulted in technology requirements for this system. Additional analysis determined emissions potential for the system, established a coal-fueled derivative system and a commercialization plan. This report deals with the technical requirements for a system that meets the thermal efficiency goal. Allison initially investigated four basic thermodynamic cycles: Humid air turbine, intercalate-recuperated systems, advanced combined cycle, chemically recuperated cycle. Our survey and cycle analysis indicated that au had the potential of reaching 60% thermal efficiency. We also concluded that engine hot section technology would be a critical technology regardless of which cycle was chosen. Based on this result Allison chose to concentrate on the advanced combined cycle. This cycle is well known and understood by the utility turbine user community and is therefore likely to be acceptable to users.

  3. Advanced turbine systems program

    SciTech Connect

    Wilkes, C.; Mukavetz, D.W.; Knickerbocker, T.K.; Ali, S.A.

    1992-01-01

    In accordance with the goals of the DOE program, improvements in the gas turbine are the primary focus of Allison activity during Phase I. To this end Allison conducted a survey of potentially applicable gas turbine cycles and selected the advanced combined cycle as reference system. Extensive analysis of two versions of the advanced combined cycle was performed against the requirement for a 60% thermal efficiency (LHV) utility-sized, natural gas fired system. This analysis resulted in technology requirements for this system. Additional analysis determined emissions potential for the system, established a coal-fueled derivative system and a commercialization plan. This report deals with the technical requirements for a system that meets the thermal efficiency goal. Allison initially investigated four basic thermodynamic cycles: Humid air turbine, intercalate-recuperated systems, advanced combined cycle, chemically recuperated cycle. Our survey and cycle analysis indicated that au had the potential of reaching 60% thermal efficiency. We also concluded that engine hot section technology would be a critical technology regardless of which cycle was chosen. Based on this result Allison chose to concentrate on the advanced combined cycle. This cycle is well known and understood by the utility turbine user community and is therefore likely to be acceptable to users.

  4. Faculty achievement tracking tool.

    PubMed

    Pettus, Sarah; Reifschneider, Ellen; Burruss, Nancy

    2009-03-01

    Faculty development and scholarship is an expectation of nurse educators. Accrediting institutions, such as the Commission on Collegiate Nursing Education, the National League for Nursing Accrediting Commission, and the Higher Learning Commission, all have criteria regarding faculty achievement. A faculty achievement tracking tool (FATT) was developed to facilitate documentation of accreditation criteria attainment. Based on criteria from accrediting organizations, the roles that are addressed include scholarship, service, and practice. Definitions and benchmarks for the faculty as an aggregate are included. Undergoing reviews from different accrediting organizations, the FATT has been used once for accreditation of the undergraduate program and once for accreditation of the graduate program. The FATT is easy to use and has become an excellent adjunct for the preparation for accreditation reports. In addition, the FATT may be used for yearly evaluations, advancement, and merit.

  5. What causes cooling water temperature gradients in a forested stream reach?

    NASA Astrophysics Data System (ADS)

    Garner, G.; Malcolm, I. A.; Sadler, J. P.; Hannah, D. M.

    2014-12-01

    by cooling of stream water but rather by a combination of reduced rates of heating in the woodland reach and advection of cooler (overnight and early morning) water from the upstream moorland catchment. Longitudinal thermal gradients were indistinct at night and on days when net radiation gains were low (under overcast skies), thus when changes in net energy gains or losses did not vary significantly in space and time, and heat advected into the reach was reasonably consistent. The findings of the study and the modelling approach employed are useful tools for assessing optimal planting strategies for mitigating against ecologically damaging stream temperature maxima.

  6. Reach-Scale Channel Geometry of a Mountain River

    NASA Astrophysics Data System (ADS)

    Wohl, E.; Kuzma, J.; Brown, N.

    2002-12-01

    N. St. Vrain Creek drains 250 km2 of the Colorado Front Range. The basin is underlain by granitic rocks, and the upper half was glaciated. We used 25 study reaches to examine controls on reach-scale channel geometry. Variables measured included channel geometry (width, depth, gradient, bedforms), grain size, and mean velocity. Drainage area at each study reach ranged from 2.2-245 km2, and gradient from 0.013-0.147 m/m. The increase in discharge with drainage area is strongly linear. Channel types included cascade, step-pool, plane-bed and pool-riffle. We examined correlations among (1) the reach-scale response variables bankfull width (w), hydraulic radius (R), mean velocity (v), Darcy-Weisbach ff, bedform wavelength (bw) and amplitude (a), grain size, relative roughness (R/D84) and shear stress (ss), and (2) potential control variables that change progressively downstream (drainage area, discharge) or that are reach-specific (bed gradient). Specifically, we tested the hypothesis that response variables correlate most strongly with local gradient because of the segmented nature of mountain channels. Results from linear regression analyses indicate that most response variables(R/D84, D50, D84, ff, ss) correlate best with gradient, although w, w/d ratio, and bw correlate best with discharge. Multiple regression analyses using Mallow's Cp selection criterion produced similar results in that most response variables correlate strongly with gradient, although the specific variables differ from those selected with linear regressions: w, a, v, ff and ss correlate with gradient, whereas R, bw and v correlate with discharge. These results suggest that the hypothesis is partially supported: channel bed gradient is likely to be a good predictor for many reach-scale response variables along mountain rivers, but discharge is also a good predictor for some response variables. Thus, although subject to strong constraints imposed by changes in gradient and grain size supplied by

  7. Impacts on industry of Europe's emerging chemicals policy REACh.

    PubMed

    Angerer, Gerhard; Nordbeck, Ralf; Sartorius, Christian

    2008-03-01

    For Europe, a new regime in chemicals regulation is about to start. After the proposal of the European Commission concerning the Registration, Evaluation and Authorization of Chemicals (REACh) passed its readings in the European Parliament and some differences with the European Council of Ministers were resolved, the regulation will come into force in June 2007. This paper is focused on the question how serious the cost burdens for industry induced by REACh will be, and whether the New European Member States (NMS) which joined the European Union in May 2004 will be able to cope with the regulation. This evaluation has been done by assessing the legislative, administrative and economic framework in New Member States and by analysing real business cases in companies. The empirical showcase business impact studies are at the same time of interest for companies of EU-15 states, other European countries who may implement the regulation, and even for exporters of raw materials and chemicals outside Europe, who will also have to comply with REACh if they market in the European Community. The results give no indications that REACh adoption will bring significant drawbacks to companies in the NMS. The emerging regulation will bring challenges for individual companies, especially for small and medium-sized ones, but for the European chemical industry as a whole, there is no question that it will be able to cope with REACh burdens without losing its global competitiveness.

  8. Influence of the inter-reach-interval on motor learning.

    PubMed

    Francis, Joseph T

    2005-11-01

    Previous studies have demonstrated changes in motor memories with the passage of time on the order of hours. We sought to further this work by determining the influence that time on the order of seconds has on motor learning by changing the duration between successive reaches (inter-reach-interval (IRI)). Human subjects made reaching movements to visual targets while holding onto a robotic manipulandum that presented a viscous curl field. We tested four experimental groups that differed with respect to the IRI (0.5, 5, 10 or 20 s). The 0.5 s IRI group performed significantly worse with respect to a learning index than the other groups over the first set of 192 reaches. Each group demonstrated significant learning during the first set. There was no significant difference with respect to the learning index between the 5, 10 and 20 s IRI groups. During the second and third set of 192 reaches the 0.5 s IRI group's performance became indistinguishable from the other groups indicating that with continued training the initial deficit in performance could be overcome.

  9. The Cognition of Maximal Reach Distance in Parkinson's Disease.

    PubMed

    Otsuki, Satoru; Nagaoka, Masanori

    2016-01-01

    This study aimed to investigate whether the cognition of spatial distance in reaching movements was decreased in patients with Parkinson's disease (PD) and whether this cognition was associated with various symptoms of PD. Estimated and actual maximal reaching distances were measured in three directions in PD patients and healthy elderly volunteers. Differences between estimated and actual measurements were compared within each group. In the PD patients, the associations between "error in cognition" of reaching distance and "clinical findings" were also examined. The results showed that no differences were observed in any values regardless of dominance of hand and severity of symptoms. The differences between the estimated and actual measurements were negatively deviated in the PD patients, indicating that they tended to underestimate reaching distance. "Error in cognition" of reaching distance correlated with the items of posture in the motor section of the Unified Parkinson's Disease Rating Scale. This suggests that, in PD patients, postural deviation and postural instability might affect the cognition of the distance from a target object.

  10. Health campaign channels: tradeoffs among reach, specificity, and impact.

    PubMed

    Schooler, C; Chaffee, S H; Flora, J A; Roser, C

    1998-03-01

    Stanford University's Five-City Multifactor Risk Reduction Project (FCP) was a 14-year trial of community-wide cardiovascular disease (CVD) risk reduction through integrated programs of community organization and mass media health promotion. The project was launched in 1978 in 5 central California cities, including Monterey, Salinas, Modesto, and San Luis Obispo. TV public service announcements (PSAs), TV shows, booklets, printed tip sheets with brief health suggestions on 7 topics, and newspaper coverage were the types of mass media approaches used in the FCP. These strategies are compared with regard to reach, specificity, and impact for a 5-year study period from 1979/80. Reach is measured as the number of messages intervention community residents remembered, specificity was assessed by examining whether the campaign differentially reached people who were already knowledgeable and practicing cardiovascular disease risk reduction, and impact is defined as the amount of knowledge gained during the course of the campaign. Reach was highest for tip sheets, while specificity was highest for booklets followed by TV programs. Newspaper messages had the most impact, followed by booklets and TV PSAs, tip sheets, and TV programs. Communication channels varied according to reach, specificity, and impact, with each criterion being distinct. No channel was optimal for all 3 of the outcome measures.

  11. Saturated muscle activation contributes to compensatory reaching strategies following stroke

    PubMed Central

    McCrea, Patrick H; Eng, Janice J; Hodgson, Antony J

    2012-01-01

    The control and execution of movement could potentially be altered by the presence of stroke-induced weakness if muscles are incapable of generating sufficient power. The purpose of this study was to identify compensatory strategies during a forward (sagittal) reaching task for twenty persons with chronic stroke and ten healthy age-matched controls. We hypothesized that the paretic anterior deltoid would be maximally activated (i.e., saturated) during a reaching task and that task completion would require activation of additional muscles, resulting in compensatory movements out of the sagittal plane. For reaching movements by control subjects, joint motion remained largely in the sagittal plane and hand trajectories were smooth and direct. Movement characteristics of the non-paretic arm of stroke subjects were similar to control subjects except for small increases in the abduction angle and the percentage that anterior deltoid was activated. In contrast, reaching movements of the paretic arm of stroke subjects were characterized by increased activation of all muscles, especially the lateral deltoid, in addition to the anterior deltoid, with resulting shoulder abduction power and segmented and indirect hand motion. For the paretic arm of stroke subjects, muscle and kinetic compensations increased with impairment severity and weaker muscles were used at a higher percentage of their available muscle activity. These results suggest that the inability to generate sufficient force with the typical agonists involved during a forward reaching task may necessitate compensatory muscle recruitment strategies to complete the task. PMID:16014786

  12. Saturated muscle activation contributes to compensatory reaching strategies after stroke.

    PubMed

    McCrea, Patrick H; Eng, Janice J; Hodgson, Antony J

    2005-11-01

    The control and execution of movement could potentially be altered by the presence of stroke-induced weakness if muscles are incapable of generating sufficient power. The purpose of this study was to identify compensatory strategies during a forward (sagittal) reaching task for 20 persons with chronic stroke and 10 healthy age-matched controls. We hypothesized that the paretic anterior deltoid would be maximally activated (i.e., saturated) during a reaching task and that task completion would require activation of additional muscles, resulting in compensatory movements out of the sagittal plane. For reaching movements by control subjects, joint motion remained largely in the sagittal plane and hand trajectories were smooth and direct. Movement characteristics of the nonparetic arm of stroke subjects were similar to control subjects except for small increases in the abduction angle and the percentage that anterior deltoid was activated. In contrast, reaching movements of the paretic arm of stroke subjects were characterized by increased activation of all muscles, especially the lateral deltoid, in addition to the anterior deltoid, with resulting shoulder abduction power and segmented and indirect hand motion. For the paretic arm of stroke subjects, muscle and kinetic compensations increased with impairment severity and weaker muscles were used at a higher percentage of their available muscle activity. These results suggest that the inability to generate sufficient force with the typical agonists involved during a forward reaching task may necessitate compensatory muscle recruitment strategies to complete the task.

  13. Visually targeted reaching in horse-head grasshoppers.

    PubMed

    Niven, Jeremy E; Ott, Swidbert R; Rogers, Stephen M

    2012-09-22

    Visually targeted reaching to a specific object is a demanding neuronal task requiring the translation of the location of the object from a two-dimensionsal set of retinotopic coordinates to a motor pattern that guides a limb to that point in three-dimensional space. This sensorimotor transformation has been intensively studied in mammals, but was not previously thought to occur in animals with smaller nervous systems such as insects. We studied horse-head grasshoppers (Orthoptera: Proscopididae) crossing gaps and found that visual inputs are sufficient for them to target their forelimbs to a foothold on the opposite side of the gap. High-speed video analysis showed that these reaches were targeted accurately and directly to footholds at different locations within the visual field through changes in forelimb trajectory and body position, and did not involve stereotyped searching movements. The proscopids estimated distant locations using peering to generate motion parallax, a monocular distance cue, but appeared to use binocular visual cues to estimate the distance of nearby footholds. Following occlusion of regions of binocular overlap, the proscopids resorted to peering to target reaches even to nearby locations. Monocular cues were sufficient for accurate targeting of the ipsilateral but not the contralateral forelimb. Thus, proscopids are capable not only of the sensorimotor transformations necessary for visually targeted reaching with their forelimbs but also of flexibly using different visual cues to target reaches.

  14. Unconstrained three-dimensional reaching in rhesus monkeys.

    PubMed

    Jindrich, Devin L; Courtine, Gregoire; Liu, James J; McKay, Heather L; Moseanko, Rod; Bernot, Timothy J; Roy, Roland R; Zhong, Hui; Tuszynski, Mark H; Reggie Edgerton, V

    2011-03-01

    To better understand normative behavior for quantitative evaluation of motor recovery after injury, we studied arm movements by non-injured rhesus monkeys during a food-retrieval task. While seated, monkeys reached, grasped, and retrieved food items. We recorded three-dimensional kinematics and muscle activity, and used inverse dynamics to calculate joint moments due to gravity, segmental interactions, and to the muscles and tissues of the arm. Endpoint paths showed curvature in three dimensions, suggesting that maintaining straight paths was not an important constraint. Joint moments were dominated by gravity. Generalized muscle and interaction moments were less than half of the gravitational moments. The relationships between shoulder and elbow resultant moments were linear during both reach and retrieval. Although both reach and retrieval required elbow flexor moments, an elbow extensor (triceps brachii) was active during both phases. Antagonistic muscles of both the elbow and hand were co-activated during reach and retrieval. Joint behavior could be described by lumped-parameter models analogous to torsional springs at the joints. Minor alterations to joint quasi-stiffness properties, aided by interaction moments, result in reciprocal movements that evolve under the influence of gravity. The strategies identified in monkeys to reach, grasp, and retrieve items will allow the quantification of prehension during recovery after a spinal cord injury and the effectiveness of therapeutic interventions.

  15. Advanced Microsensors

    NASA Technical Reports Server (NTRS)

    1991-01-01

    This video looks at a spinoff application of the technology from advanced microsensors -- those that monitor and determine conditions of spacecraft like the Space Shuttle. The application featured is concerned with the monitoring of the health of premature babies.

  16. An investigation of the neural circuits underlying reaching and reach-to-grasp movements: from planning to execution

    PubMed Central

    Begliomini, Chiara; De Sanctis, Teresa; Marangon, Mattia; Tarantino, Vincenza; Sartori, Luisa; Miotto, Diego; Motta, Raffaella; Stramare, Roberto; Castiello, Umberto

    2014-01-01

    Experimental evidence suggests the existence of a sophisticated brain circuit specifically dedicated to reach-to-grasp planning and execution, both in human and non-human primates (Castiello, 2005). Studies accomplished by means of neuroimaging techniques suggest the hypothesis of a dichotomy between a “reach-to-grasp” circuit, involving the anterior intraparietal area, the dorsal and ventral premotor cortices (PMd and PMv – Castiello and Begliomini, 2008; Filimon, 2010) and a “reaching” circuit involving the medial intraparietal area and the superior parieto-occipital cortex (Culham et al., 2006). However, the time course characterizing the involvement of these regions during the planning and execution of these two types of movements has yet to be delineated. A functional magnetic resonance imaging study has been conducted, including reach-to-grasp and reaching only movements, performed toward either a small or a large stimulus, and Finite Impulse Response model (Henson, 2003) was adopted to monitor activation patterns from stimulus onset for a time window of 10 s duration. Data analysis focused on brain regions belonging either to the reaching or to the grasping network, as suggested by Castiello and Begliomini (2008). Results suggest that reaching and grasping movements planning and execution might share a common brain network, providing further confirmation to the idea that the neural underpinnings of reaching and grasping may overlap in both spatial and temporal terms (Verhagen et al., 2013). But, although responsive for both actions, they show a significant predominance for either one of the two actions and such a preference is evident on a temporal scale. PMID:25228872

  17. The effect of fluid flow on coiled tubing reach

    SciTech Connect

    Bhalla, K.; Walton, I.C.

    1996-12-31

    A critical parameter to the success of many coiled tubing (CT) operations in highly deviated or horizontal wells is the depth penetration that can be attained before the CT buckles and locks up. Achieving a desired depth is always critical in CT operations and attaining an additional reach of a few hundred feet can be crucial. This paper addresses the effect of fluid flow in the CT and in the CT/wellbore annulus on the state of force and stress in the CT, and thereby predicts its effect on the reach attainable by the CT. The flow of fluid through the CT and annulus between the CT and borehole modifies the pressures and the effective force which governs the mechanical stability of the CT. The net force per unit length due to fluid flow in the coiled tubing and annulus between the coiled tubing casing/well is calculated in terms of the shear stress and its effect on the onset of buckling and lockup is determined. The model is then implemented in a full tubing forces calculation and the effect of flowing fluids and producing fluids on reach is analyzed. The new model is utilized in the design of commercial jobs. The exact analytic model shows that fluid flow inside the CT has zero impact on reach, that downward flow in the annulus has a favourable impact, and upward flow in the annulus reduces the maximum attainable reach. Using the full tubing forces model, a coiled tubing job can be designed taking into account the flow of a fluid with a specified rheology, density and flow rate. Thus the feasibility of attaining a given reach can be more accurately determined. Results are presented in the form of the surface weight for commercial wells and compared to field jobs.

  18. Magnitude and extent of flooding at selected river reaches in western Washington, January 2009

    USGS Publications Warehouse

    Mastin, M.C.; Gendaszek, A.S.; Barnas, C.R.

    2010-01-01

    A narrow plume of warm, moist tropical air produced prolonged precipitation and melted snow in low-to-mid elevations throughout western Washington in January 2009. As a result, peak-of-record discharges occurred at many long-term streamflow-gaging stations in the region. A disaster was declared by the President for eight counties in Washington State and by May 2009, aid payments by the Federal Emergency Management Agency (FEMA) had exceeded $17 million. In an effort to document the flood and to obtain flood information that could be compared with simulated flood extents that are commonly prepared in conjunction with flood insurance studies by FEMA, eight stream reaches totaling 32.6 miles were selected by FEMA for inundation mapping. The U.S. Geological Survey?s Washington Water Science Center used a survey-grade global positioning system (GPS) the following summer to survey high-water marks (HWMs) left by the January 2009 flood at these reaches. A Google Maps (copyright) application was developed to display all HWM data on an interactive mapping tool on the project?s web site soon after the data were collected. Water-surface profiles and maps that display the area and depth of inundation were produced through a geographic information system (GIS) analysis that combined surveyed HWM elevations with Light Detection and Ranging (LiDAR)-derived digital elevation models of the study reaches and surrounding terrain. In several of the reaches, floods were well confined in their flood plains and were relatively straightforward to map. More common, however, were reaches with more complicated hydraulic geometries where widespread flooding resulted in flows that separated from the main channel. These proved to be more difficult to map, required subjective hydrologic judgment, and relied on supplementary information, such as aerial photographs and descriptions of the flooding from local landowners and government officials to obtain the best estimates of the extent of flooding.

  19. Predicting Brook Trout occurrence in stream reaches throughout their native range in the eastern United States

    USGS Publications Warehouse

    DeWeber, Jefferson Tyrell; Wagner, Tyler

    2015-01-01

    The Brook Trout Salvelinus fontinalis is an important species of conservation concern in the eastern USA. We developed a model to predict Brook Trout population status within individual stream reaches throughout the species’ native range in the eastern USA. We utilized hierarchical logistic regression with Bayesian estimation to predict Brook Trout occurrence probability, and we allowed slopes and intercepts to vary among ecological drainage units (EDUs). Model performance was similar for 7,327 training samples and 1,832 validation samples based on the area under the receiver operating curve (∼0.78) and Cohen's kappa statistic (0.44). Predicted water temperature had a strong negative effect on Brook Trout occurrence probability at the stream reach scale and was also negatively associated with the EDU average probability of Brook Trout occurrence (i.e., EDU-specific intercepts). The effect of soil permeability was positive but decreased as EDU mean soil permeability increased. Brook Trout were less likely to occur in stream reaches surrounded by agricultural or developed land cover, and an interaction suggested that agricultural land cover also resulted in an increased sensitivity to water temperature. Our model provides a further understanding of how Brook Trout are shaped by habitat characteristics in the region and yields maps of stream-reach-scale predictions, which together can be used to support ongoing conservation and management efforts. These decision support tools can be used to identify the extent of potentially suitable habitat, estimate historic habitat losses, and prioritize conservation efforts by selecting suitable stream reaches for a given action. Future work could extend the model to account for additional landscape or habitat characteristics, include biotic interactions, or estimate potential Brook Trout responses to climate and land use changes.

  20. Telerobotic operation of structurally flexible, long-reach manipulators

    SciTech Connect

    Kwon, D.S.; Hwang, D.H.; Babcock, S.M.

    1994-09-01

    As a part of the Department of Energy`s Environmental Restoration and Waste Management Program, long-reach manipulators are being considered for the retrieval of waste from large storage tanks. Long-reach manipulators may have characteristics significantly different from those of typical industrial robots because of the flexibility of long links needed to cover the large workspace. To avoid structural vibrations during operation, control algorithms employing various types of shaping filters were investigated. A new approach that uses embedded simulation was developed and compared with others. In the new approach, generation of joint trajectories considering link flexibility was also investigated.

  1. Predictive validity of the UPDRS postural stability score and the Functional Reach Test, when compared with ecologically valid reaching tasks.

    PubMed

    Jenkins, M E; Johnson, A M; Holmes, J D; Stephenson, F F; Spaulding, S J

    2010-07-01

    Balance problems and falls are a common concern among individuals with Parkinson's disease (PD). Falls frequently occur during daily activities such as reaching into cupboards in the kitchen or bathroom. This study compared the correlation among two standard postural stability tests - the postural stability score on the Unified Parkinson's Disease Rating Scale (UPDRS) and the Functional Reach Test (FRT) - and ecologically valid reaching tasks that correspond to reaching at different cupboard heights among 20 individuals with PD and 20 age-matched controls. Both the FRT and the UPDRS postural stability tests are quick measures that can be performed during the clinical examination. The FRT, but not the postural stability score, demonstrated a significant correlation with the ecologically valid reaching tasks, among individuals with PD. Furthermore the FRT scores did not correlate with the UPDRS postural stability scores, indicating that these are measuring different aspects of balance. This study suggests that the FRT score may better predict the risk of postural instability encountered during daily activities among individuals with PD.

  2. Head, arm and trunk coordination during reaching in children.

    PubMed

    Sveistrup, H; Schneiberg, S; McKinley, P A; McFadyen, B J; Levin, M F

    2008-06-01

    During postural and locomotor tasks, the orientation of the head with respect to space is maintained in order to serve as an egocentric reference value for maintaining balance. In young children during locomotor tasks, task difficulty determines the coordination of movements between head-trunk segments: the more difficult the task, the more the child limits the head on trunk movement ("en bloc") rather than letting the head move freely in space. For reaching tasks, however, there are no data about the development and maturation of coordination between the head and trunk movements and when the pattern of coordination is considered mature. The goal of this study was to characterize the development of head-trunk coordination during reaching from a sitting position in typically developing children. Forty-four typically-developing (TD) children aged from 2.8 to 11.8 years and six healthy adults participated. Children were divided into five groups (G1-G5) according to their age: 2-3, 4-5, 6-7, 8-9 and 10-11 years old. The task involved reaching towards and grasping a piece of food in the younger group or a wooden block in the older children and adults with the dominant hand, adequate to the grip size of each participant, and returning it to the mouth area to simulate self-feeding. The object was placed in line with the midline of the body at three different distances from the trunk according to the participant's arm length (two within and one beyond arm's length). Rotational movements of the head and trunk in three planes; yaw, roll and pitch, were recorded using three-dimensional tracking systems (Optotrak, Northern Digital, Model 3010 or Ariel Performance Analysis System). The variables analysed were relative head and trunk angle, absolute head and trunk angle, the anchoring index (AI) and initial direction of head and trunk rotation (direction index: DI). Patterns of head-trunk coupling were different along different axes of rotation and across groups. For the AI, a

  3. Detection of self-paced reaching movement intention from EEG signals

    PubMed Central

    Lew, Eileen; Chavarriaga, Ricardo; Silvoni, Stefano; Millán, José del R.

    2012-01-01

    Future neuroprosthetic devices, in particular upper limb, will require decoding and executing not only the user's intended movement type, but also when the user intends to execute the movement. This work investigates the potential use of brain signals recorded non-invasively for detecting the time before a self-paced reaching movement is initiated which could contribute to the design of practical upper limb neuroprosthetics. In particular, we show the detection of self-paced reaching movement intention in single trials using the readiness potential, an electroencephalography (EEG) slow cortical potential (SCP) computed in a narrow frequency range (0.1–1 Hz). Our experiments with 12 human volunteers, two of them stroke subjects, yield high detection rates prior to the movement onset and low detection rates during the non-movement intention period. With the proposed approach, movement intention was detected around 500 ms before actual onset, which clearly matches previous literature on readiness potentials. Interestingly, the result obtained with one of the stroke subjects is coherent with those achieved in healthy subjects, with single-trial performance of up to 92% for the paretic arm. These results suggest that, apart from contributing to our understanding of voluntary motor control for designing more advanced neuroprostheses, our work could also have a direct impact on advancing robot-assisted neurorehabilitation. PMID:23055968

  4. The School Advanced Ventilation Engineering Software (SAVES)

    EPA Pesticide Factsheets

    The School Advanced Ventilation Engineering Software (SAVES) package is a tool to help school designers assess the potential financial payback and indoor humidity control benefits of Energy Recovery Ventilation (ERV) systems for school applications.

  5. Green Energy: Advancing Bio-Hydrogen (Presentation)

    SciTech Connect

    Alber, D.

    2007-07-01

    Developing a model of metabolism linked to H2 production in green algae. Develop tools for parameter discovery and optimization at organism level and advance knowledge of hydrogen-producting photosynthetic organisms.

  6. Clean Cities Tools: Tools to Help You Drive Smarter, Use Less Petroleum, and Reduce Emissions (Brochure)

    SciTech Connect

    Not Available

    2011-06-01

    Clean Cities' Alternative Fuels and Advanced Vehicles Data Center (AFDC) features a wide range of Web-based tools to help vehicle fleets and individual consumers reduce their petroleum use. This brochure lists and describes Clean Cities online tools related to vehicles, alternative fueling stations, electric vehicle charging stations, fuel conservation, emissions reduction, fuel economy, and more.

  7. Clean Cities Tools: Tools to Help You Save Money, Use Less Petroleum, and Reduce Emissions (Brochure)

    SciTech Connect

    Not Available

    2012-01-01

    Clean Cities Alternative Fuels and Advanced Vehicles Data Center (AFDC) features a wide range of Web-based tools to help vehicle fleets and individual consumers reduce their petroleum use. This brochure lists and describes Clean Cities online tools related to vehicles, alternative fueling stations, electric vehicle charging stations, fuel conservation, emissions reduction, fuel economy, and more.

  8. Foundational Tools for Petascale Computing

    SciTech Connect

    Miller, Barton

    2014-05-19

    The Paradyn project has a history of developing algorithms, techniques, and software that push the cutting edge of tool technology for high-end computing systems. Under this funding, we are working on a three-year agenda to make substantial new advances in support of new and emerging Petascale systems. The overall goal for this work is to address the steady increase in complexity of these petascale systems. Our work covers two key areas: (1) The analysis, instrumentation and control of binary programs. Work in this area falls under the general framework of the Dyninst API tool kits. (2) Infrastructure for building tools and applications at extreme scale. Work in this area falls under the general framework of the MRNet scalability framework. Note that work done under this funding is closely related to work done under a contemporaneous grant, “High-Performance Energy Applications and Systems”, SC0004061/FG02-10ER25972, UW PRJ36WV.

  9. Teacher Evaluation in Practice: Implementing Chicago's REACH Students

    ERIC Educational Resources Information Center

    Sporte, Susan E.; Stevens, W. David; Healey, Kaleen; Jiang, Jennie; Hart, Holly

    2013-01-01

    This report focuses on the perceptions and experiences of teachers and administrators during the first year of REACH implementation, which was in many ways a particularly demanding year. These experiences can be helpful to Chicago Public Schools (CPS) and to other districts across the country as they work to restructure and transform teacher…

  10. Reaching the Underserved: Complementary Models of Effective Schooling

    ERIC Educational Resources Information Center

    DeStefano, Joseph; Moore, Audrey-Marie Schuh; Balwanz, David; Hartwell, Ash

    2007-01-01

    Many countries that have undergone expansion of access to public education still face significant disparities in school enrollment and attendance rates at sub-national levels, and fail to reach a high proportion of children who are outside of the government system. Completion and student learning have also continued to be system-wide challenges…

  11. Reaching Rural Communities: Increasing Access to Disability Research Information.

    ERIC Educational Resources Information Center

    Research Exchange, 2002

    2002-01-01

    Nonmetropolitan areas have the highest percentage of people with disabilities, including severe disabilities. However, rural people with disabilities may represent a population that is underserved or difficult to reach. Barriers to information dissemination in rural areas include limited transportation and communications infrastructures, greater…

  12. Settlement Reached at Callahan Mine Superfund Site in Brooksville, Maine

    EPA Pesticide Factsheets

    A settlement has been reached that will facilitate the cleanup of the Callahan Mine Superfund Site in Brooksville, ME. The agreement is between the USEPA, US DOJ, the State of Maine, and site property owner Smith Cove Preservation Trust (Smith Cove).

  13. Science Behind Bars: Reaching Inmates from Rikers Island

    NASA Astrophysics Data System (ADS)

    Mocsy, Agnes

    2017-01-01

    I report on the project ``Science Behind Bars: Reaching Inmates on Rikers Island'' partially funded through an APS Public Outreach and Informing the Public grant. This project involves developing leave-behind materials and setting up meetings to speak with Rikers Island inmates about science, evidence-based reasoning, and the dangers of stereotype threat. APS Mini Grant.

  14. Science Behind Bars: Reaching Inmates on Rikers Island

    NASA Astrophysics Data System (ADS)

    Mócsy, Ágnes

    2016-03-01

    I report on the project ``Science Behind Bars: Reaching Inmates on Rikers Island'' partially funded through an APS Public Outreach and Informing the Public Grant. This project involves setting up meetings to speak with female prisoners on Rikers Island about science, evidence based reasoning and the dangers of stereo-type threat.

  15. Reach for the Stars: Visions for Literacy Coaching Programs

    ERIC Educational Resources Information Center

    DeFord, Diane

    2012-01-01

    This brief by the Literacy Coaching Clearinghouse is about reaching for the stars--stories of vision and commitment from educators in small and large schools. Everyone knows of people who are held up as "visionaries" throughout history: Leonardo Da Vinci, Mahatma Gandhi, Jules Verne, Thomas Edison, Susan Anthony, or John Dewey, to name a few. The…

  16. Research Within Reach: Resources for School Improvement. Final Report.

    ERIC Educational Resources Information Center

    Meehan, Merrill L.

    A detailed report is given on the mechanics involved in conducting a successful bi-regional workshop for educators. The theme of the workshop was designed around two Research Within Reach (RWR) documents dealing with oral/written communications and secondary mathematics; however, papers and discussion generated by the workshop are not included in…

  17. Accessible Buildings for People with Walking and Reaching Limitations.

    ERIC Educational Resources Information Center

    Steinfeld, Edward; And Others

    Research was reviewed and conducted regarding the accessibility of buildings for physically disabled persons. Data was produced regarding anthropometrics (eye level and reach limits for ambulant, semiambulant, and wheelchair bound persons); wheelchair maneuvers; speed and distance (maximum travel distances for people with limitations of stamina);…

  18. Overlapping representations for grip type and reach direction.

    PubMed

    Fabbri, Sara; Strnad, Lukas; Caramazza, Alfonso; Lingnau, Angelika

    2014-07-01

    To grasp an object, we need to move the arm toward it and assume the appropriate hand configuration. While previous studies suggested dorsomedial and dorsolateral pathways in the brain specialized respectively for the transport and grip components, more recent studies cast doubt on such a clear-cut distinction. It is unclear, however, to which degree neuronal populations selective for the two components overlap, and if so, to which degree they interact. Here, we used multivoxel pattern analysis (MVPA) of functional magnetic resonance imaging (fMRI) data to investigate the representation of three center-out movements (touch, pincer grip, whole-hand grip) performed in five reach directions. We found selectivity exclusively for reach direction in posterior and rostral superior parietal lobes (SPLp, SPLr), supplementary motor area (SMA), and the superior portion of dorsal premotor cortex (PMDs). Instead, we found selectivity for both grip type and reach direction in the inferior portion of dorsal premotor cortex (PMDi), ventral premotor cortex (PMv), anterior intraparietal sulcus (aIPS), primary motor (M1), somatosensory (S1) cortices and the anterior superior parietal lobe (SPLa). Within these regions, PMv, M1, aIPS and SPLa showed weak interactions between the transport and grip components. Our results suggest that human PMDi and S1 contain both grip- and reach-direction selective neuronal populations that retain their functional independence, whereas this information might be combined at the level of PMv, M1, aIPS, and SPLa.

  19. 14. RAILROAD BRIDGE MISSISSIPPI, MONROE CO., ABERDEEN Reach by foot ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. RAILROAD BRIDGE MISSISSIPPI, MONROE CO., ABERDEEN Reach by foot from E end of Vine St. St. Louis and San Francisco RR bridge. Bridge built 1887, replaced, 1969. Credit: Evans Memorial Library, Aberdeen, Ms. No date. Sarcone Photography, Columbus, Ms. Sep 1978. - Bridges of the Upper Tombigbee River Valley, Columbus, Lowndes County, MS

  20. 12. INTERIOR VIEW WITH JAMES WILLIAMS REACHING FOR THE SAND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. INTERIOR VIEW WITH JAMES WILLIAMS REACHING FOR THE SAND RELEASE LEVER WHICH WILL OPEN THE OVERHEAD STORAGE BIN AND PERMIT A SET AMOUNT OF SAND TO BE DEPOSITED INTO THE FLASK PRIOR TO COMPRESSION BY THE MOLDING MACHINE INSIDE GREY IRON UNIT NO. 1. - Stockham Pipe & Fittings Company, Grey Iron Foundry, 4000 Tenth Avenue North, Birmingham, Jefferson County, AL