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Sample records for advanced two-stage pressurized

  1. Sulfur removal in advanced two stage pressurized fluidized bed combustion. Technical report, December 1, 1994--February 28, 1995

    SciTech Connect

    Abbasian, J.

    1996-03-01

    The objective of this study is to obtain data on the rates and the extent of sulfation reactions involving partially sulfided calcium-based sorbents, and oxygen as well as sulfur dioxide, at operating conditions closely simulating those prevailing in the second stage (combustor) of Advanced Two-Stage Pressurized Fluidized-Bed Combustors (PFBC). In these systems the CO{sub 2} partial pressure generally exceeds the equilibrium value for calcium carbonate decomposition. Therefore, calcium sulfate is produced through the reactions between SO{sub 2} and calcium carbonate as well as the reaction between calcium sulfide and oxygen. To achieve this objective, the rates of reaction involving SO{sub 2} and oxygen (gaseous reactant); and calcium sulfide and calcium carbonate (solid reactants), will be determined by conducting tests in a pressurized thermogravimetric analyzer (HPTGA) unit. The effects of sorbent type, sorbent particle size, reactor temperature and pressure; and O{sub 2} as well as SO{sub 2} partial pressures on the sulfation reactions rate will be determined. During this quarter, samples of the selected limestone and dolomite, sulfided in the fluidized-bed reactor during last quarter, were analyzed. The extent of sulfidation in these samples was in the range of 20 to 50%, which represent carbonizer discharge material at different operating conditions. The high pressure thermogravimetric analyzer (BPTGA) unit has been modified and a new pressure control system was installed to eliminate pressure fluctuation during the sulfation tests.

  2. Sulfur removal in advanced two-staged pressurized fluidized-bed combustion; [Quarterly] report, September 1--November 1993

    SciTech Connect

    Abbasian, J.; Hill, A.H.; Wangerow, J.R.; Rue, D.M.

    1994-03-01

    The objective of this study is to obtain data on the rates of reaction between hydrogen sulfide (H{sub 2}S) and uncalcined calcium-based sorbents under operating conditions relevant to first stage (carbonizer) of Advanced Two-Stage Pressurized Fluidized-Bed Combustors (PFBC). In these systems the CO{sub 2} partial pressure in the first stage generally exceeds the equilibrium value for calcium carbonate decomposition. Therefore, removal of sulfur compounds takes place through the reaction between H{sub 2}S and calcium carbonate. To achieve this objective, the rates of reaction between hydrogen sulfide and uncalcined calcium-based sorbents will be determined by conducting tests in pressurized thermogravimetric analyzer (TGA) and high-pressure/high-temperature fluidized-bed reactor (HPTR) units. The effects of sorbent type, sorbent particle size, reactor temperature and pressure, and CO{sub 2} and H{sub 2}S partial pressures on the sulfidation reaction rate will be determined. A pressurized TGA unit has been purchased by IGT for use in this project.

  3. Sulfur removal in advanced two stage pressurized fluidized bed combustion. Technical report, 1 March--31 May 1994

    SciTech Connect

    Abbasian, J.; Chowdiah, P.; Hill, A.H.; Rue, D.M.

    1994-09-01

    The objective of this study is to obtain data on the rates of reaction between hydrogen sulfide (H{sub 2}S) and uncalcined calcium-based sorbents under operating conditions relevant to first stage (carbonizer) of Advanced Two-Stage Pressurized Fluidized-Bed Combustors (PFBC). In these systems the CO{sub 2} partial pressure in the first stage generally exceeds the equilibrium value for calcium carbonate decomposition. Therefore, removal of sulfur compounds takes place through the reaction between H{sub 2}S and calcium carbonate. To achieve this objective, the rates of reaction between hydrogen sulfide and uncalcined calcium-based sorbents will be determined by conducting tests in pressurized thermogravimetric analyzer (TGA) and high-pressure/high-temperature fluidized-bed reactor (HPTR) units. The effects of sorbent type, sorbent particle size, reactor temperature and pressure, and CO{sub 2} and H{sub 2}S partial pressures on the sulfidation reaction rate will be determined. During this quarter a series of sulfidation tests were conducted in the high-pressure/high-temperature fluidized-bed reactor (HPTR) units. The effects of sorbent type, sorbent particle size, reactor temperature and pressure, and CO{sub 2} and H{sub 2}S partial pressures on the sulfidation reaction rate will be determined. During this quarter a series of sulfidation tests were conducted in the high-pressure high-temperature thermogravimetric analyzer (HPTGA unit) using limestone and dolomite. The results suggest that half-calcined dolomite is much more reactive than uncalcined limestone. Also, temperature in the range of 800 to 950 C did not significantly affect the sulfidation reaction rates for both limestone and dolomite.

  4. Sulfur removal in advanced two stage pressurized fluidized bed combustion. Technical report, September 1--November 30, 1994

    SciTech Connect

    Abbasian, J.; Hill, A.; Wangerow, J.R.

    1994-12-31

    The objective of this study is to obtain data on the rates and the extent of sulfation reactions involving partially sulfided calcium-based sorbents, and oxygen as well as sulfur dioxide, at operating conditions closely simulating those prevailing in the second stage (combustor) of Advanced Two-Stage Pressurized Fluidized-Bed Combustors (PFBC). In these systems the CO{sub 2} partial pressure generally exceeds the equilibrium value for calcium carbonate decomposition. Therefore, calcium sulfate is produced through the reactions between SO{sub 2} and calcium carbonate as well as the reaction between calcium sulfide and oxygen. To achieve this objective, the rates of reaction involving SO{sub 2} and oxygen (gaseous reactant); and calcium sulfide and calcium carbonate (solid reactants), will be determined by conducting tests in a pressurized thermogravimetric analyzer (HPTGA) unit. The effects of sorbent type, sorbent particle size, reactor temperature and pressure; and O{sub 2} as well as SO{sub 2} partial pressures on the sulfation reactions rate will be determined. During this quarter, samples of the selected limestone and dolomite were sulfided in the fluidized-bed reactor. These tests were conducted in both calcining and non-calcining operating conditions to produce partially-sulfided sorbents containing calcium oxide and calcium carbonate, respectively. These samples which represent the carbonizer discharge material, will be used as the feed material in the sulfation tests to be conducted in the HPTGA unit during the next quarter.

  5. Sulfur removal in advanced two stage pressurized fluidized bed combustion. Technical report, March 1--May 31, 1995

    SciTech Connect

    Abbasian, J.

    1995-12-31

    The objective of this study is to obtain data on the rates and the extent of sulfation reactions involving partially sulfided calcium-based sorbents, and oxygen as well as sulfur dioxide, at operating conditions closely simulating those prevailing in the second stage (combustor) of Advanced Two-Stage Pressurized Fluidized-Bed Combustors. In these systems the CO{sub 2} partial pressure generally exceeds the equilibrium value for calcium carbonate decomposition. Therefore, calcium sulfate is produced through the reactions between SO{sub 2} and calcium carbonate as well as the reaction between calcium sulfide and oxygen. To achieve this objective, the rates of reaction involving SO{sub 2} and oxygen, calcium sulfide and calcium carbonate will be determined by conducting tests in a pressurized thermogravimetric analyzer unit. The sulfate tests conducted during this quarter, focused on the determination of the rate of sulfation reaction involving partially sulfided half-calcined dolomite and oxygen. The test parameters included CO{sub 2} and O{sub 2} concentrations, reaction temperature and pressure, as well as the sorbent particle size. The results obtained during this quarter suggest that the rate of sulfation reaction involving partially sulfided half-calcined dolomite and oxygen is very fast at temperatures above 850 C which rapidly increases with increasing temperature, achieving more than 85% conversion in less than a few minutes. The reaction appears to continue to completion, however, above 85% conversion, the rate of reaction appears to be low, requiring long residence time to reach complete conversion.

  6. Advanced two-stage incinerator

    SciTech Connect

    Rehmat, A.; Khinkis, M.

    1991-01-01

    The Institute of Gas Technology (IGT) is developing an advanced incinerator that combines the fluidized-bed agglomeration/incineration and cyclonic combustion/incineration technologies that have been developed separately at IGT over many years. This combination results in a unique and extremely flexible incinerator for solid, sludge, liquid, and gaseous wastes. This system can operate over a wide range of conditions in the first stage, from low temperature (desorption) to high temperature (agglomeration), including gasification of high-Btu wastes. In the combined system, solid, liquid, and gaseous organic wastes would be easily and efficiently destroyed (>99.99% destruction and removal efficiency (DRE)), whereas solid inorganic contaminants would be contained within a glassy matrix, rendering them benign and suitable for disposal in an ordinary landfill. This technology is different from other existing technologies because of its agglomeration and encapsulation capability and its flexibility with respect to the types wastes it can handle. Both the fluidized-bed as well as the cyclonic incineration technologies have been fully developed and tested separately at pilot scales. 12 refs., 4 figs., 4 tabs.

  7. Advanced two-stage incineration: Research and development

    SciTech Connect

    Rehmat, A.; Khinkis, M.

    1991-01-01

    IGT is currently developing a two-stage fluidized-bed/cyclonic agglomerating incineration system that is based on combining the fluidized-bed agglomeration/incineration and cyclonic combustion technologies, both of which have been developed individually at IGT over many years. This combination has resulted in a unique and extremely flexible incinerator for solid, liquid, and gaseous wastes. The system can operate over a wide range of conditions in the first stage, from low temperature (desorption) to high temperature (agglomeration), including gasification of high-Btu wastes. In the combined system, solid, liquid, and gaseous organic wastes are expected to be easily and efficiently destroyed (>99.99% destruction and removal efficiency (DRE)) while solid inorganic contaminants are expected to be contained within a glassy matrix, rendering them benign and suitable for disposal in an ordinary landfill. The development of the two-stage incinerator is a culmination of extensive research and development efforts on each stage of the incinerator. A variety of data obtained for both stages includes agglomeration of ash, incineration and reclamation of used blast grit and foundry sand, partial combustion of carbonaceous fuels, in-situ desulfurization, combustion of low-Btu gases, incineration of industrial wastewater, and incineration of carbon tetrachloride.

  8. Two-stage, low noise advanced technology fan. 5: Acoustic final report

    NASA Technical Reports Server (NTRS)

    Sofrin, T. G.; Riloff, N., Jr.

    1975-01-01

    The NASA Q2S(quiet two-stage) fan is a 0.836m (32.9 in.) diameter model of the STF 433 engine fan, selected in a 1972 study for an Advanced Technology Transport (ATT) airplane. Noise-control features include: low tip speed, moderate stage pressure rise, large blade-vane spacings, no inlet guide vanes, and optimum blade and vane numbers. Tests were run on the baseline Q2S fan with standard inlet and discharge ducts. Further tests were made of a translating centerbody sonic inlet device and treated discharge ducts. Results were scaled to JT8D and JT3D engine fan size for comparison with current two-stage fans, and were also scaled to STF 433 fan size to compare calculated ATT flyover noise with FAR 36 limits. Baseline Q2S results scaled to JT8D and JT3D engine fan sizes showed substantial noise reductions. Calculated unsuppressed baseline ATT flyovers averaged about 2.5 EPNdB below FAR 36 limits. Using measured sonic inlet results, scaled baseline Q2S fan results, and calculated attenuations for a 1975 technology duct liner, projected flyover noise calculations for the ATT averaged about FAR 36 limits minus 10 EPNdB. Advances in suppression technology required to meet the 1985 goal of FAR 36 limits minus 20 EPNdB are discussed.

  9. High pressure studies using two-stage diamond micro-anvils grown by chemical vapor deposition

    SciTech Connect

    Vohra, Yogesh K.; Samudrala, Gopi K.; Moore, Samuel L.; Montgomery, Jeffrey M.; Tsoi, Georgiy M.; Velisavljevic, Nenad

    2015-06-10

    Ultra-high static pressures have been achieved in the laboratory using a two-stage micro-ball nanodiamond anvils as well as a two-stage micro-paired diamond anvils machined using a focused ion-beam system. The two-stage diamond anvils’ designs implemented thus far suffer from a limitation of one diamond anvil sliding past another anvil at extreme conditions. We describe a new method of fabricating two-stage diamond micro-anvils using a tungsten mask on a standard diamond anvil followed by microwave plasma chemical vapor deposition (CVD) homoepitaxial diamond growth. A prototype two stage diamond anvil with 300 μm culet and with a CVD diamond second stage of 50 μm in diameter was fabricated. We have carried out preliminary high pressure X-ray diffraction studies on a sample of rare-earth metal lutetium sample with a copper pressure standard to 86 GPa. Furthermore, the micro-anvil grown by CVD remained intact during indentation of gasket as well as on decompression from the highest pressure of 86 GPa.

  10. High pressure studies using two-stage diamond micro-anvils grown by chemical vapor deposition

    DOE PAGES

    Vohra, Yogesh K.; Samudrala, Gopi K.; Moore, Samuel L.; Montgomery, Jeffrey M.; Tsoi, Georgiy M.; Velisavljevic, Nenad

    2015-06-10

    Ultra-high static pressures have been achieved in the laboratory using a two-stage micro-ball nanodiamond anvils as well as a two-stage micro-paired diamond anvils machined using a focused ion-beam system. The two-stage diamond anvils’ designs implemented thus far suffer from a limitation of one diamond anvil sliding past another anvil at extreme conditions. We describe a new method of fabricating two-stage diamond micro-anvils using a tungsten mask on a standard diamond anvil followed by microwave plasma chemical vapor deposition (CVD) homoepitaxial diamond growth. A prototype two stage diamond anvil with 300 μm culet and with a CVD diamond second stage ofmore » 50 μm in diameter was fabricated. We have carried out preliminary high pressure X-ray diffraction studies on a sample of rare-earth metal lutetium sample with a copper pressure standard to 86 GPa. Furthermore, the micro-anvil grown by CVD remained intact during indentation of gasket as well as on decompression from the highest pressure of 86 GPa.« less

  11. Two-stage, low noise advanced technology fan. Volume 2: Aerodynamic data

    NASA Technical Reports Server (NTRS)

    Harley, K. G.; Odegard, P. A.

    1975-01-01

    Aerodynamic data from static tests of a two-stage advanced technology fan designed to minimize noise are presented. Fan design conditions include delivery of 209.1kg/sec/sq m (42.85 lbm/sec/sq ft) specific corrected flow at an overall pressure ratio of 1.9 and an adiabatic efficiency of 85.3 percent. The 0.836m (2.74ft) diameter first stage rotor has a hub/tip ratio of 0.4 and 365.8m/sec (1200ft/sec) design tip speed. In addition to the moderate tip speed and pressure rise per stage, other noise control design features involve widely spaced blade rows and proper selection of blade-vane ratios. Aerodynamic data are presented for tests with unifrom and with hub and tip radially distorted inlet flow. Aerodynamic data are also presented for tests of this fan with acoustic treatments, including acoustically treated casing walls, a flowpath exit acoustic ring, and a translating centerbody sonic inlet device. A complete tabulation of the overall performance data, the blade element data, and the power spectral density information relating to turbulence levels generated by the sonic inlet obtained during these tests is included. For vol. 1, see N74-33789.

  12. Static Pressure Above 300 GPa Using Chemical Vapor Deposited Two-stage Diamond Micro-anvils

    NASA Astrophysics Data System (ADS)

    Montgomery, Jeffrey; Samudrala, Gopi; Tsoi, Georgiy; Smith, Spencer; Vohra, Yogesh

    Two-stage diamond micro-anvils were grown via chemical vapor deposition (CVD) on beveled diamond anvils with 30 micron central flats. These anvils were used to compress a pre-indented rhenium foil to pressures in excess of 300 Gigapascals (GPa) at relatively small applied loads. Powder diffraction patterns were collected across the high-pressure region using an x-ray beam collimated to 1x2 microns in a grid with a spacing of 1 micron. While multi-megabar pressures were seen across the entire second stage, the highest pressure regions were confined to areas of a few microns in diameter. These were observed at points near the edge of the second stage with nearby pressure gradients as high as 100 GPa/micron. The transmitted x-rays show that the second stage plastically deformed while maintaining multi-megabar pressures. This may have created a second-stage gasket consisting of CVD diamond and rhenium that supported the pressure gradient without substantial external confining pressure. Further improvements in two-stage diamond micro-anvils would require controlling the geometry and microcrystalline/nanocrystalline diamond content during CVD growth process. This work was supported by the Department of Energy (DOE), National Nuclear Security Administration under Grant Number DE-NA0002014.

  13. Effect of casing treatment on performance of a two-stage high-pressure-ratio fan

    NASA Technical Reports Server (NTRS)

    Urasek, D. C.

    1979-01-01

    A two-stage fan, previously tested with a solid casing, was tested with a casing with circumferential grooves over the tips of both rotors (casing treatment). Tests were conducted at 80 and 100 percent of design speed with uniform flow. The casing treatment improved the flow range and stall margin significantly without changing the characteristics overall performance curves of total-pressure and efficiency as functions of weight flow, other than extending them to lower weight flows.

  14. A Two Stage Solution Procedure for Production Planning System with Advance Demand Information

    NASA Astrophysics Data System (ADS)

    Ueno, Nobuyuki; Kadomoto, Kiyotaka; Hasuike, Takashi; Okuhara, Koji

    We model for ‘Naiji System’ which is a unique corporation technique between a manufacturer and suppliers in Japan. We propose a two stage solution procedure for a production planning problem with advance demand information, which is called ‘Naiji’. Under demand uncertainty, this model is formulated as a nonlinear stochastic programming problem which minimizes the sum of production cost and inventory holding cost subject to a probabilistic constraint and some linear production constraints. By the convexity and the special structure of correlation matrix in the problem where inventory for different periods is not independent, we propose a solution procedure with two stages which are named Mass Customization Production Planning & Management System (MCPS) and Variable Mesh Neighborhood Search (VMNS) based on meta-heuristics. It is shown that the proposed solution procedure is available to get a near optimal solution efficiently and practical for making a good master production schedule in the suppliers.

  15. Exprimental Results of the First Two Stages of an Advanced Transonic Core Compressor Under Isolated and Multi-Stage Conditions.

    NASA Technical Reports Server (NTRS)

    Prahst, Patricia S.; Kulkarni, Sameer; Sohn, Ki H.

    2015-01-01

    NASA's Environmentally Responsible Aviation (ERA) Program calls for investigation of the technology barriers associated with improved fuel efficiency for large gas turbine engines. Under ERA, the highly loaded core compressor technology program attempts to realize the fuel burn reduction goal by increasing overall pressure ratio of the compressor to increase thermal efficiency of the engine. Study engines with overall pressure ratio of 60 to 70 are now being investigated. This means that the high pressure compressor would have to almost double in pressure ratio while keeping a high level of efficiency. NASA and GE teamed to address this challenge by testing the first two stages of an advanced GE compressor designed to meet the requirements of a very high pressure ratio core compressor. Previous test experience of a compressor which included these front two stages indicated a performance deficit relative to design intent. Therefore, the current rig was designed to run in 1-stage and 2-stage configurations in two separate tests to assess whether the bow shock of the second rotor interacting with the upstream stage contributed to the unpredicted performance deficit, or if the culprit was due to interaction of rotor 1 and stator 1. Thus, the goal was to fully understand the stage 1 performance under isolated and multi-stage conditions, and additionally to provide a detailed aerodynamic data set for CFD validation. Full use was made of steady and unsteady measurement methods to understand fluid dynamics loss source mechanisms due to rotor shock interaction and endwall losses. This paper will present the description of the compressor test article and its measured performance and operability, for both the single stage and two stage configurations. We focus the paper on measurements at 97% corrected speed with design intent vane setting angles.

  16. Study of Boundary Layer Development in a Two-Stage Low-Pressure Turbine

    NASA Technical Reports Server (NTRS)

    Dorney, Daniel J.; Ashpis, David E.; Halstead, David E.; Wisler, David C.

    1999-01-01

    Experimental data from jet-engine tests have indicated that unsteady blade row interactions and separation can have a significant impact on the efficiency of low-pressure turbine stages. Measured turbine efficiencies at takeoff can be as much as two points higher than those at cruise conditions. Several recent studies have revealed that Reynolds number effects may contribute to the lower efficiencies at cruise conditions. In the current study numerical simulations have been performed to study the boundary layer development in a two-stage low-pressure turbine, and to evaluate the transition models available for low Reynolds number flows in turbomachinery. The results of the simulations have been compared with experimental data, including airfoil loadings and integral boundary layer quantities. The predicted unsteady results display similar trends to the experimental data, but significantly overestimate the amplitude of the unsteadiness. The time-averaged results show close agreement with the experimental data.

  17. Heat transfer and pressure measurements and comparison with prediction for the SSME two-stage turbine

    NASA Technical Reports Server (NTRS)

    Dunn, M. G.; Kim, J.

    1992-01-01

    Time averaged Stanton number and surface pressure distributions are reported for the first stage vane row, the first stage blade row, and the second stage vane row of the Rocketdyne Space Shuttle Main Engine (SSME) two-stage fuel-side turbine. Unsteady pressure envelope measurements for the first blade are also reported. These measurements were made at 10 percent, 50 percent, and 90 percent span on both the pressure and suction surfaces of the first stage components. Additional Stanton number measurements were made on the first stage blade platform, blade tip, and shroud, and at 50 percent span on the second vane. A shock tube was used as a short duration source of heated and pressurized air to which the turbine was subjected. Platinum thin film heat flux gages were used to obtain the heat flux measurements, while miniature silicon diaphragm flush-mounted pressure transducers were used to obtain the pressure measurements. The first stage vane Stanton number distributions are compared with predictions obtained using a version of STAN5 and quasi-3D Navier-Stokes solution. This same quasi-3D N-S code was also used to obtain predictions for the first blade and the second vane.

  18. Design and development of an advanced two-stage centrifugal compressor

    SciTech Connect

    Palmer, D.L.; Waterman, W.F.

    1995-04-01

    Small turboshaft engines require high-pressure-ratio, high-efficiency compressors to provide low engine fuel consumption. This paper describes the aeromechanical design and development of a 3.3 kg/s (7.3 lb/sec), 14:1 pressure ratio two-stage centrifugal compressor, which is used in the T800-LHT-800 helicopter engine. The design employs highly nonradial, splitter bladed impellers with swept leading edges and compact vaned diffusers to achieve high performance in a small and robust configuration. The development effort quantified the effects of impeller diffusion and passive inducer shroud bleed on surge margin as well as the effects of impeller loading on tip clearance sensitivity and the impact of sand erosion and shroud roughness on performance. The developed compressor exceeded its performance objectives with a minimum of 23% surge margin without variable geometry. The compressor provides a high-performance, rugged, low-cost configuration ideally suited for helicopter applications.

  19. Sulfur removal in advanced two-stage fluidized-bed combustion. [Quarterly] technical report, December 1, 1993--February 28, 1994

    SciTech Connect

    Abbasian, J.; Hill, A.H.; Wangerow, J.R.; Rue, D.M.

    1994-06-01

    The objective of this study is to obtain data on the rates of reaction between, hydrogen sulfide (H{sub 2}S) and uncalcined calcium-based sorbents under operating conditions relevant to first stage (carbonizer) of Advanced Two-Stage Pressurized Fluidized-Bed Combustors (PFBC). In these systems the CO{sub 2} partial pressure in the first stage generally exceeds the equilibrium value for calcium carbonate decomposition. Therefore, removal of sulfur compounds takes place through the reaction between H{sub 2}S and calcium carbonate. To achieve this objective the rates of reaction between hydrogen sulfide and uncalcined calcium-based sorbents will be determined by conducting tests in pressurized thermogravimetric analyzer (TGA) and high-pressure/high-temperature fluidized-bed reactor (HPTR) units. The effects of sorbent type, sorbent particle size, reactor temperature and pressure, and CO{sub 2} and H{sub 2}S partial pressures on the sulfidation reaction rate will be determined. During this quarter, the high-pressure thermogravimetric analyzer (HPTGA) unit was installed and the shakedown process was completed. Several tests were conducted in the HPTGA unit to establish the operating procedure and the repeatability of the experimental results. Sulfidation by conducting the baseline sulfidation tests. The results are currently being analyzed.

  20. Two stage low noise advanced technology fan. 1: Aerodynamic, structural, and acoustic design

    NASA Technical Reports Server (NTRS)

    Messenger, H. E.; Ruschak, J. T.; Sofrin, T. G.

    1974-01-01

    A two-stage fan was designed to reduce noise 20 db below current requirements. The first-stage rotor has a design tip speed of 365.8 m/sec and a hub/tip ratio of 0.4. The fan was designed to deliver a pressure ratio of 1.9 with an adiabatic efficiency of 85.3 percent at a specific inlet corrected flow of 209.2kg/sec/sq m. Noise reduction devices include acoustically treated casing walls, a flowpath exit acoustic splitter, a translating centerbody sonic inlet device, widely spaced blade rows, and the proper ratio of blades and vanes. Multiple-circular-arc rotor airfoils, resettable stators, split outer casings, and capability to go to close blade-row spacing are also included.

  1. Phase-resolved surface pressure and heat-transfer measurements on the blade of a two-stage turbine

    SciTech Connect

    Dunn, M.G.; Haldeman, C.W. Jr.

    1995-12-01

    Phase-resolved surface pressure, and unsteady pressure measurements are reported for the first-stage blade row of the Space Shuttle Main Engine two-stage fuel-side turbine. Measurements were made at 10, 50, and 90 percent span on both the pressure and suction surfaces of the blade. Phase-resolved and unsteady heat-flux measurements are also reported.

  2. Experimental Results of the First Two Stages of an Advanced Transonic Core Compressor Under Isolated and Multi-Stage Conditions

    NASA Technical Reports Server (NTRS)

    Prahst, Patricia S.; Kulkarni, Sameer; Sohn, Ki H.

    2015-01-01

    NASA's Environmentally Responsible Aviation (ERA) Program calls for investigation of the technology barriers associated with improved fuel efficiency of large gas turbine engines. Under ERA the task for a High Pressure Ratio Core Technology program calls for a higher overall pressure ratio of 60 to 70. This mean that the HPC would have to almost double in pressure ratio and keep its high level of efficiency. The challenge is how to match the corrected mass flow rate of the front two supersonic high reaction and high corrected tip speed stages with a total pressure ratio of 3.5. NASA and GE teamed to address this challenge by using the initial geometry of an advanced GE compressor design to meet the requirements of the first 2 stages of the very high pressure ratio core compressor. The rig was configured to run as a 2 stage machine, with Strut and IGV, Rotor 1 and Stator 1 run as independent tests which were then followed by adding the second stage. The goal is to fully understand the stage performances under isolated and multi-stage conditions and fully understand any differences and provide a detailed aerodynamic data set for CFD validation. Full use was made of steady and unsteady measurement methods to isolate fluid dynamics loss source mechanisms due to interaction and endwalls. The paper will present the description of the compressor test article, its predicted performance and operability, and the experimental results for both the single stage and two stage configurations. We focus the detailed measurements on 97 and 100 of design speed at 3 vane setting angles.

  3. Influence of different substrates on the performance of a two-stage high pressure anaerobic digestion system.

    PubMed

    Lemmer, A; Chen, Y; Lindner, J; Wonneberger, A M; Zielonka, S; Oechsner, H; Jungbluth, T

    2015-02-01

    The two-stage autogenerative high-pressure digestion technique is a novel and promising approach for the production of gaseous fuels or upgraded biogas. This new technique is described in the patent DE 10 2011 015415 A1 and integrates biogas production, its upgrading and pressure boosting in one process. Anaerobic digestion under elevated pressure conditions leads to decreasing pH-values in the digestate due to the augmented formation of carboxylic acid. Model calculations carried out to evaluate the two-stage design showed that the pH-value in the pressurized anaerobic filter has a major influence on the methane content of the biogas produced. Within this study, the influence of the nitrogen content as one of the most important buffering substances on the performance of the system has been tested. The results show that higher NH4 contents lead to higher pH-values in the digester and as a consequence to higher methane contents.

  4. Two-Stage Axial Compressor Rig Designed To Develop and Validate Advanced Aerodynamic Technologies

    NASA Technical Reports Server (NTRS)

    Larosiliere, Louis M.

    2003-01-01

    Future aeropropulsion gas turbine engines must be affordable in addition to being energy efficient and environmentally benign. Progress in aerodynamic design capability is required not only to maximize the specific thrust of next-generation engines without sacrificing fuel consumption, but also to reduce parts count by increasing the aerodynamic loading of the compression system. To meet future compressor requirements, the NASA Glenn Research Center is investigating advanced aerodynamic design concepts that will lead to more compact, higher efficiency, and wider operability configurations than are currently in operation.

  5. Optimization of two-stage production/inventory systems under order base stock policy with advance demand information

    NASA Astrophysics Data System (ADS)

    Nakade, Koichi; Yokozawa, Shiori

    2016-08-01

    It is important to share demand information among the members in supply chains. In recent years, production and inventory systems with advance demand information (ADI) have been discussed, where advance demand information means the information of demand which the decision maker obtains before the corresponding actual demand arrives. Appropriate production and inventory control using demand information leads to the decrease of inventory and backlog costs. For a single stage system, the optimal base stock and release lead time have been discussed in the literature. In practical production systems the manufacturing system has multiple processes. The multiple stage production and inventory system with ADI, however, has been analyzed by simulation or assuming exponential processing time. That is, their theoretical analysis and optimization of release lead time and base stock level have little been obtained because of its difficulty. In this paper, theoretical analysis of a two-stage production inventory system with advance demand information is developed, where the processing time is assumed deterministic and identical; demand arrival process is Poisson, and an order base stock policy is adopted. Using the analytical results, optimal release lead time and optimal base stock levels for minimizing the average cost on the holding and backlog costs are explicitly derived.

  6. Results of Two-Stage Light-Gas Gun Development Efforts and Hypervelocity Impact Tests of Advanced Thermal Protection Materials

    NASA Technical Reports Server (NTRS)

    Cornelison, C. J.; Watts, Eric T.

    1998-01-01

    Gun development efforts to increase the launching capabilities of the NASA Ames 0.5-inch two-stage light-gas gun have been investigated. A gun performance simulation code was used to guide initial parametric variations and hardware modifications, in order to increase the projectile impact velocity capability to 8 km/s, while maintaining acceptable levels of gun barrel erosion and gun component stresses. Concurrent with this facility development effort, a hypervelocity impact testing series in support of the X-33/RLV program was performed in collaboration with Rockwell International. Specifically, advanced thermal protection system materials were impacted with aluminum spheres to simulate impacts with on-orbit space debris. Materials tested included AETB-8, AETB-12, AETB-20, and SIRCA-25 tiles, tailorable advanced blanket insulation (TABI), and high temperature AFRSI (HTA). The ballistic limit for several Thermal Protection System (TPS) configurations was investigated to determine particle sizes which cause threshold TPS/structure penetration. Crater depth in tiles was measured as a function of impact particle size. The relationship between coating type and crater morphology was also explored. Data obtained during this test series was used to perform a preliminary analysis of the risks to a typical orbital vehicle from the meteoroid and space debris environment.

  7. Design and performance of a 427-meter-per-second-tip-speed two-stage fan having a 2.40 pressure ratio

    NASA Technical Reports Server (NTRS)

    Cunnan, W. S.; Stevans, W.; Urasek, D. C.

    1978-01-01

    The aerodynamic design and the overall and blade-element performances are presented of a 427-meter-per-second-tip-speed two-stage fan designed with axially spaced blade rows to reduce noise transmitted upstream of the fan. At design speed the highest recorded adiabatic efficiency was 0.796 at a pressure of 2.30. Peak efficiency was not established at design speed because of a damper failure which terminated testing prematurely. The overall efficiencies, at 60 and 80 percent of design speed, peaked at approximately 0.83.

  8. A two stage launch vehicle for use as an advanced space transportation system for logistics support of the space station

    NASA Technical Reports Server (NTRS)

    1987-01-01

    This report describes the preliminary design specifications for an Advanced Space Transportation System consisting of a fully reusable flyback booster, an intermediate-orbit cargo vehicle, and a shuttle-type orbiter with an enlarged cargo bay. It provides a comprehensive overview of mission profile, aerodynamics, structural design, and cost analyses. These areas are related to the overall feasibility and usefullness of the proposed system.

  9. Two stages splicing system

    NASA Astrophysics Data System (ADS)

    Mudaber, Mohammad Hassan; Yusof, Yuhani

    2015-05-01

    The study of the biological process of deoxyribonucleic acid (DNA) splicing system in a translucent approach was investigated in 2012 by Yusof under the framework of formal language theory. In this work, the concepts of splicing system in two stages as well as splicing languages are mathematically and biologically discussed. Additionally, some theorems based on recognition site factor of initial strings at the existence of two initial strings and two rules are provided via Yusof-Goode (Y-G) approach. Besides, an example is also given in showing the biological meaning of the introduced concept.

  10. Two stage liquefaction of coal

    DOEpatents

    Neuworth, Martin B.

    1981-01-01

    A two stage coal liquefaction process and apparatus comprising hydrogen donor solvent extracting, solvent deashing, and catalytic hydrocracking. Preferrably, the catalytic hydrocracking is performed in an ebullating bed hydrocracker.

  11. Two-Stage Mucogingival Surgery with Free Gingival Autograft and Biomend Membrane and Coronally Advanced Flap in Treatment of Class III Millers Recession.

    PubMed

    Rath, Avita; Varma, Smrithi; Paul, Renny

    2016-01-01

    Introduction. Gingival recession is an apical shift of the gingival margin with exposure of the root surface. This migration of the marginal tissue leads to esthetic concerns, dentin hypersensitivity, root caries, and cervical wear. It is, paradoxically, a common finding in patients with a high standard of oral hygiene, as well as in periodontally untreated populations with poor oral hygiene. Changing the topography of the marginal soft tissue in order to facilitate plaque control is a common indication for root coverage procedures and forms a major aspect of periodontal plastic surgeries. The regeneration of a new connective tissue attachment to denuded root surface is by allowing the selective coronal regrowth of periodontal ligament cells while excluding the gingival tissues from the root during wound healing by means of a barrier membrane. Case Presentation. This case reports a two-stage surgical technique for treatment of Miller's class III defect using free gingival autograft and type I absorbable collagen membrane (BioMend®, Zimmer Dental, USA)(§). Conclusions. The 6-month follow-up of the case showed a significant increase in attached gingiva suggesting it as a predictable alternative in the treatment of Millers class III defects. PMID:27525131

  12. Two-Stage Mucogingival Surgery with Free Gingival Autograft and Biomend Membrane and Coronally Advanced Flap in Treatment of Class III Millers Recession

    PubMed Central

    Paul, Renny

    2016-01-01

    Introduction. Gingival recession is an apical shift of the gingival margin with exposure of the root surface. This migration of the marginal tissue leads to esthetic concerns, dentin hypersensitivity, root caries, and cervical wear. It is, paradoxically, a common finding in patients with a high standard of oral hygiene, as well as in periodontally untreated populations with poor oral hygiene. Changing the topography of the marginal soft tissue in order to facilitate plaque control is a common indication for root coverage procedures and forms a major aspect of periodontal plastic surgeries. The regeneration of a new connective tissue attachment to denuded root surface is by allowing the selective coronal regrowth of periodontal ligament cells while excluding the gingival tissues from the root during wound healing by means of a barrier membrane. Case Presentation. This case reports a two-stage surgical technique for treatment of Miller's class III defect using free gingival autograft and type I absorbable collagen membrane (BioMend®, Zimmer Dental, USA)§. Conclusions. The 6-month follow-up of the case showed a significant increase in attached gingiva suggesting it as a predictable alternative in the treatment of Millers class III defects. PMID:27525131

  13. Two-Stage Phase I Dose-Escalation Study of Intratumoral Reovirus Type 3 Dearing and Palliative Radiotherapy in Patients with Advanced Cancers

    PubMed Central

    Harrington, Kevin J.; Karapanagiotou, Eleni M.; Roulstone, Victoria; Twigger, Katie R.; White, Christine L.; Vidal, Laura; Beirne, Debbie; Prestwich, Robin; Newbold, Kate; Ahmed, Merina; Thway, Khin; Nutting, Christopher M.; Coffey, Matt; Harris, Dean; Vile, Richard G.; Pandha, Hardev S.; DeBono, Johann S.; Melcher, Alan A.

    2013-01-01

    Purpose To determine the safety and feasibility of combining intratumoral reovirus and radiotherapy in patients with advanced cancer and to assess viral biodistribution, reoviral replication in tumors, and antiviral immune responses. Experimental Design Patients with measurable disease amenable to palliative radiotherapy were enrolled. In the first stage, patients received radiotherapy (20 Gy in five fractions) plus two intratumoral injections of RT3D at doses between 1 × 108 and 1 × 1010 TCID50. In the second stage, the radiotherapy dose was increased (36 Gy in 12 fractions) and patients received two, four, or six doses of RT3D at 1 × 1010 TCID50. End points were safety, viral replication, immunogenicity, and antitumoral activity. Results Twenty-three patients with various solid tumors were treated. Dose-limiting toxicity was not seen. The most common toxicities were grade 2 (or lower) pyrexia, influenza-like symptoms, vomiting, asymptomatic lymphopenia, and neutropenia. There was no exacerbation of the acute radiation reaction. Reverse transcription-PCR (RT-PCR) studies of blood, urine, stool, and sputum were negative for viral shedding. In the low-dose (20 Gy in five fractions) radiation group, two of seven evaluable patients had a partial response and five had stable disease. In the high-dose (36 Gy in 12 fractions) radiation group, five of seven evaluable patients had partial response and two stable disease. Conclusions The combination of intratumoral RT3D and radiotherapy was well tolerated. The favorable toxicity profile and lack of vector shedding means that this combination should be evaluated in newly diagnosed patients receiving radiotherapy with curative intent. PMID:20484020

  14. Two stage to orbit design

    NASA Technical Reports Server (NTRS)

    1991-01-01

    A preliminary design of a two-stage to orbit vehicle was conducted with the requirements to carry a 10,000 pound payload into a 300 mile low-earth orbit using an airbreathing first stage, and to take off and land unassisted on a 15,000 foot runway. The goal of the design analysis was to produce the most efficient vehicle in size and weight which could accomplish the mission requirements. Initial parametric analysis indicated that the weight of the orbiter and the transonic performance of the system were the two parameters that had the largest impact on the design. The resulting system uses a turbofan ramjet powered first stage to propel a scramjet and rocket powered orbiter to the stage point of Mach 6 to 6.5 at an altitude of 90,000 ft.

  15. Two stage indirect evaporative cooling system

    DOEpatents

    Bourne, Richard C.; Lee, Brian E.; Callaway, Duncan

    2005-08-23

    A two stage indirect evaporative cooler that moves air from a blower mounted above the unit, vertically downward into dry air passages in an indirect stage and turns the air flow horizontally before leaving the indirect stage. After leaving the dry passages, a major air portion travels into the direct stage and the remainder of the air is induced by a pressure drop in the direct stage to turn 180.degree. and returns horizontally through wet passages in the indirect stage and out of the unit as exhaust air.

  16. Adaptive two-stage designs in phase II clinical trials.

    PubMed

    Banerjee, Anindita; Tsiatis, Anastasios A

    2006-10-15

    Two-stage designs have been widely used in phase II clinical trials. Such designs are desirable because they allow a decision to be made on whether a treatment is effective or not after the accumulation of the data at the end of each stage. Optimal fixed two-stage designs, where the sample size at each stage is fixed in advance, were proposed by Simon when the primary outcome is a binary response. This paper proposes an adaptive two-stage design which allows the sample size at the second stage to depend on the results at the first stage. Using a Bayesian decision-theoretic construct, we derive optimal adaptive two-stage designs; the optimality criterion being minimum expected sample size under the null hypothesis. Comparisons are made between Simon's two-stage fixed design and the new design with respect to this optimality criterion. PMID:16479547

  17. Two-Stage Centrifugal Fan

    NASA Technical Reports Server (NTRS)

    Converse, David

    2011-01-01

    Fan designs are often constrained by envelope, rotational speed, weight, and power. Aerodynamic performance and motor electrical performance are heavily influenced by rotational speed. The fan used in this work is at a practical limit for rotational speed due to motor performance characteristics, and there is no more space available in the packaging for a larger fan. The pressure rise requirements keep growing. The way to ordinarily accommodate a higher DP is to spin faster or grow the fan rotor diameter. The invention is to put two radially oriented stages on a single disk. Flow enters the first stage from the center; energy is imparted to the flow in the first stage blades, the flow is redirected some amount opposite to the direction of rotation in the fixed stators, and more energy is imparted to the flow in the second- stage blades. Without increasing either rotational speed or disk diameter, it is believed that as much as 50 percent more DP can be achieved with this design than with an ordinary, single-stage centrifugal design. This invention is useful primarily for fans having relatively low flow rates with relatively high pressure rise requirements.

  18. Two stage sorption type cryogenic refrigerator including heat regeneration system

    NASA Technical Reports Server (NTRS)

    Jones, Jack A. (Inventor); Wen, Liang-Chi (Inventor); Bard, Steven (Inventor)

    1989-01-01

    A lower stage chemisorption refrigeration system physically and functionally coupled to an upper stage physical adsorption refrigeration system is disclosed. Waste heat generated by the lower stage cycle is regenerated to fuel the upper stage cycle thereby greatly improving the energy efficiency of a two-stage sorption refrigerator. The two stages are joined by disposing a first pressurization chamber providing a high pressure flow of a first refrigerant for the lower stage refrigeration cycle within a second pressurization chamber providing a high pressure flow of a second refrigerant for the upper stage refrigeration cycle. The first pressurization chamber is separated from the second pressurization chamber by a gas-gap thermal switch which at times is filled with a thermoconductive fluid to allow conduction of heat from the first pressurization chamber to the second pressurization chamber.

  19. Impact of osmotic pressure and gelling in the generation of highly stable single core water-in-oil-in-water (W/O/W) nano multiple emulsions of aspirin assisted by two-stage ultrasonic cavitational emulsification.

    PubMed

    Tang, Siah Ying; Sivakumar, Manickam; Nashiru, Billa

    2013-02-01

    The present investigation focuses in investigating the effect of osmotic pressure, gelling on the mean droplet diameter, polydispersity index, droplet size stability of the developed novel Aspirin containing water-in-oil-in-water (W/O/W) nano multiple emulsion. The aspirin-loaded nano multiple emulsion formulation was successfully generated using two-stage ultrasonic cavitational emulsification which had been reported in author's previous study. The osmotic behavior of ultrasonically prepared nano multiple emulsions were also examined with different glucose concentrations both in the inner and outer aqueous phases. In addition, introducing gelatin into the formulation also observed to play an important role in preventing the interdroplet coalescence via the formation of interfacial rigid film. Detailed studies were also made on the possible mechanisms of water migration under osmotic gradient which primarily caused by the permeation of glucose. Besides, the experimental results have shown that the interfacial tension between the two immiscible phases decreases with varying the composition of organic phase. Although the W/O/W emulsion prepared with the inner/outer glucose weight ratio of 1-0.5% (w/w) showed an excellent droplet stability, the formulation containing 0.5% (w/w) glucose in the inner aqueous phase appeared to be the most stable with minimum change in the mean droplet size upon one-week storage period. Based on the optimization, nano multiple emulsion droplets with the mean droplet diameter of around 400 nm were produced using 1.25% (w/w) Span 80 and 0.5% Cremophore EL. Overall, our investigation makes a pathway in proving that the use of ultrasound cavitation is an efficient yet promising approach in the generation of stable and uniform nano multiple emulsions and could be used in the encapsulation of various active pharmaceutical ingredients in the near future. PMID:23107943

  20. Two-stage hybrid microcircuit amplifier

    SciTech Connect

    Pyo, M.L.

    1987-04-01

    This report documents the design, development, and fabrication of a two-stage amplifier operating at 400 to 600 MHz. Included are characterization data, predictions generated during design, and measured performance.

  1. Two-stage coal liquefaction process

    DOEpatents

    Skinner, Ronald W.; Tao, John C.; Znaimer, Samuel

    1985-01-01

    An improved SRC-I two-stage coal liquefaction process which improves the product slate is provided. Substantially all of the net yield of 650.degree.-850.degree. F. heavy distillate from the LC-Finer is combined with the SRC process solvent, substantially all of the net 400.degree.-650.degree. F. middle distillate from the SRC section is combined with the hydrocracker solvent in the LC-Finer, and the initial boiling point of the SRC process solvent is increased sufficiently high to produce a net yield of 650.degree.-850.degree. F. heavy distillate of zero for the two-stage liquefaction process.

  2. Two stage sorption of sulfur compounds

    SciTech Connect

    Moore, W.E.

    1991-12-31

    A two stage method for reducing the sulfur content of exhaust gases is disclosed. Alkali- or alkaline-earth-based sorbent is totally or partially vaporized 10 and introduced into a sulfur-containing gas stream. The activated sorbent can be introduced in the reaction zone or the exhaust gases of a combustor or a gasifier. High efficiencies of sulfur removal can be achieved.

  3. Two stage sorption of sulfur compounds

    DOEpatents

    Moore, William E.

    1992-01-01

    A two stage method for reducing the sulfur content of exhaust gases is disclosed. Alkali- or alkaline-earth-based sorbent is totally or partially vaporized and introduced into a sulfur-containing gas stream. The activated sorbent can be introduced in the reaction zone or the exhaust gases of a combustor or a gasifier. High efficiencies of sulfur removal can be achieved.

  4. Two stage principal component analysis of color.

    PubMed

    Lenz, Reiner

    2002-01-01

    We introduce a two-stage analysis of color spectra. In the first processing stage, correlation with the first eigenvector of a spectral database is used to measure the intensity of a color spectrum. In the second step, a perspective projection is used to map the color spectrum to the hyperspace of spectra with first eigenvector coefficient equal to unity. The location in this hyperspace describes the chromaticity of the color spectrum. In this new projection space, a second basis of eigenvectors is computed and the projected spectrum is described by the expansion in this chromaticity basis. This description is possible since the space of color spectra is conical. We compare this two-stage process with traditional principal component analysis and find that the results of the new structure are closer to the structure of traditional chromaticity descriptors than traditional principal component analysis.

  5. Two-stage microbial community experimental design.

    PubMed

    Tickle, Timothy L; Segata, Nicola; Waldron, Levi; Weingart, Uri; Huttenhower, Curtis

    2013-12-01

    Microbial community samples can be efficiently surveyed in high throughput by sequencing markers such as the 16S ribosomal RNA gene. Often, a collection of samples is then selected for subsequent metagenomic, metabolomic or other follow-up. Two-stage study design has long been used in ecology but has not yet been studied in-depth for high-throughput microbial community investigations. To avoid ad hoc sample selection, we developed and validated several purposive sample selection methods for two-stage studies (that is, biological criteria) targeting differing types of microbial communities. These methods select follow-up samples from large community surveys, with criteria including samples typical of the initially surveyed population, targeting specific microbial clades or rare species, maximizing diversity, representing extreme or deviant communities, or identifying communities distinct or discriminating among environment or host phenotypes. The accuracies of each sampling technique and their influences on the characteristics of the resulting selected microbial community were evaluated using both simulated and experimental data. Specifically, all criteria were able to identify samples whose properties were accurately retained in 318 paired 16S amplicon and whole-community metagenomic (follow-up) samples from the Human Microbiome Project. Some selection criteria resulted in follow-up samples that were strongly non-representative of the original survey population; diversity maximization particularly undersampled community configurations. Only selection of intentionally representative samples minimized differences in the selected sample set from the original microbial survey. An implementation is provided as the microPITA (Microbiomes: Picking Interesting Taxa for Analysis) software for two-stage study design of microbial communities.

  6. Two-stage eutectic metal brushes

    SciTech Connect

    Hsu, John S

    2009-07-14

    A two-stage eutectic metal brush assembly having a slip ring rigidly coupled to a shaft, the slip ring being electrically coupled to first voltage polarity. At least one brush is rigidly coupled to a second ring and slidingly engaged to the slip ring. Eutectic metal at least partially fills an annulus between the second ring and a stationary ring. At least one conductor is rigidly coupled to the stationary ring and electrically coupled to a second voltage polarity. Electrical continuity is maintained between the first voltage polarity and the second voltage polarity. Periodic rotational motion is present between the stationary ring and the second ring. Periodic rotational motion is also present between the brush and the slip ring.

  7. Two stage gear tooth dynamics program

    NASA Technical Reports Server (NTRS)

    Boyd, Linda S.

    1989-01-01

    The epicyclic gear dynamics program was expanded to add the option of evaluating the tooth pair dynamics for two epicyclic gear stages with peripheral components. This was a practical extension to the program as multiple gear stages are often used for speed reduction, space, weight, and/or auxiliary units. The option was developed for either stage to be a basic planetary, star, single external-external mesh, or single external-internal mesh. The two stage system allows for modeling of the peripherals with an input mass and shaft, an output mass and shaft, and a connecting shaft. Execution of the initial test case indicated an instability in the solution with the tooth paid loads growing to excessive magnitudes. A procedure to trace the instability is recommended as well as a method of reducing the program's computation time by reducing the number of boundary condition iterations.

  8. Classification in two-stage screening.

    PubMed

    Longford, Nicholas T

    2015-11-10

    Decision theory is applied to the problem of setting thresholds in medical screening when it is organised in two stages. In the first stage that involves a less expensive procedure that can be applied on a mass scale, an individual is classified as a negative or a likely positive. In the second stage, the likely positives are subjected to another test that classifies them as (definite) positives or negatives. The second-stage test is more accurate, but also more expensive and more involved, and so there are incentives to restrict its application. Robustness of the method with respect to the parameters, some of which have to be set by elicitation, is assessed by sensitivity analysis.

  9. Conceptual design of a two stage to orbit spacecraft

    NASA Technical Reports Server (NTRS)

    Armiger, Scott C.; Kwarta, Jennifer S.; Horsley, Kevin B.; Snow, Glenn A.; Koe, Eric C.; Single, Thomas G.

    1993-01-01

    This project, undertaken through the Advanced Space Design Program, developed a 'Conceptual Design of a Two Stage To Orbit Spacecraft (TSTO).' The design developed utilizes a combination of air breathing and rocket propulsion systems and is fully reusable, with horizontal takeoff and landing capability. The orbiter is carried in an aerodynamically designed bay in the aft section of the booster vehicle to the staging altitude. This TSTO Spacecraft design meets the requirements of replacing the aging Space Shuttle system with a more easily maintained vehicle with more flexible mission capability.

  10. Pyrosol process offers attractive two-stage liquefaction options

    SciTech Connect

    Not Available

    1986-09-01

    The Pyrosol process is a new two-stage process to convert coal into oil which comparatively consumes much less hydrogen and operates at considerably lower pressures. The PYROSOL process only partly liquefies the coal in the first stage using mild hydrogenation conditions. Approximately 25% of the daf coal is converted into distillates. The remaining residue, which contains a high amount of bitumen, is then coked in the second stage. In the hydrocoker the residue is cracked into additional oil and coke under a hydrogen atmosphere. The PYROSOL process can be configured for direct coal liquefaction or for coprocessing coal and oil. Only the liquefaction scheme is described in this paper.

  11. Modeling of a Sequential Two-Stage Combustor

    NASA Technical Reports Server (NTRS)

    Hendricks, R. C.; Liu, N.-S.; Gallagher, J. R.; Ryder, R. C.; Brankovic, A.; Hendricks, J. A.

    2005-01-01

    A sequential two-stage, natural gas fueled power generation combustion system is modeled to examine the fundamental aerodynamic and combustion characteristics of the system. The modeling methodology includes CAD-based geometry definition, and combustion computational fluid dynamics analysis. Graphical analysis is used to examine the complex vortical patterns in each component, identifying sources of pressure loss. The simulations demonstrate the importance of including the rotating high-pressure turbine blades in the computation, as this results in direct computation of combustion within the first turbine stage, and accurate simulation of the flow in the second combustion stage. The direct computation of hot-streaks through the rotating high-pressure turbine stage leads to improved understanding of the aerodynamic relationships between the primary and secondary combustors and the turbomachinery.

  12. Two-Stage Modelling Of Random Phenomena

    NASA Astrophysics Data System (ADS)

    Barańska, Anna

    2015-12-01

    The main objective of this publication was to present a two-stage algorithm of modelling random phenomena, based on multidimensional function modelling, on the example of modelling the real estate market for the purpose of real estate valuation and estimation of model parameters of foundations vertical displacements. The first stage of the presented algorithm includes a selection of a suitable form of the function model. In the classical algorithms, based on function modelling, prediction of the dependent variable is its value obtained directly from the model. The better the model reflects a relationship between the independent variables and their effect on the dependent variable, the more reliable is the model value. In this paper, an algorithm has been proposed which comprises adjustment of the value obtained from the model with a random correction determined from the residuals of the model for these cases which, in a separate analysis, were considered to be the most similar to the object for which we want to model the dependent variable. The effect of applying the developed quantitative procedures for calculating the corrections and qualitative methods to assess the similarity on the final outcome of the prediction and its accuracy, was examined by statistical methods, mainly using appropriate parametric tests of significance. The idea of the presented algorithm has been designed so as to approximate the value of the dependent variable of the studied phenomenon to its value in reality and, at the same time, to have it "smoothed out" by a well fitted modelling function.

  13. Repetitive, small-bore two-stage light gas gun

    SciTech Connect

    Combs, S.K.; Foust, C.R.; Fehling, D.T.; Gouge, M.J.; Milora, S.L.

    1991-01-01

    A repetitive two-stage light gas gun for high-speed pellet injection has been developed at Oak Ridge National Laboratory. In general, applications of the two-stage light gas gun have been limited to only single shots, with a finite time (at least minutes) needed for recovery and preparation for the next shot. The new device overcomes problems associated with repetitive operation, including rapidly evacuating the propellant gases, reloading the gun breech with a new projectile, returning the piston to its initial position, and refilling the first- and second-stage gas volumes to the appropriate pressure levels. In addition, some components are subjected to and must survive severe operating conditions, which include rapid cycling to high pressures and temperatures (up to thousands of bars and thousands of kelvins) and significant mechanical shocks. Small plastic projectiles (4-mm nominal size) and helium gas have been used in the prototype device, which was equipped with a 1-m-long pump tube and a 1-m-long gun barrel, to demonstrate repetitive operation (up to 1 Hz) at relatively high pellet velocities (up to 3000 m/s). The equipment is described, and experimental results are presented. 124 refs., 6 figs., 5 tabs.

  14. Two-stage chain sampling inspection plans with different sample sizes in the two stages

    NASA Technical Reports Server (NTRS)

    Stephens, K. S.; Dodge, H. F.

    1976-01-01

    A further generalization of the family of 'two-stage' chain sampling inspection plans is developed - viz, the use of different sample sizes in the two stages. Evaluation of the operating characteristics is accomplished by the Markov chain approach of the earlier work, modified to account for the different sample sizes. Markov chains for a number of plans are illustrated and several algebraic solutions are developed. Since these plans involve a variable amount of sampling, an evaluation of the average sampling number (ASN) is developed. A number of OC curves and ASN curves are presented. Some comparisons with plans having only one sample size are presented and indicate that improved discrimination is achieved by the two-sample-size plans.

  15. Advanced Diagnostics for High Pressure Spray Combustion.

    SciTech Connect

    Skeen, Scott A.; Manin, Julien Luc; Pickett, Lyle M.

    2014-06-01

    The development of accurate predictive engine simulations requires experimental data to both inform and validate the models, but very limited information is presently available about the chemical structure of high pressure spray flames under engine- relevant conditions. Probing such flames for chemical information using non- intrusive optical methods or intrusive sampling techniques, however, is challenging because of the physical and optical harshness of the environment. This work details two new diagnostics that have been developed and deployed to obtain quantitative species concentrations and soot volume fractions from a high-pressure combusting spray. A high-speed, high-pressure sampling system was developed to extract gaseous species (including soot precursor species) from within the flame for offline analysis by time-of-flight mass spectrometry. A high-speed multi-wavelength optical extinction diagnostic was also developed to quantify transient and quasi-steady soot processes. High-pressure sampling and offline characterization of gas-phase species formed following the pre-burn event was accomplished as well as characterization of gas-phase species present in the lift-off region of a high-pressure n-dodecane spray flame. For the initial samples discussed in this work several species were identified, including polycyclic aromatic hydrocarbons (PAH); however, quantitative mole fractions were not determined. Nevertheless, the diagnostic developed here does have this capability. Quantitative, time-resolved measurements of soot extinction were also accomplished and the novel use of multiple incident wavelengths proved valuable toward characterizing changes in soot optical properties within different regions of the spray flame.

  16. Residential oil burners with low input and two stages firing

    SciTech Connect

    Butcher, T.; Krajewski, R.; Leigh, R.

    1997-12-31

    The residential oil burner market is currently dominated by the pressure-atomized, retention head burner. At low firing rates pressure atomizing nozzles suffer rapid fouling of the small internal passages, leading to bad spray patterns and poor combustion performance. To overcome the low input limitations of conventional burners, a low pressure air-atomized burner has been developed watch can operate at fining rates as low as 0.25 gallons of oil per hour (10 kW). In addition, the burner can be operated in a high/low fining rate mode. Field tests with this burner have been conducted at a fixed input rate of 0.35 gph (14 kW) with a side-wall vented boiler/water storage tank combination. At the test home, instrumentation was installed to measure fuel and energy flows and record trends in system temperatures. Laboratory efficiency testing with water heaters and boilers has been completed using standard single purpose and combined appliance test procedures. The tests quantify benefits due to low firing rates and other burner features. A two stage oil burner gains a strong advantage in rated efficiency while maintaining capacity for high domestic hot water and space heating loads.

  17. Gas loading system for LANL two-stage gas guns

    NASA Astrophysics Data System (ADS)

    Gibson, Lee; Bartram, Brian; Dattelbaum, Dana; Lang, John; Morris, John

    2015-06-01

    A novel gas loading system was designed for the specific application of remotely loading high purity gases into targets for gas-gun driven plate impact experiments. The high purity gases are loaded into well-defined target configurations to obtain Hugoniot states in the gas phase at greater than ambient pressures. The small volume of the gas samples is challenging, as slight changing in the ambient temperature result in measurable pressure changes. Therefore, the ability to load a gas gun target and continually monitor the sample pressure prior to firing provides the most stable and reliable target fielding approach. We present the design and evaluation of a gas loading system built for the LANL 50 mm bore two-stage light gas gun. Targets for the gun are made of 6061 Al or OFHC Cu, and assembled to form a gas containment cell with a volume of approximately 1.38 cc. The compatibility of materials was a major consideration in the design of the system, particularly for its use with corrosive gases. Piping and valves are stainless steel with wetted seals made from Kalrez and Teflon. Preliminary testing was completed to ensure proper flow rate and that the proper safety controls were in place. The system has been used to successfully load Ar, Kr, Xe, and anhydrous ammonia with purities of up to 99.999 percent. The design of the system, and example data from the plate impact experiments will be shown. LA-UR-15-20521

  18. Design and test of a small two stage counter-rotating turbine for rocket engine application

    NASA Technical Reports Server (NTRS)

    Huber, F. W.; Branstrom, B. R.; Finke, A. K.; Johnson, P. D.; Rowey, R. J.; Veres, J. P.

    1993-01-01

    The aerodynamic design and rig test evaluation of a small counter-rotating turbine system is described. The technology represented by this turbine is being developed for application in an advanced upper stage rocket engine turbopump. This engine will employ an oxygen/hydrogen expander cycle and achieve high performance through efficient combustion, high combustion pressure, and high area ratio exhaust nozzle expansion. Engine performance goals require that the turbopump drive turbines achieve high efficiency at low gas flow rates. The low flow rates result in very small airfoil diameter, height and chord. The high efficiency and small size requirements present a challenging turbine design problem. The unconventional approach employed to meet this challenge is described, along with the detailed design process and resulting airfoil configurations. The method and results of full scale aerodynamic performance evaluation testing of both one and two stage configurations, as well as operation without the secondary stage stator are presented. The overall results of this effort illustrate that advanced aerodynamic design tools and hardware fabrication techniques have provided improved capability to produce small high performance turbines for advanced rocket engines.

  19. New LANL gas driven two-stage gun

    SciTech Connect

    Martinez, A.R.; Sheffied, S.A.; Whitehead, M.C.; Olivas, H.D.; Dick, J.J. )

    1994-07-10

    A new compressed-helium driven two-stage light gas gun has been installed at LANL to study shock initiated reaction in insensitive high explosives. The gun (based on a design at Ernst Mach Institute) has a 100-mm diameter by 7.6 long pump tube and a 50-mm diameter by 7.6-m long launch tube. The gas breech, capable of pressures up to 15,000 psi, has a volume of 42.5 liters and can be used in either a wrap-around or double-diaphragm mode. This breech was designed so we could use helium rather than powder combustion gases to drive the pump piston, eliminating the safety and cleanup problems assoicated with gun powder. Large hydraulic clamps (pressurized to 10,000 psi) are used to clamp the breech to the pump tube, the pump tube to the transition section, and the transition section to the launch tube. The target chamber was designed to allow the necessary room to do multiple magnetic gauging experiments. Gun control is accomplished using a MAC computer and LabVIEW control software. [copyright]American Institute of Physics

  20. New LANL gas-driven two-stage gun

    SciTech Connect

    Martinez, A.R.; Sheffield, S.A.; Whitehead, M.C.; Olivas, H.D.; Dick, J.J.

    1993-08-01

    A new compressed-helium driven two-stage light gas gun has been installed at LANL to study shock initiated reaction in insensitive high explosives. The gun (based on a design at Ernst Mach Institute) has a 100-mm diameter by 7.6 long pump tube and a 50-mm diameter by 7.6-m long launch tube. The gas breech, capable of pressures up to 15.000 psi, has a volume of 42.5 liters and can be used in either a wrap-around or double-diaphragm mode. This breech was designed so we could use helium rather than powder combustion gases to drive the pump piston, eliminating the safety and cleanup problems associated with gun powder. Large hydraulic clamps (pressurized to 10,000 psi) are used to clamp the breech to the pump tube, the pump tube to the transition section, and the transition section to the launch tube. The target chamber was designed to allow the necessary room to do multiple magnetic gauging experiments. Gun control is accomplished using a MAC computer and LabVIEW control software.

  1. New LANL gas driven two-stage gun

    NASA Astrophysics Data System (ADS)

    Martinez, A. R.; Sheffied, S. A.; Whitehead, M. C.; Olivas, H. D.; Dick, J. J.

    1994-07-01

    A new compressed-helium driven two-stage light gas gun has been installed at LANL to study shock initiated reaction in insensitive high explosives. The gun (based on a design at Ernst Mach Institute) has a 100-mm diameter by 7.6 long pump tube and a 50-mm diameter by 7.6-m long launch tube. The gas breech, capable of pressures up to 15,000 psi, has a volume of 42.5 liters and can be used in either a wrap-around or double-diaphragm mode. This breech was designed so we could use helium rather than powder combustion gases to drive the pump piston, eliminating the safety and cleanup problems assoicated with gun powder. Large hydraulic clamps (pressurized to 10,000 psi) are used to clamp the breech to the pump tube, the pump tube to the transition section, and the transition section to the launch tube. The target chamber was designed to allow the necessary room to do multiple magnetic gauging experiments. Gun control is accomplished using a MAC computer and LabVIEW control software.

  2. Cylinder Pressure-Based Spark Advance Control for SI Engines

    NASA Astrophysics Data System (ADS)

    Park, Seungbum; Yoon, Paljoo; Sunwoo, Myoungho

    The introduction of inexpensive cylinder pressure sensors provides new opportunities for precise engine control. This paper presents a spark advance control strategy based upon cylinder pressure in spark ignition engines. It is well known that the location of peak pressure(LPP) reflects combustion phasing and can be used for controlling the spark advance. The well-known problems of the LPP-based spark advance control method are that many samples of data are required and there is loss of combustion phasing detection capability due to hook-back at late burn conditions. To solve these problems, a multi-layer feedforward neural network is employed. The LPP and hook-back are estimated, using the neural network, which needs only five output voltage samples from the pressure sensor. The neural network plays an important role in mitigating the A/D conversion load of an electronic engine controller by increasing the sampling interval from 1° crank angle (CA) to 20° CA. A proposed control algorithm does not need a sensor calibration and pegging (bias calculation) procedure because the neural network estimates the LPP from the raw sensor output voltage. The estimated LPP can be regarded as a good index for combustion phasing, and can also be used as an MBT control parameter. The feasibility of this methodology is closely examined through steady and transient engine operations to control individual cylinder spark advances. The experimental results have revealed a favorable agreement of optimal combustion phasing in each cylinder.

  3. Advanced High Pressure O2/H2 Technology

    NASA Technical Reports Server (NTRS)

    Morea, S. F. (Editor); Wu, S. T. (Editor)

    1985-01-01

    Activities in the development of advanced high pressure oxygen-hydrogen stage combustion rocket engines are reported. Particular emphasis is given to the Space Shuttle main engine. The areas of engine technology discussed include fracture and fatigue in engine components, manufacturing and producibility engineering, materials, bearing technology, structure dynamics, fluid dynamics, and instrumentation technology.

  4. Catalytic two-stage coal hydrogenation and hydroconversion process

    DOEpatents

    MacArthur, James B.; McLean, Joseph B.; Comolli, Alfred G.

    1989-01-01

    A process for two-stage catalytic hydrogenation and liquefaction of coal to produce increased yields of low-boiling hydrocarbon liquid and gas products. In the process, the particulate coal is slurried with a process-derived liquid solvent and fed at temperature below about 650.degree. F. into a first stage catalytic reaction zone operated at conditions which promote controlled rate liquefaction of the coal, while simultaneously hydrogenating the hydrocarbon recycle oils at conditions favoring hydrogenation reactions. The first stage reactor is maintained at 650.degree.-800.degree. F. temperature, 1000-4000 psig hydrogen partial pressure, and 10-60 lb coal/hr/ft.sup.3 reactor space velocity. The partially hydrogenated material from the first stage reaction zone is passed directly to the close-coupled second stage catalytic reaction zone maintained at a temperature at least about 25.degree. F. higher than for the first stage reactor and within a range of 750.degree.-875.degree. F. temperature for further hydrogenation and thermal hydroconversion reactions. By this process, the coal feed is successively catalytically hydrogenated and hydroconverted at selected conditions, which results in significantly increased yields of desirable low-boiling hydrocarbon liquid products and minimal production of undesirable residuum and unconverted coal and hydrocarbon gases, with use of less energy to obtain the low molecular weight products, while catalyst life is substantially increased.

  5. Two-stage, hydraulic-assisted fuel injection nozzle

    SciTech Connect

    Cotter, D.H.; Teerman, R.F.; Timmer, R.C.

    1987-08-04

    This patent describes a fuel injection nozzle for internal combustion engines including, in combination, a nozzle body means having a fuel inlet means at one end and a fuel injection spray orifice means at its opposite spray outlet end with a discharge passage means interconnecting the inlet means to the spray orifice means; a valve seat in the passage means upstream of the spray orifice means, a spring chamber means in the nozzle body means intermediate the ends, a pressure actuated injection valve in the nozzle body movable relative to the valve seat and having one end extending into the spring chamber means; a first spring means and second spring means in the spring chamber means operatively connected to each other and to the injection valve to effect the opening of the injection valve in two stages is controlled by the first spring means; and the second spring means with a first stage opening as controlled by the first spring and a second state opening as controlled by both the first and second spring. A valve controlled orifice passage means is in flow communication at one end with the discharge passage means and at its opposite end with the spring chamber means.

  6. Effect of Silica Fume on two-stage Concrete Strength

    NASA Astrophysics Data System (ADS)

    Abdelgader, H. S.; El-Baden, A. S.

    2015-11-01

    Two-stage concrete (TSC) is an innovative concrete that does not require vibration for placing and compaction. TSC is a simple concept; it is made using the same basic constituents as traditional concrete: cement, coarse aggregate, sand and water as well as mineral and chemical admixtures. As its name suggests, it is produced through a two-stage process. Firstly washed coarse aggregate is placed into the formwork in-situ. Later a specifically designed self compacting grout is introduced into the form from the lowest point under gravity pressure to fill the voids, cementing the aggregate into a monolith. The hardened concrete is dense, homogeneous and has in general improved engineering properties and durability. This paper presents the results from a research work attempt to study the effect of silica fume (SF) and superplasticizers admixtures (SP) on compressive and tensile strength of TSC using various combinations of water to cement ratio (w/c) and cement to sand ratio (c/s). Thirty six concrete mixes with different grout constituents were tested. From each mix twenty four standard cylinder samples of size (150mm×300mm) of concrete containing crushed aggregate were produced. The tested samples were made from combinations of w/c equal to: 0.45, 0.55 and 0.85, and three c/s of values: 0.5, 1 and 1.5. Silica fume was added at a dosage of 6% of weight of cement, while superplasticizer was added at a dosage of 2% of cement weight. Results indicated that both tensile and compressive strength of TSC can be statistically derived as a function of w/c and c/s with good correlation coefficients. The basic principle of traditional concrete, which says that an increase in water/cement ratio will lead to a reduction in compressive strength, was shown to hold true for TSC specimens tested. Using a combination of both silica fume and superplasticisers caused a significant increase in strength relative to control mixes.

  7. A two-stage model for Cepaea polymorphism

    PubMed Central

    Cook, L. M.

    1998-01-01

    The history of the study of snails in the genus Cepaea is briefly outlined. Cepaea nemoralis and C. hortensis are polymorphic for genetically controlled shell colour and banding, which has been the main interest of the work covered. Random drift, selective predation and climatic selection, both at a macro- and micro-scale, all affect gene frequency. The usual approach to understanding maintenance of the polymorphism, has been to look for centripetal effects on frequency. Possible processes include balance of mutation pressure and drift, heterozygote advantage, relational balance heterosis, frequency-dependent predation, multi-niche selective balance, or some combination of these. Mutational balance is overlaid by more substantial forces. There is some evidence for heterosis. Predation by birds may protect the polymorphism, and act apostatically to favour distinct morphs. Although not substantiated for Cepaea, many studies show that predators behave in the appropriate manner, while shell colour polymorphisms in molluscs occur most commonly in species exposed to visually searching predators. It is not known whether different thermal properties of the shells help to generate equilibria. Migration between colonies is probably greater than originally thought. The present geographical range has been occupied for less than 5000 generations. Climatic and human modification alter snail habitats relatively rapidly, which in turn changes selection pressures. A simple simulation shows that migration coupled with selection which fluctuates but is not centripetal, may retain polymorphism for sufficiently long to account for the patterns we see today. There may therefore be a two-stage basis to the polymorphism, comprising long-term but weak balancing forces coupled with fluctuating selection which does not necessarily balance but results in very slow elimination. Persistence of genetic variants in this way may provide the conditions for evolution of a balanced genome.

  8. Recent Advances in High Pressure and Temperature Rheological Studies

    SciTech Connect

    Wang, Yanbin; Hilairet, Nadege; Dera, Przemyslaw

    2012-01-20

    Rheological studies at high pressure and temperature using in-situ X-ray diffraction and imaging have made significant progresses in recent years, thanks to a combination of recent developments in several areas: (1) advances in synchrotron X-ray techniques, (2) advances in deformation devices and the abilities to control pressure, temperature, stress, strain and strain rates, (3) theoretical and computational advances in stress determination based on powder and single crystal diffraction, (4) theoretical and computational advances in modeling of grain-level micromechanics based on elasto-plastic and visco-plastic self-consistent formulations. In this article, we briefly introduce the experimental techniques and theoretical background for in-situ high pressure, high temperature rheological studies, and then review recent studies of rheological properties of major mantle materials. Some currently encountered issues have prompted developments in single-crystal quasi-Laue diffraction for complete stress tensor determination and textural evolution of poly-phased composites based on X-ray microtomography. Future prospects are discussed.

  9. Advanced pressurized water reactor for improved resource utilization, part II - composite advanced PWR concept

    SciTech Connect

    Turner, S.E.; Gurley, M.K.; Kirby, K.D.; Mitchell, W III

    1981-09-15

    This report evaluates the enhanced resource utilization in an advanced pressurized water reactor (PWR) concept using a composite of selected improvements identified in a companion study. The selected improvements were in the areas of reduced loss of neutrons to control poisons, reduced loss of neutrons in leakage from the core, and improved blanket/reflector concepts. These improvements were incorporated into a single composite advanced PWR. A preliminary assessment of resource requirements and costs and impact on safety are presented.

  10. A simulation study of the behavior of a two-stage turbocharging system during surge

    SciTech Connect

    Cheese, P.; Hetet, J.F.; Tauzia, X.; Roy, P.; Inozu, B.

    1996-12-31

    Turbocharger matching for a high rated two-stage turbocharged Diesel engine is rather difficult due to the power balance between the two turbocharger stages. Compressor surge is a predominant factor, especially for naval applications for which operation ranges are quite wide. In this paper, a simulation study of a two-stage turbocharged system that includes a low pressure and a high pressure compressor is presented. Equations that are specific to such a system are added to a basic model and the resulting set of equations is solved using ACSL. The influence of the geometry of the charging air system on the compressor surge is analyzed according to the primary engine parameters (cylinder pressure, engine speed and distribution diagram)

  11. Structure design of and experimental research on a two-stage laval foam breaker for foam fluid recycling.

    PubMed

    Wang, Jin-song; Cao, Pin-lu; Yin, Kun

    2015-07-01

    Environmental, economical and efficient antifoaming technology is the basis for achievement of foam drilling fluid recycling. The present study designed a novel two-stage laval mechanical foam breaker that primarily uses vacuum generated by Coanda effect and Laval principle to break foam. Numerical simulation results showed that the value and distribution of negative pressure of two-stage laval foam breaker were larger than that of the normal foam breaker. Experimental results showed that foam-breaking efficiency of two-stage laval foam breaker was higher than that of normal foam breaker, when gas-to-liquid ratio and liquid flow rate changed. The foam-breaking efficiency of normal foam breaker decreased rapidly with increasing foam stability, whereas the two-stage laval foam breaker remained unchanged. Foam base fluid would be recycled using two-stage laval foam breaker, which would reduce the foam drilling cost sharply and waste disposals that adverse by affect the environment. PMID:26387358

  12. Structure design of and experimental research on a two-stage laval foam breaker for foam fluid recycling.

    PubMed

    Wang, Jin-song; Cao, Pin-lu; Yin, Kun

    2015-07-01

    Environmental, economical and efficient antifoaming technology is the basis for achievement of foam drilling fluid recycling. The present study designed a novel two-stage laval mechanical foam breaker that primarily uses vacuum generated by Coanda effect and Laval principle to break foam. Numerical simulation results showed that the value and distribution of negative pressure of two-stage laval foam breaker were larger than that of the normal foam breaker. Experimental results showed that foam-breaking efficiency of two-stage laval foam breaker was higher than that of normal foam breaker, when gas-to-liquid ratio and liquid flow rate changed. The foam-breaking efficiency of normal foam breaker decreased rapidly with increasing foam stability, whereas the two-stage laval foam breaker remained unchanged. Foam base fluid would be recycled using two-stage laval foam breaker, which would reduce the foam drilling cost sharply and waste disposals that adverse by affect the environment.

  13. Optimisation of two-stage screw expanders for waste heat recovery applications

    NASA Astrophysics Data System (ADS)

    Read, M. G.; Smith, I. K.; Stosic, N.

    2015-08-01

    It has previously been shown that the use of two-phase screw expanders in power generation cycles can achieve an increase in the utilisation of available energy from a low temperature heat source when compared with more conventional single-phase turbines. However, screw expander efficiencies are more sensitive to expansion volume ratio than turbines, and this increases as the expander inlet vapour dryness fraction decreases. For singlestage screw machines with low inlet dryness, this can lead to under expansion of the working fluid and low isentropic efficiency for the expansion process. The performance of the cycle can potentially be improved by using a two-stage expander, consisting of a low pressure machine and a smaller high pressure machine connected in series. By expanding the working fluid over two stages, the built-in volume ratios of the two machines can be selected to provide a better match with the overall expansion process, thereby increasing efficiency for particular inlet and discharge conditions. The mass flow rate though both stages must however be matched, and the compromise between increasing efficiency and maximising power output must also be considered. This research uses a rigorous thermodynamic screw machine model to compare the performance of single and two-stage expanders over a range of operating conditions. The model allows optimisation of the required intermediate pressure in the two- stage expander, along with the rotational speed and built-in volume ratio of both screw machine stages. The results allow the two-stage machine to be fully specified in order to achieve maximum efficiency for a required power output.

  14. Two-stage thermal/nonthermal waste treatment process

    SciTech Connect

    Rosocha, L.A.; Anderson, G.K.; Coogan, J.J.; Kang, M.; Tennant, R.A.; Wantuck, P.J.

    1993-05-01

    An innovative waste treatment technology is being developed in Los Alamos to address the destruction of hazardous organic wastes. The technology described in this report uses two stages: a packed bed reactor (PBR) in the first stage to volatilize and/or combust liquid organics and a silent discharge plasma (SDP) reactor to remove entrained hazardous compounds in the off-gas to even lower levels. We have constructed pre-pilot-scale PBR-SDP apparatus and tested the two stages separately and in combined modes. These tests are described in the report.

  15. STARS A Two Stage High Gain Harmonic Generation FEL Demonstrator

    SciTech Connect

    M. Abo-Bakr; W. Anders; J. Bahrdt; P. Budz; K.B. Buerkmann-Gehrlein; O. Dressler; H.A. Duerr; V. Duerr; W. Eberhardt; S. Eisebitt; J. Feikes; R. Follath; A. Gaupp; R. Goergen; K. Goldammer; S.C. Hessler; K. Holldack; E. Jaeschke; Thorsten Kamps; S. Klauke; J. Knobloch; O. Kugeler; B.C. Kuske; P. Kuske; A. Meseck; R. Mitzner; R. Mueller; M. Neeb; A. Neumann; K. Ott; D. Pfluckhahn; T. Quast; M. Scheer; Th. Schroeter; M. Schuster; F. Senf; G. Wuestefeld; D. Kramer; Frank Marhauser

    2007-08-01

    BESSY is proposing a demonstration facility, called STARS, for a two-stage high-gain harmonic generation free electron laser (HGHG FEL). STARS is planned for lasing in the wavelength range 40 to 70 nm, requiring a beam energy of 325 MeV. The facility consists of a normal conducting gun, three superconducting TESLA-type acceleration modules modified for CW operation, a single stage bunch compressor and finally a two-stage HGHG cascaded FEL. This paper describes the faciliy layout and the rationale behind the operation parameters.

  16. Two stage pulse tube cooler for space applications.

    SciTech Connect

    Pietrzak, T.; Toma, G.; Orsini, R.; Nguyen, T.; Tward, E.

    2003-09-01

    This paper presents the development of a two-stage pulse tube cooler for space applications. The staged cooler incorporates an integral High Efficiency Cryocooler (HEC) pulse tube cooler with a linear cold head and a split second remote coaxial cold head. The two-stage cold head was designed to provide simultaneous large cooling power at 95 K at the linear cold head and 180 K at the split coaxial cold head. The innovative staging design allows up to 50 cm of separation between the cold heads. The cooler is compatible with the existing HEC flight electronics.

  17. Advanced fuels for plutonium management in pressurized water reactors

    NASA Astrophysics Data System (ADS)

    Vasile, A.; Dufour, Ph; Golfier, H.; Grouiller, J. P.; Guillet, J. L.; Poinot, Ch; Youinou, G.; Zaetta, A.

    2003-06-01

    Several fuel concepts are under investigation at CEA with the aim of manage plutonium inventories in pressurized water reactors. This options range from the use of mature technologies like MOX adapted in the case of MOX-EUS (enriched uranium support) and COmbustible Recyclage A ILot (CORAIL) assemblies to more innovative technologies using IMF like DUPLEX and advanced plutonium assembly (APA). The plutonium burning performances reported to the electrical production go from 7 to 60 kg (TW h) -1. More detailed analysis covering economic, sustainability, reliability and safety aspects and their integration in the whole fuel cycle would allow identifying the best candidate.

  18. Square Kilometre Array Station Configuration Using Two-Stage Beamforming

    NASA Astrophysics Data System (ADS)

    Jiwani, Aziz; Colegate, Tim; Razavi-Ghods, Nima; Hall, Peter J.; Padhi, Shantanu; bij de Vaate, Jan Geralt

    2013-03-01

    The lowest frequency band (70-450 MHz) of the Square Kilometre Array (SKA) will consist of sparse aperture arrays grouped into geographically localised patches or stations. Signals from thousands of antennas in each station will be beamformed to produce station beams which form the inputs for the central correlator. Two-stage beamforming within stations can reduce SKA-low signal processing load and costs, but has not been previously explored for the irregular station layouts now favoured in radio astronomy arrays. This paper illustrates the effects of two-stage beamforming on sidelobes and effective area, for two representative station layouts (regular and irregular gridded tiles on an irregular station). The performance is compared with a single-stage, irregular station. The inner sidelobe levels do not change significantly between layouts, but the more distant sidelobes are affected by the tile layouts; regular tile creates diffuse, but regular, grating lobes. With very sparse arrays, the station effective area is similar between layouts. At lower frequencies, the regular tile significantly reduces effective area, hence sensitivity. The effective area is highest for a two-stage irregular station, but it requires a larger station extent than the other two layouts. Although there are cost benefits for stations with two-stage beamforming, we conclude that more accurate station modelling and SKA-low configuration specifications are required before design finalisation.

  19. Pressure-Sensitive Paints Advance Rotorcraft Design Testing

    NASA Technical Reports Server (NTRS)

    2013-01-01

    The rotors of certain helicopters can spin at speeds as high as 500 revolutions per minute. As the blades slice through the air, they flex, moving into the wind and back out, experiencing pressure changes on the order of thousands of times a second and even higher. All of this makes acquiring a true understanding of rotorcraft aerodynamics a difficult task. A traditional means of acquiring aerodynamic data is to conduct wind tunnel tests using a vehicle model outfitted with pressure taps and other sensors. These sensors add significant costs to wind tunnel testing while only providing measurements at discrete locations on the model's surface. In addition, standard sensor solutions do not work for pulling data from a rotor in motion. "Typical static pressure instrumentation can't handle that," explains Neal Watkins, electronics engineer in Langley Research Center s Advanced Sensing and Optical Measurement Branch. "There are dynamic pressure taps, but your costs go up by a factor of five to ten if you use those. In addition, recovery of the pressure tap readings is accomplished through slip rings, which allow only a limited amount of sensors and can require significant maintenance throughout a typical rotor test." One alternative to sensor-based wind tunnel testing is pressure sensitive paint (PSP). A coating of a specialized paint containing luminescent material is applied to the model. When exposed to an LED or laser light source, the material glows. The glowing material tends to be reactive to oxygen, explains Watkins, which causes the glow to diminish. The more oxygen that is present (or the more air present, since oxygen exists in a fixed proportion in air), the less the painted surface glows. Imaged with a camera, the areas experiencing greater air pressure show up darker than areas of less pressure. "The paint allows for a global pressure map as opposed to specific points," says Watkins. With PSP, each pixel recorded by the camera becomes an optical pressure

  20. Changes to the LANL gas-driven two-stage gun: Magnetic gauge instrumentation, etc.

    SciTech Connect

    Sheffield, S.A.; Gustavsen, R.L.; Martinez, A.R.; Alcon, R.R.

    1996-12-31

    Our gas-driven two-stage gun was designed and built to do initiation studies on insensitive high explosives as well as other equation of state experiments on inert materials. Our preferred method of measuring initiation phenomena involves the use of magnetic particle velocity gauges. In order to accommodate this type of gauging in our two-stage gun, projectile velocity was sacrificed in favor of a larger experimental target area (obtained by using a 50 mm diameter launch tube). We have used magnetic gauging on our 72-mm bore diameter single-stage gun for over 15 years and it has proven a very effective technique to monitor reactive shock wave evolution. This technique has now been adapted to our gas-driven two-stage gun. We describe the method used, as well as some of the difficulties that arose while installing this technique. Several magnetic gauge experiments have been completed on plastic materials. Waveforms obtained in one experiment are given, along with the Hugoniot information that was obtained. This new technique is now working quite well, as is evidenced by the data. To our knowledge, this is the first time magnetic gauging has been used on a two-stage gun. We have also made changes to the burst diaphragm package in the transition section to ensure that the petals do not break off during the opening process and to increase the burst pressure. This will also be discussed briefly.

  1. Advanced Extra-Vehicular Activity Pressure Garment Requirements Development

    NASA Technical Reports Server (NTRS)

    Ross, Amy; Aitchison, Lindsay; Rhodes, Richard

    2015-01-01

    The NASA Johnson Space Center advanced pressure garment technology development team is addressing requirements development for exploration missions. Lessons learned from the Z-2 high fidelity prototype development have reiterated that clear low-level requirements and verification methods reduce risk to the government, improve efficiency in pressure garment design efforts, and enable the government to be a smart buyer. The expectation is to provide requirements at the specification level that are validated so that their impact on pressure garment design is understood. Additionally, the team will provide defined verification protocols for the requirements. However, in reviewing exploration space suit high level requirements there are several gaps in the team's ability to define and verify related lower level requirements. This paper addresses the efforts in requirement areas such as mobility/fit/comfort and environmental protection (dust, radiation, plasma, secondary impacts) to determine the method by which the requirements can be defined and use of those methods for verification. Gaps exist at various stages. In some cases component level work is underway, but no system level effort has begun; in other cases no effort has been initiated to close the gap. Status of on-going efforts and potential approaches to open gaps are discussed.

  2. Some relations between two stages DNA splicing languages

    NASA Astrophysics Data System (ADS)

    Mudaber, Mohammad Hassan; Yusof, Yuhani; Mohamad, Mohd Sham

    2014-06-01

    A new symbolization of Yusof-Goode (Y-G) rule, which is associated with Y-G splicing system, was introduced by Yusof in 2012 under the framework of formal language theory. The purpose of this investigation is to present the biological process of DNA splicing in a translucent way. In this study, two stages splicing languages are introduced based on Y-G approach and some relations between stage one and stage two splicing languages are presented, given as theorems. Additionally, the existing relations between two stages splicing languages based on crossings and contexts of restriction enzymes factors with respect to two initial strings (having two cutting sites) and two rules are presented as subset.

  3. Two-stage upflow anaerobic digestion of concentrated sludge

    SciTech Connect

    Ghosh, S.; Sajjad, A.; Henry, M.P.; Bleakney, R.A.

    1983-01-01

    The development of an innovative fermentation mode, two-stage digestion, and the application of a novel upflow reactor design to permit biogasification of high-solids-content wastewater sludges at higher loading rates and lower-than-normal hydraulic residence times (HRT) to obtain higher gas and methane yields and production rates and better effluent qualities than those achieved with conventional single-stage continuously stirred tank reactor (CSTR) digesters are presented. A bench-scale two-stage upflow system operated with primary sludge at a 5.6-day HRT (1.2 days for Stage 1 and 4.4 days for Stage 2) exhibited a methane yield of 6.8 SCF/lb VS added, which was about 350% higher than that from conventional digestion at the same HRT.

  4. Two-Stage Variable Sample-Rate Conversion System

    NASA Technical Reports Server (NTRS)

    Tkacenko, Andre

    2009-01-01

    A two-stage variable sample-rate conversion (SRC) system has been pro posed as part of a digital signal-processing system in a digital com munication radio receiver that utilizes a variety of data rates. The proposed system would be used as an interface between (1) an analog- todigital converter used in the front end of the receiver to sample an intermediatefrequency signal at a fixed input rate and (2) digita lly implemented tracking loops in subsequent stages that operate at v arious sample rates that are generally lower than the input sample r ate. This Two-Stage System would be capable of converting from an input sample rate to a desired lower output sample rate that could be var iable and not necessarily a rational fraction of the input rate.

  5. Two-stage SBR for treatment of oil refinery wastewater.

    PubMed

    Lee, L Y; Hu, J Y; Ong, S L; Ng, W J; Ren, J H; Wong, S H

    2004-01-01

    A two-stage sequencing batch reactor (SBR) system was used for treatment of oily wastewater with COD and oil and grease (O&G) concentrations ranging from 1,722-7,826 mg/L and 5,365-13,350 mg/L, respectively. A suitable start-up protocol was developed using gradual increase in oily wastewater composition with methanol as the co-substrate. This strategy enabled a short acclimation period of 12 days for the sludge in the two-stage SBR to adapt to the oily wastewater. After acclimation, the 1st stage and 2nd stage SBRs were able to achieve COD removals of 47.0+/-2.4% and 95.3+/-0.5%, respectively. The 1st stage SBR was able to achieve 99.8+/-0.1% of O&G removal and effluent O&G from the 1st stage SBR was only 6+/-2 mg/L. The 2nd stage SBR was used to further remove COD in the effluent from the 1st stage SBR. The final effluent from the 2nd stage SBR had a COD concentration of 97+/-16 mg/L with no detectable O&G content. Thus, a two-stage SBR system was shown to be feasible for treating high strength oily wastewater to meet the local discharge standards.

  6. Two-Stage Bayesian Model Averaging in Endogenous Variable Models.

    PubMed

    Lenkoski, Alex; Eicher, Theo S; Raftery, Adrian E

    2014-01-01

    Economic modeling in the presence of endogeneity is subject to model uncertainty at both the instrument and covariate level. We propose a Two-Stage Bayesian Model Averaging (2SBMA) methodology that extends the Two-Stage Least Squares (2SLS) estimator. By constructing a Two-Stage Unit Information Prior in the endogenous variable model, we are able to efficiently combine established methods for addressing model uncertainty in regression models with the classic technique of 2SLS. To assess the validity of instruments in the 2SBMA context, we develop Bayesian tests of the identification restriction that are based on model averaged posterior predictive p-values. A simulation study showed that 2SBMA has the ability to recover structure in both the instrument and covariate set, and substantially improves the sharpness of resulting coefficient estimates in comparison to 2SLS using the full specification in an automatic fashion. Due to the increased parsimony of the 2SBMA estimate, the Bayesian Sargan test had a power of 50 percent in detecting a violation of the exogeneity assumption, while the method based on 2SLS using the full specification had negligible power. We apply our approach to the problem of development accounting, and find support not only for institutions, but also for geography and integration as development determinants, once both model uncertainty and endogeneity have been jointly addressed.

  7. The design of two-stage-to-orbit vehicles

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Two separate student design groups developed conceptual designs for a two-stage-to-orbit vehicle, with each design group consisting of a carrier team and an orbiter team. A two-stage-to-orbit system is considered in the event that single-stage-to-orbit is deemed not feasible in the foreseeable future; the two-stage system would also be used as a complement to an already existing heavy lift vehicle. The design specifications given are to lift a 10,000-lb payload 27 ft long by 10 ft diameter, to low Earth orbit (300 n.m.) using an air breathing carrier configuration that will take off horizontally within 15,000 ft. The staging Mach number and altitude were to be determined by the design groups. One group designed a delta wing/body carrier with the orbiter nested within the fuselage of the carrier, and the other group produced a blended cranked-delta wing/body carrier with the orbiter in the more conventional piggyback configuration. Each carrier used liquid hydrogen-fueled turbofanramjet engines, with data provided by General Electric Aircraft Engine Group. While one orbiter used a full-scale Space Shuttle Main Engine (SSME), the other orbiter employed a half-scale SSME coupled with scramjet engines, with data again provided by General Electric. The two groups conceptual designs, along with the technical trade-offs, difficulties, and details that surfaced during the design process are presented.

  8. Two-Stage Bayesian Model Averaging in Endogenous Variable Models.

    PubMed

    Lenkoski, Alex; Eicher, Theo S; Raftery, Adrian E

    2014-01-01

    Economic modeling in the presence of endogeneity is subject to model uncertainty at both the instrument and covariate level. We propose a Two-Stage Bayesian Model Averaging (2SBMA) methodology that extends the Two-Stage Least Squares (2SLS) estimator. By constructing a Two-Stage Unit Information Prior in the endogenous variable model, we are able to efficiently combine established methods for addressing model uncertainty in regression models with the classic technique of 2SLS. To assess the validity of instruments in the 2SBMA context, we develop Bayesian tests of the identification restriction that are based on model averaged posterior predictive p-values. A simulation study showed that 2SBMA has the ability to recover structure in both the instrument and covariate set, and substantially improves the sharpness of resulting coefficient estimates in comparison to 2SLS using the full specification in an automatic fashion. Due to the increased parsimony of the 2SBMA estimate, the Bayesian Sargan test had a power of 50 percent in detecting a violation of the exogeneity assumption, while the method based on 2SLS using the full specification had negligible power. We apply our approach to the problem of development accounting, and find support not only for institutions, but also for geography and integration as development determinants, once both model uncertainty and endogeneity have been jointly addressed. PMID:24223471

  9. Two-Stage Machine Learning model for guideline development.

    PubMed

    Mani, S; Shankle, W R; Dick, M B; Pazzani, M J

    1999-05-01

    We present a Two-Stage Machine Learning (ML) model as a data mining method to develop practice guidelines and apply it to the problem of dementia staging. Dementia staging in clinical settings is at present complex and highly subjective because of the ambiguities and the complicated nature of existing guidelines. Our model abstracts the two-stage process used by physicians to arrive at the global Clinical Dementia Rating Scale (CDRS) score. The model incorporates learning intermediate concepts (CDRS category scores) in the first stage that then become the feature space for the second stage (global CDRS score). The sample consisted of 678 patients evaluated in the Alzheimer's Disease Research Center at the University of California, Irvine. The demographic variables, functional and cognitive test results used by physicians for the task of dementia severity staging were used as input to the machine learning algorithms. Decision tree learners and rule inducers (C4.5, Cart, C4.5 rules) were selected for our study as they give expressive models, and Naive Bayes was used as a baseline algorithm for comparison purposes. We first learned the six CDRS category scores (memory, orientation, judgement and problem solving, personal care, home and hobbies, and community affairs). These learned CDRS category scores were then used to learn the global CDRS scores. The Two-Stage ML model classified as well as or better than the published inter-rater agreements for both the category and global CDRS scoring by dementia experts. Furthermore, for the most critical distinction, normal versus very mildly impaired, the Two-Stage ML model was 28.1 and 6.6% more accurate than published performances by domain experts. Our study of the CDRS examined one of the largest, most diverse samples in the literature, suggesting that our findings are robust. The Two-Stage ML model also identified a CDRS category, Judgment and Problem Solving, which has low classification accuracy similar to published

  10. Forty-five-degree two-stage venous cannula: advantages over standard two-stage venous cannulation.

    PubMed

    Lawrence, D R; Desai, J B

    1997-01-01

    We present a 45-degree two-stage venous cannula that confers advantage to the surgeon using cardiopulmonary bypass. This cannula exits the mediastinum under the transverse bar of the sternal retractor, leaving the rostral end of the sternal incision free of apparatus. It allows for lifting of the heart with minimal effect on venous return and does not interfere with the radially laid out sutures of an aortic valve replacement using an interrupted suture technique.

  11. High-pressure propulsion - advanced concepts for cooling

    NASA Astrophysics Data System (ADS)

    Schoerman, Leonard

    The state-of-the-art liquid propellant cooled combustion chambers utilized in the space shuttle are third-generation designs which have evolved from a continuing demand for higher operating pressure and aircraft-type reusability. History has shown that major advances in cooling occur in approximately ten-year cycles, with each cycle providing a nominal 400% increase in operating pressure and/or a higher degree of reusability. The previous technologies include the first-generation double-wall steel jackets used in the 220 psi V-2 and Aerobee, and the second generation wire-wrapped double tapered tubular assemblies typical of the 800 psi Titan I, II, and III, and 1000 psi F-1 engines. The third-generation designs utilize milled slot, high thermal conductivity liners and electrodeposited nickel closures. The space shuttle main engine operating at 3200 psia is adequate for individual flights; however, the desired goal of 55 service-free missions has yet to be realized. Future single-stage-to-orbit propulsion concepts can benefit from a further increase in operating pressures to 6000 to 10,000 psi combined with engine reuse capabilities in excess of the 55 flight goals of the space shuttle. A fourth-generation approach will be required to attain these more ambitious goals. These new designs will require a combination of cooling processes, including regenerative and transpiration, combined with improved high-temperature materials and new fabrication techniques. The limitations of the third-generation designs, the impact of propellant/coolant selection, and the approaches for the coming fourth-generation cooling technologies are discussed.

  12. Discussion on back-to-back two-stage centrifugal compressor compact design techniques

    NASA Astrophysics Data System (ADS)

    Huo, Lei; Liu, Huoxing

    2013-12-01

    Design a small flow back-to-back two-stage centrifugal compressor in the aviation turbocharger, the compressor is compact structure, small axial length, light weighted. Stationary parts have a great influence on their overall performance decline. Therefore, the stationary part of the back-to-back two-stage centrifugal compressor should pay full attention to the diffuser, bend, return vane and volute design. Volute also impact downstream return vane, making the flow in circumferential direction is not uniformed, and several blade angle of attack is drastically changed in downstream of the volute with the airflow can not be rotated to required angle. Loading of high-pressure rotor blades change due to non-uniformed of flow in circumferential direction, which makes individual blade load distribution changed, and affected blade passage load decreased to reduce the capability of work, the tip low speed range increases.

  13. Two stage treatment of dairy effluent using immobilized Chlorella pyrenoidosa

    PubMed Central

    2013-01-01

    Background Dairy effluents contains high organic load and unscrupulous discharge of these effluents into aquatic bodies is a matter of serious concern besides deteriorating their water quality. Whilst physico-chemical treatment is the common mode of treatment, immobilized microalgae can be potentially employed to treat high organic content which offer numerous benefits along with waste water treatment. Methods A novel low cost two stage treatment was employed for the complete treatment of dairy effluent. The first stage consists of treating the diary effluent in a photobioreactor (1 L) using immobilized Chlorella pyrenoidosa while the second stage involves a two column sand bed filtration technique. Results Whilst NH4+-N was completely removed, a 98% removal of PO43--P was achieved within 96 h of two stage purification processes. The filtrate was tested for toxicity and no mortality was observed in the zebra fish which was used as a model at the end of 96 h bioassay. Moreover, a significant decrease in biological oxygen demand and chemical oxygen demand was achieved by this novel method. Also the biomass separated was tested as a biofertilizer to the rice seeds and a 30% increase in terms of length of root and shoot was observed after the addition of biomass to the rice plants. Conclusions We conclude that the two stage treatment of dairy effluent is highly effective in removal of BOD and COD besides nutrients like nitrates and phosphates. The treatment also helps in discharging treated waste water safely into the receiving water bodies since it is non toxic for aquatic life. Further, the algal biomass separated after first stage of treatment was highly capable of increasing the growth of rice plants because of nitrogen fixation ability of the green alga and offers a great potential as a biofertilizer. PMID:24355316

  14. Two-stage dilute acid prehydrolysis of biomass

    DOEpatents

    Grohmann, Karel; Torget, Robert W.

    1992-01-01

    A two-stage dilute acid prehydrolysis process on xylan containing hemicellulose in biomass is effected by: treating feedstock of hemicellulosic material comprising xylan that is slow hydrolyzable and xylan that is fast hydrolyzable under predetermined low temperature conditions with a dilute acid for a residence time sufficient to hydrolyze the fast hydrolyzable xylan to xylose; removing said xylose from said fast hydrolyzable xylan and leaving a residue; and treating said residue having a slow hydrolyzable xylan with a dilute acid under predetermined high temperature conditions for a residence time required to hydrolyze said slow hydrolyzable xylan to xylose.

  15. Method of operating a two-stage coal gasifier

    DOEpatents

    Tanca, Michael C.

    1982-01-01

    A method of operating an entrained flow coal gasifier (10) via a two-stage gasification process. A portion of the coal (18) to be gasified is combusted in a combustion zone (30) with near stoichiometric air to generate combustion products. The combustion products are conveyed from the combustion zone into a reduction zone (32) wherein additional coal is injected into the combustion products to react with the combustion products to form a combustible gas. The additional coal is injected into the reduction zone as a mixture (60) consisting of coal and steam, preferably with a coal-to-steam weight ratio of approximately ten to one.

  16. Two-stage flow-dividing system for the calibration of vacuum gauges

    SciTech Connect

    Yoshida, Hajime; Arai, Kenta; Akimichi, Hitoshi; Hirata, Masahiro

    2008-01-15

    A two-stage flow-dividing system was developed for calibrating an ionization gauge (IG) and residual gas analyzer (RGA). This system generates a stable high and ultrahigh vacuum from 8x10{sup -3} to 2x10{sup -7} Pa by adjusting the pressure in the first chamber using N{sub 2}, Ar, He, and H{sub 2}. The calibration pressure in the third chamber is calculated from the pressure in the second chamber using their linear relation in molecular flow. The uncertainty of the generated pressure was comparable to or several times larger than that of the continuous-expansion system. However, this system has a simple configuration and is easy to operate compared with the continuous-expansion system because it has no moving parts. Results of the calibration of IG and RGA showed that the two-stage flow-dividing system is useful for a routine calibration of practical vacuum gauges in high and ultrahigh vacuum.

  17. Two-stage, close coupled catalytic liquefaction of coal

    SciTech Connect

    Comolli, A.G.; Johanson, E.S.; Panvelker, S.V.; Popper, G.A.; Smith, T.O.

    1990-09-01

    During the first quarter of 1990, work was carried out in the microautoclave, microreactor, and Bench-Scale units. An economics analysis on sub-bituminous coal processing at two space velocities was also completed. Several supported catalysts and a sample of iron oxide were screened in the microautoclave unsulfided and sulfided with DMDS and TNPS. A second shipment of Black Thunder coal from Wilsonville, oil agglomerated cleaned Illinois {number sign}6 coal from Homer City, OTISCA cleaned coal a New Mexico coal were evaluated for relative conversions with and without catalyst. Results of Bench-Scale developments with cleaned, oil agglomerated, Illinois {number sign}6 coal from Homer City(CC-6), Dispersed Catalyst/Supported Catalyst Two-Stage and reversed sequential operation (CC-7), on Black Thunder Coal (CC-7), and preliminary observations on OTISCA cleaned coal are presented. The oil agglomerated cleaned coal gave higher conversion and distillate production than the OTISCA cleaned coal. The Dispersed/Supported Two-Stage operation yielded higher gas production than the reverse sequence but also showed the higher coal conversion. Economic analysis of sub-bituminous coal processing at two space velocities showed a 3% higher return on investment with a 50% increase in space velocity. 13 tabs.

  18. Runway Operations Planning: A Two-Stage Heuristic Algorithm

    NASA Technical Reports Server (NTRS)

    Anagnostakis, Ioannis; Clarke, John-Paul

    2003-01-01

    The airport runway is a scarce resource that must be shared by different runway operations (arrivals, departures and runway crossings). Given the possible sequences of runway events, careful Runway Operations Planning (ROP) is required if runway utilization is to be maximized. From the perspective of departures, ROP solutions are aircraft departure schedules developed by optimally allocating runway time for departures given the time required for arrivals and crossings. In addition to the obvious objective of maximizing throughput, other objectives, such as guaranteeing fairness and minimizing environmental impact, can also be incorporated into the ROP solution subject to constraints introduced by Air Traffic Control (ATC) procedures. This paper introduces a two stage heuristic algorithm for solving the Runway Operations Planning (ROP) problem. In the first stage, sequences of departure class slots and runway crossings slots are generated and ranked based on departure runway throughput under stochastic conditions. In the second stage, the departure class slots are populated with specific flights from the pool of available aircraft, by solving an integer program with a Branch & Bound algorithm implementation. Preliminary results from this implementation of the two-stage algorithm on real-world traffic data are presented.

  19. Two-stage mineralization of phenanthrene by estuarine enrichment cultures

    SciTech Connect

    Guerin, W.F.; Jones, G.E.

    1988-04-01

    The polycyclic aromatic hydrocarbon phenanthrene was mineralized in two stages by soil, estuarine water, and sediment microbial populations. At high concentrations, phenanthrene was degraded, with the concomitant production of biomass and accumulation of Folin-Ciocalteau-reactive aromatic intermediates. Subsequent consumption of these intermediates resulted in a secondary increase in biomass. Analysis of intermediates by high-performance liquid chromatography, thin-layer chromatography, and UV absorption spectrometry showed 1-hydroxy-2-naphthoic acid (1H2NA) to be the predominant product. A less pronounced two-stage mineralization pattern was also observed by monitoring /sup 14/CO/sub 2/ production from low concentrations (0.5 mg liter/sup -1/) of radiolabeled phenanthrene. Here, mineralization of /sup 14/C-labeled 1H2NA could explain the incremental /sup 14/CO/sub 2/ produced during the later part of the incubations. Accumulation of 1H2NA by isolates obtained from enrichments was dependent on the initial phenanthrene concentration. The production of metabolites during polycyclic aromatic hydrocarbon biodegradation is discussed with regard to its possible adaptive significance and its methodological implications.

  20. Two-stage mineralization of phenanthrene by estuarine enrichment cultures.

    PubMed

    Guerin, W F; Jones, G E

    1988-04-01

    The polycyclic aromatic hydrocarbon phenanthrene was mineralized in two stages by soil, estuarine water, and sediment microbial populations. At high concentrations, phenanthrene was degraded, with the concomitant production of biomass and accumulation of Folin-Ciocalteau-reactive aromatic intermediates. Subsequent consumption of these intermediates resulted in a secondary increase in biomass. Analysis of intermediates by high-performance liquid chromatography, thin-layer chromatography, and UV absorption spectrometry showed 1-hydroxy-2-naphthoic acid (1H2NA) to be the predominant product. A less pronounced two-stage mineralization pattern was also observed by monitoring CO(2) production from low concentrations (0.5 mg liter) of radiolabeled phenanthrene. Here, mineralization of C-labeled 1H2NA could explain the incremental CO(2) produced during the later part of the incubations. Accumulation of 1H2NA by isolates obtained from enrichments was dependent on the initial phenanthrene concentration. The production of metabolites during polycyclic aromatic hydrocarbon biodegradation is discussed with regard to its possible adaptive significance and its methodological implications.

  1. V-band monolithic two stage HEMT amplifiers

    NASA Astrophysics Data System (ADS)

    Aust, M.; Yonaki, J.; Nakano, K.; Berenz, J.; Dow, G.

    Two different types of HEMT (high-electron-mobility transistor) monolithic low-noise amplifiers (LNAs) using AlGaAs/GaAs and pseudomorphic InGaAs/GaAs materials have been developed and have demonstrated excellent performance at 60 GHz. These monolithic LNAs have achieved noise figures of 5 dB, as well as associated gains of 11 dB. These two-stage circuits both utilize 0.2- x 60-micron HEMT devices for both bandpass and low-pass circuit topologies. Noise figures as low as 4.5 dB have been observed for single-stage MMIC- (monolithic-microwave-integrated-circuit) implemented LNAs, and gains in excess of 20 dB have been observed for three-stage versions of this amplifier with a 5-dB noise figure in the V band. This result represents the state-of-the art monolithic HEMT amplifier performance for AlGaAs and pseudomorphic InGaAs materials. This MMIC amplifier can occupy about less than one-third the size of existing MIC hybrid V-band LNAs. This represents a significant size reduction and cost saving due to repeatable circuit performance with monolithic technology. The chip sizes are both 1.6 x 2.7 mm for these two-stage amplifiers.

  2. Two-stage anaerobic digestion enables heavy metal removal.

    PubMed

    Selling, Robert; Håkansson, Torbjörn; Björnsson, Lovisa

    2008-01-01

    To fully exploit the environmental benefits of the biogas process, the digestate should be recycled as biofertiliser to agriculture. This practice can however be jeopardized by the presence of unwanted compounds such as heavy metals in the digestate. By using two-stage digestion, where the first stage includes hydrolysis/acidification and liquefaction of the substrate, heavy metals can be transferred to the leachate. From the leachate, metals can then be removed by adsorption. In this study, up to 70% of the Ni, 40% of the Zn and 25% of the Cd present in maize was removed when the leachate from hydrolysis was circulated over a macroporous polyacrylamide column for 6 days. For Cu and Pb, the mobilization in the hydrolytic stage was lower which resulted in a low removal. A more efficient two-stage process with improved substrate hydrolysis would give lower pH and/or longer periods with low pH in the hydrolytic stage. This is likely to increase metal mobilisation, and would open up for an excellent opportunity of heavy metal removal. PMID:18359995

  3. Two-stage perceptual learning to break visual crowding.

    PubMed

    Zhu, Ziyun; Fan, Zhenzhi; Fang, Fang

    2016-01-01

    When a target is presented with nearby flankers in the peripheral visual field, it becomes harder to identify, which is referred to as crowding. Crowding sets a fundamental limit of object recognition in peripheral vision, preventing us from fully appreciating cluttered visual scenes. We trained adult human subjects on a crowded orientation discrimination task and investigated whether crowding could be completely eliminated by training. We discovered a two-stage learning process with this training task. In the early stage, when the target and flankers were separated beyond a certain distance, subjects acquired a relatively general ability to break crowding, as evidenced by the fact that the breaking of crowding could transfer to another crowded orientation, even a crowded motion stimulus, although the transfer to the opposite visual hemi-field was weak. In the late stage, like many classical perceptual learning effects, subjects' performance gradually improved and showed specificity to the trained orientation. We also found that, when the target and flankers were spaced too finely, training could only reduce, rather than completely eliminate, the crowding effect. This two-stage learning process illustrates a learning strategy for our brain to deal with the notoriously difficult problem of identifying peripheral objects in clutter. The brain first learned to solve the "easy and general" part of the problem (i.e., improving the processing resolution and segmenting the target and flankers) and then tackle the "difficult and specific" part (i.e., refining the representation of the target). PMID:27105062

  4. Two-stage perceptual learning to break visual crowding.

    PubMed

    Zhu, Ziyun; Fan, Zhenzhi; Fang, Fang

    2016-01-01

    When a target is presented with nearby flankers in the peripheral visual field, it becomes harder to identify, which is referred to as crowding. Crowding sets a fundamental limit of object recognition in peripheral vision, preventing us from fully appreciating cluttered visual scenes. We trained adult human subjects on a crowded orientation discrimination task and investigated whether crowding could be completely eliminated by training. We discovered a two-stage learning process with this training task. In the early stage, when the target and flankers were separated beyond a certain distance, subjects acquired a relatively general ability to break crowding, as evidenced by the fact that the breaking of crowding could transfer to another crowded orientation, even a crowded motion stimulus, although the transfer to the opposite visual hemi-field was weak. In the late stage, like many classical perceptual learning effects, subjects' performance gradually improved and showed specificity to the trained orientation. We also found that, when the target and flankers were spaced too finely, training could only reduce, rather than completely eliminate, the crowding effect. This two-stage learning process illustrates a learning strategy for our brain to deal with the notoriously difficult problem of identifying peripheral objects in clutter. The brain first learned to solve the "easy and general" part of the problem (i.e., improving the processing resolution and segmenting the target and flankers) and then tackle the "difficult and specific" part (i.e., refining the representation of the target).

  5. An optimal stratified Simon two-stage design.

    PubMed

    Parashar, Deepak; Bowden, Jack; Starr, Colin; Wernisch, Lorenz; Mander, Adrian

    2016-07-01

    In Phase II oncology trials, therapies are increasingly being evaluated for their effectiveness in specific populations of interest. Such targeted trials require designs that allow for stratification based on the participants' molecular characterisation. A targeted design proposed by Jones and Holmgren (JH) Jones CL, Holmgren E: 'An adaptive Simon two-stage design for phase 2 studies of targeted therapies', Contemporary Clinical Trials 28 (2007) 654-661.determines whether a drug only has activity in a disease sub-population or in the wider disease population. Their adaptive design uses results from a single interim analysis to decide whether to enrich the study population with a subgroup or not; it is based on two parallel Simon two-stage designs. We study the JH design in detail and extend it by providing a few alternative ways to control the familywise error rate, in the weak sense as well as the strong sense. We also introduce a novel optimal design by minimising the expected sample size. Our extended design contributes to the much needed framework for conducting Phase II trials in stratified medicine. © 2016 The Authors Pharmaceutical Statistics Published by John Wiley & Sons Ltd.

  6. Two-stage coal gasification and desulfurization apparatus

    DOEpatents

    Bissett, Larry A.; Strickland, Larry D.

    1991-01-01

    The present invention is directed to a system which effectively integrates a two-stage, fixed-bed coal gasification arrangement with hot fuel gas desulfurization of a first stream of fuel gas from a lower stage of the two-stage gasifier and the removal of sulfur from the sulfur sorbent regeneration gas utilized in the fuel-gas desulfurization process by burning a second stream of fuel gas from the upper stage of the gasifier in a combustion device in the presence of calcium-containing material. The second stream of fuel gas is taken from above the fixed bed in the coal gasifier and is laden with ammonia, tar and sulfur values. This second stream of fuel gas is burned in the presence of excess air to provide heat energy sufficient to effect a calcium-sulfur compound forming reaction between the calcium-containing material and sulfur values carried by the regeneration gas and the second stream of fuel gas. Any ammonia values present in the fuel gas are decomposed during the combustion of the fuel gas in the combustion chamber. The substantially sulfur-free products of combustion may then be combined with the desulfurized fuel gas for providing a combustible fluid utilized for driving a prime mover.

  7. Design of a Two-Stage Light Gas Gun for Muzzle Velocities of 10 - 11 kms

    NASA Technical Reports Server (NTRS)

    Bogdanoff, David W.

    2016-01-01

    Space debris poses a major risk to spacecraft. In low earth orbit, impact velocities can be 10 11 kms and as high as 15 kms. For debris shield design, it would be desirable to be able to launch controlled shape projectiles to these velocities. The design of the proposed 10 11 kmsec gun uses, as a starting point, the Ames 1.280.22 two stage gun, which has achieved muzzle velocities of 10 11.3 kmsec. That gun is scaled up to a 0.3125 launch tube diameter. The gun is then optimized with respect to maximum pressures by varying the pump tube length to diameter ratio (LD), the piston mass and the hydrogen pressure. A pump tube LD of 36.4 is selected giving the best overall performance. Piezometric ratios for the optimized guns are found to be 2.3, much more favorable than for more traditional two stage light gas guns, which range from 4 to 6. The maximum powder chamber pressures are 20 to 30 ksi. To reduce maximum pressures, the desirable range of the included angle of the cone of the high pressure coupling is found to be 7.3 to 14.6 degrees. Lowering the break valve rupture pressure is found to lower the maximum projectile base pressure, but to raise the maximum gun pressure. For the optimized gun with a pump tube LD of 36.4, increasing the muzzle velocity by decreasing the projectile mass and increasing the powder loads is studied. It appears that saboted spheres could be launched to 10.25 and possibly as high as 10.7 10.8 kmsec, and that disc-like plastic models could be launched to 11.05 kms. The use of a tantalum liner to greatly reduce bore erosion and increase muzzle velocity is discussed. With a tantalum liner, CFD code calculations predict muzzle velocities as high as 12 to 13 kms.

  8. Advanced research and technology programs for advanced high-pressure oxygen-hydrogen rocket propulsion

    NASA Technical Reports Server (NTRS)

    Marsik, S. J.; Morea, S. F.

    1985-01-01

    A research and technology program for advanced high pressure, oxygen-hydrogen rocket propulsion technology is presently being pursued by the National Aeronautics and Space Administration (NASA) to establish the basic discipline technologies, develop the analytical tools, and establish the data base necessary for an orderly evolution of the staged combustion reusable rocket engine. The need for the program is based on the premise that the USA will depend on the Shuttle and its derivative versions as its principal Earth-to-orbit transportation system for the next 20 to 30 yr. The program is focused in three principal areas of enhancement: (1) life extension, (2) performance, and (3) operations and diagnosis. Within the technological disciplines the efforts include: rotordynamics, structural dynamics, fluid and gas dynamics, materials fatigue/fracture/life, turbomachinery fluid mechanics, ignition/combustion processes, manufacturing/producibility/nondestructive evaluation methods and materials development/evaluation. An overview of the Advanced High Pressure Oxygen-Hydrogen Rocket Propulsion Technology Program Structure and Working Groups objectives are presented with highlights of several significant achievements.

  9. Advances in crack-arrest technology for reactor pressure vessels

    SciTech Connect

    Bass, B.R.; Pugh, C.E.

    1988-01-01

    The Heavy-Section Steel Technology (HSST) Program at the Oak Ridge National Laboratory (ORNL) under the sponsorship of the US Nuclear Regulatory Commission is continuing to improve the understanding of conditions that govern the initiation, rapid propagation, arrest, and ductile tearing of cracks in reactor pressure vessel (RPV) steels. This paper describes recent advances in a coordinated effort being conducted under the HSST Program by ORNL and several subcontracting groups to develop the crack-arrest data base and the analytical tools required to construct inelastic dynamic fracture models for RPV steels. Large-scale tests are being carried out to generate crack-arrest toughness data at temperatures approaching and above the onset of Charpy upper-shelf behavior. Small- and intermediate-size specimens subjected to static and dynamic loading are being developed and tested to provide additional fracture data for RPV steels. Viscoplastic effects are being included in dynamic fracture models and computer programs and their utility validated through analyses of data from carefully controlled experiments. Recent studies are described that examine convergence problems associated with energy-based fracture parameters in viscoplastic-dynamic fracture applications. Alternative techniques that have potential for achieving convergent solutions for fracture parameters in the context of viscoplastic-dynamic models are discussed. 46 refs., 15 figs., 3 tabs.

  10. Two staged modified substitution urethroplasty using appendix-free flap.

    PubMed

    Hiradfar, Mehran; Shojaeian, Reza; Sharifabad, Parisa Saeedi

    2015-01-01

    Reconstruction of long posterior urethra defect is technically challenging. Substitution urethroplasty is used in long, complex, recurrent posterior urethral strictures. This article presents a modified technique and the clinical outcome of two-stage substitution urethroplasty with appendix free flap and microvascular anastomosis. A three-year-old boy with a 5 cm iatrogenic posterior urethral defect was managed by urethral substitution using the appendix. An appendix-free flap was used according to anatomic limitations, employing the transposed inferior epigastric artery and saphenous vein to maintain conduit blood supply. The conduit was buried in the scrotum for 3 weeks and its viability monitored until the final reconstructive stage. Two-year follow-up with ultrasound and cystoscopy revealed satisfactory results. A well-vascularised bed and flap are the mainstays of substitution urethroplasty, so we suggest inferior epigastric artery perineal transposition and staged reconstruction as alternatives that may improve the blood supply of the neourethra.

  11. Investigation on Two-Stage 300 HZ Pulse Tube Cryocooler

    NASA Astrophysics Data System (ADS)

    Cai, H. K.; Yang, L. W.; Hong, G. T.; Luo, E. C.; Zhou, Y.

    2010-04-01

    In the past few years, ultra-high frequency pulse tube cryocoolers are becoming a research hotspot for their portability and compactness in aerospace and aviation applications. For preliminary research, a two-stage pulse tube cryocooler working at 300 Hz driven by a thermoacoustic engine is established to investigate the problems due to ultra high frequency, and several results have been derived in our early reports. In order to study the effect of thermal penetration depth, this paper presents the cooler adopting copper mesh as the regenerator, and comparison with stainless steel mesh is given. In addition, the influence of inertance tube on the lowest possible cooler temperature is also tested. Finally, we discuss the improvement for getting a lower temperature.

  12. The role of two-stage repair in modern hypospadiology

    PubMed Central

    Bracka, Aivar

    2008-01-01

    Hypospadias surgery continues to evolve. The enthusiasm for flap-based urethroplasty is waning and instead there is an increasing preference for urethroplasty that uses either the urethral plate alone or in combination with grafts. From the vast armamentarium of hypospadias repairs that are still in use, the author suggests a simple protocol of just three closely related procedures with which we can now repair almost all hypospadias. The tubularised incised plate (TIP) repair and the ‘Snodgraft’ modification of the TIP principle are simple and effective one-stage solutions when partial circumference urethroplasty is required. Conversely, the Bracka two-stage graft repair remains an ideal and versatile solution when a full circumference urethroplasty is required. It is particularly appropriate for severe primary hypospadias associated with a poor plate and marked chordee and also to replace a scarred, hairy or balanitis xerotica obliterans diseased urethra in re-operative salvage hypospadias. PMID:19468400

  13. Two-stage decision approach to material accounting

    SciTech Connect

    Opelka, J.H.; Sutton, W.B.

    1982-01-01

    The validity of the alarm threshold 4sigma has been checked for hypothetical large and small facilities using a two-stage decision model in which the diverter's strategic variable is the quantity diverted, and the defender's strategic variables are the alarm threshold and the effectiveness of the physical security and material control systems in the possible presence of a diverter. For large facilities, the material accounting system inherently appears not to be a particularly useful system for the deterrence of diversions, and essentially no improvement can be made by lowering the alarm threshold below 4sigma. For small facilities, reduction of the threshold to 2sigma or 3sigma is a cost effective change for the accounting system, but is probably less cost effective than making improvements in the material control and physical security systems.

  14. Complete prostatic ablation using a two-stage laser

    NASA Astrophysics Data System (ADS)

    Sayer, Jeanie; Cromeens, Douglas M.; Price, Roger E.; Johnson, Douglas E.

    1993-05-01

    Laser photoirradiation has been delivered endoscopically for the treatment of both benign prostatic hyperplasia and early localized prostatic carcinoma. In treating carcinoma, aggressive transurethral resection of the prostate has been followed with laser irradiation to the remnants of malignant capsular disease. No attempt has been made heretofore to completely destroy the glandular prostate using laser irradiation alone. We performed a two-stage endoscopic laser prostatectomy in 6 adult mongrel dogs in an attempt to completely destroy the glandular prostate. Although no complications developed, histologic evaluation of the prostate revealed viable glandular elements in the midst of necrosis and atrophy. We conclude that in order to accomplish total ablation of the glandular prostate using laser photoirradiation, more precise thermal telemetry is needed.

  15. The design of two stage to orbit vehicles

    NASA Astrophysics Data System (ADS)

    Gregorek, G. M.; Ramsay, T. N.

    1991-09-01

    Two designs are presented for a two-stage-to-orbit vehicle to complement an existing heavy lift vehicle. The payload is 10,000 lbs and 27 ft long by 10 ft in diameter for design purposes and must be carried to a low earth orbit by an air-breathing carrier configuration that can take off horizontally within 15,000 ft. Two designs are presented: a delta wing/body carrier in which the fuselage contains the orbiter; and a cranked-delta wing/body carrier in which the orbiter is carried piggy back. The engines for both carriers are turbofanramjets powered with liquid hydrogen, and the orbiters employ either a Space Shuttle Main Engine or a half-scale version with additional scramjet engines. The orbiter based on a full-scale Space Shuttle Main Engine is found to have a significantly higher takeoff weight which results in a higher total takeoff weight.

  16. Inspection of integrated two-stage liquefaction products by petroleum assay

    SciTech Connect

    Winschel, R.A.; Zhou, P.

    1991-12-31

    A series of standard petroleum inspection tests was performed on the net product and fractions thereof from the direct liquefaction of Pittsburgh seam (Ireland Mine) coal. The product examined was generated during Run 259, period G in the catalytic/catalytic, close-coupled Integrated Two-Stage Liquefaction operating mode at the Advanced Coal Liquefaction Tests Facility in Wilsonville, Alabama. In this paper, the results of these inspection tests are reported and compared with American Society for Testing and Materials (ASTM) specifications for gasoline, jet fuel and diesel fuel. Qualitative refining requirements are inferred from the data.

  17. Inspection of integrated two-stage liquefaction products by petroleum assay

    SciTech Connect

    Winschel, R.A. ); Zhou, P. )

    1991-01-01

    A series of standard petroleum inspection tests was performed on the net product and fractions thereof from the direct liquefaction of Pittsburgh seam (Ireland Mine) coal. The product examined was generated during Run 259, period G in the catalytic/catalytic, close-coupled Integrated Two-Stage Liquefaction operating mode at the Advanced Coal Liquefaction Tests Facility in Wilsonville, Alabama. In this paper, the results of these inspection tests are reported and compared with American Society for Testing and Materials (ASTM) specifications for gasoline, jet fuel and diesel fuel. Qualitative refining requirements are inferred from the data.

  18. Runway Operations Planning: A Two-Stage Solution Methodology

    NASA Technical Reports Server (NTRS)

    Anagnostakis, Ioannis; Clarke, John-Paul

    2003-01-01

    The airport runway is a scarce resource that must be shared by different runway operations (arrivals, departures and runway crossings). Given the possible sequences of runway events, careful Runway Operations Planning (ROP) is required if runway utilization is to be maximized. Thus, Runway Operations Planning (ROP) is a critical component of airport operations planning in general and surface operations planning in particular. From the perspective of departures, ROP solutions are aircraft departure schedules developed by optimally allocating runway time for departures given the time required for arrivals and crossings. In addition to the obvious objective of maximizing throughput, other objectives, such as guaranteeing fairness and minimizing environmental impact, may be incorporated into the ROP solution subject to constraints introduced by Air Traffic Control (ATC) procedures. Generating optimal runway operations plans was approached in with a 'one-stage' optimization routine that considered all the desired objectives and constraints, and the characteristics of each aircraft (weight class, destination, Air Traffic Control (ATC) constraints) at the same time. Since, however, at any given point in time, there is less uncertainty in the predicted demand for departure resources in terms of weight class than in terms of specific aircraft, the ROP problem can be parsed into two stages. In the context of the Departure Planner (OP) research project, this paper introduces Runway Operations Planning (ROP) as part of the wider Surface Operations Optimization (SOO) and describes a proposed 'two stage' heuristic algorithm for solving the Runway Operations Planning (ROP) problem. Focus is specifically given on including runway crossings in the planning process of runway operations. In the first stage, sequences of departure class slots and runwy crossings slots are generated and ranked based on departure runway throughput under stochastic conditions. In the second stage, the

  19. Two Stage Assessment of Thermal Hazard in An Underground Mine

    NASA Astrophysics Data System (ADS)

    Drenda, Jan; Sułkowski, Józef; Pach, Grzegorz; Różański, Zenon; Wrona, Paweł

    2016-06-01

    The results of research into the application of selected thermal indices of men's work and climate indices in a two stage assessment of climatic work conditions in underground mines have been presented in this article. The difference between these two kinds of indices was pointed out during the project entitled "The recruiting requirements for miners working in hot underground mine environments". The project was coordinated by The Institute of Mining Technologies at Silesian University of Technology. It was a part of a Polish strategic project: "Improvement of safety in mines" being financed by the National Centre of Research and Development. Climate indices are based only on physical parameters of air and their measurements. Thermal indices include additional factors which are strictly connected with work, e.g. thermal resistance of clothing, kind of work etc. Special emphasis has been put on the following indices - substitute Silesian temperature (TS) which is considered as the climatic index, and the thermal discomfort index (δ) which belongs to the thermal indices group. The possibility of the two stage application of these indices has been taken into consideration (preliminary and detailed estimation). Based on the examples it was proved that by the application of thermal hazard (detailed estimation) it is possible to avoid the use of additional technical solutions which would be necessary to reduce thermal hazard in particular work places according to the climate index. The threshold limit value for TS has been set, based on these results. It was shown that below TS = 24°C it is not necessary to perform detailed estimation.

  20. Two stage ear/microtia reconstruction using costal cartilage

    PubMed Central

    Balaji, S. M.

    2015-01-01

    Background: Reconstruction of Grade III microtia is a challenging entity in maxillofacial esthetic rehabilitation. Several advocacies and philosophies exist in this field. The aim of the manuscript is to present a single South Indian Experience with Ear reconstruction among South Indian Population. Materials and Methods: Retrospective analysis of unilateral Grade III microtia reconstruction was performed. Using a set of predefined inclusion and exclusion criteria, the population was selected. Outcome measures in terms of the ear size, auriculocephalic angle, and the conchal depth were measured in the reconstructed and normal side. Descriptive statistics is presented. Results: Twenty-four patients formed the study group and had undergone the classical two-stage reconstruction in a similar fashion. The mean ear size in normal side was 65.8 ± 2.8 mm whereas on the reconstructed side, it was 61.3 ± 5.8 mm. The center's technique achieved above 75% similarity as that of the other normal ear. The mean auriculocephalic angle was 44.6 ± 5.2° whereas for the surgically reconstructed ear, it was 41.9 ± 2.6°. Overall, in these patients, we achieved a 79.94% similarity of auriculocephalic angle in the reconstructed ear as compared to the normal auricle. The conchal depth was 19.2 ± 2.1 mm and 16.6 ± 1.9 mm for normal and reconstructed ear, respectively. In terms of conchal depth, the present study group showed an achievement of 82.88% of accuracy even after a prolonged follow-up. Discussion and Conclusion: The center employs a classic two stage reconstruction with a customized prosthesis that helps to avoid the loss of projection geometry and minimizes adhesion, infection, and early loss of structural stability. PMID:26981464

  1. Two-stage coprocessing of waste plastics with coal

    SciTech Connect

    Ding, Weibing; Liang, Jing; Anderson, L.L.

    1996-12-31

    Commingled post-consumer plastic waste (CP No. 2) or high density polyethylene (HDPE) was found to be thermally degraded only at temperatures higher than 430{degrees}C, while typical coal liquefaction temperatures are about 400{degrees}C. This causes difficulty for coprocessing coal with waste plastic in single stage at appropriate reaction conditions. Moreover, it is hard to find a catalyst which is effective for depolymerization of both coal and HDPE or CP No. 2. In this study, two-stage coprocessing was developed to produce liquid fuels. In the first stage, CP No. 2 or HDPE was liquefied in an 150-cm{sup 3} autoclave reactor at 435{degrees}C, 1 hr, with stirring speed of 800 rpm, under N2 or H2 with and without catalyst (HZSM-5). The resulting liquid products (yields of 78-88 wt%) were utilized as solvents for liquefaction of DECS-6 coal or Fe loaded DECS-6 coal in tubing reactors at 400{degrees}C, 1 hr, 160 rpm, {approximately}2000 psig H{sub 2}.

  2. Two-Stage, 90-GHz, Low-Noise Amplifier

    NASA Technical Reports Server (NTRS)

    Samoska, Lorene A.; Gaier, Todd C.; Xenos, Stephanie; Soria, Mary M.; Kangaslahti, Pekka P.; Cleary, Kieran A.; Ferreira, Linda; Lai, Richard; Mei, Xiaobing

    2010-01-01

    A device has been developed for coherent detection of the polarization of the cosmic microwave background (CMB). A two-stage amplifier has been designed that covers 75-110 GHz. The device uses the emerging 35-nm InP HEMT technology recently developed at Northrop Grumman Corporation primarily for use at higher frequencies. The amplifier has more than 18 dB gain and less than 35 K noise figure across the band. These devices have noise less than 30 K at 100 GHz. The development started with design activities at JPL, as well as characterization of multichip modules using existing InP. Following processing, a test campaign was carried out using single-chip modules at 100 GHz. Successful development of the chips will lead to development of multichip modules, with simultaneous Q and U Stokes parameter detection. This MMIC (monolithic microwave integrated circuit) amplifier takes advantage of performance improvements intended for higher frequencies, but in this innovation are applied at 90 GHz. The large amount of available gain ultimately leads to lower possible noise performance at 90 GHz.

  3. Apparatus and method for two-stage oxidation of wastes

    DOEpatents

    Fleischman, Scott D.

    1995-01-01

    An apparatus and method for oxidizing wastes in a two-stage process. The apparatus includes an oxidation device, a gas-liquid contacting column and an electrocell. In the first stage of the process, wastes are heated in the presence of air to partially oxidize the wastes. The heated wastes produce an off-gas stream containing oxidizable materials. In the second stage, the off-gas stream is cooled and flowed through the contacting column, where the off-gas stream is contacted with an aqueous acid stream containing an oxidizing agent having at least two positive valence states. At least a portion of the oxidizable materials are transferred to the acid stream and destroyed by the oxidizing agent. During oxidation, the valence of the oxidizing agent is decreased from its higher state to its lower state. The acid stream is flowed to the electrocell, where an electric current is applied to the stream to restore the oxidizing agent to its higher valence state. The regenerated acid stream is recycled to the contacting column.

  4. DeNOx characteristics using two staged radical injection techniques

    SciTech Connect

    Kambara, S.; Kumano, Y.; Yukimura, K.

    2009-06-15

    Ammonia radical injection using pulsed dielectric barrier discharge (DBD) plasma has been investigated as a means to control NOx emissions from combustors. When DBD plasma-generated radicals (NH{sub 2}, NH, N, and H) are injected into a flue gas containing nitrogen oxide (NOx), NOx is removed efficiently by chain reactions in the gas phase. However, because the percentage of NOx removal gradually decreases with increasing oxygen concentrations beyond 1% O{sub 2}, improvement of the DeNOx (removal of nitrogen oxide) characteristics at high O{sub 2} concentrations was necessary for commercial combustors. A two-staged injection of the DeNOx agent was developed based on the detailed mechanisms of electron impact reactions and gas phase reactions. A concentration of H radical was observed to play an important role in NOx formation and removal. The effects of applied voltages, oxygen concentrations, and reaction temperatures on NOx removal were investigated under normal and staged injection. NOx removal was improved by approximately 20% using staged injection at O{sub 2} concentrations of 1 to 4%.

  5. Inherent structures and two-stage melting in two dimensions

    NASA Astrophysics Data System (ADS)

    Somer, Frank; Canright, Geoff; Kaplan, Ted; Mostoller, Mark; Chen, Kun

    1997-03-01

    Inherent structures and two-stage melting in two dimensions Frank Somer, Geoff Canright, University of Tennessee and Solid State Division (SSD), Oak Ridge National Laboratory (ORNL), Ted Kaplan, Mark Mostoller, Kun Chen, SSD, ORNL -- A large-scale computational study of the mechanically stable "inherent structures" (IS) associated with equilibrium two-dimensional Lennard-Jones systems is presented. It is found that the IS clearly distinguish among different equilibrium phases, thus providing strong confirmation of the inherent-structures concept of Stillinger and Weber, for simple 2D fluids. This study is also relevant to the theory of Kosterlitz, Thouless, Halperin, Nelson, and Young (KTHNY), which implicitly assumes the mechanical stability of the topological defects. While the IS associated with the crystalline and hexatic phases are found to be in clear agreement with KTHNY, the liquid IS show percolating networks of grain boundaries, rather than the free disclinations that might be expected on the basis of KTHNY. Evidence is presented, however, that free disclinations can relax to networks of grain boundaries. Hence, the three `phases' of IS found are, in principle, consistent with the three equilibrium phases of KTHNY.

  6. Cox regression methods for two-stage randomization designs.

    PubMed

    Lokhnygina, Yuliya; Helterbrand, Jeffrey D

    2007-06-01

    Two-stage randomization designs (TSRD) are becoming increasingly common in oncology and AIDS clinical trials as they make more efficient use of study participants to examine therapeutic regimens. In these designs patients are initially randomized to an induction treatment, followed by randomization to a maintenance treatment conditional on their induction response and consent to further study treatment. Broader acceptance of TSRDs in drug development may hinge on the ability to make appropriate intent-to-treat type inference within this design framework as to whether an experimental induction regimen is better than a standard induction regimen when maintenance treatment is fixed. Recently Lunceford, Davidian, and Tsiatis (2002, Biometrics 58, 48-57) introduced an inverse probability weighting based analytical framework for estimating survival distributions and mean restricted survival times, as well as for comparing treatment policies at landmarks in the TSRD setting. In practice Cox regression is widely used and in this article we extend the analytical framework of Lunceford et al. (2002) to derive a consistent estimator for the log hazard in the Cox model and a robust score test to compare treatment policies. Large sample properties of these methods are derived, illustrated via a simulation study, and applied to a TSRD clinical trial. PMID:17425633

  7. A two-stage model of fracture of rocks

    USGS Publications Warehouse

    Kuksenko, V.; Tomilin, N.; Damaskinskaya, E.; Lockner, D.

    1996-01-01

    In this paper we propose a two-stage model of rock fracture. In the first stage, cracks or local regions of failure are uncorrelated occur randomly throughout the rock in response to loading of pre-existing flaws. As damage accumulates in the rock, there is a gradual increase in the probability that large clusters of closely spaced cracks or local failure sites will develop. Based on statistical arguments, a critical density of damage will occur where clusters of flaws become large enough to lead to larger-scale failure of the rock (stage two). While crack interaction and cooperative failure is expected to occur within clusters of closely spaced cracks, the initial development of clusters is predicted based on the random variation in pre-existing Saw populations. Thus the onset of the unstable second stage in the model can be computed from the generation of random, uncorrelated damage. The proposed model incorporates notions of the kinetic (and therefore time-dependent) nature of the strength of solids as well as the discrete hierarchic structure of rocks and the flaw populations that lead to damage accumulation. The advantage offered by this model is that its salient features are valid for fracture processes occurring over a wide range of scales including earthquake processes. A notion of the rank of fracture (fracture size) is introduced, and criteria are presented for both fracture nucleation and the transition of the failure process from one scale to another.

  8. A two-stage DEA approach for environmental efficiency measurement.

    PubMed

    Song, Malin; Wang, Shuhong; Liu, Wei

    2014-05-01

    The slacks-based measure (SBM) model based on the constant returns to scale has achieved some good results in addressing the undesirable outputs, such as waste water and water gas, in measuring environmental efficiency. However, the traditional SBM model cannot deal with the scenario in which desirable outputs are constant. Based on the axiomatic theory of productivity, this paper carries out a systematic research on the SBM model considering undesirable outputs, and further expands the SBM model from the perspective of network analysis. The new model can not only perform efficiency evaluation considering undesirable outputs, but also calculate desirable and undesirable outputs separately. The latter advantage successfully solves the "dependence" problem of outputs, that is, we can not increase the desirable outputs without producing any undesirable outputs. The following illustration shows that the efficiency values obtained by two-stage approach are smaller than those obtained by the traditional SBM model. Our approach provides a more profound analysis on how to improve environmental efficiency of the decision making units.

  9. Laparoscopic management of a two staged gall bladder torsion.

    PubMed

    Sunder, Yadav Kamal; Akhilesh, Sali Priyanka; Raman, Garg; Deborshi, Sharma; Shantilal, Mehta Hitesh

    2015-12-27

    Gall bladder torsion (GBT) is a relatively uncommon entity and rarely diagnosed preoperatively. A constant factor in all occurrences of GBT is a freely mobile gall bladder due to congenital or acquired anomalies. GBT is commonly observed in elderly white females. We report a 77-year-old, Caucasian lady who was originally diagnosed as gall bladder perforation but was eventually found with a two staged torsion of the gall bladder with twisting of the Riedel's lobe (part of tongue like projection of liver segment 4A). This together, has not been reported in literature, to the best of our knowledge. We performed laparoscopic cholecystectomy and she had an uneventful post-operative period. GBT may create a diagnostic dilemma in the context of acute cholecystitis. Timely diagnosis and intervention is necessary, with extra care while operating as the anatomy is generally distorted. The fundus first approach can be useful due to altered anatomy in the region of Calot's triangle. Laparoscopic cholecystectomy has the benefit of early recovery. PMID:26730287

  10. Apparatus and method for two-stage oxidation of wastes

    SciTech Connect

    Fleischman, S.D.

    1993-09-28

    An apparatus and method for oxidizing wastes in a two-stage process. The apparatus includes an oxidation device, a gas-liquid contacting column and an electrocell. In the first stage of the process, wastes are heated in the presence of air to partially oxidize the wastes. The heated wastes produce an off-gas stream containing oxidizable materials. In the second stage, the off-gas stream is cooled and flowed through the contacting column, where the off-gas stream is contacted with an aqueous acid stream containing an oxidizing agent having at least two positive valence states. At least a portion of the oxidizable materials are transferred to the acid stream and destroyed by the oxidizing agent. During oxidation, the valence of the oxidizing agent is decreased from its higher state to its lower state. The acid stream is flowed to the electrocell, where an electric current is applied to the stream to restore the oxidizing agent to its higher valence state. The regenerated acid stream is recycled to the contacting column.

  11. Object Proposal Generation Using Two-Stage Cascade SVMs.

    PubMed

    Zhang, Ziming; Torr, Philip H S

    2016-01-01

    Object proposal algorithms have shown great promise as a first step for object recognition and detection. Good object proposal generation algorithms require high object detection recall rate as well as low computational cost, because generating object proposals is usually utilized as a preprocessing step. The problem of how to accelerate the object proposal generation and evaluation process without decreasing recall is thus of great interest. In this paper, we propose a new object proposal generation method using two-stage cascade support vector machines (SVMs), where in the first stage linear filters are learned for predefined quantized scales/aspect-ratios independently, and in the second stage a global linear classifier is learned across all the quantized scales/aspect-ratios for calibration, so that all the windows from the first stage can be compared properly. The windows with highest scores from the second stage are kept as inputs to our new efficient proposal calibration algorithm to improve their localization quality significantly, resulting in our final object proposals. We explain our scale/aspect-ratio quantization scheme, and investigate the effects of combinations of l1 and l2 regularizers in cascade SVMs with/without ranking constraints in learning. Comprehensive experiments on VOC2007 dataset are conducted, and our method is comparable with the current state-of-the-art methods with much better computational efficiency.

  12. Electron acceleration in a two-stage laser wakefield accelerator

    NASA Astrophysics Data System (ADS)

    Li, Ruxin; Liu, Jiansheng; Xia, Changquan; Wang, Wentao; Lu, Haiyang; Wang, Cheng; Deng, Aihua; Li, Wentao; Zhang, Hui; Liang, Xiaoyan; Leng, Yuxin; Lu, Xiaoming; Wang, Cheng; Wang, Jianzhou; Shen, Baifei; Nakajima, Kazuhisa; Xu, Zhizhan

    2012-07-01

    Near-GeV electron beam generation from a two-stage laser wakefield accelerator (LWFA) is reported. Electron injection and acceleration are separated into two distinct LWFA stages and controlled independently from each other by employing two gas cells filled with a He/O2 mixture and pure He gas, respectively. Electrons with a Maxwellian spectrum, generated from the injection stage assisted by ionization-induced injection, are seeded into the acceleration stage with a 3-mm long gas cell and accelerated to produce a 0.8-GeV quasimonoenergetic electron beam for a 45 TW 40 fs laser pulse, corresponding to an acceleration gradient of 187 GV/m. In the injection stage, the produced electron beam properties can be optimized by adjusting the input laser intensity and the plasma density so that quasimonoenergetic electron beams are obtained owing to the self-focusing effects of the laser beam. The ionization-induced injection scheme has been extensively employed for a capillary discharge plasma waveguide to demonstrate channel-guided LWFA beyond 1 GeV. Using a 4-cm capillary made of oxygen containing acrylic resin results in optically guiding 130 TW 55 fs laser pulse that accelerates electrons up to 1.8 GeV in contrast with no electron acceleration in a polyethylene capillary free of oxygen.

  13. Baseplate for two-stage cranial mounting of BMI connectors

    NASA Astrophysics Data System (ADS)

    McMorland, Angus J. C.; Velliste, Meel

    2013-06-01

    Objective. Intracortical electrode arrays provide the best spatial and temporal resolution signals for brain-machine interfaces. Wireless technologies are being developed to handle this information capacity, but currently the only means to deliver neural information from the implant to a signal processing unit is by a physical connection starting at a skull-mounted connector. The failure rate of the attachment of these connectors is significant. In this study we report an improvement to the traditional connectors. Approach. We have designed and applied an intermediary mounting plate that incorporates several features that provide better, more stable fixation to the skull: (1) wide legs allowing distribution of loading forces and distancing the intracranial screws from the skin interface, (2) a thin shelf to allow early osseointegration, (3) a concave interior to accommodate the curvature of the cranium, and (4) two-stage fixation process providing time for osseointegration prior to the application of loading forces from the connector. Main results. Six baseplates, over four design iterations, have now been tested in three non-human primates. The baseplates are associated with a substantially lower attachment failure rate. Significance. Our baseplate design improves on the current skull-mounted connectors, leading to better outcomes for subjects and fewer catastrophic failure events that can terminate resource intensive intracortical recording experiments.

  14. Two-stage process for conversion of alkanes to gasoline

    SciTech Connect

    Harandi, M.N.; Owen, H.

    1989-08-22

    This patent describes an improvement in a two-stage process for upgrading hydrocarbons in at least four reaction zones cooperating to produce gasoline range hydrocarbons from lower alkanes. The reaction zones comprising first reaction zone to crack gas oil range hydrocarbons utilizing a large pore cracking catalyst, a second reaction zone in which the large pore catalyst is oxidatively regenerated, a third reaction zone in which an external catalyst cooler autogeneously cools regenerated catalyst by dehydrogenation of the lower alkane stream to produce an olefinic effluent, and a fourth reaction zone in which the olefinic effluent is oligomerized to the gasoline range hydrocarbons. The improvement comprising: a first stage, comprising utilizing excess heat from the second reaction zone: contacting the hot fluid catalytic cracking catalyst with C/sub 3//sup +/ alkanes in the third reaction zone to provide conversion of the alkanes to olefins which leave the third reaction zone as the olefinic effluent separated from catalyst; returning a specified amount of separate fluid catalytic cracking catalyst from the third reaction zone directly to the first or second reaction zone; a second state comprising passing the olefinic effluent from the third reaction zone to a fourth reaction zone for oligomerizing olefins to gasoline range hydrocarbons contacting the olefinic effluent with a medium pore zeolite catalyst effective; recovering a gasoline range hydrocarbon stream from the effluent of the fourth reaction zone.

  15. Plant responses to reduced air pressure: advanced techniques and results

    NASA Astrophysics Data System (ADS)

    Daunicht, H.-J.; Brinkjans, H. J.

    1996-01-01

    Knowledge on air pressure impacts on plant processes and growth is essential for understanding responses to altitude and for comprehending the way of action of aerial gasses in general, and is of potential importance for life support systems in space. Our research on reduced air pressure was extended by help of a new set-up comprising two constantly ventilated chambers (283 L each), allowing pressure gradients of +/- 100 kPa. They provide favourable general growth conditions while maintaining all those factors constant or at desired levels which modify the action of air pressure, e.g. water vapour pressure deficit and air mass flow over the plants. Besides plant growth parameters, transpiration and CO_2 gas exchange are determined continuously. Results are presented on young tomato plants grown hydroponically, which had been treated with various combinations of air pressure (400 - 700 - 1000 hPa), CO_2 concentration and wind intensity for seven days. At the lowest pressure transpiration was enhanced considerably, and the plants became sturdier. On the other hand growth was retarded to a certain extent, attributable to secondary air pressure effects. Therefore, even greater limitations of plant productivity are expected after more extended periods of low pressure treatment.

  16. Two-stage Catalytic Reduction of NOx with Hydrocarbons

    SciTech Connect

    Umit S. Ozkan; Erik M. Holmgreen; Matthew M. Yung; Jonathan Halter; Joel Hiltner

    2005-12-21

    A two-stage system for the catalytic reduction of NO from lean-burn natural gas reciprocating engine exhaust is investigated. Each of the two stages uses a distinct catalyst. The first stage is oxidation of NO to NO{sub 2} and the second stage is reduction of NO{sub 2} to N{sub 2} with a hydrocarbon. The central idea is that since NO{sub 2} is a more easily reduced species than NO, it should be better able to compete with oxygen for the combustion reaction of hydrocarbon, which is a challenge in lean conditions. Early work focused on demonstrating that the N{sub 2} yield obtained when NO{sub 2} was reduced was greater than when NO was reduced. NO{sub 2} reduction catalysts were designed and silver supported on alumina (Ag/Al{sub 2}O{sub 3}) was found to be quite active, able to achieve 95% N{sub 2} yield in 10% O{sub 2} using propane as the reducing agent. The design of a catalyst for NO oxidation was also investigated, and a Co/TiO{sub 2} catalyst prepared by sol-gel was shown to have high activity for the reaction, able to reach equilibrium conversion of 80% at 300 C at GHSV of 50,000h{sup -1}. After it was shown that NO{sub 2} could be more easily reduced to N{sub 2} than NO, the focus shifted on developing a catalyst that could use methane as the reducing agent. The Ag/Al{sub 2}O{sub 3} catalyst was tested and found to be inactive for NOx reduction with methane. Through iterative catalyst design, a palladium-based catalyst on a sulfated-zirconia support (Pd/SZ) was synthesized and shown to be able to selectively reduce NO{sub 2} in lean conditions using methane. Development of catalysts for the oxidation reaction also continued and higher activity, as well as stability in 10% water, was observed on a Co/ZrO{sub 2} catalyst, which reached equilibrium conversion of 94% at 250 C at the same GHSV. The Co/ZrO{sub 2} catalyst was also found to be extremely active for oxidation of CO, ethane, and propane, which could potential eliminate the need for any separate

  17. Frog Virus 3 DNA Replication Occurs in Two Stages

    PubMed Central

    Goorha, R.

    1982-01-01

    Viral DNA synthesis in frog virus 3 (FV3)-infected cells occurs both in the nucleus and in the cytoplasm (Goorha et al., Virology 84:32-51, 1978). Relationships between viral DNA molecules synthesized in these two compartments and their role in the virus replication were examined. The data presented here suggest that (i) FV3 DNA replicated in two stages and (ii) nucleus and cytoplasm were the sites of stages 1 and 2 of DNA replication, respectively. Stages 1 and 2 were further distinguished by their temporal appearance during infection and by the sizes of the replicating DNA as determined by sedimentation in neutral sucrose gradients. In stage 1, replicating molecules, between the size of unit and twice the unit length, were produced early in infection (2 h postinfection). In contrast, stage 2 of DNA replication occurred only after 3 h postinfection, and replicating molecules were large concatemers. Results of pulse-chase experiments showed that the concatemeric DNA served as the precursor for the production of mature FV3 DNA. Denaturation of concatemeric DNA with alkali or digestion with S1 nuclease reduced it to less than genome size molecules, indicating the presence of extensive single-stranded regions. Analysis of replicating DNA by equilibrium centrifugation in CsCl gradients after a pulse-chase suggested that these single-stranded regions were subsequently repaired. Based on these and previous data, a scheme of FV3 replication is presented. According to this scheme, FV3 utilizes the nucleus for early transcription and stage 1 of DNA replication. The viral DNA is then transported to the cytoplasm, where it participates in stage 2 DNA replication to form a concatemeric replication complex. The processing of concatemers to produce mature viral DNA and virus assembly also occurs in the cytoplasm. This mode of replication is strikingly different from any other known DNA virus. PMID:7109033

  18. Metamodeling and Optimization of a Blister Copper Two-Stage Production Process

    NASA Astrophysics Data System (ADS)

    Jarosz, Piotr; Kusiak, Jan; Małecki, Stanisław; Morkisz, Paweł; Oprocha, Piotr; Pietrucha, Wojciech; Sztangret, Łukasz

    2016-06-01

    It is often difficult to estimate parameters for a two-stage production process of blister copper (containing 99.4 wt.% of Cu metal) as well as those for most industrial processes with high accuracy, which leads to problems related to process modeling and control. The first objective of this study was to model flash smelting and converting of Cu matte stages using three different techniques: artificial neural networks, support vector machines, and random forests, which utilized noisy technological data. Subsequently, more advanced models were applied to optimize the entire process (which was the second goal of this research). The obtained optimal solution was a Pareto-optimal one because the process consisted of two stages, making the optimization problem a multi-criteria one. A sequential optimization strategy was employed, which aimed for optimal control parameters consecutively for both stages. The obtained optimal output parameters for the first smelting stage were used as input parameters for the second converting stage. Finally, a search for another optimal set of control parameters for the second stage of a Kennecott-Outokumpu process was performed. The optimization process was modeled using a Monte-Carlo method, and both modeling parameters and computed optimal solutions are discussed.

  19. Fueling of magnetically confined plasmas by single- and two-stage repeating pneumatic pellet injectors

    SciTech Connect

    Gouge, M.J.; Combs, S.K.; Foust, C.R.; Milora, S.L.

    1990-01-01

    Advanced plasma fueling systems for magnetic fusion confinement experiments are under development at Oak Ridge National Laboratory (ORNL). The general approach is that of producing and accelerating frozen hydrogenic pellets to speeds in the kilometer-per-second range using single shot and repetitive pneumatic (light-gas gun) pellet injectors. The millimeter-to-centimeter size pellets enter the plasma and continuously ablate because of the plasma electron heat flux, depositing fuel atoms along the pellet trajectory. This fueling method allows direct fueling in the interior of the hot plasma and is more efficient than the alternative method of injecting room temperature fuel gas at the wall of the plasma vacuum chamber. Single-stage pneumatic injectors based on the light-gas gun concept have provided hydrogenic fuel pellets in the speed range of 1--2 km/s in single-shot injector designs. Repetition rates up to 5 Hz have been demonstrated in repetitive injector designs. Future fusion reactor-scale devices may need higher pellet velocities because of the larger plasma size and higher plasma temperatures. Repetitive two-stage pneumatic injectors are under development at ORNL to provide long-pulse plasma fueling in the 3--5 km/s speed range. Recently, a repeating, two-stage light-gas gun achieved repetitive operation at 1 Hz with speeds in the range of 2--3 km/s.

  20. Two stages and three components of the postural preparation to action.

    PubMed

    Krishnan, Vennila; Aruin, Alexander S; Latash, Mark L

    2011-07-01

    Previous studies of postural preparation to action/perturbation have primarily focused on anticipatory postural adjustments (APAs), the changes in muscle activation levels resulting in the production of net forces and moments of force. We hypothesized that postural preparation to action consists of two stages: (1) Early postural adjustments (EPAs), seen a few hundred ms prior to an expected external perturbation and (2) APAs seen about 100 ms prior to the perturbation. We also hypothesized that each stage consists of three components, anticipatory synergy adjustments seen as changes in covariation of the magnitudes of commands to muscle groups (M-modes), changes in averaged across trials levels of muscle activation, and mechanical effects such as shifts of the center of pressure. Nine healthy participants were subjected to external perturbations created by a swinging pendulum while standing in a semi-squatting posture. Electrical activity of twelve trunk and leg muscles and displacements of the center of pressure were recorded and analyzed. Principal component analysis was used to identify four M-modes within the space of muscle activations using indices of integrated muscle activation. This analysis was performed twice, over two phases, 400-700 ms prior to the perturbation and over 200 ms just prior to the perturbation. Similar robust results were obtained using the data from both phases. An index of a multi-M-mode synergy stabilizing the center of pressure displacement was computed using the framework of the uncontrolled manifold hypothesis. The results showed high synergy indices during quiet stance. Each of the two stages started with a drop in the synergy index followed by a change in the averaged across trials activation levels in postural muscles. There was a very long electromechanical delay during the early postural adjustments and a much shorter delay during the APAs. Overall, the results support our main hypothesis on the two stages and three components

  1. TWO STAGES AND THREE COMPONENTS OF THE POSTURAL PREPARATION TO ACTION

    PubMed Central

    Krishnan, Vennila; Aruin, Alexander S.; Latash, Mark L.

    2013-01-01

    Previous studies of postural preparation to action/perturbation have primarily focused on anticipatory postural adjustments (APAs), the changes in muscle activation levels resulting in the production of net forces and moments of force. We hypothesized that postural preparation to action consists of two stages: (1) Early postural adjustments (EPAs), seen a few hundred ms prior to an expected external perturbation; and (2) APAs seen about 100 ms prior to the perturbation. We also hypothesized that each stage consists of three components, anticipatory synergy adjustments seen as changes in co-variation of the magnitudes of commands to muscle groups (M-modes), changes in averaged across trials levels of muscle activation, and mechanical effects such as shifts of the center of pressure. Nine healthy participants were subjected to external perturbations created by a swinging pendulum while standing in a semi-squatting posture. Electrical activity of twelve trunk and leg muscles and displacements of the center of pressure were recorded and analyzed. Principal component analysis was used to identify four M-modes within the space of muscle activations using indices of integrated muscle activation. This analysis was performed twice, over two phases, 400-700 ms prior to the perturbation and over 200 ms just prior to the perturbation. Similar robust results were obtained using the data from both phases. An index of a multi-M-mode synergy stabilizing the center of pressure displacement was computed using the framework of the uncontrolled manifold hypothesis. The results showed high synergy indices during quiet stance. Each of the two stages started with a drop in the synergy index followed by a change in the averaged across trials activation levels in postural muscles. There was a very long electromechanical delay during the early postural adjustments and a much shorter delay during the APAs. Overall, the results support our main hypothesis on the two stages and three

  2. Advanced composite fiber/metal pressure vessels for aircraft applications

    NASA Astrophysics Data System (ADS)

    Papanicolopoulos, Aleck

    1993-06-01

    Structural Composites Industries has developed, qualified, and delivered a number of high performance carbon epoxy overwrapped/seamless aluminum liner pressure vessels for use in military aircraft where low weight, low cost, high operating pressure and short lead time are the primary considerations. This paper describes product design, development, and qualification for a typical program. The vessel requirements included a munitions insensitivity criterion as evidenced by no fragmentation following impact by a .50 cal tumbling bullet. This was met by the development of a carbon-Spectra hybrid composite overwrap on a thin-walled seamless aluminum liner. The same manufacturing, inspection, and test processes that are used to produce lightweight, thin walled seamless aluminum lined carbon/epoxy overwrapped pressure vessels for satellite and other space applications were used to fabricate this vessel. This report focuses on the results of performance in the qualification testing.

  3. Two-stage coal liquefaction without gas-phase hydrogen

    DOEpatents

    Stephens, H.P.

    1986-06-05

    A process is provided for the production of a hydrogen-donor solvent useful in the liquefaction of coal, wherein the water-gas shift reaction is used to produce hydrogen while simultaneously hydrogenating a donor solvent. A process for the liquefaction of coal using said solvent is also provided. The process enables avoiding the use of a separate water-gas shift reactor as well as high pressure equipment for liquefaction. 3 tabs.

  4. High-Energy Two-Stage Pulsed Plasma Thruster

    NASA Technical Reports Server (NTRS)

    Markusic, Tom

    2003-01-01

    A high-energy (28 kJ per pulse) two-stage pulsed plasma thruster (MSFC PPT-1) has been constructed and tested. The motivation of this project is to develop a high power (approximately 500 kW), high specific impulse (approximately 10000 s), highly efficient (greater than 50%) thruster for use as primary propulsion in a high power nuclear electric propulsion system. PPT-1 was designed to overcome four negative characteristics which have detracted from the utility of pulsed plasma thrusters: poor electrical efficiency, poor propellant utilization efficiency, electrode erosion, and reliability issues associated with the use of high speed gas valves and high current switches. Traditional PPTs have been plagued with poor efficiency because they have not been operated in a plasma regime that fully exploits the potential benefits of pulsed plasma acceleration by electromagnetic forces. PPTs have generally been used to accelerate low-density plasmas with long current pulses. Operation of thrusters in this plasma regime allows for the development of certain undesirable particle-kinetic effects, such as Hall effect-induced current sheet canting. PPT-1 was designed to propel a highly collisional, dense plasma that has more fluid-like properties and, hence, is more effectively pushed by a magnetic field. The high-density plasma loading into the second stage of the accelerator is achieved through the use of a dense plasma injector (first stage). The injector produces a thermal plasma, derived from a molten lithium propellant feed system, which is subsequently accelerated by the second stage using mega-amp level currents, which eject the plasma at a speed on the order of 100 kilometers per second. Traditional PPTs also suffer from dynamic efficiency losses associated with snowplow loading of distributed neutral propellant. The twostage scheme used in PPT-I allows the propellant to be loaded in a manner which more closely approximates the optimal slug loading. Lithium propellant

  5. Advanced Decontamination Technologies: High Hydrostatic Pressure on Meat Products

    NASA Astrophysics Data System (ADS)

    Garriga, Margarita; Aymerich, Teresa

    The increasing demand for “natural” foodstuffs, free from chemical additives, and preservatives has triggered novel approaches in food technology developments. In the last decade, practical use of high-pressure processing (HPP) made this emerging non-thermal technology very attractive from a commercial point of view. Despite the fact that the investment is still high, the resulting value-added products, with an extended and safe shelf-life, will fulfil the wishes of consumers who prefer preservative-free minimally processed foods, retaining sensorial characteristics of freshness. Moreover, unlike thermal treatment, pressure treatment is not time/mass dependant, thus reducing the time of processing.

  6. Simulation Studies of Two-Stage Ability Testing. Research Report 74-4.

    ERIC Educational Resources Information Center

    Betz, Nancy E.; Weiss, David J.

    Monte Carlo simulation procedures were used to study the psychometric characteristics of two two-stage adaptive tests and a conventional "peaked" ability test. Results showed that scores yielded by both two-stage tests better reflected the normal distribution of underlying ability. Ability estimates yielded by one of the two stage tests were more…

  7. Two-Stage Exams Improve Student Learning in an Introductory Geology Course: Logistics, Attendance, and Grades

    ERIC Educational Resources Information Center

    Knierim, Katherine; Turner, Henry; Davis, Ralph K.

    2015-01-01

    Two-stage exams--where students complete part one of an exam closed book and independently and part two is completed open book and independently (two-stage independent, or TS-I) or collaboratively (two-stage collaborative, or TS-C)--provide a means to include collaborative learning in summative assessments. Collaborative learning has been shown to…

  8. Recent Advances in Food Processing Using High Hydrostatic Pressure Technology.

    PubMed

    Wang, Chung-Yi; Huang, Hsiao-Wen; Hsu, Chiao-Ping; Yang, Binghuei Barry

    2016-01-01

    High hydrostatic pressure is an emerging non-thermal technology that can achieve the same standards of food safety as those of heat pasteurization and meet consumer requirements for fresher tasting, minimally processed foods. Applying high-pressure processing can inactivate pathogenic and spoilage microorganisms and enzymes, as well as modify structures with little or no effects on the nutritional and sensory quality of foods. The U.S. Food and Drug Administration (FDA) and the U.S. Department of Agriculture (USDA) have approved the use of high-pressure processing (HPP), which is a reliable technological alternative to conventional heat pasteurization in food-processing procedures. This paper presents the current applications of HPP in processing fruits, vegetables, meats, seafood, dairy, and egg products; such applications include the combination of pressure and biopreservation to generate specific characteristics in certain products. In addition, this paper describes recent findings on the microbiological, chemical, and molecular aspects of HPP technology used in commercial and research applications.

  9. Time Pressure and Phonological Advance Planning in Spoken Production

    ERIC Educational Resources Information Center

    Damian, Markus F.; Dumay, Nicolas

    2007-01-01

    Current accounts of spoken production debate the extent to which speakers plan ahead. Here, we investigated whether the scope of phonological planning is influenced by changes in time pressure constraints. The first experiment used a picture-word interference task and showed that picture naming latencies were shorter when word distractors shared…

  10. From wastewater to bioenergy and biochemicals via two-stage bioconversion processes: a future paradigm.

    PubMed

    Li, Wen-Wei; Yu, Han-Qing

    2011-01-01

    Recovery of bioenergy and biochemicals from wastewater has attracted growing and widespread interests. In this respect, two-stage bioconversion process (TSBP) offers an appealing avenue to achieve stepwise and directional substrate conversion in separated stages. Such a biosystem not only enables enhanced degradation of organics, but also favors a high product yield and quality. Various TSBRs have been developed for the production of methane, hydrogen, electricity, bioplastics, bioflocculants, biopesticides, biosurfactants and other value-added products, demonstrating marked advantages over the conventional one-stage processes. It represents a promising, and likely the sole viable, paradigm for future application. However, there are also many remaining challenges. This paper provides an overview of the various TSBPs, introduces the recent advances, and discusses the major challenges and the future perspectives for practical application. PMID:21884782

  11. Discrete blasts in granular material yield two-stage process of cavitation and granular fountaining

    NASA Astrophysics Data System (ADS)

    Andrews, Robin; White, James; Dürig, Tobi; Zimanowski, Bernd

    2014-05-01

    A discrete blast within granular material, such as a single subterranean explosion within a debris-filled diatreme structure, is typically considered to produce a single uprush of material. Our experiments demonstrate that apparent "debris jet deposits" can be formed by a two-stage process of cavitation and subsequent granular fountaining. Bench-scale experiments reported here demonstrate that for a range of overpressures and depths, individual, discrete, buried gas blasts open space and expel particles from the blast site in two largely decoupled stages. Expanding gas initially pierces material nearest the blast source to open a cavity above it; then a fountain of grains rises from the source into the cavity. This staged motion dynamically segregates source grains from host-material grains, and the rates of cavity opening vs. fountain rise show a power-law decay relationship with initial pressure. Our experimental analysis has implications for maar-diatreme systems, field-scale detonation experiments, and underground nuclear testing.

  12. Discrete blasts in granular material yield two-stage process of cavitation and granular fountaining

    NASA Astrophysics Data System (ADS)

    Andrews, Robin G.; White, James D. L.; Dürig, Tobi; Zimanowski, Bernd

    2014-01-01

    A discrete blast within granular material, such as a single subterranean explosion within a debris-filled diatreme structure, is typically considered to produce a single uprush of material. Our experiments demonstrate that apparent "debris jet deposits" can be formed by a two-stage process of cavitation and subsequent granular fountaining. Bench-scale experiments reported here demonstrate that for a range of overpressures and depths, individual, discrete, buried gas blasts open space and expel particles from the blast site in two largely decoupled stages. Expanding gas initially pierces material nearest the blast source to open a cavity above it; then a fountain of grains rises from the source into the cavity. This staged motion dynamically segregates source grains from host-material grains, and the rates of cavity opening versus fountain rise show a power law decay relationship with initial pressure. Our experimental analysis has implications for maar-diatreme systems, field-scale detonation experiments, and underground nuclear testing.

  13. Joining advanced materials into hybrid structures using pressurized combustion synthesis

    SciTech Connect

    Messler, R.W. Jr.; Orling, T.T.

    1994-12-31

    Demanding design requirements frequently call for the use and joining of combinations of oxide and nonoxide ceramics, intermetallics, and metals in virtually every imaginable combination in both monolithic and reinforced forms, resulting in hybrid structures. Such new, nontraditional materials and structures can be expected to require new, nontraditional joining processes. One attractive, but embryonic option, is pressurized combustion synthesis, a form of exothermic welding or brazing. Pressurized combustion synthesis or self-propagating high-temperature synthesis (SHS) joining is being systematically studied to understand the mechanism(s) of joint formation, understand the role of processing parameters, evaluate and optimize joint properties, and develop a process model for use in joint design, parameter selection, property prediction, and intelligent process control. This paper presents the results of a study on a model system of 3Ni + Al > Ni{sub 3}Al filler or intermediate between nickel-base superalloy end elements. A Gleeble thermal-mechanical simulator was used to investigate the effects of reaction temperature, hold time, applied pressure, reactant composition, and heating rate, and good insight has been gained to enable more intensive studies of process fundamentals and of techniques for producing more complex, functional gradient material (FGM) joints between dissimilar combinations of ceramics, intermetallics and metals.

  14. Advanced high-temperature, high-pressure transport reactor gasification

    SciTech Connect

    Swanson, M.L.

    1999-07-01

    The mission of the U.S. Department of Energy's (DOE's) Federal Energy Technology Center Office of Power Systems Product Management is to foster the development and deployment of advanced, clean, and affordable fossil-based (coal) power systems. These advanced power systems include the development and demonstration of gasification-based advanced power systems. These systems are integral parts of the Vision 21 Program for the co-production of power and chemicals which is being developed at DOE. DOE has been developing advanced gasification systems which lower the capital and operating cost of producing syngas for electricity or chemicals production. A transport reactor gasifier has shown potential to be a low-cost syngas producer as compared to other gasification systems because of its high throughput. This work directly supports the Power Systems Development Facility (PSDF) utilizing the Kellogg, Brown and Root (KBR) transport reactor located at the Southern Company Services (SCS) Wilsonville, Alabama, site. Over 1000 hours of operation on three different fuels in the pilot-scale transport reactor development unit (TRDU) has been completed to date. The Energy and Environmental Research Center (EERC) has established an extensive database on the operation of various fuels in a transport reactor gasifier. This database will be useful in determining the effectiveness of design changes on a transport reactor gasifier. It has been demonstrated that corrected fuel gas heating values ranging between 105 to 130 Btu/scf can be achieved. Factors that affect the TRDU product gas quality appear to be circulation rate, coal type, temperature, and air:coal and steam:coal ratios. Future plans are to modify the transport reactor mixing zone and J-leg loop seal to increase backmixing, thereby increasing solids residence time and gasifier performance. Enriched air- and oxygen-blown gasification tests, especially on widely available low-cost fuels such as petroleum coke, will also be

  15. Residential oil burners with low input and two-stage firing

    SciTech Connect

    Butcher, T.A.; Leigh, R.; Krajewski, R.; Celebi, Y.; Fisher, L.; Kamath, B.

    1997-12-31

    The residential oil burner market is currently dominated by the pressure-atomized retention head burner. At low firing rates, pressure-atomizing nozzles suffer rapid fouling of the small internal passages, leading to bad spray patterns and poor combustion performance. To overcome the low input limitations of conventional burners, a low-pressure air-atomized burner has been developed that can operate at firing rates, as low as 0.25 gallons of oil per hour (10 kW). In addition, the burner can be operated in a high/low firing rate mode. Field tests with this burner have been conducted at a fixed input rate of 0.35 gph (14 kW) with a sidewall vented boiler/water storage tank combination. At the test home, instrumentation was installed to measure fuel and energy flows and record trends in system temperatures. Laboratory efficiency testing with water heaters and boilers has been completed using standard single-purpose and combined appliance test procedures. The tests quantify benefits due to low firing rates and other burner features. A two-stage oil burner gains a strong advantage in rated efficiency while maintaining capacity for high domestic hot water and space-heating loads.

  16. A gas-loading system for LANL two-stage gas guns

    SciTech Connect

    Gibson, Lloyd Lee; Bartram, Brian Douglas; Dattelbaum, Dana Mcgraw; Lang, John Michael; Morris, John Scott

    2015-09-01

    A novel gas loading system was designed for the specific application of remotely loading high purity gases into targets for gas-gun driven plate impact experiments. The high purity gases are loaded into well-defined target configurations to obtain Hugoniot states in the gas phase at greater than ambient pressures.The small volume of the gas samples is challenging, as slight changing in the ambient temperature result in measurable pressure changes. Therefore, the ability to load a gas gun target and continually monitor the sample pressure prior to firing provides the most stable and reliable target fielding approach. We present the design and evaluation of a gas loading system built for the LANL 50 mm bore two-stage light gas gun. Targets for the gun are made of 6061 Al or OFHC Cu, and assembled to form a gas containment cell with a volume of approximately 1.38 cc. The compatibility of materials was a major consideration in the design of the system, particularly for its use with corrosive gases. Piping and valves are stainless steel with wetted seals made from Kalrez® and Teflon®. Preliminary testing was completed to ensure proper flow rate and that the proper safety controls were in place. The system has been used to successfully load Ar, Kr, Xe, and anhydrous ammonia with purities of up to 99.999 percent. The design of the system and example data from the plate impact experiments will be shown.

  17. The Mechanism of Phagocytosis: Two Stages of Engulfment

    PubMed Central

    Richards, David M.; Endres, Robert G.

    2014-01-01

    Despite being of vital importance to the immune system, the mechanism by which cells engulf relatively large solid particles during phagocytosis is still poorly understood. From movies of neutrophil phagocytosis of polystyrene beads, we measure the fractional engulfment as a function of time and demonstrate that phagocytosis occurs in two distinct stages. During the first stage, engulfment is relatively slow and progressively slows down as phagocytosis proceeds. However, at approximately half-engulfment, the rate of engulfment increases dramatically, with complete engulfment attained soon afterwards. By studying simple mathematical models of phagocytosis, we suggest that the first stage is due to a passive mechanism, determined by receptor diffusion and capture, whereas the second stage is more actively controlled, perhaps with receptors being driven toward the site of engulfment. We then consider a more advanced model that includes signaling and captures both stages of engulfment. This model predicts that there is an optimum ligand density for quick engulfment. Further, we show how this model explains why nonspherical particles engulf quickest when presented tip-first. Our findings suggest that active regulation may be a later evolutionary innovation, allowing fast and robust engulfment even for large particles. PMID:25296306

  18. The Mechanism of Phagocytosis: Two Stages of Engulfment

    NASA Astrophysics Data System (ADS)

    Richards, David M.; Endres, Robert G.

    2014-10-01

    Despite being of vital importance to the immune system, the mechanism by which cells engulf relatively large solid particles during phagocytosis is still poorly understood. From movies of neutrophil phagocytosis of polystyrene beads, we measure the fractional engulfment as a function of time and demonstrate that phagocytosis occurs in two distinct stages. During the first stage, engulfment is relatively slow and progressively slows down as phagocytosis proceeds. However, at approximately half-engulfment, the rate of engulfment increases dramatically, with complete engulfment attained soon afterwards. By studying simple mathematical models of phagocytosis, we suggest that the first stage is due to a passive mechanism, determined by receptor diffusion and capture, whereas the second stage is more actively controlled, perhaps with receptors being driven towards the site of engulfment. We then consider a more advanced model that includes signaling and captures both stages of engulfment. This model predicts that there is an optimum ligand density for quick engulfment. Further, we show how this model explains why non-spherical particles engulf quickest when presented tip-first. Our findings suggest that active regulation may be a later evolutionary innovation, allowing fast and robust engulfment even for large particles.

  19. Two stages of dust delivery from satellites to planetary rings

    NASA Astrophysics Data System (ADS)

    Dikarev, Valeri V.; Krivov, Alexander V.; Grün, Eberhard

    2006-08-01

    Faint rings of micrometre-sized dust particles embrace many planets in the Solar system. As a rule, they are replenished by ejecta from embedded atmosphereless moons. On a number of occasions, the ejecta are generated by hypervelocity meteoroid impacts into the moons. Small ejecta fragments are then swiftly shifted into rings by an array of non-gravitational forces, e.g. radiation pressure or plasma drag. A significant fraction of ejecta mass, however, is contained in relatively big, multi-micrometre fragments which are subject to gravity only. Having escaped from the satellite, they stay close to its orbit and form a belt around planet. This belt is itself a source of ring dust through collisional disruption of its particles. Here the contributions of belts to the respective rings are estimated for selected satellites of Jupiter and Saturn. The belts under review could supply substantially more dust to rings than the direct ejecta from satellites and should be taken into account when estimating ring dust budgets. The belts are very difficult to observe, however, and some of them remain a theoretical proposition. We find an appealing evidence for the belts due to Amalthea and Thebe around Jupiter, and for the belt due to Enceladus around Saturn.

  20. Advanced High-Temperature, High-Pressure Transport Reactor Gasification

    SciTech Connect

    Michael Swanson; Daniel Laudal

    2008-03-31

    The U.S. Department of Energy (DOE) National Energy Technology Laboratory Office of Coal and Environmental Systems has as its mission to develop advanced gasification-based technologies for affordable, efficient, zero-emission power generation. These advanced power systems, which are expected to produce near-zero pollutants, are an integral part of DOE's Vision 21 Program. DOE has also been developing advanced gasification systems that lower the capital and operating costs of producing syngas for chemical production. A transport reactor has shown potential to be a low-cost syngas producer compared to other gasification systems since its high-throughput-per-unit cross-sectional area reduces capital costs. This work directly supports the Power Systems Development Facility utilizing the KBR transport reactor located at the Southern Company Services Wilsonville, Alabama, site. Over 2800 hours of operation on 11 different coals ranging from bituminous to lignite along with a petroleum coke has been completed to date in the pilot-scale transport reactor development unit (TRDU) at the Energy & Environmental Research Center (EERC). The EERC has established an extensive database on the operation of these various fuels in both air-blown and oxygen-blown modes utilizing a pilot-scale transport reactor gasifier. This database has been useful in determining the effectiveness of design changes on an advanced transport reactor gasifier and for determining the performance of various feedstocks in a transport reactor. The effects of different fuel types on both gasifier performance and the operation of the hot-gas filter system have been determined. It has been demonstrated that corrected fuel gas heating values ranging from 90 to 130 Btu/scf have been achieved in air-blown mode, while heating values up to 230 Btu/scf on a dry basis have been achieved in oxygen-blown mode. Carbon conversions up to 95% have also been obtained and are highly dependent on the oxygen-coal ratio. Higher

  1. Removed antibiotic-impregnated cement spacers in two-stage revision joint arthroplasty do not show biofilm formation in vivo.

    PubMed

    Griffin, Justin W; Guillot, Stacey J; Redick, Jan A; Browne, James A

    2012-12-01

    Use of antibiotic-impregnated spacers is common in the two-stage approach to treatment of periprosthetic joint infection despite the lack of information regarding in vivo performance of these implants. Antibiotic elution levels likely often fall below the minimal inhibitory concentration need to inhibit bacterial growth, raising concern that the spacers themselves may provide a potential attachment site for biofilm formation. Advanced microscopy was used in this study to evaluate the surface characteristics of antibiotic-eluting spacers collected at the time of prosthesis reimplantation from 6 patients undergoing two-stage treatment for an infected total joint arthroplasty. Scanning electron microscopy and confocal scanning microscopy of the removed spacers revealed modest fibrous matrix formation and inflammatory cells with no biofilm or bacteria detected. This study supports the continued use of antibiotic spacers in the treatment of periprosthetic joint infection.

  2. Optimization Study of the Ames 0.5 Two-Stage Light Gas Gun

    NASA Technical Reports Server (NTRS)

    Bogdanoff, D. W.

    1996-01-01

    There is a need for more faithful simulation of space debris impacts on various space vehicles. Space debris impact velocities can range up to 14 km/sec and conventional two-stage light gas guns with moderately heavy saboted projectiles are limited to launch velocities of 7-8 km/sec. Any increases obtained in the launch velocities will result in more faithful simulations of debris impacts. It would also be valuable to reduce the maximum gun and projectile base pressures and the gun barrel erosion rate. In this paper, the results of a computational fluid dynamics (CFD) study designed to optimize the performance of the NASA Ames 0.5' gun by systematically varying seven gun operating parameters are reported. Particularly beneficial effects were predicted to occur if (1) the piston mass was decreased together with the powder mass and the hydrogen fill pressure and (2) the pump tube length was decreased. The optimum set of changes in gun operating conditions were predicted to produce an increase in muzzle velocity of 0.7-1.0 km/sec, simultaneously with a substantial decrease in gun erosion. Preliminary experimental data have validated the code predictions. Velocities of up to 8.2 km/sec with a 0.475 cm diameter saboted aluminum sphere have been obtained, along with large reductions in gun erosion rates.

  3. CFD Modelling of Bore Erosion in Two-Stage Light Gas Guns

    NASA Technical Reports Server (NTRS)

    Bogdanoff, D. W.

    1998-01-01

    A well-validated quasi-one-dimensional computational fluid dynamics (CFD) code for the analysis of the internal ballistics of two-stage light gas guns is modified to explicitly calculate the ablation of steel from the gun bore and the incorporation of the ablated wall material into the hydrogen working cas. The modified code is used to model 45 shots made with the NASA Ames 0.5 inch light gas gun over an extremely wide variety of gun operating conditions. Good agreement is found between the experimental and theoretical piston velocities (maximum errors of +/-2% to +/-6%) and maximum powder pressures (maximum errors of +/-10% with good igniters). Overall, the agreement between the experimental and numerically calculated gun erosion values (within a factor of 2) was judged to be reasonably good, considering the complexity of the processes modelled. Experimental muzzle velocities agree very well (maximum errors of 0.5-0.7 km/sec) with theoretical muzzle velocities calculated with loading of the hydrogen gas with the ablated barrel wall material. Comparison of results for pump tube volumes of 100%, 60% and 40% of an initial benchmark value show that, at the higher muzzle velocities, operation at 40% pump tube volume produces much lower hydrogen loading and gun erosion and substantially lower maximum pressures in the gun. Large muzzle velocity gains (2.4-5.4 km/sec) are predicted upon driving the gun harder (that is, upon using, higher powder loads and/or lower hydrogen fill pressures) when hydrogen loading is neglected; much smaller muzzle velocity gains (1.1-2.2 km/sec) are predicted when hydrogen loading is taken into account. These smaller predicted velocity gains agree well with those achieved in practice. CFD snapshots of the hydrogen mass fraction, density and pressure of the in-bore medium are presented for a very erosive shot.

  4. Optics of two-stage photovoltaic concentrators with dielectric second stages.

    PubMed

    Ning, X; O'Gallagher, J; Winston, R

    1987-04-01

    Two-stage photovoltaic concentrators with Fresnel lenses as primaries and dielectric totally internally reflecting nonimaging concentrators as secondaries are discussed. The general design principles of such two-stage systems are given. Their optical properties are studied and analyzed in detail using computer ray trace procedures. It is found that the two-stage concentrator offers not only a higher concentration or increased acceptance angle, but also a more uniform flux distribution on the photovoltaic cell than the point focusing Fresnel lens alone. Experimental measurements with a two-stage prototype module are presented and compared to the analytical predictions. PMID:20454302

  5. Advanced High-Temperature, High-Pressure Transport Reactor Gasification

    SciTech Connect

    Michael L. Swanson

    2005-08-30

    50 hours of gasification on a petroleum coke from the Hunt Oil Refinery and an additional 73 hours of operation on a high-ash coal from India. Data from these tests indicate that while acceptable fuel gas heating value was achieved with these fuels, the transport gasifier performs better on the lower-rank feedstocks because of their higher char reactivity. Comparable carbon conversions have been achieved at similar oxygen/coal ratios for both air-blown and oxygen-blown operation for each fuel; however, carbon conversion was lower for the less reactive feedstocks. While separation of fines from the feed coals is not needed with this technology, some testing has suggested that feedstocks with higher levels of fines have resulted in reduced carbon conversion, presumably due to the inability of the finer carbon particles to be captured by the cyclones. These data show that these low-rank feedstocks provided similar fuel gas heating values; however, even among the high-reactivity low-rank coals, the carbon conversion did appear to be lower for the fuels (brown coal in particular) that contained a significant amount of fines. The fuel gas under oxygen-blown operation has been higher in hydrogen and carbon dioxide concentration since the higher steam injection rate promotes the water-gas shift reaction to produce more CO{sub 2} and H{sub 2} at the expense of the CO and water vapor. However, the high water and CO{sub 2} partial pressures have also significantly reduced the reaction of (Abstract truncated)

  6. Recent advances in lightweight, filament-wound composite pressure vessel technology

    NASA Technical Reports Server (NTRS)

    Lark, R. F.

    1977-01-01

    A review of recent advances is presented for lightweight, high performance composite pressure vessel technology that covers the areas of design concepts, fabrication procedures, applications, and performance of vessels subjected to single cycle burst and cyclic fatigue loading. Filament wound fiber/epoxy composite vessels were made from S glass, graphite, and Kevlar 49 fibers and were equipped with both structural and nonstructural liners. Pressure vessels structural efficiencies were attained which represented weight savings, using different liners, of 40 to 60 percent over all titanium pressure vessels. Significant findings in each area are summarized.

  7. Experimental Investigation of a Model of a Two-Stage Turboblower

    NASA Technical Reports Server (NTRS)

    Dovjik, s.; Polikovsky, W.

    1943-01-01

    In the present paper an investigation is made of two stages of a multistage turboblower having a vaneless diffuser behind the impeller and guide vanes at the inlet to the nest stage. The method employed was that of investigating the performance of the successive elements of the blower (the impeller, vaneless diffuser, ets.) whereby the kinematics of the flow through the blower could be followed and the pressure at the different points computed. The character of the flow and the physical significance of the loss coefficients could thereby be determined so as to secure the best agreement of the computed with the actual performance of the blower. Since the tests were carried out for various delivery volumes, the dependence of the coefficients on a number of factors (angle of attack, velocities, etc.) could be obtained. The distribution of the losses that occur during the transformation of dynamic pressure at the impeller exit into static pressure could be found and likewise the range within which the friction coefficient varies in the vaneless diffuser. With the aid of factors having a certain physical significance, the centrifugal blower could be computed on the basis of a more or less schematical consideration of the phenomena occuring during the air flow through it, and the use of arbitrary factors and recourse to the geometrical similtude law thus avoided. The present investigation largely summarizes all the previous work af the CHI Blower Section on the different elements of a centrifugal blower. Some considerations on the analysis of model test data for application to full-scale are presented in the appendix.

  8. Advanced Computational Thermal Studies and their Assessment for Supercritical-Pressure Reactors (SCRs)

    SciTech Connect

    D. M. McEligot; J. Y. Yoo; J. S. Lee; S. T. Ro; E. Lurien; S. O. Park; R. H. Pletcher; B. L. Smith; P. Vukoslavcevic; J. M. Wallace

    2009-04-01

    The goal of this laboratory / university collaboration of coupled computational and experimental studies is the improvement of predictive methods for supercritical-pressure reactors. The general objective is to develop supporting knowledge needed of advanced computational techniques for the technology development of the concepts and their safety systems.

  9. Electric and hybrid electric vehicles: A technology assessment based on a two-stage Delphi study

    SciTech Connect

    Vyas, A.D.; Ng, H.K.; Santini, D.J.; Anderson, J.L.

    1997-12-01

    To address the uncertainty regarding future costs and operating attributes of electric and hybrid electric vehicles, a two stage, worldwide Delphi study was conducted. Expert opinions on vehicle attributes, current state of the technology, possible advancements, costs, and market penetration potential were sought for the years 2000, 2010, and 2020. Opinions related to such critical components as batteries, electric drive systems, and hybrid vehicle engines, as well as their respective technical and economic viabilities, were also obtained. This report contains descriptions of the survey methodology, analytical approach, and results of the analysis of survey data, together with a summary of other factors that will influence the degree of market success of electric and hybrid electric vehicle technologies. Responses by industry participants, the largest fraction among all the participating groups, are compared with the overall responses. An evaluation of changes between the two Delphi stages is also summarized. An analysis of battery replacement costs for various types is summarized, and variable operating costs for electric and hybrid vehicles are compared with those of conventional vehicles. A market penetration analysis is summarized, in which projected market shares from the survey are compared with predictions of shares on the basis of two market share projection models that use the cost and physical attributes provided by the survey. Finally, projections of market shares beyond the year 2020 are developed by use of constrained logit models of market shares, statistically fitted to the survey data.

  10. Development of a Two-Stage Mars Ascent Vehicle Using In-Situ Propellant Production

    NASA Technical Reports Server (NTRS)

    Paxton, Laurel; Vaughan, David

    2014-01-01

    Mars Sample Return (MSR) and Mars In-Situ Resource Utilization (ISRU) present two main challenges for the advancement of Mars science. MSR would demonstrate Mars lift-off capability, while ISRU would test the ability to produce fuel and oxidizer using Martian resources, a crucial step for future human missions. A two-stage Mars Ascent Vehicle (MAV) concept was developed to support sample return as well as in-situ propellant production. The MAV would be powered by a solid rocket first stage and a LOX-propane second stage. A liquid second-stage provides higher orbit insertion reliability than a solid second stage as well as a degree of complexity eventually required for manned missions. Propane in particular offers comparable performance to methane without requiring cryogenic storage. The total MAV mass would be 119.9 kg to carry an 11 kg payload to orbit. The feasibility of in-situ fuel and oxidizer production was also examined. Two potential schemes were evaluated for production capability, size and power requirements. The schemes examined utilize CO2 and water as starting blocks to produce LOX and a propane blend. The infrastructure required to fuel and launch the MAV was also explored.

  11. Two-stage seasonal streamflow forecasts to guide water resources decisions and water rights allocation

    NASA Astrophysics Data System (ADS)

    Block, P. J.; Gonzalez, E.; Bonnafous, L.

    2011-12-01

    Decision-making in water resources is inherently uncertain producing copious risks, ranging from operational (present) to planning (season-ahead) to design/adaptation (decadal) time-scales. These risks include human activity and climate variability/change. As the risks in designing and operating water systems and allocating available supplies vary systematically in time, prospects for predicting and managing such risks become increasingly attractive. Considerable effort has been undertaken to improve seasonal forecast skill and advocate for integration to reduce risk, however only minimal adoption is evident. Impediments are well defined, yet tailoring forecast products and allowing for flexible adoption assist in overcoming some obstacles. The semi-arid Elqui River basin in Chile is contending with increasing levels of water stress and demand coupled with insufficient investment in infrastructure, taxing its ability to meet agriculture, hydropower, and environmental requirements. The basin is fed from a retreating glacier, with allocation principles founded on a system of water rights and markets. A two-stage seasonal streamflow forecast at leads of one and two seasons prescribes the probability of reductions in the value of each water right, allowing water managers to inform their constituents in advance. A tool linking the streamflow forecast to a simple reservoir decision model also allows water managers to select a level of confidence in the forecast information.

  12. Removal of cesium from simulated liquid waste with countercurrent two-stage adsorption followed by microfiltration.

    PubMed

    Han, Fei; Zhang, Guang-Hui; Gu, Ping

    2012-07-30

    Copper ferrocyanide (CuFC) was used as an adsorbent to remove cesium. Jar test results showed that the adsorption capacity of CuFC was better than that of potassium zinc hexacyanoferrate. Lab-scale tests were performed by an adsorption-microfiltration process, and the mean decontamination factor (DF) was 463 when the initial cesium concentration was 101.3μg/L, the dosage of CuFC was 40mg/L and the adsorption time was 20min. The cesium concentration in the effluent continuously decreased with the operation time, which indicated that the used adsorbent retained its adsorption capacity. To use this capacity, experiments on a countercurrent two-stage adsorption (CTA)-microfiltration (MF) process were carried out with CuFC adsorption combined with membrane separation. A calculation method for determining the cesium concentration in the effluent was given, and batch tests in a pressure cup were performed to verify the calculated method. The results showed that the experimental values fitted well with the calculated values in the CTA-MF process. The mean DF was 1123 when the dilution factor was 0.4, the initial cesium concentration was 98.75μg/L and the dosage of CuFC and adsorption time were the same as those used in the lab-scale test. The DF obtained by CTA-MF process was more than three times higher than the single-stage adsorption in the jar test.

  13. New higher-order Godunov code for modelling performance of two-stage light gas guns

    NASA Technical Reports Server (NTRS)

    Bogdanoff, D. W.; Miller, R. J.

    1995-01-01

    A new quasi-one-dimensional Godunov code for modeling two-stage light gas guns is described. The code is third-order accurate in space and second-order accurate in time. A very accurate Riemann solver is used. Friction and heat transfer to the tube wall for gases and dense media are modeled and a simple nonequilibrium turbulence model is used for gas flows. The code also models gunpowder burn in the first-stage breech. Realistic equations of state (EOS) are used for all media. The code was validated against exact solutions of Riemann's shock-tube problem, impact of dense media slabs at velocities up to 20 km/sec, flow through a supersonic convergent-divergent nozzle and burning of gunpowder in a closed bomb. Excellent validation results were obtained. The code was then used to predict the performance of two light gas guns (1.5 in. and 0.28 in.) in service at the Ames Research Center. The code predictions were compared with measured pressure histories in the powder chamber and pump tube and with measured piston and projectile velocities. Very good agreement between computational fluid dynamics (CFD) predictions and measurements was obtained. Actual powder-burn rates in the gun were found to be considerably higher (60-90 percent) than predicted by the manufacturer and the behavior of the piston upon yielding appears to differ greatly from that suggested by low-strain rate tests.

  14. Two-stage fan. 4: Performance data for stator setting angle optimization

    NASA Technical Reports Server (NTRS)

    Burger, G. D.; Keenan, M. J.

    1975-01-01

    Stator setting angle optimization tests were conducted on a two-stage fan to improve efficiency at overspeed, stall margin at design speed, and both efficiency and stall margin at partspeed. The fan has a design pressure ratio of 2.8, a flow rate of 184.2 lb/sec (83.55 kg/sec) and a 1st-stage rotor tip speed of 1450 ft/sec (441.96 in/sec). Performance was obtained at 70,100, and 105 percent of design speed with different combinations of 1st-stage and 2nd-stage stator settings. One combination of settings, other than design, was common to all three speeds. At design speed, a 2.0 percentage point increase in stall margin was obtained at the expense of a 1.3 percentage point efficiency decrease. At 105 percent speed, efficiency was improved by 1.8 percentage points but stall margin decreased 4.7 percentage points. At 70 percent speed, no change in stall margin or operating line efficiency was obtained with stator resets although considerable speed-flow requlation occurred.

  15. Catalytic two-stage coal hydrogenation process using extinction recycle of heavy liquid fraction

    DOEpatents

    MacArthur, James B.; Comolli, Alfred G.; McLean, Joseph B.

    1989-01-01

    A process for catalytic two-stage hydrogenation and liquefaction of coal with selective extinction recycle of all heavy liquid fractions boiling above a distillation cut point of about 600.degree.-750.degree. F. to produce increased yields of low-boiling hydrocarbon liquid and gas products. In the process, the particulate coal feed is slurried with a process-derived liquid solvent normally boiling above about 650.degree. F. and fed into a first stage catalytic reaction zone operated at conditions which promote controlled rate liquefaction of the coal, while simultaneously hydrogenating the hydrocarbon recycle oils. The first stage reactor is maintained at 710.degree.-800.degree. F. temperature, 1000-4000 psig hydrogen partial pressure, and 10-90 lb/hr per ft.sup.3 catalyst space velocity. Partially hydrogenated material withdrawn from the first stage reaction zone is passed directly to the second stage catalytic reaction zone maintained at 760.degree.-860.degree. F. temperature for further hydrogenation and hydroconversion reactions. A 600.degree.-750.degree. F..sup.+ fraction containing 0-20 W % unreacted coal and ash solids is recycled to the coal slurrying step. If desired, the cut point lower boiling fraction can be further catalytically hydrotreated. By this process, the coal feed is successively catalytically hydrogenated and hydroconverted at selected conditions, to provide significantly increased yields of desirable low-boiling hydrocarbon liquid products and minimal production of hydrocarbon gases, and no net production of undesirable heavy oils and residuum materials.

  16. Catalytic two-stage coal hydrogenation process using extinction recycle of heavy liquid fraction

    DOEpatents

    MacArthur, J.B.; Comolli, A.G.; McLean, J.B.

    1989-10-17

    A process is described for catalytic two-stage hydrogenation and liquefaction of coal with selective extinction recycle of all heavy liquid fractions boiling above a distillation cut point of about 600--750 F to produce increased yields of low-boiling hydrocarbon liquid and gas products. In the process, the particulate coal feed is slurried with a process-derived liquid solvent normally boiling above about 650 F and fed into a first stage catalytic reaction zone operated at conditions which promote controlled rate liquefaction of the coal, while simultaneously hydrogenating the hydrocarbon recycle oils. The first stage reactor is maintained at 710--800 F temperature, 1,000--4,000 psig hydrogen partial pressure, and 10-90 lb/hr per ft[sup 3] catalyst space velocity. Partially hydrogenated material withdrawn from the first stage reaction zone is passed directly to the second stage catalytic reaction zone maintained at 760--860 F temperature for further hydrogenation and hydroconversion reactions. A 600--750 F[sup +] fraction containing 0--20 W % unreacted coal and ash solids is recycled to the coal slurrying step. If desired, the cut point lower boiling fraction can be further catalytically hydrotreated. By this process, the coal feed is successively catalytically hydrogenated and hydroconverted at selected conditions, to provide significantly increased yields of desirable low-boiling hydrocarbon liquid products and minimal production of hydrocarbon gases, and no net production of undesirable heavy oils and residuum materials. 2 figs.

  17. A two-stage, phase-coherent, harmonic-multiplying, inverted gyrotwystron

    NASA Astrophysics Data System (ADS)

    Chen, Shiaw-Huei

    Theory, design, and stable operation of a novel, high- power millimeter wave source, the phase-coherent harmonic-multiplying inverted gyrotwystron (phigtron), are presented. It is a two-stage hybrid gyrodevice which comprises an input waveguide section for fundamental gyro-TWT interaction to prebunch the beam, a radiation- free drift section to rapidly develop the harmonic components in the beam current by ballistic bunching, and a RF energy-extraction output cavity with a number of well selected axial modes resonating at the second harmonic of the input frequency. A large value of the gain-bandwidth product is achieved by using an input section composed of a traveling wave interaction circuit and a long extended interaction structure for the output section. Stable operation of the phigtron may be due in part to operating the input section at half the output frequency and in a relatively low order mode, and in part to employing a mode selective circuit as an input coupler and at each interaction stage to suppress competing modes. In chapter 1, motivation and general description of the phigtron are introduced. The physical mechanism and general formulation for the two-stage phigtron is presented in chapter 2. The engineering design and experimental setup are discussed in chapter 3. Chapter 4 presents the experimental results of the phigtron and simulations. Experiments demonstrated that the phigtron can be operated either as a phase-locked oscillator or a frequency-doubling amplifier. In the case of phase-locked oscillator with the TE02 mode in the input section and TE03 mode in the output cavity, widest bandwidth operation at 34.6 GHz gives 8 MHz bandwidth, 110 kW output power, 30 dB gain and 30% efficiency. A highly overmoded, high gain, broadband, stable amplification was observed with the TE22 mode in the input section and the TE42 mode in the output cavity; bandwidth was 1.3% with saturated gain of 33 dB around 31.8 GHz. The measured gain-bandwidth performance

  18. Adaptive Urban Stormwater Management Using a Two-stage Stochastic Optimization Model

    NASA Astrophysics Data System (ADS)

    Hung, F.; Hobbs, B. F.; McGarity, A. E.

    2014-12-01

    In many older cities, stormwater results in combined sewer overflows (CSOs) and consequent water quality impairments. Because of the expense of traditional approaches for controlling CSOs, cities are considering the use of green infrastructure (GI) to reduce runoff and pollutants. Examples of GI include tree trenches, rain gardens, green roofs, and rain barrels. However, the cost and effectiveness of GI are uncertain, especially at the watershed scale. We present a two-stage stochastic extension of the Stormwater Investment Strategy Evaluation (StormWISE) model (A. McGarity, JWRPM, 2012, 111-24) to explicitly model and optimize these uncertainties in an adaptive management framework. A two-stage model represents the immediate commitment of resources ("here & now") followed by later investment and adaptation decisions ("wait & see"). A case study is presented for Philadelphia, which intends to extensively deploy GI over the next two decades (PWD, "Green City, Clean Water - Implementation and Adaptive Management Plan," 2011). After first-stage decisions are made, the model updates the stochastic objective and constraints (learning). We model two types of "learning" about GI cost and performance. One assumes that learning occurs over time, is automatic, and does not depend on what has been done in stage one (basic model). The other considers learning resulting from active experimentation and learning-by-doing (advanced model). Both require expert probability elicitations, and learning from research and monitoring is modelled by Bayesian updating (as in S. Jacobi et al., JWRPM, 2013, 534-43). The model allocates limited financial resources to GI investments over time to achieve multiple objectives with a given reliability. Objectives include minimizing construction and O&M costs; achieving nutrient, sediment, and runoff volume targets; and community concerns, such as aesthetics, CO2 emissions, heat islands, and recreational values. CVaR (Conditional Value at Risk) and

  19. Two-stage plasma gun based on a gas discharge with a self-heating hollow emitter.

    PubMed

    Vizir, A V; Tyunkov, A V; Shandrikov, M V; Oks, E M

    2010-02-01

    The paper presents the results of tests of a new compact two-stage bulk gas plasma gun. The plasma gun is based on a nonself-sustained gas discharge with an electron emitter based on a discharge with a self-heating hollow cathode. The operating characteristics of the plasma gun are investigated. The discharge system makes it possible to produce uniform and stable gas plasma in the dc mode with a plasma density up to 3x10(9) cm(-3) at an operating gas pressure in the vacuum chamber of less than 2x10(-2) Pa. The device features high power efficiency, design simplicity, and compactness.

  20. Advanced Pressurized Water Reactor for Improved Resource Utilization: Part I - Survey of Potential Improvements

    SciTech Connect

    Turner, S.E.; Gurley, M.K.; Kirby, K.D.; Mitchell, W. III

    1981-09-15

    This document is an interim report under ACDA BOA AC9NX707, Task Order 80-03, which covers the evaluation of certain potential improvements in pressurized water reactor designs intended to enhance uranium fuel utilization. The objective of these evaluations is to seek advanced, non-retrofittable improvements that could possibly be commercialized by the end of the century, and, on the basis of a preliminary evaluation, to select compatible improvements for incorporation into a composite advanced pressurized water reactor concept. The principal areas of investigation include reduced parasitic absorption of neutrons (Task 1), reduced neutron leakage (Task 2), and alternative fuel design concepts (Task 3). To the extent possible, the advanced concept developed in an earlier study (Retrofittable Modifications to Pressurized Water Reactors for Improved Resource Utilization, SSA-128, October 1980) is used as a basis in developing the advanced composite concept. The reference design considered typical of present PWR commercial practice is the system described in RESAR-414, Reference Safety Analysis Report, Westinghouse Nuclear Energy Systems, October 1976.

  1. DEVELOPMENT OF COLD CLIMATE HEAT PUMP USING TWO-STAGE COMPRESSION

    SciTech Connect

    Shen, Bo; Rice, C Keith; Abdelaziz, Omar; Shrestha, Som S

    2015-01-01

    This paper uses a well-regarded, hardware based heat pump system model to investigate a two-stage economizing cycle for cold climate heat pump applications. The two-stage compression cycle has two variable-speed compressors. The high stage compressor was modelled using a compressor map, and the low stage compressor was experimentally studied using calorimeter testing. A single-stage heat pump system was modelled as the baseline. The system performance predictions are compared between the two-stage and single-stage systems. Special considerations for designing a cold climate heat pump are addressed at both the system and component levels.

  2. Design considerations for single-stage and two-stage pneumatic pellet injectors

    SciTech Connect

    Gouge, M.J.; Combs, S.K.; Fisher, P.W.; Milora, S.L.

    1988-09-01

    Performance of single-stage pneumatic pellet injectors is compared with several models for one-dimensional, compressible fluid flow. Agreement is quite good for models that reflect actual breech chamber geometry and incorporate nonideal effects such as gas friction. Several methods of improving the performance of single-stage pneumatic pellet injectors in the near term are outlined. The design and performance of two-stage pneumatic pellet injectors are discussed, and initial data from the two-stage pneumatic pellet injector test facility at Oak Ridge National Laboratory are presented. Finally, a concept for a repeating two-stage pneumatic pellet injector is described. 27 refs., 8 figs., 3 tabs.

  3. Numerical analysis of flow interaction of turbine system in two-stage turbocharger of internal combustion engine

    NASA Astrophysics Data System (ADS)

    Liu, Y. B.; Zhuge, W. L.; Zhang, Y. J.; Zhang, S. Y.

    2016-05-01

    To reach the goal of energy conservation and emission reduction, high intake pressure is needed to meet the demand of high power density and high EGR rate for internal combustion engine. Present power density of diesel engine has reached 90KW/L and intake pressure ratio needed is over 5. Two-stage turbocharging system is an effective way to realize high compression ratio. Because turbocharging system compression work derives from exhaust gas energy. Efficiency of exhaust gas energy influenced by design and matching of turbine system is important to performance of high supercharging engine. Conventional turbine system is assembled by single-stage turbocharger turbines and turbine matching is based on turbine MAP measured on test rig. Flow between turbine system is assumed uniform and value of outlet physical quantities of turbine are regarded as the same as ambient value. However, there are three-dimension flow field distortion and outlet physical quantities value change which will influence performance of turbine system as were demonstrated by some studies. For engine equipped with two-stage turbocharging system, optimization of turbine system design will increase efficiency of exhaust gas energy and thereby increase engine power density. However flow interaction of turbine system will change flow in turbine and influence turbine performance. To recognize the interaction characteristics between high pressure turbine and low pressure turbine, flow in turbine system is modeled and simulated numerically. The calculation results suggested that static pressure field at inlet to low pressure turbine increases back pressure of high pressure turbine, however efficiency of high pressure turbine changes little; distorted velocity field at outlet to high pressure turbine results in swirl at inlet to low pressure turbine. Clockwise swirl results in large negative angle of attack at inlet to rotor which causes flow loss in turbine impeller passages and decreases turbine

  4. Management of severe obstructive sleep apnea using mandibular advancement devices with auto continuous positive airway pressures

    PubMed Central

    Upadhyay, Rashmi; Dubey, Abhishek; Kant, Surya; Singh, Balendra Pratap

    2015-01-01

    The use of continuous positive airway pressures (CPAP) is considered standard treatment of moderate to severe obstructive sleep apnea (OSA). Treatment of the disease poses a great challenge not only for its diagnostic purpose but also for its treatment part. In about 29-83% of the patients, treatment is difficult because of non-compliance resulting due to high pressures, air leaks and other related issues. In such situations, alternative methods of treatment need to be looked for so as to ascertain better management. Mandibular advancement devices along with CPAP may show better treatment outcome in specific situations. PMID:25814802

  5. Neuroscience and approach/avoidance personality traits: a two stage (valuation-motivation) approach.

    PubMed

    Corr, Philip J; McNaughton, Neil

    2012-11-01

    Many personality theories link specific traits to the sensitivities of the neural systems that control approach and avoidance. But there is no consensus on the nature of these systems. Here we combine recent advances in economics and neuroscience to provide a more solid foundation for a neuroscience of approach/avoidance personality. We propose a two-stage integration of valuation (loss/gain) sensitivities with motivational (approach/avoidance/conflict) sensitivities. Our key conclusions are: (1) that valuation of appetitive and aversive events (e.g. gain and loss as studied by behavioural economists) is an independent perceptual input stage--with the economic phenomenon of loss aversion resulting from greater negative valuation sensitivity compared to positive valuation sensitivity; (2) that valuation of an appetitive stimulus then interacts with a contingency of presentation or omission to generate a motivational 'attractor' or 'repulsor', respectively (vice versa for an aversive stimulus); (3) the resultant behavioural tendencies to approach or avoid have distinct sensitivities to those of the valuation systems; (4) while attractors and repulsors can reinforce new responses they also, more usually, elicit innate or previously conditioned responses and so the perception/valuation-motivation/action complex is best characterised as acting as a 'reinforcer' not a 'reinforcement'; and (5) approach-avoidance conflict must be viewed as activating a third motivation system that is distinct from the basic approach and avoidance systems. We provide examples of methods of assessing each of the constructs within approach-avoidance theories and of linking these constructs to personality measures. We sketch a preliminary five-element reinforcer sensitivity theory (RST-5) as a first step in the integration of existing specific approach-avoidance theories into a coherent neuroscience of personality. PMID:23041073

  6. Neuroscience and approach/avoidance personality traits: a two stage (valuation-motivation) approach.

    PubMed

    Corr, Philip J; McNaughton, Neil

    2012-11-01

    Many personality theories link specific traits to the sensitivities of the neural systems that control approach and avoidance. But there is no consensus on the nature of these systems. Here we combine recent advances in economics and neuroscience to provide a more solid foundation for a neuroscience of approach/avoidance personality. We propose a two-stage integration of valuation (loss/gain) sensitivities with motivational (approach/avoidance/conflict) sensitivities. Our key conclusions are: (1) that valuation of appetitive and aversive events (e.g. gain and loss as studied by behavioural economists) is an independent perceptual input stage--with the economic phenomenon of loss aversion resulting from greater negative valuation sensitivity compared to positive valuation sensitivity; (2) that valuation of an appetitive stimulus then interacts with a contingency of presentation or omission to generate a motivational 'attractor' or 'repulsor', respectively (vice versa for an aversive stimulus); (3) the resultant behavioural tendencies to approach or avoid have distinct sensitivities to those of the valuation systems; (4) while attractors and repulsors can reinforce new responses they also, more usually, elicit innate or previously conditioned responses and so the perception/valuation-motivation/action complex is best characterised as acting as a 'reinforcer' not a 'reinforcement'; and (5) approach-avoidance conflict must be viewed as activating a third motivation system that is distinct from the basic approach and avoidance systems. We provide examples of methods of assessing each of the constructs within approach-avoidance theories and of linking these constructs to personality measures. We sketch a preliminary five-element reinforcer sensitivity theory (RST-5) as a first step in the integration of existing specific approach-avoidance theories into a coherent neuroscience of personality.

  7. Microfabrication of a two-stage BioMEMS microfluidic cell sorter

    NASA Astrophysics Data System (ADS)

    Grafton, Meggie M.; Geheb, Benjamin; Jang, Jae Hyuk; Chuang, Han-Sheng; Rajdev, Pooja; Reece, Lisa M.; Irazoqui, Pedro P.; Wereley, Steven T.; Jung, Byunghoo; Leary, James F.

    2009-02-01

    Point-of-care devices represent the future for medical technologies. Current diagnostic tools are cumbersome, expensive, complicated, and often at risk for contamination. There is a need for cost effective, portable, closed-system, high-speed cell screening and cell isolating device. A microfabricated, exponentially-staging, BioMEMS microfluidic cytometer/cell sorting device offers these advantages over current technologies. A two-stage branched architecture allows the study of inter-particle spacing, flow relations, pressure measurements, and cell behavior in an environment where fluorescence detection is used to identify and analyze certain cellular characteristics. This device was microfabricated using the polymer PDMS to transmit light effectively, to be inexpensive and disposable, and to be easy to manipulate. For initial prototyping, an inverted fluorescent Nikon microscope provided the necessary excitation to view the particles and cells. For the portable device, avalanche photo diodes (APDs) and light emitting diodes (LEDs) are being incorporated into the device for the detection and excitation respectively. For low light level applications, sigma-delta modulation methods are being applied to reduce noise susceptibility and to detect the APD signal more efficiently. In addition, a data acquisition system (DAQ) has been designed that can effectively track signals from a cell sorter using a digital signal processing (DSP) board and a laptop computer. Currently elastomeric valves for diverting flow have been incorporated into the microfluidic chip. Measurements are being made of the effects of the microfluidics valve structures, or the simple opening and closing of selected channels to divert flow and cells down specific channels depending on their measured properties.

  8. Investigation on the two-stage active magnetic regenerative refrigerator for liquefaction of hydrogen

    SciTech Connect

    Park, Inmyong; Park, Jiho; Jeong, Sangkwon; Kim, Youngkwon

    2014-01-29

    An active magnetic regenerative refrigerator (AMRR) is expected to be useful for hydrogen liquefaction due to its inherent high thermodynamic efficiency. Because the temperature of the cold end of the refrigerator has to be approximately liquid temperature, a large temperature span of the active magnetic regenerator (AMR) is indispensable when the heat sink temperature is liquid nitrogen temperature or higher. Since magnetic refrigerants are only effective in the vicinity of their own transition temperatures, which limit the temperature span of the AMR, an innovative structure is needed to increase the temperature span. The AMR must be a layered structure and the thermophysical matching of magnetic field and flow convection effects is very important. In order to design an AMR for liquefaction of hydrogen, the implementation of multi-layered AMR with different magnetic refrigerants is explored with multi-staging. In this paper, the performance of the multi-layered AMR using four rare-earth compounds (GdNi{sub 2}, Gd{sub 0.1}Dy{sub 0.9}Ni{sub 2}, Dy{sub 0.85}Er{sub 0.15}Al{sub 2}, Dy{sub 0.5}Er{sub 0.5}Al{sub 2}) is investigated. The experimental apparatus includes two-stage active magnetic regenerator containing two different magnetic refrigerants each. A liquid nitrogen reservoir connected to the warm end of the AMR maintains the temperature of the warm end around 77 K. High-pressure helium gas is employed as a heat transfer fluid in the AMR and the maximum magnetic field of 4 T is supplied by the low temperature superconducting (LTS) magnet. The temperature span with the variation of parameters such as phase difference between magnetic field and mass flow rate of magnetic refrigerants in AMR is investigated. The maximum temperature span in the experiment is recorded as 50 K and several performance issues have been discussed in this paper.

  9. Recent advances in lightweight, filament-wound composite pressure vessel technology

    NASA Technical Reports Server (NTRS)

    Lark, R. F.

    1977-01-01

    A review of recent advances is presented for lightweight, high-performance composite pressure vessel technology that covers the areas of design concepts, fabrication procedures, applications, and performance of vessels subjected to single-cycle burst and cyclic fatigue loading. Filament-wound fiber/epoxy composite vessels were made from S-glass, graphite, and Kevlar 49 fibers and were equipped with both structural and nonstructural liners. Pressure vessel structural efficiencies were attained which represented weight savings, using different liners, of 40 to 60 percent over all-titanium pressure vessels. Significant findings in each area are summarized including data from current NASA-Lewis Research Center contractual and in-house programs.

  10. Unsteady blade surface pressures on a large-scale advanced propeller - Prediction and data

    NASA Technical Reports Server (NTRS)

    Nallasamy, M.; Groeneweg, J. F.

    1990-01-01

    An unsteady three dimensional Euler analysis technique is employed to compute the flowfield of an advanced propeller operating at an angle of attack. The predicted blade pressure waveforms are compared with wind tunnel data at two Mach numbers, 0.5 and 0.2. The inflow angle is three degrees. For an inflow Mach number of 0.5, the predicted pressure response is in fair agreement with data: the predicted phases of the waveforms are in close agreement with data while the magnitudes are underpredicted. At the low Mach number of 0.2 (take-off) the numerical solution shows the formation of a leading edge vortex which is in qualitative agreement with measurements. However, the highly nonlinear pressure response measured on the blade suction surface is not captured in the present inviscid analysis.

  11. Unsteady blade-surface pressures on a large-scale advanced propeller: Prediction and data

    NASA Technical Reports Server (NTRS)

    Nallasamy, M.; Groeneweg, J. F.

    1990-01-01

    An unsteady 3-D Euler analysis technique is employed to compute the flow field of an advanced propeller operating at an angle of attack. The predicted blade pressure waveforms are compared with wind tunnel data at two Mach numbers, 0.5 and 0.2. The inflow angle is three degrees. For an inflow Mach number of 0.5, the predicted pressure response is in fair agreement with data: the predicted phases of the waveforms are in close agreement with data while the magnitudes are underpredicted. At the low Mach number of 0.2 (takeoff), the numerical solution shows the formation of a leading edge vortex which is in qualitative agreement with measurements. However, the highly nonlinear pressure response measured on the blade suction surface is not captured in the present inviscid analysis.

  12. Advanced Computational Modeling of Vapor Deposition in a High-Pressure Reactor

    NASA Technical Reports Server (NTRS)

    Cardelino, Beatriz H.; Moore, Craig E.; McCall, Sonya D.; Cardelino, Carlos A.; Dietz, Nikolaus; Bachmann, Klaus

    2004-01-01

    In search of novel approaches to produce new materials for electro-optic technologies, advances have been achieved in the development of computer models for vapor deposition reactors in space. Numerical simulations are invaluable tools for costly and difficult processes, such as those experiments designed for high pressures and microgravity conditions. Indium nitride is a candidate compound for high-speed laser and photo diodes for optical communication system, as well as for semiconductor lasers operating into the blue and ultraviolet regions. But InN and other nitride compounds exhibit large thermal decomposition at its optimum growth temperature. In addition, epitaxy at lower temperatures and subatmospheric pressures incorporates indium droplets into the InN films. However, surface stabilization data indicate that InN could be grown at 900 K in high nitrogen pressures, and microgravity could provide laminar flow conditions. Numerical models for chemical vapor deposition have been developed, coupling complex chemical kinetics with fluid dynamic properties.

  13. Advanced Computational Modeling of Vapor Deposition in a High-pressure Reactor

    NASA Technical Reports Server (NTRS)

    Cardelino, Beatriz H.; Moore, Craig E.; McCall, Sonya D.; Cardelino, Carlos A.; Dietz, Nikolaus; Bachmann, Klaus

    2004-01-01

    In search of novel approaches to produce new materials for electro-optic technologies, advances have been achieved in the development of computer models for vapor deposition reactors in space. Numerical simulations are invaluable tools for costly and difficult processes, such as those experiments designed for high pressures and microgravity conditions. Indium nitride is a candidate compound for high-speed laser and photo diodes for optical communication system, as well as for semiconductor lasers operating into the blue and ultraviolet regions. But InN and other nitride compounds exhibit large thermal decomposition at its optimum growth temperature. In addition, epitaxy at lower temperatures and subatmospheric pressures incorporates indium droplets into the InN films. However, surface stabilization data indicate that InN could be grown at 900 K in high nitrogen pressures, and microgravity could provide laminar flow conditions. Numerical models for chemical vapor deposition have been developed, coupling complex chemical kinetics with fluid dynamic properties.

  14. A CFD Analysis of Steam Flow in the Two-Stage Experimental Impulse Turbine with the Drum Rotor Arrangement

    NASA Astrophysics Data System (ADS)

    Yun, Kukchol; Tajč, L.; Kolovratník, M.

    2016-03-01

    The aim of the paper is to present the CFD analysis of the steam flow in the two-stage turbine with a drum rotor and balancing slots. The balancing slot is a part of every rotor blade and it can be used in the same way as balancing holes on the classical rotor disc. The main attention is focused on the explanation of the experimental knowledge about the impact of the slot covering and uncovering on the efficiency of the individual stages and the entire turbine. The pressure and temperature fields and the mass steam flows through the shaft seals, slots and blade cascades are calculated. The impact of the balancing slots covering or uncovering on the reaction and velocity conditions in the stages is evaluated according to the pressure and temperature fields. We have also concentrated on the analysis of the seal steam flow through the balancing slots. The optimized design of the balancing slots has been suggested.

  15. Removal of multiple electron acceptors by pilot-scale, two-stage membrane biofilm reactors.

    PubMed

    Zhao, He-Ping; Ontiveros-Valencia, Aura; Tang, Youneng; Kim, Bi-O; Vanginkel, Steven; Friese, David; Overstreet, Ryan; Smith, Jennifer; Evans, Patrick; Krajmalnik-Brown, Rosa; Rittmann, Bruce

    2014-05-01

    We studied the performance of a pilot-scale membrane biofilm reactor (MBfR) treating groundwater containing four electron acceptors: nitrate (NO3(-)), perchlorate (ClO4(-)), sulfate (SO4(2-)), and oxygen (O2). The treatment goal was to remove ClO4(-) from ∼200 μg/L to less than 6 μg/L. The pilot system was operated as two MBfRs in series, and the positions of the lead and lag MBfRs were switched regularly. The lead MBfR removed at least 99% of the O2 and 63-88% of NO3(-), depending on loading conditions. The lag MBfR was where most of the ClO4(-) reduction occurred, and the effluent ClO4(-) concentration was driven to as low as 4 μg/L, with most concentrations ≤10 μg/L. However, SO4(2-) reduction occurred in the lag MBfR when its NO3(-) + O2 flux was smaller than ∼0.18 g H2/m(2)-d, and this was accompanied by a lower ClO4(-) flux. We were able to suppress SO4(2-) reduction by lowering the H2 pressure and increasing the NO3(-) + O2 flux. We also monitored the microbial community using the quantitative polymerase chain reaction targeting characteristic reductase genes. Due to regular position switching, the lead and lag MBfRs had similar microbial communities. Denitrifying bacteria dominated the biofilm when the NO3(-) + O2 fluxes were highest, but sulfate-reducing bacteria became more important when SO4(2-) reduction was enhanced in the lag MBfR due to low NO3(-) + O2 flux. The practical two-stage strategy to achieve complete ClO4(-) and NO3(-) reduction while suppressing SO4(2-) reduction involved controlling the NO3(-) + O2 surface loading between 0.18 and 0.34 g H2/m(2)-d and using a low H2 pressure in the lag MBfR.

  16. Development of a replacement for trichloroethylene in the two-stage cleaning process

    SciTech Connect

    Harding, W.B.

    1992-12-01

    A solvent was sought to replace trichloroethylene in the two-stage cleaning process that is used in the Allied-Signal Inc., Kansas City Division (KCD) Miniature Electro-Mechanical Assembly Department. The process is an ultrasonic cleaning process in which product is first cleaned in trichloroethylene and then in isopropyl alcohol. After a general review of the properties of available solvents, isopropyl alcohol, d-limonene, and a synthetic mineral spirits, were chosen to be evaluated as trichloroethylene replacements. Stainless steel test panels were cleaned and then soiled with several different organic materials. Certain of the panels were cleaned by the two-stage process. The others were cleaned by the two-stage process using one or another of the solvents under evaluation in the place of the trichloroethylene. The cleanliness of the panels was determined by Auger and photoelectron spectroscopy. The panels cleaned with any of the three solvents under evaluation were found to be as clean as those cleaned by the standard two-stage process. Because of simplicity and minimization of inventory, it is recommended that the two-stage process be changed to use isopropyl alcohol in both stages.

  17. New LANL Group M-7 two-stage gun: Double-diaphragm and wrap-around gas breech

    SciTech Connect

    Sheffield, S.A.; Martinez, A.R.

    1992-01-01

    A new two-stage gun is being installed in a high explosive testing facility at Los Alamos National Laboratory for the purpose of subjecting insensitive high explosives to controlled projectile impacts so that shock-to-detonation transition can be studied in detail. This gun has been patterned after guns designed by Alois Stilp at Ernst Mach Institut (EMI) in Freiburg and Wintersweiler, Germany. Several changes were made to adapt the design to our needs. The gun has a 100-mm diameter pump tube and 33-mm and 50-mm diameter launch tubes; both pump and launch tubes are 7.6 m long. We plan to use only helium as the reservoir gas. Large hydraulic clamps hold the gun together in three places during a shot; these are located on both sides of the transition section and at the breech. These clamps make gun conversions to different setups relatively simple, i.e., the two-stage gun can be converted into a single-stage gun. A gas breech has been designed which can be operated in either wrap-around or double-diaphragm mode with a maximum operating pressure of 15,000 psi. Two-stage gun calculations indicate that in the gas breech configuration, projectile velocities up to 4 km/s can be obtained using helium in both the breech and the reservoir. The gun has been fabricated and is being installed at the present time. Testing is expected to begin in early 1993 if the startup difficulties do not become excessive.

  18. New LANL Group M-7 two-stage gun: Double-diaphragm and wrap-around gas breech

    SciTech Connect

    Sheffield, S.A.; Martinez, A.R.

    1992-10-01

    A new two-stage gun is being installed in a high explosive testing facility at Los Alamos National Laboratory for the purpose of subjecting insensitive high explosives to controlled projectile impacts so that shock-to-detonation transition can be studied in detail. This gun has been patterned after guns designed by Alois Stilp at Ernst Mach Institut (EMI) in Freiburg and Wintersweiler, Germany. Several changes were made to adapt the design to our needs. The gun has a 100-mm diameter pump tube and 33-mm and 50-mm diameter launch tubes; both pump and launch tubes are 7.6 m long. We plan to use only helium as the reservoir gas. Large hydraulic clamps hold the gun together in three places during a shot; these are located on both sides of the transition section and at the breech. These clamps make gun conversions to different setups relatively simple, i.e., the two-stage gun can be converted into a single-stage gun. A gas breech has been designed which can be operated in either wrap-around or double-diaphragm mode with a maximum operating pressure of 15,000 psi. Two-stage gun calculations indicate that in the gas breech configuration, projectile velocities up to 4 km/s can be obtained using helium in both the breech and the reservoir. The gun has been fabricated and is being installed at the present time. Testing is expected to begin in early 1993 if the startup difficulties do not become excessive.

  19. Design and construction of the X-2 two-stage free piston driven expansion tube

    NASA Technical Reports Server (NTRS)

    Doolan, Con

    1995-01-01

    This report outlines the design and construction of the X-2 two-stage free piston driven expansion tube. The project has completed its construction phase and the facility has been installed in the new impulsive research laboratory where commissioning is about to take place. The X-2 uses a unique, two-stage driver design which allows a more compact and lower overall cost free piston compressor. The new facility has been constructed in order to examine the performance envelope of the two-stage driver and how well it couple to sub-orbital and super-orbital expansion tubes. Data obtained from these experiments will be used for the design of a much larger facility, X-3, utilizing the same free piston driver concept.

  20. Two-Stage Revision Anterior Cruciate Ligament Reconstruction: Bone Grafting Technique Using an Allograft Bone Matrix.

    PubMed

    Chahla, Jorge; Dean, Chase S; Cram, Tyler R; Civitarese, David; O'Brien, Luke; Moulton, Samuel G; LaPrade, Robert F

    2016-02-01

    Outcomes of primary anterior cruciate ligament (ACL) reconstruction have been reported to be far superior to those of revision reconstruction. However, as the incidence of ACL reconstruction is rapidly increasing, so is the number of failures. The subsequent need for revision ACL reconstruction is estimated to occur in up to 13,000 patients each year in the United States. Revision ACL reconstruction can be performed in one or two stages. A two-stage approach is recommended in cases of improper placement of the original tunnels or in cases of unacceptable tunnel enlargement. The aim of this study was to describe the technique for allograft ACL tunnel bone grafting in patients requiring a two-stage revision ACL reconstruction. PMID:27274452

  1. Two-Stage Revision Anterior Cruciate Ligament Reconstruction: Bone Grafting Technique Using an Allograft Bone Matrix.

    PubMed

    Chahla, Jorge; Dean, Chase S; Cram, Tyler R; Civitarese, David; O'Brien, Luke; Moulton, Samuel G; LaPrade, Robert F

    2016-02-01

    Outcomes of primary anterior cruciate ligament (ACL) reconstruction have been reported to be far superior to those of revision reconstruction. However, as the incidence of ACL reconstruction is rapidly increasing, so is the number of failures. The subsequent need for revision ACL reconstruction is estimated to occur in up to 13,000 patients each year in the United States. Revision ACL reconstruction can be performed in one or two stages. A two-stage approach is recommended in cases of improper placement of the original tunnels or in cases of unacceptable tunnel enlargement. The aim of this study was to describe the technique for allograft ACL tunnel bone grafting in patients requiring a two-stage revision ACL reconstruction.

  2. Effects of earthworm casts and zeolite on the two-stage composting of green waste.

    PubMed

    Zhang, Lu; Sun, Xiangyang

    2015-05-01

    Because it helps protect the environment and encourages economic development, composting has become a viable method for organic waste disposal. The objective of this study was to investigate the effects of earthworm casts (EWCs) (at 0.0%, 0.30%, and 0.60%) and zeolite (clinoptilolite, CL) (at 0%, 15%, and 25%) on the two-stage composting of green waste. The combination of EWCs and CL improved the conditions of the composting process and the quality of the compost products in terms of the thermophilic phase, humification, nitrification, microbial numbers and enzyme activities, the degradation of cellulose and hemicellulose, and physico-chemical characteristics and nutrient contents of final composts. The compost matured in only 21days with the optimized two-stage composting method rather than in the 90-270days required for traditional composting. The optimal two-stage composting and the best quality compost were obtained with 0.30% EWCs and 25% CL.

  3. Proceedings of the 1985 pressure vessels and piping conference. Volume PVP-98-8. Fracture, fatigue and advanced mechanics

    SciTech Connect

    Short, W.E.; Zamrik, S.Y.

    1985-01-01

    State-of-the-art engineering practices in pressure vessel and piping technology are the result of continual efforts in the evaluation of problems which have been experienced and the development of appropriate design and analysis methods for those applications. The resulting advances in technology benefit industry with properly engineered, safe, cost-effective pressure vessels and piping systems. To this end, advanced study continues in specialized areas of mechanical engineering such as fracture mechanics, experimental stress analysis, high pressure applications and related material considerations, as well as advanced techniques for evaluation of commonly encountered design problems. This volume is comprised of current technical papers on various aspects of fracture, fatigue and advanced mechanics as related to the design and analysis of pressure vessels and piping.

  4. Characterisation of two-stage ignition in diesel engine-relevant thermochemical conditions using direct numerical simulation

    DOE PAGES

    Krisman, Alex; Hawkes, Evatt R.; Talei, Mohsen; Bhagatwala, Ankit; Chen, Jacqueline H.

    2016-08-30

    With the goal of providing a more detailed fundamental understanding of ignition processes in diesel engines, this study reports analysis of a direct numerical simulation (DNS) database. In the DNS, a pseudo turbulent mixing layer of dimethyl ether (DME) at 400 K and air at 900 K is simulated at a pressure of 40 atmospheres. At these conditions, DME exhibits a two-stage ignition and resides within the negative temperature coefficient (NTC) regime of ignition delay times, similar to diesel fuel. The analysis reveals a complex ignition process with several novel features. Autoignition occurs as a distributed, two-stage event. The high-temperaturemore » stage of ignition establishes edge flames that have a hybrid premixed/autoignition flame structure similar to that previously observed for lifted laminar flames at similar thermochemical conditions. In conclusion, a combustion mode analysis based on key radical species illustrates the multi-stage and multi-mode nature of the ignition process and highlights the substantial modelling challenge presented by diesel combustion.« less

  5. The theory and a technique for an efficiency enhancing two stage bottoming cycle for piston/cylinder engines

    SciTech Connect

    Wicks, F.; Zeh, D.

    1995-12-31

    While there is now much interest in electric vehicles or various hybrids, the most benefit may result from a revolutionary modification and efficiency improvement of the conventional internal combustion Otto cycle engine, by recovering a large portion of the availability that exists at the end of the power stroke. This paper will describe the theory and a potentially practical method for achieving a 50% improvement in power output and fuel efficiency. While the topping cycle will remain the internal combustion piston/cylinder engine, a two stage bottom cycle will be used. The first bottom stage is a single process consisting of a turbine installed in the exhaust stream to extract power from the excess pressure that exists when the engine exhaust valve opens. The second bottom stage is a complete external combustion gas turbine cycle consisting of a compressor, exhaust gas to compressed air heat exchanger and a turbine. Such a two stage bottoming cycle can be practical and may increase the power output by about 50%. This means that a car that achieves 30 mpg without a bottoming cycle can achieve 45 mpg with this bottoming cycle. Alternatively if the performance of cars can be improved to 66 mpg by means of decreasing the power requirements with smaller size and frontal area, better aerodynamics, lower rolling resistance tires and better transmission and drive trains, this vehicle can be extended to 100 mpg with this combined cycle engine.

  6. Two-stage multi-Gaussian fitting of conduit artery photoplethysmography waveform during induced unilateral hemodynamic events

    NASA Astrophysics Data System (ADS)

    Grabovskis, Andris; Marcinkevics, Zbignevs; Rubins, Uldis; Aivars, Juris Imants

    2015-03-01

    Photoplethysmography (PPG) is an optical technique with high diagnostic potential, yet clinical applications remain underdeveloped. Standardization of signal recording and quantification of waveform are essential prerequisites for broader clinical use. The aim of this study was to utilize a two-stage multi-Gaussian fitting technique in order to examine the parameters of conduit artery PPG waveform recorded during increasing the unilateral regional vascular resistance (RVR). This study was conducted on 14 young and healthy volunteers; various external compressions (ECs) were performed by inflating a tight cuff at 0, 40, 80, and 200 mmHg, while registering femoral PPG (wavelength 880 nm), diameter, blood flow linear velocity (vascular ultrasound), and the arterial pressure (Finapres) during the states of the baseline, partial, and total arterial occlusion, and resultant reactive hyperemia. An increase of the EC elevated the arterial stiffness (AS) and the unilateral distal RVR, and caused a shift of the fitted multi-Gaussian parameters: a decreased delay between reflected and traverse wave components and an increased ratio of their amplitudes. It was concluded that two-stage multi-Gaussian waveform quantification demonstrates an approach potentially extending the use of arterial site PPG in the assessment of diagnostically useful markers e.g., the RVR and the AS.

  7. Two-stage high-rate biogas (H2 and CH4) production from food waste using anaerobic mixed microflora

    NASA Astrophysics Data System (ADS)

    Xu, K.; Lee, D.; Kobayashi, T.; Ebie, Y.; Li, Y.; Inamori, Y.

    2010-12-01

    To achieve the high-rate H2 and CH4 production from food waste using fermentative anaerobic microflora, the effects of carbonate-alkalinity in the recirculated digestion sludge on continuous two-stage fermentation were investigated. Higher H2 production rate of 2.9 L-H2/L/day was achieved at the recycle ratio of 1.0 in an alkalinity range of 9000 to 10000 mg-CaCO3/L. The maximum CH4 production rate was stably maintained at the range of 1.85 to 1.88 L-CH4/L/day without alkalinity change. Carbonate alkalinity in digestion sludge could reduce the H2 partial pressure in the headspace of the fermentation reactors, and improve a biogas production capacity in the two-stage fermentation process. The average volatile solids degradation rate in the overall process increased as the digestion sludge recycle increased from 0.5 to 1.0. These results show that the alkalinity in recycle of the digestion sludge is crucial factor in determining biogas (H2 and CH4) production capacity and reducing the total solids.

  8. Measuring the performance of Internet companies using a two-stage data envelopment analysis model

    NASA Astrophysics Data System (ADS)

    Cao, Xiongfei; Yang, Feng

    2011-05-01

    In exploring the business operation of Internet companies, few researchers have used data envelopment analysis (DEA) to evaluate their performance. Since the Internet companies have a two-stage production process: marketability and profitability, this study employs a relational two-stage DEA model to assess the efficiency of the 40 dot com firms. The results show that our model performs better in measuring efficiency, and is able to discriminate the causes of inefficiency, thus helping business management to be more effective through providing more guidance to business performance improvement.

  9. Mechanisms to deploy the two-stage IUS from the shuttle cargo bay

    NASA Technical Reports Server (NTRS)

    Haynie, H. T.

    1980-01-01

    The Inertial Upper Stage (IUS) is a two-stage or three-stage booster used to transport spacecraft from the space shuttle orbit to synchronous orbit or on an interplanetary trajectory. The mechanisms which were designed specifically to perform the two-stage IUS required functions while contained within the cargo bay of the space shuttle during the boost phase and while in a low Earth orbit are discussed. The requirements, configuration, and operation of the mechanisms are described, with particular emphasis on the tilt actuator and the mechanism for decoupling the actuators during boost to eliminate redundant load paths.

  10. TRAC-PF1: an advanced best-estimate computer program for pressurized water reactor analysis

    SciTech Connect

    Liles, D.R.; Mahaffy, J.H.

    1984-02-01

    The Transient Reactor Analysis Code (TRAC) is being developed at the Los Alamos National Laboratory to provide advanced best-estimate predictions of postulated accidents in light water reactors. The TRAC-PF1 program provides this capability for pressurized water reactors and for many thermal-hydraulic experimental facilities. The code features either a one-dimensional or a three-dimensional treatment of the pressure vessel and its associated internals; a two-phase, two-fluid nonequilibrium hydrodynamics model with a noncondensable gas field; flow-regime-dependent constitutive equation treatment; optional reflood tracking capability for both bottom flood and falling-film quench fronts; and consistent treatment of entire accident sequences including the generation of consistent initial conditions. This report describes the thermal-hydraulic models and the numerical solution methods used in the code. Detailed programming and user information also are provided.

  11. High-pressure hydrogen testing of single crystal superalloys for advanced rocket engine turbopump turbine blades

    NASA Technical Reports Server (NTRS)

    Alter, W. S.; Parr, R. A.; Johnston, M. H.; Strizak, J. P.

    1984-01-01

    A screening program to determine the effects of high pressure hydrogen on selected candidate materials for advanced single crystal turbine blade applications is examined. The alloys chosen for the investigation are CM SX-2, CM SX-4C, Rene N-4, and PWA1480. Testing is carried out in hydrogen and helium at 34 MPa and room temperature, with both notched and unnotched single crystal specimens. Results show a significant variation in susceptibility to Hydrogen Environment Embrittlement (HEE) among the four alloys and a marked difference in fracture topography between hydrogen and helium environment specimens.

  12. High-pressure hydrogen testing of single crystal superalloys for advanced rocket engine turbopump turbine blades

    NASA Technical Reports Server (NTRS)

    Parr, R. A.; Alter, W. S.; Johnston, M. H.; Strizak, J. P.

    1985-01-01

    A screening program to determine the effects of high pressure hydrogen on selected candidate materials for advanced single crystal turbine blade applications is examined. The alloys chosen for the investigation are CM SX-2, CM SX-4C, Rene N-4, and PWA1480. Testing is carried out in hydrogen and helium at 34 MPa and room temperature, with both notched and unnotched single crystal specimens. Results show a significant variation in susceptibility to Hydrogen Environment Embrittlement (HEE) among the four alloys and a marked difference in fracture topography between hydrogen and helium environment specimens.

  13. Advances in high-resolution RIXS for the study of excitation spectra under high pressure

    NASA Astrophysics Data System (ADS)

    Kim, Jungho

    2016-07-01

    Hard X-ray resonant inelastic X-ray scattering (RIXS) is a promising X-ray spectroscopic tool for measuring low-energy excitation spectra from complex materials under high pressure. In the past, these measurements have been stymied by technical difficulties inherent in measuring a tiny sample, held at high pressure, inside a diamond anvil cell. Now, due to substantial advances in X-ray instrumentation, high-resolution (? meV) RIXS spectrometers at third-generation synchrotron radiation sources have started to successfully address these samples in their extreme environment. However, compared to elastic X-ray scattering and X-ray emission spectroscopy, RIXS is a very photon hungry technique and high-resolution RIXS for samples under high pressure is in its infancy. In this review, the fundamentals of the high-resolution RIXS and associated instrumentation are presented, as well as technical details of diamond anvil cells, sample preparation, and the measurement geometry. Experimental data from measurements of 3d- and 5d-transition metal oxides are shown and future improvements of the RIXS technique in the context of high pressure are discussed.

  14. Advanced turboprop wing installation effects measured by unsteady blade pressure and noise

    NASA Technical Reports Server (NTRS)

    Heidelberg, Laurence J.; Woodward, Richard P.

    1987-01-01

    A single rotation model propeller (SR-7A) was tested at simulated takeoff/approach conditions (Mach 0.2), in the NASA Lewis 9- by 15-Ft Anechoic Wind Tunnel. Both unsteady blade surface pressures and noise measurements were made for a tractor configuration with propeller/straight wing and propeller alone configurations. The angle between the wing chord and propeller axis (droop angle) was varied along with the wing angle of attack to determine the effects on noise and unsteady loading. A method was developed that uses unsteady blade pressure measurements to provide a quantitative indication of propeller inflow conditions, at least for a uniform (across the propeller disk) inflow angle. The wing installation caused a nearly uniform upwash at the propeller inlet as evidenced by the domination of the pressure spectra by the first shaft order. This inflow angle increased at a rate of almost 150 percent of that of the wing angle-of-attack for a propeller-wing spacing of 0.54 wing chords at a constant droop angle. The flyover noise, as measured by the maximum blade passing frequency level, correlates closely with the propeller inflow angle (approx. 0.6 dB per degree of inflow angle) for all droop angles and wing angles of attack tested, including the propeller alone data. Large changes in the unsteady pressure responses on the suction surface of the blade were observed as the advance ratio was varied. The presence of a leading edge vortex may explain this behavior since changes in the location of this vortex would change with loading (advance ratio).

  15. Use a Log Splitter to Demonstrate Two-Stage Hydraulic Pump

    ERIC Educational Resources Information Center

    Dell, Timothy W.

    2012-01-01

    The two-stage hydraulic pump is commonly used in many high school and college courses to demonstrate hydraulic systems. Unfortunately, many textbooks do not provide a good explanation of how the technology works. Another challenge that instructors run into with teaching hydraulic systems is the cost of procuring an expensive real-world machine…

  16. EVALUATION OF A TWO-STAGE PASSIVE TREATMENT APPROACH FOR MINING INFLUENCE WATERS

    EPA Science Inventory

    A two-stage passive treatment approach was assessed at bench-scale using two Colorado Mining Influenced Waters (MIWs). The first-stage was a limestone drain with the purpose of removing iron and aluminum and mitigating the potential effects of mineral acidity. The second stage w...

  17. Thermal design of two-stage evaporative cooler based on thermal comfort criterion

    NASA Astrophysics Data System (ADS)

    Gilani, Neda; Poshtiri, Amin Haghighi

    2016-09-01

    Performance of two-stage evaporative coolers at various outdoor air conditions was numerically studied, and its geometric and physical characteristics were obtained based on thermal comfort criteria. For this purpose, a mathematical model was developed based on conservation equations of mass, momentum and energy to determine heat and mass transfer characteristics of the system. The results showed that two-stage indirect/direct cooler can provide the thermal comfort condition when outdoor air temperature and relative humidity are located in the range of 34-54 °C and 10-60 %, respectively. Moreover, as relative humidity of the ambient air rises, two-stage evaporative cooler with the smaller direct and larger indirect cooler will be needed. In building with high cooling demand, thermal comfort may be achieved at a greater air change per hour number, and thus an expensive two-stage evaporative cooler with a higher electricity consumption would be required. Finally, a design guideline was proposed to determine the size of required plate heat exchangers at various operating conditions.

  18. Two stage activated sludge plants--influence of different operational modes on sludge bulking and nitrification.

    PubMed

    Wandl, G; Müller-Rechberger, H; Matsché, N; Svardal, K; Winkler, S

    2002-01-01

    Conventional two stage activated sludge plants often lack sufficient nutrient removal performance due to substrate limitation for denitrification in the second stage. For the extension of the Vienna Main WWTP a two stage concept has been developed and tested by means of a pilot plant (scale 1:10.000). The new concept enables the operation of two different modes: In BYPASS-mode a portion of the primary clarifier effluent is fed directly to the second stage; the HYBRID-mode includes the exchange of mixed liquor between the two stages; over the course of the pilot plant investigations it turned out that nutrient removal is strongly increased in comparison to conventional two stage mode, but the two modes of operation lead to different results with regard to the sludge quality and the nitrification performance. BYPASS mode yields a higher SVI in both stages and a lower nitrification performance in comparison to HYBRID mode. This is caused by the negative influence of the primary effluent on the biocoenosis of the second stage. Additionally, the reduced sludge loading of the first stage in this mode results in a higher sludge age which favours the growth of filaments (Microthrix and Nocardia). In HYBRID-mode the higher load of the first stage results in a lower sludge age, fatty components are metabolized and incorporated in the sludge, thus, the growth of filaments is significantly reduced. Additionally, nitrification inhibiting substances are degraded in the first stage, which results in a higher nitrification performance in the second stage.

  19. An Alternative Two Stage Least Squares (2SLS) Estimator for Latent Variable Equations.

    ERIC Educational Resources Information Center

    Bollen, Kenneth A.

    1996-01-01

    An alternative two-stage least squares (2SLS) estimator of the parameters in LISREL type models is proposed and contrasted with existing estimators. The new 2SLS estimator allows observed and latent variables to originate from nonnormal distributions, is consistent, has a known asymptotic covariance matrix, and can be estimated with standard…

  20. Extraoral implants for orbit rehabilitation: a comparison between one-stage and two-stage surgeries.

    PubMed

    de Mello, M C L M P; Guedes, R; de Oliveira, J A P; Pecorari, V A; Abrahão, M; Dib, L L

    2014-03-01

    The aim of the study was to compare the osseointegration success rate and time for delivery of the prosthesis among cases treated by two-stage or one-stage surgery for orbit rehabilitation between 2003 and 2011. Forty-five patients were included, 31 males and 14 females; 22 patients had two-stage surgery and 23 patients had one-stage surgery. A total 138 implants were installed, 42 (30.4%) on previously irradiated bone. The implant survival rate was 96.4%, with a success rate of 99.0% among non-irradiated patients and 90.5% among irradiated patients. Two-stage patients received 74 implants with a survival rate of 94.6% (four implants lost); one-stage surgery patients received 64 implants with a survival rate of 98.4% (one implant lost). The median time interval between implant fixation and delivery of the prosthesis for the two-stage group was 9.6 months and for the one-stage group was 4.0 months (P < 0.001). The one-stage technique proved to be reliable and was associated with few risks and complications; the rate of successful osseointegration was similar to those reported in the literature. The one-stage technique should be considered a viable procedure that shortens the time to final rehabilitation and facilitates appropriate patient follow-up treatment.

  1. Treatment of corn ethanol distillery wastewater using two-stage anaerobic digestion.

    PubMed

    Ráduly, B; Gyenge, L; Szilveszter, Sz; Kedves, A; Crognale, S

    2016-01-01

    In this study the mesophilic two-stage anaerobic digestion (AD) of corn bioethanol distillery wastewater is investigated in laboratory-scale reactors. Two-stage AD technology separates the different sub-processes of the AD in two distinct reactors, enabling the use of optimal conditions for the different microbial consortia involved in the different process phases, and thus allowing for higher applicable organic loading rates (OLRs), shorter hydraulic retention times (HRTs) and better conversion rates of the organic matter, as well as higher methane content of the produced biogas. In our experiments the reactors have been operated in semi-continuous phase-separated mode. A specific methane production of 1,092 mL/(L·d) has been reached at an OLR of 6.5 g TCOD/(L·d) (TCOD: total chemical oxygen demand) and a total HRT of 21 days (5.7 days in the first-stage, and 15.3 days in the second-stage reactor). Nonetheless the methane concentration in the second-stage reactor was very high (78.9%); the two-stage AD outperformed the reference single-stage AD (conducted at the same reactor loading rate and retention time) by only a small margin in terms of volumetric methane production rate. This makes questionable whether the higher methane content of the biogas counterbalances the added complexity of the two-stage digestion. PMID:27438248

  2. An investigation of soft launch and instability breakup with a two-stage light gas gun

    SciTech Connect

    Grady, D.E.; Moody, R.L.

    1988-05-01

    Exploratory research has been performed in the use of a two-stage light gas gun facility to investigate the soft acceleration and breakup physics of rapidly launched thin plates. A flash radiograph system was joined with the gun facility to provide the principal diagnostic. In the study, radiographs of thin-plate acceleration and breakup were obtained.

  3. Magnetic gauge instrumentation on the LANL gas-driven two-stage gun

    SciTech Connect

    Alcon, R.R.; Sheffield, S.A.; Martinez, A.R.; Gustavsen, R.L.

    1997-11-01

    The LANL gas-driven two-stage gun was designed and built to do initiation studies on insensitive high explosives as well as equation of state and reaction experiments on other materials. The preferred method of measuring reaction phenomena involves the use of in-situ magnetic particle velocity gauges. In order to accommodate this type of gauging in the two-stage gun, it has a 50-mm-diameter launch tube. The authors have sued magnetic gauging on the 72-mm bore diameter single-stage gun for over 15 years and it has proven a very effective technique for all types of shock wave experiments, including those on high explosives. This technique has now been installed on the gas-driven two-stage gun. They describe the method used, as well as some of the difficulties that arose during the installation. Several magnetic gauge experiments have been completed on plastic materials. Waveforms obtained in some of the experiments will be discussed. Up to 10 in-situ particle velocity measurements can be made in a single experiment. This new technique is now working quite well, as is evidenced by the data. To their knowledge, this is the first time magnetic gauging has been used on a two-stage gun.

  4. Assessing Compliance-Effect Bias in the Two Stage Least Squares Estimator

    ERIC Educational Resources Information Center

    Reardon, Sean; Unlu, Fatih; Zhu, Pei; Bloom, Howard

    2011-01-01

    The proposed paper studies the bias in the two-stage least squares, or 2SLS, estimator that is caused by the compliance-effect covariance (hereafter, the compliance-effect bias). It starts by deriving the formula for the bias in an infinite sample (i.e., in the absence of finite sample bias) under different circumstances. Specifically, it…

  5. Magnetic induction system for two-stage gun projectile velocity measurements

    SciTech Connect

    Moody, R L; Konrad, C H

    1984-05-01

    A magnetic induction technique for measuring projectile velocities has been implemented on Sandia's two-stage light gas gun. The system has been designed to allow for projectile velocity measurements to an accuracy of approx. 0.2 percent. The velocity system has been successfully tested in a velocity range of 3.5 km/s to 6.5 km/s.

  6. Development and Evaluation of Hierarchical Testlets in Two-Stage Tests Using Integer Linear Programming.

    ERIC Educational Resources Information Center

    Lam, Tit-Loong; Foong, Yoke-Yeen

    This simulation study involved the design of two two-stage tests in which the routing tests and the second-stage measurement testlets took the form of a multidimensional knapsack problem with prespecified target informations and constraints to be enumerated using the algorithm of E. Balas. Two conventional tests of similar length to the two-stage…

  7. Biomass waste gasification - Can be the two stage process suitable for tar reduction and power generation?

    SciTech Connect

    Sulc, Jindrich; Stojdl, Jiri; Richter, Miroslav; Popelka, Jan; Svoboda, Karel; Smetana, Jiri; Vacek, Jiri; Skoblja, Siarhei; Buryan, Petr

    2012-04-15

    Highlights: Black-Right-Pointing-Pointer Comparison of one stage (co-current) and two stage gasification of wood pellets. Black-Right-Pointing-Pointer Original arrangement with grate-less reactor and upward moving bed of the pellets. Black-Right-Pointing-Pointer Two stage gasification leads to drastic reduction of tar content in gas. Black-Right-Pointing-Pointer One stage gasification produces gas with higher LHV at lower overall ER. Black-Right-Pointing-Pointer Content of ammonia in gas is lower in two stage moving bed gasification. - Abstract: A pilot scale gasification unit with novel co-current, updraft arrangement in the first stage and counter-current downdraft in the second stage was developed and exploited for studying effects of two stage gasification in comparison with one stage gasification of biomass (wood pellets) on fuel gas composition and attainable gas purity. Significant producer gas parameters (gas composition, heating value, content of tar compounds, content of inorganic gas impurities) were compared for the two stage and the one stage method of the gasification arrangement with only the upward moving bed (co-current updraft). The main novel features of the gasifier conception include grate-less reactor, upward moving bed of biomass particles (e.g. pellets) by means of a screw elevator with changeable rotational speed and gradual expanding diameter of the cylindrical reactor in the part above the upper end of the screw. The gasifier concept and arrangement are considered convenient for thermal power range 100-350 kW{sub th}. The second stage of the gasifier served mainly for tar compounds destruction/reforming by increased temperature (around 950 Degree-Sign C) and for gasification reaction of the fuel gas with char. The second stage used additional combustion of the fuel gas by preheated secondary air for attaining higher temperature and faster gasification of the remaining char from the first stage. The measurements of gas composition and tar

  8. Two-stage fan. 3: Data and performance with rotor tip casing treatment, uniform and distorted inlet flows

    NASA Technical Reports Server (NTRS)

    Burger, G. D.; Hodges, T. R.; Keenan, M. J.

    1975-01-01

    A two stage fan with a 1st-stage rotor design tip speed of 1450 ft/sec, a design pressure ratio of 2.8, and corrected flow of 184.2 lbm/sec was tested with axial skewed slots in the casings over the tips of both rotors. The variable stagger stators were set in the nominal positions. Casing treatment improved stall margin by nine percentage points at 70 percent speed but decreased stall margin, efficiency, and flow by small amounts at design speed. Treatment improved first stage performance at low speed only and decreased second stage performance at all operating conditions. Casing treatment did not affect the stall line with tip radially distorted flow but improved stall margin with circumferentially distorted flow. Casing treatment increased the attenuation for both types of inlet flow distortion.

  9. Mach 6.5 air induction system design for the Beta 2 two-stage-to-orbit booster vehicle

    NASA Technical Reports Server (NTRS)

    Midea, Anthony C.

    1991-01-01

    A preliminary, two-dimensional, mixed compression air induction system is designed for the Beta II Two Stage to Orbit booster vehicle to minimize installation losses and efficiently deliver the required airflow. Design concepts, such as an external isentropic compression ramp and a bypass system were developed and evaluated for performance benefits. The design was optimized by maximizing installed propulsion/vehicle system performance. The resulting system design operating characteristics and performance are presented. The air induction system design has significantly lower transonic drag than similar designs and only requires about 1/3 of the bleed extraction. In addition, the design efficiently provides the integrated system required airflow, while maintaining adequate levels of total pressure recovery. The excellent performance of this highly integrated air induction system is essential for the successful completion of the Beta II booster vehicle mission.

  10. Mach 6.5 air induction system design for the Beta II Two-Stage-to-Orbit booster vehicle

    NASA Technical Reports Server (NTRS)

    Midea, Anthony C.

    1991-01-01

    A preliminary, two-dimensional, mixed compression air induction system is designed for the Beta II Two-Stage-to-Orbit booster vehicle to minimize installation losses and efficiently deliver the required airflow. Design concepts, such as an external isentropic compression ramp and a bypass system, are developed and evaluated for performance benefits. The design is optimized by maximizing installed propulsion/vehicle system performance, and the resulting system design operating characteristics and performance are presented. The air induction system design has significantly lower transonic drag than similar designs, and only requires approximately 1/3 of the bleed extraction. In addition, the design efficiently provides the integrated system required airflow, while maintaining adequate levels of total pressure recovery. The excellent performance of this highly integrated air induction system is essential for the successful completion of the Beta II booster vehicle mission.

  11. Drinking water treatment of priority pesticides using low pressure UV photolysis and advanced oxidation processes.

    PubMed

    Sanches, Sandra; Barreto Crespo, Maria T; Pereira, Vanessa J

    2010-03-01

    This study reports the efficiency of low pressure UV photolysis for the degradation of pesticides identified as priority pollutants by the European Water Framework Directive 2000/60/EC. Direct low pressure UV photolysis and advanced oxidation processes (using hydrogen peroxide and titanium dioxide) experiments were conducted in laboratory grade water, surface water, and groundwater. LP direct photolysis using a high UV fluence (1500 mJ/cm(2)) was found to be extremely efficient to accomplish the degradation of all pesticides except isoproturon, whereas photolysis using hydrogen peroxide and titanium dioxide did not significantly enhance their removal. In all matrices tested the experimental photolysis of the pesticides followed the same trend: isoproturon degradation was negligible, alachlor, pentachlorophenol, and atrazine showed similar degradation rate constants, whereas diuron and chlorfenvinphos were highly removed. The degradation trend observed for the selected compounds followed the decadic molar absorption coefficients order with exception of isoproturon probably due to its extremely low quantum yield. Similar direct photolysis rate constants were obtained for each pesticide in the different matrices tested, showing that the water components did not significantly impact degradation. Extremely similar photolysis rate constants were also obtained in surface water for individual compounds when compared to mixtures. The model fluence and time-based rate constants reported were very similar to the direct photolysis experimental results obtained, while overestimating the advanced oxidation results. This model was used to predict how degradation of isoproturon, the most resilient compound, could be improved.

  12. Slumped glass optics for x-ray telescopes: advances in the hot slumping assisted by pressure

    NASA Astrophysics Data System (ADS)

    Salmaso, B.; Brizzolari, C.; Basso, S.; Civitani, M.; Ghigo, M.; Pareschi, G.; Spiga, D.; Tagliaferri, G.; Vecchi, G.

    2015-09-01

    Slumped Glass Optics is a viable solution to build future X-ray telescopes. In our laboratories we use a direct hot slumping approach assisted by pressure, in which the glass optical surface is in contact with the mould, and a pressure is applied to enforce the replication of the mould shape on the glass optical surface. Several prototypes have been already produced and tested in X-rays, showing a continuous improvement in our technology. In this paper, we present the advances in our technology, in terms of slumped glass foils quality and expected performances upon an ideal integration. By using Eagle XG glass foils and Zerodur K20 for the slumping mould, we have fine tuned several process parameters: we present a critical analysis correlating the changes in the process to the improvements in different spatial frequency ranges encompassing the profile and roughness measurements. The use of a re-polished K20 mould, together with the optimized process parameters, lead to the latest result of glass foils with expected performance of less than 3 arcsec in single reflection at 1 keV X-ray energy. This work presents all the relevant steps forward in the hot slumping technology assisted by pressure, aimed at reaching angular resolutions of 5 arcsec for the whole mirror assembly.

  13. Evaluation of the two-stage ditch as a best management practice

    NASA Astrophysics Data System (ADS)

    Hodaj, A.; Bowling, L. C.; Cibin, R.; Chaubey, I.

    2015-12-01

    Artificial drainage has long been an important component of agriculture in the poorly-drained regions of the US Corn Belt. Continued increases in drainage intensity funnel more water into existing drainage ditches, resulting in higher flood stages, more erosive water velocities and decreased time for in-channel nutrient processing. The two-stage ditch is a type of in-stream restoration that involves modification of a trapezoidal drainage ditch to resemble more the features of a natural stream. The idea is to create or simulate extended benches on both sides of the ditch that would develop naturally over a period of time in a stream because of geomorphological processes. These in-channel flood plains provide a greater flow area during high flow events and offer the potential to reduce sediment load and extend the interaction time between water and vegetation on the benches, allowing larger uptake of nutrients and increasing the denitrification rates in the bench soil. The Soil and Water Assessment Tool (SWAT) hydrologic model has recently been modified to represent the two-stage ditch as a conservation practice. Processes that are represented in the model include: velocity reductions due to the change in channel geometry, particle settling, plant nutrient uptake and denitrification on the benches of the two-stage ditch. The model is evaluated using data collected from a two-stage ditch constructed at the Throckmorton Purdue Agricultural Center (TPAC) near Lafayette, Indiana in September 2012. It drains an area of approximately 2.7 km2 of farmland used for corn and soybean production. Simulation results for 30 years of weather data indicated the impact of the two-stage ditch on reducing peak flow rates, flood stage and nutrient loads. For this 30 year period, 1985 - 2014, the results showed reductions of up to 40% of peak flow velocities, 35% reduction per km of two-stage ditch, of sediment basin output, 10 - 80% reduction in total phosphorus output and 0 - 15

  14. Extension of the operating parameters of the two stage light gas gun to velocities below 2 km/sec.

    SciTech Connect

    Thoe, R S

    2007-08-28

    The Joint Actinide Shock Physics Experimental Facility (JASPER) located in area 27 at the Nevada Test Site Has been tasked with providing high accuracy information on the Equation Of State (EOS) and other dynamic properties of weapons grade plutonium and other actinides important to the stockpile stewardship program. In the past 5 years this facility has provided dozens of experimental data points for the accurate determination of pressure density relationship for these materials over a broad pressure range. In order to complete this survey it is necessary to extend the low pressure region to include projectile velocities below 2 km/s. For most gas gun facilities this would present not too great a difficulty, one could simply decrease the amount of propellant along with a decrease in the strength of the petal valve, However JASPER requires that the piston be securely embedded in the Acceleration Reservoir (AR) as part of the containment system. The projectile must remain flat and undistorted. This requirement makes the attainment of slow velocities problematic. This talk will discuss the JASPER Facility, A finite difference code developed to give predictive capability for two stage gas guns, and a set of experiments performed to demonstrate this capability.

  15. NASA Lewis advanced individual pressure vessel (IPV) nickel/hydrogen technology

    NASA Astrophysics Data System (ADS)

    Smithrick, John J.; Britton, Doris L.

    Individual pressure vessel (IPV) nickel/hydrogen technology was advanced at NASA Lewis and under Lewis contracts. Some of the advancements are as follows: (1) to use 26% KOH electrolyte to improve cycle life and performance; (ii) to modify the state-of-the-art cell design to eliminate identified failure modes and further improve cycle life, and (iii) to develop a lightweight nickel electrode to reduce battery mass, hence reduce launch and/ or increase satellite payload. A breakthrough in the Low-Earth-Orbit (LEO) cycle life of individual pressure vessel nickel/hydrogen battery cells was reported. The cycle life of boiler plate cells containing 26% KOH electrolyte was about 40 000 accelerated LEO cycles at 80% depth-of-discharge (DOD) compared with 3500 cycles for cells containing 31% KOH. Results of the boiler plate cells tests have been validated at Naval Weapons Support Center, Crane, IN. Forty-eight Ah flight cells containing 26 and 31% KOH have undergone real time LEO cycle life testing at an 80% DOD, in 10 °C. The three cells containing 26% KOH failed on the average at cycle 19 500. The three cells containing 31% KOH failed on the average at cycle 6400. Validation testing of NASA Lewis 125 Ah advanced design IPV nickel/hydrogen flight cells is also being conducted at Naval Weapons Support Center, Crane, IN under a NASA Lewis contract. This consists of characterization, storage, and cycle-life testing. There was no capacity degradation after 52 days of storage with the cells in the discharged state, on open circuit, 0 °C, and a hydrogen pressure of 14.5 psia (1 atm). The catalyzed wall wick cells have been cycled for over 22 694 cycles with no cell failures in the continuing test. All three of the noncatalyzed wall wick cells failed (cycles 9588, 13 900 and 20 575). Cycle-life test results of the Fibrex nickel electrode has demonstrated the feasibility of an improved nickel electrode giving a higher specific energy nickel/hydrogen cell. A nickel

  16. Two-stage electrodialytic concentration of glyceric acid from fermentation broth.

    PubMed

    Habe, Hiroshi; Shimada, Yuko; Fukuoka, Tokuma; Kitamoto, Dai; Itagaki, Masayuki; Watanabe, Kunihiko; Yanagishita, Hiroshi; Sakaki, Keiji

    2010-12-01

    The aim of this research was the application of a two-stage electrodialysis (ED) method for glyceric acid (GA) recovery from fermentation broth. First, by desalting ED, glycerate solutions (counterpart is Na+) were concentrated using ion-exchange membranes, and the glycerate recovery and energy consumption became more efficient with increasing the initial glycerate concentration (30 to 130 g/l). Second, by water-splitting ED, the concentrated glycerate was electroconverted to GA using bipolar membranes. Using a culture broth of Acetobacter tropicalis containing 68.6 g/l of D-glycerate, a final D-GA concentration of 116 g/l was obtained following the two-stage ED process. The total energy consumption for the D-glycerate concentration and its electroconversion to D-GA was approximately 0.92 kWh per 1 kg of D-GA. PMID:20674487

  17. HRI catalytic two-stage liquefaction (CTSL) process materials: chemical analysis and biological testing

    SciTech Connect

    Wright, C.W.; Later, D.W.

    1985-12-01

    This report presents data from the chemical analysis and biological testing of coal liquefaction materials obtained from the Hydrocarbon Research, Incorporated (HRI) catalytic two-stage liquefaction (CTSL) process. Materials from both an experimental run and a 25-day demonstration run were analyzed. Chemical methods of analysis included adsorption column chromatography, high-resolution gas chromatography, gas chromatography/mass spectrometry, low-voltage probe-inlet mass spectrometry, and proton nuclear magnetic resonance spectroscopy. The biological activity was evaluated using the standard microbial mutagenicity assay and an initiation/promotion assay for mouse-skin tumorigenicity. Where applicable, the results obtained from the analyses of the CTSL materials have been compared to those obtained from the integrated and nonintegrated two-stage coal liquefaction processes. 18 refs., 26 figs., 22 tabs.

  18. Sample size reassessment for a two-stage design controlling the false discovery rate.

    PubMed

    Zehetmayer, Sonja; Graf, Alexandra C; Posch, Martin

    2015-11-01

    Sample size calculations for gene expression microarray and NGS-RNA-Seq experiments are challenging because the overall power depends on unknown quantities as the proportion of true null hypotheses and the distribution of the effect sizes under the alternative. We propose a two-stage design with an adaptive interim analysis where these quantities are estimated from the interim data. The second stage sample size is chosen based on these estimates to achieve a specific overall power. The proposed procedure controls the power in all considered scenarios except for very low first stage sample sizes. The false discovery rate (FDR) is controlled despite of the data dependent choice of sample size. The two-stage design can be a useful tool to determine the sample size of high-dimensional studies if in the planning phase there is high uncertainty regarding the expected effect sizes and variability.

  19. Two-stage combustion for reducing pollutant emissions from gas turbine combustors

    NASA Technical Reports Server (NTRS)

    Clayton, R. M.; Lewis, D. H.

    1981-01-01

    Combustion and emission results are presented for a premix combustor fueled with admixtures of JP5 with neat H2 and of JP5 with simulated partial-oxidation product gas. The combustor was operated with inlet-air state conditions typical of cruise power for high performance aviation engines. Ultralow NOx, CO and HC emissions and extended lean burning limits were achieved simultaneously. Laboratory scale studies of the non-catalyzed rich-burning characteristics of several paraffin-series hydrocarbon fuels and of JP5 showed sooting limits at equivalence ratios of about 2.0 and that in order to achieve very rich sootless burning it is necessary to premix the reactants thoroughly and to use high levels of air preheat. The application of two-stage combustion for the reduction of fuel NOx was reviewed. An experimental combustor designed and constructed for two-stage combustion experiments is described.

  20. Assessment of increasing loading rate on two-stage digestion of food waste.

    PubMed

    Voelklein, M A; Jacob, A; O' Shea, R; Murphy, J D

    2016-02-01

    A two-stage food waste digestion system involved a first stage hydrolysis reactor followed by a second stage methanogenic reactor. Organic loading rates (OLR) were increased from 6 to 15 g VS L(-1) d(-1) in the hydrolysis reactor and from 2 to 5 g VS L(-1) d(-1) in the methanogenic reactor. The retention time was fixed at 4 days (hydrolysis reactor) and 12 days (methane reactor). A single-stage digester was subjected to similar loading rates as the methanogenic reactor at 16 days retention. Increased OLR resulted in higher quantities of liquid fermentation products from the first stage hydrolysis reactor. Solubilisation of chemical oxygen demand peaked at 47% at the maximum loading. However, enhanced hydrolysis yields had no significant impact on the specific methane yields. The two-stage system increased methane yields up to 23% and enriched methane content by an average of 14% to levels of 71%. PMID:26708485

  1. A covariate adjusted two-stage allocation design for binary responses in randomized clinical trials.

    PubMed

    Bandyopadhyay, Uttam; Biswas, Atanu; Bhattacharya, Rahul

    2007-10-30

    In the present work, we develop a two-stage allocation rule for binary response using the log-odds ratio within the Bayesian framework allowing the current allocation to depend on the covariate value of the current subject. We study, both numerically and theoretically, several exact and limiting properties of this design. The applicability of the proposed methodology is illustrated by using some data set. We compare this rule with some of the existing rules by computing various performance measures.

  2. Fundamental two-stage formulation for Bayesian system identification, Part I: General theory

    NASA Astrophysics Data System (ADS)

    Au, Siu-Kui; Zhang, Feng-Liang

    2016-01-01

    Structural system identification is concerned with the determination of structural model parameters (e.g., stiffness, mass) based on measured response data collected from the subject structure. For linear structures, one popular strategy is to adopt a 'two-stage' approach. That is, modal identification (e.g., frequency, mode shape) is performed in Stage I, whose information is used for inferring the structural parameters in Stage II. Different variants of Bayesian two-stage formulations have been proposed in the past. A prediction error model is commonly introduced to build a link between Stages I and II, treating the most probable values of the natural frequencies and mode shapes identified in Stage I as 'data' for Stage II. This type of formulation, which casts a prediction error model through descriptive statistics, involves heuristics that distort the fundamental nature of the Bayesian approach, although it has appeared to be inevitable. In this paper, a fundamental theory is developed for the Bayesian two-stage problem. The posterior distribution of structural parameters is derived rigorously in terms of the information available in the problem, namely the prior distribution of structural parameters, the posterior distribution of modal parameters in Stage I and the distribution of modal parameters conditional on the structural parameters that connects Stages I and II. The theory reveals a fundamental principle that ensures no double-counting of prior information in the two-stage identification process. Mathematical statements are also derived that provide insights into the role of the structural modeling error. Beyond the original structural model identification problem that motivated the work, the developed theory can be applied in more general settings. In the companion paper, examples with synthetic and real experimental data are provided to illustrate the proposed theory.

  3. Development of a two-stage membrane-based wash-water reclamation subsystem

    NASA Technical Reports Server (NTRS)

    Mccray, S. B.

    1988-01-01

    A two-stage membrane-based subsystem was designed and constructed to enable the recycle of wash waters generated in space. The first stage is a fouling-resistant tube-side-feed hollow-fiber ultrafiltration module, and the second stage is a spiral-wound reverse-osmosis module. Throughout long-term tests, the subsystem consistently produced high-quality permeate, processing actual wash water to 95 percent recovery.

  4. Two-stage earth-to-orbit transport with translating oblique wings for booster recovery

    NASA Technical Reports Server (NTRS)

    MacConochie, Ian O. (Inventor); Briener, Charles A. (Inventor)

    1991-01-01

    A two-stage earth-to-orbit transport includes an orbiter vehicle and a pair of boosters, each having a depolyable oblique wing located along a longitudinal axis of the booster. The wing is deployed in an oblique disposition in supersonic and hypersonic speeds, and disposed at 90.degree. for subsonic speeds encountered during entry. The oblique wing is driven axially and rotated by means of a turret mounted on rails.

  5. A two-stage monolithic buffer amplifier for 20 GHz satellite communication

    NASA Technical Reports Server (NTRS)

    Petersen, W. C.; Gupta, A. K.

    1983-01-01

    Design, fabrication, and test results of a two-stage GaAs monolithic buffer amplifier for 20 GHz satellite communication are described in this paper. A gain of 13 + or - 0.75 dB from 17.7 to 20.2 GHz was obtained from the 1.5 x 1.5 millimeter chip, which includes all necessary bias and dc blocking circuitry.

  6. High-pressure Experimental Studies on Geo-liquids Using Synchrotron Radiation at the Advanced Photon Source

    SciTech Connect

    Wang, Yanbin; Shen, Guoyin

    2014-12-23

    Here, we review recent progress in studying silicate, carbonate, and metallic liquids of geological and geophysical importance at high pressure and temperature, using the large-volume high-pressure devices at the third-generation synchrotron facility of the Advanced Photon Source, Argonne National Laboratory. These integrated high-pressure facilities now offer a unique combination of experimental techniques that allow researchers to investigate structure, density, elasticity, viscosity, and interfacial tension of geo-liquids under high pressure, in a coordinated and systematic fashion. Moreover, we describe experimental techniques, along with scientific highlights. Future developments are also discussed.

  7. Continuous removal of endocrine disruptors by versatile peroxidase using a two-stage system.

    PubMed

    Taboada-Puig, Roberto; Lu-Chau, Thelmo A; Eibes, Gemma; Feijoo, Gumersindo; Moreira, Maria T; Lema, Juan M

    2015-01-01

    The oxidant Mn(3+) -malonate, generated by the ligninolytic enzyme versatile peroxidase in a two-stage system, was used for the continuous removal of endocrine disrupting compounds (EDCs) from synthetic and real wastewaters. One plasticizer (bisphenol-A), one bactericide (triclosan) and three estrogenic compounds (estrone, 17β-estradiol, and 17α-ethinylestradiol) were removed from wastewater at degradation rates in the range of 28-58 µg/L·min, with low enzyme inactivation. First, the optimization of three main parameters affecting the generation of Mn(3+) -malonate (hydraulic retention time as well as Na-malonate and H2 O2 feeding rates) was conducted following a response surface methodology (RSM). Under optimal conditions, the degradation of the EDCs was proven at high (1.3-8.8 mg/L) and environmental (1.2-6.1 µg/L) concentrations. Finally, when the two-stage system was compared with a conventional enzymatic membrane reactor (EMR) using the same enzyme, a 14-fold increase of the removal efficiency was observed. At the same time, operational problems found during EDCs removal in the EMR system (e.g., clogging of the membrane and enzyme inactivation) were avoided by physically separating the stages of complex formation and pollutant oxidation, allowing the system to be operated for a longer period (∼8 h). This study demonstrates the feasibility of the two-stage enzymatic system for removing EDCs both at high and environmental concentrations.

  8. Two-stage solar concentrators based on parabolic troughs: asymmetric versus symmetric designs.

    PubMed

    Schmitz, Max; Cooper, Thomas; Ambrosetti, Gianluca; Steinfeld, Aldo

    2015-11-20

    While nonimaging concentrators can approach the thermodynamic limit of concentration, they generally suffer from poor compactness when designed for small acceptance angles, e.g., to capture direct solar irradiation. Symmetric two-stage systems utilizing an image-forming primary parabolic concentrator in tandem with a nonimaging secondary concentrator partially overcome this compactness problem, but their achievable concentration ratio is ultimately limited by the central obstruction caused by the secondary. Significant improvements can be realized by two-stage systems having asymmetric cross-sections, particularly for 2D line-focus trough designs. We therefore present a detailed analysis of two-stage line-focus asymmetric concentrators for flat receiver geometries and compare them to their symmetric counterparts. Exemplary designs are examined in terms of the key optical performance metrics, namely, geometric concentration ratio, acceptance angle, concentration-acceptance product, aspect ratio, active area fraction, and average number of reflections. Notably, we show that asymmetric designs can achieve significantly higher overall concentrations and are always more compact than symmetric systems designed for the same concentration ratio. Using this analysis as a basis, we develop novel asymmetric designs, including two-wing and nested configurations, which surpass the optical performance of two-mirror aplanats and are comparable with the best reported 2D simultaneous multiple surface designs for both hollow and dielectric-filled secondaries. PMID:26836527

  9. Study on two stage activated carbon/HFC-134a based adsorption chiller

    NASA Astrophysics Data System (ADS)

    >K Habib, M. Amin B. A.; Sulaiman, Shaharin Anwar B.

    2013-06-01

    In this paper, a theoretical analysis on the performance of a thermally driven two-stage four-bed adsorption chiller utilizing low-grade waste heat of temperatures between 50°C and 70°C in combination with a heat sink (cooling water) of 30°C for air-conditioning applications has been described. Activated carbon (AC) of type Maxsorb III/HFC-134a pair has been examined as an adsorbent/refrigerant pair. FORTRAN simulation program is developed to analyze the influence of operating conditions (hot and cooling water temperatures and adsorption/desorption cycle times) on the cycle performance in terms of cooling capacity and COP. The main advantage of this two-stage chiller is that it can be operational with smaller regenerating temperature lifts than other heat-driven single-stage chillers. Simulation results shows that the two-stage chiller can be operated effectively with heat sources of 50°C and 70°C in combination with a coolant at 30°C.

  10. Assessing efficiency and effectiveness of Malaysian Islamic banks: A two stage DEA analysis

    NASA Astrophysics Data System (ADS)

    Kamarudin, Norbaizura; Ismail, Wan Rosmanira; Mohd, Muhammad Azri

    2014-06-01

    Islamic banks in Malaysia are indispensable players in the financial industry with the growing needs for syariah compliance system. In the banking industry, most recent studies concerned only on operational efficiency. However rarely on the operational effectiveness. Since the production process of banking industry can be described as a two-stage process, two-stage Data Envelopment Analysis (DEA) can be applied to measure the bank performance. This study was designed to measure the overall performance in terms of efficiency and effectiveness of Islamic banks in Malaysia using Two-Stage DEA approach. This paper presents analysis of a DEA model which split the efficiency and effectiveness in order to evaluate the performance of ten selected Islamic Banks in Malaysia for the financial year period ended 2011. The analysis shows average efficient score is more than average effectiveness score thus we can say that Malaysian Islamic banks were more efficient rather than effective. Furthermore, none of the bank exhibit best practice in both stages as we can say that a bank with better efficiency does not always mean having better effectiveness at the same time.

  11. An efficient two-stage approach for image-based FSI analysis of atherosclerotic arteries

    PubMed Central

    Rayz, Vitaliy L.; Mofrad, Mohammad R. K.; Saloner, David

    2010-01-01

    Patient-specific biomechanical modeling of atherosclerotic arteries has the potential to aid clinicians in characterizing lesions and determining optimal treatment plans. To attain high levels of accuracy, recent models use medical imaging data to determine plaque component boundaries in three dimensions, and fluid–structure interaction is used to capture mechanical loading of the diseased vessel. As the plaque components and vessel wall are often highly complex in shape, constructing a suitable structured computational mesh is very challenging and can require a great deal of time. Models based on unstructured computational meshes require relatively less time to construct and are capable of accurately representing plaque components in three dimensions. These models unfortunately require additional computational resources and computing time for accurate and meaningful results. A two-stage modeling strategy based on unstructured computational meshes is proposed to achieve a reasonable balance between meshing difficulty and computational resource and time demand. In this method, a coarsegrained simulation of the full arterial domain is used to guide and constrain a fine-scale simulation of a smaller region of interest within the full domain. Results for a patient-specific carotid bifurcation model demonstrate that the two-stage approach can afford a large savings in both time for mesh generation and time and resources needed for computation. The effects of solid and fluid domain truncation were explored, and were shown to minimally affect accuracy of the stress fields predicted with the two-stage approach. PMID:19756798

  12. On efficient two-stage adaptive designs for clinical trials with sample size adjustment.

    PubMed

    Liu, Qing; Li, Gang; Anderson, Keaven M; Lim, Pilar

    2012-01-01

    Group sequential designs are rarely used for clinical trials with substantial over running due to fast enrollment or long duration of treatment and follow-up. Traditionally, such trials rely on fixed sample size designs. Recently, various two-stage adaptive designs have been introduced to allow sample size adjustment to increase statistical power or avoid unnecessarily large trials. However, these adaptive designs can be seriously inefficient. To address this infamous problem, we propose a likelihood-based two-stage adaptive design where sample size adjustment is derived from a pseudo group sequential design using cumulative conditional power. We show through numerical examples that this design cannot be improved by group sequential designs. In addition, the approach may uniformly improve any existing two-stage adaptive designs with sample size adjustment. For statistical inference, we provide methods for sequential p-values and confidence intervals, as well as median unbiased and minimum variance unbiased estimates. We show that the claim of inefficiency of adaptive designs by Tsiatis and Mehta ( 2003 ) is logically flawed, and thereby provide a strong defense of Cui et al. ( 1999 ). PMID:22651105

  13. Rehabilitation outcomes in patients with early and two-stage reconstruction of flexor tendon injuries

    PubMed Central

    Sade, Ilgin; İnanir, Murat; Şen, Suzan; Çakmak, Esra; Kablanoğlu, Serkan; Selçuk, Barin; Dursun, Nigar

    2016-01-01

    [Purpose] The primary aim of this study was to assess rehabilitation outcomes for early and two-stage repair of hand flexor tendon injuries. The secondary purpose of this study was to compare the findings between treatment groups. [Subjects and Methods] Twenty-three patients were included in this study. Early repair (n=14) and two-stage repair (n=9) groups were included in a rehabilitation program that used hand splints. This retrospective evaluated patients according to their demographic characteristics, including age, gender, injured hand, dominant hand, cause of injury, zone of injury, number of affected fingers, and accompanying injuries. Pain, range of motion, and grip strength were evaluated using a visual analog scale, goniometer, and dynamometer, respectively. [Results] Both groups showed significant improvements in pain and finger flexion after treatment compared with baseline measurements. However, no significant differences were observed between the two treatment groups. Similar results were obtained for grip strength and pinch grip, whereas gross grip was better in the early tendon repair group. [Conclusion] Early and two-stage reconstruction of patients with flexor tendon injuries can be performed with similarly favorable responses and effective rehabilitation programs.

  14. Novel two stage bio-oxidation and chlorination process for high strength hazardous coal carbonization effluent.

    PubMed

    Manekar, Pravin; Biswas, Rima; Karthik, Manikavasagam; Nandy, Tapas

    2011-05-15

    Effluent generated from coal carbonization to coke was characterized with high organic content, phenols, ammonium nitrogen, and cyanides. A full scale effluent treatment plant (ETP) working on the principle of single stage carbon-nitrogen bio-oxidation process (SSCNBP) revealed competition between heterotrophic and autotrophic bacteria in the bio-degradation and nitrification process. The effluent was pretreated in a stripper and further combined with other streams to treat in the SSCNBP. Laboratory studies were carried on process and stripped effluents in a bench scale model of ammonia stripper and a two stage bio-oxidation process. The free ammonia removal efficiency of stripper was in the range 70-89%. Bench scale studies of the two stage bio-oxidation process achieved a carbon-nitrogen reduction at 6 days hydraulic retention time (HRT) operating in an extended aeration mode. This paper addresses the studies on selection of a treatment process for removal of organic matter, phenols, cyanide and ammonia nitrogen. The treatment scheme comprising ammonia stripping (pretreatment) followed by the two stage bio-oxidation and chlorination process met the Indian Standards for discharge into Inland Surface Waters. This treatment process package offers a techno-economically viable treatment scheme to neuter hazardous effluent generated from coal carbonization process. PMID:21371822

  15. Two-stage solar concentrators based on parabolic troughs: asymmetric versus symmetric designs.

    PubMed

    Schmitz, Max; Cooper, Thomas; Ambrosetti, Gianluca; Steinfeld, Aldo

    2015-11-20

    While nonimaging concentrators can approach the thermodynamic limit of concentration, they generally suffer from poor compactness when designed for small acceptance angles, e.g., to capture direct solar irradiation. Symmetric two-stage systems utilizing an image-forming primary parabolic concentrator in tandem with a nonimaging secondary concentrator partially overcome this compactness problem, but their achievable concentration ratio is ultimately limited by the central obstruction caused by the secondary. Significant improvements can be realized by two-stage systems having asymmetric cross-sections, particularly for 2D line-focus trough designs. We therefore present a detailed analysis of two-stage line-focus asymmetric concentrators for flat receiver geometries and compare them to their symmetric counterparts. Exemplary designs are examined in terms of the key optical performance metrics, namely, geometric concentration ratio, acceptance angle, concentration-acceptance product, aspect ratio, active area fraction, and average number of reflections. Notably, we show that asymmetric designs can achieve significantly higher overall concentrations and are always more compact than symmetric systems designed for the same concentration ratio. Using this analysis as a basis, we develop novel asymmetric designs, including two-wing and nested configurations, which surpass the optical performance of two-mirror aplanats and are comparable with the best reported 2D simultaneous multiple surface designs for both hollow and dielectric-filled secondaries.

  16. Detection of microcalcifications ROI in digital mammograms using two stages of neural networks

    NASA Astrophysics Data System (ADS)

    Lee, Yang-suk; Lim, Seung-Chul; Park, Dong-Sun

    2001-09-01

    In this paper, we present an efficient algorithm to detect microcalcifications ROI (Regions of Interest) in digital mammograms using two stages of neural networks. To efficiently detect microcalcifications ROI, we used four sequential processes; preprocessing for breast area detection, modified multilevel thresholding, ROI selection using simple thresholding filters and final ROI selection with two stages of neural networks. In modified multilevel thresholding, the shape property of microcalcification resulted from the gray-level difference with surroundings is used. This algorithm separates microcalcifications from tissues by applying the half-toning technique for different gray-levels. The first selection process with simple thresholding filters defines the filter parameters using the statistically extracted shape property and then it eliminates tissues, which are obviously recognized, to reduce the processing overhead in the next step. The final selection process using neural networks is to detect the ROI in two steps. Through the two stages of neural networks, ROIs with microcalcifications are selected. Each neural network compares and analyzes recognition performance after training. The ROI detection method for microcalcification used in this paper is the first stage for a CAD system. The designed ROI detection methods efficiently find 98.06% of with microcalcifications.

  17. Research on a novel two-stage direct current hybrid circuit breaker.

    PubMed

    Wu, Yifei; Wu, Yi; Rong, Mingzhe; Yang, Fei; Niu, Chunping; Li, Mei; Hu, Yang

    2014-08-01

    The DC hybrid circuit breaker based on high-speed switch (HSS) and parallel connected capacitor has been widely applied in the fault current breaking of DC system. However, when the current is commutated from HSS to the capacitor according to single-stage operation, the capacitor has to absorb a large amount of energy stored in the system inductance within very short time. Meanwhile, a high over-voltage rate of rise is especially prone to be produced between the contacts of HSS, which will lead to a failed breaking. As a result, a novel DC hybrid circuit breaker based on the two-stage operation is proposed and analyzed in this paper. By controlling the thyristors in the commutation branches, the fault current is fast commutated into the capacitor, which can not only realize the arcless open of HSS, but also decrease the over-voltage rate of rise significantly in comparison to the traditional single-stage operation. The simulation model of fault current breaking under different conditions in 10 kV medium voltage DC system is constructed. The simulated over-voltages of single-stage and two-stage operations in the case of fault current breaking are compared and analyzed. Finally, the fault current breaking test in the two-stage operation is investigated experimentally, which validates the feasibility and effectiveness of the simulation model well.

  18. Research on a novel two-stage direct current hybrid circuit breaker

    NASA Astrophysics Data System (ADS)

    Wu, Yifei; Wu, Yi; Rong, Mingzhe; Yang, Fei; Niu, Chunping; Li, Mei; Hu, Yang

    2014-08-01

    The DC hybrid circuit breaker based on high-speed switch (HSS) and parallel connected capacitor has been widely applied in the fault current breaking of DC system. However, when the current is commutated from HSS to the capacitor according to single-stage operation, the capacitor has to absorb a large amount of energy stored in the system inductance within very short time. Meanwhile, a high over-voltage rate of rise is especially prone to be produced between the contacts of HSS, which will lead to a failed breaking. As a result, a novel DC hybrid circuit breaker based on the two-stage operation is proposed and analyzed in this paper. By controlling the thyristors in the commutation branches, the fault current is fast commutated into the capacitor, which can not only realize the arcless open of HSS, but also decrease the over-voltage rate of rise significantly in comparison to the traditional single-stage operation. The simulation model of fault current breaking under different conditions in 10 kV medium voltage DC system is constructed. The simulated over-voltages of single-stage and two-stage operations in the case of fault current breaking are compared and analyzed. Finally, the fault current breaking test in the two-stage operation is investigated experimentally, which validates the feasibility and effectiveness of the simulation model well.

  19. High quantum efficiency mid-wavelength interband cascade infrared photodetectors with one and two stages

    NASA Astrophysics Data System (ADS)

    Zhou, Yi; Chen, Jianxin; Xu, Zhicheng; He, Li

    2016-08-01

    In this paper, we report on mid-wavelength infrared interband cascade photodetectors grown on InAs substrates. We studied the transport properties of the photon-generated carriers in the interband cascade structures by comparing two different detectors, a single stage detector and a two-stage cascade detector. The two-stage device showed quantum efficiency around 19.8% at room temperature, and clear optical response was measured even at a temperature of 323 K. The two detectors showed similar Johnson-noise limited detectivity. The peak detectivity of the one- and two-stage devices was measured to be 2.15 × 1014 cm·Hz1/02/W and 2.19 × 1014 cm·Hz1/02/W at 80 K, 1.21 × 109 cm·Hz1/02/W and 1.23 × 109 cm·Hz1/02/W at 300 K, respectively. The 300 K background limited infrared performance (BLIP) operation temperature is estimated to be over 140 K.

  20. Rehabilitation outcomes in patients with early and two-stage reconstruction of flexor tendon injuries

    PubMed Central

    Sade, Ilgin; İnanir, Murat; Şen, Suzan; Çakmak, Esra; Kablanoğlu, Serkan; Selçuk, Barin; Dursun, Nigar

    2016-01-01

    [Purpose] The primary aim of this study was to assess rehabilitation outcomes for early and two-stage repair of hand flexor tendon injuries. The secondary purpose of this study was to compare the findings between treatment groups. [Subjects and Methods] Twenty-three patients were included in this study. Early repair (n=14) and two-stage repair (n=9) groups were included in a rehabilitation program that used hand splints. This retrospective evaluated patients according to their demographic characteristics, including age, gender, injured hand, dominant hand, cause of injury, zone of injury, number of affected fingers, and accompanying injuries. Pain, range of motion, and grip strength were evaluated using a visual analog scale, goniometer, and dynamometer, respectively. [Results] Both groups showed significant improvements in pain and finger flexion after treatment compared with baseline measurements. However, no significant differences were observed between the two treatment groups. Similar results were obtained for grip strength and pinch grip, whereas gross grip was better in the early tendon repair group. [Conclusion] Early and two-stage reconstruction of patients with flexor tendon injuries can be performed with similarly favorable responses and effective rehabilitation programs. PMID:27630400

  1. Effects of earthworm casts and zeolite on the two-stage composting of green waste

    SciTech Connect

    Zhang, Lu Sun, Xiangyang

    2015-05-15

    Highlights: • Earthworm casts (EWCs) and clinoptilolite (CL) were used in green waste composting. • Addition of EWCs + CL improved physico-chemical and microbiological properties. • Addition of EWCs + CL extended the duration of thermophilic periods during composting. • Addition of EWCs + CL enhanced humification, cellulose degradation, and nutrients. • Combined addition of 0.30% EWCs + 25% CL reduced composting time to 21 days. - Abstract: Because it helps protect the environment and encourages economic development, composting has become a viable method for organic waste disposal. The objective of this study was to investigate the effects of earthworm casts (EWCs) (at 0.0%, 0.30%, and 0.60%) and zeolite (clinoptilolite, CL) (at 0%, 15%, and 25%) on the two-stage composting of green waste. The combination of EWCs and CL improved the conditions of the composting process and the quality of the compost products in terms of the thermophilic phase, humification, nitrification, microbial numbers and enzyme activities, the degradation of cellulose and hemicellulose, and physico-chemical characteristics and nutrient contents of final composts. The compost matured in only 21 days with the optimized two-stage composting method rather than in the 90–270 days required for traditional composting. The optimal two-stage composting and the best quality compost were obtained with 0.30% EWCs and 25% CL.

  2. Development of Two-Stage Stirling Cooler for ASTRO-F

    NASA Astrophysics Data System (ADS)

    Narasaki, K.; Tsunematsu, S.; Ootsuka, K.; Kyoya, M.; Matsumoto, T.; Murakami, H.; Nakagawa, T.

    2004-06-01

    A two-stage small Stirling cooler has been developed and tested for the infrared astronomical satellite ASTRO-F that is planned to be launched by Japanese M-V rocket in 2005. ASTRO-F has a hybrid cryogenic system that is a combination of superfluid liquid helium (HeII) and two-stage Stirling coolers. The mechanical cooler has a two-stage displacer driven by a linear motor in a cold head and a new linear-ball-bearing system for the piston-supporting structure in a compressor. The linear-ball-bearing supporting system achieves the piston clearance seal, the long piston-stroke operation and the low frequency operation. The typical cooling power is 200 mW at 20 K and the total input power to the compressor and the cold head is below 90 W without driver electronics. The engineering, the prototype and the flight models of the cooler have been fabricated and evaluated to verify the capability for ASTRO-F. This paper describes the design of the cooler and the results from verification tests including cooler performance test, thermal vacuum test, vibration test and lifetime test.

  3. Industrial demonstration plant for the gasification of herb residue by fluidized bed two-stage process.

    PubMed

    Zeng, Xi; Shao, Ruyi; Wang, Fang; Dong, Pengwei; Yu, Jian; Xu, Guangwen

    2016-04-01

    A fluidized bed two-stage gasification process, consisting of a fluidized-bed (FB) pyrolyzer and a transport fluidized bed (TFB) gasifier, has been proposed to gasify biomass for fuel gas production with low tar content. On the basis of our previous fundamental study, an autothermal two-stage gasifier has been designed and built for gasify a kind of Chinese herb residue with a treating capacity of 600 kg/h. The testing data in the operational stable stage of the industrial demonstration plant showed that when keeping the reaction temperatures of pyrolyzer and gasifier respectively at about 700 °C and 850 °C, the heating value of fuel gas can reach 1200 kcal/Nm(3), and the tar content in the produced fuel gas was about 0.4 g/Nm(3). The results from this pilot industrial demonstration plant fully verified the feasibility and technical features of the proposed FB two-stage gasification process.

  4. Performance analysis of RDF gasification in a two stage fluidized bed-plasma process.

    PubMed

    Materazzi, M; Lettieri, P; Taylor, R; Chapman, C

    2016-01-01

    The major technical problems faced by stand-alone fluidized bed gasifiers (FBG) for waste-to gas applications are intrinsically related to the composition and physical properties of waste materials, such as RDF. The high quantity of ash and volatile material in RDF can provide a decrease in thermal output, create high ash clinkering, and increase emission of tars and CO2, thus affecting the operability for clean syngas generation at industrial scale. By contrast, a two-stage process which separates primary gasification and selective tar and ash conversion would be inherently more forgiving and stable. This can be achieved with the use of a separate plasma converter, which has been successfully used in conjunction with conventional thermal treatment units, for the ability to 'polish' the producer gas by organic contaminants and collect the inorganic fraction in a molten (and inert) state. This research focused on the performance analysis of a two-stage fluid bed gasification-plasma process to transform solid waste into clean syngas. Thermodynamic assessment using the two-stage equilibrium method was carried out to determine optimum conditions for the gasification of RDF and to understand the limitations and influence of the second stage on the process performance (gas heating value, cold gas efficiency, carbon conversion efficiency), along with other parameters. Comparison with a different thermal refining stage, i.e. thermal cracking (via partial oxidation) was also performed. The analysis is supported by experimental data from a pilot plant.

  5. Performance analysis of RDF gasification in a two stage fluidized bed-plasma process.

    PubMed

    Materazzi, M; Lettieri, P; Taylor, R; Chapman, C

    2016-01-01

    The major technical problems faced by stand-alone fluidized bed gasifiers (FBG) for waste-to gas applications are intrinsically related to the composition and physical properties of waste materials, such as RDF. The high quantity of ash and volatile material in RDF can provide a decrease in thermal output, create high ash clinkering, and increase emission of tars and CO2, thus affecting the operability for clean syngas generation at industrial scale. By contrast, a two-stage process which separates primary gasification and selective tar and ash conversion would be inherently more forgiving and stable. This can be achieved with the use of a separate plasma converter, which has been successfully used in conjunction with conventional thermal treatment units, for the ability to 'polish' the producer gas by organic contaminants and collect the inorganic fraction in a molten (and inert) state. This research focused on the performance analysis of a two-stage fluid bed gasification-plasma process to transform solid waste into clean syngas. Thermodynamic assessment using the two-stage equilibrium method was carried out to determine optimum conditions for the gasification of RDF and to understand the limitations and influence of the second stage on the process performance (gas heating value, cold gas efficiency, carbon conversion efficiency), along with other parameters. Comparison with a different thermal refining stage, i.e. thermal cracking (via partial oxidation) was also performed. The analysis is supported by experimental data from a pilot plant. PMID:26184896

  6. Industrial demonstration plant for the gasification of herb residue by fluidized bed two-stage process.

    PubMed

    Zeng, Xi; Shao, Ruyi; Wang, Fang; Dong, Pengwei; Yu, Jian; Xu, Guangwen

    2016-04-01

    A fluidized bed two-stage gasification process, consisting of a fluidized-bed (FB) pyrolyzer and a transport fluidized bed (TFB) gasifier, has been proposed to gasify biomass for fuel gas production with low tar content. On the basis of our previous fundamental study, an autothermal two-stage gasifier has been designed and built for gasify a kind of Chinese herb residue with a treating capacity of 600 kg/h. The testing data in the operational stable stage of the industrial demonstration plant showed that when keeping the reaction temperatures of pyrolyzer and gasifier respectively at about 700 °C and 850 °C, the heating value of fuel gas can reach 1200 kcal/Nm(3), and the tar content in the produced fuel gas was about 0.4 g/Nm(3). The results from this pilot industrial demonstration plant fully verified the feasibility and technical features of the proposed FB two-stage gasification process. PMID:26849201

  7. Prediction of Unsteady Blade Surface Pressures on an Advanced Propeller at an Angle of Attack

    NASA Technical Reports Server (NTRS)

    Nallasamy, M.; Groeneweg, J. F.

    1989-01-01

    The numerical solution of the unsteady, three-dimensional, Euler equations is considered in order to obtain the blade surface pressures of an advanced propeller at an angle of attack. The specific configuration considered is the SR7L propeller at cruise conditions with a 4.6 deg inflow angle corresponding to the plus 2 deg nacelle tilt of the Propeller Test Assessment (PTA) flight test condition. The results indicate nearly sinusoidal response of the blade loading, with angle of attack. For the first time, detailed variations of the chordwise loading as a function of azimuthal angle are presented. It is observed that the blade is lightly loaded for part of the revolution and shocks appear from hub to about 80 percent radial station for the highly loaded portion of the revolution.

  8. An advanced solid state pressure transducer for high reliability SSME application

    NASA Technical Reports Server (NTRS)

    Johnson, R. L.; Wamstad, D. B.

    1985-01-01

    New methods to advance the state-of-the-art of pressure sensors for the Space Shuttle Main Engine were demonstrated. The results of the feasibility and breadboard demonstration phase and the current status of the research development prototype follow-on phase are presented. A technology breakthrough utilizing silicon piezoresistive technology was achieved in the first phase. A transducer design concept for the SSME application utilizes packaging materials with similar thermal coefficients of expansion and maintains the transducer seals primarily in compression. The silicon chip design will provide dual sensing outputs with laser trimmable integrated compensating electronics. The silicon resistor ion implant dose was customized for the SSME temperature requirement. A basic acoustic modeling software program was developed to evaluate the frequency response characteristics for the package design.

  9. Optical Fuel Injector Patternation Measurements in Advanced Liquid-Fueled, High Pressure, Gas Turbine Combustors

    NASA Technical Reports Server (NTRS)

    Locke, R. J.; Hicks, Y. R.; Anderson, R. C.; Zaller, M. M.

    1998-01-01

    Planar laser-induced fluorescence (PLIF) imaging and planar Mie scattering are used to examine the fuel distribution pattern (patternation) for advanced fuel injector concepts in kerosene burning, high pressure gas turbine combustors. Three fuel injector concepts for aerospace applications were investigated under a broad range of operating conditions. Fuel PLIF patternation results are contrasted with those obtained by planar Mie scattering. For one injector, further comparison is also made with data obtained through phase Doppler measurements. Differences in spray patterns for diverse conditions and fuel injector configurations are readily discernible. An examination of the data has shown that a direct determination of the fuel spray angle at realistic conditions is also possible. The results obtained in this study demonstrate the applicability and usefulness of these nonintrusive optical techniques for investigating fuel spray patternation under actual combustor conditions.

  10. Of mice and men: a critical reappraisal of the two-stage theory of carcinogenesis.

    PubMed

    Iversen, O H

    1995-01-01

    The two-stage theory of carcinogenesis attempts to reduce a very complex set of data to simple terms: it defines a carcinogen as "an agent that causes a neoplasm by a two-step process involving initiation and promotion". The theory has achieved the status of a paradigm, and all new experiments carried out by two-stage supporters are designed according to its premises and therefore will eo ipso tend to confirm it. Popper's dictum that any scientific hypothesis should be put to the strongest test, namely, by trying to refute it, has rarely (or never) been observed. The two-stage theory was originally based on standard mouse skin-painting experiments. All the original work is grounded on classic skin carcinogenesis, and only later was it extended to also comprise carcinogenesis in other organs, thereby becoming a general theory. On the basis of the same standard skin painting experiments and in accordance with Popper's dictum, the present review shows how the following generally accepted corollaries of the two-stage theory have been refuted: initiation must come first in time; in previously initiated mouse skin promotion always leads to a synergistic increase in tumor crop, whereas complete carcinogens at subthreshold does (regarded as merely initiating) have only an additive effect; the reverse experiment is innocuous; there is a qualitative difference between the effect of initiators and that of promoters; initiators only initiate at low dose levels, but abruptly become rather complete carcinogens at higher doses, promotion must take place over a long period, and repeated exposure without prolonged intervals is essential; pure initiators exist, for example, urethane for the epidermis; pure promoters exist, e.g., TPA; skin inflammation and persistent hyperplasia are essential parts of promotion; increased levels of the enzyme ODC followed by increasing levels of polyamines are casually involved in promotion; the appearance of many dark epidermal cells is a sign of

  11. Empirical study of classification process for two-stage turbo air classifier in series

    NASA Astrophysics Data System (ADS)

    Yu, Yuan; Liu, Jiaxiang; Li, Gang

    2013-05-01

    The suitable process parameters for a two-stage turbo air classifier are important for obtaining the ultrafine powder that has a narrow particle-size distribution, however little has been published internationally on the classification process for the two-stage turbo air classifier in series. The influence of the process parameters of a two-stage turbo air classifier in series on classification performance is empirically studied by using aluminum oxide powders as the experimental material. The experimental results show the following: 1) When the rotor cage rotary speed of the first-stage classifier is increased from 2 300 r/min to 2 500 r/min with a constant rotor cage rotary speed of the second-stage classifier, classification precision is increased from 0.64 to 0.67. However, in this case, the final ultrafine powder yield is decreased from 79% to 74%, which means the classification precision and the final ultrafine powder yield can be regulated through adjusting the rotor cage rotary speed of the first-stage classifier. 2) When the rotor cage rotary speed of the second-stage classifier is increased from 2 500 r/min to 3 100 r/min with a constant rotor cage rotary speed of the first-stage classifier, the cut size is decreased from 13.16 μm to 8.76 μm, which means the cut size of the ultrafine powder can be regulated through adjusting the rotor cage rotary speed of the second-stage classifier. 3) When the feeding speed is increased from 35 kg/h to 50 kg/h, the "fish-hook" effect is strengthened, which makes the ultrafine powder yield decrease. 4) To weaken the "fish-hook" effect, the equalization of the two-stage wind speeds or the combination of a high first-stage wind speed with a low second-stage wind speed should be selected. This empirical study provides a criterion of process parameter configurations for a two-stage or multi-stage classifier in series, which offers a theoretical basis for practical production.

  12. Preliminary fracture analysis of the core pressure boundary tube for the Advanced Neutron Source Research Reactor

    SciTech Connect

    Schulz, K.C.; Yahr, G.T.

    1995-08-01

    The outer core pressure boundary tube (CPBT) of the Advanced neutron Source (ANS) reactor being designed at Oak Ridge National Laboratory is currently specified as being composed of 6061-T6 aluminum. ASME Boiler and Pressure Vessel Code fracture analysis rules for nuclear components are based on the use of ferritic steels; the expressions, tables, charts and equations were all developed from tests and analyses conducted for ferritic steels. Because of the nature of the Code, design with thin aluminum requires analytical approaches that do not directly follow the Code. The intent of this report is to present a methodology comparable to the ASME Code for ensuring the prevention of nonductile fracture of the CPBT in the ANS reactor. 6061-T6 aluminum is known to be a relatively brittle material; the linear elastic fracture mechanics (LEFM) approach is utilized to determine allowable flaw sizes for the CPBT. A J-analysis following the procedure developed by the Electric Power Research Institute was conducted as a check; the results matched those for the LEFM analysis for the cases analyzed. Since 6061-T6 is known to embrittle when irradiated, the reduction in K{sub Q} due to irradiation is considered in the analysis. In anticipation of probable requirements regarding maximum allowable flaw size, a survey of nondestructive inspection capabilities is also presented. A discussion of probabilistic fracture mechanics approaches, principally Monte Carlo techniques, is included in this report as an introduction to what quantifying the probability of nonductile failure of the CPBT may entail.

  13. Two-stage fan. 2: Data and performance with redesigned second stage rotor uniform and distorted inlet flows

    NASA Technical Reports Server (NTRS)

    Messenger, H. E.; Keenan, M. J.

    1974-01-01

    A two-stage fan with a first rotor tip speed of 1450 ft/sec (441.96 m/sec) and no inlet guide vanes was tested with uniform and distorted inlet flows, with a redesigned second rotor having a part span shroud to prevent flutter, with variable-stagger stators set in nominal positions, and without rotor casing treatment. The fan achieved a pressure ratio 2.8 at a corrected flow of 185.4 lbm/sec (84.0 kg/sec), an adiabatic efficiency of 85.0 percent, and a stall margin of 12 percent. The redesigned second rotor did not flutter. Tip radial distortion reduced the stall margin at intermediate speed, but had little effect on stall margin at high or low speeds. Hub radial distortion reduced the stall margin at design speed but increased stall margin at low speed. Circumferential distortion reduced stall pressure ratio and flow to give approximately the same stall lines with uniform inlet flow. Distortions were attenuated by the fan. For Vol. 1, see N74-11421.

  14. Operating characteristics of a 7. 6 mm (0. 30 inch) diameter two-stage light-gas gun

    SciTech Connect

    Susoeff, A R; Hawke, R S; Bowen, P R; Greenwood, D W; Marshall, F R

    1992-07-01

    a series of tests was conducted to determine the operating requirements needed to obtain maximum projectile velocity within the engineering design limits of a two-stage light-gas gun with a 7.6 mm (0.30 inch) diameter bore launch tube. The tests were conducted in a medium vacuum flight range. Previous experience with the gun was used to establish the minimum requirements for optimum efficiency. Two operating parameters, propellant load and drive gas pressure, were varied in order to find an initial optimum operating condition at a conservative propellant load. Propellant load and driver gas pressure were then incrementally increased. This procedure was methodically applied until significant mechanical deformation of a critical gun component took place. This report presents the results of these tests. Projectile velocity was measured to better than 3 percent accuracy using a magnetic induction technique. A 0.485 gram polycarbonate projectile was launched to a velocity of 7.77 km/s during the tests. 13 refs.

  15. Super blue box recycling (SUBBOR) enhanced two-stage anaerobic digestion process for recycling municipal solid waste: laboratory pilot studies.

    PubMed

    Vogt, G M; Liu, H W; Kennedy, K J; Vogt, H S; Holbein, B E

    2002-12-01

    The super blue box recycling (SUBBOR) process is an enhanced, multi-stage anaerobic digestion process for mixed municipal solid waste (MSW) and other biomass feedstock materials. The technology centers on enhanced high solids, thermophilic digestion after steam-pressure disruption of the ligno-cellulosic fiber components that are recalcitrant to conventional anaerobic digestion. Mixed MSW, rich in organic components but also containing inorganic materials, such as glass, aluminum and steel, as well as non-digestible plastic materials, has been laboratory pilot tested with a fully integrated process train designed to treat and recycle all of the MSW components. Methane yields from the MSW were 0.36 m3 CH4/kg volatile solids (VS) representing a 40% increase over the yield obtained from conventional single stage digestion. The secondary digestion step after steam pressure disruption also provided a 40% improvement in total solids and VS reduction. The residual organic fraction following two-stage digestion was fine in texture and was recovered as a clean peat fraction with reduced contents of heavy metal and other fugitive non-digested contaminants. Mass and energy balance determinations indicated a high degree of MSW diversion from landfill disposal (>80%) was achievable by the SUBBOR process as well as substantial net electrical and thermal energy production. Continuous long-term trials of the SUBBOR process at 25,000 tonnes/year are underway.

  16. Thiol-vinyl systems as shape memory polymers and novel two-stage reactive polymer systems

    NASA Astrophysics Data System (ADS)

    Nair, Devatha P.

    2011-12-01

    The focus of this research was to formulate, characterize and tailor the reaction methodologies and material properties of thiol-vinyl systems to develop novel polymer platforms for a range of engineering applications. Thiol-ene photopolymers were demonstrated to exhibit several advantageous characteristics for shape memory polymer systems for a range of biomedical applications. The thiol-ene shape memory polymer systems were tough and flexible as compared to the acrylic control systems with glass transition temperatures between 30 and 40 °C; ideal for actuation at body temperature. The thiol-ene polymers also exhibited excellent shape fixity and a rapid and distinct shape memory actuation response along with free strain recoveries of greater than 96% and constrained stress recoveries of 100%. Additionally, two-stage reactive thiol-acrylate systems were engineered as a polymer platform technology enabling two independent sets of polymer processing and material properties. There are distinct advantages to designing polymer systems that afford two distinct sets of material properties -- an intermediate polymer that would enable optimum handling and processing of the material (stage 1), while maintaining the ability to tune in different, final properties that enable the optimal functioning of the polymeric material (stage 2). To demonstrate the range of applicability of the two-stage reactive systems, three specific applications were demonstrated; shape memory polymers, lithographic impression materials, and optical materials. The thiol-acrylate reactions exhibit a wide range of application versatility due to the range of available thiol and acrylate monomers as well as reaction mechanisms such as Michael Addition reactions and free radical polymerizations. By designing a series of non-stoichiometeric thiol-acrylate systems, a polymer network is initially formed via a base catalyzed 'click' Michael addition reaction. This self-limiting reaction results in a Stage 1

  17. Advanced Concepts for Pressure-Channel Reactors: Modularity, Performance and Safety

    NASA Astrophysics Data System (ADS)

    Duffey, Romney B.; Pioro, Igor L.; Kuran, Sermet

    Based on an analysis of the development of advanced concepts for pressure-tube reactor technology, we adapt and adopt the pressure-tube reactor advantage of modularity, so that the subdivided core has the potential for optimization of the core, safety, fuel cycle and thermal performance independently, while retaining passive safety features. In addition, by adopting supercritical water-cooling, the logical developments from existing supercritical turbine technology and “steam” systems can be utilized. Supercritical and ultra-supercritical boilers and turbines have been operating for some time in coal-fired power plants. Using coolant outlet temperatures of about 625°C achieves operating plant thermal efficiencies in the order of 45-48%, using a direct turbine cycle. In addition, by using reheat channels, the plant has the potential to produce low-cost process heat, in amounts that are customer and market dependent. The use of reheat systems further increases the overall thermal efficiency to 55% and beyond. With the flexibility of a range of plant sizes suitable for both small (400 MWe) and large (1400 MWe) electric grids, and the ability for co-generation of electric power, process heat, and hydrogen, the concept is competitive. The choice of core power, reheat channel number and exit temperature are all set by customer and materials requirements. The pressure channel is a key technology that is needed to make use of supercritical water (SCW) in CANDU®1 reactors feasible. By optimizing the fuel bundle and fuel channel, convection and conduction assure heat removal using passive-moderator cooling. Potential for severe core damage can be almost eliminated, even without the necessity of activating the emergency-cooling systems. The small size of containment structure lends itself to a small footprint, impacts economics and building techniques. Design features related to Canadian concepts are discussed in this paper. The main conclusion is that development of

  18. Murine susceptibility to two-stage skin carcinogenesis is influenced by the agent used for promotion

    SciTech Connect

    Reiners, J.J. Jr.; Nesnow, S.; Slaga, T.J.

    1984-01-01

    Several approaches were employed to investigate whether murine stock and strain differences in susceptibility to two-stage skin carcinogenesis are due to differences in the metabolism of the initiating aromatic hydrocarbons, or the consequences of the agents used for promotion. A cell-mediated mutagenesis assay was used to quantitatively compare the abilities of cultured newborn SENCAR, DBA/2, C57BL/6 and BALB/c keratinocytes to metabolize dimethylbenz(a)anthracene (DMBA) to mutagenic and cytotoxic metabolites. At equivalent concentrations of DMBA, throughout a 25-fold range in promutagen concentration, C57BL/6, BALB/c and SENCAR keratinocyte-dependent mutant frequencies were very similar and approximately twice DBA/2 keratinocyte-dependent mutant frequencies. In in vivo tumor studies, C57BL/6 mice were more sensitive than SENCAR mice to complete skin carcinogenesis protocols employing repetitive weekly treatments with DMBA and benzo(a)pyrene (BP). At equivalent concentrations of either DMBA or BP, C57BL/6 mice developed carcinomas sooner, and had a greater number of carcinomas per animal. SENCAR mice were very sensitive to two-stage skin carcinogenesis protocols employing BP and DMBA as initiators and benzoyl peroxide and 12-O-tetradecanoylphorbol-13-acetate (TPA) as promoters. C57BL/6 mice were relatively refractory to TPA promotion but sensitive to promotion with benzoyl peroxide. These findings suggest that murine stock and strain-dependent differences in sensitivity to two-stage skin carcinogenesis may not be due to major differences in the metabolism of the initiating hydrocarbons, but are partially the consequences of the agents for promotion. 24 references, 5 figures, 1 table.

  19. Delayed two-stage breast reconstruction with implants: The authors’ recent experience

    PubMed Central

    Rykała, Jan; Szychta, Paweł; Kruk-Jeromin, Julia

    2011-01-01

    BACKGROUND: Presently, breast cancer detection is delayed in Poland and, thus, the only other option for patients is amputation and breast reconstruction (immediate or delayed). Reconstructive methods are based on using the patient’s own tissue (pedicled or free myocutaneous flaps) or implants (a tissue expander, which is later exchanged for a prosthesis or an expandable implant). OBJECTIVE: To evaluate the aesthetic results of a delayed two-stage breast reconstruction with the use of implants (expander and prosthesis) in patients who have previously undergone cancer-related mastectomy. METHODS: From 2006 to 2009, 54 patients (34 to 65 years of age) underwent reconstruction at least one year after their mastectomy and adjuvant chemotherapy; three women also received x-ray therapy. All women underwent a two-stage treatment with a tissue expander, which was later exchanged for a prosthesis. RESULTS: Outcomes of the surgery (evaluated by the physician and the patient at least six months after all stages of reconstruction) were found to be very good in 42 patients and good in 12 patients. After amputation and x-ray therapy in two cases, a fistula developed, which necessitated implant removal. CONCLUSIONS: After amputation, breast reconstruction with implants (expander and prosthesis) provides good aesthetic results. The method is mildly burdening to the patient and does not cause severe scarring. Symmetrization of the second breast is often recommended; however, the cost is not covered by the national health system. In principle, earlier x-ray therapy disqualifies the application of implants. Dividing reconstruction into two stages (expander and prosthesis) allows for possible correction of prosthesis placement. PMID:22942657

  20. Two-Stage Two-Locus Models in Genome-Wide Association

    PubMed Central

    Evans, David M; Marchini, Jonathan; Morris, Andrew P; Cardon, Lon R

    2006-01-01

    Studies in model organisms suggest that epistasis may play an important role in the etiology of complex diseases and traits in humans. With the era of large-scale genome-wide association studies fast approaching, it is important to quantify whether it will be possible to detect interacting loci using realistic sample sizes in humans and to what extent undetected epistasis will adversely affect power to detect association when single-locus approaches are employed. We therefore investigated the power to detect association for an extensive range of two-locus quantitative trait models that incorporated varying degrees of epistasis. We compared the power to detect association using a single-locus model that ignored interaction effects, a full two-locus model that allowed for interactions, and, most important, two two-stage strategies whereby a subset of loci initially identified using single-locus tests were analyzed using the full two-locus model. Despite the penalty introduced by multiple testing, fitting the full two-locus model performed better than single-locus tests for many of the situations considered, particularly when compared with attempts to detect both individual loci. Using a two-stage strategy reduced the computational burden associated with performing an exhaustive two-locus search across the genome but was not as powerful as the exhaustive search when loci interacted. Two-stage approaches also increased the risk of missing interacting loci that contributed little effect at the margins. Based on our extensive simulations, our results suggest that an exhaustive search involving all pairwise combinations of markers across the genome might provide a useful complement to single-locus scans in identifying interacting loci that contribute to moderate proportions of the phenotypic variance. PMID:17002500

  1. Two-stage continuous fermentation of Saccharomycopsis fibuligera and Candida utilis

    SciTech Connect

    Admassu, W.; Korus, R.A.; Heimsch, R.C.

    1983-11-01

    Biomass production and carbohydrate reduction were determined for a two-stage continuous fermentation process with a simulated potato processing waste feed. The amylolytic yeast Saccharomycopsis fibuligera was grown in the first stage and a mixed culture of S. fibuligera and Candida utilis was maintained in the second stage. All conditions for the first and second stages were fixed except the flow of medium to the second stage was varied. Maximum biomass production occurred at a second stage dilution rate, D2, of 0.27/h. Carbohydrate reduction was inversely proportional to D2 between 0.10 and 0.35/h. (Refs. 18).

  2. Two-stage bulk electron heating in the diffusion region of anti-parallel symmetric reconnection

    NASA Astrophysics Data System (ADS)

    Le, A.; Egedal, J.; Daughton, W.

    2016-10-01

    Electron bulk energization in the diffusion region during anti-parallel symmetric reconnection entails two stages. First, the inflowing electrons are adiabatically trapped and energized by an ambipolar parallel electric field. Next, the electrons gain energy from the reconnection electric field as they undergo meandering motion. These collisionless mechanisms have been described previously, and they lead to highly structured electron velocity distributions. Nevertheless, a simplified control-volume analysis gives estimates for how the net effective heating scales with the upstream plasma conditions in agreement with fully kinetic simulations and spacecraft observations.

  3. Use of two-stage membrane countercurrent cascade for natural gas purification from carbon dioxide

    NASA Astrophysics Data System (ADS)

    Kurchatov, I. M.; Laguntsov, N. I.; Karaseva, M. D.

    2016-09-01

    Membrane technology scheme is offered and presented as a two-stage countercurrent recirculating cascade, in order to solve the problem of natural gas dehydration and purification from CO2. The first stage is a single divider, and the second stage is a recirculating two-module divider. This scheme allows natural gas to be cleaned from impurities, with any desired degree of methane extraction. In this paper, the optimal values of the basic parameters of the selected technological scheme are determined. An estimation of energy efficiency was carried out, taking into account the energy consumption of interstage compressor and methane losses in energy units.

  4. Performance of two-stage fan having low-aspect-ratio first-stage rotor blading

    NASA Technical Reports Server (NTRS)

    Urasek, D. C.; Gorrell, W. T.; Cunnan, W. S.

    1979-01-01

    The NASA two stage fan was tested with a low aspect ratio first stage rotor having no midspan dampers. At design speed the fan achieved an adiabatic design efficiency of 0.846, and peak efficiencies for the first stage and rotor of 0.870 and 0.906, respectively. Peak efficiency occurred very close to the stall line. In an attempt to improve stall margin, the fan was retested with circumferentially grooved casing treatment and with a series of stator blade resets. Results showed no improvement in stall margin with casing treatment but increased to 8 percent with stator blade reset.

  5. Correlates of suicide and violence risk: III. A two-stage model of countervailing forces.

    PubMed

    Plutchik, R; van Praag, H M; Conte, H R

    1989-05-01

    Questionnaires and self-report scales were administered to 100 psychiatric inpatients. The scales measured such variables as depression, hopelessness, impulsivity, mental and life problems, family violence, personality characteristics, and dyscontrol tendencies. These were correlated with indices of suicide risk and violence risk. Most variables were found to correlate significantly with both suicide and violence risk. Partial correlation analyses revealed that 10 variables correlated significantly with suicide risk but not violence risk, while four variables correlated significantly with violence risk but not suicide risk. A two-stage model of countervailing forces, incorporating concepts from both psychoanalysis and ethology, is presented as a way of interpreting the results. PMID:2748772

  6. Two-dimensional object recognition through two-stage string matching.

    PubMed

    Wu, W Y; Wang, M J

    1999-01-01

    A two-stage string matching method for the recognition of two-dimensional (2-D) objects is proposed in this work. The first stage is a global cyclic string matching. The second stage is a local matching with local dissimilarity measure computing. The dissimilarity measure function of the input shape and the reference shape are obtained by combining the global matching cost and the local dissimilarity measure. The proposed method has the advantage that there is no need to set any parameter in the recognition process. Experimental results indicate that the hostage string matching approach significantly improves the recognition rates compared to the one-stage string matching method. PMID:18267511

  7. Field programmable gate array time counter with two-stage interpolation

    SciTech Connect

    Szymanowski, Rafal; Kalisz, Jozef

    2005-04-01

    This paper presents a precise time counter with two two-stage interpolators, integrated in a field-programmable gate array device. Interpolation is performed by a single tapped delay line with dual synchronizers in the first stage and a differential tapped delay line in the second stage. The delay-locked loop is used for indirect stabilization of the propagation time of delay elements. The counter has 200 ps resolution over the measurement range of 0-167 ms with the standard measurement uncertainty below 140 ps. A detailed analysis of influence of the flip-flop metastability on the counter accuracy is also presented.

  8. Intensity interactions in cascades of a two-stage Raman fiber laser

    NASA Astrophysics Data System (ADS)

    Babin, S. A.; Churkin, D. V.; Podivilov, E. V.

    2003-10-01

    Effects of intensity interactions (pump power depletion and sequential saturation of cascade generation) have been studied in a two-stage phosphosilicate Raman fiber laser in experiment and modeling. An analytical model of the laser which takes into account power variation along the fiber and spectral broadening of the first Stokes wave has been developed that describes experimental data both qualitatively and quantitatively. Good agreement between calculated and experimental values of the thresholds, differential efficiency for the first and the second Stokes waves and saturation levels for the residual pump and the first Stokes wave powers is demonstrated.

  9. Titanium-copper-nitride coated spacers for two-stage revision of infected total hip endoprostheses

    PubMed Central

    Ellenrieder, Martin; Haenle, Maximilian; Lenz, Robert; Bader, Rainer; Mittelmeier, Wolfram

    2011-01-01

    Within the first two years after total hip arthroplasty implant-associated infection has become the second most common reason for a revision surgery. Two-stage implant exchange is frequently conducted using temporary spacers made of antibiotic-loaded cement in order to prevent a bacterial colonization on the spacer. Avoiding several disadvantages of cement spacers, a conventional hemi-endoprosthesis was equipped with a copper-containing implant coating for inhibition of bacterial biofilms. In the present paper details of this novel treatment concept are presented including a case report. PMID:22242097

  10. Effects of beam velocity spread on two-stage tapered gyro-TWT amplifier

    SciTech Connect

    Nguyen, K.T.; Park, G.S.; Choi, J.J.; Park, S.Y.; Parker, R.K.

    1995-12-31

    Stable operation at a saturated gain of 25 dB over a 20 % instantaneous bandwidth has been observed with a two-stage K{sub a}-band gyro-TWT amplifier at the Naval Research Laboratory. This experiment demonstrated its viability as a source of broadband high-power millimeter waves. However, it has been observed experimentally that sharp gain reductions occur at certain frequencies. To explain this observation, an analytical theory has been developed which describes the effect of electron beam quality on the device`s instantaneous bandwidth. Detailed theory and its implications as well as comparisons with experimental data will be presented and discussed at the conference.

  11. Two-stage earth-to-orbit vehicles with series and parallel burn

    NASA Technical Reports Server (NTRS)

    Martin, J. A.

    1986-01-01

    Recent studies have indicated that a fully reusable earth-to-orbit vehicle system will be needed near the beginning of the next century. One likely concept is a two-stage, vertical takeoff system with liquid rocket propulsion. Such vehicles have been examined with series burn and parallel burn of the engines of each stage. The results indicate that the preferred concept will have parallel burn with crossfeed, the booster will have hydrocarbon engines, the Orbiter will have both hydrocarbon and hydrogen engines, and the staging velocity will be low enough to allow the booster to glide back to the launch site.

  12. [A two-stage kidney rupture following an intrarenal kidney cystic lesion].

    PubMed

    Lungenschmid, D; Furtschegger, A; Kastlunger, W; Jenewein, K

    1991-11-01

    Five days after a blunt trauma with intrarenal rupture of a renal cyst, whereby temporarily a calyceal communication had formed, there was a spontaneous second rupture of the cyst with excessive retroperitoneal haemorrhage. Surgical treatment was necessary and could be accomplished without nephrectomy. Both an arterial bleeding at the bottom of the cyst and a several days' old renal infarction at the edge of the cyst seemed to be relevant for the two-stage rupture. The sonographic, urographic and surgical findings are reported.

  13. Structural requirements and basic design concepts for a two-stage winged launcher system (Saenger)

    NASA Astrophysics Data System (ADS)

    Kuczera, H.; Keller, K.; Kunz, R.

    1988-10-01

    An evaluation is made of materials and structures technologies deemed capable of increasing the mass fraction-to-orbit of the Saenger two-stage launcher system while adequately addressing thermal-control and cryogenic fuel storage insulation problems. Except in its leading edges, nose cone, and airbreathing propulsion system air intakes, Ti alloy-based materials will be the basis of the airframe primary structure. Lightweight metallic thermal-protection measures will be employed. Attention is given to the design of the large lower stage element of Saenger.

  14. Two-stage fixed-bed gasifier with selectable middle gas off-take point

    DOEpatents

    Strickland, Larry D.; Bissett, Larry A.

    1992-01-01

    A two-stage fixed bed coal gasifier wherein an annular region is in registry with a gasification zone underlying a devolatilization zone for extracting a side stream of high temperature substantially tar-free gas from the gasifier. A vertically displaceable skirt means is positioned within the gasifier to define the lower portion of the annular region so that vertical displacement of the skirt means positions the inlet into the annular region in a selected location within or in close proximity to the gasification zone for providing a positive control over the composition of the side stream gas.

  15. Biomass waste gasification - can be the two stage process suitable for tar reduction and power generation?

    PubMed

    Sulc, Jindřich; Stojdl, Jiří; Richter, Miroslav; Popelka, Jan; Svoboda, Karel; Smetana, Jiří; Vacek, Jiří; Skoblja, Siarhei; Buryan, Petr

    2012-04-01

    A pilot scale gasification unit with novel co-current, updraft arrangement in the first stage and counter-current downdraft in the second stage was developed and exploited for studying effects of two stage gasification in comparison with one stage gasification of biomass (wood pellets) on fuel gas composition and attainable gas purity. Significant producer gas parameters (gas composition, heating value, content of tar compounds, content of inorganic gas impurities) were compared for the two stage and the one stage method of the gasification arrangement with only the upward moving bed (co-current updraft). The main novel features of the gasifier conception include grate-less reactor, upward moving bed of biomass particles (e.g. pellets) by means of a screw elevator with changeable rotational speed and gradual expanding diameter of the cylindrical reactor in the part above the upper end of the screw. The gasifier concept and arrangement are considered convenient for thermal power range 100-350 kW(th). The second stage of the gasifier served mainly for tar compounds destruction/reforming by increased temperature (around 950°C) and for gasification reaction of the fuel gas with char. The second stage used additional combustion of the fuel gas by preheated secondary air for attaining higher temperature and faster gasification of the remaining char from the first stage. The measurements of gas composition and tar compound contents confirmed superiority of the two stage gasification system, drastic decrease of aromatic compounds with two and higher number of benzene rings by 1-2 orders. On the other hand the two stage gasification (with overall ER=0.71) led to substantial reduction of gas heating value (LHV=3.15 MJ/Nm(3)), elevation of gas volume and increase of nitrogen content in fuel gas. The increased temperature (>950°C) at the entrance to the char bed caused also substantial decrease of ammonia content in fuel gas. The char with higher content of ash leaving the

  16. Two-stage fluidized-bed/cyclonic agglomerating incinerator. Technology spotlight report

    SciTech Connect

    1995-08-01

    The two-stage fluidized-bed/cyclonic agglomerating incinerator combines and improves upon the fluidized-bed, agglomeration/ incineration-technology and the cyclonic-combustion technology developed at Institute of Gas Technolgy (IGT) over many years. The result is a unique and extremely flexible incinerator for solid, liquid, and gaseous wastes. The system can operate over a wide range of conditions and has a destruction and removal efficiency (DRE) greater than 99.99%. Solid inorganic contaminants are contained within aglassy matrix, rendering them benign and suitable for disposal in an ordinary landfill.

  17. A Two-Stage Bunch Compressor Option for the US Cold LC

    SciTech Connect

    Raubenheimer, T

    2004-07-21

    To increase the luminosity or improve the stability of the US Cold LC design, it would be advantageous to decrease the bunch length below the specified 300 mu m. It is unlikely that further compression would be possible with the single stage compressor proposed in TESLA design and thus in this note we scale the two-stage NLC bunch compressor design to the US Cold LC design. The primary difficulties with this scaling are related to the much larger (factor of 3.6 times larger) longitudinal emittance in the US Cold LC design.

  18. Two-stage method to suppress speckle noise in digital holography

    NASA Astrophysics Data System (ADS)

    Leng, Junmin; Zhou, Jinhe; Lang, Xiaoping; Li, Xiaoying

    2015-10-01

    The two-stage method is proposed to suppress speckle noise in the digital hologram. Three kinds of optical denoising ways are analyzed and compared at first. The optimal one is used to reduce speckle preliminarily. At the same time, the statistical property of the speckle is changed by the optical way. Then the optimized NLM algorithm is adopted to further suppress speckle noise. The experimental system is set up, and the performance indices are calculated. The results are compared with other algorithms. It is demonstrated that the presented method can effectively suppress speckle noise in the digital hologram and the processed image is very vivid.

  19. Two-stage continuous fermentation of Saccharomycopsis fibuligeria and Candida utilis.

    PubMed

    Admassu, W; Korus, R A; Heimsch, R C

    1983-11-01

    Biomass production and carbohydrate reduction were determined for a two-stage continuous fermentation process with a simulated potato processing waste feed. The amylolytic yeast Saccharomycopsis fibuligera was grown in the first stage and a mixed culture of S. fibuligera and Candida utilis was maintained in the second stage. All conditions for the first and second stages were fixed except the flow of medium to the second stage was varied. Maximum biomass production occurred at a second stage dilution rate, D(2), of 0.27 h (-1). Carbohydrate reduction was inversely proportional to D(2), between 0.10 and 0.35 h (-1).

  20. Simulation of the Two Stages Stretch-Blow Molding Process: Infrared Heating and Blowing Modeling

    SciTech Connect

    Bordival, M.; Schmidt, F. M.; Le Maoult, Y.; Velay, V.

    2007-05-17

    In the Stretch-Blow Molding (SBM) process, the temperature distribution of the reheated perform affects drastically the blowing kinematic, the bottle thickness distribution, as well as the orientation induced by stretching. Consequently, mechanical and optical properties of the final bottle are closely related to heating conditions. In order to predict the 3D temperature distribution of a rotating preform, numerical software using control-volume method has been developed. Since PET behaves like a semi-transparent medium, the radiative flux absorption was computed using Beer Lambert law. In a second step, 2D axi-symmetric simulations of the SBM have been developed using the finite element package ABAQUS registered . Temperature profiles through the preform wall thickness and along its length were computed and applied as initial condition. Air pressure inside the preform was not considered as an input variable, but was automatically computed using a thermodynamic model. The heat transfer coefficient applied between the mold and the polymer was also measured. Finally, the G'sell law was used for modeling PET behavior. For both heating and blowing stage simulations, a good agreement has been observed with experimental measurements. This work is part of the European project ''APT{sub P}ACK'' (Advanced knowledge of Polymer deformation for Tomorrow's PACKaging)

  1. Advanced Models of LWR Pressure Vessel Embrittlement for Low Flux-HighFluence Conditions

    SciTech Connect

    Odette, G. Robert; Yamamoto, Takuya

    2013-06-17

    Neutron embrittlement of reactor pressure vessels (RPVs) is an unresolved issue for light water reactor life extension, especially since transition temperature shifts (TTS) must be predicted for high 80-year fluence levels up to approximately 1,020 n/cm{sup 2}, far beyond the current surveillance database. Unfortunately, TTS may accelerate at high fluence, and may be further amplified by the formation of late blooming phases that result in severe embrittlement even in low-copper (Cu) steels. Embrittlement by this mechanism is a potentially significant degradation phenomenon that is not predicted by current regulatory models. This project will focus on accurately predicting transition temperature shifts at high fluence using advanced physically based, empirically validated and calibrated models. A major challenge is to develop models that can adjust test reactor data to account for flux effects. Since transition temperature shifts depend on synergistic combinations of many variables, flux-effects cannot be treated in isolation. The best current models systematically and significantly under-predict transition temperature at high fluence, although predominantly for irradiations at much higher flux than actual RPV service. This project will integrate surveillance, test reactor and mechanism data with advanced models to address a number of outstanding RPV embrittlement issues. The effort will include developing new databases and preliminary models of flux effects for irradiation conditions ranging from very low (e.g., boiling water reactor) to high (e.g., accelerated test reactor). The team will also develop a database and physical models to help predict the conditions for the formation of Mn-Ni-Si late blooming phases and to guide future efforts to fully resolve this issue. Researchers will carry out other tasks on a best-effort basis, including prediction of transition temperature shift attenuation through the vessel wall, remediation of embrittlement by annealing

  2. A Two-Stage Method to Determine Optimal Product Sampling considering Dynamic Potential Market

    PubMed Central

    Hu, Zhineng; Lu, Wei; Han, Bing

    2015-01-01

    This paper develops an optimization model for the diffusion effects of free samples under dynamic changes in potential market based on the characteristics of independent product and presents a two-stage method to figure out the sampling level. The impact analysis of the key factors on the sampling level shows that the increase of the external coefficient or internal coefficient has a negative influence on the sampling level. And the changing rate of the potential market has no significant influence on the sampling level whereas the repeat purchase has a positive one. Using logistic analysis and regression analysis, the global sensitivity analysis gives a whole analysis of the interaction of all parameters, which provides a two-stage method to estimate the impact of the relevant parameters in the case of inaccuracy of the parameters and to be able to construct a 95% confidence interval for the predicted sampling level. Finally, the paper provides the operational steps to improve the accuracy of the parameter estimation and an innovational way to estimate the sampling level. PMID:25821847

  3. Two-stage fuzzy-stochastic robust programming: a hybrid model for regional air quality management.

    PubMed

    Li, Yongping; Huang, Guo H; Veawab, Amornvadee; Nie, Xianghui; Liu, Lei

    2006-08-01

    In this study, a hybrid two-stage fuzzy-stochastic robust programming (TFSRP) model is developed and applied to the planning of an air-quality management system. As an extension of existing fuzzy-robust programming and two-stage stochastic programming methods, the TFSRP can explicitly address complexities and uncertainties of the study system without unrealistic simplifications. Uncertain parameters can be expressed as probability density and/or fuzzy membership functions, such that robustness of the optimization efforts can be enhanced. Moreover, economic penalties as corrective measures against any infeasibilities arising from the uncertainties are taken into account. This method can, thus, provide a linkage to predefined policies determined by authorities that have to be respected when a modeling effort is undertaken. In its solution algorithm, the fuzzy decision space can be delimited through specification of the uncertainties using dimensional enlargement of the original fuzzy constraints. The developed model is applied to a case study of regional air quality management. The results indicate that reasonable solutions have been obtained. The solutions can be used for further generating pollution-mitigation alternatives with minimized system costs and for providing a more solid support for sound environmental decisions. PMID:16933639

  4. Development of a Two-Stage Microalgae Dewatering Process - A Life Cycle Assessment Approach.

    PubMed

    Soomro, Rizwan R; Ndikubwimana, Theoneste; Zeng, Xianhai; Lu, Yinghua; Lin, Lu; Danquah, Michael K

    2016-01-01

    Even though microalgal biomass is leading the third generation biofuel research, significant effort is required to establish an economically viable commercial-scale microalgal biofuel production system. Whilst a significant amount of work has been reported on large-scale cultivation of microalgae using photo-bioreactors and pond systems, research focus on establishing high performance downstream dewatering operations for large-scale processing under optimal economy is limited. The enormous amount of energy and associated cost required for dewatering large-volume microalgal cultures has been the primary hindrance to the development of the needed biomass quantity for industrial-scale microalgal biofuels production. The extremely dilute nature of large-volume microalgal suspension and the small size of microalgae cells in suspension create a significant processing cost during dewatering and this has raised major concerns towards the economic success of commercial-scale microalgal biofuel production as an alternative to conventional petroleum fuels. This article reports an effective framework to assess the performance of different dewatering technologies as the basis to establish an effective two-stage dewatering system. Bioflocculation coupled with tangential flow filtration (TFF) emerged a promising technique with total energy input of 0.041 kWh, 0.05 kg CO2 emissions and a cost of $ 0.0043 for producing 1 kg of microalgae biomass. A streamlined process for operational analysis of two-stage microalgae dewatering technique, encompassing energy input, carbon dioxide emission, and process cost, is presented.

  5. A high-sensitivity biaxial resonant accelerometer with two-stage microleverage mechanisms

    NASA Astrophysics Data System (ADS)

    Ding, Hong; Zhao, Jiuxuan; Ju, Bing-Feng; Xie, Jin

    2016-01-01

    This paper presents a design and experimental evaluation of a micro-electro-mechanical system biaxial resonant accelerometer with two-stage microleverage mechanisms. The device incorporates two pairs of double-ended tuning fork resonators coupled to a single proof mass. The two-stage microleverage mechanisms possess a higher amplification factor than single-stage microleverage mechanisms, so that the proposed accelerometer has a high level of sensitivity. In addition, a low level of cross-axis sensitivity is realized because of the decoupling beams. The accelerometer is theoretically analyzed and then simulated in the system level by the finite element method. The device is fabricated in a silicon-on-insulator wafer. The experimental results demonstrate that the average differential sensitivity of the resonant accelerometer is 275 Hz g-1 at a resonant frequency of 290 kHz under a polarization voltage of 5 V. The measured cross-axis sensitivity is lower than 3.4%.

  6. An operational rate control scheme for H.264 with two-stage encoding

    NASA Astrophysics Data System (ADS)

    Kwon, Do-Kyoung; Shen, Mei-Yin; Kuo, C.-C. Jay

    2005-08-01

    An operational rate control (RC) scheme based on two-stage encoding is studied in this research, where frame-layer rate control with a constant bit rate to achieve constant video quality is examined. In the first encoding stage, the R-D optimized mode decision and its associated motion estimation (RDO) as well as DCT/Q, IQ/IDCT and entropy coding are performed for all macroblocks (MBs) for a target frame using an initial quantization parameter (QP), which is the QP of its previous frame. In the second encoding stage, the residual signal from the first stage is encoded using several QP values around the initial QP. Given the target bits and distortion for the current frame, the residual signal is finally encoded using the QP determined by comparing target bits and distortion with actual bits and distortion. To reduce the additional coding complexity of the two-stage encoding, upper and lower bounds around target bits and distortion are employed to reduce the number of encoding required in the second stage. Experimental results are given to show the superior performance of two proposed rate control algorithms, where one targets at the constant bit rate while the other at constant quality.

  7. A two-stage enzymatic ethanol-based biodiesel production in a packed bed reactor.

    PubMed

    Xu, Yuan; Nordblad, Mathias; Woodley, John M

    2012-12-31

    A two-stage enzymatic process for producing fatty acid ethyl ester (FAEE) in a packed bed reactor is reported. The process uses an experimental immobilized lipase (NS 88001) and Novozym 435 to catalyze transesterification (first stage) and esterification (second stage), respectively. Both stages were conducted in a simulated series of reactors by repeatedly passing the reaction mixture through a single reactor, with separation of the by-product glycerol and water between passes in the first and second stages, respectively. The second stage brought the major components of biodiesel to 'in-spec' levels according to the European biodiesel specifications for methanol-based biodiesel. The highest overall productivity achieved in the first stage was 2.52 kg FAEE(kg catalyst)⁻¹ h⁻¹ at a superficial velocity of 7.6 cm min⁻¹, close to the efficiency of a stirred tank reactor under similar conditions. The overall productivity of the proposed two-stage process was 1.56 kg FAEE(kg catalyst)⁻¹ h⁻¹. Based on this process model, the challenges of scale-up have been addressed and potential continuous process options have been proposed.

  8. Reductive decolourisation of sulphonated mono and diazo dyes in one- and two-stage anaerobic systems.

    PubMed

    da Silva, Marcos Erick Rodrigues; Firmino, Paulo Igor Milen; dos Santos, André Bezerra

    2013-05-01

    This work assessed the application of one- and two-stage mesophilic anaerobic systems to colour removal of sulphonated mono and diazo dyes with ethanol as electron donor. The dyes Congo Red (CR), Reactive Black 5 (RB5) and Reactive Red 2 (RR2) were selected as model compounds and tested separately in seven different periods. The one-stage system (R(1)) consisted of a single up-flow anaerobic sludge blanket (UASB) reactor, whereas the two-stage system (R(2)) consisted of an acidogenic UASB reactor (R(A)), a settler and a methanogenic UASB reactor (R(M)). For CR and RB5, no remarkable difference was observed between the colour removal performance of both anaerobic systems R(1) and R(2). The experiments with RR2 revealed that R(2) was more efficient on colour removal than R(1), showing efficiencies almost 2-fold (period VI) and 2.5-fold (period VII) higher than those found by R(1). Additionally, R(2) showed a higher stability, giving a good prospect for application to textile wastewaters. Finally, the acidogenic reactor (R(A)) had an important role in the overall decolourisation achieved by R(2) during the experiments with CR and RB5 (>78 %), whereas for RR2, a more recalcitrant dye, R(A) was responsible for up to 38 % of the total colour removal. PMID:23456307

  9. Methods of Designing Two-stage Winner Trials with Survival Outcomes

    PubMed Central

    Fang, Fang; Lin, Yong; Shih, Weichung J.; Li, Yulin; Yang, Jay; Zhang, Xiaosha

    2014-01-01

    In drug development, especially for oncology studies, a recent proposal is to combine a costly phase II dose selection study with a subsequent phase III study into a single trial that compares the selected (winning) dose from the first stage with the control group. This design may also be used in phase III trials, in which the winning active treatment regimen, selected at the first stage, is compared with the control group at the second stage. This design is known as a two-stage winner design, as proposed by Shun et al [1] for continuous outcomes. Time-to-event data are often analyzed in oncology trials. In order to derive the critical value and power of this design, per Shun et al [1], it is essential to calculate the asymptotic covariance and correlation of the log-rank statistics for survival outcomes between the two stages. In this paper, we derive the asymptotic covariance and correlation, and provide additional approximate design parameters. Examples are given to illustrate the method, and simulations are performed to evaluate the veracity of these approximate design parameters. PMID:24347247

  10. Optimal adaptive two-stage designs for early phase II clinical trials.

    PubMed

    Shan, Guogen; Wilding, Gregory E; Hutson, Alan D; Gerstenberger, Shawn

    2016-04-15

    Simon's optimal two-stage design has been widely used in early phase clinical trials for Oncology and AIDS studies with binary endpoints. With this approach, the second-stage sample size is fixed when the trial passes the first stage with sufficient activity. Adaptive designs, such as those due to Banerjee and Tsiatis (2006) and Englert and Kieser (2013), are flexible in the sense that the second-stage sample size depends on the response from the first stage, and these designs are often seen to reduce the expected sample size under the null hypothesis as compared with Simon's approach. An unappealing trait of the existing designs is that they are not associated with a second-stage sample size, which is a non-increasing function of the first-stage response rate. In this paper, an efficient intelligent process, the branch-and-bound algorithm, is used in extensively searching for the optimal adaptive design with the smallest expected sample size under the null, while the type I and II error rates are maintained and the aforementioned monotonicity characteristic is respected. The proposed optimal design is observed to have smaller expected sample sizes compared to Simon's optimal design, and the maximum total sample size of the proposed adaptive design is very close to that from Simon's method. The proposed optimal adaptive two-stage design is recommended for use in practice to improve the flexibility and efficiency of early phase therapeutic development. PMID:26526165

  11. Performance of two-stage vegetable waste anaerobic digestion depending on varying recirculation rates.

    PubMed

    Zuo, Zhuang; Wu, Shubiao; Zhang, Wanqin; Dong, Renjie

    2014-06-01

    Vegetable waste, which characterized by high moisture content, was evaluated as a substrate for biogas production. The effects of recirculation rate (RR) on the performance of two-stage anaerobic digestion were investigated. The system was operated at an organic loading rate of 1.7 g VS/L/d with varying RRs (0, 0.6, 1, and 1.4). Results demonstrated that volumetric biogas production rates in acidogenic reactor increased from approximately 0.2 7 L/L/d to 0.97 L/L/d, when pH is increased from approximately 5.1 to 6.7. These indicate that recirculation of alkaline effluent from the methanogenic reactor helps create a favorable condition for biogas production in the acidogenic reactor. The decrease in chemical oxygen demand (COD) concentrations from approximately 21,000 mg/L to 6800 mg/L was also observed in the acidogenic reactor. This condition may be attributed to dilution under recirculation. The dynamics between hydrolysis and methanogenesis under recirculation indicated that mass transfer capacity between two-stage reactors improved. PMID:24759642

  12. A two-stage method to determine optimal product sampling considering dynamic potential market.

    PubMed

    Hu, Zhineng; Lu, Wei; Han, Bing

    2015-01-01

    This paper develops an optimization model for the diffusion effects of free samples under dynamic changes in potential market based on the characteristics of independent product and presents a two-stage method to figure out the sampling level. The impact analysis of the key factors on the sampling level shows that the increase of the external coefficient or internal coefficient has a negative influence on the sampling level. And the changing rate of the potential market has no significant influence on the sampling level whereas the repeat purchase has a positive one. Using logistic analysis and regression analysis, the global sensitivity analysis gives a whole analysis of the interaction of all parameters, which provides a two-stage method to estimate the impact of the relevant parameters in the case of inaccuracy of the parameters and to be able to construct a 95% confidence interval for the predicted sampling level. Finally, the paper provides the operational steps to improve the accuracy of the parameter estimation and an innovational way to estimate the sampling level.

  13. Two stage, low temperature, catalyzed fluidized bed incineration with in situ neutralization for radioactive mixed wastes

    SciTech Connect

    Wade, J.F.; Williams, P.M.

    1995-05-17

    A two stage, low temperature, catalyzed fluidized bed incineration process is proving successful at incinerating hazardous wastes containing nuclear material. The process operates at 550{degrees}C and 650{degrees}C in its two stages. Acid gas neutralization takes place in situ using sodium carbonate as a sorbent in the first stage bed. The feed material to the incinerator is hazardous waste-as defined by the Resource Conservation and Recovery Act-mixed with radioactive materials. The radioactive materials are plutonium, uranium, and americium that are byproducts of nuclear weapons production. Despite its low temperature operation, this system successfully destroyed poly-chlorinated biphenyls at a 99.99992% destruction and removal efficiency. Radionuclides and volatile heavy metals leave the fluidized beds and enter the air pollution control system in minimal amounts. Recently collected modeling and experimental data show the process minimizes dioxin and furan production. The report also discusses air pollution, ash solidification, and other data collected from pilot- and demonstration-scale testing. The testing took place at Rocky Flats Environmental Technology Site, a US Department of Energy facility, in the 1970s, 1980s, and 1990s.

  14. Estimating accuracy of land-cover composition from two-stage cluster sampling

    USGS Publications Warehouse

    Stehman, S.V.; Wickham, J.D.; Fattorini, L.; Wade, T.D.; Baffetta, F.; Smith, J.H.

    2009-01-01

    Land-cover maps are often used to compute land-cover composition (i.e., the proportion or percent of area covered by each class), for each unit in a spatial partition of the region mapped. We derive design-based estimators of mean deviation (MD), mean absolute deviation (MAD), root mean square error (RMSE), and correlation (CORR) to quantify accuracy of land-cover composition for a general two-stage cluster sampling design, and for the special case of simple random sampling without replacement (SRSWOR) at each stage. The bias of the estimators for the two-stage SRSWOR design is evaluated via a simulation study. The estimators of RMSE and CORR have small bias except when sample size is small and the land-cover class is rare. The estimator of MAD is biased for both rare and common land-cover classes except when sample size is large. A general recommendation is that rare land-cover classes require large sample sizes to ensure that the accuracy estimators have small bias. ?? 2009 Elsevier Inc.

  15. A two-stage sequential linear programming approach to IMRT dose optimization

    PubMed Central

    Zhang, Hao H; Meyer, Robert R; Wu, Jianzhou; Naqvi, Shahid A; Shi, Leyuan; D’Souza, Warren D

    2010-01-01

    The conventional IMRT planning process involves two stages in which the first stage consists of fast but approximate idealized pencil beam dose calculations and dose optimization and the second stage consists of discretization of the intensity maps followed by intensity map segmentation and a more accurate final dose calculation corresponding to physical beam apertures. Consequently, there can be differences between the presumed dose distribution corresponding to pencil beam calculations and optimization and a more accurately computed dose distribution corresponding to beam segments that takes into account collimator-specific effects. IMRT optimization is computationally expensive and has therefore led to the use of heuristic (e.g., simulated annealing and genetic algorithms) approaches that do not encompass a global view of the solution space. We modify the traditional two-stage IMRT optimization process by augmenting the second stage via an accurate Monte-Carlo based kernel-superposition dose calculations corresponding to beam apertures combined with an exact mathematical programming based sequential optimization approach that uses linear programming (SLP). Our approach was tested on three challenging clinical test cases with multileaf collimator constraints corresponding to two vendors. We compared our approach to the conventional IMRT planning approach, a direct-aperture approach and a segment weight optimization approach. Our results in all three cases indicate that the SLP approach outperformed the other approaches, achieving superior critical structure sparing. Convergence of our approach is also demonstrated. Finally, our approach has also been integrated with a commercial treatment planning system and may be utilized clinically. PMID:20071764

  16. Development of a Two-Stage Microalgae Dewatering Process - A Life Cycle Assessment Approach.

    PubMed

    Soomro, Rizwan R; Ndikubwimana, Theoneste; Zeng, Xianhai; Lu, Yinghua; Lin, Lu; Danquah, Michael K

    2016-01-01

    Even though microalgal biomass is leading the third generation biofuel research, significant effort is required to establish an economically viable commercial-scale microalgal biofuel production system. Whilst a significant amount of work has been reported on large-scale cultivation of microalgae using photo-bioreactors and pond systems, research focus on establishing high performance downstream dewatering operations for large-scale processing under optimal economy is limited. The enormous amount of energy and associated cost required for dewatering large-volume microalgal cultures has been the primary hindrance to the development of the needed biomass quantity for industrial-scale microalgal biofuels production. The extremely dilute nature of large-volume microalgal suspension and the small size of microalgae cells in suspension create a significant processing cost during dewatering and this has raised major concerns towards the economic success of commercial-scale microalgal biofuel production as an alternative to conventional petroleum fuels. This article reports an effective framework to assess the performance of different dewatering technologies as the basis to establish an effective two-stage dewatering system. Bioflocculation coupled with tangential flow filtration (TFF) emerged a promising technique with total energy input of 0.041 kWh, 0.05 kg CO2 emissions and a cost of $ 0.0043 for producing 1 kg of microalgae biomass. A streamlined process for operational analysis of two-stage microalgae dewatering technique, encompassing energy input, carbon dioxide emission, and process cost, is presented. PMID:26904075

  17. Decreasing Impact Tilt on a High Performance Two-Stage Gas Gun

    NASA Astrophysics Data System (ADS)

    Byers, M. E.; Rigg, P. A.; Esparza, J. S.

    2007-06-01

    There are four high-performance two-stage light gas guns in operation in the DOE complex. All four guns are similar in performance and diagnostics capabilities. Projectile velocity on these guns has typically been measured using a combination of magnetic coils and two frames of flash radiography. This requires that the projectile be in 'free flight' for a long distance (18 to 25 inches typical) in order to capture the projectile in flight. This leads to typical projectile tilt at impact in excess of 10 mrad. Recently, we have replaced the coil/x-ray system on the LANL high performance two-stage gun with Photonic Doppler Velocimetry (PDV) to obtain high accuracy (0.1%) projectile velocity measurements. This allows us to move the target very close to the end of the barrel to potentially decrease the impact tilt significantly. We will present the results of this study and compare them to the performance of the gun when the free flight section was present.

  18. A two-stage inexact joint-probabilistic programming method for air quality management under uncertainty.

    PubMed

    Lv, Y; Huang, G H; Li, Y P; Yang, Z F; Sun, W

    2011-03-01

    A two-stage inexact joint-probabilistic programming (TIJP) method is developed for planning a regional air quality management system with multiple pollutants and multiple sources. The TIJP method incorporates the techniques of two-stage stochastic programming, joint-probabilistic constraint programming and interval mathematical programming, where uncertainties expressed as probability distributions and interval values can be addressed. Moreover, it can not only examine the risk of violating joint-probability constraints, but also account for economic penalties as corrective measures against any infeasibility. The developed TIJP method is applied to a case study of a regional air pollution control problem, where the air quality index (AQI) is introduced for evaluation of the integrated air quality management system associated with multiple pollutants. The joint-probability exists in the environmental constraints for AQI, such that individual probabilistic constraints for each pollutant can be efficiently incorporated within the TIJP model. The results indicate that useful solutions for air quality management practices have been generated; they can help decision makers to identify desired pollution abatement strategies with minimized system cost and maximized environmental efficiency. PMID:21067860

  19. Two-stage planning for sustainable water-quality management under uncertainty.

    PubMed

    Li, Y P; Huang, G H

    2009-06-01

    In water-quality management problems, uncertainties may exist in a number of impact factors and pollution-related processes (e.g., the volume and strength of industrial wastewater and their variations can be presented as random events through identifying a statistical distribution for each source); moreover, nonlinear relationships may exist among many system components (e.g., cost parameters may be functions of wastewater-discharge levels). In this study, an inexact two-stage stochastic quadratic programming (ITQP) method is developed for water-quality management under uncertainty. It is a hybrid of inexact quadratic programming (IQP) and two-stage stochastic programming (TSP) methods. The developed ITQP can handle not only uncertainties expressed as probability distributions and interval values but also nonlinearities in the objective function. It can be used for analyzing various scenarios that are associated with different levels of economic penalties or opportunity losses caused by improper policies. The ITQP is applied to a case of water-quality management to deal with uncertainties presented in terms of probabilities and intervals and to reflect dynamic interactions between pollutant loading and water quality. Interactive and derivative algorithms are employed for solving the ITQP model. The solutions are presented as combinations of deterministic, interval and distributional information, and can thus facilitate communications for different forms of uncertainties. They are helpful for managers in not only making decisions regarding wastewater discharge but also gaining insight into the tradeoff between the system benefit and the environmental requirement.

  20. Occurrence of two-stage hardening in C-Mn steel wire rods containing pearlitic microstructure

    NASA Astrophysics Data System (ADS)

    Singh, Balbir; Sahoo, Gadadhar; Saxena, Atul

    2016-09-01

    The 8 and 10 mm diameter wire rods intended for use as concrete reinforcement were produced/ hot rolled from C-Mn steel chemistry containing various elements within the range of C:0.55-0.65, Mn:0.85-1.50, Si:0.05-0.09, S:0.04 max, P:0.04 max and N:0.006 max wt%. Depending upon the C and Mn contents the product attained pearlitic microstructure in the range of 85-93% with balance amount of polygonal ferrite transformed at prior austenite grain boundaries. The pearlitic microstructure in the wire rods helped in achieving yield strength, tensile strength, total elongation and reduction in area values within the range of 422-515 MPa, 790-950 MPa, 22-15% and 45-35%, respectively. On analyzing the tensile results it was revealed that the material experienced hardening in two stages separable by a knee strain value of about 0.05. The occurrence of two stage hardening thus in the steel with hardening coefficients of 0.26 and 0.09 could be demonstrated with the help of derived relationships existed between flow stress and the strain.

  1. XPG Gene Polymorphisms Contribute to Colorectal Cancer Susceptibility: A Two-Stage Case-Control Study

    PubMed Central

    Hua, Rui-Xi; Zhuo, Zhen-Jian; Zhu, Jinhong; Zhang, Shao-Dan; Xue, Wen-Qiong; Zhang, Jiang-Bo; Xu, Hong-Mei; Li, Xi-Zhao; Zhang, Pei-Fen; He, Jing; Jia, Wei-Hua

    2016-01-01

    Previous studies have reported that xeroderma pigmentosum group G (XPG) gene polymorphisms may modulate colorectal cancer (CRC) susceptibility. In this study, we performed a two-stage case-control study to comprehensively investigate the associations of five polymorphisms in the XPG gene with CRC risk in 1,901 cases and 1,976 controls from Southern China, including rs2094258 C>T, rs751402 C>T, rs2296147 T>C, rs1047768 T>C and rs873601 G>A. After combining data from two stages, we found that three of the studied polymorphisms (rs2094258 C>T, rs751402 C>T, and rs873601 G>A) were significantly associated with CRC susceptibility. After adjustment for age and gender, multivariate logistic regression analysis indicated that carriers of the rs2094258 T alleles had an increased CRC risk [CT vs. CC: adjusted odds ratio (OR)=1.17, 95% confidence interval (CI)=1.01-1.36; TT vs. CC: adjusted OR=1.49, 95% CI=1.18-1.89; TT vs. CT/CC: adjusted OR=1.38, 95% CI=1.10-1.72]. Likely, rs873601 A allele also conferred increased CRC susceptibility. In contrast, a protective association was identified between rs751402 C>T polymorphism and the risk of CRC. In summary, our results indicated that these three polymorphisms were found to associate with CRC susceptibility in a Southern Chinese population.

  2. Options for thrust augmentation for the Beta 2 two-stage-to-orbit launch vehicle

    NASA Technical Reports Server (NTRS)

    Jules, Kenol

    1993-01-01

    A study to improve the performance of the NASA two-stage-to-orbit vehicle was undertaken. The NASA concept, a horizontal takeoff and landing, fully reusable, two-stage to orbit vehicle, will be capable of launching and returning a 10,000 pound payload to a 100 nmi polar orbit. The vehicle, Beta 2, is a derivative of the USAF/Boeing Beta vehicle which was designed to deliver a 50,000 pound payload to a similar orbit. Beta 2 stages at Mach 6.5 and about 100,000 feet altitude. The propulsion system for the booster is an over/under turbine engine/ramjet configuration. In this paper a study was performed for one of the candidate engines, the variable cycle engine, to assess its potential to meet the required performance needs of the Beta 2 vehicle. Several options for thrust augmentation were studied in order to improve the performance of the engine where there was a critical need. The methodology, constraints, propulsion performance, and mission study results are presented.

  3. Two-stage effects of awareness cascade on epidemic spreading in multiplex networks

    NASA Astrophysics Data System (ADS)

    Guo, Quantong; Jiang, Xin; Lei, Yanjun; Li, Meng; Ma, Yifang; Zheng, Zhiming

    2015-01-01

    Human awareness plays an important role in the spread of infectious diseases and the control of propagation patterns. The dynamic process with human awareness is called awareness cascade, during which individuals exhibit herd-like behavior because they are making decisions based on the actions of other individuals [Borge-Holthoefer et al., J. Complex Networks 1, 3 (2013), 10.1093/comnet/cnt006]. In this paper, to investigate the epidemic spreading with awareness cascade, we propose a local awareness controlled contagion spreading model on multiplex networks. By theoretical analysis using a microscopic Markov chain approach and numerical simulations, we find the emergence of an abrupt transition of epidemic threshold βc with the local awareness ratio α approximating 0.5 , which induces two-stage effects on epidemic threshold and the final epidemic size. These findings indicate that the increase of α can accelerate the outbreak of epidemics. Furthermore, a simple 1D lattice model is investigated to illustrate the two-stage-like sharp transition at αc≈0.5 . The results can give us a better understanding of why some epidemics cannot break out in reality and also provide a potential access to suppressing and controlling the awareness cascading systems.

  4. A two-stage broadcast message propagation model in social networks

    NASA Astrophysics Data System (ADS)

    Wang, Dan; Cheng, Shun-Jun

    2016-11-01

    Message propagation in social networks is becoming a popular topic in complex networks. One of the message types in social networks is called broadcast message. It refers to a type of message which has a unique and unknown destination for the publisher, such as 'lost and found'. Its propagation always has two stages. Due to this feature, rumor propagation model and epidemic propagation model have difficulty in describing this message's propagation accurately. In this paper, an improved two-stage susceptible-infected-removed model is proposed. We come up with the concept of the first forwarding probability and the second forwarding probability. Another part of our work is figuring out the influence to the successful message transmission chance in each level resulting from multiple reasons, including the topology of the network, the receiving probability, the first stage forwarding probability, the second stage forwarding probability as well as the length of the shortest path between the publisher and the relevant destination. The proposed model has been simulated on real networks and the results proved the model's effectiveness.

  5. Two-stage fuzzy-stochastic robust programming: a hybrid model for regional air quality management

    SciTech Connect

    Yongping Li; Guo H. Huang; Amornvadee Veawab; Xianghui Nie; Lei Liu

    2006-08-15

    In this study, a hybrid two-stage fuzzy-stochastic robust programming (TFSRP) model is developed and applied to the planning of an air-quality management system. As an extension of existing fuzzy-robust programming and two stage stochastic programming methods, the TFSRP can explicitly address complexities and uncertainties of the study system without unrealistic simplifications. Uncertain parameters can be expressed as probability density and/or fuzzy membership functions, such that robustness of the optimization efforts can be enhanced. Moreover, economic penalties as corrective measures against any infeasibilities arising from the uncertainties are taken into account. This method can, thus, provide a linkage to predefined policies determined by authorities that have to be respected when a modeling effort is undertaken. In its solution algorithm, the fuzzy decision space can be delimited through specification of the uncertainties using dimensional enlargement of the original fuzzy constraints. The developed model is applied to a case study of regional air quality management at two coal-fired power plants considered as major sulfur dioxide emission sources. The results indicate that reasonable solutions have been obtained. The solutions can be used for further generating pollution-mitigation alternatives with minimized system costs and for providing a more solid support for sound environmental decisions. 61 refs., 7 figs., 6 tabs.

  6. Interactive two-stage stochastic fuzzy programming for water resources management.

    PubMed

    Wang, S; Huang, G H

    2011-08-01

    In this study, an interactive two-stage stochastic fuzzy programming (ITSFP) approach has been developed through incorporating an interactive fuzzy resolution (IFR) method within an inexact two-stage stochastic programming (ITSP) framework. ITSFP can not only tackle dual uncertainties presented as fuzzy boundary intervals that exist in the objective function and the left- and right-hand sides of constraints, but also permit in-depth analyses of various policy scenarios that are associated with different levels of economic penalties when the promised policy targets are violated. A management problem in terms of water resources allocation has been studied to illustrate applicability of the proposed approach. The results indicate that a set of solutions under different feasibility degrees has been generated for planning the water resources allocation. They can help the decision makers (DMs) to conduct in-depth analyses of tradeoffs between economic efficiency and constraint-violation risk, as well as enable them to identify, in an interactive way, a desired compromise between satisfaction degree of the goal and feasibility of the constraints (i.e., risk of constraint violation).

  7. Two-stage fuzzy-stochastic robust programming: a hybrid model for regional air quality management.

    PubMed

    Li, Yongping; Huang, Guo H; Veawab, Amornvadee; Nie, Xianghui; Liu, Lei

    2006-08-01

    In this study, a hybrid two-stage fuzzy-stochastic robust programming (TFSRP) model is developed and applied to the planning of an air-quality management system. As an extension of existing fuzzy-robust programming and two-stage stochastic programming methods, the TFSRP can explicitly address complexities and uncertainties of the study system without unrealistic simplifications. Uncertain parameters can be expressed as probability density and/or fuzzy membership functions, such that robustness of the optimization efforts can be enhanced. Moreover, economic penalties as corrective measures against any infeasibilities arising from the uncertainties are taken into account. This method can, thus, provide a linkage to predefined policies determined by authorities that have to be respected when a modeling effort is undertaken. In its solution algorithm, the fuzzy decision space can be delimited through specification of the uncertainties using dimensional enlargement of the original fuzzy constraints. The developed model is applied to a case study of regional air quality management. The results indicate that reasonable solutions have been obtained. The solutions can be used for further generating pollution-mitigation alternatives with minimized system costs and for providing a more solid support for sound environmental decisions.

  8. Development of a Two-Stage Microalgae Dewatering Process – A Life Cycle Assessment Approach

    PubMed Central

    Soomro, Rizwan R.; Zeng, Xianhai; Lu, Yinghua; Lin, Lu; Danquah, Michael K.

    2016-01-01

    Even though microalgal biomass is leading the third generation biofuel research, significant effort is required to establish an economically viable commercial-scale microalgal biofuel production system. Whilst a significant amount of work has been reported on large-scale cultivation of microalgae using photo-bioreactors and pond systems, research focus on establishing high performance downstream dewatering operations for large-scale processing under optimal economy is limited. The enormous amount of energy and associated cost required for dewatering large-volume microalgal cultures has been the primary hindrance to the development of the needed biomass quantity for industrial-scale microalgal biofuels production. The extremely dilute nature of large-volume microalgal suspension and the small size of microalgae cells in suspension create a significant processing cost during dewatering and this has raised major concerns towards the economic success of commercial-scale microalgal biofuel production as an alternative to conventional petroleum fuels. This article reports an effective framework to assess the performance of different dewatering technologies as the basis to establish an effective two-stage dewatering system. Bioflocculation coupled with tangential flow filtration (TFF) emerged a promising technique with total energy input of 0.041 kWh, 0.05 kg CO2 emissions and a cost of $ 0.0043 for producing 1 kg of microalgae biomass. A streamlined process for operational analysis of two-stage microalgae dewatering technique, encompassing energy input, carbon dioxide emission, and process cost, is presented. PMID:26904075

  9. A new strategy to enhance gellan production by two-stage culture in Sphingomonas paucimobilis.

    PubMed

    Zhu, Guilan; Sheng, Long; Tong, Qunyi

    2013-10-15

    The effects of different initial sucrose concentrations and temperatures on gellan biosynthesis by Sphingomonas paucimobilis ATCC 31461 were investigated. Lower sucrose concentrations and higher temperatures were favorable for cell growth. Higher sucrose concentrations and lower temperatures promoted gellan production but retarded cell growth. Based on these results, a two-stage culture strategy was developed to improve gellan production. During the first 24 h, S. paucimobilis was cultured in a pulse fed-batch mode with an initial sucrose concentration 10 g/L. Ten grams per liter of sucrose were added at 12 h and 24 h, and the temperature was controlled at 33 °C. Batch culture was performed, and the temperature was reduced to 28 °C to achieve a high gellan accumulation. The two-stage culture strategy achieved the highest gellan production (22.61 g/L) at 60 h that was 35.71% higher than the result of the best conventional batch operation (16.66 g/L). Meanwhile, high gellan yield was related to high UDPG-pyrophosphorylase activity and glucosyltransferase activity.

  10. Two-stage fermentation process for enhanced mannitol production using Candida magnoliae mutant R9.

    PubMed

    Savergave, Laxman S; Gadre, Ramchandra V; Vaidya, Bhalchandra K; Jogdand, Vitthal V

    2013-02-01

    Mutants of Candida magnoliae NCIM 3470 were generated by treatment of ultra-violet radiations, ethyl methyl sulphonate and N-methyl-N'-nitro-N-nitrosoguanidine. Mutants with higher reductase activity were screened by means of 2,3,5-triphenyl tetrazolium chloride agar plate assay. Among the screened mutants, the mutant R9 produced maximum mannitol (i.e. 46 g l(-1)) in liquid fermentation medium containing 250 g l(-1) glucose and hence was selected for further experiments. Preliminary optimization studies were carried out on shake-flask level which increased the mannitol production to 60 g l(-1) in liquid fermentation medium containing 300 g l(-1) glucose. A two-stage fermentation process comprising of growth phase and production phase was employed. During the growth phase, glucose was supplemented and aerobic conditions were maintained. Thereafter, the production phase was initiated by supplementing fructose and switching to anaerobic conditions by discontinuing aeration and decreasing the speed of agitation. The strategy of two-stage fermentation significantly enhanced the production of mannitol up to 240 g l(-1), which is the highest among all fermentative production processes and corresponds to 81 % yield and 4 g l(-1 )h(-1) productivity without formation of any by-product.

  11. Waste-gasification efficiency of a two-stage fluidized-bed gasification system.

    PubMed

    Liu, Zhen-Shu; Lin, Chiou-Liang; Chang, Tsung-Jen; Weng, Wang-Chang

    2016-02-01

    This study employed a two-stage fluidized-bed gasifier as a gasification reactor and two additives (CaO and activated carbon) as the Stage-II bed material to investigate the effects of the operating temperature (700°C, 800°C, and 900°C) on the syngas composition, total gas yield, and gas-heating value during simulated waste gasification. The results showed that when the operating temperature increased from 700 to 900°C, the molar percentage of H2 in the syngas produced by the two-stage gasification process increased from 19.4 to 29.7mol% and that the total gas yield and gas-heating value also increased. When CaO was used as the additive, the molar percentage of CO2 in the syngas decreased, and the molar percentage of H2 increased. When activated carbon was used, the molar percentage of CH4 in the syngas increased, and the total gas yield and gas-heating value increased. Overall, CaO had better effects on the production of H2, whereas activated carbon clearly enhanced the total gas yield and gas-heating value.

  12. Two-stage high temperature sludge gasification using the waste heat from hot blast furnace slags.

    PubMed

    Sun, Yongqi; Zhang, Zuotai; Liu, Lili; Wang, Xidong

    2015-12-01

    Nowadays, disposal of sewage sludge from wastewater treatment plants and recovery of waste heat from steel industry, become two important environmental issues and to integrate these two problems, a two-stage high temperature sludge gasification approach was investigated using the waste heat in hot slags herein. The whole process was divided into two stages, i.e., the low temperature sludge pyrolysis at ⩽ 900°C in argon agent and the high temperature char gasification at ⩾ 900°C in CO2 agent, during which the heat required was supplied by hot slags in different temperature ranges. Both the thermodynamic and kinetic mechanisms were identified and it was indicated that an Avrami-Erofeev model could best interpret the stage of char gasification. Furthermore, a schematic concept of this strategy was portrayed, based on which the potential CO yield and CO2 emission reduction achieved in China could be ∼1.92∗10(9)m(3) and 1.93∗10(6)t, respectively.

  13. Waste-gasification efficiency of a two-stage fluidized-bed gasification system.

    PubMed

    Liu, Zhen-Shu; Lin, Chiou-Liang; Chang, Tsung-Jen; Weng, Wang-Chang

    2016-02-01

    This study employed a two-stage fluidized-bed gasifier as a gasification reactor and two additives (CaO and activated carbon) as the Stage-II bed material to investigate the effects of the operating temperature (700°C, 800°C, and 900°C) on the syngas composition, total gas yield, and gas-heating value during simulated waste gasification. The results showed that when the operating temperature increased from 700 to 900°C, the molar percentage of H2 in the syngas produced by the two-stage gasification process increased from 19.4 to 29.7mol% and that the total gas yield and gas-heating value also increased. When CaO was used as the additive, the molar percentage of CO2 in the syngas decreased, and the molar percentage of H2 increased. When activated carbon was used, the molar percentage of CH4 in the syngas increased, and the total gas yield and gas-heating value increased. Overall, CaO had better effects on the production of H2, whereas activated carbon clearly enhanced the total gas yield and gas-heating value. PMID:26698684

  14. [Population growth rate of the rotifer Brachionus rotundiformis (Rotifera: Brachionidae) in a two-stage chemostat].

    PubMed

    Cabrera, María I

    2008-09-01

    The population growth rate of the rotifer Brachionus rotundiformis (Rotifera: Brachionidae) in two-stage chemostat. The population growth rates of Brachionus rotundiformis were estimated in two-stage chemostat cultures. Chlorella sorokiniana was supplied continuously from a steady state culture growing with constant illumination on limiting nitrate. Rotifer growth in the second stage was limited by the rate of algal supply. The algal supply rate and rotifer population growth rate were determined by the second-stage dilution rate. The maximum population growth rate in the transient state of B. rotundiformis (1.96 day(-1)) was observed at 2.5 x 10(6) cel/ml of the algae whereas in the steady state the maximum population growth rate (1.09 day(-1)) was similar to the point Hopf's bifurcation predicted by Fussmann and was observed at 1 x 10(6) cel/ml of the algae. In the transient state, the rotifer's growth rate increased and the duplication time decreased at higher algal concentrations, until reaching a peak where the population growth rate begins to decrease. In the steady state, the opposite was true. The growth rates observed in this work are among the highest recorded for this rotifer in continuous cultures.

  15. Advanced Dependent Pressure Vessel (DPV) nickel-hydrogen spacecraft cell and battery design

    NASA Technical Reports Server (NTRS)

    Coates, Dwaine; Wright, Doug; Repplinger, Ron

    1995-01-01

    The dependent pressure vessel (DPV) nickel-hydrogen (NiH2) battery is being developed as a potential spacecraft battery design for both military and commercial satellites. Individual pressure vessel (IPV) NiH2 batteries are currently flying on more than 70 Earth orbital satellites and have accumulated more than 140,000,000 cell-hours in actual spacecraft operation. The limitations of standard NiH2 IPV flight battery technology are primarily related to the internal cell design and the battery packaging issues associated with grouping multiple cylindrical cells. The DPV cell design offers higher specific energy and reduced cost, while retaining the established IPV NiH2 technology flight heritage and database. The advanced cell design offers a more efficient mechanical, electrical and thermal cell configuration and a reduced parts count. The internal electrode stack is a prismatic flat-plate arrangement. The flat individual cell pressure vessel provides a maximum direct thermal path for removing heat from the electrode stack. The cell geometry also minimizes multiple-cell battery packaging constraints by using an established end-plateltie-rod battery design. A major design advantage is that the battery support structure is efficiently required to restrain only the force applied to a portion of the end cell. As the cells are stacked in series to achieve the desired system voltage, this increment of the total battery weight becomes small. The geometry of the DPV cell promotes compact, minimum volume packaging and places all cell terminals along the length of the battery. The resulting ability to minimize intercell wiring offers additional design simplicity and significant weight savings. The DPV battery design offers significant cost and weight savings advantages while providing minimal design risks. Cell and battery level design issues will be addressed including mechanical, electrical and thermal design aspects. A design performance analysis will be presented at both

  16. The Association for the Advancement of Wound Care (AAWC) venous and pressure ulcer guidelines.

    PubMed

    Bolton, Laura L; Girolami, Sue; Corbett, Lisa; van Rijswijk, Lia

    2014-11-01

    Guidelines based on best available evidence to support pressure ulcer (PU) or venous ulcer (VU) management decisions can improve outcomes. Historically, such guidelines were consensus-based and differed in content and development methods used. Since 2002, the Association for the Advancement of Wound Care (AAWC) Guideline Task Force has used a systematic approach for developing "guidelines of guidelines" that unify and blend recommendations from relevant published guidelines while meeting Institute of Medicine and Agency for Healthcare Research and Quality standards. In addition to establishing the literature-based strength of each recommendation, guideline clinical relevance is examined using standard content validation procedures. All final recommendations included are clinically relevant and/or supported by the highest level of available evidence, cited with every recommendation. In addition, guideline implementation resources are provided. The most recent AAWC VU and PU guidelines and ongoing efforts for improving their clinical relevance are presented. The guideline development process must be transparent and guidelines must be updated regularly to maintain their relevance. In addition, end-user results and research studies to examine their construct and predictive validity are needed.

  17. The Association for the Advancement of Wound Care (AAWC) venous and pressure ulcer guidelines.

    PubMed

    Bolton, Laura L; Girolami, Sue; Corbett, Lisa; van Rijswijk, Lia

    2014-11-01

    Guidelines based on best available evidence to support pressure ulcer (PU) or venous ulcer (VU) management decisions can improve outcomes. Historically, such guidelines were consensus-based and differed in content and development methods used. Since 2002, the Association for the Advancement of Wound Care (AAWC) Guideline Task Force has used a systematic approach for developing "guidelines of guidelines" that unify and blend recommendations from relevant published guidelines while meeting Institute of Medicine and Agency for Healthcare Research and Quality standards. In addition to establishing the literature-based strength of each recommendation, guideline clinical relevance is examined using standard content validation procedures. All final recommendations included are clinically relevant and/or supported by the highest level of available evidence, cited with every recommendation. In addition, guideline implementation resources are provided. The most recent AAWC VU and PU guidelines and ongoing efforts for improving their clinical relevance are presented. The guideline development process must be transparent and guidelines must be updated regularly to maintain their relevance. In addition, end-user results and research studies to examine their construct and predictive validity are needed. PMID:25380098

  18. Two-stage unilateral versus one-stage bilateral single-port sympathectomy for palmar and axillary hyperhidrosis†

    PubMed Central

    Ibrahim, Mohsen; Menna, Cecilia; Andreetti, Claudio; Ciccone, Anna Maria; D'Andrilli, Antonio; Maurizi, Giulio; Poggi, Camilla; Vanni, Camilla; Venuta, Federico; Rendina, Erino Angelo

    2013-01-01

    OBJECTIVES Video-assisted thoracoscopic sympathectomy is currently the best treatment for palmar and axillary hyperhidrosis. It can be performed through either one or two stages of surgery. This study aimed to evaluate the operative and postoperative results of two-stage unilateral vs one-stage bilateral thoracoscopic sympathectomy. METHODS From November 1995 to February 2011, 270 patients with severe palmar and/or axillary hyperhidrosis were recruited for this study. One hundred and thirty patients received one-stage bilateral, single-port video-assisted thoracoscopic sympathectomy (one-stage group) and 140, two-stage unilateral, single-port video-assisted thoracoscopic sympathectomy, with a mean time interval of 4 months between the procedures (two-stage group). RESULTS The mean postoperative follow-up period was 12.5 (range: 1–24 months). After surgery, hands and axillae of all patients were dry and warm. Sixteen (12%) patients of the one-stage group and 15 (11%) of the two-stage group suffered from mild/moderate pain (P = 0.8482). The mean operative time was 38 ± 5 min in the one-stage group and 39 ± 8 min in the two-stage group (P = 0.199). Pneumothorax occurred in 8 (6%) patients of the one-stage group and in 11 (8%) of the two-stage group. Compensatory sweating occurred in 25 (19%) patients of the one-stage group and in 6 (4%) of the two-stage group (P = 0.0001). No patients developed Horner's syndrome. CONCLUSIONS Both two-stage unilateral and one-stage bilateral single-port video-assisted thoracoscopic sympathectomies are effective, safe and minimally invasive procedures. Two-stage unilateral sympathectomy can be performed with a lower occurrence of compensatory sweating, improving permanently the quality of life in patients with palmar and axillary hyperhidrosis. PMID:23442937

  19. A two-stage optimization model for emergency material reserve layout planning under uncertainty in response to environmental accidents.

    PubMed

    Liu, Jie; Guo, Liang; Jiang, Jiping; Jiang, Dexun; Liu, Rentao; Wang, Peng

    2016-06-01

    In the emergency management relevant to pollution accidents, efficiency emergency rescues can be deeply influenced by a reasonable assignment of the available emergency materials to the related risk sources. In this study, a two-stage optimization framework is developed for emergency material reserve layout planning under uncertainty to identify material warehouse locations and emergency material reserve schemes in pre-accident phase coping with potential environmental accidents. This framework is based on an integration of Hierarchical clustering analysis - improved center of gravity (HCA-ICG) model and material warehouse location - emergency material allocation (MWL-EMA) model. First, decision alternatives are generated using HCA-ICG to identify newly-built emergency material warehouses for risk sources which cannot be satisfied by existing ones with a time-effective manner. Second, emergency material reserve planning is obtained using MWL-EMA to make emergency materials be prepared in advance with a cost-effective manner. The optimization framework is then applied to emergency management system planning in Jiangsu province, China. The results demonstrate that the developed framework not only could facilitate material warehouse selection but also effectively provide emergency material for emergency operations in a quick response.

  20. A two-stage optimization model for emergency material reserve layout planning under uncertainty in response to environmental accidents.

    PubMed

    Liu, Jie; Guo, Liang; Jiang, Jiping; Jiang, Dexun; Liu, Rentao; Wang, Peng

    2016-06-01

    In the emergency management relevant to pollution accidents, efficiency emergency rescues can be deeply influenced by a reasonable assignment of the available emergency materials to the related risk sources. In this study, a two-stage optimization framework is developed for emergency material reserve layout planning under uncertainty to identify material warehouse locations and emergency material reserve schemes in pre-accident phase coping with potential environmental accidents. This framework is based on an integration of Hierarchical clustering analysis - improved center of gravity (HCA-ICG) model and material warehouse location - emergency material allocation (MWL-EMA) model. First, decision alternatives are generated using HCA-ICG to identify newly-built emergency material warehouses for risk sources which cannot be satisfied by existing ones with a time-effective manner. Second, emergency material reserve planning is obtained using MWL-EMA to make emergency materials be prepared in advance with a cost-effective manner. The optimization framework is then applied to emergency management system planning in Jiangsu province, China. The results demonstrate that the developed framework not only could facilitate material warehouse selection but also effectively provide emergency material for emergency operations in a quick response. PMID:26897572

  1. Two-stage atlas subset selection in multi-atlas based image segmentation

    SciTech Connect

    Zhao, Tingting Ruan, Dan

    2015-06-15

    Purpose: Fast growing access to large databases and cloud stored data presents a unique opportunity for multi-atlas based image segmentation and also presents challenges in heterogeneous atlas quality and computation burden. This work aims to develop a novel two-stage method tailored to the special needs in the face of large atlas collection with varied quality, so that high-accuracy segmentation can be achieved with low computational cost. Methods: An atlas subset selection scheme is proposed to substitute a significant portion of the computationally expensive full-fledged registration in the conventional scheme with a low-cost alternative. More specifically, the authors introduce a two-stage atlas subset selection method. In the first stage, an augmented subset is obtained based on a low-cost registration configuration and a preliminary relevance metric; in the second stage, the subset is further narrowed down to a fusion set of desired size, based on full-fledged registration and a refined relevance metric. An inference model is developed to characterize the relationship between the preliminary and refined relevance metrics, and a proper augmented subset size is derived to ensure that the desired atlases survive the preliminary selection with high probability. Results: The performance of the proposed scheme has been assessed with cross validation based on two clinical datasets consisting of manually segmented prostate and brain magnetic resonance images, respectively. The proposed scheme demonstrates comparable end-to-end segmentation performance as the conventional single-stage selection method, but with significant computation reduction. Compared with the alternative computation reduction method, their scheme improves the mean and medium Dice similarity coefficient value from (0.74, 0.78) to (0.83, 0.85) and from (0.82, 0.84) to (0.95, 0.95) for prostate and corpus callosum segmentation, respectively, with statistical significance. Conclusions: The authors

  2. Two-Stage Energy Thermalization Mechanism in Nanosecond Pulse Discharges in Air and Hydrogen-Air Mixtures

    NASA Astrophysics Data System (ADS)

    Shkurenkov, Ivan; Lanier, Suzanne; Adamovich, Igor; Lempert, Walter

    2014-10-01

    Time-resolved and spatially resolved rotational temperature measurements in air and H2-air, by purely rotational Coherent Anti-Stokes Raman Spectroscopy (CARS), are presented. The experimental results demonstrate high accuracy of pure rotational psec CARS for thermometry measurements at low partial pressures of oxygen in nonequilibrium plasmas. The results are compared with modeling calculations using a state-specific master equation kinetic model of reacting hydrogen-air plasmas, showing good agreement. The results demonstrate that energy thermalization and temperature rise in these plasmas occur in two stages, (i) ``rapid'' heating, occurring on the time scale τrapid ~ 0 . 1 --1 μs .atm, caused by collisional quenching of excited electronic states of N2 molecules by O2, and (ii) ``slow'' heating, on the time scale τslow ~ 10 --100 μs .atm, caused primarily by N2 vibrational relaxation by O atoms (in air) and by chemical energy release during partial oxidation of hydrogen (in H2-air. Both energy thermalization mechanisms have major implications for plasma assisted combustion and plasma flow control.

  3. The Importance of Detailed Component Simulations in the Feedsystem Development for a Two-Stage-to Orbit Reusable Launch Vehicle

    NASA Technical Reports Server (NTRS)

    Mazurkivich, Pete; Chandler, Frank; Grayson, Gary

    2005-01-01

    To meet the requirements for the 2nd Generation Reusable Launch Vehicle (RLV), a unique propulsion feed system concept was identified using crossfeed between the booster and orbiter stages that could reduce the Two-Stage-to-Orbit (TSTO) vehicle weight and development cost by approximately 25%. A Main Propulsion System (MPS) crossfeed water demonstration test program was configured to address all the activities required to reduce the risks for the MPS crossfeed system. A transient, one-dimensional system simulation was developed for the subscale crossfeed water flow tests. To ensure accurate representation of the crossfeed valve's dynamics in the system model, a high-fidelity, three-dimensional, computational fluid-dynamics (CFD) model was employed. The results from the CFD model were used to specify the valve's flow characteristics in the system simulation. This yielded a crossfeed system model that was anchored to the specific valve hardware and achieved good agreement with the measured test data. These results allowed the transient models to be correlated and validated and used for full scale mission predictions. The full scale model simulations indicate crossfeed is ' viable with the system pressure disturbances at the crossfeed transition being less than experienced by the propulsion system during engine start and shutdown transients.

  4. Hydrogen pellet acceleration with a two-stage system consisting of a gas gun and a fuseless electromagnetic railgun

    SciTech Connect

    Honig, J.; Kim, K.; Wedge, S.W.

    1986-05-01

    Hydrogen pellets are successfully accelerated for the first time using a two-stage system consisting of a pneumatic gun and an electromagnetic railgun. The pneumatic gun preaccelerator forms cylindrical hydrogen ice pellets (1.6-mm diam x 2.15-mm long) and accelerates them with high-pressure helium gas to velocities in excess of 500 m/s. The booster accelerator, which is a fuseless, circular-bore electromagnetic railgun, derives its propulsive force from a plasma arc armature. The plasma arc armature is formed by electrically breaking down the propellant gas which follows the pellet from the gas gun into the railgun. The diagnostics are for the monitoring of the main capacitor bank and rail currents, for the pellet detection and velocity measurements at the breech and muzzle ends of the railgun, for the recording of the plasma-arc-armature movement inside the railgun bore, and for the photographing of the hydrogen pellet exiting the railgun. Using the system, which is a 60-cm long proof-of-principle machine for refueling magnetic fusion devices, hyrogen pellet velocities exceeding 1 km/s have been achieved for pellets exiting the gas gun at velocities of approx.500 m/s.

  5. A two-stage enzymatic synthesis of conductive poly(3,4-ethylenedioxythiophene).

    PubMed

    Wang, Jing; Fang, Bai-Shan; Chou, Kuang-Ying; Chen, Chien-Chung; Gu, Yesong

    2014-01-10

    The conductive polymer, poly(3,4-ethylenedioxythiophene) (PEDOT), possesses attractive properties that show the potential applications in many fields. In this study, we have proposed a two-stage enzymatic synthesis of conductive PEDOT. Horseradish peroxidase (HRP) acts as the catalyst to promote the generation of EDOT free radicals followed by the polymerization under the room temperature in the presence of poly(sodium 4-styrenesulfonate) (PSS), then a mild heating process is employed for further chain extension. The final PEDOT:PSS is purified with n-butanol and subjected to various characterizations, which indicate that PEDOT with enzymatic approach exhibits a similar molecular structure to that with chemical method. However, the enzymatically synthesized PEDOT:PSS demonstrates advantages, such as stable integration of PEDOT with PSS and better electrochemical properties, suggesting its future prospective applications. PMID:24267567

  6. Aeroheating Characteristics for a Two-Stage-To-Orbit Concept During Separation at Mach 6

    NASA Technical Reports Server (NTRS)

    Liechty, Derek S.

    2005-01-01

    An experimental study was conducted to determine the proximity aeroheating characteristics for a two-stage-to-orbit concept in close proximity in the NASA Langley 20-Inch Mach 6 Air Tunnel. A new hybrid discrete thin-film resistance gauge technique was evaluated in this study and used to measure experimental interference heating levels between the booster and the orbiter at a constant freestream Reynolds number of 8.25 x 10(exp 6)/m and a variety of separation and axial offset distances. It was found that, as the orbiter separates from the booster and the booster falls away, the windward centerline heating increased on the orbiter by as much as 13-times over the baseline, single model heating distribution, and on the booster by as much as 6-times. The aeroheating database developed can be used for computational fluid dynamic code validation.

  7. Overview of the Beta II Two-Stage-To-Orbit vehicle design

    NASA Astrophysics Data System (ADS)

    Plencner, Robert M.

    1991-10-01

    A study of a near-term, low risk two-stage-to-orbit (TSTO) vehicle was undertaken. The goal of the study was to assess a fully reusable TSTO vehicle with horizontal takeoff and landing capability that could deliver 10,000 pounds to a 120 nm polar orbit. The configuration analysis was based on the Beta vehicle design. A cooperative study was performed to redesign and refine the Beta concept to meet the mission requirements. The vehicle resulting from this study was named Beta II. It has an all-airbreathing first stage and a staging Mach number of 6.5. The second stage is a conventional wing-body configuration with a single SSME.

  8. Two-stage dilute-acid and organic-solvent lignocellulosic pretreatment for enhanced bioprocessing.

    PubMed

    Brodeur, G; Telotte, J; Stickel, J J; Ramakrishnan, S

    2016-11-01

    A two stage pretreatment approach for biomass is developed in the current work in which dilute acid (DA) pretreatment is followed by a solvent based pretreatment (N-methyl morpholine N oxide - NMMO). When the combined pretreatment (DAWNT) is applied to sugarcane bagasse and corn stover, the rates of hydrolysis and overall yields (>90%) are seen to dramatically improve and under certain conditions 48h can be taken off the time of hydrolysis with the additional NMMO step to reach similar conversions. DAWNT shows a 2-fold increase in characteristic rates and also fractionates different components of biomass - DA treatment removes the hemicellulose while the remaining cellulose is broken down by enzymatic hydrolysis after NMMO treatment to simple sugars. The remaining residual solid is high purity lignin. Future work will focus on developing a full scale economic analysis of DAWNT for use in biomass fractionation. PMID:27631703

  9. Two-stage acceleration of interstellar ions driven by high-energy lepton plasma flows

    NASA Astrophysics Data System (ADS)

    Cui, YunQian; Sheng, ZhengMing; Lu, QuanMing; Li, YuTong; Zhang, Jie

    2015-10-01

    We present the particle-in-cell (PIC) simulation results of the interaction of a high-energy lepton plasma flow with background electron-proton plasma and focus on the acceleration processes of the protons. It is found that the acceleration follows a two-stage process. In the first stage, protons are significantly accelerated transversely (perpendicular to the lepton flow) by the turbulent magnetic field "islands" generated via the strong Weibel-type instabilities. The accelerated protons shows a perfect inverse-power energy spectrum. As the interaction continues, a shockwave structure forms and the protons in front of the shockwave are reflected at twice of the shock speed, resulting in a quasi-monoenergetic peak located near 200 MeV under the simulation parameters. The presented scenario of ion acceleration may be relevant to cosmic-ray generation in some astrophysical environments.

  10. Design and Experimental Performance of a Two Stage Partial Admission Turbine, Task B.1/B.4

    NASA Technical Reports Server (NTRS)

    Sutton, R. F.; Boynton, J. L.; Akian, R. A.; Shea, Dan; Roschak, Edmund; Rojas, Lou; Orr, Linsey; Davis, Linda; King, Brad; Bubel, Bill

    1992-01-01

    A three-inch mean diameter, two-stage turbine with partial admission in each stage was experimentally investigated over a range of admissions and angular orientations of admission arcs. Three configurations were tested in which first stage admission varied from 37.4 percent (10 of 29 passages open, 5 per side) to 6.9 percent (2 open, 1 per side). Corresponding second stage admissions were 45.2 percent (14 of 31 passages open, 7 per side) and 12.9 percent (4 open, 2 per side). Angular positions of the second stage admission arcs with respect to the first stage varied over a range of 70 degrees. Design and off-design efficiency and flow characteristics for the three configurations are presented. The results indicated that peak efficiency and the corresponding isentropic velocity ratio decreased as the arcs of admission were decreased. Both efficiency and flow characteristics were sensitive to the second stage nozzle orientation angles.

  11. Lossless and near-lossless digital angiography coding using a two-stage motion compensation approach.

    PubMed

    dos Santos, Rafael A P; Scharcanski, Jacob

    2008-07-01

    This paper presents a two-stage motion compensation coding scheme for image sequences in hemodynamics. The first stage of the proposed method implements motion compensation, and the second stage corrects local pixel intensity distortions with a context adaptive linear predictor. The proposed method is robust to the local intensity distortions and the noise that often degrades these image sequences, providing lossless and near-lossless quality. Our experiments with lossless compression of 12bits/pixel studies indicate that, potentially, our approach can perform 3.8%, 2% and 1.6% better than JPEG-2000, JPEG-LS and the method proposed by Scharcanski [1], respectively. The performance tends to improve for near-lossless compression. Therefore, this work presents experimental evidence that for coding image sequences in hemodynamics, an adequate motion compensation scheme can be more efficient than the still-image coding methods often used nowadays.

  12. The two stages hierarchical unsupervised learning system for complex dynamic scene recognition

    NASA Astrophysics Data System (ADS)

    Graham, James; O'Connor, Alan; Ternovskiy, Igor V.; Ilin, Roman

    2013-06-01

    The two stage hierarchical unsupervised learning system has been proposed for modeling complex dynamic surveillance and cyberspace systems. Using a modification of the expectation maximization learning approach, we introduced a three layer approach to learning concepts from input data: features, objects, and situations. Using the Bernoulli model, this approach models each situation as a collection of objects, and each object as a collection of features. Further complexity is added with the addition of clutter features and clutter objects. During the learning process, at the lowest level, only binary feature information (presence or absence) is provided. The system attempts to simultaneously determine the probabilities of the situation and presence of corresponding objects from the detected features. The proposed approach demonstrated robust performance after a short training period. This paper discusses this hierarchical learning system in a broader context of different feedback mechanisms between layers and highlights challenges on the road to practical applications.

  13. Design of a Two-stage High-capacity Stirling Cryocooler Operating below 30K

    NASA Astrophysics Data System (ADS)

    Wang, Xiaotao; Dai, Wei; Zhu, Jian; Chen, Shuai; Li, Haibing; Luo, Ercang

    The high capacity cryocooler working below 30K can find many applications such as superconducting motors, superconducting cables and cryopump. Compared to the GM cryocooler, the Stirling cryocooler can achieve higher efficiency and more compact structure. Because of these obvious advantages, we have designed a two stage free piston Stirling cryocooler system, which is driven by a moving magnet linear compressor with an operating frequency of 40 Hz and a maximum 5 kW input electric power. The first stage of the cryocooler is designed to operate in the liquid nitrogen temperature and output a cooling power of 100 W. And the second stage is expected to simultaneously provide a cooling power of 50 W below the temperature of 30 K. In order to achieve the best system efficiency, a numerical model based on the thermoacoustic model was developed to optimize the system operating and structure parameters.

  14. Two stages of parafoveal processing during reading: Evidence from a display change detection task.

    PubMed

    Angele, Bernhard; Slattery, Timothy J; Rayner, Keith

    2016-08-01

    We used a display change detection paradigm (Slattery, Angele, & Rayner Human Perception and Performance, 37, 1924-1938 2011) to investigate whether display change detection uses orthographic regularity and whether detection is affected by the processing difficulty of the word preceding the boundary that triggers the display change. Subjects were significantly more sensitive to display changes when the change was from a nonwordlike preview than when the change was from a wordlike preview, but the preview benefit effect on the target word was not affected by whether the preview was wordlike or nonwordlike. Additionally, we did not find any influence of preboundary word frequency on display change detection performance. Our results suggest that display change detection and lexical processing do not use the same cognitive mechanisms. We propose that parafoveal processing takes place in two stages: an early, orthography-based, preattentional stage, and a late, attention-dependent lexical access stage.

  15. Experimental and modeling study of a two-stage pilot scale high solid anaerobic digester system.

    PubMed

    Yu, Liang; Zhao, Quanbao; Ma, Jingwei; Frear, Craig; Chen, Shulin

    2012-11-01

    This study established a comprehensive model to configure a new two-stage high solid anaerobic digester (HSAD) system designed for highly degradable organic fraction of municipal solid wastes (OFMSW). The HSAD reactor as the first stage was naturally separated into two zones due to biogas floatation and low specific gravity of solid waste. The solid waste was retained in the upper zone while only the liquid leachate resided in the lower zone of the HSAD reactor. Continuous stirred-tank reactor (CSTR) and advective-diffusive reactor (ADR) models were constructed in series to describe the whole system. Anaerobic digestion model No. 1 (ADM1) was used as reaction kinetics and incorporated into each reactor module. Compared with the experimental data, the simulation results indicated that the model was able to well predict the pH, volatile fatty acid (VFA) and biogas production.

  16. A Two-Stage Probabilistic Approach to Manage Personal Worklist in Workflow Management Systems

    NASA Astrophysics Data System (ADS)

    Han, Rui; Liu, Yingbo; Wen, Lijie; Wang, Jianmin

    The application of workflow scheduling in managing individual actor's personal worklist is one area that can bring great improvement to business process. However, current deterministic work cannot adapt to the dynamics and uncertainties in the management of personal worklist. For such an issue, this paper proposes a two-stage probabilistic approach which aims at assisting actors to flexibly manage their personal worklists. To be specific, the approach analyzes every activity instance's continuous probability of satisfying deadline at the first stage. Based on this stochastic analysis result, at the second stage, an innovative scheduling strategy is proposed to minimize the overall deadline violation cost for an actor's personal worklist. Simultaneously, the strategy recommends the actor a feasible worklist of activity instances which meet the required bottom line of successful execution. The effectiveness of our approach is evaluated in a real-world workflow management system and with large scale simulation experiments.

  17. A two-stage approach to removing noise from recorded music

    NASA Astrophysics Data System (ADS)

    Berger, Jonathan; Goldberg, Maxim J.; Coifman, Ronald C.; Goldberg, Maxim J.; Coifman, Ronald C.

    2001-05-01

    A two-stage algorithm for removing noise from recorded music signals (first proposed in Berger et al., ICMC, 1995) is described and updated. The first stage selects the ``best'' local trigonometric basis for the signal and models noise as the part having high entropy [see Berger et al., J. Audio Eng. Soc. 42(10), 808-818 (1994)]. In the second stage, the original source and the model of the noise obtained from the first stage are expanded into dyadic trees of smooth local sine bases. The best basis for the source signal is extracted using a relative entropy function (the Kullback-Leibler distance) to compare the sum of the costs of the children nodes to the cost of their parent node; energies of the noise in corresponding nodes of the model noise tree are used as weights. The talk will include audio examples of various stages of the method and proposals for further research.

  18. Antigenotoxicity and antioxidant activity of Acerola fruit (Malpighia glabra L.) at two stages of ripeness.

    PubMed

    Nunes, Roberta da Silva; Kahl, Vivian Francília Silva; Sarmento, Merielen da Silva; Richter, Marc François; Costa-Lotufo, Letícia Veras; Rodrigues, Felipe Augusto Rocha; Abin-Carriquiry, Juan Andres; Martinez, Marcela María; Ferronatto, Scharline; Ferraz, Alexandre de Barros Falcão; da Silva, Juliana

    2011-06-01

    Genotoxic and antigenotoxic effects of acerola fruit at two stages of ripeness were investigated using mice blood cells. The results show that no ripeness stage of acerola extracts presented any genotoxic potential to damage DNA (Comet assay) or cytotoxicity (MTT assay). When antigenotoxic activity was analyzed, unripe fruit presented higher DNA protection than ripe fruit (red color) extract. The antioxidant capacity of substances also showed that unripe samples inhibit the free radical DPPH more significantly than the ripe ones. The results about determination of compounds made using HPLC showed that unripe acerola presents higher levels of vitamin C as compared to ripe acerola. Thus, vitamin C and the complex mixture of nutrients of Malpighia glabra L., and especially its ripeness stages, influenced the interaction of the fruit extract with the DNA. Acerola is usually consumed when ripe (red fruit), although it is the green fruit (unripe) that has higher potential as beneficial to DNA, protecting it against oxidative stress.

  19. Treatment of Ammonia Nitrogen Wastewater in Low Concentration by Two-Stage Ozonization.

    PubMed

    Luo, Xianping; Yan, Qun; Wang, Chunying; Luo, Caigui; Zhou, Nana; Jian, Chensheng

    2015-09-23

    Ammonia nitrogen wastewater (about 100 mg/L) was treated by two-stage ozone oxidation method. The effects of ozone flow rate and initial pH on ammonia removal were studied, and the mechanism of ammonia nitrogen removal by ozone oxidation was discussed. After the primary stage of ozone oxidation, the ammonia removal efficiency reached 59.32% and pH decreased to 6.63 under conditions of 1 L/min ozone flow rate and initial pH 11. Then, the removal efficiency could be over 85% (the left ammonia concentration was lower than 15 mg/L) after the second stage, which means the wastewater could have met the national discharge standards of China. Besides, the mechanism of ammonia removal by ozone oxidation was proposed by detecting the products of the oxidation: ozone oxidation directly and ·OH oxidation; ammonia was mainly transformed into NO₃(-)-N, less into NO₂(-)-N, not into N₂.

  20. Fundamental two-stage formulation for Bayesian system identification, Part II: Application to ambient vibration data

    NASA Astrophysics Data System (ADS)

    Zhang, Feng-Liang; Au, Siu-Kui

    2016-01-01

    A fundamental theory has been developed for a general two-stage Bayesian system identification problem in the companion paper (Part I). This paper applies the theory to the particular case of structural system identification using ambient vibration data. In Stage I, the modal properties are identified using the Fast Bayesian FFT method. Given the data, their posterior distribution can be well approximated by a Gaussian distribution whose mean and covariance matrix can be computed efficiently. In Stage II, the structural model parameters (e.g., stiffness, mass) are identified incorporating the posterior distribution of the natural frequencies and mode shapes in Stage I and their conditional distribution based on the theoretical structural finite element model. Synthetic and experimental data are used to illustrate the proposed theory and applications. A number of factors commonly relevant to structural system identification are studied, including the number of measured degrees of freedom, the number of identifiable modes and sensor alignment error.

  1. Two-stage dilute-acid and organic-solvent lignocellulosic pretreatment for enhanced bioprocessing.

    PubMed

    Brodeur, G; Telotte, J; Stickel, J J; Ramakrishnan, S

    2016-11-01

    A two stage pretreatment approach for biomass is developed in the current work in which dilute acid (DA) pretreatment is followed by a solvent based pretreatment (N-methyl morpholine N oxide - NMMO). When the combined pretreatment (DAWNT) is applied to sugarcane bagasse and corn stover, the rates of hydrolysis and overall yields (>90%) are seen to dramatically improve and under certain conditions 48h can be taken off the time of hydrolysis with the additional NMMO step to reach similar conversions. DAWNT shows a 2-fold increase in characteristic rates and also fractionates different components of biomass - DA treatment removes the hemicellulose while the remaining cellulose is broken down by enzymatic hydrolysis after NMMO treatment to simple sugars. The remaining residual solid is high purity lignin. Future work will focus on developing a full scale economic analysis of DAWNT for use in biomass fractionation.

  2. Flexible design of two-stage adaptive procedures for phase III clinical trials.

    PubMed

    Koyama, Tatsuki

    2007-07-01

    The recent popularity of two-stage adaptive designs has fueled a number of proposals for their use in phase III clinical trials. Many of these designs assign certain restrictive functional forms to the design elements of stage 2, such as sample size, critical value and conditional power functions. We propose a more flexible method of design without imposing any particular functional forms on these design elements. Our methodology permits specification of a design based on either conditional or unconditional characteristics, and allows accommodation of sample size limit. Furthermore, we show how to compute the P value, confidence interval and a reasonable point estimate for any design that can be placed under the proposed framework. PMID:17307399

  3. Two-stage Raman compression of laser pulses with controllable phase fronts

    SciTech Connect

    Balakin, A. A.; Fraiman, G. M.; Dodin, I. Y.

    2015-05-15

    The phase front of an ultrashort laser pulse undergoing Raman amplification and compression in inhomogeneous plasma can be controlled such that it is unaffected by density gradients and thus remains focusable. This is achieved by performing the Raman backscattering in two stages. At the first stage, the standard nonlinear Raman compression of a seed wave takes place and produces a short ultraintense pulse, which yet may be poorly focusable. At the second stage, this amplified pulse is scattered again, now serving as a pump, off a second copy of the initial seed. This stage, which utilizes a denser and shorter plasma, is intended not for compression but rather for passing a significant fraction of the energy to the second seed quickly. Then, the output pulse that is produced is not just short and ultraintense, but also has the smooth phase front of the original seed.

  4. Two-stage models for lunar and terrestrial anorthosites Petrogenesis without a magma ocean

    NASA Astrophysics Data System (ADS)

    Longhi, J.; Ashwal, L. D.

    1985-02-01

    The most popular model of early lunar differentiation is that of a globe-encircling magma ocean tens, if not hundreds, of kilometers deep which produced a floating anorthositic crust and a complementary plagioclase-depleted interior during solidification. Shirley (1983) attempted to show a process by which some of the oldest rocks, lunar ferroan anorthosites (LFA), might have formed from a partially molten 'magma ocean'. The present investigation is concerned with a process by which ferroan anorthosites might have formed without a magma ocean. Attention is given to the magma ocean hypothesis, a hypothesis proposed by Wetherill (1975) regarding a petrogenesis without a magma ocean, two-stage lunar anorthosites, and terrestrial anorthosites.

  5. Two stages of parafoveal processing during reading: Evidence from a display change detection task.

    PubMed

    Angele, Bernhard; Slattery, Timothy J; Rayner, Keith

    2016-08-01

    We used a display change detection paradigm (Slattery, Angele, & Rayner Human Perception and Performance, 37, 1924-1938 2011) to investigate whether display change detection uses orthographic regularity and whether detection is affected by the processing difficulty of the word preceding the boundary that triggers the display change. Subjects were significantly more sensitive to display changes when the change was from a nonwordlike preview than when the change was from a wordlike preview, but the preview benefit effect on the target word was not affected by whether the preview was wordlike or nonwordlike. Additionally, we did not find any influence of preboundary word frequency on display change detection performance. Our results suggest that display change detection and lexical processing do not use the same cognitive mechanisms. We propose that parafoveal processing takes place in two stages: an early, orthography-based, preattentional stage, and a late, attention-dependent lexical access stage. PMID:26769246

  6. Enhanced biodiesel production in Neochloris oleoabundans by a semi-continuous process in two stage photobioreactors.

    PubMed

    Yoon, Se Young; Hong, Min Eui; Chang, Won Seok; Sim, Sang Jun

    2015-07-01

    Under autotrophic conditions, highly productive biodiesel production was achieved using a semi-continuous culture system in Neochloris oleoabundans. In particular, the flue gas generated by combustion of liquefied natural gas and natural solar radiation were used for cost-effective microalgal culture system. In semi-continuous culture, the greater part (~80%) of the culture volume containing vegetative cells grown under nitrogen-replete conditions in a first photobioreactor (PBR) was directly transferred to a second PBR and cultured sequentially under nitrogen-deplete conditions for accelerating oil accumulation. As a result, in semi-continuous culture, the productivities of biomass and biodiesel in the cells were increased by 58% (growth phase) and 51% (induction phase) compared to the cells in batch culture, respectively. The semi-continuous culture system using two stage photobioreactors is a very efficient strategy to further improve biodiesel production from microalgae under photoautotrophic conditions.

  7. Enhanced biodiesel production in Neochloris oleoabundans by a semi-continuous process in two stage photobioreactors.

    PubMed

    Yoon, Se Young; Hong, Min Eui; Chang, Won Seok; Sim, Sang Jun

    2015-07-01

    Under autotrophic conditions, highly productive biodiesel production was achieved using a semi-continuous culture system in Neochloris oleoabundans. In particular, the flue gas generated by combustion of liquefied natural gas and natural solar radiation were used for cost-effective microalgal culture system. In semi-continuous culture, the greater part (~80%) of the culture volume containing vegetative cells grown under nitrogen-replete conditions in a first photobioreactor (PBR) was directly transferred to a second PBR and cultured sequentially under nitrogen-deplete conditions for accelerating oil accumulation. As a result, in semi-continuous culture, the productivities of biomass and biodiesel in the cells were increased by 58% (growth phase) and 51% (induction phase) compared to the cells in batch culture, respectively. The semi-continuous culture system using two stage photobioreactors is a very efficient strategy to further improve biodiesel production from microalgae under photoautotrophic conditions. PMID:25740458

  8. Two-stage electron acceleration by simultaneous stimulated Raman backward and forward scattering

    SciTech Connect

    Bertrand, P.; Ghizzo, A.; Karttunen, S.J.; Paettikangas, T.J.H.; Salomaa, R.R.E.; Shoucri, M.

    1995-08-01

    The coexistence of stimulated Raman forward and backward scattering of intense electromagnetic radiation, which can occur, for instance, in laser fusion plasmas, is investigated. The simultaneous Raman forward and backward scattering is shown to create an electrostatic field structure which is exceptionally efficient in producing highly relativistic electrons. The mechanism of the electron acceleration is analyzed both by Vlasov--Maxwell simulations with self-consistent fields and by test particle calculations with prescribed electrostatic fields. The Vlasov--Maxwell simulations reveal that the two plasma waves generated by the backward and forward scattering are spatially separated, and thus form a two-stage electron ``accelerator.`` {copyright} {ital 1995} {ital American} {ital Institute} {ital of} {ital Physics}.

  9. Two-stage sparse representation-based face recognition with reconstructed images

    NASA Astrophysics Data System (ADS)

    Cheng, Guangtao; Song, Zhanjie; Lei, Yang; Han, Xiuning

    2014-09-01

    In order to address the challenges that both the training and testing images are contaminated by random pixels corruption, occlusion, and disguise, a robust face recognition algorithm based on two-stage sparse representation is proposed. Specifically, noises in the training images are first eliminated by low-rank matrix recovery. Then, by exploiting the first-stage sparse representation computed by solving a new extended ℓ1-minimization problem, noises in the testing image can be successfully removed. After the elimination, feature extraction techniques that are more discriminative but are sensitive to noise can be effectively performed on the reconstructed clean images, and the final classification is accomplished by utilizing the second-stage sparse representation obtained by solving the reduced ℓ1-minimization problem in a low-dimensional feature space. Extensive experiments are conducted on publicly available databases to verify the superiority and robustness of our algorithm.

  10. Inexact rough-interval two-stage stochastic programming for conjunctive water allocation problems.

    PubMed

    Lu, Hongwei; Huang, Guohe; He, Li

    2009-10-01

    An inexact rough-interval two-stage stochastic programming (IRTSP) method is developed for conjunctive water allocation problems. Rough intervals (RIs), as a particular case of rough sets, are introduced into the modeling framework to tackle dual-layer information provided by decision makers. Through embeding upper and lower approximation intervals, rough intervals are capable of reflecting complex parameters with the most reliable and possible variation ranges being identified. An interactive solution method is also derived. A conjunctive water-allocation system is then structured for characterizing the proposed model. Solutions indicate a detailed optimal allocation scheme with a rough-interval form; a total of [[1048.83, 2078.29]:[1482.26, 2020.60

  11. Sporadic gastric carcinoid tumor successfully treated by two-stage laparoscopic surgery: A case report

    PubMed Central

    Kinoshita, Takahiro; Oshiro, Takashi; Urita, Tasuku; Yoshida, Yutaka; Ooshiro, Mitsuru; Okazumi, Shinichi; Katoh, Ryoji; Sasai, Daisuke; Hiruta, Nobuyuki

    2010-01-01

    We report a case of sporadic gastric carcinoid tumor successfully treated by two-stage laparoscopic surgery. A 38-year old asymptomatic woman was referred to our hospital for evaluation of a submucosal tumor of the stomach. Endoscopic examination showed a solitary submucosal tumor without ulceration or central depression on the posterior wall of the antrum and biopsy specimens were not sufficient to determine the diagnosis. Endoscopic ultrasound revealed a tumor nearly 2 cm in diameter arising from the muscle layer and a computed tomography scan showed the tumor enhanced in the arterial phase. Laparoscopic wedge resection was performed for definitive diagnosis. Pathologically, the tumor was shown to be gastric carcinoid infiltrating the muscle layer which indicated the probability of lymph node metastasis. Serum gastrin levels were normal. As a radical treatment, laparoscopy-assisted distal gastrectomy with regional lymphadenectomy was performed 3 wk after the initial surgery. Finally, pathological examination revealed no lymph node metastasis. PMID:21160902

  12. Two-stage Surgery for an Aortoesophageal Fistula Caused by Tuberculous Esophagitis

    PubMed Central

    Choi, Chang Woo; Lim, Jae Woong; Her, Keun

    2015-01-01

    An aortoesophageal fistula (AEF) is an extremely rare, potentially fatal condition, and aortic surgery is usually performed together with extracorporeal circulation. However, this surgical method has a high rate of surgical complications and mortality. This report describes an AEF caused by tuberculous esophagitis that was treated successfully using a two-stage operation. A 52-yr-old man was admitted to the hospital with severe hematemesis and syncope. Based on the computed tomography and diagnostic endoscopic findings, he was diagnosed with an AEF and initially underwent thoracic endovascular aortic repair. Esophageal reconstruction was performed after controlling the mediastinal inflammation. The patient suffered postoperative anastomotic leakage, which was treated by an endoscopic procedure, and the patient was discharged without any further problems. The patient received 9 months of anti-tuberculosis treatment after he was diagnosed with histologically confirmed tuberculous esophagitis; subsequently, he was followed as an outpatient and has had no recurrence of the tuberculosis or any further issues. PMID:26539019

  13. Acetic acid effects on methanogens in the second stage of a two-stage anaerobic system.

    PubMed

    Xiao, Keke; Guo, Chenghong; Zhou, Yan; Maspolim, Yogananda; Ng, Wun-Jern

    2016-02-01

    This study reports on biomass tolerance towards high concentrations of acetic acid (HAc) within the system. Biomass from the second stage of a two-stage anaerobic sludge digestion system was used for this study. Microbial community analysis by 454 pyrosequencing highlighted hydrogenotrophic Methanomicrobiales was the predominant archaeal population in the second stage (>99% of the total archaeal community). Second stage biomass degraded HAc up to 4200 mg HAc L(-1) without observable lag phase. However, at HAc-shock loading of 7400 mg HAc L(-1), it showed a one day lag phase associated with decreased biomass activity. After stepwise HAc-acclimation over 27 d, the biomass degraded HAc of up to 8200 mg HAc L(-1) without observable lag phase. The dominance of Methanomicrobiales had remained unchanged in proportion - while the total archaeal population increased during acclimation. This study showed stepwise acclimation could be an approach to accommodate HAc accumulation and hence higher concentrations resulting from an enhanced first stage.

  14. Two-stage reflective optical system for achromatic 10 nm x-ray focusing

    NASA Astrophysics Data System (ADS)

    Motoyama, Hiroto; Mimura, Hidekazu

    2015-12-01

    Recently, coherent x-ray sources have promoted developments of optical systems for focusing, imaging, and interferometers. In this paper, we propose a two-stage focusing optical system with the goal of achromatically focusing pulses from an x-ray free-electron laser (XFEL), with a focal width of 10 nm. In this optical system, the x-ray beam is expanded by a grazing-incidence aspheric mirror, and it is focused by a mirror that is shaped as a solid of revolution. We describe the design procedure and discuss the theoretical focusing performance. In theory, soft-XFEL lights can be focused to a 10 nm area without chromatic aberration and with high reflectivity; this creates an unprecedented power density of 1020 W cm-2 in the soft-x-ray range.

  15. Study of a two-stage photobase generator for photolithography in microelectronics.

    PubMed

    Turro, Nicholas J; Li, Yongjun; Jockusch, Steffen; Hagiwara, Yuji; Okazaki, Masahiro; Mesch, Ryan A; Schuster, David I; Willson, C Grant

    2013-03-01

    The investigation of the photochemistry of a two-stage photobase generator (PBG) is described. Absorption of a photon by a latent PBG (1) (first step) produces a PBG (2). Irradiation of 2 in the presence of water produces a base (second step). This two-photon sequence (1 + hν → 2 + hν → base) is an important component in the design of photoresists for pitch division technology, a method that doubles the resolution of projection photolithography for the production of microelectronic chips. In the present system, the excitation of 1 results in a Norrish type II intramolecular hydrogen abstraction to generate a 1,4-biradiacal that undergoes cleavage to form 2 and acetophenone (Φ ∼ 0.04). In the second step, excitation of 2 causes cleavage of the oxime ester (Φ = 0.56) followed by base generation after reaction with water.

  16. Two-stage SQUID systems and transducers development for MiniGRAIL

    NASA Astrophysics Data System (ADS)

    Gottardi, L.; Podt, M.; Bassan, M.; Flokstra, J.; Karbalai-Sadegh, A.; Minenkov, Y.; Reinke, W.; Shumack, A.; Srinivas, S.; de Waard, A.; Frossati, G.

    2004-03-01

    We present measurements on a two-stage SQUID system based on a dc-SQUID as a sensor and a DROS as an amplifier. We measured the intrinsic noise of the dc-SQUID at 4.2 K. A new dc-SQUID has been fabricated. It was specially designed to be used with MiniGRAIL transducers. Cooling fins have been added in order to improve the cooling of the SQUID and the design is optimized to achieve the quantum limit of the sensor SQUID at temperatures above 100 mK. In this paper we also report the effect of the deposition of a Nb film on the quality factor of a small mass Al5056 resonator. Finally, the results of Q-factor measurements on a capacitive transducer for the current MiniGRAIL run are presented.

  17. Simplified two-stage method to B-phycoerythrin recovery from Porphyridium cruentum.

    PubMed

    Benavides, Jorge; Rito-Palomares, Marco

    2006-11-21

    A simplified two-stage method for B-phycoerythrin (BPE) recovery from Porphyridium cruentum was developed. The proposed method involved cell disruption by sonication and primary recovery by aqueous two-phase partition. The evaluation of two different methods of cell disruption and the effect of increasing concentration of cell homogenate from P. cruentum culture upon aqueous two-phase systems (ATPS) performance was carried out to avoid the use of precipitation stages. Cell disruption by sonication proved to be superior over manual maceration since a five time increase in the concentration of B-phycoerythrin release was achieved. An increase in the concentration of crude extract from disrupted P. cruentum cells loaded to the ATPS (from 10 to 40%, w/w) proved to be suitable to increase the product purity and benefited the processing of highly concentrated disrupted extract. Kinetics studies of phase separation performed suggested the use of batch settlers with height/diameter (H/D) ratio less than one to reduce the necessary time for the phases to separate. The proposed ATPS stage comprising of 29% (w/w) polyethylene glycol (PEG) 1000g/mol, 9% (w/w) potassium phosphate, tie-line length (TLL) of 45% (w/w), volume ratio (V(R)) of 4.5, pH 7.0 and 40% (w/w) crude extract loaded in a batch settler with H/D ratio of 0.5 proved to be efficient for the recovery of 90% of B-phycoerythrin at the top PEG-rich phase. The purity of B-phycoerythrin increased up to 4.0 times after the two-stage method. The results reported here demonstrate the potential implementation of a strategy to B-phycoerythrin recovery with a purity of 3.2 (estimated by the absorbance relation of 545-280nm) from P. cruentum.

  18. Novel two-stage piezoelectric-based ocean wave energy harvesters for moored or unmoored buoys

    NASA Astrophysics Data System (ADS)

    Murray, R.; Rastegar, J.

    2009-03-01

    Harvesting mechanical energy from ocean wave oscillations for conversion to electrical energy has long been pursued as an alternative or self-contained power source. The attraction to harvesting energy from ocean waves stems from the sheer power of the wave motion, which can easily exceed 50 kW per meter of wave front. The principal barrier to harvesting this power is the very low and varying frequency of ocean waves, which generally vary from 0.1Hz to 0.5Hz. In this paper the application of a novel class of two-stage electrical energy generators to buoyant structures is presented. The generators use the buoy's interaction with the ocean waves as a low-speed input to a primary system, which, in turn, successively excites an array of vibratory elements (secondary system) into resonance - like a musician strumming a guitar. The key advantage of the present system is that by having two decoupled systems, the low frequency and highly varying buoy motion is converted into constant and much higher frequency mechanical vibrations. Electrical energy may then be harvested from the vibrating elements of the secondary system with high efficiency using piezoelectric elements. The operating principles of the novel two-stage technique are presented, including analytical formulations describing the transfer of energy between the two systems. Also, prototypical design examples are offered, as well as an in-depth computer simulation of a prototypical heaving-based wave energy harvester which generates electrical energy from the up-and-down motion of a buoy riding on the ocean's surface.

  19. Anti-kindling Induced by Two-Stage Coordinated Reset Stimulation with Weak Onset Intensity

    PubMed Central

    Zeitler, Magteld; Tass, Peter A.

    2016-01-01

    Abnormal neuronal synchrony plays an important role in a number of brain diseases. To specifically counteract abnormal neuronal synchrony by desynchronization, Coordinated Reset (CR) stimulation, a spatiotemporally patterned stimulation technique, was designed with computational means. In neuronal networks with spike timing–dependent plasticity CR stimulation causes a decrease of synaptic weights and finally anti-kindling, i.e., unlearning of abnormally strong synaptic connectivity and abnormal neuronal synchrony. Long-lasting desynchronizing aftereffects of CR stimulation have been verified in pre-clinical and clinical proof of concept studies. In general, for different neuromodulation approaches, both invasive and non-invasive, it is desirable to enable effective stimulation at reduced stimulation intensities, thereby avoiding side effects. For the first time, we here present a two-stage CR stimulation protocol, where two qualitatively different types of CR stimulation are delivered one after another, and the first stage comes at a particularly weak stimulation intensity. Numerical simulations show that a two-stage CR stimulation can induce the same degree of anti-kindling as a single-stage CR stimulation with intermediate stimulation intensity. This stimulation approach might be clinically beneficial in patients suffering from brain diseases characterized by abnormal neuronal synchrony where a first treatment stage should be performed at particularly weak stimulation intensities in order to avoid side effects. This might, e.g., be relevant in the context of acoustic CR stimulation in tinnitus patients with hyperacusis or in the case of electrical deep brain CR stimulation with sub-optimally positioned leads or side effects caused by stimulation of the target itself. We discuss how to apply our method in first in man and proof of concept studies. PMID:27242500

  20. Two-stage PCR assay for detection of human brucellosis in endemic areas

    PubMed Central

    2013-01-01

    Background Brucellosis is a common zoonosis that can cause a severe febrile illness in humans. It constitutes a persistent health problem in many developing countries around the world. It is one of the most frequently reported diseases in Saudi Arabia and incidence is particularly high in the Central region, and around the city of Riyadh. The aim of this study was to evaluate a two-stage PCR assay for detection of human brucellosis particularly in endemic areas. Methods A total of 101 serum samples were collected from patients with acute febrile illness (AFI) of unknown cause from two different locations in the Western region of Saudi Arabia. The first location (Northern) is characterized by a nomadic rural population while the second (Central) is a modern urban city. All samples were subjected to DNA extraction and Brucella genus-specific PCR amplification using B4/B5 primers of the bcsp31 gene. Positive B4/B5 samples were subjected to multiplex species-specific Brucella PCR amplification. Results In the Northern location, 81.9% of the AFI samples were confirmed Brucella positive, while all the samples collected from the Central region proved to be Brucella negative. Samples positive for Brucella were subjected to multiplex species-specific Brucella amplification. B. abortus was detected in 10% and B. melitensis in 8% of the samples, while the majority (82%) of samples showed both B. abortus and B. melitensis. As expected, B. suis was not detected in any of the samples. Conclusions This study concluded that a two-stage PCR assay could be useful as a rapid diagnostic tool to allow the consideration of brucellosis as a possible cause of AFI, particularly in non-urban locations. It also recommends the collection of epidemiological data for such patients to obtain further information that may help in rapid diagnosis. PMID:23517532

  1. Enhanced bio-energy recovery in a two-stage hydrogen/methane fermentation process.

    PubMed

    Lee, M J; Song, J H; Hwang, S J

    2009-01-01

    A two-stage hydrogen/methane fermentation process has emerged as a feasible engineering system to recover bio-energy from wastewater. Hydrogen-producing bacteria (HPB) generate hydrogen from readily available carbohydrates, and organic acids produced during the hydrogen fermentation step can be degraded to generate methane in the following step. Three strong acids, HCl, H(2)SO(4), and HNO(3), were tested to determine the appropriate pre-treatment method for enhanced hydrogen production. The hydrogen production rates of 230, 290, and 20 L/kg(-glucose)/day was observed for the sludge treated with HCl, H(2)SO(4), and HNO(3), respectively, indicating that the acid pre-treatment using either HCl or H(2)SO(4) resulted in a significant increase in hydrogen production. The fluorescent in situ hybridization method indicated that the acid pre-treatment selectively enriched HPB including Clostridium sp. of cluster I from inoculum sludge. After hydrogen fermentation was terminated, the sludge was introduced to a methane fermentation reactor. This experiment showed methane production rates of 100, 30, and 13 L/kg(-glucose)/day for the sludge pre-treated with HCl, H(2)SO(4), and HNO(3), respectively, implying that both sulfate and nitrate inhibited the activity of methane-producing bacteria. Consequently, the acid pre-treatment might be a feasible option to enhance biogas recovery in the two-stage fermentation process, and HCl was selected as the optimal strong acid for the enrichment of HPB and the continuous production of methane.

  2. Focused Ultrasound Simultaneous Irradiation/MRI Imaging, and Two-Stage General Kinetic Model

    PubMed Central

    Huang, Sheng-Yao; Ko, Chia-En; Chen, Gin-Shin; Chung, I-Fang; Yang, Feng-Yi

    2014-01-01

    Many studies have investigated how to use focused ultrasound (FUS) to temporarily disrupt the blood-brain barrier (BBB) in order to facilitate the delivery of medication into lesion sites in the brain. In this study, through the setup of a real-time system, FUS irradiation and injections of ultrasound contrast agent (UCA) and Gadodiamide (Gd, an MRI contrast agent) can be conducted simultaneously during MRI scanning. By using this real-time system, we were able to investigate in detail how the general kinetic model (GKM) is used to estimate Gd penetration in the FUS irradiated area in a rat's brain resulting from UCA concentration changes after single FUS irradiation. Two-stage GKM was proposed to estimate the Gd penetration in the FUS irradiated area in a rat's brain under experimental conditions with repeated FUS irradiation combined with different UCA concentrations. The results showed that the focal increase in the transfer rate constant of Ktrans caused by BBB disruption was dependent on the doses of UCA. Moreover, the amount of in vivo penetration of Evans blue in the FUS irradiated area in a rat's brain under various FUS irradiation experimental conditions was assessed to show the positive correlation with the transfer rate constants. Compared to the GKM method, the Two-stage GKM is more suitable for estimating the transfer rate constants of the brain treated with repeated FUS irradiations. This study demonstrated that the entire process of BBB disrupted by FUS could be quantitatively monitored by real-time dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). PMID:24949997

  3. Two-Stage Latissimus Dorsi Flap with Implant for Unilateral Breast Reconstruction: Getting the Size Right

    PubMed Central

    Feng, Jiajun; Pardoe, Cleone I; Mota, Ashley Manuel; Chui, Christopher Hoe Kong

    2016-01-01

    Background The aim of unilateral breast reconstruction after mastectomy is to craft a natural-looking breast with symmetry. The latissimus dorsi (LD) flap with implant is an established technique for this purpose. However, it is challenging to obtain adequate volume and satisfactory aesthetic results using a one-stage operation when considering factors such as muscle atrophy, wound dehiscence and excessive scarring. The two-stage reconstruction addresses these difficulties by using a tissue expander to gradually enlarge the skin pocket which eventually holds an appropriately sized implant. Methods We analyzed nine patients who underwent unilateral two-stage LD reconstruction. In the first stage, an expander was placed along with the LD flap to reconstruct the mastectomy defect, followed by gradual tissue expansion to achieve overexpansion of the skin pocket. The final implant volume was determined by measuring the residual expander volume after aspirating the excess saline. Finally, the expander was replaced with the chosen implant. Results The average volume of tissue expansion was 460 mL. The resultant expansion allowed an implant ranging in volume from 255 to 420 mL to be placed alongside the LD muscle. Seven patients scored less than six on the relative breast retraction assessment formula for breast symmetry, indicating excellent breast symmetry. The remaining two patients scored between six and eight, indicating good symmetry. Conclusions This approach allows the size of the eventual implant to be estimated after the skin pocket has healed completely and the LD muscle has undergone natural atrophy. Optimal reconstruction results were achieved using this approach. PMID:27018318

  4. Reduction of NO{sub x} formation by water sprays in strained two-stage flames

    SciTech Connect

    Li, S.C.; Ilincic, N.; Williams, F.A.

    1997-10-01

    Staged combustion can be employed to reduce the formation of CO and NO{sub x}, stabilize the flame, decrease the flame temperature, and create better working conditions in gas turbine combustors. To help understand influences of partial premixing and addition of water on NO{sub x} formation, the authors study two-stage flames in a counterflow spray burner. This paper reports experimental and theoretical results concerning two-stage combustion in which one feed stream is composed of a fuel-rich mixture of methane and air and the other is air. Water sprays are added to the air stream. This two-phase laminar counterflow configuration exhibits a green premixed flame, a blue diffusion flame, and a vaporization plane. All three are flat and parallel. The separation distances between them decrease with increasing equivalence ratio and strain rate. Flow visualization is provided through illumination by an argon ion laser sheet, velocity fields and spray structure are measured by a phase-doppler particle analyzer, concentration fields of major stable species are measured by gas chromatography of samples withdrawn from the flame, and temperature fields are measured by a thermocouple. Numerical integrations that employ a recent chemical-kinetic data base are performed to model the flame structure and NO{sub x} formation. Comparisons of experimental results with numerical predictions are made to test agreement. This work provides information on hydrocarbon combustion in both premixed flames and diffusion flames, indicates how NO{sub x} is formed in fuel-rich flames, and suggests how the pollutants can be reduced.

  5. Performance evaluation of two-stage fuel cycle from SFR to PWR

    SciTech Connect

    Fei, T.; Hoffman, E.A.; Kim, T.K.; Taiwo, T.A.

    2013-07-01

    One potential fuel cycle option being considered is a two-stage fuel cycle system involving the continuous recycle of transuranics in a fast reactor and the use of bred plutonium in a thermal reactor. The first stage is a Sodium-cooled Fast Reactor (SFR) fuel cycle with metallic U-TRU-Zr fuel. The SFRs need to have a breeding ratio greater than 1.0 in order to produce fissile material for use in the second stage. The second stage is a PWR fuel cycle with uranium and plutonium mixed oxide fuel based on the design and performance of the current state-of-the-art commercial PWRs with an average discharge burnup of 50 MWd/kgHM. This paper evaluates the possibility of this fuel cycle option and discusses its fuel cycle performance characteristics. The study focuses on an equilibrium stage of the fuel cycle. Results indicate that, in order to avoid a positive coolant void reactivity feedback in the stage-2 PWR, the reactor requires high quality of plutonium from the first stage and minor actinides in the discharge fuel of the PWR needs to be separated and sent back to the stage-1 SFR. The electricity-sharing ratio between the 2 stages is 87.0% (SFR) to 13.0% (PWR) for a TRU inventory ratio (the mass of TRU in the discharge fuel divided by the mass of TRU in the fresh fuel) of 1.06. A sensitivity study indicated that by increasing the TRU inventory ratio to 1.13, The electricity generation fraction of stage-2 PWR is increased to 28.9%. The two-stage fuel cycle system considered in this study was found to provide a high uranium utilization (>80%). (authors)

  6. [High resolution laser transient spectroscopic technology under two-stage light gas-gun loading condition and stability study of shocked benzene].

    PubMed

    Zhao, Bei-Jing; Liu, Fu-Sheng; Wang, Wen-Peng; Zhang, Ning-Chao; Feng, Li-Peng; Zhang, Ming-Jian; Xue, Xue-Dong

    2013-10-01

    The present paper reports the high resolution transient Raman laser testing technology under two-stage light gas-gun loading experiment, and its application to studying the Raman spectroscopy of shocked benzene. In the experiments, the frequency shift of C-C stretching vibration (992 cm(-1)) and C-H stretching vibration peak (3 061 cm(-1)) in the low pressure section (less than 8 GPa) varies linearly with the pressure, and the results agree well with reported data in the literature. The structural changes in liquid benzene about 13 GPa were clarified firstly by the Raman spectral technique; the experimental results show that at a pressure of 9.7 GPa, the structural change of liquid benzene has taken place, not reported in the literature about 13 GPa. But the composition in the production is not clear. The measurement system provides an effective means to study the microstructure changes of transparent and translucent material under dynamic loading experiment.

  7. A PRIOR EVALUATION OF TWO-STAGE CLUSTER SAMPLING FOR ACCURACY ASSESSMENT OF LARGE-AREA LAND-COVER MAPS

    EPA Science Inventory

    Two-stage cluster sampling reduces the cost of collecting accuracy assessment reference data by constraining sample elements to fall within a limited number of geographic domains (clusters). However, because classification error is typically positively spatially correlated, withi...

  8. Pressurized Testing of Solid Oxide Electrolysis Stacks with Advanced Electrode-Supported Cells

    SciTech Connect

    J. E. O'Brien; X. Zhang; G. K. Housley; K. DeWall; L. Moore-McAteer; G. Tao

    2012-06-01

    A new facility has been developed at the Idaho National Laboratory for pressurized testing of solid oxide electrolysis stacks. Pressurized operation is envisioned for large-scale hydrogen production plants, yielding higher overall efficiencies when the hydrogen product is to be delivered at elevated pressure for tank storage or pipelines. Pressurized operation also supports higher mass flow rates of the process gases with smaller components. The test stand can accommodate cell dimensions up to 8.5 cm x 8.5 cm and stacks of up to 25 cells. The pressure boundary for these tests is a water-cooled spool-piece pressure vessel designed for operation up to 5 MPa. The stack is internally manifolded and operates in cross-flow with an inverted-U flow pattern. Feed-throughs for gas inlets/outlets, power, and instrumentation are all located in the bottom flange. The entire spool piece, with the exception of the bottom flange, can be lifted to allow access to the internal furnace and test fixture. Lifting is accomplished with a motorized threaded drive mechanism attached to a rigid structural frame. Stack mechanical compression is accomplished using springs that are located inside of the pressure boundary, but outside of the hot zone. Initial stack heatup and performance characterization occurs at ambient pressure followed by lowering and sealing of the pressure vessel and subsequent pressurization. Pressure equalization between the anode and cathode sides of the cells and the stack surroundings is ensured by combining all of the process gases downstream of the stack. Steady pressure is maintained by means of a backpressure regulator and a digital pressure controller. A full description of the pressurized test apparatus is provided in this paper.

  9. Advanced Production Surface Preparation Technology Development for Ultra-High Pressure Diesel Injection

    SciTech Connect

    Grant, Marion B.

    2012-04-30

    In 2007, An Ultra High Injection Pressure (UHIP) fueling method has been demonstrated by Caterpillar Fuel Systems - Product Development, demonstrating ability to deliver U.S. Environment Protection Agency (EPA) Tier 4 Final diesel engine emission performance with greatly reduced emissions handling components on the engine, such as without NOx reduction after-treatment and with only a through-flow 50% effective diesel particulate trap (DPT). They have shown this capability using multiple multi-cylinder engine tests of an Ultra High Pressure Common Rail (UHPCR) fuel system with higher than traditional levels of CEGR and an advanced injector nozzle design. The system delivered better atomization of the fuel, for more complete burn, to greatly reduce diesel particulates, while CEGR or high efficiency NOx reduction after-treatment handles the NOx. With the reduced back pressure of a traditional DPT, and with the more complete fuel burn, the system reduced levels of fuel consumption by 2.4% for similar delivery of torque and horsepower over the best Tier 4 Interim levels of fuel consumption in the diesel power industry. The challenge is to manufacture the components in high-volume production that can withstand the required higher pressure injection. Production processes must be developed to increase the toughness of the injector steel to withstand the UHIP pulsations and generate near perfect form and finish in the sub-millimeter size geometries within the injector. This project resulted in two developments in 2011. The first development was a process and a machine specification by which a high target of compressive residual stress (CRS) can be consistently imparted to key surfaces of the fuel system to increase the toughness of the steel, and a demonstration of the feasibility of further refinement of the process for use in volume production. The second development was the demonstration of the feasibility of a process for imparting near perfect, durable geometry to

  10. New Two-stage Approach For 3d Potential Field Data Inversion

    NASA Astrophysics Data System (ADS)

    Prutkin, I. L.

    From the author's viewpoint the main challenges for a geophysicist dealing with po- tential field data inversion are following: 1) to make really three-dimensional inversion (to avoid the assumption that the object sought is an infinite cylinder); 2) to leave the simplest bodies (prisms, ellipsoids, cylinders of finite length) for the objects of more complex geometry, 3) to take into account the non-uniqueness of the inverse problem. In our investigation we've made an attempt to solve the above-mentioned problems. We take into account the non- uniqueness of the inverse problem in the framework of the equivalence theory developed by A.V. Tsyrulsky. We have reduced 3D grav- ity and magnetic inverse problems to the non-linear integral equations of the 1st kind relative to the function determining geometry of the object sought. They include a physical parameter as a numerical factor. Substituting different values of it, we obtain the opportunity to construct the whole equivalent family of the solutions. New inte- gral equations have been derived, which integrands are algebraic relative the function sought and don't contain its derivatives. The method of local corrections has been suggested, which makes it possible to curtail the time required to solve an inverse problem approximately by an order of magnitude. The parameterization of the solu- tion sought and regularization of an inverse problem were studied. On the base of his equivalence theory A.V. Tsyrulsky had suggested two-stage approach for 2D gravity and magnetic anomalies interpretation. The aim of the first stage is to approximate the observed field by the field of a sum of the simplest sources (point sources, thin layers, etc.) of no geological sense. On the second stage the field of a sum of some sources is regarded as a field of the object sought, we are able to try different variants to unite sources and to construct the equivalent family of solutions. Sole member of the family should be chosen with taking

  11. Two-Stage Automatic Calibration and Predictive Uncertainty Analysis of a Semi-distributed Watershed Model

    NASA Astrophysics Data System (ADS)

    Lin, Z.; Radcliffe, D. E.; Doherty, J.

    2004-12-01

    Automatic calibration has been applied to conceptual rainfall-runoff models for more than three decades, usually to lumped models. Even when a (semi-)distributed model that allows spatial variability of parameters is calibrated using an automated process, the parameters of the model are often lumped over space so that the model is simplified as a lumped model. Our objective was to develop a two-stage routine for automatically calibrating the Soil Water Assessment Tool (SWAT, a semi-distributed watershed model) that would find the optimal values for the model parameters, preserve the spatial variability in essential parameters, and lead to a measure of the model prediction uncertainty. In the first stage of this proposed calibration scheme, a global search method, namely, the Shuffled Complex Evolution (SCE-UA) method, was employed to find the ``best'' values for the lumped model parameters. That is, in order to limit the number of the calibrated parameters, the model parameters were assumed to be invariant over different subbasins and hydrologic response units (HRU, the basic calculation unit in the SWAT model). However, in the second stage, the spatial variability of the original model parameters was restored and the number of the calibrated parameters was dramatically increased (from a few to near a hundred). Hence, a local search method, namely, a variation of Levenberg-Marquart method, was preferred to find the more distributed set of parameters using the results of the previous stage as starting values. Furthermore, in order to prevent the parameters from taking extreme values, a strategy called ``regularization'' was adopted, through which the distributed parameters were constrained to vary as little as possible from the initial values of the lumped parameters. We calibrated the stream flow in the Etowah River measured at Canton, GA (a watershed area of 1,580 km2) for the years 1983-1992 and used the years 1993-2001 for validation. Calibration for daily and

  12. Reducing the risk of foaming and decreasing viscosity by two-stage anaerobic digestion of sugar beet pressed pulp.

    PubMed

    Stoyanova, Elitza; Forsthuber, Boris; Pohn, Stefan; Schwarz, Christian; Fuchs, Werner; Bochmann, Günther

    2014-04-01

    Anaerobic digestion (AD) of sugar beet pressed pulp (SBPP) is a promising treatment concept. It produces biogas as a renewable energy source making sugar production more energy efficient and it turns SBPP from a residue into a valuable resource. In this study one- and two-stage mono fermentation at mesophilic conditions in a continuous stirred tank reactor were compared. Also the optimal incubation temperature for the pre-acidification stage was studied. The fastest pre-acidification, with a hydraulic retention time (HRT) of 4 days, occurred at a temperature of 55 °C. In the methanogenic reactor of the two-stage system stable fermentation at loading rate of 7 kg VS/m³ d was demonstrated. No artificial pH adjustment was necessary to maintain optimum levels in both the pre-acidification and the methanogenic reactor. The total HRT of the two-stage AD was 36 days which is considerably lower compared to the one-stage AD (50 days). The frequently observed problem of foaming at high loading rates was less severe in the two-stage reactor. Moreover the viscosity of digestate in the methanogenic stage of the two-stage fermentation was in average tenfold lower than in the one-stage fermentation. This decreases the energy input for the reactor stirring about 80 %. The observed advantages make the two-stage process economically attractive, despite higher investments for a two reactor system.

  13. Design and Characterization of Thin Stainless Steel Burst Disks for Increasing Two-Stage Light Gas Launcher Efficiency

    NASA Technical Reports Server (NTRS)

    Tylka, Jonathan M.; Johnson, Kenneth L.; Henderson, Donald; Rodriguez, Karen

    2012-01-01

    Laser etched 300 series Stainless Steel Burst Disks (SSBD) ranging between 0.178 mm (0.007-in.) and 0.508mm (0.020-in.) thick were designed for use in a 17-caliber two-stage light gas launcher. First, a disk manufacturing method was selected using a combination of wire electrical discharge machining (EDM) to form the blank disks and laser etching to define the pedaling fracture pattern. Second, a replaceable insert was designed to go between the SSDB and the barrel. This insert reduced the stress concentration between the SSBD and the barrel, providing a place for the petals of the SSDB to open, and protecting the rifling on the inside of the barrel. Thereafter, a design of experiments was implemented to test and characterize the burst characteristics of SSBDs. Extensive hydrostatic burst testing of the SSBDs was performed to complete the design of experiments study with one-hundred and seven burst tests. The experiment simultaneously tested the effects of the following: two SSBD material states (full hard, annealed); five SSBD thicknesses 0.178, 0.254, 0.305, 0.381 mm (0.007, 0.010, 0.012, 0.015, 0.020-in.); two grain directions relative); number of times the laser etch pattern was repeated (varies between 5-200 times); two heat sink configurations (with and without heat sink); and, two barrel configurations (with and without insert). These tests resulted in the quantification of the relationship between SSBD thickness, laser etch parameters, and desired burst pressure. Of the factors investigated only thickness and number of laser etches were needed to develop a mathematical relationship predicting hydrostatic burst pressure of disks using the same barrel configuration. The fracture surfaces of two representative SSBD bursts were then investigated with a scanning electron microscope, one burst hydrostatically in a fixture and another dynamically in the launcher. The fracture analysis verified that both burst conditions resulted in a ductile overload failure

  14. Cost-utility analysis of an advanced pressure ulcer management protocol followed by trained wound, ostomy, and continence nurses.

    PubMed

    Kaitani, Toshiko; Nakagami, Gojiro; Iizaka, Shinji; Fukuda, Takashi; Oe, Makoto; Igarashi, Ataru; Mori, Taketoshi; Takemura, Yukie; Mizokami, Yuko; Sugama, Junko; Sanada, Hiromi

    2015-01-01

    The high prevalence of severe pressure ulcers (PUs) is an important issue that requires to be highlighted in Japan. In a previous study, we devised an advanced PU management protocol to enable early detection of and intervention for deep tissue injury and critical colonization. This protocol was effective for preventing more severe PUs. The present study aimed to compare the cost-effectiveness of the care provided using an advanced PU management protocol, from a medical provider's perspective, implemented by trained wound, ostomy, and continence nurses (WOCNs), with that of conventional care provided by a control group of WOCNs. A Markov model was constructed for a 1-year time horizon to determine the incremental cost-effectiveness ratio of advanced PU management compared with conventional care. The number of quality-adjusted life-years gained, and the cost in Japanese yen (¥) ($US1 = ¥120; 2015) was used as the outcome. Model inputs for clinical probabilities and related costs were based on our previous clinical trial results. Univariate sensitivity analyses were performed. Furthermore, a Bayesian multivariate probability sensitivity analysis was performed using Monte Carlo simulations with advanced PU management. Two different models were created for initial cohort distribution. For both models, the expected effectiveness for the intervention group using advanced PU management techniques was high, with a low expected cost value. The sensitivity analyses suggested that the results were robust. Intervention by WOCNs using advanced PU management techniques was more effective and cost-effective than conventional care.

  15. Antioxidant enzyme changes in neem, pigeonpea and mulberry leaves in two stages of maturity

    PubMed Central

    Goud, Prashanth B.; Kachole, Manvendra S.

    2012-01-01

    Differential expression of antioxidant enzymes in various growth and differentiation stages has been documented in several plant species. We studied here, the difference in the levels of protein content and antioxidant enzymes activity at two stages of maturity, named young and mature in neem (Azadirachta indica A. Juss), pigeonpea (Cajanus cajan (L.) mill sp) and mulberry (Morus Alba L.) leaves. The results showed that detached neem and pigeonpea mature leaves possessed higher activities of catalase (CAT) and peroxidase (POD) and lower activities of polyphenol oxidase (PPO) and ascorbate peroxidase (APX) as compared with young leaves. However, glutathione reductase (GR) showed higher activity in mature leaves of neem, whereas no change in its activity was observed in pigeonpea. On the other hand, antioxidant enzymes in mulberry showed either positive (PPO) or negative (POD, GR, APX) correlation with the progression of leaf maturity. Apparently the trend of changes in antioxidant enzymes activity during leaf development is species-specific: their activity higher at mature stage in some plants and lower in others. PMID:22895104

  16. Two-stage dose finding for cytostatic agents in phase I oncology trials.

    PubMed

    Yin, Guosheng; Zheng, Shurong; Xu, Jiajing

    2013-02-20

    Conventional dose-finding methods in oncology are mainly developed for cytotoxic agents with the aim of finding the maximum tolerated dose. In phase I clinical trials with cytostatic agents, such as targeted therapies, designs with toxicity endpoints alone may not work well. For cytostatic agents, the goal is often to find the most efficacious dose that is still tolerable, although these agents are typically less toxic than cytotoxic agents and their efficacy may not monotonically increase with the dose. To effectively differentiate doses for cytostatic agents, we develop a two-stage dose-finding procedure by first identifying the toxicity upper bound of the searching range through dose escalation and then determining the most efficacious dose through dose de-escalation while toxicity is continuously monitored. In oncology, treatment efficacy often takes a relatively long period to exhibit compared with toxicity. To accommodate such delayed response, we model the time to the efficacy event by redistributing the mass of the censored observation to the right and compute the fractional contribution of the censored data. We evaluate the operating characteristics of the new dose-finding design for cytostatic agents and demonstrate its satisfactory performance through simulation studies.

  17. Hypervelocity projectile acceleration with a railgun using a two-stage gas gun injector

    NASA Astrophysics Data System (ADS)

    Hawke, R. S.

    1989-04-01

    Unique potential applications of electromagnetic railguns [R.S. Hawke, IEEE Trans. Nucl. NS-28 (2) (1981) 1542] have motivated a decade of continuous development throughout the world. This effort has led to routine acceleration of projectiles of from 1 g to about 1 kg, to velocities of nearly 4 km/s. Attempts to reach higher velocities have met with problems in the 6- to 8-km/s range [J.V. Parker, Proc. 4th Symp. on Electromagnetic Launch Tech., Austin, TX, 1988, to be published in IEEE Trans. Mag.]. The principal problem is "restrike", which causes shunting of the propulsive plasma armature by the formation of a second plasma short circuit in the breech region of the railgun. One means of impeding restrike is the use of a two-stage light-gas gun (2SLGG) as a projectile injector. A joint development project was initiated in early 1986 between the Sandia National Laboratories Albuquerque (SNLA) and the Lawrence Livermore National Laboratory (LLNL). The project is based on the use of a 2SLGG to inject projectiles at about 7 km/s. The injection gas is hydrogen, which serves to inhibit formation of the secondary arc and to minimize barrel ablation and armature contamination. Results and status of this work are discussed.

  18. A Two-Stage-to-Orbit Spaceplane Concept With Growth Potential

    NASA Technical Reports Server (NTRS)

    Mehta, Unmeel B.; Bowles, Jeffrey V.

    2001-01-01

    A two-stage-to-orbit (TSTO) spaceplane concept developed in 1993 is revisited, and new information is provided to assist in the development of the next-generation space transportation vehicles. The design philosophy, TSTO spaceplane concept, and the design method are briefly described. A trade study between cold and hot structures leads to the choice of cold structures with external thermal protection systems. The optimal Mach number for staging the second stage of the TSTO spaceplane (with air-breathing propulsion on the first stage) is 10, based on life-cycle cost analysis. The performance and specification of a prototype/experimental (P/X) TSTO spaceplane with a turbo/ram/scramjet propulsion system and built-in growth potential are presented and discussed. The internal rate of return on investment is the highest for the proposed TSTO spaceplane, vis-A-vis a single-stage-to-orbit (SSTO) rocket vehicle and a TSTO spaceplane without built-in growth. Additional growth potentials for the proposed spaceplane are suggested. This spaceplane can substantially decrease access-to-space cost and risk, and increase safety and reliability in the near term It can be a serious candidate for the next-generation space transportation system.

  19. A Two-Stage Procedure Toward the Efficient Implementation of PANS and Other Hybrid Turbulence Models

    NASA Technical Reports Server (NTRS)

    Abdol-Hamid, Khaled S.; Girimaji, Sharath S.

    2004-01-01

    The main objective of this article is to introduce and to show the implementation of a novel two-stage procedure to efficiently estimate the level of scale resolution possible for a given flow on a given grid for Partial Averaged Navier-Stokes (PANS) and other hybrid models. It has been found that the prescribed scale resolution can play a major role in obtaining accurate flow solutions. The first step is to solve the unsteady or steady Reynolds Averaged Navier-Stokes (URANS/RANS) equations. From this preprocessing step, the turbulence length-scale field is obtained. This is then used to compute the characteristic length-scale ratio between the turbulence scale and the grid spacing. Based on this ratio, we can assess the finest scale resolution that a given grid for a given flow can support. Along with other additional criteria, we are able to analytically identify the appropriate hybrid solver resolution for different regions of the flow. This procedure removes the grid dependency issue that affects the results produced by different hybrid procedures in solving unsteady flows. The formulation, implementation methodology, and validation example are presented. We implemented this capability in a production Computational Fluid Dynamics (CFD) code, PAB3D, for the simulation of unsteady flows.

  20. Simulation and Analyses of Stage Separation of Two-Stage Reusable Launch Vehicles

    NASA Technical Reports Server (NTRS)

    Pamadi, Bandu N.; Neirynck, Thomas A.; Hotchko, Nathaniel J.; Tartabini, Paul V.; Scallion, William I.; Murphy, K. J.; Covell, Peter F.

    2007-01-01

    NASA has initiated the development of methodologies, techniques and tools needed for analysis and simulation of stage separation of next generation reusable launch vehicles. As a part of this activity, ConSep simulation tool is being developed which is a MATLAB-based front-and-back-end to the commercially available ADAMS(Registerd TradeMark) solver, an industry standard package for solving multi-body dynamic problems. This paper discusses the application of ConSep to the simulation and analysis of staging maneuvers of two-stage-to-orbit (TSTO) Bimese reusable launch vehicles, one staging at Mach 3 and the other at Mach 6. The proximity and isolated aerodynamic database were assembled using the data from wind tunnel tests conducted at NASA Langley Research Center. The effects of parametric variations in mass, inertia, flight path angle, altitude from their nominal values at staging were evaluated. Monte Carlo runs were performed for Mach 3 staging to evaluate the sensitivity to uncertainties in aerodynamic coefficients.

  1. Comparing regression methods for the two-stage clonal expansion model of carcinogenesis.

    PubMed

    Kaiser, J C; Heidenreich, W F

    2004-11-15

    In the statistical analysis of cohort data with risk estimation models, both Poisson and individual likelihood regressions are widely used methods of parameter estimation. In this paper, their performance has been tested with the biologically motivated two-stage clonal expansion (TSCE) model of carcinogenesis. To exclude inevitable uncertainties of existing data, cohorts with simple individual exposure history have been created by Monte Carlo simulation. To generate some similar properties of atomic bomb survivors and radon-exposed mine workers, both acute and protracted exposure patterns have been generated. Then the capacity of the two regression methods has been compared to retrieve a priori known model parameters from the simulated cohort data. For simple models with smooth hazard functions, the parameter estimates from both methods come close to their true values. However, for models with strongly discontinuous functions which are generated by the cell mutation process of transformation, the Poisson regression method fails to produce reliable estimates. This behaviour is explained by the construction of class averages during data stratification. Thereby, some indispensable information on the individual exposure history was destroyed. It could not be repaired by countermeasures such as the refinement of Poisson classes or a more adequate choice of Poisson groups. Although this choice might still exist we were unable to discover it. In contrast to this, the individual likelihood regression technique was found to work reliably for all considered versions of the TSCE model. PMID:15490436

  2. Non-ideal magnetohydrodynamic simulations of the two-stage fragmentation model for cluster formation

    SciTech Connect

    Bailey, Nicole D.; Basu, Shantanu E-mail: basu@uwo.ca

    2014-01-01

    We model molecular cloud fragmentation with thin-disk, non-ideal magnetohydrodynamic simulations that include ambipolar diffusion and partial ionization that transitions from primarily ultraviolet-dominated to cosmic-ray-dominated regimes. These simulations are used to determine the conditions required for star clusters to form through a two-stage fragmentation scenario. Recent linear analyses have shown that the fragmentation length scales and timescales can undergo a dramatic drop across the column density boundary that separates the ultraviolet- and cosmic-ray-dominated ionization regimes. As found in earlier studies, the absence of an ionization drop and regular perturbations leads to a single-stage fragmentation on pc scales in transcritical clouds, so that the nonlinear evolution yields the same fragment sizes as predicted by linear theory. However, we find that a combination of initial transcritical mass-to-flux ratio, evolution through a column density regime in which the ionization drop takes place, and regular small perturbations to the mass-to-flux ratio is sufficient to cause a second stage of fragmentation during the nonlinear evolution. Cores of size ∼0.1 pc are formed within an initial fragment of ∼pc size. Regular perturbations to the mass-to-flux ratio also accelerate the onset of runaway collapse.

  3. Two-stage screening for math problem-solving difficulty using dynamic assessment of algebraic learning.

    PubMed

    Fuchs, Lynn S; Compton, Donald L; Fuchs, Douglas; Hollenbeck, Kurstin N; Hamlett, Carol L; Seethaler, Pamela M

    2011-01-01

    The purpose of this study was to explore the utility of a dynamic assessment (DA) of algebraic learning in predicting third graders' development of mathematics word-problem difficulty. In the fall, 122 third-grade students were assessed on a test of math word-problem skill and DA of algebraic learning. In the spring, they were assessed on word-problem performance. Logistic regression was conducted to contrast two models. One relied exclusively on the fall test of math word-problem skill to predict word-problem difficulty on the spring outcome (less than the 25th percentile). The second model relied on a combination of the fall test of math word-problem skill and the fall DA to predict the same outcome. Holding sensitivity at 87.5%, the universal screener alone resulted in a high proportion of false positives, which was practically reduced when DA was included in the prediction model. Findings are discussed in terms of a two-stage process for screening students within a responsiveness-to-intervention prevention model.

  4. Two-Stage Path Planning Approach for Designing Multiple Spacecraft Reconfiguration Maneuvers

    NASA Technical Reports Server (NTRS)

    Aoude, Georges S.; How, Jonathan P.; Garcia, Ian M.

    2007-01-01

    The paper presents a two-stage approach for designing optimal reconfiguration maneuvers for multiple spacecraft. These maneuvers involve well-coordinated and highly-coupled motions of the entire fleet of spacecraft while satisfying an arbitrary number of constraints. This problem is particularly difficult because of the nonlinearity of the attitude dynamics, the non-convexity of some of the constraints, and the coupling between the positions and attitudes of all spacecraft. As a result, the trajectory design must be solved as a single 6N DOF problem instead of N separate 6 DOF problems. The first stage of the solution approach quickly provides a feasible initial solution by solving a simplified version without differential constraints using a bi-directional Rapidly-exploring Random Tree (RRT) planner. A transition algorithm then augments this guess with feasible dynamics that are propagated from the beginning to the end of the trajectory. The resulting output is a feasible initial guess to the complete optimal control problem that is discretized in the second stage using a Gauss pseudospectral method (GPM) and solved using an off-the-shelf nonlinear solver. This paper also places emphasis on the importance of the initialization step in pseudospectral methods in order to decrease their computation times and enable the solution of a more complex class of problems. Several examples are presented and discussed.

  5. Two-stage sequential sampling: A neighborhood-free adaptive sampling procedure

    USGS Publications Warehouse

    Salehi, M.; Smith, D.R.

    2005-01-01

    Designing an efficient sampling scheme for a rare and clustered population is a challenging area of research. Adaptive cluster sampling, which has been shown to be viable for such a population, is based on sampling a neighborhood of units around a unit that meets a specified condition. However, the edge units produced by sampling neighborhoods have proven to limit the efficiency and applicability of adaptive cluster sampling. We propose a sampling design that is adaptive in the sense that the final sample depends on observed values, but it avoids the use of neighborhoods and the sampling of edge units. Unbiased estimators of population total and its variance are derived using Murthy's estimator. The modified two-stage sampling design is easy to implement and can be applied to a wider range of populations than adaptive cluster sampling. We evaluate the proposed sampling design by simulating sampling of two real biological populations and an artificial population for which the variable of interest took the value either 0 or 1 (e.g., indicating presence and absence of a rare event). We show that the proposed sampling design is more efficient than conventional sampling in nearly all cases. The approach used to derive estimators (Murthy's estimator) opens the door for unbiased estimators to be found for similar sequential sampling designs. ?? 2005 American Statistical Association and the International Biometric Society.

  6. Formation of CuInSSe thin films by conventional two-stage process

    NASA Astrophysics Data System (ADS)

    Shrotriya, Vipin; Rajaram, P.

    2016-05-01

    We have fabricated Crystalline CuInSSe thin films on glass substrate by conventional two-stage process. In first stage CuInS2 thin films have been grown on glass substrate by spray pyrolysis method at constant temperature 320°C. The CuCl2, InCl3, and thiourea were used as source materials for the Cu, In, and S precursors respectively and the Cu/In ratio is kept at 1.0. In second stage the precursor films of CuInS2 are selenized to get CuInSSe. The grown thin films of CuInS2 and CuInSSe were characterized by XRD, SEM and optical studies. The average crystallite size of the CISS thin films is found to be in the range 10-20 nm, using the Scherrer formula. The band gap value of the CuInSSe films is found to be 1.26 eV.

  7. Performance assessment of two-stage anaerobic digestion of kitchen wastes.

    PubMed

    Bo, Zhang; Pin-Jing, He

    2014-01-01

    This study is aimed at investigating the performance of the two-phase anaerobic digestion of kitchen wastes in a lab-scale setup. The semi-continuous experiment showed that the two-phase anaerobic digestion of kitchen wastes had a bioconversion rate of 83%, biogas yield of 338 mL x (g chemical oxygen demand (COD))(-1) and total solid conversion of 63% when the entire two-phase anaerobic digestion process was subjected to an organic loading rate (OLR) of 10.7 g x (L d)(-1). In the hydrolysis-acidogenesis process, the efficiency of solubilization decreased from 72.6% to 41.1%, and the acidogenesis efficiency decreased from 31.8% to 17.8% with an increase in the COD loading rate. On the other hand, the performance of the subsequent methanogenic process was not susceptible to the increase in the feeding COD loading rate in the hydrolysis-acidogenesis stage. Lactic acid was one of the main fermentation products, accounting for over 40% of the total soluble COD in the fermentation liquid. The batch experiments indicated that the lactic acid was the earliest predominant fermentation product, and distributions of fermentation products were pH dependent. Results showed that increasing the feeding OLR of kitchen wastes made the two-stage anaerobic digestion process more effective. Moreover, there was a potential improvement in the performance of anaerobic digestion of kitchen wastes with a corresponding improvement in the hydrolysis process.

  8. An adaptive two-stage energy-efficiency mechanism for the doze mode in EPON

    NASA Astrophysics Data System (ADS)

    Nikoukar, AliAkbar; Hwang, I.-Shyan; Su, Yu-Min; Liem, Andrew Tanny

    2016-07-01

    Sleep and doze power-saving modes are the common ways to reduce power consumption of optical network units (ONUs) in Ethernet passive optical network (EPON). The doze mode turns off the ONU transmitter when there is no traffic in the upstream direction while the sleep mode turns off the ONU transmitter and receiver. As the result, the sleep mode is more efficient compared to the doze mode, but it introduces additional complexity of scheduling and signaling, losses the clock synchronization and requires long clock recovery time; furthermore, it requires the cooperation of the optical line terminal (OLT) in the downstream direction to queue frames. To improve the energy-saving in the doze mode, a new two-stage mechanism is introduced that the doze sleep duration is extended for longer time with acceptable quality-of-services (QoS) metrics when ONU is idle in the current cycle. By this way the ONU enters the doze mode even in the high load traffic; moreover, the green dynamic bandwidth allocation (GBA) is proposed to calculate the doze sleep duration based on the ONU queue state and incoming traffic ratio. Simulation results show that the proposed mechanism significantly improves the energy-saving 74% and 54% when traffic load is from the light load to the high load in different traffic situations, and also promises the QoS performance.

  9. Two-stage method for purification of ceruloplasmin based on its interaction with neomycin.

    PubMed

    Sokolov, A V; Kostevich, V A; Romanico, D N; Zakharova, E T; Vasilyev, V B

    2012-06-01

    A two-stage chromatography that yields highly purified ceruloplasmin (CP) from human plasma and from rat and rabbit serum is described. The isolation procedure is based on the interaction of CP with neomycin, and it provides a high yield of CP. Constants of inhibition by gentamycin, kanamycin, and neomycin of oxidase activity of CP in its reaction with p-phenylenediamine were assayed. The lowest K(i) for neomycin (11 µM) corresponded to the highest specific adsorption of CP on neomycin-agarose (10 mg CP/ml of resin). Isolation of CP from 1.4 liters of human plasma using ion-exchange chromatography on UNO-Sphere Q and affinity chromatography on neomycin-agarose yields 348 mg of CP with 412-fold purification degree. Human CP preparation obtained with A(610)/A(280) ~ 0.052 contained neither immunoreactive prothrombin nor active thrombin. Upon storage at 37°C under sterile conditions, the preparation remained stable for two months. Efficient preparation of highly purified CP from rat and rabbit sera treated according to a similar protocol suggests the suitability of our method for isolation of CP from plasma and serum of other animals. The yield of CP in three separate purifications was no less than 78%.

  10. Two stages of directed forgetting: Electrophysiological evidence from a short-term memory task.

    PubMed

    Gao, Heming; Cao, Bihua; Qi, Mingming; Wang, Jing; Zhang, Qi; Li, Fuhong

    2016-06-01

    In this study, a short-term memory test was used to investigate the temporal course and neural mechanism of directed forgetting under different memory loads. Within each trial, two memory items with high or low load were presented sequentially, followed by a cue indicating whether the presented items should be remembered. After an interval, subjects were asked to respond to the probe stimuli. The ERPs locked to the cues showed that (a) the effect of cue type was initially observed during the P2 (160-240 ms) time window, with more positive ERPs for remembering relative to forgetting cues; (b) load effects were observed during the N2-P3 (250-500 ms) time window, with more positive ERPs for the high-load than low-load condition; (c) the cue effect was also observed during the N2-P3 time window, with more negative ERPs for forgetting versus remembering cues. These results demonstrated that directed forgetting involves two stages: task-relevance identification and information discarding. The cue effects during the N2 epoch supported the view that directed forgetting is an active process. PMID:26892593

  11. Simulation and Analyses of Stage Separation Two-Stage Reusable Launch Vehicles

    NASA Technical Reports Server (NTRS)

    Pamadi, Bandu N.; Neirynck, Thomas A.; Hotchko, Nathaniel J.; Tartabini, Paul V.; Scallion, William I.; Murphy, Kelly J.; Covell, Peter F.

    2005-01-01

    NASA has initiated the development of methodologies, techniques and tools needed for analysis and simulation of stage separation of next generation reusable launch vehicles. As a part of this activity, ConSep simulation tool is being developed which is a MATLAB-based front-and-back-end to the commercially available ADAMS(registered Trademark) solver, an industry standard package for solving multi-body dynamic problems. This paper discusses the application of ConSep to the simulation and analysis of staging maneuvers of two-stage-to-orbit (TSTO) Bimese reusable launch vehicles, one staging at Mach 3 and the other at Mach 6. The proximity and isolated aerodynamic database were assembled using the data from wind tunnel tests conducted at NASA Langley Research Center. The effects of parametric variations in mass, inertia, flight path angle, altitude from their nominal values at staging were evaluated. Monte Carlo runs were performed for Mach 3 staging to evaluate the sensitivity to uncertainties in aerodynamic coefficients.

  12. Estimating the prevalence of multiple diseases from two-stage hierarchical pooling.

    PubMed

    Warasi, Md S; Tebbs, Joshua M; McMahan, Christopher S; Bilder, Christopher R

    2016-09-20

    Testing protocols in large-scale sexually transmitted disease screening applications often involve pooling biospecimens (e.g., blood, urine, and swabs) to lower costs and to increase the number of individuals who can be tested. With the recent development of assays that detect multiple diseases, it is now common to test biospecimen pools for multiple infections simultaneously. Recent work has developed an expectation-maximization algorithm to estimate the prevalence of two infections using a two-stage, Dorfman-type testing algorithm motivated by current screening practices for chlamydia and gonorrhea in the USA. In this article, we have the same goal but instead take a more flexible Bayesian approach. Doing so allows us to incorporate information about assay uncertainty during the testing process, which involves testing both pools and individuals, and also to update information as individuals are tested. Overall, our approach provides reliable inference for disease probabilities and accurately estimates assay sensitivity and specificity even when little or no information is provided in the prior distributions. We illustrate the performance of our estimation methods using simulation and by applying them to chlamydia and gonorrhea data collected in Nebraska. Copyright © 2016 John Wiley & Sons, Ltd. PMID:27090057

  13. Observations of a Two-Stage Solar Eruptive Event (SEE): Evidence for Secondary Heating

    NASA Technical Reports Server (NTRS)

    Su, Yang; Dennis, Brian R.; Holman, Gordon D.; Wang, Tongjiang; Chamberlin, Phillip C.; Savage, Sabrina; Veronig, Astrid

    2012-01-01

    We present RHESSI, SDO/AIA, SOHO/LASCO, STEREO, and GOES observations of a partially occulted solar eruptive event (SEE) that occurred at the South-West limb on 8 March, 2011. The GOES X-ray light curve shows two peaks separated by almost two hours that we interpret as two stages of a single event associated with the delayed eruption of a CME. A hot flux rope formed during the first stage and continued expanding and rising throughout the event. The speed of the flux rope decreased from approx.120 to 14 km/s during the decay phase of the first stage and increased again during the second stage to become the CME with a speed of approx.516 km/s. RHESSI and GOES data analyses show that the plasma temperature reached over 20 MK in the first stage, then decreased to approx.10 MK and increased to 15 MK in the second stage. This event provides clear evidence for a secondary heating phase. The enhanced EUV and X-ray emission came from the high corona ( approx.60 arcsec above the limb) in the second stage, approx.40 arcsec higher than the site of the initial flare emission. STEREO-A on-disk observations indicate that the post-flare loops during this stage were of larger scale sizes and spatially distinct from those in the first stage.

  14. Payload Performance Analysis for a Reusable Two-Stage-to-Orbit Vehicle

    NASA Technical Reports Server (NTRS)

    Tartabini, Paul V.; Beaty, James R.; Lepsch, Roger A.; Gilbert, Michael G.

    2015-01-01

    This paper investigates a unique approach in the development of a reusable launch vehicle where, instead of designing the vehicle to be reusable from its inception, as was done for the Space Shuttle, an expendable two stage launch vehicle is evolved over time into a reusable launch vehicle. To accomplish this objective, each stage is made reusable by adding the systems necessary to perform functions such as thermal protection and landing, without significantly altering the primary subsystems and outer mold line of the original expendable vehicle. In addition, some of the propellant normally used for ascent is used instead for additional propulsive maneuvers after staging in order to return both stages to the launch site, keep loads within acceptable limits and perform a soft landing. This paper presents a performance analysis that was performed to investigate the feasibility of this approach by quantifying the reduction in payload capability of the original expendable launch vehicle after accounting for the mass additions, trajectory changes and increased propellant requirements necessary for reusability. Results show that it is feasible to return both stages to the launch site with a positive payload capability equal to approximately 50 percent of an equivalent expendable launch vehicle. Further discussion examines the ability to return a crew/cargo capsule to the launch site and presents technical challenges that would have to be overcome.

  15. Retinal orientation and interactions in rhodopsin reveal a two-stage trigger mechanism for activation

    PubMed Central

    Kimata, Naoki; Pope, Andreyah; Eilers, Markus; Opefi, Chikwado A.; Ziliox, Martine; Hirshfeld, Amiram; Zaitseva, Ekaterina; Vogel, Reiner; Sheves, Mordechai; Reeves, Philip J.; Smith, Steven O.

    2016-01-01

    The 11-cis retinal chromophore is tightly packed within the interior of the visual receptor rhodopsin and isomerizes to the all-trans configuration following absorption of light. The mechanism by which this isomerization event drives the outward rotation of transmembrane helix H6, a hallmark of activated G protein-coupled receptors, is not well established. To address this question, we use solid-state NMR and FTIR spectroscopy to define the orientation and interactions of the retinal chromophore in the active metarhodopsin II intermediate. Here we show that isomerization of the 11-cis retinal chromophore generates strong steric interactions between its β-ionone ring and transmembrane helices H5 and H6, while deprotonation of its protonated Schiff's base triggers the rearrangement of the hydrogen-bonding network involving residues on H6 and within the second extracellular loop. We integrate these observations with previous structural and functional studies to propose a two-stage mechanism for rhodopsin activation. PMID:27585742

  16. Two-stage categorization in brand extension evaluation: electrophysiological time course evidence.

    PubMed

    Ma, Qingguo; Wang, Cuicui; Wang, Xiaoyi

    2014-01-01

    A brand name can be considered a mental category. Similarity-based categorization theory has been used to explain how consumers judge a new product as a member of a known brand, a process called brand extension evaluation. This study was an event-related potential study conducted in two experiments. The study found a two-stage categorization process reflected by the P2 and N400 components in brand extension evaluation. In experiment 1, a prime-probe paradigm was presented in a pair consisting of a brand name and a product name in three conditions, i.e., in-category extension, similar-category extension, and out-of-category extension. Although the task was unrelated to brand extension evaluation, P2 distinguished out-of-category extensions from similar-category and in-category ones, and N400 distinguished similar-category extensions from in-category ones. In experiment 2, a prime-probe paradigm with a related task was used, in which product names included subcategory and major-category product names. The N400 elicited by subcategory products was more significantly negative than that elicited by major-category products, with no salient difference in P2. We speculated that P2 could reflect the early low-level and similarity-based processing in the first stage, whereas N400 could reflect the late analytic and category-based processing in the second stage.

  17. Fast acquisition of cooperation and trust: A two-stage view of trusting behavior

    PubMed Central

    Schmid, Tom L.; Hake, Don F.

    1983-01-01

    Trustful behavior was defined in terms of the consecutive numbers of matching-to-sample problems worth money that each subject worked during sessions that ended in an equitable distribution. Two stages of acquisition are inherent in this definition; the first stage requires acquisition of an equitable method of distributing reinforcers (cooperation) to show that the within-session deviations (trust) from equity that develop during the second stage are temporary and are not part of an inequitable method of distributing reinforcers. Previous research has indicated that a contingency to trust is necessary to override the aversiveness of the inequity inherent in trusting and to produce consistent and maximal trust (half of the problems worked consecutively by each subject). The present experiment examined such a contingency. The trust contingency was an increased requirement for changing the direction of problem allocation. Only the subject who had been allocated a problem could change that allocation, by pulling a lever 45 or more times. On the other hand, no separate responses were required to allow the person who worked the last problem to also work the next one (passive trust). Hence, giving a problem was the only way to increase the distribution of problems to the other person and hence prevent oneself from receiving all of the reinforcers. All eight pairs of subjects cooperated from the outset. Trusting behavior developed for all four pairs exposed to the contingency to trust and expanded to maximal levels by the second session for three of the four pairs. PMID:16812342

  18. The performance of a two-stage SBR system in treating dye containing wastewater.

    PubMed

    Won, X H; Fu, L Y; Oian, Y

    2003-01-01

    A two-stage SBR system treating the wastewater containing copper-phthalocyanin dye-Reactive Turquoise Blue KN-G (C. I. Reactive Blue 21, denoted by RTB) was investigated during a 200-cycle operation. The performance of the system, including pollutant removal rates, operating stability and sludge characteristics, may be a concern in the long-term run. The results shows that the system removed RTB efficiently despite the step-up RTB concentration from 13.1 to 107 mg/L in the influent. The average total removal rates of RTB were 81% to 92.5% due to the contribution of both anaerobic and aerobic stages, while stable effluent was produced with the help of the aerobic stage. The sludge in each reactor was in the steady state and of good activity on RTB removal. Moreover, the anaerobic sludge with the SVI value of 109.1 and the aerobic sludge with the SVI value of 103.2 had good settling properties, which was verified by hardly any presence of suspended solids in the effluent and an observation under an electron-scanning microscope. The adsorption and biodegradation were considered as the mechanism for the stability of the SBR system during the long-term run.

  19. Depth-dependent extension, two-stage breakup and cratonic underplating at rifted margins.

    PubMed

    Huismans, Ritske; Beaumont, Christopher

    2011-05-01

    Uniform lithospheric extension predicts basic properties of non-volcanic rifted margins but fails to explain other important characteristics. Significant discrepancies are observed at 'type I' margins (such as the Iberia-Newfoundland conjugates), where large tracts of continental mantle lithosphere are exposed at the sea floor, and 'type II' margins (such as some ultrawide central South Atlantic margins), where thin continental crust spans wide regions below which continental lower crust and mantle lithosphere have apparently been removed. Neither corresponds to uniform extension. Instead, either crust or mantle lithosphere has been preferentially removed. Using dynamical models, we demonstrate that these margins are opposite end members: in type I, depth-dependent extension results in crustal-necking breakup before mantle-lithosphere breakup and in type II, the converse is true. These two-layer, two-stage breakup behaviours explain the discrepancies and have implications for the styles of the associated sedimentary basins. Laterally flowing lower-mantle cratonic lithosphere may underplate some type II margins, thereby contributing to their anomalous characteristics.

  20. Antioxidant activity and total phenolic content of Moringa oleifera leaves in two stages of maturity.

    PubMed

    Sreelatha, S; Padma, P R

    2009-12-01

    Antioxidants play an important role in inhibiting and scavenging free radicals, thus providing protection to human against infections and degenerative diseases. Current research is now directed towards natural antioxidants originated from plants due to safe therapeutics. Moringa oleifera is used in Indian traditional medicine for a wide range of various ailments. To understand the mechanism of pharmacological actions, antioxidant properties of the Moringa oleifera leaf extracts were tested in two stages of maturity using standard in vitro models. The successive aqueous extract of Moringa oleifera exhibited strong scavenging effect on 2, 2-diphenyl-2-picryl hydrazyl (DPPH) free radical, superoxide, nitric oxide radical and inhibition of lipid per oxidation. The free radical scavenging effect of Moringa oleifera leaf extract was comparable with that of the reference antioxidants. The data obtained in the present study suggests that the extracts of Moringa oleifera both mature and tender leaves have potent antioxidant activity against free radicals, prevent oxidative damage to major biomolecules and afford significant protection against oxidative damage. PMID:19904611

  1. A two-stage Bayesian design for co-development of new drugs and companion diagnostics.

    PubMed

    Karuri, Stella Wanjugu; Simon, Richard

    2012-05-10

    Most new drug development in oncology is based on targeting specific molecules. Genomic profiles and deregulated drug targets vary from patient to patient making new treatments likely to benefit only a subset of patients traditionally grouped in the same clinical trials. Predictive biomarkers are being developed to identify patients who are most likely to benefit from a particular treatment; however, their biological basis is not always conclusive. The inclusion of marker-negative patients in a trial is therefore sometimes necessary for a more informative evaluation of the therapy. In this paper, we present a two-stage Bayesian design that includes both marker-positive and marker-negative patients in a clinical trial. We formulate a family of prior distributions that represent the degree of a priori confidence in the predictive biomarker. To avoid exposing patients to a treatment to which they may not be expected to benefit, we perform an interim analysis that may stop accrual of marker-negative patients or accrual of all patients. We demonstrate with simulations that the design and priors used control type I errors, give adequate power, and enable the early futility analysis of test-negative patients to be based on prior specification on the strength of evidence in the biomarker.

  2. Nitrification and microalgae cultivation for two-stage biological nutrient valorization from source separated urine.

    PubMed

    Coppens, Joeri; Lindeboom, Ralph; Muys, Maarten; Coessens, Wout; Alloul, Abbas; Meerbergen, Ken; Lievens, Bart; Clauwaert, Peter; Boon, Nico; Vlaeminck, Siegfried E

    2016-07-01

    Urine contains the majority of nutrients in urban wastewaters and is an ideal nutrient recovery target. In this study, stabilization of real undiluted urine through nitrification and subsequent microalgae cultivation were explored as strategy for biological nutrient recovery. A nitrifying inoculum screening revealed a commercial aquaculture inoculum to have the highest halotolerance. This inoculum was compared with municipal activated sludge for the start-up of two nitrification membrane bioreactors. Complete nitrification of undiluted urine was achieved in both systems at a conductivity of 75mScm(-1) and loading rate above 450mgNL(-1)d(-1). The halotolerant inoculum shortened the start-up time with 54%. Nitrite oxidizers showed faster salt adaptation and Nitrobacter spp. became the dominant nitrite oxidizers. Nitrified urine as growth medium for Arthrospira platensis demonstrated superior growth compared to untreated urine and resulted in a high protein content of 62%. This two-stage strategy is therefore a promising approach for biological nutrient recovery. PMID:26998796

  3. Destruction of chlorobenzene and carbon tetrachloride in a two-stage molten salt oxidation reactor system.

    PubMed

    Yang, Hee-Chul; Cho, Yong-Jun; Eun, Hee-Chul; Kim, Eung-Ho

    2008-08-01

    Molten salt oxidation (MSO) is one of the promising alternative destruction technologies for chlorinated organics, because it is capable of trapping chlorine during organic destruction. This study investigated the characteristics of a two-stage MSO reactor system for the destruction of CCl(4) and C(6)H(5)Cl. Investigated parameters were the MSO reactor temperature (from 1023 K to 1223 K) and the excess oxidizing air feed rate (50% and 100%). The destruction of chlorinated solvents is substantial in the Li(2)CO(3)-Na(2)CO(3) eutectic molten salt, irrespective of the tested condition. However, further oxidation of CO, which is found to be the major destruction product, is not substantial due to the limited temperature and gas residence time in the MSO reactor. Increases in the reactor temperature as well as those in the oxidizing air feed rate consistently lead to decreased emissions of carbon monoxide. No significant influence of the MSO reactor operating condition on the chlorine capturing efficiency was found. Over 99.95% and 99.997% of the chlorine was captured in the hot MSO reactors during the C(6)H(5)Cl and CCl(4) destructions, respectively. This result suggests a relatively low potential of the MSO system in the recombination of chlorinated organics, when compared to a conventional incineration system. PMID:18501405

  4. Operating experience of 75 t/h two stage circulating fluidized bed boiler

    SciTech Connect

    Tang, M.S.; Li, X.; Liu, D.C.

    1999-07-01

    Two 2-stage circulating fluidized bed combustion boilers have been put into operation in the Pacific Ocean Cogeneration Company for 3 years. After being put into operation these boilers had the following problems: Steam Capacity was less than the design value; Fly ash collecting efficiency of the two stage separators was lower, resulting in lower combustion efficiency and higher coal consumption; Refractory bricks of the furnace roof frequently fell off; and Bed temperature at the low part of the combustion chamber was higher than 1,050 C, resulting in lower de-SO{sub x} efficiency. In order to improve combustion efficiency, save fuel and prolong the duration of runs, the following technology improvements have been adopted: Replacing the second stage louver separator with two horizontal louver cyclone separators. This improved the fly ash collecting efficiency; and An additional membrane wall is placed at the furnace roof to support the refractory bricks, prevent refractory bricks from falling off, and prolong the duration of runs. After these improvements, the boiler can run stably at design conditions and the boiler efficiency reaches 80.1%, 5 percentage points higher than before; the bed temperature can be controlled in the range of 900{approximately}950 C; the refractory bricks of the furnace roof have not fallen off.

  5. Experimental Studies on a Two Stage Pulse Tube Cryocooler Reaching 2.5K

    NASA Astrophysics Data System (ADS)

    Kasthurirengan, S.; Srinivasa, G.; Karthik, G. S.; Ramesh, K. P.; Shafi, K. A.

    2008-03-01

    A two stage Pulse Tube Cryocooler (PTC) is designed and fabricated which reaches a no-load temperature of 2.5K in the second stage and ˜60 K in the first stage respectively. The system provides a cooling power of ˜250 mW at 5K in the second stage. Stainless steel meshes (size 200) and lead (Pb) granules are used as the first stage regenerator materials and combination of Pb with Er3Ni/HoCu2 are used as the second stage regenerator materials. The system operates at 1.6 Hz using a 6 kW water cooled helium compressor. Studies conducted by varying the dimensions of Pulse Tubes and regenerators show that the dimensions of the Pulse Tubes are more critical to the performance of the Cryocooler than those of the regenerators. Experimental studies show that the optimum volume ratios of Er3Ni to Pb and HoCu2 to Pb in the second stage regenerator should be ˜3:2 and 2:3 respectively for the best performance. Further, systems with HoCu2 performed better than those with Er3Ni. The theoretical analysis of the system has been carried out using a simple isothermal model. The experimentally measured cooling powers are in good agreement with the theoretical predictions.

  6. Orbiter Trajectory Analysis for a Two-Stage Reusable Launch Vehicle

    NASA Technical Reports Server (NTRS)

    Cowling, Adam L.

    2011-01-01

    Trajectory analysis performed on NASA's reference two-stage-to-orbit launch vehicle upper stage will be presented. The work was completed in support of the Hypersonics Multidisciplinary Analysis and Optimization effort for the NASA-Air Force Joint System Study. Three degree-of-freedom (3-DOF) untrimmed trajectory analysis was performed for the orbiter ascent, closure and re-entry. An iterative closure process resulted in a 333,000 lb initial mass for the orbiter. The re-entry trajectory satisfied heating constraints for all payload out cases and met the constraints with reduced margins for payload in cases. Abort trajectories for engine out at staging, engine out during ascent, and failure to circularize in orbit, gave insight to the robustness of the orbiter. A trimmed ascent trajectory defined an engine gimbal location and the body flap angle best suited for maximizing injected mass. A trimmed re-entry trajectory revealed a need to update the trim routine to accommodate full flap aerodynamic data.

  7. Characterisation of the current switch mechanism in two-stage wire array Z-pinches

    SciTech Connect

    Burdiak, G. C.; Lebedev, S. V.; Harvey-Thompson, A. J.; Hall, G. N.; Swadling, G. F.; Suzuki-Vidal, F.; Khoory, E.; Bland, S. N.; Pickworth, L.; Grouchy, P. de; Skidmore, J.; Suttle, L.; Waisman, E. M.

    2015-11-15

    In this paper, we describe the operation of a two-stage wire array z-pinch driven by the 1.4 MA, 240 ns rise-time Magpie pulsed-power device at Imperial College London. In this setup, an inverse wire array acts as a fast current switch, delivering a current pre-pulse into a cylindrical load wire array, before rapidly switching the majority of the generator current into the load after a 100–150 ns dwell time. A detailed analysis of the evolution of the load array during the pre-pulse is presented. Measurements of the load resistivity and energy deposition suggest significant bulk heating of the array mass occurs. The ∼5 kA pre-pulse delivers ∼0.8 J of energy to the load, leaving it in a mixed, predominantly liquid-vapour state. The main current switch occurs as the inverse array begins to explode and plasma expands into the load region. Electrical and imaging diagnostics indicate that the main current switch may evolve in part as a plasma flow switch, driven by the expansion of a magnetic cavity and plasma bubble along the length of the load array. Analysis of implosion trajectories suggests that approximately 1 MA switches into the load in 100 ns, corresponding to a doubling of the generator dI/dt. Potential scaling of the device to higher current machines is discussed.

  8. Retinal orientation and interactions in rhodopsin reveal a two-stage trigger mechanism for activation.

    PubMed

    Kimata, Naoki; Pope, Andreyah; Eilers, Markus; Opefi, Chikwado A; Ziliox, Martine; Hirshfeld, Amiram; Zaitseva, Ekaterina; Vogel, Reiner; Sheves, Mordechai; Reeves, Philip J; Smith, Steven O

    2016-01-01

    The 11-cis retinal chromophore is tightly packed within the interior of the visual receptor rhodopsin and isomerizes to the all-trans configuration following absorption of light. The mechanism by which this isomerization event drives the outward rotation of transmembrane helix H6, a hallmark of activated G protein-coupled receptors, is not well established. To address this question, we use solid-state NMR and FTIR spectroscopy to define the orientation and interactions of the retinal chromophore in the active metarhodopsin II intermediate. Here we show that isomerization of the 11-cis retinal chromophore generates strong steric interactions between its β-ionone ring and transmembrane helices H5 and H6, while deprotonation of its protonated Schiff's base triggers the rearrangement of the hydrogen-bonding network involving residues on H6 and within the second extracellular loop. We integrate these observations with previous structural and functional studies to propose a two-stage mechanism for rhodopsin activation. PMID:27585742

  9. Experimental development of a two-stage fluidized-bed/cyclonic agglomerating incinerator

    SciTech Connect

    Mensinger, M.C.; Rehmat, A.; Bryan, B.G.; Lau, F.S. ); Shearer, T.L. ); Duggan, P.A. )

    1991-01-01

    The Institute of Gas Technology (IGT) is conducting an experimental program to develop and test through pilot-plant scale of operation, IGT's two-stage fluidized-bed/cyclonic agglomerating incinerator (TSI). The TSI is based on combining the fluidized-bed agglomeration/gasification technology and the cyclonic combustion/incineration technology, which have been developed at IGT over many years. The TSI is a unique and extremely flexible combustor that can operate over a wide range of conditions in the fluidized-bed first stage from low temperature (desorption) to high temperature (agglomeration) including gasification of high-Btu wastes. The TSI can easily and efficiently destroy solid, liquid and gaseous organic wastes, while containing solid inorganic contaminants within an essentially non-leachable glassy matrix, suitable for disposal in an ordinary landfill. This paper presents the results of tests conducted in a batch, fluidized-bed bench-scale unit (BSU) with commercially available clean'' top soil and the same soil spiked with lead and chromium compounds. The objectives of these tests were to determine the operating conditions necessary to achieve soil agglomeration and to evaluate the leaching characteristics of the soil agglomerates formed. 7 refs., 7 figs., 6 tabs.

  10. Treatment of Ammonia Nitrogen Wastewater in Low Concentration by Two-Stage Ozonization.

    PubMed

    Luo, Xianping; Yan, Qun; Wang, Chunying; Luo, Caigui; Zhou, Nana; Jian, Chensheng

    2015-09-01

    Ammonia nitrogen wastewater (about 100 mg/L) was treated by two-stage ozone oxidation method. The effects of ozone flow rate and initial pH on ammonia removal were studied, and the mechanism of ammonia nitrogen removal by ozone oxidation was discussed. After the primary stage of ozone oxidation, the ammonia removal efficiency reached 59.32% and pH decreased to 6.63 under conditions of 1 L/min ozone flow rate and initial pH 11. Then, the removal efficiency could be over 85% (the left ammonia concentration was lower than 15 mg/L) after the second stage, which means the wastewater could have met the national discharge standards of China. Besides, the mechanism of ammonia removal by ozone oxidation was proposed by detecting the products of the oxidation: ozone oxidation directly and ·OH oxidation; ammonia was mainly transformed into NO₃(-)-N, less into NO₂(-)-N, not into N₂. PMID:26404353

  11. A cooperation model based on CVaR measure for a two-stage supply chain

    NASA Astrophysics Data System (ADS)

    Xu, Xinsheng; Meng, Zhiqing; Shen, Rui

    2015-07-01

    In this paper, we introduce a cooperation model (CM) for the two-stage supply chain consisting of a manufacturer and a retailer. In this model, it is supposed that the objective of the manufacturer is to maximise his/her profit while the objective of the retailer is to minimise his/her CVaR while controlling the risk originating from fluctuation in market demand. In reality, the manufacturer and the retailer would like to choose their own decisions as to wholesale price and order quantity to optimise their own objectives, resulting the fact that the expected decision of the manufacturer and that of the retailer may conflict with each other. Then, to achieve cooperation, the manufacturer and the retailer both need to give some concessions. The proposed model aims to coordinate the decisions of the manufacturer and the retailer, and balance the concessions of the two in their cooperation. We introduce an s* - optimal equilibrium solution in this model, which can decide the minimum concession that the manufacturer and the retailer need to give for their cooperation, and prove that the s* - optimal equilibrium solution can be obtained by solving a goal programming problem. Further, the case of different concessions made by the manufacturer and the retailer is also discussed. Numerical results show that the CM is efficient in dealing with the cooperations between the supplier and the retailer.

  12. Manufacture of gradient micro-structures of magnesium alloys using two stage extrusion dies

    SciTech Connect

    Hwang, Yeong-Maw; Huang, Tze-Hui; Alexandrov, Sergei; Naimark, Oleg Borisovich; Jeng, Yeau-Ren

    2013-12-16

    This paper aims to manufacture magnesium alloy metals with gradient micro-structures using hot extrusion process. The extrusion die was designed to have a straight channel part combined with a conical part. Materials pushed through this specially-designed die generate a non-uniform velocity distribution at cross sections inside the die and result in different strain and strain rate distributions. Accordingly, a gradient microstructure product can be obtained. Using the finite element analysis, the forming temperature, effective strain, and effective strain rate distributions at the die exit were firstly discussed for various inclination angles in the conical die. Then, hot extrusion experiments with a two stage die were conducted to obtain magnesium alloy products with gradient micro-structures. The effects of the inclination angle on the grain size distribution at cross sections of the products were also discussed. Using a die of an inclination angle of 15°, gradient micro-structures of the grain size decreasing gradually from 17 μm at the center to 4 μm at the edge of product were achieved.

  13. Viroporins, Examples of the Two-Stage Membrane Protein Folding Model

    PubMed Central

    Martinez-Gil, Luis; Mingarro, Ismael

    2015-01-01

    Viroporins are small, α-helical, hydrophobic virus encoded proteins, engineered to form homo-oligomeric hydrophilic pores in the host membrane. Viroporins participate in multiple steps of the viral life cycle, from entry to budding. As any other membrane protein, viroporins have to find the way to bury their hydrophobic regions into the lipid bilayer. Once within the membrane, the hydrophobic helices of viroporins interact with each other to form higher ordered structures required to correctly perform their porating activities. This two-step process resembles the two-stage model proposed for membrane protein folding by Engelman and Poppot. In this review we use the membrane protein folding model as a leading thread to analyze the mechanism and forces behind the membrane insertion and folding of viroporins. We start by describing the transmembrane segment architecture of viroporins, including the number and sequence characteristics of their membrane-spanning domains. Next, we connect the differences found among viroporin families to their viral genome organization, and finalize focusing on the pathways used by viroporins in their way to the membrane and on the transmembrane helix-helix interactions required to achieve proper folding and assembly. PMID:26131957

  14. A comprehensive microbial insight into two-stage anaerobic digestion of food waste-recycling wastewater.

    PubMed

    Shin, Seung Gu; Han, Gyuseong; Lim, Juntaek; Lee, Changsoo; Hwang, Seokhwan

    2010-09-01

    Microbial community structures were assessed in a two-stage anaerobic digestion system treating food waste-recycling wastewater. The reactors were operated for 390 d at 10 different hydraulic retention times (HRTs) ranging from 25 to 4 d. Stable operation was achieved with the overall chemical oxygen demand (COD) removal efficiency of 73.0-85.9% at organic loading rate of up to 35.6 g COD/L·d. Performance of the acidogenic reactors, however, changed significantly during operation. This change coincided with transition of the bacterial community from one dominated by Aeriscardovia- and Lactobacillus amylovorus-related species to one dominated by Lactobacillus acetotolerans- and Lactobacillus kefiri-like organisms. In methanogenic reactors, the microbial community structures also changed at this stage along with the shift from Methanoculleus- to Methanosarcina-like organisms. This trend was confirmed by the non-metric multidimensional scaling joint plot of microbial shifts along with performance parameters. These results indicated that the overall process performance was relatively stable compared to the dynamic changes in the microbial structures and the acidogenic performance.

  15. Two-stage acceleration of protons from relativistic laser-solid interaction

    SciTech Connect

    Liu Jinlu; Sheng, Z. M.; Zheng, J.; Wang, W. M.; Yu, M. Y.; Liu, C. S.; Zhang, J.

    2012-12-21

    A two-stage proton acceleration scheme using present-day intense lasers and a unique target design is proposed. The target system consists of a hollow cylinder, inside which is a hollow cone, which is followed by the main target with a flat front and dish-like flared rear surface. At the center of the latter is a tapered proton layer, which is surrounded by outer proton layers at an angle to it. In the first acceleration stage, protons in both layers are accelerated by target normal sheath acceleration. The center-layer protons are accelerated forward along the axis and the side protons are accelerated and focused towards them. As a result, the side-layer protons radially compress as well as axially further accelerate the front part of the accelerating center-layer protons in the second stage, which are also radially confined and guided by the field of the fast electrons surrounding them. Two-dimensional particle-incell simulation shows that a 79fs 8.5 Multiplication-Sign 10{sup 20} W/cm{sup 2} laser pulse can produce a proton bunch with {approx} 267MeV maximum energy and {approx} 9.5% energy spread, which may find many applications, including cancer therapy.

  16. A two-stage storage routing model for green roof runoff detention.

    PubMed

    Vesuviano, Gianni; Sonnenwald, Fred; Stovin, Virginia

    2014-01-01

    Green roofs have been adopted in urban drainage systems to control the total quantity and volumetric flow rate of runoff. Modern green roof designs are multi-layered, their main components being vegetation, substrate and, in almost all cases, a separate drainage layer. Most current hydrological models of green roofs combine the modelling of the separate layers into a single process; these models have limited predictive capability for roofs not sharing the same design. An adaptable, generic, two-stage model for a system consisting of a granular substrate over a hard plastic 'egg box'-style drainage layer and fibrous protection mat is presented. The substrate and drainage layer/protection mat are modelled separately by previously verified sub-models. Controlled storm events are applied to a green roof system in a rainfall simulator. The time-series modelled runoff is compared to the monitored runoff for each storm event. The modelled runoff profiles are accurate (mean Rt(2) = 0.971), but further characterization of the substrate component is required for the model to be generically applicable to other roof configurations with different substrate.

  17. Destruction of chlorobenzene and carbon tetrachloride in a two-stage molten salt oxidation reactor system.

    PubMed

    Yang, Hee-Chul; Cho, Yong-Jun; Eun, Hee-Chul; Kim, Eung-Ho

    2008-08-01

    Molten salt oxidation (MSO) is one of the promising alternative destruction technologies for chlorinated organics, because it is capable of trapping chlorine during organic destruction. This study investigated the characteristics of a two-stage MSO reactor system for the destruction of CCl(4) and C(6)H(5)Cl. Investigated parameters were the MSO reactor temperature (from 1023 K to 1223 K) and the excess oxidizing air feed rate (50% and 100%). The destruction of chlorinated solvents is substantial in the Li(2)CO(3)-Na(2)CO(3) eutectic molten salt, irrespective of the tested condition. However, further oxidation of CO, which is found to be the major destruction product, is not substantial due to the limited temperature and gas residence time in the MSO reactor. Increases in the reactor temperature as well as those in the oxidizing air feed rate consistently lead to decreased emissions of carbon monoxide. No significant influence of the MSO reactor operating condition on the chlorine capturing efficiency was found. Over 99.95% and 99.997% of the chlorine was captured in the hot MSO reactors during the C(6)H(5)Cl and CCl(4) destructions, respectively. This result suggests a relatively low potential of the MSO system in the recombination of chlorinated organics, when compared to a conventional incineration system.

  18. Two-Stage Fungal Pre-Treatment for Improved Biogas Production from Sisal Leaf Decortication Residues

    PubMed Central

    Muthangya, Mutemi; Mshandete, Anthony Manoni; Kivaisi, Amelia Kajumulo

    2009-01-01

    Sisal leaf decortications residue (SLDR) is amongst the most abundant agro-industrial residues in Tanzania and is a good feedstock for biogas production. Pre-treatment of the residue prior to its anaerobic digestion (AD) was investigated using a two-stage pre-treatment approach with two fungal strains, CCHT-1 and Trichoderma reesei in succession in anaerobic batch bioreactors. AD of the pre-treated residue with CCTH-1 at 10% (wet weight inoculum/SLDR) inoculum concentration incubated for four days followed by incubation for eight days with 25% (wet weight inoculum/SLDR) of T. reesei gave a methane yield of 0.292 ± 0.04 m3 CH4/kg volatile solids (VS)added. On reversing the pre-treatment succession of the fungal inocula using the same parameters followed by AD, methane yield decreased by about 55%. Generally, an increment in the range of 30–101% in methane yield in comparison to the un-treated SLDR was obtained. The results confirmed the potential of CCHT-1 followed by Trichoderma reesei fungi pre-treatment prior to AD to achieve significant improvement in biogas production from SLDR. PMID:20087466

  19. Beyond Two-Stage Models for Lung Carcinogenesis in the Mayak Workers: Implications for Plutonium Risk

    PubMed Central

    Zöllner, Sascha; Sokolnikov, Mikhail E.; Eidemüller, Markus

    2015-01-01

    Mechanistic multi-stage models are used to analyze lung-cancer mortality after Plutonium exposure in the Mayak-workers cohort, with follow-up until 2008. Besides the established two-stage model with clonal expansion, models with three mutation stages as well as a model with two distinct pathways to cancer are studied. The results suggest that three-stage models offer an improved description of the data. The best-fitting models point to a mechanism where radiation increases the rate of clonal expansion. This is interpreted in terms of changes in cell-cycle control mediated by bystander signaling or repopulation following cell killing. No statistical evidence for a two-pathway model is found. To elucidate the implications of the different models for radiation risk, several exposure scenarios are studied. Models with a radiation effect at an early stage show a delayed response and a pronounced drop-off with older ages at exposure. Moreover, the dose-response relationship is strongly nonlinear for all three-stage models, revealing a marked increase above a critical dose. PMID:26000637

  20. Two-stage Framework for a Topology-Based Projection and Visualization of Classified Document Collections

    SciTech Connect

    Oesterling, Patrick; Scheuermann, Gerik; Teresniak, Sven; Heyer, Gerhard; Koch, Steffen; Ertl, Thomas; Weber, Gunther H.

    2010-07-19

    During the last decades, electronic textual information has become the world's largest and most important information source available. People have added a variety of daily newspapers, books, scientific and governmental publications, blogs and private messages to this wellspring of endless information and knowledge. Since neither the existing nor the new information can be read in its entirety, computers are used to extract and visualize meaningful or interesting topics and documents from this huge information clutter. In this paper, we extend, improve and combine existing individual approaches into an overall framework that supports topological analysis of high dimensional document point clouds given by the well-known tf-idf document-term weighting method. We show that traditional distance-based approaches fail in very high dimensional spaces, and we describe an improved two-stage method for topology-based projections from the original high dimensional information space to both two dimensional (2-D) and three dimensional (3-D) visualizations. To show the accuracy and usability of this framework, we compare it to methods introduced recently and apply it to complex document and patent collections.

  1. Quantum treatment of two-stage sub-Doppler laser cooling of magnesium atoms

    NASA Astrophysics Data System (ADS)

    Prudnikov, O. N.; Brazhnikov, D. V.; Taichenachev, A. V.; Yudin, V. I.; Bonert, A. E.; Il'enkov, R. Ya.; Goncharov, A. N.

    2015-12-01

    Deep laser cooling of 24Mg atoms has been theoretically studied. We propose a two-stage sub-Doppler cooling strategy using electrodipole transition 3 3P2→3 3D3 (λ =383.8 nm). The first stage implies exploiting magneto-optical trap with σ+ and σ- light beams, while at the second stage lin ⊥ lin molasses is used. We focus on achieving a large number of ultracold atoms (Teff<10 μ K ) in a cold-atomic cloud. The calculations have been based on quantum treatment, taking into full account the recoil effect and beyond many widely used approximations. Steady-state values of average kinetic energy and linear momentum distributions of cold atoms have been analyzed for various light-field intensities and frequency detunings. The results of conducted quantum analysis have been significantly different from the results achieved under a semiclassical approximation based on the Fokker-Planck equation. The second cooling stage allows achieving sufficiently lower kinetic energies of the atomic cloud as well as increased fraction of ultracold atoms at certain conditions compared to the first one. We hope that the obtained results can help in overcoming current experimental problems in deep cooling of 24Mg atoms by means of laser field. Cold magnesium atoms cooled in a large amount to several μ K are of huge interest to, for example, quantum metrology and to other many-body cold-atoms physics.

  2. Two-Stage Categorization in Brand Extension Evaluation: Electrophysiological Time Course Evidence

    PubMed Central

    Wang, Xiaoyi

    2014-01-01

    A brand name can be considered a mental category. Similarity-based categorization theory has been used to explain how consumers judge a new product as a member of a known brand, a process called brand extension evaluation. This study was an event-related potential study conducted in two experiments. The study found a two-stage categorization process reflected by the P2 and N400 components in brand extension evaluation. In experiment 1, a prime–probe paradigm was presented in a pair consisting of a brand name and a product name in three conditions, i.e., in-category extension, similar-category extension, and out-of-category extension. Although the task was unrelated to brand extension evaluation, P2 distinguished out-of-category extensions from similar-category and in-category ones, and N400 distinguished similar-category extensions from in-category ones. In experiment 2, a prime–probe paradigm with a related task was used, in which product names included subcategory and major-category product names. The N400 elicited by subcategory products was more significantly negative than that elicited by major-category products, with no salient difference in P2. We speculated that P2 could reflect the early low-level and similarity-based processing in the first stage, whereas N400 could reflect the late analytic and category-based processing in the second stage. PMID:25438152

  3. Integrated two-stage chemically processing of rice straw cellulose to butyl levulinate.

    PubMed

    Elumalai, Sasikumar; Agarwal, Bhumica; Runge, Troy M; Sangwan, Rajender S

    2016-10-01

    A two-stage reaction system was developed to synthesize butyl levulinate (BL), a derivative chemical of levulinic acid, from agricultural residue (rice straw). A single reactor was employed during the first processing stage for the conversion of rice straw cellulose to levulinic acid (LA) in a novel co-solvent system consisting of dilute phosphoric acid and tetrahydrofuran. The highest yield of 10.8% wt. LA concentration (i.e., ∼42% of theoretical LA yield) with intermediate residuals concentration of 1.5% wt. glucose and 0.5% wt. 5-hydroxymethylfurfural (5-HMF) on dry weight basis of biomass was obtained at modest reaction conditions. During subsequent esterification reaction, approximately 7.8% wt. BL yield (at 89% conversion yield) was achieved from the solvent extracted precipitate containing majorly LA and residual 5-HMF in the presence of 0.5M sulfuric acid using n-butanol. Based on comparative esterification results obtained using commercial chemicals (LA and 5-HMF), apparently 5-HMF exhibited ∼8% wt. BL yield through direct synthesis in the presence of sulfuric acid using n-butanol under the same specified reaction conditions. Alongside, effectiveness of co-solvent treatment on rice straw for potential fermentable sugar release (glucose) was investigated by subjecting the respective post-reaction solid residues to enzymatic digestion using cellulase and yielded highest of 11% wt. per wt. solids (27% wt. glucose conversion efficiency), amongst solid residues underwent different processing conditions. PMID:27312640

  4. Two-stage categorization in brand extension evaluation: electrophysiological time course evidence.

    PubMed

    Ma, Qingguo; Wang, Cuicui; Wang, Xiaoyi

    2014-01-01

    A brand name can be considered a mental category. Similarity-based categorization theory has been used to explain how consumers judge a new product as a member of a known brand, a process called brand extension evaluation. This study was an event-related potential study conducted in two experiments. The study found a two-stage categorization process reflected by the P2 and N400 components in brand extension evaluation. In experiment 1, a prime-probe paradigm was presented in a pair consisting of a brand name and a product name in three conditions, i.e., in-category extension, similar-category extension, and out-of-category extension. Although the task was unrelated to brand extension evaluation, P2 distinguished out-of-category extensions from similar-category and in-category ones, and N400 distinguished similar-category extensions from in-category ones. In experiment 2, a prime-probe paradigm with a related task was used, in which product names included subcategory and major-category product names. The N400 elicited by subcategory products was more significantly negative than that elicited by major-category products, with no salient difference in P2. We speculated that P2 could reflect the early low-level and similarity-based processing in the first stage, whereas N400 could reflect the late analytic and category-based processing in the second stage. PMID:25438152

  5. Flexible distributions for triple-goal estimates in two-stage hierarchical models

    PubMed Central

    Paddock, Susan M.; Ridgeway, Greg; Lin, Rongheng; Louis, Thomas A.

    2009-01-01

    Performance evaluations often aim to achieve goals such as obtaining estimates of unit-specific means, ranks, and the distribution of unit-specific parameters. The Bayesian approach provides a powerful way to structure models for achieving these goals. While no single estimate can be optimal for achieving all three inferential goals, the communication and credibility of results will be enhanced by reporting a single estimate that performs well for all three. Triple goal estimates [Shen and Louis, 1998. Triple-goal estimates in two-stage hierarchical models. J. Roy. Statist. Soc. Ser. B 60, 455–471] have this performance and are appealing for performance evaluations. Because triple-goal estimates rely more heavily on the entire distribution than do posterior means, they are more sensitive to misspecification of the population distribution and we present various strategies to robustify triple-goal estimates by using nonparametric distributions. We evaluate performance based on the correctness and efficiency of the robustified estimates under several scenarios and compare empirical Bayes and fully Bayesian approaches to model the population distribution. We find that when data are quite informative, conclusions are robust to model misspecification. However, with less information in the data, conclusions can be quite sensitive to the choice of population distribution. Generally, use of a nonparametric distribution pays very little in efficiency when a parametric population distribution is valid, but successfully protects against model misspecification. PMID:19603088

  6. Antioxidant activity and total phenolic content of Moringa oleifera leaves in two stages of maturity.

    PubMed

    Sreelatha, S; Padma, P R

    2009-12-01

    Antioxidants play an important role in inhibiting and scavenging free radicals, thus providing protection to human against infections and degenerative diseases. Current research is now directed towards natural antioxidants originated from plants due to safe therapeutics. Moringa oleifera is used in Indian traditional medicine for a wide range of various ailments. To understand the mechanism of pharmacological actions, antioxidant properties of the Moringa oleifera leaf extracts were tested in two stages of maturity using standard in vitro models. The successive aqueous extract of Moringa oleifera exhibited strong scavenging effect on 2, 2-diphenyl-2-picryl hydrazyl (DPPH) free radical, superoxide, nitric oxide radical and inhibition of lipid per oxidation. The free radical scavenging effect of Moringa oleifera leaf extract was comparable with that of the reference antioxidants. The data obtained in the present study suggests that the extracts of Moringa oleifera both mature and tender leaves have potent antioxidant activity against free radicals, prevent oxidative damage to major biomolecules and afford significant protection against oxidative damage.

  7. Effect of evening primrose and fish oils on two stage skin carcinogenesis in mice.

    PubMed

    Ramesh, G; Das, U N

    1998-09-01

    The effect of fish oil (FO, given in the form of MaxEPA) rich in n-3 fatty acids and evening primrose oil (EPO) rich in n-6 fatty acids on two-stage skin carcinogenesis in mice was studied. Both FO and EPO inhibited the papilloma formation to a significant degree only during the promotion stage which was associated with an increase in lipid peroxidation. Both FO and EPO inhibited the binding of benzo(a)-pyrene to skin cell DNA suggesting that this could be one of the mechanism(s) by which these oils could be preventing papilloma development. Neither EPO nor FO influenced epidermal cell proliferation. In the FO group, LA (linoleic acid), AA (arachidonic acid) and DHA (docosahexaenoic acid) were increased, whereas in the EPO group a significant increase in the AA content was noted. No specific changes in the fatty acid pattern were observed in any of the groups that could be attributed to the papilloma incidence. These results suggest that FO and EPO can influence papilloma formation which can be attributed, at least in part, to their ability to prevent benzo(a)pyrene binding to DNA and to an increase the lipid peroxidation process. PMID:9844986

  8. Acetic acid effects on methanogens in the second stage of a two-stage anaerobic system.

    PubMed

    Xiao, Keke; Guo, Chenghong; Zhou, Yan; Maspolim, Yogananda; Ng, Wun-Jern

    2016-02-01

    This study reports on biomass tolerance towards high concentrations of acetic acid (HAc) within the system. Biomass from the second stage of a two-stage anaerobic sludge digestion system was used for this study. Microbial community analysis by 454 pyrosequencing highlighted hydrogenotrophic Methanomicrobiales was the predominant archaeal population in the second stage (>99% of the total archaeal community). Second stage biomass degraded HAc up to 4200 mg HAc L(-1) without observable lag phase. However, at HAc-shock loading of 7400 mg HAc L(-1), it showed a one day lag phase associated with decreased biomass activity. After stepwise HAc-acclimation over 27 d, the biomass degraded HAc of up to 8200 mg HAc L(-1) without observable lag phase. The dominance of Methanomicrobiales had remained unchanged in proportion - while the total archaeal population increased during acclimation. This study showed stepwise acclimation could be an approach to accommodate HAc accumulation and hence higher concentrations resulting from an enhanced first stage. PMID:26498097

  9. End-wall boundary layer measurements in a two-stage fan

    NASA Technical Reports Server (NTRS)

    Ball, C. L.; Reid, L.; Schmidt, J. F.

    1983-01-01

    Detailed flow measurements made in the casing boundary layer of a two-stage transonic fan are summarized. These measurements were taken at a station upstream of the fan, between all blade rows, and downstream of the last row. Conventional boundary layer parameters were calculated from the measured data. A classical two dimensional casing boundary layer was measured at the fan inlet and extended inward to approximately 15 percent of span. A highly three dimensional boundary layer was measured at the exit of each blade row and extended inward to approximately 10 percent of span. The steep radial gradient of axial velocity noted at the exit of the rotors was reduced substantially as the flow passed through the stators. This reduced gradient is attributed to flow mixing. The amount of flow mixing was reflected in the radial redistribution of total temperature as the flow passed through the stators. The blockage factors calculated from the measured data show an increase in blockage across the rotors and a decrease across the stators. For this fan the calculated blockages for the second stage were essentially the same as those for the first stage.

  10. Two-stage hierarchical group testing for multiple infections with application to the Infertility Prevention Project

    PubMed Central

    Tebbs, Joshua M.; McMahan, Christopher S.; Bilder, Christopher R.

    2015-01-01

    Summary Screening for sexually transmitted diseases has benefited greatly from the use of group testing (pooled testing) to lower costs. With the development of assays that detect multiple infections, screening practices now involve testing pools of individuals for multiple infections simultaneously. Building on the research for single infection group testing procedures, we examine the performance of group testing for multiple infections. Our work is motivated by chlamydia and gonorrhea testing for the Infertility Prevention Project (IPP), a national program in the United States. We consider a two-stage pooling algorithm currently used to perform testing for the IPP. We first derive the operating characteristics of this algorithm for classification purposes (e.g., expected number of tests, misclassification probabilities, etc.) and identify pool sizes that minimize the expected number of tests. We then develop an expectation-maximization algorithm to estimate probabilities of infection using both group and individual retest responses. Our research shows that group testing can offer large cost savings when classifying individuals for multiple infections and can provide prevalence estimates that are actually more efficient than those from individual testing. PMID:24117173

  11. Viroporins, Examples of the Two-Stage Membrane Protein Folding Model.

    PubMed

    Martinez-Gil, Luis; Mingarro, Ismael

    2015-07-01

    Viroporins are small, α-helical, hydrophobic virus encoded proteins, engineered to form homo-oligomeric hydrophilic pores in the host membrane. Viroporins participate in multiple steps of the viral life cycle, from entry to budding. As any other membrane protein, viroporins have to find the way to bury their hydrophobic regions into the lipid bilayer. Once within the membrane, the hydrophobic helices of viroporins interact with each other to form higher ordered structures required to correctly perform their porating activities. This two-step process resembles the two-stage model proposed for membrane protein folding by Engelman and Poppot. In this review we use the membrane protein folding model as a leading thread to analyze the mechanism and forces behind the membrane insertion and folding of viroporins. We start by describing the transmembrane segment architecture of viroporins, including the number and sequence characteristics of their membrane-spanning domains. Next, we connect the differences found among viroporin families to their viral genome organization, and finalize focusing on the pathways used by viroporins in their way to the membrane and on the transmembrane helix-helix interactions required to achieve proper folding and assembly. PMID:26131957

  12. Confidence intervals for confirmatory adaptive two-stage designs with treatment selection.

    PubMed

    Bebu, Ionut; Dragalin, Vladimir; Luta, George

    2013-05-01

    The construction of adequate confidence intervals for adaptive two-stage designs remains an area of ongoing research. We propose a conditional likelihood-based approach to construct a Wald confidence interval and two confidence intervals based on inverting the likelihood ratio test, one of them using first-order inference methods and the second one using higher order inference methods. The coverage probabilities of these confidence intervals, and also the average bias and mean square error of the corresponding point estimates, compare favorably with other available techniques. A small simulation study is used to evaluate the performance of the new methods. We investigate other extensions of practical interest for normal endpoints and illustrate them using real data, including the selection of more than one treatment for the second stage, selection rules based on both efficacy and safety endpoints, and the inclusion of a control/placebo arm. The new method also allows adjustment for covariates, and has been extended to deal with binomial data and other distributions from the exponential family. Although conceptually simple, the new methods have a much wider scope than the methods currently available.

  13. Design of a High-Energy, Two-Stage Pulsed Plasma Thruster

    NASA Technical Reports Server (NTRS)

    Markusic, T. E.; Thio, Y. C. F.; Cassibry, J. T.; Rodgers, Stephen L. (Technical Monitor)

    2002-01-01

    Design details of a proposed high-energy (approx. 50 kJ/pulse), two-stage pulsed plasma thruster are presented. The long-term goal of this project is to develop a high-power (approx. 500 kW), high specific impulse (approx. 7500 s), highly efficient (approx. 50%),and mechanically simple thruster for use as primary propulsion in a high-power nuclear electric propulsion system. The proposed thruster (PRC-PPT1) utilizes a valveless, liquid lithium-fed thermal plasma injector (first stage) followed by a high-energy pulsed electromagnetic accelerator (second stage). A numerical circuit model coupled with one-dimensional current sheet dynamics, as well as a numerical MHD simulation, are used to qualitatively predict the thermal plasma injection and current sheet dynamics, as well as to estimate the projected performance of the thruster. A set of further modelling efforts, and the experimental testing of a prototype thruster, is suggested to determine the feasibility of demonstrating a full scale high-power thruster.

  14. Thrust augmentation options for the Beta 2 two-stage-to-orbit vehicle

    NASA Technical Reports Server (NTRS)

    Snyder, Christopher A.

    1993-01-01

    NASA LeRC is continuing to study propulsion concepts for a horizontal takeoff and landing, fully reusable, two-stage-to-orbit vehicle. This will be capable of launching and returning a 10,000 pound payload to a 100 nautical mile polar orbit using low-risk technology. The vehicle, Beta 2, is a derivative of the USAF/Boeing Beta vehicle which was designed to deliver a 50,000 pound payload to a similar orbit. Beta 2 stages at Mach 6.5 and about 100,000 ft altitude. The propulsion system for the booster is an over/under turbine bypass engine/ramjet configuration. In this paper, several options for thrust augmentation were studied in order to improve the performance of this engine where there was a critical need. Options studies were turbine engine overspeed in the transonic region, water injection at a various turbine engine locations also during the transonic region, and water injection at the turbine engine face during high speed operation. The methodology, constraints, propulsion performance, and mission study results are presented.

  15. A two-stage magnetic refrigerator for astronomical applications with reservoir temperatures above 4 K

    NASA Technical Reports Server (NTRS)

    Hagmann, C.; Richards, P. L.

    1993-01-01

    We propose a novel adiabatic demagnetization refrigerator (ADR) to produce temperatures as low as 100 mK starting from a high temperature reservoir between 4 and 8 K. The high temperature reservoir for the ADR can be provided by a mechanical cooler or an unpumped liquid helium bath. This refrigerator can be used to cool bolometric infrared detectors for low background astronomy from mountain tops, balloons or satellites as well as to cool cryogenic x-ray detectors. The two-stage ADR consists of a single magnet with a paramagnetic chromic-cesium-alum (CCA) salt pill to produce the low temperature and paramagnetic gadolinium-gallium-garnet (GGG) as the first stage to intercept heat from the high temperature reservoir. Thermal contact between the paramagnets and the reservoir during magnetization is made with a mechanical heat switch. The ADR is suspended with Kevlar chords under tension for high mechanical stiffness and low parasitic heat leak. In a single cycle, the ADR maintains a temperature of 100 mK for 10 to 100 hours. This time depends strongly on the magnetic field and reservoir temperature but not on the volume of the paramagnetic material as long as the heat leak is dominated by the suspension.

  16. A Two-Stage Framework for 3D Face Reconstruction from RGBD Images.

    PubMed

    Wang, Kangkan; Wang, Xianwang; Pan, Zhigeng; Liu, Kai

    2014-08-01

    This paper proposes a new approach for 3D face reconstruction with RGBD images from an inexpensive commodity sensor. The challenges we face are: 1) substantial random noise and corruption are present in low-resolution depth maps; and 2) there is high degree of variability in pose and face expression. We develop a novel two-stage algorithm that effectively maps low-quality depth maps to realistic face models. Each stage is targeted toward a certain type of noise. The first stage extracts sparse errors from depth patches through the data-driven local sparse coding, while the second stage smooths noise on the boundaries between patches and reconstructs the global shape by combining local shapes using our template-based surface refinement. Our approach does not require any markers or user interaction. We perform quantitative and qualitative evaluations on both synthetic and real test sets. Experimental results show that the proposed approach is able to produce high-resolution 3D face models with high accuracy, even if inputs are of low quality, and have large variations in viewpoint and face expression.

  17. Performance of an innovative two-stage process converting food waste to hydrogen and methane.

    PubMed

    Han, Sun-Kee; Shin, Hang-Sik

    2004-02-01

    This study was conducted to evaluate the performance of an innovative two-stage process, BIOCELL, that was developed to produce hydrogen (H2) and methane (CH4) from food waste on the basis of phase separation, reactor rotation mode, and sequential batch technique. The BIOCELL process consisted of four leaching-bed reactors for H2 recovery and post-treatment and a UASB reactor for CH4 recovery. The leaching-bed reactors were operated in a rotation mode with a 2-day interval between degradation stages. The sequential batch technique was useful to optimize environmental conditions during H2 fermentation. The BIOCELL process demonstrated that, at the high volatile solids (VS) loading rate of 11.9 kg/m3 x day, it could remove 72.5% of VS and convert VS(removed) to H2 (28.2%) and CH4 (69.9%) on a chemical oxygen demand (COD) basis in 8 days. H2 gas production rate was 3.63 m3/m3 x day, while CH4 gas production rate was 1.75 m3/m3 x day. The yield values of H2 and CH4 were 0.31 and 0.21 m3/kg VS(added), respectively. Moreover, the output from the post-treatment could be used as a soil amendment. The BIOCELL process proved to be stable, reliable, and effective in resource recovery as well as waste stabilization.

  18. Two-stage fungal pre-treatment for improved biogas production from sisal leaf decortication residues.

    PubMed

    Muthangya, Mutemi; Mshandete, Anthony Manoni; Kivaisi, Amelia Kajumulo

    2009-11-06

    Sisal leaf decortications residue (SLDR) is amongst the most abundant agro-industrial residues in Tanzania and is a good feedstock for biogas production. Pre-treatment of the residue prior to its anaerobic digestion (AD) was investigated using a two-stage pre-treatment approach with two fungal strains, CCHT-1 and Trichoderma reesei in succession in anaerobic batch bioreactors. AD of the pre-treated residue with CCTH-1 at 10% (wet weight inoculum/SLDR) inoculum concentration incubated for four days followed by incubation for eight days with 25% (wet weight inoculum/SLDR) of T. reesei gave a methane yield of 0.292 +/- 0.04 m(3) CH(4)/kg volatile solids (VS)(added). On reversing the pre-treatment succession of the fungal inocula using the same parameters followed by AD, methane yield decreased by about 55%. Generally, an increment in the range of 30-101% in methane yield in comparison to the un-treated SLDR was obtained. The results confirmed the potential of CCHT-1 followed by Trichoderma reesei fungi pre-treatment prior to AD to achieve significant improvement in biogas production from SLDR.

  19. Two-Stage Screening for Math Problem-Solving Difficulty Using Dynamic Assessment of Algebraic Learning

    PubMed Central

    Fuchs, Lynn S.; Compton, Donald L.; Fuchs, Douglas; Hollenbeck, Kurstin N.; Hamlett, Carol L.; Seethaler, Pamela M.

    2011-01-01

    The purpose of this study was to explore the utility of a dynamic assessment (DA) of algebraic learning in predicting third graders’ development of mathematics word-problem difficulty. In the fall, 122 third-grade students were assessed on a test of math word-problem skill and DA of algebraic learning. In the spring, they were assessed on word-problem performance. Logistic regression was conducted to contrast two models. One relied exclusively on the fall test of math word-problem skill to predict word-problem difficulty on the spring outcome (less than the 25th percentile). The second model relied on a combination of the fall test of math word-problem skill and the fall DA to predict the same outcome. Holding sensitivity at 87.5%, the universal screener alone resulted in a high proportion of false positives, which was practically reduced when DA was included in the prediction model. Findings are discussed in terms of a two-stage process for screening students within a responsiveness-to-intervention prevention model. PMID:21685352

  20. Two stages in neurite formation distinguished by differences in tubulin metabolism.

    PubMed

    Sekimoto, S; Tashiro, T; Komiya, Y

    1995-01-01

    Changes in tubulin solubility during neurite formation were studied biochemically using rat dorsal root ganglion neurons in culture. When fractionated with Ca(2+)-containing buffer at low temperature, a considerable proportion of total cellular tubulin was recovered in the insoluble fraction. We designated this cold/Ca(2+)-insoluble tubulin (InsT) and distinguished it from cold/Ca(2+)-soluble tubulin (SoIT). From the relative amount of InsT, neurite formation was found to proceed through two distinct stages. The first 6 days after plating (stage 1) in which the proportion of InsT increased dramatically (from 5 to 60%) coincided with neurite outgrowth. In the following period (stage 2), a constant level of InsT was maintained, whereas neurite maturation took place. Pulse-labeling experiments further revealed that the two stages differed significantly in terms of tubulin metabolism. High rates of synthesis as well as conversion from SoIT to InsT were observed in stage 1, whereas stage 2 was characterized by a decrease in both of these rates and an increase in the rate of degradation. The results show for the first time the coordinated changes in tubulin metabolism that underlie the process of neurite formation. PMID:7798932

  1. Beyond two-stage models for lung carcinogenesis in the Mayak workers: implications for plutonium risk.

    PubMed

    Zöllner, Sascha; Sokolnikov, Mikhail E; Eidemüller, Markus

    2015-01-01

    Mechanistic multi-stage models are used to analyze lung-cancer mortality after Plutonium exposure in the Mayak-workers cohort, with follow-up until 2008. Besides the established two-stage model with clonal expansion, models with three mutation stages as well as a model with two distinct pathways to cancer are studied. The results suggest that three-stage models offer an improved description of the data. The best-fitting models point to a mechanism where radiation increases the rate of clonal expansion. This is interpreted in terms of changes in cell-cycle control mediated by bystander signaling or repopulation following cell killing. No statistical evidence for a two-pathway model is found. To elucidate the implications of the different models for radiation risk, several exposure scenarios are studied. Models with a radiation effect at an early stage show a delayed response and a pronounced drop-off with older ages at exposure. Moreover, the dose-response relationship is strongly nonlinear for all three-stage models, revealing a marked increase above a critical dose.

  2. Parameter estimation for metabolic networks with two stage Bregman regularization homotopy inversion algorithm.

    PubMed

    Wang, Hong; Wang, Xi-cheng

    2014-02-21

    Metabolism is a very important cellular process and its malfunction contributes to human disease. Therefore, building dynamic models for metabolic networks with experimental data in order to analyze biological process rationally has attracted a lot of attention. Owing to the technical limitations, some unknown parameters contained in models need to be estimated effectively by means of the computational method. Generally, problems of parameter estimation of nonlinear biological network are known to be ill condition and multimodal. In particular, with the increasing amount and enlarging the scope of parameters, many optimization algorithms often fail to find a global solution. In this paper, two-stage variable factor Bregman regularization homotopy method is proposed. Discrete homotopy is used to identify the possible extreme region and continuous homotopy is executed for the purpose of stability of path tracing in the special region. Meanwhile, Latin hypercube sampling is introduced to get the good initial guess value and a perturbation strategy is developed to jump out of the local optimum. Three metabolic network inverse problems are investigated to demonstrate the effectiveness of the proposed method. PMID:24060619

  3. Two-stage liver transplantation: an effective procedure in urgent conditions.

    PubMed

    Montalti, Roberto; Busani, Stefano; Masetti, Michele; Girardis, Massimo; Di Benedetto, Fabrizio; Begliomini, Bruno; Rompianesi, Gianluca; Rinaldi, Laura; Ballarin, Roberto; Pasetto, Alberto; Gerunda, Giorgio E

    2010-01-01

    Temporary portocaval shunt and total hepatectomy is a technique used in the presence of toxic liver syndrome because of fulminant hepatic failure, hepatic trauma, primary non-function (PNF), and eclampsia. We performed this technique on four patients. An indication for anhepatic state was severe hemodynamic instability in three of them. Etiologies of these three patients were as follows: PNF after liver transplantation, ischemic hepatitis after right hepatic artery embolization, and massive reperfusion syndrome during a liver transplantation. In the fourth patient, during the liver transplantation when hepatic artery was ligated, a kidney carcinoma in the donor graft was discovered. We decided to complete the hepatectomy and to construct a temporary portocaval shunt. Mean anhepatic phases were 19 h and 15 min. All patients survived the two-stage liver transplantation procedure without major complications. Our cases demonstrated that temporary portocaval shunt while awaiting urgent liver transplantation could be an effective "bridge" in selected patients who develop toxic liver syndrome; however, a short time between portocaval shunt and transplantation and careful intensive care managements are mandatory.

  4. Food Behavior Change in Late-Life Widowhood: A Two-Stage Process

    PubMed Central

    Vesnaver, Elisabeth; Keller, Heather H.; Sutherland, Olga; Maitland, Scott B.; Locher, Julie L.

    2015-01-01

    Widowhood is a common life event for married older women. Prior research has found disruptions in eating behaviors to be common among widows. Little is known about the process underlying these disruptions. The aim of this study was to generate a theoretical understanding of the changing food behaviors of older women during the transition of widowhood. Qualitative methods based on constructivist grounded theory guided by a critical realist worldview were used. Individual active interviews were conducted with 15 community-living women, aged 71 to 86 years, living alone, and widowed six months to 15 years at the time of the interview. Participants described a variety of educational backgrounds and levels of health, were mainly white and of Canadian or European descent, and reported sufficient income to meet their needs. The loss of regular shared meals initiated a two-stage process whereby women first fall into new patterns and then re-establish the personal food system, thus enabling women to redirect their food system from one that satisfied the couple to one that satisfied their personal food needs. Influences on the trajectory of the change process included the couple’s food system, experience with nutritional care, food-related values, and food-related resources. Implications for research and practice are discussed. PMID:26232138

  5. Contextual Classification of Point Clouds Using a Two-Stage Crf

    NASA Astrophysics Data System (ADS)

    Niemeyer, J.; Rottensteiner, F.; Soergel, U.; Heipke, C.

    2015-03-01

    In this investigation, we address the task of airborne LiDAR point cloud labelling for urban areas by presenting a contextual classification methodology based on a Conditional Random Field (CRF). A two-stage CRF is set up: in a first step, a point-based CRF is applied. The resulting labellings are then used to generate a segmentation of the classified points using a Conditional Euclidean Clustering algorithm. This algorithm combines neighbouring points with the same object label into one segment. The second step comprises the classification of these segments, again with a CRF. As the number of the segments is much smaller than the number of points, it is computationally feasible to integrate long range interactions into this framework. Additionally, two different types of interactions are introduced: one for the local neighbourhood and another one operating on a coarser scale. This paper presents the entire processing chain. We show preliminary results achieved using the Vaihingen LiDAR dataset from the ISPRS Benchmark on Urban Classification and 3D Reconstruction, which consists of three test areas characterised by different and challenging conditions. The utilised classification features are described, and the advantages and remaining problems of our approach are discussed. We also compare our results to those generated by a point-based classification and show that a slight improvement is obtained with this first implementation.

  6. Treatment of Ammonia Nitrogen Wastewater in Low Concentration by Two-Stage Ozonization

    PubMed Central

    Luo, Xianping; Yan, Qun; Wang, Chunying; Luo, Caigui; Zhou, Nana; Jian, Chensheng

    2015-01-01

    Ammonia nitrogen wastewater (about 100 mg/L) was treated by two-stage ozone oxidation method. The effects of ozone flow rate and initial pH on ammonia removal were studied, and the mechanism of ammonia nitrogen removal by ozone oxidation was discussed. After the primary stage of ozone oxidation, the ammonia removal efficiency reached 59.32% and pH decreased to 6.63 under conditions of 1 L/min ozone flow rate and initial pH 11. Then, the removal efficiency could be over 85% (the left ammonia concentration was lower than 15 mg/L) after the second stage, which means the wastewater could have met the national discharge standards of China. Besides, the mechanism of ammonia removal by ozone oxidation was proposed by detecting the products of the oxidation: ozone oxidation directly and ·OH oxidation; ammonia was mainly transformed into NO3−-N, less into NO2−-N, not into N2. PMID:26404353

  7. Ecotoxicity of materials from integrated two-stage liquefaction and Exxon Donor Solvent processes

    SciTech Connect

    Dauble, D.D.; Scott, A.J.; Lusty, E.W.; Thomas, B.L.; Hanf, R.W. Jr.

    1983-05-01

    Coal-derived materials from two coal conversion processes were screened for potential ecological toxicity. We examined the toxicity of materials from different engineering or process options to an aquatic invertebrate and also related potential hazard to relative concentration, composition, and stability of water soluble components. For materials tested from the Integrated Two-Stage Liquefaction (ITSL) process, only the LC finer (LCF) 650/sup 0/F distillate was highly soluble in water at 20/sup 0/C. The LCF feed and Total Liquid Product (TLP) were not in liquid state at 20/sup 0/C and were relatively insoluble in water. Relative hazard to daphnids from ITSL materials was as follows: LCF 650/sup 0/F distillate greater than or equal to LCF feed greater than or equal to TLP. For Exxon Donor Solvent (EDS) materials, process solvent produced in the bottoms recycle mode was more soluble in water than once-through process solvent and, hence, slightly more acutely toxic to daphnids. When compared to other coal liquids or petroleum products, the ITSL or EDS liquids were intermediate in toxicity; relative hazard ranged from 1/7 to 1/13 of the Solvent Refined Coal (SRC)-II distillable blend, but was several times greater than the relative hazard for No. 2 diesel fuel oil or Prudhoe Bay crude oil. Although compositonal differences in water-soluble fractions (WSF) were noted among materials, phenolics were the major compound class in all WSFs and probably the primary contributor to acute toxicity.

  8. Two-stage high resolution remote sensing image retrieval combining semantic and visual features

    NASA Astrophysics Data System (ADS)

    Wan, Qi-Ming; Wang, Min; Zhang, Xing-Yue; Zhang, Da-Qian

    2009-10-01

    In this work, we put forward a two-stage image retrieval methodology by integrating high level image semantic features and low level visual features. At the first stage, we segment an image into parcels using a multiresolution remotely sensed image segmentation method combining rainfalling watershed algorithm and fast region merging. We then classify these parcels with Support Vector Machine (SVM), a famous non-linear classification scheme to connect the low-level visual features with high-level semantic features. These classes are then stored in semantic features databases for future use. When users carry out their rough semantic retrieval, they should choose and combine these semantic classes, and our method returns some image blocks which include the interested classes as the first "rough" retrieval results. At the second stage users should select an example from the results. We then construct and compare the similarity between the color and texture histograms for both the query example and each one in the semantic retrieval result. If the total similarity is higher than some threshold, the image will be returned as a suitable retrieval result. These images are sorted according their similarity as the final retrieval results. Experiments indicate our approach can get more effective and accurate results than content-based image retrieval only using visual features.

  9. Two stage enucleation and deflation of a large unicystic ameloblastoma with mural invasion in mandible.

    PubMed

    Sasaki, Ryo; Watanabe, Yorikatsu; Ando, Tomohiro; Akizuki, Tanetaka

    2014-06-01

    A treatment for strategy of unicystic ameloblastoma (UA) should be decided by its pathology type including luminal or mural type. Luminal type of UA can be treated only by enucleation alone, but UA with mural invasion should be treated aggressively like conventional ameloblastomas. However, it is difficult to diagnose the subtype of UA by an initial biopsy. There is a possibility that the lesion is an ordinary cyst or keratocystic odontogenic tumor, leading to a possible overtreatment. Therefore, this study performed the enucleation of the cyst wall and deflation at first, and the pathological finding confirmed mural invasion into the cystic wall, leading to the second surgery. The second surgery enucleated scar tissue, bone curettage, and deflation, and was able to contribute to the reduction of the recurrence rate by removing tumor nest in scar tissue or new bone, enhancing new bone formation, and shrinking the mandibular expanding by fenestration. In this study, a large UA with mural invasion including condyle was treated by "two-stage enucleation and deflation" in a 20-year-old patient.

  10. Two-Stage Deformation of Olivine Aggregates with Changing Deformation Kinematics

    NASA Astrophysics Data System (ADS)

    Mahan, B. M.; Skemer, P. A.; Griera, A.

    2011-12-01

    Two-stage deformation experiments have been conducted on synthetic olivine aggregates to investigate the influence of pre-existing fabric on the evolution of lattice-preferred orientation (LPO), seismic anisotropy, and grain morphology. This study is motivated by recent work on naturally and experimentally deformed peridotites, which suggest that the alignment of olivine axes with the shear plane requires more strain in samples with a strong pre-existing LPO than in samples with weak or random LPO. In the first stage of deformation, aggregates synthesized from San Carlos olivine are deformed at P = 1 GPa and T = 1500 K in a triaxial geometry to produce axi-symmetric LPOs of varying strength. In a second stage of deformation, the aggregates are re-deformed in simple shear to varying shear strains. Microstructural analyses are performed after each step (synthesis, triaxial deformation, simple shear deformation) using optical microscopy and electron backscatter diffraction (EBSD). These results are compared to numerical models of microstructural evolution. Our results provide constraints on the evolution of LPO and consequent seismic signature as a function of preexisting rock fabric. These data are necessary to interpret seismic anisotropy in settings where kinematics are complex, such as mid-ocean ridges and subduction zones.

  11. Improved two-stage equalization for coherent Pol-Mux QPSK and 16-QAM systems.

    PubMed

    Zhu, Chen; Tran, An V; Chen, Simin; Du, Liang B; Anderson, Trevor; Lowery, Arthur J; Skafidas, Efstratios

    2012-12-10

    We report a two-stage blind frequency domain equalization method for long-haul coherent polarization-multiplexed (pol-mux) systems using quadrature phase shift keying (QPSK) and 16-quadrature amplitude modulation (16-QAM). In the first stage, blind CD parameter prediction is conducted prior to a CD equalizer. This supports flexible path switching in optical networks. In the second stage, a frequency-domain multi-modulus algorithm (MMA) equalizer is used to cope with the residual fiber impairments and perform polarization de-multiplexing. Compared with the conventional constant modulus algorithm (CMA), MMA shows advantages including better steady state performance and a faster convergence rate. Furthermore, all the estimation and equalization algorithms are implemented in the frequency domain which potentially provides the least complexity for the pol-mux optical coherent systems. The proposed algorithm is experimentally demonstrated with an 800-km 10 Gbaud coherent optical pol-mux system. For QPSK signal, the proposed method achieves error-free transmission and shows superior convergence speed against CMA, and for 16-QAM signals, the proposed MMA outperforms CMA with more than 1-dB improvement in Q-value.

  12. Study on the Effect of Mutated Bacillus Megaterium in Two-Stage Fermentation of Vitamin C

    NASA Astrophysics Data System (ADS)

    Lü, Shujuan; Wang, Jun; Yao, Jianming; Yu, Zengliang

    2003-10-01

    Bacillus megaterium as a companion strain in two-stage fermentation of vitamin C could secrete some active substances to spur growth of Gluconobacter oxydans to produce 2-KLG. In the fermenting system where Gluconobacter oxydans was combined with GB82-a mutated strain of B. megaterium by ion implantation, the amount of 2-KLG harvested was larger than that produced by the original B. megaterium BP52 [1] being substituted for GB82. In this paper, we studied the effect of the active substances secreted by GB82 to enhance the capability of Gluconobacter oxydans to produce 2-KLG. The supernate of GB82 sampled at different cultivation times all had much more activity to spur Gluconobacter oxydans to yield 2-KLG than that of the original B. megaterium, which might be due to the genetic changes in the active components caused by ion implantation. Furthermore, the active substances of GB82's supernate would lose a part of its activity in extreme environments, which is typical of some proteins.

  13. A two-stage storage routing model for green roof runoff detention.

    PubMed

    Vesuviano, Gianni; Sonnenwald, Fred; Stovin, Virginia

    2014-01-01

    Green roofs have been adopted in urban drainage systems to control the total quantity and volumetric flow rate of runoff. Modern green roof designs are multi-layered, their main components being vegetation, substrate and, in almost all cases, a separate drainage layer. Most current hydrological models of green roofs combine the modelling of the separate layers into a single process; these models have limited predictive capability for roofs not sharing the same design. An adaptable, generic, two-stage model for a system consisting of a granular substrate over a hard plastic 'egg box'-style drainage layer and fibrous protection mat is presented. The substrate and drainage layer/protection mat are modelled separately by previously verified sub-models. Controlled storm events are applied to a green roof system in a rainfall simulator. The time-series modelled runoff is compared to the monitored runoff for each storm event. The modelled runoff profiles are accurate (mean Rt(2) = 0.971), but further characterization of the substrate component is required for the model to be generically applicable to other roof configurations with different substrate. PMID:24647183

  14. Experimental and numerical evaluation of the performance of supersonic two-stage high-velocity oxy-fuel thermal spray (Warm Spray) gun

    NASA Astrophysics Data System (ADS)

    Katanoda, H.; Morita, H.; Komatsu, M.; Kuroda, S.

    2011-03-01

    The water-cooled supersonic two-stage high-velocity oxy-fuel (HVOF) thermal spray gun was developed to make a coating of temperature-sensitive material, such as titanium, on a substrate. The gun has a combustion chamber (CC) followed by a mixing chamber (MC), in which the combustion gas is mixed with the nitrogen gas at room temperature. The mixed gas is accelerated to supersonic speed through a converging-diverging (C-D) nozzle followed by a straight passage called the barrel. This paper proposes an experimental procedure to estimate the cooling rate of CC, MC and barrel separately. Then, the mathematical model is presented to predict the pressure and temperature in the MC for the specific mass flow rates of fuel, oxygen and nitrogen by assuming chemical equilibrium with water-cooling in the CC and MC, and frozen flow with constant specific heat from stagnant condition to the throat in the CC and MC. Finally, the present mathematical model was validated by comparing the calculated and measured stagnant pressures of the CC of the two-stage HVOF gun.

  15. Engineered cell-free scaffold with two-stage delivery of miRNA-26a for bone repair

    PubMed Central

    Paquet, Joseph; Moya, Adrien; Bensidhoum, Morad

    2016-01-01

    The treatment of non-unions and bone defects is a major challenge. In these situations, autologous bone is the preferred treatment but has several serious limitations. Treatment alternatives including the use of calcium-based scaffolds alone or associated with either growth factors or stem cells have therefore been developed, or are under development, to overcome these shortcomings. Each of these are, however, associated with their own drawbacks, such as the lack of sustained/controlled delivery system for growth factors and poor cell survival and engraftment for stem cells. MicroRNAs (miRNAs), a class of small noncoding RNAs fine-tune the expression of as much as 30% of all mammalian protein-encoding genes. For instance, miRNA26a is able to promote the repair of critical-size calvarial bone defects. Yet, the clinical application of these fascinating molecules has been hampered by a lack of appropriate delivery systems. In an elegant report entitled cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects, Zhang et al. 2016, developped a non-viral vector with high affinity to miR-26a that ensured its efficient delivery in bone defects. Engineered scaffolds were able to induce the regeneration of calvarial bone defects in healthy and osteoporotic mice. Taken together, these data pave the way for the development of advanced bone substitutes that at least will match, and preferably supersede, the clinical efficiency of autologous bone grafts. However, the transfer from the bench to the bedside of such scaffolds requires further investigations including (I) a better understanding of the underlying biological mechanisms involved in bone formation via miRNA26a; (II) evidences of polymer scaffold biocompatibility upon its complete degradation; and (III) demonstration of the engineered scaffold functionality in defects of clinically relevant volume. PMID:27294100

  16. Effects of combined lipoic acid and pyridoxine on albuminuria, advanced glycation end-products, and blood pressure in diabetic nephropathy.

    PubMed

    Noori, Nazanin; Tabibi, Hadi; Hosseinpanah, Farhad; Hedayati, Mehdi; Nafar, Mohsen

    2013-01-01

    This study was designed to investigate the effects of combined administration of lipoic acid and pyridoxine on albuminuria, oxidative stress, blood pressure, serum advanced glycation end-products, nitric oxide (NO), and endothelin-1 in patients with diabetic nephropathy. Thirty-four patients were randomly assigned to either a supplement group or a placebo group. The patients in the supplement group received 800 mg lipoic acid and 80 mg pyridoxine daily for 12 weeks, whereas the placebo group received corresponding placebos. Urinary albumin, serum malondialdehyde (MDA), and systolic blood pressure decreased significantly in the supplement group compared to the placebo group (p < 0.05). Serum NO increased in the supplement group compared to the placebo group (p < 0.05). Serum pentosidine and carboxymethyl lysine decreased significantly in the supplement group at the end of week 12 compared to baseline (p < 0.05). No statistically significant differences were observed between the two groups in mean changes of serum endothelin-1, glucose, and diastolic blood pressure. The present study indicates that combined administration of lipoic acid and pyridoxine improves albuminuria in patients with diabetic nephropathy by reducing oxidative stress, advanced glycation end-products, and systolic blood pressure. The reduction in microalbuminuria may be of benefit in retarding the progression of diabetic nephropathy.

  17. THE SCALE-UP OF LARGE PRESSURIZED FLUIDIZED BEDS FOR ADVANCED COAL FIRED PROCESSES

    SciTech Connect

    Leon Glicksman; Hesham Younis; Richard Hing-Fung Tan; Michel Louge; Elizabeth Griffith; Vincent Bricout

    1998-04-30

    Pressurized fluidization is a promising new technology for the clean and efficient combustion of coal. Its principle is to operate a coal combustor at high inlet gas velocity to increase the flow of reactants, at an elevated pressure to raise the overall efficiency of the process. Unfortunately, commercialization of large pressurized fluidized beds is inhibited by uncertainties in scaling up units from the current pilot plant levels. In this context, our objective is to conduct a study of the fluid dynamics and solid capture of a large pressurized coal-fired unit. The idea is to employ dimensional similitude to simulate in a cold laboratory model the flow in a Pressurized Circulating Fluid Bed ''Pyrolyzer,'' which is part of a High Performance Power System (HIPPS) developed by Foster Wheeler Development Corporation (FWDC) under the DOE's Combustion 2000 program.

  18. Two-Stage Magma Mixing and Initial Phase of the 1667 Plinian Eruption of Tarumai Volcano

    NASA Astrophysics Data System (ADS)

    Tomiya, A.; Takeuchi, S.

    2009-12-01

    25, Mg/Mn > 10 (type-3) with no type-1 (classification based on Nakagawa et al. (2006)); magnetite inclusions in pyroxene phenocrysts in b8-bottom are, however, type-1. According to the observations, we propose two-stage magma mixing as follows. Prior to the 1667 eruption, there are high-T mafic magma with olivine, calcic plagioclase and type-3 magnetite, and low-T main magma with two pyroxenes, other types of plagioclase and type-1 magnetite (and few ilmenite). The first-stage mixing between the two magmas formed the precursory hybrid magma, but could not prompt the magma to erupt immediately. In the hybrid magma, type-1 and -3 magnetite rehomogenized into type-2 due to rapid cation diffusion, but magnetite inclusions in pyroxene remained type-1. Then, the second-stage mixing between the hybrid magma and the high-T magma occurred, and just after the mixing (with no rehomogenization of type-3 magnetite) the eruption began. Following the hybrid magma (b8-bottom), the main magma erupted. Considering the diffusion coefficients of Ti and Mg in magnetite, the period between the two mixings was several years, whereas the period between the second mixing and the eruption was less than weeks. The two-stage mixing of high-T magma enabled the high-viscosity phenocryst-rich magma to erupt.

  19. A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis

    PubMed Central

    Chiò, Adriano; Schymick, Jennifer C.; Restagno, Gabriella; Scholz, Sonja W.; Lombardo, Federica; Lai, Shiao-Lin; Mora, Gabriele; Fung, Hon-Chung; Britton, Angela; Arepalli, Sampath; Gibbs, J. Raphael; Nalls, Michael; Berger, Stephen; Kwee, Lydia Coulter; Oddone, Eugene Z.; Ding, Jinhui; Crews, Cynthia; Rafferty, Ian; Washecka, Nicole; Hernandez, Dena; Ferrucci, Luigi; Bandinelli, Stefania; Guralnik, Jack; Macciardi, Fabio; Torri, Federica; Lupoli, Sara; Chanock, Stephen J.; Thomas, Gilles; Hunter, David J.; Gieger, Christian; Wichmann, H. Erich; Calvo, Andrea; Mutani, Roberto; Battistini, Stefania; Giannini, Fabio; Caponnetto, Claudia; Mancardi, Giovanni Luigi; La Bella, Vincenzo; Valentino, Francesca; Monsurrò, Maria Rosaria; Tedeschi, Gioacchino; Marinou, Kalliopi; Sabatelli, Mario; Conte, Amelia; Mandrioli, Jessica; Sola, Patrizia; Salvi, Fabrizio; Bartolomei, Ilaria; Siciliano, Gabriele; Carlesi, Cecilia; Orrell, Richard W.; Talbot, Kevin; Simmons, Zachary; Connor, James; Pioro, Erik P.; Dunkley, Travis; Stephan, Dietrich A.; Kasperaviciute, Dalia; Fisher, Elizabeth M.; Jabonka, Sibylle; Sendtner, Michael; Beck, Marcus; Bruijn, Lucie; Rothstein, Jeffrey; Schmidt, Silke; Singleton, Andrew; Hardy, John; Traynor, Bryan J.

    2009-01-01

    The cause of sporadic amyotrophic lateral sclerosis (ALS) is largely unknown, but genetic factors are thought to play a significant role in determining susceptibility to motor neuron degeneration. To identify genetic variants altering risk of ALS, we undertook a two-stage genome-wide association study (GWAS): we followed our initial GWAS of 545 066 SNPs in 553 individuals with ALS and 2338 controls by testing the 7600 most associated SNPs from the first stage in three independent cohorts consisting of 2160 cases and 3008 controls. None of the SNPs selected for replication exceeded the Bonferroni threshold for significance. The two most significantly associated SNPs, rs2708909 and rs2708851 [odds ratio (OR) = 1.17 and 1.18, and P-values = 6.98 × 10−7 and 1.16 × 10−6], were located on chromosome 7p13.3 within a 175 kb linkage disequilibrium block containing the SUNC1, HUS1 and C7orf57 genes. These associations did not achieve genome-wide significance in the original cohort and failed to replicate in an additional independent cohort of 989 US cases and 327 controls (OR = 1.18 and 1.19, P-values = 0.08 and 0.06, respectively). Thus, we chose to cautiously interpret our data as hypothesis-generating requiring additional confirmation, especially as all previously reported loci for ALS have failed to replicate successfully. Indeed, the three loci (FGGY, ITPR2 and DPP6) identified in previous GWAS of sporadic ALS were not significantly associated with disease in our study. Our findings suggest that ALS is more genetically and clinically heterogeneous than previously recognized. Genotype data from our study have been made available online to facilitate such future endeavors. PMID:19193627

  20. A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.

    PubMed

    Chiò, Adriano; Schymick, Jennifer C; Restagno, Gabriella; Scholz, Sonja W; Lombardo, Federica; Lai, Shiao-Lin; Mora, Gabriele; Fung, Hon-Chung; Britton, Angela; Arepalli, Sampath; Gibbs, J Raphael; Nalls, Michael; Berger, Stephen; Kwee, Lydia Coulter; Oddone, Eugene Z; Ding, Jinhui; Crews, Cynthia; Rafferty, Ian; Washecka, Nicole; Hernandez, Dena; Ferrucci, Luigi; Bandinelli, Stefania; Guralnik, Jack; Macciardi, Fabio; Torri, Federica; Lupoli, Sara; Chanock, Stephen J; Thomas, Gilles; Hunter, David J; Gieger, Christian; Wichmann, H Erich; Calvo, Andrea; Mutani, Roberto; Battistini, Stefania; Giannini, Fabio; Caponnetto, Claudia; Mancardi, Giovanni Luigi; La Bella, Vincenzo; Valentino, Francesca; Monsurrò, Maria Rosaria; Tedeschi, Gioacchino; Marinou, Kalliopi; Sabatelli, Mario; Conte, Amelia; Mandrioli, Jessica; Sola, Patrizia; Salvi, Fabrizio; Bartolomei, Ilaria; Siciliano, Gabriele; Carlesi, Cecilia; Orrell, Richard W; Talbot, Kevin; Simmons, Zachary; Connor, James; Pioro, Erik P; Dunkley, Travis; Stephan, Dietrich A; Kasperaviciute, Dalia; Fisher, Elizabeth M; Jabonka, Sibylle; Sendtner, Michael; Beck, Marcus; Bruijn, Lucie; Rothstein, Jeffrey; Schmidt, Silke; Singleton, Andrew; Hardy, John; Traynor, Bryan J

    2009-04-15

    The cause of sporadic amyotrophic lateral sclerosis (ALS) is largely unknown, but genetic factors are thought to play a significant role in determining susceptibility to motor neuron degeneration. To identify genetic variants altering risk of ALS, we undertook a two-stage genome-wide association study (GWAS): we followed our initial GWAS of 545 066 SNPs in 553 individuals with ALS and 2338 controls by testing the 7600 most associated SNPs from the first stage in three independent cohorts consisting of 2160 cases and 3008 controls. None of the SNPs selected for replication exceeded the Bonferroni threshold for significance. The two most significantly associated SNPs, rs2708909 and rs2708851 [odds ratio (OR) = 1.17 and 1.18, and P-values = 6.98 x 10(-7) and 1.16 x 10(-6)], were located on chromosome 7p13.3 within a 175 kb linkage disequilibrium block containing the SUNC1, HUS1 and C7orf57 genes. These associations did not achieve genome-wide significance in the original cohort and failed to replicate in an additional independent cohort of 989 US cases and 327 controls (OR = 1.18 and 1.19, P-values = 0.08 and 0.06, respectively). Thus, we chose to cautiously interpret our data as hypothesis-generating requiring additional confirmation, especially as all previously reported loci for ALS have failed to replicate successfully. Indeed, the three loci (FGGY, ITPR2 and DPP6) identified in previous GWAS of sporadic ALS were not significantly associated with disease in our study. Our findings suggest that ALS is more genetically and clinically heterogeneous than previously recognized. Genotype data from our study have been made available online to facilitate such future endeavors. PMID:19193627

  1. The influence of Thomson effect in the performance optimization of a two stage thermoelectric cooler

    NASA Astrophysics Data System (ADS)

    Kaushik, S. C.; Manikandan, S.

    2015-12-01

    The exoreversible and irreversible thermodynamic models of a two stage thermoelectric cooler (TTEC) considering Thomson effect in conjunction with Peltier, Joule and Fourier heat conduction effects have been investigated using exergy analysis. New expressions for the interstage temperature, optimum current for the maximum cooling power, energy and exergy efficiency conditions, energy efficiency and exergy efficiency of a TTEC are derived as well. The number of thermocouples in the first and second stages of a TTEC for the maximum cooling power, energy and exergy efficiency conditions are optimized. The results show that the exergy efficiency is lower than the energy efficiency e.g., in an irreversible TTEC with total 30 thermocouples, heat sink temperature (TH) of 300 K and heat source temperature (TC) of 280 K, the obtained maximum cooling power, maximum energy and exergy efficiency are 20.37 W, 0.7147 and 5.10% respectively. It has been found that the Thomson effect increases the cooling power and energy efficiency of the TTEC system e.g., in the exoreversible TTEC the cooling power and energy efficiency increased from 14.87 W to 16.36 W and from 0.4079 to 0.4998 respectively for ΔTC of 40 K when Thomson effect is considered. It has also been found that the heat transfer area at the hot side of an irreversible TTEC should be higher than the cold side for maximum performance operation. This study will help in the designing of the actual multistage thermoelectric cooling systems.

  2. Conceptual design of two-stage-to-orbit hybrid launch vehicle

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The object of this design class was to design an earth-to orbit vehicle to replace the present NASA space shuttle. The major motivations for designing a new vehicle were to reduce the cost of putting payloads into orbit and to design a vehicle that could better service the space station with a faster turn-around time. Another factor considered in the design was that near-term technology was to be used. Materials, engines and other important technologies were to be realized in the next 10 to 15 years. The first concept put forth by NASA to meet these objectives was the National Aerospace Plane (NASP). The NASP is a single-stage earth-to-orbit air-breathing vehicle. This concept ran into problems with the air-breathing engine providing enough thrust in the upper atmosphere, among other things. The solution of this design class is a two-stage-to-orbit vehicle. The first stage is air-breathing and the second stage is rocket-powered, similar to the space shuttle. The second stage is mounted on the top of the first stage in a piggy-back style. The vehicle takes off horizontally using only air-breathing engines, flies to Mach six at 100,000 feet, and launches the second stage towards its orbital path. The first stage, or booster, will weigh approximately 800,000 pounds and the second stage, or orbiter will weigh approximately 300,000 pounds. The major advantage of this design is the full recoverability of the first stage compared with the present solid rocket booster that are only partially recoverable and used only a few times. This reduces the cost as well as providing a more reliable and more readily available design for servicing the space station. The booster can fly an orbiter up, turn around, land, refuel, and be ready to launch another orbiter in a matter of hours.

  3. A two-stage cyclone using microcentrifuge tubes for personal bioaerosol sampling.

    PubMed

    Lindsley, William G; Schmechel, Detlef; Chen, Bean T

    2006-11-01

    Personal aerosol samplers are widely used to monitor human exposure to airborne materials. For bioaerosols, interest is growing in analyzing samples using molecular and immunological techniques. This paper presents a personal sampler that uses a two-stage cyclone to collect bioaerosols into disposable 1.5 ml Eppendorf-type microcentrifuge tubes. Samples can be processed in the tubes for polymerase chain reaction (PCR) or immunoassays, and the use of multiple stages fractionates aerosol particles by aerodynamic diameter. The sampler was tested using fluorescent microspheres and aerosolized fungal spores. The sampler had first and second stage cut-off diameters of 2.6 microm and 1.6 microm at 2 l min(-1)(geometric standard deviation, GSD = 1.45 and 1.75), and 1.8 microm and 1 microm at 3.5 l min(-1)(GSD = 1.42 and 1.55). The sampler aspiration efficiency was >or=98% at both flow rates for particles with aerodynamic diameters of 3.1 microm or less. For 6.2 microm particles, the aspiration efficiency was 89% at 2 l min(-1) and 96% at 3.5 l min(-1). At 3.5 l min(-1), the sampler collected 92% of aerosolized Aspergillus versicolor and Penicillium chrysogenum spores inside the two microcentrifuge tubes, with less than 0.4% of the spores collecting on the back-up filter. The design and techniques given here are suitable for personal bioaerosol sampling, and could also be adapted to design larger aerosol samplers for longer-term atmospheric and indoor air quality sampling. PMID:17075620

  4. Greater India Basin hypothesis and a two-stage Cenozoic collision between India and Asia

    PubMed Central

    van Hinsbergen, Douwe J. J.; Lippert, Peter C.; Dupont-Nivet, Guillaume; McQuarrie, Nadine; Doubrovine, Pavel V.; Spakman, Wim; Torsvik, Trond H.

    2012-01-01

    Cenozoic convergence between the Indian and Asian plates produced the archetypical continental collision zone comprising the Himalaya mountain belt and the Tibetan Plateau. How and where India–Asia convergence was accommodated after collision at or before 52 Ma remains a long-standing controversy. Since 52 Ma, the two plates have converged up to 3,600 ± 35 km, yet the upper crustal shortening documented from the geological record of Asia and the Himalaya is up to approximately 2,350-km less. Here we show that the discrepancy between the convergence and the shortening can be explained by subduction of highly extended continental and oceanic Indian lithosphere within the Himalaya between approximately 50 and 25 Ma. Paleomagnetic data show that this extended continental and oceanic “Greater India” promontory resulted from 2,675 ± 700 km of North–South extension between 120 and 70 Ma, accommodated between the Tibetan Himalaya and cratonic India. We suggest that the approximately 50 Ma “India”–Asia collision was a collision of a Tibetan-Himalayan microcontinent with Asia, followed by subduction of the largely oceanic Greater India Basin along a subduction zone at the location of the Greater Himalaya. The “hard” India–Asia collision with thicker and contiguous Indian continental lithosphere occurred around 25–20 Ma. This hard collision is coincident with far-field deformation in central Asia and rapid exhumation of Greater Himalaya crystalline rocks, and may be linked to intensification of the Asian monsoon system. This two-stage collision between India and Asia is also reflected in the deep mantle remnants of subduction imaged with seismic tomography. PMID:22547792

  5. Evaluation of a two-stage framework for prediction using big genomic data.

    PubMed

    Jiang, Xia; Neapolitan, Richard E

    2015-11-01

    We are in the era of abundant 'big' or 'high-dimensional' data. These data afford us the opportunity to discover predictors of an event of interest, and to estimate occurrence of the event based on values of these predictors. For example, 'genome-wide association studies' examine millions of single-nucleotide polymorphisms (SNPs), along with disease status. We can learn SNPs that affect disease status from these data sets, and use the knowledge learned to predict disease likelihood. Owing to the large number of features, it is difficult for many prediction methods to use all the features directly. The ReliefF algorithm ranks a set of features in terms of how well they predict a target. It can be used to identify good predictors, which can then be provided to a prediction method. We compared the performance of eight prediction methods when predicting binary outcomes using high-dimensional discrete data sets. We performed two-stage prediction, where ReliefF is used in the first stage to identify good predictors. Bayesian network (BN)-based methods performed best overall. Furthermore, ReliefF did not improve their performance. The BN-based methods use the Bayesian Dirichlet Equivalent Uniform score to evaluate candidate models, and use BN inference algorithms to perform prediction. This score and these algorithms were developed for discrete variables. This perhaps explains why they perform better in this domain. Many prediction methods are available, and researchers have little reason for choosing one over the other in the domain of binary prediction using high-dimensional data sets. Our results indicate that the best choices overall are BN-based methods.

  6. Two-Stage orders sequencing system for mixed-model assembly

    NASA Astrophysics Data System (ADS)

    Zemczak, M.; Skolud, B.; Krenczyk, D.

    2015-11-01

    In the paper, the authors focus on the NP-hard problem of orders sequencing, formulated similarly to Car Sequencing Problem (CSP). The object of the research is the assembly line in an automotive industry company, on which few different models of products, each in a certain number of versions, are assembled on the shared resources, set in a line. Such production type is usually determined as a mixed-model production, and arose from the necessity of manufacturing customized products on the basis of very specific orders from single clients. The producers are nowadays obliged to provide each client the possibility to determine a huge amount of the features of the product they are willing to buy, as the competition in the automotive market is large. Due to the previously mentioned nature of the problem (NP-hard), in the given time period only satisfactory solutions are sought, as the optimal solution method has not yet been found. Most of the researchers that implemented inaccurate methods (e.g. evolutionary algorithms) to solving sequencing problems dropped the research after testing phase, as they were not able to obtain reproducible results, and met problems while determining the quality of the received solutions. Therefore a new approach to solving the problem, presented in this paper as a sequencing system is being developed. The sequencing system consists of a set of determined rules, implemented into computer environment. The system itself works in two stages. First of them is connected with the determination of a place in the storage buffer to which certain production orders should be sent. In the second stage of functioning, precise sets of sequences are determined and evaluated for certain parts of the storage buffer under certain criteria.

  7. Electroflotation clarifier to enhance nitrogen removal in a two-stage alternating aeration bioreactor.

    PubMed

    Cho, Kangwoo; Chung, Chong Min; Kim, Yun Jung; Hoffmann, Michael R; Chung, Tai Hak

    2013-01-01

    Stringent water treatment criteria and rapidly growing pollutant loads provoke the demand for retrofitting wastewater treatment plants towards a higher capacity. In this study, we assess a two stage alternating aeration (AA) bioreactor equipped with electroflotation (EF) clarifier, for nitrogen removal within a short hydraulic retention time (HRT). The EF under steady solids loading required a minimum unit height and gas: solids ratio of 0.006 for efficient clarification. The separated sludge blanket was further thickened with retaining stability when the cyclic solids loading was smaller than 1.0 kg m(-2). In the continuous operation of the bioreactor, the returned activated sludge concentration increased to more than 18,000 mg L(-1), while the effluent suspended solids concentration was lowered below 5 mg L(-1). Under influent chemical oxygen demand (COD)/total inorganic nitrogen (TIN) concentration of 300/30 mg L(-1), the TIN removal efficiency was near 70% with cycle time ratios of 0.17 and 0.27. Under higher influent COD concentration of 500mg L(-1), TIN removal efficiency was found to be 73.4% at a carbon:nitrogen (C:N) ratio of 10 and even higher (80.4%) at a C:N ratio of 16.6. The increased mixed liquor suspended solids concentrations (> 6000 mg L(-1)) under the high COD loading were efficiently maintained by using the EF clarifier. The results of this study demonstrate that an EF clarifier with a HRT of less than 1 h can support reliable nitrogen removal in the AA process that has a HRT of 6 h, even under increasing influent loadings.

  8. Multi-PLL with two-stage fusion to mitigate ionospheric scintillation effects on GPS receivers

    NASA Astrophysics Data System (ADS)

    Xu, Rui; Liu, Zhizhao; Chen, Wu

    2015-07-01

    Ionospheric scintillation poses a great threat to the reliability and accuracy of Global Positioning System (GPS) in various applications. It can increase tracking errors of the phase-locked loop (PLL) in a GPS receiver and even cause the PLL loss of lock under severe scintillations. To mitigate the effect of scintillation on GPS receivers, especially to reduce the occurrence of loss of lock, a multi-PLL with two-stage fusion (i.e., tracking fusion and output fusion) is proposed in this paper. This algorithm integrates several parallel sub-PLLs with different loop parameters into one channel to track one GPS satellite's signal. Every sub-PLL has its own discriminator, loop filter, carrier numerical controlled oscillator, and a tracking fusion (i.e., the first stage fusion). The tracking fusion of each sub-PLL integrates the Doppler frequency measurements from all other sub-PLLs to detect the state of its own sub-PLL and feeds back reliable Doppler frequency measurements. Simultaneously, the tracking fusion outputs the Doppler frequency measurements to the second stage fusion (i.e., output fusion), which integrates the outputs from all tracking fusions to provide continuous and accurate Doppler frequency measurements for the following positioning/navigation estimator. Performances of the proposed algorithm are tested using real-world GPS data with different levels of scintillations and compared with results from single-PLLs. For three real-world scintillation cases (S4 = 0.26-1.1, σϕ = 0.05-1.49 rad, and average C/N0 = 41.2-45.7 dB Hz), the multi-PLL algorithm performs more robustly than the single-PLLs and is able to keep tracking in all scintillation cases.

  9. An improved sup 222 Rn canister using a two-stage charcoal system

    SciTech Connect

    Scarpitta, S.C.; Harley, N.H. )

    1991-02-01

    A prototype for an improved passive {sup 222}Rn canister (R-Canister) was designed and compared to conventional charcoal canisters for its adsorptive and desorptive characteristics following exposures to {sup 222}Rn at 23{degrees}C in the presence of water vapor. The R-Canister, containing a two-stage charcoal system, minimizes the adverse effects of water vapor by maintaining the amount of adsorbed water vapor in the primary Rn adsorbent below the break-point of the charcoal. This is achieved by the placement of a desiccant charcoal cartridge 6 cm above the primary Rn adsorbent. The optimal bed depth of the primary adsorbent, determined from a diffusion study, was found to be 2.3 cm. The measured value for the effective diffusion coefficient of RN in a peat-based charcoal at 15% humidity and 25{degrees}C is 7.97 x 10(-10) m2 s-1. Exposures to 70% humidity for 7 d increased the buildup time-constant of Rn in the R-Canisters by 33% as compared to R-Canisters exposed to 15% humidity. At relative humidities ranging from 15-70%, the {sup 222}Rn buildup time-constant of the R-Canister ranged from 43-94 h, whereas the desorption time-constant ranged from 46-64 h. Typical buildup time-constants and desorption time-constants for conventional fully-opened charcoal canisters currently in field use ranged from 30-43 h and 17-29 h, respectively, over the same range of humidities.

  10. Neural Mechanisms of Human Perceptual Learning: Electrophysiological Evidence for a Two-Stage Process

    PubMed Central

    Hamamé, Carlos M.; Cosmelli, Diego; Henriquez, Rodrigo; Aboitiz, Francisco

    2011-01-01

    Background Humans and other animals change the way they perceive the world due to experience. This process has been labeled as perceptual learning, and implies that adult nervous systems can adaptively modify the way in which they process sensory stimulation. However, the mechanisms by which the brain modifies this capacity have not been sufficiently analyzed. Methodology/Principal Findings We studied the neural mechanisms of human perceptual learning by combining electroencephalographic (EEG) recordings of brain activity and the assessment of psychophysical performance during training in a visual search task. All participants improved their perceptual performance as reflected by an increase in sensitivity (d') and a decrease in reaction time. The EEG signal was acquired throughout the entire experiment revealing amplitude increments, specific and unspecific to the trained stimulus, in event-related potential (ERP) components N2pc and P3 respectively. P3 unspecific modification can be related to context or task-based learning, while N2pc may be reflecting a more specific attentional-related boosting of target detection. Moreover, bell and U-shaped profiles of oscillatory brain activity in gamma (30–60 Hz) and alpha (8–14 Hz) frequency bands may suggest the existence of two phases for learning acquisition, which can be understood as distinctive optimization mechanisms in stimulus processing. Conclusions/Significance We conclude that there are reorganizations in several neural processes that contribute differently to perceptual learning in a visual search task. We propose an integrative model of neural activity reorganization, whereby perceptual learning takes place as a two-stage phenomenon including perceptual, attentional and contextual processes. PMID:21541280

  11. Greater India Basin hypothesis and a two-stage Cenozoic collision between India and Asia.

    PubMed

    van Hinsbergen, Douwe J J; Lippert, Peter C; Dupont-Nivet, Guillaume; McQuarrie, Nadine; Doubrovine, Pavel V; Spakman, Wim; Torsvik, Trond H

    2012-05-15

    Cenozoic convergence between the Indian and Asian plates produced the archetypical continental collision zone comprising the Himalaya mountain belt and the Tibetan Plateau. How and where India-Asia convergence was accommodated after collision at or before 52 Ma remains a long-standing controversy. Since 52 Ma, the two plates have converged up to 3,600 ± 35 km, yet the upper crustal shortening documented from the geological record of Asia and the Himalaya is up to approximately 2,350-km less. Here we show that the discrepancy between the convergence and the shortening can be explained by subduction of highly extended continental and oceanic Indian lithosphere within the Himalaya between approximately 50 and 25 Ma. Paleomagnetic data show that this extended continental and oceanic "Greater India" promontory resulted from 2,675 ± 700 km of North-South extension between 120 and 70 Ma, accommodated between the Tibetan Himalaya and cratonic India. We suggest that the approximately 50 Ma "India"-Asia collision was a collision of a Tibetan-Himalayan microcontinent with Asia, followed by subduction of the largely oceanic Greater India Basin along a subduction zone at the location of the Greater Himalaya. The "hard" India-Asia collision with thicker and contiguous Indian continental lithosphere occurred around 25-20 Ma. This hard collision is coincident with far-field deformation in central Asia and rapid exhumation of Greater Himalaya crystalline rocks, and may be linked to intensification of the Asian monsoon system. This two-stage collision between India and Asia is also reflected in the deep mantle remnants of subduction imaged with seismic tomography.

  12. Study of high power, two-stage, TWT X-band amplifier

    SciTech Connect

    Wang, P.; Golkowski, C.; Hayashi, Y.; Ivers, J.D.; Nation, J.A.; Schachter, L.

    1999-07-01

    A disk loaded slow wave structure with a cold wave phase (without electron beam) velocity of the TM{sub 01} wave greater than the speed of light (1.05c) is used as the electron bunching stage of a two stage X-band amplifier. The high phase velocity section produces well defined electron bunches. The second section, where the cold wave phase velocity is (0.84c), i.e., less than beam velocity of 0.91c, is used to generate the high output power microwave radiation. The tightly bunched beam from the high phase velocity section enhances the beam energy conversion into microwave radiation compared to that obtained with a synchronous electron-wave bunches. The amplifier is driven by a 7mm diameter 750 kV, 500A pencil electron beam. The structure, which has a 4 GHz bandwidth, produces an amplified output with a power in the range of 20--60 MW. At higher output powers (>60MW) pulse shortening develops. The authors suspect that the pulse shortening is a result of excitation of the hybrid mode, HEM{sub 11}, which overlaps (about 0.5 GHz separation) with the frequency domain of the desired TM{sub 0.1} mode. A new amplifier with similar phase velocity characteristics but with a 1 GHz bandwidth and an HEM{sub 11}, TM{sub 01} mode frequency separation of 3.3 GHz has been designed and constructed. The interaction frequency for the HEM mode is above the passband of the TM mode. Testing is in progress. The performance of the new amplifier will be compared with results obtained using the earlier configuration.

  13. Extents of alkane combustion during rapid compression leading to single and two stage ignition

    SciTech Connect

    Cox, A.; Griffiths, J.F.; Mohamed, C.; Curran, H.; Pitz, W.J.; Westbrook, C.K.

    1996-02-01

    Extents of reactant consumption have been measured during the course of spontaneous ignition following rapid compression of N-pentane and N-heptane and also of PRF 60 (N-heptane = i-octane, 2.2.4 trimethylpentane) in stoichiometric mixtures with air. Compressed gas temperatures of 720-750 K and 845-875 K were studied at reactant densities of 131 mol m{sup minus 3}. At the lower gas temperature there was no evidence of reactant consumption during the course of the compression stroke. Two-stage ignition occurred at these temperatures, but only modest proportions of n-pentane were consumed during the first stage (< 15%) whereas about 40% of proportions of n- heptane reacted under the same conditions. At the higher compressed gas temperature the oxidation of n-pentane began only after the piston had stopped, whereas more than 30% of the n-heptane had already been consumed in the final stage of the compression stroke. The behavior of the PRF 60 mixture differed somewhat from that of N- pentane despite the similarly of the research octane numbers. Although there was a preferential oxidation of n-heptane at T{sub c} = 850K, which persisted throughout the early development of spontaneous ignition during the post-compression period, oxidation of both components of the PRF 60 mixture began before the piston had stopped. Numerical simulations of the spontaneous ignition under conditions resembling those of the rapid compression experiments show that the predicted reactivity from detailed kinetics are consistent with the observed features. Insights into the kinetic interactions that give rise to the relative reactivities of the primary reference fuel components are established

  14. Pilot plant testing of IGT`s two-stage fluidized-bed/cyclonic agglomerating combustor

    SciTech Connect

    Rehmat, A.; Mensinger, M.C.; Richardson, T.L.

    1993-12-31

    The Institute of Gas Technology (IGT) is conducting a multi-year experimental program to develop and test, through pilot-scale operation, IGT`s two-stage fluidized-bed/cyclonic agglomerating combustor (AGGCOM). The AGGCOM process is based on combining the fluidized-bed agglomeration and gasification technology with the cyclonic combustion technology, both of which have been developed at IGT over many years. AGGCOM is a unique and extremely flexible combustor that can operate over a wide range of conditions in the fluidized-bed first stage from low temperature (desorption) to high temperature (agglomeration), including gasification of high-energy-content wastes. The ACCCOM combustor can easily and efficiently destroy solid, liquid, and gaseous organic wastes, while isolating solid inorganic contaminants within an essentially non-leachable glassy matrix, suitable for disposal in ordinary landfills. Fines elutriated from the first stage are captured by a high-efficiency cyclone and returned to the fluidized bed for ultimate incorporation into the agglomerates. Intense mixing in the second-stage cyclonic combustor ensures high destruction and removal efficiencies (DRE) for organic compounds that may be present in the feed material. This paper presents an overview of the experimental development of the AGGCOM process and progress made to date in designing, constructing, and operating the 6-ton/day AGGCOM pilot plant. Results of the bench-scale tests conducted to determine the operating conditions necessary to agglomerate a soil were presented at the 1991 Incineration Conference. On-site construction of the AGGCOM pilot plant was initiated in August 1992 and completed at the end of March 1993, with shakedown testing following immediately thereafter. The initial tests in the AGGCOM pilot plant will focus on the integrated operation of both stages of the combustor and will be conducted with ``clean`` topsoil.

  15. Inspection of integrated two-stage liquefaction products as petroleum refining feedstocks

    SciTech Connect

    Winschel, R.A.; Burke, F.P.; Zhou, P.

    1991-12-31

    Regardless of the specific technology used to produce transportation fuels from coal, the net product of the liquefaction process will have to undergo additional refining to make finished products. Consequently, there is a need to characterize the material that exits the liquefaction plant as net product and enters the refinery as feed. The net product of the Integrated Two-Stage Liquefaction (ITSL) process, as practiced at the 6 ton/day (5.5 tonne/day) Wilsonville, Alabama (USA) plant, is a distillable liquid boiling predominantly below 650{degrees}F (343{degrees}C). Products from ITSL operations at the Wilsonville plant were evaluated through the use of standard petroleum tests on several occasions. However, those evaluations were performed on materials generated much earlier in the ITSL campaign and, thus, may not be representative of products generated from the process as it is currently configured. For this work, net products were obtained for analysis from ITSL operations during fully lined-out material balance operating periods.Samples were taken fro Run 259G, which was operated with Ireland Mine coal (hvAb, Pittsburgh seam, West Virginia, USA) and from Run 260D, which was operated with Black Thunder Mine coal (subbituminous, Powder River Basin, Wyoming, USA). A complete suite of light crude oil assay tests was performed on each sample. These assays included tests on the whole coal liquid, and the separated naphtha (<380{degrees}F/193{degrees}C), jet fuel or kerosene (380{degrees}F/193{degrees}C {times} 510{degrees}F/266{degrees}C), and diesel fuel (>510{degrees}F/266{degrees}C) fractions. The results of the assays were compared against typical petroleum product specifications. The discussion will concentrate on the test results of the bituminous coal product.

  16. A two-stage evolutionary process for designing TSK fuzzy rule-based systems.

    PubMed

    Cordon, O; Herrera, F

    1999-01-01

    Nowadays, fuzzy rule-based systems are successfully applied to many different real-world problems. Unfortunately, relatively few well-structured methodologies exist for designing and, in many cases, human experts are not able to express the knowledge needed to solve the problem in the form of fuzzy rules. Takagi-Sugeno-Kang (TSK) fuzzy rule-based systems were enunciated in order to solve this design problem because they are usually identified using numerical data. In this paper we present a two-stage evolutionary process for designing TSK fuzzy rule-based systems from examples combining a generation stage based on a (mu, lambda)-evolution strategy, in which the fuzzy rules with different consequents compete among themselves to form part of a preliminary knowledge base, and a refinement stage in which both the antecedent and consequent parts of the fuzzy rules in this previous knowledge base are adapted by a hybrid evolutionary process composed of a genetic algorithm and an evolution strategy to obtain the final Knowledge base whose rules cooperate in the best possible way. Some aspects make this process different from others proposed until now: the design problem is addressed in two different stages, the use of an angular coding of the consequent parameters that allows us to search across the whole space of possible solutions, and the use of the available knowledge about the system under identification to generate the initial populations of the Evolutionary Algorithms that causes the search process to obtain good solutions more quickly. The performance of the method proposed is shown by solving two different problems: the fuzzy modeling of some three-dimensional surfaces and the computing of the maintenance costs of electrical medium line in Spanish towns. Results obtained are compared with other kind of techniques, evolutionary learning processes to design TSK and Mamdani-type fuzzy rule-based systems in the first case, and classical regression and neural modeling

  17. Two-stage crystallization of charged colloids under low supersaturation conditions.

    PubMed

    Kratzer, Kai; Arnold, Axel

    2015-03-21

    We report simulations on the homogeneous liquid-fcc nucleation of charged colloids for both low and high contact energy values. As a precursor for crystal formation, we observe increased local order at the position where the crystal will form, but no correlations with the local density. Thus, the nucleation is driven by order fluctuations rather than density fluctuations. Our results also show that the transition involves two stages in both cases, first a transition of liquid → bcc, followed by a bcc → hcp/fcc transition. Both transitions have to overcome free energy barriers, so that a spherical bcc-like cluster is formed first, in which the final fcc structure is nucleated mainly at the surface of the crystallite. This means that the second stage bcc-fcc phase transition is a heterogeneous nucleation in the partially grown solid phase, even though we start from a homogeneous bulk liquid. The height of the bcc → hcp/fcc free energy barrier strongly depends on the contact energies of the colloids. For low contact energy this barrier is low, so that the bcc → hcp/fcc transition occurs spontaneously. For the higher contact energy, the second barrier is too high to be crossed spontaneously by the colloidal system. However, it was possible to ratchet the system over the second barrier and to transform the bcc nuclei into the stable hcp/fcc phase. The transitions are dominated by the first liquid-bcc transition and can be described by classical nucleation theory using an effective surface tension.

  18. Two-stage rifting in the Kenya rift: implications for half-graben models

    NASA Astrophysics Data System (ADS)

    Mugisha, F.; Ebinger, C. J.; Strecker, M.; Pope, D.

    1997-09-01

    The Kerio sub-basin in the northern Kenya rift is a transitional area between the southern Kenya rift, where crustal thickness is 30 km, and the northern Kenya rift, where crustal thickness is 20 km. The lack of data on the shallow crustal structure, geometry of rift-bounding faults, and rift evolution makes it difficult to determine if the crustal thickness variations are due to pre-rift structure, or along-axis variations in crustal stretching. We reprocessed reflection seismic data acquired for the National Oil Corporation of Kenya, and integrated results with field and gravity observations to (1) delineate the sub-surface geometry of the Kerio sub-basin, (2) correlate seismic stratigraphic sequences with dated strata exposed along the basin margins, and (3) use new and existing results to propose a two-stage rifting model for the central Kenya rift. Although a classic half-graben form previously had been inferred from the attitude of uppermost strata, new seismic data show a more complex form in the deeper basin: a narrow full-graben bounded by steep faults. We suggest that the complex basin form and the northwards increase in crustal thinning are caused by the superposition of two or more rifting events. The first rifting stage may have occurred during Palaeogene time contemporaneous with sedimentation and rifting in northwestern Kenya and southern Sudan. The distribution of seismic sequences suggests that a phase of regional thermal subsidence occurred prior to renewed faulting and subsidence at about 12 Ma after the eruption of flood phonolites throughout the central Kenya rift. A new border fault developed during the second rifting stage, effectively widening the basin. Gravity and seismic data indicate sedimentary and volcanic strata filling the basin are 6 km thick, with up to 4 km deposited during the first rifting stage.

  19. Protozoan Grazing, Bacterial Activity, and Mineralization in Two-Stage Continuous Cultures

    PubMed Central

    Bloem, Jaap; Starink, Mathieu; Bär-Gilissen, Marie-José B.; Cappenberg, Thomas E.

    1988-01-01

    In two-stage continuous cultures, at bacterial concentrations, biovolumes, and growth rates similar to values found in Lake Vechten, ingestion rates of heterotrophic nanoflagellates (HNAN) increased from 2.3 bacteria HNAN−1 · h−1 at a growth rate of 0.15 day−1 to 9.2 bacteria · HNAN−1 · h−1 at a growth rate of 0.65 day−1. On a yeast extract medium with a C/N/P ratio of 100:15:1.2 (Redfield ratio), a mixed bacterial population showed a yield of 18% (C/C) and a specific carbon content of 211 fg of C · μm−3. The HNAN carbon content and yield were estimated at 127 fg of C · μm−3 and 47% (C/C). Although P was not growth limiting, HNAN accelerated the mineralization of PO4-P from dissolved organic matter by 600%. The major mechanism of P remineralization appeared to be direct consumption of bacteria by HNAN. N mineralization was performed mainly (70%) by bacteria but was increased 30% by HNAN. HNAN did not enhance the decomposition of the relatively mineral-rich dissolved organic matter. An accelerated decomposition of organic carbon by protozoa may be restricted to mineral-poor substrates and may be explained mainly by protozoan nutrient regeneration. Growth and grazing in the cultures were compared with methods for in situ estimates. Thymidine incorporation by actively growing bacteria yielded an empirical conversion factor of 1.1 × 1018 bacteria per mol of thymidine incorporated into DNA. However, nongrowing bacteria also showed considerable incorporation. Protozoan grazing was found to be accurately measured by uptake of fluorescently labeled bacteria, whereas artificial fluorescent microspheres were not ingested, and selective prokaryotic inhibitors blocked not only bacterial growth but also protozoan grazing. PMID:16347801

  20. Urinary Angiotensinogen Level Predicts AKI in Acute Decompensated Heart Failure: A Prospective, Two-Stage Study

    PubMed Central

    Yang, Xiaobing; Chen, Chunbo; Tian, Jianwei; Zha, Yan; Xiong, Yuqin; Sun, Zhaolin; Chen, Pingyan; Li, Jun; Yang, Tiecheng; Ma, Changsheng; Liu, Huafeng

    2015-01-01

    A major challenge in prevention and early treatment of acute cardiorenal syndrome (CRS) is the lack of high-performance predictors. To test the hypothesis that urinary angiotensinogen (uAGT) is an early predictor for acute CRS and 1-year prognosis in patients with acute decompensated heart failure (ADHF), we performed a prospective, two-stage, multicenter cohort study in patients with ADHF. In stage I (test set), 317 patients were recruited from four centers. In stage II (validation set), 119 patients were enrolled from two other centers. Daily uAGT levels were analyzed consecutively. AKI was defined according to Kidney Disease Improving Global Outcomes (KDIGO) Clinical Practice Guidelines. In stage I, 104 (32.8%) patients developed AKI during hospitalization. Daily uAGT peaked on the first hospital day in patients who subsequently developed AKI. After multivariable adjustment, the highest quartile of uAGT on admission was associated with a 50-fold increased risk of AKI compared with the lowest quartile. For predicting AKI, uAGT (area under the receiver-operating characteristic curve [AUC]=0.84) outperformed urinary neutrophil gelatinase-associated lipocalin (AUC=0.78), the urinary albumin/creatinine ratio (AUC=0.71), and the clinical model (AUC=0.77). Survivors in stage I were followed prospectively for 1 year after hospital discharge. The uAGT level independently predicted the risk of 1-year mortality (adjusted odds ratio, 4.5; 95% confidence interval, 2.1 to 9.5) and rehospitalization (adjusted odds ratio, 3.6; 95% confidence interval, 1.6 to 5.7). The ability of uAGT in predicting AKI was validated in stage II (AUC=0.79). In conclusion, uAGT is a strong predictor for acute CRS and 1-year prognosis in ADHF. PMID:25722365