Science.gov

Sample records for advanced three-dimensional computational

  1. Effect of surgical mandibular advancement on pharyngeal airway dimensions: a three-dimensional computed tomography study.

    PubMed

    Kochar, G D; Chakranarayan, A; Kohli, S; Kohli, V S; Khanna, V; Jayan, B; Chopra, S S; Verma, M

    2016-05-01

    The aim of this study was to quantify the changes in pharyngeal airway space (PAS) in patients with a skeletal class II malocclusion managed by bilateral sagittal split ramus osteotomy for mandibular advancement, using three-dimensional (3D) registration. The sample comprised 16 patients (mean age 21.69±2.80 years). Preoperative (T0) and postoperative (T1) computed tomography scans were recorded. Linear, cross-sectional area (CSA), and volumetric parameters of the velopharynx, oropharynx, and hypopharynx were evaluated. Parameters were compared with paired samples t-tests. Highly significant changes in dimension were measured in both sagittal and transverse planes (P<0.001). CSA measurements increased significantly between T0 and T1 (P<0.001). A significant increase in PAS volume was found at T1 compared with T0 (P<0.001). The changes in PAS were quantified using 3D reconstruction. Along the sagittal and transverse planes, the greatest increase was seen in the oropharynx (12.16% and 11.50%, respectively), followed by hypopharynx (11.00% and 9.07%) and velopharynx (8.97% and 6.73%). CSA increased by 41.69%, 34.56%, and 28.81% in the oropharynx, hypopharynx, and velopharynx, respectively. The volumetric increase was greatest in the oropharynx (49.79%) and least in the velopharynx (38.92%). These established quantifications may act as a useful guide for clinicians in the field of dental sleep medicine.

  2. Advanced three-dimensional dynamic analysis by boundary element methods

    NASA Technical Reports Server (NTRS)

    Banerjee, P. K.; Ahma, S.

    1985-01-01

    Advanced formulations of boundary element method for periodic, transient transform domain and transient time domain solution of three-dimensional solids have been implemented using a family of isoparametric boundary elements. The necessary numerical integration techniques as well as the various solution algorithms are described. The developed analysis has been incorporated in a fully general purpose computer program BEST3D which can handle up to 10 subregions. A number of numerical examples are presented to demonstrate the accuracy of the dynamic analyses.

  3. Advanced Three-Dimensional Display System

    NASA Technical Reports Server (NTRS)

    Geng, Jason

    2005-01-01

    A desktop-scale, computer-controlled display system, initially developed for NASA and now known as the VolumeViewer(TradeMark), generates three-dimensional (3D) images of 3D objects in a display volume. This system differs fundamentally from stereoscopic and holographic display systems: The images generated by this system are truly 3D in that they can be viewed from almost any angle, without the aid of special eyeglasses. It is possible to walk around the system while gazing at its display volume to see a displayed object from a changing perspective, and multiple observers standing at different positions around the display can view the object simultaneously from their individual perspectives, as though the displayed object were a real 3D object. At the time of writing this article, only partial information on the design and principle of operation of the system was available. It is known that the system includes a high-speed, silicon-backplane, ferroelectric-liquid-crystal spatial light modulator (SLM), multiple high-power lasers for projecting images in multiple colors, a rotating helix that serves as a moving screen for displaying voxels [volume cells or volume elements, in analogy to pixels (picture cells or picture elements) in two-dimensional (2D) images], and a host computer. The rotating helix and its motor drive are the only moving parts. Under control by the host computer, a stream of 2D image patterns is generated on the SLM and projected through optics onto the surface of the rotating helix. The system utilizes a parallel pixel/voxel-addressing scheme: All the pixels of the 2D pattern on the SLM are addressed simultaneously by laser beams. This parallel addressing scheme overcomes the difficulty of achieving both high resolution and a high frame rate in a raster scanning or serial addressing scheme. It has been reported that the structure of the system is simple and easy to build, that the optical design and alignment are not difficult, and that the

  4. Three-dimensional thermal-hydraulic analysis of an advanced liquid metal reactor design by the COMMIX computer code

    SciTech Connect

    Shin, Y.W.

    1991-01-01

    The emphasis in the development of advanced liquid metal reactors (LMRs) is on inherent safety and economics. One such feature is the adoption of thermal radiation and natural-convection cooling of the reactor to handle decay heat following a reactor shutdown. The decay heat removal feature of the LMR design under investigation here involves an in-vessel overflow of hot-pool sodium next to the reactor vessel (RV) in such a way that in the event of a reactor heat-up due to decay heat, the RV temperature is elevated and thereby the rate of heat removal from the reactor to the ambient air is increased. The purpose is to limit the temperature rise due to the decay heat. The objective of this study is to evaluate the performance of the simple passive decay heat removal feature of an advanced LMR design based on radiation and natural convection. The evaluation was carried out by performing calculations using the COMMIX Code for two cases, one with the passive heat removal features and the other without the features, and comparing the results. 2 refs., 6 figs., 1 tab.

  5. Computer-Generated, Three-Dimensional Character Animation.

    ERIC Educational Resources Information Center

    Van Baerle, Susan Lynn

    This master's thesis begins by discussing the differences between 3-D computer animation of solid three-dimensional, or monolithic, objects, and the animation of characters, i.e., collections of movable parts with soft pliable surfaces. Principles from two-dimensional character animation that can be transferred to three-dimensional character…

  6. Three-dimensional registration of synchrotron radiation-based micro-computed tomography images with advanced laboratory micro-computed tomography data from murine kidney casts

    NASA Astrophysics Data System (ADS)

    Thalmann, Peter; Hieber, Simone E.; Schulz, Georg; Deyhle, Hans; Khimchenko, Anna; Kurtcuoglu, Vartan; Olgac, Ufuk; Marmaras, Anastasios; Kuo, Willy; Meyer, Eric P.; Beckmann, Felix; Herzen, Julia; Ehrbar, Stefanie; Müller, Bert

    2014-09-01

    Malfunction of oxygen regulation in kidney and liver may lead to the pathogenesis of chronic diseases. The underlying mechanisms are poorly understood. In kidney, it is hypothesized that renal gas shunting from arteries to veins eliminates excess oxygen. Such shunting is highly dependent on the structure of the renal vascular network. The vascular tree has so far not been quantified under maintenance of its connectivity as three-dimensional imaging of the vessel tree down to the smallest capillaries, which in mouse model are smaller than 5 μm in diameter, is a challenging task. An established protocol uses corrosion casts and applies synchrotron radiation-based micro-computed tomography (SRμCT), which provides the desired spatial resolution with the necessary contrast. However, SRμCT is expensive and beamtime access is limited. We show here that measurements with a phoenix nanotomrm (General Electric, Wunstorf, Germany) can provide comparable results to those obtained with SRμCT, except for regions with small vessel structures, where the signal-to-noise level was significantly reduced. For this purpose the nanotom®m measurement was compared with its corresponding measurement acquired at the beamline P05 at PETRA III at DESY, Hamburg, Germany.

  7. Three-Dimensional Computational Fluid Dynamics

    SciTech Connect

    Haworth, D.C.; O'Rourke, P.J.; Ranganathan, R.

    1998-09-01

    Computational fluid dynamics (CFD) is one discipline falling under the broad heading of computer-aided engineering (CAE). CAE, together with computer-aided design (CAD) and computer-aided manufacturing (CAM), comprise a mathematical-based approach to engineering product and process design, analysis and fabrication. In this overview of CFD for the design engineer, our purposes are three-fold: (1) to define the scope of CFD and motivate its utility for engineering, (2) to provide a basic technical foundation for CFD, and (3) to convey how CFD is incorporated into engineering product and process design.

  8. Three-dimensional external flow computations using prismatic grid

    NASA Astrophysics Data System (ADS)

    Nakahashi, Kazuhiro

    1992-12-01

    A new approach to compute external viscous flows around three dimensional configurations is proposed. A prismatic grid is used where the three dimensional surface is covered by triangles similar to the unstructured grid. The direction away from the body surface is structured so as to achieve efficient and accurate computations for high Reynolds number viscous flows. The prismatic grid is generated by a newly developed marching-type procedure in which grid spacings are controlled by a variational method. The capability of the method is demonstrated by applying it to a viscous flow computation around a complete aircraft configuration.

  9. New advances in three dimensional transient electromagnetic inversion

    SciTech Connect

    Newman, Gregory A.; Commer, Michael

    2004-06-16

    Inversion of transient electromagnetic (TEM) data sets to image the subsurface three-dimensional (3-D) electrical conductivity and magnetic permeability properties can be done directly in the time domain. The technique, first introduced by Wang et al. (1994) for causal and diffusive electromagnetic fields and subsequently implemented by Zhdanov and Portniaguine (1997) in the framework of iterative migration, is based upon imaging methods originally developed for seismic wavefields (Claerbout, 1971; Tarantola, 1984). In this paper we advance the original derivations of Wang et al. (1994) and Zhdanov and Portniaguine (1997) to treat non-causal TEM fields, as well as correct a flaw in the theory for treatment of magnetic field data. Our 3D imaging scheme is based on a conjugate-gradient search for the minimum of an error functional involving EM measurements governed by Maxwell's equations without displacement currents. Treatment for magnetic field, voltage (time derivative of the magnetic field) and electric field data are given. The functional can be computed by propagating the data errors back into the model in reverse time along with a DC field, sourced by the integrated data errors over the measurement time range. By correlating these fields, including the time-integrated back-propagated fields, with the corresponding incident field and its initial value at each image point, efficient computational forms for the gradients are developed. The forms of the gradients allow for additional efficiencies when voltage and electric field data are inverted. In such instances the combined data errors can be back-propagated jointly, significantly reducing the computation time required to solve the inverse problem. The inversion algorithm is applied to the long offset transient electromagnetic measurement (LOTEM) configuration thereby demonstrating its capability in inverting non-causal field measurements of electric field and voltage, sourced by a grounded wire, over complex

  10. Three-dimensional surface reconstruction for industrial computed tomography

    NASA Technical Reports Server (NTRS)

    Vannier, M. W.; Knapp, R. H.; Gayou, D. E.; Sammon, N. P.; Butterfield, R. L.; Larson, J. W.

    1985-01-01

    Modern high resolution medical computed tomography (CT) scanners can produce geometrically accurate sectional images of many types of industrial objects. Computer software has been developed to convert serial CT scans into a three-dimensional surface form, suitable for display on the scanner itself. This software, originally developed for imaging the skull, has been adapted for application to industrial CT scanning, where serial CT scans thrrough an object of interest may be reconstructed to demonstrate spatial relationships in three dimensions that cannot be easily understood using the original slices. The methods of three-dimensional reconstruction and solid modeling are reviewed, and reconstruction in three dimensions from CT scans through familiar objects is demonstrated.

  11. Three-dimensional terahertz computed tomography of human bones.

    PubMed

    Bessou, Maryelle; Chassagne, Bruno; Caumes, Jean-Pascal; Pradère, Christophe; Maire, Philippe; Tondusson, Marc; Abraham, Emmanuel

    2012-10-01

    Three-dimensional terahertz computed tomography has been used to investigate dried human bones such as a lumbar vertebra, a coxal bone, and a skull, with a direct comparison with standard radiography. In spite of lower spatial resolution compared with x-ray, terahertz imaging clearly discerns a compact bone from a spongy one, with strong terahertz absorption as shown by additional terahertz time-domain transmission spectroscopy.

  12. Three dimensional flow computations in a turbine scroll

    NASA Technical Reports Server (NTRS)

    Hamed, A.; Ghantous, C. A.

    1982-01-01

    The compressible three dimensional inviscid flow in the scroll and vaneless nozzle of radial inflow turbines is analyzed. A FORTRAN computer program for the numerical solution of this complex flow field using the finite element method is presented. The program input consists of the mass flow rate and stagnation conditions at the scroll inlet and of the finite element discretization parameters and nodal coordinates. The output includes the pressure, Mach number and velocity magnitude and direction at all the nodal points.

  13. Computational Study of Colloidal Droplet Interactions with Three Dimensional Structures

    DTIC Science & Technology

    2015-05-18

    SECURITY CLASSIFICATION OF: The colloidal droplet spreading on and sorption into a porous medium is important to 3D printing technology. In this study... colloidal fluid distribution in the porous structure after sorption of single/multiple droplets in powder beds. The spreading of the droplet on the surface...Feb-2015 Approved for Public Release; Distribution Unlimited Final Report: Computational Study of Colloidal Droplet Interactions with Three Dimensional

  14. Three-dimensional time dependent computation of turbulent flow

    NASA Technical Reports Server (NTRS)

    Kwak, D.; Reynolds, W. C.; Ferziger, J. H.

    1975-01-01

    The three-dimensional, primitive equations of motion are solved numerically for the case of isotropic box turbulence and the distortion of homogeneous turbulence by irrotational plane strain at large Reynolds numbers. A Gaussian filter is applied to governing equations to define the large scale field. This gives rise to additional second order computed scale stresses (Leonard stresses). The residual stresses are simulated through an eddy viscosity. Uniform grids are used, with a fourth order differencing scheme in space and a second order Adams-Bashforth predictor for explicit time stepping. The results are compared to the experiments and statistical information extracted from the computer generated data.

  15. Volumetric three-dimensional computed tomographic evaluation of the upper airway in patients with obstructive sleep apnoea syndrome treated by maxillomandibular advancement.

    PubMed

    Bianchi, Alberto; Betti, Enrico; Tarsitano, Achille; Morselli-Labate, Antonio Maria; Lancellotti, Lorenzo; Marchetti, Claudio

    2014-11-01

    Obstructive sleep apnoea syndrome is the periodic reduction or cessation of airflow during sleep together with daytime sleepiness. Its diagnosis requires polysomnographic evidence of 5 or more episodes of apnoea or hypopnoea/hour of sleep (apnoea/hypopnoea index, AHI). Volumetric 3-dimensional computed tomographic (CT) reconstruction enables the accurate measurement of the volume of the airway. Nasal continuous positive airway pressure (CPAP) is the conventional non-surgical treatment for patients with severe disease. Operations on the soft tissues that are currently available give success rates of only 40%-60%. Maxillomandibular advancement is currently the most effective craniofacial surgical technique for the treatment of obstructive sleep apnoea in adults. However, the appropriate distance for advancement has not been established. Expansion of the air-flow column volume did not result in an additional reduction in AHI, which raises the important issue of how much the maxillomandibular complex should be advanced to obtain an adequate reduction in AHI while avoiding the risks of overexpansion or underexpansion. We have shown that there is a significant linear relation between increased absolute upper airway volume after advancement and improvement in the AHI (p=0.013). However, increases in upper airway volume of 70% or more achieved no further reduction in the AHI, which suggests that the clinical improvement in AHI reaches a plateau, and renders further expansion unnecessary. This gives a new perspective to treatment based on the prediction of changes in volume, so the amount of sagittal advancement can be tailored in each case, which replaces the current standard of 1cm.

  16. Massively parallel finite element computation of three dimensional flow problems

    NASA Astrophysics Data System (ADS)

    Tezduyar, T.; Aliabadi, S.; Behr, M.; Johnson, A.; Mittal, S.

    1992-12-01

    The parallel finite element computation of three-dimensional compressible, and incompressible flows, with emphasis on the space-time formulations, mesh moving schemes and implementations on the Connection Machines CM-200 and CM-5 are presented. For computation of unsteady compressible and incompressible flows involving moving boundaries and interfaces, the Deformable-Spatial-Domain/Stabilized-Space-Time (DSD/SST) formulation that previously developed are employed. In this approach, the stabilized finite element formulations of the governing equations are written over the space-time domain of the problem; therefore, the deformation of the spatial domain with respect to time is taken into account automatically. This approach gives the capability to solve a large class of problems involving free surfaces, moving interfaces, and fluid-structure and fluid-particle interactions. By using special mesh moving schemes, the frequency of remeshing is minimized to reduce the projection errors involved in remeshing and also to increase the parallelization ease of the computations. The implicit equation systems arising from the finite element discretizations are solved iteratively by using the GMRES update technique with the diagonal and nodal-block-diagonal preconditioners. These formulations have all been implemented on the CM-200 and CM-5, and have been applied to several large-scale problems. The three-dimensional problems in this report were all computed on the CM-200 and CM-5.

  17. Three-dimensional protein structure prediction: Methods and computational strategies.

    PubMed

    Dorn, Márcio; E Silva, Mariel Barbachan; Buriol, Luciana S; Lamb, Luis C

    2014-10-12

    A long standing problem in structural bioinformatics is to determine the three-dimensional (3-D) structure of a protein when only a sequence of amino acid residues is given. Many computational methodologies and algorithms have been proposed as a solution to the 3-D Protein Structure Prediction (3-D-PSP) problem. These methods can be divided in four main classes: (a) first principle methods without database information; (b) first principle methods with database information; (c) fold recognition and threading methods; and (d) comparative modeling methods and sequence alignment strategies. Deterministic computational techniques, optimization techniques, data mining and machine learning approaches are typically used in the construction of computational solutions for the PSP problem. Our main goal with this work is to review the methods and computational strategies that are currently used in 3-D protein prediction.

  18. Three dimensional computer vision: Potential applications with curvature tracking

    SciTech Connect

    Sanford, Adam

    1996-05-01

    The purpose of this project is to develop a method of tracking data points for computer vision systems using curvature analysis. This is of particular importance to fellow researchers at the Lab, who have developed a markerless video computer vision system and are in need of such a method to track data points. A three dimensional viewing program was created to analyze the geometry of surface patches. Virtual surfaces were plotted and processed by the program to determine the Mean and Gaussian Curvature parameters for each point on the surface, thus defining each point`s surface geometry type. The same computer processes are then applied to each frame of data acquired by the computer vision system to find surface {open_quotes}landmarks{close_quotes} that hold constant curvature during motion. Preliminary results indicate that curvature analysis shows great promise and could solve the tracking dilemma faced by those in the field of markerless imaging systems.

  19. Three-Dimensional Computer Aided Design of a Vertical Winnower

    NASA Astrophysics Data System (ADS)

    Bao, Yumei; Lin, Saijia; Weng, Lijie

    The research states home and abroad of the winnowing technology and winnowers are reviewed in brief. For the air duct, the core component of the winnower, the relevant technical parameters in the winnowing process are calculated based on the winnowing principle. The three-dimensional computer aided design (3D-CAD) software Solidworks is applied. The designed vertical winnower is able to separate different raw materials by adjusting the air speed and has been put into practical production to separate the Chinese traditional medicine with high separating effect.

  20. Computation of three-dimensional turbulent shear flows in corners

    NASA Astrophysics Data System (ADS)

    Gorski, J. J.; Govindan, T. R.; Lakshminarayana, B.

    1983-07-01

    A numerical technique developed for the solution of the steady Navier-Stokes equations using a 'space marching' algorithm has been used to predict a complex, three-dimensional, turbulent flow. The scheme has been designed to calculate flows with a dominant flow direction, in three-dimensional geometries, and has been used successfully to predict laminar flows. This paper is concerned with the extension of this technique to calculate turbulent flows in the corner region of a wing-body junction using both algebraic eddy viscosity and K-epsilon turbulence models. Effects of different boundary conditions for the streamwise velocity, at a solid boundary, used in many turbulent flow computations are also considered. In the flow cases computed using a 'slip' boundary condition at solid boundaries, the K-epsilon model showed on distinct advantages over the simpler algebraic eddy viscosity model. However, the K-epsilon model provided much better results for the cases computed with the more realistic 'no slip' conditions.

  1. Three-dimensional gauging with stereo computer vision

    NASA Astrophysics Data System (ADS)

    Wong, Kam W.; Ke, Ying; Lew, Michael S.; Obaidat, Mohammed T.

    1991-09-01

    Three-dimensional gaging involves the measurement and mapping of 3-D surfaces. Gaging accuracy depends on measurement accuracy in the images, image scale, and stereo geometry. Multiple cameras are often needed to provide adequate stereoscopic coverage of the object. This paper reports on an automatic 3-D gaging system that is being developed at the University of Illinois at Urbana-Champaign. A portable 3-D target field, consisting of 198 targets each identified with a bar code, is used to determine the interior and exterior orientation parameters of each camera. Image-processing algorithms have been developed to identify conjugate image points in stereo pair of images, and the object-space coordinates of these points are computed by stereo intersection. Software has also been developed for analysis and data editing.

  2. Computations of Complex Three-Dimensional Turbulent Free Jets

    NASA Technical Reports Server (NTRS)

    Wilson, Robert V.; Demuren, Ayodeji O.

    1997-01-01

    Three-dimensional, incompressible turbulent jets with rectangular and elliptical cross-sections are simulated with a finite-difference numerical method. The full Navier- Stokes equations are solved at low Reynolds numbers, whereas at high Reynolds numbers filtered forms of the equations are solved along with a sub-grid scale model to approximate the effects of the unresolved scales. A 2-N storage, third-order Runge-Kutta scheme is used for temporary discretization and a fourth-order compact scheme is used for spatial discretization. Although such methods are widely used in the simulation of compressible flows, the lack of an evolution equation for pressure or density presents particular difficulty in incompressible flows. The pressure-velocity coupling must be established indirectly. It is achieved, in this study, through a Poisson equation which is solved by a compact scheme of the same order of accuracy. The numerical formulation is validated and the dispersion and dissipation errors are documented by the solution of a wide range of benchmark problems. Three-dimensional computations are performed for different inlet conditions which model the naturally developing and forced jets. The experimentally observed phenomenon of axis-switching is captured in the numerical simulation, and it is confirmed through flow visualization that this is based on self-induction of the vorticity field. Statistical quantities such as mean velocity, mean pressure, two-point velocity spatial correlations and Reynolds stresses are presented. Detailed budgets of the mean momentum and Reynolds stresses are presented. Detailed budgets of the mean momentum and Reynolds stress equations are presented to aid in the turbulence modeling of complex jets. Simulations of circular jets are used to quantify the effect of the non-uniform curvature of the non-circular jets.

  3. Advances in three-dimensional field analysis and evaluation of performance parameters of electrical machines

    NASA Astrophysics Data System (ADS)

    Sivasubramaniam, Kiruba

    This thesis makes advances in three dimensional finite element analysis of electrical machines and the quantification of their parameters and performance. The principal objectives of the thesis are: (1)the development of a stable and accurate method of nonlinear three-dimensional field computation and application to electrical machinery and devices; and (2)improvement in the accuracy of determination of performance parameters, particularly forces and torque computed from finite elements. Contributions are made in two general areas: a more efficient formulation for three dimensional finite element analysis which saves time and improves accuracy, and new post-processing techniques to calculate flux density values from a given finite element solution. A novel three-dimensional magnetostatic solution based on a modified scalar potential method is implemented. This method has significant advantages over the traditional total scalar, reduced scalar or vector potential methods. The new method is applied to a 3D geometry of an iron core inductor and a permanent magnet motor. The results obtained are compared with those obtained from traditional methods, in terms of accuracy and speed of computation. A technique which has been observed to improve force computation in two dimensional analysis using a local solution of Laplace's equation in the airgap of machines is investigated and a similar method is implemented in the three dimensional analysis of electromagnetic devices. A new integral formulation to improve force calculation from a smoother flux-density profile is also explored and implemented. Comparisons are made and conclusions drawn as to how much improvement is obtained and at what cost. This thesis also demonstrates the use of finite element analysis to analyze torque ripples due to rotor eccentricity in permanent magnet BLDC motors. A new method for analyzing torque harmonics based on data obtained from a time stepping finite element analysis of the machine is

  4. True Three-Dimensional Display Of Computer Data

    NASA Astrophysics Data System (ADS)

    Stover, Hank

    1983-04-01

    The display of data in three dimensions overcomes the ambiguity often found in two dimensional displays. It allows a truly objective examination of the display data while two-dimensional displays require a subjective interpretation of what might exist in the Z direction. SpaceGraph allows the display of data in a volume filling manner. The data can occupy a volume of 20 x 25 x 30 centimeters. The display volume is generated by observing the reflection of a CRT in a circular mirror. This mirror is flexed about a rubber hinge located on a concentric circle several inches from the edge. By exciting this assembly with a hi-fi woofer, the mirror is caused to vibrate and takes on concave and convex optical shapes thus varying the focal length. This varying focal length causes the image of the CRT to sweep out apparent distance in Z of about 30 centimeters. By plotting points on the CRT in X and Y, these points permit us to draw vectors which can describe a wide variety of three-dimensional objects, such as mechanical parts, molecules, mechanical subassemblies or total assemblies such as aircraft and ships. In the vector mode, SpaceGraph provides 23 meters of vectors which can appear in as many segments as required by the object being displayed. The three-dimensional display can also be used in a second mode which we will call the image mode. In this mode, X and Y are controlled to generate a raster much like one generated in a conventional home TV. While the raster is being swept, brightness is varied to provide an image in gray shades. As this process takes place, the Z is continuously swept by the mirror as in the vector mode and a volume filling image is created. This mode appears to be of particular interest to seismologists and in computer aided tomography. Other applications or views of science which appear promising for 3-D display are computer-aided design, air traffic control, ultra sound analysis and anti-submarine warfare.

  5. A three-dimensional computational model of collagen network mechanics.

    PubMed

    Lee, Byoungkoo; Zhou, Xin; Riching, Kristin; Eliceiri, Kevin W; Keely, Patricia J; Guelcher, Scott A; Weaver, Alissa M; Jiang, Yi

    2014-01-01

    Extracellular matrix (ECM) strongly influences cellular behaviors, including cell proliferation, adhesion, and particularly migration. In cancer, the rigidity of the stromal collagen environment is thought to control tumor aggressiveness, and collagen alignment has been linked to tumor cell invasion. While the mechanical properties of collagen at both the single fiber scale and the bulk gel scale are quite well studied, how the fiber network responds to local stress or deformation, both structurally and mechanically, is poorly understood. This intermediate scale knowledge is important to understanding cell-ECM interactions and is the focus of this study. We have developed a three-dimensional elastic collagen fiber network model (bead-and-spring model) and studied fiber network behaviors for various biophysical conditions: collagen density, crosslinker strength, crosslinker density, and fiber orientation (random vs. prealigned). We found the best-fit crosslinker parameter values using shear simulation tests in a small strain region. Using this calibrated collagen model, we simulated both shear and tensile tests in a large linear strain region for different network geometry conditions. The results suggest that network geometry is a key determinant of the mechanical properties of the fiber network. We further demonstrated how the fiber network structure and mechanics evolves with a local formation, mimicking the effect of pulling by a pseudopod during cell migration. Our computational fiber network model is a step toward a full biomechanical model of cellular behaviors in various ECM conditions.

  6. True Three-Dimensional Display Of Computer Generated Images

    NASA Astrophysics Data System (ADS)

    Stover, Hank; Fletcher, John

    1983-12-01

    The display of data in three dimensions overcomes the ambiguity often found in two dimensional displays. A truly objective examination of the display data is allowed while two-dimensional displays require a subjective interpretation of what might exist in the Z direction. Data can occupy a volume of 20 X 25 X 30 centimeters since SpaceGraph allows the display of data in a volume filling manner. The display volume is generated by observing the reflection of a CRT in a circular mirror. The mirror is flexed about a rubber hinge located on a concentric circle several inches from the edge. By exciting this assembly with a hi-fi woofer, the mirror is caused to vibrate and takes on concave and convex optical shapes thus varying the focal length. The varying focal length causes the image of the CRT to sweep out apparent distance in Z of about 30 centimeters. By plotting points on the CRT in X and Y, these points permit us to draw vectors which can describe a wide variety of three-dimensional objects, such as molecules, mechanical subassemblies or total assemblies such as aircraft and ships. In the vector mode, SpaceGraph provides 23 meters of vectors which can appear in as many segments as required by the object being displayed. The three-dimensional display can also be used in a second mode which can be called the image mode. In this mode, X and Y are controlled to generate a raster much like one generated in a conventional home TV. While the raster is being swept, brightness is varied to provide an image in gray shades. As this process takes place, the Z is continuously swept by the mirror as in the vector mode and a volume filling image is created. This mode appears to be of particular interest in computer-aided tomography and to seismologists. Computeraided design, ultra sound analysis, anti-submarine warfare and air traffic control are other applications or views of science which appear promising for 3-D displays.

  7. Integration of Computed Tomography and Three-Dimensional Echocardiography for Hybrid Three-Dimensional Printing in Congenital Heart Disease.

    PubMed

    Gosnell, Jordan; Pietila, Todd; Samuel, Bennett P; Kurup, Harikrishnan K N; Haw, Marcus P; Vettukattil, Joseph J

    2016-12-01

    Three-dimensional (3D) printing is an emerging technology aiding diagnostics, education, and interventional, and surgical planning in congenital heart disease (CHD). Three-dimensional printing has been derived from computed tomography, cardiac magnetic resonance, and 3D echocardiography. However, individually the imaging modalities may not provide adequate visualization of complex CHD. The integration of the strengths of two or more imaging modalities has the potential to enhance visualization of cardiac pathomorphology. We describe the feasibility of hybrid 3D printing from two imaging modalities in a patient with congenitally corrected transposition of the great arteries (L-TGA). Hybrid 3D printing may be useful as an additional tool for cardiologists and cardiothoracic surgeons in planning interventions in children and adults with CHD.

  8. Computer vision system for three-dimensional inspection

    NASA Astrophysics Data System (ADS)

    Penafiel, Francisco; Fernandez, Luis; Campoy, Pascual; Aracil, Rafael

    1994-11-01

    In the manufacturing process certain workpieces are inspected for dimensional measurement using sophisticated quality control techniques. During the operation phase, these parts are deformed due to the high temperatures involved in the process. The evolution of the workpieces structure is noticed on their dimensional modification. This evolution can be measured with a set of dimensional parameters. In this paper, a three dimensional automatic inspection of these parts is proposed. The aim is the measuring of some workpieces features through 3D control methods using directional lighting and a computer artificial vision system. The results of this measuring must be compared with the parameters obtained after the manufacturing process in order to determine the degree of deformation of the workpiece and decide whether it is still usable or not. Workpieces outside a predetermined specification range must be discarded and replaced by new ones. The advantage of artificial vision methods is based on the fact that there is no need to get in touch with the object to inspect. This makes feasible its use in hazardous environments, not suitable for human beings. A system has been developed and applied to the inspection of fuel assemblies in nuclear power plants. Such a system has been implemented in a very high level of radiation environment and operates in underwater conditions. The physical dimensions of a nuclear fuel assembly are modified after its operation in a nuclear power plant in relation to the original dimensions after its manufacturing. The whole system (camera, mechanical and illumination systems and the radioactive fuel assembly) is submerged in water for minimizing radiation effects and is remotely controlled by human intervention. The developed system has to inspect accurately a set of measures on the fuel assembly surface such as length, twists, arching, etc. The present project called SICOM (nuclear fuel assembly inspection system) is included into the R

  9. Computer Generated Holography as a Three-Dimensional Display Medium

    DTIC Science & Technology

    1990-12-01

    series of two dimensional images are reflected on an object screen resulting in an autostereoscopic , or true three dimensional, images. The advantages of...an attractive target to optimize. Jack Ritter has suggested a fast approximation to 3D Euclidean distance calculations (10:432). His methid uses no

  10. Surface Description and Motion Control for Animated Three Dimensional Computer Generated Characters.

    ERIC Educational Resources Information Center

    Hutchinson, Thomas Lloyd

    This study of the relationship of computer technology to character animation focuses on the advantages and constraints of developing three-dimensional characters for computer animation. Three different levels of the complexity involved in animating characters are examined: (1) a three-dimensional computer environment and simple motion within this…

  11. Three-dimensional hybrid grid generation using advancing front techniques

    NASA Technical Reports Server (NTRS)

    Steinbrenner, John P.; Noack, Ralph W.

    1995-01-01

    A new 3-dimensional hybrid grid generation technique has been developed, based on ideas of advancing fronts for both structured and unstructured grids. In this approach, structured grids are first generate independently around individual components of the geometry. Fronts are initialized on these structure grids, and advanced outward so that new cells are extracted directly from the structured grids. Employing typical advancing front techniques, cells are rejected if they intersect the existing front or fail other criteria When no more viable structured cells exist further cells are advanced in an unstructured manner to close off the overall domain, resulting in a grid of 'hybrid' form. There are two primary advantages to the hybrid formulation. First, generating blocks with limited regard to topology eliminates the bottleneck encountered when a multiple block system is used to fully encapsulate a domain. Individual blocks may be generated free of external constraints, which will significantly reduce the generation time. Secondly, grid points near the body (presumably with high aspect ratio) will still maintain a structured (non-triangular or tetrahedral) character, thereby maximizing grid quality and solution accuracy near the surface.

  12. The development of a three-dimensional partially elliptic flow computer program for combustor research

    NASA Technical Reports Server (NTRS)

    Pan, Y. S.

    1978-01-01

    A three dimensional, partially elliptic, computer program was developed. Without requiring three dimensional computer storage locations for all flow variables, the partially elliptic program is capable of predicting three dimensional combustor flow fields with large downstream effects. The program requires only slight increase of computer storage over the parabolic flow program from which it was developed. A finite difference formulation for a three dimensional, fully elliptic, turbulent, reacting, flow field was derived. Because of the negligible diffusion effects in the main flow direction in a supersonic combustor, the set of finite-difference equations can be reduced to a partially elliptic form. Only the pressure field was governed by an elliptic equation and requires three dimensional storage; all other dependent variables are governed by parabolic equations. A numerical procedure which combines a marching integration scheme with an iterative scheme for solving the elliptic pressure was adopted.

  13. Computation of three-dimensional mixed convective boundary layer flow

    NASA Technical Reports Server (NTRS)

    Gadepalli, Prashandt; Rahman, Muhammad M.

    1995-01-01

    The paper presents the numerical solution of heat and mass transfer during cross-flow (orthogonal) mixed convection. In this class of flow, a buoyancy-driven transport in the vertical direction and a forced convective flow in the horizontal direction results in a three-dimensional boundary layer structure adjacent to the plate. The rates of heat and mass transfer are determined by a combined influence of the two transport processes. The equations for the conservation of mass, momentum, energy, and species concentration were solved along with appropriate boundary conditions to determine the distributions of velocity components, temperature, and concentration across the thickness of the boundary layer at different locations on the plate. Results were expressed in dimensionless form using Reynolds number, Richardson number for heat transfer, Richardson number for mass transfer, Prandtl number, and Schmidt number as parameters. It was found that the transport is dominated by buoyancy at smaller vertical locations and at larger distances away from the forced convection leading edge. Effects of forced convection appeared to be very strong at smaller horizontal distances from the leading edge. The cross stream forced convection enhanced the rate of heat and mass transfer by a very significant amount.

  14. The three-dimensional Multi-Block Advanced Grid Generation System (3DMAGGS)

    NASA Technical Reports Server (NTRS)

    Alter, Stephen J.; Weilmuenster, Kenneth J.

    1993-01-01

    As the size and complexity of three dimensional volume grids increases, there is a growing need for fast and efficient 3D volumetric elliptic grid solvers. Present day solvers are limited by computational speed and do not have all the capabilities such as interior volume grid clustering control, viscous grid clustering at the wall of a configuration, truncation error limiters, and convergence optimization residing in one code. A new volume grid generator, 3DMAGGS (Three-Dimensional Multi-Block Advanced Grid Generation System), which is based on the 3DGRAPE code, has evolved to meet these needs. This is a manual for the usage of 3DMAGGS and contains five sections, including the motivations and usage, a GRIDGEN interface, a grid quality analysis tool, a sample case for verifying correct operation of the code, and a comparison to both 3DGRAPE and GRIDGEN3D. Since it was derived from 3DGRAPE, this technical memorandum should be used in conjunction with the 3DGRAPE manual (NASA TM-102224).

  15. The three-dimensional Multi-Block Advanced Grid Generation System (3DMAGGS)

    NASA Astrophysics Data System (ADS)

    Alter, Stephen J.; Weilmuenster, Kenneth J.

    1993-05-01

    As the size and complexity of three dimensional volume grids increases, there is a growing need for fast and efficient 3D volumetric elliptic grid solvers. Present day solvers are limited by computational speed and do not have all the capabilities such as interior volume grid clustering control, viscous grid clustering at the wall of a configuration, truncation error limiters, and convergence optimization residing in one code. A new volume grid generator, 3DMAGGS (Three-Dimensional Multi-Block Advanced Grid Generation System), which is based on the 3DGRAPE code, has evolved to meet these needs. This is a manual for the usage of 3DMAGGS and contains five sections, including the motivations and usage, a GRIDGEN interface, a grid quality analysis tool, a sample case for verifying correct operation of the code, and a comparison to both 3DGRAPE and GRIDGEN3D. Since it was derived from 3DGRAPE, this technical memorandum should be used in conjunction with the 3DGRAPE manual (NASA TM-102224).

  16. Microwave imaging for breast cancer detection: advances in three--dimensional image reconstruction.

    PubMed

    Golnabi, Amir H; Meaney, Paul M; Epstein, Neil R; Paulsen, Keith D

    2011-01-01

    Microwave imaging is based on the electrical property (permittivity and conductivity) differences in materials. Microwave imaging for biomedical applications is particularly interesting, mainly due to the fact that available range of dielectric properties for different tissues can provide important functional information about their health. Under the assumption that a 3D scattering problem can be reasonably represented as a simplified 2D model, one can take advantage of the simplicity and lower computational cost of 2D models to characterize such 3D phenomenon. Nonetheless, by eliminating excessive model simplifications, 3D microwave imaging provides potentially more valuable information over 2D techniques, and as a result, more accurate dielectric property maps may be obtained. In this paper, we present some advances we have made in three-dimensional image reconstruction, and show the results from a 3D breast phantom experiment using our clinical microwave imaging system at Dartmouth Hitchcock Medical Center (DHMC), NH.

  17. Three-dimensional computer visualization of forensic pathology data.

    PubMed

    March, Jack; Schofield, Damian; Evison, Martin; Woodford, Noel

    2004-03-01

    Despite a decade of use in US courtrooms, it is only recently that forensic computer animations have become an increasingly important form of communication in legal spheres within the United Kingdom. Aims Research at the University of Nottingham has been influential in the critical investigation of forensic computer graphics reconstruction methodologies and techniques and in raising the profile of this novel form of data visualization within the United Kingdom. The case study presented demonstrates research undertaken by Aims Research and the Department of Forensic Pathology at the University of Sheffield, which aims to apply, evaluate, and develop novel 3-dimensional computer graphics (CG) visualization and virtual reality (VR) techniques in the presentation and investigation of forensic information concerning the human body. The inclusion of such visualizations within other CG or VR environments may ultimately provide the potential for alternative exploratory directions, processes, and results within forensic pathology investigations.

  18. Computer-assisted three-dimensional reconstruction and simulations of vestibular macular neural connectivities

    NASA Technical Reports Server (NTRS)

    Ross, Muriel D.; Chimento, Thomas; Doshay, David; Cheng, Rei

    1992-01-01

    Results of computer-assisted research concerned with the three-dimensional reconstruction and simulations of vestibular macular neural connectivities are summarized. The discussion focuses on terminal/receptive fields, the question of synapses across the striola, endoplasmic reticulum and its potential role in macular information processing, and the inner epithelial plexus. Also included are preliminary results of computer simulations of nerve fiber collateral functioning, an essential step toward the three-dimensional simulation of a functioning macular neural network.

  19. Single-Frame Cinema. Three Dimensional Computer-Generated Imaging.

    ERIC Educational Resources Information Center

    Cheetham, Edward Joseph, II

    This master's thesis provides a description of the proposed art form called single-frame cinema, which is a category of computer imagery that takes the temporal polarities of photography and cinema and unites them into a single visual vignette of time. Following introductory comments, individual chapters discuss (1) the essential physical…

  20. Color in Three-Dimensional Shaded Computer Graphics and Animation.

    ERIC Educational Resources Information Center

    Collery, Michael T.

    Directed primarily toward the person familiar with computer technology rather than the traditional art educator, this master's thesis addresses new approaches to color theory and its impact on electronic art media. Technical considerations related to color coming from electronic sources, i.e., radiant light, and differences between radiant and…

  1. Computation of three-dimensional flows using two stream functions

    NASA Technical Reports Server (NTRS)

    Greywall, Mahesh S.

    1991-01-01

    An approach to compute 3-D flows using two stream functions is presented. The method generates a boundary fitted grid as part of its solution. Commonly used two steps for computing the flow fields are combined into a single step in the present approach: (1) boundary fitted grid generation; and (2) solution of Navier-Stokes equations on the generated grid. The presented method can be used to directly compute 3-D viscous flows, or the potential flow approximation of this method can be used to generate grids for other algorithms to compute 3-D viscous flows. The independent variables used are chi, a spatial coordinate, and xi and eta, values of stream functions along two sets of suitably chosen intersecting stream surfaces. The dependent variables used are the streamwise velocity, and two functions that describe the stream surfaces. Since for a 3-D flow there is no unique way to define two sets of intersecting stream surfaces to cover the given flow, different types of two sets of intersecting stream surfaces are considered. First, the metric of the (chi, xi, eta) curvilinear coordinate system associated with each type is presented. Next, equations for the steady state transport of mass, momentum, and energy are presented in terms of the metric of the (chi, xi, eta) coordinate system. Also included are the inviscid and the parabolized approximations to the general transport equations.

  2. Numerical procedures for three-dimensional computational surface thermochemistry

    NASA Technical Reports Server (NTRS)

    Milos, Frank S.; Rasky, Daniel J.

    1992-01-01

    Models and equations for surface thermochemistry and near-surface thermophysics of aerodynamically-heated thermal protection materials are reviewed, with particular emphasis on computational boundary conditions for surface mass and energy transfer. The surface energy and mass balances, coupled with an appropriate ablation or surface catalysis model, provide complete thermochemical boundary conditions for a true multidisciplinary solution of the fully coupled fluid-dynamics/solid mechanics problem. Practical approximate solutions can be obtained by using a detailed model with full thermophysics for either the solid or fluid phase amd a semianalytic method for the other half of the problem. A significant increase in the state-of-the-art in aerothermal computational fluid dynamics is possible by uniting CFD methodology with surface thermochemistry boundary conditions and the heat-balance-integral method.

  3. Computational adaptive optics for live three-dimensional biological imaging

    PubMed Central

    Kam, Z.; Hanser, B.; Gustafsson, M. G. L.; Agard, D. A.; Sedat, J. W.

    2001-01-01

    Light microscopy of thick biological samples, such as tissues, is often limited by aberrations caused by refractive index variations within the sample itself. This problem is particularly severe for live imaging, a field of great current excitement due to the development of inherently fluorescent proteins. We describe a method of removing such aberrations computationally by mapping the refractive index of the sample using differential interference contrast microscopy, modeling the aberrations by ray tracing through this index map, and using space-variant deconvolution to remove aberrations. This approach will open possibilities to study weakly labeled molecules in difficult-to-image live specimens. PMID:11274396

  4. Computational Model of Three Dimensional Elastic Wing Driven by Muscles

    NASA Astrophysics Data System (ADS)

    Wang, Z. Jane; Cowen, Nathaniel; Peskin, Charles S.; Childress, Stephen W.

    2003-11-01

    The flapping wing motion observed in nature results from couplings of muscles, flexible wing structures, and unsteady flows. Previously we have studied the unsteady flows and forces of a rigid two dimensional wing undergoing prescribed motion similar to kinematics observed in insects, as a means of understanding basic unsteady aerodynamic mechanisms. In this talk, we describe our recent progress in constructing a more realistic model insect, which consists of a pair of elastic wings immersed in fluids, and is driven by periodically contracting 'muscles'. A natural computational framework for such a system is the immersed boundary method, which is used here. We present simulations of flapping flight at Reynolds number 10^2, in the same range as that of fruitflies and butterflies.

  5. Three-dimensional radiative transfer on a massively parallel computer

    NASA Technical Reports Server (NTRS)

    Vath, H. M.

    1994-01-01

    We perform 3D radiative transfer calculations in non-local thermodynamic equilibrium (NLTE) in the simple two-level atom approximation on the Mas-Par MP-1, which contains 8192 processors and is a single instruction multiple data (SIMD) machine, an example of the new generation of massively parallel computers. On such a machine, all processors execute the same command at a given time, but on different data. To make radiative transfer calculations efficient, we must re-consider the numerical methods and storage of data. To solve the transfer equation, we adopt the short characteristic method and examine different acceleration methods to obtain the source function. We use the ALI method and test local and non-local operators. Furthermore, we compare the Ng and the orthomin methods of acceleration. We also investigate the use of multi-grid methods to get fast solutions for the NLTE case. In order to test these numerical methods, we apply them to two problems with and without periodic boundary conditions.

  6. Massively parallel computation of three-dimensional scramjet combustor

    NASA Astrophysics Data System (ADS)

    Zheng, Z. H.; Le, J. L.

    Recent progress of computational study of scramjet combustor has been described in Refs 1-3. However, detailed flow properties, especially the lateral properties and the sidewall effects are not considered. In this paper, a parallel simulation of an experimental dual-mode scramjet combustor configuration is presented, considering the jet-to-jet symmetry and the full-duct modeling. Turbulence is modeled with the k-ɛ two-equation turbulence model and a 7-specie, 8-equation kinetics model is used to model hydrogen/air combustion. The conservation form of the Navier-Stokes equations with finite-rate chemistry reactions is solved using a diagonal implicit finite-volume method. For the two cases, the three-dimension flow-fields with equivalence ratio Φ=0.0 and 0.35 have been respectively simulated on the COW and MPP. Wall pressure comparisons between CFD and experiments (CARDC and NAL) show fair agreement for the jet-to-jet case. For the full-duct modeling, more detailed flow properties are obtained. The fuelpenetrating heights of the injectors are different because of the effects of the sidewall boundary layer and the shock wave in the combustor. According to numerical results, if adjusting the locations of the injectors, the combustion efficiency could be improved.

  7. Three Dimensional Computer Graphics Federates for the 2012 Smackdown Simulation

    NASA Technical Reports Server (NTRS)

    Fordyce, Crystal; Govindaiah, Swetha; Muratet, Sean; O'Neil, Daniel A.; Schricker, Bradley C.

    2012-01-01

    The Simulation Interoperability Standards Organization (SISO) Smackdown is a two-year old annual event held at the 2012 Spring Simulation Interoperability Workshop (SIW). A primary objective of the Smackdown event is to provide college students with hands-on experience in developing distributed simulations using High Level Architecture (HLA). Participating for the second time, the University of Alabama in Huntsville (UAHuntsville) deployed four federates, two federates simulated a communications server and a lunar communications satellite with a radio. The other two federates generated 3D computer graphics displays for the communication satellite constellation and for the surface based lunar resupply mission. Using the Light-Weight Java Graphics Library, the satellite display federate presented a lunar-texture mapped sphere of the moon and four Telemetry Data Relay Satellites (TDRS), which received object attributes from the lunar communications satellite federate to drive their motion. The surface mission display federate was an enhanced version of the federate developed by ForwardSim, Inc. for the 2011 Smackdown simulation. Enhancements included a dead-reckoning algorithm and a visual indication of which communication satellite was in line of sight of Hadley Rille. This paper concentrates on these two federates by describing the functions, algorithms, HLA object attributes received from other federates, development experiences and recommendations for future, participating Smackdown teams.

  8. Theoretical Basis for CTABS80: A Computer Program for Three-Dimensional Analysis of Building Systems.

    DTIC Science & Technology

    1981-09-01

    other enhanced versions such as XTABS and TABS77. The computer program ETABS (15) was released in 1975. The program allows three-dimensional frame...34A Program for Three-Dimensional Static and Dynamic Analysis of Multi- story Buildings," Structural Mechanics Software Series, Vol. II, University...Conference of Building Officials "Uniform Building Code," Whittier, California, 1979. 15. Wilson, E.L., Hollings, J.P., Dovey, H.H. " ETABS , Three

  9. Real-time application of advanced three-dimensional graphic techniques for research aircraft simulation

    NASA Technical Reports Server (NTRS)

    Davis, Steven B.

    1990-01-01

    Visual aids are valuable assets to engineers for design, demonstration, and evaluation. Discussed here are a variety of advanced three-dimensional graphic techniques used to enhance the displays of test aircraft dynamics. The new software's capabilities are examined and possible future uses are considered.

  10. Generation of three-dimensional unstructured grids by the advancing-front method

    NASA Technical Reports Server (NTRS)

    Lohner, Rainald; Parikh, Paresh

    1988-01-01

    The generation of three-dimensional unstructured grids using the advancing-front technique is described. While this generation technique has been shown to be effective for the generation of unstructured grids in two dimensions, its extension to three-dimensional regions required the development of surface definition software and sophisticated data structures to avoid excessive CPU-time overheads for the search operations involved. After obtaining an initial triangulation of the surfaces, tetrahedrons are generated by successively deleting faces from the generation front. Details of the mesh generation algorithm are given, together with examples and timings.

  11. Three-dimensional position changes of the midface following Le Fort III advancement in syndromic craniosynostosis.

    PubMed

    Bouw, Frederik P; Nout, Erik; van Bezooijen, Jine S; Koudstaal, Maarten J; Veenland, Jifke F; Wolvius, Eppo B

    2015-07-01

    Little is known about the positional change of the Le Fort III segment following advancement. To study this, pre- and postoperative computed tomography scans of 18 craniosynosthosis patients were analyzed. The Le Fort III segment movement was measured by creating a reference coordinate system and by superpositioning the postoperative over the preoperative scan. On both the pre- and postoperative scans, four anatomical landmarks were marked: the most anterior point of the left and right foramen infraorbitale, the nasion, and the anterior nasal spine. A significant anterior movement of the four reference points was observed. No significant transversal differences were found. A significant difference between the anterior movement of the nasion and anterior nasal spine was found. In vertical dimension, there was a significant cranial movement of nasion in the study group. In addition, from all patients standardized lateral X-rays were viewed to determine the location and direction of force application that were linked to the outcomes of the three-dimensional movement of the nasion and anterior nasal spine (ANS) and the surgical technique. Conclusively, a significant advancement of the midface can be achieved with Le Fort III distraction osteogenesis in this specific patient group. Counterclockwise movement seemed to be the most dominant movement despite different modes of anchorage.

  12. Computer program for assessing the theoretical performance of a three dimensional inlet

    NASA Technical Reports Server (NTRS)

    Agnone, A. M.; Kung, F.

    1972-01-01

    A computer program for determining the theoretical performance of a three dimensional inlet is presented. An analysis for determining the capture area, ram force, spillage force, and surface pressure force is presented, along with the necessary computer program. A sample calculation is also included.

  13. THREED: A computer program for three dimensional transformation of coordinates. [in lunar photo triangulation mapping

    NASA Technical Reports Server (NTRS)

    Wong, K. W.

    1974-01-01

    Program THREED was developed for the purpose of a research study on the treatment of control data in lunar phototriangulation. THREED is the code name of a computer program for performing absolute orientation by the method of three-dimensional projective transformation. It has the capability of performing complete error analysis on the computed transformation parameters as well as the transformed coordinates.

  14. Comparison of computational results of a few representative three-dimensional transonic potential flow analysis programs

    NASA Technical Reports Server (NTRS)

    Tanaka, K.; Hirose, H.

    1986-01-01

    The development of transonic aerodynamic computation methods and specific examples, as well as examples of three-dimensional transonic computation in design, are discussed. The case of the transonic transport and the case of the small transport are analyzed. Requirements for programs of the future are itemized.

  15. A computer program for fitting smooth surfaces to an aircraft configuration and other three dimensional geometries

    NASA Technical Reports Server (NTRS)

    Craidon, C. B.

    1975-01-01

    A computer program that uses a three-dimensional geometric technique for fitting a smooth surface to the component parts of an aircraft configuration is presented. The resulting surface equations are useful in performing various kinds of calculations in which a three-dimensional mathematical description is necessary. Programs options may be used to compute information for three-view and orthographic projections of the configuration as well as cross-section plots at any orientation through the configuration. The aircraft geometry input section of the program may be easily replaced with a surface point description in a different form so that the program could be of use for any three-dimensional surface equations.

  16. Computer program to calculate three-dimensional boundary layer flows over wings with wall mass transfer

    NASA Technical Reports Server (NTRS)

    Mclean, J. D.; Randall, J. L.

    1979-01-01

    A system of computer programs for calculating three dimensional transonic flow over wings, including details of the three dimensional viscous boundary layer flow, was developed. The flow is calculated in two overlapping regions: an outer potential flow region, and a boundary layer region in which the first order, three dimensional boundary layer equations are numerically solved. A consistent matching of the two solutions is achieved iteratively, thus taking into account viscous-inviscid interaction. For the inviscid outer flow calculations, the Jameson-Caughey transonic wing program FLO 27 is used, and the boundary layer calculations are performed by a finite difference boundary layer prediction program. Interface programs provide communication between the two basic flow analysis programs. Computed results are presented for the NASA F8 research wing, both with and without distributed surface suction.

  17. Computational hemodynamics of an implanted coronary stent based on three-dimensional cine angiography reconstruction.

    PubMed

    Chen, Mounter C Y; Lu, Po-Chien; Chen, James S Y; Hwang, Ned H C

    2005-01-01

    Coronary stents are supportive wire meshes that keep narrow coronary arteries patent, reducing the risk of restenosis. Despite the common use of coronary stents, approximately 20-35% of them fail due to restenosis. Flow phenomena adjacent to the stent may contribute to restenosis. Three-dimensional computational fluid dynamics (CFD) and reconstruction based on biplane cine angiography were used to assess coronary geometry and volumetric blood flows. A patient-specific left anterior descending (LAD) artery was reconstructed from single-plane x-ray imaging. With corresponding electrocardiographic signals, images from the same time phase were selected from the angiograms for dynamic three-dimensional reconstruction. The resultant three-dimensional LAD artery at end-diastole was adopted for detailed analysis. Both the geometries and flow fields, based on a computational model from CAE software (ANSYS and CATIA) and full three-dimensional Navier-Stroke equations in the CFD-ACE+ software, respectively, changed dramatically after stent placement. Flow fields showed a complex three-dimensional spiral motion due to arterial tortuosity. The corresponding wall shear stresses, pressure gradient, and flow field all varied significantly after stent placement. Combined angiography and CFD techniques allow more detailed investigation of flow patterns in various segments. The implanted stent(s) may be quantitatively studied from the proposed hemodynamic modeling approach.

  18. GEO3D - Three-Dimensional Computer Model of a Ground Source Heat Pump System

    SciTech Connect

    James Menart

    2013-06-07

    This file is the setup file for the computer program GEO3D. GEO3D is a computer program written by Jim Menart to simulate vertical wells in conjunction with a heat pump for ground source heat pump (GSHP) systems. This is a very detailed three-dimensional computer model. This program produces detailed heat transfer and temperature field information for a vertical GSHP system.

  19. An Exploration of Three-Dimensional Integrated Assessment for Computational Thinking

    ERIC Educational Resources Information Center

    Zhong, Baichang; Wang, Qiyun; Chen, Jie; Li, Yi

    2016-01-01

    Computational thinking (CT) is a fundamental skill for students, and assessment is a critical factor in education. However, there is a lack of effective approaches to CT assessment. Therefore, we designed the Three-Dimensional Integrated Assessment (TDIA) framework in this article. The TDIA has two aims: one was to integrate three dimensions…

  20. Three-Dimensional Ignition and Flame Propagation Above Liquid Fuel Pools: Computational Analysis

    NASA Technical Reports Server (NTRS)

    Cai, Jinsheng; Sirignano, William A.

    2001-01-01

    A three-dimensional unsteady reactive Navier-Stokes code is developed to study the ignition and flame spread above liquid fuels initially below the flashpoint temperature. Opposed air flow to the flame spread due to forced and/or natural convection is considered. Pools of finite width and length are studied in air channels of prescribed height and width. Three-dimensional effects of the flame front near the edge of the pool are captured in the computation. The formation of a recirculation zone in the gas phase similar to that found in two-dimensional calculations is also present in the three-dimensional calculations. Both uniform spread and pulsating spread modes are found in the calculated results.

  1. Computational strategies for three-dimensional flow simulations on distributed computer systems

    NASA Technical Reports Server (NTRS)

    Sankar, Lakshmi N.; Weed, Richard A.

    1995-01-01

    This research effort is directed towards an examination of issues involved in porting large computational fluid dynamics codes in use within the industry to a distributed computing environment. This effort addresses strategies for implementing the distributed computing in a device independent fashion and load balancing. A flow solver called TEAM presently in use at Lockheed Aeronautical Systems Company was acquired to start this effort. The following tasks were completed: (1) The TEAM code was ported to a number of distributed computing platforms including a cluster of HP workstations located in the School of Aerospace Engineering at Georgia Tech; a cluster of DEC Alpha Workstations in the Graphics visualization lab located at Georgia Tech; a cluster of SGI workstations located at NASA Ames Research Center; and an IBM SP-2 system located at NASA ARC. (2) A number of communication strategies were implemented. Specifically, the manager-worker strategy and the worker-worker strategy were tested. (3) A variety of load balancing strategies were investigated. Specifically, the static load balancing, task queue balancing and the Crutchfield algorithm were coded and evaluated. (4) The classical explicit Runge-Kutta scheme in the TEAM solver was replaced with an LU implicit scheme. And (5) the implicit TEAM-PVM solver was extensively validated through studies of unsteady transonic flow over an F-5 wing, undergoing combined bending and torsional motion. These investigations are documented in extensive detail in the dissertation, 'Computational Strategies for Three-Dimensional Flow Simulations on Distributed Computing Systems', enclosed as an appendix.

  2. Computational strategies for three-dimensional flow simulations on distributed computer systems

    NASA Astrophysics Data System (ADS)

    Sankar, Lakshmi N.; Weed, Richard A.

    1995-08-01

    This research effort is directed towards an examination of issues involved in porting large computational fluid dynamics codes in use within the industry to a distributed computing environment. This effort addresses strategies for implementing the distributed computing in a device independent fashion and load balancing. A flow solver called TEAM presently in use at Lockheed Aeronautical Systems Company was acquired to start this effort. The following tasks were completed: (1) The TEAM code was ported to a number of distributed computing platforms including a cluster of HP workstations located in the School of Aerospace Engineering at Georgia Tech; a cluster of DEC Alpha Workstations in the Graphics visualization lab located at Georgia Tech; a cluster of SGI workstations located at NASA Ames Research Center; and an IBM SP-2 system located at NASA ARC. (2) A number of communication strategies were implemented. Specifically, the manager-worker strategy and the worker-worker strategy were tested. (3) A variety of load balancing strategies were investigated. Specifically, the static load balancing, task queue balancing and the Crutchfield algorithm were coded and evaluated. (4) The classical explicit Runge-Kutta scheme in the TEAM solver was replaced with an LU implicit scheme. And (5) the implicit TEAM-PVM solver was extensively validated through studies of unsteady transonic flow over an F-5 wing, undergoing combined bending and torsional motion. These investigations are documented in extensive detail in the dissertation, 'Computational Strategies for Three-Dimensional Flow Simulations on Distributed Computing Systems', enclosed as an appendix.

  3. Insights on slab-driven mantle flow from advances in three-dimensional modelling

    NASA Astrophysics Data System (ADS)

    Jadamec, Margarete A.

    2016-10-01

    The wealth of seismic observations collected over the past 20 years has raised intriguing questions about the three-dimensional (3D) nature of the mantle flow field close to subduction zones and provided a valuable constraint for how the plate geometry may influence mantle flow proximal to the slab. In geodynamics, there has been a new direction of subduction zone modelling that has explored the 3D nature of slab-driven mantle flow, motivated in part by the observations from shear wave splitting, but also by the observed variations in slab geometries worldwide. Advances in high-performance computing are now allowing for an unprecedented level of detail to be incorporated into numerical models of subduction. This paper summarizes recent advances from 3D geodynamic models that reveal the complex nature of slab-driven mantle flow, including trench parallel flow, toroidal flow around slab edges, mantle upwelling at lateral slab edges, and small scale convection within the mantle wedge. This implies slab-driven mantle deformation zones occur in the asthenosphere proximal to the slab, wherein the mantle may commonly flow in a different direction and rate than the surface plates, implying laterally variable plate-mantle coupling. The 3D slab-driven mantle flow can explain, in part, the lateral transport of geochemical signatures in subduction zones. In addition, high-resolution geographically referenced models can inform the interpretation of slab structure, where seismic data are lacking. The incorporation of complex plate boundaries into high-resolution, 3D numerical models opens the door to a new avenue of research in model construction, data assimilation, and modelling workflows, and gives 3D immersive visualization a new role in scientific discovery.

  4. Three-dimensional nasal changes following maxillary advancement in cleft patients.

    PubMed

    Stewart, A; McCance, A M; James, D R; Moss, J P

    1996-06-01

    Three-dimensional laser surface scanning of the face was performed before and after Le Fort I maxillary advancement in 24 patients with replaced clefts of the lip and palate. The surgery resulted in advancement of the upper lip and para-alar tissues and an increase in the relative prominence of the nose within the face. These changes were produced at the expense of an increase in nasal width and a reduction in nasal tip protrusion. The changes in nasal morphology showed significant variation among patients.

  5. Three Dimensional Remote Sensing of Vegetation in Human Landscapes Using Computer Vision Technologies

    NASA Astrophysics Data System (ADS)

    Dandois, J.; Ellis, E. C.

    2009-12-01

    Urban and other populated and used landscapes today cover a greater extent globally than do wild ecosystems. Methods for accurate ecological measurements on their vegetation and other ecological properties are therefore essential for ecology and earth science. Yet human landscapes are characterized by complex mosaics of vegetation and built structures that are heterogeneous at very fine spatial scales, therefore defying ecological measurements by conventional two dimensional remote sensing techniques, even when these are applied at fine spatial scales. To better measure and understand human-environment interactions within densely populated landscapes, high-spatial resolution three dimensional (3D) remote sensing techniques are needed. Current methods of remote sensing from aerial and satellite platforms are able to resolve land cover and three-dimensional structure using a combination of passive and active sensor technologies (e.g., optical imagers and LIDAR sensors). Despite such advances, there remain substantial gaps in knowledge about the distribution and biological characteristics of vegetation across all regions of earth, especially in densely populated environments. Here we present new methods for very fine scale 3D remote sensing of vegetation structure using computer vision techniques applied to standard digital photographs taken from consumer grade digital cameras mounted on low-altitude aerial platforms. Computer vision algorithms are used to produce 3D geometry from overlapping images, generating datasets very similar to LIDAR point clouds, and useful for measuring vegetation structure characteristics like canopy structure and tree height. These are then used to estimate vegetation biophysical characteristics like canopy density and biomass. Preliminary results demonstrate that this approach offers great promise as a tool for obtaining ecological measurements such as canopy height and vegetation form at the scale of individual trees in a low-cost and

  6. Quantifying nerve architecture in murine and human airways using three-dimensional computational mapping.

    PubMed

    Scott, Gregory D; Fryer, Allison D; Jacoby, David B

    2013-01-01

    The quantitative histological analysis of airway innervation using tissue sections is challenging because of the sparse and patchy distribution of nerves. Here we demonstrate a method using a computational approach to measure airway nerve architecture that will allow for more complete nerve quantification and the measurement of structural peripheral neuroplasticity in lung development and disease. We demonstrate how our computer analysis outperforms manual scoring in quantifying three-dimensional nerve branchpoints and lengths. In murine lungs, we detected airway epithelial nerves that have not been previously identified because of their patchy distribution, and we quantified their three-dimensional morphology using our computer mapping approach. Furthermore, we show the utility of this approach in bronchoscopic forceps biopsies of human airways, as well as the esophagus, colon, and skin.

  7. Computational Simulations of a Three-Dimensional High-Lift Wing

    NASA Technical Reports Server (NTRS)

    Khorrami, M. R.; Berkman, M. E.; Li, F.; Singer, B. A.

    2002-01-01

    Highly resolved computational simulations of a three-dimensional high-lift wing are presented. The steady Reynolds Averaged Navier-Stokes computations are geared towards understanding the flow intricacies associated with inboard and outboard flap side edges. Both moderate and high flap deflections are simulated. Computed surface pressure fields accurately capture the footprint of vortices at flap side edges and are in excellent agreement with pressure sensitive paint measurements. The computations reveal that the outboard vortex possesses higher rotational velocities and lower core pressure than the inboard vortex and therefore is susceptible to severe vortex breakdown.

  8. Computational hydrodynamics of animal swimming: boundary element method and three-dimensional vortex wake structure.

    PubMed

    Cheng, J Y; Chahine, G L

    2001-12-01

    The slender body theory, lifting surface theories, and more recently panel methods and Navier-Stokes solvers have been used to study the hydrodynamics of fish swimming. This paper presents progress on swimming hydrodynamics using a boundary integral equation method (or boundary element method) based on potential flow model. The unsteady three-dimensional BEM code 3DynaFS that we developed and used is able to model realistic body geometries, arbitrary movements, and resulting wake evolution. Pressure distribution over the body surface, vorticity in the wake, and the velocity field around the body can be computed. The structure and dynamic behavior of the vortex wakes generated by the swimming body are responsible for the underlying fluid dynamic mechanisms to realize the high-efficiency propulsion and high-agility maneuvering. Three-dimensional vortex wake structures are not well known, although two-dimensional structures termed 'reverse Karman Vortex Street' have been observed and studied. In this paper, simulations about a swimming saithe (Pollachius virens) using our BEM code have demonstrated that undulatory swimming reduces three-dimensional effects due to substantially weakened tail tip vortex, resulting in a reverse Karman Vortex Street as the major flow pattern in the three-dimensional wake of an undulating swimming fish.

  9. Three-dimensional assessment of mandibular advancement 1 year after surgery

    PubMed Central

    de Assis Ribeiro Carvalho, Felipe; Cevidanes, Lucia Helena Soares; Motta, Alexandre Trindade Simões da; de Oliveira Almeida, Marco Antonio; Phillips, Ceib

    2010-01-01

    Introduction This prospective observational study evaluated changes in the 3-dimensional position and remodeling of the mandibular rami, condyles, and chin at splint removal and 1 year after mandibular advancement surgery. Methods Presurgery, splint removal (4–6 weeks postsurgery), and 1-year postsurgery cone-beam computed tomography scans of 27 subjects were used. Superimposition on the cranial base was used to assess positional or remodeling changes in the anatomic regions of interest. Surface distance displacements were visually displayed and quantified by 3-dimensional color maps. A 1-sample t test was used to assess the average postsurgical changes of each region of interest. The level of significance was set at 0.05. Results After antero-inferior chin displacement with surgery (mean, 6.81 ± 3.2 mm at splint removal), the average 1-year post-surgery displacement was not statistically significant (P = 0.44). Postsurgical adaptations greater than 2 mm were observed in 48% of the patients: 16% with an additional anterior-inferior displacement of the chin of 2 to 4 mm, and 4% with ≥4 mm; 20% had postero-superior movement of 2 to 4 mm, and 8% had postero-superior movement of ≥4 mm. The condyles tended to move, on average, ≤2 mm supero-posteriorly with surgery, and this small positional displacement was maintained 1 year postsurgery (right condyle, P = 0.58; left, P = 0.88). The rami exhibited outward (lateral) movements with surgery, with greater displacement of the inferior part of the rami (≥2 mm in 65% of the subjects). This torque of the ramus with surgery was stable 1 year postsurgery. Conclusions Three-dimensional assessment of skeletal changes with mandibular advancement surgery shows that nearly half of the patients have >2 mm change in chin position from splint removal to the 1-year follow-up, with approximately equal chances of anterior and posterior movement. Torque of the rami usually occurs with mandibular advancement surgery. PMID:20381760

  10. A computer code for three-dimensional incompressible flows using nonorthogonal body-fitted coordinate systems

    NASA Technical Reports Server (NTRS)

    Chen, Y. S.

    1986-01-01

    In this report, a numerical method for solving the equations of motion of three-dimensional incompressible flows in nonorthogonal body-fitted coordinate (BFC) systems has been developed. The equations of motion are transformed to a generalized curvilinear coordinate system from which the transformed equations are discretized using finite difference approximations in the transformed domain. The hybrid scheme is used to approximate the convection terms in the governing equations. Solutions of the finite difference equations are obtained iteratively by using a pressure-velocity correction algorithm (SIMPLE-C). Numerical examples of two- and three-dimensional, laminar and turbulent flow problems are employed to evaluate the accuracy and efficiency of the present computer code. The user's guide and computer program listing of the present code are also included.

  11. Computational modeling of three-dimensional electrodiffusion in biological systems: application to the node of Ranvier.

    PubMed

    Lopreore, Courtney L; Bartol, Thomas M; Coggan, Jay S; Keller, Daniel X; Sosinsky, Gina E; Ellisman, Mark H; Sejnowski, Terrence J

    2008-09-15

    A computational model is presented for the simulation of three-dimensional electrodiffusion of ions. Finite volume techniques were used to solve the Poisson-Nernst-Planck equation, and a dual Delaunay-Voronoi mesh was constructed to evaluate fluxes of ions, as well as resulting electric potentials. The algorithm has been validated and applied to a generalized node of Ranvier, where numerical results for computed action potentials agree well with cable model predictions for large clusters of voltage-gated ion channels. At smaller channel clusters, however, the three-dimensional electrodiffusion predictions diverge from the cable model predictions and show a broadening of the action potential, indicating a significant effect due to each channel's own local electric field. The node of Ranvier complex is an elaborate organization of membrane-bound aqueous compartments, and the model presented here represents what we believe is a significant first step in simulating electrophysiological events with combined realistic structural and physiological data.

  12. Three-dimensional computed tomography from interferometric measurements within a narrow cone of views

    NASA Technical Reports Server (NTRS)

    Decker, Arthur J.; Izen, Steven H.

    1991-01-01

    A theory to determine the properties of a fluid from measurements of its projections was developed and tested. Viewing cones as small as 10 degrees were evaluated, with the only assumption being that the property was space limited. The results of applying the theory to numerical and actual interferograms of a spherical discontinuity of refractive index are presented. The theory was developed to test the practicality and limits of using three-dimensional computer tomography in internal fluid dynamics.

  13. User’s Guide: Computer Program for Three-Dimensional Analysis of Building Systems (CTABS80).

    DTIC Science & Technology

    1981-08-01

    version of TABS and is intended to supercede other enhanced versions such as XTABS and TABS77. The computer program ETABS (15) was released in 1975...Static and Dynamic Analysis of Multi- story Buildings," Structural Mechanics Software Series, Vol. II, University Press of Virginia, 1978. 4. Peterson, F.E...Building Code," Whittier, California, 1979. 15. Wilson, E.L., Hollings, J.P., Dovey, H.H. " ETABS , Three Dimensional Analysis of Building Systems

  14. Three-Dimensional Computational Model for Flow in an Over-Expanded Nozzle With Porous Surfaces

    NASA Technical Reports Server (NTRS)

    Abdol-Hamid, K. S.; Elmiligui, Alaa; Hunter, Craig A.; Massey, Steven J.

    2006-01-01

    A three-Dimensional computational model is used to simulate flow in a non-axisymmetric, convergent-divergent nozzle incorporating porous cavities for shock-boundary layer interaction control. The nozzle has an expansion ratio (exit area/throat area) of 1.797 and a design nozzle pressure ratio of 8.78. Flow fields for the baseline nozzle (no porosity) and for the nozzle with porous surfaces of 10% openness are computed for Nozzle Pressure Ratio (NPR) varying from 1.29 to 9.54. The three dimensional computational results indicate that baseline (no porosity) nozzle performance is dominated by unstable, shock-induced, boundary-layer separation at over-expanded conditions. For NPR less than or equal to 1.8, the separation is three dimensional, somewhat unsteady, and confined to a bubble (with partial reattachment over the nozzle flap). For NPR greater than or equal to 2.0, separation is steady and fully detached, and becomes more two dimensional as NPR increased. Numerical simulation of porous configurations indicates that a porous patch is capable of controlling off design separation in the nozzle by either alleviating separation or by encouraging stable separation of the exhaust flow. In the present paper, computational simulation results, wall centerline pressure, mach contours, and thrust efficiency ratio are presented, discussed and compared with experimental data. Results indicate that comparisons are in good agreement with experimental data. The three-dimensional simulation improves the comparisons for over-expanded flow conditions as compared with two-dimensional assumptions.

  15. Computer programs for estimating aircraft takeoff performance in three dimensional space

    NASA Technical Reports Server (NTRS)

    Bowles, J. V.

    1974-01-01

    A set of computer programs has been developed to estimate the takeoff and initial climb-out maneuver of a given aircraft in three-dimensional space. The program is applicable to conventional, vectored lift and power-lift concept aircraft. The aircraft is treated as a point mass flying over a flat earth with no side slip, and the rotational dynamics have been neglected. The required input is described and a sample case presented.

  16. Interactive computer graphic surface modeling of three-dimensional solid domains for boundary element analysis

    NASA Technical Reports Server (NTRS)

    Perucchio, R.; Ingraffea, A. R.

    1984-01-01

    The establishment of the boundary element method (BEM) as a valid tool for solving problems in structural mechanics and in other fields of applied physics is discussed. The development of an integrated interactive computer graphic system for the application of the BEM to three dimensional problems in elastostatics is described. The integration of interactive computer graphic techniques and the BEM takes place at the preprocessing and postprocessing stages of the analysis process, when, respectively, the data base is generated and the results are interpreted. The interactive computer graphic modeling techniques used for generating and discretizing the boundary surfaces of a solid domain are outlined.

  17. Computation of pair distribution functions and three-dimensional densities with a reduced variance principle

    NASA Astrophysics Data System (ADS)

    Borgis, Daniel; Assaraf, Roland; Rotenberg, Benjamin; Vuilleumier, Rodolphe

    2013-12-01

    No fancy statistical objects here, we go back to the computation of one of the most basic and fundamental quantities in the statistical mechanics of fluids, namely the pair distribution functions. Those functions are usually computed in molecular simulations by using histogram techniques. We show here that they can be estimated using a global information on the instantaneous forces acting on the particles, and that this leads to a reduced variance compared to the standard histogram estimators. The technique is extended successfully to the computation of three-dimensional solvent densities around tagged molecular solutes, quantities that are noisy and very long to converge, using histograms.

  18. A combined direct/inverse three-dimensional transonic wing design method for vector computers

    NASA Technical Reports Server (NTRS)

    Weed, R. A.; Carlson, L. A.; Anderson, W. K.

    1984-01-01

    A three-dimensional transonic-wing design algorithm for vector computers is developed, and the results of sample computations are presented graphically. The method incorporates the direct/inverse scheme of Carlson (1975), a Cartesian grid system with boundary conditions applied at a mean plane, and a potential-flow solver based on the conservative form of the full potential equation and using the ZEBRA II vectorizable solution algorithm of South et al. (1980). The accuracy and consistency of the method with regard to direct and inverse analysis and trailing-edge closure are verified in the test computations.

  19. Three-dimensional computer-aided surgical workflow to aid in reconstruction: From diagnosis to surgical treatment.

    PubMed

    Sándor, George K; Bujtár, Péter; Wolf, Jan

    2014-01-01

    The development of three-dimensional computer-aided surgical workflow has simplified the planning of complex reconstruction cases. It can also be helpful in planning distraction osteogenesis cases. This article examines the evolving role of three-dimensional computer-aided surgical workflow in maxillofacial surgery.

  20. Computer Algorithms and Architectures for Three-Dimensional Eddy-Current Nondestructive Evaluation. Volume 1. Executive Summary

    DTIC Science & Technology

    1989-01-20

    LLAA6 .l iI -SA/TR-2/89 A003: FINAL REPORT * COMPUTER ALGORITHMS AND ARCHITECTURES N FOR THREE-DIMENSIONAL EDDY-CURRENT NONDESTRUCTIVE EVALUATION...Ciasuication) COMPUTER ALGORITHMS AND ARCHITECTURES FOR THREE-DIMENSIONAL EDD~j~~JRRN iv ummary Q PERSONAL AUTriOR(S) SBAHASCAE 1 3a. TYPE Of REPORT

  1. Determination of midsagittal plane for evaluation of facial asymmetry using three-dimensional computed tomography

    PubMed Central

    Kim, Tae-Young; Baik, Jee-Seon; Park, Joo-Young; Chae, Hwa-Sung; Choi, Soon-Chul

    2011-01-01

    Purpose The aim of the present study was to investigate the disagreement of cephalometric analysis depending on the reference determination of midsagittal plane on three-dimensional computed tomography. Materials and Methods A total of 102 young women with class III dentofacial deformity were evaluated using three-dimensional computed tomography. The cranial and facial midsagittal planes were defined and the amounts of jaw deviation were calculated. The amounts of jaw deviation were compared with paired t-test (2-tailed) and Bland-Altman plot was drawn. Results The landmark tracing were reproducible (r≥.978). The jaws relative to the cranial midsagittal plane were 10-17 times more significantly deviated than to the facial midsagittal plane (P<.001). Bland-Altman plot demonstrated that the differences between the amounts of jaw deviation from two midsagittal planes were not normally distributed versus the average of the amounts of jaw deviation from two midsagittal planes. Conclusion The cephalometric analyses of facial asymmetry were significantly inconsistent depending on the reference determination of midsagittal plane. The reference for midsagittal plane should be carefully determined in three-dimensional cephalometric analysis of facial asymmetry of patients with class III dentofacial deformity. PMID:21977479

  2. A method for obtaining three-dimensional computation equilibrium of non-neutral plasmas using WARP

    SciTech Connect

    Wurtele, J.; Wurtele, J.; Friedman, A.; Grote, D.P.; Vay, J-L.; Gomberoff, K.

    2006-03-25

    Computer simulation studies of the stability and transport properties of trapped non-neutral plasmas require the numerical realization of a three-dimensional plasma distribution. This paper presents a new numerical method for obtaining, without an explicit model for physical collisions in the code, a low noise three-dimensional computational equilibrium distribution. This requires both the loading of particles into an idealized distribution and the relaxation from that distribution toward an approximate numerical equilibrium. The equilibrium can then be modified through a slow change of system parameters, to generate other equilibria. In the present work we apply this method to a UC Berkeley experiment on electron confinement in magnetic geometries appropriate for the ALPHA anti-hydrogen experiment, using the three-dimensional Particle-In-Cell code WARP. WARP's guiding center mover and its option to switch between different solvers during a simulation are highly valuable because they speed up the simulations; they enable the practical use of the new technique for generating numerical equilibrium states of trapped nonneutral plasmas.

  3. A method for obtaining three-dimensional computational equilibrium of non-neutral plasmas using WARP

    SciTech Connect

    Gomberoff, K. . E-mail: katia@physics.technion.ac.il; Wurtele, J.; Friedman, A.; Grote, D.P.; Vay, J.-L.

    2007-08-10

    Computer simulation studies of the stability and transport properties of trapped non-neutral plasmas require the numerical realization of a three-dimensional plasma distribution. This paper presents a new numerical method for obtaining, without an explicit model for physical collisions in the code, a low noise three-dimensional computational equilibrium distribution. This requires both the loading of particles into an idealized distribution and the relaxation from that distribution toward an approximate numerical equilibrium. The equilibrium can then be modified through a slow change of system parameters, to generate other equilibria. In the present, work we apply this method to a UC Berkeley experiment on electron confinement in magnetic geometries appropriate for the ALPHA anti-hydrogen experiment, using the three-dimensional particle-in-cell code WARP. WARP's guiding center mover and its option to switch between different solvers during a simulation are highly valuable because they speed up the simulations; they enable the practical use of the new technique for generating numerical equilibrium states of trapped non-neutral plasmas.

  4. High performance computing for three-dimensional agent-based molecular models.

    PubMed

    Pérez-Rodríguez, G; Pérez-Pérez, M; Fdez-Riverola, F; Lourenço, A

    2016-07-01

    Agent-based simulations are increasingly popular in exploring and understanding cellular systems, but the natural complexity of these systems and the desire to grasp different modelling levels demand cost-effective simulation strategies and tools. In this context, the present paper introduces novel sequential and distributed approaches for the three-dimensional agent-based simulation of individual molecules in cellular events. These approaches are able to describe the dimensions and position of the molecules with high accuracy and thus, study the critical effect of spatial distribution on cellular events. Moreover, two of the approaches allow multi-thread high performance simulations, distributing the three-dimensional model in a platform independent and computationally efficient way. Evaluation addressed the reproduction of molecular scenarios and different scalability aspects of agent creation and agent interaction. The three approaches simulate common biophysical and biochemical laws faithfully. The distributed approaches show improved performance when dealing with large agent populations while the sequential approach is better suited for small to medium size agent populations. Overall, the main new contribution of the approaches is the ability to simulate three-dimensional agent-based models at the molecular level with reduced implementation effort and moderate-level computational capacity. Since these approaches have a generic design, they have the major potential of being used in any event-driven agent-based tool.

  5. A Computer Program for the Calculation of Three-Dimensional Transonic Nacelle/Inlet Flowfields

    NASA Technical Reports Server (NTRS)

    Vadyak, J.; Atta, E. H.

    1983-01-01

    A highly efficient computer analysis was developed for predicting transonic nacelle/inlet flowfields. This algorithm can compute the three dimensional transonic flowfield about axisymmetric (or asymmetric) nacelle/inlet configurations at zero or nonzero incidence. The flowfield is determined by solving the full-potential equation in conservative form on a body-fitted curvilinear computational mesh. The difference equations are solved using the AF2 approximate factorization scheme. This report presents a discussion of the computational methods used to both generate the body-fitted curvilinear mesh and to obtain the inviscid flow solution. Computed results and correlations with existing methods and experiment are presented. Also presented are discussions on the organization of the grid generation (NGRIDA) computer program and the flow solution (NACELLE) computer program, descriptions of the respective subroutines, definitions of the required input parameters for both algorithms, a brief discussion on interpretation of the output, and sample cases to illustrate application of the analysis.

  6. Three-dimensional visualization of objects in scattering medium by use of computational integral imaging.

    PubMed

    Moon, Inkyu; Javidi, Bahram

    2008-08-18

    In this paper, we propose a method to three-dimensionally visualize objects in a scattering medium using integral imaging. Our approach is based on a particular use of the interference phenomenon between the ballistic photons getting through the scattering medium and the scattered photons being scattered by the medium. For three-dimensional (3D) sensing of the scattered objects, the synthetic aperture integral imaging system under coherent illumination records the scattered elemental images of the objects. Then, the computational geometrical ray propagation algorithm is applied to the scattered elemental images in order to eliminate the interference patterns between scattered and object beams. The original 3D information of the scattered objects is recovered by multiple imaging channels, each with a unique perspective of the object. We present both simulation and experimental results with virtual and real objects to demonstrate the proposed concepts.

  7. Computational analysis of three-dimensional epithelial morphogenesis using vertex models

    PubMed Central

    Du, XinXin; Osterfield, Miriam; Shvartsman, Stanislav Y.

    2014-01-01

    The folding of epithelial sheets, accompanied by cell shape changes and rearrangements, gives rise to three-dimensional structures during development. Recently, some aspects of epithelial morphogenesis have been modeled using vertex models, in which each cell is approximated by a polygon; however, these models have been largely confined to two dimensions. Here, we describe an adaptation of these models in which the classical two-dimensional vertex model is embedded in three dimensions. This modification allows for the construction of complex three-dimensional shapes from simple sheets of cells. We describe algorithmic, computational, and biophysical aspects of our model, with the view that it may be useful for formulating and testing hypotheses regarding the mechanical forces underlying a wide range of morphogenetic processes. PMID:25410646

  8. Numerical computation of three-dimensional blunt body flow fields with an impinging shock

    NASA Technical Reports Server (NTRS)

    Holst, T. L.; Tannehill, J. C.

    1975-01-01

    A time-marching finite-difference method was used to solve the compressible Navier-Stokes equations for the three-dimensional wing-leading-edge shock impingement problem. The bow shock was treated as a discontinuity across which the exact shock jump conditions were applied. All interior shock layer detail such as shear layers, shock waves, jets, and the wall boundary layer were automatically captured in the solution. The impinging shock was introduced by discontinuously changing the freestream conditions across the intersection line at the bow shock. A special storage-saving procedure for sweeping through the finite-difference mesh was developed which reduces the required amount of computer storage by at least a factor of two without sacrificing the execution time. Numerical results are presented for infinite cylinder blunt body cases as well as the three-dimensional shock impingement case. The numerical results are compared with existing experimental and theoretical results.

  9. WIND: Computer program for calculation of three dimensional potential compressible flow about wind turbine rotor blades

    NASA Technical Reports Server (NTRS)

    Dulikravich, D. S.

    1980-01-01

    A computer program is presented which numerically solves an exact, full potential equation (FPE) for three dimensional, steady, inviscid flow through an isolated wind turbine rotor. The program automatically generates a three dimensional, boundary conforming grid and iteratively solves the FPE while fully accounting for both the rotating cascade and Coriolis effects. The numerical techniques incorporated involve rotated, type dependent finite differencing, a finite volume method, artificial viscosity in conservative form, and a successive line overrelaxation combined with the sequential grid refinement procedure to accelerate the iterative convergence rate. Consequently, the WIND program is capable of accurately analyzing incompressible and compressible flows, including those that are locally transonic and terminated by weak shocks. The program can also be used to analyze the flow around isolated aircraft propellers and helicopter rotors in hover as long as the total relative Mach number of the oncoming flow is subsonic.

  10. Evaluation of the three-dimensional parabolic flow computer program SHIP

    NASA Technical Reports Server (NTRS)

    Pan, Y. S.

    1978-01-01

    The three-dimensional parabolic flow program SHIP designed for predicting supersonic combustor flow fields is evaluated to determine its capabilities. The mathematical foundation and numerical procedure are reviewed; simplifications are pointed out and commented upon. The program is then evaluated numerically by applying it to several subsonic and supersonic, turbulent, reacting and nonreacting flow problems. Computational results are compared with available experimental or other analytical data. Good agreements are obtained when the simplifications on which the program is based are justified. Limitations of the program and the needs for improvement and extension are pointed out. The present three dimensional parabolic flow program appears to be potentially useful for the development of supersonic combustors.

  11. Hepatic vessel segmentation from computed tomography using three-dimensional hyper-complex edge detection operator

    NASA Astrophysics Data System (ADS)

    Ma, Yang; Li, Xingmin

    2014-01-01

    This paper proposes a three-dimensional(3D) segmentation algorithm using hyper-complex edge detection operator and applies the new algorithm to three-dimensional hepatic vessel segmentation from computed tomography (CT) volumetric data. A 3D hyper-complex edge detection operator is constructed by combining octonion and gradient operator. We replace every voxel of the volumetric data by one octonion which consist of its gray-level and its 6 neighborhoods' gray-level. Via this the original volumetric data is defined as octonion volumetric data. Similar to the Sobel operator, there are three principal directions (coordinate axes) in 3D hyper-complex edge detection operator, and each element in this operator is a octonion. The operator is circularly convoluted with octonion volumetric data to get the value of matching response. If matched, this voxel is the edge of vessel. Experimental results show that the algorithm can effectively segment small vascular tree branches.

  12. Three-dimensional unsteady flow calculations in an advanced gas generator turbine

    NASA Technical Reports Server (NTRS)

    Rangwalla, Akil A.

    1993-01-01

    This paper deals with the application of a three-dimensional, unsteady Navier-Stokes code for predicting the unsteady flow in a single stage of an advanced gas generator turbine. The numerical method solves the three-dimensional thin-layer Navier-Stokes equations, using a system of overlaid grids, which allow for relative motion between the rotor and stator airfoils. Results in the form of time averaged pressures and pressure amplitudes on the airfoil surfaces will be shown. In addition, instantaneous contours of pressure, Mach number, etc. will be presented in order to provide a greater understanding of the inviscid as well as the viscous aspects of the flowfield. Also, relevant secondary flow features such as cross-plane velocity vectors and total pressure contours will be presented. Prior work in two-dimensions has indicated that for the advanced designs, the unsteady interactions can play a significant role in turbine performance. These interactions affect not only the stage efficiency but can substantially alter the time-averaged features of the flow. This work is a natural extension of the work done in two-dimensions and hopes to address some of the issues raised by the two-dimensional calculations. These calculations are being performed as an integral part of an actual design process and demonstrate the value of unsteady rotor-stator interaction calculations in the design of turbomachines.

  13. Computational And Experimental Studies Of Three-Dimensional Flame Spread Over Liquid Fuel Pools

    NASA Technical Reports Server (NTRS)

    Ross, Howard D. (Technical Monitor); Cai, Jinsheng; Liu, Feng; Sirignano, William A.; Miller, Fletcher J.

    2003-01-01

    Schiller, Ross, and Sirignano (1996) studied ignition and flame spread above liquid fuels initially below the flashpoint temperature by using a two-dimensional computational fluid dynamics code that solves the coupled equations of both the gas and the liquid phases. Pulsating flame spread was attributed to the establishment of a gas-phase recirculation cell that forms just ahead of the flame leading edge because of the opposing effect of buoyancy-driven flow in the gas phase and the thermocapillary-driven flow in the liquid phase. Schiller and Sirignano (1996) extended the same study to include flame spread with forced opposed flow in the gas phase. A transitional flow velocity was found above which an originally uniform spreading flame pulsates. The same type of gas-phase recirculation cell caused by the combination of forced opposed flow, buoyancy-driven flow, and thermocapillary-driven concurrent flow was responsible for the pulsating flame spread. Ross and Miller (1998) and Miller and Ross (1998) performed experimental work that corroborates the computational findings of Schiller, Ross, and Sirignano (1996) and Schiller and Sirignano (1996). Cai, Liu, and Sirignano (2002) developed a more comprehensive three-dimensional model and computer code for the flame spread problem. Many improvements in modeling and numerical algorithms were incorporated in the three-dimensional model. Pools of finite width and length were studied in air channels of prescribed height and width. Significant three-dimensional effects around and along the pool edge were observed. The same three-dimensional code is used to study the detailed effects of pool depth, pool width, opposed air flow velocity, and different levels of air oxygen concentration (Cai, Liu, and Sirignano, 2003). Significant three-dimensional effects showing an unsteady wavy flame front for cases of wide pool width are found for the first time in computation, after being noted previously by experimental observers (Ross

  14. Computation of three-dimensional flow in turbofan mixers and comparison with experimental data

    NASA Technical Reports Server (NTRS)

    Povinelli, L. A.; Anderson, B. H.; Gerstenmaier, W.

    1980-01-01

    A three dimensional, viscous computer code was used to calculate the mixing downstream of a typical turbofan mixer geometry. Experimental data obtained using pressure and temperature rakes at the lobe and nozzle exit stations were used to validate the computer results. The relative importance of turbulence in the mixing phenomenon as compared with the streamwise vorticity set up by the secondary flows was determined. The observations suggest that the generation of streamwise vorticity plays a significant role in determining the temperature distribution at the nozzle exit plane.

  15. Simulations of Failure via Three-Dimensional Cracking in Fuel Cladding for Advanced Nuclear Fuels

    SciTech Connect

    Lu, Hongbing; Bukkapatnam, Satish; Harimkar, Sandip; Singh, Raman; Bardenhagen, Scott

    2014-01-09

    Enhancing performance of fuel cladding and duct alloys is a key means of increasing fuel burnup. This project will address the failure of fuel cladding via three-dimensional cracking models. Researchers will develop a simulation code for the failure of the fuel cladding and validate the code through experiments. The objective is to develop an algorithm to determine the failure of fuel cladding in the form of three-dimensional cracking due to prolonged exposure under varying conditions of pressure, temperature, chemical environment, and irradiation. This project encompasses the following tasks: 1. Simulate 3D crack initiation and growth under instantaneous and/or fatigue loads using a new variant of the material point method (MPM); 2. Simulate debonding of the materials in the crack path using cohesive elements, considering normal and shear traction separation laws; 3. Determine the crack propagation path, considering damage of the materials incorporated in the cohesive elements to allow the energy release rate to be minimized; 4. Simulate the three-dimensional fatigue crack growth as a function of loading histories; 5. Verify the simulation code by comparing results to theoretical and numerical studies available in the literature; 6. Conduct experiments to observe the crack path and surface profile in unused fuel cladding and validate against simulation results; and 7. Expand the adaptive mesh refinement infrastructure parallel processing environment to allow adaptive mesh refinement at the 3D crack fronts and adaptive mesh merging in the wake of cracks. Fuel cladding is made of materials such as stainless steels and ferritic steels with added alloying elements, which increase stability and durability under irradiation. As fuel cladding is subjected to water, chemicals, fission gas, pressure, high temperatures, and irradiation while in service, understanding performance is essential. In the fast fuel used in advanced burner reactors, simulations of the nuclear

  16. Computer aided shot reconstructions by means of individualized animated three-dimensional victim models.

    PubMed

    Subke, Jörg; Haase, Sibylle; Wehner, Heinz Dieter; Wehner, Frank

    2002-02-18

    In cases of lethal firearm injuries with indefinite indications concerning self-versus third-party infliction a computer enhanced reconstruction with the aim of an anatomical feasibility study can provide significant clues concerning the course of the traumatic event. To this end an exact three-dimensional geometrical model of the victim including all relevant anatomical data as well as the careful documentation of the injuries and a three-dimensional model of the characteristic outlines of the weapon true to scale is generated with the help of an animation program (POSER Version 4, Meta Creation, Egisys AG). With this animated digital three-dimensional model of the victim and the weapon a series of simulation sequences is created by variation of the body positions and the grasp of the weapon. Anatomically impossible positions in view of the physical characteristics of the victim and the site and direction of the bullet path are automatically excluded from the reconstruction. An exact match of the simulation sequence and the real injuries is a statement for a possible self-infliction of the gunshot wound.

  17. Mach 10 computational study of a three-dimensional scramjet inlet flow field

    NASA Technical Reports Server (NTRS)

    Holland, Scott D.

    1995-01-01

    The present work documents the computational results for a combined computational and experimental parametric study of the internal aerodynamics of a generic three-dimensional sidewall-compression scramjet inlet configuration at Mach 10. The three-dimensional Navier-Stokes code SCRAMIN was chosen for the computational portion of the study because it uses a well-known and well-proven numerical scheme and has shown favorable comparison with experiment at Mach numbers between 2 and 6. One advantage of CFD was that it provided flow field data for a detailed examination of the internal flow characteristics in addition to the surface properties. The experimental test matrix at mach 10 included three geometric contraction ratios (3, 5, and 9), three Reynolds numbers (0.55 x 10(exp 6) per foot, 1.14 x 10(exp 6) per foot, and 2.15 x 10(exp 6) per foot), and three cowl positions (at the throat and two forward positions). Computational data for two of these configurations (the contraction ratio of 3, Re = 2.15 x 10 (exp 6) per foot, at two cowl positions) are presented along with a detailed analysis of the flow interactions in successive computational planes.

  18. Mach 10 computational study of a three-dimensional scramjet inlet flow field

    NASA Technical Reports Server (NTRS)

    Holland, Scott D.

    1995-01-01

    The present work documents the computational results for a combined computational and experimental parametric study of the internal aerodynamics of a generic three-dimensional sidewall-compression scramjet inlet configuration at Mach 10. The three-dimensional Navier-Stokes code SCRAMIN was chosen for the computational portion of the study because it uses a well-known and well-proven numerical scheme and has shown favorable comparison with experiment at Mach numbers between 2 and 6. One advantage of CFD was that it provided flow field data for a detailed examination of the internal flow characteristics in addition to the surface properties. The experimental test matrix at Mach 10 included three geometric contraction ratios (3, 5, and 9), three Reynolds numbers (0.55 x 10(exp 6) per foot, 1.14 x 10(exp 6) per foot, and 2.15 x 10(exp 6) per foot), and three cowl positions (at the throat and two forward positions). Computational data for two of these configurations (the contraction ratio of 3, Re = 2.15 x 10(exp 6) per foot, at two cowl positions) are presented along with a detailed analysis of the flow interactions in successive computational planes.

  19. Three-Dimensional Integration Technology for Advanced Focal Planes and Integrated Circuits

    SciTech Connect

    Keast, Craig

    2007-02-28

    Over the last five years MIT Lincoln Laboratory (MIT-LL) has developed a three-dimensional (3D) circuit integration technology that exploits the advantages of silicon-on-insulator (SOI) technology to enable wafer-level stacking and micrometer-scale electrical interconnection of fully fabricated circuit wafers. Advanced focal plane arrays have been the first applications to exploit the benefits of this 3D integration technology because the massively parallel information flow present in 2D imaging arrays maps very nicely into a 3D computational structure as information flows from circuit-tier to circuit-tier in the z-direction. To date, the MIT-LL 3D integration technology has been used to fabricate four different focal planes including: a 2-tier 64 x 64 imager with fully parallel per-pixel A/D conversion; a 3-tier 640 x 480 imager consisting of an imaging tier, an A/D conversion tier, and a digital signal processing tier; a 2-tier 1024 x 1024 pixel, 4-side-abutable imaging modules for tiling large mosaic focal planes, and a 3-tier Geiger-mode avalanche photodiode (APD) 3-D LIDAR array, using a 30 volt APD tier, a 3.3 volt CMOS tier, and a 1.5 volt CMOS tier. Recently, the 3D integration technology has been made available to the circuit design research community through DARPA-sponsored Multiproject fabrication runs. The first Multiproject Run (3DL1) completed fabrication in early 2006 and included over 30 different circuit designs from 21 different research groups. 3D circuit concepts explored in this run included stacked memories, field programmable gate arrays (FPGAs), and mixed-signal circuits. The second Multiproject Run (3DM2) is currently in fabrication and includes particle detector readouts designed by Fermilab. This talk will provide a brief overview of MIT-LL's 3D-integration process, discuss some of the focal plane applications where the technology is being applied, and provide a summary of some of the Multiproject Run circuit results.

  20. Advanced three-dimensional scan methods in the nanopositioning and nanomeasuring machine

    NASA Astrophysics Data System (ADS)

    Hausotte, T.; Percle, B.; Jäger, G.

    2009-08-01

    The nanopositioning and nanomeasuring machine developed at the Ilmenau University of Technology was originally designed for surface measurements within a measuring volume of 25 mm × 25 mm × 5 mm. The interferometric length measuring and drive systems make it possible to move the stage with a resolution of 0.1 nm and a positioning uncertainty of less than 10 nm in all three axes. Various measuring tasks are possible depending on the installed probe system. Most of the sensors utilized are one-dimensional surface probes; however, some tasks require measuring sidewalls and other three-dimensional features. A new control system, based on the I++ DME specification, was implemented in the device. The I++ DME scan functions were improved and special scan functions added to allow advanced three-dimensional scan methods, further fulfilling the demands of scanning force microscopy and micro-coordinate measurements. This work gives an overview of these new functions and the application of them for several different measurements.

  1. Use of CYBER 203 and CYBER 205 computers for three-dimensional transonic flow calculations

    NASA Technical Reports Server (NTRS)

    Melson, N. D.; Keller, J. D.

    1983-01-01

    Experiences are discussed for modifying two three-dimensional transonic flow computer programs (FLO 22 and FLO 27) for use on the CDC CYBER 203 computer system. Both programs were originally written for use on serial machines. Several methods were attempted to optimize the execution of the two programs on the vector machine: leaving the program in a scalar form (i.e., serial computation) with compiler software used to optimize and vectorize the program, vectorizing parts of the existing algorithm in the program, and incorporating a vectorizable algorithm (ZEBRA I or ZEBRA II) in the program. Comparison runs of the programs were made on CDC CYBER 175. CYBER 203, and two pipe CDC CYBER 205 computer systems.

  2. Zoomable three-dimensional computer-generated holographic display based on shifted Fresnel diffraction

    NASA Astrophysics Data System (ADS)

    Zhang, Hao; Cao, Liangcai; Zong, Song; Jin, Guofan

    2016-10-01

    We present a technique for generating zoomable three-dimensional (3-D) computer-generated holograms (CGHs) using layer-based shifted Fresnel diffraction. The 3-D scene is sliced into multiple parallel layers according to the depth information. Shifted Fresnel diffraction is implemented in calculating the propagations from different layers to the hologram plane with adjustable sampling rates. The proposed method provides an efficient way for zooming 3-D CGHs without optical zoom module. Optical experiments have been performed, which demonstrate the proposed method can reconstruct quality 3-D images with different scale factors.

  3. Three-dimensional computed tomography image based endovascular treatment for hepatic vein.

    PubMed

    Ninomiya, Mizuki; Ikeda, Tetsuo; Shirabe, Ken; Kayashima, Hiroto; Harimoto, Norifumi; Iguchi, Tomohiro; Sugimachi, Keishi; Yamashita, Yo-Ichi; Ikegami, Toru; Saeki, Hiroshi; Oki, Eiji; Uchiyama, Hideaki; Yoshizumi, Tomoharu; Soejima, Yuji; Kawanaka, Hirofumi; Morita, Masaru; Maehara, Yoshihiko

    2013-11-01

    Along with the expansion of living donor liver transplantation, whereby hepatic venous anastomosis is mandatory, the frequency of hepatic venous stenosis that need interventional treatment is increasing. Due to its anatomical features, there are several pitfalls in the process of endovascular intervention for hepatic vein. Insufficient information of and around the hepatic vein may lead to miss-diagnosis of target lesion. Simulation by using three-dimensional computed tomography images was useful in planning the direction of X-ray projection and, as a consequence, contributed to safe endovascular treatment for hepatic venous stenosis.

  4. Computer reconstruction of the three-dimensional structure of mouse cerebral ventricles.

    PubMed

    Taguchi, Meiko; Chida, Kohsuke

    2003-08-01

    In the brain, the cerebral ventricles are important as the site of cerebrospinal fluid production. The cerebral ventricles consist of the lateral ventricles, the third ventricle and the fourth ventricle, and their stereoscopic structures and the connections between them are not visible from outside of the brain. Observation of the stereoscopic structure of cerebral ventricles is possible by producing a mold preparation of the ventricular system [Systematic Human Anatomy (1984) 589; A Colour Atlas of Human Anatomy (1993) 79; J. Anat. 68 (1934) 480; Brain 75 (1952) 259]. However, this method does not facilitate visualization of the position of the ventricles within the brain or the positional relationships between the cerebral ventricles and other structures. Murine brains are often used in studies of hydrocephalus [Mol. Cell. Biol. 22 (2002) 2769; Brain Res. 891 (2001) 247]. Rolf et al. have reported that a few L1 mutant mice display severe hydrocephalus and suggested that, in such mice, massively enlarged ventricles create deformations of the brain, which secondarily cause stenosis of the aqueducts followed by severe hydrocephalus [Brain Res. 891 (2001) 247]. The three-dimensional structure of murine cerebral ventricles reconstructed on a computer display would be extremely useful not only for stereoscopic observation of the cerebral ventricles in murine brains but also in morphological analysis of murine cerebral ventricles using additional software for three-dimensional measurement. We therefore attempted a three-dimensional computer reconstruction of the cerebral ventricles from serial histological sections of whole mouse brain in order to facilitate research into hydrocephalus using mouse models. In this study, mouse brain is fixed in formalin and then embedded in paraffin after immersion in celloidin. Serial histological sections are produced and digitized, and outlines of the brain surface and cerebral ventricular faces are traced on printouts. Serial

  5. Object-oriented parallel algorithms for computing three-dimensional isopycnal flow

    SciTech Connect

    Concus, Paul; Golub, Gene H.; Sun, Yong

    2000-12-01

    In this paper, we derive an object-oriented parallel algorithm for three-dimensional isopycnal flow simulations. The matrix formulation is central to the algorithm. It enables us to apply an efficient preconditioned conjugate gradient linear solver for the global system of equations, and leads naturally to an object-oriented data structure design and parallel implementation. We discuss as well, in less detail, a similar algorithm based on the reduced system, suitable also for parallel computation. Favorable performances are observed on test problems.

  6. Three-dimensional morphology of heel fat pad: an in vivo computed tomography study

    PubMed Central

    Campanelli, Valentina; Fantini, Massimiliano; Faccioli, Niccolò; Cangemi, Alessio; Pozzo, Antonio; Sbarbati, Andrea

    2011-01-01

    Heel fat pad cushioning efficiency is the result of its structure, shape and thickness. However, while a number of studies have investigated heel fat pad (HFP) anatomy, structural behavior and material properties, no previous study has described its three-dimensional morphology in situ. The assessment of the healthy, unloaded, three-dimensional morphology of heel pad may contribute to deepen the understanding of its role and behavior during locomotion. It is the basis for the assessment of possible HFP morphological modifications due to changes in the amount or distribution of the loads normally sustained by the foot. It may also help in guiding the surgical reconstruction of the pad and in improving footwear design, as well as in developing a correct heel pad geometry for finite element models of the foot. Therefore the purpose of this study was to obtain a complete analysis of HFP three-dimensional morphology in situ. The right foot of nine healthy volunteers was scanned with computed tomography. A methodological approach that maximizes reliability and repeatability of the data was developed by building a device to lock the foot in a neutral position with respect to the scan planes during image acquisition. Scan data were used to reconstruct virtual three-dimensional models for both the calcaneus and HFP. A set of virtual coronal and axial sections were extracted from the three-dimensional model of each HFP and processed to extract a set of one- and two-dimensional morphometrical measurements for a detailed description of heel pad morphology. The tissue exhibited a consistent and sophisticated morphology that may reflect the biomechanics of the foot support. HFP was found to be have a crest on its anterior dorsal surface, flanges on the sides and posteriorly, and a thick portion that reached and covered the posterior surface of the calcaneus and the achilles tendon insertion. Its anterior internal portion was thinner and a lump of fat was consistently present in

  7. Advanced numerical methods for three dimensional two-phase flow calculations

    SciTech Connect

    Toumi, I.; Caruge, D.

    1997-07-01

    This paper is devoted to new numerical methods developed for both one and three dimensional two-phase flow calculations. These methods are finite volume numerical methods and are based on the use of Approximate Riemann Solvers concepts to define convective fluxes versus mean cell quantities. The first part of the paper presents the numerical method for a one dimensional hyperbolic two-fluid model including differential terms as added mass and interface pressure. This numerical solution scheme makes use of the Riemann problem solution to define backward and forward differencing to approximate spatial derivatives. The construction of this approximate Riemann solver uses an extension of Roe`s method that has been successfully used to solve gas dynamic equations. As far as the two-fluid model is hyperbolic, this numerical method seems very efficient for the numerical solution of two-phase flow problems. The scheme was applied both to shock tube problems and to standard tests for two-fluid computer codes. The second part describes the numerical method in the three dimensional case. The authors discuss also some improvements performed to obtain a fully implicit solution method that provides fast running steady state calculations. Such a scheme is not implemented in a thermal-hydraulic computer code devoted to 3-D steady-state and transient computations. Some results obtained for Pressurised Water Reactors concerning upper plenum calculations and a steady state flow in the core with rod bow effect evaluation are presented. In practice these new numerical methods have proved to be stable on non staggered grids and capable of generating accurate non oscillating solutions for two-phase flow calculations.

  8. Computer prediction of three-dimensional potential flow fields in which aircraft propellers operate: Computer program description and users manual

    NASA Technical Reports Server (NTRS)

    Jumper, S. J.

    1979-01-01

    A method was developed for predicting the potential flow velocity field at the plane of a propeller operating under the influence of a wing-fuselage-cowl or nacelle combination. A computer program was written which predicts the three dimensional potential flow field. The contents of the program, its input data, and its output results are described.

  9. An Improved Treatment of External Boundary for Three-Dimensional Flow Computations

    NASA Technical Reports Server (NTRS)

    Tsynkov, Semyon V.; Vatsa, Veer N.

    1997-01-01

    We present an innovative numerical approach for setting highly accurate nonlocal boundary conditions at the external computational boundaries when calculating three-dimensional compressible viscous flows over finite bodies. The approach is based on application of the difference potentials method by V. S. Ryaben'kii and extends our previous technique developed for the two-dimensional case. The new boundary conditions methodology has been successfully combined with the NASA-developed code TLNS3D and used for the analysis of wing-shaped configurations in subsonic and transonic flow regimes. As demonstrated by the computational experiments, the improved external boundary conditions allow one to greatly reduce the size of the computational domain while still maintaining high accuracy of the numerical solution. Moreover, they may provide for a noticeable speedup of convergence of the multigrid iterations.

  10. Fiber pushout test: A three-dimensional finite element computational simulation

    NASA Technical Reports Server (NTRS)

    Mital, Subodh K.; Chamis, Christos C.

    1990-01-01

    A fiber pushthrough process was computationally simulated using three-dimensional finite element method. The interface material is replaced by an anisotropic material with greatly reduced shear modulus in order to simulate the fiber pushthrough process using a linear analysis. Such a procedure is easily implemented and is computationally very effective. It can be used to predict fiber pushthrough load for a composite system at any temperature. The average interface shear strength obtained from pushthrough load can easily be separated into its two components: one that comes from frictional stresses and the other that comes from chemical adhesion between fiber and the matrix and mechanical interlocking that develops due to shrinkage of the composite because of phase change during the processing. Step-by-step procedures are described to perform the computational simulation, to establish bounds on interfacial bond strength and to interpret interfacial bond quality.

  11. Three-dimensional dynamic thermal imaging of structural flaws by dual-band infrared computed tomography

    SciTech Connect

    Del Grande, N.K.; Dolan, K.W.; Durbin, P.F.; Gorvad, M.R.; Kornblum, B.T.; Perkins, D.E.; Schneberk, D.J.; Shapiro, A.B.

    1993-04-01

    We discuss three-dimensional (3D) dynamic thermal imaging of structure flaws using dual-band infrared (DBIR) computed tomography. Conventional thermography provides single-band infrared images which are difficult to interpret. Standard procedures yield imprecise (or qualitative) information about subsurface flaw sites which are typically masked by surface clutter. We use a DBIR imaging unique pioneered at LLNL to capture the time history of surface temperature difference for flash-heated targets. We relate these patterns to the location, size, shape and depth of subsurface flaws. We have demonstrated temperature accuracies of 0.2{degree}C, timing synchronizations of 3 ms (after onset of heat flash) and intervals of 42 ms, between images, during an 8 s cooling (and hearing) interval characterizing the front (and back) surface temperature-time history of an epoxy-glue disbond site in a flash-heated aluminum lap joint. This type of disbond played a significant role in causing damage to the Aloha Aircraft fuselage on the aged Boeing 737 jetliner. By ratioing DBIR images (near 5 and 10 micron), we located surface temperature patterns (generated by weak heat flow anomalies at subsurface flaw sites) and removed the emissivity mask (from surface roughness variations). We compared measurements with calculations from the three-dimensional, finite element computer code: TOPAZ3D. We combined infrared, ultrasound and x-ray imaging methods to characterize the lap joint disbond site spatial, bond quality, and material differences.

  12. Computational Simulation of Damage Propagation in Three-Dimensional Woven Composites

    NASA Technical Reports Server (NTRS)

    Huang, Dade; Minnetyan, Levon

    2005-01-01

    Three dimensional (3D) woven composites have demonstrated multi-directional properties and improved transverse strength, impact resistance, and shear characteristics. The objective of this research is to develop a new model for predicting the elastic constants, hygrothermal effects, thermomechanical response, and stress limits of 3D woven composites; and to develop a computational tool to facilitate the evaluation of 3D woven composite structures with regard to damage tolerance and durability. Fiber orientations of weave and braid patterns are defined with reference to composite structural coordinates. Orthotropic ply properties and stress limits computed via micromechanics are transformed to composite structural coordinates and integrated to obtain the 3D properties. The various stages of degradation, from damage initiation to collapse of structures, in the 3D woven structures are simulated for the first time. Three dimensional woven composite specimens with various woven patterns under different loading conditions, such as tension, compression, bending, and shear are simulated in the validation process of this research. Damage initiation, growth, accumulation, and propagation to fracture are included in these simulations.

  13. Three-dimensional range data compression using computer graphics rendering pipeline.

    PubMed

    Zhang, Song

    2012-06-20

    This paper presents the idea of naturally encoding three-dimensional (3D) range data into regular two-dimensional (2D) images utilizing computer graphics rendering pipeline. The computer graphics pipeline provides a means to sample 3D geometry data into regular 2D images, and also to retrieve the depth information for each sampled pixel. The depth information for each pixel is further encoded into red, green, and blue color channels of regular 2D images. The 2D images can further be compressed with existing 2D image compression techniques. By this novel means, 3D geometry data obtained by 3D range scanners can be instantaneously compressed into 2D images, providing a novel way of storing 3D range data into its 2D counterparts. We will present experimental results to verify the performance of this proposed technique.

  14. Computer-aided design and three-dimensional printing in the manufacturing of an ocular prosthesis.

    PubMed

    Ruiters, Sébastien; Sun, Yi; de Jong, Stéphan; Politis, Constantinus; Mombaerts, Ilse

    2016-04-27

    Restoring the facial appearance in acquired anophthalmos entails precision fitting of a customised ocular prosthesis. The fabrication is an artisanal process, and is primarily based on an impression of the anophthalmic cavity. This is usually achieved by the impression-moulding method, which, however, may introduce errors, resulting in a poorly fitted prosthesis. We developed a new method in the manufacturing of a customised ocular prosthesis based on computer-aided design and computer-aided manufacturing. An ocular prosthesis, based on a three-dimensional (3D) printed impression-free mould of the anophthalmic cavity, was successfully fitted in a 68-year-old male. To the best of our knowledge, this is the first case of a customised ocular prosthesis designed with the aid of 3D printing.

  15. Time domain computation of nonlinear diffraction loads upon three dimensional floating bodies

    SciTech Connect

    Ferrant, P.

    1995-12-31

    The diffraction of nonlinear regular waves of permanent form by three dimensional bodies is simulated numerically. The computation is based on a boundary integral equation method, with a mixed Euler-Lagrange approach for the time-stepping. The method is an extension of a previously developed linear time domain computational model for free surface flows (Ferrant 1993b). The behavior of the nonlinear model has first been tested on radiation and diffraction problems for submerged bodies, with satisfactory results (Ferrant 1994). In the present paper, the author reports on the extension of this model to the diffraction of nonlinear waves upon surface piercing bodies. Some numerical results obtained in the case of a bottom-mounted vertical cylinder in water of finite depth are presented and discussed.

  16. Hypertext and three-dimensional computer graphics in an all digital PC-based CAI workstation.

    PubMed Central

    Schwarz, D. L.; Wind, G. G.

    1991-01-01

    In the past several years there has been an enormous increase in the number of computer-assisted instructional (CAI) applications. Many medical educators and physicians have recognized the power and utility of hypertext. Some developers have incorporated simple diagrams, scanned monochrome graphics or still frame photographs from a laser disc or CD-ROM into their hypertext applications. These technologies have greatly increased the role of the microcomputer in education and training. There still remain numerous applications for these tools which are yet to be explored. One of these exciting areas involves the use of three-dimensional computer graphics. An all digital platform increases application portability. Images Figure 1 Figure 2 Figure 3 Figure 4 PMID:1807767

  17. Using three-dimensional microfluidic networks for solving computationally hard problems

    PubMed Central

    Chiu, Daniel T.; Pezzoli, Elena; Wu, Hongkai; Stroock, Abraham D.; Whitesides, George M.

    2001-01-01

    This paper describes the design of a parallel algorithm that uses moving fluids in a three-dimensional microfluidic system to solve a nondeterministically polynomial complete problem (the maximal clique problem) in polynomial time. This algorithm relies on (i) parallel fabrication of the microfluidic system, (ii) parallel searching of all potential solutions by using fluid flow, and (iii) parallel optical readout of all solutions. This algorithm was implemented to solve the maximal clique problem for a simple graph with six vertices. The successful implementation of this algorithm to compute solutions for small-size graphs with fluids in microchannels is not useful, per se, but does suggest broader application for microfluidics in computation and control. PMID:11248014

  18. A computational approach to continuum damping of Alfven waves in two and three-dimensional geometry

    SciTech Connect

    Koenies, Axel; Kleiber, Ralf

    2012-12-15

    While the usual way of calculating continuum damping of global Alfven modes is the introduction of a small artificial resistivity, we present a computational approach to the problem based on a suitable path of integration in the complex plane. This approach is implemented by the Riccati shooting method and it is shown that it can be transferred to the Galerkin method used in three-dimensional ideal magneto-hydrodynamics (MHD) codes. The new approach turns out to be less expensive with respect to resolution and computation time than the usual one. We present an application to large aspect ratio tokamak and stellarator equilibria retaining a few Fourier harmonics only and calculate eigenfunctions and continuum damping rates. These may serve as an input for kinetic MHD hybrid models making it possible to bypass the problem of having singularities on the path of integration on one hand and considering continuum damping on the other.

  19. Hypertext and Three-Dimensional Computer Graphics: A Powerful Teaching Team

    PubMed Central

    Schwarz, Daniel L.; Wind, Gary G.

    1990-01-01

    In an effort to combat the frustration experienced by educators and students alike with the volume of factual and practical information the student is expected to learn and apply, new medical teaching methods are being developed. Research in the field of adult education techniques has determined which teaching methods best maintain learner interest and result in the greatest knowledge retention. Electronic data processing technology allows for the rapid organization and specific acquisition of vast amounts of information. Personal computers have become powerful enough to provide simple high-level interactivity and brilliantly detailed graphic displays. The Center for Graphic Medical Communication seeks to combine multiple electronic modalities including three-dimensional computer garphics, animation, hypertext, video disk, CD-ROM and CD-I to maximize the effeciency of teaching and learning anatomical concepts. ImagesFigure 1Figure 2

  20. Vortex particle-in-cell method for three-dimensional viscous unbounded flow computations

    NASA Astrophysics Data System (ADS)

    Liu, Chung Ho; Doorly, Denis J.

    2000-01-01

    A new vortex particle-in-cell (PIC) method is developed for the computation of three-dimensional unsteady, incompressible viscous flow in an unbounded domain. The method combines the advantages of the Lagrangian particle methods for convection and the use of an Eulerian grid to compute the diffusion and vortex stretching. The velocity boundary conditions used in the method are of Dirichlet-type, and can be calculated using the vorticity field on the grid by the Biot-Savart equation. The present results for the propagation speed of the single vortex ring are in good agreement with the Saffman's model. The applications of the method to the head-on and head-off collisions of the two vortex rings show good agreement with the experimental and numerical literature. Copyright

  1. The Proteus Navier-Stokes code. [two and three dimensional computational fluid dynamics

    NASA Technical Reports Server (NTRS)

    Towne, Charles E.; Schwab, John R.

    1992-01-01

    An effort is currently underway at NASA Lewis to develop two and three dimensional Navier-Stokes codes, called Proteus, for aerospace propulsion applications. Proteus solves the Reynolds-averaged, unsteady, compressible Navier-Stokes equations in strong conservation law form. Turbulence is modeled using a Baldwin-Lomax based algebraic eddy viscosity model. In addition, options are available to solve thin layer or Euler equations, and to eliminate the energy equation by assuming constant stagnation enthalpy. An extensive series of validation cases have been run, primarily using the two dimensional planar/axisymmetric version of the code. Several flows were computed that have exact solution such as: fully developed channel and pipe flow; Couette flow with and without pressure gradients; unsteady Couette flow formation; flow near a suddenly accelerated flat plate; flow between concentric rotating cylinders; and flow near a rotating disk. The two dimensional version of the Proteus code has been released, and the three dimensional code is scheduled for release in late 1991.

  2. Recent advances in the solution of three-dimensional flow over wings with leading edge vortex separation

    NASA Technical Reports Server (NTRS)

    Johnson, F. T.; Tinoco, E. N.; Lu, P.; Epton, M. A.

    1979-01-01

    Recent advances in a panel method for the solution of three-dimensional flow about wing and wing-body combinations with leading-edge vortex separation are presented. These advances were achieved as part of an ultimately successful assault on two shortcomings of the method, namely convergence failures in seemingly random cases, and overprediction of lift coefficient for high aspect-ratio wings. Advances include the implementation of improved panel numerics for the purpose of eliminating the highly non-linear effects of ring vortices around doublet panel edges, and the development of a least squares procedure for damping vortex sheet geometry update instabilities. A variety of cases generated by the computer program implementing the method are presented. These cases are of two types. The first type consists of numerical studies, which verify the underlying mathematical assumptions of the method and moreover show that the results are strongly invariant with respect to such user dependent input as wing panel layout, initial sheet shape, sheet rollup, etc. The second type consists of cases run for the purpose of comparing computed results with experimental data, and these comparisons verify the underlying physical assumptions made by the method.

  3. An adaptive three-dimensional Cartesian approach for the parallel computation of inviscid flow about static and dynamic configurations

    NASA Astrophysics Data System (ADS)

    Hunt, Jason Daniel

    An adaptive three-dimensional Cartesian approach for the parallel computation of compressible flow about static and dynamic configurations has been developed and validated. This is a further step towards a goal that remains elusive for CFD codes: the ability to model complex dynamic-geometry problems in a quick and automated manner. The underlying flow-solution method solves the three-dimensional Euler equations using a MUSCL-type finite-volume approach to achieve higher-order spatial accuracy. The flow solution, either steady or unsteady, is advanced in time via a two-stage time-stepping scheme. This basic solution method has been incorporated into a parallel block-adaptive Cartesian framework, using a block-octtree data structure to represent varying spatial resolution, and to compute flow solutions in parallel. The ability to represent static geometric configurations has been introduced by cutting a geometric configuration out of a background block-adaptive Cartesian grid, then solving for the flow on the resulting volume grid. This approach has been extended for dynamic geometric configurations: components of a given configuration were permitted to independently move, according to prescribed rigid-body motion. Two flow-solver difficulties arise as a result of introducing static and dynamic configurations: small time steps; and the disappearance/appearance of cell volume during a time integration step. Both of these problems have been remedied through cell merging. The concept of cell merging and its implementation within the parallel block-adaptive method is described. While the parallelization of certain grid-generation and cell-cutting routines resulted from this work, the most significant contribution was developing the novel cell-merging paradigm that was incorporated into the parallel block-adaptive framework. Lastly, example simulations both to validate the developed method and to demonstrate its full capabilities have been carried out. A simple, steady

  4. Analytical computation of three-dimensional synthetic seismograms by Modal Summation: method, validation and applications

    NASA Astrophysics Data System (ADS)

    La Mura, Cristina; Gholami, Vahid; Panza, Giuliano F.

    2013-04-01

    In order to enable realistic and reliable earthquake hazard assessment and reliable estimation of the ground motion response to an earthquake, three-dimensional velocity models have to be considered. The propagation of seismic waves in complex laterally varying 3D layered structures is a complicated process. Analytical solutions of the elastodynamic equations for such types of media are not known. The most common approaches to the formal description of seismic wavefields in such complex structures are methods based on direct numerical solutions of the elastodynamic equations, e.g. finite-difference, finite-element method, and approximate asymptotic methods. In this work, we present an innovative methodology for computing synthetic seismograms, complete of the main direct, refracted, converted phases and surface waves in three-dimensional anelastic models based on the combination of the Modal Summation technique with the Asymptotic Ray Theory in the framework of the WKBJ - approximation. The three - dimensional models are constructed using a set of vertically heterogeneous sections (1D structures) that are juxtaposed on a regular grid. The distribution of these sections in the grid is done in such a way to fulfill the requirement of weak lateral inhomogeneity in order to satisfy the condition of applicability of the WKBJ - approximation, i.e. the lateral gradient of the parameters characterizing the 1D structure has to be small with respect to the prevailing wavelength. The new method has been validated comparing synthetic seismograms with the records available of three different earthquakes in three different regions: Kanto basin (Japan) triggered by the 1990 Odawara earthquake Mw= 5.1, Romanian territory triggered by the 30 May 1990 Vrancea intermediate-depth earthquake Mw= 6.9 and Iranian territory affected by the 26 December 2003 Bam earthquake Mw= 6.6. Besides the advantage of being a useful tool for assessment of seismic hazard and seismic risk reduction, it

  5. Three-Dimensional Computed Tomography as a Method for Finding Die Attach Voids in Diodes

    NASA Technical Reports Server (NTRS)

    Brahm, E. N.; Rolin, T. D.

    2010-01-01

    NASA analyzes electrical, electronic, and electromechanical (EEE) parts used in space vehicles to understand failure modes of these components. The diode is an EEE part critical to NASA missions that can fail due to excessive voiding in the die attach. Metallography, one established method for studying the die attach, is a time-intensive, destructive, and equivocal process whereby mechanical grinding of the diodes is performed to reveal voiding in the die attach. Problems such as die attach pull-out tend to complicate results and can lead to erroneous conclusions. The objective of this study is to determine if three-dimensional computed tomography (3DCT), a nondestructive technique, is a viable alternative to metallography for detecting die attach voiding. The die attach voiding in two- dimensional planes created from 3DCT scans was compared to several physical cross sections of the same diode to determine if the 3DCT scan accurately recreates die attach volumetric variability

  6. Three-dimensional information hierarchical encryption based on computer-generated holograms

    NASA Astrophysics Data System (ADS)

    Kong, Dezhao; Shen, Xueju; Cao, Liangcai; Zhang, Hao; Zong, Song; Jin, Guofan

    2016-12-01

    A novel approach for encrypting three-dimensional (3-D) scene information hierarchically based on computer-generated holograms (CGHs) is proposed. The CGHs of the layer-oriented 3-D scene information are produced by angular-spectrum propagation algorithm at different depths. All the CGHs are then modulated by different chaotic random phase masks generated by the logistic map. Hierarchical encryption encoding is applied when all the CGHs are accumulated one by one, and the reconstructed volume of the 3-D scene information depends on permissions of different users. The chaotic random phase masks could be encoded into several parameters of the chaotic sequences to simplify the transmission and preservation of the keys. Optical experiments verify the proposed method and numerical simulations show the high key sensitivity, high security, and application flexibility of the method.

  7. Three-dimensional scene encryption and display based on computer-generated holograms.

    PubMed

    Kong, Dezhao; Cao, Liangcai; Jin, Guofan; Javidi, Bahram

    2016-10-10

    An optical encryption and display method for a three-dimensional (3D) scene is proposed based on computer-generated holograms (CGHs) using a single phase-only spatial light modulator. The 3D scene is encoded as one complex Fourier CGH. The Fourier CGH is then decomposed into two phase-only CGHs with random distributions by the vector stochastic decomposition algorithm. Two CGHs are interleaved as one final phase-only CGH for optical encryption and reconstruction. The proposed method can support high-level nonlinear optical 3D scene security and complex amplitude modulation of the optical field. The exclusive phase key offers strong resistances of decryption attacks. Experimental results demonstrate the validity of the novel method.

  8. Simulation of radiation effects on three-dimensional computer optical memories

    NASA Technical Reports Server (NTRS)

    Moscovitch, M.; Emfietzoglou, D.

    1997-01-01

    A model was developed to simulate the effects of heavy charged-particle (HCP) radiation on the information stored in three-dimensional computer optical memories. The model is based on (i) the HCP track radial dose distribution, (ii) the spatial and temporal distribution of temperature in the track, (iii) the matrix-specific radiation-induced changes that will affect the response, and (iv) the kinetics of transition of photochromic molecules from the colored to the colorless isomeric form (bit flip). It is shown that information stored in a volume of several nanometers radius around the particle's track axis may be lost. The magnitude of the effect is dependent on the particle's track structure.

  9. Investigation and evaluation of a computer program to minimize three-dimensional flight time tracks

    NASA Technical Reports Server (NTRS)

    Parke, F. I.

    1981-01-01

    The program for the DC 8-D3 flight planning was slightly modified for the three dimensional flight planning for DC 10 aircrafts. Several test runs of the modified program over the North Atlantic and North America were made for verifying the program. While geopotential height and temperature were used in a previous program as meteorological data, the modified program uses wind direction and speed and temperature received from the National Weather Service. A scanning program was written to collect required weather information from the raw data received in a packed decimal format. Two sets of weather data, the 12-hour forecast and 24-hour forecast based on 0000 GMT, are used for dynamic processes in testruns. In order to save computing time only the weather data of the North Atlantic and North America is previously stored in a PCF file and then scanned one by one.

  10. Three-dimensional multislice helical computed tomography techniques for canine extra-hepatic portosystemic shunt assessment.

    PubMed

    Bertolini, Giovanna; Rolla, Edoardo C; Zotti, Alessandro; Caldin, Marco

    2006-01-01

    The purpose of the present study was to investigate the feasibility and usefulness of three-dimensional (3D) multislice computed tomography (CT) angiography with maximum intensity projection (MIP) and volume rendering (VR) in six dogs with clinical and sonographic findings suggestive of portosystemic shunt. Furthermore, we aimed to estimate the diameter of the portal vein and shunt vessels. MIP and VR reconstructions were performed for each patient and the origin and insertion of all shunt vessels were detected. In addition, 3D reconstructions allowed excellent depiction of vascular morphology and topography. All diagnoses and vessel measurements were confirmed by surgery. 3D multidetector CT angiography is a promising, noninvasive, and accurate method of evaluating dogs with suspected portosystemic shunts.

  11. Layer-oriented computer-generated holograms for three-dimensional display

    NASA Astrophysics Data System (ADS)

    Cao, Liangcai; Zhao, Yan; Zhang, Hao; Zong, Song; Kong, Dezhao; Jin, Guofan

    2016-09-01

    Depth cues and full-parallax are crucial issues in the calculation of computer-generated holograms (CGHs) for perfect holographic three-dimensional (3-D) display. In order to accelerate the speed of generating CGHs and improve the display quality, three layer-oriented methods are investigated in this paper. The first method is based on angularspectrum, which can provide accurate depth cues. The second method is based on inverse Fresnel diffraction layered holographic stereogram to provide accurate depth information as well as correct occlusion effect. The third method is proposed to generate zoomable 3-D CGHs using layer-based shifted Fresnel diffraction. Numerical simulations and optical experiments have demonstrated that the proposed methods can reconstruct quality 3-D images.

  12. Three-dimensional object motion and velocity estimation using a single computational RGB-D camera.

    PubMed

    Lee, Seungwon; Jeong, Kyungwon; Park, Jinho; Paik, Joonki

    2015-01-08

    In this paper, a three-dimensional (3D) object moving direction and velocity estimation method is presented using a dual off-axis color-filtered aperture (DCA)-based computational camera. Conventional object tracking methods provided only two-dimensional (2D) states of an object in the image for the target representation. The proposed method estimates depth information in the object region from a single DCA camera that transforms 2D spatial information into 3D model parameters of the object. We also present a calibration method of the DCA camera to estimate the entire set of camera parameters for a practical implementation. Experimental results show that the proposed DCA-based color and depth (RGB-D) camera can calculate the 3D object moving direction and velocity of a randomly moving object in a single-camera framework.

  13. Numerical computation of multishocked, three-dimensional supersonic flow fields with real gas effects.

    NASA Technical Reports Server (NTRS)

    Kutler, P.; Reinhardt, W. A.; Warming, R. F.

    1972-01-01

    A computational procedure is presented which is capable of determining the supersonic flow field surrounding three-dimensional wing-body configurations such as a delta-wing space shuttle. The governing equations in conservation-law form are solved by a finite difference method using a second-order noncentered algorithm between the body and the outermost shock wave, which is treated as a sharp discontinuity. Secondary shocks which form between these boundaries are captured automatically, and the intersection of these shocks with the bow shock posed no difficulty. Resulting flow fields about typical blunt nose shuttle-like configurations at angle of attack are presented. The differences between perfect and real gas effects for high Mach number flows are shown.

  14. A fast method to compute Three-Dimensional Infrared Radiative Transfer in non scattering medium

    NASA Astrophysics Data System (ADS)

    Makke, Laurent; Musson-Genon, Luc; Carissimo, Bertrand

    2014-05-01

    The Atmospheric Radiation field has seen the development of more accurate and faster methods to take into account absoprtion in participating media. Radiative fog appears with clear sky condition due to a significant cooling during the night, so scattering is left out. Fog formation modelling requires accurate enough method to compute cooling rates. Thanks to High Performance Computing, multi-spectral approach of Radiative Transfer Equation resolution is most often used. Nevertheless, the coupling of three-dimensionnal radiative transfer with fluid dynamics is very detrimental to the computational cost. To reduce the time spent in radiation calculations, the following method uses analytical absorption functions fitted by Sasamori (1968) on Yamamoto's charts (Yamamoto,1956) to compute a local linear absorption coefficient. By averaging radiative properties, this method eliminates the spectral integration. For an isothermal atmosphere, analytical calculations lead to an explicit formula between emissivities functions and linear absorption coefficient. In the case of cooling to space approximation, this analytical expression gives very accurate results compared to correlated k-distribution. For non homogeneous paths, we propose a two steps algorithm. One-dimensional radiative quantities and linear absorption coefficient are computed by a two-flux method. Then, three-dimensional RTE under the grey medium assumption is solved with the DOM. Comparisons with measurements of radiative quantities during ParisFOG field (2006) shows the cability of this method to handle strong vertical variations of pressure/temperature and gases concentrations.

  15. A computational investigation of the three-dimensional unsteady aerodynamics of Drosophila hovering and maneuvering.

    PubMed

    Ramamurti, Ravi; Sandberg, William C

    2007-03-01

    Three-dimensional unsteady computations of the flow past a fruit fly Drosophila under hovering and free flight conditions are computed. The kinematics of the wings and the body of the fruit fly are prescribed from experimental observations. The computed unsteady lift and thrust forces are validated with experimental results and are in excellent agreement. The unsteady aerodynamic origin of the time-varying yaw moment is identified. The differences in the kinematics between the right and the left wings show that subtle change in the stroke angle and deviation angle can result in the yaw moment for the turning maneuver. The computed yaw moment reaches a peak value at the beginning of the maneuver and remains positive throughout the remainder of the maneuver. The origin of the yaw moment is investigated by computing the center of pressures on each wing and the individual moment arms. This investigation leads to the conclusion that it is the forward force and a component of the lift force that combine to produce the turning moment while the side force alone produces the restoring torque during the maneuver. The vorticity shed from the wing's leading edge and the tips show a loop like structure that during stroke reversals pinches off into Lambda-like structures that have not been previously observed in the wakes of flapping fliers.

  16. Metopic synostosis: Measuring intracranial volume change following fronto-orbital advancement using three-dimensional photogrammetry.

    PubMed

    Freudlsperger, Christian; Steinmacher, Sahra; Bächli, Heidi; Somlo, Elek; Hoffmann, Jürgen; Engel, Michael

    2015-06-01

    There is still disagreement regarding the intracranial volumes of patients with metopic synostosis compared with healthy patients. This study aimed to compare the intracranial volume of children with metopic synostosis before and after surgery to an age- and sex-matched control cohort using three-dimensional (3D) photogrammetry. Eighteen boys with metopic synostosis were operated on using standardized fronto-orbital advancement. Frontal, posterior and total intracranial volumes were measured exactly 1 day pre-operatively and 10 days post-operatively, using 3D photogrammetry. To establish an age- and sex-matched control group, the 3D photogrammetric data of 634 healthy boys between the ages of 3 and 13 months were analyzed. Mean age at surgery was 9 months (SD 1.7). Prior to surgery, boys with metopic synostosis showed significantly reduced frontal and total intracranial volumes compared with the reference group, but similar posterior volumes. After surgery, frontal and total intracranial volumes did not differ statistically from the control group. As children with metopic synostosis showed significantly smaller frontal and total intracranial volumes compared with an age- and sex-matched control group, corrective surgery should aim to achieve volume expansion. Furthermore, 3D photogrammetry provides a valuable alternative to CT scans in the measurement of intracranial volume in children with metopic synostosis, which significantly reduces the amount of radiation exposure to the growing brain.

  17. [Congenital heart disease: Recent technical advances in three-dimensional echocardiography].

    PubMed

    Karsenty, Clement; Hadeed, Khaled; Acar, Philippe

    2017-01-04

    The recent technical advances allow the use in practice of three-dimensional echocardiography in children especially through the new high frequency matrix probe. It is difficult or even impossible to hold breathing during children' acquisition so to avoid motion full volume artifact, one beat and live 3D modes are suitable. 3D echocardiography is more accurate than 2D to assess the size, location, and relationship with surrounding structures of atrial and ventricular septal defects and thus helps in the therapeutic decision. 3D echocardiography enables to guide precisely percutaneous procedure. The morphology of the valve leaflets, chordal support apparatus, papillary muscle and the annulus are particularly well described in 3D and allows assessment of the regurgitation before repair and after as well for the common valve of the atrioventricular septal defect or in the Ebstein anomaly. Complex heart diseases such as double outlet right ventricle are suitable to a tridimensional assessment to plan surgical strategy. 3D printing, fusion imaging in cathlab and automated volume quantification embody recent innovations of new techniques in congenital heart disease.

  18. External Boundary Conditions for Three-Dimensional Problems of Computational Aerodynamics

    NASA Technical Reports Server (NTRS)

    Tsynkov, Semyon V.

    1997-01-01

    We consider an unbounded steady-state flow of viscous fluid over a three-dimensional finite body or configuration of bodies. For the purpose of solving this flow problem numerically, we discretize the governing equations (Navier-Stokes) on a finite-difference grid. The grid obviously cannot stretch from the body up to infinity, because the number of the discrete variables in that case would not be finite. Therefore, prior to the discretization we truncate the original unbounded flow domain by introducing some artificial computational boundary at a finite distance of the body. Typically, the artificial boundary is introduced in a natural way as the external boundary of the domain covered by the grid. The flow problem formulated only on the finite computational domain rather than on the original infinite domain is clearly subdefinite unless some artificial boundary conditions (ABC's) are specified at the external computational boundary. Similarly, the discretized flow problem is subdefinite (i.e., lacks equations with respect to unknowns) unless a special closing procedure is implemented at this artificial boundary. The closing procedure in the discrete case is called the ABC's as well. In this paper, we present an innovative approach to constructing highly accurate ABC's for three-dimensional flow computations. The approach extends our previous technique developed for the two-dimensional case; it employs the finite-difference counterparts to Calderon's pseudodifferential boundary projections calculated in the framework of the difference potentials method (DPM) by Ryaben'kii. The resulting ABC's appear spatially nonlocal but particularly easy to implement along with the existing solvers. The new boundary conditions have been successfully combined with the NASA-developed production code TLNS3D and used for the analysis of wing-shaped configurations in subsonic (including incompressible limit) and transonic flow regimes. As demonstrated by the computational experiments

  19. A spectral formalism for computing three-dimensional deformations due to surface loads. 1: Theory

    NASA Technical Reports Server (NTRS)

    Mitrovica, J. X.; Davis, J. L.; Shapiro, I. I.

    1994-01-01

    We outline a complete spectral formalism for computing high spatial resolution three-dimensional deformations arising from the surface mass loading of a spherically symmetric planet. The main advantages of the formalism are that all surface mass loads are always described using a consistent mathematical representation and that calculations of deformation fields for various spatial resolutions can be performed by simpley altering the spherical harmonic degree truncation level of the procedure. The latter may be important when incorporating improved observational constraints on a particular surface mass load, when considering potential errors in the computed field associated with mass loading having a spatial scale unresolved by the observational constraints, or when treating a number of global surface mass loads constrained with different spatial resolutions. The advantages do not extend to traditional 'Green's function' approaches which involve surface element discretizations of the global mass loads. Another advantage of the spectral formalism, over the Green's function approach, is that a posteriori analyses of the computed deformation fields are easily performed. In developing the spectral formalism, we consider specific cases where the Earth's mantle is assumed to respond as an elastic, slightly anelastic, or linear viscoelastic medium. In the case of an elastic or slightly anelastic mantle rheology the spectral response equations incorporate frequency dependent Love numbers. The formalism can therefore be used, for example, to compute the potentially resonant deformational response associated with the free core nutation and Chandler wobble eigenfunctions. For completeness, the spectral response equations include both body forces, as arise from the gravitational attraction of the Sun and the Moon, and surface mass loads. In either case, and for both elastic and anelastic mantle rheologies, we outline a pseudo-spectral technique for computing the ocean

  20. A practical implementation of turbulence models for the computation of three-dimensional separated flows

    NASA Technical Reports Server (NTRS)

    Marx, Yves P.

    1991-01-01

    An upwind MUSCL-type implicit scheme for the three-dimensional Navier-Stokes equations is presented and details on the implementation for three-dimensional flows of a 'diagonal' upwind implicit operator are developed. Turbulence models for separated flows are also described with an emphasis on the numerical specificities of the Johnson-King nonequilibrium model. Good predictions of separated two- and three-dimensional flows are demonstrated.

  1. High-speed data acquisition for three-dimensional x-ray and neutron computed tomography

    NASA Astrophysics Data System (ADS)

    Davis, Anthony W.; Claytor, Thomas N.; Sheats, Matthew J.

    1999-09-01

    Computed tomography for nondestructive evaluation applications has been limited by system cost, resolution, and time requirements for three-dimensional data sets. FlashCT (Flat panel Amorphous Silicon High-Resolution Computed Tomography) is a system developed at Los Alamos National Laboratory to address these three problems. Developed around a flat panel amorphous silicon detector array, FlashCT is suitable for low to medium energy x-ray and neutron computed tomography at 127- micron resolution. Overall system size is small, allowing rapid transportation to a variety of radiographic sources. System control software was developed in LabVIEW for Windows NT to allow multithreading of data acquisition, data correction, and staging motor control. The system control software simplifies data collection and allows fully automated control of the data acquisition process, leading toward remote or unattended operation. The first generation of the FlashCT Data Acquisition System was completed in August 1998, and since that time the system has been tested using x-ray sources ranging in energy from 60 kV to 20MV. The system has also been used to collect data for thermal neutron computed tomography at the Los Alamos Neutron Science Center (LANSCE). System improvements have been proposed to provide faster data collection and greater dynamic range during data collection.

  2. Turning intractable counting into sampling: Computing the configurational entropy of three-dimensional jammed packings

    NASA Astrophysics Data System (ADS)

    Martiniani, Stefano; Schrenk, K. Julian; Stevenson, Jacob D.; Wales, David J.; Frenkel, Daan

    2016-01-01

    We present a numerical calculation of the total number of disordered jammed configurations Ω of N repulsive, three-dimensional spheres in a fixed volume V . To make these calculations tractable, we increase the computational efficiency of the approach of Xu et al. [Phys. Rev. Lett. 106, 245502 (2011), 10.1103/PhysRevLett.106.245502] and Asenjo et al. [Phys. Rev. Lett. 112, 098002 (2014), 10.1103/PhysRevLett.112.098002] and we extend the method to allow computation of the configurational entropy as a function of pressure. The approach that we use computes the configurational entropy by sampling the absolute volume of basins of attraction of the stable packings in the potential energy landscape. We find a surprisingly strong correlation between the pressure of a configuration and the volume of its basin of attraction in the potential energy landscape. This relation is well described by a power law. Our methodology to compute the number of minima in the potential energy landscape should be applicable to a wide range of other enumeration problems in statistical physics, string theory, cosmology, and machine learning that aim to find the distribution of the extrema of a scalar cost function that depends on many degrees of freedom.

  3. Computational models for the analysis of three-dimensional internal and exhaust plume flowfields

    NASA Technical Reports Server (NTRS)

    Dash, S. M.; Delguidice, P. D.

    1977-01-01

    This paper describes computational procedures developed for the analysis of three-dimensional supersonic ducted flows and multinozzle exhaust plume flowfields. The models/codes embodying these procedures cater to a broad spectrum of geometric situations via the use of multiple reference plane grid networks in several coordinate systems. Shock capturing techniques are employed to trace the propagation and interaction of multiple shock surfaces while the plume interface, separating the exhaust and external flows, and the plume external shock are discretely analyzed. The computational grid within the reference planes follows the trace of streamlines to facilitate the incorporation of finite-rate chemistry and viscous computational capabilities. Exhaust gas properties consist of combustion products in chemical equilibrium. The computational accuracy of the models/codes is assessed via comparisons with exact solutions, results of other codes and experimental data. Results are presented for the flows in two-dimensional convergent and divergent ducts, expansive and compressive corner flows, flow in a rectangular nozzle and the plume flowfields for exhausts issuing out of single and multiple rectangular nozzles.

  4. High Speed Data Acquisition System for Three-Dimensional X-Ray and Neutron Computed Tomography

    SciTech Connect

    Davis, A.W.; Claytor, T.N.; Sheats, M.J.

    1999-07-01

    Computed tomography for nondestructive evaluation applications has been limited by system cost, resolution, and time requirements for three-dimensional data sets. FlashCT (Flat panel Amorphous Silicon High-Resolution Computed Tomography) is a system developed at Los Alamos National Laboratory to address these three problems. Developed around a flat panel amorphous silicon detector array, FlashCT is suitable for low to medium energy x-ray and neutron computed tomography at 127-micron resolution. Overall system size is small, allowing rapid transportation to a variety of radiographic sources. System control software was developed in LabVIEW for Windows NT to allow multithreading of data acquisition, data correction, and staging motor control. The system control software simplifies data collection and allows fully automated control of the data acquisition process, leading toward remote or unattended operation. The first generation of the FlashCT Data Acquisition System was completed in Au gust 1998, and since that time the system has been tested using x-ray sources ranging in energy from 60 kV to 20MV. The system has also been used to collect data for thermal neutron computed tomography at Los Alamos Neutron Science Center (LANSCE). System improvements have been proposed to provide faster data collection and greater dynamic range during data collection.

  5. Long-term three-dimensional stability of mandibular advancement surgery

    PubMed Central

    Franco, Alexandre A.; Cevidanes, Lucia Helena S.; Phillips, Ceib; Rossouw, Paul Emile; Turvey, Timothy A.; Carvalho, Felipe de Assis R.; de Paula, Leonardo K.; Quintão, Cátia Cardoso A.; Almeida, Marco Antonio O.

    2013-01-01

    PURPOSE To evaluate the three-dimensional changes in the position of the condyles, rami, and chin from 1 to 3 years after mandibular advancement surgery. METHOD This prospective observational study used pre and postoperative CBCT scans of 27 subjects with skeletal Class II jaw relationship and normal or deep overbite. An automatic technique of cranial base superimposition was used to assess positional and/or bone remodeling changes that were visually displayed and quantified using 3D color maps. An analysis of covariance with presence of genioplasty, age at the time of surgery, and sex as explanatory variables was used to estimate and test the adjusted mean changes for each region of interest. RESULTS The chin rotated downward and backwards between the 1 and 3 years post-surgery. Changes ≥ 2mm were observed in 17% of the cases. The mandibular condyles presented displacements and/or bone remodeling ≥ 2mm on the anterior surface (21% of the cases on the left and 13% on the right side), superior surfaces (8% on both sides) and lateral poles (17% on the left and 4% on the right side). The posterior borders of the rami exhibited symmetric lateral or rotational displacements in 4% of the cases. CONCLUSION In the hierarchy of surgical stability, mandibular advancement surgery is considered one of the most stable surgical procedures However, between 1 and 3 years post-surgery approximately 20% of the patients had 2-4 mm changes in the horizontal and vertical chin position, and/or changes in condylar position and adaptive bone remodeling. PMID:23769460

  6. Three-dimensional printing and computer navigation assisted hemipelvectomy for en bloc resection of osteochondroma

    PubMed Central

    Zhang, Yaqing; Wen, Lianjiang; Zhang, Jun; Yan, Guoliang; Zhou, Yue; Huang, Bo

    2017-01-01

    Abstract Rationale: Three-dimensional (3D) printed templates can be designed to match an individual's anatomy, allowing surgeons to refine preoperative planning. In addition, the use of computer navigation (NAV) is gaining popularity to improve surgical accuracy in the resection of pelvic tumors. However, its use in combination with 3D printing to assist complex pelvic tumor resection has not been reported. Patient concerns: A 36-year-old man presented with left-sided pelvic pain and a fast-growing mass. He also complained of a 3-month history of radiating pain and numbness in the lower left extremity. Diagnoses: A biopsy revealed an osteochondroma with malignant potential. This osteochondroma arises from the ilium and involves the sacrum and lower lumbar vertebrae. Interventions: Here, we describe a novel combined application of 3D printing and intraoperative NAV systems to guide hemipelvectomy for en-bloc resection of the osteochondroma. The 3D printed template is analyzed during surgical planning and guides the initial intraoperative bone work to improve surgical accuracy and efficiency, while a computer NAV system provides real-time imaging during the tumor removal to achieve adequate resection margins and minimize the likelihood of injury to adjacent critical structures. Outcomes: The tumor mass and the invaded spinal structures were removed en bloc. Lessons: The combined application of 3D printing and computer NAV may be useful for tumor targeting and safe osteotomies in pelvic tumor surgery. PMID:28328842

  7. Constructing three-dimensional detachable and composable computer models of the head and neck.

    PubMed

    Fan, Min; Dai, Peishan; Zheng, Buhong; Li, Xinchun

    2015-06-01

    The head and neck region has a complex spatial and topological structure, three-dimensional (3D) computer model of the region can be used in anatomical education, radiotherapy planning and surgical training. However, most of the current models only consist of a few parts of the head and neck, and the 3D models are not detachable and composable. In this study, a high-resolution 3D detachable and composable model of the head and neck was constructed based on computed tomography (CT) serial images. First, fine CT serial images of the head and neck were obtained. Then, a color lookup table was created for 58 structures, which was used to create anatomical atlases of the head and neck. Then, surface and volume rendering methods were used to reconstruct 3D models of the head and neck. Smoothing and polygon reduction steps were added to improve 3D rendering effects. 3D computer models of the head and neck, including the sinus, pharynx, vasculature, nervous system, endocrine system and glands, muscles, bones and skin, were reconstructed. The models consisted of 58 anatomical detachable and composable structures and each structure can be displayed individually or together with other structures.

  8. Improved depth perception with three-dimensional auxiliary display and computer generated three-dimensional panoramic overviews in robot-assisted laparoscopy

    PubMed Central

    Wieringa, Fokko P.; Bouma, Henri; Eendebak, Pieter T.; van Basten, Jean-Paul A.; Beerlage, Harrie P.; Smits, Geert A. H. J.; Bos, Jelte E.

    2014-01-01

    Abstract. In comparison to open surgery, endoscopic surgery offers impaired depth perception and narrower field-of-view. To improve depth perception, the Da Vinci robot offers three-dimensional (3-D) video on the console for the surgeon but not for assistants, although both must collaborate. We improved the shared perception of the whole surgical team by connecting live 3-D monitors to all three available Da Vinci generations, probed user experience after two years by questionnaire, and compared time measurements of a predefined complex interaction task performed with a 3-D monitor versus two-dimensional. Additionally, we investigated whether the complex mental task of reconstructing a 3-D overview from an endoscopic video can be performed by a computer and shared among users. During the study, 925 robot-assisted laparoscopic procedures were performed in three hospitals, including prostatectomies, cystectomies, and nephrectomies. Thirty-one users participated in our questionnaire. Eighty-four percent preferred 3-D monitors and 100% reported spatial-perception improvement. All participating urologists indicated quicker performance of tasks requiring delicate collaboration (e.g., clip placement) when assistants used 3-D monitors. Eighteen users participated in a timing experiment during a delicate cooperation task in vitro. Teamwork was significantly (40%) faster with the 3-D monitor. Computer-generated 3-D reconstructions from recordings offered very wide interactive panoramas with educational value, although the present embodiment is vulnerable to movement artifacts. PMID:26158026

  9. Improved depth perception with three-dimensional auxiliary display and computer generated three-dimensional panoramic overviews in robot-assisted laparoscopy.

    PubMed

    Wieringa, Fokko P; Bouma, Henri; Eendebak, Pieter T; van Basten, Jean-Paul A; Beerlage, Harrie P; Smits, Geert A H J; Bos, Jelte E

    2014-04-01

    In comparison to open surgery, endoscopic surgery offers impaired depth perception and narrower field-of-view. To improve depth perception, the Da Vinci robot offers three-dimensional (3-D) video on the console for the surgeon but not for assistants, although both must collaborate. We improved the shared perception of the whole surgical team by connecting live 3-D monitors to all three available Da Vinci generations, probed user experience after two years by questionnaire, and compared time measurements of a predefined complex interaction task performed with a 3-D monitor versus two-dimensional. Additionally, we investigated whether the complex mental task of reconstructing a 3-D overview from an endoscopic video can be performed by a computer and shared among users. During the study, 925 robot-assisted laparoscopic procedures were performed in three hospitals, including prostatectomies, cystectomies, and nephrectomies. Thirty-one users participated in our questionnaire. Eighty-four percent preferred 3-D monitors and 100% reported spatial-perception improvement. All participating urologists indicated quicker performance of tasks requiring delicate collaboration (e.g., clip placement) when assistants used 3-D monitors. Eighteen users participated in a timing experiment during a delicate cooperation task in vitro. Teamwork was significantly (40%) faster with the 3-D monitor. Computer-generated 3-D reconstructions from recordings offered very wide interactive panoramas with educational value, although the present embodiment is vulnerable to movement artifacts.

  10. Advanced treatment of wet-spun acrylic fiber manufacturing wastewater using three-dimensional electrochemical oxidation.

    PubMed

    Zheng, Tianlong; Wang, Qunhui; Shi, Zhining; Fang, Yue; Shi, Shanshan; Wang, Juan; Wu, Chuanfu

    2016-12-01

    A three-dimensional electrochemical oxidation (3D-EC) reactor with introduction of activated carbon (AC) as particle micro-electrodes was applied for the advanced treatment of secondary wastewater effluent of a wet-spun acrylic fiber manufacturing plant. Under the optimized conditions (current density of 500A/m(2), circulation rate of 5mL/min, AC dosage of 50g, and chloride concentration of 1.0g/L), the average removal efficiencies of chemical oxygen demand (CODcr), NH3-N, total organic carbon (TOC), and ultraviolet absorption at 254nm (UV254) of the 3D-EC reactor were 64.5%, 60.8%, 46.4%, and 64.8%, respectively; while the corresponding effluent concentrations of CODcr, NH3-N, TOC, and UV254 were 76.6, 20.1, and 42.5mg/L, and 0.08Abs/cm, respectively. The effluent concentration of CODcr was less than 100mg/L, which showed that the treated wastewater satisfied the demand of the integrated wastewater discharge standard (GB 8978-1996). The 3D-EC process remarkably improved the treatment efficiencies with synergistic effects for CODcr, NH3-N, TOC, and UV254 during the stable stage of 44.5%, 38.8%, 27.2%, and 10.9%, respectively, as compared with the sum of the efficiencies of a two-dimensional electrochemical oxidation (2D-EC) reactor and an AC adsorption process, which was ascribed to the numerous micro-electrodes of AC in the 3D-EC reactor. Gas chromatography mass spectrometry (GC-MS) analysis revealed that electrochemical treatment did not generate more toxic organics, and it was proved that the increase in acute biotoxicity was caused primarily by the production of free chlorine.

  11. Three-Dimensional Computational Fluid Dynamics Modeling of Solid Oxide Electrolysis Cells and Stacks

    SciTech Connect

    Grant Hawkes; James O'Brien; Carl Stoots; Stephen Herring

    2008-07-01

    A three-dimensional computational fluid dynamics (CFD) electrochemical model has been created for detailed analysis of a high-temperature electrolysis stack (solid oxide fuel cells operated as electrolyzers). Inlet and outlet plenum flow distributions are discussed. Maldistribution of plena flow show deviations in per-cell operating conditions due to non-uniformity of species concentrations. Models have also been created to simulate experimental conditions and for code validation. Comparisons between model predictions and experimental results are discussed. Mass, momentum, energy, and species conservation and transport are provided via the core features of the commercial CFD code FLUENT. A solid-oxide fuel cell (SOFC) model adds the electrochemical reactions and loss mechanisms and computation of the electric field throughout the cell. The FLUENT SOFC user-defined subroutine was modified for this work to allow for operation in the electrolysis mode. Model results provide detailed profiles of temperature, Nernst potential, operating potential, activation over-potential, anode-side gas composition, cathode-side gas composition, current density and hydrogen production over a range of stack operating conditions. Variations in flow distribution, and species concentration are discussed. End effects of flow and per-cell voltage are also considered. Predicted mean outlet hydrogen and steam concentrations vary linearly with current density, as expected. Contour plots of local electrolyte temperature, current density, and Nernst potential indicate the effects of heat transfer, reaction cooling/heating, and change in local gas composition.

  12. Computational Study of Effects of Tension Imbalance on Phonation in a Three Dimensional Tubular Larynx Model

    PubMed Central

    Xue, Qian; Zheng, Xudong; Mittal, Rajat; Bielamowicz, Steve

    2014-01-01

    Summary Objective The current study explores the use of a continuum based computational model to investigate the effect of left right tension imbalance on vocal fold vibrations and glottal aerodynamics, as well as its implication on phonation. The study allows us to gain new insights into the underlying physical mechanism of irregularities induced by vocal fold tension imbalance associated with unilateral cricothyroid muscle paralysis. Method A three dimensional simulation of glottal flow and vocal fold dynamics in a tubular laryngeal model with tension imbalance was conducted by using a coupled flow-structure interaction computational model. Tension imbalance was modeled by reducing by 20% the Young’s modulus of one of the vocal folds, while holding vocal fold length constant. Effects of tension imbalance on vibratory characteristic of the vocal folds and on the time-varying properties of glottal airflow as well as the aerodynamic energy transfer are comprehensively analyzed. Results and Conclusions The analysis demonstrates that the continuum based biomechanical model can provide a good description of phonatory dynamics in tension imbalance conditions. It is found that while 20% tension imbalance does not have noticeable effects on the fundamental frequency, it does lead to a larger glottal flow leakage and asymmetric vibrations of the two vocal folds. A detailed analysis of the energy transfer suggests that the majority of the energy is consumed by the lateral motion of the vocal folds and the net energy transferred to the softer fold is less than the one transferred to the normal fold. PMID:24725589

  13. Three-dimensional computer model for the atmospheric general circulation experiment

    NASA Technical Reports Server (NTRS)

    Roberts, G. O.

    1984-01-01

    An efficient, flexible, three-dimensional, hydrodynamic, computer code has been developed for a spherical cap geometry. The code will be used to simulate NASA's Atmospheric General Circulation Experiment (AGCE). The AGCE is a spherical, baroclinic experiment which will model the large-scale dynamics of our atmosphere; it has been proposed to NASA for future Spacelab flights. In the AGCE a radial dielectric body force will simulate gravity, with hot fluid tending to move outwards. In order that this force be dominant, the AGCE must be operated in a low gravity environment such as Spacelab. The full potential of the AGCE will only be realized by working in conjunction with an accurate computer model. Proposed experimental parameter settings will be checked first using model runs. Then actual experimental results will be compared with the model predictions. This interaction between experiment and theory will be very valuable in determining the nature of the AGCE flows and hence their relationship to analytical theories and actual atmospheric dynamics.

  14. Effects of using two- versus three-dimensional computational modeling of fluidized beds Part I, hydrodynamics

    SciTech Connect

    Xie, Nan; Battaglia, Francine; Pannala, Sreekanth

    2008-01-01

    Simulations of fluidized beds are performed to study and determine the effect on the use of coordinate systems and geometrical configurations to model fluidized bed reactors. Computational fluid dynamics is employed for an Eulerian-Eulerian model, which represents each phase as an interspersed continuum. The transport equation for granular temperature is solved and a hyperbolic tangent function is used to provide a smooth transition between the plastic and viscous regimes for the solid phase. The aim of the present work is to show the range of validity for employing simulations based on a 2D Cartesian coordinate system to approximate both cylindrical and rectangular fluidized beds. Three different fluidization regimes, bubbling, slugging and turbulent regimes, are investigated and the results of 2D and 3D simulations are presented for both cylindrical and rectangular domains. The results demonstrate that a 2D Cartesian system can be used to successfully simulate and predict a bubbling regime. However, caution must be exercised when using 2D Cartesian coordinates for other fluidized regimes. A budget analysis that explains all the differences in detail is presented in Part II [N. Xie, F. Battaglia, S. Pannala, Effects of Using Two-Versus Three-Dimensional Computational Modeling of Fluidized Beds: Part II, budget analysis, 182 (1) (2007) 14] to complement the hydrodynamic theory of this paper.

  15. Synchrotron X-ray computed laminography of the three-dimensional anatomy of tomato leaves.

    PubMed

    Verboven, Pieter; Herremans, Els; Helfen, Lukas; Ho, Quang T; Abera, Metadel; Baumbach, Tilo; Wevers, Martine; Nicolaï, Bart M

    2015-01-01

    Synchrotron radiation computed laminography (SR-CL) is presented as an imaging method for analyzing the three-dimensional (3D) anatomy of leaves. The SR-CL method was used to provide 3D images of 1-mm² samples of intact leaves at a pixel resolution of 750 nm. The method allowed visualization and quantitative analysis of palisade and spongy mesophyll cells, and showed local venation patterns, aspects of xylem vascular structure and stomata. The method failed to image subcellular organelles such as chloroplasts. We constructed 3D computer models of leaves that can provide a basis for calculating gas exchange, light penetration and water and solute transport. The leaf anatomy of two different tomato genotypes grown in saturating light conditions was compared by 3D analysis. Differences were found in calculated values of tissue porosity, cell number density, cell area to volume ratio and cell volume and cell shape distributions of palisade and spongy cell layers. In contrast, the exposed cell area to leaf area ratio in mesophyll, a descriptor that correlates to the maximum rate of photosynthesis in saturated light conditions, was no different between spongy and palisade cells or between genotypes. The use of 3D image processing avoids many of the limitations of anatomical analysis with two-dimensional sections.

  16. Three dimensional morphological studies of Larger Benthic Foraminifera at the population level using micro computed tomography

    NASA Astrophysics Data System (ADS)

    Kinoshita, Shunichi; Eder, Wolfgang; Woeger, Julia; Hohenegger, Johann; Briguglio, Antonino; Ferrandez-Canadell, Carles

    2015-04-01

    Symbiont-bearing larger benthic Foraminifera (LBF) are long-living marine (at least 1 year), single-celled organisms with complex calcium carbonate shells. Their morphology has been intensively studied since the middle of the nineteenth century. This led to a broad spectrum of taxonomic results, important from biostratigraphy to ecology in shallow water tropical to warm temperate marine palaeo-environments. However, it was necessary for the traditional investigation methods to cut or destruct specimens for analysing the taxonomically important inner structures. X-ray micro-computed tomography (microCT) is one of the newest techniques used in morphological studies. The greatest advantage is the non-destructive acquisition of inner structures. Furthermore, the running improve of microCT scanners' hard- and software provides high resolution and short time scans well-suited for LBF. Three-dimensional imaging techniques allow to select and extract each chamber and to measure easily its volume, surface and several form parameters used for morphometric analyses. Thus, 3-dimensional visualisation of LBF-tests is a very big step forward from traditional morphology based on 2-dimensional data. The quantification of chamber form is a great opportunity to tackle LBF structures, architectures and the bauplan geometry. The micrometric digital resolution is the only way to solve many controversies in phylogeny and evolutionary trends of LBF. For the present study we used micro-computed tomography to easily investigate the chamber number of every specimen from statistically representative part of populations to estimate population dynamics. Samples of living individuals are collected at monthly intervals from fixed locations. Specific preparation allows to scan up to 35 specimens per scan within 2 hours and to obtain the complete digital dataset for each specimen of the population. MicroCT enables thus a fast and precise count of all chambers built by the foraminifer from its

  17. Computational Aerodynamic Analysis of Three-Dimensional Ice Shapes on a NACA 23012 Airfoil

    NASA Technical Reports Server (NTRS)

    Jun, Garam; Oliden, Daniel; Potapczuk, Mark G.; Tsao, Jen-Ching

    2014-01-01

    The present study identifies a process for performing computational fluid dynamic calculations of the flow over full three-dimensional (3D) representations of complex ice shapes deposited on aircraft surfaces. Rime and glaze icing geometries formed on a NACA23012 airfoil were obtained during testing in the NASA Glenn Research Center's Icing Research Tunnel (IRT). The ice shape geometries were scanned as a cloud of data points using a 3D laser scanner. The data point clouds were meshed using Geomagic software to create highly accurate models of the ice surface. The surface data was imported into Pointwise grid generation software to create the CFD surface and volume grids. It was determined that generating grids in Pointwise for complex 3D icing geometries was possible using various techniques that depended on the ice shape. Computations of the flow fields over these ice shapes were performed using the NASA National Combustion Code (NCC). Results for a rime ice shape for angle of attack conditions ranging from 0 to 10 degrees and for freestream Mach numbers of 0.10 and 0.18 are presented. For validation of the computational results, comparisons were made to test results from rapid-prototype models of the selected ice accretion shapes, obtained from a separate study in a subsonic wind tunnel at the University of Illinois at Urbana-Champaign. The computational and experimental results were compared for values of pressure coefficient and lift. Initial results show fairly good agreement for rime ice accretion simulations across the range of conditions examined. The glaze ice results are promising but require some further examination.

  18. Computational Aerodynamic Analysis of Three-Dimensional Ice Shapes on a NACA 23012 Airfoil

    NASA Technical Reports Server (NTRS)

    Jun, GaRam; Oliden, Daniel; Potapczuk, Mark G.; Tsao, Jen-Ching

    2014-01-01

    The present study identifies a process for performing computational fluid dynamic calculations of the flow over full three-dimensional (3D) representations of complex ice shapes deposited on aircraft surfaces. Rime and glaze icing geometries formed on a NACA23012 airfoil were obtained during testing in the NASA Glenn Research Centers Icing Research Tunnel (IRT). The ice shape geometries were scanned as a cloud of data points using a 3D laser scanner. The data point clouds were meshed using Geomagic software to create highly accurate models of the ice surface. The surface data was imported into Pointwise grid generation software to create the CFD surface and volume grids. It was determined that generating grids in Pointwise for complex 3D icing geometries was possible using various techniques that depended on the ice shape. Computations of the flow fields over these ice shapes were performed using the NASA National Combustion Code (NCC). Results for a rime ice shape for angle of attack conditions ranging from 0 to 10 degrees and for freestream Mach numbers of 0.10 and 0.18 are presented. For validation of the computational results, comparisons were made to test results from rapid-prototype models of the selected ice accretion shapes, obtained from a separate study in a subsonic wind tunnel at the University of Illinois at Urbana-Champaign. The computational and experimental results were compared for values of pressure coefficient and lift. Initial results show fairly good agreement for rime ice accretion simulations across the range of conditions examined. The glaze ice results are promising but require some further examination.

  19. Locally Advanced Prostate Cancer: Three-Dimensional Magnetic Resonance Spectroscopy to Monitor Prostate Response to Therapy

    SciTech Connect

    Valentini, Anna Lia; Gui, Benedetta; D'Agostino, Giuseppe Roberto; Mattiucci, Giancarlo; Clementi, Valeria; Di Molfetta, Ippolita Valentina; Bonomo, Pierluigi; Mantini, Giovanna

    2012-11-01

    Purpose: To correlate results of three-dimensional magnetic resonance spectroscopic imaging (MRSI) with prostate-specific antigen (PSA) levels and time since external beam irradiation (EBRT) in patients treated with long-term hormone therapy (HT) and EBRT for locally advanced disease to verify successful treatment by documenting the achievement of metabolic atrophy (MA). Methods and Materials: Between 2006 and 2008, 109 patients were consecutively enrolled. MA was assessed by choline and citrate peak area-to-noise-ratio <5:1. Cancerous metabolism (CM) was defined by choline-to-creatine ratio >1.5:1 or choline signal-to-noise-ratio >5:1. To test the strength of association between MRSI results and the time elapsed since EBRT (TEFRT), PSA levels, Gleason score (GS), and stage, logistic regression (LR) was performed. p value <0.05 was statistically significant. The patients' outcomes were verified in 2011. Results: MRSI documented MA in 84 of 109 and CM in 25 of 109 cases. LR showed that age, GS, stage, and initial and recent PSA had no significant impact on MRSI results which were significantly related to PSA values at the time of MRSI and to TEFRT. Patients were divided into three groups according to TEFRT: <1 year, 1-2 years, and >2 years. MA was detected in 54.1% of patients of group 1, 88.9% of group 2, and in 94.5% of group 3 (100% when PSA nadir was reached). CM was detected in 50% of patients with reached PSA nadir in group 1. Local relapse was found in 3 patients previously showing CM at long TEFRT. Conclusion: MA detection, indicative of successful treatment because growth of normal or abnormal cells cannot occur without metabolism, increases with decreasing PSA levels and increasing time on HT after EBRT. This supports long-term HT in advanced prostate cancer. Larger study series are needed to assess whether MRSI could predict local relapse by detecting CM at long TEFRT.

  20. Three-dimensional reconstruction of subject-specific knee joint using computed tomography and magnetic resonance imaging image data fusions.

    PubMed

    Dong, Yuefu; Mou, Zhifang; Huang, Zhenyu; Hu, Guanghong; Dong, Yinghai; Xu, Qingrong

    2013-10-01

    Three-dimensional reconstruction of human body from a living subject can be considered as the first step toward promoting virtual human project as a tool in clinical applications. This study proposes a detailed protocol for building subject-specific three-dimensional model of knee joint from a living subject. The computed tomography and magnetic resonance imaging image data of knee joint were used to reconstruct knee structures, including bones, skin, muscles, cartilages, menisci, and ligaments. They were fused to assemble the complete three-dimensional knee joint. The procedure was repeated three times with respect to three different methods of reference landmarks. The accuracy of image fusion in accordance with different landmarks was evaluated and compared with each other. The complete three-dimensional knee joint, which included 21 knee structures, was accurately developed. The choice of external or anatomical landmarks was not crucial to improve image fusion accuracy for three-dimensional reconstruction. Further work needs to be done to explore the value of the reconstructed three-dimensional knee joint for its biomechanics and kinematics.

  1. Percutaneous Transcatheter Mitral Valve Replacement: Patient-specific Three-dimensional Computer-based Heart Model and Prototyping.

    PubMed

    Vaquerizo, Beatriz; Theriault-Lauzier, Pascal; Piazza, Nicolo

    2015-12-01

    Mitral regurgitation is the most prevalent valvular heart disease worldwide. Despite the widespread availability of curative surgical intervention, a considerable proportion of patients with severe mitral regurgitation are not referred for treatment, largely due to the presence of left ventricular dysfunction, advanced age, and comorbid illnesses. Transcatheter mitral valve replacement is a promising therapeutic alternative to traditional surgical valve replacement. The complex anatomical and pathophysiological nature of the mitral valvular complex, however, presents significant challenges to the successful design and implementation of novel transcatheter mitral replacement devices. Patient-specific 3-dimensional computer-based models enable accurate assessment of the mitral valve anatomy and preprocedural simulations for transcatheter therapies. Such information may help refine the design features of novel transcatheter mitral devices and enhance procedural planning. Herein, we describe a novel medical image-based processing tool that facilitates accurate, noninvasive assessment of the mitral valvular complex, by creating precise three-dimensional heart models. The 3-dimensional computer reconstructions are then converted to a physical model using 3-dimensional printing technology, thereby enabling patient-specific assessment of the interaction between device and patient. It may provide new opportunities for a better understanding of the mitral anatomy-pathophysiology-device interaction, which is of critical importance for the advancement of transcatheter mitral valve replacement.

  2. A computational model to generate simulated three-dimensional breast masses

    SciTech Connect

    Sisternes, Luis de; Brankov, Jovan G.; Zysk, Adam M.; Wernick, Miles N.; Schmidt, Robert A.; Nishikawa, Robert M.

    2015-02-15

    Purpose: To develop algorithms for creating realistic three-dimensional (3D) simulated breast masses and embedding them within actual clinical mammograms. The proposed techniques yield high-resolution simulated breast masses having randomized shapes, with user-defined mass type, size, location, and shape characteristics. Methods: The authors describe a method of producing 3D digital simulations of breast masses and a technique for embedding these simulated masses within actual digitized mammograms. Simulated 3D breast masses were generated by using a modified stochastic Gaussian random sphere model to generate a central tumor mass, and an iterative fractal branching algorithm to add complex spicule structures. The simulated masses were embedded within actual digitized mammograms. The authors evaluated the realism of the resulting hybrid phantoms by generating corresponding left- and right-breast image pairs, consisting of one breast image containing a real mass, and the opposite breast image of the same patient containing a similar simulated mass. The authors then used computer-aided diagnosis (CAD) methods and expert radiologist readers to determine whether significant differences can be observed between the real and hybrid images. Results: The authors found no statistically significant difference between the CAD features obtained from the real and simulated images of masses with either spiculated or nonspiculated margins. Likewise, the authors found that expert human readers performed very poorly in discriminating their hybrid images from real mammograms. Conclusions: The authors’ proposed method permits the realistic simulation of 3D breast masses having user-defined characteristics, enabling the creation of a large set of hybrid breast images containing a well-characterized mass, embedded within real breast background. The computational nature of the model makes it suitable for detectability studies, evaluation of computer aided diagnosis algorithms, and

  3. Three-dimensional computational fluid dynamics simulations of particle deposition in the tracheobronchial tree.

    PubMed

    Isaacs, Kristin K; Schlesinger, R B; Martonen, Ted B

    2006-01-01

    Simulation of the dynamics and disposition of inhaled particles within human lungs is an invaluable tool in both the development of inhaled pharmacologic drugs and the risk assessment of environmental particulate matter (PM). The goal of the present focused study was to assess the utility of three-dimensional computational fluid dynamics (CFD) models in studying the local deposition patterns of PM in respiratory airways. CFD models were validated using data from published experimental studies in human lung casts. The ability of CFD to appropriately simulate trends in deposition patterns due to changing ventilatory conditions was specifically addressed. CFD simulations of airflow and particle motion were performed in a model of the trachea and main bronchi using Fluent Inc.'s FIDAP CFD software. Particle diameters of 8 microm were considered for input flow rates of 15 and 60 L/min. CFD was able to reproduce the observed spatial heterogeneities of deposition within the modeled bifurcations, and correctly predicted the "hot-spots" of particle deposition on carinal ridges. The CFD methods also predicted observed differences in deposition for high-versus-low flow rates. CFD models may provide an efficient means of studying the complex effects of airway geometry, particle characteristics, and ventilatory parameters on particle deposition and therefore aid in the design of human subject experiments.

  4. Cellular Nutrition in Complex Three-Dimensional Scaffolds: A Comparison between Experiments and Computer Simulations.

    PubMed

    Bergemann, Claudia; Elter, Patrick; Lange, Regina; Weißmann, Volker; Hansmann, Harald; Klinkenberg, Ernst-Dieter; Nebe, Barbara

    2015-01-01

    Studies on bone cell ingrowth into synthetic, porous three-dimensional (3D) implants showed difficulties arising from impaired cellular proliferation and differentiation in the core region of these scaffolds with increasing scaffold volume in vitro. Therefore, we developed an in vitro perfusion cell culture module, which allows the analysis of cells in the interior of scaffolds under different medium flow rates. For each flow rate the cell viability was measured and compared with results from computer simulations that predict the local oxygen supply and shear stress inside the scaffold based on the finite element method. We found that the local cell viability correlates with the local oxygen concentration and the local shear stress. On the one hand the oxygen supply of the cells in the core becomes optimal with a higher perfusion flow. On the other hand shear stress caused by high flow rates impedes cell vitality, especially at the surface of the scaffold. Our results demonstrate that both parameters must be considered to derive an optimal nutrient flow rate.

  5. Quantitative assessment of myocardial perfusion using dynamic three-dimensional x-ray computed angiography

    SciTech Connect

    Teslow, T.N.

    1985-01-01

    Using computed tomogram time series, myocardial perfusion was angiographically measured as distributions of x-ray circulatory indicators in three dimensions. By separating the dynamic function from the cardiac structure, these separate components were tested using region-of-interest (ROI) mensuration in simulation, phantom, and in vivo experiments. Statistical criteria were used to evaluate the dynamic component which was represented by analytic mathematical models of indicator dilution. The spatial component was represented by three-dimensional (3-D) and two-dimensional (2-D) geometric models of the heart. Each of these components were determined in individual ROI's and globally integrated to manifest the perfusion heterogeneities. A physical heart phantom with controllable regional perfusion characteristics was also developed and studied. Experiments conducted on dogs compared the accuracy of 2-D and 3-D perfusion measurements by imaging to those using gamma-radioactive microspheres. Accurate reproducible localization of the heart was found to be important for obtaining accurate measures of regional perfusion in 3-D volume images exhibiting high noise.

  6. Three-dimensional time-dependent computer modeling of the electrothermal atomizers for analytical spectrometry

    NASA Astrophysics Data System (ADS)

    Tsivilskiy, I. V.; Nagulin, K. Yu.; Gilmutdinov, A. Kh.

    2016-02-01

    A full three-dimensional nonstationary numerical model of graphite electrothermal atomizers of various types is developed. The model is based on solution of a heat equation within solid walls of the atomizer with a radiative heat transfer and numerical solution of a full set of Navier-Stokes equations with an energy equation for a gas. Governing equations for the behavior of a discrete phase, i.e., atomic particles suspended in a gas (including gas-phase processes of evaporation and condensation), are derived from the formal equations molecular kinetics by numerical solution of the Hertz-Langmuir equation. The following atomizers test the model: a Varian standard heated electrothermal vaporizer (ETV), a Perkin Elmer standard THGA transversely heated graphite tube with integrated platform (THGA), and the original double-stage tube-helix atomizer (DSTHA). The experimental verification of computer calculations is carried out by a method of shadow spectral visualization of the spatial distributions of atomic and molecular vapors in an analytical space of an atomizer.

  7. Three-dimensional computational fluid dynamics for the Spallation Neutron Source liquid mercury target

    SciTech Connect

    Wendel, M.W.; Siman-Tov, M.

    1998-11-01

    The Spallation Neutron Source (SNS) is a high-power accelerator-based pulsed spallation source being designed by a multilaboratory team led by Oak Ridge National Laboratory (ORNL) to achieve high fluxes of neutrons for scientific experiments. Computational fluid dynamics (CFD) is being used to analyze the SNS design. The liquid-mercury target is subjected to the neutronic (internal) heat generation that results from the proton collisions with the mercury nuclei. The liquid mercury simultaneously serves as the neutronic target medium, transports away the heat generated within itself, and cools the metallic target structure. Recirculation and stagnation zones within the target are of particular concern because of the likelihood that they will result in local hot spots. These zones exist because the most feasible target designs include a complete U-turn flow redirection. Although the primary concern is that the target is adequately cooled, the pressure drop from inlet to outlet must also be considered because pressure drop directly affects structural loading and required pumping power. Based on the current design, a three-dimensional CFD model has been developed that includes the stainless steel target structure, the liquid-mercury target flow, and the liquid-mercury cooling jacket that wraps around the nose of the target.

  8. Comparison of Experimental Data and Computations Fluid Dynamics Analysis for a Three Dimensional Linear Plug Nozzle

    NASA Technical Reports Server (NTRS)

    Ruf, J. H.; Hagemann, G.; Immich, H.

    2003-01-01

    A three dimensional linear plug nozzle of area ratio 12.79 was designed by Astrium. The nozzle was tested within the German National Technology Program LION in a cold air wind tunnel by TU Dresden. The experimental hardware and test conditions are described. Experimental data was obtained for the nozzle without plug side wall fences and then with plug side wall fences. Experimental data for two nozzle pressure ratios (NPR), 116 and 45, are presented for the without fence and with fence configurations. Schlieren images of both NPR were recorded. Axial profiles of plug wall static pressures were measured at several spanwise locations and on the plug base. Detailed computational fluid dynamics (CFD) analysis was performed for these nozzle configurations by NASA MSFC. The CFD exhibits good agreement with the experimental data. A detailed comparison of the CFD results and the experimental plug wall pressure data is given for four test conditions; at both NPRs, without and with plug side wall fences. Numerical schlieren images are compared to experimental schlieren images. Nozzle thrust efficiencies are calculated from the CFD results. The CFD results are used to illustrate the plug nozzle fluid dynamics for all four test conditions. The effect of the plug side wall fences at both NPRs is emphasized.

  9. Affective three-dimensional brain-computer interface created using a prism array-based display

    NASA Astrophysics Data System (ADS)

    Mun, Sungchul; Park, Min-Chul

    2014-12-01

    To avoid the vergence-accommodation mismatch and provide a strong sense of presence to users, we applied a prism array-based display when presenting three-dimensional (3-D) objects. Emotional pictures were used as visual stimuli to increase the signal-to-noise ratios of steady-state visually evoked potentials (SSVEPs) because involuntarily motivated selective attention by affective mechanisms can enhance SSVEP amplitudes, thus producing increased interaction efficiency. Ten male and nine female participants voluntarily participated in our experiments. Participants were asked to control objects under three viewing conditions: two-dimension (2-D), stereoscopic 3-D, and prism. The participants performed each condition in a counter-balanced order. One-way repeated measures analysis of variance showed significant increases in the positive predictive values in the prism condition compared to the 2-D and 3-D conditions. Participants' subjective ratings of realness and engagement were also significantly greater in the prism condition than in the 2-D and 3-D conditions, while the ratings for visual fatigue were significantly reduced in the prism condition than in the 3-D condition. The proposed methods are expected to enhance the sense of reality in 3-D space without causing critical visual fatigue. In addition, people who are especially susceptible to stereoscopic 3-D may be able to use the affective brain-computer interface.

  10. Computational synthesis of ultrasound breast images from a three-dimensional anatomical model

    NASA Astrophysics Data System (ADS)

    Shen, Yi-Ting; Lacefield, James C.

    2005-04-01

    A three-dimensional breast anatomy model has been implemented using spline surfaces and fractal structures to represent the architecture of the lactiferous ducts, mammary fat lobules, skin, and supporting connective tissues. The model randomly varies user-specified structural parameters to provide an unlimited number of realizations of the gross anatomy. Cross-sectional views extracted by slicing through a realization of the model are input to a two-dimensional k-space (i.e., spatial frequency domain) ultrasound propagation simulator. The k-space simulator iterates pressure and particle velocity fields in 30-ns steps to compute scattering from the structures defined by the anatomical model and small random variations in compressibility that are added to generate speckle. A synthetic aperture method is employed to simulate B-mode imaging with a 5 MHz, 192-element linear array operated using multiple transmit focal zones and dynamic receive focusing. Simulated images of random-scattering phantoms possess approximately Rayleigh speckle statistics. The anatomical model is expected to yield images with speckle statistics comparable to clinical breast images. The long-term objectives of these simulations are to investigate sources of focus aberration in ultrasound breast imaging and the impact of aberration on cancer detection. [Work supported by an NSERC Discovery Grant.

  11. Fast three-dimensional superimposition of cone beam computed tomography for orthopaedics and orthognathic surgery evaluation

    PubMed Central

    Weissheimer, A.; Menezes, L. M.; Koerich, L.; Pham, J.; Cevidanes, L. H. S.

    2015-01-01

    The aim of this study was to validate a method for fast three-dimensional (3D) superimposition of cone beam computed tomography (CBCT) in growing patients and adults (surgical cases). The sample consisted of CBCT scans of 18 patients. For 10 patients, as the gold standard, the spatial position of the pretreatment CBCT was reoriented, saved as a reoriented volume, and then superimposed on the original image. For eight patients, four non-growing and four growing, the pre- and post-treatment scans were superimposed. Fast voxel-based superimposition was performed, with registration at the anterior cranial base. This superimposition process took 10–15 s. The fit of the cranial base superimposition was verified by qualitative visualization of the semi-transparent axial, sagittal, and coronal cross-sectional slices of all corresponding anatomical structures. Virtual 3D surface models of the skull were generated via threshold segmentation, and superimposition errors in the reoriented models and the results of treatment for the treated cases were evaluated by 3D surface distances on colour-coded maps. The superimposition error of the spatial reorientation and for growing and non-growing patients was <0.5 mm, which is acceptable and clinically insignificant. The voxel-based superimposition method evaluated was reproducible in different clinical conditions, rapid, and applicable for research and clinical practice. PMID:25935632

  12. The vomeronasal organ in the human embryo, studied by means of three-dimensional computer reconstruction

    PubMed Central

    SHERWOOD, REBECCA J.; MCLACHLAN, JOHN C.; AITON, JAMES F.; SCARBOROUGH, JULIE

    1999-01-01

    The human vomeronasal organ is of interest because of its potential role in sex pheromone detection. Due to the scarcity of early human material, studies of its development have concentrated on fetal rather than embryonic stages. The availability of embryonic specimens in the Walmsley Collection has enabled us to study the development of the vomeronasal organ (VNO) in human embryos between Carnegie Stages 17 and 23. Embryos at Carnegie Stage 17 or below showed no evidence of a VNO. One embryo with characteristics intermediate between Carnegie stages 17 and 18 was the earliest to show evidence of a VNO, in the form of a shallow indentation. All embryos at Carnegie Stages 18 or later had VNOs. Three-dimensional computer reconstructions were made of the VNO in each specimen where this was possible. This in part depended on the plane of section. The total volume and lumen volume were measured from these reconstructions and the volume of the vomeronasal epithelium was calculated by subtraction. A generally consistent increase in total volume and epithelial volume was observed with increasing developmental stage. The lumen contributed rather little to the total volume at these stages. PMID:10580856

  13. Fast three-dimensional superimposition of cone beam computed tomography for orthopaedics and orthognathic surgery evaluation.

    PubMed

    Weissheimer, A; Menezes, L M; Koerich, L; Pham, J; Cevidanes, L H S

    2015-09-01

    The aim of this study was to validate a method for fast three-dimensional (3D) superimposition of cone beam computed tomography (CBCT) in growing patients and adults (surgical cases). The sample consisted of CBCT scans of 18 patients. For 10 patients, as the gold standard, the spatial position of the pretreatment CBCT was reoriented, saved as a reoriented volume, and then superimposed on the original image. For eight patients, four non-growing and four growing, the pre- and post-treatment scans were superimposed. Fast voxel-based superimposition was performed, with registration at the anterior cranial base. This superimposition process took 10-15s. The fit of the cranial base superimposition was verified by qualitative visualization of the semi-transparent axial, sagittal, and coronal cross-sectional slices of all corresponding anatomical structures. Virtual 3D surface models of the skull were generated via threshold segmentation, and superimposition errors in the reoriented models and the results of treatment for the treated cases were evaluated by 3D surface distances on colour-coded maps. The superimposition error of the spatial reorientation and for growing and non-growing patients was <0.5mm, which is acceptable and clinically insignificant. The voxel-based superimposition method evaluated was reproducible in different clinical conditions, rapid, and applicable for research and clinical practice.

  14. Cellular Nutrition in Complex Three-Dimensional Scaffolds: A Comparison between Experiments and Computer Simulations

    PubMed Central

    Bergemann, Claudia; Elter, Patrick; Lange, Regina; Weißmann, Volker; Hansmann, Harald; Klinkenberg, Ernst-Dieter; Nebe, Barbara

    2015-01-01

    Studies on bone cell ingrowth into synthetic, porous three-dimensional (3D) implants showed difficulties arising from impaired cellular proliferation and differentiation in the core region of these scaffolds with increasing scaffold volume in vitro. Therefore, we developed an in vitro perfusion cell culture module, which allows the analysis of cells in the interior of scaffolds under different medium flow rates. For each flow rate the cell viability was measured and compared with results from computer simulations that predict the local oxygen supply and shear stress inside the scaffold based on the finite element method. We found that the local cell viability correlates with the local oxygen concentration and the local shear stress. On the one hand the oxygen supply of the cells in the core becomes optimal with a higher perfusion flow. On the other hand shear stress caused by high flow rates impedes cell vitality, especially at the surface of the scaffold. Our results demonstrate that both parameters must be considered to derive an optimal nutrient flow rate. PMID:26539216

  15. Three-dimensional helical computed tomographic evaluation of three obturation techniques: In vitro study

    PubMed Central

    Chokkalingam, M; Ramaprabha; Kandaswamy, D

    2011-01-01

    Aim: The purpose of this study was to evaluate the adequacy of three obturation techniques namely lateral condensation, EQ Fil (backfill obturation) and thermafil (core carrier obturation) techniques using three-dimensional (3D) helical computed tomography (CT) by volume rendering method. Materials and Methods: Thirty freshly extracted teeth were randomly divided into three groups of 10 teeth each. Biomechanical preparation was done in all the teeth using rotary instruments. All three sets of teeth were placed in helical CT slice scanner and were imaged before obturation. The three sets were then obturated by following methods: Group I: lateral condensation, Group II: EQ Fil (backfill) and Group III: thermafil (core carrier obturation).Volume of the pulp chamber and gutta-percha after obturation were calculated using volume rendering technique and adequacy of the obturation techniques were calculated. Statistical Analysis Used: One-way ANOVA and Multiple-Range Tukey Test by Tukey-HSD procedure Results: Mean change in lateral condensation (0.005±0.002) was significantly higher than that of thermafil obturation (0.002±0.001) [P<0.05]. Conclusions: Conventional lateral condensation technique showed maximal inadequacy of obturation and thermafil obturation technique showed the least inadequacy of obturation when the volume of the specimens were calculated and reconstructed PMID:22025832

  16. Anthropometry of the Human Scaphoid Waist by Three-Dimensional Computed Tomography.

    PubMed

    Smith, Jennifer; Hofmeister, Eric P; Renninger, Christopher; Kroonen, Leo T

    2015-01-01

    Published measurements for the scaphoid are scarce. The purpose of this study is to define anthropometric norms for the waist of the scaphoid to assist in optimizing bone graft quantity and implant use. Computed tomography images of the wrist were reviewed by three surgeons. Anthropometric data were gathered, including the scaphoid waist diameter in two dimensions and the scaphoid waist volume. Each study was measured twice, allowing for determination of inter- and intraobserver reliability. Forty-three studies were examined (23 female and 20 male). Average measurements of the scaphoid waist were 11.28 ± 0.26 mm in the sagittal plane and 8.70 ± 0.17 mm in the coronal plane, and the waist volume was 715 ± 33.0 mm3. Specific measures of the narrowest portion of the scaphoid are provided by this study. Measurements of the scaphoid waist through the use of three-dimensional imaging are an accurate method with good inter- and intraobserver reliability. The measurements obtained from this study can be applied to guide graft and implant selection for treatment of scaphoid waist fractures and nonunions.

  17. Accuracy and reliability of cetacean cranial measurements using computed tomography three dimensional volume rendered images

    PubMed Central

    Yuen, Adams Hei Long; Tsui, Henry Chun Lok; Kot, Brian Chin Wing

    2017-01-01

    Computed tomography (CT) has become more readily available for post-mortem examination, offering an alternative to cetacean cranial measurements obtained manually. Measurement error may result in possible variation in cranial morphometric analysis. This study aimed to evaluate the accuracy and reliability of cetacean cranial measurements obtained by CT three-dimensional volume rendered images (3DVRI). CT scans of 9 stranded cetaceans were performed. The acquired images were reconstructed using bone reconstruction algorithms. The reconstructed crania obtained by 3DVRI were visualized after excluding other body structures. Accuracy of cranial measurements obtained by CT 3DVRI was evaluated by comparing with that obtained by manual approach as standard of reference. Reproducibility and repeatability of cranial measurements obtained by CT 3DVRI were evaluated using intraclass correlation coefficient (ICC). The results demonstrated that cranial measurements obtained by CT 3DVRI yielded high accuracy (88.05%– 99.64%). High reproducibility (ICC ranged from 0.897 to 1.000) and repeatability (ICC ranged from 0.919 to 1.000 for operator 1 and ICC range from 0.768 to 1.000 for operator 2) were observed in cranial measurements obtained by CT 3DVRI. Therefore, cranial measurements obtained by CT 3DVRI could be considered as virtual alternative to conventional manual approach. This may help the development of a normative reference for current cranial maturity and discriminant analysis studies in cetaceans. PMID:28329016

  18. Building a three-dimensional model of the upper gastrointestinal tract for computer simulations of swallowing.

    PubMed

    Gastelum, Alfonso; Mata, Lucely; Brito-de-la-Fuente, Edmundo; Delmas, Patrice; Vicente, William; Salinas-Vázquez, Martín; Ascanio, Gabriel; Marquez, Jorge

    2016-03-01

    We aimed to provide realistic three-dimensional (3D) models to be used in numerical simulations of peristaltic flow in patients exhibiting difficulty in swallowing, also known as dysphagia. To this end, a 3D model of the upper gastrointestinal tract was built from the color cryosection images of the Visible Human Project dataset. Regional color heterogeneities were corrected by centering local histograms of the image difference between slices. A voxel-based model was generated by stacking contours from the color images. A triangle mesh was built, smoothed and simplified. Visualization tools were developed for browsing the model at different stages and for virtual endoscopy navigation. As result, a computer model of the esophagus and the stomach was obtained, mainly for modeling swallowing disorders. A central-axis curve was also obtained for virtual navigation and to replicate conditions relevant to swallowing disorders modeling. We show renderings of the model and discuss its use for simulating swallowing as a function of bolus rheological properties. The information obtained from simulation studies with our model could be useful for physicians in selecting the correct nutritional emulsions for patients with dysphagia.

  19. Bilateral and pseudobilateral tonsilloliths: Three dimensional imaging with cone-beam computed tomography

    PubMed Central

    Mısırlıoglu, Melda; Nalcaci, Rana; Yardımcı, Selmi

    2013-01-01

    Purpose Tonsilloliths are calcifications found in the crypts of the palatal tonsils and can be detected on routine panoramic examinations. This study was performed to highlight the benefits of cone-beam computed tomography (CBCT) in the diagnosis of tonsilloliths appearing bilaterally on panoramic radiographs. Materials and Methods The sample group consisted of 7 patients who had bilateral radiopaque lesions at the area of the ascending ramus on panoramic radiographs. CBCT images for every patient were obtained from both sides of the jaw to determine the exact locations of the lesions and to rule out other calcifications. The calcifications were evaluated on the CBCT images using Ez3D2009 software. Additionally, the obtained images in DICOM format were transferred to ITK SNAP 2.4.0 pc software for semiautomatic segmentation. Segmentation was performed using contrast differences between the soft tissues and calcifications on grayscale images, and the volume in mm3 of the segmented three dimensional models were obtained. Results CBCT scans revealed that what appeared on panoramic radiographs as bilateral images were in fact unilateral lesions in 2 cases. The total volume of the calcifications ranged from 7.92 to 302.5mm3. The patients with bilaterally multiple and large calcifications were found to be symptomatic. Conclusion The cases provided the evidence that tonsilloliths should be considered in the differential diagnosis of radiopaque masses involving the mandibular ramus, and they highlight the need for a CBCT scan to differentiate pseudo- or ghost images from true bilateral pathologies. PMID:24083209

  20. Three-dimensional radiation dose mapping with the TORT computer code

    SciTech Connect

    Slater, C.O.; Pace, J.V. III; Childs, R.L.; Haire, M.J. ); Koyama, T. )

    1991-01-01

    The Consolidated Fuel Reprocessing Program (CFRP) at Oak Ridge National Laboratory (ORNL) has performed radiation shielding studies in support of various facility designs for many years. Computer codes employing the point-kernel method have been used, and the accuracy of these codes is within acceptable limits. However, to further improve the accuracy and to calculate dose at a larger number of locations, a higher order method is desired, even for analyses performed in the early stages of facility design. Consequently, the three-dimensional discrete ordinates transport code TORT, developed at ORNL in the mid-1980s, was selected to examine in detail the dose received at equipment locations. The capabilities of the code have been previously reported. Recently, the Power Reactor and Nuclear Fuel Development Corporation in Japan and the US Department of Energy have used the TORT code as part of a collaborative agreement to jointly develop breeder reactor fuel reprocessing technology. In particular, CFRP used the TORT code to estimate radiation dose levels within the main process cell for a conceptual plant design and to establish process equipment lifetimes. The results reported in this paper are for a conceptual plant design that included the mechanical head and (i.e., the disassembly and shear machines), solvent extraction equipment, and miscellaneous process support equipment.

  1. Three-dimensional maxillary and mandibular regional superimposition using cone beam computed tomography: a validation study.

    PubMed

    Koerich, L; Burns, D; Weissheimer, A; Claus, J D P

    2016-05-01

    This study aimed to validate a novel method for fast regional superimposition of cone beam computed tomography (CBCT) scans. The method can be used with smaller field of view scans, thereby allowing for a lower radiation dose. This retrospective study used two dry skulls and secondary data from 15 patients who had more than one scan taken using the same machine. Two observers tested two types of regional voxel-based superimposition: maxillary and mandibular. The registration took 10-15s. Three-dimensional surface models of the maxillas and mandibles were generated via standardized threshold segmentation, and the accuracy and reproducibility of the superimpositions were assessed using the iterative closest point technique to measure the root mean square (RMS) distance between the images. Five areas were measured and a RMS≤0.25 was considered successful. Descriptive statistics and the intra-class correlation coefficient (ICC) were used to compare the intra-observer measurement reproducibility. The ICC was ≥0.980 for all of the variables and the highest RMS found was 0.241. The inter-observer reproducibility was assessed case by case and was perfect (RMS 0) for 68% (23 out of 34) of the superimpositions done and not clinically significant (RMS≤0.25) for the other 32%. The method is fast, accurate, and reproducible and is an alternative to cranial base superimposition.

  2. Anthropomorphic model observer performance in three-dimensional detection task for low-contrast computed tomography.

    PubMed

    Ba, Alexandre; Eckstein, Miguel P; Racine, Damien; Ott, Julien G; Verdun, Francis; Kobbe-Schmidt, Sabine; Bochud, François O

    2016-01-01

    X-ray medical imaging is increasingly becoming three-dimensional (3-D). The dose to the population and its management are of special concern in computed tomography (CT). Task-based methods with model observers to assess the dose-image quality trade-off are promising tools, but they still need to be validated for real volumetric images. The purpose of the present work is to evaluate anthropomorphic model observers in 3-D detection tasks for low-contrast CT images. We scanned a low-contrast phantom containing four types of signals at three dose levels and used two reconstruction algorithms. We implemented a multislice model observer based on the channelized Hotelling observer (msCHO) with anthropomorphic channels and investigated different internal noise methods. We found a good correlation for all tested model observers. These results suggest that the msCHO can be used as a relevant task-based method to evaluate low-contrast detection for CT and optimize scan protocols to lower dose in an efficient way.

  3. Three-Dimensional Characterization of Cell Clusters Using Synchrotron-Radiation-Based Micro-Computed Tomography

    NASA Astrophysics Data System (ADS)

    Müller, Ert; Riedel, Marco; Thurner, Philipp J.

    2006-04-01

    Micro-computed tomography with the highly intense, monochromatic X rays produced by the synchrotron is a superior method to nondestructively measure the local absorption in three-dimensional space. Because biological tissues and cells consist mainly of water as the surrounding medium, higher absorbing agents have to be incorporated into the structures of interest. Even without X-ray optics such as refractive lens, one can uncover the stain distribution with the spatial resolution of about 1 [mu]m. Incorporating the stain at selected cell compartments, for example, binding to the RNA/DNA, their density distribution becomes quantified. In this communication, we demonstrate that tomograms obtained at the beamlines BW2 and W2 (HASYLAB at DESY, Hamburg, Germany) and 4S (SLS, Villigen, Switzerland) clearly show that the RNA/DNA-stained HEK 293 cell clusters have a core of high density and a peripheral part of lower density, which correlate with results of optical microscopy. The inner part of the clusters is associated with nonvital cells as the result of insufficient oxygen and nutrition supply. This necrotic part is surrounded by (6 ± 1) layers of vital cells.

  4. Three-dimensional computed tomographic evaluation of Le Fort III distraction osteogenesis with an external device in syndromic craniosynostosis.

    PubMed

    Wery, M F; Nada, R M; van der Meulen, J J; Wolvius, E B; Ongkosuwito, E M

    2015-03-01

    There is little anteroposterior growth of the midface in patients with syndromic craniosynostosis who are followed up over time without intervention. A Le Fort III with distraction osteogenesis can be done to correct this. This is a controlled way in which to achieve appreciable stable advancement of the midface without the need for bone grafting, but the vector of the movement is not always predictable. The purpose of this study was to evaluate the 3-dimensional effect of Le Fort III distraction osteogenesis with an external frame. Ten patients (aged 7-19 years) who had the procedure were included in the study. The le Fort III procedure and the placement of the external frame were followed by an activation period and then a 3-month retention period. Computed tomographic (CT) images taken before and after operation were converted and loaded into 3-dimensional image rendering software and compared with the aid of a paired sample t test and a colour-coded qualitative analysis. Comparison of the CT data before and after distraction indicated that the amount of midface advancement was significant. Le Fort III distraction osteogenesis is an effective way to advance the midface. However, the movement during osteogenesis is not always exactly in the intended direction, and a secondary operation is often necessary. Three-dimensional evaluation over a longer period of time is necessary.

  5. A method for computation of inviscid three-dimensional flow over blunt bodies having large embedded subsonic regions

    NASA Technical Reports Server (NTRS)

    Weilmuenster, K. J.; Hamilton, H. H., II

    1981-01-01

    A computational technique for computing the three-dimensional inviscid flow over blunt bodies having large regions of embedded subsonic flow is detailed. Results, which were obtained using the CDC Cyber 203 vector processing computer, are presented for several analytic shapes with some comparison to experimental data. Finally, windward surface pressure computations over the first third of the Space Shuttle vehicle are compared with experimental data for angles of attack between 25 and 45 degrees.

  6. Diagnostic tools in maxillofacial fractures: Is there really a need of three-dimensional computed tomography?

    PubMed Central

    Shah, Sheerin; Uppal, Sanjeev K.; Mittal, Rajinder K.; Garg, Ramneesh; Saggar, Kavita; Dhawan, Rishi

    2016-01-01

    Introduction: Because of its functional and cosmetic importance, facial injuries, especially bony fractures are clinically very significant. Missed and maltreated fractures might result in malocclusion and disfigurement of the face, thus making accurate diagnosis of the fracture very essential. In earlier times, conventional radiography along with clinical examination played a major role in diagnosis of maxillofacial fractures. However, it was noted that the overlapping nature of bones and the inability to visualise soft tissue swelling and fracture displacement, especially in face, makes radiography less reliable and useful. Computed tomography (CT), also called as X-ray computed radiography, has helped in solving this problem. This clinical study is to compare three-dimensional (3D) CT reconstruction with conventional radiography in evaluating the maxillofacial fractures preoperatively and effecting the surgical management, accordingly. Materials and Methods: Fifty patients, with suspected maxillofacial fractures on clinical examination, were subjected to conventional radiography and CT face with 3D reconstruction. The number and site of fractures in zygoma, maxilla, mandible and nose, detected by both the methods, were enumerated and compared. The final bearing of these additional fractures, on the management protocol, was analysed. Results: CT proved superior to conventional radiography in diagnosing additional number of fractures in zygoma, maxilla, mandible (subcondylar) and nasal bone. Coronal and axial images were found to be significantly more diagnostic in fracture sites such as zygomaticomaxillary complex, orbital floor, arch, lateral maxillary wall and anterior maxillary wall. Conclusion: 3D images gave an inside out picture of the actual sites of fractures. It acted as mind's eye for pre-operative planning and intra-operative execution of surgery. Better surgical treatment could be given to 33% of the cases because of better diagnostic ability of CT

  7. Parallel computation of three-dimensional flows using overlapping grids with adaptive mesh refinement

    NASA Astrophysics Data System (ADS)

    Henshaw, William D.; Schwendeman, Donald W.

    2008-08-01

    This paper describes an approach for the numerical solution of time-dependent partial differential equations in complex three-dimensional domains. The domains are represented by overlapping structured grids, and block-structured adaptive mesh refinement (AMR) is employed to locally increase the grid resolution. In addition, the numerical method is implemented on parallel distributed-memory computers using a domain-decomposition approach. The implementation is flexible so that each base grid within the overlapping grid structure and its associated refinement grids can be independently partitioned over a chosen set of processors. A modified bin-packing algorithm is used to specify the partition for each grid so that the computational work is evenly distributed amongst the processors. All components of the AMR algorithm such as error estimation, regridding, and interpolation are performed in parallel. The parallel time-stepping algorithm is illustrated for initial-boundary-value problems involving a linear advection-diffusion equation and the (nonlinear) reactive Euler equations. Numerical results are presented for both equations to demonstrate the accuracy and correctness of the parallel approach. Exact solutions of the advection-diffusion equation are constructed, and these are used to check the corresponding numerical solutions for a variety of tests involving different overlapping grids, different numbers of refinement levels and refinement ratios, and different numbers of processors. The problem of planar shock diffraction by a sphere is considered as an illustration of the numerical approach for the Euler equations, and a problem involving the initiation of a detonation from a hot spot in a T-shaped pipe is considered to demonstrate the numerical approach for the reactive case. For both problems, the accuracy of the numerical solutions is assessed quantitatively through an estimation of the errors from a grid convergence study. The parallel performance of the

  8. Generalization of Spatial Channel Theory to Three-Dimensional x-y-z Transport Computations

    SciTech Connect

    I. K. Abu-Shumays; M. A. Hunter; R. L. Martz; J. M. Risner

    2002-03-12

    Spatial channel theory, initially introduced in 1977 by M. L. Williams and colleagues at ORNL, is a powerful tool for shield design optimization. It focuses on so called ''contributon'' flux and current of particles (a fraction of the total of neutrons, photons, etc.) which contribute directly or through their progeny to a pre-specified response, such as a detector reading, dose rate, reaction rate, etc., at certain locations of interest. Particles that do not contribute directly or indirectly to the pre-specified response, such as particles that are absorbed or leak out, are ignored. Contributon fluxes and currents are computed based on combined forward and adjoint transport solutions. The initial concepts were considerably improved by Abu-Shumays, Selva, and Shure by introducing steam functions and response flow functions. Plots of such functions provide both qualitative and quantitative information on dominant particle flow paths and identify locations within a shield configuration that are important in contributing to the response of interest. Previous work was restricted to two dimensional (2-D) x-y rectangular and r-z cylindrical geometries. This paper generalizes previous work to three-dimensional x-y-z geometry, since it is now practical to solve realistic 3-D problems with multidimensional transport programs. As in previous work, new analytic expressions are provided for folding spherical harmonics representations of forward and adjoint transport flux solutions. As a result, the main integrals involve in spatial channel theory are computed exactly and more efficiently than by numerical quadrature. The analogy with incompressible fluid flow is also applied to obtain visual qualitative and quantitative measures of important streaming paths that could prove vital for shield design optimization. Illustrative examples are provided. The connection between the current paper and the excellent work completed by M. L. Williams in 1991 is also discussed.

  9. Parallel Computation of Three-Dimensional Flows using Overlapping Grids with Adaptive Mesh Refinement

    SciTech Connect

    Henshaw, W; Schwendeman, D

    2007-11-15

    This paper describes an approach for the numerical solution of time-dependent partial differential equations in complex three-dimensional domains. The domains are represented by overlapping structured grids, and block-structured adaptive mesh refinement (AMR) is employed to locally increase the grid resolution. In addition, the numerical method is implemented on parallel distributed-memory computers using a domain-decomposition approach. The implementation is flexible so that each base grid within the overlapping grid structure and its associated refinement grids can be independently partitioned over a chosen set of processors. A modified bin-packing algorithm is used to specify the partition for each grid so that the computational work is evenly distributed amongst the processors. All components of the AMR algorithm such as error estimation, regridding, and interpolation are performed in parallel. The parallel time-stepping algorithm is illustrated for initial-boundary-value problems involving a linear advection-diffusion equation and the (nonlinear) reactive Euler equations. Numerical results are presented for both equations to demonstrate the accuracy and correctness of the parallel approach. Exact solutions of the advection-diffusion equation are constructed, and these are used to check the corresponding numerical solutions for a variety of tests involving different overlapping grids, different numbers of refinement levels and refinement ratios, and different numbers of processors. The problem of planar shock diffraction by a sphere is considered as an illustration of the numerical approach for the Euler equations, and a problem involving the initiation of a detonation from a hot spot in a T-shaped pipe is considered to demonstrate the numerical approach for the reactive case. For both problems, the solutions are shown to be well resolved on the finest grid. The parallel performance of the approach is examined in detail for the shock diffraction problem.

  10. Examination of the three-dimensional geometry of cetacean flukes using computed tomography scans: hydrodynamic implications.

    PubMed

    Fish, Frank E; Beneski, John T; Ketten, Darlene R

    2007-06-01

    The flukes of cetaceans function in the hydrodynamic generation of forces for thrust, stability, and maneuverability. The three-dimensional geometry of flukes is associated with production of lift and drag. Data on fluke geometry were collected from 19 cetacean specimens representing eight odontocete genera (Delphinus, Globicephala, Grampus, Kogia, Lagenorhynchus, Phocoena, Stenella, Tursiops). Flukes were imaged as 1 mm thickness cross-sections using X-ray computer-assisted tomography. Fluke shapes were characterized quantitatively by dimensions of the chord, maximum thickness, and position of maximum thickness from the leading edge. Sections were symmetrical about the chordline and had a rounded leading edge and highly tapered trailing edge. The thickness ratio (maximum thickness/chord) among species increased from insertion on the tailstock to a maximum at 20% of span and then decreasing steadily to the tip. Thickness ratio ranged from 0.139 to 0.232. These low values indicate reduced drag while moving at high speed. The position of maximum thickness from the leading edge remained constant over the fluke span at an average for all species of 0.285 chord. The displacement of the maximum thickness reduces the tendency of the flow to separate from the fluke surface, potentially affecting stall patterns. Similarly, the relatively large leading edge radius allows greater lift generation and delays stall. Computational analysis of fluke profiles at 50% of span showed that flukes were generally comparable or better for lift generation than engineered foils. Tursiops had the highest lift coefficients, which were superior to engineered foils by 12-19%. Variation in the structure of cetacean flukes reflects different hydrodynamic characteristics that could influence swimming performance.

  11. A Three-Dimensional Computational Human Head Model That Captures Live Human Brain Dynamics.

    PubMed

    Ganpule, Shailesh; Daphalapurkar, Nitin P; Ramesh, Kaliat T; Knutsen, Andrew K; Pham, Dzung L; Bayly, Philip V; Prince, Jerry L

    2017-04-10

    Diffuse axonal injury (DAI) is a debilitating consequence of traumatic brain injury (TBI) attributed to abnormal stretching of axons caused by blunt head trauma or acceleration of the head. We developed an anatomically accurate, subject-specific, three-dimensional (3D) computational model of the human brain, and used it to study the dynamic deformations in the substructures of the brain when the head is subjected to rotational accelerations. The computational head models use anatomy and morphology of the white matter fibers obtained using MRI. Subject-specific full-field shearing motions in live human brains obtained through a recently developed tagged MRI imaging technique are then used to validate the models by comparing the measured and predicted heterogeneous dynamic mechanical response of the brain. These results are used to elucidate the dynamics of local shearing deformations in the brain substructures caused by rotational acceleration of the head. Our work demonstrates that the rotational dynamics of the brain has a timescale of ∼100 ms as determined by the shearing wave speeds, and thus the injuries associated with rotational accelerations likely occur over these time scales. After subject-specific validation using the live human subject data, a representative subject-specific head model is used to simulate a real life scenario that resulted in a concussive injury. Results suggest that regions of the brain, in the form of a toroid, encompassing the white matter, the cortical gray matter, and outer parts of the limbic system have a higher susceptibility to injury under axial rotations of the head.

  12. Rigorous joining of advanced reduced-dimensional beam models to three-dimensional finite element models

    NASA Astrophysics Data System (ADS)

    Song, Huimin

    In the aerospace and automotive industries, many finite element analyses use lower-dimensional finite elements such as beams, plates and shells, to simplify the modeling. These simplified models can greatly reduce the computation time and cost; however, reduced-dimensional models may introduce inaccuracies, particularly near boundaries and near portions of the structure where reduced-dimensional models may not apply. Another factor in creation of such models is that beam-like structures frequently have complex geometry, boundaries and loading conditions, which may make them unsuitable for modeling with single type of element. The goal of this dissertation is to develop a method that can accurately and efficiently capture the response of a structure by rigorous combination of a reduced-dimensional beam finite element model with a model based on full two-dimensional (2D) or three-dimensional (3D) finite elements. The first chapter of the thesis gives the background of the present work and some related previous work. The second chapter is focused on formulating a system of equations that govern the joining of a 2D model with a beam model for planar deformation. The essential aspect of this formulation is to find the transformation matrices to achieve deflection and load continuity on the interface. Three approaches are provided to obtain the transformation matrices. An example based on joining a beam to a 2D finite element model is examined, and the accuracy of the analysis is studied by comparing joint results with the full 2D analysis. The third chapter is focused on formulating the system of equations for joining a beam to a 3D finite element model for static and free-vibration problems. The transition between the 3D elements and beam elements is achieved by use of the stress recovery technique of the variational-asymptotic method as implemented in VABS (the Variational Asymptotic Beam Section analysis). The formulations for an interface transformation matrix and

  13. Performance analysis of three dimensional integral equation computations on a massively parallel computer. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Logan, Terry G.

    1994-01-01

    The purpose of this study is to investigate the performance of the integral equation computations using numerical source field-panel method in a massively parallel processing (MPP) environment. A comparative study of computational performance of the MPP CM-5 computer and conventional Cray-YMP supercomputer for a three-dimensional flow problem is made. A serial FORTRAN code is converted into a parallel CM-FORTRAN code. Some performance results are obtained on CM-5 with 32, 62, 128 nodes along with those on Cray-YMP with a single processor. The comparison of the performance indicates that the parallel CM-FORTRAN code near or out-performs the equivalent serial FORTRAN code for some cases.

  14. Three-dimensional printing of X-ray computed tomography datasets with multiple materials using open-source data processing.

    PubMed

    Sander, Ian M; McGoldrick, Matthew T; Helms, My N; Betts, Aislinn; van Avermaete, Anthony; Owers, Elizabeth; Doney, Evan; Liepert, Taimi; Niebur, Glen; Liepert, Douglas; Leevy, W Matthew

    2017-02-23

    Advances in three-dimensional (3D) printing allow for digital files to be turned into a "printed" physical product. For example, complex anatomical models derived from clinical or pre-clinical X-ray computed tomography (CT) data of patients or research specimens can be constructed using various printable materials. Although 3D printing has the potential to advance learning, many academic programs have been slow to adopt its use in the classroom despite increased availability of the equipment and digital databases already established for educational use. Herein, a protocol is reported for the production of enlarged bone core and accurate representation of human sinus passages in a 3D printed format using entirely consumer-grade printers and a combination of free-software platforms. The comparative resolutions of three surface rendering programs were also determined using the sinuses, a human body, and a human wrist data files to compare the abilities of different software available for surface map generation of biomedical data. Data shows that 3D Slicer provided highest compatibility and surface resolution for anatomical 3D printing. Generated surface maps were then 3D printed via fused deposition modeling (FDM printing). In conclusion, a methodological approach that explains the production of anatomical models using entirely consumer-grade, fused deposition modeling machines, and a combination of free software platforms is presented in this report. The methods outlined will facilitate the incorporation of 3D printed anatomical models in the classroom. Anat Sci Educ. © 2017 American Association of Anatomists.

  15. A three-dimensional turbulent heat transfer analysis for advanced tubular rocket thrust chambers

    NASA Technical Reports Server (NTRS)

    Kacynski, Kenneth J.

    1990-01-01

    Heat transfer was analyzed in the throat region of a plug and spool rocket engine for both smooth and corrugated walls. A three-dimensional, Navier-Stokes code was used for the analysis. The turbulence model in the code was modified to handle turbulence suppression in the crevice region of the corrugated wall. The overall heat transfer at the throat for the corrugated wall was 34 percent higher than it was for the smooth wall for comparable rocket flow conditions.

  16. Application of computer generated color graphic techniques to the processing and display of three dimensional fluid dynamic data

    NASA Technical Reports Server (NTRS)

    Anderson, B. H.; Putt, C. W.; Giamati, C. C.

    1981-01-01

    Color coding techniques used in the processing of remote sensing imagery were adapted and applied to the fluid dynamics problems associated with turbofan mixer nozzles. The computer generated color graphics were found to be useful in reconstructing the measured flow field from low resolution experimental data to give more physical meaning to this information and in scanning and interpreting the large volume of computer generated data from the three dimensional viscous computer code used in the analysis.

  17. Computer Algorithms and Architectures for Three-Dimensional Eddy-Current Nondestructive Evaluation. Volume 3. Chapters 6-11

    DTIC Science & Technology

    1989-01-20

    mflC FILE. OOR SA/TR-2/89 A003: FINAL REPORT COMPUTER ALGORITHMS AND ARCHITECTURES FOR THREE-DIMENSIONAL EDDY-CURRENT NONDESTRUCTIVE EVALUATION CD...J., Ullman, J., The Design and Analysis of Computer Algorithms , Addison-Wesley Publishing Company, 1974. [A2] Anderson, B., Moore, J., Optimal...actual data. DC- 17 I I I I [All Aho, A., Hopcroft, J., Ullman, J., The Design and Analysis of Computer Algorithms , Addison-Wesley Publishing Company

  18. Development of a percentile based three-dimensional model of the buttocks in computer system

    NASA Astrophysics Data System (ADS)

    Wang, Lijing; He, Xueli; Li, Hongpeng

    2016-05-01

    There are diverse products related to human buttocks, which need to be designed, manufactured and evaluated with 3D buttock model. The 3D buttock model used in present research field is just simple approximate model similar to human buttocks. The 3D buttock percentile model is highly desired in the ergonomics design and evaluation for these products. So far, there is no research on the percentile sizing system of human 3D buttock model. So the purpose of this paper is to develop a new method for building three-dimensional buttock percentile model in computer system. After scanning the 3D shape of buttocks, the cloud data of 3D points is imported into the reverse engineering software (Geomagic) for the reconstructing of the buttock surface model. Five characteristic dimensions of the buttock are measured through mark-points after models being imported into engineering software CATIA. A series of space points are obtained by the intersecting of the cutting slices and 3D buttock surface model, and then are ordered based on the sequence number of the horizontal and vertical slices. The 1st, 5th, 50th, 95th, 99th percentile values of the five dimensions and the spatial coordinate values of the space points are obtained, and used to reconstruct percentile buttock models. This research proposes a establishing method of percentile sizing system of buttock 3D model based on the percentile values of the ischial tuberosities diameter, the distances from margin to ischial tuberosity and the space coordinates value of coordinate points, for establishing the Nth percentile 3D buttock model and every special buttock types model. The proposed method also serves as a useful guidance for the other 3D percentile models establishment for other part in human body with characteristic points.

  19. Prenatal diagnosis of sirenomelia in the late second trimester with three-dimensional helical computed tomography.

    PubMed

    Ono, Tetsuo; Katsura, Daisuke; Tsuji, Shunichiro; Yomo, Hiroko; Ishiko, Akiko; Inoue, Takashi; Kita, Nobuyuki; Takahashi, Kentaro; Murakami, Takashi

    2011-01-01

    Sirenomelia is a rare congenital syndrome that is characterized by the anomalous development of the caudal region of the body. The anomalies include bilateral renal agenesis or dysgenesis and the absence of the sacrum and other vertebral defects. Sirenomelia is also known as "mermaid syndrome," because of the one lower extremity. It is usually associated with severe oligohydramnios, and its prognosis is very poor due to pulmonary hypoplasia that is caused by severe oligohydramnios. The patient referred to our hospital at the gestational age of 27 weeks with fetal growth restriction and oligohydramnios. The estimated fetal body weight was 970 g (-4.9 S.D.). We could identify only one-side extremities, and could not identify kidneys by ultrasound examination. Because a single lower extremity and severe oligohydramnios are characteristics of the sirenomelia, we suspected sirenomelia. However, it could not be confirmed by ultrasound examination because of oligohydramnios. Therefore, we performed three-dimensional helical computed tomography (3D-CT), which is more accurate than ultrasound examinations for prenatal diagnosis of skeletal abnormalities. 3D-CT revealed an only one lower extremity. At 36 weeks and 5 days of gestation, the woman went into spontaneous labor and delivered an infant weighing 870 g. The infant has a single upper extremity and a single lower extremity. We provided supportive care for the neonate, who however died 1 hour 36 minutes after birth from severe respiratory distress. In summary, we report the correct diagnosis of sirenomelia with 3D-CT in the late second trimester.

  20. The Availability of Radiological Measurement of Femoral Anteversion Angle: Three-Dimensional Computed Tomography Reconstruction

    PubMed Central

    Byun, Ha Young; Shin, Heesuk; Lee, Eun Shin; Kong, Min Sik; Lee, Seung Hun

    2016-01-01

    Objective To assess the intra-rater and inter-rater reliability for measuring femoral anteversion angle (FAA) by a radiographic method using three-dimensional computed tomography reconstruction (3D-CT). Methods The study included 82 children who presented with intoeing gait. 3D-CT data taken between 2006 and 2014 were retrospectively reviewed. FAA was measured by 3D-CT. FAA is defined as the angle between the long axis of the femur neck and condylar axis of the distal femur. FAA measurement was performed twice at both lower extremities by each rater. The intra-rater and inter-rater reliability were calculated by intraclass correlation coefficient (ICC). Results One hundred and sixty-four lower limbs of 82 children (31 boys and 51 girls, 6.3±3.2 years old) were included. The ICCs of intra-rater measurement for the angle of femoral neck axis (NA) were 0.89 for rater A and 0.96 for rater B, and those of condylar axis (CA) were 0.99 for rater A and 0.99 for rater B, respectively. The ICC of inter-rater measurement for the angle of NA was 0.89 and that of CA was 0.92. By each rater, the ICCs of the intrarater measurement for FAA were 0.97 for rater A and 0.95 for rater B, respectively and the ICC of the inter-rater measurement for FAA was 0.89. Conclusion The 3D-CT measures for FAA are reliable within individual raters and between different raters. The 3D-CT measures of FAA can be a useful method for accurate diagnosis and follow-up of femoral anteversion. PMID:27152273

  1. High-immersion three-dimensional display of the numerical computer model

    NASA Astrophysics Data System (ADS)

    Xing, Shujun; Yu, Xunbo; Zhao, Tianqi; Cai, Yuanfa; Chen, Duo; Chen, Zhidong; Sang, Xinzhu

    2013-08-01

    High-immersion three-dimensional (3D) displays making them valuable tools for many applications, such as designing and constructing desired building houses, industrial architecture design, aeronautics, scientific research, entertainment, media advertisement, military areas and so on. However, most technologies provide 3D display in the front of screens which are in parallel with the walls, and the sense of immersion is decreased. To get the right multi-view stereo ground image, cameras' photosensitive surface should be parallax to the public focus plane and the cameras' optical axes should be offset to the center of public focus plane both atvertical direction and horizontal direction. It is very common to use virtual cameras, which is an ideal pinhole camera to display 3D model in computer system. We can use virtual cameras to simulate the shooting method of multi-view ground based stereo image. Here, two virtual shooting methods for ground based high-immersion 3D display are presented. The position of virtual camera is determined by the people's eye position in the real world. When the observer stand in the circumcircle of 3D ground display, offset perspective projection virtual cameras is used. If the observer stands out the circumcircle of 3D ground display, offset perspective projection virtual cameras and the orthogonal projection virtual cameras are adopted. In this paper, we mainly discussed the parameter setting of virtual cameras. The Near Clip Plane parameter setting is the main point in the first method, while the rotation angle of virtual cameras is the main point in the second method. In order to validate the results, we use the D3D and OpenGL to render scenes of different viewpoints and generate a stereoscopic image. A realistic visualization system for 3D models is constructed and demonstrated for viewing horizontally, which provides high-immersion 3D visualization. The displayed 3D scenes are compared with the real objects in the real world.

  2. The Impact of Three-Dimensional Computational Modeling on Student Understanding of Astronomy Concepts: A Qualitative Analysis. Research Report

    ERIC Educational Resources Information Center

    Hansen, John A.; Barnett, Michael; MaKinster, James G.; Keating, Thomas

    2004-01-01

    In this study, we explore an alternate mode for teaching and learning the dynamic, three-dimensional (3D) relationships that are central to understanding astronomical concepts. To this end, we implemented an innovative undergraduate course in which we used inexpensive computer modeling tools. As the second of a two-paper series, this report…

  3. The Virtual Solar System Project: Developing Conceptual Understanding of Astronomical Concepts through Building Three-Dimensional Computational Models.

    ERIC Educational Resources Information Center

    Keating, Thomas; Barnett, Michael; Barab, Sasha A.; Hay, Kenneth E.

    2002-01-01

    Describes the Virtual Solar System (VSS) course which is one of the first attempts to integrate three-dimensional (3-D) computer modeling as a central component of introductory undergraduate education. Assesses changes in student understanding of astronomy concepts as a result of participating in an experimental introductory astronomy course in…

  4. Three-Dimensional Wiring for Extensible Quantum Computing: The Quantum Socket

    NASA Astrophysics Data System (ADS)

    Béjanin, J. H.; McConkey, T. G.; Rinehart, J. R.; Earnest, C. T.; McRae, C. R. H.; Shiri, D.; Bateman, J. D.; Rohanizadegan, Y.; Penava, B.; Breul, P.; Royak, S.; Zapatka, M.; Fowler, A. G.; Mariantoni, M.

    2016-10-01

    Quantum computing architectures are on the verge of scalability, a key requirement for the implementation of a universal quantum computer. The next stage in this quest is the realization of quantum error-correction codes, which will mitigate the impact of faulty quantum information on a quantum computer. Architectures with ten or more quantum bits (qubits) have been realized using trapped ions and superconducting circuits. While these implementations are potentially scalable, true scalability will require systems engineering to combine quantum and classical hardware. One technology demanding imminent efforts is the realization of a suitable wiring method for the control and the measurement of a large number of qubits. In this work, we introduce an interconnect solution for solid-state qubits: the quantum socket. The quantum socket fully exploits the third dimension to connect classical electronics to qubits with higher density and better performance than two-dimensional methods based on wire bonding. The quantum socket is based on spring-mounted microwires—the three-dimensional wires—that push directly on a microfabricated chip, making electrical contact. A small wire cross section (approximately 1 mm), nearly nonmagnetic components, and functionality at low temperatures make the quantum socket ideal for operating solid-state qubits. The wires have a coaxial geometry and operate over a frequency range from dc to 8 GHz, with a contact resistance of approximately 150 m Ω , an impedance mismatch of approximately 10 Ω , and minimal cross talk. As a proof of principle, we fabricate and use a quantum socket to measure high-quality superconducting resonators at a temperature of approximately 10 mK. Quantum error-correction codes such as the surface code will largely benefit from the quantum socket, which will make it possible to address qubits located on a two-dimensional lattice. The present implementation of the socket could be readily extended to accommodate a

  5. Volumetric Analysis of Alveolar Bone Defect Using Three-Dimensional-Printed Models Versus Computer-Aided Engineering.

    PubMed

    Du, Fengzhou; Li, Binghang; Yin, Ningbei; Cao, Yilin; Wang, Yongqian

    2017-03-01

    Knowing the volume of a graft is essential in repairing alveolar bone defects. This study investigates the 2 advanced preoperative volume measurement methods: three-dimensional (3D) printing and computer-aided engineering (CAE). Ten unilateral alveolar cleft patients were enrolled in this study. Their computed tomographic data were sent to 3D printing and CAE software. A simulated graft was used on the 3D-printed model, and the graft volume was measured by water displacement. The volume calculated by CAE software used mirror-reverses technique. The authors compared the actual volumes of the simulated grafts with the CAE software-derived volumes. The average volume of the simulated bone grafts by 3D-printed models was 1.52 mL, higher than the mean volume of 1.47 calculated by CAE software. The difference between the 2 volumes was from -0.18 to 0.42 mL. The paired Student t test showed no statistically significant difference between the volumes derived from the 2 methods. This study demonstrated that the mirror-reversed technique by CAE software is as accurate as the simulated operation on 3D-printed models in unilateral alveolar cleft patients. These findings further validate the use of 3D printing and CAE technique in alveolar defect repairing.

  6. High-speed, sparse-sampling three-dimensional photoacoustic computed tomography in vivo based on principal component analysis

    NASA Astrophysics Data System (ADS)

    Meng, Jing; Jiang, Zibo; Wang, Lihong V.; Park, Jongin; Kim, Chulhong; Sun, Mingjian; Zhang, Yuanke; Song, Liang

    2016-07-01

    Photoacoustic computed tomography (PACT) has emerged as a unique and promising technology for multiscale biomedical imaging. To fully realize its potential for various preclinical and clinical applications, development of systems with high imaging speed, reasonable cost, and manageable data flow are needed. Sparse-sampling PACT with advanced reconstruction algorithms, such as compressed-sensing reconstruction, has shown potential as a solution to this challenge. However, most such algorithms require iterative reconstruction and thus intense computation, which may lead to excessively long image reconstruction times. Here, we developed a principal component analysis (PCA)-based PACT (PCA-PACT) that can rapidly reconstruct high-quality, three-dimensional (3-D) PACT images with sparsely sampled data without requiring an iterative process. In vivo images of the vasculature of a human hand were obtained, thus validating the PCA-PACT method. The results showed that, compared with the back-projection (BP) method, PCA-PACT required ˜50% fewer measurements and ˜40% less time for image reconstruction, and the imaging quality was almost the same as that for BP with full sampling. In addition, compared with compressed sensing-based PACT, PCA-PACT had approximately sevenfold faster imaging speed with higher imaging accuracy. This work suggests a promising approach for low-cost, 3-D, rapid PACT for various biomedical applications.

  7. Comparative study of cranial anthropometric measurement by traditional calipers to computed tomography and three-dimensional photogrammetry.

    PubMed

    Mendonca, Derick A; Naidoo, Sybill D; Skolnick, Gary; Skladman, Rachel; Woo, Albert S

    2013-07-01

    Craniofacial anthropometry by direct caliper measurements is a common method of quantifying the morphology of the cranial vault. New digital imaging modalities including computed tomography and three-dimensional photogrammetry are similarly being used to obtain craniofacial surface measurements. This study sought to compare the accuracy of anthropometric measurements obtained by calipers versus 2 methods of digital imaging.Standard anterior-posterior, biparietal, and cranial index measurements were directly obtained on 19 participants with an age range of 1 to 20 months. Computed tomographic scans and three-dimensional photographs were both obtained on each child within 2 weeks of the clinical examination. Two analysts measured the anterior-posterior and biparietal distances on the digital images. Measures of reliability and bias between the modalities were calculated and compared.Caliper measurements were found to underestimate the anterior-posterior and biparietal distances as compared with those of the computed tomography and the three-dimensional photogrammetry (P < 0.001). Cranial index measurements between the computed tomography and the calipers differed by up to 6%. The difference between the 2 modalities was statistically significant (P = 0.021). The biparietal and cranial index results were similar between the digital modalities, but the anterior-posterior measurement was greater with the three-dimensional photogrammetry (P = 0.002). The coefficients of variation for repeated measures based on the computed tomography and the three-dimensional photogrammetry were 0.008 and 0.007, respectively.In conclusion, measurements based on digital modalities are generally reliable and interchangeable. Caliper measurements lead to underestimation of anterior-posterior and biparietal values compared with digital imaging.

  8. Locomotion in ornithischian dinosaurs: an assessment using three-dimensional computational modelling.

    PubMed

    Maidment, Susannah C R; Bates, Karl T; Falkingham, Peter L; VanBuren, Collin; Arbour, Victoria; Barrett, Paul M

    2014-08-01

    Ornithischian dinosaurs were primitively bipedal with forelimbs modified for grasping, but quadrupedalism evolved in the clade on at least three occasions independently. Outside of Ornithischia, quadrupedality from bipedal ancestors has only evolved on two other occasions, making this one of the rarest locomotory transitions in tetrapod evolutionary history. The osteological and myological changes associated with these transitions have only recently been documented, and the biomechanical consequences of these changes remain to be examined. Here, we review previous approaches to understanding locomotion in extinct animals, which can be broadly split into form-function approaches using analogy based on extant animals, limb-bone scaling, and computational approaches. We then carry out the first systematic attempt to quantify changes in locomotor muscle function in bipedal and quadrupedal ornithischian dinosaurs. Using three-dimensional computational modelling of the major pelvic locomotor muscle moment arms, we examine similarities and differences among individual taxa, between quadrupedal and bipedal taxa, and among taxa representing the three major ornithischian lineages (Thyreophora, Ornithopoda, Marginocephalia). Our results suggest that the ceratopsid Chasmosaurus and the ornithopod Hypsilophodon have relatively low moment arms for most muscles and most functions, perhaps suggesting poor locomotor performance in these taxa. Quadrupeds have higher abductor moment arms than bipeds, which we suggest is due to the overall wider bodies of the quadrupeds modelled. A peak in extensor moment arms at more extended hip angles and lower medial rotator moment arms in quadrupeds than in bipeds may be due to a more columnar hindlimb and loss of medial rotation as a form of lateral limb support in quadrupeds. We are not able to identify trends in moment arm evolution across Ornithischia as a whole, suggesting that the bipedal ancestry of ornithischians did not constrain the

  9. Parallel Computation and Visualization of Three-dimensional, Time-dependent, Thermal Convective Flows

    NASA Technical Reports Server (NTRS)

    Wang, P.; Li, P.

    1998-01-01

    A high-resolution numerical study on parallel systems is reported on three-dimensional, time-dependent, thermal convective flows. A parallel implentation on the finite volume method with a multigrid scheme is discussed, and a parallel visualization systemm is developed on distributed systems for visualizing the flow.

  10. A Three-Dimensional Turbulent Heat Transfer Analysis for Advanced Tubular Rocket Thrust Chambers

    NASA Technical Reports Server (NTRS)

    Kacynski, Kenneth J.

    1990-01-01

    Heat transfer was analyzed in the throat region of a plug and spool rocket engine for both smooth and corrugated walls. A three-dimensional, Navier-Strokes code was used for the analysis. The turbulence model in the code was modified to handle turbulence suppression in the crevice region of the corrugated wall. Circumferential variations in the wall heat transfer was predicted for the corrugated wall. The overall heat transfer at the throat of the corrugated wall was 34 percent higher than it was for the smooth wall for comparable rocket flow conditions.

  11. Three dimensional identification card and applications

    NASA Astrophysics Data System (ADS)

    Zhou, Changhe; Wang, Shaoqing; Li, Chao; Li, Hao; Liu, Zhao

    2016-10-01

    Three dimensional Identification Card, with its three-dimensional personal image displayed and stored for personal identification, is supposed be the advanced version of the present two-dimensional identification card in the future [1]. Three dimensional Identification Card means that there are three-dimensional optical techniques are used, the personal image on ID card is displayed to be three-dimensional, so we can see three dimensional personal face. The ID card also stores the three-dimensional face information in its inside electronics chip, which might be recorded by using two-channel cameras, and it can be displayed in computer as three-dimensional images for personal identification. Three-dimensional ID card might be one interesting direction to update the present two-dimensional card in the future. Three-dimension ID card might be widely used in airport custom, entrance of hotel, school, university, as passport for on-line banking, registration of on-line game, etc...

  12. A New Method for Computing Three-Dimensional Capture Fraction in Heterogeneous Regional Systems using the MODFLOW Adjoint Code

    NASA Astrophysics Data System (ADS)

    Clemo, T. M.; Ramarao, B.; Kelly, V. A.; Lavenue, M.

    2011-12-01

    Capture is a measure of the impact of groundwater pumping upon groundwater and surface water systems. The computation of capture through analytical or numerical methods has been the subject of articles in the literature for several decades (Bredehoeft et al., 1982). Most recently Leake et al. (2010) described a systematic way to produce capture maps in three-dimensional systems using a numerical perturbation approach in which capture from streams was computed using unit rate pumping at many locations within a MODFLOW model. The Leake et al. (2010) method advances the current state of computing capture. A limitation stems from the computational demand required by the perturbation approach wherein days or weeks of computational time might be required to obtain a robust measure of capture. In this paper, we present an efficient method to compute capture in three-dimensional systems based upon adjoint states. The efficiency of the adjoint method will enable uncertainty analysis to be conducted on capture calculations. The USGS and INTERA have collaborated to extend the MODFLOW Adjoint code (Clemo, 2007) to include stream-aquifer interaction and have applied it to one of the examples used in Leake et al. (2010), the San Pedro Basin MODFLOW model. With five layers and 140,800 grid blocks per layer, the San Pedro Basin model, provided an ideal example data set to compare the capture computed from the perturbation and the adjoint methods. The capture fraction map produced from the perturbation method for the San Pedro Basin model required significant computational time to compute and therefore the locations for the pumping wells were limited to 1530 locations in layer 4. The 1530 direct simulations of capture require approximately 76 CPU hours. Had capture been simulated in each grid block in each layer, as is done in the adjoint method, the CPU time would have been on the order of 4 years. The MODFLOW-Adjoint produced the capture fraction map of the San Pedro Basin model

  13. Dedicated Three-dimensional Breast Computed Tomography: Lesion Characteristic Perception by Radiologists

    PubMed Central

    Kuzmiak, Cherie Marie; Cole, Elodia B; Zeng, Donglin; Tuttle, Laura A; Steed, Doreen; Pisano, Etta D

    2016-01-01

    Objectives: To assess radiologist confidence in the characterization of suspicious breast lesions with a dedicated three-dimensional breast computed tomography (DBCT) system in comparison to diagnostic two-dimensional digital mammography (dxDM). Materials and Methods: Twenty women were recruited who were to undergo a breast biopsy for a Breast Imaging-Reporting and Data System (BI-RADS) 4 or 5 lesion evaluated with dxDM in this Institutional Review Board-approved study. The enrolled subjects underwent imaging of the breast(s) of concern using DBCT. Seven radiologists reviewed the cases. Each reader compared DBCT to the dxDM and was asked to specify the lesion type and BI-RADS score for each lesion and modality. They also compared lesion characteristics: Shape for masses or morphology for calcifications; and margins for masses or distribution for calcifications between the modalities using confidence scores (0–100). Results: Twenty-four biopsied lesions were included in this study: 17 (70.8%) masses and 7 (29.2%) calcifications. Eight (33.3%) lesions were malignant, and 16 (66.7%) were benign. Across all lesions, there was no significant difference in the margin/distribution (Δ = −0.99, P = 0.84) and shape/morphology (Δ = −0.10, P = 0.98) visualization confidence scores of DBCT in relation to dxDM. However, analysis by lesion type showed a statistically significant increase in reader shape (Δ =11.34, P = 0.013) and margin (Δ =9.93, P = 0.023) visualization confidence with DBCT versus dxDM for masses and significant decrease in reader morphology (Δ = −29.95, P = 0.001) and distribution (Δ = −28.62, P = 0.002) visualization confidence for calcifications. Conclusion: Reader confidence in the characterization of suspicious masses is significantly improved with DBCT, but reduced for calcifications. Further study is needed to determine whether this technology can be used for breast cancer screening. PMID:27195180

  14. Aerodynamic Analyses Requiring Advanced Computers, part 2

    NASA Technical Reports Server (NTRS)

    1975-01-01

    Papers given at the conference present the results of theoretical research on aerodynamic flow problems requiring the use of advanced computers. Topics discussed include two-dimensional configurations, three-dimensional configurations, transonic aircraft, and the space shuttle.

  15. A Computer Program for Calculating Three-Dimensional Compressible Laminar and Turbulent Boundary Layers on Arbitrary Wings

    NASA Technical Reports Server (NTRS)

    Cebeci, T.; Kaups, K.; Ramsey, J. A.

    1977-01-01

    A computer program for calculating three dimensional compressible laminar and turbulent boundary layers on arbitrary wings is described and presented. The computer program consists of three separate programs, namely, a geometry program to represent the wing analytically, a velocity program to compute the external velocity components from a given experimental pressure distribution and a finite difference boundary layer method to solve the governing equations for compressible flows. To illustrate the usage of the computer program, three different test cases are presented and the preparation of the input data as well as the computed output data is discussed in some detail.

  16. The development of an explicit thermochemical nonequilibrium algorithm and its application to compute three dimensional AFE flowfields

    NASA Technical Reports Server (NTRS)

    Palmer, Grant

    1989-01-01

    This study presents a three-dimensional explicit, finite-difference, shock-capturing numerical algorithm applied to viscous hypersonic flows in thermochemical nonequilibrium. The algorithm employs a two-temperature physical model. Equations governing the finite-rate chemical reactions are fully-coupled to the gas dynamic equations using a novel coupling technique. The new coupling method maintains stability in the explicit, finite-rate formulation while allowing relatively large global time steps. The code uses flux-vector accuracy. Comparisons with experimental data and other numerical computations verify the accuracy of the present method. The code is used to compute the three-dimensional flowfield over the Aeroassist Flight Experiment (AFE) vehicle at one of its trajectory points.

  17. GRID3C: Computer program for generation of C type multilevel, three dimensional and boundary conforming periodic grids

    NASA Technical Reports Server (NTRS)

    Dulikravich, D. S.

    1982-01-01

    A fast computer program, GRID3C, was developed for accurately generating periodic, boundary conforming, three dimensional, consecutively refined computational grids applicable to realistic axial turbomachinery geometries. The method is based on using two functions to generate two dimensional grids on a number of coaxial axisymmetric surfaces positioned between the centerbody and the outer radial boundary. These boundary fitted grids are of the C type and are characterized by quasi-orthogonality and geometric periodicity. The built in nonorthogonal coordinate stretchings and shearings cause the grid clustering in the regions of interest. The stretching parameters are part of the input to GRID3C. In its present version GRID3C can generate and store a maximum of four consecutively refined three dimensional grids. The output grid coordinates can be calculated either in the Cartesian or in the cylindrical coordinate system.

  18. Quadcopter control in three-dimensional space using a noninvasive motor imagery based brain-computer interface

    PubMed Central

    LaFleur, Karl; Cassady, Kaitlin; Doud, Alexander; Shades, Kaleb; Rogin, Eitan; He, Bin

    2013-01-01

    Objective At the balanced intersection of human and machine adaptation is found the optimally functioning brain-computer interface (BCI). In this study, we report a novel experiment of BCI controlling a robotic quadcopter in three-dimensional physical space using noninvasive scalp EEG in human subjects. We then quantify the performance of this system using metrics suitable for asynchronous BCI. Lastly, we examine the impact that operation of a real world device has on subjects’ control with comparison to a two-dimensional virtual cursor task. Approach Five human subjects were trained to modulate their sensorimotor rhythms to control an AR Drone navigating a three-dimensional physical space. Visual feedback was provided via a forward facing camera on the hull of the drone. Individual subjects were able to accurately acquire up to 90.5% of all valid targets presented while travelling at an average straight-line speed of 0.69 m/s. Significance Freely exploring and interacting with the world around us is a crucial element of autonomy that is lost in the context of neurodegenerative disease. Brain-computer interfaces are systems that aim to restore or enhance a user’s ability to interact with the environment via a computer and through the use of only thought. We demonstrate for the first time the ability to control a flying robot in the three-dimensional physical space using noninvasive scalp recorded EEG in humans. Our work indicates the potential of noninvasive EEG based BCI systems to accomplish complex control in three-dimensional physical space. The present study may serve as a framework for the investigation of multidimensional non-invasive brain-computer interface control in a physical environment using telepresence robotics. PMID:23735712

  19. Users' manual for computer program for three-dimensional analysis of coupler-cavity traveling wave tubes

    NASA Technical Reports Server (NTRS)

    Omalley, T. A.

    1984-01-01

    The use of the coupled cavity traveling wave tube for space communications has led to an increased interest in improving the efficiency of the basic interaction process in these devices through velocity resynchronization and other methods. A flexible, three dimensional, axially symmetric, large signal computer program was developed for use on the IBM 370 time sharing system. A users' manual for this program is included.

  20. Transient Three-Dimensional Heat Conduction Computations Using Brian’s Technique

    DTIC Science & Technology

    1988-09-01

    tilk ."J k ) +VU (T..2 - ) V(T. *)+V(.. TJ +w2 I~ +w U5w6 +x 2 (T. T2 ) +x3 (T~ -T 3 )+X(T’ -)+YE V6.J6-tk 20. Perimeter 6 -FRTn+l (1 +2 FMR )T n+1-FoR...7, pp. 367-370, September 1961. 4. Clover, R. M., and Wassel, A. T., "Three-Dimensional Transient Heat Conduction in a Multilayer Medium," Journal of

  1. Three-dimensional visualization of cardiac single-photon-emission computed-tomography studies

    NASA Astrophysics Data System (ADS)

    Cooke, C. D.; Garcia, Ernest V.; Folks, Russell D.; Peifer, John W.

    1992-09-01

    We have previously reported on a method for visualizing cardiovascular nuclear medicine tomographic perfusion studies which included: long and short axis slices, two-dimensional (2- D) polar maps, three-dimensional (3-D) surface models, and four-dimensional surface models. We have since validated the 3-D surface model in a prospective patient population, added the ability to generate 3-D models from any polar map, and added a panoramic display that allows two 3-D models to be compared side-by-side. This paper describes the methodologies involved in these enhancements.

  2. Comparisons of computed and measured three-dimensional velocity fields in a motored two-stroke engine

    SciTech Connect

    Amsden, A.A.; O'Rourke, P.J.; Butler, T.D. ); Meintjes, K.; Fansler, T.D. )

    1991-01-01

    Computer simulations are compared with measurements of the three-dimensional, unsteady scavenging flows of a motored two-stroke engine. Laser Doppler velocimetry measurements were made on a modified Suzuki DT-85 ported engine. Calculations were performed using KIVA-3, a computer program that efficiently solves the intake and exhaust port flows along with those in the cylinder. Measured and computed cylinder pressures and velocities are compared. Pressures agree well over the cycle as do the velocities at the intake ports. In-cylinder velocities differ in detail, but the tumbling motion in the cylinder is well replicated in vertical plane passing through the cylinder axis. 20 refs., 7 figs., 3 tabs.

  3. User's manual for master: Modeling of aerodynamic surfaces by 3-dimensional explicit representation. [input to three dimensional computational fluid dynamics

    NASA Technical Reports Server (NTRS)

    Gibson, S. G.

    1983-01-01

    A system of computer programs was developed to model general three dimensional surfaces. Surfaces are modeled as sets of parametric bicubic patches. There are also capabilities to transform coordinates, to compute mesh/surface intersection normals, and to format input data for a transonic potential flow analysis. A graphical display of surface models and intersection normals is available. There are additional capabilities to regulate point spacing on input curves and to compute surface/surface intersection curves. Input and output data formats are described; detailed suggestions are given for user input. Instructions for execution are given, and examples are shown.

  4. Hierarchically designed three-dimensional macro/mesoporous carbon frameworks for advanced electrochemical capacitance storage.

    PubMed

    Yang, Yanbing; Li, Peixu; Wu, Shiting; Li, Xinyang; Shi, Enzheng; Shen, Qicang; Wu, Dehai; Xu, Wenjing; Cao, Anyuan; Yuan, Quan

    2015-04-13

    Mesoporous carbon (m-C) has potential applications as porous electrodes for electrochemical energy storage, but its applications have been severely limited by the inherent fragility and low electrical conductivity. A rational strategy is presented to construct m-C into hierarchical porous structures with high flexibility by using a carbon nanotube (CNT) sponge as a three-dimensional template, and grafting Pt nanoparticles at the m-C surface. This method involves several controllable steps including solution deposition of a mesoporous silica (m-SiO2 ) layer onto CNTs, chemical vapor deposition of acetylene, and etching of m-SiO2 , resulting in a CNT@m-C core-shell or a CNT@m-C@Pt core-shell hybrid structure after Pt adsorption. The underlying CNT network provides a robust yet flexible support and a high electrical conductivity, whereas the m-C provides large surface area, and the Pt nanoparticles improves interfacial electron and ion diffusion. Consequently, specific capacitances of 203 and 311 F g(-1) have been achieved in these CNT@m-C and CNT@m-C@Pt sponges as supercapacitor electrodes, respectively, which can retain 96 % of original capacitance under large degree compression.

  5. Advanced three-dimensional electron microscopy techniques in the quest for better structural and functional materials

    PubMed Central

    Schryvers, D; Cao, S; Tirry, W; Idrissi, H; Van Aert, S

    2013-01-01

    After a short review of electron tomography techniques for materials science, this overview will cover some recent results on different shape memory and nanostructured metallic systems obtained by various three-dimensional (3D) electron imaging techniques. In binary Ni–Ti, the 3D morphology and distribution of Ni4Ti3 precipitates are investigated by using FIB/SEM slice-and-view yielding 3D data stacks. Different quantification techniques will be presented including the principal ellipsoid for a given precipitate, shape classification following a Zingg scheme, particle distribution function, distance transform and water penetration. The latter is a novel approach to quantifying the expected matrix transformation in between the precipitates. The different samples investigated include a single crystal annealed with and without compression yielding layered and autocatalytic precipitation, respectively, and a polycrystal revealing different densities and sizes of the precipitates resulting in a multistage transformation process. Electron tomography was used to understand the interaction between focused ion beam-induced Frank loops and long dislocation structures in nanobeams of Al exhibiting special mechanical behaviour measured by on-chip deposition. Atomic resolution electron tomography is demonstrated on Ag nanoparticles in an Al matrix. PMID:27877554

  6. Advanced three-dimensional thermal modeling of a baseline spent fuel repository

    SciTech Connect

    Altenbach, T.J.; Lowry, W.E.

    1980-04-29

    A three-dimensional thermal analysis using finite difference techniques was performed to determine the near-field response of a baseline spent fuel repository in a deep geologic salt medium. A baseline design incorporates previous thermal modeling experience and OWI recommendations for areal thermal loading in specifying the waste form properties, package details, and emplacement configuration. The base case in this thermal analysis considers one 10-year old PWR spent fuel assembly emplaced to yield a 36 kW/acre (8.9 W/m/sup 2/) loading. A unit cell model in an infinite array is used to simplify the problem and provide upper-bound temperatures. Boundary conditions are imposed which allow simulations to 1000 years. Variations studied include a comparison of ventilated and unventilated storage room conditions, emplacement packages with and without air gaps surrounding the canister, and room cool-down scenarios with ventilation following an unventilated state for retrieval purposes. It was found that at this low-power level, ventilating the emplacement room has an immediate cooling influence on the canister and effectively maintains the emplacement room floor near the temperature of the ventilating air.

  7. Computational modeling of phonatory dynamics in a tubular three-dimensional model of the human larynx

    PubMed Central

    Xue, Q.; Mittal, R.; Zheng, X.; Bielamowicz, S.

    2012-01-01

    Simulation of the phonatory flow-structure interaction has been conducted in a three-dimensional, tubular shaped laryngeal model that has been designed with a high level of realism with respect to the human laryngeal anatomy. A non-linear spring-based contact force model is also implemented for the purpose of representing contact in more general conditions, especially those associated with three-dimensional modeling of phonation in the presence of vocal fold pathologies. The model is used to study the effects of a moderate (20%) vocal-fold tension imbalance on the phonatory dynamics. The characteristic features of phonation for normal as well as tension-imbalanced vocal folds, such as glottal waveform, glottal jet evolution, mucosal wave-type vocal-fold motion, modal entrainment, and asymmetric glottal jet deflection have been discussed in detail and compared to established data. It is found that while a moderate level of tension asymmetry does not change the vibratory dynamics significantly, it can potentially lead to measurable deterioration in voice quality. PMID:22978889

  8. SEISMIC SIMULATIONS USING PARALLEL COMPUTING AND THREE-DIMENSIONAL EARTH MODELS TO IMPROVE NUCLEAR EXPLOSION PHENOMENOLOGY AND MONITORING

    SciTech Connect

    Rodgers, A; Matzel, E; Pasyanos, M; Petersson, A; Sjogreen, B; Bono, C; Vorobiev, O; Antoun, T; Walter, W; Myers, S; Lomov, I

    2008-07-07

    The development of accurate numerical methods to simulate wave propagation in three-dimensional (3D) earth models and advances in computational power offer exciting possibilities for modeling the motions excited by underground nuclear explosions. This presentation will describe recent work to use new numerical techniques and parallel computing to model earthquakes and underground explosions to improve understanding of the wave excitation at the source and path-propagation effects. Firstly, we are using the spectral element method (SEM, SPECFEM3D code of Komatitsch and Tromp, 2002) to model earthquakes and explosions at regional distances using available 3D models. SPECFEM3D simulates anelastic wave propagation in fully 3D earth models in spherical geometry with the ability to account for free surface topography, anisotropy, ellipticity, rotation and gravity. Results show in many cases that 3D models are able to reproduce features of the observed seismograms that arise from path-propagation effects (e.g. enhanced surface wave dispersion, refraction, amplitude variations from focusing and defocusing, tangential component energy from isotropic sources). We are currently investigating the ability of different 3D models to predict path-specific seismograms as a function of frequency. A number of models developed using a variety of methodologies are available for testing. These include the WENA/Unified model of Eurasia (e.g. Pasyanos et al 2004), the global CUB 2.0 model (Shapiro and Ritzwoller, 2002), the partitioned waveform model for the Mediterranean (van der Lee et al., 2007) and stochastic models of the Yellow Sea Korean Peninsula region (Pasyanos et al., 2006). Secondly, we are extending our Cartesian anelastic finite difference code (WPP of Nilsson et al., 2007) to model the effects of free-surface topography. WPP models anelastic wave propagation in fully 3D earth models using mesh refinement to increase computational speed and improve memory efficiency. Thirdly

  9. Computer Simulation Study of Human Locomotion with a Three-Dimensional Entire-Body Neuro-Musculo-Skeletal Model

    NASA Astrophysics Data System (ADS)

    Hase, Kazunori; Yokoi, Takashi

    In the present study, the computer simulation technique to autonomously generate running motion from walking was developed using a three-dimensional entire-body neuro-musculo-skeletal model. When maximizing locomotive speed was employed as the evaluative criterion, the initial walking pattern could not transition to a valid running motion. When minimizing the period of foot-ground contact was added to this evaluative criterion, the simulation model autonomously produced appropriate three-dimensional running. Changes in the neuronal system showed the fatigue coefficient of the neural oscillators to reduce as locomotion patterns transitioned from walking to running. Then, when the running speed increased, the amplitude of the non-specific stimulus from the higher center increased. These two changes indicate mean that the improvement in responsiveness of the neuronal system is important for the transition process from walking to running, and that the comprehensive activation level of the neuronal system is essential in the process of increasing running speed.

  10. Three-dimensional dynamics of scientific balloon systems in response to sudden gust loadings. [including a computer program user manual

    NASA Technical Reports Server (NTRS)

    Dorsey, D. R., Jr.

    1975-01-01

    A mathematical model was developed of the three-dimensional dynamics of a high-altitude scientific research balloon system perturbed from its equilibrium configuration by an arbitrary gust loading. The platform is modelled as a system of four coupled pendula, and the equations of motion were developed in the Lagrangian formalism assuming a small-angle approximation. Three-dimensional pendulation, torsion, and precessional motion due to Coriolis forces are considered. Aerodynamic and viscous damping effects on the pendulatory and torsional motions are included. A general model of the gust field incident upon the balloon system was developed. The digital computer simulation program is described, and a guide to its use is given.

  11. Computer Simulation Study of Human Locomotion with a Three-Dimensional Entire-Body Neuro-Musculo-Skeletal Model

    NASA Astrophysics Data System (ADS)

    Hase, Kazunori; Obuchi, Shuichi

    The three-dimensional entire-body neuro-musculo-skeletal model generating normal walking motion was modified to synthesize pathological walking including asymmetricalcompensatorymotions. Inadditiontotheneuronalparameters, musculo-skeletal parameters were employed as search parameters to represent affected musculo-skeletal systems. This model successfully generated pathological walking patterns, such as walking by a person with one lower extremity shorter than the other and walking by a person with an affected gluteus medius muscle. The simulated walking patterns were of the entire body, three-dimensional, continuous and asymmetrical, and demonstrated the characteristics of actual pathological walking. The walking model with an artificial foot also predicted not only the walking pattern adapted to the artificial foot but also the design parameters of the artificial foot adapted to the effective walking pattern simultaneously. Such simulation methods will establish a novel methodology that we call computational rehabilitation engineering.

  12. Development of a three-dimensional Navier-Stokes code on CDC star-100 computer

    NASA Technical Reports Server (NTRS)

    Vatsa, V. N.; Goglia, G. L.

    1978-01-01

    A three-dimensional code in body-fitted coordinates was developed using MacCormack's algorithm. The code is structured to be compatible with any general configuration, provided that the metric coefficients for the transformation are available. The governing equations are developed in primitive variables in order to facilitate the incorporation of physical boundary conditions and turbulence-closure models. MacCormack's two-step, unsplit, time-marching algorithm is used to solve the unsteady Navier-Stokes equations until steady-state solution is achieved. Cases discussed include (1) flat plate in supersonic free stream; (2) supersonic flow along an axial corner; (3) subsonic flow in an axial corner at M infinity = 0.95; and (4) supersonic flow in an axial corner at M infinity 1.5.

  13. An efficient three-dimensional Poisson solver for SIMD high-performance-computing architectures

    NASA Technical Reports Server (NTRS)

    Cohl, H.

    1994-01-01

    We present an algorithm that solves the three-dimensional Poisson equation on a cylindrical grid. The technique uses a finite-difference scheme with operator splitting. This splitting maps the banded structure of the operator matrix into a two-dimensional set of tridiagonal matrices, which are then solved in parallel. Our algorithm couples FFT techniques with the well-known ADI (Alternating Direction Implicit) method for solving Elliptic PDE's, and the implementation is extremely well suited for a massively parallel environment like the SIMD architecture of the MasPar MP-1. Due to the highly recursive nature of our problem, we believe that our method is highly efficient, as it avoids excessive interprocessor communication.

  14. A Computational and Experimental Investigation of a Three-Dimensional Hypersonic Scramjet Inlet Flow Field. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Holland, Scott Douglas

    1991-01-01

    A combined computational and experimental parametric study of the internal aerodynamics of a generic three dimensional sidewall compression scramjet inlet configuration was performed. The study was designed to demonstrate the utility of computational fluid dynamics as a design tool in hypersonic inlet flow fields, to provide a detailed account of the nature and structure of the internal flow interactions, and to provide a comprehensive surface property and flow field database to determine the effects of contraction ratio, cowl position, and Reynolds number on the performance of a hypersonic scramjet inlet configuration.

  15. Three-dimensional digital-computer model of the principal ground-water reservoir of the Sevier Desert, Utah

    USGS Publications Warehouse

    Holmes, W.F.

    1983-01-01

    The principal ground-water reservoir in part of the Sevier Desert, Utah was modeled using a three-dimensional finite-difference model. The model was calibrated by comparing computed and observed water-level measurements in 1952, simulating results of aquifer tests, and simulating ground-water withdrawals during 1952-81 and comparing computed water-level changes during 1952-82 to observed changes. The results indicate the model is capable of predicting future water-level changes. The report includes a complete listing of the model data for the 1952-82 simulation. (USGS)

  16. Three-dimensional cone-beam computed tomography for assessment of mandibular changes after orthognathic surgery

    PubMed Central

    Cevidanes, Lucia H. S.; Bailey, L'Tanya J.; Tucker, Scott F.; Styner, Martin A.; Mol, Andre; Phillips, Ceib L.; Proffit, William R.; Turvey, Timothy

    2013-01-01

    Introduction The purpose of this study was to assess alterations in the 3-dimensional (3D) position of the mandibular rami and condyles in patients receiving either maxillary advancement and mandibular setback or maxillary surgery only. Methods High-resolution cone-beam computed tomography scans were taken of 21 patients before and after orthognathic surgery. Ten patients with various malocclusions underwent maxillary surgery only, and 11 Class III patients received maxillary advancement and mandibular setback. Presurgery and postsurgery 3D models were registered on the surface of the cranial base. A new tool was used for graphical overlay and 3D display with color maps to visually assess the locations and to quantify positional changes in the posterior border of the mandibular rami and condyles between superimposed models. Results The average displacements in condylar position were small—0.77 mm (SD, 0.12 mm) and 0.70 mm (SD, 0.08 mm)—for 2-jaw and 1-jaw surgeries, respectively (not significant, P >.05). All 2-jaw surgery patients had backward rotational displacements of the mandibular rami (mean, 1.98 mm; SD, 1.03 mm), with a maximum surface distance change of ≥2 mm in 8 of 11 subjects. For the 1-jaw surgery, all subjects had small backward rotational displacements of the mandibular rami (mean, 0.78 mm; SD, 0.25 mm), with only 1 subject having a maximum surface distance change ≥2 mm. The difference in mean backward rotational displacement was statistically significant (P <.01). Conclusions The visualization of 3D model superimposition clearly identified the location, magnitude, and direction of mandibular displacement. The 3D imaging allowed quantification of vertical, transverse, and anteroposterior ramus displacement that accompanied mandibular, but not maxillary only, surgery. PMID:17208105

  17. Parallel computation in a three-dimensional elastic-plastic finite-element analysis

    NASA Technical Reports Server (NTRS)

    Shivakumar, K. N.; Bigelow, C. A.; Newman, J. C., Jr.

    1992-01-01

    A CRAY parallel processing technique called autotasking was implemented in a three-dimensional elasto-plastic finite-element code. The technique was evaluated on two CRAY supercomputers, a CRAY 2 and a CRAY Y-MP. Autotasking was implemented in all major portions of the code, except the matrix equations solver. Compiler directives alone were not able to properly multitask the code; user-inserted directives were required to achieve better performance. It was noted that the connect time, rather than wall-clock time, was more appropriate to determine speedup in multiuser environments. For a typical example problem, a speedup of 2.1 (1.8 when the solution time was included) was achieved in a dedicated environment and 1.7 (1.6 with solution time) in a multiuser environment on a four-processor CRAY 2 supercomputer. The speedup on a three-processor CRAY Y-MP was about 2.4 (2.0 with solution time) in a multiuser environment.

  18. Comparison of Experimental Data and Computations Fluid Dynamics Analysis for a Three Dimensional Linear Plug Nozzle

    NASA Technical Reports Server (NTRS)

    Ruf, J. H.; Hagemann, G.; Immich, H.

    2003-01-01

    A three dimensional linear plug nozzle of area ratio 12.79 was designed by EADS Space Transportation (former Astrium Space Infrastructure). The nozzle was tested within the German National Technology Program 'LION' in a cold air wind tunnel by TU Dresden. The experimental hardware and test conditions are described. Experimental data was obtained for the nozzle without plug side wall fences at a nozzle pressure ratio of 116 and then with plug side wall fences at NPR 110. Schlieren images were recorded and axial profiles of plug wall static pressures were measured at several spanwise locations and on the plug base. Detailed CFD analysis was performed for these nozzle configurations at NPR 116 by NASA MSFC. The CFD exhibits good agreement with the experimental data. A detailed comparison of the CFD results and the experimental plug wall pressure data are given. Comparisons are made for both the without and with plug side wall fence configurations. Numerical results for density gradient are compared to experimental Schlieren images. Experimental nozzle thrust efficiencies are calculated based on the CFD results. The CFD results are used to illustrate the plug nozzle fluid dynamics. The effect of the plug side wall is emphasized.

  19. Computational studies of x-ray scattering from three-dimensionally-aligned asymmetric-top molecules.

    SciTech Connect

    Pabst, S.; Ho, P.; Santra, R.

    2010-01-01

    We theoretically and numerically analyze x-ray scattering from asymmetric-top molecules three-dimensionally aligned using elliptically polarized laser light. A rigid-rotor model is assumed. The principal axes of the polarizability tensor are assumed to coincide with the principal axes of the moment of inertia tensor. Several symmetries in the Hamiltonian are identified and exploited to enhance the efficiency of solving the time-dependent Schroedinger equation for each rotational state initially populated in a thermal ensemble. Using a phase-retrieval algorithm, the feasibility of structure reconstruction from a quasiadiabatically aligned sample is illustrated for the organic molecule naphthalene. The spatial resolution achievable strongly depends on the laser parameters, the initial rotational temperature, and the x-ray pulse duration. We demonstrate that for a laser peak intensity of 5 TW/cm{sup 2}, a laser pulse duration of 100 ps, a rotational temperature of 10 mK, and an x-ray pulse duration of 1 ps, the molecular structure may be probed at a resolution of 1 {angstrom}.

  20. Computational studies of x-ray scattering from three-dimensionally-aligned asymmetric-top molecules

    SciTech Connect

    Pabst, Stefan; Ho, Phay J.; Santra, Robin

    2010-04-15

    We theoretically and numerically analyze x-ray scattering from asymmetric-top molecules three-dimensionally aligned using elliptically polarized laser light. A rigid-rotor model is assumed. The principal axes of the polarizability tensor are assumed to coincide with the principal axes of the moment of inertia tensor. Several symmetries in the Hamiltonian are identified and exploited to enhance the efficiency of solving the time-dependent Schroedinger equation for each rotational state initially populated in a thermal ensemble. Using a phase-retrieval algorithm, the feasibility of structure reconstruction from a quasiadiabatically aligned sample is illustrated for the organic molecule naphthalene. The spatial resolution achievable strongly depends on the laser parameters, the initial rotational temperature, and the x-ray pulse duration. We demonstrate that for a laser peak intensity of 5 TW/cm{sup 2}, a laser pulse duration of 100 ps, a rotational temperature of 10 mK, and an x-ray pulse duration of 1 ps, the molecular structure may be probed at a resolution of 1 A ring .

  1. Computational tools for automated analysis of three-dimensional microstructural characterization data

    NASA Astrophysics Data System (ADS)

    Gulsoy, Emine Begum

    The correlations between a material's microstructure and its physical behavior are not always fully understood. The development of tools for the three-dimensional characterization of material microstructures, the automation and the quantification of these methods is investigated. The watershed transform and stochastic segmentation algorithms are applied to four different structures obtained using different types of serial sectioning. A nickel based superalloy, IN100 and a beta titanium structure, Ti-8823, recorded using Focused Ion Beam (FIB) serial sectioning; a beta processed titanium structure recorded using the Robo-Met.3D system; and a biological data set, an Arabidopsis cotyledon, recorded by optical sectioning via confocal microscopy. Results on the segmentation of the grains in IN100 data set, the segmentation of laths in a Ti-8823 data set, the segmentation of the basket weave colonies of a titanium microstructure and the determination of different cell types in a plant cotyledon are presented. A method, based on mutual information, to quantitatively describe the quality of the segmentation of microstructures and to compare different segmentation algorithms is introduced.

  2. Automated fit quantification of tibial nail designs during the insertion using computer three-dimensional modelling.

    PubMed

    Amarathunga, Jayani P; Schuetz, Michael A; Yarlagadda, Prasad Kvd; Schmutz, Beat

    2014-12-01

    Intramedullary nailing is the standard fixation method for displaced diaphyseal fractures of the tibia. An optimal nail design should both facilitate insertion and anatomically fit the bone geometry at its final position in order to reduce the risk of stress fractures and malalignments. Due to the nonexistence of suitable commercial software, we developed a software tool for the automated fit assessment of nail designs. Furthermore, we demonstrated that an optimised nail, which fits better at the final position, is also easier to insert. Three-dimensional models of two nail designs and 20 tibiae were used. The fitting was quantified in terms of surface area, maximum distance, sum of surface areas and sum of maximum distances by which the nail was protruding into the cortex. The software was programmed to insert the nail into the bone model and to quantify the fit at defined increment levels. On average, the misfit during the insertion in terms of the four fitting parameters was smaller for the Expert Tibial Nail Proximal bend (476.3 mm(2), 1.5 mm, 2029.8 mm(2), 6.5 mm) than the Expert Tibial Nail (736.7 mm(2), 2.2 mm, 2491.4 mm(2), 8.0 mm). The differences were statistically significant (p ≤ 0.05). The software could be used by nail implant manufacturers for the purpose of implant design validation.

  3. Computational studies of x-ray scattering from three-dimensionally-aligned asymmetric-top molecules

    NASA Astrophysics Data System (ADS)

    Pabst, Stefan; Ho, Phay; Santra, Robin

    2009-11-01

    We theoretically and numerically analyze x-ray scattering from asymmetric-top molecules three-dimensionally aligned using elliptically polarized laser light. A rigid-rotor model is assumed. The principal axes of the polarizability tensor are assumed to coincide with the principal axes of the moment of inertia tensor. Several symmetries in the Hamiltonian are identified and employed to enhance the efficiency of solving the time-dependent Schr"odinger equation for each rotational state initially populated in a thermal ensemble. Using a phase-retrieval algorithm, the feasibility of structure reconstruction from a quasi-adiabatically-aligned sample is illustrated for the organic molecule naphthalene. The spatial resolution achievable strongly depends on the laser parameters, the initial rotational temperature, and the x-ray pulse duration. We demonstrate that for a laser peak intensity of 5 TW/cm^2, a laser pulse duration of 100 ps, a rotational temperature of 10 mK, and an x-ray pulse duration of 1 ps, the molecular structure may be probed at a resolution of 1 å.

  4. Three-dimensional computed tomography angiography for the investigation of superficial temporal artery pseudoaneurysms--two case reports--.

    PubMed

    Higashino, Takuya; Kawashima, Masatou; Mannoji, Hiromichi

    2005-03-01

    An 89-year-old man and a 60-year-old man presented with superficial temporal artery (STA) pseudoaneurysms which developed secondary to trauma. Conventional cerebral angiography and three-dimensional computed tomography (3D CT) angiography clearly demonstrated the STA pseudoaneurysms. The patients underwent surgical excision of the aneurysms based on the conventional cerebral angiography findings in one patient and 3D CT angiography findings in other patient. 3D CT angiography is an excellent noninvasive diagnostic method for detecting extracranial aneurysms such as STA pseudoaneurysm, especially the relationship between the aneurysm and surrounding structures, including the calvarium.

  5. Computer investigation of the percolation processes in two- and three-dimensional systems with heterogeneous internal structure

    NASA Astrophysics Data System (ADS)

    Bagnich, S. A.; Konash, A. V.

    2003-04-01

    The results of computer investigation of the percolation processes in two- and three-dimensional heterogeneous lattices are presented. The heterogeneous condition is simulated by a random distribution of obstacles differing in size and number. The influence of obstacles on the parameters (critical concentration, average number of sites in finite clusters, percolation probability, critical exponents, and fractal and spectral dimensions of a percolation cluster) characterizing the percolation in the system is analyzed. It is demonstrated that all these parameters essentially depend on features of the heterogeneous internal structure (linear size and relative area of the obstacles) of the system.

  6. High spatial resolution three-dimensional mapping of vegetation spectral dynamics using computer vision and hobbyist unmanned aerial vehicles

    NASA Astrophysics Data System (ADS)

    Dandois, J. P.; Ellis, E. C.

    2013-12-01

    High spatial resolution three-dimensional (3D) measurements of vegetation by remote sensing are advancing ecological research and environmental management. However, substantial economic and logistical costs limit this application, especially for observing phenological dynamics in ecosystem structure and spectral traits. Here we demonstrate a new aerial remote sensing system enabling routine and inexpensive aerial 3D measurements of canopy structure and spectral attributes, with properties similar to those of LIDAR, but with RGB (red-green-blue) spectral attributes for each point, enabling high frequency observations within a single growing season. This 'Ecosynth' methodology applies photogrammetric ''Structure from Motion'' computer vision algorithms to large sets of highly overlapping low altitude (< 130 m) aerial photographs acquired using off-the-shelf digital cameras mounted on an inexpensive (< USD$4000), lightweight (< 2 kg), hobbyist-grade unmanned aerial system (UAS). Ecosynth 3D point clouds with densities of 30 - 67 points m-2 were produced using commercial computer vision software from digital photographs acquired repeatedly by UAS over three 6.25 ha (250 m x 250 m) Temperate Deciduous forest sites in Maryland USA. Ecosynth canopy height maps (CHMs) were strong predictors of field-measured tree heights (R2 0.63 to 0.84) and were highly correlated with a LIDAR CHM (R 0.87) acquired 4 days earlier, though Ecosynth-based estimates of aboveground biomass densities included significant errors (31 - 36% of field-based estimates). Repeated scanning of a 0.25 ha forested area at six different times across a 16 month period revealed ecologically significant dynamics in canopy color at different heights and a structural shift upward in canopy density, as demonstrated by changes in vertical height profiles of point density and relative RGB brightness. Changes in canopy relative greenness were highly correlated (R2 = 0.88) with MODIS NDVI time series for the same

  7. New technologies for advanced three-dimensional optimum shape design in aeronautics

    NASA Astrophysics Data System (ADS)

    Dervieux, Alain; Lanteri, Stéphane; Malé, Jean-Michel; Marco, Nathalie; Rostaing-Schmidt, Nicole; Stoufflet, Bruno

    1999-05-01

    The analysis of complex flows around realistic aircraft geometries is becoming more and more predictive. In order to obtain this result, the complexity of flow analysis codes has been constantly increasing, involving more refined fluid models and sophisticated numerical methods. These codes can only run on top computers, exhausting their memory and CPU capabilities. It is, therefore, difficult to introduce best analysis codes in a shape optimization loop: most previous works in the optimum shape design field used only simplified analysis codes. Moreover, as the most popular optimization methods are the gradient-based ones, the more complex the flow solver, the more difficult it is to compute the sensitivity code. However, emerging technologies are contributing to make such an ambitious project, of including a state-of-the-art flow analysis code into an optimisation loop, feasible. Among those technologies, there are three important issues that this paper wishes to address: shape parametrization, automated differentiation and parallel computing. Shape parametrization allows faster optimization by reducing the number of design variable; in this work, it relies on a hierarchical multilevel approach. The sensitivity code can be obtained using automated differentiation. The automated approach is based on software manipulation tools, which allow the differentiation to be quick and the resulting differentiated code to be rather fast and reliable. In addition, the parallel algorithms implemented in this work allow the resulting optimization software to run on increasingly larger geometries. Copyright

  8. Three-dimensional segmentation of pulmonary artery volume from thoracic computed tomography imaging

    NASA Astrophysics Data System (ADS)

    Lindenmaier, Tamas J.; Sheikh, Khadija; Bluemke, Emma; Gyacskov, Igor; Mura, Marco; Licskai, Christopher; Mielniczuk, Lisa; Fenster, Aaron; Cunningham, Ian A.; Parraga, Grace

    2015-03-01

    Chronic obstructive pulmonary disease (COPD), is a major contributor to hospitalization and healthcare costs in North America. While the hallmark of COPD is airflow limitation, it is also associated with abnormalities of the cardiovascular system. Enlargement of the pulmonary artery (PA) is a morphological marker of pulmonary hypertension, and was previously shown to predict acute exacerbations using a one-dimensional diameter measurement of the main PA. We hypothesized that a three-dimensional (3D) quantification of PA size would be more sensitive than 1D methods and encompass morphological changes along the entire central pulmonary artery. Hence, we developed a 3D measurement of the main (MPA), left (LPA) and right (RPA) pulmonary arteries as well as total PA volume (TPAV) from thoracic CT images. This approach incorporates segmentation of pulmonary vessels in cross-section for the MPA, LPA and RPA to provide an estimate of their volumes. Three observers performed five repeated measurements for 15 ex-smokers with ≥10 pack-years, and randomly identified from a larger dataset of 199 patients. There was a strong agreement (r2=0.76) for PA volume and PA diameter measurements, which was used as a gold standard. Observer measurements were strongly correlated and coefficients of variation for observer 1 (MPA:2%, LPA:3%, RPA:2%, TPA:2%) were not significantly different from observer 2 and 3 results. In conclusion, we generated manual 3D pulmonary artery volume measurements from thoracic CT images that can be performed with high reproducibility. Future work will involve automation for implementation in clinical workflows.

  9. Advances in three-dimensional rapid prototyping of microfluidic devices for biological applications

    PubMed Central

    O'Neill, P. F.; Ben Azouz, A.; Vázquez, M.; Liu, J.; Marczak, S.; Slouka, Z.; Chang, H. C.; Diamond, D.; Brabazon, D.

    2014-01-01

    The capability of 3D printing technologies for direct production of complex 3D structures in a single step has recently attracted an ever increasing interest within the field of microfluidics. Recently, ultrafast lasers have also allowed developing new methods for production of internal microfluidic channels within the bulk of glass and polymer materials by direct internal 3D laser writing. This review critically summarizes the latest advances in the production of microfluidic 3D structures by using 3D printing technologies and direct internal 3D laser writing fabrication methods. Current applications of these rapid prototyped microfluidic platforms in biology will be also discussed. These include imaging of cells and living organisms, electrochemical detection of viruses and neurotransmitters, and studies in drug transport and induced-release of adenosine triphosphate from erythrocytes. PMID:25538804

  10. Solving Navier-Stokes Equations with Advanced Turbulence Models on Three-Dimensional Unstructured Grids

    NASA Technical Reports Server (NTRS)

    Wang, Qun-Zhen; Massey, Steven J.; Abdol-Hamid, Khaled S.; Frink, Neal T.

    1999-01-01

    USM3D is a widely-used unstructured flow solver for simulating inviscid and viscous flows over complex geometries. The current version (version 5.0) of USM3D, however, does not have advanced turbulence models to accurately simulate complicated flows. We have implemented two modified versions of the original Jones and Launder k-epsilon two-equation turbulence model and the Girimaji algebraic Reynolds stress model in USM3D. Tests have been conducted for two flat plate boundary layer cases, a RAE2822 airfoil and an ONERA M6 wing. The results are compared with those of empirical formulae, theoretical results and the existing Spalart-Allmaras one-equation model.

  11. Continuous Three-Dimensional Control of a Virtual Helicopter Using a Motor Imagery Based Brain-Computer Interface

    PubMed Central

    Doud, Alexander J.; Lucas, John P.; Pisansky, Marc T.; He, Bin

    2011-01-01

    Brain-computer interfaces (BCIs) allow a user to interact with a computer system using thought. However, only recently have devices capable of providing sophisticated multi-dimensional control been achieved non-invasively. A major goal for non-invasive BCI systems has been to provide continuous, intuitive, and accurate control, while retaining a high level of user autonomy. By employing electroencephalography (EEG) to record and decode sensorimotor rhythms (SMRs) induced from motor imaginations, a consistent, user-specific control signal may be characterized. Utilizing a novel method of interactive and continuous control, we trained three normal subjects to modulate their SMRs to achieve three-dimensional movement of a virtual helicopter that is fast, accurate, and continuous. In this system, the virtual helicopter's forward-backward translation and elevation controls were actuated through the modulation of sensorimotor rhythms that were converted to forces applied to the virtual helicopter at every simulation time step, and the helicopter's angle of left or right rotation was linearly mapped, with higher resolution, from sensorimotor rhythms associated with other motor imaginations. These different resolutions of control allow for interplay between general intent actuation and fine control as is seen in the gross and fine movements of the arm and hand. Subjects controlled the helicopter with the goal of flying through rings (targets) randomly positioned and oriented in a three-dimensional space. The subjects flew through rings continuously, acquiring as many as 11 consecutive rings within a five-minute period. In total, the study group successfully acquired over 85% of presented targets. These results affirm the effective, three-dimensional control of our motor imagery based BCI system, and suggest its potential applications in biological navigation, neuroprosthetics, and other applications. PMID:22046274

  12. Three-Dimensional Imaging and Image Displays: Surgical Application of Advanced Technologies.

    PubMed

    Satava

    1996-09-01

    One of the cornerstones of modern technology that was ushered in by laparoscopic surgery is the use of the video image. The importance of this "virtual representation" of the patient goes well beyond the application to laparoscopic surgery, and lies at the very heart of the revolution of surgery into the Information Age. Real objects, organs and patients can be represented as 2 and 3-dimensional computer generated images and viewed upon displays beyond the simple video monitor which permit a level of clinical practice not possible on the actual patients. These fundamental concepts that form the foundation of the revolution in surgery are placed in a framework for the future of surgery, and illustrate how their implementation can dramatically improve patient care.

  13. On the effects of grid ill-conditioning in three dimensional finite element vector potential magnetostatic field computations

    NASA Technical Reports Server (NTRS)

    Wang, R.; Demerdash, N. A.

    1990-01-01

    The effects of finite element grid geometries and associated ill-conditioning were studied in single medium and multi-media (air-iron) three dimensional magnetostatic field computation problems. The sensitivities of these 3D field computations to finite element grid geometries were investigated. It was found that in single medium applications the unconstrained magnetic vector potential curl-curl formulation in conjunction with first order finite elements produce global results which are almost totally insensitive to grid geometries. However, it was found that in multi-media (air-iron) applications first order finite element results are sensitive to grid geometries and consequent elemental shape ill-conditioning. These sensitivities were almost totally eliminated by means of the use of second order finite elements in the field computation algorithms. Practical examples are given in this paper to demonstrate these aspects mentioned above.

  14. Comparison of two and three dimensional flow computations with laser anemometer measurements in a transonic compressor rotor

    NASA Technical Reports Server (NTRS)

    Chima, R. V.; Strazisar, A. J.

    1982-01-01

    A procedure for using an efficient axisymmetric code to generate downstream pressure input for more costly Euler codes is discussed. Two and three dimensional inviscid solutions for the flow within a transonic axial compressor rotor at design speed are compared to laser anemometer measurements at maximum flow and near stall operating points. Computational details of the 2-D axisymmetric stream function solution and the 3-D full Euler solution are described. Relative Mach number contours, shock location, and shock strength as measured and as predicted by the 3-D code are compared. Downstream of the rotor the inviscid computations agree with each other but predict higher pressure ratios than those measured. Euler codes require a downstream pressure as input. Since that pressure controls the computed mass flow and shock system, it must be consistent with an inviscid solution.

  15. An Elasticity-Based Mesh Scheme Applied to the Computation of Unsteady Three-Dimensional Spoiler and Aeroelastic Problems

    NASA Technical Reports Server (NTRS)

    Bartels, Robert E.

    1999-01-01

    This paper presents a modification of the spring analogy scheme which uses axial linear spring stiffness with selective spring stiffening/relaxation. An alternate approach to solving the geometric conservation law is taken which eliminates the need for storage of metric Jacobians at previous time steps. Efficiency and verification are illustrated with several unsteady 2-D airfoil Euler computations. The method is next applied to the computation of the turbulent flow about a 2-D airfoil and wing with two and three- dimensional moving spoiler surfaces, and the results compared with Benchmark Active Controls Technology (BACT) experimental data. The aeroelastic response at low dynamic pressure of an airfoil to a single large scale oscillation of a spoiler surface is computed. This study confirms that it is possible to achieve accurate solutions with a very large time step for aeroelastic problems using the fluid solver and aeroelastic integrator as discussed in this paper.

  16. Use of Multiple GPUs to Speedup the Execution of a Three-Dimensional Computational Model of the Innate Immune System

    NASA Astrophysics Data System (ADS)

    Xavier, M. P.; do Nascimento, T. M.; dos Santos, R. W.; Lobosco, M.

    2014-03-01

    The development of computational systems that mimics the physiological response of organs or even the entire body is a complex task. One of the issues that makes this task extremely complex is the huge computational resources needed to execute the simulations. For this reason, the use of parallel computing is mandatory. In this work, we focus on the simulation of temporal and spatial behaviour of some human innate immune system cells and molecules in a small three-dimensional section of a tissue. To perform this simulation, we use multiple Graphics Processing Units (GPUs) in a shared-memory environment. Despite of high initialization and communication costs imposed by the use of GPUs, the techniques used to implement the HIS simulator have shown to be very effective to achieve this purpose.

  17. COMMIX-PPC: A three-dimensional transient multicomponent computer program for analyzing performance of power plant condensers

    SciTech Connect

    Chien, T.H.; Domanus, H.M.; Sha, W.T.

    1993-02-01

    The COMMIX-PPC computer program is an extended and improved version of earlier COMMIX codes and is specifically designed for evaluating the thermal performance of power plant condensers. The COMMIX codes are general-purpose computer programs for the analysis of fluid flow and heat transfer in complex industrial systems. In COMMIX-PPC, two major features have been added to previously published COMMIX codes. One feature is the incorporation of one-dimensional conservation of mass. momentum, and energy equations on the tube side, and the proper accounting for the thermal interaction between shell and tube side through the porous medium approach. The other added feature is the extension of the three-dimensional conservation equations for shell-side flow to treat the flow of a multicomponent medium. COMMIX-PPC is designed to perform steady-state and transient three-dimensional analysis of fluid flow with heat transfer in a power plant condenser. However, the code is designed in a generalized fashion so that, with some modification. it can be used to analyze processes in any heat exchanger or other single-phase engineering applications.

  18. Multi-scale computational model of three-dimensional hemodynamics within a deformable full-body arterial network

    SciTech Connect

    Xiao, Nan; Humphrey, Jay D.; Figueroa, C. Alberto

    2013-07-01

    In this article, we present a computational multi-scale model of fully three-dimensional and unsteady hemodynamics within the primary large arteries in the human. Computed tomography image data from two different patients were used to reconstruct a nearly complete network of the major arteries from head to foot. A linearized coupled-momentum method for fluid–structure-interaction was used to describe vessel wall deformability and a multi-domain method for outflow boundary condition specification was used to account for the distal circulation. We demonstrated that physiologically realistic results can be obtained from the model by comparing simulated quantities such as regional blood flow, pressure and flow waveforms, and pulse wave velocities to known values in the literature. We also simulated the impact of age-related arterial stiffening on wave propagation phenomena by progressively increasing the stiffness of the central arteries and found that the predicted effects on pressure amplification and pulse wave velocity are in agreement with findings in the clinical literature. This work demonstrates the feasibility of three-dimensional techniques for simulating hemodynamics in a full-body compliant arterial network.

  19. COMMIX-PPC: A three-dimensional transient multicomponent computer program for analyzing performance of power plant condensers

    SciTech Connect

    Chien, T.H.; Domanus, H.M.; Sha, W.T.

    1993-02-01

    The COMMIX-PPC computer pregrain is an extended and improved version of earlier COMMIX codes and is specifically designed for evaluating the thermal performance of power plant condensers. The COMMIX codes are general-purpose computer programs for the analysis of fluid flow and heat transfer in complex Industrial systems. In COMMIX-PPC, two major features have been added to previously published COMMIX codes. One feature is the incorporation of one-dimensional equations of conservation of mass, momentum, and energy on the tube stile and the proper accounting for the thermal interaction between shell and tube side through the porous-medium approach. The other added feature is the extension of the three-dimensional conservation equations for shell-side flow to treat the flow of a multicomponent medium. COMMIX-PPC is designed to perform steady-state and transient. Three-dimensional analysis of fluid flow with heat transfer tn a power plant condenser. However, the code is designed in a generalized fashion so that, with some modification, it can be used to analyze processes in any heat exchanger or other single-phase engineering applications. Volume I (Equations and Numerics) of this report describes in detail the basic equations, formulation, solution procedures, and models for a phenomena. Volume II (User's Guide and Manual) contains the input instruction, flow charts, sample problems, and descriptions of available options and boundary conditions.

  20. Measurement of Three-dimensional Density Distributions by Holographic Interferometry and Computer Tomography

    NASA Technical Reports Server (NTRS)

    Vest, C. M.

    1982-01-01

    The use of holographic interferometry to measure two and threedimensional flows and the interpretation of multiple-view interferograms with computer tomography are discussed. Computational techniques developed for tomography are reviewed. Current research topics are outlined including the development of an automated fringe readout system, optimum reconstruction procedures for when an opaque test model is present in the field, and interferometry and tomography with strongly refracting fields and shocks.

  1. Performing three-dimensional neutral particle transport calculations on tera scale computers

    SciTech Connect

    Woodward, C S; Brown, P N; Chang, B; Dorr, M R; Hanebutte, U R

    1999-01-12

    A scalable, parallel code system to perform neutral particle transport calculations in three dimensions is presented. To utilize the hyper-cluster architecture of emerging tera scale computers, the parallel code successfully combines the MPI message passing and paradigms. The code's capabilities are demonstrated by a shielding calculation containing over 14 billion unknowns. This calculation was accomplished on the IBM SP ''ASCI-Blue-Pacific computer located at Lawrence Livermore National Laboratory (LLNL).

  2. Computer Simulation Study of Human Locomotion with a Three-Dimensional Entire-Body Neuro-Musculo-Skeletal Model

    NASA Astrophysics Data System (ADS)

    Hase, Kazunori; Obinata, Goro

    It is essential for the biomechanical study of human walking motion to consider not only in vivo mechanical load and energy efficiency but also aspects of motor control such as walking stability. In this study, walking stability was investigated using a three-dimensional entire-body neuro-musculo-skeletal model in the computer simulation. In the computational experiments, imaginary constraints, such as no muscular system, were set in the neuro-musculo-skeletal model to investigate their influence on walking stability. The neuronal parameters were adjusted using numerical search techniques in order to adapt walking patterns to constraints on the neuro-musculo-skeletal system. Simulation results revealed that the model of the normal neuro-musculo-skeletal system yielded a higher stability than the imaginary models. Unstable walking by a model with a time delay in the neuronal system suggested significant unknown mechanisms which stabilized walking patterns that have been neglected in previous studies.

  3. Computational algorithms for increased control of depth-viewing volume for stereo three-dimensional graphic displays

    NASA Technical Reports Server (NTRS)

    Williams, Steven P.; Parrish, Russell V.

    1992-01-01

    Three-dimensional pictorial displays incorporating depth cues by means of stereopsis offer a potential means of presenting information in a natural way to enhance situational awareness and improve operator performance. Conventional computational techniques rely on asymptotic projection transformations and symmetric clipping to produce the stereo display. Implementation of two new computational techniques, as asymmetric clipping algorithm and piecewise linear projection transformation, provides the display designer with more control and better utilization of the effective depth-viewing volume to allow full exploitation of stereopsis cuing. Asymmetric clipping increases the perceived field of view (FOV) for the stereopsis region. The total horizontal FOV provided by the asymmetric clipping algorithm is greater throughout the scene viewing envelope than that of the symmetric algorithm. The new piecewise linear projection transformation allows the designer to creatively partition the depth-viewing volume, with freedom to place depth cuing at the various scene distances at which emphasis is desired.

  4. A novel three-dimensional imaging method by means of coded cameras array recording and computational reconstruction

    NASA Astrophysics Data System (ADS)

    Lang, Haitao; Liu, Liren; Yang, Qingguo

    2007-04-01

    In this paper, we propose a novel three-dimensional imaging method by which the object is captured by a coded cameras array (CCA) and computationally reconstructed as a series of longitudinal layered surface images of the object. The distribution of cameras in array, named code pattern, is crucial for reconstructed images fidelity when the correlation decoding is used. We use DIRECT global optimization algorithm to design the code patterns that possess proper imaging property. We have conducted primary experiments to verify and test the performance of the proposed method with a simple discontinuous object and a small-scale CCA including nine cameras. After certain procedures such as capturing, photograph integrating, computational reconstructing and filtering, etc., we obtain reconstructed longitudinal layered surface images of the object with higher signal-to-noise ratio. The results of experiments show that the proposed method is feasible. It is a promising method to be used in fields such as remote sensing, machine vision, etc.

  5. Three-dimensional compressible turbulent computations for a diffusing S-duct

    NASA Technical Reports Server (NTRS)

    Smith, C. F.; Bruns, J. E.; Harloff, G. J.; Debonis, J. R.

    1992-01-01

    The purpose of the present study was to evaluate the capability of the computational fluid dynamics computer program PARC3D to model flow in a typical diffusing subsonic S-duct, with strong secondary flows. This evaluation is needed to provide confidence in the analysis of aircraft inlets, which have similar geometries. The performance predictions include total pressure profiles, static pressures, velocity profiles, boundary layer data, and skin friction data. Flow in the S-duct is subsonic, and the boundary layers are assumed to be turbulent. The results for both H and O grid solutions, are compared with existing test data.

  6. Computational Methods for Inviscid and Viscous Two-and-Three-Dimensional Flow Fields.

    DTIC Science & Technology

    1975-01-01

    speeds. J. Comput. Phys.. vol. 3. No. 2. 1971, p. 197-213. 111. HANIN. M.. WOLFSHTEIN. M.. and LANDAU . U.E. - Numerical solution of NavierStokes...viscous in lungul unei placi plane la numere Reynolds mici) D. Dumitrescu and C.I. Craciun Studii si Cercetari de Mecanica Aplicata, vol. 28, no. 3

  7. THREE-DIMENSIONAL COMPUTER MODELING OF THE HUMAN UPPER RESPIRATORY TRACT

    EPA Science Inventory

    ABSTRACT
    Computer simulations of airflow and particle transport phenomena within the human respiratory system have important applications to aerosol therapy (e.g., the targeted delivery of inhaled drugs) and inhalation toxicology (e.g., the risk assessment of air pollutants). ...

  8. Three-Dimensional Computer Animated Graphics: A Tool for Spatial Skill Instruction.

    ERIC Educational Resources Information Center

    Zavotka, Susan Lee

    1987-01-01

    Describes study of home economics students at Ohio State University that investigated whether computer animated graphics that replicate mental images of rotation and dimensional transformation would be useful in the development of spatial skills. Orthographic drawings are described, and results for treatment and control groups are analyzed. (29…

  9. The Basic Concepts of Three-Dimensional Computer Graphics for Artists.

    ERIC Educational Resources Information Center

    Sachter, Judy E.

    Arguing that an artist using any new medium must understand its techniques and limitations, this master's thesis is intended to demystify state-of-the-art 3-D computer graphics through a discussion of the technical literature from the artist's point of view and an analysis of the curricular needs of the artist. The first of six chapters discusses…

  10. Three-dimensional Computational Fluid Dynamics Investigation of a Spinning Helicopter Slung Load

    NASA Technical Reports Server (NTRS)

    Theorn, J. N.; Duque, E. P. N.; Cicolani, L.; Halsey, R.

    2005-01-01

    After performing steady-state Computational Fluid Dynamics (CFD) calculations using OVERFLOW to validate the CFD method against static wind-tunnel data of a box-shaped cargo container, the same setup was used to investigate unsteady flow with a moving body. Results were compared to flight test data previously collected in which the container is spinning.

  11. Computational methods for a three-dimensional model of the petroleum-discovery process

    USGS Publications Warehouse

    Schuenemeyer, J.H.; Bawiec, W.J.; Drew, L.J.

    1980-01-01

    A discovery-process model devised by Drew, Schuenemeyer, and Root can be used to predict the amount of petroleum to be discovered in a basin from some future level of exploratory effort: the predictions are based on historical drilling and discovery data. Because marginal costs of discovery and production are a function of field size, the model can be used to make estimates of future discoveries within deposit size classes. The modeling approach is a geometric one in which the area searched is a function of the size and shape of the targets being sought. A high correlation is assumed between the surface-projection area of the fields and the volume of petroleum. To predict how much oil remains to be found, the area searched must be computed, and the basin size and discovery efficiency must be estimated. The basin is assumed to be explored randomly rather than by pattern drilling. The model may be used to compute independent estimates of future oil at different depth intervals for a play involving multiple producing horizons. We have written FORTRAN computer programs that are used with Drew, Schuenemeyer, and Root's model to merge the discovery and drilling information and perform the necessary computations to estimate undiscovered petroleum. These program may be modified easily for the estimation of remaining quantities of commodities other than petroleum. ?? 1980.

  12. Three-Dimensional Effects on Multi-Element High Lift Computations

    NASA Technical Reports Server (NTRS)

    Rumsey, Christopher L.; Lee-Rausch, Elizabeth M.; Watson, Ralph D.

    2002-01-01

    In an effort to discover the causes for disagreement between previous 2-D computations and nominally 2-D experiment for flow over the 3-clement McDonnell Douglas 30P-30N airfoil configuration at high lift, a combined experimental/CFD investigation is described. The experiment explores several different side-wall boundary layer control venting patterns, document's venting mass flow rates, and looks at corner surface flow patterns. The experimental angle of attack at maximum lift is found to be sensitive to the side wall venting pattern: a particular pattern increases the angle of attack at maximum lift by at least 2 deg. A significant amount of spanwise pressure variation is present at angles of attack near maximum lift. A CFD study using 3-D structured-grid computations, which includes the modeling of side-wall venting, is employed to investigate 3-D effects of the flow. Side-wall suction strength is found to affect the angle at which maximum lift is predicted. Maximum lift in the CFD is shown to be limited by the growth of all off-body corner flow vortex and consequent increase in spanwise pressure variation and decrease in circulation. The 3-D computations with and without wall venting predict similar trends to experiment at low angles of attack, but either stall too earl or else overpredict lift levels near maximum lift by as much as 5%. Unstructured-grid computations demonstrate that mounting brackets lower die the levels near maximum lift conditions.

  13. Effects of nasal septum perforation repair surgery on three-dimensional airflow: an evaluation using computational fluid dynamics.

    PubMed

    Nomura, Tsutomu; Ushio, Munetaka; Kondo, Kenji; Yamasoba, Tatsuya

    2015-11-01

    The purpose of this research is to determine the cause of nasal perforation symptoms and to predict post-operative function after nasal perforation repair surgery. A realistic three-dimensional (3D) model of the nose with a septal perforation was reconstructed using a computed tomography (CT) scan from a patient with nasal septal defect. The numerical simulation was carried out using ANSYS CFX V13.0. Pre- and post-operative models were compared by their velocity, pressure gradient (PG), wall shear (WS), shear strain rate (SSR) and turbulence kinetic energy in three plains. In the post-operative state, the crossflows had disappeared, and stream lines bound to the olfactory cleft area had appeared. After surgery, almost all of high-shear stress areas were disappeared comparing pre-operative model. In conclusion, the effects of surgery to correct nasal septal perforation were evaluated using a three-dimensional airflow evaluation. Following the surgery, crossflows disappeared, and WS, PG and SSR rate were decreased. A high WS.PG and SSR were suspected as causes of nasal perforation symptoms.

  14. Animated visualization of a high resolution color three dimensional digital computer model of the whole human head.

    PubMed

    Narayan, S; Sensharma, D; Santori, E M; Lee, A A; Sabherwal, A; Toga, A W

    1993-01-01

    The interactive visualization of animated images through a computerized three dimensional (3D) full color model of an unstained cadaveric human head is presented. Serial full color images were taken of the blockface of a cryomicrotomed frozen human head every 200 microns. From this series of images a three dimensional digital model with a resultant pixel resolution of 200 microns3 was created on a UNIX workstation. Using this database, resampled images were computed along orthogonal axes and written sequentially to a write-once-read-many times (WORM) videodisc unit. Playback of this customized videodisc dataset provides animations of the digitally reconstructed slices and 3D reconstructed surface models. An interactive interface to the animated sequences is provided through a PC based tutorial package. This tutorial program is able to access videodisc frames to display animations and labeled still images in a software window to illustrate various neuroanatomic topics. The technique of animation as applied to this high resolution 3D model provides insight into complex spatial relationships and has great potential in research and as a teaching tool in the neurosciences.

  15. A three-dimensional transient neutronics routine for the TRAC-PF1 reactor thermal hydraulic computer code

    SciTech Connect

    Bandini, B.R.

    1990-05-01

    No present light water reactor accident analysis code employs both high state of the art neutronics and thermal-hydraulics computational algorithms. Adding a modern three-dimensional neutron kinetics model to the present TRAC-PFI/MOD2 code would create a fully up to date pressurized water reactor accident evaluation code. After reviewing several options, it was decided that the Nodal Expansion Method would best provide the basis for this multidimensional transient neutronic analysis capability. Steady-state and transient versions of the Nodal Expansion Method were coded in both three-dimensional Cartesian and cylindrical geometries. In stand-alone form this method of solving the few group neutron diffusion equations was shown to yield efficient and accurate results for a variety of steady-state and transient benchmark problems. The Nodal Expansion Method was then incorporated into TRAC-PFl/MOD2. The combined NEM/TRAC code results agreed well with the EPRI-ARROTTA core-only transient analysis code when modelling a severe PWR control rod ejection accident.

  16. Computational experience with a three-dimensional rotary engine combustion model

    NASA Technical Reports Server (NTRS)

    Raju, M. S.; Willis, E. A.

    1990-01-01

    A new computer code was developed to analyze the chemically reactive flow and spray combustion processes occurring inside a stratified-charge rotary engine. Mathematical and numerical details of the new code were recently described by the present authors. The results are presented of limited, initial computational trials as a first step in a long-term assessment/validation process. The engine configuration studied was chosen to approximate existing rotary engine flow visualization and hot firing test rigs. Typical results include: (1) pressure and temperature histories, (2) torque generated by the nonuniform pressure distribution within the chamber, (3) energy release rates, and (4) various flow-related phenomena. These are discussed and compared with other predictions reported in the literature. The adequacy or need for improvement in the spray/combustion models and the need for incorporating an appropriate turbulence model are also discussed.

  17. Computer analysis of three-dimensional morphological characteristics of the bile duct

    NASA Astrophysics Data System (ADS)

    Ma, Jinyuan; Chen, Houjin; Peng, Yahui; Shang, Hua

    2017-01-01

    In this paper, a computer image-processing algorithm for analyzing the morphological characteristics of bile ducts in Magnetic Resonance Cholangiopancreatography (MRCP) images was proposed. The algorithm consisted of mathematical morphology methods including erosion, closing and skeletonization, and a spline curve fitting method to obtain the length and curvature of the center line of the bile duct. Of 10 cases, the average length of the bile duct was 14.56 cm. The maximum curvature was in the range of 0.111 2.339. These experimental results show that using the computer image-processing algorithm to assess the morphological characteristics of the bile duct is feasible and further research is needed to evaluate its potential clinical values.

  18. SALE-3D: a simplified ALE computer program for calculating three-dimensional fluid flow

    SciTech Connect

    Amsden, A.A.; Ruppel, H.M.

    1981-11-01

    This report presents a simplified numerical fluid-dynamics computing technique for calculating time-dependent flows in three dimensions. An implicit treatment of the pressure equation permits calculation of flows far subsonic without stringent constraints on the time step. In addition, the grid vertices may be moved with the fluid in Lagrangian fashion or held fixed in an Eulerian manner, or moved in some prescribed manner to give a continuous rezoning capability. This report describes the combination of Implicit Continuous-fluid Eulerian (ICE) and Arbitrary Lagrangian-Eulerian (ALE) to form the ICEd-ALE technique in the framework of the Simplified-ALE (SALE-3D) computer program, for which a general flow diagram and complete FORTRAN listing are included. Sample problems show how to modify the code for a variety of applications. SALE-3D is patterned as closely as possible on the previously reported two-dimensional SALE program.

  19. Three-dimensional elliptic grid generation about fighter aircraft for zonal finite-difference computations

    NASA Technical Reports Server (NTRS)

    Sorenson, R. L.

    1986-01-01

    An elliptic grid-generation method for finite-difference computations about complex aerodynamic configurations is developed. A zonal approach is used, which involves first making a coarse global grid filling the entire physical domain and then subdividing regions of that grid to make the individual zone grids. The details of the grid-generation method are presented along with results of the present application, a wing-body configuration based on the F-16 fighter aircraft.

  20. Manual of phosphoric acid fuel cell stack three-dimensional model and computer program

    NASA Technical Reports Server (NTRS)

    Lu, C. Y.; Alkasab, K. A.

    1984-01-01

    A detailed distributed mathematical model of phosphoric acid fuel cell stack have been developed, with the FORTRAN computer program, for analyzing the temperature distribution in the stack and the associated current density distribution on the cell plates. Energy, mass, and electrochemical analyses in the stack were combined to develop the model. Several reasonable assumptions were made to solve this mathematical model by means of the finite differences numerical method.

  1. A High Resolution, Three-Dimensional, Computationally Efficient, Diagnostic Wind Model: Initial Development Report

    DTIC Science & Technology

    2003-10-01

    reasonably accurate in representing the flow physics and computationally efficient. The basic framework of the model is discussed in this document... Basically , this version of the model takes about 20 to 30 times more CPU time to 17 run, compared with the latest model version implemented with the...free or surface-mounted obstacles: applying topology to flow visulization . J. Fluid Mech. 1978, 86, pp 179-200. Kastner-Klein, P.; Rotach, M. W

  2. Computation of the eddy-current modes of three-dimensional conducting bodies

    NASA Astrophysics Data System (ADS)

    Gabbay, Jonathan E.; Scott, Waymond R.

    2016-05-01

    Low-frequency electromagnetic induction (EMI) sensors are commonly used in subsurface detection applications because of their efficacy at detecting even small fragments of metal when they are buried near the surface. This efficacy can become a shortcoming when the detector is expected to locate specific classes of targets that are buried among metallic clutter. For these applications, broadband EMI sensors have shown considerable promise at being able to detect, classify and locate targets such as land mines, and discriminate between them and the clutter with low false-alarm rates. In such cases, where differentiating targets from clutter is a significant obstacle, detection strategies based on the discrete spectrum of relaxation frequencies (DSRF) have been shown to be highly effective. For such purposes, a dictionary of DSRF of targets of interest must be computed a priori. Several classes of targets such as sphere and rings have DSRF that can be derived analytically, however, in general, the DSRF must be computed numerically. Previously, numerical strategies have been presented for thin conducting shells and rotationaly symmetric targets. In this paper, we will present a strategy to compute the DSRF of arbitrary conducting targets using a null space free Jacobi Davidson iteration (NFJD).

  3. Postoperative Three-Dimensional Evaluation of Mandibular Contouring Surgery Using Computer-Assisted Simulation Planning and a Three-Dimensional-Printed Surgical Guide.

    PubMed

    Seok, Hyun; Kim, Seong-Gon; Park, Young-Wook; Lee, Yong-Chan

    2017-01-23

    Mandibular contouring surgery was performed using computer-assisted simulation planning (CASP) and 3-dimensional printed surgical guide. The outcome of the surgery was evaluated by overlapping preoperative image. The patient underwent mandibular contouring surgery according to CASP for his residual facial asymmetry of the mandibular angle and mental area. The overall facial aesthetic of the patient was improved. In the overlapping image, the left mandibular border area was slightly overcorrected. However, the other portion was operated as planned. The overcorrection was due to the improper adaptation of the surgical guide adjacent to the mental foramen. In conclusion, usage of CASP and a surgical guide could reduce operation time and increase the accuracy of the operation. However, the design of the stent should be improved around the mental foramen to avoid nerve damage and improper adaptation.

  4. Computational strategies for three-dimensional flow simulations on distributed computer systems. Ph.D. Thesis Semiannual Status Report, 15 Aug. 1993 - 15 Feb. 1994

    NASA Technical Reports Server (NTRS)

    Weed, Richard Allen; Sankar, L. N.

    1994-01-01

    An increasing amount of research activity in computational fluid dynamics has been devoted to the development of efficient algorithms for parallel computing systems. The increasing performance to price ratio of engineering workstations has led to research to development procedures for implementing a parallel computing system composed of distributed workstations. This thesis proposal outlines an ongoing research program to develop efficient strategies for performing three-dimensional flow analysis on distributed computing systems. The PVM parallel programming interface was used to modify an existing three-dimensional flow solver, the TEAM code developed by Lockheed for the Air Force, to function as a parallel flow solver on clusters of workstations. Steady flow solutions were generated for three different wing and body geometries to validate the code and evaluate code performance. The proposed research will extend the parallel code development to determine the most efficient strategies for unsteady flow simulations.

  5. Three-dimensional pore space quantification of apple tissue using X-ray computed microtomography.

    PubMed

    Mendoza, Fernando; Verboven, Pieter; Mebatsion, Hibru K; Kerckhofs, Greet; Wevers, Martine; Nicolaï, Bart

    2007-08-01

    The microstructure and the connectivity of the pore space are important variables for better understanding of the complex gas transport phenomena that occur in plant tissues. In this study, we present an experimental procedure for image acquisition and image processing to quantitatively characterize in 3D the pore space of apple tissues (Malus domestica Borkh.) for two cultivars (Jonagold and Braeburn) taken from the fleshy part of the cortex using X-ray computer microtomography. Preliminary sensitivity analyses were performed to determine the effect of the resolution and the volume size (REV, representative elementary volume analysis) on the computed porosity of apple samples. For comparison among cultivars, geometrical properties such as porosity, specific surface area, number of disconnected pore volumes and their distribution parameters were extracted and analyzed in triplicate based on the 3D skeletonization of the pore space (medial axis analysis). The results showed that microtomography provides a resolution at the micrometer level to quantitatively analyze and characterize the 3D topology of the pore space in apple tissue. The computed porosity was confirmed to be highly dependent of the resolution used, and the minimum REV of the cortical flesh of apple fruit was estimated to be 1.3 mm(3). Comparisons among the two cultivars using a resolution of 8.5 mum with a minimum REV cube showed that in spite of the complexity and variability of the pore space network observed in Jonagold and Braeburn apples, the extracted parameters from the medial axis were significantly different (P-value < 0.05). Medial axis parameters showed potential to differentiate the microstructure between the two evaluated apple cultivars.

  6. Steady and unsteady three-dimensional transonic flow computations by integral equation method

    NASA Technical Reports Server (NTRS)

    Hu, Hong

    1994-01-01

    This is the final technical report of the research performed under the grant: NAG1-1170, from the National Aeronautics and Space Administration. The report consists of three parts. The first part presents the work on unsteady flows around a zero-thickness wing. The second part presents the work on steady flows around non-zero thickness wings. The third part presents the massively parallel processing implementation and performance analysis of integral equation computations. At the end of the report, publications resulting from this grant are listed and attached.

  7. Level set discrete element method for three-dimensional computations with triaxial case study

    NASA Astrophysics Data System (ADS)

    Kawamoto, Reid; Andò, Edward; Viggiani, Gioacchino; Andrade, José E.

    2016-06-01

    In this paper, we outline the level set discrete element method (LS-DEM) which is a discrete element method variant able to simulate systems of particles with arbitrary shape using level set functions as a geometric basis. This unique formulation allows seamless interfacing with level set-based characterization methods as well as computational ease in contact calculations. We then apply LS-DEM to simulate two virtual triaxial specimens generated from XRCT images of experiments and demonstrate LS-DEM's ability to quantitatively capture and predict stress-strain and volume-strain behavior observed in the experiments.

  8. Three-dimensional Computational Fluid Dynamics (CFD) modeling of dry spent nuclear fuel storage canisters

    SciTech Connect

    Lee, S.Y.

    1997-06-01

    One of the interim storage configurations being considered for aluminum-clad foreign research reactor fuel, such as the Material and Testing Reactor (MTR) design, is in a dry storage facility. To support design studies of storage options, a computational and experimental program was conducted at the Savannah River Site (SRS). The objective was to develop computational fluid dynamics (CFD) models which would be benchmarked using data obtained from a full scale heat transfer experiment conducted in the SRS Experimental Thermal Fluids Laboratory. The current work documents the CFD approach and presents comparison of results with experimental data. CFDS-FLOW3D (version 3.3) CFD code has been used to model the 3-dimensional convective velocity and temperature distributions within a single dry storage canister of MTR fuel elements. For the present analysis, the Boussinesq approximation was used for the consideration of buoyancy-driven natural convection. Comparison of the CFD code can be used to predict reasonably accurate flow and thermal behavior of a typical foreign research reactor fuel stored in a dry storage facility.

  9. Computational and Experimental Analysis of Fluid Transport Through Three-Dimensional Collagen-Matrigel Hydrogels.

    PubMed

    Marshall, Lauren E; Koomullil, Roy; Frost, Andra R; Berry, Joel L

    2017-04-01

    A preclinical testing model for cancer therapeutics that replicates in vivo physiology is needed to accurately describe drug delivery and efficacy prior to clinical trials. To develop an in vitro model of breast cancer that mimics in vivo drug/nutrient delivery as well as physiological size and bio-composition, it is essential to describe the mass transport quantitatively. The objective of the present study was to develop in vitro and computational models to measure mass transport from a perfusion system into a 3D extracellular matrix (ECM). A perfusion-flow bioreactor system was used to control and quantify the mass transport of a macromolecule within an ECM hydrogel with embedded through-channels. The material properties, fluid mechanics, and structure of the construct quantified in the in vitro model were input into, and served as validation of, the computational fluid dynamics (CFD) simulation. Results showed that advection and diffusion played a complementary role in mass transport. As the CFD simulation becomes more complex with embedded blood vessels and cancer cells, it will become more recapitulative of in vivo breast cancers. This study is a step toward development of a preclinical testing platform that will be more predictive of patient response to therapeutics than two-dimensional cell culture.

  10. GPU-accelerated model for fast, three-dimensional fluid-structure interaction computations.

    PubMed

    Nita, Cosmin; Itu, Lucian; Mihalef, Viorel; Sharma, Puneet; Rapaka, Saikiran

    2015-08-01

    In this paper we introduce a methodology for performing one-way Fluid-Structure interaction (FSI), i.e. where the motion of the wall boundaries is imposed. We use a Graphics Processing Unit (GPU) accelerated Lattice-Boltzmann Method (LBM) implementation and present an efficient workflow for embedding the moving geometry, given as a set of polygonal meshes, in the LBM computation. The proposed method is first validated in a synthetic experiment: a vessel which is periodically expanding and contracting. Next, the evaluation focuses on the 3D Peristaltic flow problem: a fluid flows inside a flexible tube, where a periodic wave-like deformation produces a fluid motion along the centerline of the tube. Different geometry configurations are used and results are compared against previously published solutions. The efficient approach leads to an average execution time of approx. one hour per computation, whereas 50% of it is required for the geometry update operations. Finally, we also analyse the effect of changing the Reynolds number on the flow streamlines: the flow regime is significantly affected by the Reynolds number.

  11. Computer-assisted three-dimensional surgical planning: 3D virtual articulator: technical note.

    PubMed

    Ghanai, S; Marmulla, R; Wiechnik, J; Mühling, J; Kotrikova, B

    2010-01-01

    This study presents a computer-assisted planning system for dysgnathia treatment. It describes the process of information gathering using a virtual articulator and how the splints are constructed for orthognathic surgery. The deviation of the virtually planned splints is shown in six cases on the basis of conventionally planned cases. In all cases the plaster models were prepared and scanned using a 3D laser scanner. Successive lateral and posterior-anterior cephalometric images were used for reconstruction before surgery. By identifying specific points on the X-rays and marking them on the virtual models, it was possible to enhance the 2D images to create a realistic 3D environment and to perform virtual repositioning of the jaw. A hexapod was used to transfer the virtual planning to the real splints. Preliminary results showed that conventional repositioning could be replicated using the virtual articulator.

  12. Analysis of rotary engine combustion processes based on unsteady, three-dimensional computations

    NASA Technical Reports Server (NTRS)

    Raju, M. S.; Willis, E. A.

    1989-01-01

    A new computer code was developed for predicting the turbulent, and chemically reacting flows with sprays occurring inside of a stratified charge rotary engine. The solution procedure is based on an Eulerian Lagrangian approach where the unsteady, 3-D Navier-Stokes equations for a perfect gas mixture with variable properties are solved in generalized, Eulerian coordinates on a moving grid by making use of an implicit finite volume, Steger-Warming flux vector splitting scheme, and the liquid phase equations are solved in Lagrangian coordinates. Both the details of the numerical algorithm and the finite difference predictions of the combustor flow field during the opening of exhaust and/or intake, and also during fuel vaporization and combustion, are presented.

  13. Influence of trailing edge flap on wind turbine blade using three-dimensional computational fluid dynamics method

    NASA Astrophysics Data System (ADS)

    Li, C. F.; Xu, Y.; Zhao, X. L.; Xu, J. Z.

    2013-12-01

    This paper investigates the influence of the trailing edge flap on integrated loads and the flow field structure of wind turbine blades. The dynamic trailing edge flap under sinusoidal wind velocity is simulated using three-dimensional computational fluid dynamics method, and SST k-ω turbulence model coupled with γ-Reθ transition model is adopted to model the turbulence. The results show that the variation of root flap bending moments can be reduced by up to 38%. A proper phase difference added to the flap deflection could improve the ability of loads reduction for some cases. The flap deflection impacts almost all sections of the blade, and the blade elements momentum method should be modified to obtain better results.

  14. Three-dimensional rendering of computer-generated holograms acquired from point-clouds on light field displays

    NASA Astrophysics Data System (ADS)

    Symeonidou, Athanasia; Blinder, David; Ceulemans, Beerend; Munteanu, Adrian; Schelkens, Peter

    2016-09-01

    Holograms, either optically acquired or simulated numerically from 3D datasets, such as point clouds, have special rendering requirements for display. Evaluating the quality of hologram generation techniques is not straightforward, since high-quality holographic display technologies are still immature, In this paper we present a framework for three-dimensional rendering of colour computer-generated holograms (CGHs) acquired from point-clouds, on high-end light field displays. This allows for the rendering of holographic content with horizontal parallax and wide viewing angle. We deploy prior work, namely a fast CGH method that inherently handles occlusion problems to acquire high quality colour holograms from point clouds. Our experiments showed that rendering holograms with the proposed framework provides 3D effect with depth disparity and horizontal-only with wide viewing angle. Therefore, it allows for the evaluation of CGH techniques regarding functional properties such as depth cues and efficient occlusion handling.

  15. COMMIX-SA-1: a three-dimensional thermohydrodynamic computer program for solar applications. [Heat-storage water tanks

    SciTech Connect

    Sha, W.T.; Lin, E.I.H.; Schmitt, R.C.; Liu, K.V.; Hull, J.R.; Oras, J.J. Jr.; Domanus, H.M.

    1980-11-01

    COMMIX-SA-1 is a three-dimensional, transient, single-phase, compressible-flow, component computer program for thermohydrodynamic analysis. It was developed for solar applications in general, and for analysis of thermocline storage tanks in particular. The conservation equations (in cylindrical coordinates) for mass, momentum, and energy are solved as an initial-boundary-value problem. The detailed numerical-solution procedure based on a modified ICE (Implicit Continuous-Fluid Eulerian) technique is described. A method for treating the singularity problem arising at the origin of a cylindrical-coordinate system is presented. In addition, the thermal interactions between fluid and structures (tank walls, baffles, etc.) are explicitly accounted for. Finally, the COMMIX-SA-1 code structure is delineated, and an input description and sample problems are presented.

  16. Computer program for calculating full potential transonic, quasi-three-dimensional flow through a rotating turbomachinery blade row

    NASA Technical Reports Server (NTRS)

    Farrell, C. A.

    1982-01-01

    A fast, reliable computer code is described for calculating the flow field about a cascade of arbitrary two dimensional airfoils. The method approximates the three dimensional flow in a turbomachinery blade row by correcting for stream tube convergence and radius change in the throughflow direction. A fully conservative solution of the full potential equation is combined with the finite volume technique on a body-fitted periodic mesh, with an artificial density imposed in the transonic region to insure stability and the capture of shock waves. The instructions required to set up and use the code are included. The name of the code is QSONIC. A numerical example is also given to illustrate the output of the program.

  17. Three Dimensional Compressible Turbulent Flow Computations for a Diffusing S-Duct With/Without Vortex Generators

    NASA Technical Reports Server (NTRS)

    Cho, Soo-Yong; Greber, Isaac

    1994-01-01

    Numerical investigations on a diffusing S-duct with/without vortex generators and a straight duct with vortex generators are presented. The investigation consists of solving the full three-dimensional unsteady compressible mass averaged Navier-Stokes equations. An implicit finite volume lower-upper time marching code (RPLUS3D) has been employed and modified. A three-dimensional Baldwin-Lomax turbulence model has been modified in conjunction with the flow physics. A model for the analysis of vortex generators in a fully viscous subsonic internal flow is evaluated. A vortical structure for modeling the shed vortex is used as a source term in the computation domain. The injected vortex paths in the straight duct are compared with the analysis by two kinds of prediction models. The flow structure by the vortex generators are investigated along the duct. Computed results of the flow in a circular diffusing S-duct provide an understanding of the flow structure within a typical engine inlet system. These are compared with the experimental wall static-pressure, static- and total-pressure field, and secondary velocity profiles. Additionally, boundary layer thickness, skin friction values, and velocity profiles in wall coordinates are presented. In order to investigate the effect of vortex generators, various vortex strengths are examined in this study. The total-pressure recovery and distortion coefficients are obtained at the exit of the S-duct. The numerical results clearly depict the interaction between the low velocity flow by the flow separation and the injected vortices.

  18. Three-dimensional segmentation of the tumor in computed tomographic images of neuroblastoma.

    PubMed

    Deglint, Hanford J; Rangayyan, Rangaraj M; Ayres, Fábio J; Boag, Graham S; Zuffo, Marcelo K

    2007-09-01

    Segmentation of the tumor in neuroblastoma is complicated by the fact that the mass is almost always heterogeneous in nature; furthermore, viable tumor, necrosis, and normal tissue are often intermixed. Tumor definition and diagnosis require the analysis of the spatial distribution and Hounsfield unit (HU) values of voxels in computed tomography (CT) images, coupled with a knowledge of normal anatomy. Segmentation and analysis of the tissue composition of the tumor can assist in quantitative assessment of the response to therapy and in the planning of the delayed surgery for resection of the tumor. We propose methods to achieve 3-dimensional segmentation of the neuroblastic tumor. In our scheme, some of the normal structures expected in abdominal CT images are delineated and removed from further consideration; the remaining parts of the image volume are then examined for tumor mass. Mathematical morphology, fuzzy connectivity, and other image processing tools are deployed for this purpose. Expert knowledge provided by a radiologist in the form of the expected structures and their shapes, HU values, and radiological characteristics are incorporated into the segmentation algorithm. In this preliminary study, the methods were tested with 10 CT exams of four cases from the Alberta Children's Hospital. False-negative error rates of less than 12% were obtained in eight of 10 exams; however, seven of the exams had false-positive error rates of more than 20% with respect to manual segmentation of the tumor by a radiologist.

  19. Computational identification of RNA functional determinants by three-dimensional quantitative structure–activity relationships

    PubMed Central

    Blanchet, Marc-Frédérick; St-Onge, Karine; Lisi, Véronique; Robitaille, Julie; Hamel, Sylvie; Major, François

    2014-01-01

    Anti-infection drugs target vital functions of infectious agents, including their ribosome and other essential non-coding RNAs. One of the reasons infectious agents become resistant to drugs is due to mutations that eliminate drug-binding affinity while maintaining vital elements. Identifying these elements is based on the determination of viable and lethal mutants and associated structures. However, determining the structure of enough mutants at high resolution is not always possible. Here, we introduce a new computational method, MC-3DQSAR, to determine the vital elements of target RNA structure from mutagenesis and available high-resolution data. We applied the method to further characterize the structural determinants of the bacterial 23S ribosomal RNA sarcin–ricin loop (SRL), as well as those of the lead-activated and hammerhead ribozymes. The method was accurate in confirming experimentally determined essential structural elements and predicting the viability of new SRL variants, which were either observed in bacteria or validated in bacterial growth assays. Our results indicate that MC-3DQSAR could be used systematically to evaluate the drug-target potentials of any RNA sites using current high-resolution structural data. PMID:25200082

  20. Three-dimensional segmentation of the tumor mass in computed tomographic images of neuroblastoma

    NASA Astrophysics Data System (ADS)

    Deglint, Hanford J.; Rangayyan, Rangaraj M.; Boag, Graham S.

    2004-05-01

    Tumor definition and diagnosis require the analysis of the spatial distribution and Hounsfield unit (HU) values of voxels in computed tomography (CT) images, coupled with a knowledge of normal anatomy. Segmentation of the tumor in neuroblastoma is complicated by the fact that the mass is almost always heterogeneous in nature; furthermore, viable tumor, necrosis, fibrosis, and normal tissue are often intermixed. Rather than attempt to separate these tissue types into distinct regions, we propose to explore methods to delineate the normal structures expected in abdominal CT images, remove them from further consideration, and examine the remaining parts of the images for the tumor mass. We explore the use of fuzzy connectivity for this purpose. Expert knowledge provided by the radiologist in the form of the expected structures and their shapes, HU values, and radiological characteristics are also incorporated in the segmentation algorithm. Segmentation and analysis of the tissue composition of the tumor can assist in quantitative assessment of the response to chemotherapy and in the planning of delayed surgery for resection of the tumor. The performance of the algorithm is evaluated using cases acquired from the Alberta Children's Hospital.

  1. Three-dimensional Computational Simulation and In-vitro Experiments for Assessing Radiocephalic Wrist Arteriovenous Fistulas

    NASA Astrophysics Data System (ADS)

    Song, Ryungeun; Park, Sun Cheol; Kim, Hyun Kyu; Lee, Jinkee

    2016-11-01

    A radio-cephalic arteriovenous fistula (RC-AVF) is the best choice for achieving vascular access (VA) for hemodialysis, but this AVF has high rates of early failure depending on the vessel condition. The high wall shear stress (WSS) contributes to VA failures due to plaque rupture, thrombosis, etc. Thus, we have used a low-Re k- ɛ turbulence based CFD model combined with an in-vitro experimental approach to evaluate the WSS distribution and to minimize its effects under several conditions. The properties considered in this study were non-Newtonian flow characteristics, complete cardiac pulse cycle, and distention of blood vessels. The computational domain was designed for arteriovenous end-to-side anastomosis based on anastomosis angles of 45°, 90°, and 135°. For experiment the digital domains were converted into 3D artificial RC-AVF via poly(dimethylsiloxame) (PDMS) and 3D printing technology. The micro-particle image velocimetry (μ-PIV) was used to measure the velocity field within the artificial blood vessel. The results showed that the largest anastomosis angle (135°) resulted in lower WSS, which would help reduce AVF failures. This research would provide the future possibility of using the proposed method to reduce in-vivo AVF failure for various conditions in each patient.

  2. Consequences of fiducial marker error on three-dimensional computer animation of the temporomandibular joint

    NASA Astrophysics Data System (ADS)

    Leader, J. Ken, III; Boston, J. Robert; Rudy, Thomas E.; Greco, Carol M.; Zaki, Hussein S.

    2001-05-01

    Jaw motion has been used to diagnose jaw pain patients, and we have developed a 3D computer animation technique to study jaw motion. A customized dental clutch was worn during motion, and its consistent and rigid placement was a concern. The experimental protocol involved mandibular movements (vertical opening) and MR imaging. The clutch contained three motion markers used to collect kinematic data and four MR markers used as fiducial markers in the MR images. Fiducial marker misplacement was mimicked by analytically perturbing the position of the MR markers +/- 2, +/- 4, and +/- 6 degrees in the three anatomical planes. The percent difference between the original and perturbed MR marker position was calculated for kinematic parameters. The maximum difference across all perturbations for axial rotation, coronal rotation, sagittal rotation, axial translation, coronal translation, and sagittal translation were 176.85%, 191.84%, 0.64%, 9.76%, 80.75%, and 8.30%, respectively, for perturbing all MR markers, and 86.47%, 93.44%, 0.23%, 7.08%, 42.64%, and 13.64%, respectively, for perturbing one MR marker. The parameters representing movement in the sagittal plane, the dominant plane in vertical opening, were determined to be reasonably robust, while secondary movements in the axial and coronal planes were not considered robust.

  3. Three-dimensional computer-aided human factors engineering analysis of a grafting robot.

    PubMed

    Chiu, Y C; Chen, S; Wu, G J; Lin, Y H

    2012-07-01

    The objective of this research was to conduct a human factors engineering analysis of a grafting robot design using computer-aided 3D simulation technology. A prototype tubing-type grafting robot for fruits and vegetables was the subject of a series of case studies. To facilitate the incorporation of human models into the operating environment of the grafting robot, I-DEAS graphic software was applied to establish individual models of the grafting robot in line with Jack ergonomic analysis. Six human models (95th percentile, 50th percentile, and 5th percentile by height for both males and females) were employed to simulate the operating conditions and working postures in a real operating environment. The lower back and upper limb stresses of the operators were analyzed using the lower back analysis (LBA) and rapid upper limb assessment (RULA) functions in Jack. The experimental results showed that if a leg space is introduced under the robot, the operator can sit closer to the robot, which reduces the operator's level of lower back and upper limbs stress. The proper environmental layout for Taiwanese operators for minimum levels of lower back and upper limb stress are to set the grafting operation at 23.2 cm away from the operator at a height of 85 cm and with 45 cm between the rootstock and scion units.

  4. Three-dimensional microstructure of human alveolar trabecular bone: a micro-computed tomography study

    PubMed Central

    2017-01-01

    Purpose The microstructural characteristics of trabecular bone were identified using micro-computed tomography (micro-CT), in order to develop a potential strategy for implant surface improvement to facilitate osseointegration. Methods Alveolar bone specimens from the cadavers of 30 humans were scanned by high-resolution micro-CT and reconstructed. Volumes of interest chosen within the jaw were classified according to Hounsfield units into 4 bone quality categories. Several structural parameters were measured and statistically analyzed. Results Alveolar bone specimens with D1 bone quality had significantly higher values for all structural parameters than the other bone quality categories, except for trabecular thickness (Tb.Th). The percentage of bone volume, trabecular separation (Tb.Sp), and trabecular number (Tb.N) varied significantly among bone quality categories. Tb.Sp varied markedly across the bone quality categories (D1: 0.59±0.22 mm, D4: 1.20±0.48 mm), whereas Tb.Th had similar values (D1: 0.30±0.08 mm, D4: 0.22±0.05 mm). Conclusions Bone quality depended on Tb.Sp and number—that is, endosteal space architecture—rather than bone surface and Tb.Th. Regardless of bone quality, Tb.Th showed little variation. These factors should be taken into account when developing individualized implant surface topographies. PMID:28261521

  5. Three-dimensional analysis of deciduous maxillary anterior teeth using cone-beam computed tomography.

    PubMed

    Jung, M-S; Lee, S-P; Kim, G-T; Choi, S-C; Park, J-H; Kim, J-W

    2012-03-01

    The recent introduction of cone-beam computed tomography (CBCT) into the medical field has allowed the nondestructive investigation of internal structures at relatively low cost and radiation exposure. The accuracy of CBCT in both two and three dimensions has been demonstrated, and CBCT has been used successfully for craniofacial anatomy. Knowing the anatomical structure of deciduous teeth is essential for clinical dentistry. However, the root structure of deciduous teeth is rarely reported because of the scarcity of intact deciduous teeth without root resorption. The aim of this study was to evaluate the intact root form of deciduous teeth using CBCT. Data from 38 young children was analyzed using an image-analyzing program. The degree of buccal dilacerations was 26.3° for deciduous maxillary central incisors (DMA), 16.5° for deciduous maxillary lateral incisors (DMB), and 17.5° for deciduous maxillary canines (DMC) in about half of the root length. The crown-to-root ratios were 0.52 for DMA, 0.48 for DMB, and 0.52 for DMC. These data will be helpful for understanding the development of dentition, and for clinical dentistry.

  6. Cephalometric Angular Measurements of the Mandible Using Three-Dimensional Computed Tomography Scans in Koreans

    PubMed Central

    Kim, Yong Hyun; Kang, Seok Joo

    2016-01-01

    Background We conducted this study to analyze the values of the key cephalometric angular measurements of the mandible using 3-dimensional (3D) computed tomography scans. Methods In the 106 enrolled patients, a 3D cephalometric analysis was performed to measure the angular variables of the mandible. These values were compared between the two sides and between the two sexes. Results The frontal measurements revealed that the mandibular body curve angle was larger on the left (Lt) side (right [Rt], 141.24±7.54; Lt, 142.68±6.94; P=0.002) and the gonial angle was larger on the right side (Rt, 134.37±8.44; Lt, 131.54±7.14; P<0.001). The sagittal measurements showed that the gonial angle was larger on the right side (Rt, 134.37±8.44; Lt, 131.54±7.14; P>0.05). Further, the transverse measurements revealed that the mandibular body curve angle was larger on the right side (Rt, 140.28±7.05; Lt, 137.56±6.23; P<0.001). Conclusions These results provide an average of the mandibular angular measurements for the Korean population, establishing a standard for determining surgical patient groups and outcome evaluations in the field of mandible contour surgery. PMID:26848443

  7. Morphological study of subaxial cervical pedicles by using three-dimensional computed tomography reconstruction image.

    PubMed

    Wasinpongwanich, Kanthika; Paholpak, Permsak; Tuamsuk, Panya; Sirichativapee, Winai; Wisanuyotin, Taweechok; Kosuwon, Weerachai; Jeeravipoolvarn, Polasak

    2014-01-01

    Malpositioning of cervical screws risks neurovascular injury. A cervical screw fixation system can provide proper rigidity, alignment correction, and high rates of fusion afforded by high pullout biomechanical strength. The objective is to assess the dimensions and axis of the C3-C7 cervical pedicles. A 1-mm slice thickness computed tomography (CT) scan of the cervical spine of 30 patients (15 males, 15 females) were analyzed and reconstructed in three-dimensions using Mimics(®) 10.01 software. We measured pedicle axis length (PAL), pedicle and lateral mass length (PL-LM), pedicle length (PL), outer pedicle width (OPW), and pedicle transverse angle (PTA) from the axial image and outer pedicle height (OPH) and pedicle sagittal angle (PSA) from the sagittal image. The OPH and OPW at all subaxial cervical spines were suitable for insertion of 3.5 mm cervical pedicle screws. PSA was directed cranially at C3 to C5 (13.84, 7.09, and 2.71) and directed caudally at C6 and C7 (-4.55, -6.94). PTA was greatest at C5 and smallest at C7. The respective difference between the left and right side for nearly all parameters was not statistically significant (except for C6 PL and C7 OPH). Females had a significantly smaller OPH and OPW than males at nearly all levels. The PTA was not significantly different between the sexes. Cervical pedicle screw fixation in the Thai population can be safely performed and guidelines for insertion at each vertebra documented. Appropriate preoperative planning is necessary to achieve safe and accurate placement of the screws.

  8. Three-dimensional electromagnetic modeling and inversion on massively parallel computers

    SciTech Connect

    Newman, G.A.; Alumbaugh, D.L.

    1996-03-01

    This report has demonstrated techniques that can be used to construct solutions to the 3-D electromagnetic inverse problem using full wave equation modeling. To this point great progress has been made in developing an inverse solution using the method of conjugate gradients which employs a 3-D finite difference solver to construct model sensitivities and predicted data. The forward modeling code has been developed to incorporate absorbing boundary conditions for high frequency solutions (radar), as well as complex electrical properties, including electrical conductivity, dielectric permittivity and magnetic permeability. In addition both forward and inverse codes have been ported to a massively parallel computer architecture which allows for more realistic solutions that can be achieved with serial machines. While the inversion code has been demonstrated on field data collected at the Richmond field site, techniques for appraising the quality of the reconstructions still need to be developed. Here it is suggested that rather than employing direct matrix inversion to construct the model covariance matrix which would be impossible because of the size of the problem, one can linearize about the 3-D model achieved in the inverse and use Monte-Carlo simulations to construct it. Using these appraisal and construction tools, it is now necessary to demonstrate 3-D inversion for a variety of EM data sets that span the frequency range from induction sounding to radar: below 100 kHz to 100 MHz. Appraised 3-D images of the earth`s electrical properties can provide researchers opportunities to infer the flow paths, flow rates and perhaps the chemistry of fluids in geologic mediums. It also offers a means to study the frequency dependence behavior of the properties in situ. This is of significant relevance to the Department of Energy, paramount to characterizing and monitoring of environmental waste sites and oil and gas exploration.

  9. Particle-induced osteolysis in three-dimensional micro-computed tomography.

    PubMed

    Wedemeyer, Christian; Xu, Jie; Neuerburg, Carl; Landgraeber, Stefan; Malyar, Nasser M; von Knoch, Fabian; Gosheger, Georg; von Knoch, Marius; Löer, Franz; Saxler, Guido

    2007-11-01

    Small-animal models are useful for the in vivo study of particle-induced osteolysis, the most frequent cause of aseptic loosening after total joint replacement. Microstructural changes associated with particle-induced osteolysis have been extensively explored using two-dimensional (2D) techniques. However, relatively little is known regarding the 3D dynamic microstructure of particle-induced osteolysis. Therefore, we tested micro-computed tomography (micro-CT) as a novel tool for 3D analysis of wear debris-mediated osteolysis in a small-animal model of particle-induced osteolysis. The murine calvarial model based on polyethylene particles was utilized in 14 C57BL/J6 mice randomly divided into two groups. Group 1 received sham surgery, and group 2 was treated with polyethylene particles. We performed 3D micro-CT analysis and histological assessment. Various bone morphometric parameters were assessed. Regression was used to examine the relation between the results achieved by the two methods. Micro-CT analysis provides a fully automated means to quantify bone destruction in a mouse model of particle-induced osteolysis. This method revealed that the osteolytic lesions in calvaria in the experimental group were affected irregularly compared to the rather even distribution of osteolysis in the control group. This is an observation which would have been missed if histomorphometric analysis only had been performed, leading to false assessment of the actual situation. These irregularities seen by micro-CT analysis provide new insight into individual bone changes which might otherwise be overlooked by histological analysis and can be used as baseline information on which future studies can be designed.

  10. Three-dimensional computation of drift Alfvén turbulence

    NASA Astrophysics Data System (ADS)

    Scott, B.

    1997-10-01

    A transcollisional, electromagnetic fluid model, incorporating the parallel heat flux as a dependent variable, is constructed to treat electron drift turbulence in the regime of tokamak edge plasmas at the L - H transition. The resulting turbulence is very sensitive to the plasma beta throughout this regime, with the scaling with rising beta produced by the effect of magnetic induction to slow the Alfvénic parallel electron dynamics and thereby leave the turbulence in a more robust, non-adiabatic state. Magnetic flutter and curvature have a minor qualitative effect on the turbulence mode structure and on the beta scaling, even when their quantitative effect is strong. Transport by magnetic flutter is small compared to that by the 0741-3335/39/10/010/img1 flow eddies. Fluctuation statistics show that while the turbulence shows no coherent structure, it is coupled strongly enough so that neither density nor temperature fluctuations behave as passive scalars. Both profile gradients drive the turbulence, with the total thermal energy transport varying only weakly with the gradient ratio, 0741-3335/39/10/010/img2. Scaling with magnetic shear is pronounced, with stronger shear leading to lower drive levels. Scaling with either collision frequency or magnetic curvature is weak, consistent with their weak qualitative effect. The result is that electron drift turbulence at L - H transition edge parameters is drift Alfvén turbulence, with both ballooning and resistivity in a clear secondary role. The contents of the drift Alfvén model will form a significant part of any useful first-principles computation of tokamak edge turbulence.

  11. High-resolution three-dimensional computer simulation of hominid cranial mechanics.

    PubMed

    Wroe, Stephen; Moreno, Karen; Clausen, Philip; McHenry, Colin; Curnoe, Darren

    2007-10-01

    In vivo data demonstrates that strain is not distributed uniformly on the surface of the primate skull during feeding. However, in vivo studies are unable to identify or track changes in stress and strain throughout the whole structure. Finite element (FE) analysis, a powerful engineering tool long used to predict the performance of man-made devices, has the capacity to track stress/strain in three dimensions (3-D) and, despite the time-consuming nature of model generation, FE has become an increasingly popular analytical device among biomechanists. Here, we apply the finite element method using sophisticated computer models to examine whether 3-D stress and strain distributions are nonuniform throughout the primate skull, as has been strongly suggested by 2-D in vivo strain analyses. Our simulations document steep internal stress/strain gradients, using models comprising up to three million tetrahedral finite elements and 3-D reconstructions of jaw adducting musculature with both cranium and mandible in correct anatomical position. Results are in broad concurrence with the suggestion that few regions of the hominid cranium are clearly optimized for routine feeding and also show that external stress/strain does not necessarily reflect internal distributions. Findings further suggest that the complex heterogeneity of bone in the skull may act to dissipate stress, but that consequently higher strain must be offset by additional strain energy. We hypothesize that, despite energetic costs, this system may lend adaptive advantage through enhancing the organism's ability to modify its behavior before reaching catastrophic failure in bony or dental structures.

  12. A spectral formalism for computing three-dimensional deformations due to surface loads. 2: Present-day glacial isostatic adjustment

    NASA Technical Reports Server (NTRS)

    Mitrovica, J. X.; Davis, J. L.; Shapiro, I. I.

    1994-01-01

    Using a spherically symmetric, self-gravitating, linear viscoelastic Earth model, we predict present-day three-dimensional surface deformation rates and baseline evolutions arising as a consequence of the late Pleistocene glacial cycles. In general, we use realistic models for the space-time geometry of the final late Pleistocene deglaciation event and incorporate a gravitationally self-consistent ocean meltwater redistribution. The predictions of horizontal velocity presented differ significantly, in both their amplitude and their spatial variation, from those presented in earlier analysis of others which adopted simplified models of both the late Pleistocene ice history and the Earth rheology. An important characteristic of our predicted velocity fields is that the melting of the Laurentide ice sheet over Canada is capable of contributing appreciably to the adjustment in Europe. The sensitivity of the predictions to variations in mantle rheology is investigated by considering a number of different Earth models, and by computing appropriate Frechet kernels. These calculations suggest that the sensitivity of the deformations to the Earth's rheology is significant and strongly dependent on the location of the site relative to the ancient ice sheet. The effects on the predictions of three-dimensional deformation rates of altering the ice history or adopting approximate models for the ocean meltwater redistribution have also been considered and found to be important (the former especially so). Finally, for a suite of Earth models we provide predictions of the velocity of a number of baselines in North America and Europe. We find that, in general, both radial and tangential motions contribute significantly to baseline length changes, and that these contributions are a strong function of the Earth model. We have, furthermore, found a set of Earth models which, together with the ICE-3G deglaciation chronology, produce predictions of baseline length changes that are

  13. Three-Dimensional Analysis of Voids in AM60B Magnesium Tensile Bars Using Computed Tomography Imagery

    SciTech Connect

    Waters, A M

    2001-05-01

    In an effort to increase automobile fuel efficiency as well as decrease the output of harmful greenhouse gases, the automotive industry has recently shown increased interest in cast light metals such as magnesium alloys in an effort to increase weight savings. Currently several magnesium alloys such as AZ91 and AM60B are being used in structural applications for automobiles. However, these magnesium alloys are not as well characterized as other commonly used structural metals such as aluminum. This dissertation presents a methodology to nondestructively quantify damage accumulation due to void behavior in three dimensions in die-cast magnesium AM60B tensile bars as a function of mechanical load. Computed tomography data was acquired after tensile bars were loaded up to and including failure, and analyzed to characterize void behavior as it relates to damage accumulation. Signal and image processing techniques were used along with a cluster labeling routine to nondestructively quantify damage parameters in three dimensions. Void analyses were performed including void volume distribution characterization, nearest neighbor distance calculations, shape parameters, and volumetric renderings of voids in the alloy. The processed CT data was used to generate input files for use in finite element simulations, both two- and three-dimensional. The void analyses revealed that the overwhelming source of failure in each tensile bar was a ring of porosity within each bar, possibly due to a solidification front inherent to the casting process. The measured damage parameters related to void nucleation, growth, and coalescence were shown to contribute significantly to total damage accumulation. Void volume distributions were characterized using a Weibull function, and the spatial distributions of voids were shown to be clustered. Two-dimensional finite element analyses of the tensile bars were used to fine-tune material damage models and a three-dimensional mesh of an extracted

  14. Acceleration of color computer-generated hologram from three-dimensional scenes with texture and depth information

    NASA Astrophysics Data System (ADS)

    Shimobaba, Tomoyoshi; Kakue, Takashi; Ito, Tomoyoshi

    2014-06-01

    We propose acceleration of color computer-generated holograms (CGHs) from three-dimensional (3D) scenes that are expressed as texture (RGB) and depth (D) images. These images are obtained by 3D graphics libraries and RGB-D cameras: for example, OpenGL and Kinect, respectively. We can regard them as two-dimensional (2D) cross-sectional images along the depth direction. The generation of CGHs from the 2D cross-sectional images requires multiple diffraction calculations. If we use convolution-based diffraction such as the angular spectrum method, the diffraction calculation takes a long time and requires large memory usage because the convolution diffraction calculation requires the expansion of the 2D cross-sectional images to avoid the wraparound noise. In this paper, we first describe the acceleration of the diffraction calculation using "Band-limited double-step Fresnel diffraction," which does not require the expansion. Next, we describe color CGH acceleration using color space conversion. In general, color CGHs are generated on RGB color space; however, we need to repeat the same calculation for each color component, so that the computational burden of the color CGH generation increases three-fold, compared with monochrome CGH generation. We can reduce the computational burden by using YCbCr color space because the 2D cross-sectional images on YCbCr color space can be down-sampled without the impairing of the image quality.

  15. Airway space changes after maxillomandibular counterclockwise rotation and mandibular advancement with TMJ Concepts® total joint prostheses: three-dimensional assessment.

    PubMed

    Gonçalves, J R; Gomes, L C R; Vianna, A P; Rodrigues, D B; Gonçalves, D A G; Wolford, L M

    2013-08-01

    This study focused on three-dimensional (3D) airway space changes and stability following simultaneous maxillomandibular counterclockwise rotation, mandibular advancement, and temporomandibular joint (TMJ) reconstruction with custom-made total joint prostheses (TMJ Concepts(®)). Cone beam computed tomography (CBCT) scans of 30 consecutive female patients with irreversibly compromised TMJs were obtained at the following intervals: T1, presurgery; T2, immediately after surgery; and T3, at least 6 months after surgery. The CBCT volumetric datasets were analysed with Dolphin Imaging(®) software to evaluate surgical and postsurgical changes to oropharyngeal airway parameters. The average changes in airway surface area (SA), volume (VOL), and minimum axial area (MAA) were, 179.50 mm(2), 6302.60 mm(3), and 92.23 mm(2), respectively, at the longest follow-up (T3-T1) (P≤0.001). Significant correlations between the amount of mandibular advancement and counterclockwise rotation of the occlusal plane and 3D airway changes were also found (P≤0.01). The results of this investigation showed a significant immediate 3D airway space increase after maxillomandibular counterclockwise rotation and mandibular advancement with TMJ Concepts total joint prostheses, which remained stable over the follow-up period.

  16. Clinical application of a novel computer-aided detection system based on three-dimensional CT images on pulmonary nodule.

    PubMed

    Zeng, Jian-Ye; Ye, Hai-Hong; Yang, Shi-Xiong; Jin, Ren-Chao; Huang, Qi-Liang; Wei, Yong-Chu; Huang, Si-Guang; Wang, Bin-Qiang; Ye, Jia-Zhou; Qin, Jian-Ying

    2015-01-01

    The aim of this study was to investigate the clinical application effects of a novel computer-aided detection (CAD) system based on three-dimensional computed tomography (CT) images on pulmonary nodule. 98 cases with pulmonary nodule (PN) in our hospital from Jun, 2009 to Jun, 2013 were analysed in this study. All cases underwent PN detection both by the simple spiral CT scan and by the computer-aided system based on 3D CT images, respectively. Postoperative pathological results were considered as the "gold standard", for both two checking methods, the diagnostic accuracies for determining benign and malignant PN were calculated. Under simple spiral CT scan method, 63 cases is malignant, including 50 true positive cases and 13 false positive cases from the "gold standard"; 35 cases is benign, 16 true negative case and 19 false negative cases, the Sensitivity 1 (Se1)=0.725, Specificity1 (Sp1)=0.448, Agreement rate1 (Kappa 1)=0.673, J1 (Youden's index 1)=0.173, LR(+)1=1.616, LR(-)1=0.499. Kappa 1=0.673 between the 0.4 and 0.75, has a moderate consistency. Underwent computer-aided detection (CAD) based on 3D CT method, 67cases is malignant, including 62 true positive cases and 7 false positive cases; 31 cases is benign, 24 true negative case and 7 false negative cases, Sensitivity 2 (Se2)=0.899, Specificity2 (Sp2)=0.828, Agreement rate (Kappa 2)=0.877, J2 (Youden's index 2)=0.727, LR(+)2=5.212, LR(-)2=0.123. Kappa 2=0.877 >0.75, has a good consistency. Computer-aided PN detecting system based on 3D CT images has better clinical application value, and can help doctor carry out early diagnosis of lung disease (such as cancer, etc.) through CT images.

  17. Incorporating texture features in a computer-aided breast lesion diagnosis system for automated three-dimensional breast ultrasound.

    PubMed

    Liu, Haixia; Tan, Tao; van Zelst, Jan; Mann, Ritse; Karssemeijer, Nico; Platel, Bram

    2014-07-01

    We investigated the benefits of incorporating texture features into an existing computer-aided diagnosis (CAD) system for classifying benign and malignant lesions in automated three-dimensional breast ultrasound images. The existing system takes into account 11 different features, describing different lesion properties; however, it does not include texture features. In this work, we expand the system by including texture features based on local binary patterns, gray level co-occurrence matrices, and Gabor filters computed from each lesion to be diagnosed. To deal with the resulting large number of features, we proposed a combination of feature-oriented classifiers combining each group of texture features into a single likelihood, resulting in three additional features used for the final classification. The classification was performed using support vector machine classifiers, and the evaluation was done with 10-fold cross validation on a dataset containing 424 lesions (239 benign and 185 malignant lesions). We compared the classification performance of the CAD system with and without texture features. The area under the receiver operating characteristic curve increased from 0.90 to 0.91 after adding texture features ([Formula: see text]).

  18. Effects of using two- versus three-dimensional computational modeling of fluidized beds: Part II, budget analysis

    SciTech Connect

    Xie, Nan; Battaglia, Francine; Pannala, Sreekanth

    2008-01-01

    The partial differential equations for modeling gas-solid flows using computational fluid dynamics are compared for different coordinate systems. The numerical results of 2D and 3D simulations for both cylindrical and rectangular domains are presented in Part I (N. Xie, F. Battaglia, S. Pannala, Effects of using two- versus three-dimensional computational modeling of fluidized beds: Part I, Hydrodynamics (2007-this volume), doi:10.1016/j.powtec.2007.07.005), comparing the hydrodynamic features of a fluidized bed. The individual terms of the governing equations in 2D and 3D simulations with the cylindrical and Cartesian coordinate systems are evaluated in this study through a budget analysis. The additional terms appearing in the 3D equations can be used to explain the discrepancies between 2D and 3D simulations. The values of the additional terms is shown to increase as inlet gas velocity increases. This explains the good agreement between 2D and 3D simulations that is observed for bubbling regimes with low gas velocity, and why the differences between 2D and 3D simulations increases for slugging and turbulent regimes.

  19. Cadaveric and three-dimensional computed tomography study of the morphology of the scapula with reference to reversed shoulder prosthesis

    PubMed Central

    Torrens, Carlos; Corrales, Monica; Gonzalez, Gemma; Solano, Alberto; Cáceres, Enrique

    2008-01-01

    Purpose The purpose of this study is to analyze the morphology of the scapula with reference to the glenoid component implantation in reversed shoulder prosthesis, in order to improve primary fixation of the component. Methods Seventy-three 3-dimensional computed tomography of the scapula and 108 scapular dry specimens were analyzed to determine the anterior and posterior length of the glenoid neck, the angle between the glenoid surface and the upper posterior column of the scapula and the angle between the major craneo-caudal glenoid axis and the base of the coracoid process and the upper posterior column. Results The anterior and posterior length of glenoid neck was classified into two groups named "short-neck" and "long-neck" with significant differences between them. The angle between the glenoid surface and the upper posterior column of the scapula was also classified into two different types: type I (mean 50°–52°) and type II (mean 62,50°–64°), with significant differences between them (p < 0,001). The angle between the major craneo-caudal glenoid axis and the base of the coracoid process averaged 18,25° while the angle with the upper posterior column of the scapula averaged 8°. Conclusion Scapular morphological variability advices for individual adjustments of glenoid component implantation in reversed total shoulder prosthesis. Three-dimensional computed tomography of the scapula constitutes an important tool when planning reversed prostheses implantation. PMID:18847487

  20. Comparison of Scrape-off Layer Turbulence in Alcator C-Mod with Three Dimensional Gyrofluid Computations

    SciTech Connect

    Zweben, S. J.; Scott, B. D.; Terry, J. L.; LaBombard, B.; Hughes, J. W.; Stotler, D. P.

    2009-09-01

    This paper describes quantitative comparisons between turbulence measured in the scrape-off layer (SOL) of Alcator C-Mod [S. Scott, A. Bader, M. Bakhtiari et al., Nucl. Fusion 47, S598 (2007)] and three dimensional computations using electromagnetic gyrofluid equations in a two-dimensional tokamak geometry. These comparisons were made for the outer midplane SOL for a set of inner-wall limited, near-circular Ohmic plasmas. The B field and plasma density were varied to assess gyroradius and collisionality scaling. The poloidal and radial correlation lengths in the experiment and computation agreed to within a factor of 2 and did not vary significantly with either B or density. The radial and poloidal propagation speeds and the frequency spectra and poloidal k-spectra also agreed fairly well. However, the autocorrelation times and relative Da fluctuation levels were higher in the experiment by more than a factor of 2. Possible causes for these disagreements are discussed. 2009 American Institute of Physics.

  1. Incorporating texture features in a computer-aided breast lesion diagnosis system for automated three-dimensional breast ultrasound

    PubMed Central

    Liu, Haixia; Tan, Tao; van Zelst, Jan; Mann, Ritse; Karssemeijer, Nico; Platel, Bram

    2014-01-01

    Abstract. We investigated the benefits of incorporating texture features into an existing computer-aided diagnosis (CAD) system for classifying benign and malignant lesions in automated three-dimensional breast ultrasound images. The existing system takes into account 11 different features, describing different lesion properties; however, it does not include texture features. In this work, we expand the system by including texture features based on local binary patterns, gray level co-occurrence matrices, and Gabor filters computed from each lesion to be diagnosed. To deal with the resulting large number of features, we proposed a combination of feature-oriented classifiers combining each group of texture features into a single likelihood, resulting in three additional features used for the final classification. The classification was performed using support vector machine classifiers, and the evaluation was done with 10-fold cross validation on a dataset containing 424 lesions (239 benign and 185 malignant lesions). We compared the classification performance of the CAD system with and without texture features. The area under the receiver operating characteristic curve increased from 0.90 to 0.91 after adding texture features (p<0.001). PMID:26158036

  2. Computer prediction of three-dimensional potential flow fields in which aircraft propellers operate. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Jumper, S. J.

    1982-01-01

    A computer program was developed to calculate the three dimensional, steady, incompressible, inviscid, irrotational flow field at the propeller plane (propeller removed) located upstream of an arbitrary airframe geometry. The program uses a horseshoe vortex of known strength to model the wing. All other airframe surfaces are modeled by a network source panels of unknown strength which is exposed to a uniform free stream and the wing-induced velocity field. By satisfying boundary conditions on each panel (the Neumann problem), relaxed boundary conditions being used on certain panels to simulate inlet inflow, the source strengths are determined. From the known source and wing vortex strengths, the resulting velocity fields on the airframe surface and at the propeller plane are obtained. All program equations are derived in detail, and a brief description of the program structure is presented. A user's manual which fully documents the program is cited. Computer predictions of the flow on the surface of a sphere and at a propeller plane upstream of the sphere are compared with the exact mathematical solutions. Agreement is good, and correct program operation is verified.

  3. Proteus three-dimensional Navier-Stokes computer code, version 1.0. Volume 2: User's guide

    NASA Technical Reports Server (NTRS)

    Towne, Charles E.; Schwab, John R.; Bui, Trong T.

    1993-01-01

    A computer code called Proteus 3D was developed to solve the three-dimensional, Reynolds-averaged, unsteady compressible Navier-Stokes equations in strong conservation law form. The objective in this effort was to develop a code for aerospace propulsion applications that is easy to use and easy to modify. Code readability, modularity, and documentation were emphasized. The governing equations are solved in generalized nonorthogonal body-fitted coordinates, by marching in time using a fully-coupled ADI solution procedure. The boundary conditions are treated implicitly. All terms, including the diffusion terms, are linearized using second-order Taylor series expansions. Turbulence is modeled using either an algebraic or two-equation eddy viscosity model. The thin-layer or Euler equations may also be solved. The energy equation may be eliminated by the assumption of constant total enthalpy. Explicit and implicit artificial viscosity may be used. Several time step options are available for convergence acceleration. The documentation is divided into three volumes. This User's Guide describes the program's features, the input and output, the procedure for setting up initial conditions, the computer resource requirements, the diagnostic messages that may be generated, the job control language used to run the program, and several test cases.

  4. Fast computation of Fresnel diffraction field of a three-dimensional object for a pixelated optical device.

    PubMed

    Esmer, G Bora

    2013-01-01

    In this paper, a fast algorithm is proposed for accurate calculation of the scalar optical diffraction on a pixelated optical device used in the reconstruction process from a three-dimensional object that is formed by scattered sample points over the space. In computer-generated holography, fast and accurate calculation of the diffraction field is an important and a challenging problem. Therefore, several fast algorithms can be found in the literature. The accuracy of the calculations can be determined by the signal processing techniques and the numerical methods used in the calculation of diffraction fields. Furthermore, the quality of reconstructed objects can be affected by the properties of optical devices employed in the reconstruction process. For instance, the pixelated structure of those devices has a significant effect on the reconstruction process. Therefore, the pixelated structure of the display device has to be taken into account. Furthermore, fast calculation of the diffraction pattern can be a bottleneck in dynamic holographic content generation. As a solution to the problems, we propose a fast and accurate algorithm based on a precomputed one-dimensional kernel and scaling of that kernel for the computation of the diffraction pattern for a pixelated display.

  5. Three-dimensional image reconstruction of an anorectal malformation with multidetector-row helical computed tomography technology.

    PubMed

    Watanabe, Yoshio; Ando, Hisami; Seo, Takahiko; Kaneko, Kentaro; Katsuno, Shinsuke; Shinohara, Tsuyoshi; Mori, Kensaku; Toriwaki, Junichiro

    2003-05-01

    The presentation of the surgical anatomy of anorectal malformation by standard anatomical figures is not suitable for individual anorectoplasty. It is essential to understand the anatomy of the pelvic muscle (striated muscle complex: SMC) including the external anal sphincter and their three-dimensional (3D) configuration in each patient. Thus, we studied the SMC three-dimensionally with multidetector-row helical computed tomography (MRH-CT) preoperatively, and evaluated its usefulness. Fourteen patients with anorectal malformations before anorectoplasty (types: high n=6, intermediate n=2, low n=6) and two patients without anorectal malformations as controls (total: male n=8, female n=8) were investigated. An image of pelvic region was prepared with a slice thickness of 0.5 mm and a reconstruction pitch of 0.5 mm. A 3D reconstruction on a conventional personal computer (PC) was made with a volume rendering method, and assisted by our own software. The SMC was analyzed with three modified modes of 3D reconstruction corresponding to the surrounding tissues. A length of the parasagittal muscle, and both the sagittal and transverse width of the vertical fibers in the SMC at the connection to the parasagittal muscle were measured on a 3D image and then compared among three different types and controls. To eliminate variations in age, a length index was used to allow comparison. The 3D configuration of the SMC was different in every case. The arranged image mode, which displayed the SMC and the pelvic bones simultaneously, enabled to use conventional knowledge in cysto-urethrography. The length of the parasagittal muscle was longest in the high type but the width of the vertical fibers was smallest. Anatomical figures of the SMC including the external anal sphincter were clearly demonstrated on a PC in every anorectal malformation by our program. A 3D reconstruction image provides positional information on the SMC for the body surface and pelvic bone at the same time

  6. GRID3O: Computer program for fast generation of multilevel, three-dimensional boundary-conforming O-type computational grids

    NASA Technical Reports Server (NTRS)

    Dulikravich, D. S.

    1981-01-01

    A fast algorithm was developed for accurately generating boundary-conforming, three-dimensional, consecutively refined computational grids applicable to arbitrary wing-body and axial turbomachinery geometries. The method is based on using an analytic function to generate two-dimensional grids on a number of coaxial axisymmetric surfaces positioned between the centerbody and the outer radial boundary. These grids are of the O-type and are characterized by quasi-orthogonality, geometric periodicity, and an adequate resolution throughout the flow field. Because the built-in nonorthogonal coordinate stretching and shearing cause the grid lines leaving the blade or wing trailing edge to end at downstream infinity, the numerical treatment of the three-dimensional trailing vortex sheets is simplified.

  7. Effect of Bladder Distension on Dose Distribution of Intracavitary Brachytherapy for Cervical Cancer: Three-Dimensional Computed Tomography Plan Evaluation

    SciTech Connect

    Cengiz, Mustafa Guerdalli, Salih; Selek, Ugur; Yildiz, Ferah; Saglam, Yuecel; Ozyar, Enis; Atahan, I. Lale

    2008-02-01

    Purpose: To quantify the effect of bladder volume on the dose distribution during intracavitary brachytherapy for cervical cancer. Methods and Patients: The study was performed on 10 women with cervical cancer who underwent brachytherapy treatment. After insertion of the brachytherapy applicator, the patients were transferred to the computed tomography unit. Two sets of computed tomography slices were taken, including the pelvis, one with an empty bladder and one after the bladder was filled with saline. The target and critical organs were delineated by the radiation oncologist and checked by the expert radiologist. The radiotherapy plan was run on the Plato planning system, version 14.1, to determine the dose distributions, dose-volume histograms, and maximal dose points. The doses and organ volumes were compared with the Wilcoxon signed ranks test on a personal computer using the Statistical Package for Social Sciences, version 11.0, statistical program. Results: No significant difference regarding the dose distribution and target volumes between an empty or full bladder was observed. Bladder fullness significantly affected the dose to the small intestine, rectum, and bladder. The median of maximal doses to the small intestine was significantly greater with an empty bladder (493 vs. 284 cGy). Although dosimetry revealed lower doses for larger volumes of bladder, the median maximal dose to the bladder was significantly greater with a full bladder (993 vs. 925 cGy). The rectal doses were also affected by bladder distension. The median maximal dose was significantly lower in the distended bladder (481vs. 628 cGy). Conclusions: Bladder fullness changed the dose distributions to the bladder, rectum, and small intestine. The clinical importance of these changes is not known and an increase in the use of three-dimensional brachytherapy planning will highlight the answer to this question.

  8. Quadcopter control in three-dimensional space using a noninvasive motor imagery-based brain-computer interface

    NASA Astrophysics Data System (ADS)

    LaFleur, Karl; Cassady, Kaitlin; Doud, Alexander; Shades, Kaleb; Rogin, Eitan; He, Bin

    2013-08-01

    Objective. At the balanced intersection of human and machine adaptation is found the optimally functioning brain-computer interface (BCI). In this study, we report a novel experiment of BCI controlling a robotic quadcopter in three-dimensional (3D) physical space using noninvasive scalp electroencephalogram (EEG) in human subjects. We then quantify the performance of this system using metrics suitable for asynchronous BCI. Lastly, we examine the impact that the operation of a real world device has on subjects' control in comparison to a 2D virtual cursor task. Approach. Five human subjects were trained to modulate their sensorimotor rhythms to control an AR Drone navigating a 3D physical space. Visual feedback was provided via a forward facing camera on the hull of the drone. Main results. Individual subjects were able to accurately acquire up to 90.5% of all valid targets presented while travelling at an average straight-line speed of 0.69 m s-1. Significance. Freely exploring and interacting with the world around us is a crucial element of autonomy that is lost in the context of neurodegenerative disease. Brain-computer interfaces are systems that aim to restore or enhance a user's ability to interact with the environment via a computer and through the use of only thought. We demonstrate for the first time the ability to control a flying robot in 3D physical space using noninvasive scalp recorded EEG in humans. Our work indicates the potential of noninvasive EEG-based BCI systems for accomplish complex control in 3D physical space. The present study may serve as a framework for the investigation of multidimensional noninvasive BCI control in a physical environment using telepresence robotics.

  9. Three-dimensional computer graphics-based ankle morphometry with computerized tomography for total ankle replacement design and positioning.

    PubMed

    Kuo, Chien-Chung; Lu, Hsuan-Lun; Leardini, Alberto; Lu, Tung-Wu; Kuo, Mei-Ying; Hsu, Horng-Chaung

    2014-05-01

    Morphometry of the bones of the ankle joint is important for the design of joint replacements and their surgical implantations. However, very little three-dimensional (3D) data are available and not a single study has addressed the Chinese population. Fifty-eight fresh frozen Chinese cadaveric ankle specimens, 26 females, and 32 males, were CT-scanned in the neutral position and their 3D computer graphics-based models were reconstructed. The 3D morphology of the distal tibia/fibula segment and the full talus was analyzed by measuring 31 parameters, defining the relevant dimensions, areas, and volumes from the models. The measurements were compared statistically between sexes and with previously reported data from Caucasian subjects. The results showed that, within a general similarity of ankle morphology between the current Chinese and previous Caucasian subjects groups, there were significant differences in 9 out of the 31 parameters analyzed. From a quantitative comparison with available prostheses designed for the Caucasian population, few of these designs have both tibial and talar components suitable in dimension for the Chinese population. The current data will be helpful for the sizing, design, and surgical positioning of ankle replacements and for surgical instruments, especially for the Chinese population.

  10. Combining micro computed tomography and three-dimensional registration to evaluate local strains in shape memory scaffolds.

    PubMed

    Bormann, Therese; Schulz, Georg; Deyhle, Hans; Beckmann, Felix; de Wild, Michael; Küffer, Jürg; Münch, Christoph; Hoffmann, Waldemar; Müller, Bert

    2014-02-01

    Appropriate mechanical stimulation of bony tissue enhances osseointegration of load-bearing implants. Uniaxial compression of porous implants locally results in tensile and compressive strains. Their experimental determination is the objective of this study. Selective laser melting is applied to produce open-porous NiTi scaffolds of cubic units. To measure displacement and strain fields within the compressed scaffold, the authors took advantage of synchrotron radiation-based micro computed tomography during temperature increase and non-rigid three-dimensional data registration. Uniaxial scaffold compression of 6% led to local compressive and tensile strains of up to 15%. The experiments validate modeling by means of the finite element method. Increasing the temperature during the tomography experiment from 15 to 37°C at a rate of 4 K h(-1), one can locally identify the phase transition from martensite to austenite. It starts at ≈ 24°C on the scaffolds bottom, proceeds up towards the top and terminates at ≈ 34°C on the periphery of the scaffold. The results allow not only design optimization of the scaffold architecture, but also estimation of maximal displacements before cracks are initiated and of optimized mechanical stimuli around porous metallic load-bearing implants within the physiological temperature range.

  11. The effects of the October 1989 solar proton events on the stratosphere as computed using a three-dimensional model

    NASA Astrophysics Data System (ADS)

    Jackman, Charles H.; Nielsen, J. Eric; Allen, Dale J.; Cerniglia, Mark C.; McPeters, Richard D.; Douglass, Anne R.; Rood, Richard B.

    1993-03-01

    Very large solar proton events (SPEs) occurred from October 19-27, 1989. These SPEs are predicted to produce short-lived increases in HOx and long-lived increases in NOx species, which both can lead to ozone destruction. December 1989 SBUV/2 measurements of upper stratospheric ozone show substantially more ozone depletion in the Northern than in the Southern Hemisphere even though the amount of HOx and NOx produced in both hemispheres should be similar from these SPEs. Our two-dimensional (2D) model simulations predict only a modest interhemispheric difference in the ozone depletion in December caused by the October 1989 SPEs. In an attempt to better understand the interhemispheric difference in the observed ozone depletion, we have used the GSFC three-dimensional (3D) chemistry and transport model to simulate the distribution of NOx and ozone after the SPEs. Our 3D model computations of ozone and NOx behavior for two months after the October 1989 SPEs indicate differences in the constituent behavior in the two hemispheres during the October-November-December 1989 time period which are qualitatively consistent with SBUV/2 ozone observations. These differences are caused by: 1) Substantial mixing of perturbed air in the Southern Hemisphere from the polar region with unperturbed lower latitude air during the November final warming; and 2) Significant confinement of the photochemically perturbed air in the Northern Hemisphere in the winter-time polar vortex.

  12. Computational analysis of a three-dimensional High-Velocity Oxygen-Fuel (HVOF) Thermal Spray torch

    SciTech Connect

    Hassan, B.; Lopez, A.R.; Oberkampf, W.L.

    1995-07-01

    An analysis of a High-Velocity Oxygen-Fuel Thermal Spray torch is presented using computational fluid dynamics (CFD). Three-dimensional CFD results are presented for a curved aircap used for coating interior surfaces such as engine cylinder bores. The device analyzed is similar to the Metco Diamond Jet Rotating Wire torch, but wire feed is not simulated. To the authors` knowledge, these are the first published 3-D results of a thermal spray device. The feed gases are injected through an axisymmetric nozzle into the curved aircap. Argon is injected through the center of the nozzle. Pre-mixed propylene and oxygen are introduced from an annulus in the nozzle, while cooling air is injected between the nozzle and the interior wall of the aircap. The combustion process is modeled assuming instantaneous chemistry. A standard, two-equation, K-{var_epsilon} turbulence model is employed for the turbulent flow field. An implicit, iterative, finite volume numerical technique is used to solve the coupled conservation of mass, momentum, and energy equations for the gas in a sequential manner. Flow fields inside and outside the aircap are presented and discussed.

  13. Exact transparent boundary condition for the three-dimensional Schrödinger equation in a rectangular cuboid computational domain.

    PubMed

    Feshchenko, R M; Popov, A V

    2013-11-01

    We report an exact transparent boundary condition (TBC) on the surface of a rectangular cuboid for the three-dimensional (3D) time-dependent Schrödinger equation. It is obtained as a generalization of the well-known TBC for the 1D Schrödinger equation and of the exact TBC in the rectangular domain for the 3D parabolic wave equation, which we reported earlier. Like all other TBCs, it is nonlocal in time domain and relates the boundary transverse derivative of the wave function at any given time to the boundary values of the same wave function at all preceding times. We develop a discretization of this boundary condition for the implicit Crank-Nicolson finite difference scheme. Several numerical experiments demonstrate evolution of the wave function in free space as well as propagation through a number of 3D spherically symmetrical and asymmetrical barriers, and, finally, scattering off an asymmetrical 3D potential. The proposed boundary condition is simple and robust, and can be useful in computational quantum mechanics when an accurate numerical solution of the 3D Schrödinger equation is required.

  14. Proteus three-dimensional Navier-Stokes computer code, version 1.0. Volume 3: Programmer's reference

    NASA Technical Reports Server (NTRS)

    Towne, Charles E.; Schwab, John R.; Bui, Trong T.

    1993-01-01

    A computer code called Proteus 3D was developed to solve the three-dimensional, Reynolds-averaged, unsteady compressible Navier-Stokes equations in strong conservation law form. The objective in this effort was to develop a code for aerospace propulsion applications that is easy to use and easy to modify. Code readability, modularity, and documentation were emphasized. The governing equations are solved in generalized nonorthogonal body fitted coordinates, by marching in time using a fully-coupled ADI solution procedure. The boundary conditions are treated implicitly. All terms, including the diffusion terms, are linearized using second-order Taylor series expansions. Turbulence is modeled using either an algebraic or two-equation eddy viscosity model. The thin-layer or Euler equations may also be solved. The energy equation may be eliminated by the assumption of constant total enthalpy. Explicit and implicit artificial viscosity may be used. Several time step options are available for convergence acceleration. The documentation is divided into three volumes. The Programmer's Reference contains detailed information useful when modifying the program. The program structure, the Fortran variables stored in common blocks, and the details of each subprogram are described.

  15. PORTHOS - A computer code for solving general three-dimensional, time-dependent two-fluid equations

    SciTech Connect

    Chan, R.K.C.; Masiello, P.J.; Srikantiah, G.S.

    1987-01-01

    PORTHOS is a computer code for calculating three-dimensional steady-state or time dependent two-phase flow in porous or non-porous media. It was developed with the initial goal of simulating two-phase flows in steam generators of PWR nuclear power plants. However, the modular code design and the generality of approach allow application to a wide variety of problems in single phase or two-phase flow. The present method employs a finite difference technique to solve the complete set of two-fluid equations, i.e., the ''six-equation'' model which includes tow mass conservation equations, two momentum equations, two energy equations, as well as constitutive equations to effect closure of the system. The use of volume porosity and surface permeability allows the treatment of complex geometry. This paper describes the mathematical basis, the numerical solution procedure employed, and the results of comparisons with two sources of experimental data: the 8MW FRIGG loop experiment and the Electricite de France (EdF) Bugey 4 steam generator test. Calculations of the FRIGG experiment by PORTHOS, in terms of void fraction distribution, are in good agreement with measurements. Verification against the EdF data is also quite satisfactory.

  16. Proteus three-dimensional Navier-Stokes computer code, version 1.0. Volume 1: Analysis description

    NASA Technical Reports Server (NTRS)

    Towne, Charles E.; Schwab, John R.; Bui, Trong T.

    1993-01-01

    A computer code called Proteus 3D has been developed to solve the three dimensional, Reynolds averaged, unsteady compressible Navier-Stokes equations in strong conservation law form. The objective in this effort has been to develop a code for aerospace propulsion applications that is easy to use and easy to modify. Code readability, modularity, and documentation have been emphasized. The governing equations are solved in generalized non-orthogonal body-fitted coordinates by marching in time using a fully-coupled ADI solution procedure. The boundary conditions are treated implicitly. All terms, including the diffusion terms, are linearized using second-order Taylor series expansions. Turbulence is modeled using either an algebraic or two-equation eddy viscosity model. The thin-layer or Euler equations may also be solved. The energy equation may be eliminated by the assumption of constant total enthalpy. Explicit and implicit artificial viscosity may be used. Several time step options are available for convergence acceleration. The documentation is divided into three volumes. This is the Analysis Description, and presents the equations and solution procedure. It describes in detail the governing equations, the turbulence model, the linearization of the equations and boundary conditions, the time and space differencing formulas, the ADI solution procedure, and the artificial viscosity models.

  17. Failure analysis of fuel cell electrodes using three-dimensional multi-length scale X-ray computed tomography

    NASA Astrophysics Data System (ADS)

    Pokhrel, A.; El Hannach, M.; Orfino, F. P.; Dutta, M.; Kjeang, E.

    2016-10-01

    X-ray computed tomography (XCT), a non-destructive technique, is proposed for three-dimensional, multi-length scale characterization of complex failure modes in fuel cell electrodes. Comparative tomography data sets are acquired for a conditioned beginning of life (BOL) and a degraded end of life (EOL) membrane electrode assembly subjected to cathode degradation by voltage cycling. Micro length scale analysis shows a five-fold increase in crack size and 57% thickness reduction in the EOL cathode catalyst layer, indicating widespread action of carbon corrosion. Complementary nano length scale analysis shows a significant reduction in porosity, increased pore size, and dramatically reduced effective diffusivity within the remaining porous structure of the catalyst layer at EOL. Collapsing of the structure is evident from the combination of thinning and reduced porosity, as uniquely determined by the multi-length scale approach. Additionally, a novel image processing based technique developed for nano scale segregation of pore, ionomer, and Pt/C dominated voxels shows an increase in ionomer volume fraction, Pt/C agglomerates, and severe carbon corrosion at the catalyst layer/membrane interface at EOL. In summary, XCT based multi-length scale analysis enables detailed information needed for comprehensive understanding of the complex failure modes observed in fuel cell electrodes.

  18. A Systematic Review of Protocols for the Three-Dimensional Morphologic Assessment of Abdominal Aortic Aneurysms Using Computed Tomographic Angiography

    SciTech Connect

    Ghatwary, Tamer M. H.; Patterson, Benjamin O.; Karthikesalingam, Alan; Hinchliffe, Robert J.; Loftus, Ian M.; Morgan, Robert; Thompson, Matt M.; Holt, Peter J. E.

    2013-02-15

    The morphology of infrarenal abdominal aortic aneurysms (AAAs) directly influences the perioperative outcome and long-term durability of endovascular aneurysm repair. A variety of methods have been proposed for the characterization of AAA morphology using reconstructed three-dimensional (3D) computed tomography (CT) images. At present, there is lack of consensus as to which of these methods is most applicable to clinical practice or research. The purpose of this review was to evaluate existing protocols that used 3D CT images in the assessment of various aspects of AAA morphology. An electronic search was performed, from January 1996 to the end of October 2010, using the Embase and Medline databases. The literature review conformed to PRISMA statement standards. The literature search identified 604 articles, of which 31 studies met inclusion criteria. Only 15 of 31 studies objectively assessed reproducibility. Existing published protocols were insufficient to define a single evidence-based methodology for preoperative assessment of AAA morphology. Further development and expert consensus are required to establish a standardized and validated protocol to determine precisely how morphology relates to outcomes after endovascular aneurysm repair.

  19. Regularity criterion for solutions of the three-dimensional Cahn-Hilliard-Navier-Stokes equations and associated computations

    NASA Astrophysics Data System (ADS)

    Gibbon, John D.; Pal, Nairita; Gupta, Anupam; Pandit, Rahul

    2016-12-01

    We consider the three-dimensional (3D) Cahn-Hilliard equations coupled to, and driven by, the forced, incompressible 3D Navier-Stokes equations. The combination, known as the Cahn-Hilliard-Navier-Stokes (CHNS) equations, is used in statistical mechanics to model the motion of a binary fluid. The potential development of singularities (blow-up) in the contours of the order parameter ϕ is an open problem. To address this we have proved a theorem that closely mimics the Beale-Kato-Majda theorem for the 3D incompressible Euler equations [J. T. Beale, T. Kato, and A. J. Majda, Commun. Math. Phys. 94, 61 (1984), 10.1007/BF01212349]. By taking an L∞ norm of the energy of the full binary system, designated as E∞, we have shown that ∫0tE∞(τ ) d τ governs the regularity of solutions of the full 3D system. Our direct numerical simulations (DNSs) of the 3D CHNS equations for (a) a gravity-driven Rayleigh Taylor instability and (b) a constant-energy-injection forcing, with 1283 to 5123 collocation points and over the duration of our DNSs confirm that E∞ remains bounded as far as our computations allow.

  20. Single Photon Emission Computed Tomography-Based Three-Dimensional Conformal Radiotherapy for Hepatocellular Carcinoma With Portal Vein Tumor Thrombus

    SciTech Connect

    Shirai, Shintaro; Sato, Morio Suwa, Kazuhiro; Kishi, Kazushi; Shimono, Chigusa; Kawai, Nobuyuki; Tanihata, Hirohiko; Minamiguchi, Hiroki; Nakai, Motoki

    2009-03-01

    Purpose: To evaluate the safety and efficacy of three-dimensional conformal radiotherapy (3D-CRT) using single photon emission computed tomography (SPECT) in unresectable hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). Methods and Materials: Patients with HCC with PVTT in the first branch and/or main trunk were selected for this study. The optimal beam directions for 3D-CRT were explored using a Tc-99m-galactosyl human serum albumin SPECT image for guidance. The SPECT image was classified as either wedge type or localized type. The clinical target volume to a total dose of 45 or 50 Gy per 18-20 fractions included the main tumor and PVTT in the wedge type and PVTT alone in the localized type. Results: Twenty-six patients were enrolled: 18 with wedge type and 8 with localized type. Mean tumor size was 7.1 cm (range, 4.4-12.3 cm). Clinical target volumes of wedge type vs. localized type were 111.2 cm{sup 3} vs. 48.4 cm{sup 3} (p = 0.010), respectively. Mean dose to normal liver and mean dose to functional liver were 1185 cGy and 988 cGy (p = 0.001) in wedge type and 1046 cGy and 1043 cGy (p = 0.658) in localized type, respectively. Despite an incidence of Child-Pugh B and C of 57.7%, no patients experienced radiation-induced liver disease. The progression of PVTT was inhibited, with an incidence of 92.2%; survival rates at 1 and 2 years were 44% and 30%, respectively. Conclusion: Single photon emission computed tomography-based 3D-CRT enables irradiation of both the main tumor and PVTT with low toxicity and promising survival.

  1. A Query Driven Computer Vision System: A Paradigm for Hierarchical Control Strategies during the Recognition Process of Three Dimensional Visually Perceived Objects.

    DTIC Science & Technology

    1983-04-01

    illuminations, different orientation, focus and zoom of the cameras. 2. For the recovery of three-dimensional information we re interested in how to...three parts: e the computer vision investigation, * the natural language problem , and * the special purpose architecture development. 2. Computer...8217 V’ision The computer vision section will be further subdivided into three sections: * the low level image processing with active sensor * the recovery of

  2. Preliminary assessment of facial soft tissue thickness utilizing three-dimensional computed tomography models of living individuals.

    PubMed

    Parks, Connie L; Richard, Adam H; Monson, Keith L

    2014-04-01

    Facial approximation is the technique of developing a representation of the face from the skull of an unknown individual. Facial approximation relies heavily on average craniofacial soft tissue depths. For more than a century, researchers have employed a broad array of tissue depth collection methodologies, a practice which has resulted in a lack of standardization in craniofacial soft tissue depth research. To combat such methodological inconsistencies, Stephan and Simpson 2008 [15] examined and synthesized a large number of previously published soft tissue depth studies. Their comprehensive meta-analysis produced a pooled dataset of averaged tissue depths and a simplified methodology, which the researchers suggest be utilized as a minimum standard protocol for future craniofacial soft tissue depth research. The authors of the present paper collected craniofacial soft tissue depths using three-dimensional models generated from computed tomography scans of living males and females of four self-identified ancestry groups from the United States ranging in age from 18 to 62 years. This paper assesses the differences between: (i) the pooled mean tissue depth values from the sample utilized in this paper and those published by Stephan 2012 [21] and (ii) the mean tissue depth values of two demographically similar subsets of the sample utilized in this paper and those published by Rhine and Moore 1984 [16]. Statistical test results indicate that the tissue depths collected from the sample evaluated in this paper are significantly and consistently larger than those published by Stephan 2012 [21]. Although a lack of published variance data by Rhine and Moore 1984 [16] precluded a direct statistical assessment, a substantive difference was also concluded. Further, the dataset presented in this study is representative of modern American adults and is, therefore, appropriate for use in constructing contemporary facial approximations.

  3. X-ray computed microtomography of three-dimensional microcracks and self-healing in engineered cementitious composites

    NASA Astrophysics Data System (ADS)

    Fan, Shuai; Li, Mo

    2015-01-01

    Concrete cracking and deterioration can potentially be addressed by innovative self-healing cementitious materials, which can autogenously regain transport properties and mechanical characteristics after the damage self-healing process. For the development of such materials, it is crucial, but challenging, to precisely characterize the extent and quality of self-healing due to a variety of factors. This study adopted x-ray computed microtomography (μCT) to derive three-dimensional morphological data on microcracks before and after healing in engineered cementitious composite (ECC). Scanning electron microscope and energy dispersive x-ray spectroscopy were also used to morphologically and chemically analyze the healing products. This work showed that the evolution of the microcrack 3D structure due to self-healing in cementitious materials can be directly and quantitatively characterized by μCT. A detailed description of the μCT image analysis method applied to ECC self-healing was presented. The results revealed that the self-healing extent and rate strongly depended on initial surface crack width, with smaller crack width favoring fast and robust self-healing. We also found that the self-healing mechanism in cementitious materials is dependent on crack depth. The region of a crack close to the surface (from 0 to around 50-150 μm below the surface) can be sealed quickly with crystalline precipitates. However, at greater depths the healing process inside the crack takes a significantly longer time to occur, with healing products more likely resulting from continued hydration and pozzolanic reactions. Finally, the μCT method was compared with other self-healing characterization methods, with discussions on its importance in generating new scientific knowledge for the development of robust self-healing cementitious materials.

  4. A comparative study of the deviation of the menton on posteroanterior cephalograms and three-dimensional computed tomography

    PubMed Central

    Lee, Hee Jin; Lee, Sungeun; Lee, Eun Joo; Song, In Ja; Kang, Byung-Cheol; Lee, Jae-Seo; Lim, Hoi-Jeong

    2016-01-01

    Purpose Facial asymmetry has been measured by the severity of deviation of the menton (Me) on posteroanterior (PA) cephalograms and three-dimensional (3D) computed tomography (CT). This study aimed to compare PA cephalograms and 3D CT regarding the severity of Me deviation and the direction of the Me. Materials and Methods PA cephalograms and 3D CT images of 35 patients who underwent orthognathic surgery (19 males and 16 females, with an average age of 22.1±3.3 years) were retrospectively reviewed in this study. By measuring the distance and direction of the Me from the midfacial reference line and the midsagittal plane in the cephalograms and 3D CT, respectively, the x-coordinates (x1 and x2) of the Me were obtained in each image. The difference between the x-coordinates was calculated and statistical analysis was performed to compare the severity of Me deviation and the direction of the Me in the two imaging modalities. Results A statistically significant difference in the severity of Me deviation was found between the two imaging modalities (Δx=2.45±2.03 mm, p<0.05) using the one-sample t-test. Statistically significant agreement was observed in the presence of deviation (k=0.64, p<0.05) and in the severity of Me deviation (k=0.27, p<0.05). A difference in the direction of the Me was detected in three patients (8.6%). The severity of the Me deviation was found to vary according to the imaging modality in 16 patients (45.7%). Conclusion The measurement of Me deviation may be different between PA cephalograms and 3D CT in some patients. PMID:27051637

  5. Measuring fetal volume during late first trimester by three-dimensional ultrasonography using virtual organ computer-aided analysis.

    PubMed

    Barra, Daniela A; Lima, Jailson C; Mauad Filho, Francisco; Araujo Júnior, Edward; Martins, Wellington P

    2013-09-01

    Our aim was to determine whether rotating the fetus over its largest axis and reducing the rotational step angle can improve reliability/agreement of fetal volume measurements obtained with three-dimensional ultrasonography (3-DUS). Two observers acquired three 3-DUS data sets for a fetus with a crown-rump length between 45 and 84 mm. These observers determined the fetal volume using virtual organ computer-aided analysis (VOCAL), by three different methods, with a rotational step angle of 30°: (1) minimal manipulation of the 3-DUS data set, fetus rotated over any axis; (2) manipulation of the 3-DUS data set until the fetus could be seen in a standardized manner, fetus rotated over its anteroposterior axis; (3) same 3-DUS data set manipulation, fetus rotated over its longitudinal axis. Intra- and inter-observer reliability/agreement was determined with intra-class correlation coefficients and limits of agreement. In addition, we tested the method that provided the best reliability/agreement results using 15° and 9° of rotational step angles. The time taken to manipulate 3-DUS and determine fetal volume was recorded. The best intra- and inter-observer reliability/agreement results were observed when the fetus was rotated over its longitudinal axis. Reducing rotational step angle to 15° or 9° did not further improve reliability/agreement. The observer took approximately 1 min to determine fetal volume using this method. Our findings indicate that fetal volume should be determined by rotating the fetus over its longitudinal axis, at a rotational step angle of 30°, which is relatively fast and allows analysis of fetal volume with good reliability and agreement.

  6. Imaging of the Coronary Venous System: Validation of Three-Dimensional Rotational Venous Angiography Against Dual-Source Computed Tomography

    SciTech Connect

    Knackstedt, Christian; Muehlenbruch, Georg; Mischke, Karl; Bruners, Philipp; Schimpf, Thomas; Frechen, Dirk; Schummers, Georg; Mahnken, Andreas H.; Guenther, Rolf W.; Kelm, Malte; Schauerte, Patrick

    2008-11-15

    Information on the anatomy of the cardiac venous system (CVS) is increasingly important for cardiac resynchronization therapy or percutaneous transvenous mitral valve annuloplasty. Three-dimensional (3D) imaging can further improve the understanding of the relationship of cardiac structures. This study was performed to validate the accuracy of rotational coronary sinus angiography (CSA) displaying the 3D anatomy of the CVS compared to ECG-gated, contrast-enhanced, cardiac dual-source computed tomography (DSCT). Five domestic pigs (60 kg) underwent DSCT using a standardized examination protocol. Using a standard C-arm for fluoroscopy, a rotational CSA was obtained and 3D-image reconstructions performed. Side branches were identified using both methods and enumerated. Vessel visibility was estimated for each side branch and great cardiac vein/anterior interventricular vein. Also, vessel diameters were measured at distinct landmarks, i.e., side branching. The amount of contrast medium was determined and the effective radiation exposure of both methods was calculated. There was no significant difference regarding the vessel diameter of the great cardiac vein/anterior interventricular vein or its side branches. Also, estimation of vessel visibility was not different between the two imaging modalities. Estimated radiation exposure and amount of contrast medium were lower for rotational CSA. In conclusion, a 3D reconstruction of rotational CSA images is possible. All parts of the CVS are well depicted, allowing a 3D overview of the CVS anatomy. On-site 3D visualization might improve decision making during cardiac interventions. In contrast to DSCT, rotational CSA does not demonstrate the anatomy of the mitral annulus or the course of the left circumflex artery.

  7. 64-Slice spiral computed tomography and three-dimensional reconstruction in the diagnosis of cystic pancreatic tumors

    PubMed Central

    WEN, ZHAOXIA; YAO, FENGQING; WANG, YUXING

    2016-01-01

    The present study aimed to describe the characteristics of cystic pancreatic tumors using computed tomography (CT) and to evaluate the diagnostic accuracy (DA) of post-imaging three-dimensional (3D) reconstruction. Clinical and imaging data, including multi-slice spiral CT scans, enhanced scans and multi-faceted reconstruction, from 30 patients with pathologically confirmed cystic pancreatic tumors diagnosed at the Linyi People's Hospital between August 2008 and June 2014 were retrospectively analyzed. Following the injection of Ultravist® 300 contrast agent, arterial, portal venous and parenchymal phase scans were obtained at 28, 60 and 150 sec, respectively, and 3D reconstructions of the CT images were generated. The average age of the patients was 38.4 years (range, 16–77 years), and the cohort included 5 males and 25 females (ratio, 1:5). The patients included 8 cases of mucinous cystadenoma (DA), 80%]; 9 cases of cystadenocarcinoma (DA, 84%); 6 cases of serous cystadenoma (DA, 100%); 3 cases of solid pseudopapillary tumor (DA, 100%); and 4 cases of intraductal papillary mucinous neoplasm (DA, 100%). 3D reconstructions of CT images were generated and, in the 4 cases of intraductal papillary mucinous neoplasm, the tumor was connected to the main pancreatic duct and multiple mural nodules were detected in one of these cases. The DA of the 3D-reconstructed images of cystic pancreatic tumors was 89.3%. The 64-slice spiral CT and 3D-reconstructed CT images facilitated the visualization of cystic pancreatic tumor characteristics, in particular the connections between the tumor and the main pancreatic duct. In conclusion, the 3D reconstruction of multi-slice CT data may provide an important source of information for the surgical team, in combination with the available clinical data. PMID:27073473

  8. Three-Dimensional Computer Model of the Right Atrium Including the Sinoatrial and Atrioventricular Nodes Predicts Classical Nodal Behaviours

    PubMed Central

    Li, Jue; Inada, Shin; Schneider, Jurgen E.; Zhang, Henggui; Dobrzynski, Halina; Boyett, Mark R.

    2014-01-01

    The aim of the study was to develop a three-dimensional (3D) anatomically-detailed model of the rabbit right atrium containing the sinoatrial and atrioventricular nodes to study the electrophysiology of the nodes. A model was generated based on 3D images of a rabbit heart (atria and part of ventricles), obtained using high-resolution magnetic resonance imaging. Segmentation was carried out semi-manually. A 3D right atrium array model (∼3.16 million elements), including eighteen objects, was constructed. For description of cellular electrophysiology, the Rogers-modified FitzHugh-Nagumo model was further modified to allow control of the major characteristics of the action potential with relatively low computational resource requirements. Model parameters were chosen to simulate the action potentials in the sinoatrial node, atrial muscle, inferior nodal extension and penetrating bundle. The block zone was simulated as passive tissue. The sinoatrial node, crista terminalis, main branch and roof bundle were considered as anisotropic. We have simulated normal and abnormal electrophysiology of the two nodes. In accordance with experimental findings: (i) during sinus rhythm, conduction occurs down the interatrial septum and into the atrioventricular node via the fast pathway (conduction down the crista terminalis and into the atrioventricular node via the slow pathway is slower); (ii) during atrial fibrillation, the sinoatrial node is protected from overdrive by its long refractory period; and (iii) during atrial fibrillation, the atrioventricular node reduces the frequency of action potentials reaching the ventricles. The model is able to simulate ventricular echo beats. In summary, a 3D anatomical model of the right atrium containing the cardiac conduction system is able to simulate a wide range of classical nodal behaviours. PMID:25380074

  9. Evaluation of myocardial infarction size with three-dimensional speckle tracking echocardiography: a comparison with single photon emission computed tomography.

    PubMed

    Wang, Qiushuang; Zhang, Chunhong; Huang, Dangsheng; Zhang, Liwei; Yang, Feifei; An, Xiuzhi; Ouyang, Qiaohong; Zhang, Meiqing; Wang, Shuhua; Guo, Jiarui; Ji, Dongdong

    2015-12-01

    To assess whether global and regional myocardial strains from three-dimensional speckle tracking echocardiography (3D-STE) correlate with myocardial infarction size (MIS) detected by single photon emission computed tomography (SPECT). Fifty-seven patients with a history of ST-segment elevation myocardial infarction (MI) within 3-6 months were enrolled, alongside 24 healthy volunteers. Left ventricular (LV) global area strain, global longitudinal strain (GLS), global radial strain, global circumferential strain, left ventricular ejection fraction (LVEF) and wall motion score index (WMSI) were measured and compared with the corresponding SPECT-detected MISs. Patients were sub-grouped into massive MIS group (MIS ≥ 12%) and small MIS group (MIS < 12%). Myocardial strains of all the LV segments were compared with the corresponding MIS. Global myocardial strain parameters, LVEF and WMSI of the patients were significantly different from the control group (all P < 0.05) and correlated well with MISs, most significantly for GLS (r = 0.728, P < 0.01). Significant differences in myocardial strain parameters were found between the massive and small MIS groups (all P < 0.05). Receiver operating characteristic curve analysis indicated that GLS had a highest diagnostic value and when the cutoff was -13.8%, the area under the curve was 0.84, with the 70.6% sensitivity and 87.5% specificity. Significant differences of myocardial strain parameters were observed between segments with and without transmural MIs (P < 0.01). 3D-STE myocardial strain parameters evaluated LV global MIS, 3D GLS had the highest diagnostic value. It also preliminarily gauged the degree of ischemia and necrosis of regional myocardial segments.

  10. Cochlear Pharmacokinetics with Local Inner Ear Drug Delivery Using a Three-Dimensional Finite-Element Computer Model

    PubMed Central

    Plontke, Stefan K.; Siedow, Norbert; Wegener, Raimund; Zenner, Hans-Peter; Salt, Alec N.

    2006-01-01

    Hypothesis: Cochlear fluid pharmacokinetics can be better represented by three-dimensional (3D) finite-element simulations of drug dispersal. Background: Local drug deliveries to the round window membrane are increasingly being used to treat inner ear disorders. Crucial to the development of safe therapies is knowledge of drug distribution in the inner ear with different delivery methods. Computer simulations allow application protocols and drug delivery systems to be evaluated, and may permit animal studies to be extrapolated to the larger cochlea of the human. Methods: A finite-element 3D model of the cochlea was constructed based on geometric dimensions of the guinea pig cochlea. Drug propagation along and between compartments was described by passive diffusion. To demonstrate the potential value of the model, methylprednisolone distribution in the cochlea was calculated for two clinically relevant application protocols using pharmacokinetic parameters derived from a prior one-dimensional (1D) model. In addition, a simplified geometry was used to compare results from 3D with 1D simulations. Results: For the simplified geometry, calculated concentration profiles with distance were in excellent agreement between the 1D and the 3D models. Different drug delivery strategies produce very different concentration time courses, peak concentrations and basal-apical concentration gradients of drug. In addition, 3D computations demonstrate the existence of substantial gradients across the scalae in the basal turn. Conclusion: The 3D model clearly shows the presence of drug gradients across the basal scalae of guinea pigs, demonstrating the necessity of a 3D approach to predict drug movements across and between scalae with larger cross-sectional areas, such as the human, with accuracy. This is the first model to incorporate the volume of the spiral ligament and to calculate diffusion through this structure. Further development of the 3D model will have to incorporate a more

  11. Experimental and Computational Study of Intraglottal Pressures in a Three-Dimensional Model with a Non-Rectangular Glottal Shape

    NASA Astrophysics Data System (ADS)

    Torkaman, Saeed

    2011-12-01

    The focus of this research was to experimentally and computationally study air pressures and air flows through a model of the human larynx. The model, M6, was a symmetric, three-dimensional physical model. In this model, the transverse plane of the glottis was formed by half-sinusoidal arcs for each medial vocal fold surface, creating a maximum glottal width at the midcoronal section. To study the effects of different glottal shapes, three glottal angles were used, namely, 10° convergent, 0° uniform, and 10° divergent, with the single diameter of 0.16 cm. In addition, to capture the effects of changing glottal diameters, three diameters of 0.16, 0.04, and 0.01 cm in the midcoronal plane were used, all with the single angle of 0°, (i.e., the uniform glottis). Inasmuch as the uniform case with maximum diameter (0.16 cm) was the common case in both groups, a total of five distinct pairs of modeled vocal folds were used. Each case incorporated three rows of 14 pressure taps, located in the inferior-superior direction on the vocal fold surface at locations of the anterior (1/4), middle (1/2), and posterior (3/4) of the anterior-posterior span. This approach (i.e., empirically acquiring air pressure distributions at the three locations) has not been applied in prior studies. For each configuration, transglottal pressures of 0.294, 0.491, 0.981, 1.472, 1.962, and 2.453 kPa (i.e., 3, 5, 10, 15, 20, and 25 cm H2O) were used. To consider the effects of the presence of the arytenoid cartilages on the intraglottal pressures, a simplified model of the cartilages was fabricated as a single structure based on available physiological data, and the intraglottal pressures were measured with and without its presence. With the arytenoid cartilages structure in place, the glottis is an eccentric orifice. The empirical pressures were compared to computational results obtained with the CFD software package FLUENT. Also, flow visualization using a laser sheet and seeded airflow was

  12. Thoracic Temporal Subtraction Three Dimensional Computed Tomography (3D-CT): Screening for Vertebral Metastases of Primary Lung Cancers

    PubMed Central

    Iwano, Shingo; Ito, Rintaro; Umakoshi, Hiroyasu; Karino, Takatoshi; Inoue, Tsutomu; Li, Yuanzhong; Naganawa, Shinji

    2017-01-01

    Purpose We developed an original, computer-aided diagnosis (CAD) software that subtracts the initial thoracic vertebral three-dimensional computed tomography (3D-CT) image from the follow-up 3D-CT image. The aim of this study was to investigate the efficacy of this CAD software during screening for vertebral metastases on follow-up CT images of primary lung cancer patients. Materials and Methods The interpretation experiment included 30 sets of follow-up CT scans in primary lung cancer patients and was performed by two readers (readers A and B), who each had 2.5 years’ experience reading CT images. In 395 vertebrae from C6 to L3, 46 vertebral metastases were identified as follows: osteolytic metastases (n = 17), osteoblastic metastases (n = 14), combined osteolytic and osteoblastic metastases (n = 6), and pathological fractures (n = 9). Thirty-six lesions were in the anterior component (vertebral body), and 10 lesions were in the posterior component (vertebral arch, transverse process, and spinous process). The area under the curve (AUC) by receiver operating characteristic (ROC) curve analysis and the sensitivity and specificity for detecting vertebral metastases were compared with and without CAD for each observer. Results Reader A detected 47 abnormalities on CT images without CAD, and 33 of them were true-positive metastatic lesions. Using CAD, reader A detected 57 abnormalities, and 38 were true positives. The sensitivity increased from 0.717 to 0.826, and on ROC curve analysis, AUC with CAD was significantly higher than that without CAD (0.849 vs. 0.902, p = 0.021). Reader B detected 40 abnormalities on CT images without CAD, and 36 of them were true-positive metastatic lesions. Using CAD, reader B detected 44 abnormalities, and 39 were true positives. The sensitivity increased from 0.783 to 0.848, and AUC with CAD was nonsignificantly higher than that without CAD (0.889 vs. 0.910, p = 0.341). Both readers detected more osteolytic and osteoblastic

  13. Prediction of plasma-induced damage distribution during silicon nitride etching using advanced three-dimensional voxel model

    SciTech Connect

    Kuboi, Nobuyuki Tatsumi, Tetsuya; Kinoshita, Takashi; Shigetoshi, Takushi; Fukasawa, Masanaga; Komachi, Jun; Ansai, Hisahiro

    2015-11-15

    The authors modeled SiN film etching with hydrofluorocarbon (CH{sub x}F{sub y}/Ar/O{sub 2}) plasma considering physical (ion bombardment) and chemical reactions in detail, including the reactivity of radicals (C, F, O, N, and H), the area ratio of Si dangling bonds, the outflux of N and H, the dependence of the H/N ratio on the polymer layer, and generation of by-products (HCN, C{sub 2}N{sub 2}, NH, HF, OH, and CH, in addition to CO, CF{sub 2}, SiF{sub 2}, and SiF{sub 4}) as ion assistance process parameters for the first time. The model was consistent with the measured C-F polymer layer thickness, etch rate, and selectivity dependence on process variation for SiN, SiO{sub 2}, and Si film etching. To analyze the three-dimensional (3D) damage distribution affected by the etched profile, the authors developed an advanced 3D voxel model that can predict the time-evolution of the etched profile and damage distribution. The model includes some new concepts for gas transportation in the pattern using a fluid model and the property of voxels called “smart voxels,” which contain details of the history of the etching situation. Using this 3D model, the authors demonstrated metal–oxide–semiconductor field-effect transistor SiN side-wall etching that consisted of the main-etch step with CF{sub 4}/Ar/O{sub 2} plasma and an over-etch step with CH{sub 3}F/Ar/O{sub 2} plasma under the assumption of a realistic process and pattern size. A large amount of Si damage induced by irradiated hydrogen occurred in the source/drain region, a Si recess depth of 5 nm was generated, and the dislocated Si was distributed in a 10 nm deeper region than the Si recess, which was consistent with experimental data for a capacitively coupled plasma. An especially large amount of Si damage was also found at the bottom edge region of the metal–oxide–semiconductor field-effect transistors. Furthermore, our simulation results for bulk fin-type field-effect transistor side-wall etching

  14. Three-dimensional micro-level computational study of Wolff's law via trabecular bone remodeling in the human proximal femur using design space topology optimization.

    PubMed

    Boyle, Christopher; Kim, Il Yong

    2011-03-15

    The law of bone remodeling, commonly referred to as Wolff's Law, asserts that the internal trabecular bone adapts to external loadings, reorienting with the principal stress trajectories to maximize mechanical efficiency creating a naturally optimum structure. The goal of the current study was to utilize an advanced structural optimization algorithm, called design space optimization (DSO), to perform a micro-level three-dimensional finite element bone remodeling simulation on the human proximal femur and analyse the results to determine the validity of Wolff's hypothesis. DSO optimizes the layout of material by iteratively distributing it into the areas of highest loading, while simultaneously changing the design domain to increase computational efficiency. The result is a "fully stressed" structure with minimized compliance and increased stiffness. The large-scale computational simulation utilized a 175 μm mesh resolution and the routine daily loading activities of walking and stair climbing. The resulting anisotropic trabecular architecture was compared to both Wolff's trajectory hypothesis and natural femur samples from literature using a variety of visualization techniques, including radiography and computed tomography (CT). The results qualitatively revealed several anisotropic trabecular regions, that were comparable to the natural human femurs. Quantitatively, the various regional bone volume fractions from the computational results were consistent with quantitative CT analyses. The global strain energy proceeded to become more uniform during optimization; implying increased mechanical efficiency was achieved. The realistic simulated trabecular geometry suggests that the DSO method can accurately predict bone adaptation due to mechanical loading and that the proximal femur is an optimum structure as the Wolff hypothesized.

  15. A comparative study between data obtained from conventional lateral cephalometry and reconstructed three-dimensional computed tomography images

    PubMed Central

    Oh, Suseok; Kim, Ci-Young

    2014-01-01

    Objectives The aim of this study was to verify the concordance of the measurement values when the same cephalometric analysis method was used for two-dimensional (2D) cephalometric radiography and three-dimensional computed tomography (3D CT), and to identify which 3D Frankfort horizontal (FH) plane was the most concordant with FH plane used for cephalometric radiography. Materials and Methods Reference horizontal plane was FH plane. Palatal angle and occlusal plane angle was evaluated with FH plane. Gonial angle (GA), palatal angle, upper occlusal plane angle (UOPA), mandibular plane angle (MPA), U1 to occlusal plane angle, U1 to FH plane angle, SNA and SNB were obtained on 2D cephalmetries and reconstructed 3D CT. The values measured eight angles in 2D lateral cephalometry and reconstructed 3D CT were evaluated by intraclass correlation coefficiency (ICC). It also was evaluated to identify 3D FH plane with high degree of concordance to 2D one by studying which one in four FH planes shows the highest degree of concordance with 2D FH plane. Results ICCs of MPA (0.752), UOPA (0.745), SNA (0.798) and SNB (0.869) were high. On the other hand, ICCs of gonial angle (0.583), palatal angle (0.287), U1 to occlusal plane (0.404), U1 to FH plane (0.617) were low respectively. Additionally GA and MPA acquired from 2D were bigger than those on 3D in all 20 patients included in this study. Concordance between one UOPA from 2D and four UOPAs from 3D CT were evaluated by ICC values. Results showed no significant difference among four FH planes defined on 3D CT. Conclusion FH plane that can be set on 3D CT does not have difference in concordance from FH plane on lateral cephalometry. However, it is desirable to define FH plane on 3D CT with two orbitales and one porion considering the reproduction of orbitale itself. PMID:25045639

  16. Three-Dimensional, Multi-scale, and Multi-variance Dispersivity Upscaling for Hierarchical Sedimentary Deposit using Parallel Computing

    NASA Astrophysics Data System (ADS)

    Zhang, M.; Zhang, Y.; Lichtner, P. C.

    2013-12-01

    /tailing behavior of the FHM can generally be captured by the HSMs. At all the variances tested, the 8-unit upscaled model is always the most accurate. When the variance is low to moderate, this model can provide accurate to adequate predictions of all the FHM plume moments. In addition, upscaled dispersivities computed with the stochastic versus deterministic techniques yield similar solute predictions, which suggest that in this analysis, an ergodic transport regime has emerged. However, when the variance of ln(k) increases to 4.5, the upscaled dispersivities predicted by the stochastic methods result in significant upstream dispersion that is nonphysical. In this case, the HSMs cannot capture the FHM plume moments for the given ln(K) variance. In summary, simulation results suggest that the upscaling dispersivity can be used to accurately capture solute transport in low ln(K) variance systems but fails to describe the solute motion if system variance is high. Reference: Mingkan Zhang, and Ye Zhang, Multiscale, Multi-variance Dispersivity Upscaling for A Three-Dimensional Hierarchical Aquifer: Developing and Testing a Parallel Random Walk Method with a Drift Term in the Dispersion Tensor, Water Resources Research, in preparation.

  17. Classification of some active compounds and their inactive analogues using two three-dimensional molecular descriptors derived from computation of three-dimensional convex hulls for structures theoretically generated for them.

    PubMed

    Lin, T H; Yu, Y S; Chen, H J

    2000-01-01

    Two three-dimensional (3D) molecular descriptors are used to classify 73 protease inhibitors against the human immunodeficiency virus type 1 (HIV-1). X-ray structures of these HIV-1 protease bound inhibitors are used as templates to generate the most probable bioactive conformations of the inhibitors. A convex hull computation algorithm is applied to each structure generated. The frequency of atoms lying on the vertexes of each hull is counted. Vertexes of the same atomic charge state are then gathered together as a set of commonly exposed groups for all the structures generated. The first 3D descriptor is computed as the maximum molecular path length among any three distinct commonly exposed groups, while the second 3D one is computed as the maximum molecular path length among any three atoms of nonconvex hull vertexes. We find that the 73 HIV-1 protease inhibitors can be classified by the first 3D descriptor into two groups, which agrees with the result of visual classification using the activity data as a criterion for these compounds. The classification scheme is then used to classify a database of 427 active trypsin inhibitors and their inactive analogues. The structures of these compounds are generated theoretically from steps of energy minimization and molecular dynamics. Classification for all these compounds is performed using the SYBYL hierarchical clustering method on the first 3D descriptor and then the second 3D one computed. It is found that some inactive analogues are completely separated from the active inhibitors at the first stage of classification using the first 3D descriptor. Most of the highly active inhibitors are classified into a cluster at the second stage of classification using the second 3D descriptor. Finally, most of these highly active inhibitors are separated from all the accompanying inactive analogues in the cluster through a structural alignment process using a set of commonly exposed groups determined for them.

  18. Computer simulation of vapor-liquid phase separation in two- and three-dimensional fluids. II. Domain structure

    NASA Astrophysics Data System (ADS)

    Yamamoto, Ryoichi; Nakanishi, Koichiro

    1995-02-01

    Fluids undergoing phase separation exhibit complicated domain patterns. In this study we perform molecular-dynamics simulations for two- and three-dimensional Lennard-Jones fluids in order to investigate the relationship between statistical properties of domain structure and system temperature. The asymptotic form factor of each pattern is obtained using scaling and its temperature dependence studied. In particular the asymptotic tail of the form factor is analyzed. This tail is related to the domain-wall structure. At low system, temperatures, the form factor satisfies Porod's law; its asymptotic tail decreases as S(k)~k-(D+1) where D is the system dimensionality. However, it is found that the decay of the asymptotic tail becomes slower than that of the Porod tail at higher temperatures in both the two- and three-dimensional systems. This indicates that the dimension of the domain wall is fractal and increases with increasing system temperature.

  19. Accuracy of three-dimensional soft tissue predictions in orthognathic surgery after Le Fort I advancement osteotomies.

    PubMed

    Ullah, R; Turner, P J; Khambay, B S

    2015-02-01

    Prediction of postoperative facial appearance after orthognathic surgery can be used for communication, managing patients' expectations,avoiding postoperative dissatisfaction and exploring different treatment options. We have assessed the accuracy of 3dMD Vultus in predicting the final 3-dimensional soft tissue facial morphology after Le Fort I advancement osteotomy. We retrospectively studied 13 patients who were treated with a Le Fort I advancement osteotomy alone. We used routine cone-beam computed tomographic (CT) images taken immediately before and a minimum of 6 months after operation, and 3dMD Vultus to virtually reposition the preoperative maxilla and mandible in their post operative positions to generate a prediction of what the soft tissue would look like. Segmented anatomical areas of the predicted mesh were then compared with the actual soft tissue. The means of the absolute distance between the 90th percentile of the mesh points for each region were calculated, and a one-sample Student's t test was used to calculate if the difference differed significantly from 3 mm.The differences in the mean absolute distances between the actual soft tissue and the prediction were significantly below 3 mm for all segmented anatomical areas (p < 0.001), and ranged from 0.65 mm (chin) to 1.17 mm (upper lip). 3dMD Vultus produces clinically satisfactory 3-dimensional facial soft tissue predictions after Le Fort I advancement osteotomy. The mass-spring model for prediction seems to be able to predict the position of the lip and chin, but its ability to predict nasal and paranasal areas could be improved.

  20. Evaluation of three-dimensional position change of the condylar head after orthognathic surgery using computer-aided design/computer-aided manufacturing-made condyle positioning jig.

    PubMed

    Kim, Hyung-Mo; Baek, Seung-Hak; Kim, Tae-Yun; Choi, Jin-Young

    2014-11-01

    This study was performed to evaluate the efficacy of computer-aided design/computer-aided manufacturing (CAM/CAD)-made condyle positioning jig in orthognathic surgery. The sample consisted of 40 mandibular condyles of 20 patients with class III malocclusion who underwent bilateral sagittal split ramus osteotomy with semirigid fixation (6 men and 14 women; mean age, 25 y; mean amount of mandibular setback, 5.8 mm). Exclusion criteria were patients who needed surgical correction of the frontal ramal inclination and had signs and symptoms of the temporomandibular disorder before surgery. Three-dimensional computed tomograms were taken 1 month before the surgery (T1) and 1 day after the surgery (T2). The condylar position was evaluated at the T1 and T2 stages on the axial, frontal, and sagittal aspects in the three-dimensional coordinates. The linear change of the posterior border of the proximal segment of the ramus between T1 and T2 was also evaluated in 30 condyles (15 patients), with the exception of 10 condyles of 5 patients who received mandibular angle reduction surgery. There was no significant difference in the condylar position in the frontal and sagittal aspects (P > 0.05). Although there was a significant difference in the condylar position in the axial aspect (P < 0.01), the amount of difference was less than 1 mm and 1 degree; it can be considered clinically nonsignificant. In the linear change of the posterior border of the proximal segment of the ramus, the mean change was 1.4 mm and 60% of the samples showed a minimal change of less than 1 mm. The results of this study suggest that CAD/CAM-made condyle positioning jig is easy to install and reliable to use in orthognathic surgery.

  1. Thin film deposition at atmospheric pressure using dielectric barrier discharges: Advances on three-dimensional porous substrates and functional coatings

    NASA Astrophysics Data System (ADS)

    Fanelli, Fiorenza; Bosso, Piera; Mastrangelo, Anna Maria; Fracassi, Francesco

    2016-07-01

    Surface processing of materials by atmospheric pressure dielectric barrier discharges (DBDs) has experienced significant growth in recent years. Considerable research efforts have been directed for instance to develop a large variety of processes which exploit different DBD electrode geometries for the direct and remote deposition of thin films from precursors in gas, vapor and aerosol form. This article briefly reviews our recent progress in thin film deposition by DBDs with particular focus on process optimization. The following examples are provided: (i) the plasma-enhanced chemical vapor deposition of thin films on an open-cell foam accomplished by igniting the DBD throughout the entire three-dimensional (3D) porous structure of the substrate, (ii) the preparation of hybrid organic/inorganic nanocomposite coatings using an aerosol-assisted process, (iii) the DBD jet deposition of coatings containing carboxylic acid groups and the improvement of their chemical and morphological stability upon immersion in water.

  2. Volume rendering based on magnetic resonance imaging: advances in understanding the three-dimensional anatomy of the human knee

    PubMed Central

    Anastasi, Giuseppe; Bramanti, Placido; Di Bella, Paolo; Favaloro, Angelo; Trimarchi, Fabio; Magaudda, Ludovico; Gaeta, Michele; Scribano, Emanuele; Bruschetta, Daniele; Milardi, Demetrio

    2007-01-01

    The choice of medical imaging techniques, for the purpose of the present work aimed at studying the anatomy of the knee, derives from the increasing use of images in diagnostics, research and teaching, and the subsequent importance that these methods are gaining within the scientific community. Medical systems using virtual reality techniques also offer a good alternative to traditional methods, and are considered among the most important tools in the areas of research and teaching. In our work we have shown some possible uses of three-dimensional imaging for the study of the morphology of the normal human knee, and its clinical applications. We used the direct volume rendering technique, and created a data set of images and animations to allow us to visualize the single structures of the human knee in three dimensions. Direct volume rendering makes use of specific algorithms to transform conventional two-dimensional magnetic resonance imaging sets of slices into see-through volume data set images. It is a technique which does not require the construction of intermediate geometric representations, and has the advantage of allowing the visualization of a single image of the full data set, using semi-transparent mapping. Digital images of human structures, and in particular of the knee, offer important information about anatomical structures and their relationships, and are of great value in the planning of surgical procedures. On this basis we studied seven volunteers with an average age of 25 years, who underwent magnetic resonance imaging. After elaboration of the data through post-processing, we analysed the structure of the knee in detail. The aim of our investigation was the three-dimensional image, in order to comprehend better the interactions between anatomical structures. We believe that these results, applied to living subjects, widen the frontiers in the areas of teaching, diagnostics, therapy and scientific research. PMID:17645453

  3. Computer Simulation of Spatial Arrangement and Connectivity of Particles in Three-Dimensional Microstructure: Application to Model Electrical Conductivity of Polymer Matrix Composite

    NASA Technical Reports Server (NTRS)

    Louis, P.; Gokhale, A. M.

    1996-01-01

    Computer simulation is a powerful tool for analyzing the geometry of three-dimensional microstructure. A computer simulation model is developed to represent the three-dimensional microstructure of a two-phase particulate composite where particles may be in contact with one another but do not overlap significantly. The model is used to quantify the "connectedness" of the particulate phase of a polymer matrix composite containing hollow carbon particles in a dielectric polymer resin matrix. The simulations are utilized to estimate the morphological percolation volume fraction for electrical conduction, and the effective volume fraction of the particles that actually take part in the electrical conduction. The calculated values of the effective volume fraction are used as an input for a self-consistent physical model for electrical conductivity. The predicted values of electrical conductivity are in very good agreement with the corresponding experimental data on a series of specimens having different particulate volume fraction.

  4. Accuracy Assessment of Three-dimensional Surface Reconstructions of In vivo Teeth from Cone-beam Computed Tomography

    PubMed Central

    Sang, Yan-Hui; Hu, Hong-Cheng; Lu, Song-He; Wu, Yu-Wei; Li, Wei-Ran; Tang, Zhi-Hui

    2016-01-01

    Background: The accuracy of three-dimensional (3D) reconstructions from cone-beam computed tomography (CBCT) has been particularly important in dentistry, which will affect the effectiveness of diagnosis, treatment plan, and outcome in clinical practice. The aims of this study were to assess the linear, volumetric, and geometric accuracy of 3D reconstructions from CBCT and to investigate the influence of voxel size and CBCT system on the reconstructions results. Methods: Fifty teeth from 18 orthodontic patients were assigned to three groups as NewTom VG 0.15 mm group (NewTom VG; voxel size: 0.15 mm; n = 17), NewTom VG 0.30 mm group (NewTom VG; voxel size: 0.30 mm; n = 16), and VATECH DCTPRO 0.30 mm group (VATECH DCTPRO; voxel size: 0.30 mm; n = 17). The 3D reconstruction models of the teeth were segmented from CBCT data manually using Mimics 18.0 (Materialise Dental, Leuven, Belgium), and the extracted teeth were scanned by 3Shape optical scanner (3Shape A/S, Denmark). Linear and volumetric deviations were separately assessed by comparing the length and volume of the 3D reconstruction model with physical measurement by paired t-test. Geometric deviations were assessed by the root mean square value of the imposed 3D reconstruction and optical models by one-sample t-test. To assess the influence of voxel size and CBCT system on 3D reconstruction, analysis of variance (ANOVA) was used (α = 0.05). Results: The linear, volumetric, and geometric deviations were −0.03 ± 0.48 mm, −5.4 ± 2.8%, and 0.117 ± 0.018 mm for NewTom VG 0.15 mm group; −0.45 ± 0.42 mm, −4.5 ± 3.4%, and 0.116 ± 0.014 mm for NewTom VG 0.30 mm group; and −0.93 ± 0.40 mm, −4.8 ± 5.1%, and 0.194 ± 0.117 mm for VATECH DCTPRO 0.30 mm group, respectively. There were statistically significant differences between groups in terms of linear measurement (P < 0.001), but no significant difference in terms of volumetric measurement (P = 0.774). No statistically significant difference were

  5. Three dimensional strained semiconductors

    DOEpatents

    Voss, Lars; Conway, Adam; Nikolic, Rebecca J.; Leao, Cedric Rocha; Shao, Qinghui

    2016-11-08

    In one embodiment, an apparatus includes a three dimensional structure comprising a semiconductor material, and at least one thin film in contact with at least one exterior surface of the three dimensional structure for inducing a strain in the structure, the thin film being characterized as providing at least one of: an induced strain of at least 0.05%, and an induced strain in at least 5% of a volume of the three dimensional structure. In another embodiment, a method includes forming a three dimensional structure comprising a semiconductor material, and depositing at least one thin film on at least one surface of the three dimensional structure for inducing a strain in the structure, the thin film being characterized as providing at least one of: an induced strain of at least 0.05%, and an induced strain in at least 5% of a volume of the structure.

  6. Volumetric changes in pharyngeal airway in Class II division 1 patients treated with Forsus-fixed functional appliance: A three-dimensional cone-beam computed tomography study

    PubMed Central

    Temani, Parul; Jain, Pradeep; Rathee, Pooja; Temani, Ruchira

    2016-01-01

    Objective: Recent years have witnessed a renewed interest to determine a quantifiable relationship between mandibular advancement performed with an orthodontic appliance and the resulting airway volume. The study was conducted to evaluate the volumetric changes in pharyngeal airway space using cone-beam computed tomography (CBCT) in Class II division 1 patients with retrognathic mandible treated by Forsus-fixed functional appliance and to compare them with their pretreatment findings. Materials and Methods: Thirty patients with Class II division 1 malocclusion of age group 10–17 years were selected randomly and evaluated for changes in pharyngeal airway volume with and without Forsus-fixed functional appliance. Patients in each group underwent CBCT scan of head and neck region at pretreatment stage and 6 months after the initial scan. Institutional approval for the project was obtained from the Ethical Committee. Volumetric changes of upper (oropharynx) and lower (hypopharynx) pharyngeal airways were measured on scanogram using computer software and intragroup comparisons were done. Results: There was a statistically significant increase in the volume of both hypopharynx and oropharynx and also total airway volume in patients treated with Forsus-fixed functional appliance. Three-dimensional reconstruction of the airway also demonstrates a considerable increase in pharyngeal airway space. Conclusion: Forsus-fixed functional appliance can be a promising appliance for improving pharyngeal airway volume in Class II division 1 patients with retrognathic mandible thus preventing obstructive sleep apnea and other respiratory problems in future. However, the long-term implications of this treatment modality need further consideration and a longer period of follow-up. PMID:27041897

  7. Fast calculation method for computer-generated cylindrical holograms based on the three-dimensional Fourier spectrum.

    PubMed

    Sando, Yusuke; Barada, Daisuke; Jackin, Boaz Jessie; Yatagai, Toyohiko

    2013-12-01

    The relation between a three-dimensional (3D) object and its diffracted wavefront in the 3D Fourier space is discussed at first and then a rigorous diffraction formula onto cylindrical surfaces is derived. The azimuthal direction and the spatial frequency direction corresponding to height can be expressed with a one-dimensional (1D) convolution integral and a 1D inverse Fourier transform in the 3D Fourier space, respectively, and fast Fourier transforms are available for fast calculation. A numerical simulation of a diffracted wavefront on cylindrical surfaces is presented. An alternative optical experiment equivalent of the optical reconstruction from cylindrical holograms is also demonstrated.

  8. Three-dimensional stellarator codes

    PubMed Central

    Garabedian, P. R.

    2002-01-01

    Three-dimensional computer codes have been used to develop quasisymmetric stellarators with modular coils that are promising candidates for a magnetic fusion reactor. The mathematics of plasma confinement raises serious questions about the numerical calculations. Convergence studies have been performed to assess the best configurations. Comparisons with recent data from large stellarator experiments serve to validate the theory. PMID:12140367

  9. Creating Three-Dimensional Scenes

    ERIC Educational Resources Information Center

    Krumpe, Norm

    2005-01-01

    Persistence of Vision Raytracer (POV-Ray), a free computer program for creating photo-realistic, three-dimensional scenes and a link for Mathematica users interested in generating POV-Ray files from within Mathematica, is discussed. POV-Ray has great potential in secondary mathematics classrooms and helps in strengthening students' visualization…

  10. Three-dimensional marginal separation

    NASA Technical Reports Server (NTRS)

    Duck, Peter W.

    1988-01-01

    The three dimensional marginal separation of a boundary layer along a line of symmetry is considered. The key equation governing the displacement function is derived, and found to be a nonlinear integral equation in two space variables. This is solved iteratively using a pseudo-spectral approach, based partly in double Fourier space, and partly in physical space. Qualitatively, the results are similar to previously reported two dimensional results (which are also computed to test the accuracy of the numerical scheme); however quantitatively the three dimensional results are much different.

  11. Computed tomographic-dacryocystography (CT-DCG) of the normal canine nasolacrimal drainage system with three-dimensional reconstruction.

    PubMed

    Rached, Paula A; Canola, Júlio C; Schlüter, Claudia; Laus, José L; Oechtering, Gerhard; de Almeida, Denise E; Ludewig, Eberhard

    2011-05-01

    The aims of the study were (1) to quantify the influence of selected imaging parameters on the image quality (slice thickness, mAs, and beam orientation) defining optimal conditions for scan protocols and (2) to evaluate the benefits of the 3D reconstruction techniques for visualization of NDS structures in dogs. CT-DCG was performed bilaterally in 32 heads of dogs. CT transverse images were obtained using a combination of two slice thickness values (0.8 mm and 2 mm) and two mAs values (50 mAs and 300 mAs). Two beam projection orientations were also tested: transverse plane (perpendicular to the hard palate) and oblique to the hard palate. Three-dimensional images were obtained using Volume Rendering (VR). Transverse beam projection proved to be superior for the assessment of the inferior and superior lacrimal canaliculi and lacrimal sac. In this study, there was no statistical difference regarding mAs values (50 mAs and 300 mAs) and slice thickness values (0.8 mm and 2 mm). Three-dimensional images were helpful for the assessment of topographic relationship between nasolacrimal structures and cranial landmarks.

  12. Computer Simulation Study of Human Locomotion with a Three-Dimensional Entire-Body Neuro-Musculo-Skeletal Model

    NASA Astrophysics Data System (ADS)

    Hase, Kazunori; Yamazaki, Nobutoshi

    A model having a three-dimensional entire-body structure and consisting of both the neuronal system and the musculo-skeletal system was proposed to precisely simulate human walking motion. The dynamics of the human body was represented by a 14-rigid-link system and 60 muscular models. The neuronal system was represented by three sub-systems: the rhythm generator system consisting of 32 neural oscillators, the sensory feedback system, and the peripheral system expressed by static optimization. Unknown neuronal parameters were adjusted by a numerical search method using the evaluative criterion for locomotion that was defined by a hybrid between the locomotive energy efficiency and the smoothness of the muscular tensions. The model could successfully generate continuous and three-dimensional walking patterns and stabilized walking against mechanical perturbation. The walking pattern was more stable than that of the model based on dynamic optimization, and more precise than that of the previous model based on a similar neuronal system.

  13. Complex three dimensional modelling of porous media using high performance computing and multi-scale incompressible approach

    NASA Astrophysics Data System (ADS)

    Martin, R.; Orgogozo, L.; Noiriel, C. N.; Guibert, R.; Golfier, F.; Debenest, G.; Quintard, M.

    2013-05-01

    In the context of biofilm growth in porous media, we developed high performance computing tools to study the impact of biofilms on the fluid transport through pores of a solid matrix. Indeed, biofilms are consortia of micro-organisms that are developing in polymeric extracellular substances that are generally located at a fluid-solid interfaces like pore interfaces in a water-saturated porous medium. Several applications of biofilms in porous media are encountered for instance in bio-remediation methods by allowing the dissolution of organic pollutants. Many theoretical studies have been done on the resulting effective properties of these modified media ([1],[2], [3]) but the bio-colonized porous media under consideration are mainly described following simplified theoretical media (stratified media, cubic networks of spheres ...). Therefore, recent experimental advances have provided tomography images of bio-colonized porous media which allow us to observe realistic biofilm micro-structures inside the porous media [4]. To solve closure system of equations related to upscaling procedures in realistic porous media, we solve the velocity field of fluids through pores on complex geometries that are described with a huge number of cells (up to billions). Calculations are made on a realistic 3D sample geometry obtained by X micro-tomography. Cell volumes are coming from a percolation experiment performed to estimate the impact of precipitation processes on the properties of a fluid transport phenomena in porous media [5]. Average permeabilities of the sample are obtained from velocities by using MPI-based high performance computing on up to 1000 processors. Steady state Stokes equations are solved using finite volume approach. Relaxation pre-conditioning is introduced to accelerate the code further. Good weak or strong scaling are reached with results obtained in hours instead of weeks. Factors of accelerations of 20 up to 40 can be reached. Tens of geometries can now be

  14. Three-dimensional Nitrogen-Doped Graphene Supported Molybdenum Disulfide Nanoparticles as an Advanced Catalyst for Hydrogen Evolution Reaction.

    PubMed

    Dong, Haifeng; Liu, Conghui; Ye, Haitao; Hu, Linping; Fugetsu, Bunshi; Dai, Wenhao; Cao, Yu; Qi, Xueqiang; Lu, Huiting; Zhang, Xueji

    2015-12-07

    An efficient three-dimensional (3D) hybrid material of nitrogen-doped graphene sheets (N-RGO) supporting molybdenum disulfide (MoS(2)) nanoparticles with high-performance electrocatalytic activity for hydrogen evolution reaction (HER) is fabricated by using a facile hydrothermal route. Comprehensive microscopic and spectroscopic characterizations confirm the resulting hybrid material possesses a 3D crumpled few-layered graphene network structure decorated with MoS(2) nanoparticles. Electrochemical characterization analysis reveals that the resulting hybrid material exhibits efficient electrocatalytic activity toward HER under acidic conditions with a low onset potential of 112 mV and a small Tafel slope of 44 mV per decade. The enhanced mechanism of electrocatalytic activity has been investigated in detail by controlling the elemental composition, electrical conductance and surface morphology of the 3D hybrid as well as Density Functional Theory (DFT) calculations. This demonstrates that the abundance of exposed active sulfur edge sites in the MoS(2) and nitrogen active functional moieties in N-RGO are synergistically responsible for the catalytic activity, whilst the distinguished and coherent interface in MoS(2)/N-RGO facilitates the electron transfer during electrocatalysis. Our study gives insights into the physical/chemical mechanism of enhanced HER performance in MoS(2)/N-RGO hybrids and illustrates how to design and construct a 3D hybrid to maximize the catalytic efficiency.

  15. Three-dimensional imaging technologies: a priority for the advancement of tissue engineering and a challenge for the imaging community.

    PubMed

    Teodori, Laura; Crupi, Annunziata; Costa, Alessandra; Diaspro, Alberto; Melzer, Susanne; Tarnok, Attila

    2017-01-01

    Tissue engineering/regenerative medicine (TERM) is an interdisciplinary field that applies the principle of engineering and life sciences to restore/replace damaged tissues/organs with in vitro artificially-created ones. Research on TERM quickly moves forward. Today newest technologies and discoveries, such as 3D-/bio-printing, allow in vitro fabrication of ex-novo made tissues/organs, opening the door to wide and probably never-ending application possibilities, from organ transplant to drug discovery, high content screening and replacement of laboratory animals. Imaging techniques are fundamental tools for the characterization of tissue engineering (TE) products at any stage, from biomaterial/scaffold to construct/organ analysis. Indeed, tissue engineers need versatile imaging methods capable of monitoring not only morphological but also functional and molecular features, allowing three-dimensional (3D) and time-lapse in vivo analysis, in a non-destructive, quantitative, multidimensional analysis of TE constructs, to analyze their pre-implantation quality assessment and their fate after implantation. This review focuses on the newest developments in imaging technologies and applications in the context of requirements of the different steps of the TERM field, describing strengths and weaknesses of the current imaging approaches.

  16. Three-dimensional Nitrogen-Doped Graphene Supported Molybdenum Disulfide Nanoparticles as an Advanced Catalyst for Hydrogen Evolution Reaction

    PubMed Central

    Dong, Haifeng; Liu, Conghui; Ye, Haitao; Hu, Linping; Fugetsu, Bunshi; Dai, Wenhao; Cao, Yu; Qi, Xueqiang; Lu, Huiting; Zhang, Xueji

    2015-01-01

    An efficient three-dimensional (3D) hybrid material of nitrogen-doped graphene sheets (N-RGO) supporting molybdenum disulfide (MoS2) nanoparticles with high-performance electrocatalytic activity for hydrogen evolution reaction (HER) is fabricated by using a facile hydrothermal route. Comprehensive microscopic and spectroscopic characterizations confirm the resulting hybrid material possesses a 3D crumpled few-layered graphene network structure decorated with MoS2 nanoparticles. Electrochemical characterization analysis reveals that the resulting hybrid material exhibits efficient electrocatalytic activity toward HER under acidic conditions with a low onset potential of 112 mV and a small Tafel slope of 44 mV per decade. The enhanced mechanism of electrocatalytic activity has been investigated in detail by controlling the elemental composition, electrical conductance and surface morphology of the 3D hybrid as well as Density Functional Theory (DFT) calculations. This demonstrates that the abundance of exposed active sulfur edge sites in the MoS2 and nitrogen active functional moieties in N-RGO are synergistically responsible for the catalytic activity, whilst the distinguished and coherent interface in MoS2/N-RGO facilitates the electron transfer during electrocatalysis. Our study gives insights into the physical/chemical mechanism of enhanced HER performance in MoS2/N-RGO hybrids and illustrates how to design and construct a 3D hybrid to maximize the catalytic efficiency. PMID:26639026

  17. The CMC:3DPNS computer program for prediction of three-dimensional, subsonic, turbulent aerodynamic juncture region flow. Volume 1: Theoretical

    NASA Technical Reports Server (NTRS)

    Baker, A. J.

    1982-01-01

    An order-of-magnitude analysis of the subsonic three dimensional steady time averaged Navier-Stokes equations, for semibounded aerodynamic juncture geometries, yields the parabolic Navier-Stokes simplification. The numerical solution of the resultant pressure Poisson equation is cast into complementary and particular parts, yielding an iterative interaction algorithm with an exterior three dimensional potential flow solution. A parabolic transverse momentum equation set is constructed, wherein robust enforcement of first order continuity effects is accomplished using a penalty differential constraint concept within a finite element solution algorithm. A Reynolds stress constitutive equation, with low turbulence Reynolds number wall functions, is employed for closure, using parabolic forms of the two-equation turbulent kinetic energy-dissipation equation system. Numerical results document accuracy, convergence, and utility of the developed finite element algorithm, and the CMC:3DPNS computer code applied to an idealized wing-body juncture region. Additional results document accuracy aspects of the algorithm turbulence closure model.

  18. Tissue optical clearing, three-dimensional imaging, and computer morphometry in whole mouse lungs and human airways.

    PubMed

    Scott, Gregory D; Blum, Emily D; Fryer, Allison D; Jacoby, David B

    2014-07-01

    In whole adult mouse lung, full identification of airway nerves (or other cellular/subcellular objects) has not been possible due to patchy distribution and micron-scale size. Here we describe a method using tissue clearing to acquire the first complete image of three-dimensional (3D) innervation in the lung. We then created a method to pair analysis of nerve (or any other colabeled epitope) images with identification of 3D tissue compartments and airway morphometry by using fluorescent casting and morphometry software (which we designed and are making available as open-source). We then tested our method to quantify a sparse heterogeneous nerve population by examining visceral pleural nerves. Finally, we demonstrate the utility of our method in human tissue to image full thickness innervation in irregular 3D tissue compartments and to quantify sparse objects (intrinsic airway ganglia). Overall, this method can uniquely pair the advantages of whole tissue imaging and cellular/subcellular fluorescence microscopy.

  19. Pointwise assessment of three-dimensional computer reconstruction of mitral leaflet surfaces from rotationally scanned echocardiograms in vitro.

    PubMed

    Bashein, Gerard; Legget, Malcolm E; Detmer, Paul R

    2004-03-01

    Three-dimensional transesophageal echocardiography offers promise for improved understanding of mitral leaflet pathology, but it has not been validated quantitatively, nor has the minimum number of imaging planes for satisfactory reconstruction been determined with a rotational scanning geometry. This study assessed its accuracy in vitro by comparing, on a 1 x 1-mm grid, the surfaces of mitral leaflets derived from 5-degree rotational ultrasonic scans with those derived from laser scans of casts of the atrial side of the leaflets. Overall, the ultrasonically derived surface had a mean absolute deviation of 0.65 +/- 0.12 mm from the laser-derived surface. Using only alternate imaging planes (10-degree increments) made no significant difference in the overall distribution of deviations (P =.56), although the distributions on some individual specimens differed markedly. We conclude that 5-degree rotational scanning in vitro can reconstruct the mitral valve leaflets with sufficient accuracy and detail to render clinically important features.

  20. Three-Dimensional Incompressible Navier-Stokes Flow Computations about Complete Configurations Using a Multiblock Unstructured Grid Approach

    NASA Technical Reports Server (NTRS)

    Sheng, Chunhua; Hyams, Daniel G.; Sreenivas, Kidambi; Gaither, J. Adam; Marcum, David L.; Whitfield, David L.

    2000-01-01

    A multiblock unstructured grid approach is presented for solving three-dimensional incompressible inviscid and viscous turbulent flows about complete configurations. The artificial compressibility form of the governing equations is solved by a node-based, finite volume implicit scheme which uses a backward Euler time discretization. Point Gauss-Seidel relaxations are used to solve the linear system of equations at each time step. This work employs a multiblock strategy to the solution procedure, which greatly improves the efficiency of the algorithm by significantly reducing the memory requirements by a factor of 5 over the single-grid algorithm while maintaining a similar convergence behavior. The numerical accuracy of solutions is assessed by comparing with the experimental data for a submarine with stem appendages and a high-lift configuration.

  1. Three Dimensional Illustrating--Three-Dimensional Vision and Deception of Sensibility

    ERIC Educational Resources Information Center

    Szállassy, Noémi; Gánóczy, Anita; Kriska, György

    2009-01-01

    The wide-spread digital photography and computer use gave the opportunity for everyone to make three-dimensional pictures and to make them public. The new opportunities with three-dimensional techniques give chance for the birth of new artistic photographs. We present in detail the biological roots of three-dimensional visualization, the phenomena…

  2. Advanced treatment of biologically pretreated coal gasification wastewater by a novel integration of three-dimensional catalytic electro-Fenton and membrane bioreactor.

    PubMed

    Jia, Shengyong; Han, Hongjun; Hou, Baolin; Zhuang, Haifeng

    2015-12-01

    Laboratorial scale experiments were conducted to investigate a novel system three-dimensional catalytic electro-Fenton (3DCEF, catalyst of sewage sludge based activated carbon which loaded Fe3O4) integrating with membrane bioreactor (3DCEF-MBR) on advanced treatment of biologically pretreated coal gasification wastewater. The results indicated that 3DCEF-MBR represented high efficiencies in eliminating COD and total organic carbon, giving the maximum removal efficiencies of 80% and 75%, respectively. The integrated 3DCEF-MBR system significantly reduced the transmembrane pressure, giving 35% lower than conventional MBR after 30 days operation. The enhanced hydroxyl radical oxidation and bacteria self repair function were the mechanisms for 3DCEF-MBR performance. Therefore, the integrated 3DCEF-MBR was expected to be the promising technology for advanced treatment in engineering applications.

  3. Advanced computations in plasma physics

    NASA Astrophysics Data System (ADS)

    Tang, W. M.

    2002-05-01

    Scientific simulation in tandem with theory and experiment is an essential tool for understanding complex plasma behavior. In this paper we review recent progress and future directions for advanced simulations in magnetically confined plasmas with illustrative examples chosen from magnetic confinement research areas such as microturbulence, magnetohydrodynamics, magnetic reconnection, and others. Significant recent progress has been made in both particle and fluid simulations of fine-scale turbulence and large-scale dynamics, giving increasingly good agreement between experimental observations and computational modeling. This was made possible by innovative advances in analytic and computational methods for developing reduced descriptions of physics phenomena spanning widely disparate temporal and spatial scales together with access to powerful new computational resources. In particular, the fusion energy science community has made excellent progress in developing advanced codes for which computer run-time and problem size scale well with the number of processors on massively parallel machines (MPP's). A good example is the effective usage of the full power of multi-teraflop (multi-trillion floating point computations per second) MPP's to produce three-dimensional, general geometry, nonlinear particle simulations which have accelerated progress in understanding the nature of turbulence self-regulation by zonal flows. It should be emphasized that these calculations, which typically utilized billions of particles for thousands of time-steps, would not have been possible without access to powerful present generation MPP computers and the associated diagnostic and visualization capabilities. In general, results from advanced simulations provide great encouragement for being able to include increasingly realistic dynamics to enable deeper physics insights into plasmas in both natural and laboratory environments. The associated scientific excitement should serve to

  4. The vector of jaw muscle force as determined by computer-generated three dimensional simulation: a test of Greaves' model.

    PubMed

    Clausen, Philip; Wroe, Stephen; McHenry, Colin; Moreno, Karen; Bourke, Jason

    2008-11-14

    We present results from a detailed three-dimensional finite element analysis of the cranium and mandible of the Australian dingo (Canis lupus dingo) during a range of feeding activities and compare results with predictions based on two-dimensional methodology [Greaves, W.S., 2000. Location of the vector of jaw muscle force in mammals. Journal of Morphology 243, 293-299]. Greaves showed that the resultant muscle vector intersects the mandible line slightly posterior to the lower third molar (m3). Our work demonstrates that this is qualitatively correct, although the actual point is closer to the jaw joint. We show that it is theoretically possible for the biting side of the mandible to dislocate during unilateral biting; however, the bite point needs to be posterior to m3. Simulations show that reduced muscle activation on the non-biting side can considerably diminish the likelihood of dislocation with only a minor decrease in bite force during unilateral biting. By modulating muscle recruitment the animal may be able to maximise bite force whilst minimising the risk of dislocation.

  5. Application of an object-oriented programming paradigm in three-dimensional computer modeling of mechanically active gastrointestinal tissues.

    PubMed

    Rashev, P Z; Mintchev, M P; Bowes, K L

    2000-09-01

    The aim of this study was to develop a novel three-dimensional (3-D) object-oriented modeling approach incorporating knowledge of the anatomy, electrophysiology, and mechanics of externally stimulated excitable gastrointestinal (GI) tissues and emphasizing the "stimulus-response" principle of extracting the modeling parameters. The modeling method used clusters of class hierarchies representing GI tissues from three perspectives: 1) anatomical; 2) electrophysiological; and 3) mechanical. We elaborated on the first four phases of the object-oriented system development life-cycle: 1) analysis; 2) design; 3) implementation; and 4) testing. Generalized cylinders were used for the implementation of 3-D tissue objects modeling the cecum, the descending colon, and the colonic circular smooth muscle tissue. The model was tested using external neural electrical tissue excitation of the descending colon with virtual implanted electrodes and the stimulating current density distributions over the modeled surfaces were calculated. Finally, the tissue deformations invoked by electrical stimulation were estimated and represented by a mesh-surface visualization technique.

  6. Measuring of Abdominal Aortic Aneurysm with Three-Dimensional Computed Tomography Reconstruction before Endovascular Aortic Aneurysm Repair

    PubMed Central

    Chung, Yoona; Joh, Jin Hyun; Park, Ho-Chul

    2017-01-01

    Purpose Conventional computed tomography (CT) is the gold standard method for case planning for endovascular aortic aneurysm repair (EVAR). However, aortography with a marking catheter is needed for measuring the actual length of an aneurysm. With advances in imaging technology, a 3-dimensional (3D) workstation can obviate the need for the aortography. The objective of this study was to determine whether a 3D workstation could obviate the need for aortography for EVAR. Materials and Methods One vascular surgeon and 1 interventional radiologist retrospectively assessed axial CT scans and reformatted the 3D CT scans by using the iNtuition workstation (TeraRecon Inc., San Mateo, CA, USA) for 25 patients who underwent EVAR. Four measurements of diameter and length were obtained from each modality. The actual length of an aneurysm for the proper graft was decided by 2 observers by reviewing the aortography with a marking catheter. Results The measurements from the 2 modalities were reproducible with intraobserver correlation coefficients of 0.89 to 1.0 for conventional CT and 0.98 to 1.0 for 3D workstation. Interobserver correlation coefficients were 0.29 to 0.95 for conventional CT and 0.85 to 0.99 for the 3D workstation. The length of the aneurysm for proper main graft coincided in 18 and 14 patients according to the conventional CT scan and in 21 and 18 patients according to the 3D workstation, respectively. Conclusion The interobserver agreement in planning EVAR was significantly better with the iNtuition 3D workstation. But aortography with a marking catheter may still be needed for selecting the proper graft. PMID:28377909

  7. Computed analysis of three-dimensional cone-beam computed tomography angiography for determination of tumor-feeding vessels during chemoembolization of liver tumor: a pilot study.

    PubMed

    Deschamps, Frederic; Solomon, Stephen B; Thornton, Raymond H; Rao, Pramod; Hakime, Antoine; Kuoch, Viseth; de Baere, Thierry

    2010-12-01

    The purpose of this study was to evaluate computed analysis of three-dimensional (3D) cone-beam computed tomography angiography (CTA) of the liver for determination of subsegmental tumor-feeding vessels (FVs). Eighteen consecutive patients underwent transarterial chemoembolization (TACE) from January to October 2008 for 25 liver tumors (15 hepatocellular carcinomas [HCCs] and 10 neuroendocrine metastases). Anteroposterior projection angiogram (two-dimensional [2D]) and 3D cone-beam CTA images were acquired by injection of the common hepatic artery. Retrospectively, FVs were independently identified by three radiology technologists using a software package (S) that automatically determines FVs by analysis of 3D images. Subsequently, three interventional radiologists (IRs) independently identified FVs by reviewing the 2D images followed by examination of the 3D images. Finally, the "ground truth" for the number and location of FVs was obtained by consensus among the IRs, who were allowed to use any imaging-including 2D, 3D, and all oblique or selective angiograms-for such determination. Sensitivities, durations, and degrees of agreement for review of 2D, 3D, and S results were evaluated. Sensitivity of 3D (73%) was higher than 2D (64%) images for identification of FVs (P = 0.036). The sensitivity of S (93%) was higher than 2D (P = 0.02) and 3D (P = 0.005) imaging. The duration for review of 3D imaging was longer than that for 2D imaging (187 vs. 94 s, P = 0.0001) or for S (135 s, P = 0.0001). The degree of agreement between the IRs using 2D and 3D imaging were 54% and 62%, respectively, whereas it was 82% between the three radiology technologists using S. These preliminary data show that computed determination of FVs is both accurate and sensitive.

  8. A computational method for three-dimensional reconstruction of the microarchitecture of myometrial smooth muscle from histological sections

    PubMed Central

    Lutton, E. Josiah; Lammers, Wim J. E. P.; James, Sean

    2017-01-01

    Background The fibrous structure of the myometrium has previously been characterised at high resolutions in small tissue samples (< 100 mm3) and at low resolutions (∼500 μm per voxel edge) in whole-organ reconstructions. However, no high-resolution visualisation of the myometrium at the organ level has previously been attained. Methods and results We have developed a technique to reconstruct the whole myometrium from serial histological slides, at a resolution of approximately 50 μm per voxel edge. Reconstructions of samples taken from human and rat uteri are presented here, along with histological verification of the reconstructions and detailed investigation of the fibrous structure of these uteri, using a range of tools specifically developed for this analysis. These reconstruction techniques enable the high-resolution rendering of global structure previously observed at lower resolution. Moreover, structures observed previously in small portions of the myometrium can be observed in the context of the whole organ. The reconstructions are in direct correspondence with the original histological slides, which allows the inspection of the anatomical context of any features identified in the three-dimensional reconstructions. Conclusions and significance The methods presented here have been used to generate a faithful representation of myometrial smooth muscle at a resolution of ∼50 μm per voxel edge. Characterisation of the smooth muscle structure of the myometrium by means of this technique revealed a detailed view of previously identified global structures in addition to a global view of the microarchitecture. A suite of visualisation tools allows researchers to interrogate the histological microarchitecture. These methods will be applicable to other smooth muscle tissues to analyse fibrous microarchitecture. PMID:28301486

  9. The use of a wax bite wafer and a double computed tomography scan procedure to obtain a three-dimensional augmented virtual skull model.

    PubMed

    Swennen, Gwen R J; Mommaerts, Maurice Y; Abeloos, Johan; De Clercq, Calix; Lamoral, Philippe; Neyt, Nathalie; Casselman, Jan; Schutyser, Filip

    2007-05-01

    A detailed visualization of the interocclusal relationship is essential in a three-dimensional virtual planning setup for orthognathic and facial orthomorphic surgery. The purpose of this study was to introduce and evaluate the use of a wax bite wafer in combination with a double computed tomography (CT) scan procedure to augment the three-dimensional virtual model of the skull with a detailed dental surface. A total of 10 orthognathic patients were scanned after a standardized multislice CT scanning protocol with dose reduction with their wax bite wafer in place. Afterward, the impressions of the upper and lower arches and the wax bite wafer were scanned for each patient separately using a high-resolution standardized multislice CT scanning protocol. Accurate fitting of the virtual impressions on the wax bite wafer was done with surface matching using iterative closest points. Consecutively, automatic rigid point-based registration of the wax bite wafer on the patient scan was performed to implement the digital virtual dental arches into the patient's skull model (Maxilim, version 2.0; Medicim NV, St-Niklaas, Belgium). Probability error histograms showed errors of < or =0.16 mm (25% percentile), < or =0.31 mm (50% percentile), and < or =0.92 (90% percentile) for iterative closest point surface matching. The mean registration error for automatic point-based registration was 0.17 +/- 0.07 mm (range, 0.12-0.22 mm). The combination of the wax bite wafer with the double CT scan procedure allowed for the setup of an accurate three-dimensional virtual augmented model of the skull with detailed dental surface. However, from a clinical workload, data handling, and computational point of view, this method is too time-consuming to be introduced in the clinical routine.

  10. TEMPEST: A three-dimensional time-dependent computer program for hydrothermal analysis: Volume 2, Assessment and verification results

    SciTech Connect

    Eyler, L L; Trent, D S; Budden, M J

    1983-09-01

    During the course of the TEMPEST computer code development a concurrent effort was conducted to assess the code's performance and the validity of computed results. The results of this work are presented in this document. The principal objective of this effort was to assure the code's computational correctness for a wide range of hydrothermal phenomena typical of fast breeder reactor application. 47 refs., 94 figs., 6 tabs.

  11. Correction of severe wrist deformity following physeal arrest of the distal radius with the aid of a three-dimensional computer simulation.

    PubMed

    Murase, Tsuyoshi; Oka, Kunihiro; Moritomo, Hisao; Goto, Akira; Sugamoto, Kazuomi; Yoshikawa, Hideki

    2009-11-01

    Growth arrest following physeal injury may result in severe limb deformity. We report a case of complex wrist deformity caused by injury to the distal radial physis resulting in radial shortening and abnormal inclination of the radial articular surface, which was successfully treated by gradual correction after computer simulation. The simulation enabled us to develop an appropriate operative plan by accurately calculating the axis of the three-dimensional (3D) deformity using computer bone models. In the simulative surgery with a full-size stereolithography bone model, an Ilizarov external fixator was applied to the radius such that its two hinges were located on the virtual axis of the deformity, which was reproduced in the actual surgery. This technique of 3D computer simulation is a useful alternative to plan accurate correction of complex limb deformities following growth arrest.

  12. RNA FRABASE 2.0: an advanced web-accessible database with the capacity to search the three-dimensional fragments within RNA structures

    PubMed Central

    2010-01-01

    Background Recent discoveries concerning novel functions of RNA, such as RNA interference, have contributed towards the growing importance of the field. In this respect, a deeper knowledge of complex three-dimensional RNA structures is essential to understand their new biological functions. A number of bioinformatic tools have been proposed to explore two major structural databases (PDB, NDB) in order to analyze various aspects of RNA tertiary structures. One of these tools is RNA FRABASE 1.0, the first web-accessible database with an engine for automatic search of 3D fragments within PDB-derived RNA structures. This search is based upon the user-defined RNA secondary structure pattern. In this paper, we present and discuss RNA FRABASE 2.0. This second version of the system represents a major extension of this tool in terms of providing new data and a wide spectrum of novel functionalities. An intuitionally operated web server platform enables very fast user-tailored search of three-dimensional RNA fragments, their multi-parameter conformational analysis and visualization. Description RNA FRABASE 2.0 has stored information on 1565 PDB-deposited RNA structures, including all NMR models. The RNA FRABASE 2.0 search engine algorithms operate on the database of the RNA sequences and the new library of RNA secondary structures, coded in the dot-bracket format extended to hold multi-stranded structures and to cover residues whose coordinates are missing in the PDB files. The library of RNA secondary structures (and their graphics) is made available. A high level of efficiency of the 3D search has been achieved by introducing novel tools to formulate advanced searching patterns and to screen highly populated tertiary structure elements. RNA FRABASE 2.0 also stores data and conformational parameters in order to provide "on the spot" structural filters to explore the three-dimensional RNA structures. An instant visualization of the 3D RNA structures is provided. RNA FRABASE

  13. COMMIX-PPC: A three-dimensional transient multicomponent computer program for analyzing performance of power plant condensers. Volume 2, User`s guide and manual

    SciTech Connect

    Chien, T.H.; Domanus, H.M.; Sha, W.T.

    1993-02-01

    The COMMIX-PPC computer program is an extended and improved version of earlier COMMIX codes and is specifically designed for evaluating the thermal performance of power plant condensers. The COMMIX codes are general-purpose computer programs for the analysis of fluid flow and heat transfer in complex industrial systems. In COMMIX-PPC, two major features have been added to previously published COMMIX codes. One feature is the incorporation of one-dimensional conservation of mass. momentum, and energy equations on the tube side, and the proper accounting for the thermal interaction between shell and tube side through the porous medium approach. The other added feature is the extension of the three-dimensional conservation equations for shell-side flow to treat the flow of a multicomponent medium. COMMIX-PPC is designed to perform steady-state and transient three-dimensional analysis of fluid flow with heat transfer in a power plant condenser. However, the code is designed in a generalized fashion so that, with some modification. it can be used to analyze processes in any heat exchanger or other single-phase engineering applications.

  14. COMMIX-PPC: A three-dimensional transient multicomponent computer program for analyzing performance of power plant condensers. Volume 1, Equations and numerics

    SciTech Connect

    Chien, T.H.; Domanus, H.M.; Sha, W.T.

    1993-02-01

    The COMMIX-PPC computer pregrain is an extended and improved version of earlier COMMIX codes and is specifically designed for evaluating the thermal performance of power plant condensers. The COMMIX codes are general-purpose computer programs for the analysis of fluid flow and heat transfer in complex Industrial systems. In COMMIX-PPC, two major features have been added to previously published COMMIX codes. One feature is the incorporation of one-dimensional equations of conservation of mass, momentum, and energy on the tube stile and the proper accounting for the thermal interaction between shell and tube side through the porous-medium approach. The other added feature is the extension of the three-dimensional conservation equations for shell-side flow to treat the flow of a multicomponent medium. COMMIX-PPC is designed to perform steady-state and transient. Three-dimensional analysis of fluid flow with heat transfer tn a power plant condenser. However, the code is designed in a generalized fashion so that, with some modification, it can be used to analyze processes in any heat exchanger or other single-phase engineering applications. Volume I (Equations and Numerics) of this report describes in detail the basic equations, formulation, solution procedures, and models for a phenomena. Volume II (User`s Guide and Manual) contains the input instruction, flow charts, sample problems, and descriptions of available options and boundary conditions.

  15. Fast generation of three-dimensional computational boundary-conforming periodic grids of C-type. [for turbine blades and propellers

    NASA Technical Reports Server (NTRS)

    Dulikravich, D. S.

    1982-01-01

    A fast computer program, GRID3C, was developed to generate multilevel three dimensional, C type, periodic, boundary conforming grids for the calculation of realistic turbomachinery and propeller flow fields. The technique is based on two analytic functions that conformally map a cascade of semi-infinite slits to a cascade of doubly infinite strips on different Riemann sheets. Up to four consecutively refined three dimensional grids are automatically generated and permanently stored on four different computer tapes. Grid nonorthogonality is introduced by a separate coordinate shearing and stretching performed in each of three coordinate directions. The grids are easily clustered closer to the blade surface, the trailing and leading edges and the hub or shroud regions by changing appropriate input parameters. Hub and duct (or outer free boundary) have different axisymmetric shapes. A vortex sheet of arbitrary thickness emanating smoothly from the blade trailing edge is generated automatically by GRID3C. Blade cross sectional shape, chord length, twist angle, sweep angle, and dihedral angle can vary in an arbitrary smooth fashion in the spanwise direction.

  16. Three-dimensional perspective visualization

    NASA Technical Reports Server (NTRS)

    Hussey, Kevin

    1991-01-01

    It was demonstrated that image processing computer graphic techniques can provide an effective means of physiographic analysis of remotely sensed regions through the use of three-dimensional perspective rendering. THe methods used to simulate and animate three-dimensional surfaces from two-dimensional imagery and digital elevation models are explained. A brief historic look at JPL's efforts in this field and several examples of animations, illustrating the evolution of these techniques from 1985, are shown. JPL's current research in this area is discussed along with examples of technology transfer and potential commercial application. The software is part of the VICAR (Video Image Communication and Retrieval) image processing system which was developed at the Multimission Image Processing Laboratory of JPL.

  17. A Computational Icing Effects Study for a Three-Dimensional Wing: Comparison with Experimental Data and Investigation of Spanwise Variation

    NASA Technical Reports Server (NTRS)

    Thompson, D.; Mogili, P.; Chalasani, S.; Addy, H.; Choo, Y.

    2004-01-01

    Steady-state solutions of the Reynolds-averaged Navier-Stokes (RANS) equations were computed using the Colbalt flow solver for a constant-section, rectangular wing based on an extruded two-dimensional glaze ice shape. The one equation Spalart-Allmaras turbulence model was used. The results were compared with data obtained from a recent wind tunnel test. Computed results indicate that the steady RANS solutions do not accurately capture the recirculating region downstream of the ice accretion, even after a mesh refinement. The resulting predicted reattachment is farther downstream than indicated by the experimental data. Additionally, the solutions computed on a relatively coarse baseline mesh had detailed flow characteristics that were different from those computed on the refined mesh or the experimental data. Steady RANS solutions were also computed to investigate the effects of spanwise variation in the ice shape. The spanwise variation was obtained via a bleeding function that merged the ice shape with the clean wing using a sinusoidal spanwise variation. For these configurations, the results predicted for the extruded shape provided conservative estimates for the performance degradation of the wing. Additionally, the spanwise variation in the ice shape and the resulting differences in the flow fields did not significantly change the location of the primary reattachment.

  18. Near- and far-field scattering from arbitrary three-dimensional aggregates of coated spheres using parallel computing.

    PubMed

    Boyde, Lars; Chalut, Kevin J; Guck, Jochen

    2011-02-01

    Many scientific fields--including astronomy, climatology, and biology, among others--require the calculation of the scattered optical fields from multiparticle distributions. In the present study, we combine the established results for the scattering from clusters of homogeneous spheres and from single core-shell particles into a computationally tractable solution that is valid for irregular configurations of nonidentical, coated particles. The presented multiparticle scattering (MPS) model is based on a generalized Lorenz-Mie theory framework and the vector translation theorems for the vector spherical harmonics. We provide the MPS model in both the near and far fields, and for plane-wave and Gaussian beam illumination. A message-passing-interface protocol is used for the computational implementation of the model in a parallel computer program. The computer model is validated by verifying the accuracy of the vector translation theorems utilized in our theoretical methods and by qualitative comparison to existing multiparticle scattering data. We conclude by presenting the scattering profiles from several examples of particle distributions. This MPS model is a practicable method of calculating the optical fields arising in the scattering from particle aggregates and is straightforwardly extensible to arbitrary illumination and to more complex internal-particle structures, such as stratified spheres. Vital applications of this model include the exact computation of forces exerted on irregular objects in optical traps and the simulation of light propagation through biological tissues.

  19. Near- and far-field scattering from arbitrary three-dimensional aggregates of coated spheres using parallel computing

    NASA Astrophysics Data System (ADS)

    Boyde, Lars; Chalut, Kevin J.; Guck, Jochen

    2011-02-01

    Many scientific fields—including astronomy, climatology, and biology, among others—require the calculation of the scattered optical fields from multiparticle distributions. In the present study, we combine the established results for the scattering from clusters of homogeneous spheres and from single core-shell particles into a computationally tractable solution that is valid for irregular configurations of nonidentical, coated particles. The presented multiparticle scattering (MPS) model is based on a generalized Lorenz-Mie theory framework and the vector translation theorems for the vector spherical harmonics. We provide the MPS model in both the near and far fields, and for plane-wave and Gaussian beam illumination. A message-passing-interface protocol is used for the computational implementation of the model in a parallel computer program. The computer model is validated by verifying the accuracy of the vector translation theorems utilized in our theoretical methods and by qualitative comparison to existing multiparticle scattering data. We conclude by presenting the scattering profiles from several examples of particle distributions. This MPS model is a practicable method of calculating the optical fields arising in the scattering from particle aggregates and is straightforwardly extensible to arbitrary illumination and to more complex internal-particle structures, such as stratified spheres. Vital applications of this model include the exact computation of forces exerted on irregular objects in optical traps and the simulation of light propagation through biological tissues.

  20. An unusual case of thoracic ectopia cordis in a Toggenburg Goat and its three-dimensional images constructed with X-ray computed tomography.

    PubMed

    Lai, Jyh-Mirn; Wu, Jui-Te; Yang, Wei-Cheng; Chao, Ming-Hsin; Nagahata, Hajime

    2016-05-01

    A two-day-old female Toggenburg goat with thoracic ectopia cordis (EC) was diagnosed via radiography and computed tomography. The goat was born with EC, defects of the sternum and a supra-umbilical abdominal wall, but without the presence of Cantrell's syndrome. Necropsy and histopathological findings indicated the affected kid had malformation of the heart with an enlarged left ventricle. The findings showed the heart (9 x 5 x 5 cm) stayed outside the thorax, and was covered by a semitransparent membrane. This report is the first to describe a case of thoracic EC in a goat whose sternum was not developed fully and was not connected to the ribs. It is also the first paper to describe three-dimensional images of this condition constructed from computed tomography scans.

  1. Three-dimensional component alignment and functional outcome in computer-navigated total knee arthroplasty: a prospective, randomized study comparing two navigation systems.

    PubMed

    Harvie, Paul; Sloan, Karen; Beaver, Richard J

    2011-12-01

    Computer navigation in total knee arthroplasty produces better component alignment than conventional techniques. Different navigation systems exist. We undertook a prospective, randomized study comparing 2 navigations systems (Stryker Full Navigation and Stryker Articular Surface Mounted [ASM] navigation systems). Three-dimensional component alignment (Perth computed tomographic knee protocol) and function at 1 year (Knee Society Scores) were assessed. Forty patients participated (20 fully navigated and 20 ASM-navigated total knee arthroplasties). Cohorts were well matched according to sex, age, and body mass index. No statistically significant difference was seen in any parameter of 3-dimensional component alignment or function between cohorts. Operative time for the ASM cohort was significantly less than the fully navigated cohort (P = .001). Both systems performed equally well, and therefore, surgeon preference should determine which system is used.

  2. Comparison of different fixation methods following sagittal split ramus osteotomies using three-dimensional finite elements analysis. Part 1: advancement surgery-posterior loading.

    PubMed

    Erkmen, E; Simşek, B; Yücel, E; Kurt, A

    2005-07-01

    The purpose of this study was to evaluate the mechanical behavior of different fixation methods used in bilateral sagittal split ramus osteotomy (BSSRO). Part 1 comprises of the results of the analysis for mandibular advancement, four different fixation configurations of six hole fragmentation mini plates with monocortical screws and lag screws and posterior loading conditions in the molar and premolar region. The finite element analysis method (FEA) appears suitable for simulating complex mechanical stress situations in the maxillofacial region. The mechanical behavior of selected lag screws with linear or triangular configuration and double parallel or single oblique six hole mini plates with monocortical screws were compared by FEA after 5 mm BSSRO advancement procedure. Four separate three-dimensional finite element models of the mandible were created to simulate the BSSRO and corresponding fixation methods. These models consisted of 122,717 elements and 25,048 nodes. The mechanical parameters of the materials studied were adopted from the literature or were based on manufacturer's information. 500 N posterior occlusal loads were simulated on the distal segments. The commercial finite element solver MSC Marc software was utilized to calculate the stress fields on both the segments and fixative appliances. It was concluded that the use of 2.0mm lag screws placed in a triangular configuration following the BSSRO advancement surgery provides sufficient stability with any rotational movement and less stress fields at the osteotomy site, when compared with the other rigid fixation methods used in the current study.

  3. High-order adaptive method for computing two-dimensional invariant manifolds of three-dimensional maps

    NASA Astrophysics Data System (ADS)

    Wróbel, Jacek K.; Goodman, Roy H.

    2013-07-01

    An efficient and accurate numerical method is presented for computing invariant manifolds of maps which arise in the study of dynamical systems. A quasi-interpolation method due to Hering-Bertram et al. is used to decrease the number of points needed to compute a portion of the manifold. Bézier triangular patches are used in this construction, together with adaptivity conditions based on properties of these patches. Several numerical tests are performed, which show the method to compare favorably with previous approaches.

  4. Turbulent structures in wall-bounded shear flows observed via three-dimensional numerical simulators. [using the Illiac 4 computer

    NASA Technical Reports Server (NTRS)

    Leonard, A.

    1980-01-01

    Three recent simulations of tubulent shear flow bounded by a wall using the Illiac computer are reported. These are: (1) vibrating-ribbon experiments; (2) study of the evolution of a spot-like disturbance in a laminar boundary layer; and (3) investigation of turbulent channel flow. A number of persistent flow structures were observed, including streamwise and vertical vorticity distributions near the wall, low-speed and high-speed streaks, and local regions of intense vertical velocity. The role of these structures in, for example, the growth or maintenance of turbulence is discussed. The problem of representing the large range of turbulent scales in a computer simulation is also discussed.

  5. Three-dimensional conformal radiotherapy for locally advanced (Stage II and worse) head-and-neck cancer: Dosimetric and clinical evaluation

    SciTech Connect

    Portaluri, Maurizio . E-mail: portaluri@hotmail.com; Fucilli, Fulvio I.M.; Castagna, Roberta; Bambace, Santa; Pili, Giorgio; Tramacere, Francesco; Russo, Donatella; Francavilla, Maria Carmen

    2006-11-15

    Purpose: To evaluate the dosimetric parameters of three-dimensional conformal radiotherapy (3D-CRT) in locally advanced head-and-neck tumors (Stage II and above) and the effects on xerostomia. Methods and Materials: A total of 49 patients with histologically proven squamous cell cancer of the head and neck were consecutively treated with 3D-CRT using a one-point setup technique; 17 had larynx cancer, 12 oropharynx, 12 oral cavity, and 6 nasopharynx cancer; 2 had other sites of cancer. Of the 49 patients, 41 received postoperative RT and 8 definitive treatment. Also, 13 were treated with cisplatin-based chemotherapy before and during RT; in 6 cases, 5-fluorouracil was added. The follow-up time was 484-567 days (median, 530 days). Results: One-point setup can deliver 96% of the prescribed dose to the isocenter, to the whole planning target volume, including all node levels of the neck and without overdosages. The mean dose to the primary planning target volume was 49.54 {+-} 4.82 Gy (51.53 {+-} 5.47 Gy for larynx cases). The average dose to the contralateral parotid gland was approximately 38 Gy (30 Gy for larynx cases). The maximal dose to the spinal cord was 46 Gy. A Grade 0 Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer xerostomia score corresponded to a mean dose of 30 Gy to one parotid gland. A lower xerostomia score with a lower mean parotid dose and longer follow-up seemed to give rise to a sort of functional recovery phenomenon. Conclusion: Three dimensional-CRT in head-and-neck cancers permits good coverage of the planning target volume with about 10-11 segments and one isocenter. With a mean dose of approximately 30 Gy to the contralateral parotid, we observed no or mild xerostomia.

  6. Utilization of high resolution computed tomography to visualize the three dimensional structure and function of plant vasculature

    Technology Transfer Automated Retrieval System (TEKTRAN)

    High resolution x-ray computed tomography (HRCT) is a non-destructive diagnostic imaging technique with sub-micron resolution capability that is now being used to evaluate the structure and function of plant xylem network in three dimensions (3D). HRCT imaging is based on the same principles as medi...

  7. Introductory Molecular Orbital Theory: An Honors General Chemistry Computational Lab as Implemented Using Three-Dimensional Modeling Software

    ERIC Educational Resources Information Center

    Ruddick, Kristie R.; Parrill, Abby L.; Petersen, Richard L.

    2012-01-01

    In this study, a computational molecular orbital theory experiment was implemented in a first-semester honors general chemistry course. Students used the GAMESS (General Atomic and Molecular Electronic Structure System) quantum mechanical software (as implemented in ChemBio3D) to optimize the geometry for various small molecules. Extended Huckel…

  8. Validation of standardized computer analyses for licensing evaluation/TRITON two-dimensional and three-dimensional models for light water reactor fuel

    SciTech Connect

    Bowman, S. M.; Gill, D. F.

    2006-07-01

    The isotopic depletion capabilities of the new Standardized Computer Analyses for Licensing Evaluation control module TRITON, coupled with ORIGEN-S, were evaluated using spent fuel assays from several commercial light water reactors with both standard and mixed-oxide fuel assemblies. Calculations were performed using the functional modules NEWT and KENO-VI. NEWT is a two-dimensional, arbitrary-geometry, discrete-ordinates transport code, and KENO-VI is a three-dimensional Monte Carlo transport code capable of handling complex three-dimensional geometries. To validate the codes and data used in depletion calculations, numerical predictions were compared with experimental measurements for a total of 29 samples taken from the Calvert Cliffs, Obrigheim, and San Onofre pressurized water reactors and the Gundremmingen boiling water reactor. Similar comparisons have previously been performed at the Oak Ridge National Laboratory for the one-dimensional SAS2H control module. The SAS2H, TRITON/KENO-VI, and TRITON/NEWT results were compared for corresponding samples. All analyses showed that TRITON/KENO-VI and TRITON/NEWT produced typically similar or better results than SAS2H. The calculations performed in this validation study demonstrate that the depletion capabilities of TRITON accurately model spent fuel depletion and decay. (authors)

  9. Effect of therapeutic insoles on the medial longitudinal arch in patients with flatfoot deformity: a three-dimensional loading computed tomography study

    PubMed Central

    Kido, Masamitsu; Ikoma, Kazuya; Hara, Yusuke; Imai, Kan; Maki, Masahiro; Ikeda, Takumi; Fujiwara, Hiroyoshi; Tokunaga, Daisaku; Inoue, Nozomu; Kubo, Toshikazu

    2014-01-01

    Background Insoles are frequently used in orthotic therapy as the standard conservative treatment for symptomatic flatfoot deformity to rebuild the arch and stabilize the foot. However, the effectiveness of therapeutic insoles remains unclear. In this study, we assessed the effectiveness of therapeutic insoles for flatfoot deformity using subject-based three-dimensional (3D) computed tomography (CT) models by evaluating the load responses of the bones in the medial longitudinal arch in vivo in 3D. Methods We studied eight individuals (16 feet) with mild flatfoot deformity. CT scans were performed on both feet under non-loaded and full-body-loaded conditions, first with accessory insoles and then with therapeutic insoles under the same conditions. Three-dimensional CT models were constructed for the tibia and the tarsal and metatarsal bones of the medial longitudinal arch (i.e., first metatarsal bone, cuneiforms, navicular, talus, and calcaneus). The rotational angles between the tarsal bones were calculated under loading with accessory insoles or therapeutic insoles and compared. Findings Compared with the accessory insoles, the therapeutic insoles significantly suppressed the eversion of the talocalcaneal joint. Interpretation This is the first study to precisely verify the usefulness of therapeutic insoles (arch support and inner wedges) in vivo. PMID:25457972

  10. A computer program to calculate the resistivity and induced polarization response for a three-dimensional body in the presence of buried electrodes

    USGS Publications Warehouse

    Daniels, Jeffrey J.

    1977-01-01

    Three-dimensional induced polarization and resistivity modeling for buried electrode configurations can be achieved by adapting surface integral techniques for surface electrode configurations to buried electrodes. Modification of. the surface technique is accomplished by considering the additional mathematical terms required to express-the changes in the electrical potential and geometry caused by placing the source and receiver electrodes below the surface. This report presents a listing of a computer program to calculate the resistivity and induced polarization response from a three-dimensional body for buried electrode configurations. The program is designed to calculate the response for the following electrode configurations: (1) hole-to-surface array with a buried bipole source and a surface bipole receiver, (2) hole-to-surface array with a buried pole source and a surface bipole receiver, (3) hole-to-hole array with a buried, fixed pole source and a moving bipole receiver, (4) surface-to-hole array with a fixed pole source on the surface and a moving bipole receiver in the borehole, (5) hole-to-hole array with a buried, fixed bipole source and a buried, moving bipole receiver, (6) hole-to-hole array with a buried, moving bipole source and a buried, moving bipole receiver, and (7) single-hole, buried bipole-bipole array. Input and output examples are given for each of the arrays.

  11. Creation and application of three-dimensional computer-graphic animations for introduction to radiological physics and technology.

    PubMed

    Hasegawa, Tomoyuki; Kojima, Haruna; Masu, Chisato; Fukushima, Yasuhiro; Kojima, Hironori; Konokawa, Kiminori; Isobe, Tomonori; Sato, Eisuke; Murayama, Hideo; Maruyama, Koichi; Umeda, Tokuo

    2010-01-01

    Physics-related subjects are important in the educational fields of radiological physics and technology. However, conventional teaching tools, for example texts, equations, and two-dimensional figures, are not very effective in attracting the interest of students. Therefore, we have created several multimedia educational materials covering radiological physics and technology. Each educational presentation includes several segments of high-quality computer-graphic animations designed to attract students' interest. We used personal computers (PCs) and commercial software to create and compile these. Undergraduate and graduate students and teachers and related professionals contributed to the design and creation of the educational materials as part of student research. The educational materials can be displayed on a PC monitor and manipulated with popular free software. Opinion surveys conducted in undergraduate courses at Kitasato University support the effectiveness of our educational tools in helping students gain a better understanding of the subjects offered and in raising their interest.

  12. Parallel Three-Dimensional Computation of Fluid Dynamics and Fluid-Structure Interactions of Ram-Air Parachutes

    NASA Technical Reports Server (NTRS)

    Tezduyar, Tayfun E.

    1998-01-01

    This is a final report as far as our work at University of Minnesota is concerned. The report describes our research progress and accomplishments in development of high performance computing methods and tools for 3D finite element computation of aerodynamic characteristics and fluid-structure interactions (FSI) arising in airdrop systems, namely ram-air parachutes and round parachutes. This class of simulations involves complex geometries, flexible structural components, deforming fluid domains, and unsteady flow patterns. The key components of our simulation toolkit are a stabilized finite element flow solver, a nonlinear structural dynamics solver, an automatic mesh moving scheme, and an interface between the fluid and structural solvers; all of these have been developed within a parallel message-passing paradigm.

  13. Three-Dimensional Finite Element Magnetic Field Computations and Performance Simulation of Brushless DC Motor Drives with Skewed Permanent Magnet Mounts.

    NASA Astrophysics Data System (ADS)

    Alhamadi, Mohd A. Wahed

    1992-01-01

    A three dimensional finite element (3D-FE) method for the computation of global distributions of 30 magnetic fields in electric machines containing permanent magnets is presented. The formulation of this 3D-FE method is based on a coupled magnetic vector potential - magnetic scalar potential (CMVP-MSP) approach. In this CMVP-MSP method, the modeling and formulations of permanent magnet volumes, suited to first and second order MVP 3D-FE environments as well as first order MSP 3D-FE environment, are developed in this dissertation. The development of the necessary 3D-FE grids and algorithms for the application of the CMVP -MSP method to an example brushless dc motor, whose field is three dimensional due to the skewed permanent magnet mounts on its rotor, is also given here. It should be mentioned that the entire volume of the case-study machine from one end to another is considered in the global magnetic field computations. A complete set of results of application of the CMVP-MSP method to the computation of the global 3D field distributions and associated motor parameters under no-load and load conditions are presented in this dissertation. In addition, a complete simulation of the dynamic performance of the motor drive system using the parameters obtained from the 3D-FE field solutions are presented for no-load and various other load conditions. All the above mentioned results are experimentally verified by corresponding oscillograms obtained in the laboratory. These results are also compared with results obtained from motor parameters based on various 2D-FE approaches, showing that for certain types of skewed permanent magnet mounts, 3D-FE based parameters can make significant qualitative and quantitative improvements in motor-drive simulation results.

  14. Computer Algorithms and Architectures for Three-Dimensional Eddy-Current Nondestructive Evaluation. Volume 2. Chapters 1-5

    DTIC Science & Technology

    1989-01-20

    appropriate sensing coil. This computation should be done in (11), because it is very easy to integrate the exponential in (2,y). The result is to introduce...introduces another Fourier transform, so that the result is I LM =JJPL(zI6)Pm(y/6y)(,)dzdy (6 z 6 y)2 N N ,. )/_ T) sin(l 6z/2) )2sin(kby/2)2 (38)= 4...have gotten good results with simulated data at lower frequencies. I’ II . I -I I I 5. Ring Source Inverse Model The inverse algorithm developed in

  15. An efficient computational approach to characterize DSC-MRI signals arising from three-dimensional heterogeneous tissue structures.

    PubMed

    Semmineh, Natenael B; Xu, Junzhong; Boxerman, Jerrold L; Delaney, Gary W; Cleary, Paul W; Gore, John C; Quarles, C Chad

    2014-01-01

    The systematic investigation of susceptibility-induced contrast in MRI is important to better interpret the influence of microvascular and microcellular morphology on DSC-MRI derived perfusion data. Recently, a novel computational approach called the Finite Perturber Method (FPM), which enables the study of susceptibility-induced contrast in MRI arising from arbitrary microvascular morphologies in 3D has been developed. However, the FPM has lower efficiency in simulating water diffusion especially for complex tissues. In this work, an improved computational approach that combines the FPM with a matrix-based finite difference method (FDM), which we call the Finite Perturber the Finite Difference Method (FPFDM), has been developed in order to efficiently investigate the influence of vascular and extravascular morphological features on susceptibility-induced transverse relaxation. The current work provides a framework for better interpreting how DSC-MRI data depend on various phenomena, including contrast agent leakage in cancerous tissues and water diffusion rates. In addition, we illustrate using simulated and micro-CT extracted tissue structures the improved FPFDM along with its potential applications and limitations.

  16. Toward three-dimensional virtual biopsy of oral lesions through the development of a confocal endomicroscope interfaced with embedded computing

    NASA Astrophysics Data System (ADS)

    Thong, Patricia S. P.; Olivo, Malini; Movania, Muhammad M.; Tandjung, Stephanus S.; Bhuvaneswari, Ramaswamy; Seah, Hock-Soon; Lin, Feng; Qian, Kemao; Soo, Khee-Chee

    2011-07-01

    Oral lesions are conventionally diagnosed using white light endoscopy and histopathology of biopsy samples. Oral lesions are often flat and difficult to visualize under white light illumination. Moreover, histopathology is timeconsuming and there is a need to develop minimally invasive optical biopsy techniques to complement current techniques. Confocal laser endomicroscopy holds promise for virtual biopsy in disease diagnosis. This technique enables fluorescence imaging of tissue structures at microscopic resolution. We have developed a prototype real-time 3- dimensional (3D) imaging system using a laser endomicroscope interfaced with embedded computing. A Field- Programmable Gate Array computing platform has been programmed to synchronize cross-sectional image grabbing and Z-depth scanning, as well as automate acquisition of confocal image stacks. A PC was used for real-time volume rendering of the confocal image stacks. We conducted pre-clinical and pilot clinical studies to image the murine and human oral cavity. High quality volume renderings of the confocal image stacks were generated using 3D texture slicing. Tissue morphology and 3D structures could be visualized. The results demonstrate the potential of the system for diagnostic imaging of the oral cavity. This paves the way toward real-time virtual biopsy of oral lesions, with the aim to achieve same-day diagnosis in a clinical setting.

  17. Further development of a method for computing three-dimensional subsonic viscous flows in turbofan lobe mixers

    NASA Technical Reports Server (NTRS)

    Lin, S. J.; Kreskovsky, J. P.; Briley, W. R.; Mcdonald, H.

    1983-01-01

    Procedure for computing subsonic, turbulent flow in turbofan lobe mixers was extended to allow consideration of flow fields in which a swirl component of velocity may be present. Additional, an optional k-lambda turbulence model was added to the procedure. The method of specifying the initial flow field was also modified, allowing parametric specification or radial secondary flow velocities, and making it possible to consider initial flow fields which have significant inlet secondary flow vorticity. A series of example calculations was performed which demonstrate the various capabilities of the modified code. These calculations demonstrate the effects of initial secondary flows of various magnitudes, the effects of swirl, and the effects of turbulence model on the mixing process. The results of these calculations indicate that the initial secondary flows, presumed to be generated within the lobes, play a dominant role in the mixing process, and that the predicted results are relatively insensitive to the turbulence model used.

  18. Field enhancement and resonance phenomena in complex three-dimensional nanoparticles: efficient computation using the source-model technique.

    PubMed

    Ishay, Yakir; Leviatan, Yehuda; Bartal, Guy

    2014-05-15

    We present a semi-analytical method for computing the electromagnetic field in and around 3D nanoparticles (NP) of complex shape and demonstrate its power via concrete examples of plasmonic NPs that have nonsymmetrical shapes and surface areas with very small radii of curvature. In particular, we show the three axial resonances of a 3D cashew-nut and the broadband response of peanut-shell NPs. The method employs the source-model technique along with a newly developed intricate source distributing algorithm based on the surface curvature. The method is simple and can outperform finite-difference time domain and finite-element-based software tools in both its efficiency and accuracy.

  19. User's guide to SEAWAT; a computer program for simulation of three-dimensional variable-density ground-water flow

    USGS Publications Warehouse

    Guo, Weixing; Langevin, C.D.

    2002-01-01

    This report documents a computer program (SEAWAT) that simulates variable-density, transient, ground-water flow in three dimensions. The source code for SEAWAT was developed by combining MODFLOW and MT3DMS into a single program that solves the coupled flow and solute-transport equations. The SEAWAT code follows a modular structure, and thus, new capabilities can be added with only minor modifications to the main program. SEAWAT reads and writes standard MODFLOW and MT3DMS data sets, although some extra input may be required for some SEAWAT simulations. This means that many of the existing pre- and post-processors can be used to create input data sets and analyze simulation results. Users familiar with MODFLOW and MT3DMS should have little difficulty applying SEAWAT to problems of variable-density ground-water flow.

  20. Three-dimensional analysis of craniofacial bones and soft tissues in obstructive sleep apnea using cone beam computed tomography.

    PubMed

    Bruwier, Annick; Poirrier, Robert; Albert, Adelin; Maes, Nathalie; Limme, Michel; Charavet, Carole; Milicevic, Mladen; Raskin, Sylvianne; Poirrier, Anne-Lise

    2016-12-01

    A total of 154 adult patients with sleep complaints underwent a polysomnography and a craniofacial cone beam computed tomography (CBCT). OSA was defined as an apnea and hypopnea index (AHI) or an oxygen desaturation index (ODI) ≥ 10. Soft tissues and craniofacial bones volumes were prospectively measured by CBCT and collected blindly from sleep polysomnography. Among the study patients, 127 (83%) suffered from OSA and 27 (17%) did not. OSA patients demonstrated a narrower maxillo-palatine core volume (11.7±3.2 vs 14.6±4.9cm(3)) even when adjusting for age, gender, height, neck circumference and body mass index. These upper airway measures provide a comprehensive analysis of bony structures and soft tissues, which can be involved in OSA.

  1. Rotational and Translational Components of Motion Parallax: Observers' Sensitivity and Implications for Three-Dimensional Computer Graphics

    NASA Technical Reports Server (NTRS)

    Kaiser, Mary K.; Montegut, Michael J.; Proffitt, Dennis R.

    1995-01-01

    The motion of objects during motion parallax can be decomposed into 2 observer-relative components: translation and rotation. The depth ratio of objects in the visual field is specified by the inverse ratio of their angular displacement (from translation) or equivalently by the inverse ratio of their rotations. Despite the equal mathematical status of these 2 information sources, it was predicted that observers would be far more sensitive to the translational than rotational component. Such a differential sensitivity is implicitly assumed by the computer graphics technique billboarding, in which 3-dimensional (3-D) objects are drawn as planar forms (i.e., billboards) maintained normal to the line of sight. In 3 experiments, observers were found to be consistently less sensitive to rotational anomalies. The implications of these findings for kinetic depth effect displays and billboarding techniques are discussed.

  2. Computation of three-dimensional compressible boundary layers to fourth-order accuracy on wings and fuselages

    NASA Technical Reports Server (NTRS)

    Iyer, Venkit

    1990-01-01

    A solution method, fourth-order accurate in the body-normal direction and second-order accurate in the stream surface directions, to solve the compressible 3-D boundary layer equations is presented. The transformation used, the discretization details, and the solution procedure are described. Ten validation cases of varying complexity are presented and results of calculation given. The results range from subsonic flow to supersonic flow and involve 2-D or 3-D geometries. Applications to laminar flow past wing and fuselage-type bodies are discussed. An interface procedure is used to solve the surface Euler equations with the inviscid flow pressure field as the input to assure accurate boundary conditions at the boundary layer edge. Complete details of the computer program used and information necessary to run each of the test cases are given in the Appendix.

  3. A three-dimensional computational fluid dynamics model of shear stress distribution during neotissue growth in a perfusion bioreactor.

    PubMed

    Guyot, Y; Luyten, F P; Schrooten, J; Papantoniou, I; Geris, L

    2015-12-01

    Bone tissue engineering strategies use flow through perfusion bioreactors to apply mechanical stimuli to cells seeded on porous scaffolds. Cells grow on the scaffold surface but also by bridging the scaffold pores leading a fully filled scaffold following the scaffold's geometric characteristics. Current computational fluid dynamic approaches for tissue engineering bioreactor systems have been mostly carried out for empty scaffolds. The effect of 3D cell growth and extracellular matrix formation (termed in this study as neotissue growth), on its surrounding fluid flow field is a challenge yet to be tackled. In this work a combined approach was followed linking curvature driven cell growth to fluid dynamics modeling. The level-set method (LSM) was employed to capture neotissue growth driven by curvature, while the Stokes and Darcy equations, combined in the Brinkman equation, provided information regarding the distribution of the shear stress profile at the neotissue/medium interface and within the neotissue itself during growth. The neotissue was assumed to be micro-porous allowing flow through its structure while at the same time allowing the simulation of complete scaffold filling without numerical convergence issues. The results show a significant difference in the amplitude of shear stress for cells located within the micro-porous neo-tissue or at the neotissue/medium interface, demonstrating the importance of taking along the neotissue in the calculation of the mechanical stimulation of cells during culture.The presented computational framework is used on different scaffold pore geometries demonstrating its potential to be used a design as tool for scaffold architecture taking into account the growing neotissue. Biotechnol. Bioeng. 2015;112: 2591-2600. © 2015 Wiley Periodicals, Inc.

  4. Micro3D: computer program for three-dimensional reconstruction visualization, and analysis of neuronal populations and barin regions.

    PubMed

    Bjaalie, Jan G; Leergaard, Trygve B; Pettersen, Christian

    2006-04-01

    This article presents a computer program, Micro3D, designed for 3-D reconstruction, visualization, and analysis of coordinate-data (points and lines) recorded from serial sections. The software has primarily been used for studying shapes and dimension of brain regions (contour line data) and distributions of cellular elements such as neuronal cell bodies or axonal terminal fields labeled with tract-tracing techniques (point data). The tissue elements recorded could equally well be labeled with use of other techniques, the only requirement being that the data collected are saved as x,y,z coordinates. Data are typically imported from image-combining computerized microscopy systems or image analysis systems, such as Neurolucida (MicroBrightField, Colchester, VT) or analySIS (Soft Imaging System, Gmbh, Münster, Germany). System requirements are a PC running LINUX. Reconstructions in Micro3D may be rotated and zoomed in real-time, and submitted to perspective viewing and stereo-imaging. Surfaces are re-synthesized on the basis of stacks of contour lines. Clipping is used for defining section-independent subdivisions of the reconstruction. Flattening of curved sheets of points layers (e.g., neurons in a layer) facilitates inspection of complicated distribution patterns. Micro3D computes color-coded density maps. Opportunities for translation of data from different reconstructions into common coordinate systems are also provided. This article demonstrates the use of Micro3D for visualization of complex neuronal distribution patterns in somatosensory and auditory systems. The software is available for download on conditions posted at the NeSys home pages (http://www.nesys.uio.no/) and at The Rodent Brain Workbench (http://www.rbwb.org/).

  5. Three-dimensional multidetector computed tomography may aid preoperative planning of the transmanubrial osteomuscular-sparing approach to completely resect superior sulcus tumor.

    PubMed

    Saji, Hisashi; Kato, Yasufumi; Shimada, Yoshihisa; Kudo, Yujin; Hagiwara, Masaru; Matsubayashi, Jun; Nagao, Toshitaka; Ikeda, Norihiko

    2015-11-01

    The anterior transcervical-thoracic approach clearly exposes the subclavian vessels and brachial plexus. We believe that this approach is optimal when a superior sulcus tumor (SST) invades the anterior part of the thoracic inlet. However, this approach is not yet widely applied because anatomical relationships in this procedure are difficult to visualize. Three-dimensional tomography can considerably improve preoperative planning, enhance the surgeon's skill and simplify the approach to complex surgical procedures. We applied preoperative 3-dimensional multidetector computed tomography to a case where an SST had invaded the anterior part of the thoracic inlet including the clavicle, sternoclavicular joint, first rib, subclavian vessels and brachial plexus. After the patient underwent induction chemotherapy, we performed the transmanubrial osteomuscular-sparing approach and added a third anterolateral thoracotomy with a hemi-clamshell incision and completely resected the tumor.

  6. Ptosis as partial oculomotor nerve palsy due to compression by infundibular dilatation of posterior communicating artery, visualized with three-dimensional computer graphics: case report.

    PubMed

    Fukushima, Yuta; Imai, Hideaki; Yoshino, Masanori; Kin, Taichi; Takasago, Megumi; Saito, Kuniaki; Nakatomi, Hirofumi; Saito, Nobuhito

    2014-01-01

    Oculomotor nerve palsy (ONP) due to internal carotid-posterior communicating artery (PcomA) aneurysm generally manifests as partial nerve palsy including pupillary dysfunction. In contrast, infundibular dilatation (ID) of the PcomA has no pathogenic significance, and mechanical compression of the cranial nerve is extremely rare. We describe a 60-year-old woman who presented with progressive ptosis due to mechanical compression of the oculomotor nerve by an ID of the PcomA. Three-dimensional computer graphics (3DCG) accurately visualized the mechanical compression by the ID, and her ptosis was improved after clipping of the ID. ID of the PcomA may cause ONP by mechanical compression and is treatable surgically. 3DCG are effective for the diagnosis and preoperative simulation.

  7. High-resolution three-dimensional scanning transmission electron microscopy characterization of oxide-nitride-oxide layer interfaces in Si-based semiconductors using computed tomography.

    PubMed

    Sadayama, Shoji; Sekiguchi, Hiromi; Bright, Alexander; Suzuki, Naohisa; Yamada, Kazuhiro; Kaneko, Kenji

    2011-01-01

    Oxide-nitride-oxide (ONO) layer structures are widely used for charge storage in flash memory devices. The ONO layer interfaces should be as flat as possible, so measurement of the nanoscale roughness of those interfaces is needed. In this study, quantification of an ONO film from a commercially available flash memory device was carried out with a pillar-shaped specimen using scanning transmission electron microscopy (STEM) and computed tomography. The ONO area contained only low Z- and low STEM-contrast materials, which makes high-quality reconstruction difficult. The optimum three-dimensional reconstruction was achieved with an STEM annular dark-field detector inner collection angle of 32 mrad, a sample tilt range from -78° to +78° and 25 iterations for the simultaneous iterative reconstruction technique.

  8. Surgically Cured, Relapsed Pneumococcal Meningitis Due to Bone Defects, Non-invasively Identified by Three-dimensional Multi-detector Computed Tomography

    PubMed Central

    Akimoto, Takayoshi; Morita, Akihiko; Shiobara, Keiji; Hara, Makoto; Minami, Masayuki; Shijo, Katsunori; Nomura, Yasuyuki; Shigihara, Shuntaro; Haradome, Hiroki; Abe, Osamu; Kamei, Satoshi

    2016-01-01

    A 43-year-old Japanese man presented with a history of bacterial meningitis (BM). He was admitted to our department with a one-day history of headache and was diagnosed with relapse of BM based on the cerebrospinal fluid findings. The conventional imaging studies showed serial findings suggesting left otitis media, a temporal cephalocele, and meningitis. Three-dimensional multi-detector computed tomography (3D-MDCT) showed left petrous bone defects caused by the otitis media, and curative surgical treatment was performed. Skull bone structural abnormalities should be considered a cause of relapsed BM. 3D-MDCT was useful for revealing the causal minimal bone abnormality and performing pre-surgical mapping. PMID:27980270

  9. Dental application of novel finite element analysis software for three-dimensional finite element modeling of a dentulous mandible from its computed tomography images.

    PubMed

    Nakamura, Keiko; Tajima, Kiyoshi; Chen, Ker-Kong; Nagamatsu, Yuki; Kakigawa, Hiroshi; Masumi, Shin-ich

    2013-12-01

    This study focused on the application of novel finite-element analysis software for constructing a finite-element model from the computed tomography data of a human dentulous mandible. The finite-element model is necessary for evaluating the mechanical response of the alveolar part of the mandible, resulting from occlusal force applied to the teeth during biting. Commercially available patient-specific general computed tomography-based finite-element analysis software was solely applied to the finite-element analysis for the extraction of computed tomography data. The mandibular bone with teeth was extracted from the original images. Both the enamel and the dentin were extracted after image processing, and the periodontal ligament was created from the segmented dentin. The constructed finite-element model was reasonably accurate using a total of 234,644 nodes and 1,268,784 tetrahedral and 40,665 shell elements. The elastic moduli of the heterogeneous mandibular bone were determined from the bone density data of the computed tomography images. The results suggested that the software applied in this study is both useful and powerful for creating a more accurate three-dimensional finite-element model of a dentulous mandible from the computed tomography data without the need for any other software.

  10. Three-dimensional vortex methods

    SciTech Connect

    Greengard, C.A.

    1984-08-01

    Three-dimensional vortex methods for the computation of incompressible fluid flow are presented from a unified point of view. Reformulations of the filament method and of the method of Beale and Majda show them to be very similar algorithms; in both of them, the vorticity is evaluated by a discretization of the spatial derivative of the flow map. The fact that the filament method, the one which is most often used in practice, can be formulated as a version of the Beale and Majda algorithm in a curved coordinate system is used to give a convergence theorem for the filament method. The method of Anderson is also discussed, in which vorticity is evaluated by the exact differentiation of the approximate velocity field. It is shown that, in the inviscid version of this algorithm, each approximate vector of vorticity remains tangent to a material curve moving with the computed flow, with magnitude proportional to the stretching of this vortex line. This remains true even when time discretization is taken into account. It is explained that the expanding core vortex method converges to a system of equations different from the Navier-Stokes equations. Computations with the filament method of the inviscid interaction of two vortex rings are reported, both with single filaments in each ring and with a fully three-dimensional discretization of vorticity. The dependence on parameters is discussed, and convergence of the computed solutions is observed. 36 references, 4 figures.

  11. Visualizing polymeric bioresorbable scaffolds with three-dimensional image reconstruction using contrast-enhanced micro-computed tomography.

    PubMed

    Tu, Sheng; Hu, Fudong; Cai, Wei; Xiao, Liyan; Zhang, Linlin; Zheng, Hong; Jiang, Qiong; Chen, Lianglong

    2017-05-01

    There are no previous studies showing how to visualize polymeric bioresorbable scaffolds (BRSs) by micro-computed tomography (mCT). There are no previous studies showing how to visualize polymeric bioresorbable scaffolds (BRSs) by micro-computed tomography (mCT). This study aimed to explore the feasibility of detecting polymeric BRS with 3-dimensional reconstruction of BRS images by contrast-enhanced mCT and to determine the optimal imaging settings. BRSs, made of poly-L-lactic acid (PLLA), were implanted in coronary bifurcation models. Five treatments were conducted to examine an optimal condition for imaging BRSs: Baseline treatment, samples were filled with normal saline and scanned with mCT immediately; Treatment-1, -2, -3 and -4, samples were filled with contrast medium and scanned with mCT immediately and 1, 2 and 3 h thereafter, corresponding to soaking time of contrast medium of 0, 1, 2 and 3 h. Compared to Baseline, mCT scanning completely discriminate the scaffold struts from the vascular lumen immediately after filling the samples with contrast agent but not from the vascular wall until the contrast agent soaking time was more than 2 h (Treatment-3 and -4). By setting 10-15 HU as a cut-point of CT values, the scaffold strut detectable rate at Baseline and Teatment-1, -2, -3 and -4 were 1.23 ± 0.31%, 1.65 ± 0.26%, 58.14 ± 12.84%, 97.97 ± 1.43% and 98.90 ± 0.38%, respectively (Treatment-3 vs. Treatment-2, p < 0.01); meanwhile, the success rate of 3D BRS reconstruction with high quality images at Baseline and Teatment-1, -2, -3 and -4 were 1.23%, 1.65%, 58.14%, 97.97% and 98.90%, respectively (Treatment-3 vs. Treatment-2, p < 0.01). In conclusions, reconstruction of 3D BRS images is technically feasible by contrast-enhanced mCT and soaking time of contrast agent for more than 2 h is necessary for complete separation of scaffold struts from the surrounding structures in the phantom samples.

  12. Three-dimensional metamaterials

    SciTech Connect

    Burckel, David Bruce

    2012-06-12

    A fabrication method is capable of creating canonical metamaterial structures arrayed in a three-dimensional geometry. The method uses a membrane suspended over a cavity with predefined pattern as a directional evaporation mask. Metallic and/or dielectric material can be evaporated at high vacuum through the patterned membrane to deposit resonator structures on the interior walls of the cavity, thereby providing a unit cell of micron-scale dimension. The method can produce volumetric metamaterial structures comprising layers of such unit cells of resonator structures.

  13. Three dimensional quantum chromodynamics

    NASA Astrophysics Data System (ADS)

    Ferretti, G.; Rajeev, S. G.; Yang, Z.

    1992-02-01

    The subject of this talk is the study of the low energy behavior of three (2+1) dimensional Quantum Chromodynamics. We show the existence of a phase where parity is unbroken and the flavor group U(2n) is broken into a subgroup U(n)×U(n). We derive the low energy effective action for the theory and show that it has solitonic excitations with Fermi statistic, to be identified with the three dimensional ``baryon''. Finally, we study the current algebra for this effective action and we find a co-homologically nontrivial generalization of Kac-Moody algebras to three dimension.

  14. Spiral computed tomographic scanning of the chest with three dimensional imaging in the diagnosis and management of paediatric intrathoracic airway obstruction.

    PubMed Central

    Sagy, M.; Poustchi-Amin, M.; Nimkoff, L.; Silver, P.; Shikowitz, M.; Leonidas, J. C.

    1996-01-01

    BACKGROUND: The usefulness of spiral computed tomographic (CT) scans of the chest with three dimensional imaging (3D-CT) of intrathoracic structures in the diagnosis and management of paediatric intrathoracic airway obstruction was assessed. METHODS: A retrospective review was made of five consecutive cases (age range six months to four years) admitted to the paediatric intensive care unit and paediatric radiology division of a tertiary care children's hospital with severe respiratory decompensation suspected of being caused by intrathoracic large airway obstruction. Under adequate sedation, the patients underwent high speed spiral CT scanning of the thorax. Non-ionic contrast solution was injected in two patients to demonstrate the anatomical relationship between the airway and the intrathoracic large vessels. Using computer software, three-dimensional images of intrathoracic structures were then reconstructed by the radiologist. RESULTS: In all five patients the imaging results were useful in directing the physician to the correct diagnosis and appropriate management. In one patient, who had undergone repair of tetralogy of Fallot with absent pulmonary valve, the 3D-CT image showed bilateral disruptions in the integrity of the tracheobronchial tree due to compression by a dilated pulmonary artery. This patient underwent pulmonary artery aneurysmorrhaphy and required continued home mechanical ventilation via tracheostomy. In three other patients with symptoms of lower airway obstruction the 3D-CT images showed significant stenosis in segments of the tracheobronchial tree in two of them, and subsequent bronchoscopy established a diagnosis of segmental bronchomalacia. These two patients required mechanical ventilation and distending pressure to relieve their bronchospasm. In another patient who had undergone surgical repair of intrathoracic tracheal stenosis three years prior to admission the 3D-CT scan ruled out restenosis as the reason for her acute respiratory

  15. Implementation of a computationally efficient least-squares algorithm for highly under-determined three-dimensional diffuse optical tomography problems

    PubMed Central

    Yalavarthy, Phaneendra K.; Lynch, Daniel R.; Pogue, Brian W.; Dehghani, Hamid; Paulsen, Keith D.

    2008-01-01

    Three-dimensional (3D) diffuse optical tomography is known to be a nonlinear, ill-posed and sometimes under-determined problem, where regularization is added to the minimization to allow convergence to a unique solution. In this work, a generalized least-squares (GLS) minimization method was implemented, which employs weight matrices for both data-model misfit and optical properties to include their variances and covariances, using a computationally efficient scheme. This allows inversion of a matrix that is of a dimension dictated by the number of measurements, instead of by the number of imaging parameters. This increases the computation speed up to four times per iteration in most of the under-determined 3D imaging problems. An analytic derivation, using the Sherman–Morrison–Woodbury identity, is shown for this efficient alternative form and it is proven to be equivalent, not only analytically, but also numerically. Equivalent alternative forms for other minimization methods, like Levenberg–Marquardt (LM) and Tikhonov, are also derived. Three-dimensional reconstruction results indicate that the poor recovery of quantitatively accurate values in 3D optical images can also be a characteristic of the reconstruction algorithm, along with the target size. Interestingly, usage of GLS reconstruction methods reduces error in the periphery of the image, as expected, and improves by 20% the ability to quantify local interior regions in terms of the recovered optical contrast, as compared to LM methods. Characterization of detector photomultiplier tubes noise has enabled the use of the GLS method for reconstructing experimental data and showed a promise for better quantification of target in 3D optical imaging. Use of these new alternative forms becomes effective when the ratio of the number of imaging property parameters exceeds the number of measurements by a factor greater than 2. PMID:18561643

  16. Comparison of in vivo cone-beam and multidetector computed tomographic scans by three-dimensional merging software.

    PubMed

    Rostetter, Claudio; Metzler, Philipp; Schenkel, Jan S; Seifert, Burkhardt; Luebbers, Heinz-Theo

    2015-12-01

    In dentomaxillofacial radiology, cone-beam computed tomography (CT) is used to give fast and high-resolution 3-dimensional images of bone with a low dose of radiation. However, its use for quantitative measurement of bone density based on absolute values (Hounsfield units, HU) as in multidetector CT is still controversial. We know of no in vivo study of 3-dimensional merging software that will reliably match identical bone areas of cone-beam and multidetector CT datasets. We studied 19 multidetector, and 19 cone-beam, CT scans of the skull. The two datasets were fused, corresponding points were identified for measurement, and we compared mean density. We used linear regression to analyse the relation between the two different scanning methods, and studied a total of 4180 measurements. The mean time interval between scans was 5.2 (4.7) months. Mean R(2) over all measurements was 0.63 (range 0.22 - 0.79) with a mean internal consistency (Cronbach's α) of 0.86 (range 0.61 - 0.93). The strongest linearity, seen at the left mastoid, was R(2)=0.79 with high internal consistency (Cronbach's α 0.89), and the weakest was at the left zygomatic bone with R(2)=0.22 and Cronbach's α=0.61. Measurements of bone density based on cone-beam and multidetector CT scans generated in vivo showed high and reproducible internal consistency but poor linearity.

  17. Reproducibility of Global and Local Reconstruction of Three-Dimensional Micro-Computed Tomography of Iliac Crest Biopsies

    SciTech Connect

    Jorgensen,S.; Eaker, D.; Vercnocke, A.; Ritman, E.

    2008-01-01

    Variation in computed tomography (CT) image grayscale and spatial geometry due to specimen orientation, magnification, voxel size, differences in X-ray photon energy and limited field-of-view during the scan, were evaluated in repeated micro-CT scans of iliac crest biopsies and test phantoms. Using the micro-CT scanner on beamline X2B at the Brookhaven National Laboratory's National Synchrotron Light Source, 3-D micro-CT images were generated. They consisted of up to 1024 X 24002, 4-mum cubic voxels, each with 16-bit gray-scale. We also reconstructed the images at 16-, 32-, and 48-mum voxel resolution. Scan data were reconstructed from the complete profiles using filtered back-projection and from truncated profiles using profile-extension and with a Local reconstruction algorithm. Three biopsies and one bonelike test phantom were each rescanned at three different times at annual intervals. For the full-data-set reconstructions, the reproducibility of the estimates of mineral content of bone at mean bone opacity value, was {+-}28.8 mg/cm3, i.e., 2.56%, in a 4-mum cubic voxel at the 95% confidence level. The reproducibility decreased with increased voxel size. The interscan difference in imaged bone volume ranged from 0.86 {+-} 0.64% at 4-mum voxel resolution, and 2.64 {+-} 2.48% at 48 mum.

  18. Three-dimensional imaging of human hippocampal tissue using synchrotron radiation- and grating-based micro computed tomography

    NASA Astrophysics Data System (ADS)

    Hieber, Simone E.; Khimchenko, Anna; Kelly, Christopher; Mariani, Luigi; Thalmann, Peter; Schulz, Georg; Schmitz, Rüdiger; Greving, Imke; Dominietto, Marco; Müller, Bert

    2014-09-01

    Hippocampal sclerosis is a common cause of epilepsy, whereby a neuronal cell loss of more than 50% cells is characteristic. If medication fails the best possible treatment is the extraction of the diseased organ. To analyze the microanatomy of the diseased tissue we scanned a human hippocampus extracted from an epilepsy patient. After the identification of degenerated tissue using magnetic resonance imaging the specimen was reduced in size to fit into a cylindrical container with a diameter of 6 mm. Using synchrotron radiation and grating interferometry we acquired micro computed tomography datasets of the specimen. The present study was one of the first successful phase tomography measurements at the imaging beamline P05 (operated by HZG at the PETRA III storage ring, DESY, Hamburg, Germany). Ring and streak artefacts were reduced by enhanced flat-field corrections, combined wavelet-Fourier filters and bilateral filtering. We improved the flat-field correction by the consideration of the correlation between the projections and the flat-field images. In the present study, the correlation that was based on mean squared differences and evaluated on manually determined reference regions leads to the best artefact reduction. A preliminary segmentation of the abnormal tissue reveals that a clinically relevant study requires the development of even more sophisticated artifact reduction tools or a phase contrast measurement of higher quality.

  19. Natural and laboratory compaction bands in porous carbonates: a three-dimensional characterization using synchrotron X-ray computed microtomography

    NASA Astrophysics Data System (ADS)

    Cilona, A.; Arzilli, F.; Mancini, L.; Emanuele, T.

    2014-12-01

    Porous carbonates form important reservoirs for water and hydrocarbons. The fluid flow properties of carbonate reservoirs may be affected by post-depositional processes (e.g., mechanical and chemical), which need to be quantified. Field-based studies described bed-parallel compaction bands (CBs) within carbonates with a wide range of porosities. These burial-related structures accommodate volumetric strain by grain rotation, translation, pore collapse and pressure solution. Recently, the same structures have been reproduced for the first time in the laboratory by performing triaxial compaction experiments on porous grainstones. These laboratory studies characterized and compared the microstructures of natural and laboratory CBs, but no analysis of pore connectivity has been performed. In this paper, we use an innovative approach to characterize the pore networks (e.g. porosity, connectivity) of natural and laboratory CBs and compare them with the host rock one. We collected the data using the synchrotron X-ray computed microtomography technique at the SYRMEP beamline of the Elettra-Sincrotrone Trieste Laboratory (Italy). Quantitative analyses of the samples were performed with the Pore3D software library. The porosity was calculated from segmented 3D images of pristine and deformed carbonates. A process of skeletonization was then applied to quantify the number of connected pores within the rock volume. The analysis of the skeleton allowed us to highlight the differences between natural and laboratory CBs, and to investigate how pore connectivity evolves as a function of different deformation pathways. Both pore volume and connectivity are reduced within the CBs respect to the pristine rock and the natural CB has a lower porosity with respect to the laboratory one. The grain contacts in the natural CB are welded, whereas in the laboratory one they have more irregular shapes and grain crushing is the predominant process.

  20. Advanced Computer Typography.

    DTIC Science & Technology

    1981-12-01

    ADVANCED COMPUTER TYPOGRAPHY .(U) DEC 81 A V HERSHEY UNCLASSIFIED NPS012-81-005 M MEEEIEEEII IIUJIL15I.4 MICROCQP RE SO.JjI ON ft R NPS012-81-005...NAVAL POSTGRADUATE SCHOOL 0Monterey, California DTIC SELECTEWA APR 5 1982 B ADVANCED COMPUTER TYPOGRAPHY by A. V. HERSHEY December 1981 OApproved for...Subtitle) S. TYPE Or REPORT & PERIOD COVERED Final ADVANCED COMPUTER TYPOGRAPHY Dec 1979 - Dec 1981 S. PERFORMING ORG. REPORT NUMBER 7. AUTHOR(s) S CONTRACT

  1. Quasicrystalline three-dimensional foams

    NASA Astrophysics Data System (ADS)

    Cox, S. J.; Graner, F.; Mosseri, R.; Sadoc, J.-F.

    2017-03-01

    We present a numerical study of quasiperiodic foams, in which the bubbles are generated as duals of quasiperiodic Frank–Kasper phases. These foams are investigated as potential candidates to the celebrated Kelvin problem for the partition of three-dimensional space with equal volume bubbles and minimal surface area. Interestingly, one of the computed structures falls close to (but still slightly above) the best known Weaire–Phelan periodic candidate. In addition we find a correlation between the normalized bubble surface area and the root mean squared deviation of the number of faces, giving an additional clue to understanding the main geometrical ingredients driving the Kelvin problem.

  2. Three Dimensional Dirac Semimetals

    NASA Astrophysics Data System (ADS)

    Zaheer, Saad

    2014-03-01

    Dirac points on the Fermi surface of two dimensional graphene are responsible for its unique electronic behavior. One can ask whether any three dimensional materials support similar pseudorelativistic physics in their bulk electronic spectra. This possibility has been investigated theoretically and is now supported by two successful experimental demonstrations reported during the last year. In this talk, I will summarize the various ways in which Dirac semimetals can be realized in three dimensions with primary focus on a specific theory developed on the basis of representations of crystal spacegroups. A three dimensional Dirac (Weyl) semimetal can appear in the presence (absence) of inversion symmetry by tuning parameters to the phase boundary separating a bulk insulating and a topological insulating phase. More generally, we find that specific rules governing crystal symmetry representations of electrons with spin lead to robust Dirac points at high symmetry points in the Brillouin zone. Combining these rules with microscopic considerations identifies six candidate Dirac semimetals. Another method towards engineering Dirac semimetals involves combining crystal symmetry and band inversion. Several candidate materials have been proposed utilizing this mechanism and one of the candidates has been successfully demonstrated as a Dirac semimetal in two independent experiments. Work carried out in collaboration with: Julia A. Steinberg, Steve M. Young, J.C.Y. Teo, C.L. Kane, E.J. Mele and Andrew M. Rappe.

  3. Electroholographic display unit for three-dimensional display by use of special-purpose computational chip for holography and reflective LCD panel.

    PubMed

    Shimobaba, Tomoyoshi; Shiraki, Atsushi; Masuda, Nobuyuki; Ito, Tomoyoshi

    2005-05-30

    We developed an electroholography unit, which consists of a special-purpose computational chip for holography and a reflective liquid-crystal display (LCD) panel, for a three-dimensional (3D) display. The special-purpose chip can compute a computer-generated hologram of 800x600 grids in size from a 3D object consisting of approximately 400 points in approximately 0.15 seconds. The pixel pitch and resolution of the LCD panel are 12 mum and 800x600 grids, respectively. We implemented the special purpose chip and LCD panel on a printed circuit board of approximately 28cmx13cm in size. After the calculation, the computer-generated hologram produced by the special-purpose chip is displayed on the LCD panel. When we illuminate a reference light to the LCD panel, we can observe a 3D animation of approximately 3cmx3cmx3cm in size. In the present paper, we report the electroholographic display unit together with a simple 3D display system.

  4. Short-term pharyngeal airway changes after mandibular advancement surgery in adult Class II-Patients--a three-dimensional retrospective study.

    PubMed

    Kochel, Janka; Meyer-Marcotty, Philipp; Sickel, Franka; Lindorf, Helmut; Stellzig-Eisenhauer, Angelika

    2013-03-01

    The purpose of this study was to investigate volume changes in posterior airway space (PAS) after bilateral mandibular advancement surgery. Measurements were taken based on three-dimensional (3D) records available for a large and homogeneous cohort of patients. Pre- and postoperative CBCT scans of 102 adult patients with Class II dysgnathia were visualized and analyzed using 3D software (Mimics® Innovation Suite 14.1; Materialise, Leuven, Belgium). The PAS was divided into three segments by three planes parallel and one plane perpendicular to the Frankfort horizontal plane. Total volume, partial volumes, and cross-sectional areas were calculated from the pre- and postoperative scans. Dahlberg coefficients were obtained to verify each parameter for the measurements' reliability. The statistical significance of the changes observed was analyzed by Wilcoxon's rank-sum test. Highly significant (p=0.000) increases in total posterior airway volume (+32.0%) were noted as an effect of mandibular advancement surgery, amounting to 45.6% in the lower PAS third compared to 38.8% in the middle and 12.5% in the upper PAS third. We also obtained highly significant (p=0.000) increases in all the cross-sectional areas investigated, amounting to 48.5% on the soft-palate level compared to 21.6% on the level of the epiglottis tip, and 14.6% on the hard-palate level. These results demonstrate that bilateral mandibular advancement surgery in Class II-Patients leads to significant increases in PAS volume and significant widening of the narrower sites inside the pharynx.

  5. Technical note: Three-dimensional imaging of rumen tissue for morphometric analysis using micro-computed tomography.

    PubMed

    Steele, M A; Garcia, F; Lowerison, M; Gordon, K; Metcalf, J A; Hurtig, M

    2014-12-01

    Rumen development in calves has been evaluated by measuring papillae length, width, and density using microscopy for over 50 yr. Although common in the literature, disadvantages to this method exist, such as large variations in rumen papillae size and shape, small numbers of total papillae being measured, and the time required. The objective of this study was to develop a more effective technique for assessing rumen papillae using micro-computed tomography (micro-CT) and to compare this technique with microscopy. Rumen tissue was collected from the ventral sac of 20 postweaned bull calves at 55 d of age, immediately fixed in 10% neutral buffered formalin for 48 h, and stored in 70% ethanol at 4°C before the contrast enhancement. After evaluation of contrast-enhancement protocols, it was determined that mercury chloride provided the most pronounced contrast for accurate micro-CT imaging based on relative density of the papillae. A 1-cm(2) tissue section from the ventral sac of all bull calves was tensioned on a rapid prototyped curved plastic holder and imaged at 4 5 μm resolution for 56 min using a GE Locus Explore micro-CT (General Electric, Milwaukee, WI). MicroView V2.2 software (General Electric) was used to create a 3-dimensional virtual model of the entire sample. The length and width of papillae were measured 3-dimensionally and compared with measurements of papillae under the light microscope taken from the same region. The length and width measurements using micro-CT (2.47 ± 0.12 and 0.55 ± 0.01 mm) compared with light microscope (2.96 ± 0.03 and 0.86 ± 0.01 mm) were significantly smaller. The difference may reflect a more accurate determination in the base of the rumen tissue with micro-CT or the specificity of mercury chloride to bind only to intact rumen tissue. The mean number of papillae per centimeter squared viewed using micro-CT was 128.5 ± 33.9 with a total surface area of 681.8 ± 112.4 mm(2) and volume of 156 mm(3) per sample. Micro

  6. On-Line Use of Three-Dimensional Marker Trajectory Estimation From Cone-Beam Computed Tomography Projections for Precise Setup in Radiotherapy for Targets With Respiratory Motion

    SciTech Connect

    Worm, Esben S.; Hoyer, Morten; Fledelius, Walther; Nielsen, Jens E.; Larsen, Lars P.; Poulsen, Per R.

    2012-05-01

    Purpose: To develop and evaluate accurate and objective on-line patient setup based on a novel semiautomatic technique in which three-dimensional marker trajectories were estimated from two-dimensional cone-beam computed tomography (CBCT) projections. Methods and Materials: Seven treatment courses of stereotactic body radiotherapy for liver tumors were delivered in 21 fractions in total to 6 patients by a linear accelerator. Each patient had two to three gold markers implanted close to the tumors. Before treatment, a CBCT scan with approximately 675 two-dimensional projections was acquired during a full gantry rotation. The marker positions were segmented in each projection. From this, the three-dimensional marker trajectories were estimated using a probability based method. The required couch shifts for patient setup were calculated from the mean marker positions along the trajectories. A motion phantom moving with known tumor trajectories was used to examine the accuracy of the method. Trajectory-based setup was retrospectively used off-line for the first five treatment courses (15 fractions) and on-line for the last two treatment courses (6 fractions). Automatic marker segmentation was compared with manual segmentation. The trajectory-based setup was compared with setup based on conventional CBCT guidance on the markers (first 15 fractions). Results: Phantom measurements showed that trajectory-based estimation of the mean marker position was accurate within 0.3 mm. The on-line trajectory-based patient setup was performed within approximately 5 minutes. The automatic marker segmentation agreed with manual segmentation within 0.36 {+-} 0.50 pixels (mean {+-} SD; pixel size, 0.26 mm in isocenter). The accuracy of conventional volumetric CBCT guidance was compromised by motion smearing ({<=}21 mm) that induced an absolute three-dimensional setup error of 1.6 {+-} 0.9 mm (maximum, 3.2) relative to trajectory-based setup. Conclusions: The first on-line clinical use of

  7. Recent developments in three-dimensional numerical estuarine models

    USGS Publications Warehouse

    Cheng, Ralph T.; Smith, Peter E.; Casulli, Vincenzo

    1993-01-01

    For a fixed cost, computing power increases 5 to 10 times every five years. The readily available computing resources have inspired new modal formulations and innovative model applications. Significant progress has been advanced in three-dimensional numerical estuarine modeling within the past three or four years. This paper attempts to review and summarize properties of new 3-D estuarine hydrodynamic models. The emphasis of the review is placed on the formulation, numerical methods. The emphasis of the review is placed on the formulation, numerical methods, spatial and temporal resolution, computational efficiency, and turbulence closure of new models. Recent research has provided guidelines for the proper use of 3-D models involving in the σ-transformation. Other models resort to a fixed level discretization in the vertical. The semi-implicit treatment in time-stepping models appears to have gained momentum. Future research in three-dimensional numerical modeling remains to be on computational efficiency and turbulent closure.

  8. A Preliminary Three-Dimensional Analysis of Nasal Aesthetics Following Le Fort I Advancement in Patients With Cleft Lip and Palate.

    PubMed

    Davidson, Edward; Kumar, Anand R

    2015-10-01

    Nasal aesthetic changes after cleft orthognathic surgery remain understudied. Previous scarring associated with prior cleft surgery may affect the predictability of outcomes after jaw surgery. This study evaluates changes in nasal aesthetics using three-dimensional photography after Le Fort I advancement in patients with nonsyndromic cleft-related maxillary hypoplasia. Cephalometric parameters were recorded pre- and postoperatively. Three-dimensional photogrammetric imaging analyzed changes in interalar width (IAW), internostril width (INW), nasal tip projection (NTP), collumelar length (CL), nasal labial angle (NLA), and nasal length (NL). Statistical significance between pre- and postoperative data was determined using T-tests for each parameter. Eleven patients underwent either single piece Le Fort I osteotomy and advancement, (3 bilateral, 4 unilateral cleft lip, and palate), or 2-piece advancement (2 bilateral, 2 unilateral). Average nasal soft tissue changes were IAW 1.9 mm (0.4-4.2), INW -0.2 mm (-2.8 to 1.6), NTP -1.0 mm (-4.0 to 2.0), CL -0.7 mm (-2.9 to 1.5), NLA -0.2° (-13.9 to 15.1), and NL -0.7 mm (-4.3 to 1.5), (P = 0.001, 0.6, 0.08, 0.01, 0.9, 0.2). For single-piece osteotomy alone changes were IAW 2.1 mm (0.6-4.1), INW -0.6 mm (-2.8 to 1.7), NTP -1.9 mm (-4.0 to 0.3), CL -1.2 mm (-2.9 to 0.03), NLA -1.3° (-13.9 to 15.0), and NL -1.1 mm (-4.3 to 0.7), (P = 0.007, 0.3, 0.009, 0.0002, 0.7, 0.2). For 2-piece osteotomy alone changes were IAW 1.6 mm (-0.4 to 3.3), INW 0.5 mm (0.4-1.6), NTP 0.5 mm (-1.1-2.0), CL 0.2 mm (-1.4 to 1.5), NLA 2.8° (-7.6 to 10.1), and NL -0.1 mm (-1.4 to 1.5), (P = 0.2, 0.4, 0.5, 0.6, 0.5, 0.9). Cleft-related scarring and malposition affect changes in nasal aesthetics following maxillary advancement that are different to the noncleft population. Two-piece Le Fort I increases variability of changes in nasal aesthetics compared with single-piece advancement.

  9. Monitoring the response to neoadjuvant hormone therapy for locally advanced breast cancer using three-dimensional time-resolved optical mammography

    NASA Astrophysics Data System (ADS)

    Enfield, Louise; Cantanhede, Gabriel; Douek, Michael; Ramalingam, Vernie; Purushotham, Arnie; Hebden, Jem; Gibson, Adam

    2013-05-01

    Optical mammography is a functional imaging technique that uses near-infrared light to produce three-dimensional breast images of tissue oxygen saturation and hemoglobin concentration. It has been used to monitor the response to neoadjuvant chemotherapy in breast cancer patients. We present the first results on monitoring tumor response to hormone therapy using optical mammography. We present three case studies from postmenopausal women treated with neoadjuvant hormone therapy for locally advanced breast cancer. The women were scanned before starting treatment, once during treatment, and then before surgery. Changes in physiological and optical properties within the tumor and in the rest of the breast were evaluated. At the time of surgery, two patients partially responded to treatment and one did not respond. The patients that partially responded on ultrasound revealed a corresponding recovery to normal in the hemoglobin concentration images, whereas the nonresponder indicated an increase in hemoglobin concentration in the tumor compared to her pretreatment images. These case studies suggest that optical imaging of the breast during neoadjuvant hormone treatment can provide potentially valuable information, and that physiological changes within the tumor can be seen in response to treatment.

  10. A novel integration of three-dimensional electro-Fenton and biological activated carbon and its application in the advanced treatment of biologically pretreated Lurgi coal gasification wastewater.

    PubMed

    Hou, Baolin; Han, Hongjun; Zhuang, Haifeng; Xu, Peng; Jia, Shengyong; Li, Kun

    2015-11-01

    A novel integrated process with three-dimensional electro-Fenton (3D EF) and biological activated carbon (BAC) was employed in advanced treatment of biologically pretreated Lurgi coal gasification wastewater. SAC-Fe (sludge deserved activated carbon from sewage and iron sludge) and SAC (sludge deserved activated carbon) were used in 3D EF as catalytic particle electrodes (CPEs) and in BAC as carriers respectively. Results indicated that 3D EF with SAC-Fe as CPEs represented excellent pollutants and COLOR removals as well as biodegradability improvement. The efficiency enhancement attributed to generating more H2O2 and OH. The integrated process exhibited efficient performance of COD, BOD5, total phenols, TOC, TN and COLOR removals at a much shorter retention time, with the corresponding concentrations in effluent of 31.18, 6.69, 4.29, 17.82, 13.88mg/L and <20 times, allowing discharge criteria to be met. The integrated system was efficient, cost-effective and ecological sustainable and could be a promising technology for engineering applications.

  11. Pulmonary adenocarcinomas presenting as ground-glass opacities on multidetector CT: three-dimensional computer-assisted analysis of growth pattern and doubling time

    PubMed Central

    Borghesi, Andrea; Farina, Davide; Michelini, Silvia; Ferrari, Matteo; Benetti, Diego; Fisogni, Simona; Tironi, Andrea; Maroldi, Roberto

    2016-01-01

    PURPOSE We aimed to evaluate the growth pattern and doubling time (DT) of pulmonary adenocarcinomas exhibiting ground-glass opacities (GGOs) on multidetector computed tomography (CT). METHODS The growth pattern and DT of 22 pulmonary adenocarcinomas exhibiting GGOs were retrospectively analyzed using three-dimensional semiautomatic software. Analysis of each lesion was based on calculations of volume and mass changes and their respective DTs throughout CT follow-up. Three-dimensional segmentation was performed by a single radiologist on each CT scan. The same observer and another radiologist independently repeated the segmentation at the baseline and the last CT scan to determine the variability of the measurements. The relationships among DTs, histopathology, and initial CT features of the lesions were also analyzed. RESULTS Pulmonary adenocarcinomas presenting as GGOs exhibited different growth patterns: some lesions grew rapidly and some grew slowly, whereas others alternated between periods of growth, stability, or shrinkage. A significant increase in volume and mass that exceeded the coefficient of repeatability of interobserver variability was observed in 72.7% and 84.2% of GGOs, respectively. The volume-DTs and mass-DTs were heterogeneous throughout the follow-up CT scan (range, −4293 to 21928 and −3113 to 17020 days, respectively), and their intra- and interobserver variabilities were moderately high. The volume-DTs and mass-DTs were not correlated with the initial CT features of GGOs; however, they were significantly shorter in invasive adenocarcinomas (P = 0.002 and P = 0.001, respectively). CONCLUSION Pulmonary adenocarcinomas exhibiting GGOs show heterogeneous growth patterns with a trend toward a progressive increase in size. DTs may be useful for predicting tumor aggressiveness. PMID:27682741

  12. Computational investigation of the Lewis acidity in three-dimensional and corresponding two-dimensional zeolites: UTL vs IPC-1P.

    PubMed

    Thang, Ho Viet; Rubeš, Miroslav; Bludský, Ota; Nachtigall, Petr

    2014-09-04

    The adsorption and catalytic properties of three-dimensional zeolite UTL were investigated computationally along with properties of its two-dimensional analogue IPC-1P that can be obtained from UTL by a removal of D4R units. Adsorption properties and Lewis acidity of extra-framework Li(+) sites were investigated for both two- and three-dimensional forms of UTL using the carbon monoxide as a probe molecule. The CO adsorption enthalpies, calculated with various dispersion-corrected DFT methods, including DFT/CC, DFT-D2, and vdW-DF2, and the CO stretching frequencies obtained with the νCO/rCO correlation method are compared for corresponding Li(+) sites in 3D and 2D UTL zeolite. For the majority of framework Al positions the Li(+) cation is preferably located in one of the channel wall sites and such sites remains unchanged upon the 3D → 2D UTL transformation; consequently, the adsorption enthalpies become only slightly smaller in 2D UTL (less than 3 kJ mol(-1)) due to the missing part of dispersion interactions and νCO becomes also only up to 5 cm(-1) smaller in 2D UTL due to the missing repulsion with framework oxygen atoms from the opposite site of the zeolite channel (effect from the top). However, when Li(+) is located in the intersection site in 3D UTL (about 20% probability), its coordination with the framework is significantly increased in 2D UTL and that is accompanied by significant decrease of both νCO (about 20 cm(-1)) and adsorption enthalpy (about 20 kJ mol(-1)). Because the intersection sites in 3D UTL are the most active adsorption and catalytic Lewis sites, the results reported herein suggest that the 3D → 2D transformation of UTL zeolite is connected with partial decrease of zeolite activity in processes driven by Lewis acid sites.

  13. A mathematical model and computational framework for three-dimensional chondrocyte cell growth in a porous tissue scaffold placed inside a bi-directional flow perfusion bioreactor.

    PubMed

    Shakhawath Hossain, Md; Bergstrom, D J; Chen, X B

    2015-12-01

    The in vitro chondrocyte cell culture for cartilage tissue regeneration in a perfusion bioreactor is a complex process. Mathematical modeling and computational simulation can provide important insights into the culture process, which would be helpful for selecting culture conditions to improve the quality of the developed tissue constructs. However, simulation of the cell culture process is a challenging task due to the complicated interaction between the cells and local fluid flow and nutrient transport inside the complex porous scaffolds. In this study, a mathematical model and computational framework has been developed to simulate the three-dimensional (3D) cell growth in a porous scaffold placed inside a bi-directional flow perfusion bioreactor. The model was developed by taking into account the two-way coupling between the cell growth and local flow field and associated glucose concentration, and then used to perform a resolved-scale simulation based on the lattice Boltzmann method (LBM). The simulation predicts the local shear stress, glucose concentration, and 3D cell growth inside the porous scaffold for a period of 30 days of cell culture. The predicted cell growth rate was in good overall agreement with the experimental results available in the literature. This study demonstrates that the bi-directional flow perfusion culture system can enhance the homogeneity of the cell growth inside the scaffold. The model and computational framework developed is capable of providing significant insight into the culture process, thus providing a powerful tool for the design and optimization of the cell culture process.

  14. Three-dimensional vortex methods

    NASA Astrophysics Data System (ADS)

    Greengard, C. A.

    1984-08-01

    Reformulations of the filament method and of the method of Beale and Majda show them to be very similar algorithms. The method of Anderson in which vorticity is evaluated by the exact differentiation of the approximate velocity field is discussed. It is shown that, in the inviscid version of this algorithm, each approximate vector of vorticity remains tangent to a material curve moving with the computed flow, with magnitude proportional to the stretching of this vortex line. It is explained that the expanding core vortex method converges to a system of equations different from the Navier-Stokes equations. Computations with the filament method of the inviscid interaction of two vortex rings are reported, both with single filaments in each ring and with a fully three-dimensional discretization of vorticity. The dependence on parameters is discussed, and convergence of the computed solutions is observed.

  15. Three dimensional interactive display

    NASA Technical Reports Server (NTRS)

    Vranish, John M. (Inventor)

    2005-01-01

    A three-dimensional (3-D) interactive display and method of forming the same, includes a transparent capaciflector (TC) camera formed on a transparent shield layer on the screen surface. A first dielectric layer is formed on the shield layer. A first wire layer is formed on the first dielectric layer. A second dielectric layer is formed on the first wire layer. A second wire layer is formed on the second dielectric layer. Wires on the first wire layer and second wire layer are grouped into groups of parallel wires with a turnaround at one end of each group and a sensor pad at the opposite end. An operational amplifier is connected to each of the sensor pads and the shield pad biases the pads and receives a signal from connected sensor pads in response to intrusion of a probe. The signal is proportional to probe location with respect to the monitor screen.

  16. Effects of docetaxel plus three-dimensional conformal radiation therapy on microvessel density and apoptosis expression in local advanced squamous non-small-cell lung cancer.

    PubMed

    Zhai, X J; Cheng, H R; Long, H L; Mao, W K; Cao, L; Xiao, B R; Li, R Q

    2015-05-22

    We examined the effects of weekly single-agent docetaxel plus three-dimensional conformal radiation therapy (3D-CRT) on apoptotic index (AI) and microvessel density (MVD) in local advanced non-small-cell lung squamous cancer patients and analyzed the correlation of MVD, AI, and 50% tumor shrinkage time (T0.5) The molecular mechanism of docetaxel radiosensitization was investigated. Sixty untreated patients with stage IIIA or IIIB lung squamous cancer were enrolled and randomly divided into two groups: observation (N = 30; 3D-CRT + docetaxel + adjuvant chemotherapy) and control (N = 30; 3D-CRT + adjuvant chemotherapy). From day 1 radiotherapy, the observation group received intravenous docetaxel (36 mg/m(2)) once weekly for 6 weeks. Post-radiotherapy, chemotherapy of docetaxel combined with cisplatin lasted 4-6 cycles in both groups. Before radiotherapy and within 24 h after radiotherapy (20 Gy), bronchoscopic biopsy was performed twice at the same site. To analyze the MVD of tumor specimens with immunohistochemical staining . The AI of lung cancer cells was assessed with TUNEL assay, T0.5 values were calculated. The observation group had significantly lower MVD than the control group (P < 0.05). AI significantly increased before and after treatment in the observation group compared with the control group (P < 0.05). The decreased MVD values negatively correlated with T0.5 values (r = -0.624, P < 0.05), whereas the increased AI values did not correlate with the T0.5 values. Docetaxel radiosensitization may occur by decrease in MVD and increase in AI values. Weekly single-agent docetaxel plus 3D-CRT can improve prognosis and quality of life in local advanced non-small-cell lung squamous cancer patients.

  17. Three-dimensional printing physiology laboratory technology

    PubMed Central

    Sulkin, Matthew S.; Widder, Emily; Shao, Connie; Holzem, Katherine M.; Gloschat, Christopher; Gutbrod, Sarah R.

    2013-01-01

    Since its inception in 19th-century Germany, the physiology laboratory has been a complex and expensive research enterprise involving experts in various fields of science and engineering. Physiology research has been critically dependent on cutting-edge technological support of mechanical, electrical, optical, and more recently computer engineers. Evolution of modern experimental equipment is constrained by lack of direct communication between the physiological community and industry producing this equipment. Fortunately, recent advances in open source technologies, including three-dimensional printing, open source hardware and software, present an exciting opportunity to bring the design and development of research instrumentation to the end user, i.e., life scientists. Here we provide an overview on how to develop customized, cost-effective experimental equipment for physiology laboratories. PMID:24043254

  18. Three-dimensional printing physiology laboratory technology.

    PubMed

    Sulkin, Matthew S; Widder, Emily; Shao, Connie; Holzem, Katherine M; Gloschat, Christopher; Gutbrod, Sarah R; Efimov, Igor R

    2013-12-01

    Since its inception in 19th-century Germany, the physiology laboratory has been a complex and expensive research enterprise involving experts in various fields of science and engineering. Physiology research has been critically dependent on cutting-edge technological support of mechanical, electrical, optical, and more recently computer engineers. Evolution of modern experimental equipment is constrained by lack of direct communication between the physiological community and industry producing this equipment. Fortunately, recent advances in open source technologies, including three-dimensional printing, open source hardware and software, present an exciting opportunity to bring the design and development of research instrumentation to the end user, i.e., life scientists. Here we provide an overview on how to develop customized, cost-effective experimental equipment for physiology laboratories.

  19. Multiscale modeling of three-dimensional genome

    NASA Astrophysics Data System (ADS)

    Zhang, Bin; Wolynes, Peter

    The genome, the blueprint of life, contains nearly all the information needed to build and maintain an entire organism. A comprehensive understanding of the genome is of paramount interest to human health and will advance progress in many areas, including life sciences, medicine, and biotechnology. The overarching goal of my research is to understand the structure-dynamics-function relationships of the human genome. In this talk, I will be presenting our efforts in moving towards that goal, with a particular emphasis on studying the three-dimensional organization, the structure of the genome with multi-scale approaches. Specifically, I will discuss the reconstruction of genome structures at both interphase and metaphase by making use of data from chromosome conformation capture experiments. Computationally modeling of chromatin fiber at atomistic level from first principles will also be presented as our effort for studying the genome structure from bottom up.

  20. Three-Dimensional Complex Variables

    NASA Technical Reports Server (NTRS)

    Martin, E. Dale

    1988-01-01

    Report presents new theory of analytic functions of three-dimensional complex variables. While three-dimensional system subject to more limitations and more difficult to use than the two-dimensional system, useful in analysis of three-dimensional fluid flows, electrostatic potentials, and other phenomena involving harmonic functions.

  1. Computation of three-dimensional turbulent boundary layers with heat transfer in a plane of symmetry using embedded wall-layer functions

    NASA Technical Reports Server (NTRS)

    Degani, A. T.; Walker, J. D. A.

    1990-01-01

    In the calculation of turbulent boundary layers, a large number of mesh points are required to adequately resolve the intense variation in the velocity and enthalpy in the near-wall region. A substantial reduction in computational effort may be realized by representing the velocity and enthalpy profiles in the wall layer by analytical embedded functions. The effectively inviscid flow in the outer part of the boundary layer may then be resolved by employing a relatively coarser mesh. To obtain complete profiles, the outer numerical solution is matched asymptotically to the inner wall-layer analytical solution. To date, this approach has been restricted to two-dimensional flows; in the present study, a method which may be utilized for turbulent boundary layers with heat transfer in a plane of symmetry is developed as a first step in the application of the embedded-function method to full three-dimensional flows. The present method uses only about half as many mesh points as that required in a conventional procedure, which calculates the flow all the way to the wall, but there is no degradation in accuracy of the computed results.

  2. Validation of a novel semi-automated method for three-dimensional surface rendering of condyles using cone beam computed tomography data.

    PubMed

    Xi, T; van Loon, B; Fudalej, P; Bergé, S; Swennen, G; Maal, T

    2013-08-01

    Morphological changes of the condyles are often observed following orthognathic surgery. In addition to clinical assessment, radiographic evaluation of the condyles is required to distinguish the physiological condylar remodelling from pathological condylar resorption. The low contrast resolution and distortion of greyscale values in cone beam computed tomography (CBCT) scans have impeded an accurate three-dimensional (3D) rendering of the condyles. The current study proposes a novel semi-automated method for 3D rendering of condyles using CBCT datasets, and provides a clinical validation of this method. Ten patients were scanned using a standard CBCT scanning protocol. After defining the volume of interest, a greyscale cut-off value was selected to allow an automatic reconstruction of the condylar outline. The condylar contour was further enhanced manually by two independent observers to correct for the under- and over-contoured voxels. Volumetric measurements and surface distance maps of the condyles were computed. The mean within-observer and between-observer differences in condylar volume were 8.62 mm(3) and 6.13 mm(3), respectively. The mean discrepancy between intra- and inter-observer distance maps of the condylar surface was 0.22 mm and 0.13 mm, respectively. This novel method provides a reproducible tool for the 3D rendering of condyles, allowing longitudinal follow-up and quantitative analysis of condylar changes following orthognathic surgery.

  3. Application of an Adaptive Polynomial Chaos Expansion on Computationally Expensive Three-Dimensional Cardiovascular Models for Uncertainty Quantification and Sensitivity Analysis.

    PubMed

    Quicken, Sjeng; Donders, Wouter P; van Disseldorp, Emiel M J; Gashi, Kujtim; Mees, Barend M E; van de Vosse, Frans N; Lopata, Richard G P; Delhaas, Tammo; Huberts, Wouter

    2016-12-01

    When applying models to patient-specific situations, the impact of model input uncertainty on the model output uncertainty has to be assessed. Proper uncertainty quantification (UQ) and sensitivity analysis (SA) techniques are indispensable for this purpose. An efficient approach for UQ and SA is the generalized polynomial chaos expansion (gPCE) method, where model response is expanded into a finite series of polynomials that depend on the model input (i.e., a meta-model). However, because of the intrinsic high computational cost of three-dimensional (3D) cardiovascular models, performing the number of model evaluations required for the gPCE is often computationally prohibitively expensive. Recently, Blatman and Sudret (2010, "An Adaptive Algorithm to Build Up Sparse Polynomial Chaos Expansions for Stochastic Finite Element Analysis," Probab. Eng. Mech., 25(2), pp. 183-197) introduced the adaptive sparse gPCE (agPCE) in the field of structural engineering. This approach reduces the computational cost with respect to the gPCE, by only including polynomials that significantly increase the meta-model's quality. In this study, we demonstrate the agPCE by applying it to a 3D abdominal aortic aneurysm (AAA) wall mechanics model and a 3D model of flow through an arteriovenous fistula (AVF). The agPCE method was indeed able to perform UQ and SA at a significantly lower computational cost than the gPCE, while still retaining accurate results. Cost reductions ranged between 70-80% and 50-90% for the AAA and AVF model, respectively.

  4. RAMONA-4B a computer code with three-dimensional neutron kinetics for BWR and SBWR system transient - models and correlations

    SciTech Connect

    Rohatgi, U.S.; Cheng, H.S.; Khan, H.J.; Mallen, A.N.; Neymotin, L.Y.

    1998-03-01

    This document describes the major modifications and improvements made to the modeling of the RAMONA-3B/MOD0 code since 1981, when the code description and assessment report was completed. The new version of the code is RAMONA-4B. RAMONA-4B is a systems transient code for application to different versions of Boiling Water Reactors (BWR) such as the current BWR, the Advanced Boiling Water Reactor (ABWR), and the Simplified Boiling Water Reactor (SBWR). This code uses a three-dimensional neutron kinetics model coupled with a multichannel, non-equilibrium, drift-flux, two-phase flow formulation of the thermal hydraulics of the reactor vessel. The code is designed to analyze a wide spectrum of BWR core and system transients and instability issues. Chapter 1 is an overview of the code`s capabilities and limitations; Chapter 2 discusses the neutron kinetics modeling and the implementation of reactivity edits. Chapter 3 is an overview of the heat conduction calculations. Chapter 4 presents modifications to the thermal-hydraulics model of the vessel, recirculation loop, steam separators, boron transport, and SBWR specific components. Chapter 5 describes modeling of the plant control and safety systems. Chapter 6 presents and modeling of Balance of Plant (BOP). Chapter 7 describes the mechanistic containment model in the code. The content of this report is complementary to the RAMONA-3B code description and assessment document. 53 refs., 81 figs., 13 tabs.

  5. Three-dimensional display technologies.

    PubMed

    Geng, Jason

    2013-01-01

    The physical world around us is three-dimensional (3D), yet traditional display devices can show only two-dimensional (2D) flat images that lack depth (i.e., the third dimension) information. This fundamental restriction greatly limits our ability to perceive and to understand the complexity of real-world objects. Nearly 50% of the capability of the human brain is devoted to processing visual information [Human Anatomy & Physiology (Pearson, 2012)]. Flat images and 2D displays do not harness the brain's power effectively. With rapid advances in the electronics, optics, laser, and photonics fields, true 3D display technologies are making their way into the marketplace. 3D movies, 3D TV, 3D mobile devices, and 3D games have increasingly demanded true 3D display with no eyeglasses (autostereoscopic). Therefore, it would be very beneficial to readers of this journal to have a systematic review of state-of-the-art 3D display technologies.

  6. Quasi-Cartesian Finite-Difference Computation of Seismic Wave Propagation for a Three-Dimensional Sub-global Earth Model

    NASA Astrophysics Data System (ADS)

    Takenaka, H.; Komatsu, M.; Toyokuni, G.; Nakamura, T.; Okamoto, T.

    2015-12-01

    A simple and efficient finite-difference scheme is developed to compute seismic wave propagation for a partial spherical shell model of a three-dimensionally (3-D) heterogeneous global earth structure. This new scheme solves the elastodynamic equations in the "quasi-Cartesian" coordinate system similar to a local Cartesian one, instead of the spherical coordinate system, with a staggered-grid finite-difference method in time domain (FDTD) which is one of the most popular numerical methods in seismic motion simulations for local to regional scale models. The proposed scheme may be useful for modeling seismic wave propagation in a very large region of sub-global scale beyond regional and less than global ones, where the effects of roundness of earth cannot be ignored. In "quasi-Cartesian" coordinates, x, y, and z are set to be locally in directions of latitude, longitude and depth, respectively. The stencil for each of the x-derivatives then depends on the depth coordinate at the evaluation point, while the stencil for each of the y-derivatives varies with both coordinates of the depth and latitude. In order to reduce lateral variations of the horizontal finite-difference stencils over the computational domain, we move the target area to a location around the equator of the computational spherical coordinate system using a way similar to the conversion from equatorial coordinates to ecliptic coordinates. The developed scheme can be easily implemented in 3-D Cartesian FDTD codes for local to regional scale modeling by changing a very small part of the codes. Our scheme may be able to open a window for multi-scale modeling of seismic wave propagation in scales from sub-global to local one.

  7. A three-dimensional quantitative analysis of restenosis parameters after balloon angioplasty: comparison between semi-automatic computer-assisted planimetry and stereology.

    PubMed

    Salu, Koen J; Knaapen, Michiel W M; Bosmans, Johan M; Vrints, Chris J; Bult, Hidde

    2002-01-01

    Semi-automatic computer-assisted planimetry is often used for the quantification of restenosis parameters after balloon angioplasty although it is a time-consuming method. Moreover, slicing the artery to enable analysis of two-dimensional (2-D) images leads to a loss of information since the vessel structure is three-dimensional (3-D). Cavalieri's principle uses systematic random sampling allowing 3-D quantification. This study compares the accuracy and efficiency of planimetry versus point-counting measurements on restenosis parameters after balloon angioplasty and investigates the use of Cavalieri's principle for 3-D volume quantification. Bland and Altman plots showed good agreement between planimetry and point counting for the 2-D and 3-D quantification of lumen, internal elastic lamina (IEL) and external elastic lamina (EEL), with a slightly smaller agreement for intima and media. Mean values and induced coefficients of variation were similar for both methods for all parameters. Point counting induced a 6% error in its 3-D quantification, which is negligible in view of the biological variation (>90%) among animals. However, point counting was 3 times faster compared to planimetry, improving its efficiency. This study shows that combining Cavalieri's principle with point counting is a precise and efficient method for the 3-D quantification of restenosis parameters after balloon angioplasty.

  8. The location of midfacial landmarks according to the method of establishing the midsagittal reference plane in three-dimensional computed tomography analysis of facial asymmetry

    PubMed Central

    Kim, Min Sun; Lee, Eun Joo; Song, In Ja; Lee, Jae-Seo; Kang, Byung-Cheol

    2015-01-01

    Purpose The purpose of this study was to evaluate the influence of methods of establishing the midsagittal reference plane (MRP) on the locations of midfacial landmarks in the three-dimensional computed tomography (CT) analysis of facial asymmetry. Materials and Methods A total of 24 patients (12 male and 12 female; mean age, 22.5 years; age range, 18.2-29.7 years) with facial asymmetry were included in this study. The MRP was established using two different methods on each patient's CT image. The x-coordinates of four midfacial landmarks (the menton, nasion, upper incisor, and lower incisor) were obtained by measuring the distance and direction of the landmarks from the MRP, and the two methods were compared statistically. The direction of deviation and the severity of asymmetry found using each method were also compared. Results The x-coordinates of the four anatomic landmarks all showed a statistically significant difference between the two methods of establishing the MRP. For the nasion and lower incisor, six patients (25.0%) showed a change in the direction of deviation. The severity of asymmetry also changed in 16 patients (66.7%). Conclusion The results of this study suggest that the locations of midfacial landmarks change significantly according to the method used to establish the MRP. PMID:26730370

  9. Three-dimensional imaging of the spine using the EOS system: is it reliable? A comparative study using computed tomography imaging.

    PubMed

    Al-Aubaidi, Zaid; Lebel, David; Oudjhane, Kamaldine; Zeller, Reinhard

    2013-09-01

    The aim of this study was to evaluate the precision of three-dimensional geometry compared with computed tomography (CT) images. This retrospective study included patients who had undergone both imaging of the spine using the EOS imaging system and CT scanning of the spine. The apical vertebral orientation was also measured using the EOS imaging system and by CT. Other measures such as the Cobb angle and apical vertebral rotation and translation were used as the control variables to evaluate the potential discrepancy between the standing position in EOS imaging and the supine position in CT scanning. The apical vertebral orientations were 8.7° for the first measurement and 8.4° for the second measurement made by the first author, and 10.3° for the measurement made by the second author. The average of these measurements was 9.3° compared with 6.6° (P=0.65) obtained on CT scanning. The precision of EOS-based measurements of vertebral rotation has never been tested in clinical practice. Although it has limitations, this study suggests that the results obtained using EOS are comparable to those obtained on CT.

  10. Influence of scanning and reconstruction parameters on quality of three-dimensional surface models of the dental arches from cone beam computed tomography

    PubMed Central

    Couto Souza, Paulo; Jacobs, Reinhilde; de Azambuja Berti, Soraya; van der Stelt, Paul

    2009-01-01

    The study aim is to investigate the influence of scan field, mouth opening, voxel size, and segmentation threshold selections on the quality of the three-dimensional (3D) surface models of the dental arches from cone beam computed tomography (CBCT). 3D models of 25 patients scanned with one image intensifier CBCT system (NewTom 3G, QR SLR, Verona, Italy) using three field sizes in open- and closed-mouth positions were created at different voxel size resolutions. Two observers assessed the quality of the models independently on a five-point scale using specified criteria. The results indicate that large-field selection reduced the visibility of the teeth and the interproximal space. Also, large voxel size reduced the visibility of the occlusal surfaces and bone in the anterior region in both maxilla and mandible. Segmentation threshold was more variable in the maxilla than in the mandible. Closed-mouth scan complicated separating the jaws and reduced teeth surfaces visibility. The preliminary results from this image-intensifier system indicate that the use of medium or small scan fields in an open-mouth position with a small voxel is recommended to optimize quality of the 3D surface model reconstructions of the dental arches from CBCT. More research is needed to validate the results with other flat-panel detector-based CBCT systems. PMID:19506922

  11. RAMONA-4B a computer code with three-dimensional neutron kinetics for BWR and SBWR system transient - user`s manual

    SciTech Connect

    Rohatgi, U.S.; Cheng, H.S.; Khan, H.J.; Mallen, A.N.; Neymotin, L.Y.

    1998-03-01

    This document is the User`s Manual for the Boiling Water Reactor (BWR), and Simplified Boiling Water Reactor (SBWR) systems transient code RAMONA-4B. The code uses a three-dimensional neutron-kinetics model coupled with a multichannel, nonequilibrium, drift-flux, phase-flow model of the thermal hydraulics of the reactor vessel. The code is designed to analyze a wide spectrum of BWR core and system transients. Chapter 1 gives an overview of the code`s capabilities and limitations; Chapter 2 describes the code`s structure, lists major subroutines, and discusses the computer requirements. Chapter 3 is on code, auxillary codes, and instructions for running RAMONA-4B on Sun SPARC and IBM Workstations. Chapter 4 contains component descriptions and detailed card-by-card input instructions. Chapter 5 provides samples of the tabulated output for the steady-state and transient calculations and discusses the plotting procedures for the steady-state and transient calculations. Three appendices contain important user and programmer information: lists of plot variables (Appendix A) listings of input deck for sample problem (Appendix B), and a description of the plotting program PAD (Appendix C). 24 refs., 18 figs., 11 tabs.

  12. Three-dimensional visualization of the microvasculature of bile duct ligation-induced liver fibrosis in rats by x-ray phase-contrast imaging computed tomography

    NASA Astrophysics Data System (ADS)

    Xuan, Ruijiao; Zhao, Xinyan; Hu, Doudou; Jian, Jianbo; Wang, Tailing; Hu, Chunhong

    2015-07-01

    X-ray phase-contrast imaging (PCI) can substantially enhance contrast, and is particularly useful in differentiating biological soft tissues with small density differences. Combined with computed tomography (CT), PCI-CT enables the acquisition of accurate microstructures inside biological samples. In this study, liver microvasculature was visualized without contrast agents in vitro with PCI-CT using liver fibrosis samples induced by bile duct ligation (BDL) in rats. The histological section examination confirmed the correspondence of CT images with the microvascular morphology of the samples. By means of the PCI-CT and three-dimensional (3D) visualization technique, 3D microvascular structures in samples from different stages of liver fibrosis were clearly revealed. Different types of blood vessels, including portal veins and hepatic veins, in addition to ductular proliferation and bile ducts, could be distinguished with good sensitivity, excellent specificity and excellent accuracy. The study showed that PCI-CT could assess the morphological changes in liver microvasculature that result from fibrosis and allow characterization of the anatomical and pathological features of the microvasculature. With further development of PCI-CT technique, it may become a novel noninvasive imaging technique for the auxiliary analysis of liver fibrosis.

  13. Computation of dynamic seismic responses to viscous fluid of digitized three-dimensional Berea sandstones with a coupled finite-difference method.

    PubMed

    Zhang, Yang; Toksöz, M Nafi

    2012-08-01

    The seismic response of saturated porous rocks is studied numerically using microtomographic images of three-dimensional digitized Berea sandstones. A stress-strain calculation is employed to compute the velocities and attenuations of rock samples whose sizes are much smaller than the seismic wavelength of interest. To compensate for the contributions of small cracks lost in the imaging process to the total velocity and attenuation, a hybrid method is developed to recover the crack distribution, in which the differential effective medium theory, the Kuster-Toksöz model, and a modified squirt-flow model are utilized in a two-step Monte Carlo inversion. In the inversion, the velocities of P- and S-waves measured for the dry and water-saturated cases, and the measured attenuation of P-waves for different fluids are used. By using such a hybrid method, both the velocities of saturated porous rocks and the attenuations are predicted accurately when compared to laboratory data. The hybrid method is a practical way to model numerically the seismic properties of saturated porous rocks until very high resolution digital data are available. Cracks lost in the imaging process are critical for accurately predicting velocities and attenuations of saturated porous rocks.

  14. Volumetric stability of autogenous bone graft with mandibular body bone: cone-beam computed tomography and three-dimensional reconstruction analysis

    PubMed Central

    Lee, Hyeong-Geun

    2015-01-01

    Objectives The purpose of this study was to estimate the volumetric change of augmented autobone harvested from mandibular body cortical bone, using cone-beam computed tomography (CBCT) and three-dimensional reconstruction. In addition, the clinical success of dental implants placed 4 to 6 months after bone grafting was also evaluated. Materials and Methods Ninety-five patients (48 men and 47 women) aged 19 to 72 years were included in this study. A total of 128 graft sites were evaluated. The graft sites were divided into three parts: anterior and both posterior regions of one jaw. All patients included in the study were scheduled for an onlay graft and implantation using a two-stage procedure. The dental implants were inserted 4 to 6 months after the bone graft. Volumetric stability was evaluated by serial CBCT images. Results No major complications were observed for the donor sites. A total of 128 block bones were used to augment severely resorbed alveolar bone. Only 1 of the 128 bone grafts was resorbed by more than half, and that was due to infection. In total, the average amount of residual grafted bone after resorption at the recipient sites was 74.6%±8.4%. Conclusion Volumetric stability of mandibular body autogenous block grafts is predictable. The procedure is satisfactory for patients who want dental implants regardless of atrophic alveolar bone. PMID:26568924

  15. Predetermination of root canal lengths in molar teeth: A comparison between radiovisiography and two-dimensional and three-dimensional measurements using cone-beam computed tomography

    PubMed Central

    Dhingra, Annil; Dayal, Charu; Singh, Amteshwar; Bhardwaj, Neetika

    2015-01-01

    Introduction: Obtaining a correct working length is critical to the success of endodontic therapy. The aim of this clinical study was to compare the effect of working length determination using radiovisiography (RVG) and two-dimensional (2D) and three-dimensional (3D) measurements using cone-beam computed tomography (CBCT). Materials and Methods: Thirty mandibular teeth were taken and three groups of 10 each were made. Teeth with previous endodontic treatments, metal restorations, resorptions, incomplete apex formations, and multiple visible foramina were excluded. The root canal length was determined using RVG, CBCT measurement method 2D, and CBCT measurement method 3D. The difference between CBCT measurements, RVG, and the actual canal length were compared to evaluate the accuracy of each method. Results: No significant statistically difference was seen with 3D measurements and actual measurements. Measurements with RVG were better than CBCT 2D. Conclusion: Under experimental conditions, CBCT 3D measurements are accurate than RVG and CBCT 2D in the determination of root canal length. PMID:26752880

  16. Use of cone-beam computed tomography and three-dimensional modeling for assessment of anomalous pulp canal configuration: a case report.

    PubMed

    Sinanoglu, Alper; Helvacioglu-Yigit, Dilek; Mutlu, Ibrahim

    2015-05-01

    Three-dimensional (3D) reconstruction of cone-beam computed tomography (CBCT) scans appears to be a valuable method for assessing pulp canal configuration. The aim of this report is to describe endodontic treatment of a mandibular second premolar with aberrant pulp canal morphology detected by CBCT and confirmed by 3D modeling. An accessory canal was suspected during endodontic treatment of the mandibular left second premolar in a 21 year old woman with a chief complaint of pulsating pain. Axial cross-sectional CBCT scans revealed that the pulp canal divided into mesiobuccal, lingual, and buccal canals in the middle third and ended as four separate foramina. 3D modeling confirmed the anomalous configuration of the fused root with a deep lingual groove. Endodontic treatment of the tooth was completed in two appointments. The root canals were obturated using lateral compaction of gutta-percha and root canal sealer. The tooth remained asymptomatic and did not develop periapical pathology until 12 months postoperatively. CBCT and 3D modeling enable preoperative evaluation of aberrant root canal systems and facilitate endodontic treatment.

  17. An experimental and three-dimensional computational study on the aerodynamic contribution to the passive pitching motion of flapping wings in hovering flies.

    PubMed

    Ishihara, D; Horie, T; Niho, T

    2014-11-07

    The relative importance of the wing's inertial and aerodynamic forces is the key to revealing how the kinematical characteristics of the passive pitching motion of insect flapping wings are generated, which is still unclear irrespective of its importance in the design of insect-like micro air vehicles. Therefore, we investigate three species of flies in order to reveal this, using a novel fluid-structure interaction analysis that consists of a dynamically scaled experiment and a three-dimensional finite element analysis. In the experiment, the dynamic similarity between the lumped torsional flexibility model as a first approximation of the dipteran wing and the actual insect is measured by the Reynolds number Re, the Strouhal number St, the mass ratio M, and the Cauchy number Ch. In the computation, the three-dimension is important in order to simulate the stable leading edge vortex and lift force in the present Re regime over 254. The drawback of the present experiment is the difficulty in satisfying the condition of M due to the limitation of available solid materials. The novelty of the present analysis is to complement this drawback using the computation. We analyze the following two cases: (a) The equilibrium between the wing's elastic and fluid forces is dynamically similar to that of the actual insect, while the wing's inertial force can be ignored. (b) All forces are dynamically similar to those of the actual insect. From the comparison between the results of cases (a) and (b), we evaluate the contributions of the equilibrium between the aerodynamic and the wing's elastic forces and the wing's inertial force to the passive pitching motion as 80-90% and 10-20%, respectively. It follows from these results that the dipteran passive pitching motion will be based on the equilibrium between the wing's elastic and aerodynamic forces, while it will be enhanced by the wing's inertial force.

  18. Three dimensional Dirac semimetals

    NASA Astrophysics Data System (ADS)

    Zaheer, Saad

    We extend the physics of graphene to three dimensional systems by showing that Dirac points can exist on the Fermi surface of realistic materials in three dimensions. Many of the exotic electronic properties of graphene can be ascribed to the pseudorelativistic behavior of its charge carriers due to two dimensional Dirac points on the Fermi surface. We show that certain nonsymmorphic spacegroups exhibit Dirac points among the irreducible representations of the appropriate little group at high symmetry points on the surface of the Brillouin zone. We provide a list of all Brillouin zone momenta in the 230 spacegroups that can host Dirac points. We describe microscopic considerations necessary to design materials in one of the candidate spacegroups such that the Dirac point appears at the Fermi energy without any additional non-Dirac-like Fermi pockets. We use density functional theory based methods to propose six new Dirac semimetals: BiO 2 and SbO2 in the beta-cristobalite lattice (spacegroup 227), and BiCaSiO4, BiMgSiO4, BiAlInO 4, and BiZnSiO4 in the distorted spinels lattice (spacegroup 74). Additionally we derive effective Dirac Hamiltonians given group representative operators as well as tight binding models incorporating spin-orbit coupling. Finally we study the Fermi surface of zincblende (spacegroup 216) HgTe which is effectively point-like at Gamma in the Brillouin zone and exhibits accidental degeneracies along a threefold rotation axis. Whereas compressive strain gaps the band structure into a topological insulator, tensile strain shifts the accidental degeneracies away from Gamma and enlarges the Fermi surface. States on the Fermi surface exhibit nontrivial spin texture marked by winding of spins around the threefold rotation axis and by spin vortices indicating a change in the winding number. This is confirmed by microscopic calculations performed in tensile strained HgTe and Hg0.5Zn 0.5 Te as well as k.p theory. We conclude with a summary of recent

  19. Distribution of lithostratigraphic units within the central block of Yucca Mountain, Nevada: A three-dimensional computer-based model, Version YMP.R2.0

    SciTech Connect

    Buesch, D.C.; Nelson, J.E.; Dickerson, R.P.; Drake, R.M. II; San Juan, C.A.; Spengler, R.W.; Geslin, J.K.; Moyer, T.C.

    1996-09-01

    Yucca Mountain, Nevada is underlain by 14.0 to 11.6 Ma volcanic rocks tilted eastward 3{degree} to 20{degree} and cut by faults that were primarily active between 12.7 and 11.6 Ma. A three-dimensional computer-based model of the central block of the mountain consists of seven structural subblocks composed of six formations and the interstratified-bedded tuffaceous deposits. Rocks from the 12.7 Ma Tiva Canyon Tuff, which forms most of the exposed rocks on the mountain, to the 13.1 Ma Prow Pass Tuff are modeled with 13 surfaces. Modeled units represent single formations such as the Pah Canyon Tuff, grouped units such as the combination of the Yucca Mountain Tuff with the superjacent bedded tuff, and divisions of the Topopah Spring Tuff such as the crystal-poor vitrophyre interval. The model is based on data from 75 boreholes from which a structure contour map at the base of the Tiva Canyon Tuff and isochore maps for each unit are constructed to serve as primary input. Modeling consists of an iterative cycle that begins with the primary structure-contour map from which isochore values of the subjacent model unit are subtracted to produce the structure contour map on the base of the unit. This new structure contour map forms the input for another cycle of isochore subtraction to produce the next structure contour map. In this method of solids modeling, the model units are presented by surfaces (structure contour maps), and all surfaces are stored in the model. Surfaces can be converted to form volumes of model units with additional effort. This lithostratigraphic and structural model can be used for (1) storing data from, and planning future, site characterization activities, (2) preliminary geometry of units for design of Exploratory Studies Facility and potential repository, and (3) performance assessment evaluations.

  20. Mathematical modelling and computational study of two-dimensional and three-dimensional dynamics of receptor-ligand interactions in signalling response mechanisms.

    PubMed

    García-Peñarrubia, Pilar; Gálvez, Juan J; Gálvez, Jesús

    2014-09-01

    Cell signalling processes involve receptor trafficking through highly connected networks of interacting components. The binding of surface receptors to their specific ligands is a key factor for the control and triggering of signalling pathways. But the binding process still presents many enigmas and, by analogy with surface catalytic reactions, two different mechanisms can be conceived: the first mechanism is related to the Eley-Rideal (ER) mechanism, i.e. the bulk-dissolved ligand interacts directly by pure three-dimensional (3D) diffusion with the specific surface receptor; the second mechanism is similar to the Langmuir-Hinshelwood (LH) process, i.e. 3D diffusion of the ligand to the cell surface followed by reversible ligand adsorption and subsequent two-dimensional (2D) surface diffusion to the receptor. A situation where both mechanisms simultaneously contribute to the signalling process could also occur. The aim of this paper is to perform a computational study of the behavior of the signalling response when these different mechanisms for ligand-receptor interactions are integrated into a model for signal transduction and ligand transport. To this end, partial differential equations have been used to develop spatio-temporal models that show trafficking dynamics of ligands, cell surface components, and intracellular signalling molecules through the different domains of the system. The mathematical modeling developed for these mechanisms has been applied to the study of two situations frequently found in cell systems: (a) dependence of the signal response on cell density; and (b) enhancement of the signalling response in a synaptic environment.

  1. Diversity and Determinants of the Three-dimensional Anatomical Axis of the Heart as Revealed Using Multidetector-row Computed Tomography.

    PubMed

    Mori, Shumpei; Anderson, Robert H; Tahara, Natsuko; Izawa, Yu; Toba, Takayoshi; Fujiwara, Sei; Shimoyama, Shinsuke; Watanabe, Yoshiaki; Nishii, Tatsuya; Kono, Atsushi K; Hirata, Ken-Ichi

    2017-02-08

    The location of the heart within the thorax varies significantly between individuals. The resultant diversity of the anatomical cardiac long axis, however, and its determinants, have yet to be systematically investigated. We enrolled 100 consecutive patients undergoing coronary arterial computed tomographic angiography, decomposing the vector of the anatomical cardiac long axis by projecting it to horizontal, frontal, and sagittal planes. The projected vectors on each plane were then converted into three rotation angles using coordinate transformation. We then measured the extent of aortic wedging, using the vertical distance between the inferior margins of the non-adjacent aortic sinus and the epicardium. We took the aortic root rotation angle to be zero when an "en face" view of the right coronary aortic sinus was obtained in the frontal view, defining leftward rotation to be positive. The mean horizontal, frontal, and sagittal rotation angles were 48.7° ± 9.5°, 52.3° ± 12.0°, and 34.0° ± 11.2°, respectively. The mean extent of aortic wedging, and the aortic root rotation angle, were 42.7 ± 9.8 mm, and 5.3° ± 16.4°. Horizontal rotation of the anatomical axis was associated with leftward and ventral rotation, and vice versa. Multivariate analysis showed aortic root rotation to be associated with horizontal cardiac rotation, while aortic wedging is associated with frontal and sagittal cardiac rotation. We have quantified the marked individual variation observed in the anatomical axis of the living heart, identifying the different mechanisms involved in producing the marked three-dimensional diversity of the living heart. Anat Rec, 2017. © 2017 Wiley Periodicals, Inc.

  2. Using semi-automated segmentation of computed tomography datasets for three-dimensional visualization and volume measurements of equine paranasal sinuses.

    PubMed

    Brinkschulte, Markus; Bienert-Zeit, Astrid; Lüpke, Matthias; Hellige, Maren; Staszyk, Carsten; Ohnesorge, Bernhard

    2013-01-01

    The system of the paranasal sinuses morphologically represents one of the most complex parts of the equine body. A clear understanding of spatial relationships is needed for correct diagnosis and treatment. The purpose of this study was to describe the anatomy and volume of equine paranasal sinuses using three-dimensional (3D) reformatted renderings of computed tomography (CT) slices. Heads of 18 cadaver horses, aged 2-25 years, were analyzed by the use of separate semi-automated segmentation of the following bilateral paranasal sinus compartments: rostral maxillary sinus (Sinus maxillaris rostralis), ventral conchal sinus (Sinus conchae ventralis), caudal maxillary sinus (Sinus maxillaris caudalis), dorsal conchal sinus (Sinus conchae dorsalis), frontal sinus (Sinus frontalis), sphenopalatine sinus (Sinus sphenopalatinus), and middle conchal sinus (Sinus conchae mediae). Reconstructed structures were displayed separately, grouped, or altogether as transparent or solid elements to visualize individual paranasal sinus morphology. The paranasal sinuses appeared to be divided into two systems by the maxillary septum (Septum sinuum maxillarium). The first or rostral system included the rostral maxillary and ventral conchal sinus. The second or caudal system included the caudal maxillary, dorsal conchal, frontal, sphenopalatine, and middle conchal sinuses. These two systems overlapped and were interlocked due to the oblique orientation of the maxillary septum. Total volumes of the paranasal sinuses ranged from 911.50 to 1502.00 ml (mean ± SD, 1151.00 ± 186.30 ml). 3D renderings of equine paranasal sinuses by use of semi-automated segmentation of CT-datasets improved understanding of this anatomically challenging region.

  3. Three-dimensional micro computed tomography analysis of the lung vasculature and differential adipose proteomics in the Sugen/hypoxia rat model of pulmonary arterial hypertension

    PubMed Central

    Verdelis, Kostas; Passineau, Michael J.; Faight, Erin M.; Zourelias, Lee; Wu, Changgong; Chong, Rong; Benza, Raymond L.

    2016-01-01

    Abstract Pulmonary arterial hypertension (PAH) is a rare disease characterized by significant vascular remodeling. The obesity epidemic has produced great interest in the relationship between small visceral adipose tissue depots producing localized inflammatory conditions, which may link metabolism, innate immunity, and vascular remodeling. This study used novel micro computed tomography (microCT) three-dimensional modeling to investigate the degree of remodeling of the lung vasculature and differential proteomics to determine small visceral adipose dysfunction in rats with severe PAH. Sprague-Dawley rats were subjected to a subcutaneous injection of vascular endothelial growth factor receptor blocker (Sugen 5416) with subsequent hypoxia exposure for 3 weeks (SU/hyp). At 12 weeks after hypoxia, microCT analysis showed a decrease in the ratio of vascular to total tissue volume within the SU/hyp group (mean ± standard deviation: 0.27 ± 0.066; P = 0.02) with increased vascular separation (0.37 ± 0.062 mm; P = 0.02) when compared with the control (0.34 ± 0.084 and 0.30 ± 0.072 mm). Differential proteomics detected an up-regulation of complement protein 3 (C3; SU/hyp∶control ratio = 2.86) and the adipose tissue–specific fatty acid binding protein-4 (FABP4, 2.66) in the heart adipose of the SU/hyp. Significant remodeling of the lung vasculature validates the efficacy of the SU/hyp rat for modeling human PAH. The upregulation of C3 and FABP4 within the heart adipose implicates small visceral adipose dysfunction. C3 has been associated with vascular stiffness, and FABP4 suppresses peroxisome proliferator–activated receptor, which is a major regulator of adipose function and known to be downregulated in PAH. These findings reveal that small visceral adipose tissue within the SU/hyp model provides mechanistic links for vascular remodeling and adipose dysfunction in the pathophysiology of PAH. PMID:28090302

  4. Imaging the Aqueous Humor Outflow Pathway in Human Eyes by Three-dimensional Micro-computed Tomography (3D micro-CT)

    SciTech Connect

    C Hann; M Bentley; A Vercnocke; E Ritman; M Fautsch

    2011-12-31

    The site of outflow resistance leading to elevated intraocular pressure in primary open-angle glaucoma is believed to be located in the region of Schlemm's canal inner wall endothelium, its basement membrane and the adjacent juxtacanalicular tissue. Evidence also suggests collector channels and intrascleral vessels may have a role in intraocular pressure in both normal and glaucoma eyes. Traditional imaging modalities limit the ability to view both proximal and distal portions of the trabecular outflow pathway as a single unit. In this study, we examined the effectiveness of three-dimensional micro-computed tomography (3D micro-CT) as a potential method to view the trabecular outflow pathway. Two normal human eyes were used: one immersion fixed in 4% paraformaldehyde and one with anterior chamber perfusion at 10 mmHg followed by perfusion fixation in 4% paraformaldehyde/2% glutaraldehyde. Both eyes were postfixed in 1% osmium tetroxide and scanned with 3D micro-CT at 2 {mu}m or 5 {mu}m voxel resolution. In the immersion fixed eye, 24 collector channels were identified with an average orifice size of 27.5 {+-} 5 {mu}m. In comparison, the perfusion fixed eye had 29 collector channels with a mean orifice size of 40.5 {+-} 13 {mu}m. Collector channels were not evenly dispersed around the circumference of the eye. There was no significant difference in the length of Schlemm's canal in the immersed versus the perfused eye (33.2 versus 35.1 mm). Structures, locations and size measurements identified by 3D micro-CT were confirmed by correlative light microscopy. These findings confirm 3D micro-CT can be used effectively for the non-invasive examination of the trabecular meshwork, Schlemm's canal, collector channels and intrascleral vasculature that comprise the distal outflow pathway. This imaging modality will be useful for non-invasive study of the role of the trabecular outflow pathway as a whole unit.

  5. Micro-computed tomography-based three-dimensional kinematic analysis during lateral bending for spinal fusion assessment in a rat posterolateral lumbar fusion model.

    PubMed

    Yamaguchi, Tomonori; Inoue, Nozomu; Sah, Robert L; Lee, Yu-Po; Taborek, Alexander P; Williams, Gregory M; Moseley, Timothy A; Bae, Won C; Masuda, Koichi

    2014-07-01

    Rat posterolateral lumbar fusion (PLF) models have been used to assess the safety and effectiveness of new bone substitutes and osteoinductive growth factors using palpation, radiography, micro-computed tomography (μCT), and histology as standard methods to evaluate spinal fusion. Despite increased numbers of PLF studies involving alternative bone substitutes and growth factors, the quantitative assessment of treatment efficacy during spinal motion has been limited. The purpose of this study was to evaluate the effect of spinal fusion on lumbar spine segment stability during lateral bending using a μCT-based three-dimensional (3D) kinematic analysis in the rat PLF model. Fourteen athymic male rats underwent PLF surgery at L4/5 and received bone grafts harvested from the ilium and femurs of syngeneic rats (Isograft, n=7) or no graft (Sham, n=7). At 8 weeks after the PLF surgery, spinal fusion was assessed by manual palpation, plain radiography, μCT, and histology. To determine lumbar segmental motions at the operated level during lateral bending, 3D kinematic analysis was performed. The Isograft group, but not the Sham group, showed spinal fusion on manual palpation (6/7), solid fusion mass in radiographs (6/7), as well as bone bridging in μCT and histological images (5/7). Compared to the Sham group, the Isograft group revealed limited 3D lateral bending angular range of motion and lateral translation during lateral bending at the fused segment where disc height narrowing was observed. This μCT-based 3D kinematic analysis can provide a quantitative assessment of spinal fusion in a rat PLF model to complement current gold standard methods used for efficacy assessment of new therapeutic approaches.

  6. PORTA: A three-dimensional multilevel radiative transfer code for modeling the intensity and polarization of spectral lines with massively parallel computers

    NASA Astrophysics Data System (ADS)

    Štěpán, Jiří; Trujillo Bueno, Javier

    2013-09-01

    The interpretation of the intensity and polarization of the spectral line radiation produced in the atmosphere of the Sun and of other stars requires solving a radiative transfer problem that can be very complex, especially when the main interest lies in modeling the spectral line polarization produced by scattering processes and the Hanle and Zeeman effects. One of the difficulties is that the plasma of a stellar atmosphere can be highly inhomogeneous and dynamic, which implies the need to solve the non-equilibrium problem of the generation and transfer of polarized radiation in realistic three-dimensional (3D) stellar atmospheric models. Here we present PORTA, an efficient multilevel radiative transfer code we have developed for the simulation of the spectral line polarization caused by scattering processes and the Hanle and Zeeman effects in 3D models of stellar atmospheres. The numerical method of solution is based on the non-linear multigrid iterative method and on a novel short-characteristics formal solver of the Stokes-vector transfer equation which uses monotonic Bézier interpolation. Therefore, with PORTA the computing time needed to obtain at each spatial grid point the self-consistent values of the atomic density matrix (which quantifies the excitation state of the atomic system) scales linearly with the total number of grid points. Another crucial feature of PORTA is its parallelization strategy, which allows us to speed up the numerical solution of complicated 3D problems by several orders of magnitude with respect to sequential radiative transfer approaches, given its excellent linear scaling with the number of available processors. The PORTA code can also be conveniently applied to solve the simpler 3D radiative transfer problem of unpolarized radiation in multilevel systems.

  7. Analysis of the size variability of the human normal and cleft palate fetal nasal capsule by means of three-dimensional computer reconstruction of histologic preparations.

    PubMed

    Siegel, M I; Mooney, M P; Kimes, K R; Todhunter, J

    1987-07-01

    As part of an ongoing study of cleft palate fetal morphology, normal and dysmorphic development of the human fetal nasal capsule was studied in a cross-sectional sample of 29 human fetuses (20 "normal" and 9 cleft), ranging in age from 8 to 21 postmenstrual weeks. The specimens were celloidin embedded, sectioned at 20 microns, and every tenth section stained with hematoxylin and eosin. A computer reconstruction technique was applied to produce three-dimensional representations of the nasal capsule, nasal septal cartilage, and nasal airway. Qualitatively, the cleft palate nasal capsule exhibited gross abnormalities including cartilaginous nasal septum deformities, abnormal septal volume and hypertrophy, reduced nasal airway and capsule volumes, and abnormal spatial relationships between the nasal capsule components. These results suggest that the reduced nasal airways, noted clinically in cleft perinates, may be a function of an interaction of nasal capsule deficiency and nasal septum hypertrophy. However, when lengths and volumes were plotted against fetal postmenstrual age, producing fetal "growth" curves, no significant differences (p greater than 0.05) were noted for growth rates (slopes) or nasal capsule size between the normal and cleft palate fetal samples. Curvilinear regression analysis revealed that both normal and cleft palate nasal capsule and septum lengths changed in a sigmoidal fashion, with the steepest increases from 13 to 17 weeks. In contrast, nasal capsule, airway, and septum volumes changed curvilinearly, showing slow relative growth rates from 8 to 17 weeks, which increased sharply from 18 to 21 weeks. Results suggest that from 8 to 21 weeks prenatally, normal and cleft palate specimens exhibited a similar pattern of fetal nasal capsule development that was characterized by an initial anteroposterior elongation followed by circumferential (i.e., volumetric) growth.

  8. Accuracy of three-dimensional measurements obtained from cone beam computed tomography surface-rendered images for cephalometric analysis: influence of patient scanning position.

    PubMed

    Hassan, Bassam; van der Stelt, Paul; Sanderink, Gerard

    2009-04-01

    The aims of this study were to assess the accuracy of linear measurements on three-dimensional (3D) surface-rendered images generated from cone beam computed tomography (CBCT) in comparison with two-dimensional (2D) slices and 2D lateral and postero-anterior (PA) cephalometric projections, and to investigate the influence of patient head position in the scanner on measurement accuracy. Eight dry human skulls were scanned twice using NewTom 3G CBCT in an ideal and a rotated position and the resulting datasets were used to create 3D surface-rendered images, 2D tomographic slices, and 2D lateral and PA projections. Ten linear distances were defined for cephalometric measurements. The physical and radiographic measurements were repeated twice by three independent observers and were compared using repeated measures analysis of variance (P=0.05). The radiographic measurements were also compared between the ideal and the rotated scan positions. The radiographic measurements of the 3D images were closer to the physical measurements than the 2D slices and 2D projection images. No statistically significant difference was found between the ideal and the rotated scan measurements for the 3D images and the 2D tomographic slices. A statistically significant difference (P<0.001) was observed between the ideal and rotated scan positions for the 2D projection images. The findings indicate that measurements based on 3D CBCT surface images are accurate and that small variations in the patient's head position do not influence measurement accuracy.

  9. Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation

    PubMed Central

    2012-01-01

    Background There is overwhelming evidence that in vitro three-dimensional tumor cell cultures more accurately reflect the complex in vivo microenvironment than simple two-dimensional cell monolayers, not least with respect to gene expression profiles, signaling pathway activity and drug sensitivity. However, most currently available three-dimensional techniques are time consuming and/or lack reproducibility; thus standardized and rapid protocols are urgently needed. Results To address this requirement, we have developed a versatile toolkit of reproducible three-dimensional tumor spheroid models for dynamic, automated, quantitative imaging and analysis that are compatible with routine high-throughput preclinical studies. Not only do these microplate methods measure three-dimensional tumor growth, but they have also been significantly enhanced to facilitate a range of functional assays exemplifying additional key hallmarks of cancer, namely cell motility and matrix invasion. Moreover, mutual tissue invasion and angiogenesis is accommodated by coculturing tumor spheroids with murine embryoid bodies within which angiogenic differentiation occurs. Highly malignant human tumor cells were selected to exemplify therapeutic effects of three specific molecularly-targeted agents: PI-103 (phosphatidylinositol-3-kinase (PI3K)-mammalian target of rapamycin (mTOR) inhibitor), 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) (heat shock protein 90 (HSP90) inhibitor) and CCT130234 (in-house phospholipase C (PLC)γ inhibitor). Fully automated analysis using a Celigo cytometer was validated for tumor spheroid growth and invasion against standard image analysis techniques, with excellent reproducibility and significantly increased throughput. In addition, we discovered key differential sensitivities to targeted agents between two-dimensional and three-dimensional cultures, and also demonstrated enhanced potency of some agents against cell migration/invasion compared with

  10. GRID2D/3D: A computer program for generating grid systems in complex-shaped two- and three-dimensional spatial domains. Part 1: Theory and method

    NASA Technical Reports Server (NTRS)

    Shih, T. I.-P.; Bailey, R. T.; Nguyen, H. L.; Roelke, R. J.

    1990-01-01

    An efficient computer program, called GRID2D/3D was developed to generate single and composite grid systems within geometrically complex two- and three-dimensional (2- and 3-D) spatial domains that can deform with time. GRID2D/3D generates single grid systems by using algebraic grid generation methods based on transfinite interpolation in which the distribution of grid points within the spatial domain is controlled by stretching functions. All single grid systems generated by GRID2D/3D can have grid lines that are continuous and differentiable everywhere up to the second-order. Also, grid lines can intersect boundaries of the spatial domain orthogonally. GRID2D/3D generates composite grid systems by patching together two or more single grid systems. The patching can be discontinuous or continuous. For continuous composite grid systems, the grid lines are continuous and differentiable everywhere up to the second-order except at interfaces where different single grid systems meet. At interfaces where different single grid systems meet, the grid lines are only differentiable up to the first-order. For 2-D spatial domains, the boundary curves are described by using either cubic or tension spline interpolation. For 3-D spatial domains, the boundary surfaces are described by using either linear Coon's interpolation, bi-hyperbolic spline interpolation, or a new technique referred to as 3-D bi-directional Hermite interpolation. Since grid systems generated by algebraic methods can have grid lines that overlap one another, GRID2D/3D contains a graphics package for evaluating the grid systems generated. With the graphics package, the user can generate grid systems in an interactive manner with the grid generation part of GRID2D/3D. GRID2D/3D is written in FORTRAN 77 and can be run on any IBM PC, XT, or AT compatible computer. In order to use GRID2D/3D on workstations or mainframe computers, some minor modifications must be made in the graphics part of the program; no

  11. Advances and challenges in computational plasma science

    NASA Astrophysics Data System (ADS)

    Tang, W. M.

    2005-02-01

    Scientific simulation, which provides a natural bridge between theory and experiment, is an essential tool for understanding complex plasma behaviour. Recent advances in simulations of magnetically confined plasmas are reviewed in this paper, with illustrative examples, chosen from associated research areas such as microturbulence, magnetohydrodynamics and other topics. Progress has been stimulated, in particular, by the exponential growth of computer speed along with significant improvements in computer technology. The advances in both particle and fluid simulations of fine-scale turbulence and large-scale dynamics have produced increasingly good agreement between experimental observations and computational modelling. This was enabled by two key factors: (a) innovative advances in analytic and computational methods for developing reduced descriptions of physics phenomena spanning widely disparate temporal and spatial scales and (b) access to powerful new computational resources. Excellent progress has been made in developing codes for which computer run-time and problem-size scale well with the number of processors on massively parallel processors (MPPs). Examples include the effective usage of the full power of multi-teraflop (multi-trillion floating point computations per second) MPPs to produce three-dimensional, general geometry, nonlinear particle simulations that have accelerated advances in understanding the nature of turbulence self-regulation by zonal flows. These calculations, which typically utilized billions of particles for thousands of time-steps, would not have been possible without access to powerful present generation MPP computers and the associated diagnostic and visualization capabilities. In looking towards the future, the current results from advanced simulations provide great encouragement for being able to include increasingly realistic dynamics to enable deeper physics insights into plasmas in both natural and laboratory environments. This

  12. Three-dimensional echocardiographic technology.

    PubMed

    Salgo, Ivan S

    2007-05-01

    This article addresses the current state of the art of technology in three-dimensional echocardiography as it applies to transducer design, beam forming, display, and quantification. Because three-dimensional echocardiography encompasses many technical and clinical areas, this article reviews its strengths and limitations and concludes with an analysis of what to use when.

  13. Three-dimensional diffusion of non-sorbing species in porous sandstone: computer simulation based on X-ray microtomography using synchrotron radiation.

    PubMed

    Nakashima, Yoshito; Nakano, Tsukasa; Nakamura, Koichi; Uesugi, Kentaro; Tsuchiyama, Akira; Ikeda, Susumu

    2004-10-01

    The diffusion pathways of porous sandstone were examined by a three-dimensional (3-D) imaging technique based on X-ray computed tomography (CT) using the SPring-8 (Super Photon ring-8 GeV, Hyogo, Japan) synchrotron radiation facility. The analysis was undertaken to develop better understanding of the diffusion pathways in natural rock as a key factor in clarifying the detailed mechanism of the diffusion of radionuclides and water molecules through the pore spaces of natural barriers in underground nuclear waste disposal facilities. A cylindrical sample (diameter 4 mm, length 6 mm) of sandstone (porosity 0.14) was imaged to obtain a 3-D image set of 450(3) voxels=2.62(3) mm(3). Through cluster-labeling analysis of the 3-D image set, it was revealed that 89% of the pore space forms a single large pore-cluster responsible for macroscopic diffusive transport, while only 11% of the pore space is made up of isolated pores that are not involved in long-range diffusive transport. Computer simulations of the 3-D diffusion of non-sorbing random walkers in the largest pore cluster were performed to calculate the surface-to-volume ratio of the pore, tortuosity (diffusion coefficient in free space divided by that in porous rock). The results showed that (i) the simulated surface-to-volume ratio is about 60% of the results obtained by conventional pulsed-field-gradient proton nuclear magnetic resonance (NMR) laboratory experiments and (ii) the simulated tortuosity is five to seven times larger than the results of laboratory diffusion experiments using non-sorbing I(-) and Br(-). These discrepancies are probably attributed to the intrinsic sample heterogeneity and limited spatial resolution of the CT system. The permeability was also estimated based on the NMR diffusometry theory using the results of the random walk simulations via the Kozeny-Carman equation. The estimated permeability involved an error of about 20% compared with the permeability measured by the conventional

  14. FluorWPS: A Monte Carlo ray-tracing model to compute sun-induced chlorophyll fluorescence of three-dimensional canopy

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A model to simulate radiative transfer (RT) of sun-induced chlorophyll fluorescence (SIF) of three-dimensional (3-D) canopy, FluorWPS, was proposed and evaluated. The inclusion of fluorescence excitation was implemented with the ‘weight reduction’ and ‘photon spread’ concepts based on Monte Carlo ra...

  15. Management of a Two-rooted Maxillary Central Incisor Using Cone-beam Computed Tomography: Importance of Three-dimensional Imaging

    PubMed Central

    Kumar Gupta, Saurabh; Saxena, Payal; Khetarpal, Shaleen; Solanki, Mishthu

    2015-01-01

    We report a rare case of a two-rooted maxillary central incisor, stressing the importance of three-dimensional imaging in treatment planning and conservative approach of management. Endodontic treatment of this central incisor was carried out with a successful outcome. PMID:26697155

  16. Three-dimensional laser microvision.

    PubMed

    Shimotahira, H; Iizuka, K; Chu, S C; Wah, C; Costen, F; Yoshikuni, Y

    2001-04-10

    A three-dimensional (3-D) optical imaging system offering high resolution in all three dimensions, requiring minimum manipulation and capable of real-time operation, is presented. The system derives its capabilities from use of the superstructure grating laser source in the implementation of a laser step frequency radar for depth information acquisition. A synthetic aperture radar technique was also used to further enhance its lateral resolution as well as extend the depth of focus. High-speed operation was made possible by a dual computer system consisting of a host and a remote microcomputer supported by a dual-channel Small Computer System Interface parallel data transfer system. The system is capable of operating near real time. The 3-D display of a tunneling diode, a microwave integrated circuit, and a see-through image taken by the system operating near real time are included. The depth resolution is 40 mum; lateral resolution with a synthetic aperture approach is a fraction of a micrometer and that without it is approximately 10 mum.

  17. Three-Dimensional Laser Microvision

    NASA Astrophysics Data System (ADS)

    Shimotahira, Hiroshi; Iizuka, Keigo; Chu, Sun-Chun; Wah, Christopher; Costen, Furnie; Yoshikuni, Yuzo

    2001-04-01

    A three-dimensional (3-D) optical imaging system offering high resolution in all three dimensions, requiring minimum manipulation and capable of real-time operation, is presented. The system derives its capabilities from use of the superstructure grating laser source in the implementation of a laser step frequency radar for depth information acquisition. A synthetic aperture radar technique was also used to further enhance its lateral resolution as well as extend the depth of focus. High-speed operation was made possible by a dual computer system consisting of a host and a remote microcomputer supported by a dual-channel Small Computer System Interface parallel data transfer system. The system is capable of operating near real time. The 3-D display of a tunneling diode, a microwave integrated circuit, and a see-through image taken by the system operating near real time are included. The depth resolution is 40 m; lateral resolution with a synthetic aperture approach is a fraction of a micrometer and that without it is approximately 10 m.

  18. Use of the surface-based registration function of computer-aided design/computer-aided manufacturing software in medical simulation software for three-dimensional simulation of orthognathic surgery.

    PubMed

    Kang, Sang-Hoon; Lee, Jae-Won; Kim, Moon-Key

    2013-08-01

    Three-dimensional (3D) computed tomography image models are helpful in reproducing the maxillofacial area; however, they do not necessarily provide an accurate representation of dental occlusion and the state of the teeth. Recent efforts have focused on improvement of dental imaging by replacement of computed tomography with other detailed digital images. Unfortunately, despite the advantages of medical simulation software in dentofacial analysis, diagnosis, and surgical simulation, it lacks adequate registration tools. Following up on our previous report on orthognathic simulation surgery using computer-aided design/computer-aided manufacturing (CAD/CAM) software, we recently used the registration functions of a CAD/CAM platform in conjunction with surgical simulation software. Therefore, we would like to introduce a new technique, which involves use of the registration functions of CAD/CAM software followed by transfer of the images into medical simulation software. This technique may be applicable when using various registration function tools from different software platforms.

  19. Three Dimensional Display Of Meteorological Scientific Data

    NASA Astrophysics Data System (ADS)

    Grotch, Stanley L.

    1988-01-01

    Even a cursory reading of any daily newspaper shows that we are in the midst of a dramatic revolution in computer graphics. Virtually every day some new piece of hardware or software is announced, adding to the tools available to the working scientist. Three dimensional graphics form a significant part of this revolution having become virtually commonplace in advertising and on television.

  20. Three-dimen