Science.gov

Sample records for advanced research methods

  1. Method and ethics in advancing jury research.

    PubMed

    Robertshaw, P

    1998-10-01

    In this article the contemporary problems of the jury and jury research are considered. This is timely, in view of the current Home Office Consultation Paper on the future of, and alternatives to, the jury in serious fraud trials, to which the author has submitted representations on its jury aspects. The research position is dominated by the prohibitions in the Contempt of Court Act 1981. The types of indirect research on jury deliberation which have been achieved within this stricture are outlined. In the USA, direct research of the jury is possible but, for historical reasons, it has been in television documentaries that direct observation of the deliberation process has been achieved. The first issue is discussed and the problems of inauthenticity, 'the observer effect', and of existential invalidity in 'mock' or 'shadow' juries are noted. Finally, the kinds of issues that could be addressed if licensed jury deliberation research was legalized, are proposed. It is also suggested that there are methods available to transcend the problems associated with American direct research. PMID:9808945

  2. Indentation Methods in Advanced Materials Research Introduction

    SciTech Connect

    Pharr, George Mathews; Cheng, Yang-Tse; Hutchings, Ian; Sakai, Mototsugu; Moody, Neville; Sundararajan, G.; Swain, Michael V.

    2009-01-01

    Since its commercialization early in the 20th century, indentation testing has played a key role in the development of new materials and understanding their mechanical behavior. Progr3ess in the field has relied on a close marriage between research in the mechanical behavior of materials and contact mechanics. The seminal work of Hertz laid the foundations for bringing these two together, with his contributions still widely utilized today in examining elastic behavior and the physics of fracture. Later, the pioneering work of Tabor, as published in his classic text 'The Hardness of Metals', exapdned this understanding to address the complexities of plasticity. Enormous progress in the field has been achieved in the last decade, made possible both by advances in instrumentation, for example, load and depth-sensing indentation and scanning electron microscopy (SEM) and transmission electron microscopy (TEM) based in situ testing, as well as improved modeling capabilities that use computationally intensive techniques such as finite element analysis and molecular dynamics simulation. The purpose of this special focus issue is to present recent state of the art developments in the field.

  3. Advancements in Research Synthesis Methods: From a Methodologically Inclusive Perspective

    ERIC Educational Resources Information Center

    Suri, Harsh; Clarke, David

    2009-01-01

    The dominant literature on research synthesis methods has positivist and neo-positivist origins. In recent years, the landscape of research synthesis methods has changed rapidly to become inclusive. This article highlights methodologically inclusive advancements in research synthesis methods. Attention is drawn to insights from interpretive,…

  4. Strategy to Promote Active Learning of an Advanced Research Method

    ERIC Educational Resources Information Center

    McDermott, Hilary J.; Dovey, Terence M.

    2013-01-01

    Research methods courses aim to equip students with the knowledge and skills required for research yet seldom include practical aspects of assessment. This reflective practitioner report describes and evaluates an innovative approach to teaching and assessing advanced qualitative research methods to final-year psychology undergraduate students. An…

  5. Advances in Statistical Methods for Substance Abuse Prevention Research

    PubMed Central

    MacKinnon, David P.; Lockwood, Chondra M.

    2010-01-01

    The paper describes advances in statistical methods for prevention research with a particular focus on substance abuse prevention. Standard analysis methods are extended to the typical research designs and characteristics of the data collected in prevention research. Prevention research often includes longitudinal measurement, clustering of data in units such as schools or clinics, missing data, and categorical as well as continuous outcome variables. Statistical methods to handle these features of prevention data are outlined. Developments in mediation, moderation, and implementation analysis allow for the extraction of more detailed information from a prevention study. Advancements in the interpretation of prevention research results include more widespread calculation of effect size and statistical power, the use of confidence intervals as well as hypothesis testing, detailed causal analysis of research findings, and meta-analysis. The increased availability of statistical software has contributed greatly to the use of new methods in prevention research. It is likely that the Internet will continue to stimulate the development and application of new methods. PMID:12940467

  6. Advances and future directions of research on spectral methods

    NASA Technical Reports Server (NTRS)

    Patera, A. T.

    1986-01-01

    Recent advances in spectral methods are briefly reviewed and characterized with respect to their convergence and computational complexity. Classical finite element and spectral approaches are then compared, and spectral element (or p-type finite element) approximations are introduced. The method is applied to the full Navier-Stokes equations, and examples are given of the application of the technique to several transitional flows. Future directions of research in the field are outlined.

  7. Advances in microfluidics-based experimental methods for neuroscience research.

    PubMed

    Park, Jae Woo; Kim, Hyung Joon; Kang, Myeong Woo; Jeon, Noo Li

    2013-02-21

    The application of microfluidics to neuroscience applications has always appealed to neuroscientists because of the capability to control the cellular microenvironment in both a spatial and temporal manner. Recently, there has been rapid development of biological micro-electro-mechanical systems (BioMEMS) for both fundamental and applied neuroscience research. In this review, we will discuss the applications of BioMEMS to various topics in the field of neuroscience. The purpose of this review is to summarise recent advances in the components and design of the BioMEMS devices, in vitro disease models, electrophysiology and neural stem cell research. We envision that microfluidics will play a key role in future neuroscience research, both fundamental and applied research.

  8. Research Advances

    ERIC Educational Resources Information Center

    King, Angela G.

    2004-01-01

    Research advances, a new feature in Journal of Chemical Engineering that brings information about innovations in current areas of research to high school and college science faculty with an intent to provide educators with timely descriptions of latest progress in research that can be integrated into existing courses to update course content and…

  9. Review: Advances in delta-subsidence research using satellite methods

    NASA Astrophysics Data System (ADS)

    Higgins, Stephanie A.

    2016-05-01

    Most of the world's major river deltas are sinking relative to local sea level. The effects of subsidence can include aquifer salinization, infrastructure damage, increased vulnerability to flooding and storm surges, and permanent inundation of low-lying land. Consequently, determining the relative importance of natural vs. anthropogenic pressures in driving delta subsidence is a topic of ongoing research. This article presents a review of knowledge with respect to delta surface-elevation loss. The field is rapidly advancing due to applications of space-based techniques: InSAR (interferometric synthetic aperture radar), GPS (global positioning system), and satellite ocean altimetry. These techniques have shed new light on a variety of subsidence processes, including tectonics, isostatic adjustment, and the spatial and temporal variability of sediment compaction. They also confirm that subsidence associated with fluid extraction can outpace sea-level rise by up to two orders of magnitude, resulting in effective sea-level rise that is one-hundred times faster than the global average rate. In coming years, space-based and airborne instruments will be critical in providing near-real-time monitoring to facilitate management decisions in sinking deltas. However, ground-based observations continue to be necessary for generating complete measurements of surface-elevation change. Numerical modeling should seek to simulate couplings between subsidence processes for greater predictive power.

  10. Research Advances

    ERIC Educational Resources Information Center

    King, Angela G.

    2004-01-01

    Nanotechnology are employed by researchers at Northwestern University to develop a method of labeling disease markers present in blood with unique DNA tags they have dubbed "bio-bar-codes". The preparation of nanoparticle and magnetic microparticle probes and a nanoparticle-based PSR-less DNA amplification scheme are involved by the DNA-BCA assay.

  11. ADVANCING THE STUDY OF VIOLENCE AGAINST WOMEN USING MIXED METHODS: INTEGRATING QUALITATIVE METHODS INTO A QUANTITATIVE RESEARCH PROGRAM

    PubMed Central

    Testa, Maria; Livingston, Jennifer A.; VanZile-Tamsen, Carol

    2011-01-01

    A mixed methods approach, combining quantitative with qualitative data methods and analysis, offers a promising means of advancing the study of violence. Integrating semi-structured interviews and qualitative analysis into a quantitative program of research on women’s sexual victimization has resulted in valuable scientific insight and generation of novel hypotheses for testing. This mixed methods approach is described and recommendations for integrating qualitative data into quantitative research are provided. PMID:21307032

  12. Advancing the study of violence against women using mixed methods: integrating qualitative methods into a quantitative research program.

    PubMed

    Testa, Maria; Livingston, Jennifer A; VanZile-Tamsen, Carol

    2011-02-01

    A mixed methods approach, combining quantitative with qualitative data methods and analysis, offers a promising means of advancing the study of violence. Integrating semi-structured interviews and qualitative analysis into a quantitative program of research on women's sexual victimization has resulted in valuable scientific insight and generation of novel hypotheses for testing. This mixed methods approach is described and recommendations for integrating qualitative data into quantitative research are provided.

  13. Advancing the science of research in nursing education: contributions of the critical decision method.

    PubMed

    McNelis, Angela M; Ironside, Pamela M; Zvonar, Sarah E; Ebright, Patricia R

    2014-02-01

    Advancing the science of nursing education will require the discipline to conduct research that investigates complex phenomena, such as students' clinical thinking and decision-making skills, using multiple methods. The research methods developed in other disciplines can provide nursing education researchers with new ways to investigate clinical teaching and learning in nursing. The critical decision method (CDM), derived from psychology and human factors engineering, is a technique by which researchers elicit experts' thinking and the cognitive work informing decision making in the context of practice. This article describes how the CDM was adapted to study nursing students' situation awareness, cues for action, and pattern recognition during clinical experiences. The CDM is a promising method for investigators to use to conduct research in nursing education and to inform the design of clinical experiences to promote these critical abilities.

  14. Research Advances

    ERIC Educational Resources Information Center

    King, Angela G.

    2005-01-01

    Researchers in the Department of Bioengineering at Rice University are developing a new approach for fighting cancer, based on nanoshells that can both detect and destroy cancerous cells. The aim is to locate the cells, and be able to make a rational choice about whether they need to be destroyed and if possible they should immediately be sent for…

  15. Setting health research priorities using the CHNRI method: IV. Key conceptual advances

    PubMed Central

    Rudan, Igor

    2016-01-01

    Introduction Child Health and Nutrition Research Initiative (CHNRI) started as an initiative of the Global Forum for Health Research in Geneva, Switzerland. Its aim was to develop a method that could assist priority setting in health research investments. The first version of the CHNRI method was published in 2007–2008. The aim of this paper was to summarize the history of the development of the CHNRI method and its key conceptual advances. Methods The guiding principle of the CHNRI method is to expose the potential of many competing health research ideas to reduce disease burden and inequities that exist in the population in a feasible and cost–effective way. Results The CHNRI method introduced three key conceptual advances that led to its increased popularity in comparison to other priority–setting methods and processes. First, it proposed a systematic approach to listing a large number of possible research ideas, using the “4D” framework (description, delivery, development and discovery research) and a well–defined “depth” of proposed research ideas (research instruments, avenues, options and questions). Second, it proposed a systematic approach for discriminating between many proposed research ideas based on a well–defined context and criteria. The five “standard” components of the context are the population of interest, the disease burden of interest, geographic limits, time scale and the preferred style of investing with respect to risk. The five “standard” criteria proposed for prioritization between research ideas are answerability, effectiveness, deliverability, maximum potential for disease burden reduction and the effect on equity. However, both the context and the criteria can be flexibly changed to meet the specific needs of each priority–setting exercise. Third, it facilitated consensus development through measuring collective optimism on each component of each research idea among a larger group of experts using a simple

  16. The Promise of Mixed-Methods for Advancing Latino Health Research

    PubMed Central

    Apesoa-Varano, Ester Carolina; Hinton, Ladson

    2015-01-01

    Mixed-methods research in the social sciences has been conducted for quite some time. More recently, mixed-methods have become popular in health research, with the National Institutes of Health leading the impetus to fund studies that implement such an approach. The public health issues facing us today are great and they range from policy and other macro-level issues, to systems level problems to individuals' health behaviors. For Latinos, who are projected to become the largest minority group bearing a great deal of the burden of social inequality in the U.S., it is important to understand the deeply-rooted nature of these health disparities in order to close the gap in health outcomes. Mixed-methodology thus holds promise for advancing research on Latino heath by tackling health disparities from a variety of standpoints and approaches. The aim of this manuscript is to provide two examples of mixed methods research, each of which addresses a health topic of considerable importance to older Latinos and their families. These two examples will illustrate a) the complementary use of qualitative and quantitative methods to advance health of older Latinos in an area that is important from a public health perspective, and b) the “translation” of findings from observational studies (informed by social science and medicine) to the development and testing of interventions. PMID:23996325

  17. Advanced Methods in Meta-Analytic Research: Applications and Implications for Rehabilitation Counseling Research

    ERIC Educational Resources Information Center

    Rosenthal, David A.; Hoyt, William T.; Ferrin, James M.; Miller, Susan; Cohen, Nicholas D.

    2006-01-01

    Over the past 25 years, meta-analysis has assumed a significant role in the synthesis of counseling and psychotherapy research through the evaluation and interpretation of the results of multiple studies. An examination of four widely recognized rehabilitation counseling journals, however, reveals that only one meta-analysis (Bolton & Akridge,…

  18. Integrating Advanced High School Chemistry Research with Organic Chemistry and Instrumental Methods of Analysis

    ERIC Educational Resources Information Center

    Kennedy, Brian J.

    2008-01-01

    This paper describes and discusses the unique chemistry course opportunities beyond the advanced placement-level available at a science and technology magnet high school. Students may select entry-level courses such as honors and advanced placement chemistry; they may also take electives in organic chemistry with instrumental methods of analysis;…

  19. Advances in the Use of Neuroscience Methods in Research on Learning and Instruction

    ERIC Educational Resources Information Center

    De Smedt, Bert

    2014-01-01

    Cognitive neuroscience offers a series of tools and methodologies that allow researchers in the field of learning and instruction to complement and extend the knowledge they have accumulated through decades of behavioral research. The appropriateness of these methods depends on the research question at hand. Cognitive neuroscience methods allow…

  20. Resampling Methods Revisited: Advancing the Understanding and Applications in Educational Research

    ERIC Educational Resources Information Center

    Bai, Haiyan; Pan, Wei

    2008-01-01

    Resampling methods including randomization test, cross-validation, the jackknife and the bootstrap are widely employed in the research areas of natural science, engineering and medicine, but they lack appreciation in educational research. The purpose of the present review is to revisit and highlight the key principles and developments of…

  1. Applying knowledge-anchored hypothesis discovery methods to advance clinical and translational research: the OAMiner project

    PubMed Central

    Jackson, Rebecca D; Best, Thomas M; Borlawsky, Tara B; Lai, Albert M; James, Stephen; Gurcan, Metin N

    2012-01-01

    The conduct of clinical and translational research regularly involves the use of a variety of heterogeneous and large-scale data resources. Scalable methods for the integrative analysis of such resources, particularly when attempting to leverage computable domain knowledge in order to generate actionable hypotheses in a high-throughput manner, remain an open area of research. In this report, we describe both a generalizable design pattern for such integrative knowledge-anchored hypothesis discovery operations and our experience in applying that design pattern in the experimental context of a set of driving research questions related to the publicly available Osteoarthritis Initiative data repository. We believe that this ‘test bed’ project and the lessons learned during its execution are both generalizable and representative of common clinical and translational research paradigms. PMID:22647689

  2. Advancing empirical resilience research.

    PubMed

    Kalisch, Raffael; Müller, Marianne B; Tüscher, Oliver

    2015-01-01

    We are delighted by the broad, intense, and fruitful discussion in reaction to our target article. A major point we take from the many comments is a prevailing feeling in the research community that we need significantly and urgently to advance resilience research, both by sharpening concepts and theories and by conducting empirical studies at a much larger scale and with a much more extended and sophisticated methodological arsenal than is the case currently. This advancement can be achieved only in a concerted international collaborative effort. In our response, we try to argue that an explicitly atheoretical, purely observational definition of resilience and a transdiagnostic, quantitative study framework can provide a suitable basis for empirically testing different competing resilience theories (sects. R1, R2, R6, R7). We are confident that it should be possible to unite resilience researchers from different schools, including from sociology and social psychology, behind such a pragmatic and theoretically neutral research strategy. In sections R3 to R5, we further specify and explain the positive appraisal style theory of resilience (PASTOR). We defend PASTOR as a comparatively parsimonious and translational theory that makes sufficiently concrete predictions to be evaluated empirically. PMID:26815844

  3. NASA advanced propeller research

    NASA Technical Reports Server (NTRS)

    Groeneweg, John F.; Bober, Lawrence J.

    1988-01-01

    Acoustic and aerodynamic research at NASA Lewis Research Center on advanced propellers is reviewed including analytical and experimental results on both single and counterrotation. Computational tools used to calculate the detailed flow and acoustic fields are described along with wind tunnel tests to obtain data for code verification. Results from two kinds of experiments are reviewed: (1) performance and near field noise at cruise conditions as measured in the NASA Lewis 8- by 6-foot Wind Tunnel; and (2) far field noise and performance for takeoff/approach conditions as measured in the NASA Lewis 9- by 15-foot Anechoic Wind Tunnel. Detailed measurements of steady blade surface pressures are described along with vortex flow phenomena at off-design conditions. Near field noise at cruise is shown to level out or decrease as tip relative Mach number is increased beyond 1.15. Counterrotation interaction noise is shown to be a dominant source at takeoff but a secondary source at cruise. Effects of unequal rotor diameters and rotor-to-rotor spacing on interaction noise are also illustrated. Comparisons of wind tunnel acoustic measurements to flight results are made. Finally, some future directions in advanced propeller research such as swirl recovery vanes, higher sweep, forward sweep, and ducted propellers are discussed.

  4. NASA Advanced Propeller Research

    NASA Technical Reports Server (NTRS)

    Groeneweg, John F.; Bober, Lawrence J.

    1988-01-01

    Acoustic and aerodynamic research at NASA Lewis Research Center on advanced propellers is reviewed including analytical and experimental results on both single and counterrotation. Computational tools used to calculate the detailed flow and acoustic i e l d s a r e described along with wind tunnel tests to obtain data for code verification . Results from two kinds of experiments are reviewed: ( 1 ) performance and near field noise at cruise conditions as measured in the NASA Lewis 8-by 6-Foot Wind Tunnel and ( 2 ) farfield noise and performance for takeoff/approach conditions as measured in the NASA Lewis 9-by 15-Font Anechoic Wind Tunnel. Detailed measurements of steady blade surface pressures are described along with vortex flow phenomena at off design conditions . Near field noise at cruise is shown to level out or decrease as tip relative Mach number is increased beyond 1.15. Counterrotation interaction noise is shown to be a dominant source at take off but a secondary source at cruise. Effects of unequal rotor diameters and rotor-to-rotor spacing on interaction noise a real so illustrated. Comparisons of wind tunnel acoustic measurements to flight results are made. Finally, some future directions in advanced propeller research such as swirl recovery vanes, higher sweep, forward sweep, and ducted propellers are discussed.

  5. [Research advances in dendrochronology].

    PubMed

    Fang, Ke-Yan; Chen, Qiu-Yan; Liu, Chang-Zhi; Cao, Chun-Fu; Chen, Ya-Jun; Zhou, Fei-Fei

    2014-07-01

    Tree-ring studies in China have achieved great advances since the 1990s, particularly for the dendroclimatological studies which have made some influence around the world. However, because of the uneven development, limited attention has been currently paid on the other branches of dendrochronology. We herein briefly compared the advances of dendrochronology in China and of the world and presented suggestions on future dendrochronological studies. Large-scale tree-ring based climate reconstructions in China are highly needed by employing mathematical methods and a high quality tree-ring network of the ring-width, density, stable isotope and wood anatomy. Tree-ring based field climate reconstructions provide potentials on explorations of climate forcings during the reconstructed periods via climate diagnosis and process simulation.

  6. [Research advances in dendrochronology].

    PubMed

    Fang, Ke-Yan; Chen, Qiu-Yan; Liu, Chang-Zhi; Cao, Chun-Fu; Chen, Ya-Jun; Zhou, Fei-Fei

    2014-07-01

    Tree-ring studies in China have achieved great advances since the 1990s, particularly for the dendroclimatological studies which have made some influence around the world. However, because of the uneven development, limited attention has been currently paid on the other branches of dendrochronology. We herein briefly compared the advances of dendrochronology in China and of the world and presented suggestions on future dendrochronological studies. Large-scale tree-ring based climate reconstructions in China are highly needed by employing mathematical methods and a high quality tree-ring network of the ring-width, density, stable isotope and wood anatomy. Tree-ring based field climate reconstructions provide potentials on explorations of climate forcings during the reconstructed periods via climate diagnosis and process simulation. PMID:25345035

  7. [Research advances in ecosystem flux].

    PubMed

    Zhang, Xudong; Peng, Zhenhua; Qi, Lianghua; Zhou, Jinxing

    2005-10-01

    To develop the long-term localized observation and investigation on ecosystem flux is of great importance. On the basis of generalizing the concepts and connotations of ecosystem flux, this paper introduced the construction and development histories of Global Flux Networks, Regional Flux Networks (Ameri-Flux, Euro-Flux and Asia-Flux) and China-Flux, as well as the main methodologies, including micrometeorological methods (such as eddy correlation method, mass balance method, energy balance method and air dynamic method)and chamber methods (static and dynamic chamber methods), and their basic operation principles. The research achievements, approaches and advances of CO2, N2O, CH4, and heat fluxes in forest ecosystem, farmland ecosystem, grassland ecosystem and water ecosystem were also summarized. In accordance with the realities and necessities of ecosystem flux research in China, some suggestions and prospects were put forward.

  8. [Research advances on DNA extraction methods from peripheral blood mononuclear cells].

    PubMed

    Wang, Xiao-Ying; Yu, Chen-Xi

    2014-10-01

    DNA extraction is a basic technology of molecular biology. The purity and the integrality of DNA structure are necessary for different experiments of gene engineering. As commonly used materials in the clinical detection, the fast, efficient isolation and extraction of genomic DNA from peripheral blood mononuclear cells is very important for the inspection and analysis of clinical blood. At present, there are many methods for extracting DNA, such as phenol-chloroform method, salting out method, centrifugal adsorption column chromatography method (artificial methods), magnetic beads (semi-automatic method) and DNA extraction kit. In this article, a brief review of the principle for existing DNA blood extraction method, the specific steps and the assessment of the specific methods briefly are summarized.

  9. Advanced desiccant materials research

    SciTech Connect

    Czanderna, A.W.; Thomas, T.M.

    1986-05-01

    The long-range goal of this task is to understand the role of surface phenomena in desiccant cooling materials. The background information includes a brief introduction to desiccant cooling systems (DCS) and the role of the desiccant as a system component. The purpose, background, rationale, and long-term technical approach for studying advanced desiccant materials are then treated. Experimental methods for measuring water vapor sorption by desiccants are described, and the rationale is then given for choosing a quartz crystal microbalance (QCM) for measuring sorption isotherms, rates, and cyclic stability. Background information is given about the QCM, including the quartz crystal resonator itself, the support structure for the quartz crystal, and the advantages and limitations of a QCM. The apparatus assembled and placed into operation during CY 1985 is described. The functions of the principal components of the equipment, i.e., the QCM, vacuum system, pressure gauges, residual gas analyzer, constant temperature bath, and data acquisition system, are described as they relate to the water vapor sorption measurements now under way. The criteria for narrowing the potential candidates as advanced desiccant materials for the initial studies are given. Also given is a list of 20 principal candidate materials identified based on the criteria and data available in the literature.

  10. Data Mining and Domain Knowledge: An Exploration of Methods to Advance Medical Research

    ERIC Educational Resources Information Center

    Engle, Kelley M.

    2013-01-01

    Researchers in the medical domain consider the double-blind placebo controlled clinical trial the gold standard. The data for these clinical trials are collected for a specifically defined hypothesis and there is very little in the realm of secondary data analyses conducted. The underlying purpose of this work is to demonstrate the value and…

  11. Advanced propeller research

    NASA Technical Reports Server (NTRS)

    Groeneweg, John F.; Bober, Lawrence J.

    1987-01-01

    Resent results of aerodynamic and acoustic research on both single and counter-rotation propellers are reviewed. Data and analytical results are presented for three propellers: SR-7A, the single rotation design used in the NASA Propfan Test Assessment (PTA); and F7-A7, the 8+8 counterrotating design used in the proof-of-concept Unducted Fan (UDF) engine. In addition to propeller efficiencies, cruise and takeoff noise, and blade pressure data, off-design phenomena involving formation of leading edge vortices are described. Aerodynamic and acoustic computational results derived from three-dimensional Euler and acoustic radiation codes are presented. Research on unsteady flows, which are particularly important for understanding counterrotation interaction noise, unsteady loading effects on acoustics, and flutter or forced response is described. The first results of three-dimensional unsteady Euler solutions are illustrated for a single rotation propeller at an angle of attack and for a counterrotation propeller. Basic experimental and theoretical results from studies of the unsteady aerodynamics of oscillating cascades are outlined. Finally, advanced concepts involving swirl recovery vanes and ultra bypass ducted propellers are discussed.

  12. Research on advanced spacecraft

    NASA Astrophysics Data System (ADS)

    Iwata, Tsutomu; Etou, Takao; Imai, Ryouichi; Oota, Kazuo; Kaneko, Yutaka; Maeda, Toshihide; Takano, Yutaka

    1992-08-01

    Engineering test satellite systems to validate element technologies required for spacecraft composing advanced space infrastructures are studied. Case studies are conducted on element technologies for diversified manned space technology and the outline of the engineering test satellite systems is demonstrated. Debris observing systems, their debris collection and retrieval methods which are being reviewed in many countries are examined. Technical problems are picked up, and the fundamental concept of experiment satellites is determined. Missions deemed to be suitable for micro-satellites and various civil on-ground technologies focusing on electronic technology applicable to them are picked up. Functions of extravehicular operation systems required by the missions, and fundamental concept of the systems and subsystems are made clear. Missions to which artificial gravity experiment satellites that are effective are examined and preparatory review is conducted on artificial gravity generation methods, methods to retrieve experiment equipment and samples, and outline of the satellite systems. Technical problems of engineering test satellites to validate on-orbit cryogenic propellant storage and transportation technologies are picked up and the fundamental concept of the satellites are determined. A review is conducted on electrical propulsion Orbit Transfer Vehicle (OTV) technology satellite to validate fundamental technology for large electrical propulsion engine and electrical propulsion engine OTV operation technology, and to pick up problems on the orbit of electrical propulsion OTV.

  13. Enabling Advanced Wind-Tunnel Research Methods Using the NASA Langley 12-Foot Low Speed Tunnel

    NASA Technical Reports Server (NTRS)

    Busan, Ronald C.; Rothhaar, Paul M.; Croom, Mark A.; Murphy, Patrick C.; Grafton, Sue B.; O-Neal, Anthony W.

    2014-01-01

    Design of Experiment (DOE) testing methods were used to gather wind tunnel data characterizing the aerodynamic and propulsion forces and moments acting on a complex vehicle configuration with 10 motor-driven propellers, 9 control surfaces, a tilt wing, and a tilt tail. This paper describes the potential benefits and practical implications of using DOE methods for wind tunnel testing - with an emphasis on describing how it can affect model hardware, facility hardware, and software for control and data acquisition. With up to 23 independent variables (19 model and 2 tunnel) for some vehicle configurations, this recent test also provides an excellent example of using DOE methods to assess critical coupling effects in a reasonable timeframe for complex vehicle configurations. Results for an exploratory test using conventional angle of attack sweeps to assess aerodynamic hysteresis is summarized, and DOE results are presented for an exploratory test used to set the data sampling time for the overall test. DOE results are also shown for one production test characterizing normal force in the Cruise mode for the vehicle.

  14. Advancing Research Methods to Detect Impact of Climate Change on Health in Grand'Anse, Haiti

    NASA Astrophysics Data System (ADS)

    Barnhart, S.; Coq, R. N.; Frederic, R.; DeRiel, E.; Camara, H.; Barnhart, K. R.

    2013-12-01

    Haiti is considered particularly vulnerable to the effects of climate change, but directly linking climate change to health effects is limited by the lack of robust data and the multiple determinants of health. Worsening storms and rising temperatures in this rugged country with high poverty is likely to adversely affect economic activity, population growth and other determinants of health. For the past two years, the Univ. of Washington has supported the public hospital in the department of Grand'Anse. Grand'Anse, a relatively contained region in SW Haiti with an area of 11,912 km2, is predominantly rural with a population of 350,000 and is bounded to the south by peaks up to 2,347 m. Grand'Anse would serve as an excellent site to assess the interface between climate change and health. The Demographic and Health Survey (DHS) shows health status is low relative to other countries. Estimates of climate change for Jeremie, the largest city in Grand'Anse, predict the mean monthly temperature will increase from 26.1 to 27.3 oC while mean monthly rainfall will decrease from 80.5 to 73.5 mm over the next 60 years. The potential impact of these changes ranges from threatening food security to greater mortality. Use of available secondary data such as indicators of climate change and DHS health status are not likely to offer sufficient resolution to detect positive or negative impacts of climate change on health. How might a mixed methods approach incorporating secondary data and quantitative and qualitative survey data on climate, economic activity, health and determinants of health address the hypothesis: Climate change does not adversely affect health? For example, in Haiti most women deliver at home. Maternal mortality is high at 350 deaths/100,000 deliveries. This compares to deliveries in facilities where the median rate is less than 100/100,000. Thus, maternal mortality is closely linked to access to health care in this rugged mountainous country. Climate change

  15. Advanced epidemiologic and analytical methods.

    PubMed

    Albanese, E

    2016-01-01

    Observational studies are indispensable for etiologic research, and are key to test life-course hypotheses and improve our understanding of neurologic diseases that have long induction and latency periods. In recent years a plethora of advanced design and analytic techniques have been developed to strengthen the robustness and ultimately the validity of the results of observational studies, and to address their inherent proneness to bias. It is the responsibility of clinicians and researchers to critically appraise and appropriately contextualize the findings of the exponentially expanding scientific literature. This critical appraisal should be rooted in a thorough understanding of advanced epidemiologic methods and techniques commonly used to formulate and test relevant hypotheses and to keep bias at bay. PMID:27637951

  16. Advancing neurosurgery through translational research.

    PubMed

    Lacey, Claire; Sutherland, Garnette

    2013-01-01

    Every year, the number of published research articles increases significantly. However, many potentially useful ideas are lost in this flood of data. Translational research provides a framework through which investigators or laboratories can maximize the likelihood that the product of their research will be adopted in medical practice. There are 2 recognizable models of translation appropriate for the majority of research: investigator driven and industry enabled. Investigator-driven research has more range because it does not have to consider the profit margin of research, but it is a slow process. The industry-enabled model accelerates the translational research process through the power of industry funding but is interested primarily in products with potential for profit. Two cases are examined to illustrate different methods of partnering with industry. IMRIS is a company founded by investigators to distribute intraoperative magnetic resonance imaging technology based on a movable high-field magnet. It took 7 years for IMRIS to make its first sale, but it is now a successful company. With neuroArm, a surgical robot, investigators decided to sell the intellectual property to an established company to ensure successful global commercialization. Translational research advances medicine by creating and distributing effective solutions to contemporary problems. PMID:23254806

  17. Advancing Scientific Research in Education

    ERIC Educational Resources Information Center

    Towne, Lisa, Ed.; Wise, Lauress L., Ed.; Winters, Tina M., Ed.

    2005-01-01

    The title of this report reveals its purpose precisely: to spur actions that will advance scientific research in education. The recommendations for accomplishing this goal, detailed in this report, build on the National Research Council (NRC) report "Scientific Research in Education" (National Research Council, 2002). That report offers an…

  18. Advances in phytase research.

    PubMed

    Mullaney, E J; Daly, C B; Ullah, A H

    2000-01-01

    -ray crystallographic analysis has been initiated, no enzymatic mechanism has been proposed. Perhaps the pivotal event in the last century that created the need for phytase was the development of modern fertilizers after the Second World War. This fostered a transformation in agriculture and a tremendous increase in feed-grain production. These large quantities of cereals and meal in turn led to the transition of one segment of agriculture into "animal agriculture," with their its animal production capability. The huge volumes of manure spawned by these production units in time exceeded both the capacity of their crops and crop lands to utilize or bind the increased amount of phosphorus. Nutrient runoff from this land has now been linked to a number of blooms of toxin-producing microbes. Fish kills associated with these blooms have attracted public and governmental concern, as well as greater interest in phytase as a means to reduce this phosphorus pollution. Phytase research efforts now are focused on the engineering of an improved enzyme. Improved heat tolerance to allow the enzyme to survive the brief period of elevated temperature during the pelletization process is seen as an essential step to lower its cost in animal feed. Information from the X-ray crystal structure of phytase is also relevant to improving the pH optimum, substrate specificity, and enzyme stability. Several studies on new strategies that involve synergistic interactions between phytase and other hydrolytic enzymes have shown positive results. Further reduction in the production cost of phytase is also being pursued. Several studies have already investigated the use of various yeast expression systems as an alternative to the current production method for phytase using overexpression in filamentous fungi. Expression in plants is underway as a means to commercially produce phytase, as in biofarming in which plants such as alfalfa are used as "bioreactors," and also by developing plant cultivars that would produce

  19. Advances in phytase research.

    PubMed

    Mullaney, E J; Daly, C B; Ullah, A H

    2000-01-01

    -ray crystallographic analysis has been initiated, no enzymatic mechanism has been proposed. Perhaps the pivotal event in the last century that created the need for phytase was the development of modern fertilizers after the Second World War. This fostered a transformation in agriculture and a tremendous increase in feed-grain production. These large quantities of cereals and meal in turn led to the transition of one segment of agriculture into "animal agriculture," with their its animal production capability. The huge volumes of manure spawned by these production units in time exceeded both the capacity of their crops and crop lands to utilize or bind the increased amount of phosphorus. Nutrient runoff from this land has now been linked to a number of blooms of toxin-producing microbes. Fish kills associated with these blooms have attracted public and governmental concern, as well as greater interest in phytase as a means to reduce this phosphorus pollution. Phytase research efforts now are focused on the engineering of an improved enzyme. Improved heat tolerance to allow the enzyme to survive the brief period of elevated temperature during the pelletization process is seen as an essential step to lower its cost in animal feed. Information from the X-ray crystal structure of phytase is also relevant to improving the pH optimum, substrate specificity, and enzyme stability. Several studies on new strategies that involve synergistic interactions between phytase and other hydrolytic enzymes have shown positive results. Further reduction in the production cost of phytase is also being pursued. Several studies have already investigated the use of various yeast expression systems as an alternative to the current production method for phytase using overexpression in filamentous fungi. Expression in plants is underway as a means to commercially produce phytase, as in biofarming in which plants such as alfalfa are used as "bioreactors," and also by developing plant cultivars that would produce

  20. Advances in Electrophysiological Research

    PubMed Central

    Kamarajan, Chella; Porjesz, Bernice

    2015-01-01

    Electrophysiological measures of brain function are effective tools to understand neurocognitive phenomena and sensitive indicators of pathophysiological processes associated with various clinical conditions, including alcoholism. Individuals with alcohol use disorder (AUD) and their high-risk offspring have consistently shown dysfunction in several electrophysiological measures in resting state (i.e., electroencephalogram) and during cognitive tasks (i.e., event-related potentials and event-related oscillations). Researchers have recently developed sophisticated signal-processing techniques to characterize different aspects of brain dynamics, which can aid in identifying the neural mechanisms underlying alcoholism and other related complex disorders. These quantitative measures of brain function also have been successfully used as endophenotypes to identify and help understand genes associated with AUD and related disorders. Translational research also is examining how brain electrophysiological measures potentially can be applied to diagnosis, prevention, and treatment. PMID:26259089

  1. Advanced Remote Sensing Research

    USGS Publications Warehouse

    Slonecker, Terrence; Jones, John W.; Price, Susan D.; Hogan, Dianna

    2008-01-01

    'Remote sensing' is a generic term for monitoring techniques that collect information without being in physical contact with the object of study. Overhead imagery from aircraft and satellite sensors provides the most common form of remotely sensed data and records the interaction of electromagnetic energy (usually visible light) with matter, such as the Earth's surface. Remotely sensed data are fundamental to geographic science. The Eastern Geographic Science Center (EGSC) of the U.S. Geological Survey (USGS) is currently conducting and promoting the research and development of three different aspects of remote sensing science: spectral analysis, automated orthorectification of historical imagery, and long wave infrared (LWIR) polarimetric imagery (PI).

  2. ADVANCED GAS TURBINE SYSTEMS RESEARCH

    SciTech Connect

    Unknown

    2000-01-01

    The activities of the Advanced Gas Turbine Systems Research (AGRSR) program are described in the quarterly report. The report is divided into discussions of Membership, Administration, Technology Transfer (Workshop/Education) and Research. Items worthy of note are presented in extended bullet format following the appropriate heading.

  3. ADVANCED GAS TURBINE SYSTEMS RESEARCH

    SciTech Connect

    Unknown

    2002-04-01

    The activities of the Advanced Gas Turbine Systems Research (AGTSR) program for this reporting period are described in this quarterly report. The report is divided into discussions of Membership, Administration, Technology Transfer (Workshop/Education), Research and Miscellaneous Related Activity. Items worthy of note are presented in extended bullet format following the appropriate heading.

  4. ADVANCED GAS TURBINE SYSTEMS RESEARCH

    SciTech Connect

    Unknown

    2002-02-01

    The activities of the Advanced Gas Turbine Systems Research (AGTSR) program for this reporting period are described in this quarterly report. The report is divided into discussions of Membership, Administration, Technology Transfer (Workshop/Education), Research and Miscellaneous Related Activity. Items worthy of note are presented in extended bullet format following the appropriate heading.

  5. Advancing Scientific Research in Education

    ERIC Educational Resources Information Center

    Towne, Lisa, Ed.; Wise, Lauress L., Ed.; Winters, Tina M., Ed.

    2004-01-01

    Transforming education into an evidence-based field depends in no small part on a strong base of scientific knowledge to inform educational policy and practice. Advancing Scientific Research in Education makes select recommendations for strengthening scientific education research and targets federal agencies, professional associations, and…

  6. Advanced propeller research

    NASA Technical Reports Server (NTRS)

    Groeneweg, John F.; Bober, Lawrence J.

    1990-01-01

    Recent results of aerodynamic and acoustic research on both single rotation and counterrotation propellers are reviewed. Data and analytical results are presented for three propellers: SR-7A, the single rotation design used in the NASA Propfan Test Assessment (PTA) flight program; CRP-X1, the initial 5+5 Hamilton Standard counterrotating design; and F7-A7, the 8+8 counterrotating G.E. design used in the proof of concept Unducted Fan (UDF) engine. In addition to propeller efficiencies, cruise and takeoff noise, and blade pressure data, off-design phenomena involving formation of leading edge vortexes are described. Aerodynamic and acoustic computational results derived from 3-D Euler and acoustic radiation codes are presented. Research on unsteady flows which are particularly important for understanding counterrotation interaction noise, unsteady loading effects on acoustics, and flutter or forced response is described. The first results of 3-D unsteady Euler solutions are illustrated for a single rotation propeller at angle of attack and for a counterrotation propeller. Basic experimental and theoretical results from studies on the unsteady aerodynamics of oscillating cascades are outlined.

  7. Advanced ion thruster research

    NASA Technical Reports Server (NTRS)

    Wilbur, P. J.

    1984-01-01

    A simple model describing the discharge chamber performance of high strength, cusped magnetic field ion thrusters is developed. The model is formulated in terms of the energy cost of producing ions in the discharge chamber and the fraction of ions produced in the discharge chamber that are extracted to form the ion beam. The accuracy of the model is verified experimentally in a series of tests wherein the discharge voltage, propellant, grid transparency to neutral atoms, beam diameter and discharge chamber wall temperature are varied. The model is exercised to demonstrate what variations in performance might be expected by varying discharge chamber parameters. The results of a study of xenon and argon orificed hollow cathodes are reported. These results suggest that a hollow cathode model developed from research conducted on mercury cathodes can also be applied to xenon and argon. Primary electron mean free paths observed in argon and xenon cathodes that are larger than those found in mercury cathodes are identified as a cause of performance differences between mercury and inert gas cathodes. Data required as inputs to the inert gas cathode model are presented so it can be used as an aid in cathode design.

  8. ISAAC Advanced Composites Research Testbed

    NASA Technical Reports Server (NTRS)

    Wu, K. Chauncey; Stewart, Brian K.; Martin, Robert A.

    2014-01-01

    The NASA Langley Research Center is acquiring a state-of-art composites fabrication capability to support the Center's advanced research and technology mission. The system introduced in this paper is named ISAAC (Integrated Structural Assembly of Advanced Composites). The initial operational capability of ISAAC is automated fiber placement, built around a commercial system from Electroimpact, Inc. that consists of a multi-degree of freedom robot platform, a tool changer mechanism, and a purpose-built fiber placement end effector. Examples are presented of the advanced materials, structures, structural concepts, fabrication processes and technology development that may be enabled using the ISAAC system. The fiber placement end effector may be used directly or with appropriate modifications for these studies, or other end effectors with different capabilities may either be bought or developed with NASA's partners in industry and academia.

  9. Translational research on advanced therapies.

    PubMed

    Belardelli, Filippo; Rizza, Paola; Moretti, Franca; Carella, Cintia; Galli, Maria Cristina; Migliaccio, Giovanni

    2011-01-01

    Fostering translational research of advanced therapies has become a major priority of both scientific community and national governments. Advanced therapy medicinal products (ATMP) are a new medicinal product category comprising gene therapy and cell-based medicinal products as well as tissue engineered medicinal products. ATMP development opens novel avenues for therapeutic approaches in numerous diseases, including cancer and neurodegenerative and cardiovascular diseases. However, there are important bottlenecks for their development due to the complexity of the regulatory framework, the high costs and the needs for good manufacturing practice (GMP) facilities and new end-points for clinical experimentation. Thus, a strategic cooperation between different stakeholders (academia, industry and experts in regulatory issues) is strongly needed. Recently, a great importance has been given to research infrastructures dedicated to foster translational medicine of advanced therapies. Some ongoing European initiatives in this field are presented and their potential impact is discussed.

  10. Probe diagnostics in the far scrape-off layer plasma of Korea Superconducting Tokamak Advanced Research tokamak using a sideband harmonic method

    SciTech Connect

    Kim, Dong-Hwan; Hong, Suk-Ho; Park, Il-Seo; Lee, Hyo-Chang; Kang, Hyun-Ju; Chung, Chin-Wook

    2015-12-15

    Plasma characteristics in the far scrape-off layer region of tokamak play a crucial role in the stable plasma operation and its sustainability. Due to the huge facility, electrical diagnostic systems to measure plasma properties have extremely long cable length resulting in large stray current. To overcome this problem, a sideband harmonic method was applied to the Korea Superconducting Tokamak Advanced Research tokamak plasma. The sideband method allows the measurement of the electron temperature and the plasma density without the effect of the stray current. The measured plasma densities are compared with those from the interferometer, and the results show reliability of the method.

  11. Probe diagnostics in the far scrape-off layer plasma of Korea Superconducting Tokamak Advanced Research tokamak using a sideband harmonic method

    NASA Astrophysics Data System (ADS)

    Kim, Dong-Hwan; Hong, Suk-Ho; Park, Il-Seo; Lee, Hyo-Chang; Kang, Hyun-Ju; Chung, Chin-Wook

    2015-12-01

    Plasma characteristics in the far scrape-off layer region of tokamak play a crucial role in the stable plasma operation and its sustainability. Due to the huge facility, electrical diagnostic systems to measure plasma properties have extremely long cable length resulting in large stray current. To overcome this problem, a sideband harmonic method was applied to the Korea Superconducting Tokamak Advanced Research tokamak plasma. The sideband method allows the measurement of the electron temperature and the plasma density without the effect of the stray current. The measured plasma densities are compared with those from the interferometer, and the results show reliability of the method.

  12. Probe diagnostics in the far scrape-off layer plasma of Korea Superconducting Tokamak Advanced Research tokamak using a sideband harmonic method.

    PubMed

    Kim, Dong-Hwan; Hong, Suk-Ho; Park, Il-Seo; Lee, Hyo-Chang; Kang, Hyun-Ju; Chung, Chin-Wook

    2015-12-01

    Plasma characteristics in the far scrape-off layer region of tokamak play a crucial role in the stable plasma operation and its sustainability. Due to the huge facility, electrical diagnostic systems to measure plasma properties have extremely long cable length resulting in large stray current. To overcome this problem, a sideband harmonic method was applied to the Korea Superconducting Tokamak Advanced Research tokamak plasma. The sideband method allows the measurement of the electron temperature and the plasma density without the effect of the stray current. The measured plasma densities are compared with those from the interferometer, and the results show reliability of the method.

  13. Probe diagnostics in the far scrape-off layer plasma of Korea Superconducting Tokamak Advanced Research tokamak using a sideband harmonic method.

    PubMed

    Kim, Dong-Hwan; Hong, Suk-Ho; Park, Il-Seo; Lee, Hyo-Chang; Kang, Hyun-Ju; Chung, Chin-Wook

    2015-12-01

    Plasma characteristics in the far scrape-off layer region of tokamak play a crucial role in the stable plasma operation and its sustainability. Due to the huge facility, electrical diagnostic systems to measure plasma properties have extremely long cable length resulting in large stray current. To overcome this problem, a sideband harmonic method was applied to the Korea Superconducting Tokamak Advanced Research tokamak plasma. The sideband method allows the measurement of the electron temperature and the plasma density without the effect of the stray current. The measured plasma densities are compared with those from the interferometer, and the results show reliability of the method. PMID:26724028

  14. Advanced diagnostic methods in avionics

    NASA Astrophysics Data System (ADS)

    Popyack, Leonard Joseph, Jr.

    Advanced diagnostic systems facilitate further enhancement of reliability and safety of modern aircraft. Unlike classical reliability analyses, addressing specific classes of systems or devices, this research is aimed at the development of methods for assessment of the individual reliability characteristics of particular system components subjected to their unique histories of operational conditions and exposure to adverse environmental factors. Individual reliability characteristics are crucial for the implementation of the most efficient maintenance practice of flight-critical system components, known as "condition-based maintenance." The dissertation presents hardware and software aspects of a computer-based system, Time-Stress Monitoring Device, developed to record, store, and analyze raw data characterizing operational and environmental conditions and performance of electro-mechanical flight control system components and aircraft electronics (avionics). Availability of this data facilitates formulation and solution of such diagnostic problems as estimation of the probability of failure and life expectancy of particular components, failure detection, identification, and prediction. Statistical aspects of system diagnostics are considered. Particular diagnostic procedures utilizing cluster analysis, Bayes' technique, and regression analysis are formulated. Laboratory and simulation experiment that verify the obtained results are provided.

  15. Advanced Component Research Facility (ACRES)

    SciTech Connect

    Bohn, M.

    1980-07-01

    A detailed description of the SERI Advanced Component Research Facility (ACRES) is given. Background information explicates the facility's history, developed around the two Omnium-G parabolic dish concentrators. The Omnium-G concentrators and electrical power plant are described. The purpose and a detailed descripttion of ACRES is also given. Included is a description of the measurement capabilities, the controls, and each component of the facility.

  16. The Truth, the Whole Truth, and Nothing but the Ground-Truth: Methods to Advance Environmental Justice and Researcher-Community Partnerships.

    PubMed

    Sadd, James; Morello-Frosch, Rachel; Pastor, Manuel; Matsuoka, Martha; Prichard, Michele; Carter, Vanessa

    2014-06-01

    Environmental justice advocates often argue that environmental hazards and their health effects vary by neighborhood, income, and race. To assess these patterns and advance preventive policy, their colleagues in the research world often use complex and methodologically sophisticated statistical and geospatial techniques. One way to bridge the gap between the technical work and the expert knowledge of local residents is through community-based participatory research strategies. We document how an environmental justice screening method was coupled with "ground-truthing"-a project in which community members worked with researchers to collect data across six Los Angeles neighborhoods-which demonstrated the clustering of potentially hazardous facilities, high levels of air pollution, and elevated health risks. We discuss recommendations and implications for future research and collaborations between researchers and community-based organizations.

  17. Cost estimating methods for advanced space systems

    NASA Technical Reports Server (NTRS)

    Cyr, Kelley

    1988-01-01

    The development of parametric cost estimating methods for advanced space systems in the conceptual design phase is discussed. The process of identifying variables which drive cost and the relationship between weight and cost are discussed. A theoretical model of cost is developed and tested using a historical data base of research and development projects.

  18. Research on advanced transportation systems

    NASA Astrophysics Data System (ADS)

    Nagai, Hirokazu; Hashimoto, Ryouhei; Nosaka, Masataka; Koyari, Yukio; Yamada, Yoshio; Noda, Keiichirou; Shinohara, Suetsugu; Itou, Tetsuichi; Etou, Takao; Kaneko, Yutaka

    1992-08-01

    An overview of the researches on advanced space transportation systems is presented. Conceptual study is conducted on fly back boosters with expendable upper stage rocket systems assuming a launch capacity of 30 tons and returning to the launch site by the boosters, and prospect of their feasibility is obtained. Reviews are conducted on subjects as follows: (1) trial production of 10 tons sub scale engines for the purpose of acquiring hardware data and picking up technical problems for full scale 100 tons thrust engines using hydrocarbon fuels; (2) development techniques for advanced liquid propulsion systems from the aspects of development schedule, cost; (3) review of conventional technologies, and common use of component; (4) oxidant switching propulsion systems focusing on feasibility of Liquefied Air Cycle Engine (LACE) and Compressed Air Cycle Engine (CACE); (5) present status of slosh hydrogen manufacturing, storage, and handling; (6) construction of small high speed dynamometer for promoting research on mini pump development; (7) hybrid solid boosters under research all over the world as low-cost and clean propulsion systems; and (8) high performance solid propellant for upper stage and lower stage propulsion systems.

  19. Intermediate/Advanced Research Design and Statistics

    NASA Technical Reports Server (NTRS)

    Ploutz-Snyder, Robert

    2009-01-01

    The purpose of this module is To provide Institutional Researchers (IRs) with an understanding of the principles of advanced research design and the intermediate/advanced statistical procedures consistent with such designs

  20. Advancing Concentrating Solar Power Research (Fact Sheet)

    SciTech Connect

    Not Available

    2014-02-01

    Researchers at the National Renewable Energy Laboratory (NREL) provide scientific, engineering, and analytical expertise to help advance innovation in concentrating solar power (CSP). This fact sheet summarizes how NREL is advancing CSP research.

  1. CSM parallel structural methods research

    NASA Technical Reports Server (NTRS)

    Storaasli, Olaf O.

    1989-01-01

    Parallel structural methods, research team activities, advanced architecture computers for parallel computational structural mechanics (CSM) research, the FLEX/32 multicomputer, a parallel structural analyses testbed, blade-stiffened aluminum panel with a circular cutout and the dynamic characteristics of a 60 meter, 54-bay, 3-longeron deployable truss beam are among the topics discussed.

  2. RESEARCH ADVANCES IN NEUROBLASTOMA IMMUNOTHERAPY.

    PubMed

    Booker, Latania Y; Ishola, Titilope A; Bowen, Kanika A; Chung, Dai H

    2009-05-01

    Neuroblastoma is the third most common pediatric cancer in the United States and is responsible for 15% of pediatric cancer-related deaths. Despite major advances in multimodal therapy, the clinical outcome for several patients remains poor. Due to the desperate need for innovativation and improved success in the treatment and management of neuroblastoma, research interests in immunotherapy have been on the rise in recent years. Current immunotherapeutic approaches under investigation include antibodies targeting the neuroblastoma antigen GD2, cytokine stimulation of immune cells, use of immunocytokine conjugates, radioimmunotherapy, and tumor-primed dendritic cells. Immunotherapy could serve as a safe alternative or adjunct to current therapeutic protocols and would presumptively have fewer deleterious effects making it more favorable to patients.

  3. 32 CFR 37.1210 - Advanced research.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1210 Advanced... technology to new products and processes in a general way. Advanced research is most closely analogous to... 32 National Defense 1 2014-07-01 2014-07-01 false Advanced research. 37.1210 Section...

  4. 32 CFR 37.1210 - Advanced research.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1210 Advanced... technology to new products and processes in a general way. Advanced research is most closely analogous to... 32 National Defense 1 2013-07-01 2013-07-01 false Advanced research. 37.1210 Section...

  5. 32 CFR 37.1210 - Advanced research.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1210 Advanced... technology to new products and processes in a general way. Advanced research is most closely analogous to... 32 National Defense 1 2012-07-01 2012-07-01 false Advanced research. 37.1210 Section...

  6. 32 CFR 37.1210 - Advanced research.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Advanced research. 37.1210 Section 37.1210... research. Research that creates new technology or demonstrates the viability of applying existing technology to new products and processes in a general way. Advanced research is most closely analogous...

  7. 32 CFR 37.1210 - Advanced research.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Advanced research. 37.1210 Section 37.1210... research. Research that creates new technology or demonstrates the viability of applying existing technology to new products and processes in a general way. Advanced research is most closely analogous...

  8. Recent advances in betalain research.

    PubMed

    Strack, Dieter; Vogt, Thomas; Schliemann, Willibald

    2003-02-01

    Betalains replace the anthocyanins in flowers and fruits of plants of most families of the Caryophyllales. Unexpectedly, they were also found in some higher fungi. Whereas the anthocyanin-analogous functions of betalains in flower and fruit colouration are obvious, their role in fungi remains obscure. The nature of newly identified betalains as well as final structure elucidation of earlier putatively described compounds published within the last decade is compiled in this report. Recent advances in research on betalain biosynthesis is also covered, including description of some 'early' reactions, i.e. betalain-specific dopa formation in plants and fungi and extradiolic dopa cleavage in fungi. Work on betalain-specific glucosyltransferases (GTs) has given new insights into the evolution of secondary plant enzymes. It is proposed that these GTs are phylogenetically related to flavonoid GTs. It was found that the decisive steps in betalain biosynthesis, i.e. condensation of the betalain chromophore betalamic acid with cyclo-dopa and amino acids or amines in the respective aldimine formation of the red-violet betacyanins and the yellow betaxanthins, are most likely to be non-enzymatic. Betalains have attracted workers in applied fields because of their use for food colouring and their antioxidant and radical scavenging properties for protection against certain oxidative stress-related disorders. PMID:12620337

  9. Start Up Research Effort in Fluid Mechanics. Advanced Methods for Acoustic and Thrust Benefits for Aircraft Engine Nozzle

    NASA Technical Reports Server (NTRS)

    White, Samuel G.; Gilinsky, Mikhail M.

    1997-01-01

    In accordance with the project plan for the report period in the proposal titled above, HU and FML teams investigated two sets of concepts for reduction of noise and improvement in efficiency for jet exhaust nozzles of aircraft engines and screws for mixers, fans, propellers and boats. The main achievements in the report period are: (a) Publication of the paper in the AIAA Journal, which described our concepts and some results. (b) The Award in the Civil Research and Development Foundation (CRDF) competition. This 2 year grant for Hampton University (HU) and Central AeroHydrodynamic Institute (TSAGI, Moscow, Russia) supports the research implementation under the current NASA FAR grant. (c) Selection for funding by NASA HQ review panel of the Partnership Awards Concept Paper. This two year grant also will support our current FAR grant. (d) Publication of a Mobius Strip concept in NASA Technical Briefs, June, 1996, and a great interest of many industrial companies in this invention. Successful experimental results with the Mobius shaped screw for mixers, which save more than 30% of the electric power by comparison with the standard screws. Creation of the scientific-popular video-film which can be used for commercial and educational purposes. (e) Organization work, joint meetings and discussions of the NASA LARC JNL Team and HU professors and administration for the solution of actual problems and effective work of the Fluid Mechanics Laboratory at Hampton University. In this report the main designs are enumerated. It also contains for both concept sets: (1) the statement of the problem for each design, some results, publications, inventions, patents, our vision for continuation of this research, and (2) present and expected problems in the future.

  10. Advance Organizer Research: One Step Further.

    ERIC Educational Resources Information Center

    Zeitoun, Hassan Hussein

    The purpose of this paper is to: (1) explore some possible explanations for the lack of empirical support of advance organizers; (2) suggest a plan for improving the empirical research on advance organizers; and (3) recommend some further investigations needed in the area of advance organizers. Some explanations for this lack of support are…

  11. Advanced reliability methods - A review

    NASA Astrophysics Data System (ADS)

    Forsyth, David S.

    2016-02-01

    There are a number of challenges to the current practices for Probability of Detection (POD) assessment. Some Nondestructive Testing (NDT) methods, especially those that are image-based, may not provide a simple relationship between a scalar NDT response and a damage size. Some damage types are not easily characterized by a single scalar metric. Other sensing paradigms, such as structural health monitoring, could theoretically replace NDT but require a POD estimate. And the cost of performing large empirical studies to estimate POD can be prohibitive. The response of the research community has been to develop new methods that can be used to generate the same information, POD, in a form that can be used by engineering designers. This paper will highlight approaches to image-based data and complex defects, Model Assisted POD estimation, and Bayesian methods for combining information. This paper will also review the relationship of the POD estimate, confidence bounds, tolerance bounds, and risk assessment.

  12. Simulation methods for advanced scientific computing

    SciTech Connect

    Booth, T.E.; Carlson, J.A.; Forster, R.A.

    1998-11-01

    This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The objective of the project was to create effective new algorithms for solving N-body problems by computer simulation. The authors concentrated on developing advanced classical and quantum Monte Carlo techniques. For simulations of phase transitions in classical systems, they produced a framework generalizing the famous Swendsen-Wang cluster algorithms for Ising and Potts models. For spin-glass-like problems, they demonstrated the effectiveness of an extension of the multicanonical method for the two-dimensional, random bond Ising model. For quantum mechanical systems, they generated a new method to compute the ground-state energy of systems of interacting electrons. They also improved methods to compute excited states when the diffusion quantum Monte Carlo method is used and to compute longer time dynamics when the stationary phase quantum Monte Carlo method is used.

  13. Research Methods in Education

    ERIC Educational Resources Information Center

    Check, Joseph; Schutt, Russell K.

    2011-01-01

    "Research Methods in Education" introduces research methods as an integrated set of techniques for investigating questions about the educational world. This lively, innovative text helps students connect technique and substance, appreciate the value of both qualitative and quantitative methodologies, and make ethical research decisions.…

  14. Advanced instrumentation for aircraft icing research

    NASA Technical Reports Server (NTRS)

    Bachalo, W.; Smith, J.; Rudoff, R.

    1990-01-01

    A compact and rugged probe based on the phase Doppler method was evaluated as a means for characterizing icing clouds using airborne platforms and for advancing aircraft icing research in large scale wind tunnels. The Phase Doppler Particle Analyzer (PDPA) upon which the new probe was based is now widely recognized as an accurate method for the complete characterization of sprays. The prototype fiber optic-based probe was evaluated in simulated aircraft icing clouds and found to have the qualities essential to providing information that will advance aircraft icing research. Measurement comparisons of the size and velocity distributions made with the standard PDPA and the fiber optic probe were in excellent agreement as were the measurements of number density and liquid water content. Preliminary testing in the NASA Lewis Icing Research Tunnel (IRT) produced reasonable results but revealed some problems with vibration and signal quality at high speeds. The cause of these problems were identified and design changes were proposed to eliminate the shortcomings of the probe.

  15. Advanced methods of structural and trajectory analysis for transport aircraft

    NASA Technical Reports Server (NTRS)

    Ardema, Mark D.

    1995-01-01

    This report summarizes the efforts in two areas: (1) development of advanced methods of structural weight estimation, and (2) development of advanced methods of trajectory optimization. The majority of the effort was spent in the structural weight area. A draft of 'Analytical Fuselage and Wing Weight Estimation of Transport Aircraft', resulting from this research, is included as an appendix.

  16. The Truth, the Whole Truth, and Nothing but the Ground-Truth: Methods to Advance Environmental Justice and Researcher-Community Partnerships

    ERIC Educational Resources Information Center

    Sadd, James; Morello-Frosch, Rachel; Pastor, Manuel; Matsuoka, Martha; Prichard, Michele; Carter, Vanessa

    2014-01-01

    Environmental justice advocates often argue that environmental hazards and their health effects vary by neighborhood, income, and race. To assess these patterns and advance preventive policy, their colleagues in the research world often use complex and methodologically sophisticated statistical and geospatial techniques. One way to bridge the gap…

  17. Research on Advanced Thin Film Batteries

    SciTech Connect

    Goldner, Ronald B.

    2003-11-24

    During the past 7 years, the Tufts group has been carrying out research on advanced thin film batteries composed of a thin film LiCo02 cathode (positive electrode), a thin film LiPON (lithium phosphorous oxynitride) solid electrolyte, and a thin film graphitic carbon anode (negative electrode), under grant DE FG02-95ER14578. Prior to 1997, the research had been using an rfsputter deposition process for LiCoOi and LiPON and an electron beam evaporation or a controlled anode arc evaporation method for depositing the carbon layer. The pre-1997 work led to the deposition of a single layer cell that was successfully cycled for more than 400 times [1,2] and the research also led to the deposition of a monolithic double-cell 7 volt battery that was cycled for more than 15 times [3]. Since 1997, the research has been concerned primarily with developing a research-worthy and, possibly, a production-worthy, thin film deposition process, termed IBAD (ion beam assisted deposition) for depositing each ofthe electrodes and the electrolyte of a completely inorganic solid thin film battery. The main focus has been on depositing three materials - graphitic carbon as the negative electrode (anode), lithium cobalt oxide (nominally LiCoCb) as the positive electrode (cathode), and lithium phosphorus oxynitride (LiPON) as the electrolyte. Since 1998, carbon, LiCoOa, and LiPON films have been deposited using the IBAD process with the following results.

  18. Advancing Research on Undergraduate Science Learning

    ERIC Educational Resources Information Center

    Singer, Susan Rundell

    2013-01-01

    This special issue of "Journal of Research in Science Teaching" reflects conclusions and recommendations in the "Discipline-Based Education Research" (DBER) report and makes a substantial contribution to advancing the field. Research on undergraduate science learning is currently a loose affiliation of related fields. The…

  19. Advances in Education Research. Volume 2, 1997.

    ERIC Educational Resources Information Center

    Advances in Education Research, 1997

    1997-01-01

    "Advances in Education Research" reprints previously published journal articles reporting on research supported in whole or in part by the Office of Educational Research and Improvement (OERI). The articles are selected from peer-reviewed/referred journals; the journals used are described briefy at the end of the volume. The articles in this…

  20. Therapists and researchers: Advancing collaboration

    PubMed Central

    GARLAND, ANN F.; BROOKMAN-FRAZEE, LAUREN

    2016-01-01

    Collaborative partnerships between community-based clinicians and academic researchers have the potential to improve the relevance, utility, and feasibility of research, as well as the effectiveness of practice. Collaborative partnership research from a variety of fields can inform the development and maintenance of effective partnerships. In this paper we present a conceptual model of research-community practice partnership derived from literature across disciplines and then illustrate application of this model to one case example. The case example is a multi-year partnership between an interdisciplinary group of community-based psychotherapists and a team of mental health researchers. This partnership was initiated to support federally funded research on community-based out-patient mental health care for children with disruptive behavior problems, but it has evolved to drive and support new intervention studies with different clinical foci. Lessons learned from this partnership process will be shared and interpreted in the context of the presented research-practice partnership model. PMID:24224554

  1. Bringing Advanced Computational Techniques to Energy Research

    SciTech Connect

    Mitchell, Julie C

    2012-11-17

    Please find attached our final technical report for the BACTER Institute award. BACTER was created as a graduate and postdoctoral training program for the advancement of computational biology applied to questions of relevance to bioenergy research.

  2. Advancing Educational Policy by Advancing Research on Instruction

    ERIC Educational Resources Information Center

    Raudenbush, Stephen W.

    2008-01-01

    Understanding the impact of "instructional regimes" on student learning is central to advancing educational policy. Research on instructional regimes has parallels with clinical trials in medicine yet poses unique challenges because of the social nature of instruction: A child's potential outcome under a given regime depends on peers and teachers,…

  3. Advances in developmental prosopagnosia research.

    PubMed

    Susilo, Tirta; Duchaine, Bradley

    2013-06-01

    Developmental prosopagnosia (DP) refers to face recognition deficits in the absence of brain damage. DP affects ∼2% of the population, and it often runs in families. DP studies have made considerable progress in identifying the cognitive and neural characteristics of the disorder. A key challenge is to develop a valid taxonomy of DP that will facilitate many aspects of research.

  4. ADVANCED GAS TURBINE SYSTEMS RESEARCH

    SciTech Connect

    Unknown

    1999-10-01

    The activities of the AGTSR Program during this reporting period are described in this quarterly report. The report text is divided into discussions on Membership, Administration, Technology Transfer (Workshop/Education) and Research. Items worthy of note are highlighted below with additional detail following in the text of the report.

  5. Advancements in Cotton Harvesting Research

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Cotton harvesting research within USDA ARS is focused on improving harvest productivity, cotton quality, and producer profitability. In recent years, our work has encompassed efforts to improve both spindle picker and brush-roll stripper harvesting systems. Specifically, work with cotton pickers i...

  6. Research Advances: Onions Battle Osteoporosis

    ERIC Educational Resources Information Center

    King, Angela G.

    2005-01-01

    Researchers at the University of Bern in Switzerland have identified a compound in the popular vegetable that appears to decrease bone loss in laboratory studies using rat bone cells. It is suggested that eating onions might help prevent bone loss and osteoporosis, a disease, which predominantly affects older women.

  7. Advances in Activity Cliff Research.

    PubMed

    Dimova, Dilyana; Bajorath, Jürgen

    2016-05-01

    Activity cliffs, i.e. similar compounds with large potency differences, are of interest from a chemical and informatics viewpoint; as a source of structure-activity relationship information, for compound optimization, and activity prediction. Herein, recent highlights of activity cliff research are discussed including studies that have further extended our understanding of activity cliffs, yielded unprecedented insights, or paved the way for practical applications.

  8. Advances in Activity Cliff Research.

    PubMed

    Dimova, Dilyana; Bajorath, Jürgen

    2016-05-01

    Activity cliffs, i.e. similar compounds with large potency differences, are of interest from a chemical and informatics viewpoint; as a source of structure-activity relationship information, for compound optimization, and activity prediction. Herein, recent highlights of activity cliff research are discussed including studies that have further extended our understanding of activity cliffs, yielded unprecedented insights, or paved the way for practical applications. PMID:27492084

  9. Advancing Manufacturing Research Through Competitions

    SciTech Connect

    Balakirsky, Stephen; Madhavan, Raj

    2009-01-01

    Competitions provide a technique for building interest and collaboration in targeted research areas. This paper will present a new competition that aims to increase collaboration amongst Universities, automation end-users, and automation manufacturers through a virtual competition. The virtual nature of the competition allows for reduced infrastructure requirements while maintaining realism in both the robotic equipment deployed and the scenarios. Details of the virtual environment as well as the competitions objectives, rules, and scoring metrics will be presented.

  10. Research methods of inquiry.

    PubMed

    Rodgers, Joel; Foushee, Russell; Terndrup, Thomas E; Gaddis, Gary M

    2006-11-01

    Incidents of significant consequence that create surge may require special research methods to provide reliable, generalizable results. This report was constructed through a process of literature review, expert panel discussion at the journal's consensus conference, and iterative development. Traditional clinical research methods that are well accepted in medicine are exceptionally difficult to use for surge incidents because the incidents are very difficult to reliably predict, the consequences vary widely, human behaviors are heterogeneous in response to incidents, and temporal conditions prioritize limited resources to response, rather than data collection. Current literature on surge research methods has found some degree of reliability and generalizability in case-control, postincident survey methods, and ethnographical designs. Novel methods that show promise for studying surge include carefully validated simulation experiments and survey methods that produce validated results from representative populations. Methodologists and research scientists should consider quasi-experimental designs and case-control studies in areas with recurrent high-consequence incidents (e.g., earthquakes and hurricanes). Specialists that need to be well represented in areas of research include emergency physicians and critical care physicians, simulation engineers, cost economists, sociobehavioral methodologists, and others.

  11. Linguistic Alternatives to Quantitative Research Strategies. Part One: How Linguistic Mechanisms Advance Research Outcomes

    ERIC Educational Resources Information Center

    Yeager, Joseph; Sommer, Linda

    2007-01-01

    Combining psycholinguistic technologies and systems analysis created advances in motivational profiling and numerous new behavioral engineering applications. These advances leapfrog many mainstream statistical research methods, producing superior research results via cause-effect language mechanisms. Entire industries explore motives ranging from…

  12. Research priorities for advanced fibrous composites

    NASA Technical Reports Server (NTRS)

    Baumann, K. J.; Swedlow, J. L.

    1981-01-01

    Priorities for research in advanced laminated fibrous composite materials are presented. Supporting evidence is presented in two bodies, including a general literature survey and a survey of aerospace composite hardware and service experience. Both surveys were undertaken during 1977-1979. Specific results and conclusions indicate that a significant portion of contemporary published research diverges from recommended priorites.

  13. Advances in personality theory and research.

    PubMed Central

    Stelmack, R M

    1991-01-01

    This paper briefly describes important advances in personality research that have been achieved during the past 20 years in the development of a fundamental personality typology and in the determination of the heritability of personality traits. Research conducted at the University of Ottawa that has contributed to the exploration of the biological bases of the extraversion trait is summarized. PMID:1958646

  14. Advances in plant gene silencing methods.

    PubMed

    Pandey, Prachi; Senthil-Kumar, Muthappa; Mysore, Kirankumar S

    2015-01-01

    Understanding molecular mechanisms of transcriptional and posttranscriptional gene silencing pathways in plants over the past decades has led to development of tools and methods for silencing a target gene in various plant species. In this review chapter, both the recent understanding of molecular basis of gene silencing pathways and advances in various widely used gene silencing methods are compiled. We also discuss the salient features of the different methods like RNA interference (RNAi) and virus-induced gene silencing (VIGS) and highlight their advantages and disadvantages. Gene silencing technology is constantly progressing as reflected by rapidly emerging new methods. A succinct discussion on the recently developed methods like microRNA-mediated virus-induced gene silencing (MIR-VIGS) and microRNA-induced gene silencing (MIGS) is also provided. One major bottleneck in gene silencing approaches has been the associated off-target silencing. The other hurdle has been the lack of a universal approach that can be applied to all plants. For example, we face hurdles like incompatibility of VIGS vectors with the host and inability to use MIGS for plant species which are not easily transformable. However, the overwhelming research in this direction reflects the scope for overcoming the short comings of gene silencing technology.

  15. Advances in agricultural research. [Review

    SciTech Connect

    Leepson, M.

    1981-05-22

    Several factors could have disastrous consequences for the world's food supply, namely: shrinking agricultural acreage; increasing population; decreasing productivity gains in most crops; heavy dependence on petroleum-based pesticides and fertilizers; and genetic vulnerability. Many feel that solutions to these potentially grave problems lie in expanding agricultural research, with particular focus on age-old plant-breeding techniques. The newest plant-breeding technology, genetic engineering (also called recombinant DNA technology), could some day allow biologists to design actually new genetic material rather than just manipulate genetic material already present in crops. Most scientists foresee imminent breakthroughs with recombinant DNA technology and plant breeding, but warn the practial applications may be decades away - perhaps 20 to 50 years. Many of the larger chemical companies are working in the following areas of agriculture R and D: nitrogen fixation; plant growth regulants; photosynthesis; recombinant DNA; plant genetics; and soybean hybrids. New progress in hydroponic technology is reported briefly. Germ plasm collection and storage is being pursued in the US, Soviet Union, and Mexico; US activities are summarized. In addition to the chemical-company efforts in R and D, there have been many acquisitions of seed companies by some of the nation's largest corporations in the last decade; a significant difference of opinion exists as to what this growing corporate involvement portends for agriculture. 49 references, 1 figure, 3 tables.

  16. Advanced methods for processing ceramics

    SciTech Connect

    Carter, W.B.

    1997-04-01

    Combustion chemical vapor deposition (combustion CVD) is being developed for the deposition of high temperature oxide coatings. The process is being evaluated as an alternative to more capital intensive conventional coating processes. The thrusts during this reporting period were the development of the combustion CVD process for depositing lanthanum monazite, the determination of the influence of aerosol size on coating morphology, the incorporation of combustion CVD coatings into thermal barrier coatings (TBCs) and related oxidation research, and continued work on the deposition of zirconia-yttria coatings.

  17. ADVANCED GAS TURBINE SYSTEMS RESEARCH PROGRAM

    SciTech Connect

    Lawrence P. Golan

    2002-07-01

    The quarterly activities of the Advanced Gas Turbine Systems Research (AGTSR) program are described in this quarterly report. As this program administers research, we have included all program activity herein within the past quarter as dated. More specific research progress reports are provided weekly at the request of the AGTSR COR and are being sent to NETL As for the administration of this program, items worthy of note are presented in extended bullet format following the appropriate heading.

  18. ADVANCED GAS TURBINE SYSTEMS RESEARCH PROGRAM

    SciTech Connect

    Lawrence P. Golan

    2001-07-01

    The quarterly activities of the Advanced Gas Turbine Systems Research (AGTSR) program are described in this quarterly report. As this program administers research, we have included all program activity herein within the past quarter as dated. More specific research progress reports are provided weekly at the request of the AGTSR COR and are being sent to NETL. As for the administration of this program, items worthy of note are presented in extended bullet format following the appropriate heading.

  19. Advanced electromagnetic methods for aerospace vehicles

    NASA Astrophysics Data System (ADS)

    Balanis, Constantine A.; Sun, Weimin; El-Sharawy, El-Budawy; Aberle, James T.; Birtcher, Craig R.; Peng, Jian; Tirkas, Panayiotis A.; Kokotoff, David; Zavosh, Frank

    1993-06-01

    The Advanced Helicopter Electromagnetics (AHE) Industrial Associates Program has continuously progressed with its research effort focused on subjects identified and recommended by the Advisory Task Force of the program. The research activities in this reporting period have been steered toward practical helicopter electromagnetic problems, such as HF antenna problems and antenna efficiencies, recommended by the AHE members at the annual conference held at Arizona State University on 28-29 Oct. 1992 and the last biannual meeting held at the Boeing Helicopter on 19-20 May 1993. The main topics addressed include the following: Composite Materials and Antenna Technology. The research work on each topic is closely tied with the AHE Consortium members' interests. Significant progress in each subject is reported. Special attention in the area of Composite Materials has been given to the following: modeling of material discontinuity and their effects on towel-bar antenna patterns; guidelines for composite material modeling by using the Green's function approach in the NEC code; measurements of towel-bar antennas grounded with a partially material-coated plate; development of 3-D volume mesh generator for modeling thick and volumetric dielectrics by using FD-TD method; FDTD modeling of horn antennas with composite E-plane walls; and antenna efficiency analysis for a horn antenna loaded with composite dielectric materials.

  20. Advanced electromagnetic methods for aerospace vehicles

    NASA Technical Reports Server (NTRS)

    Balanis, Constantine A.; Sun, Weimin; El-Sharawy, El-Budawy; Aberle, James T.; Birtcher, Craig R.; Peng, Jian; Tirkas, Panayiotis A.; Kokotoff, David; Zavosh, Frank

    1993-01-01

    The Advanced Helicopter Electromagnetics (AHE) Industrial Associates Program has continuously progressed with its research effort focused on subjects identified and recommended by the Advisory Task Force of the program. The research activities in this reporting period have been steered toward practical helicopter electromagnetic problems, such as HF antenna problems and antenna efficiencies, recommended by the AHE members at the annual conference held at Arizona State University on 28-29 Oct. 1992 and the last biannual meeting held at the Boeing Helicopter on 19-20 May 1993. The main topics addressed include the following: Composite Materials and Antenna Technology. The research work on each topic is closely tied with the AHE Consortium members' interests. Significant progress in each subject is reported. Special attention in the area of Composite Materials has been given to the following: modeling of material discontinuity and their effects on towel-bar antenna patterns; guidelines for composite material modeling by using the Green's function approach in the NEC code; measurements of towel-bar antennas grounded with a partially material-coated plate; development of 3-D volume mesh generator for modeling thick and volumetric dielectrics by using FD-TD method; FDTD modeling of horn antennas with composite E-plane walls; and antenna efficiency analysis for a horn antenna loaded with composite dielectric materials.

  1. Advanced electromagnetic methods for aerospace vehicles

    NASA Technical Reports Server (NTRS)

    Balanis, Constantine A.; Sun, Weimin; El-Sharawy, El-Budawy; Aberle, James T.; Birtcher, Craig R.; Peng, Jian; Tirkas, Panayiotis A.; Andrew, William V.; Kokotoff, David; Zavosh, Frank

    1993-01-01

    The Advanced Helicopter Electromagnetics (AHE) Industrial Associates Program has fruitfully completed its fourth year. Under the support of the AHE members and the joint effort of the research team, new and significant progress has been achieved in the year. Following the recommendations by the Advisory Task Force, the research effort is placed on more practical helicopter electromagnetic problems, such as HF antennas, composite materials, and antenna efficiencies. In this annual report, the main topics to be addressed include composite materials and antenna technology. The research work on each topic has been driven by the AHE consortium members' interests and needs. The remarkable achievements and progresses in each subject is reported respectively in individual sections of the report. The work in the area of composite materials includes: modeling of low conductivity composite materials by using Green's function approach; guidelines for composite material modeling by using the Green's function approach in the NEC code; development of 3-D volume mesh generator for modeling thick and volumetric dielectrics by using FD-TD method; modeling antenna elements mounted on a composite Comanche tail stabilizer; and antenna pattern control and efficiency estimate for a horn antenna loaded with composite dielectric materials.

  2. Research priorities and history of advanced composite compression testing

    NASA Technical Reports Server (NTRS)

    Baumann, K. J.

    1981-01-01

    Priorities for standard compression testing research in advanced laminated fibrous composite materials are presented along with a state of the art survey (completed in 1979) including history and commentary on industrial test methods. Historically apparent research priorities and consequent (lack of) progress are supporting evidence for newly derived priorities.

  3. Advanced Fine Particulate Characterization Methods

    SciTech Connect

    Steven Benson; Lingbu Kong; Alexander Azenkeng; Jason Laumb; Robert Jensen; Edwin Olson; Jill MacKenzie; A.M. Rokanuzzaman

    2007-01-31

    The characterization and control of emissions from combustion sources are of significant importance in improving local and regional air quality. Such emissions include fine particulate matter, organic carbon compounds, and NO{sub x} and SO{sub 2} gases, along with mercury and other toxic metals. This project involved four activities including Further Development of Analytical Techniques for PM{sub 10} and PM{sub 2.5} Characterization and Source Apportionment and Management, Organic Carbonaceous Particulate and Metal Speciation for Source Apportionment Studies, Quantum Modeling, and High-Potassium Carbon Production with Biomass-Coal Blending. The key accomplishments included the development of improved automated methods to characterize the inorganic and organic components particulate matter. The methods involved the use of scanning electron microscopy and x-ray microanalysis for the inorganic fraction and a combination of extractive methods combined with near-edge x-ray absorption fine structure to characterize the organic fraction. These methods have direction application for source apportionment studies of PM because they provide detailed inorganic analysis along with total organic and elemental carbon (OC/EC) quantification. Quantum modeling using density functional theory (DFT) calculations was used to further elucidate a recently developed mechanistic model for mercury speciation in coal combustion systems and interactions on activated carbon. Reaction energies, enthalpies, free energies and binding energies of Hg species to the prototype molecules were derived from the data obtained in these calculations. Bimolecular rate constants for the various elementary steps in the mechanism have been estimated using the hard-sphere collision theory approximation, and the results seem to indicate that extremely fast kinetics could be involved in these surface reactions. Activated carbon was produced from a blend of lignite coal from the Center Mine in North Dakota and

  4. Ergonomics research methods

    NASA Technical Reports Server (NTRS)

    Uspenskiy, S. I.; Yermakova, S. V.; Chaynova, L. D.; Mitkin, A. A.; Gushcheva, T. M.; Strelkov, Y. K.; Tsvetkova, N. F.

    1973-01-01

    Various factors used in ergonomic research are given. They are: (1) anthrometric measurement, (2) polyeffector method of assessing the functional state of man, (3) galvanic skin reaction, (4) pneumography, (5) electromyography, (6) electrooculography, and (7) tachestoscopy. A brief summary is given of each factor and includes instrumentation and results.

  5. Recent advances in lattice Boltzmann methods

    SciTech Connect

    Chen, S.; Doolen, G.D.; He, X.; Nie, X.; Zhang, R.

    1998-12-31

    In this paper, the authors briefly present the basic principles of lattice Boltzmann method and summarize recent advances of the method, including the application of the lattice Boltzmann method for fluid flows in MEMS and simulation of the multiphase mixing and turbulence.

  6. Advanced Sciences and Technology Research for Astrodynamics

    NASA Astrophysics Data System (ADS)

    Jah, M.

    The Advanced Sciences and Technology Research Institute for Astrodynamics (ASTRIA) has been created as a research endeavor that focuses all astrodynamics R&D within the Air Force Research Laboratory (AFRL). ASTRIA is mainly a consortium of academic partners brought together to bear on the nation's challenges as related to astrodynamics sciences and technologies. An overview of ASTRIA is presented as well as examples of several research efforts that are relevant to data/track association, UCT/cross-tagging mitigation, and attitude recovery from light curve data.

  7. ADVANCED GAS TURBINE SYSTEMS RESEARCH PROGRAM

    SciTech Connect

    Lawrence P. Golan

    2003-05-01

    The activities of the Advanced Gas Turbine Systems Research (AGTSR) program for the reporting period October 1, 2002 to December 31, 2002 are described in this quarterly report. No new membership, workshops, research projects, internships, faculty fellowships or special studies were initiated during this reporting period. Contract completion is set for June 30, 2003. During the report period, six research progress reports were received (3 final reports and 3 semi-annual reports). The University of Central Florida contract SR080 was terminated during this period, as UCF was unable to secure research facilities. AGTSR now projects that it will under spend DOE obligated funds by approximately 340-350K$.

  8. Proposed research on advanced accelerator concepts

    SciTech Connect

    Davidson, R.C.; Wurtele, J.S.

    1991-09-01

    This report summarizes technical progress and accomplishments during the proposed three-year research on advanced accelerator concepts supported by the Department of Energy under Contract No. DE-FG02-88ER40465. A vigorous theoretical program has been pursued in critical problem areas related to advanced accelerator concepts and the basic equilibrium, stability, and radiation properties of intense charged particle beams. Broadly speaking, our research has made significant contributions in the following three major areas: Investigations of physics issues related to particle acceleration including two-beam accelerators and cyclotron resonance laser (CRL) accelerators; Investigations of RF sources including the free- electron lasers, cyclotron resonance masers, and relativistic magnetrons; Studies of coherent structures in electron plasmas and beams ranging from a low-density, nonrelativistic, pure electron plasma column to high-density, relativistic, non-neutral electron flow in a high-voltage diode. The remainder of this report presents theoretical and computational advances in these areas.

  9. Clinical Research Informatics: Recent Advances and Future Directions

    PubMed Central

    2015-01-01

    Summary Objectives To summarize significant developments in Clinical Research Informatics (CRI) over the past two years and discuss future directions. Methods Survey of advances, open problems and opportunities in this field based on exploration of current literature. Results Recent advances are structured according to three use cases of clinical research: Protocol feasibility, patient identification/recruitment and clinical trial execution. Discussion CRI is an evolving, dynamic field of research. Global collaboration, open metadata, content standards with semantics and computable eligibility criteria are key success factors for future developments in CRI. PMID:26293865

  10. Coordinating Space Nuclear Research Advancement and Education

    SciTech Connect

    John D. Bess; Jonathon A. Webb; Brian J. Gross; Aaron E. Craft

    2009-11-01

    The advancement of space exploration using nuclear science and technology has been a goal sought by many individuals over the years. The quest to enable space nuclear applications has experienced many challenges such as funding restrictions; lack of political, corporate, or public support; and limitations in educational opportunities. The Center for Space Nuclear Research (CSNR) was established at the Idaho National Laboratory (INL) with the mission to address the numerous challenges and opportunities relevant to the promotion of space nuclear research and education.1 The CSNR is operated by the Universities Space Research Association and its activities are overseen by a Science Council comprised of various representatives from academic and professional entities with space nuclear experience. Program participants in the CSNR include academic researchers and students, government representatives, and representatives from industrial and corporate entities. Space nuclear educational opportunities have traditionally been limited to various sponsored research projects through government agencies or industrial partners, and dedicated research centers. Centralized research opportunities are vital to the growth and development of space nuclear advancement. Coordinated and focused research plays a key role in developing the future leaders in the space nuclear field. The CSNR strives to synchronize research efforts and provide means to train and educate students with skills to help them excel as leaders.

  11. Research Opportunities in Advanced Aerospace Concepts

    NASA Technical Reports Server (NTRS)

    Jones, Gregory S.; Bangert, Linda S.; Garber, Donald P.; Huebner, Lawrence D.; McKinley, Robert E.; Sutton, Kenneth; Swanson, Roy C., Jr.; Weinstein, Leonard

    2000-01-01

    This report is a review of a team effort that focuses on advanced aerospace concepts of the 21st Century. The paper emphasis advanced technologies, rather than cataloging every unusual aircraft that has ever been attempted. To dispel the myth that "aerodynamics is a mature science" an extensive list of "What we cannot do, or do not know" was enumerated. A zeit geist, a feeling for the spirit of the times, was developed, based on existing research goals. Technological drivers and the constraints that might influence these technological developments in a future society were also examined. The present status of aeronautics, space exploration, and non-aerospace applications, both military and commercial, including enabling technologies are discussed. A discussion of non-technological issues affecting advanced concepts research is presented. The benefit of using the study of advanced vehicles as a tool to uncover new directions for technology development is often necessary. An appendix is provided containing examples of advanced vehicle configurations currently of interest.

  12. Why Video? How Technology Advances Method

    ERIC Educational Resources Information Center

    Downing, Martin J., Jr.

    2008-01-01

    This paper reports on the use of video to enhance qualitative research. Advances in technology have improved our ability to capture lived experiences through visual means. I reflect on my previous work with individuals living with HIV/AIDS, the results of which are described in another paper, to evaluate the effectiveness of video as a medium that…

  13. Land reclamation: Advances in research technology

    SciTech Connect

    Younos, T.; Diplas, P.; Mostaghimi, S.

    1992-01-01

    Land reclamation encompasses remediation of industrial wasteland, improvement of infertile land for agricultural production, preservation of wetlands, and restoration of disturbed areas. Land reclamation is an integral part of sustainable development which aims to reconcile economic productivity with environmental preservation. During the 1980s, significant progress was achieved in the application of advanced technologies to sustainable development projects. The goal of this international symposium was to serve as a forum to review current research and state-of-the-art technology dealing with various aspects of land reclamation, and provide an opportunity for professional interaction and exchange of information in a multi-disciplinary setting. The scope of the symposium was as broad as the topic itself. The keynote address by Professor John Cairns focused on a systems approach in land restoration projects and challenges facing scientists in global biotic impoverishment. Other topics discussed in ten mechanical sessions included development and applications of computer models, geographic information systems, remote sensing technology, salinity problems, surface and ground water monitoring, reclamation of mine areas, soil amendment methods and impacts, wetland restoration techniques, and land use planning for resource protection.

  14. Symposium on ASME codes and recent advances in PVP and valve technology including a survey of operations research methods in engineering

    SciTech Connect

    Fong, J.T.; Hollinger, G.L.; Gowda, B.; Ezekoye, L.I.; Levary, R.R.

    1986-01-01

    This book presents the papers given at a symposium on the design and engineering of reactor pressure vessels, pipes and valves. Topics considered at the symposium included computer-aided fatigue design methods for weldments, the propagation of defects under PWR loading conditions, the fatigue of welded joints in elevated-temperature nuclear components, the design of a bolted flange subjected to severe nuclear system thermal transients, and operations research methods.

  15. Advanced electromagnetic methods for aerospace vehicles

    NASA Technical Reports Server (NTRS)

    Balanis, Constantine A.; Sun, Weimin; El-Sharawy, El-Budawy; Aberle, James T.; Birtcher, Craig R.; Peng, Jian; Tirkas, Panayiotis A.

    1992-01-01

    The Advanced Helicopter Electromagnetics (AHE) Industrial Associates Program continues its research on variety of main topics identified and recommended by the Advisory Task Force of the program. The research activities center on issues that advance technology related to helicopter electromagnetics. While most of the topics are a continuation of previous works, special effort has been focused on some of the areas due to recommendations from the last annual conference. The main topics addressed in this report are: composite materials, and antenna technology. The area of composite materials continues getting special attention in this period. The research has focused on: (1) measurements of the electrical properties of low-conductivity materials; (2) modeling of material discontinuity and their effects on the scattering patterns; (3) preliminary analysis on interaction of electromagnetic fields with multi-layered graphite fiberglass plates; and (4) finite difference time domain (FDTD) modeling of fields penetration through composite panels of a helicopter.

  16. Advanced analysis methods in particle physics

    SciTech Connect

    Bhat, Pushpalatha C.; /Fermilab

    2010-10-01

    Each generation of high energy physics experiments is grander in scale than the previous - more powerful, more complex and more demanding in terms of data handling and analysis. The spectacular performance of the Tevatron and the beginning of operations of the Large Hadron Collider, have placed us at the threshold of a new era in particle physics. The discovery of the Higgs boson or another agent of electroweak symmetry breaking and evidence of new physics may be just around the corner. The greatest challenge in these pursuits is to extract the extremely rare signals, if any, from huge backgrounds arising from known physics processes. The use of advanced analysis techniques is crucial in achieving this goal. In this review, I discuss the concepts of optimal analysis, some important advanced analysis methods and a few examples. The judicious use of these advanced methods should enable new discoveries and produce results with better precision, robustness and clarity.

  17. Advanced energy projects FY 1997 research summaries

    SciTech Connect

    1997-09-01

    The mission of the Advanced Energy Projects (AEP) program is to explore the scientific feasibility of novel energy-related concepts that are high risk, in terms of scientific feasibility, yet have a realistic potential for a high technological payoff. The concepts supported by the AEP are typically at an early stage of scientific development. They often arise from advances in basic research and are premature for consideration by applied research or technology development programs. Some are based on discoveries of new scientific phenomena or involve exploratory ideas that span multiple scientific and technical disciplines which do not fit into an existing DOE program area. In all cases, the objective is to support evaluation of the scientific or technical feasibility of the novel concepts involved. Following AEP support, it is expected that each concept will be sufficiently developed to attract further funding from other sources to realize its full potential. Projects that involve evolutionary research or technology development and demonstration are not supported by AEP. Furthermore, research projects more appropriate for another existing DOE research program are not encouraged. There were 65 projects in the AEP research portfolio during Fiscal Year 1997. Eigheen projects were initiated during that fiscal year. This document consists of short summaries of projects active in FY 1997. Further information of a specific project may be obtained by contacting the principal investigator.

  18. ISAAC - A Testbed for Advanced Composites Research

    NASA Technical Reports Server (NTRS)

    Wu, K. Chauncey; Stewart, Brian K.; Martin, Robert A.

    2014-01-01

    The NASA Langley Research Center is acquiring a state-of-art composites fabrication environment to support the Center's research and technology development mission. This overall system described in this paper is named ISAAC, or Integrated Structural Assembly of Advanced Composites. ISAAC's initial operational capability is a commercial robotic automated fiber placement system from Electroimpact, Inc. that consists of a multi-degree of freedom commercial robot platform, a tool changer mechanism, and a specialized automated fiber placement end effector. Examples are presented of how development of advanced composite materials, structures, fabrication processes and technology are enabled by utilizing the fiber placement end effector directly or with appropriate modifications. Alternatively, end effectors with different capabilities may either be bought or developed with NASA's partners in industry and academia.

  19. Systems Engineering Building Advances Power Grid Research

    SciTech Connect

    Virden, Jud; Huang, Henry; Skare, Paul; Dagle, Jeff; Imhoff, Carl; Stoustrup, Jakob; Melton, Ron; Stiles, Dennis; Pratt, Rob

    2015-08-19

    Researchers and industry are now better equipped to tackle the nation’s most pressing energy challenges through PNNL’s new Systems Engineering Building – including challenges in grid modernization, buildings efficiency and renewable energy integration. This lab links real-time grid data, software platforms, specialized laboratories and advanced computing resources for the design and demonstration of new tools to modernize the grid and increase buildings energy efficiency.

  20. [Research Advances in Cyprinid Herpesvirus 3].

    PubMed

    Zheng, Shucheng; Wang, Qing; Li, Yingying; Zeng, Weiwei; Wang, Yingying; Liu, Chun; Liang, Hongru; Shi, Cunbin

    2016-01-01

    Cyprinid herpesvirus 3 (CyHV-3) is the causative agent of an extremely contagious and aggressive disease afflicting common corp Cyprinus carpio L. termed koi herpesvirus disease (KHVD). Since it was first reported in 1997, the virus has spread worldwide rapidly, leading to enormous financial losses in industries based on common carp and koi carp. This review summarizes recent advances in CyHV-3 research on the etiology, epidemiology, pathogenesis, diagnosis, prevention, and control of KHVD. PMID:27295892

  1. Medical technology advances from space research

    NASA Technical Reports Server (NTRS)

    Pool, S. L.

    1972-01-01

    Details of medical research and development programs, particularly an integrated medical laboratory, as derived from space technology are given. The program covers digital biotelemetry systems, automatic visual field mapping equipment, sponge electrode caps for clinical electroencephalograms, and advanced respiratory analysis equipment. The possibility of using the medical laboratory in ground based remote areas and regional health care facilities, as well as long duration space missions is discussed.

  2. Defining Neighborhood Boundaries for Social Measurement: Advancing Social Work Research

    ERIC Educational Resources Information Center

    Foster, Kirk A.; Hipp, J. Aaron

    2011-01-01

    Much of the current neighborhood-based research uses variables aggregated on administrative boundaries such as zip codes, census tracts, and block groups. However, other methods using current technological advances in geographic sciences may broaden our ability to explore the spatial concentration of neighborhood factors affecting individuals and…

  3. Clinical Application and Research Advances of CT Myocardial Perfusion Imaging.

    PubMed

    2016-06-10

    Computed tomography (CT)-based myocardial perfusion imaging (CTP)has been widely recognized as a one-station solution for the imaging of myocardial ischemia-related diseases. This article reviews the clinical scanning protocols,analytical methods,and research advances of CTP in recent years and briefly discusses its limitations and future development. PMID:27469926

  4. Research Institute for Advanced Computer Science

    NASA Technical Reports Server (NTRS)

    Gross, Anthony R. (Technical Monitor); Leiner, Barry M.

    2000-01-01

    The Research Institute for Advanced Computer Science (RIACS) carries out basic research and technology development in computer science, in support of the National Aeronautics and Space Administration's missions. RIACS is located at the NASA Ames Research Center. It currently operates under a multiple year grant/cooperative agreement that began on October 1, 1997 and is up for renewal in the year 2002. Ames has been designated NASA's Center of Excellence in Information Technology. In this capacity, Ames is charged with the responsibility to build an Information Technology Research Program that is preeminent within NASA. RIACS serves as a bridge between NASA Ames and the academic community, and RIACS scientists and visitors work in close collaboration with NASA scientists. RIACS has the additional goal of broadening the base of researchers in these areas of importance to the nation's space and aeronautics enterprises. RIACS research focuses on the three cornerstones of information technology research necessary to meet the future challenges of NASA missions: (1) Automated Reasoning for Autonomous Systems. Techniques are being developed enabling spacecraft that will be self-guiding and self-correcting to the extent that they will require little or no human intervention. Such craft will be equipped to independently solve problems as they arise, and fulfill their missions with minimum direction from Earth; (2) Human-Centered Computing. Many NASA missions require synergy between humans and computers, with sophisticated computational aids amplifying human cognitive and perceptual abilities; (3) High Performance Computing and Networking. Advances in the performance of computing and networking continue to have major impact on a variety of NASA endeavors, ranging from modeling and simulation to data analysis of large datasets to collaborative engineering, planning and execution. In addition, RIACS collaborates with NASA scientists to apply information technology research to a

  5. UZIG USGS research: Advances through interdisciplinary interaction

    USGS Publications Warehouse

    Nimmo, J.R.; Andraski, B.J.; Rafael, M.-C.

    2009-01-01

    Because vadose zone research relates to diverse disciplines, applications, and modes of research, collaboration across traditional operational and topical divisions is especially likely to yield major advances in understanding. The Unsaturated Zone Interest Group (UZIG) is an informal organization sponsored by the USGS to encourage and support interdisciplinary collaboration in vadose or unsaturated zone hydrologic research across organizational boundaries. It includes both USGS and non-USGS scientists. Formed in 1987, the UZIG operates to promote communication, especially through periodic meetings with presentations, discussions, and fi eld trips. The 10th meeting of the UZIG at Los Alamos, NM, in August 2007 was jointly sponsored by the USGS and Los Alamos National Laboratory. Presentations at this meeting served as the initial basis for selecting papers for this special section of Vadose Zone Journal, the purpose of which is to present noteworthy cuting-edge unsaturated zone research promoted by, facilitated by, or presented in connection with the UZIG. ?? Soil Science Society of America.

  6. ADVANCED GAS TURBINE SYSTEMS RESEARCH PROGRAM

    SciTech Connect

    Lawrence P. Golan

    2003-05-01

    The quarterly activities of the Advanced Gas Turbine Systems Research (AGTSR) program are described in this quarterly report. As this program administers research, we have included all program activity herein within the past quarter as dated. More specific research progress reports are provided weekly at the request of the AGTSR COR and are being sent to NETL As for the administration of this program, items worthy of note are presented in extended bullet format following the appropriate heading. No new memberships, workshops, research projects, internships, faculty fellowships or special studies were initiated during this reporting period. Contract completion is set for June 30, 2003. During the report period, nine subcontractor reports were received (5 final reports and 4 semi-annual reports). The report technology distribution is as follows: 3--aero-heat transfer, 2--combustion and 4--materials. AGTSR continues to project that it will under spend DOE obligated funds by approximately $329K.

  7. Advancing the research agenda for diagnostic error reduction.

    PubMed

    Zwaan, Laura; Schiff, Gordon D; Singh, Hardeep

    2013-10-01

    Diagnostic errors remain an underemphasised and understudied area of patient safety research. We briefly summarise the methods that have been used to conduct research on epidemiology, contributing factors and interventions related to diagnostic error and outline directions for future research. Research methods that have studied epidemiology of diagnostic error provide some estimate on diagnostic error rates. However, there appears to be a large variability in the reported rates due to the heterogeneity of definitions and study methods used. Thus, future methods should focus on obtaining more precise estimates in different settings of care. This would lay the foundation for measuring error rates over time to evaluate improvements. Research methods have studied contributing factors for diagnostic error in both naturalistic and experimental settings. Both approaches have revealed important and complementary information. Newer conceptual models from outside healthcare are needed to advance the depth and rigour of analysis of systems and cognitive insights of causes of error. While the literature has suggested many potentially fruitful interventions for reducing diagnostic errors, most have not been systematically evaluated and/or widely implemented in practice. Research is needed to study promising intervention areas such as enhanced patient involvement in diagnosis, improving diagnosis through the use of electronic tools and identification and reduction of specific diagnostic process 'pitfalls' (eg, failure to conduct appropriate diagnostic evaluation of a breast lump after a 'normal' mammogram). The last decade of research on diagnostic error has made promising steps and laid a foundation for more rigorous methods to advance the field.

  8. JPL basic research review. [research and advanced development

    NASA Technical Reports Server (NTRS)

    1977-01-01

    Current status, projected goals, and results of 49 research and advanced development programs at the Jet Propulsion Laboratory are reported in abstract form. Areas of investigation include: aerodynamics and fluid mechanics, applied mathematics and computer sciences, environment protection, materials science, propulsion, electric and solar power, guidance and navigation, communication and information sciences, general physics, and chemistry.

  9. Advanced energy projects FY 1994 research summaries

    SciTech Connect

    Not Available

    1994-09-01

    The Division of Advanced Energy Projects (AEP) provides support to explore the feasibility of novel, energy-related concepts that evolve from advances in basic research. These concepts are typically at an early stage of scientific definition and, therefore, are premature for consideration by applied research or technology development programs. The AEP also supports high-risk, exploratory concepts that do not readily fit into a program area but could have several applications that may span scientific disciplines or technical areas. Projects supported by the Division arise from unsolicited ideas and concepts submitted by researchers. The portfolio of projects is dynamic and reflects the broad role of the Department in supporting research and development for improving the Nation`s energy outlook. FY 1994 projects include the following topical areas: novel materials for energy technology; renewable and biodegradable materials; exploring uses of new scientific discoveries; alternate pathways to energy efficiency; alternative energy sources; and innovative approaches to waste treatment and reduction. Summaries are given for 66 projects.

  10. Research Methods Tutorial

    NASA Technical Reports Server (NTRS)

    Aguilera, Frank J.

    2015-01-01

    A guiding principle for conducting research in technology, science, and engineering, leading to innovation is based on our use of research methodology (both qualitative and quantitative). A brief review of research methodology will be presented with an overview of NASA process in developing aeronautics technologies and other things to consider in research including what is innovation.

  11. Research Methods Tutorial

    NASA Technical Reports Server (NTRS)

    Aguilera, Frank J.

    2015-01-01

    A guiding principle for conducting research in technology, science, and engineering, leading to innovation is based on our use of research methodology (both qualitative and qualitative). A brief review of research methodology will be presented with an overview of NASA process in developing aeronautics technologies and other things to consider in research including what is innovation.

  12. [The advances of suppression in research of amblyopia].

    PubMed

    Liu, S; Liu, H

    2016-04-11

    Suppression that is the result of interocular competition is an important machanism of amblyopia. The imbalance of suppression may lead the consequence to amblyopia. In the early study, researchers had raised the theory of II. Quadratic Summation which had revealed the relationship of interocular interaction and suppression. In some basic researches, other studies had showed the most possible anatomic location of suppression. Recently, researchers found a new method to quantify the interocular suppression named the noise model. Further studies found a novel disinhibition therapy to treat amblyopia. We summarized the research advances in suppression and disinhibition treatment in amblyopia. (Chin J Ophthalmol, 2016, 52: 305-308). PMID:27094069

  13. Advanced Satellite Research Project: SCAR Research Database. Bibliographic analysis

    NASA Technical Reports Server (NTRS)

    Pelton, Joseph N.

    1991-01-01

    The literature search was provided to locate and analyze the most recent literature that was relevant to the research. This was done by cross-relating books, articles, monographs, and journals that relate to the following topics: (1) Experimental Systems - Advanced Communications Technology Satellite (ACTS), and (2) Integrated System Digital Network (ISDN) and Advance Communication Techniques (ISDN and satellites, ISDN standards, broadband ISDN, flame relay and switching, computer networks and satellites, satellite orbits and technology, satellite transmission quality, and network configuration). Bibliographic essay on literature citations and articles reviewed during the literature search task is provided.

  14. Research for Lunar Exploration: ADVANCE Program

    NASA Technical Reports Server (NTRS)

    Rojdev, Kristina

    2009-01-01

    This viewgraph presentation reviews the work that the author has been involved with in her undergraduate and graduate education and the ADVANCE Program. One project was the Lunar Entry and Approach Platform For Research On Ground (LEAPFROG). This vehicle was to be a completely autonomous vehicle, and was developed in successive academic years with increases in the perofmamnce and capability of the simulated lander. Another research project for the PhD was on long-term lunar radiation degradation of materials to be used for construction of lunar habitats. This research has concentrated on developing and testing light-weight composite materials with high strength characteristics, and the ability of these composite materials to withstand the lunar radiation environment.

  15. Editorial: Latest methods and advances in biotechnology.

    PubMed

    Lee, Sang Yup; Jungbauer, Alois

    2014-01-01

    The latest "Biotech Methods and Advances" special issue of Biotechnology Journal continues the BTJ tradition of featuring the latest breakthroughs in biotechnology. The special issue is edited by our Editors-in-Chief, Prof. Sang Yup Lee and Prof. Alois Jungbauer and covers a wide array of topics in biotechnology, including the perennial favorite workhorses of the biotech industry, Chinese hamster ovary (CHO) cell and Escherichia coli.

  16. Advances in neural networks research: an introduction.

    PubMed

    Kozma, Robert; Bressler, Steven; Perlovsky, Leonid; Venayagamoorthy, Ganesh Kumar

    2009-01-01

    The present Special Issue "Advances in Neural Networks Research: IJCNN2009" provides a state-of-art overview of the field of neural networks. It includes 39 papers from selected areas of the 2009 International Joint Conference on Neural Networks (IJCNN2009). IJCNN2009 took place on June 14-19, 2009 in Atlanta, Georgia, USA, and it represents an exemplary collaboration between the International Neural Networks Society and the IEEE Computational Intelligence Society. Topics in this issue include neuroscience and cognitive science, computational intelligence and machine learning, hybrid techniques, nonlinear dynamics and chaos, various soft computing technologies, intelligent signal processing and pattern recognition, bioinformatics and biomedicine, and engineering applications. PMID:19632811

  17. Advances in neural networks research: an introduction.

    PubMed

    Kozma, Robert; Bressler, Steven; Perlovsky, Leonid; Venayagamoorthy, Ganesh Kumar

    2009-01-01

    The present Special Issue "Advances in Neural Networks Research: IJCNN2009" provides a state-of-art overview of the field of neural networks. It includes 39 papers from selected areas of the 2009 International Joint Conference on Neural Networks (IJCNN2009). IJCNN2009 took place on June 14-19, 2009 in Atlanta, Georgia, USA, and it represents an exemplary collaboration between the International Neural Networks Society and the IEEE Computational Intelligence Society. Topics in this issue include neuroscience and cognitive science, computational intelligence and machine learning, hybrid techniques, nonlinear dynamics and chaos, various soft computing technologies, intelligent signal processing and pattern recognition, bioinformatics and biomedicine, and engineering applications.

  18. Advanced Energy Projects FY 1996 research summaries

    SciTech Connect

    1996-09-01

    The mission of the Advanced Energy Projects Division (AEP) is to explore the scientific feasibility of novel energy-related concepts. These concepts are typically at an early stage of scientific development and, therefore, are premature for consideration by applied research or technology development programs. The portfolio of projects is dynamic, but reflects the broad role of the Department in supporting research and development for improving the Nation`s energy posture. Topical areas presently receiving support include: alternative energy sources; innovative concepts for energy conversion and storage; alternate pathways to energy efficiency; exploring uses of new scientific discoveries; biologically-based energy concepts; renewable and biodegradable materials; novel materials for energy technology; and innovative approaches to waste treatment and reduction. Summaries of the 70 projects currently being supported are presented. Appendices contain budget information and investigator and institutional indices.

  19. Roadblocks to translational advances on metastasis research.

    PubMed

    Brabletz, Thomas; Lyden, David; Steeg, Patricia S; Werb, Zena

    2013-09-01

    Promising advances in cancer therapy stemming from an increasing understanding of the molecular and genetic underpinnings of the tumorigenic process have been fueled by a strong, determined scientific community, influential patient advocacy groups and committed funding bodies. Despite these efforts, the development of effective drugs to prevent systemic dissemination of cancer cells or to eliminate overt metastasis in secondary organs remains a challenge to both researchers and physicians. In an attempt to tackle the most relevant and timely translational issues, a meeting held in 2012 as a result of a successful partnership between the Volkswagen Foundation and Nature Medicine brought together a group of metastasis research experts to identify the most important hurdles and help create a framework for potential clinical and translational strategies. PMID:24013756

  20. Advanced Scientific Computing Research Network Requirements

    SciTech Connect

    Bacon, Charles; Bell, Greg; Canon, Shane; Dart, Eli; Dattoria, Vince; Goodwin, Dave; Lee, Jason; Hicks, Susan; Holohan, Ed; Klasky, Scott; Lauzon, Carolyn; Rogers, Jim; Shipman, Galen; Skinner, David; Tierney, Brian

    2013-03-08

    The Energy Sciences Network (ESnet) is the primary provider of network connectivity for the U.S. Department of Energy (DOE) Office of Science (SC), the single largest supporter of basic research in the physical sciences in the United States. In support of SC programs, ESnet regularly updates and refreshes its understanding of the networking requirements of the instruments, facilities, scientists, and science programs that it serves. This focus has helped ESnet to be a highly successful enabler of scientific discovery for over 25 years. In October 2012, ESnet and the Office of Advanced Scientific Computing Research (ASCR) of the DOE SC organized a review to characterize the networking requirements of the programs funded by the ASCR program office. The requirements identified at the review are summarized in the Findings section, and are described in more detail in the body of the report.

  1. Geysers advanced direct contact condenser research

    SciTech Connect

    Henderson, J.; Bahning, T.; Bharathan, D.

    1997-12-31

    The first geothermal application of the Advanced Direct Contact Condenser (ADCC) technology developed by the National Renewable Energy Laboratory (NREL) is now operational and is being tested at The Geysers Power Plant Unit 11. This major research effort is being supported through the combined efforts of NREL, The Department of Energy (DOE), and Pacific Gas and Electric (PG&E). NREL and PG&E have entered into a Cooperative Research And Development Agreement (CRADA) for a project to improve the direct-contact condenser performance at The Geysers Power Plant. This project is the first geothermal adaptation of an advanced condenser design developed for the Ocean Thermal Energy Conversion (OTEC) systems. PG&E expects this technology to improve power plant performance and to help extend the life of the steam field by using steam more efficiently. In accordance with the CRADA, no money is transferred between the contracting parties. In this case the Department of Energy is funding NREL for their efforts in this project and PG&E is contributing funds in kind. Successful application of this technology at The Geysers will provide a basis for NREL to continue to develop this technology for other geothermal and fossil power plant systems.

  2. Recent advances in color vision research.

    PubMed

    Buchanan-Smith, Hannah M

    2005-12-01

    The remarkable variation in color vision both among and within primate species is receiving increasing attention from geneticists, psychophysicists, physiologists, and behavioral ecologists. It is known that color vision ability affects foraging behavior. Color vision is also likely to have implications for predation avoidance, social behavior, mate choice, and group dynamics, and should also influence the choice of stimuli for cognitive experiments. Therefore, understanding the color vision of a study species is important and of particular significance to scientists studying species with polymorphic color vision (most platyrrhines and some strepsirrhines). The papers in this issue were inspired by a symposium held during the 20th Congress of the International Primatological Society at Turin, Italy, in August 2004. The aim of the symposium was to bring together research from a range of disciplines, using recent methodological advances in molecular, modeling, and experimental techniques, to help elucidate the evolution, ecological importance, and distribution of color vision genotypes and phenotypes. The symposium achieved its aim, and as with most research in expanding disciplines, there are surprises and many questions still to be answered. Further advances will be made using a combination of different approaches involving analyses at the level of molecu1es, types of cell and neural networks, detailed and long-term field work, modeling, and carefully controlled experimentation. PMID:16342071

  3. Transformative Mixed Methods Research

    ERIC Educational Resources Information Center

    Mertens, Donna M.

    2010-01-01

    Paradigms serve as metaphysical frameworks that guide researchers in the identification and clarification of their beliefs with regard to ethics, reality, knowledge, and methodology. The transformative paradigm is explained and illustrated as a framework for researchers who place a priority on social justice and the furtherance of human rights.…

  4. Advanced Bayesian Method for Planetary Surface Navigation

    NASA Technical Reports Server (NTRS)

    Center, Julian

    2015-01-01

    Autonomous Exploration, Inc., has developed an advanced Bayesian statistical inference method that leverages current computing technology to produce a highly accurate surface navigation system. The method combines dense stereo vision and high-speed optical flow to implement visual odometry (VO) to track faster rover movements. The Bayesian VO technique improves performance by using all image information rather than corner features only. The method determines what can be learned from each image pixel and weighs the information accordingly. This capability improves performance in shadowed areas that yield only low-contrast images. The error characteristics of the visual processing are complementary to those of a low-cost inertial measurement unit (IMU), so the combination of the two capabilities provides highly accurate navigation. The method increases NASA mission productivity by enabling faster rover speed and accuracy. On Earth, the technology will permit operation of robots and autonomous vehicles in areas where the Global Positioning System (GPS) is degraded or unavailable.

  5. Transnationalism: A Framework for Advancing Nursing Research With Contemporary Immigrants.

    PubMed

    Rosemberg, Marie-Anne S; Boutain, Doris M; Mohammed, Selina A

    2016-01-01

    This article advances nursing research by presenting transnationalism as a framework for inquiry with contemporary immigrants. Transnationalism occurs when immigrants maintain relationships that transcend the geographical borders of their origin and host countries. Immigrants use those relationships to experience health differently within concurrent socioeconomic, political, and cultural contexts than national situated populations. Nurse researchers are called upon to consider these trans-border relationships when exploring the health of contemporary immigrants. Such consideration is needed to develop relevant research designs, methods, analysis, and dissemination strategies. PMID:26836998

  6. Advanced digital methods for solid propellant burning rate determination

    NASA Astrophysics Data System (ADS)

    Jones, Daniel A.

    The work presented here is a study of a digital method for determining the combustion bomb burning rate of a fuel-rich gas generator propellant sample using the ultrasonic pulse-echo technique. The advanced digital method, which places user defined limits on the search for the ultrasonic echo from the burning surface, is computationally faster than the previous cross correlation method, and is able to analyze data for this class of propellant that the previous cross correlation data reduction method could not. For the conditions investigated, the best fit burning rate law at 800 psi from the ultrasonic technique and advanced cross correlation method is within 3 percent of an independent analysis of the same data, and is within 5 percent of the best fit burning rate law found from parallel research of the same propellant in a motor configuration.

  7. Recent advances in analytical methods for mycotoxins.

    PubMed

    Gilbert, J

    1993-01-01

    Recent advances in analytical methods are reviewed using the examples of aflatoxins and trichothecene mycotoxins. The most dramatic advances are seen as being those based on immunological principles utilized for aflatoxins to produce simple screening methods and for rapid specific clean-up. The possibilities of automation using immunoaffinity columns is described. In contrast for the trichothecenes immunological methods have not had the same general impact. Post-column derivatization using bromine or iodine to enhance fluorescence for HPLC detection of aflatoxins has become widely employed and there are similar possibilities for improved HPLC detection for trichothecenes using electrochemical or trichothecene-specific post-column reactions. There have been improvements in the use of more rapid and specific clean-up methods for trichothecenes, whilst HPLC and GC remain equally favoured for the end-determination. More sophisticated instrumental techniques such as mass spectrometry (LC/MS, MS/MS) and supercritical fluid chromatography (SFC/MS) have been demonstrated to have potential for application to mycotoxin analysis, but have not as yet made much general impact.

  8. Advanced Analysis Methods in High Energy Physics

    SciTech Connect

    Pushpalatha C. Bhat

    2001-10-03

    During the coming decade, high energy physics experiments at the Fermilab Tevatron and around the globe will use very sophisticated equipment to record unprecedented amounts of data in the hope of making major discoveries that may unravel some of Nature's deepest mysteries. The discovery of the Higgs boson and signals of new physics may be around the corner. The use of advanced analysis techniques will be crucial in achieving these goals. The author discusses some of the novel methods of analysis that could prove to be particularly valuable for finding evidence of any new physics, for improving precision measurements and for exploring parameter spaces of theoretical models.

  9. Advances in biomarker research for pancreatic cancer.

    PubMed

    Bhat, Kruttika; Wang, Fengfei; Ma, Qingyong; Li, Qinyu; Mallik, Sanku; Hsieh, Tze-Chen; Wu, Erxi

    2012-01-01

    Pancreatic cancer (PC) is a leading cause of cancer related deaths in United States. The lack of early symptoms results in latestage detection and a high mortality rate. Currently, the only potentially curative approach for PC is surgical resection, which is often unsuccessful because the invasive and metastatic nature of the tumor masses makes their complete removal difficult. Consequently, patients suffer relapses from remaining cancer stem cells or drug resistance that eventually lead to death. To improve the survival rate, the early detection of PC is critical. Current biomarker research in PC indicates that a serum carbohydrate antigen, CA 19-9, is the only available biomarker with approximately 90% specificity to PC. However, the efficacy of CA 19-9 for assessing prognosis and monitoring patients with PC remains contentious. Thus, advances in technology and the detection of new biomarkers with high specificity to PC are needed to reduce the mortality rate of pancreatic cancer.

  10. Advanced Materials for Exploration Task Research Results

    NASA Technical Reports Server (NTRS)

    Cook, M. B. (Compiler); Murphy, K. L.; Schneider, T.

    2008-01-01

    The Advanced Materials for Exploration (AME) Activity in Marshall Space Flight Center s (MSFC s) Exploration Science and Technology Directorate coordinated activities from 2001 to 2006 to support in-space propulsion technologies for future missions. Working together, materials scientists and mission planners identified materials shortfalls that are limiting the performance of long-term missions. The goal of the AME project was to deliver improved materials in targeted areas to meet technology development milestones of NASA s exploration-dedicated activities. Materials research tasks were targeted in five areas: (1) Thermal management materials, (2) propulsion materials, (3) materials characterization, (4) vehicle health monitoring materials, and (5) structural materials. Selected tasks were scheduled for completion such that these new materials could be incorporated into customer development plans.

  11. Addressing Risks to Advance Mental Health Research

    PubMed Central

    Iltis, Ana S.; Misra, Sahana; Dunn, Laura B.; Brown, Gregory K.; Campbell, Amy; Earll, Sarah A.; Glowinski, Anne; Hadley, Whitney B.; Pies, Ronald; DuBois, James M.

    2015-01-01

    Objective Risk communication and management are essential to the ethical conduct of research, yet addressing risks may be time consuming for investigators and institutional review boards (IRBs) may reject study designs that appear too risky. This can discourage needed research, particularly in higher risk protocols or those enrolling potentially vulnerable individuals, such as those with some level of suicidality. Improved mechanisms for addressing research risks may facilitate much needed psychiatric research. This article provides mental health researchers with practical approaches to: 1) identify and define various intrinsic research risks; 2) communicate these risks to others (e.g., potential participants, regulatory bodies, society); 3) manage these risks during the course of a study; and 4) justify the risks. Methods As part of a National Institute of Mental Health (NIMH)-funded scientific meeting series, a public conference and a closed-session expert panel meeting were held on managing and disclosing risks in mental health clinical trials. The expert panel reviewed the literature with a focus on empirical studies and developed recommendations for best practices and further research on managing and disclosing risks in mental health clinical trials. IRB review was not required because there were no human subjects. The NIMH played no role in developing or reviewing the manuscript. Results Challenges, current data, practical strategies, and topics for future research are addressed for each of four key areas pertaining to management and disclosure of risks in clinical trials: identifying and defining risks, communicating risks, managing risks during studies, and justifying research risks. Conclusions Empirical data on risk communication, managing risks, and the benefits of research can support the ethical conduct of mental health research and may help investigators better conceptualize and confront risks and to gain IRB approval. PMID:24173618

  12. Advances in Design-Based Research

    ERIC Educational Resources Information Center

    Svihla, Vanessa

    2014-01-01

    Design-based research (DBR) is a core methodology of the Learning Sciences. Historically rooted as a movement away from the methods of experimental psychology, it is a means to develop "humble" theory that takes into account numerous contextual effects for understanding how and why a design supported learning. DBR involves iterative…

  13. Activities of the Research Institute for Advanced Computer Science

    NASA Technical Reports Server (NTRS)

    Oliger, Joseph

    1994-01-01

    The Research Institute for Advanced Computer Science (RIACS) was established by the Universities Space Research Association (USRA) at the NASA Ames Research Center (ARC) on June 6, 1983. RIACS is privately operated by USRA, a consortium of universities with research programs in the aerospace sciences, under contract with NASA. The primary mission of RIACS is to provide research and expertise in computer science and scientific computing to support the scientific missions of NASA ARC. The research carried out at RIACS must change its emphasis from year to year in response to NASA ARC's changing needs and technological opportunities. Research at RIACS is currently being done in the following areas: (1) parallel computing; (2) advanced methods for scientific computing; (3) high performance networks; and (4) learning systems. RIACS technical reports are usually preprints of manuscripts that have been submitted to research journals or conference proceedings. A list of these reports for the period January 1, 1994 through December 31, 1994 is in the Reports and Abstracts section of this report.

  14. Advanced electromagnetic methods for aerospace vehicles

    NASA Technical Reports Server (NTRS)

    Balanis, Constantine A.; El-Sharawy, El-Budawy; Hashemi-Yeganeh, Shahrokh; Aberle, James T.; Birtcher, Craig R.

    1991-01-01

    The Advanced Helicopter Electromagnetics is centered on issues that advance technology related to helicopter electromagnetics. Progress was made on three major topics: composite materials; precipitation static corona discharge; and antenna technology. In composite materials, the research has focused on the measurements of their electrical properties, and the modeling of material discontinuities and their effect on the radiation pattern of antennas mounted on or near material surfaces. The electrical properties were used to model antenna performance when mounted on composite materials. Since helicopter platforms include several antenna systems at VHF and UHF bands, measuring techniques are being explored that can be used to measure the properties at these bands. The effort on corona discharge and precipitation static was directed toward the development of a new two dimensional Voltage Finite Difference Time Domain computer program. Results indicate the feasibility of using potentials for simulating electromagnetic problems in the cases where potentials become primary sources. In antenna technology the focus was on Polarization Diverse Conformal Microstrip Antennas, Cavity Backed Slot Antennas, and Varactor Tuned Circular Patch Antennas. Numerical codes were developed for the analysis of two probe fed rectangular and circular microstrip patch antennas fed by resistive and reactive power divider networks.

  15. Research Methods in Sociolinguistics

    ERIC Educational Resources Information Center

    Hernández-Campoy, Juan Manuel

    2014-01-01

    The development of Sociolinguistics has been qualitatively and quantitatively outstanding within Linguistic Science since its beginning in the 1950s, with a steady growth in both theoretical and methodological developments as well as in its interdisciplinary directions within the spectrum of language and society. Field methods in sociolinguistic…

  16. Advances in nicotine research in Addiction Biology.

    PubMed

    Bernardi, Rick E

    2015-09-01

    The aim of Addiction Biology is to advance our understanding of the action of drugs of abuse and addictive processes via the publication of high-impact clinical and pre-clinical findings resulting from behavioral, molecular, genetic, biochemical, neurobiological and pharmacological research. As of 2013, Addiction Biology is ranked number 1 in the category of Substance Abuse journals (SCI). Occasionally, Addiction Biology likes to highlight via review important findings focused on a particular topic and recently published in the journal. The current review summarizes a number of key publications from Addiction Biology that have contributed to the current knowledge of nicotine research, comprising a wide spectrum of approaches, both clinical and pre-clinical, at the cellular, molecular, systems and behavioral levels. A number of findings from human studies have identified, using imaging techniques, alterations in common brain circuits, as well as morphological and network activity changes, associated with tobacco use. Furthermore, both clinical and pre-clinical studies have characterized a number of mechanistic targets critical to understanding the effects of nicotine and tobacco addiction. Together, these findings will undoubtedly drive future studies examining the dramatic impact of tobacco use and the development of treatments to counter nicotine dependence. PMID:25997723

  17. Advances in nicotine research in Addiction Biology.

    PubMed

    Bernardi, Rick E

    2015-09-01

    The aim of Addiction Biology is to advance our understanding of the action of drugs of abuse and addictive processes via the publication of high-impact clinical and pre-clinical findings resulting from behavioral, molecular, genetic, biochemical, neurobiological and pharmacological research. As of 2013, Addiction Biology is ranked number 1 in the category of Substance Abuse journals (SCI). Occasionally, Addiction Biology likes to highlight via review important findings focused on a particular topic and recently published in the journal. The current review summarizes a number of key publications from Addiction Biology that have contributed to the current knowledge of nicotine research, comprising a wide spectrum of approaches, both clinical and pre-clinical, at the cellular, molecular, systems and behavioral levels. A number of findings from human studies have identified, using imaging techniques, alterations in common brain circuits, as well as morphological and network activity changes, associated with tobacco use. Furthermore, both clinical and pre-clinical studies have characterized a number of mechanistic targets critical to understanding the effects of nicotine and tobacco addiction. Together, these findings will undoubtedly drive future studies examining the dramatic impact of tobacco use and the development of treatments to counter nicotine dependence.

  18. [Research advances in wheat (Triticum aestivum) allelopathy].

    PubMed

    Zhang, Xiaoke; Jiang, Yong; Liang, Wenju; Kong, Chuihua

    2004-10-01

    Wheat (Triticum aestivum) is the main food crop in the world, and plays an important role in agricultural production. In order to enhance wheat yield, herbicides and germicides were intensively applied and made negative effects on the environment. Wheat possesses allelopathic potential for weed suppression and disease control through the release of secondary metabolites from its living plants or residues, which could avoid the environment pollution brought by herbicides and germicides. This paper reviewed the research advances in wheat allelopathy. Hydroxamic acids and phenolic acids are the predominant allelochemicals frequently reported which could produce plant natural defense against weed, pest and disease. The allelopathic activity of allelochemicals is determined not only by the allelochemicals, but also by the factors of inheritance, environment and biology. The retention, transportation and transformation processes of allelochemicals, and the relationship between wheat allelopathy and soil biota and its mechanism were seldom studied and still needed to be researched profoundly. Utilizing wheat allelopathy in plant protection, environment protection and crop breeding would improve the stress-resistance, yield and quality of wheat in agricultural production. PMID:15624846

  19. [Memorandum prevention research - research areas and methods].

    PubMed

    Walter, U; Nöcker, G; Plaumann, M; Linden, S; Pott, E; Koch, U; Pawils, S; Altgeld, T; Dierks, M L; Frahsa, A; Jahn, I; Krauth, C; Pomp, M; Rehaag, R; Robra, B P; Süß, W; Töppich, J; Trojan, A; von Unger, H; Wildner, M; Wright, M

    2012-10-01

    From 2004 to 2012, the German Ministry of Education and Research (BMBF) established its first funding programme for the promotion of prevention research. 60 projects on primary prevention and health promotion and the meta-project entitled "Cooperation for Sustainable Prevention Research" (KNP) received BMBF grants under this programme during this period. The experience and knowledge gained and recommendations arising from the research funded under this programme are compiled in memorandum format. The "Memorandum on Prevention Research - Research Areas and Methods" highlights 5 research areas that are considered to be especially relevant from the perspective of the involved scientists and practice partners.The promotion of structural development and sustainability enhancement in disease prevention and health promotion are central areas that should branch out from existing nuclei of crystallization. Improving the health competence of the population and of specific subpopulations is another major area. Research in these areas should contribute to the development of theoretical concepts and to the empirical testing of these concepts. The transfer of knowledge for effective use of developed disease prevention and health promotion programmes and measures is still a scarcely researched area. Among other things, studies of the transfer of programmes from one context to another, analyses of the coop-eration between politics and science, and the continued theoretical and conceptual development of transfer research are needed. Long-term data on the effects of intervention studies are also needed for proper evaluation of sustainability. The latter dem-onstrates the importance of method development in disease prevention and health promotion research as an area that should receive separate funding and support. This research should include, in particular, studies of the efficacy of complex interventions, health economic analyses, and participative health research. PMID:23165608

  20. Exploration of Advanced Probabilistic and Stochastic Design Methods

    NASA Technical Reports Server (NTRS)

    Mavris, Dimitri N.

    2003-01-01

    The primary objective of the three year research effort was to explore advanced, non-deterministic aerospace system design methods that may have relevance to designers and analysts. The research pursued emerging areas in design methodology and leverage current fundamental research in the area of design decision-making, probabilistic modeling, and optimization. The specific focus of the three year investigation was oriented toward methods to identify and analyze emerging aircraft technologies in a consistent and complete manner, and to explore means to make optimal decisions based on this knowledge in a probabilistic environment. The research efforts were classified into two main areas. First, Task A of the grant has had the objective of conducting research into the relative merits of possible approaches that account for both multiple criteria and uncertainty in design decision-making. In particular, in the final year of research, the focus was on the comparison and contrasting between three methods researched. Specifically, these three are the Joint Probabilistic Decision-Making (JPDM) technique, Physical Programming, and Dempster-Shafer (D-S) theory. The next element of the research, as contained in Task B, was focused upon exploration of the Technology Identification, Evaluation, and Selection (TIES) methodology developed at ASDL, especially with regards to identification of research needs in the baseline method through implementation exercises. The end result of Task B was the documentation of the evolution of the method with time and a technology transfer to the sponsor regarding the method, such that an initial capability for execution could be obtained by the sponsor. Specifically, the results of year 3 efforts were the creation of a detailed tutorial for implementing the TIES method. Within the tutorial package, templates and detailed examples were created for learning and understanding the details of each step. For both research tasks, sample files and

  1. Advances in nanostructured permanent magnets research

    SciTech Connect

    Poudyal, N; Liu, JP

    2012-12-14

    This paper reviews recent developments in research in nanostructured permanent magnets ( hard magnetic materials) with emphasis on bottom-up approaches to fabrication of hard/soft nanocomposite bulk magnets. Theoretical and experimental findings on the effects of soft phase and interface conditions on interphase exchange interactions are given. Synthesis techniques for hard magnetic nanoparticles, including chemical solution methods, surfactant-assisted ball milling and other physical deposition methods are reviewed. Processing and magnetic properties of warm compacted and plastically deformed bulk magnets with nanocrystalline morphology are discussed. Prospects of producing bulk anisotropic hard/soft nanocomposite magnets are presented.

  2. Conceptualizing and Advancing Research Networking Systems.

    PubMed

    Schleyer, Titus; Butler, Brian S; Song, Mei; Spallek, Heiko

    2012-03-01

    Science in general, and biomedical research in particular, is becoming more collaborative. As a result, collaboration with the right individuals, teams, and institutions is increasingly crucial for scientific progress. We propose Research Networking Systems (RNS) as a new type of system designed to help scientists identify and choose collaborators, and suggest a corresponding research agenda. The research agenda covers four areas: foundations, presentation, architecture, and evaluation. Foundations includes project-, institution- and discipline-specific motivational factors; the role of social networks; and impression formation based on information beyond expertise and interests. Presentation addresses representing expertise in a comprehensive and up-to-date manner; the role of controlled vocabularies and folksonomies; the tension between seekers' need for comprehensive information and potential collaborators' desire to control how they are seen by others; and the need to support serendipitous discovery of collaborative opportunities. Architecture considers aggregation and synthesis of information from multiple sources, social system interoperability, and integration with the user's primary work context. Lastly, evaluation focuses on assessment of collaboration decisions, measurement of user-specific costs and benefits, and how the large-scale impact of RNS could be evaluated with longitudinal and naturalistic methods. We hope that this article stimulates the human-computer interaction, computer-supported cooperative work, and related communities to pursue a broad and comprehensive agenda for developing research networking systems.

  3. Conceptualizing and Advancing Research Networking Systems

    PubMed Central

    SCHLEYER, TITUS; BUTLER, BRIAN S.; SONG, MEI; SPALLEK, HEIKO

    2013-01-01

    Science in general, and biomedical research in particular, is becoming more collaborative. As a result, collaboration with the right individuals, teams, and institutions is increasingly crucial for scientific progress. We propose Research Networking Systems (RNS) as a new type of system designed to help scientists identify and choose collaborators, and suggest a corresponding research agenda. The research agenda covers four areas: foundations, presentation, architecture, and evaluation. Foundations includes project-, institution- and discipline-specific motivational factors; the role of social networks; and impression formation based on information beyond expertise and interests. Presentation addresses representing expertise in a comprehensive and up-to-date manner; the role of controlled vocabularies and folksonomies; the tension between seekers’ need for comprehensive information and potential collaborators’ desire to control how they are seen by others; and the need to support serendipitous discovery of collaborative opportunities. Architecture considers aggregation and synthesis of information from multiple sources, social system interoperability, and integration with the user’s primary work context. Lastly, evaluation focuses on assessment of collaboration decisions, measurement of user-specific costs and benefits, and how the large-scale impact of RNS could be evaluated with longitudinal and naturalistic methods. We hope that this article stimulates the human-computer interaction, computer-supported cooperative work, and related communities to pursue a broad and comprehensive agenda for developing research networking systems. PMID:24376309

  4. Eagleworks Laboratories: Advanced Propulsion Physics Research

    NASA Technical Reports Server (NTRS)

    White, Harold; March, Paul; Williams, Nehemiah; ONeill, William

    2011-01-01

    NASA/JSC is implementing an advanced propulsion physics laboratory, informally known as "Eagleworks", to pursue propulsion technologies necessary to enable human exploration of the solar system over the next 50 years, and enabling interstellar spaceflight by the end of the century. This work directly supports the "Breakthrough Propulsion" objectives detailed in the NASA OCT TA02 In-space Propulsion Roadmap, and aligns with the #10 Top Technical Challenge identified in the report. Since the work being pursued by this laboratory is applied scientific research in the areas of the quantum vacuum, gravitation, nature of space-time, and other fundamental physical phenomenon, high fidelity testing facilities are needed. The lab will first implement a low-thrust torsion pendulum (<1 uN), and commission the facility with an existing Quantum Vacuum Plasma Thruster. To date, the QVPT line of research has produced data suggesting very high specific impulse coupled with high specific force. If the physics and engineering models can be explored and understood in the lab to allow scaling to power levels pertinent for human spaceflight, 400kW SEP human missions to Mars may become a possibility, and at power levels of 2MW, 1-year transit to Neptune may also be possible. Additionally, the lab is implementing a warp field interferometer that will be able to measure spacetime disturbances down to 150nm. Recent work published by White [1] [2] [3] suggests that it may be possible to engineer spacetime creating conditions similar to what drives the expansion of the cosmos. Although the expected magnitude of the effect would be tiny, it may be a "Chicago pile" moment for this area of physics.

  5. Advances in Mycotoxin Research: Public Health Perspectives.

    PubMed

    Lee, Hyun Jung; Ryu, Dojin

    2015-12-01

    Aflatoxins, ochratoxins, fumonisins, deoxynivalenol, and zearalenone are of significant public health concern as they can cause serious adverse effects in different organs including the liver, kidney, and immune system in humans. These toxic secondary metabolites are produced by filamentous fungi mainly in the genus Aspergillus, Penicillium, and Fusarium. It is challenging to control the formation of mycotoxins due to the worldwide occurrence of these fungi in food and the environment. In addition to raw agricultural commodities, mycotoxins tend to remain in finished food products as they may not be destroyed by conventional processing techniques. Hence, much of our concern is directed to chronic health effects through long-term exposure to one or multiple mycotoxins from contaminated foods. Ideally risk assessment requires a comprehensive data, including toxicological and epidemiological studies as well as surveillance and exposure assessment. Setting of regulatory limits for mycotoxins is considered necessary to protect human health from mycotoxin exposure. Although advances in analytical techniques provide basic yet critical tool in regulation as well as all aspects of scientific research, it has been acknowledged that different forms of mycotoxins such as analogs and conjugated mycotoxins may constitute a significant source of dietary exposure. Further studies should be warranted to correlate mycotoxin exposure and human health possibly via identification and validation of suitable biomarkers.

  6. [Research advances on interactions among bryophytes].

    PubMed

    Bu, Zhao-Jun; Chen, Xu; Jiang, Li-Hong; Li, Hong-Kai; Zhao, Hong-Yan

    2009-02-01

    This paper summarized the present research status and advances on the intra- and interspecific positive interaction, intra- and inter-specific competition, niche, and coexistence of bryophytes. Bryophytes are generally the dominant plants in harsh environments, and there is a trade-off between their water retention and light and nutrient resource availability. Because of the lesser importance of competition in harsh environments, the positive interaction among bryophytes is common, but the intra- and inter-specific competition among bryophytes and the competition between bryophytes and vascular plants are not rare. Competition hierarchy may exist among some bryophytes, but often changes with environments. In the process of bryophyte community formation, the random process, nature of colonization, and difference in regeneration strategy can result in the niche overlap and coexistence of bryophytes, and the niche differentiation resulted from competition is also one of the mechanisms for bryophytes coexistence. Bryophytes should not be simply classified as stress tolerated-ruderal life history strategists, and competition is still one of important factors for constructing some bryophyte communities and vegetations co-existed by bryophytes and vascular plants.

  7. Research Advances: Less Expensive and More Convenient Gaucher's Disease Treatment; Structural Loop Regions: Key to Multidrug-Resistance Transporters?; New Method Identifies Proteins in Old Artwork

    ERIC Educational Resources Information Center

    King, Angela G.

    2006-01-01

    The X-ray structure of EmrD, a multidrug transporter protein from Escherichia coli, common bacteria known to cause several food-borne illnesses was determined by scientists at The Scripps Research Institute. The hydrophobic residues in the EmrD internal cavity are likely to contribute to the general mechanism transporting various compounds through…

  8. Advanced fault diagnosis methods in molecular networks.

    PubMed

    Habibi, Iman; Emamian, Effat S; Abdi, Ali

    2014-01-01

    Analysis of the failure of cell signaling networks is an important topic in systems biology and has applications in target discovery and drug development. In this paper, some advanced methods for fault diagnosis in signaling networks are developed and then applied to a caspase network and an SHP2 network. The goal is to understand how, and to what extent, the dysfunction of molecules in a network contributes to the failure of the entire network. Network dysfunction (failure) is defined as failure to produce the expected outputs in response to the input signals. Vulnerability level of a molecule is defined as the probability of the network failure, when the molecule is dysfunctional. In this study, a method to calculate the vulnerability level of single molecules for different combinations of input signals is developed. Furthermore, a more complex yet biologically meaningful method for calculating the multi-fault vulnerability levels is suggested, in which two or more molecules are simultaneously dysfunctional. Finally, a method is developed for fault diagnosis of networks based on a ternary logic model, which considers three activity levels for a molecule instead of the previously published binary logic model, and provides equations for the vulnerabilities of molecules in a ternary framework. Multi-fault analysis shows that the pairs of molecules with high vulnerability typically include a highly vulnerable molecule identified by the single fault analysis. The ternary fault analysis for the caspase network shows that predictions obtained using the more complex ternary model are about the same as the predictions of the simpler binary approach. This study suggests that by increasing the number of activity levels the complexity of the model grows; however, the predictive power of the ternary model does not appear to be increased proportionally.

  9. Oil shale, tar sand, coal research, advanced exploratory process technology jointly sponsored research

    SciTech Connect

    Not Available

    1992-01-01

    Accomplishments for the quarter are presented for the following areas of research: oil shale, tar sand, coal, advanced exploratory process technology, and jointly sponsored research. Oil shale research includes; oil shale process studies, environmental base studies for oil shale, and miscellaneous basic concept studies. Tar sand research covers process development. Coal research includes; underground coal gasification, coal combustion, integrated coal processing concepts, and solid waste management. Advanced exploratory process technology includes; advanced process concepts, advanced mitigation concepts, and oil and gas technology. Jointly sponsored research includes: organic and inorganic hazardous waste stabilization; development and validation of a standard test method for sequential batch extraction fluid; operation and evaluation of the CO[sub 2] HUFF-N-PUFF Process; fly ash binder for unsurfaced road aggregates; solid state NMR analysis of Mesa Verde Group, Greater Green River Basin, tight gas sands; flow-loop testing of double-wall pipe for thermal applications; characterization of petroleum residue; shallow oil production using horizontal wells with enhanced recovery techniques; and menu driven access to the WDEQ Hydrologic Data Management Systems.

  10. 2010 Summary of Advances in Autism Spectrum Disorder Research

    ERIC Educational Resources Information Center

    Interagency Autism Coordinating Committee, 2010

    2010-01-01

    As part of the Combating Autism Act of 2006, the members of the Interagency Autism Coordinating Committee (IACC) are required to develop an annual "Summary of Advances" to describe each year's top advances in autism spectrum disorder (ASD) research. These advances represent significant progress in the early diagnosis of ASD, understanding the…

  11. 77 FR 19744 - Advanced BioPhotonics, Inc., Advanced Viral Research Corp., Brantley Capital Corp., Brilliant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-02

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Advanced BioPhotonics, Inc., Advanced Viral Research Corp., Brantley Capital Corp., Brilliant... information concerning the securities of Advanced BioPhotonics, Inc. because it has not filed any...

  12. Advanced research workshop: nuclear materials safety

    SciTech Connect

    Jardine, L J; Moshkov, M M

    1999-01-28

    The Advanced Research Workshop (ARW) on Nuclear Materials Safety held June 8-10, 1998, in St. Petersburg, Russia, was attended by 27 Russian experts from 14 different Russian organizations, seven European experts from six different organizations, and 14 U.S. experts from seven different organizations. The ARW was conducted at the State Education Center (SEC), a former Minatom nuclear training center in St. Petersburg. Thirty-three technical presentations were made using simultaneous translations. These presentations are reprinted in this volume as a formal ARW Proceedings in the NATO Science Series. The representative technical papers contained here cover nuclear material safety topics on the storage and disposition of excess plutonium and high enriched uranium (HEU) fissile materials, including vitrification, mixed oxide (MOX) fuel fabrication, plutonium ceramics, reprocessing, geologic disposal, transportation, and Russian regulatory processes. This ARW completed discussions by experts of the nuclear materials safety topics that were not covered in the previous, companion ARW on Nuclear Materials Safety held in Amarillo, Texas, in March 1997. These two workshops, when viewed together as a set, have addressed most nuclear material aspects of the storage and disposition operations required for excess HEU and plutonium. As a result, specific experts in nuclear materials safety have been identified, know each other from their participation in t he two ARW interactions, and have developed a partial consensus and dialogue on the most urgent nuclear materials safety topics to be addressed in a formal bilateral program on t he subject. A strong basis now exists for maintaining and developing a continuing dialogue between Russian, European, and U.S. experts in nuclear materials safety that will improve the safety of future nuclear materials operations in all the countries involved because of t he positive synergistic effects of focusing these diverse backgrounds of

  13. Cost estimating methods for advanced space systems

    NASA Technical Reports Server (NTRS)

    Cyr, Kelley

    1988-01-01

    Parametric cost estimating methods for space systems in the conceptual design phase are developed. The approach is to identify variables that drive cost such as weight, quantity, development culture, design inheritance, and time. The relationship between weight and cost is examined in detail. A theoretical model of cost is developed and tested statistically against a historical data base of major research and development programs. It is concluded that the technique presented is sound, but that it must be refined in order to produce acceptable cost estimates.

  14. Advanced continuous cultivation methods for systems microbiology.

    PubMed

    Adamberg, Kaarel; Valgepea, Kaspar; Vilu, Raivo

    2015-09-01

    Increasing the throughput of systems biology-based experimental characterization of in silico-designed strains has great potential for accelerating the development of cell factories. For this, analysis of metabolism in the steady state is essential as only this enables the unequivocal definition of the physiological state of cells, which is needed for the complete description and in silico reconstruction of their phenotypes. In this review, we show that for a systems microbiology approach, high-resolution characterization of metabolism in the steady state--growth space analysis (GSA)--can be achieved by using advanced continuous cultivation methods termed changestats. In changestats, an environmental parameter is continuously changed at a constant rate within one experiment whilst maintaining cells in the physiological steady state similar to chemostats. This increases the resolution and throughput of GSA compared with chemostats, and, moreover, enables following of the dynamics of metabolism and detection of metabolic switch-points and optimal growth conditions. We also describe the concept, challenge and necessary criteria of the systematic analysis of steady-state metabolism. Finally, we propose that such systematic characterization of the steady-state growth space of cells using changestats has value not only for fundamental studies of metabolism, but also for systems biology-based metabolic engineering of cell factories.

  15. Advanced Materials and Solids Analysis Research Core (AMSARC)

    EPA Science Inventory

    The Advanced Materials and Solids Analysis Research Core (AMSARC), centered at the U.S. Environmental Protection Agency's (EPA) Andrew W. Breidenbach Environmental Research Center in Cincinnati, Ohio, is the foundation for the Agency's solids and surfaces analysis capabilities. ...

  16. Advanced cogeneration research study: Executive summary

    NASA Technical Reports Server (NTRS)

    Bluhm, S. A.; Moore, N.; Rosenberg, L.; Slonski, M.

    1983-01-01

    This study provides a broad based overview of selected areas relevant to the development of a comprehensive Southern California Edison (SCE) advanced cogeneration project. The areas studied are: (1) Cogeneration potential in the SCE service territory; (2) Advanced cogeneration technologies; and (3) Existing cogeneration computer models. An estimated 3700 MW sub E could potentially be generated from existing industries in the Southern California Edison service territory using cogeneration technology. Of this total, current technology could provide 2600 MW sub E and advanced technology could provide 1100 MW sub E. The manufacturing sector (SIC Codes 20-39) was found to have the highest average potential for current cogeneration technology. The mining sector (SIC Codes 10-14) was found to have the highest potential for advanced technology.

  17. [Research advances in pediatric nonalcoholic fatty liver disease].

    PubMed

    Dai, Dong-Ling

    2015-01-01

    In recent years, nonalcoholic fatty liver disease (NAFLD) has increased because of the growing prevalence of obesity and overweight in the pediatric population. It has become the most common form of chronic liver diseases in children and the related research on NAFLD is expanded. The "two-hit" and "multiple hit" hypothesis have been widely accepted, and some research has shown that genetic, diet structure and environmental factors appear to play a crucial role in the development of pediatric NAFLD. Though it is expected by researchers, there is not an available satisfactory noninvasive marker for the diagnosis of this disease. Fortunately, some new non-invasive prediction scores for pediatric NAFLD have been developed. There is currently no established special therapy, and lifestyle intervention should be adequate for most cases of NAFLD in children. This article reviews the advances in the current knowledge and ideas concerning pediatric NAFLD, and discusses the diagnosis, perspective therapies and scoring methods for this disease.

  18. Impact of new instrumentation on advanced turbine research

    NASA Technical Reports Server (NTRS)

    Graham, R. W.

    1980-01-01

    A description is presented of an orderly test program that progresses from the simplest stationary geometry to the more complex, three dimensional, rotating turbine stage. The instrumentation requirements for this evolution of testing are described. The heat transfer instrumentation is emphasized. Recent progress made in devising new measurement techniques has greatly improved the development and confirmation of more accurate analytical methods for the prediction of turbine performance and heat transfer. However, there remain challenging requirements for novel measurement techniques that could advance the future research to be done in rotating blade rows of turbomachines.

  19. Ethics, Professional Expectations, and Graduate Education: Advancing Research in Kinesiology

    ERIC Educational Resources Information Center

    DePauw, Karen P.

    2009-01-01

    The university is a social institution and as such has a social responsibility to advance knowledge through research that is ultimately meaningful and beneficial to society. As we seek to advance research and graduate education in kinesiology, we must accept ethical standards and professional expectations not only as an institutional value but as…

  20. Advanced Electromagnetic Methods for Aerospace Vehicles

    NASA Technical Reports Server (NTRS)

    Balanis, Constantine A.; Polycarpou, Anastasis; Birtcher, Craig R.; Georgakopoulos, Stavros; Han, Dong-Ho; Ballas, Gerasimos

    1999-01-01

    The imminent destructive threats of Lightning on helicopters and other airborne systems has always been a topic of great interest to this research grant. Previously, the lightning induced currents on the surface of the fuselage and its interior were predicted using the finite-difference time-domain (FDTD) method as well as the NEC code. The limitations of both methods, as applied to lightning, were identified and extensively discussed in the last meeting. After a thorough investigation of the capabilities of the FDTD, it was decided to incorporate into the numerical method a subcell model to accurately represent current diffusion through conducting materials of high conductivity and finite thickness. Because of the complexity of the model, its validity will be first tested for a one-dimensional FDTD problem. Although results are not available yet, the theory and formulation of the subcell model are presented and discussed here to a certain degree. Besides lightning induced currents in the interior of an aircraft, penetration of electromagnetic fields through apertures (e.g., windows and cracks) could also be devastating for the navigation equipment, electronics, and communications systems in general. The main focus of this study is understanding and quantifying field penetration through apertures. The simulation is done using the FDTD method and the predictions are compared with measurements and moment method solutions obtained from the NASA Langley Research Center. Cavity-backed slot (CBS) antennas or slot antennas in general have many applications in aircraft-satellite type of communications. These can be flushmounted on the surface of the fuselage and, therefore, they retain the aerodynamic shape of the aircraft. In the past, input impedance and radiation patterns of CBS antennas were computed using a hybrid FEM/MoM code. The analysis is now extended to coupling between two identical slot antennas mounted on the same structure. The predictions are performed

  1. FINAL REPORT: Adopting Biophysics Methods in Pursuit of Biogeophysical Research: Advancing the Measurement and Modeling of Electrical Signatures of Microbe-Mineral Transformations Impacting Contaminant Transport

    SciTech Connect

    PRODAN, CAMELIA; SLATER, LEE; NTARLAGIANNIS, DIMITRIOS

    2012-09-01

    This exploratory project involved laboratory experiments to investigate three hypotheses: (H1) Physics-based modeling of low-frequency dispersions (henceforth referred to as alpha) measured in broadband dielectric spectroscopy (DS) data can quantify pore-scale geometric changes impacting contaminant transport resulting from biomineralization; (H2) Physics-based modeling of high-frequency dispersions (henceforth referred to as beta) measured in broadband dielectric spectroscopy data can quantify rates of mineral growth in/on the cell wall; (H3) Application of this measurement and modeling approach can enhance geophysical interpretation of bioremediation experiments conducted at the RIFLE IFC by providing constraints on bioremediation efficiency (biomass concentration, mineral uptake within the cell wall, biomineralization rate). We tested H1 by performing DS measurements (alpha and beta range) on iron (Fe) particles of dimensions similar to microbial cells, dispersed within agar gels over a range of Fe concentrations. We have tested the ability of the physics-based modeling to predict volume concentrations of the Fe particles by assuming that the Fe particles are polarizable inclusions within an otherwise nonpolarizable medium. We evaluated the smallest volume concentration that can be detected with the DS method. Similar experiments and modeling have been performed on the sulfate-reducing bacteria D. vulgaris. Synchrotron x-ray absorption measurements were conducted to determine the local structure of biominerals coatings on D. vulgaris which were grown in the presence of different Fe concentrations. We imaged the mineral growth on cell wall using SEM. We used dielectric spectroscopy to differentiate between iron sulfide precipitates of biotic and abiotic nature. Biotic measurements were made on D. vulgaris bacteria grown in the presence of different concentrations of iron to form different thicknesses of iron sulfide precipitates around themselves and abiotic

  2. Adopting Biophysics Methods in Pursuit of Biogeophysical Research: Advancing the measurement and modeling of electrical signatures of microbe-mineral transformations impacting contaminant transport

    SciTech Connect

    Prodan, Camelia

    2013-06-14

    This exploratory project involved laboratory experiments to investigate three hypotheses: (H1) Physics-based modeling of low-frequency dispersions (henceforth referred to as alpha) measured in broadband dielectric spectroscopy (DS) data can quantify pore-scale geometric changes impacting contaminant transport resulting from biomineralization; (H2) Physics-based modeling of high-frequency dispersions (henceforth referred to as beta) measured in broadband dielectric spectroscopy data can quantify rates of mineral growth in/on the cell wall; (H3) Application of this measurement and modeling approach can enhance geophysical interpretation of bioremediation experiments conducted at the RIFLE IFC by providing constraints on bioremediation efficiency (biomass concentration, mineral uptake within the cell wall, biomineralization rate). We tested H1 by performing DS measurements (alpha and beta range) on iron (Fe) particles of dimensions similar to microbial cells, dispersed within agar gels over a range of Fe concentrations. We have tested the ability of the physics-based modeling to predict volume concentrations of the Fe particles by assuming that the Fe particles are polarizable inclusions within an otherwise nonpolarizable medium. We evaluated the smallest volume concentration that can be detected with the DS method. Similar experiments and modeling have been performed on the sulfate-reducing bacteria D. vulgaris. Synchrotron x-ray absorption measurements were conducted to determine the local structure of biominerals coatings on D. vulgaris which were grown in the presence of different Fe concentrations. We imaged the mineral growth on cell wall using SEM. We used dielectric spectroscopy to differentiate between iron sulfide precipitates of biotic and abiotic nature. Biotic measurements were made on D. vulgaris bacteria grown in the presence of different concentrations of iron to form different thicknesses of iron sulfide precipitates around themselves and abiotic

  3. Advances in Education Research, Fall 1998.

    ERIC Educational Resources Information Center

    Craig, Judy A., Ed.

    1998-01-01

    This report provides peer-reviewed, scholarly research supported in whole or in part by the Office of Educational Research and Improvement through its educational research and development programs. It includes 13 previously published articles from selected refereed journals identifying the best research on community service learning. Section 1,…

  4. Mixed-Methods Research Methodologies

    ERIC Educational Resources Information Center

    Terrell, Steven R.

    2012-01-01

    Mixed-Method studies have emerged from the paradigm wars between qualitative and quantitative research approaches to become a widely used mode of inquiry. Depending on choices made across four dimensions, mixed-methods can provide an investigator with many design choices which involve a range of sequential and concurrent strategies. Defining…

  5. Integrated Advanced Energy Systems Research at IIT

    SciTech Connect

    Hamid Arastoopour

    2010-09-30

    This report consists of Two research projects; Sustainable Buildings and Hydrogen Storage. Sustainable Building Part includes: Wind and the self powered built environment by professor P. Land and his research group and experimental and computational works by professor D. Rempfer and his research group. Hydrogen Storage part includes: Hydrogen Storage Using Mg-Mixed Metal Hydrides by professor H. Arastoopour and his research team and Carbon Nanostructure as Hydrogen Storage Material by professor J. Prakash and his research team.

  6. Computational structural mechanics methods research using an evolving framework

    NASA Technical Reports Server (NTRS)

    Knight, N. F., Jr.; Lotts, C. G.; Gillian, R. E.

    1990-01-01

    Advanced structural analysis and computational methods that exploit high-performance computers are being developed in a computational structural mechanics research activity sponsored by the NASA Langley Research Center. These new methods are developed in an evolving framework and applied to representative complex structural analysis problems from the aerospace industry. An overview of the methods development environment is presented, and methods research areas are described. Selected application studies are also summarized.

  7. Advances in organometallic synthesis with mechanochemical methods.

    PubMed

    Rightmire, Nicholas R; Hanusa, Timothy P

    2016-02-14

    Solvent-based syntheses have long been normative in all areas of chemistry, although mechanochemical methods (specifically grinding and milling) have been used to good effect for decades in organic, and to a lesser but growing extent, inorganic coordination chemistry. Organometallic synthesis, in contrast, represents a relatively underdeveloped area for mechanochemical research, and the potential benefits are considerable. From access to new classes of unsolvated complexes, to control over stoichiometries that have not been observed in solution routes, mechanochemical (or 'M-chem') approaches have much to offer the synthetic chemist. It has already become clear that removing the solvent from an organometallic reaction can change reaction pathways considerably, so that prediction of the outcome is not always straightforward. This Perspective reviews recent developments in the field, and describes equipment that can be used in organometallic synthesis. Synthetic chemists are encouraged to add mechanochemical methods to their repertoire in the search for new and highly reactive metal complexes and novel types of organometallic transformations.

  8. Advanced Virtual Reality Simulations in Aerospace Education and Research

    NASA Astrophysics Data System (ADS)

    Plotnikova, L.; Trivailo, P.

    2002-01-01

    Recent research developments at Aerospace Engineering, RMIT University have demonstrated great potential for using Virtual Reality simulations as a very effective tool in advanced structures and dynamics applications. They have also been extremely successful in teaching of various undergraduate and postgraduate courses for presenting complex concepts in structural and dynamics designs. Characteristic examples are related to the classical orbital mechanics, spacecraft attitude and structural dynamics. Advanced simulations, reflecting current research by the authors, are mainly related to the implementation of various non-linear dynamic techniques, including using Kane's equations to study dynamics of space tethered satellite systems and the Co-rotational Finite Element method to study reconfigurable robotic systems undergoing large rotations and large translations. The current article will describe the numerical implementation of the modern methods of dynamics, and will concentrate on the post-processing stage of the dynamic simulations. Numerous examples of building Virtual Reality stand-alone animations, designed by the authors, will be discussed in detail. These virtual reality examples will include: The striking feature of the developed technology is the use of the standard mathematical packages, like MATLAB, as a post-processing tool to generate Virtual Reality Modelling Language files with brilliant interactive, graphics and audio effects. These stand-alone demonstration files can be run under Netscape or Microsoft Explorer and do not require MATLAB. Use of this technology enables scientists to easily share their results with colleagues using the Internet, contributing to the flexible learning development at schools and Universities.

  9. Further advances in orchid mycorrhizal research.

    PubMed

    Dearnaley, John D W

    2007-09-01

    Orchid mycorrhizas are mutualistic interactions between fungi and members of the Orchidaceae, the world's largest plant family. The majority of the world's orchids are photosynthetic, a small number of species are myco-heterotrophic throughout their lifetime, and recent research indicates a third mode (mixotrophy) whereby green orchids supplement their photosynthetically fixed carbon with carbon derived from their mycorrhizal fungus. Molecular identification studies of orchid-associated fungi indicate a wide range of fungi might be orchid mycobionts, show common fungal taxa across the globe and support the view that some orchids have specific fungal interactions. Confirmation of mycorrhizal status requires isolation of the fungi and restoration of functional mycorrhizas. New methods may now be used to store orchid-associated fungi and store and germinate seed, leading to more efficient culture of orchid species. However, many orchid mycorrhizas must be synthesised before conservation of these associations can be attempted in the field. Further gene expression studies of orchid mycorrhizas are needed to better understand the establishment and maintenance of the interaction. These data will add to efforts to conserve this diverse and valuable association. PMID:17582535

  10. Advances in Education Research, Fall 1999.

    ERIC Educational Resources Information Center

    Advances in Education Research, 1999

    1999-01-01

    This volume presents selected research articles related to early intervention for college programs. This is part of a two volume set designed to showcase some of the best cutting edge research on early intervention programs. Providing an introduction to the types of these programs, this issue: presents research on why the programs are necessary;…

  11. [Research advances in methyl bromide in the ocean].

    PubMed

    Du, Hui-na; Xie, Wen-xia; Cui, Yu-qian; Chen, Jian-lei; Ye, Si-yuan

    2014-12-01

    Methyl bromide is an important atmospheric trace gas, which plays significant roles in the global warming and atmospheric chemistry. The ocean plays important and complex roles in the global biogeochemical cycles of methyl bromide, not only the source of atmospheric methyl bromide, but also the sink. Therefore, developing the chemical research of the soluble methyl bromide in the ocean, will not only have a certain guiding significance to the atmospheric ozone layer protection, but also provide a theoretical basis for estimating methyl bromide's contribution to the global environmental change on global scale. This paper reviewed the research advances on methyl bromide in the ocean, from the aspects of the biogeochemical cycle of methyl bromide in the ocean, the analysis and determination method, the concentration distribution, the sea-to-air flux and its sources and sinks in the atmosphere. Some deficiencies in the current studies were put forward, and the directions of the future studies were prospected. PMID:25876424

  12. [Research advances in methyl bromide in the ocean].

    PubMed

    Du, Hui-na; Xie, Wen-xia; Cui, Yu-qian; Chen, Jian-lei; Ye, Si-yuan

    2014-12-01

    Methyl bromide is an important atmospheric trace gas, which plays significant roles in the global warming and atmospheric chemistry. The ocean plays important and complex roles in the global biogeochemical cycles of methyl bromide, not only the source of atmospheric methyl bromide, but also the sink. Therefore, developing the chemical research of the soluble methyl bromide in the ocean, will not only have a certain guiding significance to the atmospheric ozone layer protection, but also provide a theoretical basis for estimating methyl bromide's contribution to the global environmental change on global scale. This paper reviewed the research advances on methyl bromide in the ocean, from the aspects of the biogeochemical cycle of methyl bromide in the ocean, the analysis and determination method, the concentration distribution, the sea-to-air flux and its sources and sinks in the atmosphere. Some deficiencies in the current studies were put forward, and the directions of the future studies were prospected.

  13. Medical technology advances from space research.

    NASA Technical Reports Server (NTRS)

    Pool, S. L.

    1971-01-01

    NASA-sponsored medical R & D programs for space applications are reviewed with particular attention to the benefits of these programs to earthbound medical services and to the general public. Notable among the results of these NASA programs is an integrated medical laboratory equipped with numerous advanced systems such as digital biotelemetry and automatic visual field mapping systems, sponge electrode caps for electroencephalograms, and sophisticated respiratory analysis equipment.

  14. Advanced Radioisotope Power Systems Segmented Thermoelectric Research

    NASA Technical Reports Server (NTRS)

    Caillat, Thierry

    2004-01-01

    Flight times are long; - Need power systems with >15 years life. Mass is at an absolute premium; - Need power systems with high specific power and scalability. 3 orders of magnitude reduction in solar irradiance from Earth to Pluto. Nuclear power sources preferable. The Overall objective is to develop low mass, high efficiency, low-cost Advanced Radioisotope Power System with double the Specific Power and Efficiency over state-of-the-art Radioisotope Thermoelectric Generators (RTGs).

  15. Quantitative vs qualitative research methods.

    PubMed

    Lakshman, M; Sinha, L; Biswas, M; Charles, M; Arora, N K

    2000-05-01

    Quantitative methods have been widely used because of the fact that things that can be measured or counted gain scientific credibility over the unmeasurable. But the extent of biological abnormality, severity, consequences and the impact of illness cannot be satisfactorily captured and answered by the quantitative research alone. In such situations qualitative methods take a holistic perspective preserving the complexities of human behavior by addressing the "why" and "how" questions. In this paper an attempt has been made to highlight the strengths and weaknesses of both the methods and also that a balanced mix of both qualitative as well as quantitative methods yield the most valid and reliable results.

  16. Decomposition methods in turbulence research

    NASA Astrophysics Data System (ADS)

    Uruba, Václav

    2012-04-01

    Nowadays we have the dynamical velocity vector field of turbulent flow at our disposal coming thanks advances of either mathematical simulation (DNS) or of experiment (time-resolved PIV). Unfortunately there is no standard method for analysis of such data describing complicated extended dynamical systems, which is characterized by excessive number of degrees of freedom. An overview of candidate methods convenient to spatiotemporal analysis for such systems is to be presented. Special attention will be paid to energetic methods including Proper Orthogonal Decomposition (POD) in regular and snapshot variants as well as the Bi-Orthogonal Decomposition (BOD) for joint space-time analysis. Then, stability analysis using Principal Oscillation Patterns (POPs) will be introduced. Finally, the Independent Component Analysis (ICA) method will be proposed for detection of coherent structures in turbulent flow-field defined by time-dependent velocity vector field. Principle and some practical aspects of the methods are to be shown. Special attention is to be paid to physical interpretation of outputs of the methods listed above.

  17. Cost estimating methods for advanced space systems

    NASA Technical Reports Server (NTRS)

    Cyr, Kelley

    1994-01-01

    NASA is responsible for developing much of the nation's future space technology. Cost estimates for new programs are required early in the planning process so that decisions can be made accurately. Because of the long lead times required to develop space hardware, the cost estimates are frequently required 10 to 15 years before the program delivers hardware. The system design in conceptual phases of a program is usually only vaguely defined and the technology used is so often state-of-the-art or beyond. These factors combine to make cost estimating for conceptual programs very challenging. This paper describes an effort to develop parametric cost estimating methods for space systems in the conceptual design phase. The approach is to identify variables that drive cost such as weight, quantity, development culture, design inheritance and time. The nature of the relationships between the driver variables and cost will be discussed. In particular, the relationship between weight and cost will be examined in detail. A theoretical model of cost will be developed and tested statistically against a historical database of major research and development projects.

  18. Advanced Life Support Research and Technology Development

    NASA Technical Reports Server (NTRS)

    Kliss, Mark

    2001-01-01

    A videograph outlining life support research. The Human Exploration and Development of Space (HEDS) Enterprise's goals are to provide life support self-sufficiency for human beings to carry out research and exploration productively in space, to open the door for planetary exploration, and for benefits on Earth. Topics presented include the role of NASA Ames, funding, and technical monitoring. The focused research areas discussed include air regeneration, carbon dioxide removal, Mars Life Support, water recovery, Vapor Phase Catalytic Ammonia Removal (VPCAR), solid waste treatment, and Supercritical Water Oxidation (SCWC). Focus is placed on the utilization of Systems Integration, Modeling and Analysis (SIMA) and Dynamic Systems Modeling in this research.

  19. Research opportunities to advance solar energy utilization.

    PubMed

    Lewis, Nathan S

    2016-01-22

    Major developments, as well as remaining challenges and the associated research opportunities, are evaluated for three technologically distinct approaches to solar energy utilization: solar electricity, solar thermal, and solar fuels technologies. Much progress has been made, but research opportunities are still present for all approaches. Both evolutionary and revolutionary technology development, involving foundational research, applied research, learning by doing, demonstration projects, and deployment at scale will be needed to continue this technology-innovation ecosystem. Most of the approaches still offer the potential to provide much higher efficiencies, much lower costs, improved scalability, and new functionality, relative to the embodiments of solar energy-conversion systems that have been developed to date.

  20. Advanced research in solar-energy storage

    SciTech Connect

    Luft, W.

    1983-01-01

    The Solar Energy Storage Program at the Solar Energy Research Institute is reviewed. The program provides research, systems analyses, and economic assessments of thermal and thermochemical energy storage and transport. Current activities include experimental research into very high temperature (above 800/sup 0/C) thermal energy storage and assessment of novel thermochemical energy storage and transport systems. The applications for such high-temperature storage are thermochemical processes, solar thermal-electric power generation, cogeneration of heat and electricity, industrial process heat, and thermally regenerative electrochemical systems. The research results for five high-temperature thermal energy storage technologies and two thermochemical systems are described.

  1. Astonishing advances in mouse genetic tools for biomedical research.

    PubMed

    Kaczmarczyk, Lech; Jackson, Walker S

    2015-01-01

    The humble house mouse has long been a workhorse model system in biomedical research. The technology for introducing site-specific genome modifications led to Nobel Prizes for its pioneers and opened a new era of mouse genetics. However, this technology was very time-consuming and technically demanding. As a result, many investigators continued to employ easier genome manipulation methods, though resulting models can suffer from overlooked or underestimated consequences. Another breakthrough, invaluable for the molecular dissection of disease mechanisms, was the invention of high-throughput methods to measure the expression of a plethora of genes in parallel. However, the use of samples containing material from multiple cell types could obfuscate data, and thus interpretations. In this review we highlight some important issues in experimental approaches using mouse models for biomedical research. We then discuss recent technological advances in mouse genetics that are revolutionising human disease research. Mouse genomes are now easily manipulated at precise locations thanks to guided endonucleases, such as transcription activator-like effector nucleases (TALENs) or the CRISPR/Cas9 system, both also having the potential to turn the dream of human gene therapy into reality. Newly developed methods of cell type-specific isolation of transcriptomes from crude tissue homogenates, followed by detection with next generation sequencing (NGS), are vastly improving gene regulation studies. Taken together, these amazing tools simplify the creation of much more accurate mouse models of human disease, and enable the extraction of hitherto unobtainable data. PMID:26513700

  2. Astonishing advances in mouse genetic tools for biomedical research.

    PubMed

    Kaczmarczyk, Lech; Jackson, Walker S

    2015-01-01

    The humble house mouse has long been a workhorse model system in biomedical research. The technology for introducing site-specific genome modifications led to Nobel Prizes for its pioneers and opened a new era of mouse genetics. However, this technology was very time-consuming and technically demanding. As a result, many investigators continued to employ easier genome manipulation methods, though resulting models can suffer from overlooked or underestimated consequences. Another breakthrough, invaluable for the molecular dissection of disease mechanisms, was the invention of high-throughput methods to measure the expression of a plethora of genes in parallel. However, the use of samples containing material from multiple cell types could obfuscate data, and thus interpretations. In this review we highlight some important issues in experimental approaches using mouse models for biomedical research. We then discuss recent technological advances in mouse genetics that are revolutionising human disease research. Mouse genomes are now easily manipulated at precise locations thanks to guided endonucleases, such as transcription activator-like effector nucleases (TALENs) or the CRISPR/Cas9 system, both also having the potential to turn the dream of human gene therapy into reality. Newly developed methods of cell type-specific isolation of transcriptomes from crude tissue homogenates, followed by detection with next generation sequencing (NGS), are vastly improving gene regulation studies. Taken together, these amazing tools simplify the creation of much more accurate mouse models of human disease, and enable the extraction of hitherto unobtainable data.

  3. Ozone Research with Advanced Cooperative Lidar Experiment (ORACLE) Implementation Study

    NASA Technical Reports Server (NTRS)

    Stadler, John H.; Browell, Edward V.; Ismail, Syed; Dudelzak, Alexander E.; Ball, Donald J.

    1998-01-01

    New technological advances have made possible new active remote sensing capabilities from space. Utilizing these technologies, the Ozone Research with Advanced Cooperative Lidar Experiment (ORACLE) will provide high spatial resolution measurements of ozone, clouds and aerosols in the stratosphere and lower troposphere. Simultaneous measurements of ozone, clouds and aerosols will assist in the understanding of global change, atmospheric chemistry and meteorology.

  4. Advanced technology airfoil research, volume 2. [conferences

    NASA Technical Reports Server (NTRS)

    1979-01-01

    A comprehensive review of airfoil research is presented. The major thrust of the research is in three areas: development of computational aerodynamic codes for airfoil analysis and design, development of experimental facilities and test techniques, and all types of airfoil applications.

  5. Advancing Administrative Supports for Research Development

    ERIC Educational Resources Information Center

    Briar-Lawson, Katharine; Korr, Wynne; White, Barbara; Vroom, Phyllis; Zabora, James; Middleton, Jane; Shank, Barbara; Schatz, Mona

    2008-01-01

    Research administrative supports must parallel and reinforce faculty initiatives in research grant procurement. This article features several types of developments that draw on presentations at the National Association of Deans and Directors of Schools of Social Work meetings. Key changes in social work programs are addressed, including the…

  6. Research and Development: Advances in Education.

    ERIC Educational Resources Information Center

    Office of Education (DHEW), Washington, DC. Bureau of Research.

    This document presents vignettes illustrating improvements in learning resulting from educational innovations developed through research sponsored by the Cooperative Research Act of 1954, the National Defense Education Act of 1958, the Vocational Education Act of 1963, the Higher Education Act of 1965, and the Elementary and Secondary Education…

  7. Special Education Research Advances Knowledge in Education

    ERIC Educational Resources Information Center

    Vaughn, Sharon; Swanson, Elizabeth A.

    2015-01-01

    Research in special education has yielded beneficial outcomes for students with disabilities as well as typical achieving students. The authors provide examples of the valuable knowledge special education research has generated, including the elements of response to intervention (e.g., screening and progress monitoring), instructional practices…

  8. Methodological Advances in Uses and Gratifications Research.

    ERIC Educational Resources Information Center

    Becker, Lee B.

    One of the most difficult problems facing scholars interested in conducting empirical research concerning the gratification that audience members seek or receive from the media is measurement of gratification itself. This paper outlines the strategies commonly used by researchers and describes some of the limitations of each. Particular attention…

  9. Japanese advances in fuzzy systems research

    NASA Astrophysics Data System (ADS)

    Schwartz, Daniel G.

    1992-07-01

    During this past summer (1991), I spent two months on an appointment as visiting researcher at Kansai University, Osaka, Japan, and five weeks at the Laboratory for International Fuzzy Engineering Research (LIFE), in Yokohama. Part of the expenses for the time in Osaka, and all the expenses for the visit at LIFE, were covered by ONR. While there I met with most of the key researchers in both fuzzy systems and case-based reasoning. This involved trips to numerous universities and research laboratories at Matsushita/Panasonic, Omron, and Hitachi Corporations. In addition, I spent three days at the Fuzzy Logic Systems Institute (FLSI), Iizuka, and I attended the annual meeting of the Japan Society for Fuzzy Theory and Research (SOFT-91) in Nagoya. The following report elaborates what I learned as a result of those activities.

  10. Method and apparatus for advancing tethers

    DOEpatents

    Zollinger, W.T.

    1998-06-02

    A tether puller for advancing a tether through a channel may include a bellows assembly having a leading end fixedly attached to the tether at a first position and a trailing end fixedly attached to the tether at a second position so that the leading and trailing ends of the bellows assembly are located a substantially fixed distance apart. The bellows assembly includes a plurality of independently inflatable elements each of which may be separately inflated to an extended position and deflated to a retracted position. Each of the independently inflatable elements expands radially and axially upon inflation. An inflation system connected to the independently inflatable elements inflates and deflates selected ones of the independently inflatable elements to cause the bellows assembly to apply a tractive force to the tether and advance it in the channel. 9 figs.

  11. Method and apparatus for advancing tethers

    DOEpatents

    Zollinger, W. Thor

    1998-01-01

    A tether puller for advancing a tether through a channel may include a bellows assembly having a leading end fixedly attached to the tether at a first position and a trailing end fixedly attached to the tether at a second position so that the leading and trailing ends of the bellows assembly are located a substantially fixed distance apart. The bellows assembly includes a plurality of independently inflatable elements each of which may be separately inflated to an extended position and deflated to a retracted position. Each of the independently inflatable elements expands radially and axially upon inflation. An inflation system connected to the independently inflatable elements inflates and deflates selected ones of the independently inflatable elements to cause the bellows assembly to apply a tractive force to the tether and advance it in the channel.

  12. Prostate Cancer Stem Cells: Research Advances

    PubMed Central

    Jaworska, Dagmara; Król, Wojciech; Szliszka, Ewelina

    2015-01-01

    Cancer stem cells have been defined as cells within a tumor that possesses the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor. Experimental evidence showed that these highly tumorigenic cells might be responsible for initiation and progression of cancer into invasive and metastatic disease. Eradicating prostate cancer stem cells, the root of the problem, has been considered as a promising target in prostate cancer treatment to improve the prognosis for patients with advanced stages of the disease. PMID:26593898

  13. Prostate Cancer Stem Cells: Research Advances.

    PubMed

    Jaworska, Dagmara; Król, Wojciech; Szliszka, Ewelina

    2015-01-01

    Cancer stem cells have been defined as cells within a tumor that possesses the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor. Experimental evidence showed that these highly tumorigenic cells might be responsible for initiation and progression of cancer into invasive and metastatic disease. Eradicating prostate cancer stem cells, the root of the problem, has been considered as a promising target in prostate cancer treatment to improve the prognosis for patients with advanced stages of the disease.

  14. Research Methods: The First Class.

    ERIC Educational Resources Information Center

    Leming, Michael R.

    1979-01-01

    Describes a research methods course which fosters cooperation between students and gives them a positive experience with course content. Students are encouraged to view the sociologist more like a detective than a laboratory scientist. This reduces anxiety for students who fear the quantitative and empirical perspectives of the sciences.…

  15. Questionable Methods in Alcoholism Research.

    ERIC Educational Resources Information Center

    Koocher, Gerald P.

    1991-01-01

    Alcoholism research paradigms that use substantial cash incentives to attract participants and that call for alcoholics to consume ethanol in laboratory raise ethical questions. When using such methods, investigators should be obligated to discuss risk-benefit rationales and detail precautionary behaviors to protect participants. Discussion of…

  16. Symposium on research advances in clinical PET. Final performance report

    SciTech Connect

    J. Michael McGehee

    1992-01-01

    The Institute for Clinical PET and the U.S. Department of Energy (DOE) co-sponsored a symposium entitled 'Research in PET: International and Institutional Perspectives' that highlighted the activities of many leading investigators in the U.S. and throughout the world. Research programs at the DOE were discussed as were potential directions of PET research. International as well as institutional perspectives on PET research were presented. This symposium was successful in reaching those interested in research advances of clinical PET.

  17. Research investigations in oil shale, tar sand, coal research, advanced exploratory process technology, and advanced fuels research: Volume 1 -- Base program. Final report, October 1986--September 1993

    SciTech Connect

    Smith, V.E.

    1994-05-01

    Numerous studies have been conducted in five principal areas: oil shale, tar sand, underground coal gasification, advanced process technology, and advanced fuels research. In subsequent years, underground coal gasification was broadened to be coal research, under which several research activities were conducted that related to coal processing. The most significant change occurred in 1989 when the agreement was redefined as a Base Program and a Jointly Sponsored Research Program (JSRP). Investigations were conducted under the Base Program to determine the physical and chemical properties of materials suitable for conversion to liquid and gaseous fuels, to test and evaluate processes and innovative concepts for such conversions, to monitor and determine environmental impacts related to development of commercial-sized operations, and to evaluate methods for mitigation of potential environmental impacts. This report is divided into two volumes: Volume 1 consists of 28 summaries that describe the principal research efforts conducted under the Base Program in five topic areas. Volume 2 describes tasks performed within the JSRP. Research conducted under this agreement has resulted in technology transfer of a variety of energy-related research information. A listing of related publications and presentations is given at the end of each research topic summary. More specific and detailed information is provided in the topical reports referenced in the related publications listings.

  18. Advanced energy systems and technologies research programme

    NASA Astrophysics Data System (ADS)

    Lund, P.; Tuominen, E.

    NEMO 2 is a national energy research program for the evaluation, development and promotion of new and renewable forms of energy. NEMO 2 is one of the energy research programs of the Finnish Ministry of Trade and Industry for the years 1993-1998. In NEMO 2 -program, new energy technology is developed as a whole in close collaboration between industry, universities and research institutes, as well as with customers and consumers. The overall budget of NEMO 2 is close to 125 MFIM (1 dollar = 5.7 FIM, Nov. 1993). The main emphasis of the program is on wind and solar energy.

  19. Preface: Special Topic Section on Advanced Electronic Structure Methods for Solids and Surfaces

    SciTech Connect

    Michaelides, Angelos; Martinez, Todd J.; Alavi, Ali; Kresse, Georg

    2015-09-14

    This Special Topic section on Advanced Electronic Structure Methods for Solids and Surfaces contains a collection of research papers that showcase recent advances in the high accuracy prediction of materials and surface properties. It provides a timely snapshot of a growing field that is of broad importance to chemistry, physics, and materials science.

  20. NIAAA: Advancing Alcohol Research for 40 Years

    PubMed Central

    Warren, Kenneth R.; Hewitt, Brenda G.

    2010-01-01

    The National Institute on Alcohol Abuse and Alcoholism (NIAAA) has been the lead Federal agency responsible for scientific research on alcohol and its effects for 40 years. During that time, NIAAA has conducted and funded groundbreaking research, distilled and disseminated those research findings to a broad audience, and ultimately improved public health. Among NIAAA’s many significant contributions are the National Epidemiologic Survey on Alcohol and Related Conditions, the largest survey ever conducted on alcohol and associated psychiatric and medical conditions; investment in research to identify the genes underlying vulnerability to alcoholism; creation of the Collaborative Studies on Genetics of Alcoholism, a study of the genetics of alcoholism in a human population; leadership in exploring the effects of alcohol on fetal development and on a variety of diseases and organ systems; fostering alcoholism treatment, including supporting a medications development program that has funded more than 30 Phase 2 trials and 15 human laboratory studies; international collaborations and work across the National Institutes of Health; influential research on preventing alcohol problems through community programs as well as policy changes; and the translation of research findings to everyday practice, including the production of award-winning clinician training materials. PMID:23579932

  1. Advances in targeted proteomics and applications to biomedical research

    PubMed Central

    Shi, Tujin; Song, Ehwang; Nie, Song; Rodland, Karin D.; Liu, Tao; Qian, Wei-Jun; Smith, Richard D.

    2016-01-01

    Targeted proteomics technique has emerged as a powerful protein quantification tool in systems biology, biomedical research, and increasing for clinical applications. The most widely used targeted proteomics approach, selected reaction monitoring (SRM), also known as multiple reaction monitoring (MRM), can be used for quantification of cellular signaling networks and preclinical verification of candidate protein biomarkers. As an extension to our previous review on advances in SRM sensitivity herein we review recent advances in the method and technology for further enhancing SRM sensitivity (from 2012 to present), and highlighting its broad biomedical applications in human bodily fluids, tissue and cell lines. Furthermore, we also review two recently introduced targeted proteomics approaches, parallel reaction monitoring (PRM) and data-independent acquisition (DIA) with targeted data extraction on fast scanning high-resolution accurate-mass (HR/AM) instruments. Such HR/AM targeted quantification with monitoring all target product ions addresses SRM limitations effectively in specificity and multiplexing; whereas when compared to SRM, PRM and DIA are still in the infancy with a limited number of applications. Thus, for HR/AM targeted quantification we focus our discussion on method development, data processing and analysis, and its advantages and limitations in targeted proteomics. Finally, general perspectives on the potential of achieving both high sensitivity and high sample throughput for large-scale quantification of hundreds of target proteins are discussed. PMID:27302376

  2. Advances in targeted proteomics and applications to biomedical research.

    PubMed

    Shi, Tujin; Song, Ehwang; Nie, Song; Rodland, Karin D; Liu, Tao; Qian, Wei-Jun; Smith, Richard D

    2016-08-01

    Targeted proteomics technique has emerged as a powerful protein quantification tool in systems biology, biomedical research, and increasing for clinical applications. The most widely used targeted proteomics approach, selected reaction monitoring (SRM), also known as multiple reaction monitoring (MRM), can be used for quantification of cellular signaling networks and preclinical verification of candidate protein biomarkers. As an extension to our previous review on advances in SRM sensitivity (Shi et al., Proteomics, 12, 1074-1092, 2012) herein we review recent advances in the method and technology for further enhancing SRM sensitivity (from 2012 to present), and highlighting its broad biomedical applications in human bodily fluids, tissue and cell lines. Furthermore, we also review two recently introduced targeted proteomics approaches, parallel reaction monitoring (PRM) and data-independent acquisition (DIA) with targeted data extraction on fast scanning high-resolution accurate-mass (HR/AM) instruments. Such HR/AM targeted quantification with monitoring all target product ions addresses SRM limitations effectively in specificity and multiplexing; whereas when compared to SRM, PRM and DIA are still in the infancy with a limited number of applications. Thus, for HR/AM targeted quantification we focus our discussion on method development, data processing and analysis, and its advantages and limitations in targeted proteomics. Finally, general perspectives on the potential of achieving both high sensitivity and high sample throughput for large-scale quantification of hundreds of target proteins are discussed.

  3. Advances in Methods for Assessing Longitudinal Change

    ERIC Educational Resources Information Center

    Grimm, Kevin J.; Mazza, Gina L.; Mazzocco, Michèle M. M.

    2016-01-01

    Educational research aims to understand how and why students change over time. With its emphasis on within-person change, latent change score models provide educational researchers with a more general and flexible framework for testing nuanced hypotheses regarding within-person change and between-person differences in within-person change. Models…

  4. Recent advances in computational structural reliability analysis methods

    NASA Technical Reports Server (NTRS)

    Thacker, Ben H.; Wu, Y.-T.; Millwater, Harry R.; Torng, Tony Y.; Riha, David S.

    1993-01-01

    The goal of structural reliability analysis is to determine the probability that the structure will adequately perform its intended function when operating under the given environmental conditions. Thus, the notion of reliability admits the possibility of failure. Given the fact that many different modes of failure are usually possible, achievement of this goal is a formidable task, especially for large, complex structural systems. The traditional (deterministic) design methodology attempts to assure reliability by the application of safety factors and conservative assumptions. However, the safety factor approach lacks a quantitative basis in that the level of reliability is never known and usually results in overly conservative designs because of compounding conservatisms. Furthermore, problem parameters that control the reliability are not identified, nor their importance evaluated. A summary of recent advances in computational structural reliability assessment is presented. A significant level of activity in the research and development community was seen recently, much of which was directed towards the prediction of failure probabilities for single mode failures. The focus is to present some early results and demonstrations of advanced reliability methods applied to structural system problems. This includes structures that can fail as a result of multiple component failures (e.g., a redundant truss), or structural components that may fail due to multiple interacting failure modes (e.g., excessive deflection, resonate vibration, or creep rupture). From these results, some observations and recommendations are made with regard to future research needs.

  5. Educating Scientifically - Advances in Physics Education Research

    SciTech Connect

    Finkelstein, Noah

    2007-05-16

    It is now fairly well documented that traditionally taught, large-scale introductory physics courses fail to teach our students the basics. In fact, often these same courses have been found to teach students things we do not want. Building on a tradition of research in physics, the physics education research community has been researching the effects of educational practice and reforms at the undergraduate level for many decades. From these efforts and those within the fields of education, cognitive science, and psychology we have learned a great deal about student learning and environments that support learning for an increasingly diverse population of students in the physics classroom. This talk will introduce some of the ideas from physics education research, discuss a variety of effective classroom practices/ surrounding educational structures, and begin to examine why these do (and do not) work. I will present both a survey of physics education research and some of the exciting theoretical and experimental developments emerging from the University of Colorado.

  6. Educating Scientifically: Advances in Physics Education Research

    SciTech Connect

    Finkelstein, Noah

    2007-05-16

    It is now fairly well documented that traditionally taught, large-scale introductory physics courses fail to teach our students the basics. In fact, often these same courses have been found to teach students things we do not want. Building on a tradition of research in physics, the physics education research community has been researching the effects of educational practice and reforms at the undergraduate level for many decades. From these efforts and those within the fields of education, cognitive science, and psychology we have learned a great deal about student learning and environments that support learning for an increasingly diverse population of students in the physics classroom. This talk will introduce some of the ideas from physics education research, discuss a variety of effective classroom practices/ surrounding educational structures, and begin to examine why these do (and do not) work. I will present both a survey of physics education research and some of the exciting theoretical and experimental developments emerging from the University of Colorado.

  7. Educating Scientifically - Advances in Physics Education Research

    ScienceCinema

    Finkelstein, Noah [University of Colorado, Colorado, USA

    2016-07-12

    It is now fairly well documented that traditionally taught, large-scale introductory physics courses fail to teach our students the basics. In fact, often these same courses have been found to teach students things we do not want. Building on a tradition of research in physics, the physics education research community has been researching the effects of educational practice and reforms at the undergraduate level for many decades. From these efforts and those within the fields of education, cognitive science, and psychology we have learned a great deal about student learning and environments that support learning for an increasingly diverse population of students in the physics classroom. This talk will introduce some of the ideas from physics education research, discuss a variety of effective classroom practices/ surrounding educational structures, and begin to examine why these do (and do not) work. I will present both a survey of physics education research and some of the exciting theoretical and experimental developments emerging from the University of Colorado.

  8. INEEL Advanced Radiotherapy Research Program Annual Report 2001

    SciTech Connect

    Venhuizen, James R.

    2002-04-30

    This report summarizes the major activities and accomplishments of the Idaho National Engineering and Environmental Laboratory (INEEL) Advanced Radiotherapy Research Program for calendar year 2001. Applications of supportive research and development, as well as technology deployment in the fields of chemistry, radiation physics and dosimetry, and neutron source design and demonstration are described. Contributions in the fields of physics and biophysics include development of advanced patient treatment planning software, feasibility studies of accelerator neutron source technology for Neutron Capture Therapy (NCT), and completion of major modifications to the research reactor at Washington State University to produce an epithermal-neutron beam for NCT research applications.

  9. INEEL Advanced Radiotherapy Research Program Annual Report 2001

    SciTech Connect

    Venhuizen, James Robert

    2002-04-01

    This report summarizes the major activities and accomplishments of the Idaho National Engineering and Environmental Laboratory (INEEL) Advanced Radiotherapy Research Program for calendar year 2001. Applications of supportive research and development, as well as technology deployment in the fields of chemistry, radiation physics and dosimetry, and neutron source design and demonstration are described. Contributions in the fields of physics and biophysics include development of advanced patient treatment planning software, feasibility studies of accelerator neutron source technology for Neutron Capture Therapy (NCT), and completion of major modifications to the research reactor at Washington State University to produce an epithermal-neutron beam for NCT research applications.

  10. Advanced electrochemical methods for characterizing the performance of organic coatings

    NASA Astrophysics Data System (ADS)

    Upadhyay, Vinod

    Advanced electrochemical techniques such as electrochemical impedance spectroscopy (EIS), electrochemical noise method (ENM) and coulometry as tools to study and extract information about the coating system is the focus of this thesis. This thesis explored three areas of research. In all the three research areas, advanced electrochemical techniques were used to extract information and understand the coating system. The first area was to use EIS and coulometric technique for extracting information using AC-DC-AC method. It was examined whether the total charge passing through the coating during the DC polarization step of AC-DC-AC determines coating failure. An almost constant total amount of charge transfer was required by the coating before it failed and was independent of the applied DC polarization. The second area focused in this thesis was to investigate if embedded sensors in coatings are sensitive enough to monitor changes in environmental conditions and to locate defects in coatings by electrochemical means. Influence of topcoat on embedded sensor performance was also studied. It was observed that the embedded sensors can distinguish varying environmental conditions and locate defects in coatings. Topcoat could influence measurements made using embedded sensors and the choice of topcoat could be very important in the successful use of embedded sensors. The third area of research of this thesis work was to examine systematically polymer-structure coating property relationships using electrochemical impedance spectroscopy. It was observed that the polymer modifications could alter the electrochemical properties of the coating films. Moreover, it was also observed that by cyclic wet-dry capacitance measurement using aqueous electrolyte and ionic liquid, ranking of the stability of organic polymer films could be performed.

  11. Recent advances in Tourette syndrome research.

    PubMed

    Albin, Roger L; Mink, Jonathan W

    2006-03-01

    Tourette syndrome (TS) is a developmentally regulated neurobehavioral disorder characterized by involuntary, stereotyped, repetitive movements. Recent anatomical and neuroimaging studies have provided evidence for abnormal basal ganglia and dopaminergic function in TS. Basic research on striatal inhibitory mechanisms and dopaminergic function complements the recent neuroimaging and anatomical data. Parallel studies of basal ganglia participation in the normal performance and learning of stereotyped repetitive behaviors or habits has provided additional insight. These lines of research have provided new pieces to the TS puzzle, and their increasing convergence is showing how those pieces can be put together.

  12. Advanced energy projects; FY 1995 research summaries

    SciTech Connect

    1995-09-01

    The AEP Division supports projects to explore novel energy-related concepts which are typically at an early stage of scientific development, and high-risk, exploratory concepts. Topical areas presently receiving support are: novel materials for energy technology, renewable and biodegradable materials, exploring uses of new scientific discoveries, alternate pathways to energy efficiency, alternative energy sources, and innovative approaches to waste treatment and reduction. There were 46 research projects during FY 1995; ten were initiated during that fiscal year. The summaries are separated into grant and laboratory programs, and small business innovation research programs.

  13. Load research manual. Volume 3. Load research for advanced technologies

    SciTech Connect

    Brandenburg, L.; Clarkson, G.; Grund, Jr., C.; Leo, J.; Asbury, J.; Brandon-Brown, F.; Derderian, H.; Mueller, R.; Swaroop, R.

    1980-11-01

    This three-volume manual presents technical guidelines for electric utility load research. Special attention is given to issues raised by the load data reporting requirements of the Public Utility Regulatory Policies Act of 1978 and to problems faced by smaller utilities that are initiating load research programs. The manual includes guides to load research literature and glossaries of load research and statistical terms. In Volume 3, special load research procedures are presented for solar, wind, and cogeneration technologies.

  14. Advanced quantitative measurement methodology in physics education research

    NASA Astrophysics Data System (ADS)

    Wang, Jing

    The ultimate goal of physics education research (PER) is to develop a theoretical framework to understand and improve the learning process. In this journey of discovery, assessment serves as our headlamp and alpenstock. It sometimes detects signals in student mental structures, and sometimes presents the difference between expert understanding and novice understanding. Quantitative assessment is an important area in PER. Developing research-based effective assessment instruments and making meaningful inferences based on these instruments have always been important goals of the PER community. Quantitative studies are often conducted to provide bases for test development and result interpretation. Statistics are frequently used in quantitative studies. The selection of statistical methods and interpretation of the results obtained by these methods shall be connected to the education background. In this connecting process, the issues of educational models are often raised. Many widely used statistical methods do not make assumptions on the mental structure of subjects, nor do they provide explanations tailored to the educational audience. There are also other methods that consider the mental structure and are tailored to provide strong connections between statistics and education. These methods often involve model assumption and parameter estimation, and are complicated mathematically. The dissertation provides a practical view of some advanced quantitative assessment methods. The common feature of these methods is that they all make educational/psychological model assumptions beyond the minimum mathematical model. The purpose of the study is to provide a comparison between these advanced methods and the pure mathematical methods. The comparison is based on the performance of the two types of methods under physics education settings. In particular, the comparison uses both physics content assessments and scientific ability assessments. The dissertation includes three

  15. Advances in Bayesian Modeling in Educational Research

    ERIC Educational Resources Information Center

    Levy, Roy

    2016-01-01

    In this article, I provide a conceptually oriented overview of Bayesian approaches to statistical inference and contrast them with frequentist approaches that currently dominate conventional practice in educational research. The features and advantages of Bayesian approaches are illustrated with examples spanning several statistical modeling…

  16. Advances in Music-Reading Research

    ERIC Educational Resources Information Center

    Gudmundsdottir, Helga Rut

    2010-01-01

    The purpose of this paper is to construct a comprehensive review of the research literature in the reading of western staff notation. Studies in music perception, music cognition, music education and music neurology are cited. The aim is to establish current knowledge in music-reading acquisition and what is needed for further progress in this…

  17. Advances in Child Development: Theory and Research.

    ERIC Educational Resources Information Center

    Nesdale, Andrew R., Ed.; And Others

    This book consists of 31 papers focusing on aspects of child development. Mainly reports of research, papers are grouped topically into four sections dealing respectively with perceptual, language/communication, cognitive, and social development. Most of the nine papers in section 1 focus on the perceptual development of infants. Topics include…

  18. Advancing Research on the Community College

    ERIC Educational Resources Information Center

    Bers, Trudy H.

    2007-01-01

    Arthur M. Cohen and his colleagues at the Center for the Study of Community Colleges have made significant and broad contributions to the scholarly literature and empirical research about community colleges. Although Cohen's interests are comprehensive and his writings touch on multiple issues associated with community colleges, his empirical work…

  19. Advanced Energy Projects: FY 1993, Research summaries

    SciTech Connect

    Not Available

    1993-09-01

    AEP has been supporting research on novel materials for energy technology, renewable and biodegradable materials, new uses for scientific discoveries, alternate pathways to energy efficiency, alternative energy sources, innovative approaches to waste treatment and reduction, etc. The summaries are grouped according to projects active in FY 1993, Phase I SBIR projects, and Phase II SBIR projects. Investigator and institutional indexes are included.

  20. Advanced AE Techniques in Composite Materials Research

    NASA Technical Reports Server (NTRS)

    Prosser, William H.

    1996-01-01

    Advanced, waveform based acoustic emission (AE) techniques have been successfully used to evaluate damage mechanisms in laboratory testing of composite coupons. An example is presented in which the initiation of transverse matrix cracking was monitored. In these tests, broad band, high fidelity acoustic sensors were used to detect signals which were then digitized and stored for analysis. Analysis techniques were based on plate mode wave propagation characteristics. This approach, more recently referred to as Modal AE, provides an enhanced capability to discriminate and eliminate noise signals from those generated by damage mechanisms. This technique also allows much more precise source location than conventional, threshold crossing arrival time determination techniques. To apply Modal AE concepts to the interpretation of AE on larger composite specimens or structures, the effects of modal wave propagation over larger distances and through structural complexities must be well characterized and understood. To demonstrate these effects, measurements of the far field, peak amplitude attenuation of the extensional and flexural plate mode components of broad band simulated AE signals in large composite panels are discussed. These measurements demonstrated that the flexural mode attenuation is dominated by dispersion effects. Thus, it is significantly affected by the thickness of the composite plate. Furthermore, the flexural mode attenuation can be significantly larger than that of the extensional mode even though its peak amplitude consists of much lower frequency components.

  1. Microfluidic Devices in Advanced Caenorhabditis elegans Research.

    PubMed

    Muthaiyan Shanmugam, Muniesh; Subhra Santra, Tuhin

    2016-01-01

    The study of model organisms is very important in view of their potential for application to human therapeutic uses. One such model organism is the nematode worm, Caenorhabditis elegans. As a nematode, C. elegans have ~65% similarity with human disease genes and, therefore, studies on C. elegans can be translated to human, as well as, C. elegans can be used in the study of different types of parasitic worms that infect other living organisms. In the past decade, many efforts have been undertaken to establish interdisciplinary research collaborations between biologists, physicists and engineers in order to develop microfluidic devices to study the biology of C. elegans. Microfluidic devices with the power to manipulate and detect bio-samples, regents or biomolecules in micro-scale environments can well fulfill the requirement to handle worms under proper laboratory conditions, thereby significantly increasing research productivity and knowledge. The recent development of different kinds of microfluidic devices with ultra-high throughput platforms has enabled researchers to carry out worm population studies. Microfluidic devices primarily comprises of chambers, channels and valves, wherein worms can be cultured, immobilized, imaged, etc. Microfluidic devices have been adapted to study various worm behaviors, including that deepen our understanding of neuromuscular connectivity and functions. This review will provide a clear account of the vital involvement of microfluidic devices in worm biology. PMID:27490525

  2. PREFACE: 6th EEIGM International Conference on Advanced Materials Research

    NASA Astrophysics Data System (ADS)

    Horwat, David; Ayadi, Zoubir; Jamart, Brigitte

    2012-02-01

    The 6th EEIGM Conference on Advanced Materials Research (AMR 2011) was held at the European School of Materials Engineering (EEIGM) on the 7-8 November 2011 in Nancy, France. This biennial conference organized by the EEIGM is a wonderful opportunity for all scientists involved in the EEIGM programme, in the 'Erasmus Mundus' Advanced Materials Science and Engineering Master programme (AMASE) and the 'Erasmus Mundus' Doctoral Programme in Materials Science and Engineering (DocMASE), to present their research in the various fields of Materials Science and Engineering. This conference is also open to other universities who have strong links with the EEIGM and provides a forum for the exchange of ideas, co-operation and future orientations by means of regular presentations, posters and a round-table discussion. This edition of the conference included a round-table discussion on composite materials within the Interreg IVA project '+Composite'. Following the publication of the proceedings of AMR 2009 in Volume 5 of this journal, it is with great pleasure that we present this selection of articles to the readers of IOP Conference Series: Materials Science and Engineering. Once again it represents the interdisciplinary nature of Materials Science and Engineering, covering basic and applicative research on organic and composite materials, metallic materials and ceramics, and characterization methods. The editors are indebted to all the reviewers for reviewing the papers at very short notice. Special thanks are offered to the sponsors of the conference including EEIGM-Université de Lorraine, AMASE, DocMASE, Grand Nancy, Ville de Nancy, Region Lorraine, Fédération Jacques Villermaux, Conseil Général de Meurthe et Moselle, Casden and '+Composite'. Zoubir Ayadi, David Horwat and Brigitte Jamart

  3. Advancing translational research with the Semantic Web

    PubMed Central

    Ruttenberg, Alan; Clark, Tim; Bug, William; Samwald, Matthias; Bodenreider, Olivier; Chen, Helen; Doherty, Donald; Forsberg, Kerstin; Gao, Yong; Kashyap, Vipul; Kinoshita, June; Luciano, Joanne; Marshall, M Scott; Ogbuji, Chimezie; Rees, Jonathan; Stephens, Susie; Wong, Gwendolyn T; Wu, Elizabeth; Zaccagnini, Davide; Hongsermeier, Tonya; Neumann, Eric; Herman, Ivan; Cheung, Kei-Hoi

    2007-01-01

    Background A fundamental goal of the U.S. National Institute of Health (NIH) "Roadmap" is to strengthen Translational Research, defined as the movement of discoveries in basic research to application at the clinical level. A significant barrier to translational research is the lack of uniformly structured data across related biomedical domains. The Semantic Web is an extension of the current Web that enables navigation and meaningful use of digital resources by automatic processes. It is based on common formats that support aggregation and integration of data drawn from diverse sources. A variety of technologies have been built on this foundation that, together, support identifying, representing, and reasoning across a wide range of biomedical data. The Semantic Web Health Care and Life Sciences Interest Group (HCLSIG), set up within the framework of the World Wide Web Consortium, was launched to explore the application of these technologies in a variety of areas. Subgroups focus on making biomedical data available in RDF, working with biomedical ontologies, prototyping clinical decision support systems, working on drug safety and efficacy communication, and supporting disease researchers navigating and annotating the large amount of potentially relevant literature. Results We present a scenario that shows the value of the information environment the Semantic Web can support for aiding neuroscience researchers. We then report on several projects by members of the HCLSIG, in the process illustrating the range of Semantic Web technologies that have applications in areas of biomedicine. Conclusion Semantic Web technologies present both promise and challenges. Current tools and standards are already adequate to implement components of the bench-to-bedside vision. On the other hand, these technologies are young. Gaps in standards and implementations still exist and adoption is limited by typical problems with early technology, such as the need for a critical mass of

  4. Advanced particulate matter control apparatus and methods

    DOEpatents

    Miller, Stanley J.; Zhuang, Ye; Almlie, Jay C.

    2012-01-10

    Apparatus and methods for collection and removal of particulate matter, including fine particulate matter, from a gas stream, comprising a unique combination of high collection efficiency and ultralow pressure drop across the filter. The apparatus and method utilize simultaneous electrostatic precipitation and membrane filtration of a particular pore size, wherein electrostatic collection and filtration occur on the same surface.

  5. Oil shale, tar sand, coal research, advanced exploratory process technology, jointly sponsored research

    SciTech Connect

    Not Available

    1992-01-01

    Progress made in five research programs is described. The subtasks in oil shale study include oil shale process studies and unconventional applications and markets for western oil shale.The tar sand study is on recycle oil pyrolysis and extraction (ROPE) process. Four tasks are described in coal research: underground coal gasification; coal combustion; integrated coal processing concepts; and sold waste management. Advanced exploratory process technology includes: advanced process concepts; advanced mitigation concepts; and oil and gas technology. Jointly sponsored research covers: organic and inorganic hazardous waste stabilization; CROW field demonstration with Bell Lumber and Pole; development and validation of a standard test method for sequential batch extraction fluid; PGI demonstration project; operation and evaluation of the CO[sub 2] HUFF-N-PUFF process; fly ash binder for unsurfaced road aggregates; solid state NMR analysis of Mesaverde group, Greater Green River Basin, tight gas sands; flow-loop testing of double-wall pipe for thermal applications; shallow oil production using horizontal wells with enhanced oil recovery techniques; NMR analysis of sample from the ocean drilling program; and menu driven access to the WDEQ hydrologic data management system.

  6. Development of advanced acreage estimation methods

    NASA Technical Reports Server (NTRS)

    Guseman, L. F., Jr. (Principal Investigator)

    1982-01-01

    The development of an accurate and efficient algorithm for analyzing the structure of MSS data, the application of the Akaiki information criterion to mixture models, and a research plan to delineate some of the technical issues and associated tasks in the area of rice scene radiation characterization are discussed. The AMOEBA clustering algorithm is refined and documented.

  7. Advanced ASON prototyping research activities in China

    NASA Astrophysics Data System (ADS)

    Hu, WeiSheng; Jin, Yaohui; Guo, Wei; Su, Yikai; He, Hao; Sun, Weiqiang

    2005-02-01

    This paper provides an overview of prototyping research activities of automatically switched optical networks and transport networks (ASONs/ASTNs) in China. In recent years, China has recognized the importance and benefits of the emerging ASON/ASTN techniques. During the period of 2001 and 2002, the national 863 Program of China started the preliminary ASON research projects with the main objectives to build preliminary ASON testbeds, develop control plane protocols and test their performance in the testbeds. During the period of 2003 and 2004, the 863 program started ASTN prototyping equipment projects for more practical applications. Totally 12 ASTN equipments are being developed by three groups led by Chinese venders: ZTE with Beijing University of Posts and Telecommunications (BUPT), Wuhan Research Institute of Posts and Telecommunication (WRI) with Shanghai Jiao Tong University (SJTU), and Huawei Inc. Meanwhile, as the ASTN is maturing, some of the China"s carries are participating in the OIF"s World Interoperability Demonstration, carrying out ASTN test, or deploying ASTN backbone networks. Finally, several ASTN backbone networks being tested or deployed now will be operated by the carries in 2005. The 863 Program will carry out an ASTN field trail in Yangtse River Delta, and finally deploy the 3TNET. 3TNET stands for Tbps transmission, Tbps switching, and Tbps routing, as well as a network integrating the above techniques. A task force under the "863" program is responsible for ASTN equipment specifications and interoperation agreements, technical coordination among all the participants, schedule of the whole project during the project undergoing, and organization of internetworking of all the equipments in the laboratories and field trials.

  8. Advanced research in instrumentation and diagnostics technology

    SciTech Connect

    Sheen, S.H.; Lawrence, W.P.; Raptis, A.C.

    1992-09-01

    this research project will develop an ultrasonic flow imaging system based on tomographic technique. Initially, we will demonstrate both the reflection and diffraction tomographic applied to flow imaging. Then, the direct inversion problem will be examined. In this paper, we present the initial assessment of the feasibility and the evaluation of practical wedge designs. Major tasks of the project include (1) a feasibility study, (2) evaluation of sensing geometry and wedge design, (3) development of image reconstruction algorithm, and (4) flow tests of the imaging system. At present, we have completed the feasibility study and are in the process of evaluating wedge design.

  9. ADVANCING FINE ROOT RESEARCH WITH MINIRHIZOTRONS

    EPA Science Inventory

    Minirhizotrons provide a nondestructive, in situ method for directly viewing and studying fine roots. Although many insights into fine roots have been gained using minirhizotrons, it is clear from the literature that there is still wide variation in how minirhizotrons and minirhi...

  10. The biology of infertility: research advances and clinical challenges

    PubMed Central

    Matzuk, Martin M; Lamb, Dolores J

    2013-01-01

    Reproduction is required for the survival of all mammalian species, and thousands of essential ‘sex’ genes are conserved through evolution. Basic research helps to define these genes and the mechanisms responsible for the development, function and regulation of the male and female reproductive systems. However, many infertile couples continue to be labeled with the diagnosis of idiopathic infertility or given descriptive diagnoses that do not provide a cause for their defect. For other individuals with a known etiology, effective cures are lacking, although their infertility is often bypassed with assisted reproductive technologies (ART), some accompanied by safety or ethical concerns. Certainly, progress in the field of reproduction has been realized in the twenty-first century with advances in the understanding of the regulation of fertility, with the production of over 400 mutant mouse models with a reproductive phenotype and with the promise of regenerative gonadal stem cells. Indeed, the past six years have witnessed a virtual explosion in the identification of gene mutations or polymorphisms that cause or are linked to human infertility. Translation of these findings to the clinic remains slow, however, as do new methods to diagnose and treat infertile couples. Additionally, new approaches to contraception remain elusive. Nevertheless, the basic and clinical advances in the understanding of the molecular controls of reproduction are impressive and will ultimately improve patient care. PMID:18989307

  11. Major clinical research advances in gynecologic cancer in 2014.

    PubMed

    Suh, Dong Hoon; Lee, Kyung Hun; Kim, Kidong; Kang, Sokbom; Kim, Jae Weon

    2015-04-01

    In 2014, 9 topics were selected as major advances in clinical research for gynecologic oncology: 2 each in cervical and corpus cancer, 4 in ovarian cancer, and 1 in breast cancer. For cervical cancer, several therapeutic agents showed viable antitumor clinical response in recurrent and metastatic disease: bevacizumab, cediranib, and immunotherapies including human papillomavirus (HPV)-tumor infiltrating lymphocytes and Z-100. The HPV test received FDA approval as the primary screening tool of cervical cancer in women aged 25 and older, based on the results of the ATHENA trial, which suggested that the HPV test was a more sensitive and efficient strategy for cervical cancer screening than methods based solely on cytology. For corpus cancers, results of a phase III Gynecologic Oncology Group (GOG) 249 study of early-stage endometrial cancer with high-intermediate risk factors are followed by the controversial topic of uterine power morcellation in minimally invasive gynecologic surgery. Promising results of phase II studies regarding the effectiveness of olaparib in various ovarian cancer settings are summarized. After a brief review of results from a phase III study on pazopanib maintenance therapy in advanced ovarian cancer, 2 outstanding 2014 ASCO presentations cover the topic of using molecular subtypes in predicting response to bevacizumab. A review of the use of opportunistic bilateral salpingectomy as an ovarian cancer preventive strategy in the general population is presented. Two remarkable studies that discussed the effectiveness of adjuvant ovarian suppression in premenopausal early breast cancer have been selected as the last topics covered in this review.

  12. Students in Advanced Research for Sky Surveillance

    NASA Astrophysics Data System (ADS)

    Gehrels, Tom

    1997-11-01

    Spacewatch program discovers small bodies (asteroids and comets) in the solar system and analyzes their distributions with orbital parameters and absolute magnitude. Scanning of the night sky is conducted 18-20 nights per month with tbe 0.9-m Spacewatch Telescope on Kitt Peak. About 1200. to 2000 sqare degrees of sky are searched each year to a V magnitude level of 21.3. Spacewatch discoveries support studies of the evolution of the Centaur, Trojan, Main-Belt, and Earth-approaching asteroid populations. Space watch also finds potential targets for space missions, finds objects that might present a hazard of impact on the Earth, provides accurate astrometry of about 30,000 asteroids annually, and recovers comets and asteroids that are too faint for most other observers. This AASERT grant supported several undergraduate students working on upgrades to instrumentation and analyses of date under the supervision of spacewatch engineers and researchers. The opportunity to have young, energetic new members of the group accomplished a great del of work, simulated and exxelerated our research efforts, and enhanced the students' career opportunities.

  13. Geneticization and bioethics: advancing debate and research.

    PubMed

    Arnason, Vilhjálmur; Hjörleifsson, Stefán

    2007-12-01

    In the present paper, we focus on the role that the concept of geneticization has played in the discussion about health care, bioethics and society. The concept is discussed and examples from the evolving discourse about geneticization are critically analyzed. The relationship between geneticization, medicalization and biomedicalization is described, emphasizing how debates about the latter concepts can inspire future research on geneticization. It is shown how recurrent themes from the media coverage of genetics portray typical traits of geneticization and thus contribute to the process. We look at examples of small-scale studies from the literature where geneticization of medical practice has been demonstrated. Methodological disputes about the relevance of empirical evidence for the geneticization thesis and the normative status of the concept are discussed. We consider arguments to the effect that ideas from mainstream bioethics have facilitated geneticization by emphasizing individualistic notions of autonomy and responsibility while ignoring the role of genetics in the wider social context. It is shown how a concept like geneticization, which can be used to draw the attention of philosophers, social scientists and others to challenges that tend to be neglected by mainstream bioethics, also has the potential to move people's attention away from other pertinent issues. This may happen if researchers become preoccupied with the transformative effects of genetics, and we argue that a wider reading of geneticization should inspire critical analysis of the sociocultural preconditions under which genetics is currently evolving. PMID:17705026

  14. Materials and light thermal structures research for advanced space exploration

    NASA Technical Reports Server (NTRS)

    Thornton, Earl A.; Starke, Edgar A., Jr.; Herakovich, Carl T.

    1991-01-01

    The Light Thermal Structures Center at the University of Virginia sponsors educational and research programs focused on the development of reliable, lightweight structures to function in hostile thermal environments. Technology advances in materials and design methodology for light thermal structures will contribute to improved space vehicle design concepts with attendant weight savings. This paper highlights current research activities in three areas relevant to space exploration: low density, high temperature aluminum alloys, composite materials, and structures with thermal gradients. Advances in the development of new aluminum-lithium alloys and mechanically alloyed aluminum alloys are described. Material properties and design features of advanced composites are highlighted. Research studies in thermal structures with temperature gradients include inelastic panel buckling and thermally induced unstable oscillations. Current and future research is focused on the integration of new materials with applications to structural components with thermal gradients.

  15. Advanced spectral methods for climatic time series

    USGS Publications Warehouse

    Ghil, M.; Allen, M.R.; Dettinger, M.D.; Ide, K.; Kondrashov, D.; Mann, M.E.; Robertson, A.W.; Saunders, A.; Tian, Y.; Varadi, F.; Yiou, P.

    2002-01-01

    The analysis of univariate or multivariate time series provides crucial information to describe, understand, and predict climatic variability. The discovery and implementation of a number of novel methods for extracting useful information from time series has recently revitalized this classical field of study. Considerable progress has also been made in interpreting the information so obtained in terms of dynamical systems theory. In this review we describe the connections between time series analysis and nonlinear dynamics, discuss signal- to-noise enhancement, and present some of the novel methods for spectral analysis. The various steps, as well as the advantages and disadvantages of these methods, are illustrated by their application to an important climatic time series, the Southern Oscillation Index. This index captures major features of interannual climate variability and is used extensively in its prediction. Regional and global sea surface temperature data sets are used to illustrate multivariate spectral methods. Open questions and further prospects conclude the review.

  16. Advanced research and technology programs for advanced high-pressure oxygen-hydrogen rocket propulsion

    NASA Technical Reports Server (NTRS)

    Marsik, S. J.; Morea, S. F.

    1985-01-01

    A research and technology program for advanced high pressure, oxygen-hydrogen rocket propulsion technology is presently being pursued by the National Aeronautics and Space Administration (NASA) to establish the basic discipline technologies, develop the analytical tools, and establish the data base necessary for an orderly evolution of the staged combustion reusable rocket engine. The need for the program is based on the premise that the USA will depend on the Shuttle and its derivative versions as its principal Earth-to-orbit transportation system for the next 20 to 30 yr. The program is focused in three principal areas of enhancement: (1) life extension, (2) performance, and (3) operations and diagnosis. Within the technological disciplines the efforts include: rotordynamics, structural dynamics, fluid and gas dynamics, materials fatigue/fracture/life, turbomachinery fluid mechanics, ignition/combustion processes, manufacturing/producibility/nondestructive evaluation methods and materials development/evaluation. An overview of the Advanced High Pressure Oxygen-Hydrogen Rocket Propulsion Technology Program Structure and Working Groups objectives are presented with highlights of several significant achievements.

  17. Research on geothermal chemistry and advanced instrumentation

    NASA Astrophysics Data System (ADS)

    Robertus, R. J.; Shannon, D. W.; Sullivan, R. G.; Kindle, C. H.; Pool, K. H.

    1985-09-01

    Research at the Pacific Northwest Laboratory (PNL) focuses on long-term geothermal power plant reliability. Past work concentrated on development of continuous high-temperature probes for monitoring process variables. PNL also completed a comprehensive handbook of brine treatment processes as they relate to injection well longevity. A recently completed study analyzed corrosion in the hydrocarbon system of a binary cycle plant. Over the two-year monitoring period, corrosion rates were less than 1 MPY in any part of the hydrocarbon system. The system was kept completely dry so the rates seem reasonable. Present projects include: (1) determination of gas breakout conditions at the Herber Binary Demonstration Plant operated by San Diego Gas and Electric Company; (2) generation of water mixing solubility data; (3) installation of prototype leak detectors at the Herber Plant; and (4) evaluation of state-of-the-art particle counters.

  18. idaho Accelerator Center Advanced Fuel Cycle Research

    SciTech Connect

    Wells, Douglas; Dale, Dan

    2011-10-20

    The technical effort has been in two parts called; Materials Science and Instrumentation Development. The Materials Science technical program has been based on a series of research and development achievements in Positron-Annihilation Spectroscopy (PAS) for defect detection in structural materials. This work is of particular importance in nuclear power and its supporting systems as the work included detection of defects introduced by mechanical and thermal phenomena as well as those caused by irradiation damage. The second part of the program has focused on instrumentation development using active interrogation techniques supporting proliferation resistant recycling methodologies and nuclear material safeguards. This effort has also lead to basic physics studies of various phenomena relating to photo-fission. Highlights of accomplishments and facility improvement legacies in these areas over the program period include

  19. Advances in the CIS research at NREL

    SciTech Connect

    Ramanathan, K.; Bhattacharya, R.N.; Granata, J.; Webb, J.; Niles, D.; Contreras, M.A.; Wiesner, H.; Hasoon, F.S.; Noufi, R.

    1997-12-31

    This paper summarizes the research of the CIS Team at NREL in three major areas: absorber deposition; understanding the role of chemical bath deposited (CBD) CdS in CIS junctions; and in the development of devices without CdS. Low cost, scaleable processes chosen for absorber fabrication include sputtering, electrodeposition (ED), and close spaced sublimation (CSS). The interaction between the CBD and the CIS has been investigated and the results show that Cd might be instrumental in shaping the interface. The authors have also developed a process to fabricate a 13.5% efficiency ZnO/CuInGaSe{sub 2} device without CdS or other buffer layers.

  20. Advanced moisture sensor research and development

    SciTech Connect

    De Los Santos, A.

    1992-10-31

    During this period, testing of the system continued at the American Fructose (AF) plant in Dimmitt, Texas. Testing at the first two sites (dryer output and dryer input) was completed. Following the testing at the second site, the sensor was returned to the Southwest Research Institute (SwRI) laboratories for modifications and for fitting of the additional components required to allow sampling of the material to be measured at the third site. These modifications were completed during this reporting period, and the system is scheduled to be installed at the third site (Rotary Vacuum Filter output) early in the next period. Laboratory measurements of corn germ (to be measured at the fourth site) and a variety of fruits and vegetables (one of which will be measured at the fifth site) have also continued during this period.

  1. Advances in methods for deepwater TLP installations

    SciTech Connect

    Wybro, P.G.

    1995-10-01

    This paper describes a method suitable for installing deepwater TLP structures in water depths beyond 3,000 ft. An overview is presented of previous TLP installation, wherein an evaluation is made of the various methods and their suitability to deepwater applications. A novel method for installation of deepwater TLP`s is described. This method of installation is most suitable for deepwater and/or large TLP structures, but can also be used in moderate water depth as well. The tendon installation method utilizes the so-called Platform Arrestor Concept (PAC), wherein tendon sections are transported by barges to site, and assembled vertically using a dynamically position crane vessel. The tendons are transferred to the platform where they are hung off until there are a full complement of tendons. The hull lock off operation is performed on all tendons simultaneously, avoiding dangerous platform resonant behavior. The installation calls for relatively simple installation equipment, and also enables the use of simple tendon tie-off equipment, such as a single piece nut.

  2. Expert Meeting Report: Advanced Envelope Research for Factory Built Housing

    SciTech Connect

    Levy, E.; Mullens, M.; Tompos, E.; Kessler, B.; Rath, P.

    2012-04-01

    This report provides information about the Building America expert meeting on advanced envelope research for factory built housing, hosted by the ARIES Collaborative on October 11, 2011, in Phoenix, Arizona. The goals of this meeting were to provide a comprehensive solution to the use of three previously selected advanced alternatives for factory-built wall construction, assess each option focusing on major issues relating to viability and commercial potential, and determine additional steps are required to reach this potential.

  3. Expert Meeting Report: Advanced Envelope Research for Factory Built Housing

    SciTech Connect

    Levy, E.; Mullens, M.; Tompos, E.; Kessler, B.; Rath, P.

    2012-04-01

    This report provides information about the expert meeting on advanced envelope research for factory built housing, hosted by the ARIES Collaborative on October 11, 2011, in Phoenix, Arizona. The goals of this meeting were to provide a comprehensive solution to the use of three previously selected advanced alternatives for factory-built wall construction, assess each option focusing on major issues relating to viability and commercial potential, and determine additional steps are required to reach this potential.

  4. Advanced method for making vitreous waste forms

    SciTech Connect

    Pope, J.M.; Harrison, D.E.

    1980-01-01

    A process is described for making waste glass that circumvents the problems of dissolving nuclear waste in molten glass at high temperatures. Because the reactive mixing process is independent of the inherent viscosity of the melt, any glass composition can be prepared with equal facility. Separation of the mixing and melting operations permits novel glass fabrication methods to be employed.

  5. Connectomics in psychiatric research: advances and applications.

    PubMed

    Cao, Miao; Wang, Zhijiang; He, Yong

    2015-01-01

    Psychiatric disorders disturb higher cognitive functions and severely compromise human health. However, the pathophysiological mechanisms underlying psychiatric disorders are very complex, and understanding these mechanisms remains a great challenge. Currently, many psychiatric disorders are hypothesized to reflect "faulty wiring" or aberrant connectivity in the brains. Imaging connectomics is arising as a promising methodological framework for describing the structural and functional connectivity patterns of the human brain. Recently, alterations of brain networks in the connectome have been reported in various psychiatric disorders, and these alterations may provide biomarkers for disease diagnosis and prognosis for the evaluation of treatment efficacy. Here, we summarize the current achievements in both the structural and functional connectomes in several major psychiatric disorders (eg, schizophrenia, attention-deficit/hyperactivity disorder, and autism) based on multi-modal neuroimaging data. We highlight the current progress in the identification of these alterations and the hypotheses concerning the aberrant brain networks in individuals with psychiatric disorders and discuss the research questions that might contribute to a further mechanistic understanding of these disorders from a connectomic perspective. PMID:26604764

  6. Research advancements in palm oil nutrition*

    PubMed Central

    May, Choo Yuen; Nesaretnam, Kalanithi

    2014-01-01

    Palm oil is the major oil produced, with annual world production in excess of 50 million tonnes. About 85% of global palm oil produced is used in food applications. Over the past three decades, research on nutritional benefits of palm oil have demonstrated the nutritional adequacy of palm oil and its products, and have resulted in transitions in the understanding these attributes. Numerous studies have demonstrated that palm oil was similar to unsaturated oils with regards to effects on blood lipids. Palm oil provides a healthy alternative to trans-fatty acid containing hydrogenated fats that have been demonstrated to have serious deleterious effects on health. The similar effects of palm oil on blood lipids, comparable to other vegetable oils could very well be due to the structure of the major triglycerides in palm oil, which has an unsaturated fatty acid in the stereospecific numbers (sn)-2 position of the glycerol backbone. In addition, palm oil is well endowed with a bouquet of phytonutrients beneficial to health, such as tocotrienols, carotenoids, and phytosterols. This review will provide an overview of studies that have established palm oil as a balanced and nutritious oil. PMID:25821404

  7. Nanotoxicology: advances and pitfalls in research methodology.

    PubMed

    Azhdarzadeh, Morteza; Saei, Amir Ata; Sharifi, Shahriar; Hajipour, Mohammad J; Alkilany, Alaaldin M; Sharifzadeh, Mohammad; Ramazani, Fatemeh; Laurent, Sophie; Mashaghi, Alireza; Mahmoudi, Morteza

    2015-01-01

    As research progresses, nanoparticles (NPs) are becoming increasingly promising tools for medical diagnostics and therapeutics. Despite this rise, their potential risks to human health, together with environmental issues, has led to increasing concerns regarding their use. As such, a comprehensive understanding of the interactions that occur at the nano-bio interface is required in order to design safe, reliable and efficient NPs for biomedical applications. To this end, extensive studies have been dedicated to probing the factors that define various properties of the nano-bio interface. However, the literature remains unclear and contains conflicting reports on cytotoxicity and biological fates, even for seemingly identical NPs. This uncertainty reveals that we frequently fail to identify and control relevant parameters that unambiguously and reproducibly determine the toxicity of nanoparticles, both in vitro and in vivo. An effective understanding of the toxicological impact of NPs requires the consideration of relevant factors, including the temperature of the target tissue, plasma gradient, cell shape, interfacial effects and personalized protein corona. In this review, we discuss the factors that play a critical role in nano-bio interface processes and nanotoxicity. A proper combinatorial assessment of these factors substantially changes our insight into the cytotoxicity, distribution and biological fate of NPs.

  8. [Research Advances in the Porcine Deltacoronavirus].

    PubMed

    Fang, Puxian; Fang, Liurong; Dong, Nan; Xiao, Shaobo

    2016-03-01

    The deltacoronavirus is a new member of the subfamily Coronaviridae of the family Coronaviridae. Deltacoronaviruses can infect birds and mammals. Deltacoronaviruses were detected in early 2007 in Asian leopard cats and Chinese ferret badgers. In 2014, porcine deltacoronavirus (PDCoV) infection spread rapidly in the USA. Moreover, cell culture-adapted PDCoV has been obtained from infected piglets. Animal experiments have confirmed that the isolated PDCoV is highly pathogenic and causes severe diarrhea in piglets. Thus, the PDCoV can be considered to be a good model to study the deltacoronavirus. In this review, we discuss the etiology, epidemiology, pathogenicity, culture, and diagnostic methods of the PDCoV. PMID:27396171

  9. Advanced fiber optic seismic sensors (geophone) research

    NASA Astrophysics Data System (ADS)

    Zhang, Yan

    The systematical research on the fiber optic seismic sensors based on optical Fiber Bragg Grating (FBG) sensing technology is presented in this thesis. Optical fiber sensors using fiber Bragg gratings have a number of advantages such as immunity to electromagnetic interference, lightweight, low power consumption. The FBG sensor is intrinsically sensitive to dynamic strain signals and the strain sensitivity can approach sub micro-strain. Furthermore, FBG sensors are inherently suited for multiplexing, which makes possible networked/arrayed deployment on a large scale. The basic principle of the FBG geophone is that it transforms the acceleration of ground motion into the strain signal of the FBG sensor through mechanical design, and after the optical demodulation generates the analog voltage output proportional to the strain changes. The customized eight-channel FBG seismic sensor prototype is described here which consists of FBG sensor/demodulation grating pairs attached on the spring-mass mechanical system. The sensor performance is evaluated systematically in the laboratory using the conventional accelerometer and geophone as the benchmark, Two major applications of FBG seismic sensor are demonstrated. One is in the battlefield remote monitoring system to detect the presence of personnel, wheeled vehicles, and tracked vehicles. The other application is in the seismic reflection survey of oilfield exploration to collect the seismic waves from the earth. The field tests were carried out in the air force base and the oilfield respectively. It is shown that the FBG geophone has higher frequency response bandwidth and sensitivity than conventional moving-coil electromagnetic geophone and the military Rembass-II S/A sensor. Our objective is to develop a distributed FBG seismic sensor network to recognize and locate the presence of seismic sources with high inherent detection capability and a low false alarm rate in an integrated system.

  10. 11th Annual NIH Pain Consortium Symposium on Advances in Pain Research | Division of Cancer Prevention

    Cancer.gov

    The NIH Pain Consortium will convene the 11th Annual NIH Pain Consortium Symposium on Advances in Pain Research, featuring keynote speakers and expert panel sessions on Innovative Models and Methods. The first keynote address will be delivered by David J. Clark, MD, PhD, Stanford University entitled “Challenges of Translational Pain Research: What Makes a Good Model?” |

  11. Advanced electromagnetic methods for aerospace vehicles

    NASA Technical Reports Server (NTRS)

    Balanis, Constantine A.; El-Sharawy, El-Budawy; Hashemi-Yeganeh, Shahrokh; Aberle, James T.; Birtcher, Craig R.

    1991-01-01

    During this period the research program addressed the following three topics: (1) composite materials; (2) precipitation static (P-Static); and (3) antenna technology. On the topic of Composite Materials our main efforts were directed toward making measurements on several new samples of composite materials made available to ASU by Stanford Research Institute (SRI) through the efforts of Mr. Frank Casler of AVRADA. These samples can be classified into three distinct materials with each material having its own distinct electrical properties. In addition, attempts were made to make predictions of the effects on antenna patterns by composite materials. This will take a greater emphasis in the next reporting period. In Precipitation Static (P-Static), the main effort was devoted toward developing a Voltage Finite-Difference Time-Domain computer code to account for the voltage variation on a conducting body as the primary source of corona discharge, instead of the electric field. Due to complexities stemming from the interactions between the potentials, the fields, and current sources, the decision was made to begin with a simple two-dimensional problem without the corona discharge and check our programs in a series of simple models, culminating in the full corona discharge problem. This report deals with the first stage of such development. During this reporting period, the main effort in Antenna Technology was toward the design, fabrication, and testing of a cavity-backed slot antenna using ferrite material. Using the ferrite material available to us during this period, the resonances of this antenna were around 5 and 8 GHz. Attempts will be made to model such an antenna and to lower its resonance down into the VHF and UHF bands.

  12. Magnetized Target Fusion in Advanced Propulsion Research

    NASA Technical Reports Server (NTRS)

    Cylar, Rashad

    2003-01-01

    The Magnetized Target Fusion (MTF) Propulsion lab at NASA Marshall Space Flight Center in Huntsville, Alabama has a program in place that has adopted to attempt to create a faster, lower cost and more reliable deep space transportation system. In this deep space travel the physics and development of high velocity plasma jets must be understood. The MTF Propulsion lab is also in attempt to open up the solar system for human exploration and commercial use. Fusion, as compared to fission, is just the opposite. Fusion involves the light atomic nuclei combination to produce denser nuclei. In the process, the energy is created by destroying the mass according to the distinguished equation: E = mc2 . Fusion energy development is being pursued worldwide as a very sustainable form of energy that is environmentally friendly. For the purposes of space exploration fusion reactions considered include the isotopes of hydrogen-deuterium (D2) and tritium (T3). Nuclei have an electrostatic repulsion between them and in order for the nuclei to fuse this repulsion must be overcome. One technique to bypass repulsion is to heat the nuclei to very high temperatures. The temperatures vary according to the type of reactions. For D-D reactions, one billion degrees Celsius is required, and for D-T reactions, one hundred million degrees is sufficient. There has to be energy input for useful output to be obtained form the fusion To make fusion propulsion practical, the mass, the volume, and the cost of the equipment to produce the reactions (generally called the reactor) need to be reduced by an order of magnitude or two from the state-of-the-art fusion machines. Innovations in fusion schemes are therefore required, especially for obtaining thrust for propulsive applications. Magnetized target fusion (MTF) is one of the innovative fusion concepts that have emerged over the last several years. MSFC is working with Los Alamos National Laboratory and other research groups in studying the

  13. Analytical and numerical methods; advanced computer concepts

    SciTech Connect

    Lax, P D

    1991-03-01

    This past year, two projects have been completed and a new is under way. First, in joint work with R. Kohn, we developed a numerical algorithm to study the blowup of solutions to equations with certain similarity transformations. In the second project, the adaptive mesh refinement code of Berger and Colella for shock hydrodynamic calculations has been parallelized and numerical studies using two different shared memory machines have been done. My current effort is towards the development of Cartesian mesh methods to solve pdes with complicated geometries. Most of the coming year will be spent on this project, which is joint work with Prof. Randy Leveque at the University of Washington in Seattle.

  14. Advanced diagnostic methods in oral and maxillofacial pathology. Part II: immunohistochemical and immunofluorescent methods.

    PubMed

    Jordan, Richard C K; Daniels, Troy E; Greenspan, John S; Regezi, Joseph A

    2002-01-01

    The practice of pathology is currently undergoing significant change, in large part due to advances in the analysis of DNA, RNA, and proteins in tissues. These advances have permitted improved biologic insights into many developmental, inflammatory, metabolic, infectious, and neoplastic diseases. Moreover, molecular analysis has also led to improvements in the accuracy of disease diagnosis and classification. It is likely that, in the future, these methods will increasingly enter into the day-to-day diagnosis and management of patients. The pathologist will continue to play a fundamental role in diagnosis and will likely be in a pivotal position to guide the implementation and interpretation of these tests as they move from the research laboratory into diagnostic pathology. The purpose of this 2-part series is to provide an overview of the principles and applications of current molecular biologic and immunologic tests. In Part I, the biologic fundamentals of DNA, RNA, and proteins and methods that are currently available or likely to become available to the pathologist in the next several years for their isolation and analysis in tissue biopsies were discussed. In Part II, advances in immunohistochemistry and immunofluorescence methods and their application to modern diagnostic pathology are reviewed. PMID:11805778

  15. Current methods and advances in bone densitometry

    NASA Technical Reports Server (NTRS)

    Guglielmi, G.; Gluer, C. C.; Majumdar, S.; Blunt, B. A.; Genant, H. K.

    1995-01-01

    Bone mass is the primary, although not the only, determinant of fracture. Over the past few years a number of noninvasive techniques have been developed to more sensitively quantitate bone mass. These include single and dual photon absorptiometry (SPA and DPA), single and dual X-ray absorptiometry (SXA and DXA) and quantitative computed tomography (QCT). While differing in anatomic sites measured and in their estimates of precision, accuracy, and fracture discrimination, all of these methods provide clinically useful measurements of skeletal status. It is the intent of this review to discuss the pros and cons of these techniques and to present the new applications of ultrasound (US) and magnetic resonance (MRI) in the detection and management of osteoporosis.

  16. Advanced 3D Optical Microscopy in ENS Research.

    PubMed

    Vanden Berghe, Pieter

    2016-01-01

    Microscopic techniques are among the few approaches that have survived the test of time. Being invented half way the seventeenth century by Antonie van Leeuwenhoek and Robert Hooke, this technology is still essential in modern biomedical labs. Many microscopy techniques have been used in ENS research to guide researchers in their dissections and later to enable electrode recordings. Apart from this, microscopy has been instrumental in the identification of subpopulations of cells in the ENS, using a variety of staining methods. A significant step forward in the use of microscopy was the introduction of fluorescence approaches. Due to the fact that intense excitation light is now filtered away from the longer wavelength emission light, the contrast can be improved drastically, which helped to identify subpopulations of enteric neurons in a variety of species. Later functionalized fluorescent probes were used to measure and film activity in muscle and neuronal cells. Another important impetus to the use of microscopy was the discovery and isolation of the green fluorescent protein (GFP), as it gave rise to the development of many different color variants and functionalized constructs. Recent advances in microscopy are the result of a continuous search to enhance contrast between the item of interest and its background but also to improve resolving power to tell two small objects apart. In this chapter three different microscopy approaches will be discussed that can aid to improve our understanding of ENS function within the gut wall. PMID:27379646

  17. Advanced 3D Optical Microscopy in ENS Research.

    PubMed

    Vanden Berghe, Pieter

    2016-01-01

    Microscopic techniques are among the few approaches that have survived the test of time. Being invented half way the seventeenth century by Antonie van Leeuwenhoek and Robert Hooke, this technology is still essential in modern biomedical labs. Many microscopy techniques have been used in ENS research to guide researchers in their dissections and later to enable electrode recordings. Apart from this, microscopy has been instrumental in the identification of subpopulations of cells in the ENS, using a variety of staining methods. A significant step forward in the use of microscopy was the introduction of fluorescence approaches. Due to the fact that intense excitation light is now filtered away from the longer wavelength emission light, the contrast can be improved drastically, which helped to identify subpopulations of enteric neurons in a variety of species. Later functionalized fluorescent probes were used to measure and film activity in muscle and neuronal cells. Another important impetus to the use of microscopy was the discovery and isolation of the green fluorescent protein (GFP), as it gave rise to the development of many different color variants and functionalized constructs. Recent advances in microscopy are the result of a continuous search to enhance contrast between the item of interest and its background but also to improve resolving power to tell two small objects apart. In this chapter three different microscopy approaches will be discussed that can aid to improve our understanding of ENS function within the gut wall.

  18. Advanced electromagnetic methods for aerospace vehicles

    NASA Technical Reports Server (NTRS)

    Balanis, Constantine A.; Choi, Jachoon; El-Sharawy, El-Budawy; Hashemi-Yeganeh, Shahrokh; Birtcher, Craig R.

    1990-01-01

    High- and low-frequency methods to analyze various radiation elements located on aerospace vehicles with combinations of conducting, nonconducting, and energy absorbing surfaces and interfaces. The focus was on developing fundamental concepts, techniques, and algorithms which would remove some of the present limitations in predicting radiation characteristics of antennas on complex aerospace vehicles. In order to accomplish this, the following subjects were examined: (1) the development of techniques for rigorous analysis of surface discontinuities of metallic and nonmetallic surfaces using the equivalent surface impedance concept and Green's function; (2) the effects of anisotropic material on antenna radiation patterns through the use of an equivalent surface impedance concept which is incorporated into the existing numerical electromagnetics computer codes; and (3) the fundamental concepts of precipitation static (P-Static), such as formulations and analytical models. A computer code was used to model the P-Static process on a simple structure. Measurement techniques were also developed to characterized the electrical properties at microwave frequencies. Samples of typical materials used in airframes were tested and the results are included.

  19. Advanced Fuzzy Potential Field Method for Mobile Robot Obstacle Avoidance

    PubMed Central

    Park, Jong-Wook; Kwak, Hwan-Joo; Kang, Young-Chang; Kim, Dong W.

    2016-01-01

    An advanced fuzzy potential field method for mobile robot obstacle avoidance is proposed. The potential field method primarily deals with the repulsive forces surrounding obstacles, while fuzzy control logic focuses on fuzzy rules that handle linguistic variables and describe the knowledge of experts. The design of a fuzzy controller—advanced fuzzy potential field method (AFPFM)—that models and enhances the conventional potential field method is proposed and discussed. This study also examines the rule-explosion problem of conventional fuzzy logic and assesses the performance of our proposed AFPFM through simulations carried out using a mobile robot. PMID:27123001

  20. Advanced Fuzzy Potential Field Method for Mobile Robot Obstacle Avoidance.

    PubMed

    Park, Jong-Wook; Kwak, Hwan-Joo; Kang, Young-Chang; Kim, Dong W

    2016-01-01

    An advanced fuzzy potential field method for mobile robot obstacle avoidance is proposed. The potential field method primarily deals with the repulsive forces surrounding obstacles, while fuzzy control logic focuses on fuzzy rules that handle linguistic variables and describe the knowledge of experts. The design of a fuzzy controller--advanced fuzzy potential field method (AFPFM)--that models and enhances the conventional potential field method is proposed and discussed. This study also examines the rule-explosion problem of conventional fuzzy logic and assesses the performance of our proposed AFPFM through simulations carried out using a mobile robot. PMID:27123001

  1. Advancing MODFLOW Applying the Derived Vector Space Method

    NASA Astrophysics Data System (ADS)

    Herrera, G. S.; Herrera, I.; Lemus-García, M.; Hernandez-Garcia, G. D.

    2015-12-01

    The most effective domain decomposition methods (DDM) are non-overlapping DDMs. Recently a new approach, the DVS-framework, based on an innovative discretization method that uses a non-overlapping system of nodes (the derived-nodes), was introduced and developed by I. Herrera et al. [1, 2]. Using the DVS-approach a group of four algorithms, referred to as the 'DVS-algorithms', which fulfill the DDM-paradigm (i.e. the solution of global problems is obtained by resolution of local problems exclusively) has been derived. Such procedures are applicable to any boundary-value problem, or system of such equations, for which a standard discretization method is available and then software with a high degree of parallelization can be constructed. In a parallel talk, in this AGU Fall Meeting, Ismael Herrera will introduce the general DVS methodology. The application of the DVS-algorithms has been demonstrated in the solution of several boundary values problems of interest in Geophysics. Numerical examples for a single-equation, for the cases of symmetric, non-symmetric and indefinite problems were demonstrated before [1,2]. For these problems DVS-algorithms exhibited significantly improved numerical performance with respect to standard versions of DDM algorithms. In view of these results our research group is in the process of applying the DVS method to a widely used simulator for the first time, here we present the advances of the application of this method for the parallelization of MODFLOW. Efficiency results for a group of tests will be presented. References [1] I. Herrera, L.M. de la Cruz and A. Rosas-Medina. Non overlapping discretization methods for partial differential equations, Numer Meth Part D E, (2013). [2] Herrera, I., & Contreras Iván "An Innovative Tool for Effectively Applying Highly Parallelized Software To Problems of Elasticity". Geofísica Internacional, 2015 (In press)

  2. Underwater Photosynthesis of Submerged Plants – Recent Advances and Methods

    PubMed Central

    Pedersen, Ole; Colmer, Timothy D.; Sand-Jensen, Kaj

    2013-01-01

    We describe the general background and the recent advances in research on underwater photosynthesis of leaf segments, whole communities, and plant dominated aquatic ecosystems and present contemporary methods tailor made to quantify photosynthesis and carbon fixation under water. The majority of studies of aquatic photosynthesis have been carried out with detached leaves or thalli and this selectiveness influences the perception of the regulation of aquatic photosynthesis. We thus recommend assessing the influence of inorganic carbon and temperature on natural aquatic communities of variable density in addition to studying detached leaves in the scenarios of rising CO2 and temperature. Moreover, a growing number of researchers are interested in tolerance of terrestrial plants during flooding as torrential rains sometimes result in overland floods that inundate terrestrial plants. We propose to undertake studies to elucidate the importance of leaf acclimation of terrestrial plants to facilitate gas exchange and light utilization under water as these acclimations influence underwater photosynthesis as well as internal aeration of plant tissues during submergence. PMID:23734154

  3. Advanced technology airfoil research, volume 1, part 2

    NASA Technical Reports Server (NTRS)

    1978-01-01

    This compilation contains papers presented at the NASA Conference on Advanced Technology Airfoil Research held at Langley Research Center on March 7-9, 1978, which have unlimited distribution. This conference provided a comprehensive review of all NASA airfoil research, conducted in-house and under grant and contract. A broad spectrum of airfoil research outside of NASA was also reviewed. The major thrust of the technical sessions were in three areas: development of computational aerodynamic codes for airfoil analysis and design, development of experimental facilities and test techniques, and all types of airfoil applications.

  4. Construction of databases: advances and significance in clinical research.

    PubMed

    Long, Erping; Huang, Bingjie; Wang, Liming; Lin, Xiaoyu; Lin, Haotian

    2015-12-01

    Widely used in clinical research, the database is a new type of data management automation technology and the most efficient tool for data management. In this article, we first explain some basic concepts, such as the definition, classification, and establishment of databases. Afterward, the workflow for establishing databases, inputting data, verifying data, and managing databases is presented. Meanwhile, by discussing the application of databases in clinical research, we illuminate the important role of databases in clinical research practice. Lastly, we introduce the reanalysis of randomized controlled trials (RCTs) and cloud computing techniques, showing the most recent advancements of databases in clinical research. PMID:27215009

  5. Major clinical research advances in gynecologic cancer in 2014.

    PubMed

    Suh, Dong Hoon; Lee, Kyung Hun; Kim, Kidong; Kang, Sokbom; Kim, Jae Weon

    2015-04-01

    In 2014, 9 topics were selected as major advances in clinical research for gynecologic oncology: 2 each in cervical and corpus cancer, 4 in ovarian cancer, and 1 in breast cancer. For cervical cancer, several therapeutic agents showed viable antitumor clinical response in recurrent and metastatic disease: bevacizumab, cediranib, and immunotherapies including human papillomavirus (HPV)-tumor infiltrating lymphocytes and Z-100. The HPV test received FDA approval as the primary screening tool of cervical cancer in women aged 25 and older, based on the results of the ATHENA trial, which suggested that the HPV test was a more sensitive and efficient strategy for cervical cancer screening than methods based solely on cytology. For corpus cancers, results of a phase III Gynecologic Oncology Group (GOG) 249 study of early-stage endometrial cancer with high-intermediate risk factors are followed by the controversial topic of uterine power morcellation in minimally invasive gynecologic surgery. Promising results of phase II studies regarding the effectiveness of olaparib in various ovarian cancer settings are summarized. After a brief review of results from a phase III study on pazopanib maintenance therapy in advanced ovarian cancer, 2 outstanding 2014 ASCO presentations cover the topic of using molecular subtypes in predicting response to bevacizumab. A review of the use of opportunistic bilateral salpingectomy as an ovarian cancer preventive strategy in the general population is presented. Two remarkable studies that discussed the effectiveness of adjuvant ovarian suppression in premenopausal early breast cancer have been selected as the last topics covered in this review. PMID:25872896

  6. [Research advance in rare and endemic plant Tetraena mongolica Maxim].

    PubMed

    Zhen, Jiang-Hong; Liu, Guo-Hou

    2008-02-01

    In this paper, the research advance in rare and endemic plant Tetraena mongolica Maxim. was summarized from the aspects of morphology, anatomy, palynology, cytology, seed-coat micro-morphology, embryology, physiology, biology, ecology, genetic diversity, chemical constituents, endangered causes, and conservation approaches, and the further research directions were prospected. It was considered that population viability, idioplasm conservation and artificial renewal, molecular biology of ecological adaptability, and assessment of habitat suitability should be the main aspects for the future study of T. mongolica.

  7. INL Advanced Radiotherapy Research Program Annual Report 2004

    SciTech Connect

    James Venhuizen

    2005-06-01

    This report summarizes the activities and major accomplishments for the Idaho National Laboratory Advanced Radiotherapy Research Program for calendar year 2004. Topics covered include boron analysis in biological samples, computational dosimetry and treatment planning software development, medical neutron source development and characterization, and collaborative dosimetry studies at the RA-1 facility in Buenos Aires, Argentina.

  8. Advanced materials research for long-haul aircraft turbine engines

    NASA Technical Reports Server (NTRS)

    Signorelli, R. A.; Blankenship, C. P.

    1978-01-01

    The status of research efforts to apply low to intermediate temperature composite materials and advanced high temperature materials to engine components is reviewed. Emerging materials technologies and their potential benefits to aircraft gas turbines were emphasized. The problems were identified, and the general state of the technology for near term use was assessed.

  9. Advanced Composite Structures At NASA Langley Research Center

    NASA Technical Reports Server (NTRS)

    Eldred, Lloyd B.

    2015-01-01

    Dr. Eldred's presentation will discuss several NASA efforts to improve and expand the use of composite structures within aerospace vehicles. Topics will include an overview of NASA's Advanced Composites Project (ACP), Space Launch System (SLS) applications, and Langley's ISAAC robotic composites research tool.

  10. INEEL Advanced Radiotherapy Research Program Annual Report for 2002

    SciTech Connect

    J. R. Venhuizen

    2003-05-01

    This report summarizes the activities and major accomplishments for the Idaho National Engineering and Environmental Laboratory (INEEL) Advanced Radiotherapy Research Program for calendar year 2002. Topics covered include computational dosimetry and treatment planning software development, medical neutron source development and characterization, and boron analytical chemistry.

  11. INEEL Advanced Radiotherapy Research Program Annual Report 2002

    SciTech Connect

    Venhuizen, J.R.

    2003-05-23

    This report summarizes the activities and major accomplishments for the Idaho National Engineering and Environmental Laboratory (INEEL) Advanced Radiotherapy Research Program for calendar year 2002. Topics covered include computational dosimetry and treatment planning software development, medical neutron source development and characterization, and boron analytical chemistry.

  12. Advancing underactive bladder research through public-private collaboration.

    PubMed

    Chancellor, David D

    2014-09-01

    Underactive bladder (UAB) represents an unmet medical need. The proceeds of the 1st international CURE-UAB support allocation of resources and attention via public-private partnerships to advance UAB research. Small investments on the part of public institutes in collaboration with the private sectors can vanguard a serious and sustained global effort toward helping UAB patients.

  13. Summary of Advances in Autism Spectrum Disorder Research, 2009

    ERIC Educational Resources Information Center

    Interagency Autism Coordinating Committee, 2009

    2009-01-01

    Each year the members of the Interagency Autism Coordinating Committee identify recent research findings that made the most impact on the field. For the 2009 Summary of Advances, the IACC selected and summarized 20 studies that gave significant insight into the prevalence of autism spectrum disorder (ASD), the biology of the disorder, potential…

  14. Research using qualitative, quantitative or mixed methods and choice based on the research.

    PubMed

    McCusker, K; Gunaydin, S

    2015-10-01

    Research is fundamental to the advancement of medicine and critical to identifying the most optimal therapies unique to particular societies. This is easily observed through the dynamics associated with pharmacology, surgical technique and the medical equipment used today versus short years ago. Advancements in knowledge synthesis and reporting guidelines enhance the quality, scope and applicability of results; thus, improving health science and clinical practice and advancing health policy. While advancements are critical to the progression of optimal health care, the high cost associated with these endeavors cannot be ignored. Research fundamentally needs to be evaluated to identify the most efficient methods of evaluation. The primary objective of this paper is to look at a specific research methodology when applied to the area of clinical research, especially extracorporeal circulation and its prognosis for the future.

  15. Advanced Ablative Insulators and Methods of Making Them

    NASA Technical Reports Server (NTRS)

    Congdon, William M.

    2005-01-01

    Advanced ablative (more specifically, charring) materials that provide temporary protection against high temperatures, and advanced methods of designing and manufacturing insulators based on these materials, are undergoing development. These materials and methods were conceived in an effort to replace the traditional thermal-protection systems (TPSs) of re-entry spacecraft with robust, lightweight, better-performing TPSs that can be designed and manufactured more rapidly and at lower cost. These materials and methods could also be used to make improved TPSs for general aerospace, military, and industrial applications.

  16. Test Method Designed to Evaluate Cylinder Liner-Piston Ring Coatings for Advanced Heat Engines

    NASA Technical Reports Server (NTRS)

    Radil, Kevin C.

    1997-01-01

    Research on advanced heat engine concepts, such as the low-heat-rejection engine, have shown the potential for increased thermal efficiency, reduced emissions, lighter weight, simpler design, and longer life in comparison to current diesel engine designs. A major obstacle in the development of a functional advanced heat engine is overcoming the problems caused by the high combustion temperatures at the piston ring/cylinder liner interface, specifically at top ring reversal (TRR). Therefore, advanced cylinder liner and piston ring materials are needed that can survive under these extreme conditions. To address this need, researchers at the NASA Lewis Research Center have designed a tribological test method to help evaluate candidate piston ring and cylinder liner materials for advanced diesel engines.

  17. CSM research: Methods and application studies

    NASA Technical Reports Server (NTRS)

    Knight, Norman F., Jr.

    1989-01-01

    Computational mechanics is that discipline of applied science and engineering devoted to the study of physical phenomena by means of computational methods based on mathematical modeling and simulation, utilizing digital computers. The discipline combines theoretical and applied mechanics, approximation theory, numerical analysis, and computer science. Computational mechanics has had a major impact on engineering analysis and design. When applied to structural mechanics, the discipline is referred to herein as computational structural mechanics. Complex structures being considered by NASA for the 1990's include composite primary aircraft structures and the space station. These structures will be much more difficult to analyze than today's structures and necessitate a major upgrade in computerized structural analysis technology. NASA has initiated a research activity in structural analysis called Computational Structural Mechanics (CSM). The broad objective of the CSM activity is to develop advanced structural analysis technology that will exploit modern and emerging computers, such as those with vector and/or parallel processing capabilities. Here, the current research directions for the Methods and Application Studies Team of the Langley CSM activity are described.

  18. Advanced Life Support Research and Technology Development Metric

    NASA Technical Reports Server (NTRS)

    Hanford, A. J.

    2004-01-01

    The Metric is one of several measures employed by the NASA to assess the Agency s progress as mandated by the United States Congress and the Office of Management and Budget. Because any measure must have a reference point, whether explicitly defined or implied, the Metric is a comparison between a selected ALS Project life support system and an equivalently detailed life support system using technology from the Environmental Control and Life Support System (ECLSS) for the International Space Station (ISS). This document provides the official calculation of the Advanced Life Support (ALS) Research and Technology Development Metric (the Metric) for Fiscal Year 2004. The values are primarily based on Systems Integration, Modeling, and Analysis (SIMA) Element approved software tools or reviewed and approved reference documents. For Fiscal Year 2004, the Advanced Life Support Research and Technology Development Metric value is 2.03 for an Orbiting Research Facility and 1.62 for an Independent Exploration Mission.

  19. A Primer In Advanced Fatigue Life Prediction Methods

    NASA Technical Reports Server (NTRS)

    Halford, Gary R.

    2000-01-01

    Metal fatigue has plagued structural components for centuries, and it remains a critical durability issue in today's aerospace hardware. This is true despite vastly improved and advanced materials, increased mechanistic understanding, and development of accurate structural analysis and advanced fatigue life prediction tools. Each advance is quickly taken advantage of to produce safer, more reliable more cost effective, and better performing products. In other words, as the envelop is expanded, components are then designed to operate just as close to the newly expanded envelop as they were to the initial one. The problem is perennial. The economic importance of addressing structural durability issues early in the design process is emphasized. Tradeoffs with performance, cost, and legislated restrictions are pointed out. Several aspects of structural durability of advanced systems, advanced materials and advanced fatigue life prediction methods are presented. Specific items include the basic elements of durability analysis, conventional designs, barriers to be overcome for advanced systems, high-temperature life prediction for both creep-fatigue and thermomechanical fatigue, mean stress effects, multiaxial stress-strain states, and cumulative fatigue damage accumulation assessment.

  20. Hydrogen production from water: Recent advances in photosynthesis research

    SciTech Connect

    Greenbaum, E.; Lee, J.W.

    1997-12-31

    The great potential of hydrogen production by microalgal water splitting is predicated on quantitative measurement of the algae`s hydrogen-producing capability, which is based on the following: (1) the photosynthetic unit size of hydrogen production; (2) the turnover time of photosynthetic hydrogen production; (3) thermodynamic efficiencies of conversion of light energy into the Gibbs free energy of molecular hydrogen; (4) photosynthetic hydrogen production from sea water using marine algae; (5) the potential for research advances using modern methods of molecular biology and genetic engineering to maximize hydrogen production. ORNL has shown that sustained simultaneous photoevolution of molecular hydrogen and oxygen can be performed with mutants of the green alga Chlamydomonas reinhardtii that lack a detectable level of the Photosystem I light reaction. This result is surprising in view of the standard two-light reaction model of photosynthesis and has interesting scientific and technological implications. This ORNL discovery also has potentially important implications for maximum thermodynamic conversion efficiency of light energy into chemical energy by green plant photosynthesis. Hydrogen production performed by a single light reaction, as opposed to two, implies a doubling of the theoretically maximum thermodynamic conversion efficiency from {approx}10% to {approx}20%.

  1. Advanced Propulsion Research Interest in Materials for Propulsion

    NASA Technical Reports Server (NTRS)

    Cole, John

    2003-01-01

    This viewgraph presentation provides an overview of material science and technology in the area of propulsion energetics. The authors note that conventional propulsion systems are near peak performance and further refinements in manufacturing, engineering design and materials will only provide incremental increases in performance. Energetic propulsion technologies could potential solve the problems of energy storage density and energy-to-thrust conversion efficiency. Topics considered include: the limits of thermal propulsion systems, the need for energetic propulsion research, emerging energetic propulsion technologies, materials research needed for advanced propulsion, and potential research opportunities.

  2. First Aviation System Technology Advanced Research (AvSTAR) Workshop

    NASA Technical Reports Server (NTRS)

    Denery, Dallas G. (Editor); Weathers, Del W. (Editor); Rosen, Robert (Technical Monitor); Edwards, Tom (Technical Monitor)

    2001-01-01

    This Conference Proceedings documents the results of a two-day NASA/FAA/Industry workshop that was held at the NASA Ames Research Center, located at Moffett Field, CA, on September 21-22, 2000. The purpose of the workshop was to bring together a representative cross section of leaders in air traffic management, from industry. FAA, and academia, to assist in defining the requirements for a new research effort, referred to as AvSTAR Aviation Systems Technology Advanced Research). The Conference Proceedings includes the individual presentation, and summarizes the workshop discussions and recommendations.

  3. Advanced stress analysis methods applicable to turbine engine structures

    NASA Technical Reports Server (NTRS)

    Pian, T. H. H.

    1985-01-01

    Advanced stress analysis methods applicable to turbine engine structures are investigated. Constructions of special elements which containing traction-free circular boundaries are investigated. New versions of mixed variational principle and version of hybrid stress elements are formulated. A method is established for suppression of kinematic deformation modes. semiLoof plate and shell elements are constructed by assumed stress hybrid method. An elastic-plastic analysis is conducted by viscoplasticity theory using the mechanical subelement model.

  4. Advanced surface paneling method for subsonic and supersonic flow

    NASA Technical Reports Server (NTRS)

    Erickson, L. L.; Johnson, F. T.; Ehlers, F. E.

    1976-01-01

    Numerical results illustrating the capabilities of an advanced aerodynamic surface paneling method are presented. The method is applicable to both subsonic and supersonic flow, as represented by linearized potential flow theory. The method is based on linearly varying sources and quadratically varying doublets which are distributed over flat or curved panels. These panels are applied to the true surface geometry of arbitrarily shaped three dimensional aerodynamic configurations.

  5. Bioinformatics Methods and Tools to Advance Clinical Care

    PubMed Central

    Lecroq, T.

    2015-01-01

    Summary Objectives To summarize excellent current research in the field of Bioinformatics and Translational Informatics with application in the health domain and clinical care. Method We provide a synopsis of the articles selected for the IMIA Yearbook 2015, from which we attempt to derive a synthetic overview of current and future activities in the field. As last year, a first step of selection was performed by querying MEDLINE with a list of MeSH descriptors completed by a list of terms adapted to the section. Each section editor has evaluated separately the set of 1,594 articles and the evaluation results were merged for retaining 15 articles for peer-review. Results The selection and evaluation process of this Yearbook’s section on Bioinformatics and Translational Informatics yielded four excellent articles regarding data management and genome medicine that are mainly tool-based papers. In the first article, the authors present PPISURV a tool for uncovering the role of specific genes in cancer survival outcome. The second article describes the classifier PredictSNP which combines six performing tools for predicting disease-related mutations. In the third article, by presenting a high-coverage map of the human proteome using high resolution mass spectrometry, the authors highlight the need for using mass spectrometry to complement genome annotation. The fourth article is also related to patient survival and decision support. The authors present datamining methods of large-scale datasets of past transplants. The objective is to identify chances of survival. Conclusions The current research activities still attest the continuous convergence of Bioinformatics and Medical Informatics, with a focus this year on dedicated tools and methods to advance clinical care. Indeed, there is a need for powerful tools for managing and interpreting complex, large-scale genomic and biological datasets, but also a need for user-friendly tools developed for the clinicians in their

  6. [Activities of Research Institute for Advanced Computer Science

    NASA Technical Reports Server (NTRS)

    Gross, Anthony R. (Technical Monitor); Leiner, Barry M.

    2001-01-01

    The Research Institute for Advanced Computer Science (RIACS) carries out basic research and technology development in computer science, in support of the National Aeronautics and Space Administrations missions. RIACS is located at the NASA Ames Research Center, Moffett Field, California. RIACS research focuses on the three cornerstones of IT research necessary to meet the future challenges of NASA missions: 1. Automated Reasoning for Autonomous Systems Techniques are being developed enabling spacecraft that will be self-guiding and self-correcting to the extent that they will require little or no human intervention. Such craft will be equipped to independently solve problems as they arise, and fulfill their missions with minimum direction from Earth. 2. Human-Centered Computing Many NASA missions require synergy between humans and computers, with sophisticated computational aids amplifying human cognitive and perceptual abilities. 3. High Performance Computing and Networking Advances in the performance of computing and networking continue to have major impact on a variety of NASA endeavors, ranging from modeling and simulation to analysis of large scientific datasets to collaborative engineering, planning and execution. In addition, RIACS collaborates with NASA scientists to apply IT research to a variety of NASA application domains. RIACS also engages in other activities, such as workshops, seminars, visiting scientist programs and student summer programs, designed to encourage and facilitate collaboration between the university and NASA IT research communities.

  7. Advanced Physics Labs and Undergraduate Research: Helping Them Work Together

    NASA Astrophysics Data System (ADS)

    Peterson, Richard W.

    2009-10-01

    The 2009 Advanced Lab Topical Conference in Ann Arbor affirmed the importance of advanced labs that teach crucial skills and methodologies by carefully conducting a time-honored experiment. Others however argued that such a constrained experiment can play a complementary role to more open-ended, project experiences. A genuine ``experiment'' where neither student or faculty member is exactly sure of the best approach or anticipated result can often trigger real excitement, creativity, and career direction for students while reinforcing the advanced lab and undergraduate research interface. Several examples are cited in areas of AMO physics, optics, fluids, and acoustics. Colleges and universities that have dual-degree engineering, engineering physics, or applied physics programs may especially profit from interdisciplinary projects that utilize optical, electromagnetic, and acoustical measurements in conjunction with computational physics and simulation.

  8. A Review of Radiotherapy-Induced Late Effects Research after Advanced Technology Treatments

    PubMed Central

    Newhauser, Wayne D.; de Gonzalez, Amy Berrington; Schulte, Reinhard; Lee, Choonsik

    2016-01-01

    The number of incident cancers and long-term cancer survivors is expected to increase substantially for at least a decade. Advanced technology radiotherapies, e.g., using beams of protons and photons, offer dosimetric advantages that theoretically yield better outcomes. In general, evidence from controlled clinical trials and epidemiology studies are lacking. To conduct these studies, new research methods and infrastructure will be needed. In the paper, we review several key research methods of relevance to late effects after advanced technology proton-beam and photon-beam radiotherapies. In particular, we focus on the determination of exposures to therapeutic and stray radiation and related uncertainties, with discussion of recent advances in exposure calculation methods, uncertainties, in silico studies, computing infrastructure, electronic medical records, and risk visualization. We identify six key areas of methodology and infrastructure that will be needed to conduct future outcome studies of radiation late effects. PMID:26904500

  9. Regenerative medicine: advances in new methods and technologies.

    PubMed

    Park, Dong-Hyuk; Eve, David J

    2009-11-01

    The articles published in the journal Cell Transplantation - The Regenerative Medicine Journal over the last two years reveal the recent and future cutting-edge research in the fields of regenerative and transplantation medicine. 437 articles were published from 2007 to 2008, a 17% increase compared to the 373 articles in 2006-2007. Neuroscience was still the most common section in both the number of articles and the percentage of all manuscripts published. The increasing interest and rapid advance in bioengineering technology is highlighted by tissue engineering and bioartificial organs being ranked second again. For a similar reason, the methods and new technologies section increased significantly compared to the last period. Articles focusing on the transplantation of stem cell lineages encompassed almost 20% of all articles published. By contrast, the non-stem cell transplantation group which is made up primarily of islet cells, followed by biomaterials and fetal neural tissue, etc. comprised less than 15%. Transplantation of cells pre-treated with medicine or gene transfection to prolong graft survival or promote differentiation into the needed phenotype, was prevalent in the transplantation articles regardless of the kind of cells used. Meanwhile, the majority of non-transplantation-based articles were related to new devices for various purposes, characterization of unknown cells, medicines, cell preparation and/or optimization for transplantation (e.g. isolation and culture), and disease pathology.

  10. Nuclear methods in environmental and energy research

    SciTech Connect

    Vogt, J R

    1980-01-01

    A total of 75 papers were presented on nuclear methods for analysis of environmental and biological samples. Sessions were devoted to software and mathematical methods; nuclear methods in atmospheric and water research; nuclear and atomic methodology; nuclear methods in biology and medicine; and nuclear methods in energy research.

  11. Naturalistic Methods in Educational Research.

    ERIC Educational Resources Information Center

    Hatch, J. Amos

    This paper describes data gathering and analytic procedures, and then presents examples regarding how each fits into the naturalistic research model. From the interactionist perspective, called symbolic interactionism, meaning is of central importance. Naturalistic inquiry is a way of doing social science research which provides the methodological…

  12. Using Qualitative Research Methods in Higher Education

    ERIC Educational Resources Information Center

    Savenye, Wilhelmina C.; Robinson, Rhonda S.

    2005-01-01

    Researchers investigating issues related to computing in higher education are increasingly using qualitative research methods to conduct their investigations. However, they may have little training or experience in qualitative research. The purpose of this paper is to introduce researchers to the appropriate use of qualitative methods. It begins…

  13. Action Research Methods: Plain and Simple

    ERIC Educational Resources Information Center

    Klein, Sheri R., Ed.

    2012-01-01

    Among the plethora of action research books on the market, there is no one text exclusively devoted to understanding how to acquire and interpret research data. Action Research Methods provides a balanced overview of the quantitative and qualitative methodologies and methods for conducting action research within a variety of educational…

  14. Recent advances in optical measurement methods in physics and chemistry

    SciTech Connect

    Gerardo, J.B.

    1985-01-01

    Progress being made in the development of new scientific measurement tools based on optics and the scientific advances made possible by these new tools is impressive. In some instances, new optical-based measurement methods have made new scientific studies possible, while in other instances they have offered an improved method for performing these studies, e.g., better signal-to-noise ratio, increased data acquisition rate, remote analysis, reduced perturbation to the physical or chemical system being studied, etc. Many of these advances were made possible by advances in laser technology - spectral purity, spectral brightness, tunability, ultrashort pulse width, amplitude stability, etc. - while others were made possible by improved optical components - single-made fibers, modulators, detectors, wavelength multiplexes, etc. Attention is limited to just a few of many such accomplishments made recently at Sandia. 17 references, 16 figures.

  15. Recent advances in research on Crimean-Congo hemorrhagic fever

    PubMed Central

    Papa, Anna; Mirazimi, Ali; Köksal, Iftihar; Estrada-Pena, Augustin; Feldmann, Heinz

    2014-01-01

    Crimean-Congo hemorrhagic fever (CCHF) is an expanding tick-borne hemorrhagic disease with increasing human and animal health impact. Immense knowledge was gained over the past 10 years mainly due to advances in molecular biology, but also driven by an increased global interest in CCHFV as an emerging/re-emerging zoonotic pathogen. In the present article we discuss the advances in research with focus on CCHF ecology, epidemiology, pathogenesis, diagnostics, prophylaxis and treatment. Despite tremendous achievements, future activities have to concentrate on the development of vaccines and antivirals/therapeutics to combat CCHF. Vector studies need to continue for better public and animal health preparedness and response. We conclude with a roadmap for future research priorities. PMID:25453328

  16. [Economic perspectives of the research on advanced therapies].

    PubMed

    Pamo Larrauri, Jose María

    2014-11-03

    Since a new advanced therapy medicinal product is discovered until finally allowed its sale in the domestic market, it has to overcome a series of stages. Biomedical research is the first phase, currently its situation is encouraging to the increase in the number of clinical trials in Spain and in the rest of the world, despite the economic situation and the various difficulties that have faced the pharmaceutical laboratories. The next phase consists in obtaining the authorization of marketing of the European Medicines Agency. After authorization, will attempt to set a fair and moderate price for inclusion in the list of health provision of Social Security. A price for a drug that provides added value to health and society, a price that is generated profits for the pharmaceutical companies that hope to make up for the years of work and investment. Commitment to advanced therapy must be clear and forceful, to fund ongoing research projects and encouraging their creation with economic aid.

  17. Magnetohydrodynamics Accelerator Research into Advanced Hypersonics (MARIAH). Part 2

    NASA Technical Reports Server (NTRS)

    Baughman, Jack A.; Micheletti, David A.; Nelson, Gordon L.; Simmons, Gloyd A.

    1997-01-01

    This report documents the activities, results, conclusions and recommendations of the Magnetohydrodynamics Accelerator Research Into Advanced Hypersonics (MARIAH) Project in which the use of magnetohydrodynamics (MHD) technology is investigated for its applicability to augment hypersonic wind tunnels. The long range objective of this investigation is to advance the development of ground test facilities to support the development of hypervelocity flight vehicles. The MHD accelerator adds kinetic energy directly to the wind tunnel working fluid, thereby increasing its Mach number to hypervelocity levels. Several techniques for MHD augmentation, as well as other physical characteristics of the process are studied to enhance the overall performance of hypersonic wind tunnel design. Specific recommendations are presented to improve the effectiveness of ground test facilities. The work contained herein builds on nearly four decades of research and experimentation by the aeronautics ground test and evaluation community, both foreign and domestic.

  18. Magnetohydrodynamics Accelerator Research Into Advanced Hypersonics (MARIAH). Part 1

    NASA Technical Reports Server (NTRS)

    Micheletti, David A.; Baughman, Jack A.; Nelson, Gordon L.; Simmons, Gloyd A.

    1997-01-01

    This report documents the activities, results, conclusions and recommendations of the Magnetohydrodynamics Accelerator Research Into Advanced Hypersonics (MARIAH) Project in which the use of magnetohydrodynamics (MHD) technology is investigated for its applicability to augment hypersonic wind tunnels. The long range objective of this investigation is to advance the development of ground test facilities to support the development of hypervelocity flight vehicles. The MHD accelerator adds kinetic energy directly to the wind tunnel working fluid, thereby increasing its Mach number to hypervelocity levels. Several techniques for MHD augmentation, as well as other physical characteristics of the process are studied to enhance the overall performance of hypersonic wind tunnel design. Specific recommendations are presented to improve the effectiveness of ground test facilities. The work contained herein builds on nearly four decades of research and experimentation by the aeronautics ground test and evaluation community, both foreign and domestic.

  19. Development and application of a probabilistic evaluation method for advanced process technologies. Final report

    SciTech Connect

    Frey, H.C.; Rubin, E.S.

    1991-04-01

    The objective of this work is to develop and apply a method for research planning for advanced process technologies. To satisfy requirements for research planning, it is necessary to: (1) identify robust solutions to process design questions in the face of uncertainty to eliminate inferior design options; (2) identify key problem areas in a technology that should be the focus of further research to reduce the risk of technology failure; (3) compare competing technologies on a consistent basis to determine the risks associated with adopting a new technology; and (4) evaluate the effects that additional research might have on comparisons with conventional technology. An important class of process technologies are electric power plants. In particular, advanced clean coal technologies are expected to play a key role in the energy and environmental future of the US, as well as in other countries. Research planning for advanced clean coal technology development is an important part of energy and environmental policy. Thus, the research planning method developed here is applied to case studies focusing on a specific clean coal technology. The purpose of the case studies is both to demonstrate the research planning method and to obtain technology-specific conclusions regarding research strategies.

  20. Development and application of a probabilistic evaluation method for advanced process technologies

    SciTech Connect

    Frey, H.C.; Rubin, E.S.

    1991-04-01

    The objective of this work is to develop and apply a method for research planning for advanced process technologies. To satisfy requirements for research planning, it is necessary to: (1) identify robust solutions to process design questions in the face of uncertainty to eliminate inferior design options; (2) identify key problem areas in a technology that should be the focus of further research to reduce the risk of technology failure; (3) compare competing technologies on a consistent basis to determine the risks associated with adopting a new technology; and (4) evaluate the effects that additional research might have on comparisons with conventional technology. An important class of process technologies are electric power plants. In particular, advanced clean coal technologies are expected to play a key role in the energy and environmental future of the US, as well as in other countries. Research planning for advanced clean coal technology development is an important part of energy and environmental policy. Thus, the research planning method developed here is applied to case studies focusing on a specific clean coal technology. The purpose of the case studies is both to demonstrate the research planning method and to obtain technology-specific conclusions regarding research strategies.

  1. Collaboration in Research and Engineering for Advanced Technology.

    SciTech Connect

    Vrieling, P. Douglas

    2016-01-01

    SNL/CA proposes the Collaboration in Research and Engineering for Advanced Technology and Education (CREATE) facility to support customer-driven national security mission requirements while demonstrating a fiscally responsible approach to cost-control. SNL/CA realizes that due to the current backlog of capital projects in NNSA that following the normal Line Item process to procure capital funding is unlikely and therefore SNL/CA will be looking at all options including Alternative Financing.

  2. Langley Research Center contributions in advancing active control technology

    NASA Technical Reports Server (NTRS)

    Abel, I.; Newsom, J. R.

    1981-01-01

    The application of active control technology to reduce aeroelastic response of aircraft structures offers a potential for significant payoffs in terms of aerodynamic efficiency and weight savings. Some of the contributions of the Langley Research Center in advancing active control technology are described. Contributions are categorized into the development of appropriate analysis tools, control law synthesis methodology, and experimental investigations aimed at verifying both analysis and synthesis methodology.

  3. Fossil Energy Advanced Research and Technology Development Materials Program

    SciTech Connect

    Cole, N.C.; Judkins, R.R.

    1992-12-01

    Objective of this materials program is to conduct R and D on materials for fossil energy applications with focus on longer-term and generic needs of the various fossil fuel technologies. The projects are organized according to materials research areas: (1) ceramics, (2) new alloys: iron aluminides, advanced austenitics and chromium niobium alloys, and (3) technology development and transfer. Separate abstracts have been prepared.

  4. 7 CFR 27.92 - Method of payment; advance deposit.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Method of payment; advance deposit. 27.92 Section 27.92 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND STANDARD...

  5. METHODS ADVANCEMENT FOR MILK ANALYSIS: THE MAMA STUDY

    EPA Science Inventory

    The Methods Advancement for Milk Analysis (MAMA) study was designed by US EPA and CDC investigators to provide data to support the technological and study design needs of the proposed National Children=s Study (NCS). The NCS is a multi-Agency-sponsored study, authorized under the...

  6. Applications of Advanced Experimental Methodologies to AWAVS Training Research. Final Report, May 1977-July 1978.

    ERIC Educational Resources Information Center

    Simon, Charles W.

    A major part of the Naval Training Equipment Center's Aviation Wide Angle Visual System (AWAVS) program involves behavioral research to provide a basis for establishing design criteria for flight trainers. As part of the task of defining the purpose and approach of this program, the applications of advanced experimental methods are explained and…

  7. Lights, Camera, Action: Advancing Learning, Research, and Program Evaluation through Video Production in Educational Leadership Preparation

    ERIC Educational Resources Information Center

    Friend, Jennifer; Militello, Matthew

    2015-01-01

    This article analyzes specific uses of digital video production in the field of educational leadership preparation, advancing a three-part framework that includes the use of video in (a) teaching and learning, (b) research methods, and (c) program evaluation and service to the profession. The first category within the framework examines videos…

  8. Advanced propulsion for LEO-Moon transport. 1: A method for evaluating advanced propulsion performance

    NASA Technical Reports Server (NTRS)

    Stern, Martin O.

    1992-01-01

    This report describes a study to evaluate the benefits of advanced propulsion technologies for transporting materials between low Earth orbit and the Moon. A relatively conventional reference transportation system, and several other systems, each of which includes one advanced technology component, are compared in terms of how well they perform a chosen mission objective. The evaluation method is based on a pairwise life-cycle cost comparison of each of the advanced systems with the reference system. Somewhat novel and economically important features of the procedure are the inclusion not only of mass payback ratios based on Earth launch costs, but also of repair and capital acquisition costs, and of adjustments in the latter to reflect the technological maturity of the advanced technologies. The required input information is developed by panels of experts. The overall scope and approach of the study are presented in the introduction. The bulk of the paper describes the evaluation method; the reference system and an advanced transportation system, including a spinning tether in an eccentric Earth orbit, are used to illustrate it.

  9. Advanced High-Level Waste Glass Research and Development Plan

    SciTech Connect

    Peeler, David K.; Vienna, John D.; Schweiger, Michael J.; Fox, Kevin M.

    2015-07-01

    The U.S. Department of Energy Office of River Protection (ORP) has implemented an integrated program to increase the loading of Hanford tank wastes in glass while meeting melter lifetime expectancies and process, regulatory, and product quality requirements. The integrated ORP program is focused on providing a technical, science-based foundation from which key decisions can be made regarding the successful operation of the Hanford Tank Waste Treatment and Immobilization Plant (WTP) facilities. The fundamental data stemming from this program will support development of advanced glass formulations, key process control models, and tactical processing strategies to ensure safe and successful operations for both the low-activity waste (LAW) and high-level waste (HLW) vitrification facilities with an appreciation toward reducing overall mission life. The purpose of this advanced HLW glass research and development plan is to identify the near-, mid-, and longer-term research and development activities required to develop and validate advanced HLW glasses and their associated models to support facility operations at WTP, including both direct feed and full pretreatment flowsheets. This plan also integrates technical support of facility operations and waste qualification activities to show the interdependence of these activities with the advanced waste glass (AWG) program to support the full WTP mission. Figure ES-1 shows these key ORP programmatic activities and their interfaces with both WTP facility operations and qualification needs. The plan is a living document that will be updated to reflect key advancements and mission strategy changes. The research outlined here is motivated by the potential for substantial economic benefits (e.g., significant increases in waste throughput and reductions in glass volumes) that will be realized when advancements in glass formulation continue and models supporting facility operations are implemented. Developing and applying advanced

  10. Recent advances in research on climate and human conflict

    NASA Astrophysics Data System (ADS)

    Hsiang, S. M.

    2014-12-01

    A rapidly growing body of empirical, quantitative research examines whether rates of human conflict can be systematically altered by climatic changes. We discuss recent advances in this field, including Bayesian meta-analyses of the effect of temperature and rainfall on current and future large-scale conflicts, the impact of climate variables on gang violence and suicides in Mexico, and probabilistic projections of personal violence and property crime in the United States under RCP scenarios. Criticisms of this research field will also be explained and addressed.

  11. Advancing Research to Action in Global Child Mental Health.

    PubMed

    Ordóñez, Anna E; Collins, Pamela Y

    2015-10-01

    Most mental and substance use disorders begin during childhood and adolescence and are the leading cause of disability in this population. Prenatal and postnatal genetic, familial, social, and environmental exposures interact to influence risk for mental disorders and trajectories of cognitive development. Efforts to advance prevention and implement early interventions to reduce the burden of mental disorders require a global research workforce, intersectoral cooperation, attention to environmental contexts, and the development and testing of evidence-based interventions. The authors describe challenges and resources for building mental health research capacity that stands to influence children's mental health outcomes around the globe.

  12. Technological advances in mucositis research: new insights and new issues.

    PubMed

    Gibson, Rachel J; Bowen, Joanne M; Keefe, Dorothy M K

    2008-08-01

    The last decade has seen a significant acceleration in the introduction of molecular tools used in cancer diagnosis and treatment. Driving factors have been the movement of advanced technologies from the laboratory to the clinic and the shift to a more genetically individualised patient approach. With this has followed an increased ability to study the toxic side effects of cancer treatment, some of which are newly emerging, by utilising many of the same technologies. Mucositis research in particular has reached a golden period of investigation and understanding of the pathobiological mechanisms that contribute to the development of the condition. This paper has selected a few of the emerging technologies that are highly relevant to mucositis research to discuss in detail. These technologies include target therapies, toxicogenomics, nanomedicine, pharmacogenetics and pharmacogenomics, with a particular focus on microarray technology. These technologies are critical to discuss in the context of mucositis research not only because they are widely applicable to cutting edge research, but they also provide opportunities for further advances both in the laboratory and clinical setting. In addition, some of these technologies have the potential to be implemented immediately in the field of mucositis research.

  13. NIDR--40 years of research advances in dental health.

    PubMed

    Sheridan, P G

    1988-01-01

    The National Institute of Dental Research (NIDR) was created by President Harry S Truman on June 24, 1948, as the third of the National Institutes of Health. NIDR's legislation contained the mandate to conduct research and research training to improve oral health. An impetus for federally funded dental research was the finding in World War II that the major cause of rejection for military service was missing teeth. Because of the population's widespread tooth decay problems, early NIDR research focused on eliminating dental caries. NIDR scientists confirmed the safety and effectiveness of the use of fluoride in tooth decay prevention, leading to one of the nation's most successful public health efforts, community water fluoridation. During the past 40 years, NIDR scientists have provided research advances and fostered technologies which changed the philosophy and practice of dentistry and brought dental sciences into the mainstream of biomedical research. Dental researchers contribute to studies of such diseases and problems as AIDS, cancer, arthritis, cystic fibrosis, diabetes, herpes, craniofacial anomalies, pain, and bone and joint disorders. NIDR's 40th anniversary in 1988 recognizes its continuing commitment to oral disease prevention and health research, and to achieving the goal of people maintaining their natural dentition for a lifetime.

  14. NIDR--40 years of research advances in dental health.

    PubMed Central

    Sheridan, P G

    1988-01-01

    The National Institute of Dental Research (NIDR) was created by President Harry S Truman on June 24, 1948, as the third of the National Institutes of Health. NIDR's legislation contained the mandate to conduct research and research training to improve oral health. An impetus for federally funded dental research was the finding in World War II that the major cause of rejection for military service was missing teeth. Because of the population's widespread tooth decay problems, early NIDR research focused on eliminating dental caries. NIDR scientists confirmed the safety and effectiveness of the use of fluoride in tooth decay prevention, leading to one of the nation's most successful public health efforts, community water fluoridation. During the past 40 years, NIDR scientists have provided research advances and fostered technologies which changed the philosophy and practice of dentistry and brought dental sciences into the mainstream of biomedical research. Dental researchers contribute to studies of such diseases and problems as AIDS, cancer, arthritis, cystic fibrosis, diabetes, herpes, craniofacial anomalies, pain, and bone and joint disorders. NIDR's 40th anniversary in 1988 recognizes its continuing commitment to oral disease prevention and health research, and to achieving the goal of people maintaining their natural dentition for a lifetime. Images p495-a p495-b p496-a p496-b p497-a p497-b p498-a PMID:3140276

  15. Conceptual frameworks and methods for advancing invasion ecology.

    PubMed

    Heger, Tina; Pahl, Anna T; Botta-Dukát, Zoltan; Gherardi, Francesca; Hoppe, Christina; Hoste, Ivan; Jax, Kurt; Lindström, Leena; Boets, Pieter; Haider, Sylvia; Kollmann, Johannes; Wittmann, Meike J; Jeschke, Jonathan M

    2013-09-01

    Invasion ecology has much advanced since its early beginnings. Nevertheless, explanation, prediction, and management of biological invasions remain difficult. We argue that progress in invasion research can be accelerated by, first, pointing out difficulties this field is currently facing and, second, looking for measures to overcome them. We see basic and applied research in invasion ecology confronted with difficulties arising from (A) societal issues, e.g., disparate perceptions of invasive species; (B) the peculiarity of the invasion process, e.g., its complexity and context dependency; and (C) the scientific methodology, e.g., imprecise hypotheses. To overcome these difficulties, we propose three key measures: (1) a checklist for definitions to encourage explicit definitions; (2) implementation of a hierarchy of hypotheses (HoH), where general hypotheses branch into specific and precisely testable hypotheses; and (3) platforms for improved communication. These measures may significantly increase conceptual clarity and enhance communication, thus advancing invasion ecology.

  16. Advancing Aeronautics: A Decision Framework for Selecting Research Agendas

    NASA Technical Reports Server (NTRS)

    Anton, Philip S.; Ecola, Liisa; Kallimani, James G.; Light, Thomas; Ohlandt, Chad J. R.; Osburg, Jan; Raman, Raj; Grammich, Clifford A.

    2011-01-01

    Publicly funded research has long played a role in the development of aeronautics, ranging from foundational research on airfoils to development of the air-traffic control system. Yet more than a century after the research and development of successful controlled, sustained, heavier-than-air flight vehicles, there are questions over the future of aeronautics research. The field of aeronautics is relatively mature, technological developments within it have become more evolutionary, and funding decisions are sometimes motivated by the continued pursuit of these evolutionary research tracks rather than by larger factors. These developments raise questions over whether public funding of aeronautics research continues to be appropriate or necessary and at what levels. Tightened federal budgets and increasing calls to address other public demands make these questions sharper still. To help it address the questions of appropriate directions for publicly funded aeronautics research, the National Aeronautics and Space Administration's (NASA's) Aeronautics Research Mission Directorate (ARMD) asked the RAND Corporation to assess the elements required to develop a strategic view of aeronautics research opportunities; identify candidate aeronautic grand challenges, paradigms, and concepts; outline a framework for evaluating them; and exercise the framework as an example of how to use it. Accordingly, this research seeks to address these questions: What aeronautics research should be supported by the U.S. government? What compelling and desirable benefits drive government-supported research? How should the government--especially NASA--make decisions about which research to support? Advancing aeronautics involves broad policy and decisionmaking challenges. Decisions involve tradeoffs among competing perspectives, uncertainties, and informed judgment.

  17. The advanced neutron source research and development plan

    SciTech Connect

    Selby, D.L.

    1995-08-01

    The Advanced Neutron Source (ANS) is being designed as a user-oriented neutron research laboratory centered around the most intense continuous beams of thermal and subthermal neutrons in the world (an order of magnitude more intense than beams available from the most advanced existing reactors). The ANS will be built around a new research reactor of 330-MW fission power, producing an unprecedented peak thermal flux of >7 {center_dot} 10{sup 19} {center_dot} m{sup -2} {center_dot} s{sup -1}. Primarily a research facility, the ANS will accommodate more than 1000 academic, industrial, and government researchers each year. They will conduct basic research in all branches of science as well as applied research leading to better understanding of new materials, including high temperature super conductors, plastics, and thin films. Some 48 neutron beam stations will be set up in the ANS beam rooms and the neutron guide hall for neutron scattering and for fundamental and nuclear physics research. There also will be extensive facilities for materials irradiation, isotope production, and analytical chemistry. The top level work breakdown structure (WBS) for the project. As noted in this figure, one component of the project is a research and development (R&D) program (WBS 1.1). This program interfaces with all of the other project level two WBS activities. Because one of the project guidelines is to meet minimum performance goals without relying on new inventions, this R&D activity is not intended to produce new concepts to allow the project to meet minimum performance goals. Instead, the R&D program will focus on the four objectives described.

  18. Advances of vibrational spectroscopic methods in phytomics and bioanalysis.

    PubMed

    Huck, Christian W

    2014-01-01

    During the last couple of years great advances in vibrational spectroscopy including near-infrared (NIR), mid-infrared (MIR), attenuated total reflection (ATR) and imaging and also mapping techniques could be achieved. On the other hand spectral treatment features have improved dramatically allowing filtering out relevant information from spectral data much more efficiently and providing new insights into the biochemical composition. These advances offer new possible quality control strategies in phytomics and enable to get deeper insights into biochemical background in terms of medicinal relevant questions. It is the aim of the present article pointing out the technical and methodological advancements in the NIR and MIR field and to demonstrate the individual methods efficiency by discussing distinct selected applications.

  19. An advanced probabilistic structural analysis method for implicit performance functions

    NASA Technical Reports Server (NTRS)

    Wu, Y.-T.; Millwater, H. R.; Cruse, T. A.

    1989-01-01

    In probabilistic structural analysis, the performance or response functions usually are implicitly defined and must be solved by numerical analysis methods such as finite element methods. In such cases, the most commonly used probabilistic analysis tool is the mean-based, second-moment method which provides only the first two statistical moments. This paper presents a generalized advanced mean value (AMV) method which is capable of establishing the distributions to provide additional information for reliability design. The method requires slightly more computations than the second-moment method but is highly efficient relative to the other alternative methods. In particular, the examples show that the AMV method can be used to solve problems involving non-monotonic functions that result in truncated distributions.

  20. Research Methods and Data Analysis Procedures Used by Educational Researchers

    ERIC Educational Resources Information Center

    Hsu, Tse-chi

    2005-01-01

    To assess the status and the trends of subject matters investigated and research methods/designs and data analysis procedures employed by educational researchers, this study surveyed articles published by the "American Educational Research Journal (AERJ)," "Journal of Experimental Education (JEE)" and "Journal of Educational Research (JER)" from…

  1. Advanced Radioisotope Power Conversion Technology Research and Development

    NASA Technical Reports Server (NTRS)

    Wong, Wayne A.

    2004-01-01

    NASA's Radioisotope Power Conversion Technology program is developing next generation power conversion technologies that will enable future missions that have requirements that cannot be met by either the ubiquitous photovoltaic systems or by current Radioisotope Power System (RPS) technology. Performance goals of advanced radioisotope power systems include improvement over the state-of-practice General Purpose Heat Source/Radioisotope Thermoelectric Generator by providing significantly higher efficiency to reduce the number of radioisotope fuel modules, and increase specific power (watts/kilogram). Other Advanced RPS goals include safety, long-life, reliability, scalability, multi-mission capability, resistance to radiation, and minimal interference with the scientific payload. NASA has awarded ten contracts in the technology areas of Brayton, Stirling, Thermoelectric, and Thermophotovoltaic power conversion including five development contracts that deal with more mature technologies and five research contracts. The Advanced RPS Systems Assessment Team includes members from NASA GRC, JPL, DOE and Orbital Sciences whose function is to review the technologies being developed under the ten Radioisotope Power Conversion Technology contracts and assess their relevance to NASA's future missions. Presented is an overview of the ten radioisotope power conversion technology contracts and NASA's Advanced RPS Systems Assessment Team.

  2. Advanced Test Reactor National Scientific User Facility: Addressing advanced nuclear materials research

    SciTech Connect

    John Jackson; Todd Allen; Frances Marshall; Jim Cole

    2013-03-01

    The Advanced Test Reactor National Scientific User Facility (ATR NSUF), based at the Idaho National Laboratory in the United States, is supporting Department of Energy and industry research efforts to ensure the properties of materials in light water reactors are well understood. The ATR NSUF is providing this support through three main efforts: establishing unique infrastructure necessary to conduct research on highly radioactive materials, conducting research in conjunction with industry partners on life extension relevant topics, and providing training courses to encourage more U.S. researchers to understand and address LWR materials issues. In 2010 and 2011, several advanced instruments with capability focused on resolving nuclear material performance issues through analysis on the micro (10-6 m) to atomic (10-10 m) scales were installed primarily at the Center for Advanced Energy Studies (CAES) in Idaho Falls, Idaho. These instruments included a local electrode atom probe (LEAP), a field-emission gun scanning transmission electron microscope (FEG-STEM), a focused ion beam (FIB) system, a Raman spectrometer, and an nanoindentor/atomic force microscope. Ongoing capability enhancements intended to support industry efforts include completion of two shielded, irradiation assisted stress corrosion cracking (IASCC) test loops, the first of which will come online in early calendar year 2013, a pressurized and controlled chemistry water loop for the ATR center flux trap, and a dedicated facility intended to house post irradiation examination equipment. In addition to capability enhancements at the main site in Idaho, the ATR NSUF also welcomed two new partner facilities in 2011 and two new partner facilities in 2012; the Oak Ridge National Laboratory, High Flux Isotope Reactor (HFIR) and associated hot cells and the University California Berkeley capabilities in irradiated materials analysis were added in 2011. In 2012, Purdue University’s Interaction of Materials

  3. Advances in nucleic acid-based detection methods.

    PubMed Central

    Wolcott, M J

    1992-01-01

    Laboratory techniques based on nucleic acid methods have increased in popularity over the last decade with clinical microbiologists and other laboratory scientists who are concerned with the diagnosis of infectious agents. This increase in popularity is a result primarily of advances made in nucleic acid amplification and detection techniques. Polymerase chain reaction, the original nucleic acid amplification technique, changed the way many people viewed and used nucleic acid techniques in clinical settings. After the potential of polymerase chain reaction became apparent, other methods of nucleic acid amplification and detection were developed. These alternative nucleic acid amplification methods may become serious contenders for application to routine laboratory analyses. This review presents some background information on nucleic acid analyses that might be used in clinical and anatomical laboratories and describes some recent advances in the amplification and detection of nucleic acids. PMID:1423216

  4. Fracture Toughness in Advanced Monolithic Ceramics - SEPB Versus SEVENB Methods

    NASA Technical Reports Server (NTRS)

    Choi, S. R.; Gyekenyesi, J. P.

    2005-01-01

    Fracture toughness of a total of 13 advanced monolithic ceramics including silicon nitrides, silicon carbide, aluminas, and glass ceramic was determined at ambient temperature by using both single edge precracked beam (SEPB) and single edge v-notched beam (SEVNB) methods. Relatively good agreement in fracture toughness between the two methods was observed for advanced ceramics with flat R-curves; whereas, poor agreement in fracture toughness was seen for materials with rising R-curves. The discrepancy in fracture toughness between the two methods was due to stable crack growth with crack closure forces acting in the wake region of cracks even in SEVNB test specimens. The effect of discrepancy in fracture toughness was analyzed in terms of microstructural feature (grain size and shape), toughening exponent, and stable crack growth determined using back-face strain gaging.

  5. Facing up to the Challenges of Advancing Craniofacial Research

    PubMed Central

    Trainor, Paul A.; Richtsmeier, Joan T.

    2015-01-01

    Craniofacial anomalies are among the most common human birth defects and have considerable functional, aesthetic, and social consequences. The early developmental origin as well as the anatomical complexity of the head and face render these tissues prone to genetic and environmental insult. The establishment of craniofacial clinics offering comprehensive care for craniofacial patients at a single site together with international research networks focused on the origins and treatment of craniofacial disorders has led to tremendous advances in our understanding of the etiology and pathogenesis of congenital craniofacial anomalies. However, the genetic, environmental, and developmental sources of many craniofacial disorders remain unknown. To overcome this problem and further advance craniofacial research, we must recognize current challenges in the field and establish priority areas for study. We still need (i) a deeper understanding of variation during normal development and within the context of any disorder, (ii) improved genotyping and phenotyping and understanding of the impact of epigenetics, (iii) continued development of animal models and functional analyses of genes and variants, and (iv) integration of patient derived cells and tissues together with 3D printing and quantitative assessment of surgical outcomes for improved practice. Only with fundamental advances in each of these areas will we be able to meet the challenge of translating potential therapeutic and preventative approaches into clinical solutions and reduce the financial and emotional burden of craniofacial anomalies. PMID:25820983

  6. Facing up to the challenges of advancing Craniofacial Research.

    PubMed

    Trainor, Paul A; Richtsmeier, Joan T

    2015-07-01

    Craniofacial anomalies are among the most common human birth defects and have considerable functional, aesthetic, and social consequences. The early developmental origin as well as the anatomical complexity of the head and face render these tissues prone to genetic and environmental insult. The establishment of craniofacial clinics offering comprehensive care for craniofacial patients at a single site together with international research networks focused on the origins and treatment of craniofacial disorders has led to tremendous advances in our understanding of the etiology and pathogenesis of congenital craniofacial anomalies. However, the genetic, environmental, and developmental sources of many craniofacial disorders remain unknown. To overcome this problem and further advance craniofacial research, we must recognize current challenges in the field and establish priority areas for study. We still need (i) a deeper understanding of variation during normal development and within the context of any disorder, (ii) improved genotyping and phenotyping and understanding of the impact of epigenetics, (iii) continued development of animal models and functional analyses of genes and variants, and (iv) integration of patient derived cells and tissues together with 3D printing and quantitative assessment of surgical outcomes for improved practice. Only with fundamental advances in each of these areas will we be able to meet the challenge of translating potential therapeutic and preventative approaches into clinical solutions and reduce the financial and emotional burden of craniofacial anomalies.

  7. Simulated Interactive Research Experiments as Educational Tools for Advanced Science

    NASA Astrophysics Data System (ADS)

    Tomandl, Mathias; Mieling, Thomas; Losert-Valiente Kroon, Christiane M.; Hopf, Martin; Arndt, Markus

    2015-09-01

    Experimental research has become complex and thus a challenge to science education. Only very few students can typically be trained on advanced scientific equipment. It is therefore important to find new tools that allow all students to acquire laboratory skills individually and independent of where they are located. In a design-based research process we have investigated the feasibility of using a virtual laboratory as a photo-realistic and scientifically valid representation of advanced scientific infrastructure to teach modern experimental science, here, molecular quantum optics. We found a concept based on three educational principles that allows undergraduate students to become acquainted with procedures and concepts of a modern research field. We find a significant increase in student understanding using our Simulated Interactive Research Experiment (SiReX), by evaluating the learning outcomes with semi-structured interviews in a pre/post design. This suggests that this concept of an educational tool can be generalized to disseminate findings in other fields.

  8. Simulated Interactive Research Experiments as Educational Tools for Advanced Science.

    PubMed

    Tomandl, Mathias; Mieling, Thomas; Losert-Valiente Kroon, Christiane M; Hopf, Martin; Arndt, Markus

    2015-09-15

    Experimental research has become complex and thus a challenge to science education. Only very few students can typically be trained on advanced scientific equipment. It is therefore important to find new tools that allow all students to acquire laboratory skills individually and independent of where they are located. In a design-based research process we have investigated the feasibility of using a virtual laboratory as a photo-realistic and scientifically valid representation of advanced scientific infrastructure to teach modern experimental science, here, molecular quantum optics. We found a concept based on three educational principles that allows undergraduate students to become acquainted with procedures and concepts of a modern research field. We find a significant increase in student understanding using our Simulated Interactive Research Experiment (SiReX), by evaluating the learning outcomes with semi-structured interviews in a pre/post design. This suggests that this concept of an educational tool can be generalized to disseminate findings in other fields.

  9. Simulated Interactive Research Experiments as Educational Tools for Advanced Science

    PubMed Central

    Tomandl, Mathias; Mieling, Thomas; Losert-Valiente Kroon, Christiane M.; Hopf, Martin; Arndt, Markus

    2015-01-01

    Experimental research has become complex and thus a challenge to science education. Only very few students can typically be trained on advanced scientific equipment. It is therefore important to find new tools that allow all students to acquire laboratory skills individually and independent of where they are located. In a design-based research process we have investigated the feasibility of using a virtual laboratory as a photo-realistic and scientifically valid representation of advanced scientific infrastructure to teach modern experimental science, here, molecular quantum optics. We found a concept based on three educational principles that allows undergraduate students to become acquainted with procedures and concepts of a modern research field. We find a significant increase in student understanding using our Simulated Interactive Research Experiment (SiReX), by evaluating the learning outcomes with semi-structured interviews in a pre/post design. This suggests that this concept of an educational tool can be generalized to disseminate findings in other fields. PMID:26370627

  10. Mixed Methods Approaches in Family Science Research

    ERIC Educational Resources Information Center

    Plano Clark, Vicki L.; Huddleston-Casas, Catherine A.; Churchill, Susan L.; Green, Denise O'Neil; Garrett, Amanda L.

    2008-01-01

    The complex phenomena of interest to family scientists require the use of quantitative and qualitative approaches. Researchers across the social sciences are now turning to mixed methods designs that combine these two approaches. Mixed methods research has great promise for addressing family science topics, but only if researchers understand the…

  11. EarthCube Activities: Community Engagement Advancing Geoscience Research

    NASA Astrophysics Data System (ADS)

    Kinkade, D.

    2015-12-01

    Our ability to advance scientific research in order to better understand complex Earth systems, address emerging geoscience problems, and meet societal challenges is increasingly dependent upon the concept of Open Science and Data. Although these terms are relatively new to the world of research, Open Science and Data in this context may be described as transparency in the scientific process. This includes the discoverability, public accessibility and reusability of scientific data, as well as accessibility and transparency of scientific communication (www.openscience.org). Scientists and the US government alike are realizing the critical need for easy discovery and access to multidisciplinary data to advance research in the geosciences. The NSF-supported EarthCube project was created to meet this need. EarthCube is developing a community-driven common cyberinfrastructure for the purpose of accessing, integrating, analyzing, sharing and visualizing all forms of data and related resources through advanced technological and computational capabilities. Engaging the geoscience community in EarthCube's development is crucial to its success, and EarthCube is providing several opportunities for geoscience involvement. This presentation will provide an overview of the activities EarthCube is employing to entrain the community in the development process, from governance development and strategic planning, to technical needs gathering. Particular focus will be given to the collection of science-driven use cases as a means of capturing scientific and technical requirements. Such activities inform the development of key technical and computational components that collectively will form a cyberinfrastructure to meet the research needs of the geoscience community.

  12. Multiple Methods: Research Methods in Education Projects at NSF

    ERIC Educational Resources Information Center

    Suter, Larry E.

    2005-01-01

    Projects on science and mathematics education research supported by the National Science Foundation (US government) rarely employ a single method of study. Studies of educational practices that use experimental design are very rare. The most common research method is the case study method and the second most common is some form of experimental…

  13. Los Alamos NEP research in advanced plasma thrusters

    NASA Technical Reports Server (NTRS)

    Schoenberg, Kurt; Gerwin, Richard

    1991-01-01

    Research was initiated in advanced plasma thrusters that capitalizes on lab capabilities in plasma science and technology. The goal of the program was to examine the scaling issues of magnetoplasmadynamic (MPD) thruster performance in support of NASA's MPD thruster development program. The objective was to address multi-megawatt, large scale, quasi-steady state MPD thruster performance. Results to date include a new quasi-steady state operating regime which was obtained at space exploration initiative relevant power levels, that enables direct coaxial gun-MPD comparisons of thruster physics and performance. The radiative losses are neglible. Operation with an applied axial magnetic field shows the same operational stability and exhaust plume uniformity benefits seen in MPD thrusters. Observed gun impedance is in close agreement with the magnetic Bernoulli model predictions. Spatial and temporal measurements of magnetic field, electric field, plasma density, electron temperature, and ion/neutral energy distribution are underway. Model applications to advanced mission logistics are also underway.

  14. Advances in Inner Magnetosphere Passive and Active Wave Research

    NASA Technical Reports Server (NTRS)

    Green, James L.; Fung, Shing F.

    2004-01-01

    This review identifies a number of the principal research advancements that have occurred over the last five years in the study of electromagnetic (EM) waves in the Earth's inner magnetosphere. The observations used in this study are from the plasma wave instruments and radio sounders on Cluster, IMAGE, Geotail, Wind, Polar, Interball, and others. The data from passive plasma wave instruments have led to a number of advances such as: determining the origin and importance of whistler mode waves in the plasmasphere, discovery of the source of kilometric continuum radiation, mapping AKR source regions with "pinpoint" accuracy, and correlating the AKR source location with dipole tilt angle. Active magnetospheric wave experiments have shown that long range ducted and direct echoes can be used to obtain the density distribution of electrons in the polar cap and along plasmaspheric field lines, providing key information on plasmaspheric filling rates and polar cap outflows.

  15. Research Dilemmas: Paradigms, Methods and Methodology

    ERIC Educational Resources Information Center

    Mackenzie, Noella; Knipe, Sally

    2006-01-01

    In this article the authors discuss issues faced by early career researchers, including the dichotomy, which many research textbooks and journal articles create and perpetuate between qualitative and quantitative research methodology despite considerable literature to support the use of mixed methods. The authors review current research literature…

  16. Recommendations for Culturally Sensitive Research Methods

    ERIC Educational Resources Information Center

    Awad, Germine H.; Patall, Erika A.; Rackley, Kadie R.; Reilly, Erin D.

    2016-01-01

    As the US continues to diversify, methods for accurately assessing human behavior must evolve. This paper offers multicultural research considerations at several stages of the research process for psychological research and consultation. Implications regarding the comparative research framework are discussed and suggestions are offered on how to…

  17. Advanced stress analysis methods applicable to turbine engine structures

    NASA Technical Reports Server (NTRS)

    Pian, Theodore H. H.

    1991-01-01

    The following tasks on the study of advanced stress analysis methods applicable to turbine engine structures are described: (1) constructions of special elements which contain traction-free circular boundaries; (2) formulation of new version of mixed variational principles and new version of hybrid stress elements; (3) establishment of methods for suppression of kinematic deformation modes; (4) construction of semiLoof plate and shell elements by assumed stress hybrid method; and (5) elastic-plastic analysis by viscoplasticity theory using the mechanical subelement model.

  18. Improved method of HIPOT testing of advanced ignition system product

    SciTech Connect

    Baker, P.C.

    1992-04-01

    A new method of high potential (HIPOT) testing of advanced ignition system (AIS) product was developed. The new incorporated using a silver-filled RTV silicone as the electrodes of the HIPOT tester instead of the preformed, semi-rigid aluminum electrodes of the current tester. Initial results indicate that the developed method was more sensitive to the testing requirements of the HIPOT test. A patent for the combination of the material used and the method of testing developed was attempted but was withdrawn following a patent search by the US Patent Office.

  19. Computational methods to extract meaning from text and advance theories of human cognition.

    PubMed

    McNamara, Danielle S

    2011-01-01

    Over the past two decades, researchers have made great advances in the area of computational methods for extracting meaning from text. This research has to a large extent been spurred by the development of latent semantic analysis (LSA), a method for extracting and representing the meaning of words using statistical computations applied to large corpora of text. Since the advent of LSA, researchers have developed and tested alternative statistical methods designed to detect and analyze meaning in text corpora. This research exemplifies how statistical models of semantics play an important role in our understanding of cognition and contribute to the field of cognitive science. Importantly, these models afford large-scale representations of human knowledge and allow researchers to explore various questions regarding knowledge, discourse processing, text comprehension, and language. This topic includes the latest progress by the leading researchers in the endeavor to go beyond LSA.

  20. Computational methods to extract meaning from text and advance theories of human cognition.

    PubMed

    McNamara, Danielle S

    2011-01-01

    Over the past two decades, researchers have made great advances in the area of computational methods for extracting meaning from text. This research has to a large extent been spurred by the development of latent semantic analysis (LSA), a method for extracting and representing the meaning of words using statistical computations applied to large corpora of text. Since the advent of LSA, researchers have developed and tested alternative statistical methods designed to detect and analyze meaning in text corpora. This research exemplifies how statistical models of semantics play an important role in our understanding of cognition and contribute to the field of cognitive science. Importantly, these models afford large-scale representations of human knowledge and allow researchers to explore various questions regarding knowledge, discourse processing, text comprehension, and language. This topic includes the latest progress by the leading researchers in the endeavor to go beyond LSA. PMID:25164173

  1. Advanced NDE research in electromagnetic, thermal, and coherent optics

    NASA Technical Reports Server (NTRS)

    Skinner, S. Ballou

    1992-01-01

    A new inspection technology called magneto-optic/eddy current imaging was investigated. The magneto-optic imager makes readily visible irregularities and inconsistencies in airframe components. Other research observed in electromagnetics included (1) disbond detection via resonant modal analysis; (2) AC magnetic field frequency dependence of magnetoacoustic emission; and (3) multi-view magneto-optic imaging. Research observed in the thermal group included (1) thermographic detection and characterization of corrosion in aircraft aluminum; (2) a multipurpose infrared imaging system for thermoelastic stress detection; (3) thermal diffusivity imaging of stress induced damage in composites; and (4) detection and measurement of ice formation on the space shuttle main fuel tank. Research observed in the optics group included advancements in optical nondestructive evaluation (NDE).

  2. Research Methods in Interlanguage Pragmatics.

    ERIC Educational Resources Information Center

    Kasper, Gabriele; Dahl, Merete

    1991-01-01

    A review of data collection methods used in 39 studies of interlanguage pragmatics, focusing on the validity of different types of data resulting from discourse completion, role play, observation of authentic speech, and multiple approaches, concludes that caution is needed in determining the true validity of the collected data. (72 references)…

  3. Assessment of Research Needs for Advanced Fuel Cells

    SciTech Connect

    Penner, S.S.

    1985-11-01

    The DOE Advanced Fuel Cell Working Group (AFCWG) was formed and asked to perform a scientific evaluation of the current status of fuel cells, with emphasis on identification of long-range research that may have a significant impact on the practical utilization of fuel cells in a variety of applications. The AFCWG held six meetings at locations throughout the country where fuel cell research and development are in progress, for presentations by experts on the status of fuel cell research and development efforts, as well as for inputs on research needs. Subsequent discussions by the AFCWG have resulted in the identification of priority research areas that should be explored over the long term in order to advance the design and performance of fuel cells of all types. Surveys describing the salient features of individual fuel cell types are presented in Chapters 2 to 6 and include elaborations of long-term research needs relating to the expeditious introduction of improved fuel cells. The Introduction and the Summary (Chapter 1) were prepared by AFCWG. They were repeatedly revised in response to comments and criticism. The present version represents the closest approach to a consensus that we were able to reach, which should not be interpreted to mean that each member of AFCWG endorses every statement and every unexpressed deletion. The Introduction and Summary always represent a majority view and, occasionally, a unanimous judgment. Chapters 2 to 6 provide background information and carry the names of identified authors. The identified authors of Chapters 2 to 6, rather than AFCWG as a whole, bear full responsibility for the scientific and technical contents of these chapters.

  4. The Delphi Method for Graduate Research

    ERIC Educational Resources Information Center

    Skulmoski, Gregory J.; Hartman, Francis T.; Krahn, Jennifer

    2007-01-01

    The Delphi method is an attractive method for graduate students completing masters and PhD level research. It is a flexible research technique that has been successfully used in our program at the University of Calgary to explore new concepts within and outside of the information systems body of knowledge. The Delphi method is an iterative process…

  5. Recent trends and advances in berry health benefits research.

    PubMed

    Seeram, Navindra P

    2010-04-14

    Recent advances have been made in our scientific understanding of how berries promote human health and prevent chronic illnesses such as some cancers, heart disease, and neurodegenerative diseases. Cancer is rapidly overtaking heart disease as the number one killer disease in developed countries, and this phenomenon is coupled with a growing aging population and concomitant age-related diseases. Therefore, it is not surprising that consumers are turning toward foods with medicinal properties as promising dietary interventions for disease prevention and health maintenance. Among fruits, berries of all colors have emerged as champions with substantial research data supporting their abilities to positively affect multiple disease states. Apart from several essential dietary components found in berries, such as vitamins, minerals, and fiber, berries also contain numerous bioactives that provide health benefits that extend beyond basic nutrition. Berry bioactives encompass a wide diversity of phytochemicals (phytonutrients) ranging from fat-soluble/lipophilic to water-soluble/hydrophilic compounds. Recent research from laboratories across the globe has provided useful insights into the biological effects and underlying mechanisms of actions resulting from eating berries. The cluster of papers included here represents a cross section of topics discussed at the 2009 International Berry Health Benefits Symposium. Together, these papers provide valuable insight into recent research trends and advances made into evaluating the various health benefits that may result from the consumption of berries and their derived products.

  6. Recent trends and advances in berry health benefits research.

    PubMed

    Seeram, Navindra P

    2010-04-14

    Recent advances have been made in our scientific understanding of how berries promote human health and prevent chronic illnesses such as some cancers, heart disease, and neurodegenerative diseases. Cancer is rapidly overtaking heart disease as the number one killer disease in developed countries, and this phenomenon is coupled with a growing aging population and concomitant age-related diseases. Therefore, it is not surprising that consumers are turning toward foods with medicinal properties as promising dietary interventions for disease prevention and health maintenance. Among fruits, berries of all colors have emerged as champions with substantial research data supporting their abilities to positively affect multiple disease states. Apart from several essential dietary components found in berries, such as vitamins, minerals, and fiber, berries also contain numerous bioactives that provide health benefits that extend beyond basic nutrition. Berry bioactives encompass a wide diversity of phytochemicals (phytonutrients) ranging from fat-soluble/lipophilic to water-soluble/hydrophilic compounds. Recent research from laboratories across the globe has provided useful insights into the biological effects and underlying mechanisms of actions resulting from eating berries. The cluster of papers included here represents a cross section of topics discussed at the 2009 International Berry Health Benefits Symposium. Together, these papers provide valuable insight into recent research trends and advances made into evaluating the various health benefits that may result from the consumption of berries and their derived products. PMID:20020687

  7. Twelfth International Symposium on Recent Advances in Environmental Health Research

    PubMed Central

    Tchounwou, Paul B.

    2016-01-01

    During the past century, environmental hazards have become a major concern, not only to public health professionals, but also to the society at large because of their tremendous health, socio-cultural and economic impacts. Various anthropogenic or natural factors have been implicated in the alteration of ecosystem integrity, as well as in the development of a wide variety of acute and/or chronic diseases in humans. It has also been demonstrated that many environmental agents, acting either independently or in combination with other toxins, may induce a wide range of adverse health outcomes. Understanding the role played by the environment in the etiology of human diseases is critical to designing cost-effective control/prevention measures. This special issue of International Journal of Environmental Research and Public Health includes the proceedings of the Twelfth International Symposium on Recent Advances in Environmental Health Research. The Symposium provided an excellent opportunity to discuss the scientific advances in biomedical, environmental, and public health research that addresses global environmental health issues. PMID:27153079

  8. Twelfth International Symposium on Recent Advances in Environmental Health Research.

    PubMed

    Tchounwou, Paul B

    2016-05-04

    During the past century, environmental hazards have become a major concern, not only to public health professionals, but also to the society at large because of their tremendous health, socio-cultural and economic impacts. Various anthropogenic or natural factors have been implicated in the alteration of ecosystem integrity, as well as in the development of a wide variety of acute and/or chronic diseases in humans. It has also been demonstrated that many environmental agents, acting either independently or in combination with other toxins, may induce a wide range of adverse health outcomes. Understanding the role played by the environment in the etiology of human diseases is critical to designing cost-effective control/prevention measures. This special issue of International Journal of Environmental Research and Public Health includes the proceedings of the Twelfth International Symposium on Recent Advances in Environmental Health Research. The Symposium provided an excellent opportunity to discuss the scientific advances in biomedical, environmental, and public health research that addresses global environmental health issues.

  9. The Interuniversity Programme for Advanced Management Education, Consultancy and Research

    ERIC Educational Resources Information Center

    Revans, Professor

    1969-01-01

    Since 1965, Professor Revans has been Senior Research Fellow in the European Association of Management Training Centres, specializing in the application of analytical methods to an understanding of industrial morale. (EB)

  10. Oklahoma State University proposed Advanced Technology Research Center. Environmental Assessment

    SciTech Connect

    1995-06-01

    The Department of Energy (DOE) has prepared an Environmental Assessment (EA) evaluating the construction and equipping of the proposed Advanced Technology Research Center (ATRC) at Oklahoma State University (OSU) in Stillwater, Oklahoma. Based on the analysis in the EA, the DOE has determined that the proposed action does not constitute a major federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act (NEPA) of 1969. Therefore, the preparation of an Environmental Impact Statement is not required.

  11. [Advances in the research of treatment of hydrofluoric acid burn].

    PubMed

    Wang, Xin-gang; Zhang, Yuan-hai; Han, Chun-mao

    2013-08-01

    Hydrofluoric acid (HF) is one of the most common inorganic acids used widely in industrial circle. HF not only causes cutaneous burn, but also induces systemic toxicity by its unique injury mechanism. Accurate and timely diagnosis and treatment are critical after HF burns. To date, the strategies for treating HF burns have been developed, mainly including topical treatments and systematic support. However, there is no standard treatment strategy with wide acceptance in the world. This paper presents a comprehensive overview of the advances in the research of strategies for the treatment of HF burns.

  12. 76 FR 52954 - Workshop: Advancing Research on Mixtures; New Perspectives and Approaches for Predicting Adverse...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Workshop: Advancing Research on Mixtures; New Perspectives and Approaches for Predicting... ``Advancing Research on Mixtures: New Perspectives and Approaches for Predicting Adverse Human Health...

  13. FAA/NASA International Symposium on Advanced Structural Integrity Methods for Airframe Durability and Damage Tolerance

    NASA Technical Reports Server (NTRS)

    Harris, Charles E. (Editor)

    1994-01-01

    International technical experts in durability and damage tolerance of metallic airframe structures were assembled to present and discuss recent research findings and the development of advanced design and analysis methods, structural concepts, and advanced materials. The symposium focused on the dissemination of new knowledge and the peer-review of progress on the development of advanced methodologies. Papers were presented on: structural concepts for enhanced durability, damage tolerance, and maintainability; new metallic alloys and processing technology; fatigue crack initiation and small crack effects; fatigue crack growth models; fracture mechanics failure, criteria for ductile materials; structural mechanics methodology for residual strength and life prediction; development of flight load spectra for design and testing; and advanced approaches to resist corrosion and environmentally assisted fatigue.

  14. Research investigations in oil shale, tar sand, coal research, advanced exploratory process technology, and advanced fuels research: Volume 2 -- Jointly sponsored research program. Final report, October 1986--September 1993

    SciTech Connect

    Smith, V.E.

    1994-09-01

    Numerous studies have been conducted in five principal areas: oil shale, tar sand, underground coal gasification, advanced process technology, and advanced fuels research. In subsequent years, underground coal gasification was broadened to be coal research, under which several research activities were conducted that related to coal processing. The most significant change occurred in 1989 when the agreement was redefined as a Base Program and a Jointly Sponsored Research Program (JSRP). Investigations were conducted under the Base Program to determine the physical and chemical properties of materials suitable for conversion to liquid and gaseous fuels, to test and evaluate processes and innovative concepts for such conversions, to monitor and determine environmental impacts related to development of commercial-sized operations, and to evaluate methods for mitigation of potential environmental impacts. This report is divided into two volumes: Volume 1 consists of 28 summaries that describe the principal research efforts conducted under the Base Program in five topic areas. Volume 2 describes tasks performed within the JSRP. Research conducted under this agreement has resulted in technology transfer of a variety of energy-related research information. A listing of related publications and presentations is given at the end of each research topic summary. More specific and detailed information is provided in the topical reports referenced in the related publications listings.

  15. Advanced Stirling Technology Development at NASA Glenn Research Center

    NASA Technical Reports Server (NTRS)

    Shaltens, Richard K.; Wong, Wayne A.

    2007-01-01

    The NASA Glenn Research Center has been developing advanced energy-conversion technologies for use with both radioisotope power systems and fission surface power systems for many decades. Under NASA's Science Mission Directorate, Planetary Science Theme, Technology Program, Glenn is developing the next generation of advanced Stirling convertors (ASCs) for use in the Department of Energy/Lockheed Martin Advanced Stirling Radioisotope Generator (ASRG). The next-generation power-conversion technologies require high efficiency and high specific power (watts electric per kilogram) to meet future mission requirements to use less of the Department of Energy's plutonium-fueled general-purpose heat source modules and reduce system mass. Important goals include long-life (greater than 14-yr) reliability and scalability so that these systems can be considered for a variety of future applications and missions including outer-planet missions and continual operation on the surface of Mars. This paper provides an update of the history and status of the ASC being developed for Glenn by Sunpower Inc. of Athens, Ohio.

  16. Major clinical research advances in gynecologic cancer in 2015

    PubMed Central

    2016-01-01

    In 2015, fourteen topics were selected as major research advances in gynecologic oncology. For ovarian cancer, high-level evidence for annual screening with multimodal strategy which could reduce ovarian cancer deaths was reported. The best preventive strategies with current status of evidence level were also summarized. Final report of chemotherapy or upfront surgery (CHORUS) trial of neoadjuvant chemotherapy in advanced stage ovarian cancer and individualized therapy based on gene characteristics followed. There was no sign of abating in great interest in immunotherapy as well as targeted therapies in various gynecologic cancers. The fifth Ovarian Cancer Consensus Conference which was held in November 7–9 in Tokyo was briefly introduced. For cervical cancer, update of human papillomavirus vaccines regarding two-dose regimen, 9-valent vaccine, and therapeutic vaccine was reviewed. For corpus cancer, the safety concern of power morcellation in presumed fibroids was explored again with regard to age and prevalence of corpus malignancy. Hormone therapy and endometrial cancer risk, trabectedin as an option for leiomyosarcoma, endometrial cancer and Lynch syndrome, and the radiation therapy guidelines were also discussed. In addition, adjuvant therapy in vulvar cancer and the updated of targeted therapy in gynecologic cancer were addressed. For breast cancer, palbociclib in hormone-receptor-positive advanced disease, oncotype DX Recurrence Score in low-risk patients, regional nodal irradiation to internal mammary, supraclavicular, and axillary lymph nodes, and cavity shave margins were summarized as the last topics covered in this review. PMID:27775259

  17. Qualitative methods in environmental health research.

    PubMed Central

    Brown, Phil

    2003-01-01

    Public health researchers increasingly turn to qualitative methods either on their own or in combination with quantitative methods. Qualitative methods are especially important to community environmental health research, as they provide a way to produce community narratives that give voice to individuals and characterize the community in a full and complex fashion. This article first traces the legacy of qualitative research in environmental health, then uses a case study of the author's experiences studying the Woburn, Massachusetts, childhood leukemia cluster to provide personal and scholarly insights on qualitative approaches. That material then informs a discussion of important components of qualitative methods in environmental health research, including flexible study design, access, trust, empathy, and personal shifts in the researcher's worldview, bias, and the nature of the researcher's roles. A concluding discussion addresses issues in funding policy and research practices. PMID:14594634

  18. Integrating Research Skills Training into Non--Research Methods Courses

    ERIC Educational Resources Information Center

    Woolf, Jules

    2014-01-01

    Research skills are a valued commodity by industry and university administrators. Despite the importance placed on these skills students typically dislike taking research method courses where these skills are learned. However, training in research skills does not necessarily have to be confined to these courses. In this study participants at a…

  19. [Internet research methods: advantages and challenges].

    PubMed

    Liu, Yi; Tien, Yueh-Hsuan

    2009-12-01

    Compared to traditional research methods, using the Internet to conduct research offers a number of advantages to the researcher, which include increased access to sensitive issues and vulnerable / hidden populations; decreased data entry time requirements; and enhanced data accuracy. However, Internet research also presents certain challenges to the researcher. In this article, the advantages and challenges of Internet research methods are discussed in four principle issue areas: (a) recruitment, (b) data quality, (c) practicality, and (d) ethics. Nursing researchers can overcome problems related to sampling bias and data truthfulness using creative methods; resolve technical problems through collaboration with other disciplines; and protect participant's privacy, confidentiality and data security by maintaining a high level of vigilance. Once such issues have been satisfactorily addressed, the Internet should open a new window for Taiwan nursing research.

  20. Regeneration of tissues of the oral complex: current clinical trends and research advances.

    PubMed

    Nguyen, Thomas T; Mui, Brennan; Mehrabzadeh, Mahsa; Chea, Yannie; Chaudhry, Zoya; Chaudhry, Kamran; Tran, Simon D

    2013-01-01

    Regenerative therapy in oral health care is limited by both the body's natural capacity for regeneration and the materials and methods currently available. Research on various aspects of regenerative therapy, such as tissue engineering and stem cell and gene therapy, has produced promising results. Compelling advances, ranging from the discovery and characterization of stem cell populations in oral tissue to the engineering and transplantation of whole tooth structures, could result in exciting new treatment methods for clinicians in the near future. In this review, we discuss the limitations of natural healing and regeneration of various tissues of the oral complex, including teeth, periodontium and salivary glands, and summarize current treatment methods for tissue damage as well as research advances in oral tissue regeneration.

  1. Origins, Methods and Advances in Qualitative Meta-Synthesis

    ERIC Educational Resources Information Center

    Nye, Elizabeth; Melendez-Torres, G. J.; Bonell, Chris

    2016-01-01

    Qualitative research is a broad term encompassing many methods. Critiques of the field of qualitative research argue that while individual studies provide rich descriptions and insights, the absence of connections drawn between studies limits their usefulness. In response, qualitative meta-synthesis serves as a design to interpret and synthesise…

  2. [Research advances on anaerobic ferrous-oxidizing microorganisms].

    PubMed

    Zhang, Meng; Zheng, Ping; Ji, Jun-yuan

    2013-08-01

    Anaerobic ferrous-oxidizing microorganisms (AFOM) are one of the important discoveries in microbiology, geology and environmental science. The study of AFOM is of significance to make clear the banded iron formations (BIFs), promote the biogeochemical cycles of iron, nitrogen and carbon, enrich the microbiological content, develop new biotechnologies for anaerobic iron oxidation, and explore the ancient earth environment and extraterrestrial life. This paper summarized the research advances on AFOM, introduced the habitats of AFOM, discussed the biodiversity and the nutritive and metabolic characteristics of AFOM, and assessed the potential functions of AFOM. An outlook was made on the future researches of new species AFOM, their microbial metabolism mechanisms, and their development and applications. PMID:24380362

  3. PREFACE: 7th EEIGM International Conference on Advanced Materials Research

    NASA Astrophysics Data System (ADS)

    Joffe, Roberts

    2013-12-01

    The 7th EEIGM Conference on Advanced Materials Research (AMR 2013) was held at Luleå University of Technology on the 21-22 March 2013 in Luleå, SWEDEN. This conference is intended as a meeting place for researchers involved in the EEIGM programme, in the 'Erasmus Mundus' Advanced Materials Science and Engineering Master programme (AMASE) and the 'Erasmus Mundus' Doctoral Programme in Materials Science and Engineering (DocMASE). This is great opportunity to present their on-going research in the various fields of Materials Science and Engineering, exchange ideas, strengthen co-operation as well as establish new contacts. More than 60 participants representing six countries attended the meeting, in total 26 oral talks and 19 posters were presented during two days. This issue of IOP Conference Series: Materials Science and Engineering presents a selection of articles from EEIGM-7 conference. Following tradition from previous EEIGM conferences, it represents the interdisciplinary nature of Materials Science and Engineering. The papers presented in this issue deal not only with basic research but also with applied problems of materials science. The presented topics include theoretical and experimental investigations on polymer composite materials (synthetic and bio-based), metallic materials and ceramics, as well as nano-materials of different kind. Special thanks should be directed to the senior staff of Division of Materials Science at LTU who agreed to review submitted papers and thus ensured high scientific level of content of this collection of papers. The following colleagues participated in the review process: Professor Lennart Walström, Professor Roberts Joffe, Professor Janis Varna, Associate Professor Marta-Lena Antti, Dr Esa Vuorinen, Professor Aji Mathew, Professor Alexander Soldatov, Dr Andrejs Purpurs, Dr Yvonne Aitomäki, Dr Robert Pederson. Roberts Joffe October 2013, Luleå Conference photograph EEIGM7 conference participants, 22 March 2013 The PDF

  4. [Economic perspectives of the research on advanced therapies].

    PubMed

    Pamo Larrauri, Jose María

    2014-01-01

    Since a new advanced therapy medicinal product is discovered until finally allowed its sale in the domestic market, it has to overcome a series of stages. Biomedical research is the first phase, currently its situation is encouraging to the increase in the number of clinical trials in Spain and in the rest of the world, despite the economic situation and the various difficulties that have faced the pharmaceutical laboratories. The next phase consists in obtaining the authorization of marketing of the European Medicines Agency. After authorization, will attempt to set a fair and moderate price for inclusion in the list of health provision of Social Security. A price for a drug that provides added value to health and society, a price that is generated profits for the pharmaceutical companies that hope to make up for the years of work and investment. Commitment to advanced therapy must be clear and forceful, to fund ongoing research projects and encouraging their creation with economic aid. PMID:25542659

  5. Developing more open and equitable relationships with industry to improve advancements in clinical research in dermatology.

    PubMed

    Campa, M; Ryan, C; Menter, A

    2016-06-01

    Relationships between physicians, scientists, and the pharmaceutical industry can be complicated by conflicts of interest. Honest and equitable relationships, however, are essential to the advancement of dermatologic clinical research. Several factors can increase transparency in clinical trials including preregistration of clinical trials, reporting of all data produced from clinical trials, non-industry ownership of clinical trial data, clarity of statistical methods and publication of both positive and negative results. Through collaborative, scientifically rigorous studies, physicians and industry can achieve significant advances in dermatologic care. PMID:27317287

  6. Area Reports. Advanced materials and devices research area. Silicon materials research task, and advanced silicon sheet task

    NASA Technical Reports Server (NTRS)

    1986-01-01

    The objectives of the Silicon Materials Task and the Advanced Silicon Sheet Task are to identify the critical technical barriers to low-cost silicon purification and sheet growth that must be overcome to produce a PV cell substrate material at a price consistent with Flat-plate Solar Array (FSA) Project objectives and to overcome these barriers by performing and supporting appropriate R&D. Progress reports are given on silicon refinement using silane, a chemical vapor transport process for purifying metallurgical grade silicon, silicon particle growth research, and modeling of silane pyrolysis in fluidized-bed reactors.

  7. Developing Phenomenological Method for Researching Lesbian Existence.

    ERIC Educational Resources Information Center

    Hunnisett, Rowena J.

    1986-01-01

    Argues a complementary relationship between phenomenological method and feminist theory, then develops a research method suited to the study of lesbians in their communities. A comparison of three phenomenological methods produces one new method with methodological innovations in interviewing, mapping, and data analysis. Findings of the study…

  8. e-Learning Business Research Methods

    ERIC Educational Resources Information Center

    Cowie, Jonathan

    2004-01-01

    This paper outlines the development of a generic Business Research Methods course from a simple name in a box to a full e-Learning web based module. It highlights particular issues surrounding the nature of the discipline and the integration of a large number of cross faculty subject specific research methods courses into a single generic module.…

  9. The Advanced Neutron Source research and development plan

    SciTech Connect

    Selby, D.L.

    1992-11-30

    The Advanced Neutron Source (ANS) is being designed as a user-oriented neutron research laboratory centered around the most intense continuous beams of thermal and subthermal neutrons in the world. The ANS will be built around a new research reactor of {approximately} 330 MW fission power, producing an unprecedented peak thermal flux of > 7 {times} 10{sup 19} M{sup {minus}2} {center_dot} S{sup {minus}1}. Primarily a research facility, the ANS will accommodate more than 1000 academic, industrial, and government researchers each year. They will conduct basic research in all branches of science-as well as applied research-leading to better understanding of new materials, including high temperature super conductors, plastics, and thin films. Some 48 neutron beam stations will be set up in the ANS beam rooms and the neutron guide hall for neutron scattering and for fundamental and nuclear physics research. There also will be extensive facilities for materials irradiation, isotope production, and analytical chemistry. The R&D program will focus on the four objectives: Address feasibility issues; provide analysis support; evaluate options for improvement in performance beyond minimum requirements; and provide prototype demonstrations for unique facilities. The remainder of this report presents (1) the process by which the R&D activities are controlled and (2) a discussion of the individual tasks that have been identified for the R&D program, including their justification, schedule and costs. The activities discussed in this report will be performed by Martin Marietta Energy Systems, Inc. (MMES) through the Oak Ridge National Laboratory (ORNL) and through subcontracts with industry, universities, and other national laboratories. It should be noted that in general a success path has been assumed for all tasks.

  10. The Advanced Neutron Source research and development plan

    SciTech Connect

    Selby, D.L.

    1992-11-30

    The Advanced Neutron Source (ANS) is being designed as a user-oriented neutron research laboratory centered around the most intense continuous beams of thermal and subthermal neutrons in the world. The ANS will be built around a new research reactor of [approximately] 330 MW fission power, producing an unprecedented peak thermal flux of > 7 [times] 10[sup 19] M[sup [minus]2] [center dot] S[sup [minus]1]. Primarily a research facility, the ANS will accommodate more than 1000 academic, industrial, and government researchers each year. They will conduct basic research in all branches of science-as well as applied research-leading to better understanding of new materials, including high temperature super conductors, plastics, and thin films. Some 48 neutron beam stations will be set up in the ANS beam rooms and the neutron guide hall for neutron scattering and for fundamental and nuclear physics research. There also will be extensive facilities for materials irradiation, isotope production, and analytical chemistry. The R D program will focus on the four objectives: Address feasibility issues; provide analysis support; evaluate options for improvement in performance beyond minimum requirements; and provide prototype demonstrations for unique facilities. The remainder of this report presents (1) the process by which the R D activities are controlled and (2) a discussion of the individual tasks that have been identified for the R D program, including their justification, schedule and costs. The activities discussed in this report will be performed by Martin Marietta Energy Systems, Inc. (MMES) through the Oak Ridge National Laboratory (ORNL) and through subcontracts with industry, universities, and other national laboratories. It should be noted that in general a success path has been assumed for all tasks.

  11. Using observational methods in nursing research.

    PubMed

    Salmon, Jenny

    2015-07-01

    Observation is a research data-collection method used generally to capture the activities of participants as well as when and where things are happening in a given setting. It checks description of the phenomena against what the researcher perceives to be fact in a rich experiential context. The method's main strength is that it provides direct access to the social phenomena under consideration. It can be used quantitatively or qualitatively, depending on the research question. Challenges in using observation relate to adopting the role of participant or non-participant researcher as observer. This article discusses some of the complexities involved when nurse researchers seek to collect observational data on social processes in naturalistic settings using unstructured or structured observational methods in qualitative research methodology. A glossary of research terms is provided.

  12. [Nonpoint source pollution in Northeast China: research advance].

    PubMed

    Yang, Yu-Hong; Yan, Bai-Xing

    2010-03-01

    In order to understand the research trend on nonpoint source (NPS) pollution in Northeast China and to find its problems and shortcomings, the related research findings from 1991 to 2008 were searched, categorized, and statistically analyzed, so that the regional strategies could be employed to bring water pollution under control. Overall, the research on NPS pollution in Northeast China had an increasing trend, and the research contents included investigation and assessment, quantification of pollution load, mechanisms of pollutants translocation, modeling simulation, and prevention and control. The research interests were nitrogen, phosphorus, sediments, pesticides, and heavy metals. Empirical methods rather than mechanism models were more used to estimate the pollution load, and the researches were more on agricultural rather than urban NPS pollution. The control and management of NPS pollution was remained in soil and water conservation, and lacked of optimal collection assessment for soil and water conservation measures and of assessment for optimal management methods. At present, the research was overall at the stage of theoretical exploration, and controversy remained whether the nonpoint source was major source or not. Incoming researches should focus on the measure application, assessment, basic data collection, determination of regional NPS pollutants, quantification of pollution load, and invention of new technologies; and multi-disciplinary corporation should be strengthened to supply scientific bases for regional water environmental control and prevention.

  13. [Nonpoint source pollution in Northeast China: research advance].

    PubMed

    Yang, Yu-Hong; Yan, Bai-Xing

    2010-03-01

    In order to understand the research trend on nonpoint source (NPS) pollution in Northeast China and to find its problems and shortcomings, the related research findings from 1991 to 2008 were searched, categorized, and statistically analyzed, so that the regional strategies could be employed to bring water pollution under control. Overall, the research on NPS pollution in Northeast China had an increasing trend, and the research contents included investigation and assessment, quantification of pollution load, mechanisms of pollutants translocation, modeling simulation, and prevention and control. The research interests were nitrogen, phosphorus, sediments, pesticides, and heavy metals. Empirical methods rather than mechanism models were more used to estimate the pollution load, and the researches were more on agricultural rather than urban NPS pollution. The control and management of NPS pollution was remained in soil and water conservation, and lacked of optimal collection assessment for soil and water conservation measures and of assessment for optimal management methods. At present, the research was overall at the stage of theoretical exploration, and controversy remained whether the nonpoint source was major source or not. Incoming researches should focus on the measure application, assessment, basic data collection, determination of regional NPS pollutants, quantification of pollution load, and invention of new technologies; and multi-disciplinary corporation should be strengthened to supply scientific bases for regional water environmental control and prevention. PMID:20560338

  14. Future directions of C3 research at DARPA (Defense Advanced Research Projects Agency)

    NASA Astrophysics Data System (ADS)

    Perry, D. G.; Dahmann, J. S.

    Research into C3 related problems is a major effort of the Information Science and Technology Office of the Defense Advanced Research Projects Agency. The major thrusts of projects are in the area of future, high-risk efforts, often resulting in the development of a conceptual model or prototype. Some of these prototypes are then further developed to provide an infrastructure for future research. The programs can be divided into two groups: base technology research programs and testbed programs. The testbeds provide a focus for the technology programs.

  15. [Advances in cancer research. Cancer research and clinical oncology in the 21st century].

    PubMed

    Kanamaru, R

    1999-06-01

    It is my great pleasure to congradulate the Japanese Journal of Cancer and Chemotherapy on its 25 th anniversary. During this period, great progress has been made in cancer research, mainly owing to the advances in technology in molecular biology. Recently, not only researchers, but lay people as well have come to understand that cancer is mainly a genetic disease. Advances in the human genome project, DNA chip technology and gene technology; including gene targeting and cloning techniques, will enable us to accelerate progress forward the final goal of cancer research in the coming century. Major changes are coming in both cancer research and clinical oncology, which will completely transform the human social environment.

  16. Innovative methods in soil phosphorus research: A review

    PubMed Central

    Kruse, Jens; Abraham, Marion; Amelung, Wulf; Baum, Christel; Bol, Roland; Kühn, Oliver; Lewandowski, Hans; Niederberger, Jörg; Oelmann, Yvonne; Rüger, Christopher; Santner, Jakob; Siebers, Meike; Siebers, Nina; Spohn, Marie; Vestergren, Johan; Vogts, Angela; Leinweber, Peter

    2015-01-01

    Phosphorus (P) is an indispensable element for all life on Earth and, during the past decade, concerns about the future of its global supply have stimulated much research on soil P and method development. This review provides an overview of advanced state-of-the-art methods currently used in soil P research. These involve bulk and spatially resolved spectroscopic and spectrometric P speciation methods (1 and 2D NMR, IR, Raman, Q-TOF MS/MS, high resolution-MS, NanoSIMS, XRF, XPS, (µ)XAS) as well as methods for assessing soil P reactions (sorption isotherms, quantum-chemical modeling, microbial biomass P, enzymes activity, DGT, 33P isotopic exchange, 18O isotope ratios). Required experimental set-ups and the potentials and limitations of individual methods present a guide for the selection of most suitable methods or combinations. PMID:26167132

  17. Advanced parallel programming models research and development opportunities.

    SciTech Connect

    Wen, Zhaofang.; Brightwell, Ronald Brian

    2004-07-01

    There is currently a large research and development effort within the high-performance computing community on advanced parallel programming models. This research can potentially have an impact on parallel applications, system software, and computing architectures in the next several years. Given Sandia's expertise and unique perspective in these areas, particularly on very large-scale systems, there are many areas in which Sandia can contribute to this effort. This technical report provides a survey of past and present parallel programming model research projects and provides a detailed description of the Partitioned Global Address Space (PGAS) programming model. The PGAS model may offer several improvements over the traditional distributed memory message passing model, which is the dominant model currently being used at Sandia. This technical report discusses these potential benefits and outlines specific areas where Sandia's expertise could contribute to current research activities. In particular, we describe several projects in the areas of high-performance networking, operating systems and parallel runtime systems, compilers, application development, and performance evaluation.

  18. Advancing cancer control research in an emerging news media environment.

    PubMed

    Smith, Katherine C; Niederdeppe, Jeff; Blake, Kelly D; Cappella, Joseph N

    2013-12-01

    Cancer is both highly feared and highly newsworthy, and there is a robust body of research documenting the content and effects of cancer news coverage on health behaviors and policy. Recent years have witnessed ongoing, transformative shifts in American journalism alongside rapid advances in communication technology and the public information environment. These changes create a pressing need to consider a new set of research questions, sampling strategies, measurement techniques, and theories of media effects to ensure continued relevance and adaptation of communication research to address critical cancer control concerns. This paper begins by briefly reviewing what we know about the role of cancer news in shaping cancer-related beliefs, attitudes, behaviors, and policies. We then outline challenges and opportunities, both theoretical and methodological, posed by the rapidly changing news media environment and the nature of audience engagement. We organize our discussion around three major shifts associated with the emerging news media environment as it relates to health communication: 1) speed and dynamism of news diffusion, 2) increased narrowcasting of media content for specialized audiences, and 3) broadened participation in shaping media content. In so doing, we articulate a set of questions for future theory and research, in an effort to catalyze innovative communication scholarship to improve cancer prevention and control. PMID:24395988

  19. Mixed Method Designs in Implementation Research

    PubMed Central

    Aarons, Gregory A.; Horwitz, Sarah; Chamberlain, Patricia; Hurlburt, Michael; Landsverk, John

    2010-01-01

    This paper describes the application of mixed method designs in implementation research in 22 mental health services research studies published in peer-reviewed journals over the last 5 years. Our analyses revealed 7 different structural arrangements of qualitative and quantitative methods, 5 different functions of mixed methods, and 3 different ways of linking quantitative and qualitative data together. Complexity of design was associated with number of aims or objectives, study context, and phase of implementation examined. The findings provide suggestions for the use of mixed method designs in implementation research. PMID:20967495

  20. Qualitative versus quantitative methods in psychiatric research.

    PubMed

    Razafsha, Mahdi; Behforuzi, Hura; Azari, Hassan; Zhang, Zhiqun; Wang, Kevin K; Kobeissy, Firas H; Gold, Mark S

    2012-01-01

    Qualitative studies are gaining their credibility after a period of being misinterpreted as "not being quantitative." Qualitative method is a broad umbrella term for research methodologies that describe and explain individuals' experiences, behaviors, interactions, and social contexts. In-depth interview, focus groups, and participant observation are among the qualitative methods of inquiry commonly used in psychiatry. Researchers measure the frequency of occurring events using quantitative methods; however, qualitative methods provide a broader understanding and a more thorough reasoning behind the event. Hence, it is considered to be of special importance in psychiatry. Besides hypothesis generation in earlier phases of the research, qualitative methods can be employed in questionnaire design, diagnostic criteria establishment, feasibility studies, as well as studies of attitude and beliefs. Animal models are another area that qualitative methods can be employed, especially when naturalistic observation of animal behavior is important. However, since qualitative results can be researcher's own view, they need to be statistically confirmed, quantitative methods. The tendency to combine both qualitative and quantitative methods as complementary methods has emerged over recent years. By applying both methods of research, scientists can take advantage of interpretative characteristics of qualitative methods as well as experimental dimensions of quantitative methods.

  1. The benefits of basic research: advances in reproductive physiology.

    PubMed

    1995-06-01

    At the Population Council's Center for Biomedical Research basic research is being conducted on the reproductive system with a view to develop new contraceptive and reproductive health technologies. Research in the Reproductive Physiology Program at the Center is carried out by reproductive endocrinologists, molecular biologists, and biochemists working in eight laboratories. In several of the laboratories the function of hormones that regulate spermatogenesis is studied. Scientists in Milan Bagchi's laboratory have developed a model system, composed of cellular components in a test tube, that allows them to study the full sequence of events involved in signal transduction. In James Catterall's laboratory, scientists study how androgens regulate sexual development at the molecular level. The steroid hormones cortisol and corticosterone play critical roles in mammalian fetal development. Scientists in several laboratories study the function of two specialized testicular cells: the Leydig and Sertoli cells. The Leydig cell synthesizes and secretes testosterone, an androgen that regulates spermatogenesis. The Sertoli cell maintains the environment in which spermatogenesis occurs. Researchers in Glen Gunsalus's laboratory study an androgen-binding protein secreted by the Sertoli cell. In collaboration with scientists at the Shanghai Research Center of Biotechnology, they used advanced genetic techniques to create a biologically active form of the protein in silk worm larvae. Scientists in Patricia Morris's laboratory recently identified molecular signals that control the interactions between developing sperm and Sertoli and Leydig cells. In the laboratory of David Phillips, scientists are investigating how the HIV virus penetrates the outer layer of cells in the genital tract and infects underlying cells. In 1994 a vaginally applied microbicide was developed that may inhibit infection by sexually transmitted diseases including HIV. Applications of basic research such

  2. Novel glass inspection method for advanced photomask blanks

    NASA Astrophysics Data System (ADS)

    Tanabe, Masaru; Kikuchi, Toshiharu; Hashimoto, Masahiro; Ohkubo, Yasushi

    2007-05-01

    Recently, extremely-high-quality-quartz substrates have been demanded for advancing ArF-lithography. HOYA has developed a novel inspection method for interior defects as well as surface defects. The total internal reflection of the substrate is employed to produce an ideal dark field illumination. The novel inspection method can detect a "nano-pit" of 12nm-EDS, the Equivalent of the Diameter of a Sphere (EDS). It will meet the sensitivity for 32nm node and beyond. Moreover, a type of unique defect is detected, which induces Serious Transmittance Error for Arf-LiTHography. We call it the "STEALTH" defect. It is a killer defect in wafer printing; but it cannot be detected with any conventional inspection in the mask-making process so far. In this paper, the performance of the novel inspection method for quartz substrates and the investigation of "STEALTH" are reported.

  3. Advanced reactor physics methods for heterogeneous reactor cores

    NASA Astrophysics Data System (ADS)

    Thompson, Steven A.

    To maintain the economic viability of nuclear power the industry has begun to emphasize maximizing the efficiency and output of existing nuclear power plants by using longer fuel cycles, stretch power uprates, shorter outage lengths, mixed-oxide (MOX) fuel and more aggressive operating strategies. In order to accommodate these changes, while still satisfying the peaking factor and power envelope requirements necessary to maintain safe operation, more complexity in commercial core designs have been implemented, such as an increase in the number of sub-batches and an increase in the use of both discrete and integral burnable poisons. A consequence of the increased complexity of core designs, as well as the use of MOX fuel, is an increase in the neutronic heterogeneity of the core. Such heterogeneous cores introduce challenges for the current methods that are used for reactor analysis. New methods must be developed to address these deficiencies while still maintaining the computational efficiency of existing reactor analysis methods. In this thesis, advanced core design methodologies are developed to be able to adequately analyze the highly heterogeneous core designs which are currently in use in commercial power reactors. These methodological improvements are being pursued with the goal of not sacrificing the computational efficiency which core designers require. More specifically, the PSU nodal code NEM is being updated to include an SP3 solution option, an advanced transverse leakage option, and a semi-analytical NEM solution option.

  4. Healthy ageing, narrative method and research ethics.

    PubMed

    Sarvimäki, Anneli

    2015-08-01

    The purpose of this article is to describe research and teaching activities related to healthy ageing, narrative methods and research ethics at the Nordic School of Public Health NHV during 1999 - 2012. Healthy ageing was conceived in terms of The World Health Organization's (WHO) model of active ageing and of quality of life defined as a sense of well-being, meaning and value. Qualitative research on ageing and health conducted at NHV showed how elderly people themselves experience health and what they perceive to be health promoting. Narrative method was one the qualitative methods used in research at NHV. By adopting holistic and categorical content analysis the life stories of elderly Finnish migrants, the stories of home-dwelling persons about falls, and working persons' stories of alcohol use were studied. The courses on research ethics took their point of departure in a model that describes the role of scientific, economic, aesthetic and ethical values in research.

  5. High speed research system study. Advanced flight deck configuration effects

    NASA Technical Reports Server (NTRS)

    Swink, Jay R.; Goins, Richard T.

    1992-01-01

    In mid-1991 NASA contracted with industry to study the high-speed civil transport (HSCT) flight deck challenges and assess the benefits, prior to initiating their High Speed Research Program (HSRP) Phase 2 efforts, then scheduled for FY-93. The results of this nine-month effort are presented, and a number of the most significant findings for the specified advanced concepts are highlighted: (1) a no nose-droop configuration; (2) a far forward cockpit location; and (3) advanced crew monitoring and control of complex systems. The results indicate that the no nose-droop configuration is critically dependent upon the design and development of a safe, reliable, and certifiable Synthetic Vision System (SVS). The droop-nose configuration would cause significant weight, performance, and cost penalties. The far forward cockpit location, with the conventional side-by-side seating provides little economic advantage; however, a configuration with a tandem seating arrangement provides a substantial increase in either additional payload (i.e., passengers) or potential downsizing of the vehicle with resulting increases in performance efficiencies and associated reductions in emissions. Without a droop nose, forward external visibility is negated and takeoff/landing guidance and control must rely on the use of the SVS. The technologies enabling such capabilities, which de facto provides for Category 3 all-weather operations on every flight independent of weather, represent a dramatic benefits multiplier in a 2005 global ATM network: both in terms of enhanced economic viability and environmental acceptability.

  6. Recent Advances in Research on Widow Spider Venoms and Toxins.

    PubMed

    Yan, Shuai; Wang, Xianchun

    2015-11-27

    Widow spiders have received much attention due to the frequently reported human and animal injures caused by them. Elucidation of the molecular composition and action mechanism of the venoms and toxins has vast implications in the treatment of latrodectism and in the neurobiology and pharmaceutical research. In recent years, the studies of the widow spider venoms and the venom toxins, particularly the α-latrotoxin, have achieved many new advances; however, the mechanism of action of the venom toxins has not been completely clear. The widow spider is different from many other venomous animals in that it has toxic components not only in the venom glands but also in other parts of the adult spider body, newborn spiderlings, and even the eggs. More recently, the molecular basis for the toxicity outside the venom glands has been systematically investigated, with four proteinaceous toxic components being purified and preliminarily characterized, which has expanded our understanding of the widow spider toxins. This review presents a glance at the recent advances in the study on the venoms and toxins from the Latrodectus species.

  7. Recent Advances in Research on Widow Spider Venoms and Toxins

    PubMed Central

    Yan, Shuai; Wang, Xianchun

    2015-01-01

    Widow spiders have received much attention due to the frequently reported human and animal injures caused by them. Elucidation of the molecular composition and action mechanism of the venoms and toxins has vast implications in the treatment of latrodectism and in the neurobiology and pharmaceutical research. In recent years, the studies of the widow spider venoms and the venom toxins, particularly the α-latrotoxin, have achieved many new advances; however, the mechanism of action of the venom toxins has not been completely clear. The widow spider is different from many other venomous animals in that it has toxic components not only in the venom glands but also in other parts of the adult spider body, newborn spiderlings, and even the eggs. More recently, the molecular basis for the toxicity outside the venom glands has been systematically investigated, with four proteinaceous toxic components being purified and preliminarily characterized, which has expanded our understanding of the widow spider toxins. This review presents a glance at the recent advances in the study on the venoms and toxins from the Latrodectus species. PMID:26633495

  8. Advanced Stirling Convertor Testing at NASA Glenn Research Center

    NASA Technical Reports Server (NTRS)

    Oriti, Salvatore M.; Blaze, Gina M.

    2007-01-01

    The U.S. Department of Energy (DOE), Lockheed Martin Space Systems (LMSS), Sunpower Inc., and NASA Glenn Research Center (GRC) have been developing an Advanced Stirling Radioisotope Generator (ASRG) for use as a power system on space science and exploration missions. This generator will make use of the free-piston Stirling convertors to achieve higher conversion efficiency than currently available alternatives. The ASRG will utilize two Advanced Stirling Convertors (ASC) to convert thermal energy from a radioisotope heat source to electricity. NASA GRC has initiated several experiments to demonstrate the functionality of the ASC, including: in-air extended operation, thermal vacuum extended operation, and ASRG simulation for mobile applications. The in-air and thermal vacuum test articles are intended to provide convertor performance data over an extended operating time. These test articles mimic some features of the ASRG without the requirement of low system mass. Operation in thermal vacuum adds the element of simulating deep space. This test article is being used to gather convertor performance and thermal data in a relevant environment. The ASRG simulator was designed to incorporate a minimum amount of support equipment, allowing integration onto devices powered directly by the convertors, such as a rover. This paper discusses the design, fabrication, and implementation of these experiments.

  9. Launch Vehicle Design and Optimization Methods and Priority for the Advanced Engineering Environment

    NASA Technical Reports Server (NTRS)

    Rowell, Lawrence F.; Korte, John J.

    2003-01-01

    NASA's Advanced Engineering Environment (AEE) is a research and development program that will improve collaboration among design engineers for launch vehicle conceptual design and provide the infrastructure (methods and framework) necessary to enable that environment. In this paper, three major technical challenges facing the AEE program are identified, and three specific design problems are selected to demonstrate how advanced methods can improve current design activities. References are made to studies that demonstrate these design problems and methods, and these studies will provide the detailed information and check cases to support incorporation of these methods into the AEE. This paper provides background and terminology for discussing the launch vehicle conceptual design problem so that the diverse AEE user community can participate in prioritizing the AEE development effort.

  10. The neutron texture diffractometer at the China Advanced Research Reactor

    NASA Astrophysics Data System (ADS)

    Li, Mei-Juan; Liu, Xiao-Long; Liu, Yun-Tao; Tian, Geng-Fang; Gao, Jian-Bo; Yu, Zhou-Xiang; Li, Yu-Qing; Wu, Li-Qi; Yang, Lin-Feng; Sun, Kai; Wang, Hong-Li; Santisteban, J. r.; Chen, Dong-Feng

    2016-03-01

    The first neutron texture diffractometer in China has been built at the China Advanced Research Reactor, due to strong demand for texture measurement with neutrons from the domestic user community. This neutron texture diffractometer has high neutron intensity, moderate resolution and is mainly applied to study texture in commonly used industrial materials and engineering components. In this paper, the design and characteristics of this instrument are described. The results for calibration with neutrons and quantitative texture analysis of zirconium alloy plate are presented. The comparison of texture measurements with the results obtained in HIPPO at LANSCE and Kowari at ANSTO illustrates the reliability of the texture diffractometer. Supported by National Nature Science Foundation of China (11105231, 11205248, 51327902) and International Atomic Energy Agency-TC program (CPR0012)

  11. [Advances in the researches of lutein and alzheimer's disease].

    PubMed

    Xu, Xianrong; Lin, Xiaoming

    2015-05-01

    Lutein, a kind of oxycarotenoid, can pass the blood brain barrier and preferentially accumulate in the human brain, which is the most abundant carotenoid in human brain. Evidence from multiple studies suggested that lutein was closely related to age-related cognitive decline and risk of Alzheimer's disease (AD) in human. Dietary, plasma and brain concentrations of lutein were negatively associated with age-related cognitive decline. Lutein concentrations in plasma and brain were significantly lower in AD patients than those of health control. In human brain, lutein was the sole carotenoid which consistently associated with a range of cognitive function measures. In elderly women, lutein supplement can improve the cognitive function. In this article, we systematically reviewed the literature on the role of lutein in age-related cognitive decline and alzheimer's disease and its possible mechanisms. It may prove some benefit information for the advanced research and prevention of AD.

  12. Recent advances in research applications of nanophase hydroxyapatite.

    PubMed

    Fox, Kate; Tran, Phong A; Tran, Nhiem

    2012-07-16

    Hydroxyapatite, the main inorganic material in natural bone, has been used widely for orthopaedic applications. Due to size effects and surface phenomena at the nanoscale, nanophase hydroxyapatite possesses unique properties compared to its bulk-phase counterpart. The high surface-to-volume ratio, reactivities, and biomimetic morphologies make nano-hydroxyapatite more favourable in applications such as orthopaedic implant coating or bone substitute filler. Recently, more efforts have been focused on the possibility of combining hydroxyapatite with other drugs and materials for multipurpose applications, such as antimicrobial treatments, osteoporosis treatments and magnetic manipulation. To build more effective nano-hydroxyapatite and composite systems, the particle synthesis processes, chemistry, and toxicity have to be thoroughly investigated. In this Minireview, we report the recent advances in research regarding nano-hydroxyapatite. Synthesis routes and a wide range of applications of hydroxyapatite nanoparticles will be discussed. The Minireview also addresses several challenges concerning the biosafety of the nanoparticles.

  13. Invited review article: Advanced light microscopy for biological space research.

    PubMed

    De Vos, Winnok H; Beghuin, Didier; Schwarz, Christian J; Jones, David B; van Loon, Jack J W A; Bereiter-Hahn, Juergen; Stelzer, Ernst H K

    2014-10-01

    As commercial space flights have become feasible and long-term extraterrestrial missions are planned, it is imperative that the impact of space travel and the space environment on human physiology be thoroughly characterized. Scrutinizing the effects of potentially detrimental factors such as ionizing radiation and microgravity at the cellular and tissue level demands adequate visualization technology. Advanced light microscopy (ALM) is the leading tool for non-destructive structural and functional investigation of static as well as dynamic biological systems. In recent years, technological developments and advances in photochemistry and genetic engineering have boosted all aspects of resolution, readout and throughput, rendering ALM ideally suited for biological space research. While various microscopy-based studies have addressed cellular response to space-related environmental stressors, biological endpoints have typically been determined only after the mission, leaving an experimental gap that is prone to bias results. An on-board, real-time microscopical monitoring device can bridge this gap. Breadboards and even fully operational microscope setups have been conceived, but they need to be rendered more compact and versatile. Most importantly, they must allow addressing the impact of gravity, or the lack thereof, on physiologically relevant biological systems in space and in ground-based simulations. In order to delineate the essential functionalities for such a system, we have reviewed the pending questions in space science, the relevant biological model systems, and the state-of-the art in ALM. Based on a rigorous trade-off, in which we recognize the relevance of multi-cellular systems and the cellular microenvironment, we propose a compact, but flexible concept for space-related cell biological research that is based on light sheet microscopy. PMID:25362364

  14. Invited Review Article: Advanced light microscopy for biological space research

    SciTech Connect

    De Vos, Winnok H.; Beghuin, Didier; Schwarz, Christian J.; Jones, David B.; Loon, Jack J. W. A. van

    2014-10-15

    As commercial space flights have become feasible and long-term extraterrestrial missions are planned, it is imperative that the impact of space travel and the space environment on human physiology be thoroughly characterized. Scrutinizing the effects of potentially detrimental factors such as ionizing radiation and microgravity at the cellular and tissue level demands adequate visualization technology. Advanced light microscopy (ALM) is the leading tool for non-destructive structural and functional investigation of static as well as dynamic biological systems. In recent years, technological developments and advances in photochemistry and genetic engineering have boosted all aspects of resolution, readout and throughput, rendering ALM ideally suited for biological space research. While various microscopy-based studies have addressed cellular response to space-related environmental stressors, biological endpoints have typically been determined only after the mission, leaving an experimental gap that is prone to bias results. An on-board, real-time microscopical monitoring device can bridge this gap. Breadboards and even fully operational microscope setups have been conceived, but they need to be rendered more compact and versatile. Most importantly, they must allow addressing the impact of gravity, or the lack thereof, on physiologically relevant biological systems in space and in ground-based simulations. In order to delineate the essential functionalities for such a system, we have reviewed the pending questions in space science, the relevant biological model systems, and the state-of-the art in ALM. Based on a rigorous trade-off, in which we recognize the relevance of multi-cellular systems and the cellular microenvironment, we propose a compact, but flexible concept for space-related cell biological research that is based on light sheet microscopy.

  15. Invited review article: Advanced light microscopy for biological space research.

    PubMed

    De Vos, Winnok H; Beghuin, Didier; Schwarz, Christian J; Jones, David B; van Loon, Jack J W A; Bereiter-Hahn, Juergen; Stelzer, Ernst H K

    2014-10-01

    As commercial space flights have become feasible and long-term extraterrestrial missions are planned, it is imperative that the impact of space travel and the space environment on human physiology be thoroughly characterized. Scrutinizing the effects of potentially detrimental factors such as ionizing radiation and microgravity at the cellular and tissue level demands adequate visualization technology. Advanced light microscopy (ALM) is the leading tool for non-destructive structural and functional investigation of static as well as dynamic biological systems. In recent years, technological developments and advances in photochemistry and genetic engineering have boosted all aspects of resolution, readout and throughput, rendering ALM ideally suited for biological space research. While various microscopy-based studies have addressed cellular response to space-related environmental stressors, biological endpoints have typically been determined only after the mission, leaving an experimental gap that is prone to bias results. An on-board, real-time microscopical monitoring device can bridge this gap. Breadboards and even fully operational microscope setups have been conceived, but they need to be rendered more compact and versatile. Most importantly, they must allow addressing the impact of gravity, or the lack thereof, on physiologically relevant biological systems in space and in ground-based simulations. In order to delineate the essential functionalities for such a system, we have reviewed the pending questions in space science, the relevant biological model systems, and the state-of-the art in ALM. Based on a rigorous trade-off, in which we recognize the relevance of multi-cellular systems and the cellular microenvironment, we propose a compact, but flexible concept for space-related cell biological research that is based on light sheet microscopy.

  16. Invited Review Article: Advanced light microscopy for biological space research

    NASA Astrophysics Data System (ADS)

    De Vos, Winnok H.; Beghuin, Didier; Schwarz, Christian J.; Jones, David B.; van Loon, Jack J. W. A.; Bereiter-Hahn, Juergen; Stelzer, Ernst H. K.

    2014-10-01

    As commercial space flights have become feasible and long-term extraterrestrial missions are planned, it is imperative that the impact of space travel and the space environment on human physiology be thoroughly characterized. Scrutinizing the effects of potentially detrimental factors such as ionizing radiation and microgravity at the cellular and tissue level demands adequate visualization technology. Advanced light microscopy (ALM) is the leading tool for non-destructive structural and functional investigation of static as well as dynamic biological systems. In recent years, technological developments and advances in photochemistry and genetic engineering have boosted all aspects of resolution, readout and throughput, rendering ALM ideally suited for biological space research. While various microscopy-based studies have addressed cellular response to space-related environmental stressors, biological endpoints have typically been determined only after the mission, leaving an experimental gap that is prone to bias results. An on-board, real-time microscopical monitoring device can bridge this gap. Breadboards and even fully operational microscope setups have been conceived, but they need to be rendered more compact and versatile. Most importantly, they must allow addressing the impact of gravity, or the lack thereof, on physiologically relevant biological systems in space and in ground-based simulations. In order to delineate the essential functionalities for such a system, we have reviewed the pending questions in space science, the relevant biological model systems, and the state-of-the art in ALM. Based on a rigorous trade-off, in which we recognize the relevance of multi-cellular systems and the cellular microenvironment, we propose a compact, but flexible concept for space-related cell biological research that is based on light sheet microscopy.

  17. FY09 Advanced Instrumentation and Active Interrogation Research for Safeguards

    SciTech Connect

    D. L. Chichester; S. A. Pozzi; E. H. Seabury; J. L. Dolan; M. Flaska; J. T. Johnson; S. M. Watson; J. Wharton

    2009-08-01

    Multiple small-scale projects have been undertaken to investigate advanced instrumentation solutions for safeguard measurement challenges associated with advanced fuel cycle facilities and next-generation fuel reprocessing installations. These activities are in support of the U.S. Department of Energy's Fuel Cycle Research and Development program and its Materials Protection, Accounting, and Control for Transmutation (MPACT) campaign. 1) Work was performed in a collaboration with the University of Michigan (Prof. Sara Pozzi, co-PI) to investigate the use of liquid-scintillator radiation detectors for assaying mixed-oxide (MOX) fuel, to characterize its composition and to develop advanced digital pulse-shape discrimination algorithms for performing time-correlation measurements in the MOX fuel environment. This work included both simulations and experiments and has shown that these techniques may provide a valuable approach for use within advanced safeguard measurement scenarios. 2) Work was conducted in a collaboration with Oak Ridge National Laboratory (Dr. Paul Hausladen, co-PI) to evaluate the strengths and weaknesses of the fast-neutron coded-aperture imaging technique for locating and characterizing fissile material, and as a tool for performing hold-up measurements in fissile material handling facilities. This work involved experiments at Idaho National Laboratory, using MOX fuel and uranium metal, in both passive and active interrogation configurations. A complete analysis has not yet been completed but preliminary results suggest several potential uses for the fast neutron imaging technique. 3) Work was carried out to identify measurement approaches for determining nitric acid concentration in the range of 1 – 4 M and beyond. This work included laboratory measurements to investigate the suitability of prompt-gamma neutron activation analysis for this measurement and product reviews of other commercial solutions. Ultrasonic density analysis appears to be

  18. Transportation and Aging: A Research Agenda for Advancing Safe Mobility

    ERIC Educational Resources Information Center

    Dickerson, Anne E.; Molnar, Lisa J.; Eby, David W.; Adler, Geri; Bedard, Michel; Berg-Weger, Marla; Classen, Sherrilene; Foley, Daniel; Horowitz, Amy; Kerschner, Helen; Page, Oliver; Silverstein, Nina M.; Staplin, Loren; Trujillo, Leonard

    2007-01-01

    Purpose: We review what we currently know about older driver safety and mobility, and we highlight important research needs in a number of key areas that hold promise for achieving the safety and mobility goals for the aging baby boomers and future generations of older drivers. Design and Methods: Through the use of a framework for transportation…

  19. [Advances in researches of molluscicidal microorganisms against Oncomelania hupensis].

    PubMed

    Cheng, Wan-ting; Zhou, Yi-biao; Pan, Xiang; Song, Xiu-xia; Jiang, Qing-wu

    2016-02-01

    The elimination of Oncomelania hupensis snails is important to schistosomiasis control. Recently, the application of molluscicidal organisms is considered as a safe and efficient method for snail elimination. In order to provide scientific evidences for effective control of O. hupensis and schistosomiasis, this paper summarizes the researches of molluscicidal microorganisms against O. hupensis. PMID:27356421

  20. Fossil energy: From laboratory to marketplace. Part 2, The role of advanced research

    SciTech Connect

    Not Available

    1992-03-01

    The purpose of this work is to provide a summary description of the role of advanced research in the overall Fossil Energy R&D program successes. It presents the specific Fossil Energy advanced research products that have been adopted commercially or fed into other R&D programs as part of the crosscutting enabling technology base upon which advanced systems are based.

  1. Methods and systems for advanced spaceport information management

    NASA Technical Reports Server (NTRS)

    Fussell, Ronald M. (Inventor); Ely, Donald W. (Inventor); Meier, Gary M. (Inventor); Halpin, Paul C. (Inventor); Meade, Phillip T. (Inventor); Jacobson, Craig A. (Inventor); Blackwell-Thompson, Charlie (Inventor)

    2007-01-01

    Advanced spaceport information management methods and systems are disclosed. In one embodiment, a method includes coupling a test system to the payload and transmitting one or more test signals that emulate an anticipated condition from the test system to the payload. One or more responsive signals are received from the payload into the test system and are analyzed to determine whether one or more of the responsive signals comprises an anomalous signal. At least one of the steps of transmitting, receiving, analyzing and determining includes transmitting at least one of the test signals and the responsive signals via a communications link from a payload processing facility to a remotely located facility. In one particular embodiment, the communications link is an Internet link from a payload processing facility to a remotely located facility (e.g. a launch facility, university, etc.).

  2. Methods and Systems for Advanced Spaceport Information Management

    NASA Technical Reports Server (NTRS)

    Fussell, Ronald M. (Inventor); Ely, Donald W. (Inventor); Meier, Gary M. (Inventor); Halpin, Paul C. (Inventor); Meade, Phillip T. (Inventor); Jacobson, Craig A. (Inventor); Blackwell-Thompson, Charlie (Inventor)

    2007-01-01

    Advanced spaceport information management methods and systems are disclosed. In one embodiment, a method includes coupling a test system to the payload and transmitting one or more test signals that emulate an anticipated condition from the test system to the payload. One or more responsive signals are received from the payload into the test system and are analyzed to determine whether one or more of the responsive signals comprises an anomalous signal. At least one of the steps of transmitting, receiving, analyzing and determining includes transmitting at least one of the test signals and the responsive signals via a communications link from a payload processing facility to a remotely located facility. In one particular embodiment, the communications link is an Internet link from a payload processing facility to a remotely located facility (e.g. a launch facility, university, etc.).

  3. Health, wealth, and air pollution: advancing theory and methods.

    PubMed Central

    O'Neill, Marie S; Jerrett, Michael; Kawachi, Ichiro; Levy, Jonathan I; Cohen, Aaron J; Gouveia, Nelson; Wilkinson, Paul; Fletcher, Tony; Cifuentes, Luis; Schwartz, Joel

    2003-01-01

    The effects of both ambient air pollution and socioeconomic position (SEP) on health are well documented. A limited number of recent studies suggest that SEP may itself play a role in the epidemiology of disease and death associated with exposure to air pollution. Together with evidence that poor and working-class communities are often more exposed to air pollution, these studies have stimulated discussion among scientists, policy makers, and the public about the differential distribution of the health impacts from air pollution. Science and public policy would benefit from additional research that integrates the theory and practice from both air pollution and social epidemiologies to gain a better understanding of this issue. In this article we aim to promote such research by introducing readers to methodologic and conceptual approaches in the fields of air pollution and social epidemiology; by proposing theories and hypotheses about how air pollution and socioeconomic factors may interact to influence health, drawing on studies conducted worldwide; by discussing methodologic issues in the design and analysis of studies to determine whether health effects of exposure to ambient air pollution are modified by SEP; and by proposing specific steps that will advance knowledge in this field, fill information gaps, and apply research results to improve public health in collaboration with affected communities. PMID:14644658

  4. A Graduate Course in Research Methods.

    ERIC Educational Resources Information Center

    Burrows, Veronica A.; Beaudoin, Stephen P.

    2001-01-01

    Describes the development of a graduate-level research methods course to develop necessary skills such as project management and communication among graduate students. Uses a team-based, active/collaborative teaching approach. (Author/YDS)

  5. Research on chemical vapor deposition processes for advanced ceramic coatings

    NASA Technical Reports Server (NTRS)

    Rosner, Daniel E.

    1993-01-01

    Our interdisciplinary background and fundamentally-oriented studies of the laws governing multi-component chemical vapor deposition (VD), particle deposition (PD), and their interactions, put the Yale University HTCRE Laboratory in a unique position to significantly advance the 'state-of-the-art' of chemical vapor deposition (CVD) R&D. With NASA-Lewis RC financial support, we initiated a program in March of 1988 that has led to the advances described in this report (Section 2) in predicting chemical vapor transport in high temperature systems relevant to the fabrication of refractory ceramic coatings for turbine engine components. This Final Report covers our principal results and activities for the total NASA grant of $190,000. over the 4.67 year period: 1 March 1988-1 November 1992. Since our methods and the technical details are contained in the publications listed (9 Abstracts are given as Appendices) our emphasis here is on broad conclusions/implications and administrative data, including personnel, talks, interactions with industry, and some known applications of our work.

  6. Research Methods in the Social Sciences

    ERIC Educational Resources Information Center

    Somekh, Bridget, Ed.; Lewin, Cathy, Ed.

    2005-01-01

    This book is intended as a resource and an indispensable companion to welcome educators into the community of social science research. While it is recognized that some methodological frameworks are incompatible with others, the overarching premise of the book is to indicate how a wide range of researchers choose a methodology and methods which are…

  7. Theory and Methods of Research on Aging.

    ERIC Educational Resources Information Center

    Schaie, K. Warner, Ed.

    The document reports the proceedings of a conference on "Theory and Methods of Research on Aging" held under the auspices of the Division of Maturity and Old Age of the American Psychological Association, the Department of Psychology and the Human Resources Research Institute of West Virginia University, May 17-19, 1967. The summaries of four…

  8. Mixed Methods Research Designs in Counseling Psychology

    ERIC Educational Resources Information Center

    Hanson, William E.; Creswell, John W.; Clark, Vicki L. Plano; Petska, Kelly S.; Creswell, David J.

    2005-01-01

    With the increased popularity of qualitative research, researchers in counseling psychology are expanding their methodologies to include mixed methods designs. These designs involve the collection, analysis, and integration of quantitative and qualitative data in a single or multiphase study. This article presents an overview of mixed methods…

  9. A Collaborative Group Method of Inclusive Research

    ERIC Educational Resources Information Center

    Bigby, Christine; Frawley, Patsie; Ramcharan, Paul

    2014-01-01

    Background: Funding bodies in Australia and the United Kingdom require research on issues that affect the lives of people with intellectual disability to be inclusive. Debate continues about the nature and benefits of inclusive research, which has become an umbrella term encompassing a broad spectrum of approaches. Method: This study proposes one…

  10. [Research advances in cadmium pollution of peanut (Arachis hypogaea L.)].

    PubMed

    Wang, Kai-rong; Zhang, Lei

    2008-12-01

    Peanut (Arachis hypogaea L.) is a major oil-bearing crop in the world, and as well, an important resource of plant protein and a main raw material for food processing. With the increasing of its direct human consumption and food processing, the Cd concentration in peanut kernel has aroused great concern in recent years. China is a main country of the production and exportation of peanut, but the Cd enrichment in peanut kernel is the main obstacle for its peanut export trade. In this paper, the research advances in Cd pollution of peanut kernel were reviewed, based on the characteristics and mechanisms of Cd accumulation and distribution in peanut kernel, the intra-specific variation of kernel Cd content, and the measures in controlling kernel Cd content. Two strategies were put forward for controlling Cd pollution of peanut kernel, i.e., to reduce the Cd uptake by main root system of peanut plant, and to control the transference of Cd from root to fruit (kernel). In order to applying the strategies effectively, researches on the mechanisms of Cd accumulation in peanut kernel should be enhanced in three aspects, i.e., root vitality and its relationship with Cd accumulation in kernel, mechanism of fruit Cd absorption and its contribution to kernel Cd content, and mechanism of Cd transference in plants and its effects on kernel Cd content.

  11. Fingerprint identification: advances since the 2009 National Research Council report

    PubMed Central

    Champod, Christophe

    2015-01-01

    This paper will discuss the major developments in the area of fingerprint identification that followed the publication of the National Research Council (NRC, of the US National Academies of Sciences) report in 2009 entitled: Strengthening Forensic Science in the United States: A Path Forward. The report portrayed an image of a field of expertise used for decades without the necessary scientific research-based underpinning. The advances since the report and the needs in selected areas of fingerprinting will be detailed. It includes the measurement of the accuracy, reliability, repeatability and reproducibility of the conclusions offered by fingerprint experts. The paper will also pay attention to the development of statistical models allowing assessment of fingerprint comparisons. As a corollary of these developments, the next challenge is to reconcile a traditional practice dominated by deterministic conclusions with the probabilistic logic of any statistical model. There is a call for greater candour and fingerprint experts will need to communicate differently on the strengths and limitations of their findings. Their testimony will have to go beyond the blunt assertion of the uniqueness of fingerprints or the opinion delivered ispe dixit. PMID:26101284

  12. Advances in knowledge management for pharmaceutical research and development.

    PubMed

    Torr-Brown, Sheryl

    2005-05-01

    There are two assumptions that are taken for granted in the pharmaceutical industry today. Firstly, that we can generate an unprecedented amount of drug-related information along the research and development (R&D) pipeline, and secondly, that researchers are more connected to each other than they have ever been, owing to the internet revolution of the past 15 years or so. Both of these aspects of the modern pharmaceutical company have brought many benefits to the business. However, the pharmaceutical industry is currently under fire due to allegations of decreased productivity despite significant investments in R&D, which if left to continue at the present pace, will reach almost US 60 billion dollars by 2006. This article explores the role of knowledge in the industry and reviews recent developments and emerging opportunities in the field of knowledge management (KM) as it applies to pharmaceutical R&D. It is argued that systematic KM will be increasingly necessary to optimize the value of preceding advances in high-throughput approaches to R&D, and to fully realize the anticipated increase in productivity. The application of KM principles and practices to the business can highlight opportunities for balancing the current reliance on blockbuster drugs with a more patient-centric focus on human health, which is now becoming possible. PMID:15892246

  13. Advances in knowledge management for pharmaceutical research and development.

    PubMed

    Torr-Brown, Sheryl

    2005-05-01

    There are two assumptions that are taken for granted in the pharmaceutical industry today. Firstly, that we can generate an unprecedented amount of drug-related information along the research and development (R&D) pipeline, and secondly, that researchers are more connected to each other than they have ever been, owing to the internet revolution of the past 15 years or so. Both of these aspects of the modern pharmaceutical company have brought many benefits to the business. However, the pharmaceutical industry is currently under fire due to allegations of decreased productivity despite significant investments in R&D, which if left to continue at the present pace, will reach almost US 60 billion dollars by 2006. This article explores the role of knowledge in the industry and reviews recent developments and emerging opportunities in the field of knowledge management (KM) as it applies to pharmaceutical R&D. It is argued that systematic KM will be increasingly necessary to optimize the value of preceding advances in high-throughput approaches to R&D, and to fully realize the anticipated increase in productivity. The application of KM principles and practices to the business can highlight opportunities for balancing the current reliance on blockbuster drugs with a more patient-centric focus on human health, which is now becoming possible.

  14. Research advances in plant-made flavivirus antigens.

    PubMed

    Martínez, C A; Giulietti, A M; Talou, J Rodríguez

    2012-01-01

    Outbreaks of flaviviruses such as dengue (DV), yellow fever (YFV), Japanese encephalitis (JEV), tick-borne encephalitis (TBEV) and West Nile (WNV) affect numerous countries around the world. The fast spread of these viruses is the result of increases in the human population, rapid urbanisation and globalisation. While vector control is an important preventive measure against vector-borne diseases, it has failed to prevent the spread of these diseases, particularly in developing countries where the implementation of control measures is intermittent. As antiviral drugs against flaviviruses are not yet available, vaccination remains the most important tool for prevention. Although human vaccines for YFV, TBEV and JEV are available, on-going vaccination efforts are insufficient to prevent infection. No vaccines against DENV and WNV are available. Research advances have provided important tools for flavivirus vaccine development, such as the use of plants as a recombinant antigen production platform. This review summarises the research efforts in this area and highlights why a plant system is considered a necessary alternative production platform for high-tech subunit vaccines. PMID:22480936

  15. Fingerprint identification: advances since the 2009 National Research Council report.

    PubMed

    Champod, Christophe

    2015-08-01

    This paper will discuss the major developments in the area of fingerprint identification that followed the publication of the National Research Council (NRC, of the US National Academies of Sciences) report in 2009 entitled: Strengthening Forensic Science in the United States: A Path Forward. The report portrayed an image of a field of expertise used for decades without the necessary scientific research-based underpinning. The advances since the report and the needs in selected areas of fingerprinting will be detailed. It includes the measurement of the accuracy, reliability, repeatability and reproducibility of the conclusions offered by fingerprint experts. The paper will also pay attention to the development of statistical models allowing assessment of fingerprint comparisons. As a corollary of these developments, the next challenge is to reconcile a traditional practice dominated by deterministic conclusions with the probabilistic logic of any statistical model. There is a call for greater candour and fingerprint experts will need to communicate differently on the strengths and limitations of their findings. Their testimony will have to go beyond the blunt assertion of the uniqueness of fingerprints or the opinion delivered ispe dixit.

  16. Research advances in plant-made flavivirus antigens.

    PubMed

    Martínez, C A; Giulietti, A M; Talou, J Rodríguez

    2012-01-01

    Outbreaks of flaviviruses such as dengue (DV), yellow fever (YFV), Japanese encephalitis (JEV), tick-borne encephalitis (TBEV) and West Nile (WNV) affect numerous countries around the world. The fast spread of these viruses is the result of increases in the human population, rapid urbanisation and globalisation. While vector control is an important preventive measure against vector-borne diseases, it has failed to prevent the spread of these diseases, particularly in developing countries where the implementation of control measures is intermittent. As antiviral drugs against flaviviruses are not yet available, vaccination remains the most important tool for prevention. Although human vaccines for YFV, TBEV and JEV are available, on-going vaccination efforts are insufficient to prevent infection. No vaccines against DENV and WNV are available. Research advances have provided important tools for flavivirus vaccine development, such as the use of plants as a recombinant antigen production platform. This review summarises the research efforts in this area and highlights why a plant system is considered a necessary alternative production platform for high-tech subunit vaccines.

  17. Mapping Mixed Methods Research: Methods, Measures, and Meaning

    ERIC Educational Resources Information Center

    Wheeldon, J.

    2010-01-01

    This article explores how concept maps and mind maps can be used as data collection tools in mixed methods research to combine the clarity of quantitative counts with the nuance of qualitative reflections. Based on more traditional mixed methods approaches, this article details how the use of pre/post concept maps can be used to design qualitative…

  18. ARCHES: Advancing Research & Capacity in Hydrologic Education and Science

    NASA Astrophysics Data System (ADS)

    Milewski, A.; Fryar, A. E.; Durham, M. C.; Schroeder, P.; Agouridis, C.; Hanley, C.; Rotz, R. R.

    2013-12-01

    Educating young scientists and building capacity on a global scale is pivotal towards better understanding and managing our water resources. Based on this premise the ARCHES (Advancing Research & Capacity in Hydrologic Education and Science) program has been established. This abstract provides an overview of the program, links to access information, and describes the activities and outcomes of student participants from the Middle East and North Africa. The ARCHES program (http://arches.wrrs.uga.edu) is an integrated hydrologic education approach using online courses, field programs, and various hands-on workshops. The program aims to enable young scientists to effectively perform the high level research that will ultimately improve quality of life, enhance science-based decision making, and facilitate collaboration. Three broad, interlinked sets of activities are incorporated into the ARCHES program: (A1) the development of technical expertise, (A2) the development of professional contacts and skills, and (A3) outreach and long-term sustainability. The development of technical expertise (A1) is implemented through three progressive instructional sections. Section 1: Students were guided through a series of online lectures and exercises (Moodle: http://wrrs.uga.edu/moodle) covering three main topics (Remote Sensing, GIS, and Hydrologic Modeling). Section 2: Students participated in a hands-on workshop hosted at the University of Georgia's Water Resources and Remote Sensing Laboratory (WRRSL). Using ENVI, ArcGIS, and ArcSWAT, students completed a series of lectures and real-world applications (e.g., Development of Hydrologic Models). Section 3: Students participated in field studies (e.g., measurements of infiltration, recharge, streamflow, and water-quality parameters) conducted by U.S. partners and international collaborators in the participating countries. The development of professional contacts and skills (A2) was achieved through the promotion of networking

  19. [Advanced Gas Turbine Systems Research]. Technical Quarterly Progress Report

    SciTech Connect

    1998-09-30

    Major Accomplishments by Advanced Gas Turbine Systems Research (AGTSR) during this reporting period are highlighted below and amplified in later sections of this report: AGTSR distributed 50 proposals from the 98RFP to the IRB for review, evaluation and rank-ordering during the summer; AGTSR conducted a detailed program review at DOE-FETC on July 24; AGTSR organized the 1998 IRB proposal review meeting at SCIES on September 15-16; AGTSR consolidated all the IRB proposal scores and rank-orderings to facilitate the 98RFP proposal deliberations; AGTSR submitted meeting minutes and proposal short-list recommendation to the IRB and DOE for the 98RFP solicitation; AGTSR reviewed two gas turbine related proposals as part of the CU RFP State Project for renovating the central energy facility; AGTSR reviewed and cleared research papers with the IRB from the University of Pittsburgh, Wisconsin, and Minnesota; AGTSR assisted GTA in obtaining university stakeholder support of the ATS program from California, Pennsylvania, and Colorado; AGTSR assisted GTA in distributing alert notices on potential ATS budget cuts to over 150 AGTSR performing university members; AGTSR submitted proceedings booklet and organizational information pertaining to the OAI hybrid gas turbine workshop to DOE-FETC; For DOE-FETC, AGTSR updated the university consortium poster to include new members and research highlights; For DOE-FETC, the general AGTSR Fact Sheet was updated to include new awards, workshops, educational activity and select accomplishments from the research projects; For DOE-FETC, AGTSR prepared three fact sheets highlighting university research supported in combustion, aero-heat transfer, and materials; For DOE-FETC, AGTSR submitted pictures on materials research for inclusion in the ATS technology brochure; For DOE-FETC, AGTSR submitted a post-2000 roadmap showing potential technology paths AGTSR could pursue in the next decade; AGTSR distributed the ninth newsletter UPDATE to DOE, the

  20. Advanced Stirling Convertor Testing at NASA Glenn Research Center

    NASA Technical Reports Server (NTRS)

    Wilson, Scott D.; Poriti, Sal

    2010-01-01

    The NASA Glenn Research Center (GRC) has been testing high-efficiency free-piston Stirling convertors for potential use in radioisotope power systems (RPSs) since 1999. The current effort is in support of the Advanced Stirling Radioisotope Generator (ASRG), which is being developed by the U.S. Department of Energy (DOE), Lockheed Martin Space Systems Company (LMSSC), Sunpower, Inc., and the NASA GRC. This generator would use two high-efficiency Advanced Stirling Convertors (ASCs) to convert thermal energy from a radioisotope heat source into electricity. As reliability is paramount to a RPS capable of providing spacecraft power for potential multi-year missions, GRC provides direct technology support to the ASRG flight project in the areas of reliability, convertor and generator testing, high-temperature materials, structures, modeling and analysis, organics, structural dynamics, electromagnetic interference (EMI), and permanent magnets to reduce risk and enhance reliability of the convertor as this technology transitions toward flight status. Convertor and generator testing is carried out in short- and long-duration tests designed to characterize convertor performance when subjected to environments intended to simulate launch and space conditions. Long duration testing is intended to baseline performance and observe any performance degradation over the life of the test. Testing involves developing support hardware that enables 24/7 unattended operation and data collection. GRC currently has 14 Stirling convertors under unattended extended operation testing, including two operating in the ASRG Engineering Unit (ASRG-EU). Test data and high-temperature support hardware are discussed for ongoing and future ASC tests with emphasis on the ASC-E and ASC-E2.

  1. Recent advances in Echinococcus genomics and stem cell research.

    PubMed

    Koziol, U; Brehm, K

    2015-10-30

    Alveolar and cystic echinococcosis, caused by the metacestode larval stages of the tapeworms Echinococcus multilocularis and Echinococcus granulosus, respectively, are life-threatening diseases and very difficult to treat. The introduction of benzimidazole-based chemotherapy, which targets parasite β-tubulin, has significantly improved the life-span and prognosis of echinococcosis patients. However, benzimidazoles show only parasitostatic activity, are associated with serious adverse side effects and have to be administered for very long time periods, underlining the need for new drugs. Very recently, the nuclear genomes of E. multilocularis and E. granulosus have been characterised, revealing a plethora of data for gaining a deeper understanding of host-parasite interaction, parasite development and parasite evolution. Combined with extensive transcriptome analyses of Echinococcus life cycle stages these investigations also yielded novel clues for targeted drug design. Recent years also witnessed significant advancements in the molecular and cellular characterisation of the Echinococcus 'germinative cell' population, which forms a unique stem cell system that differs from stem cells of other organisms in the expression of several genes associated with the maintenance of pluripotency. As the only parasite cell type capable of undergoing mitosis, the germinative cells are central to all developmental transitions of Echinococcus within the host and to parasite expansion via asexual proliferation. In the present article, we will briefly introduce and discuss recent advances in Echinococcus genomics and stem cell research in the context of drug design and development. Interestingly, it turns out that benzimidazoles seem to have very limited effects on Echinococcus germinative cells, which could explain the high recurrence rates observed after chemotherapeutic treatment of echinococcosis patients. This clearly indicates that future efforts into the development of

  2. Recent advances in Echinococcus genomics and stem cell research.

    PubMed

    Koziol, U; Brehm, K

    2015-10-30

    Alveolar and cystic echinococcosis, caused by the metacestode larval stages of the tapeworms Echinococcus multilocularis and Echinococcus granulosus, respectively, are life-threatening diseases and very difficult to treat. The introduction of benzimidazole-based chemotherapy, which targets parasite β-tubulin, has significantly improved the life-span and prognosis of echinococcosis patients. However, benzimidazoles show only parasitostatic activity, are associated with serious adverse side effects and have to be administered for very long time periods, underlining the need for new drugs. Very recently, the nuclear genomes of E. multilocularis and E. granulosus have been characterised, revealing a plethora of data for gaining a deeper understanding of host-parasite interaction, parasite development and parasite evolution. Combined with extensive transcriptome analyses of Echinococcus life cycle stages these investigations also yielded novel clues for targeted drug design. Recent years also witnessed significant advancements in the molecular and cellular characterisation of the Echinococcus 'germinative cell' population, which forms a unique stem cell system that differs from stem cells of other organisms in the expression of several genes associated with the maintenance of pluripotency. As the only parasite cell type capable of undergoing mitosis, the germinative cells are central to all developmental transitions of Echinococcus within the host and to parasite expansion via asexual proliferation. In the present article, we will briefly introduce and discuss recent advances in Echinococcus genomics and stem cell research in the context of drug design and development. Interestingly, it turns out that benzimidazoles seem to have very limited effects on Echinococcus germinative cells, which could explain the high recurrence rates observed after chemotherapeutic treatment of echinococcosis patients. This clearly indicates that future efforts into the development of

  3. Advanced superposition methods for high speed turbopump vibration analysis

    NASA Technical Reports Server (NTRS)

    Nielson, C. E.; Campany, A. D.

    1981-01-01

    The small, high pressure Mark 48 liquid hydrogen turbopump was analyzed and dynamically tested to determine the cause of high speed vibration at an operating speed of 92,400 rpm. This approaches the design point operating speed of 95,000 rpm. The initial dynamic analysis in the design stage and subsequent further analysis of the rotor only dynamics failed to predict the vibration characteristics found during testing. An advanced procedure for dynamics analysis was used in this investigation. The procedure involves developing accurate dynamic models of the rotor assembly and casing assembly by finite element analysis. The dynamically instrumented assemblies are independently rap tested to verify the analytical models. The verified models are then combined by modal superposition techniques to develop a completed turbopump model where dynamic characteristics are determined. The results of the dynamic testing and analysis obtained are presented and methods of moving the high speed vibration characteristics to speeds above the operating range are recommended. Recommendations for use of these advanced dynamic analysis procedures during initial design phases are given.

  4. Exploring the promises of intersectionality for advancing women's health research.

    PubMed

    Hankivsky, Olena; Reid, Colleen; Cormier, Renee; Varcoe, Colleen; Clark, Natalie; Benoit, Cecilia; Brotman, Shari

    2010-02-11

    locations for researchers and participants who utilize an intersectionality approach. The examples highlighted in the paper represent important shifts in the health field, demonstrating the potential of intersectionality for examining the social context of women's lives, as well as developing methods which elucidate power, create new knowledge, and have the potential to inform appropriate action to bring about positive social change.

  5. Exploring the promises of intersectionality for advancing women's health research

    PubMed Central

    2010-01-01

    locations for researchers and participants who utilize an intersectionality approach. The examples highlighted in the paper represent important shifts in the health field, demonstrating the potential of intersectionality for examining the social context of women's lives, as well as developing methods which elucidate power, create new knowledge, and have the potential to inform appropriate action to bring about positive social change. PMID:20181225

  6. Fuels for Advanced Combustion Engines Research Diesel Fuels: Analysis of Physical and Chemical Properties

    SciTech Connect

    Gallant, Tom; Franz, Jim; Alnajjar, Mikhail; Storey, John Morse; Lewis Sr, Samuel Arthur; Sluder, Scott; Cannella, William C; Fairbridge, Craig; Hager, Darcy; Dettman, Heather; Luecke, Jon; Ratcliff, Matthew A.; Zigler, Brad

    2009-01-01

    The CRC Fuels for Advanced Combustion Engines working group has worked to identify a matrix of research diesel fuels for use in advanced combustion research applications. Nine fuels were specified and formulated to investigate the effects of cetane number aromatic content and 90% distillation fraction. Standard ASTM analyses were performed on the fuels as well as GC/MS and /u1H//u1/u3C NMR analyses and thermodynamic characterizations. Details of the actual results of the fuel formulations compared with the design values are presented, as well as results from standard analyses, such as heating value, viscosity and density. Cetane number characterizations were accomplished by using both the engine method and the Ignition Quality Tester (IQT/sT) apparatus.

  7. Advance in methods studying the pharmacokinetics of polyphenols.

    PubMed

    Santos, Ana C; Costa, G; Veiga, F; Figueiredo, I V; Batista, M T; Ribeiro, António J

    2014-01-01

    Significant advances have been achieved during the past decade concerning the metabolism of polyphenol compounds in vitro, but scarce data has been presented about what really happens in vivo. Many studies on polyphenols to date have focused on the bioactivity of one specific molecule in aglycone form, often at supraphysiological doses, whereas foods contain complex, often poorly characterized mixtures with multiple additive or interfering activities. Whereas most studies up to the middle-late 1990s measured total aglycones in plasma and urine, after chemical or enzymatic deconjugation, or both, several recent works now report the polyphenol conjugate composition of plasma, urine, feces and/or tissues, after the administration of pure polyphenols or polyphenol-rich matrices. HPLC methods with electrochemical, mass spectrometric and fluorescence detection have adequate sensitivity. LC/UV-Vis methods have also been widely reported, but they are much less sensitive. Compared with electro-chemical and fluorescence detection, MS can quantify analytes without chromatographic separation, which leads to high throughput, presenting itself as the best choice to date. Regarding the experimental model to monitor the bioavailability of phenolic compounds, most published studies are based on human and animal models, with the majority using rodents, primates and recently the nematode Caenorhabditis elegans. This review focuses on the fundamentals of pharmacokinetic methods from the last 15 years and how the results are evaluated and validated. The types of analytical methods, animal models and biological matrices were used to better elucidate pharmacokinetics of polyphenols.

  8. Advanced numerical methods in mesh generation and mesh adaptation

    SciTech Connect

    Lipnikov, Konstantine; Danilov, A; Vassilevski, Y; Agonzal, A

    2010-01-01

    Numerical solution of partial differential equations requires appropriate meshes, efficient solvers and robust and reliable error estimates. Generation of high-quality meshes for complex engineering models is a non-trivial task. This task is made more difficult when the mesh has to be adapted to a problem solution. This article is focused on a synergistic approach to the mesh generation and mesh adaptation, where best properties of various mesh generation methods are combined to build efficiently simplicial meshes. First, the advancing front technique (AFT) is combined with the incremental Delaunay triangulation (DT) to build an initial mesh. Second, the metric-based mesh adaptation (MBA) method is employed to improve quality of the generated mesh and/or to adapt it to a problem solution. We demonstrate with numerical experiments that combination of all three methods is required for robust meshing of complex engineering models. The key to successful mesh generation is the high-quality of the triangles in the initial front. We use a black-box technique to improve surface meshes exported from an unattainable CAD system. The initial surface mesh is refined into a shape-regular triangulation which approximates the boundary with the same accuracy as the CAD mesh. The DT method adds robustness to the AFT. The resulting mesh is topologically correct but may contain a few slivers. The MBA uses seven local operations to modify the mesh topology. It improves significantly the mesh quality. The MBA method is also used to adapt the mesh to a problem solution to minimize computational resources required for solving the problem. The MBA has a solid theoretical background. In the first two experiments, we consider the convection-diffusion and elasticity problems. We demonstrate the optimal reduction rate of the discretization error on a sequence of adaptive strongly anisotropic meshes. The key element of the MBA method is construction of a tensor metric from hierarchical edge

  9. Dialectical Inquiry: A Structured Qualitative Research Method

    ERIC Educational Resources Information Center

    Berniker, Eli; McNabb, David E.

    2006-01-01

    This paper presents Dialectical Inquiry (DI) as a structured qualitative research method for studying participant models of organizational processes. The method is applied to rich secondary anecdotal data on technology transfer, gathered by subject-matter experts in a large firm. DI assumes that the imposition of a dialectical structure will…

  10. Phenomenological Research Methods for Counseling Psychology

    ERIC Educational Resources Information Center

    Wertz, Frederick J.

    2005-01-01

    This article familiarizes counseling psychologists with qualitative research methods in psychology developed in the tradition of European phenomenology. A brief history includes some of Edmund Husserl's basic methods and concepts, the adoption of existential-phenomenology among psychologists, and the development and formalization of qualitative…

  11. A "Handy" Way to Introduce Research Methods.

    ERIC Educational Resources Information Center

    Johnson, David E.

    1996-01-01

    Provides an exercise for introducing research methods to undergraduates. The students view a graph revealing that left-handed people are underrepresented in older age groups. Small group discussions attempt to explain this phenomenon. A follow-up class discussion focuses on the different approaches and methods available for interpreting the data.…

  12. [Research advances in eco-toxicological diagnosis of soil pollution].

    PubMed

    Liu, Feng; Teng, Hong-Hui; Ren, Bai-Xiang; Shi, Shu-Yun

    2014-09-01

    Soil eco-toxicology provides a theoretical basis for ecological risk assessment of contaminated soils and soil pollution control. Research on eco-toxicological effects and molecular mechanisms of toxic substances in soil environment is the central content of the soil eco-toxicology. Eco-toxicological diagnosis not only gathers all the information of soil pollution, but also provides the overall toxic effects of soil. Therefore, research on the eco-toxicological diagnosis of soil pollution has important theoretical and practical significance. Based on the research of eco-toxicological diagnosis of soil pollution, this paper introduced some common toxicological methods and indicators, with the advantages and disadvantages of various methods discussed. However, conventional biomarkers can only indicate the class of stress, but fail to explain the molecular mechanism of damage or response happened. Biomarkers and molecular diagnostic techniques, which are used to evaluate toxicity of contaminated soil, can explore deeply detoxification mechanisms of organisms under exogenous stress. In this paper, these biomarkers and techniques were introduced systematically, and the future research trends were prospected.

  13. Advanced Motion Compensation Methods for Intravital Optical Microscopy.

    PubMed

    Vinegoni, Claudio; Lee, Sungon; Feruglio, Paolo Fumene; Weissleder, Ralph

    2014-03-01

    Intravital microscopy has emerged in the recent decade as an indispensible imaging modality for the study of the micro-dynamics of biological processes in live animals. Technical advancements in imaging techniques and hardware components, combined with the development of novel targeted probes and new mice models, have enabled us to address long-standing questions in several biology areas such as oncology, cell biology, immunology and neuroscience. As the instrument resolution has increased, physiological motion activities have become a major obstacle that prevents imaging live animals at resolutions analogue to the ones obtained in vitro. Motion compensation techniques aim at reducing this gap and can effectively increase the in vivo resolution. This paper provides a technical review of some of the latest developments in motion compensation methods, providing organ specific solutions.

  14. Advanced Motion Compensation Methods for Intravital Optical Microscopy

    PubMed Central

    Vinegoni, Claudio; Lee, Sungon; Feruglio, Paolo Fumene; Weissleder, Ralph

    2013-01-01

    Intravital microscopy has emerged in the recent decade as an indispensible imaging modality for the study of the micro-dynamics of biological processes in live animals. Technical advancements in imaging techniques and hardware components, combined with the development of novel targeted probes and new mice models, have enabled us to address long-standing questions in several biology areas such as oncology, cell biology, immunology and neuroscience. As the instrument resolution has increased, physiological motion activities have become a major obstacle that prevents imaging live animals at resolutions analogue to the ones obtained in vitro. Motion compensation techniques aim at reducing this gap and can effectively increase the in vivo resolution. This paper provides a technical review of some of the latest developments in motion compensation methods, providing organ specific solutions. PMID:24273405

  15. Recent advances in land-atmosphere interaction research

    NASA Astrophysics Data System (ADS)

    Entekhabi, Dara

    1995-07-01

    From the earliest attempt at numerical weather prediction up until today's efforts on improving the land surface hydrologic parameterization in General Circulation models (GCMs), it has been recognized that the realistic characterization of atmospheric phenomena requires accurate representation of surficial processes. Lewis F. Richardson who attempted numerical weather prediction using hand calculations around the First World War period includes, in his notes, a parameterization of the surface evapotranspiration and plant stomatal control of the vapor exchange between land and atmosphere. He writes: "…Let the rate of loss of water from a leaf be denoted by T, thenT=K{ F(θleaf)-wair }here K is the conductance of the stomatal openings and F (θleaf) is the saturated vapour density at θ." [Richardson, 1922]. Almost three-quarters of a century later and using high-speed digital computers, the research community is essentially implementing Lewis F. Richardson's original scheme of stomatal resistance to vapor flux between the saturated interior of leaves at temperature 9ieaf and near-surface air humidity wair. At first sight it may appear that not much scientific progress has been made in the interim years. Transpiration, turbulence and other processes related to land-atmosphere exchange are complex phenomena and in fact there has been significant recent advances in the study of land-atmosphere interaction. The land, biosphere, atmosphere and ocean systems are coupled across a wide range of space and time scales such that each discovery leads to a deeper and larger scientific question. Research inquiry in this area is now performed in both the hydrologic and the atmospheric science communities.

  16. Research advances in esophageal diseases: bench to bedside

    PubMed Central

    di Pietro, Massimiliano

    2013-01-01

    Over the last year, significant steps have been made toward understanding the pathogenesis of esophageal diseases and translating this knowledge to clinical practice. Gastroesophageal reflux disease (GERD) is the most common outpatient diagnosis in gastroenterology and has a high prevalence in the general population. As many as 40% of patients with GERD have incomplete response to medical therapy, and the pathophysiological mechanisms underlying lack of response are now better understood. Novel medical and minimally invasive interventions are available to optimize management of GERD. Esophageal cancer, regardless of the histological subtype, has among the worst survival statistics among all malignancies. Taking advantage of technological advances in genome sequencing, the mutational spectra in esophageal cancer are now emerging, offering novel avenues for targeted therapies. Early diagnosis is another strand for improving survival. While genome-wide association studies are providing insights into genetic susceptibility, novel approaches to early detection of cancer are being devised through the use of biomarkers applied to esophageal samples and as part of imaging technologies. Dysmotility and eosinophilic esophagitis are the differential diagnoses in patients with dysphagia. New pathophysiological classifications have improved the management of motility disorders. Meanwhile, exciting progress has been made in the endoscopic management of these conditions. Eosinophilic esophagitis is still a relatively new entity, and the pathogenesis remains poorly understood. However, it is now clear that an allergic reaction to food plays an important role, and dietary interventions as well as biologic agents to block the inflammatory cascade are novel, promising fields of clinical research. PMID:24167725

  17. Hepatocyte and Sertoli Cell Aquaporins, Recent Advances and Research Trends

    PubMed Central

    Bernardino, Raquel L.; Marinelli, Raul A.; Maggio, Anna; Gena, Patrizia; Cataldo, Ilaria; Alves, Marco G.; Svelto, Maria; Oliveira, Pedro F.; Calamita, Giuseppe

    2016-01-01

    Aquaporins (AQPs) are proteinaceous channels widespread in nature where they allow facilitated permeation of water and uncharged through cellular membranes. AQPs play a number of important roles in both health and disease. This review focuses on the most recent advances and research trends regarding the expression and modulation, as well as physiological and pathophysiological functions of AQPs in hepatocytes and Sertoli cells (SCs). Besides their involvement in bile formation, hepatocyte AQPs are involved in maintaining energy balance acting in hepatic gluconeogenesis and lipid metabolism, and in critical processes such as ammonia detoxification and mitochondrial output of hydrogen peroxide. Roles are played in clinical disorders including fatty liver disease, diabetes, obesity, cholestasis, hepatic cirrhosis and hepatocarcinoma. In the seminiferous tubules, particularly in SCs, AQPs are also widely expressed and seem to be implicated in the various stages of spermatogenesis. Like in hepatocytes, AQPs may be involved in maintaining energy homeostasis in these cells and have a major role in the metabolic cooperation established in the testicular tissue. Altogether, this information represents the mainstay of current and future investigation in an expanding field. PMID:27409609

  18. Cooperative Research and Development for Advanced Microturbines Program on Advanced Integrated Microturbine System

    SciTech Connect

    Michael J. Bowman

    2007-05-30

    The Advanced Integrated Microturbine Systems (AIMS) project was kicked off in October of 2000 to develop the next generation microturbine system. The overall objective of the project was to develop a design for a 40% electrical efficiency microturbine system and demonstrate many of the enabling technologies. The project was initiated as a collaborative effort between several units of GE, Elliott Energy Systems, Turbo Genset, Oak Ridge National Lab and Kyocera. Since the inception of the project the partners have changed but the overall direction of the project has stayed consistent. The project began as a systems study to identify design options to achieve the ultimate goal of 40% electrical efficiency. Once the optimized analytical design was identified for the 40% system, it was determined that a 35% efficient machine would be capable of demonstrating many of the advanced technologies within the given budget and timeframe. The items that would not be experimentally demonstrated were fully produced ceramic parts. However, to understand the requirements of these ceramics, an effort was included in the project to experimentally evaluate candidate materials in representative conditions. The results from this effort would clearly identify the challenges and improvement required of these materials for the full design. Following the analytical effort, the project was dedicated to component development and testing. Each component and subsystem was designed with the overall system requirements in mind and each tested to the fullest extent possible prior to being integrated together. This method of component development and evaluation helps to minimize the technical risk of the project. Once all of the components were completed, they were assembled into the full system and experimentally evaluated.

  19. Investigation of advanced fault insertion and simulator methods

    NASA Technical Reports Server (NTRS)

    Dunn, W. R.; Cottrell, D.

    1986-01-01

    The cooperative agreement partly supported research leading to the open-literature publication cited. Additional efforts under the agreement included research into fault modeling of semiconductor devices. Results of this research are presented in this report which is summarized in the following paragraphs. As a result of the cited research, it appears that semiconductor failure mechanism data is abundant but of little use in developing pin-level device models. Failure mode data on the other hand does exist but is too sparse to be of any statistical use in developing fault models. What is significant in the failure mode data is that, unlike classical logic, MSI and LSI devices do exhibit more than 'stuck-at' and open/short failure modes. Specifically they are dominated by parametric failures and functional anomalies that can include intermittent faults and multiple-pin failures. The report discusses methods of developing composite pin-level models based on extrapolation of semiconductor device failure mechanisms, failure modes, results of temperature stress testing and functional modeling. Limitations of this model particularly with regard to determination of fault detection coverage and latency time measurement are discussed. Indicated research directions are presented.

  20. Advanced Photon Source research: Volume 1, Number 1, April 1998

    SciTech Connect

    1998-04-01

    The following articles are included in this publication: (1) The Advanced Photon Source: A Brief Overview; (2) MAD Analysis of FHIT at the Structural Biology Center; (3) Advances in High-Energy-Resolution X-ray Scattering at Beamline 3-ID; (4) X-ray Imaging and Microspectroscopy of the Mycorrhyizal Fungus-Plant Symbiosis; (5) Measurement and Control of Particle-beam Trajectories in the Advanced Photon Storage Ring; (6) Beam Acceleration and Storage at the Advanced Photon Source; and (7) Experimental Facilities Operations and Current Status.

  1. Left Ventricular Flow Analysis: Recent Advances in Numerical Methods and Applications in Cardiac Ultrasound

    PubMed Central

    Borazjani, Iman; Westerdale, John; McMahon, Eileen M.; Rajaraman, Prathish K.; Heys, Jeffrey J.

    2013-01-01

    The left ventricle (LV) pumps oxygenated blood from the lungs to the rest of the body through systemic circulation. The efficiency of such a pumping function is dependent on blood flow within the LV chamber. It is therefore crucial to accurately characterize LV hemodynamics. Improved understanding of LV hemodynamics is expected to provide important clinical diagnostic and prognostic information. We review the recent advances in numerical and experimental methods for characterizing LV flows and focus on analysis of intraventricular flow fields by echocardiographic particle image velocimetry (echo-PIV), due to its potential for broad and practical utility. Future research directions to advance patient-specific LV simulations include development of methods capable of resolving heart valves, higher temporal resolution, automated generation of three-dimensional (3D) geometry, and incorporating actual flow measurements into the numerical solution of the 3D cardiovascular fluid dynamics. PMID:23690874

  2. Is Mixed Methods Research Used in Australian Career Development Research?

    ERIC Educational Resources Information Center

    Cameron, Roslyn

    2010-01-01

    Mixed methods research has become a substantive and growing methodological force that is growing in popularity within the human and social sciences. This article reports the findings of a study that has systematically reviewed articles from the "Australian Journal of Career Development" from 2004 to 2009. The aim of the study was to provide a…

  3. Study on the Integrated Geophysic Methods and Application of Advanced Geological Detection for Complicated Tunnel

    NASA Astrophysics Data System (ADS)

    Zhou, L.; Xiao, G.

    2014-12-01

    formulated a suite of comprehensive application system of seismic and electromagnetic methods for the advanced geological exploration of complicated tunnels. This research is funded by National Natural Science Foundation of China (Grant No. 41202223) .

  4. Advanced statistical methods for the definition of new staging models.

    PubMed

    Kates, Ronald; Schmitt, Manfred; Harbeck, Nadia

    2003-01-01

    Adequate staging procedures are the prerequisite for individualized therapy concepts in cancer, particularly in the adjuvant setting. Molecular staging markers tend to characterize specific, fundamental disease processes to a greater extent than conventional staging markers. At the biological level, the course of the disease will almost certainly involve interactions between multiple underlying processes. Since new therapeutic strategies tend to target specific processes as well, their impact will also involve interactions. Hence, assessment of the prognostic impact of new markers and their utilization for prediction of response to therapy will require increasingly sophisticated statistical tools that are capable of detecting and modeling complicated interactions. Because they are designed to model arbitrary interactions, neural networks offer a promising approach to improved staging. However, the typical clinical data environment poses severe challenges to high-performance survival modeling using neural nets, particularly the key problem of maintaining good generalization. Nonetheless, it turns out that by using newly developed methods to minimize unnecessary complexity in the neural network representation of disease course, it is possible to obtain models with high predictive performance. This performance has been validated on both simulated and real patient data sets. There are important applications for design of studies involving targeted therapy concepts and for identification of the improvement in decision support resulting from new staging markers. In this article, advantages of advanced statistical methods such as neural networks for definition of new staging models will be illustrated using breast cancer as an example.

  5. [Research advances in simulating land water-carbon coupling].

    PubMed

    Liu, Ning; Sun, Peng-Sen; Liu, Shi-Rong

    2012-11-01

    The increasing demand of adaptive management of land, forest, and water resources under the background of global change and water resources crisis has promoted the comprehensive study of coupling ecosystem water and carbon cycles and their restrictive relations. To construct the water-carbon coupling model and to approach the ecosystem water-carbon balance and its interactive response mechanisms under climate change at multiple spatiotemporal scales is nowadays a major concern. After reviewing the coupling relationships of water and carbon at various scales, this paper explored the implications and estimation methods of the key processes and related parameters of water-carbon coupling, the construction of evapotranspiration model at large scale based on RS, and the importance of this model in water-carbon coupling researches. The applications of assimilative multivariate data in water-carbon coupling researches under future climate change scenarios were also prospected.

  6. Advances in glucose metabolism research in colorectal cancer

    PubMed Central

    Fang, Sitian; Fang, Xiao

    2016-01-01

    Cancer cells uptake glucose at a higher rate and produce lactic acid rather than metabolizing pyruvate through the tricarboxylic acid cycle. This adaptive metabolic shift is termed the Warburg effect. Recently progress had been made regarding the mechanistic understanding of glucose metabolism and associated diagnostic and therapeutic methods, which have been investigated in colorectal cancer. The majority of novel mechanisms involve important glucose metabolism associated genes and miRNA regulation. The present review discusses the contribution of these research results to facilitate with the development of novel diagnosis and anticancer treatment options. PMID:27602209

  7. Advances in glucose metabolism research in colorectal cancer

    PubMed Central

    Fang, Sitian; Fang, Xiao

    2016-01-01

    Cancer cells uptake glucose at a higher rate and produce lactic acid rather than metabolizing pyruvate through the tricarboxylic acid cycle. This adaptive metabolic shift is termed the Warburg effect. Recently progress had been made regarding the mechanistic understanding of glucose metabolism and associated diagnostic and therapeutic methods, which have been investigated in colorectal cancer. The majority of novel mechanisms involve important glucose metabolism associated genes and miRNA regulation. The present review discusses the contribution of these research results to facilitate with the development of novel diagnosis and anticancer treatment options.

  8. Literary Discussions and Advanced Speaking Functions: Researching the (Dis)Connection

    ERIC Educational Resources Information Center

    Donato, Richard; Brooks, Frank B.

    2004-01-01

    This study investigated the discourse of class discussion in the advanced undergraduate Spanish literature course. Motivating this study was the need for research to determine how discussion in advanced undergraduate literature courses provides discourse opportunities to students to develop advanced language functions, as defined in the ACTFL…

  9. Advanced Coal Liquefaction Research and Development Facility, Wilsonville, Alabama

    SciTech Connect

    Not Available

    1992-01-01

    This report presents the results of Run 260 performed at the Advanced Coal Liquefaction R D Facility in Wilsonville. The run was started on July 17, 1990 and continued until November 14, 1990, operating in the Close-Coupled Integrated Two-Stage Liquefaction mode processing Black Thunder mine subbituminous coal (Wyodak-Anderson seam from Wyoming Powder River Basin). Both thermal/catalytic and catalytic/thermal tests were performed to determine the methods for reducing solids buildup in a subbituminous coal operation, and to improve product yields. A new, smaller interstage separator was tested to reduce solids buildup by increasing the slurry space velocity in the separator. In order to obtain improved coal and resid conversions (compared to Run 258) full-volume thermal reactor and 3/4-volume catalytic reactor were used. Shell 324 catalyst, 1/16 in. cylindrical extrudate, at a replacement rate of 3 lb/ton of MF coal was used in the catalytic stage. Iron oxide was used as slurry catalyst at a rate of 2 wt % MF coal throughout the run. (TNPS was the sulfiding agent.)

  10. Critical research and advanced technology (CRT) support project

    NASA Technical Reports Server (NTRS)

    Furman, E. R.; Anderson, D. N.; Hodge, P. E.; Lowell, C. E.; Nainiger, J. J.; Schultz, D. F.

    1983-01-01

    A critical technology base for utility and industrial gas turbines by planning the use of coal-derived fuels was studied. Development tasks were included in the following areas: (1) Combustion - investigate the combustion of coal-derived fuels and methods to minimize the conversion of fuel-bound nitrogen to NOx; (2) materials - understand and minimize hot corrosion; (3) system studies - integrate and focus the technological efforts. A literature survey of coal-derived fuels was completed and a NOx emissions model was developed. Flametube tests of a two-stage (rich-lean) combustor defined optimum equivalence ratios for minimizing NOx emissions. Sector combustor tests demonstrated variable air control to optimize equivalence ratios over a wide load range and steam cooling of the primary zone liner. The catalytic combustion of coal-derived fuels was demonstrated. The combustion of coal-derived gases is very promising. A hot-corrosion life prediction model was formulated and verified with laboratory testing of doped fuels. Fuel additives to control sulfur corrosion were studied. The intermittent application of barium proved effective. Advanced thermal barrier coatings were developed and tested. Coating failure modes were identified and new material formulations and fabrication parameters were specified. System studies in support of the thermal barrier coating development were accomplished.

  11. UTILITY OF MECHANISTIC MODELS FOR DIRECTING ADVANCED SEPARATIONS RESEARCH & DEVELOPMENT ACTIVITIES: Electrochemically Modulated Separation Example

    SciTech Connect

    Schwantes, Jon M.

    2009-06-01

    The objective for this work was to demonstrate the utility of mechanistic computer models designed to simulate actinide behavior for use in efficiently and effectively directing advanced laboratory R&D activities associated with developing advanced separations methods.

  12. Advanced aircraft service life monitoring method via flight-by-flight load spectra

    NASA Astrophysics Data System (ADS)

    Lee, Hongchul

    This research is an effort to understand current method and to propose an advanced method for Damage Tolerance Analysis (DTA) for the purpose of monitoring the aircraft service life. As one of tasks in the DTA, the current indirect Individual Aircraft Tracking (IAT) method for the F-16C/D Block 32 does not properly represent changes in flight usage severity affecting structural fatigue life. Therefore, an advanced aircraft service life monitoring method based on flight-by-flight load spectra is proposed and recommended for IAT program to track consumed fatigue life as an alternative to the current method which is based on the crack severity index (CSI) value. Damage Tolerance is one of aircraft design philosophies to ensure that aging aircrafts satisfy structural reliability in terms of fatigue failures throughout their service periods. IAT program, one of the most important tasks of DTA, is able to track potential structural crack growth at critical areas in the major airframe structural components of individual aircraft. The F-16C/D aircraft is equipped with a flight data recorder to monitor flight usage and provide the data to support structural load analysis. However, limited memory of flight data recorder allows user to monitor individual aircraft fatigue usage in terms of only the vertical inertia (NzW) data for calculating Crack Severity Index (CSI) value which defines the relative maneuver severity. Current IAT method for the F-16C/D Block 32 based on CSI value calculated from NzW is shown to be not accurate enough to monitor individual aircraft fatigue usage due to several problems. The proposed advanced aircraft service life monitoring method based on flight-by-flight load spectra is recommended as an improved method for the F-16C/D Block 32 aircraft. Flight-by-flight load spectra was generated from downloaded Crash Survival Flight Data Recorder (CSFDR) data by calculating loads for each time hack in selected flight data utilizing loads equations. From

  13. Higher Education Research Methodology-Literature Method

    ERIC Educational Resources Information Center

    Lin, Guijuan

    2009-01-01

    Starting by a brief introduction of literature method, this paper raises the question of how to choose representative research literatures. For this question, Professor Hongcai Wang points out the root of this problem and the strategies to resolve it and provides the ways to choose representative literatures. Through analyzing and summarizing,…

  14. Using Experimental Methods in Higher Education Research

    ERIC Educational Resources Information Center

    Ross, Steven M.; Morrison, Gary R.; Lowther, Deborah L.

    2005-01-01

    Experimental methods have been used extensively for many years to conduct research in education and psychology. However, applications of experiments to investigate technology and other instructional innovations in higher education settings have been relatively limited. The present paper examines ways in which experiments can be used productively…

  15. A Virtual Lab in Research Methods

    ERIC Educational Resources Information Center

    Sommer, Barbara A.; Sommer, Robert

    2003-01-01

    A hands-on lab for a lower division research methods course used an online format with Web page, Web forms, an e-mail listproc, and chat room. The virtual section received a higher rating for overall value than did the in-person labs. Students liked its convenience and flexibility. There were no significant differences in examination performance…

  16. Redesigning a Research Methods Course for Teachers

    ERIC Educational Resources Information Center

    Eastmond, J. Nicholls; Louviere, John; Quinn, Kerry

    2008-01-01

    This article describes how a team of instructional support personnel redesigned an online graduate course in research methods for pre-service and in-service teachers. The course has been taught annually each spring semester since it went online in 2000. The major revision in the online version of the class was to use a series of path simulations,…

  17. Relevant Research on Audio-Tutorial Methods

    ERIC Educational Resources Information Center

    Novak, Joseph D.

    1970-01-01

    Reviews two aspects of research related to audio-tutorial instructional methods. First, the learning theory of David P. Ausebel is summarized and applied to instructional procedures. Secondly, learning time for attainment of concept and knowledge levels is discussed. Concludes that studies are needed on designs based on Ausebel's theory,…

  18. Recent advances in research on nitrergic nerve-mediated vasodilatation.

    PubMed

    Toda, Noboru; Okamura, Tomio

    2015-06-01

    Cerebral vascular resistance and blood flow were widely considered to be regulated solely by tonic innervation of vasoconstrictor adrenergic nerves. However, pieces of evidence suggesting that parasympathetic nitrergic nerve activation elicits vasodilatation in dog and monkey cerebral arteries were found in 1990. Nitric oxide (NO) as a neurotransmitter liberated from parasympathetic postganglionic neurons decreases cerebral vascular tone and resistance and increases cerebral blood flow, which overcome vasoconstrictor responses to norepinephrine liberated from adrenergic nerves. Functional roles of nitrergic vasodilator nerves are found also in peripheral vasculature, including pulmonary, renal, mesenteric, hepatic, ocular, uterine, nasal, skeletal muscle, and cutaneous arteries and veins; however, adrenergic nerve-induced vasoconstriction is evidently greater than nitrergic vasodilatation in these vasculatures. In coronary arteries, neurogenic NO-mediated vasodilatation is not clearly noted; however, vasodilatation is induced by norepinephrine released from adrenergic nerves that activates β1-adrenoceptors. Impaired actions of NO liberated from the endothelium and nitrergic neurons are suggested to participate in cerebral hypoperfusion, leading to brain dysfunction, like that in Alzheimer's disease. Nitrergic neural dysfunction participates in impaired circulation in peripheral organs and tissues and also in systemic blood pressure increase. NO and vasodilator peptides, as sensory neuromediators, are involved in neurogenic vasodilatation in the skin. Functioning of nitrergic vasodilator nerves is evidenced not only in a variety of mammals, including humans and monkeys, but also in non-mammals. The present review article includes recent advances in research on the functional importance of nitrergic nerves concerning the control of cerebral blood flow, as well as other regions, and vascular resistance. Although information is still insufficient, the nitrergic nerve

  19. A programmable sound processor for advanced hearing aid research.

    PubMed

    McDermott, H

    1998-03-01

    A portable sound processor has been developed to facilitate research on advanced hearing aids. Because it is based on a digital signal processing integrated circuit (Motorola DSP56001), it can readily be programmed to execute novel algorithms. Furthermore, the parameters of these algorithms can be adjusted quickly and easily to suit the specific hearing characteristics of users. In the processor, microphone signals are digitized to a precision of 12 bits at a sampling rate of approximately 12 kHz for input to the DSP device. Subsequently, processed samples are delivered to the earphone by a novel, fully-digital class-D driver. This driver provides the advantages of a conventional class-D amplifier (high maximum output, low power consumption, low distortion) without some of the disadvantages (such as the need for precise analog circuitry). In addition, a cochlear implant driver is provided so that the processor is suitable for hearing-impaired people who use an implant and an acoustic hearing aid together. To reduce the computational demands on the DSP device, and therefore the power consumption, a running spectral analysis of incoming signals is provided by a custom-designed switched-capacitor integrated circuit incorporating 20 bandpass filters. The complete processor is pocket-sized and powered by batteries. An example is described of its use in providing frequency-shaped amplification for aid users with severe hearing impairment. Speech perception tests confirmed that the processor performed significantly better than the subjects' own hearing aids, probably because the digital filter provided a frequency response generally closer to the optimum for each user than the simpler analog aids. PMID:9535523

  20. A programmable sound processor for advanced hearing aid research.

    PubMed

    McDermott, H

    1998-03-01

    A portable sound processor has been developed to facilitate research on advanced hearing aids. Because it is based on a digital signal processing integrated circuit (Motorola DSP56001), it can readily be programmed to execute novel algorithms. Furthermore, the parameters of these algorithms can be adjusted quickly and easily to suit the specific hearing characteristics of users. In the processor, microphone signals are digitized to a precision of 12 bits at a sampling rate of approximately 12 kHz for input to the DSP device. Subsequently, processed samples are delivered to the earphone by a novel, fully-digital class-D driver. This driver provides the advantages of a conventional class-D amplifier (high maximum output, low power consumption, low distortion) without some of the disadvantages (such as the need for precise analog circuitry). In addition, a cochlear implant driver is provided so that the processor is suitable for hearing-impaired people who use an implant and an acoustic hearing aid together. To reduce the computational demands on the DSP device, and therefore the power consumption, a running spectral analysis of incoming signals is provided by a custom-designed switched-capacitor integrated circuit incorporating 20 bandpass filters. The complete processor is pocket-sized and powered by batteries. An example is described of its use in providing frequency-shaped amplification for aid users with severe hearing impairment. Speech perception tests confirmed that the processor performed significantly better than the subjects' own hearing aids, probably because the digital filter provided a frequency response generally closer to the optimum for each user than the simpler analog aids.

  1. Advanced Low-Noise Research Fan Stage Design

    NASA Technical Reports Server (NTRS)

    Neubert, Robert; Bock, Larry; Malmborg, Eric; Owen-Peer, William

    1997-01-01

    This report describes the design of the Advanced Low-Noise Research Fan stage. The fan is a variable pitch design, which is designed at the cruise pitch condition. Relative to the cruise setting, the blade is closed at takeoff and opened for reverse thrust operation. The fan stage is a split flow design with fan exit guide vanes (FEGVs) and core stators. The fan stage design is combined with a nacelle and engine core duct to form a powered fan/nacelle subscale model. This model is intended for use in combined aerodynamic, acoustic, and structural testing in a wind tunnel. The fan has an outer diameter of 22 in. and a hub-to-tip of 0.426 in., which allows the use of existing NASA fan and cowl force balance and rig drive systems. The design parameters were selected to permit valid acoustic and aerodynamic comparisons with the Pratt & Whitney (P&W) 17- and 22-in. rigs previously tested under NASA contract. The fan stage design is described in detail. The results of the design axisymmetric and Navier-Stokes aerodynamic analysis are presented at the critical design conditions. The structural analysis of the fan rotor and attachment is included. The blade and attachment are predicted to have adequate low-cycle fatigue life and an acceptable operating range without resonant stress or flutter. The stage was acoustically designed with airfoil counts in the FEGV and core stator to minimize noise. A fan/FEGV tone analysis developed separately under NASA contract was used to determine the optimum airfoil counts. The fan stage was matched to the existing nacelle, designed under the previous P&W low-noise contract, to form a fan/nacelle model for wind tunnel testing. It is an axisymmetric nacelle for convenience in testing and analysis. Previous testing confirmed that the nacelle performed as required at various aircraft operating conditions.

  2. Advances in Isolation Methods for Spermatogonial Stem Cells.

    PubMed

    Zhang, Rui; Sun, Jin; Zou, Kang

    2016-02-01

    Stem cell research has led to many remarkable achievements in recent years, but progress in the study of spermatogonial stem cells (SSCs) has been relatively slow, partly due to the slow development of techniques for spermatogonial stem cell isolation. The major accomplishments of SSC sorting and identification occurred approximately 10 years ago, and since that time, these techniques have been widely used without major improvements. In this article, we briefly introduce the biological properties of SSCs before reviewing the development of sorting techniques for SSCs in the past decades. We then summarize recent achievements in SSC sorting and finally discuss the advantages and disadvantages of SSC isolation methods, to provide new insight into techniques and research related to spermatogonial stem cells and promote the development of reproductive biology.

  3. [Research advances on medical genetics in China in 2015].

    PubMed

    Li, Yuanfeng; Han, Yubo; Cao, Pengbo; Meng, Jinfeng; Li, Haibei; Qin, Geng; Zhang, Feng; Jin, Guangfu; Yang, Yong; Wu, Lingqian; Ping, Jie; Zhou, Gangqiao

    2016-05-01

    Steady progress has been achieved in the medical genetics in China in 2015, as numerous original researches were published in the world's leading journals. Chinese scientists have made significant contributions to various fields of medical genetics, such as pathogenicity of rare diseases, predisposition of common diseases, somatic mutations of cancer, new technologies and methods, disease-related microRNAs (miRNAs), disease-related long non-coding RNAs (lncRNAs), disease-related competing endogenous RNAs (ceRNAs), disease-related RNA splicing and molecular evolution. In these fields, Chinese scientists have gradually formed the tendency, from common variants to rare variants, from single omic analyses to multipleomics integration analyses, from genetic discovery to functional confirmation, from basic research to clinical application. Meanwhile, the findings of Chinese scientists have been drawn great attentions of international peers. This review aims to provide an overall picture of the front in Chinese medical genetics, and highlights the important findings and their research strategy.

  4. Advanced Fluid Research On Drag reduction In Turbulence Experiments -- AFRODITE

    NASA Astrophysics Data System (ADS)

    Fransson, Jens H. M.

    2011-11-01

    A hot topic in today's debate on global warming is drag reduction in aeronautics. The most beneficial concept for drag reduction is to maintain the major portion of the airfoil laminar. Estimations show that the potential drag reduction can be as much as 15%, which would give a significant reduction of NOx and CO emissions in the atmosphere considering that the number of aircraft take offs, only in the EU, is over 19 million per year. In previous tuned wind tunnel measurements it has been shown that roughness elements can be used to sensibly delay transition to turbulence. Fransson et al. 2006 Phys. Rev. Lett. 96, 064501. The result is revolutionary, since the common belief has been that surface roughness causes earlier transition and in turn increases the drag, and is a proof of concept of the passive control method per se. The beauty with a passive control technique is that no external energy has to be added to the flow system in order to perform the control, instead one uses the existing energy in the flow. Within the research programme AFRODITE, funded by ERC, we will take this passive control method to the next level by making it twofold, more persistent and more robust. Financial support from the European Research Council (ERC) is acknowledged.

  5. Quantifying hydrate solidification front advancing using method of characteristics

    NASA Astrophysics Data System (ADS)

    You, Kehua; DiCarlo, David; Flemings, Peter B.

    2015-10-01

    We develop a one-dimensional analytical solution based on the method of characteristics to explore hydrate formation from gas injection into brine-saturated sediments within the hydrate stability zone. Our solution includes fully coupled multiphase and multicomponent flow and the associated advective transport in a homogeneous system. Our solution shows that hydrate saturation is controlled by the initial thermodynamic state of the system and changed by the gas fractional flow. Hydrate saturation in gas-rich systems can be estimated by 1-cl0/cle when Darcy flow dominates, where cl0 is the initial mass fraction of salt in brine, and cle is the mass fraction of salt in brine at three-phase (gas, liquid, and hydrate) equilibrium. Hydrate saturation is constant, gas saturation and gas flux decrease, and liquid saturation and liquid flux increase with the distance from the gas inlet to the hydrate solidification front. The total gas and liquid flux is constant from the gas inlet to the hydrate solidification front and decreases abruptly at the hydrate solidification front due to gas inclusion into the hydrate phase. The advancing velocity of the hydrate solidification front decreases with hydrate saturation at a fixed gas inflow rate. This analytical solution illuminates how hydrate is formed by gas injection (methane, CO2, ethane, propane) at both the laboratory and field scales.

  6. Research Advances: Nitric Oxide Synthase Reduces Cr(VI); The Chemistry of Popcorn: It's All About "Pop-Ability"; Nanotubes May Help Heal Broken Bones; New Method Unites Organic Materials and Nanotechnology

    NASA Astrophysics Data System (ADS)

    King, Angela G.

    2005-12-01

    An enzyme can reduce chromium ions and increase toxicity. Chemistry may reduce the number of unpopped kernels. Nanotubes provide scaffolding for bone growth. A new method will aid fabrication of drug-delivery agents.

  7. Status and future directions for advanced accelerator research - conventional and non-conventional collider concepts

    SciTech Connect

    Siemann, R.H.

    1997-01-01

    The relationship between advanced accelerator research and future directions for particle physics is discussed. Comments are made about accelerator research trends in hadron colliders, muon colliders, and e{sup +}3{sup {minus}} linear colliders.

  8. Qualitative Research Methods in Education and Educational Technology. Research Methods for Educational Technology

    ERIC Educational Resources Information Center

    Willis, Jerry W.

    2008-01-01

    "Qualitative Research Methods in Education and Educational Technology" was written for students and scholars interested in exploring the many qualitative methods developed over the last 50 years in the social sciences. The book does not stop, however, at the boundaries of the social sciences. Social scientists now consume and use research methods…

  9. Development and Applications of Advanced Electronic Structure Methods

    NASA Astrophysics Data System (ADS)

    Bell, Franziska

    This dissertation contributes to three different areas in electronic structure theory. The first part of this thesis advances the fundamentals of orbital active spaces. Orbital active spaces are not only essential in multi-reference approaches, but have also become of interest in single-reference methods as they allow otherwise intractably large systems to be studied. However, despite their great importance, the optimal choice and, more importantly, their physical significance are still not fully understood. In order to address this problem, we studied the higher-order singular value decomposition (HOSVD) in the context of electronic structure methods. We were able to gain a physical understanding of the resulting orbitals and proved a connection to unrelaxed natural orbitals in the case of Moller-Plesset perturbation theory to second order (MP2). In the quest to find the optimal choice of the active space, we proposed a HOSVD for energy-weighted integrals, which yielded the fastest convergence in MP2 correlation energy for small- to medium-sized active spaces to date, and is also potentially transferable to coupled-cluster theory. In the second part, we studied monomeric and dimeric glycerol radical cations and their photo-induced dissociation in collaboration with Prof. Leone and his group. Understanding the mechanistic details involved in these processes are essential for further studies on the combustion of glycerol and carbohydrates. To our surprise, we found that in most cases, the experimentally observed appearance energies arise from the separation of product fragments from one another rather than rearrangement to products. The final chapters of this work focus on the development, assessment, and application of the spin-flip method, which is a single-reference approach, but capable of describing multi-reference problems. Systems exhibiting multi-reference character, which arises from the (near-) degeneracy of orbital energies, are amongst the most

  10. [Research advances in anaerobic co-digestion of biogas fermentation substrates].

    PubMed

    Dong, Fei-Qing; Li, Xia; Lu, Jian-Bo

    2012-07-01

    With global climate change, more and more attention has been paid to the development of bio-energy. Biogas fermentation, as a fairly mature technology of bio-matter energy transformation, has received considerable attention and experienced much development. How to improve the efficiency of biogas fermentation and promote its industrialization is a pressing issue. Anaerobic co-digestion is a simple, low-cost, and high-efficiency method for enhancing the efficiency of biogas fermentation, and received increasing attention from related researchers. This paper summarized the characteristics of various fermentation substrates, reviewed the research advances in the co-digestion of animal manure, sewage sludge, and industrial waste, with the focus on the advantages of co-digestion and the factors affecting the rate and efficiency of co-digestion, and prospected the future research of co-digestion and its application, aimed to provide theoretical guidance for the promotion and application of co-digestion techniques.

  11. Advanced Methods for Aircraft Engine Thrust and Noise Benefits: Nozzle-Inlet Flow Analysis

    NASA Technical Reports Server (NTRS)

    Morgan, Morris H., III; Gilinsky, Mikhail M.

    2004-01-01

    In this project on the first stage (2000-Ol), we continued to develop the previous joint research between the Fluid Mechanics and Acoustics Laboratory (FM&AL) at Hampton University (HU) and the Jet Noise Team (JNT) at the NASA Langley Research Center (NASA LaRC). At the second stage (2001-03), FM&AL team concentrated its efforts on solving of problems of interest to Glenn Research Center (NASA GRC), especially in the field of propulsion system enhancement. The NASA GRC R&D Directorate and LaRC Hyper-X Program specialists in a hypersonic technology jointly with the FM&AL staff conducted research on a wide region of problems in the propulsion field as well as in experimental testing and theoretical and numerical simulation analyses for advanced aircraft and rocket engines. The last year the Hampton University School of Engineering & Technology was awarded the NASA grant, for creation of the Aeropropulsion Center, and the FM&AL is a key team of the project fulfillment responsible for research in Aeropropulsion and Acoustics (Pillar I). This work is supported by joint research between the NASA GRC/ FM&AL and the Institute of Mechanics at Moscow State University (IMMSU) in Russia under a CRDF grant. The main areas of current scientific interest of the FM&AL include an investigation of the proposed and patented advanced methods for aircraft engine thrust and noise benefits. This is the main subject of our other projects, of which one is presented. The last year we concentrated our efforts to analyze three main problems: (a) new effective methods fuel injection into the flow stream in air-breathing engines; (b) new re-circulation method for mixing, heat transfer and combustion enhancement in propulsion systems and domestic industry application; (c) covexity flow The research is focused on a wide regime of problems in the propulsion field as well as in experimental testing and theoretical and numerical simulation analyses for advanced aircraft and rocket engines (see, for

  12. [Research advances in the responses of carbohydrates in grassland plants to environmental stress].

    PubMed

    Gao, Ying-Zhi; Wang, Yan-Hua; Wang, Jing-Ting; Liu, Ju-Shan; Wang, De-Li

    2009-11-01

    Carbohydrates are the main energy materials for plant metabolic activities. Enough carbohydrates stored in roots are necessary for plant re-growth, its tolerance against environmental stress, and the maintenance of grassland ecosystem stability. This paper summarized the influences of grazing, nitrogen fertilization, salt stress, drought, low temperature, and low oxygen stress on the carbohydrates in grassland plants, and introduced the advanced methods of measuring root carbohydrates. It was suggested that the research emphasis in the future should be paid on the relationships between root soluble sugar components and root physio-ecological functions.

  13. Advanced Research Training in Human Geography: The Scottish Experience

    ERIC Educational Resources Information Center

    Gwanzura-Ottemoeller, Fungisai; Hopkins, Peter; Lorimer, Hayden; Philip, Lorna J.

    2005-01-01

    Formal research training is integral to research degrees in human geography completed in UK higher education institutions today. The Economic and Social Research Council (ESRC) has been the driving force behind the formalization of research training. Arguably less well known among the ESRC research training recommendations is the stipulation that…

  14. Narrative methods in quality improvement research

    PubMed Central

    Greenhalgh, T; Russell, J; Swinglehurst, D

    2005-01-01

    

 This paper reviews and critiques the different approaches to the use of narrative in quality improvement research. The defining characteristics of narrative are chronology (unfolding over time); emplotment (the literary juxtaposing of actions and events in an implicitly causal sequence); trouble (that is, harm or the risk of harm); and embeddedness (the personal story nests within a particular social, historical and organisational context). Stories are about purposeful action unfolding in the face of trouble and, as such, have much to offer quality improvement researchers. But the quality improvement report (a story about efforts to implement change), which is common, must be distinguished carefully from narrative based quality improvement research (focused systematic enquiry that uses narrative methods to generate new knowledge), which is currently none. We distinguish four approaches to the use of narrative in quality improvement research—narrative interview; naturalistic story gathering; organisational case study; and collective sense-making—and offer a rationale, describe how data can be collected and analysed, and discuss the strengths and limitations of each using examples from the quality improvement literature. Narrative research raises epistemological questions about the nature of narrative truth (characterised by sense-making and emotional impact rather than scientific objectivity), which has implications for how rigour should be defined (and how it might be achieved) in this type of research. We offer some provisional guidance for distinguishing high quality narrative research in a quality improvement setting from other forms of narrative account such as report, anecdote, and journalism. PMID:16326792

  15. Comparative effectiveness research: Policy context, methods development and research infrastructure.

    PubMed

    Tunis, Sean R; Benner, Joshua; McClellan, Mark

    2010-08-30

    Comparative effectiveness research (CER) has received substantial attention as a potential approach for improving health outcomes while lowering costs of care, and for improving the relevance and quality of clinical and health services research. The Institute of Medicine defines CER as 'the conduct and synthesis of systematic research comparing different interventions and strategies to prevent, diagnose, treat, and monitor health conditions. The purpose of this research is to inform patients, providers, and decision-makers, responding to their expressed needs, about which interventions are most effective for which patients under specific circumstances.' Improving the methods and infrastructure for CER will require sustained attention to the following issues: (1) Meaningful involvement of patients, consumers, clinicians, payers, and policymakers in key phases of CER study design and implementation; (2) Development of methodological 'best practices' for the design of CER studies that reflect decision-maker needs and balance internal validity with relevance, feasibility and timeliness; and (3) Improvements in research infrastructure to enhance the validity and efficiency with which CER studies are implemented. The approach to addressing each of these issues should be informed by the understanding that the primary purpose of CER is to help health care decision makers make informed clinical and health policy decisions.

  16. Learning from Research on Teaching: Perspective, Methodology, and Representation. Advances in Research on Teaching. Volume 11

    ERIC Educational Resources Information Center

    Brophy, Jere, Ed.; Pinnegar, Stefinee, Ed.

    2005-01-01

    This volume is designed to accomplish three primary purposes: (1) illustrate a variety of qualitative methods that researchers have used to study teaching and teacher education; (2) assess the affordances and constraints of these methods and the ways that they focus and shape explorations of teaching; and (3) illuminate representative questions…

  17. Research and development on the application of advanced control technologies to advanced nuclear reactor systems: A US national perspective

    SciTech Connect

    White, J.D.; Monson, L.R.; Carrol, D.G.; Dayal, Y.; Argonne National Lab., IL; General Electric Co., San Jose, CA )

    1989-01-01

    Control system designs for nuclear power plants are becoming more advanced through the use of digital technology and automation. This evolution is taking place because of: (1) the limitations in analog based control system performance and maintenance and availability and (2) the promise of significant improvement in plant operation and availability due to advances in digital and other control technologies. Digital retrofits of control systems in US nuclear plants are occurring now. Designs of control and protection systems for advanced LWRs are based on digital technology. The use of small inexpensive, fast, large-capacity computers in these designs is the first step of an evolutionary process described in this paper. Under the sponsorship of the US Department of Energy (DOE), Oak Ridge National Laboratory, Argonne National Laboratory, GE Nuclear Energy and several universities are performing research and development in the application of advances in control theory, software engineering, advanced computer architectures, artificial intelligence, and man-machine interface analysis to control system design. The target plant concept for the work described in this paper is the Power Reactor Inherently Safe Module reactor (PRISM), an advanced modular liquid metal reactor concept. This and other reactor designs which provide strong passive responses to operational upsets or accidents afford good opportunities to apply these advances in control technology. 18 refs., 5 figs.

  18. Meeting Reports for 2013: Recent Advances in Breath Biomarker Research

    EPA Science Inventory

    This article reports the efforts of the breath research community affiliated with the International Association of Breath Research (IABR) in disseminating research results in high profile technical meetings in the United States (US). Specifically, we describe presentations at a ...

  19. [Research advances in macroinvertebrate ecology of the stream hyporheic zone].

    PubMed

    Zhang, Yue-Wei; Yuan, Xing-Zhong; Liu, Hong; Ren, Hai-Qing

    2014-11-01

    The stream hyporheic zone is an ecotone of surface water-ground water interactions, which is rich in biodiversity, and is an important component of stream ecosystem. The macroinvertebrates, which are at the top of food webs in the hyporheic zone to directly influence the matter and energy dynamics of the hyporheic zone, and are potential indicators of river ecological health to adjust the function of environment purification and ecological buffer. The macroinvertebrates in the hyporheic zone are divided into three categories: stygoxenes, stygophiles and stygobites. The key factors which influenced macroinvertebrates distribution in the hyporheic zone are physical size of interstitial spaces, interstitial current velocity, dissolved oxygen (DO), water temperature, available organic matter, hydraulic conductivity and hydraulic retention time. A suitable sampling method should be used for diverse research purposes in the special ecological interface. In the future, some necessary researches should focus on the life-history and life history strategy of the macroinvertebrates in the hyporheic zone, the quantitative analysis on the matter and energy dynamics in the ecological system of stream, the assessment systems of river ecological health based on the macroinvertebrates of the stream hyporheic zone, and the ecological significance of the hyporheic zone as a refuge for distribution and evolution of the macroinvertebrates.

  20. Technologic Advances in Aural Rehabilitation: Applications and Innovative Methods of Service Delivery

    PubMed Central

    Sweetow, Robert W.; Sabes, Jennifer Henderson

    2007-01-01

    The level of interest in aural rehabilitation has increased recently, both in clinical use and in research presentations and publications. Advances in aural rehabilitation have seen previous techniques such as speech tracking and analytic auditory training reappear in computerized forms. These new delivery methods allow for a consistent, cost-effective, and convenient training program. Several computerized aural rehabilitation programs for hearing aid wearers and cochlear implant recipients have recently been developed and were reported on at the 2006 State of the Science Conference of the Rehabilitation Engineering Research Center on Hearing Enhancement at Gallaudet University. This article reviews these programs and outlines the similarities and differences in their design. Another promising area of aural rehabilitation research is the use of pharmaceuticals in the rehabilitation process. The results from a study of the effect of d-amphetamine in conjunction with intensive aural rehabilitation with cochlear implant patients are also described. PMID:17494876