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Sample records for advanced undergraduate laboratory

  1. A Multistep Synthesis for an Advanced Undergraduate Organic Chemistry Laboratory

    ERIC Educational Resources Information Center

    Chang Ji; Peters, Dennis G.

    2006-01-01

    Multistep syntheses are often important components of the undergraduate organic laboratory experience and a three-step synthesis of 5-(2-sulfhydrylethyl) salicylaldehyde was described. The experiment is useful as a special project for an advanced undergraduate organic chemistry laboratory course and offers opportunities for students to master a…

  2. Cavity Ring down Spectroscopy Experiment for an Advanced Undergraduate Laboratory

    ERIC Educational Resources Information Center

    Stacewicz, T.; Wasylczyk, P.; Kowalczyk, P.; Semczuk, M.

    2007-01-01

    A simple experiment is described that permits advanced undergraduates to learn the principles and applications of the cavity ring down spectroscopy technique. The apparatus is used for measurements of low concentrations of NO[subscript 2] produced in air by an electric discharge. We present the setup, experimental procedure, data analysis and some…

  3. Acoustic resonance spectroscopy for the advanced undergraduate laboratory

    NASA Astrophysics Data System (ADS)

    Franco-Villafañe, J. A.; Flores-Olmedo, E.; Báez, G.; Gandarilla-Carrillo, O.; Méndez-Sánchez, R. A.

    2012-11-01

    We present a simple experiment that allows advanced undergraduates to learn the principles and applications of spectroscopy. The technique, known as acoustic resonance spectroscopy, is applied to study a vibrating rod. The setup includes electromagnetic-acoustic transducers, an audio amplifier and a vector network analyzer. Typical results of compressional, torsional and bending waves are analyzed and compared with analytical results.

  4. A Comprehensive Microfluidics Device Construction and Characterization Module for the Advanced Undergraduate Analytical Chemistry Laboratory

    ERIC Educational Resources Information Center

    Piunno, Paul A. E.; Zetina, Adrian; Chu, Norman; Tavares, Anthony J.; Noor, M. Omair; Petryayeva, Eleonora; Uddayasankar, Uvaraj; Veglio, Andrew

    2014-01-01

    An advanced analytical chemistry undergraduate laboratory module on microfluidics that spans 4 weeks (4 h per week) is presented. The laboratory module focuses on comprehensive experiential learning of microfluidic device fabrication and the core characteristics of microfluidic devices as they pertain to fluid flow and the manipulation of samples.…

  5. Advanced Undergraduate-Laboratory Experiment on Electron Spin Resonance in Single-Crystal Ruby

    ERIC Educational Resources Information Center

    Collins, Lee A.; And Others

    1974-01-01

    An electron-spin-resonance experiment which has been successfully performed in an advanced undergraduate physics laboratory is described. A discussion of that part of the theory of magnetic resonance necessary for the understanding of the experiment is also provided in this article. (DT)

  6. An Advanced Undergraduate Chemistry Laboratory Experiment Exploring NIR Spectroscopy and Chemometrics

    ERIC Educational Resources Information Center

    Wanke, Randall; Stauffer, Jennifer

    2007-01-01

    An advanced undergraduate chemistry laboratory experiment to study the advantages and hazards of the coupling of NIR spectroscopy and chemometrics is described. The combination is commonly used for analysis and process control of various ingredients used in agriculture, petroleum and food products.

  7. The Scanning Electron Microscope As An Accelerator For The Undergraduate Advanced Physics Laboratory

    SciTech Connect

    Peterson, Randolph S.; Berggren, Karl K.; Mondol, Mark

    2011-06-01

    Few universities or colleges have an accelerator for use with advanced physics laboratories, but many of these institutions have a scanning electron microscope (SEM) on site, often in the biology department. As an accelerator for the undergraduate, advanced physics laboratory, the SEM is an excellent substitute for an ion accelerator. Although there are no nuclear physics experiments that can be performed with a typical 30 kV SEM, there is an opportunity for experimental work on accelerator physics, atomic physics, electron-solid interactions, and the basics of modern e-beam lithography.

  8. An ultrafast optics undergraduate advanced laboratory with a mode-locked fiber laser

    NASA Astrophysics Data System (ADS)

    Schaffer, Andrew; Fredrick, Connor; Hoyt, Chad; Jones, Jason

    2015-05-01

    We describe an ultrafast optics undergraduate advanced laboratory comprising a mode-locked erbium fiber laser, auto-correlation measurements, and an external, free-space parallel grating dispersion compensation apparatus. The simple design of the stretched pulse laser uses nonlinear polarization rotation mode-locking to produce pulses at a repetition rate of 55 MHz and average power of 5.5 mW. Interferometric and intensity auto-correlation measurements are made using a Michelson interferometer that takes advantage of the two-photon nonlinear response of a common silicon photodiode for the second order correlation between 1550 nm laser pulses. After a pre-amplifier and compression, pulse widths as narrow as 108 fs are measured at 17 mW average power. A detailed parts list includes previously owned and common components used by the telecommunications industry, which may decrease the cost of the lab to within reach of many undergraduate and graduate departments. We also describe progress toward a relatively low-cost optical frequency comb advanced laboratory. NSF EIR #1208930.

  9. Undergraduate Chemistry Laboratory

    ERIC Educational Resources Information Center

    Bretz, Stacey Lowery; Fay, Michael; Bruck, Laura B.; Towns, Marcy H.

    2013-01-01

    Forty chemistry faculty from American Chemical Society-approved departments were interviewed to determine their goals for undergraduate chemistry laboratory. Faculty were stratified by type of institution, departmental success with regard to National Science Foundation funding for laboratory reform, and level of laboratory course. Interview…

  10. Development, Evaluation and Use of a Student Experience Survey in Undergraduate Science Laboratories: The Advancing Science by Enhancing Learning in the Laboratory Student Laboratory Learning Experience Survey

    NASA Astrophysics Data System (ADS)

    Barrie, Simon C.; Bucat, Robert B.; Buntine, Mark A.; Burke da Silva, Karen; Crisp, Geoffrey T.; George, Adrian V.; Jamie, Ian M.; Kable, Scott H.; Lim, Kieran F.; Pyke, Simon M.; Read, Justin R.; Sharma, Manjula D.; Yeung, Alexandra

    2015-07-01

    Student experience surveys have become increasingly popular to probe various aspects of processes and outcomes in higher education, such as measuring student perceptions of the learning environment and identifying aspects that could be improved. This paper reports on a particular survey for evaluating individual experiments that has been developed over some 15 years as part of a large national Australian study pertaining to the area of undergraduate laboratories-Advancing Science by Enhancing Learning in the Laboratory. This paper reports on the development of the survey instrument and the evaluation of the survey using student responses to experiments from different institutions in Australia, New Zealand and the USA. A total of 3153 student responses have been analysed using factor analysis. Three factors, motivation, assessment and resources, have been identified as contributing to improved student attitudes to laboratory activities. A central focus of the survey is to provide feedback to practitioners to iteratively improve experiments. Implications for practitioners and researchers are also discussed.

  11. Advancing Space Sciences through Undergraduate Research Experiences at UC Berkeley's Space Sciences Laboratory - a novel approach to undergraduate internships for first generation community college students

    NASA Astrophysics Data System (ADS)

    Raftery, C. L.; Davis, H. B.; Peticolas, L. M.; Paglierani, R.

    2015-12-01

    The Space Sciences Laboratory at UC Berkeley launched an NSF-funded Research Experience for Undergraduates (REU) program in the summer of 2015. The "Advancing Space Sciences through Undergraduate Research Experiences" (ASSURE) program recruited heavily from local community colleges and universities, and provided a multi-tiered mentorship program for students in the fields of space science and engineering. The program was focussed on providing a supportive environment for 2nd and 3rd year undergraduates, many of whom were first generation and underrepresented students. This model provides three levels of mentorship support for the participating interns: 1) the primary research advisor provides academic and professional support. 2) The program coordinator, who meets with the interns multiple times per week, provides personal support and helps the interns to assimilate into the highly competitive environment of the research laboratory. 3) Returning undergraduate interns provided peer support and guidance to the new cohort of students. The impacts of this program on the first generation students and the research mentors, as well as the lessons learned will be discussed.

  12. One-dimensional light localization with classical scatterers: An advanced undergraduate laboratory experiment

    NASA Astrophysics Data System (ADS)

    Kemp, K. J.; Barker, S.; Guthrie, J.; Hagood, B.; Havey, M. D.

    2016-10-01

    The phenomenon of electronic wave localization through disorder remains an important area of fundamental and applied research. Localization of all wave phenomena, including light, is thought to exist in a restricted one-dimensional geometry. We present here a series of experiments to illustrate, using a straightforward experimental arrangement and approach, the localization of light in a quasi-one-dimensional physical system. In the experiments, reflected and transmitted light from a stack of glass slides of varying thickness reveals an Ohm's law type behavior for small thicknesses, and evolution to exponential decay of the transmitted power for larger thicknesses. For larger stacks of slides, a weak departure from one-dimensional behavior is also observed. The experiment and analysis of the results, showing many of the essential features of wave localization, is relatively straightforward, economical, and suitable for laboratory experiments at an undergraduate level.

  13. An Advanced Chemistry Laboratory Program.

    ERIC Educational Resources Information Center

    Wise, John H.

    The Advanced Chemistry Laboratory Program is a project designed to devise experiments to coordinate the use of instruments in the laboratory programs of physical chemistry, instrumental analysis, and inorganic chemistry at the advanced undergraduate level. It is intended that such experiments would incorporate an introduction to the instrument…

  14. Assembly of a Modular Fluorimeter and Associated Software: Using LabVIEW in an Advanced Undergraduate Analytical Chemistry Laboratory

    ERIC Educational Resources Information Center

    Algar, W. Russ; Massey, Melissa; Krull, Ulrich J.

    2009-01-01

    A laboratory activity for an upper-level undergraduate course in instrumental analysis has been created around LabVIEW. Students learn rudimentary programming and interfacing skills during the construction of a fluorimeter assembled from common modular components. The fluorimeter consists of an inexpensive data acquisition module, LED light…

  15. Glycobiology, How to Sugar-Coat an Undergraduate Advanced Biochemistry Laboratory

    ERIC Educational Resources Information Center

    McReynolds, Katherine D.

    2006-01-01

    A second semester biochemistry laboratory has been implemented as an independent projects course at California State University, Sacramento since 1999. To incorporate aspects of carbohydrate biochemistry, or glycobiology, into our curriculum, projects in lectin isolation and purification were undertaken over the course of two semesters. Through…

  16. Dipeptide Structural Analysis Using Two-Dimensional NMR for the Undergraduate Advanced Laboratory

    ERIC Educational Resources Information Center

    Gonzalez, Elizabeth; Dolino, Drew; Schwartzenburg, Danielle; Steiger, Michelle A.

    2015-01-01

    A laboratory experiment was developed to introduce students in either an organic chemistry or biochemistry lab course to two-dimensional nuclear magnetic resonance (2D NMR) spectroscopy using simple biomolecules. The goal of this experiment is for students to understand and interpret the information provided by a 2D NMR spectrum. Students are…

  17. Synthesis of a Partially Protected Azidodeoxy Sugar. A Project Suitable for the Advanced Undergraduate Organic Chemistry Laboratory

    NASA Astrophysics Data System (ADS)

    Norris, Peter; Freeze, Scott; Gabriel, Christopher J.

    2001-01-01

    The synthetic chemistry of carbohydrates provides a wealth of possible experiments for the undergraduate organic chemistry laboratory. However, few appropriate examples have been developed to date. With this simple two-step synthesis of a partially protected azidodeoxy sugar, we demonstrate several important concepts introduced in undergraduate chemistry (alcohol activation, steric hindrance, nucleophilic substitution) while offering products that are readily amenable to analysis by high field NMR. Students are exposed to techniques such as monitoring reactions by TLC, workup of reaction mixtures, and isolation by flash chromatography. Suitable methods for analysis of products include NMR, IR, MS, and polarimetry.

  18. Water bottle rocket in undergraduate laboratory

    NASA Astrophysics Data System (ADS)

    Schultz, William

    2012-11-01

    In the winter semester of 2012, we implemented the modeling and testing of a water bottle rocket in ME 495, the Senior Laboratory in Mechanical Engineering at the University of Michigan. The four week lab was the most well received by the students in recent memory. There were significant challenges, but the result was a thorough review of their undergraduate fluids class with some advanced concepts such as directional stability of a projectile. The student teams designed their own rockets based on one of many standard 20 ounce soft drink bottles. The culminating contest brought impressive results and a surprise ending.

  19. Undergraduate Laboratory for Surface Science

    NASA Astrophysics Data System (ADS)

    Okumura, Mitchio; Beauchamp, Jesse L.; Dickert, Jeffrey M.; Essy, Blair R.; Claypool, Christopher L.

    1996-02-01

    Surface science has developed into a multidisciplinary field of research with applications ranging from heterogeneous catalysis to semiconductor etching (1). Aspects of surface chemistry are now included in physical chemistry textbooks (2) and undergraduate curricula (3), but the perceived cost and complexity of equipment has deterred the introduction of surface science methods in undergraduate laboratories (4). Efforts to expose chemistry undergraduates to state-of-the-art surface instrumentation have just begun (5). To provide our undergraduates with hands-on experience in using standard techniques for characterizing surface morphology, adsorbates, kinetics, and reaction mechanisms, we have developed a set of surface science experiments for our physical chemistry laboratory sequence. The centerpiece of the laboratory is an ultrahigh vacuum (UHV) chamber for studies of single crystal surfaces. This instrument, shown in the figure, has surface analysis capabilities including low energy electron diffraction (LEED), Auger spectroscopy, and temperature-programmed desorption (TPD). The laboratory exercises involve experiments on the well-studied Pt(111) surface. Students prepare a previously mounted single crystal sample by sputtering it with an argon ion gun and heating it under O2. Electron diffraction patterns from the cleaned surface are then obtained with a reverse view LEED apparatus (Princeton Instruments). Images are captured by a charge-coupled device (CCD) camera interfaced to a personal computer for easy downloading and subsequent analysis. Although the LEED images from a Pt(111) surface can be readily interpreted using simple diffraction arguments, this lab provides an excellent context for introducing Miller indices and reciprocal lattices (6). The surface chemical composition can be investigated by Auger spectroscopy, using the LEED apparatus as a simple energy analyzer. The temperature programmed desorption experiment, which is nearly complete, will be

  20. Overhauling the Undergraduate Physics Laboratory in India.

    ERIC Educational Resources Information Center

    Khandelwal, D. P.

    1993-01-01

    Highlights the need to make the undergraduate physics laboratory more exciting and commensurate with the time assigned for it in the curriculum. Suggests establishing a model undergraduate physics laboratory at one place then reproducing it in five places for a massive reorientation program for teachers. Contains brief outlines of 30 experiments…

  1. HPLC for Undergraduate Introductory Laboratories

    NASA Astrophysics Data System (ADS)

    van Arman, Scott A.; Thomsen, Marcus W.

    1997-01-01

    Undergraduate laboratories continue increasing the use of instrumentation in teaching. One technique that is growing in popularity is HPLC. We have designed a set of simple HPLC separations as part of an introductory set of projects that serve as an introduction to chromatography early in the organic course. We have introduced quantitative analysis to the common separation of analgesics so that students may identify the composition of an unknown commercial tablet. Derived from this system is a Ån adaptation of the well known separation of nucleosides by reversed-phase HPLC such that students can quantitatively identify the components of an unknown "RNA digest." Students must determine retention times and an instrumental response factor for each component. For both separations all components elute in × 6 min. and baseline separation is excellent. From the retention times of standard individual component samples the identity of each component in the sample can be ascertained. From the instrumental response factors of standard individual component samples the percent composition of each component can be calculated.

  2. Fluid Flow Experiment for Undergraduate Laboratory.

    ERIC Educational Resources Information Center

    Vilimpochapornkul, Viroj; Obot, Nsima T.

    1986-01-01

    The undergraduate fluid mechanics laboratory at Clarkson University consists of three experiments: mixing; drag measurements; and fluid flow and pressure drop measurements. The latter experiment is described, considering equipment needed, procedures used, and typical results obtained. (JN)

  3. Synthesis and Application of Ratiometric and "Turn-On" Fluorescent pH Sensors: An Advanced Organic Undergraduate Laboratory

    ERIC Educational Resources Information Center

    Hutt, Johnathon T.; Aron, Zachary D.

    2014-01-01

    An upper-division organic chemistry laboratory experiment exploring fluorescent sensing over two laboratory periods and part of a third is described. Two functionally distinct pH-responsive sensors are prepared through a dehydrative three-component coupling reaction. During the abbreviated (<1 h) first laboratory period, students set up…

  4. Ribose 5-Phosphate Isomerase Investigations for the Undergraduate Biochemistry Laboratory

    ERIC Educational Resources Information Center

    Jewett, Kathy; Sandwick, Roger K.

    2011-01-01

    The enzyme ribose 5-phosphate isomerase (RpiA) has many features that make it attractive as a focal point of a semester-long, advanced biochemistry laboratory for undergraduate students. The protein can easily and inexpensively be isolated from spinach using traditional purification techniques. Characterization of RpiA enzyme activity can be…

  5. Genomics and Bioinformatics in Undergraduate Curricula: Contexts for Hybrid Laboratory/Lecture Courses for Entering and Advanced Science Students

    ERIC Educational Resources Information Center

    Temple, Louise; Cresawn, Steven G.; Monroe, Jonathan D.

    2010-01-01

    Emerging interest in genomics in the scientific community prompted biologists at James Madison University to create two courses at different levels to modernize the biology curriculum. The courses are hybrids of classroom and laboratory experiences. An upper level class uses raw sequence of a genome (plasmid or virus) as the subject on which to…

  6. Synthesis and Multinuclear Lanthanide Shift Reagent NMR Analysis of 1- and 2-Adamantanol: An Advanced Undergraduate Laboratory Project.

    ERIC Educational Resources Information Center

    Schaeffer, Charles D., Jr.; Yoder, Claude H.

    1985-01-01

    Reports on a project used in a junior-level laboratory in which students prepare two alcohols, characterize these compounds, and use a shift reagent for structure determination and peak assignment. Background information, materials needed, procedures used, and typical results obtained are included. (JN)

  7. Undergraduate Organic Chemistry Laboratory Safety

    NASA Astrophysics Data System (ADS)

    Luckenbaugh, Raymond W.

    1996-11-01

    Each organic chemistry student should become familiar with the educational and governmental laboratory safety requirements. One method for teaching laboratory safety is to assign each student to locate safety resources for a specific class laboratory experiment. The student should obtain toxicity and hazardous information for all chemicals used or produced during the assigned experiment. For example, what is the LD50 or LC50 for each chemical? Are there any specific hazards for these chemicals, carcinogen, mutagen, teratogen, neurotixin, chronic toxin, corrosive, flammable, or explosive agent? The school's "Chemical Hygiene Plan", "Prudent Practices for Handling Hazardous Chemicals in the Laboratory" (National Academy Press), and "Laboratory Standards, Part 1910 - Occupational Safety and Health Standards" (Fed. Register 1/31/90, 55, 3227-3335) should be reviewed for laboratory safety requirements for the assigned experiment. For example, what are the procedures for safe handling of vacuum systems, if a vacuum distillation is used in the assigned experiment? The literature survey must be submitted to the laboratory instructor one week prior to the laboratory session for review and approval. The student should then give a short presentation to the class on the chemicals' toxicity and hazards and describe the safety precautions that must be followed. This procedure gives the student first-hand knowledge on how to find and evaluate information to meet laboartory safety requirements.

  8. Laser Mode Structure Experiments for Undergraduate Laboratories.

    ERIC Educational Resources Information Center

    Phillips, Richard A.; Gehrz, Robert D.

    Experiments dealing with laser mode structure are presented which are suitable for an upper division undergraduate laboratory. The theory of cavity modes is summarized. The mode structure of the radiation from a helium-neon laser is measured by using a photodiode detector and spectrum analyzer to detect intermode beating. Off-axial modes can be…

  9. Environmental Chemistry in the Undergraduate Laboratory.

    ERIC Educational Resources Information Center

    Wenzel, Thomas J.; Austin, Rachel N.

    2001-01-01

    Discusses the importance of environmental chemistry and the use of laboratory exercises in analytical and general chemistry courses. Notes the importance of lab work in heightening student interest in coursework including problem-based learning in undergraduate curricula, ready adaptability of environmental coursework to existing curricula, and…

  10. A Mechanical Resonance Apparatus for Undergraduate Laboratories.

    ERIC Educational Resources Information Center

    Jones, Christopher C.

    1995-01-01

    Reports the use of a heavy duty hacksaw blade and a 1000 turn pick-up coil to form the basis of a mechanical oscillator for a laboratory exercise in mechanical resonance designed for either the elementary undergraduate course or in association with an upper level mechanics course. (LZ)

  11. Digital Storage Oscilloscopes in the Undergraduate Laboratory

    ERIC Educational Resources Information Center

    Kraftmakher, Yaakov

    2012-01-01

    Digital storage oscilloscopes (DSOs) are now easily available to undergraduate laboratories. In many cases, a DSO can replace a data-acquisition system. Seven such experiments/demonstrations are considered: (i) families of "I-V" characteristics of electronic devices (bipolar junction transistor), (ii) the "V-I" curve of a high-temperature…

  12. Guaiacol Peroxidase Zymography for the Undergraduate Laboratory

    ERIC Educational Resources Information Center

    Wilkesman, Jeff; Castro, Diana; Contreras, Lellys M.; Kurz, Liliana

    2014-01-01

    This laboratory exercise presents a novel way to introduce undergraduate students to the specific detection of enzymatic activity by electrophoresis. First, students prepare a crude peroxidase extract and then analyze the homogenate via electrophoresis. Zymography, that is, a SDS-PAGE method to detect enzyme activity, is used to specifically…

  13. Undergraduate students' goals for chemistry laboratory coursework

    NASA Astrophysics Data System (ADS)

    DeKorver, Brittland K.

    Chemistry laboratory coursework has the potential to offer many benefits to students, yet few of these learning goals are realized in practice. Therefore, this study seeks to characterize undergraduate students' learning goals for their chemistry laboratory coursework. Data were collected by recording video of students completing laboratory experiments and conducting interviews with the students about their experiences that were analyzed utilizing the frameworks of Human Constructivism and Self-Regulated Learning. A cross-sectional sampling of students allowed comparisons to be made among students with varying levels of chemistry experience and interest in chemistry. The student goals identified by this study were compared to previously described laboratory learning goals of the faculty who instruct these courses in an effort to identify potential avenues to improve laboratory learning.

  14. Teaching Writing Skills in the Undergraduate Laboratory

    NASA Astrophysics Data System (ADS)

    Ugolini, Dennis W.

    1998-04-01

    Stanford University's Writing in the Major program (WIM) requires every undergraduate degree program to include a writing course specific to its field of study. In the physics department's WIM course, undergraduates learn writing skills by composing laboratory reports in the form of journal articles. While studying such topics as scintillation and population inversion, students also practice techniques for communicating the physics more effectively. Students learn how to select a thesis, organize a complex argument, write concisely, aim their content at the proper audience, prove their assertions, and revise a finished draft. Through clearer writing, students reach a clearer understanding of the physics, and the improvements in both understanding and communication stay with the students through later courses and into their graduate studies. Teaching assistants for the course also notice a marked improvement in their own writing skills.

  15. Berkeley's Advanced Labs for Undergraduate Astronomy Majors

    NASA Astrophysics Data System (ADS)

    Heiles, C.

    1998-12-01

    We currently offer three advanced laboratory courses for undergraduate majors: optical, IR, and radio. These courses contain both intellectual and practical content; in this talk we focus on the radio lab as a representative example. The first half of the semester concentrates on fundamentals of microwave electronics and radio astronomy techniques in four formal laboratory exercises which emphasize hands-on use of microwave devices, laboratory instruments, and computer-controlled data taking. The second half of the course emphasizes astronomy, using a horn with ~ 1 m(2) aperture to map the HI in the Galaxy and a two-element interferometer composed of ~ 1 m diameter dishes on a ~ 10 m baseline to measure accurate positions of radio sources and accurate diameters for the Sun and Moon. These experiments and observations offer ideal opportunities for teaching coordinates, time, rotation matrices, data reduction techniques, least squares, signal processing, image processing, Fourier transforms, and laboratory and astronomical instrumentation. The students can't get along without using computers as actually used by astronomers. We stay away from packaged software such as IRAF, which are ``black boxes''; rather, students learn far more by writing their own software, usually for the first time. They use the IDL language to take and reduce data and prepare them for the lab reports. We insist on quality reports---including tables, postscript graphs and images, correct grammar, spelling, and all the rest---and we strongly urge (successfully!) the students to use LATEX. The other two lab courses have the same emphasis: the guiding spirit is to place the students in a real-life research-like situation. There is too much to do, so students perform the work in small groups of 3 or 4 and groups are encouraged to share their knowledge. Lab reports are written individually. These courses are very demanding, requiring an average of 20 hours per week from the students (and probably

  16. Undergraduate physics laboratory: Electrophoresis in chromatography paper

    NASA Astrophysics Data System (ADS)

    Hyde, Alexander; Batishchev, Oleg

    2015-12-01

    An experiment studying the physical principles of electrophoresis in liquids was developed for an undergraduate laboratory. We have improved upon the standard agarose gel electrophoresis experimental regime with a straightforward and cost-effective procedure, in which drops of widely available black food coloring were separated by electric field into their dye components on strips of chromatography paper soaked in a baking soda/water solution. Terminal velocities of seven student-safe dyes were measured as a function of the electric potential applied along the strips. The molecular mobility was introduced and calculated by analyzing data for a single dye. Sources of systematic and random errors were investigated.

  17. Design and Implementation of an Undergraduate Laboratory Course in Psychophysiology

    ERIC Educational Resources Information Center

    Thibodeau, Ryan

    2011-01-01

    Most psychology curricula require the completion of coursework on the physiological bases of behavior. However, delivery of this critical content in a laboratory format is somewhat rare at the undergraduate level. To fill this gap, this article describes the design and implementation of an undergraduate laboratory course in psychophysiology at a…

  18. Spectroscopic Instrumentation in Undergraduate Astronomy Laboratories

    NASA Astrophysics Data System (ADS)

    Ludovici, Dominic; Mutel, Robert Lucien; Lang, Cornelia C.

    2017-01-01

    We have designed and built two spectrographs for use in undergraduate astronomy laboratories at the University of Iowa. The first, a low cost (appx. $500) low resolution (R ~ 150 - 300) grating-prism (grism) spectrometer consists of five optical elements and is easily modified to other telescope optics. The grism spectrometer is designed to be used in a modified filter wheel. This type of spectrometer allows students to undertake projects requiring sensitive spectral measurements, such as determining the redshifts of quasars. The second instrument is a high resolution (R ~ 8000), moderate cost (appx. $5000) fiber fed echelle spectrometer. The echelle spectrometer will allow students to conduct Doppler measurements such as those used to study spectroscopic binaries. Both systems are designed to be used with robotic telescope systems. The availability of 3D printing enables both of these spectrographs to be constructed in hands-on instrumentation courses where students build and commission their own instruments. Additionally, these instruments enable introductory majors and non-majors laboratory students to gain experience conducting their own spectroscopic observations.

  19. Development of Research Projects in Advanced Laboratory

    NASA Astrophysics Data System (ADS)

    Yu, Ping; Guha, Suchi

    2008-04-01

    Advanced laboratory serves as a bridge spanning primary physics laboratory and scientific research or industrial activities for undergraduate students. Students not only study modern physics experiments and techniques but also acquire the knowledge of advanced instrumentation. It is of interest to encourage students using the knowledge into research projects at a later stage of the course. We have designed several scientific projects for advanced laboratory to promote student's abilities of independent research. Students work as a team to select the project and search literatures, to perform experiments, and to give presentations. During the research project, instructor only provides necessary equipment for the project without any pre-knowledge of results, giving students a real flavor of scientific research. Our initial attempt has shown some interesting results. We found that students showed a very strong motivation in these projects, and student performances exceeded our expectation. Almost all the students in our first batch of the course have now joined graduate school in Physics and Materials Science. In the future we will also arrange graduate students working with undergraduate students to build a collaborative environment. In addition, a more comprehensive method will be used to evaluate student achievements.

  20. Digital holography system for undergraduate student laboratory

    NASA Astrophysics Data System (ADS)

    Buranasiri, P.; Plaipichit, S.; Yindeesuk, W.; Yoshimori, K.

    2015-07-01

    In this paper, we discuss the digital holography (DH) experiment in our optical and communication laboratory course for undergraduate students at Physics department, KMITL. The purposes of DH experiment are presenting our students the meaning and advantage of DH and its applications. The Gabor configurations of in-line DH has been set up for recording a number of samples, which were placed on different distances, simultaneously. Then, the images of all objects have been numerical reconstructed by using computer. The students have been learned that all of reconstructed images have been got from only one time recording, while using the conventional recording technique, sharp images of different objects have been gotten from different recording time. The students also have been learned how to use DH technique for investigation some different kinds of samples on their own of interested such as a human hair or a fingerprint. In our future work, our DH system will be developed to be a portable apparatus for easily showing to children in different areas.

  1. Undergraduate Laboratory Exercises Specific to Food Spoilage Microbiology

    ERIC Educational Resources Information Center

    Snyder, Abigail B.; Worobo, Randy W.; Orta-Ramirez, Alicia

    2016-01-01

    Food spoilage has an enormous economic impact, and microbial food spoilage plays a significant role in food waste and loss; subsequently, an equally significant portion of undergraduate food microbiology instruction should be dedicated to spoilage microbiology. Here, we describe a set of undergraduate microbiology laboratory exercises that focus…

  2. Development of an advanced undergraduate course in acoustics

    NASA Astrophysics Data System (ADS)

    Gee, Kent L.; Neilsen, Tracianne B.; Sommerfeldt, Scott D.

    2016-03-01

    Within many physics undergraduate programs, acoustics is given only a cursory treatment, usually within an introductory course. Because acoustics is a natural vehicle for students to develop intuition about wave phenomena, an advanced undergraduate acoustics course has been developed at Brigham Young University. Although it remains an elective course, enrollment has increased steadily since its inception. The course has been taken by students in physics, applied physics, physics teaching, and mechanical and electrical engineering. In addition to providing training for students motivated by interest in undergraduate research, internship, employment, and graduate schooling opportunities in acoustics, the course facilitates connections between various areas of physics. Explicit connections are made to mechanics, electricity and magnetism, thermodynamics, optics, quantum mechanics, and experimental and computational laboratory courses. Active learning is emphasized through Just-in-Time-Teaching and course structure. Homework exercises are both theoretical and practical and often require making and interpreting of graphs. For example, students may model traffic noise as a series of uncorrelated monopoles or examine highway barrier effectiveness using Fresnel diffraction techniques. Additionally, students participate in resumé-building measurements and learn to report their results in the form of technical memoranda. Course evaluations and post-graduation student surveys rate it among the most valuable undergraduate student courses offered.

  3. Measuring Dynamic Kidney Function in an Undergraduate Physiology Laboratory

    ERIC Educational Resources Information Center

    Medler, Scott; Harrington, Frederick

    2013-01-01

    Most undergraduate physiology laboratories are very limited in how they treat renal physiology. It is common to find teaching laboratories equipped with the capability for high-resolution digital recordings of physiological functions (muscle twitches, ECG, action potentials, respiratory responses, etc.), but most urinary laboratories still rely on…

  4. Undergraduate Skills Laboratories at Sonoma State University

    NASA Astrophysics Data System (ADS)

    Gill, Amandeep; Zack, K.; Mills, H.; Cunningham, B.; Jackowski, S.

    2014-01-01

    Due to the current economic climate, funding sources for many laboratory courses have been cut from university budgets. However, it is still necessary for undergraduates to master laboratory skills to be prepared and competitive applicants when entering the professional world and/or graduate school. In this context, student-led programs may be able to compensate for this lack of formal instruction and reinforce concepts from lecture by applying research techniques to develop hands-on comprehension. The Sonoma State University Chapter of Society of Physics Students has established a peer-led skills lab to teach research techniques in the fields of astronomy and physics. The goal is to alleviate the pressures of both independently learning and efficiently applying techniques to junior and senior-level research projects. These skill labs are especially valuable for nontraditional students who, due to work or family duties, may not get a chance to fully commit to research projects. For example, a topic such as Arduino programming has a multitude of applications in both astronomy and physics, but is not taught in traditional university courses. Although some programming and electronics skills are taught in (separate) classes, they are usually not applied to actual research projects, which combined expertise is needed. For example, in astronomy, there are many situations involving programming telescopes and taking data with electronic cameras. Often students will carry out research using these tools but when something goes wrong, the students will not have the skills to trouble shoot and fix the system. Another astronomical topic to be taught in the skills labs is the analysis of astronomical data, including running remote telescopes, analyzing photometric variability, and understanding the concepts of star magnitudes, flat fields, and biases. These workshops provide a setting in which the student teacher may strengthen his or her understanding of the topic by presenting

  5. Introducing Undergraduates to a Research Laboratory

    ERIC Educational Resources Information Center

    Weinberg, Robert

    1974-01-01

    Discusses a student project which is intended to teach undergraduates concepts and techniques of nuclear physics, experimental methods used in particle detection, and provide experience in a functioning research environment. Included are detailed procedures for carrying out the project. (CC)

  6. Forensic Analysis of Canine DNA Samples in the Undergraduate Biochemistry Laboratory

    ERIC Educational Resources Information Center

    Carson, Tobin M.; Bradley, Sharonda Q.; Fekete, Brenda L.; Millard, Julie T.; LaRiviere, Frederick J.

    2009-01-01

    Recent advances in canine genomics have allowed the development of highly distinguishing methods of analysis for both nuclear and mitochondrial DNA. We describe a laboratory exercise suitable for an undergraduate biochemistry course in which the polymerase chain reaction is used to amplify hypervariable regions of DNA from dog hair and saliva…

  7. Creating a Research-Rich Chemistry Curriculum with an Integrated, Upper-Level-Undergraduate Laboratory Program

    ERIC Educational Resources Information Center

    Gron, Liz U.; Hales, David A.; Teague, M. Warfield

    2007-01-01

    A new research-rich chemistry curriculum with an integrated, upper-level undergraduate laboratory program has recently been developed to impart better understanding to the students. The program is called Advanced techniques in Experimental Chemistry and helps prepare students for more real-world problems.

  8. Simple & Rapid Generation of Complex DNA Profiles for the Undergraduate Laboratory

    ERIC Educational Resources Information Center

    Kass, David H.

    2007-01-01

    Deoxyribonucleic acid (DNA) profiles can be generated by a variety of techniques incorporating different types of DNA markers. Simple methods are commonly utilized in the undergraduate laboratory, but with certain drawbacks. In this article, the author presents an advancement of the "Alu" dimorphism technique involving two tetraplex polymerase…

  9. Kinetics of Carbaryl Hydrolysis: An Undergraduate Environmental Chemistry Laboratory

    ERIC Educational Resources Information Center

    Hawker, Darryl

    2015-01-01

    Kinetics is an important part of undergraduate environmental chemistry curricula and relevant laboratory exercises are helpful in assisting students to grasp concepts. Such exercises are also useful in general chemistry courses because students can see relevance to real-world issues. The laboratory exercise described here involves determination of…

  10. Measuring Stellar Temperatures: An Astrophysical Laboratory for Undergraduate Students

    ERIC Educational Resources Information Center

    Cenadelli, D.; Zeni, M.

    2008-01-01

    While astrophysics is a fascinating subject, it hardly lends itself to laboratory experiences accessible to undergraduate students. In this paper, we describe a feasible astrophysical laboratory experience in which the students are guided to take several stellar spectra, using a telescope, a spectrograph and a CCD camera, and perform a full data…

  11. Information Management Systems in the Undergraduate Instrumental Analysis Laboratory.

    ERIC Educational Resources Information Center

    Merrer, Robert J.

    1985-01-01

    Discusses two applications of Laboratory Information Management Systems (LIMS) in the undergraduate laboratory. They are the coulometric titration of thiosulfate with electrogenerated triiodide ion and the atomic absorption determination of calcium using both analytical calibration curve and standard addition methods. (JN)

  12. An Undergraduate Nanotechnology Engineering Laboratory Course on Atomic Force Microscopy

    ERIC Educational Resources Information Center

    Russo, D.; Fagan, R. D.; Hesjedal, T.

    2011-01-01

    The University of Waterloo, Waterloo, ON, Canada, is home to North America's first undergraduate program in nanotechnology. As part of the Nanotechnology Engineering degree program, a scanning probe microscopy (SPM)-based laboratory has been developed for students in their fourth year. The one-term laboratory course "Nanoprobing and…

  13. EDITORIAL: Student undergraduate laboratory and project work

    NASA Astrophysics Data System (ADS)

    Schumacher, Dieter

    2007-05-01

    that new experiments which illustrate both fundamental physics and modern technology can be realized even with a small budget. Traditional labwork courses often provide a catalogue of well known experiments. The students must first learn the theoretical background. They then assemble the setup from specified equipment, collect the data and perform the default data processing. However, there is no way to learn to swim without water. In order to achieve a constructivist access to learning, 'project labs' are needed. In a project labwork course a small group of students works as a team on a mini research project. The students have to specify the question of research, develop a suitable experimental setup, conduct the experiment and find a suitable way to evaluate the data. Finally they must present their results e.g. in the framework of a public poster session. Three contributions refer to this approach, however they focus on different aspects: 'Project laboratory for first-year students' by Gorazd Planinšič, 'RealTime Physics: active learning laboratories' by David Sokoloff et al and 'Labs outside labs: miniprojects at a spring camp for future physics teachers' by Leos Dvorák. Is it possible to prepare the students specifically for project labwork? This question is answered by the contribution 'A new labwork course for physics students: devices, methods and research projects' by Knut Neumann and Manuela Welzel. The two main parts of the labwork course cover first experimental devices (e.g. multimeters, oscilloscopes, different sensors, operational amplifiers, step motors, AD/DA-converters). Then subjects such as data processing, consideration of measurement uncertainties, keeping records or using tools like LABVIEW etc are focused on. Another concrete proposal for a new curriculum is provided by James Sharp et al, in 'Computer based learning in an undergraduate physics laboratory: interfacing and instrument control using MATLAB'. One can well imagine that project labs

  14. Synthesis of a Self-Healing Polymer Based on Reversible Diels-Alder Reaction: An Advanced Undergraduate Laboratory at the Interface of Organic Chemistry and Materials Science

    ERIC Educational Resources Information Center

    Weizman, Haim; Nielsen, Christian; Weizman, Or S.; Nemat-Nasser, Sia

    2011-01-01

    This laboratory experiment exposes students to the chemistry of self-healing polymers based on a Diels-Alder reaction. Students accomplish a multistep synthesis of a monomer building block and then polymerize it to form a cross-linked polymer. The healing capability of the polymer is verified by differential scanning calorimetry (DSC) experiments.…

  15. Measuring meaningful learning in the undergraduate chemistry laboratory

    NASA Astrophysics Data System (ADS)

    Galloway, Kelli R.

    The undergraduate chemistry laboratory has been an essential component in chemistry education for over a century. The literature includes reports on investigations of singular aspects laboratory learning and attempts to measure the efficacy of reformed laboratory curriculum as well as faculty goals for laboratory learning which found common goals among instructors for students to learn laboratory skills, techniques, experimental design, and to develop critical thinking skills. These findings are important for improving teaching and learning in the undergraduate chemistry laboratory, but research is needed to connect the faculty goals to student perceptions. This study was designed to explore students' ideas about learning in the undergraduate chemistry laboratory. Novak's Theory of Meaningful Learning was used as a guide for the data collection and analysis choices for this research. Novak's theory states that in order for meaningful learning to occur the cognitive, affective, and psychomotor domains must be integrated. The psychomotor domain is inherent in the chemistry laboratory, but the extent to which the cognitive and affective domains are integrated is unknown. For meaningful learning to occur in the laboratory, students must actively integrate both the cognitive domain and the affective domains into the "doing" of their laboratory work. The Meaningful Learning in the Laboratory Instrument (MLLI) was designed to measure students' cognitive and affective expectations and experiences within the context of conducting experiments in the undergraduate chemistry laboratory. Evidence for the validity and reliability of the data generated by the MLLI were collected from multiple quantitative studies: a one semester study at one university, a one semester study at 15 colleges and universities across the United States, and a longitudinal study where the MLLI was administered 6 times during two years of general and organic chemistry laboratory courses. Results from

  16. Safety Concepts for Undergraduate Chemistry Laboratories.

    ERIC Educational Resources Information Center

    Chlad, Frank L.; Hardy, James K.

    1983-01-01

    Safety procedures used by Department of Chemistry at the University of Akron are discussed. These include policy that no chemicals are stored in the teaching laboratories. Instead, dispensing stockrooms are used to service the laboratories. Other aspects discussed include ventilation procedures and development of microprocessor use in stockrooms.…

  17. Making Connections in the Undergraduate Laboratory.

    ERIC Educational Resources Information Center

    Poole, Bobbie J.; Kidder, Stanley Q.

    1996-01-01

    Describes a strategy used in a meteorology course to increase its relevance to students' lives. Involves combining the lecture and laboratory portions of the course and including a Connections section in the lab report in which students comment on the connections they saw between the coursework, the laboratory exercises, and their own experience.…

  18. Undergraduate Laboratory Module on Skin Diffusion

    ERIC Educational Resources Information Center

    Norman, James J.; Andrews, Samantha N.; Prausnitz, Mark R.

    2011-01-01

    To introduce students to an application of chemical engineering directly related to human health, we developed an experiment for the unit operations laboratory at Georgia Tech examining diffusion across cadaver skin in the context of transdermal drug delivery. In this laboratory module, students prepare mouse skin samples, set up diffusion cells…

  19. Advanced interdisciplinary undergraduate program: light engineering

    NASA Astrophysics Data System (ADS)

    Bakholdin, Alexey; Bougrov, Vladislav; Voznesenskaya, Anna; Ezhova, Kseniia

    2016-09-01

    The undergraduate educational program "Light Engineering" of an advanced level of studies is focused on development of scientific learning outcomes and training of professionals, whose activities are in the interdisciplinary fields of Optical engineering and Technical physics. The program gives practical experience in transmission, reception, storage, processing and displaying information using opto-electronic devices, automation of optical systems design, computer image modeling, automated quality control and characterization of optical devices. The program is implemented in accordance with Educational standards of the ITMO University. The specific features of the Program is practice- and problem-based learning implemented by engaging students to perform research and projects, internships at the enterprises and in leading Russian and international research educational centers. The modular structure of the Program and a significant proportion of variable disciplines provide the concept of individual learning for each student. Learning outcomes of the program's graduates include theoretical knowledge and skills in natural science and core professional disciplines, deep knowledge of modern computer technologies, research expertise, design skills, optical and optoelectronic systems and devices.

  20. Chemical Reaction Experiment for the Undergraduate Laboratory.

    ERIC Educational Resources Information Center

    Kwon, K. C.; And Others

    1987-01-01

    Provides an overview of an experiment on reaction kinetics of the anthracene-hydrogen system. Includes a description of the laboratory equipment, procedures, and data analysis requirements. Points out the advantages of the recommended technique. (ML)

  1. Magnetic Braking Revisited: Activities for the Undergraduate Laboratory

    ERIC Educational Resources Information Center

    Ireson, Gren; Twidle, John

    2008-01-01

    This paper revisits the demonstration of Lenz by dropping magnets down a non-magnetic tube. Recent publications are reviewed and ideas for undergraduate laboratory investigations are suggested. Finally, an example of matching theory to observation is presented. (Contains 4 tables, 5 figures and 3 footnotes.)

  2. Synthesis and Characterization of Silver Nanoparticles for an Undergraduate Laboratory

    ERIC Educational Resources Information Center

    Orbaek, Alvin W.; McHale, Mary M.; Barron, Andrew R.

    2015-01-01

    The aim of this simple, quick, and safe laboratory exercise is to provide undergraduate students an introduction to nanotechnology using nanoparticle (NP) synthesis. Students are provided two procedures that allow for the synthesis of different yet controlled sizes of silver NPs. After preparing the NPs, the students perform UV-visible…

  3. An Integrated Enzyme Kinetics Laboratory Sequence for Undergraduates.

    ERIC Educational Resources Information Center

    Bucholtz, Michael L.

    1988-01-01

    Describes a three-week sequence to take undergraduate students through the study of enzyme kinetics in an integrated manner that reinforces the basic concepts of initial velocity and the effects of varying operational parameters. Discusses laboratory sessions and the use of a microcomputer in instruction. (CW)

  4. An Undergraduate Laboratory Exercise for Studying Kinetics of Batch Crystallization

    ERIC Educational Resources Information Center

    Louhi­-Kultanen, Marjatta; Han, Bing; Nurkka, Annikka; Hatakka, Henry

    2015-01-01

    The present work describes an undergraduate laboratory exercise for improving understanding of fundamental phenomena in cooling crystallization. The exercise of nucleation and crystal growth kinetics supports learning of theories and models presented in lectures and calculation exercises. The teaching methodology incorporates precepts the…

  5. Field Research Studying Whales in an Undergraduate Animal Behavior Laboratory

    ERIC Educational Resources Information Center

    MacLaren, R. David; Schulte, Dianna; Kennedy, Jen

    2012-01-01

    This work describes a new field research laboratory in an undergraduate animal behavior course involving the study of whale behavior, ecology and conservation in partnership with a non-profit research organization--the Blue Ocean Society for Marine Conservation (BOS). The project involves two weeks of training and five weekend trips on whale watch…

  6. Outcomes of a Research-Driven Laboratory and Literature Course Designed to Enhance Undergraduate Contributions to Original Research

    ERIC Educational Resources Information Center

    Rasche, Madeline E.

    2004-01-01

    This work describes outcomes of a research-driven advanced microbiology laboratory and literature research course intended to enhance undergraduate preparation for and contributions to original research. The laboratory section was designed to teach fundamental biochemistry and molecular biology techniques in the context of an original research…

  7. Undergraduate Laboratory Data Acquisition With a Microcomputer.

    ERIC Educational Resources Information Center

    Weston, Kenneth C.

    1981-01-01

    Describes a flexible, multichannel, highly accurate, digital data acquisition system for use with a microcomputer. Includes a description of instrumentation for computer data acquisition, data acquisition systems, software, uses in the curriculum, library interaction and action, and use in a mechanical engineering laboratory. (DS)

  8. Microcomputers in an Undergraduate Optics Laboratory.

    ERIC Educational Resources Information Center

    Tomaselli, V. P.; And Others

    1990-01-01

    Describes a junior-level, one-year optics laboratory course for physics and engineering students. The course offers a range of experiments from conventional geometric optics to contemporary spatial filtering and fiber optics. Presents an example of an experiment with pictures. (Author/YP)

  9. Basic neuron model electrical equivalent circuit: an undergraduate laboratory exercise.

    PubMed

    Dabrowski, Katie M; Castaño, Diego J; Tartar, Jaime L

    2013-01-01

    We developed a hands-on laboratory exercise for undergraduate students in which they can build and manipulate a neuron equivalent circuit. This exercise uses electrical circuit components that resemble neuron components and are easy to construct. We describe the methods for creating the equivalent circuit and how to observe different neuron properties through altering the structure of the equivalent circuit. We explain how this hands-on laboratory activity allows for the better understanding of this fundamental neuroscience concept. At the conclusion of this laboratory exercise, undergraduate students will be able to apply the principles of Ohm's law, cable theory with regards to neurons, and understand the functions of resistance and capacitance in a neuron.

  10. Characterizing Instructional Practices in the Laboratory: The Laboratory Observation Protocol for Undergraduate STEM

    ERIC Educational Resources Information Center

    Velasco, Jonathan B.; Knedeisen, Adam; Xue, Dihua; Vickrey, Trisha L.; Abebe, Marytza; Stains, Marilyne

    2016-01-01

    Chemistry laboratories play an essential role in the education of undergraduate Science, Technology, Engineering, and Mathematics (STEM) and non-STEM students. The extent of student learning in any educational environment depends largely on the effectiveness of the instructors. In chemistry laboratories at large universities, the instructors of…

  11. Measuring dynamic kidney function in an undergraduate physiology laboratory.

    PubMed

    Medler, Scott; Harrington, Frederick

    2013-12-01

    Most undergraduate physiology laboratories are very limited in how they treat renal physiology. It is common to find teaching laboratories equipped with the capability for high-resolution digital recordings of physiological functions (muscle twitches, ECG, action potentials, respiratory responses, etc.), but most urinary laboratories still rely on a "dipstick" approach of urinalysis. Although this technique can provide some basic insights into the functioning of the kidneys, it overlooks the dynamic processes of filtration, reabsorption, and secretion. In the present article, we provide a straightforward approach of using renal clearance measurements to estimate glomerular filtration rate, fractional water reabsorption, glucose clearance, and other physiologically relevant parameters. The estimated values from our measurements in laboratory are in close agreement with those anticipated based on textbook parameters. For example, we found glomerular filtration rate to average 124 ± 45 ml/min, serum creatinine to be 1.23 ± 0.4 mg/dl, and fractional water reabsorption to be ∼96.8%. Furthermore, analyses for the class data revealed significant correlations between parameters like fractional water reabsorption and urine concentration, providing opportunities to discuss urine concentrating mechanisms and other physiological processes. The procedures outlined here are general enough that most undergraduate physiology laboratory courses should be able to implement them without difficulty.

  12. Video Episodes and Action Cameras in the Undergraduate Chemistry Laboratory: Eliciting Student Perceptions of Meaningful Learning

    ERIC Educational Resources Information Center

    Galloway, Kelli R.; Bretz, Stacey Lowery

    2016-01-01

    A series of quantitative studies investigated undergraduate students' perceptions of their cognitive and affective learning in the undergraduate chemistry laboratory. To explore these quantitative findings, a qualitative research protocol was developed to characterize student learning in the undergraduate chemistry laboratory. Students (N = 13)…

  13. A Virtual Embedded Microcontroller Laboratory for Undergraduate Education: Development and Evaluation

    ERIC Educational Resources Information Center

    Richardson, Jeffrey J.; Adamo-Villani, Nicoletta

    2010-01-01

    Laboratory instruction is a major component of the engineering and technology undergraduate curricula. Traditional laboratory instruction is hampered by several factors including limited access to resources by students and high laboratory maintenance cost. A photorealistic 3D computer-simulated laboratory for undergraduate instruction in…

  14. An Undergraduate Laboratory Exercise to Study Weber’s Law

    PubMed Central

    Holden, Jameson K.; Francisco, Eric M.; Zhang, Zheng; Baric, Cristina; Tommerdahl, Mark

    2011-01-01

    Weber’s Law describes the relationship between actual and perceived differences in stimulus intensity. To observe the relationship described in this law, we developed an exercise for undergraduate students, as experiential learning is an integral part of scientific education. We describe the experimental methods used for determining the subject’s discriminative capacity at multiple vibrotactile amplitudes. A novel four-point stimulator (designed and fabricated at the University of North Carolina) was used for the study. Features of the device, such as automated skin detection, make it feasible to perform this laboratory exercise in a reasonable lab period. At the conclusion of the lab exercise, students will thoroughly understand the principle of Weber’s Law as well as fundamental quantitative sensory testing concepts. This introduction to sensory testing will provide a suitable foundation for the undergraduate neuroscience student to investigate other aspects of sensory information processing in subsequent lab exercises. PMID:23493843

  15. Blended learning within an undergraduate exercise physiology laboratory.

    PubMed

    Elmer, Steven J; Carter, Kathryn R; Armga, Austin J; Carter, Jason R

    2016-03-01

    In physiological education, blended course formats (integration of face-to-face and online instruction) can facilitate increased student learning, performance, and satisfaction in classroom settings. There is limited evidence on the effectiveness of using blending course formats in laboratory settings. We evaluated the impact of blended learning on student performance and perceptions in an undergraduate exercise physiology laboratory. Using a randomized, crossover design, four laboratory topics were delivered in either a blended or traditional format. For blended laboratories, content was offloaded to self-paced video demonstrations (∼15 min). Laboratory section 1 (n = 16) completed blended laboratories for 1) neuromuscular power and 2) blood lactate, whereas section 2 (n = 17) completed blended laboratories for 1) maximal O2 consumption and 2) muscle electromyography. Both sections completed the same assignments (scored in a blinded manner using a standardized rubric) and practicum exams (evaluated by two independent investigators). Pre- and postcourse surveys were used to assess student perceptions. Most students (∼79%) watched videos for both blended laboratories. Assignment scores did not differ between blended and traditional laboratories (P = 0.62) or between sections (P = 0.91). Practicum scores did not differ between sections (both P > 0.05). At the end of the course, students' perceived value of the blended format increased (P < 0.01) and a greater percentage of students agreed that learning key foundational content through video demonstrations before class greatly enhanced their learning of course material compared with a preassigned reading (94% vs. 78%, P < 0.01). Blended exercise physiology laboratories provided an alternative method for delivering content that was favorably perceived by students and did not compromise student performance.

  16. Teaching PCR Through Inquiry in an Undergraduate Biology Laboratory Course

    NASA Astrophysics Data System (ADS)

    Dorighi, K. M.; Betancourt, J.; Sapp, J.; Quan, T. K.; Lee, J.

    2010-12-01

    In this paper, we describe the design and implementation of an inquiry-based laboratory unit on the Polymerase Chain Reaction (PCR). This unit was designed and taught for the undergraduate Eukaryotic Genetics Laboratory class (Bio105L) at the University of California, Santa Cruz. Our activity utilizes an authentic molecular biology research question to teach the underlying molecular mechanisms and experimental technique of PCR, as well as fundamental scientific process skills such as planning experiments, making predictions and interpreting data. In particular, the activity prompts students to use PCR to determine which gene has been deleted in a region of the Drosophila genome. During this activity, students also gained technical experience in common molecular biology techniques, learned about additional applications of PCR and used a hands-on approach to model each step of PCR.

  17. Study of Polymer Glasses by Modulated Differential Scanning Calorimetry in the Undergraduate Physical Chemistry Laboratory

    NASA Astrophysics Data System (ADS)

    Folmer, J. C. W.; Franzen, Stefan

    2003-07-01

    Recent technological advances in thermal analysis present educational opportunities. In particular, modulated differential scanning calorimetry (MDSC) can be used to contrast reversing and nonreversing processes in practical laboratory experiments. The introduction of these concepts elucidates the relationship between experimental timescales and reversibility. The latter is a key concept of undergraduate thermodynamics theory that deserves reinforcement. In this paper, the theory and application of MDSC to problems of current interest is outlined with special emphasis on the contrast between crystallization and vitrification. Glass formation deserves greater emphasis in the undergraduate curriculum. Glass transitions are increasingly recognized as an important aspect of materials properties and dynamics in fields ranging from polymer science to protein folding. The example chosen for study is a comparison of polyethylene glycol and atactic polypropylene glycol. The experiment is easily performed in a typical three-hour lab session.

  18. Integration of a Communicating Science Module into an Advanced Chemistry Laboratory Course

    ERIC Educational Resources Information Center

    Renaud, Jessica; Squier, Christopher; Larsen, Sarah C.

    2006-01-01

    A communicating science module was introduced into an advanced undergraduate physical chemistry laboratory course. The module was integrated into the course such that students received formal instruction in communicating science interwoven with the chemistry laboratory curriculum. The content of the communicating science module included three…

  19. Two Crystallographic Laboratory and Computational Exercises for Undergraduates.

    ERIC Educational Resources Information Center

    Lessinger, Leslie

    1988-01-01

    Describes two introductory exercises designed to teach the fundamental ideas and methods of crystallography, and to convey some important features of inorganic and organic crystal structures to students in an advanced laboratory course. Exercises include "The Crystal Structure of NiO" and "The Crystal Structure of Beta-Fumaric Acid." (CW)

  20. Enhancing Scientific Literacy in the Undergraduate Cell Biology Laboratory Classroom†

    PubMed Central

    Woodham, Hadiya; Marbach-Ad, Gili; Downey, Gretchen; Tomei, Erika; Thompson, Katerina

    2016-01-01

    This paper describes the implementation of the Scientific Literacy in Cell Biology (SLCB) curriculum in an undergraduate biology laboratory course. The SLCB curriculum incorporated the reading and discussion of primary literature into hands-on and collaborative practical experiences. It was implemented in five stages over an 11-week period, during which students were also introduced to the theory and practice of common cell biology techniques. We report on the effectiveness of the course, as measured by pre- and post-course survey data probing students’ content knowledge and their level of familiarity, confidence, and experience with different skills pertaining to analyzing (reading, interpreting, and discussing) primary literature. In the spring 2015 semester, 287 (72%) of the 396 students who were enrolled in the laboratory completed both the pre- and post-course survey. The average score on the content questions of the post-course survey was significantly higher (p < 0.0001) than the average score on the pre-course survey. Students reported that they gained greater familiarity, experience, and confidence in the skills that were measured. Our findings may aid in reforming higher-education science laboratory courses to better promote writing, reading, data processing, and presentation skills. Journal of Microbiology & Biology Education PMID:28101274

  1. Status of Undergraduate Pharmacology Laboratories in Colleges of Pharmacy in the United States

    ERIC Educational Resources Information Center

    Katz, Norman L.; And Others

    1978-01-01

    U.S. colleges of pharmacy were surveyed in 1976 to determine whether a trend exists in continuing, discontinuing, or restructuring laboratory time in pharmaceutical education. Data regarding core undergraduate pharmacology courses, undergraduate pharmacology laboratory status, and pharmacology faculty are presented. (LBH)

  2. Faculty Perspectives of Undergraduate Chemistry Laboratory: Goals and Obstacles to Success

    ERIC Educational Resources Information Center

    Bruck, Laura B.; Towns, Marcy; Bretz, Stacey Lowery

    2010-01-01

    Faculty perspectives of the undergraduate chemistry laboratory were the focus of a study to articulate the goals, strategies, and assessments used in undergraduate teaching laboratories. Data were collected via semistructured interviews with faculty (N = 22) from community colleges, liberal arts colleges, comprehensive universities, and research…

  3. Advancing Information and Communication Technology Knowledge for Undergraduate Nursing Students

    PubMed Central

    Procter, Paula M

    2012-01-01

    Nursing is a dynamic profession; for registered nurses their role is increasingly requiring greater information process understanding and the effective management of information to ensure high quality safe patient care. This paper outlines the design and implementation of Systems of eCare. This is a course which advances information and communication technology knowledge for undergraduate nursing students within a Faculty of Health and Wellbeing appropriately preparing nurses for their professional careers. Systems of eCare entwines throughout the three year programme mapping to the curriculum giving meaning to learning for the student. In conclusion comments from students convey their appreciation of the provision of this element of the undergraduate programme. PMID:24199114

  4. Discovery of Escherichia coli CRISPR sequences in an undergraduate laboratory.

    PubMed

    Militello, Kevin T; Lazatin, Justine C

    2016-09-28

    Clustered regularly interspaced short palindromic repeats (CRISPRs) represent a novel type of adaptive immune system found in eubacteria and archaebacteria. CRISPRs have recently generated a lot of attention due to their unique ability to catalog foreign nucleic acids, their ability to destroy foreign nucleic acids in a mechanism that shares some similarity to RNA interference, and the ability to utilize reconstituted CRISPR systems for genome editing in numerous organisms. In order to introduce CRISPR biology into an undergraduate upper-level laboratory, a five-week set of exercises was designed to allow students to examine the CRISPR status of uncharacterized Escherichia coli strains and to allow the discovery of new repeats and spacers. Students started the project by isolating genomic DNA from E. coli and amplifying the iap CRISPR locus using the polymerase chain reaction (PCR). The PCR products were analyzed by Sanger DNA sequencing, and the sequences were examined for the presence of CRISPR repeat sequences. The regions between the repeats, the spacers, were extracted and analyzed with BLASTN searches. Overall, CRISPR loci were sequenced from several previously uncharacterized E. coli strains and one E. coli K-12 strain. Sanger DNA sequencing resulted in the discovery of 36 spacer sequences and their corresponding surrounding repeat sequences. Five of the spacers were homologous to foreign (non-E. coli) DNA. Assessment of the laboratory indicates that improvements were made in the ability of students to answer questions relating to the structure and function of CRISPRs. Future directions of the laboratory are presented and discussed. © 2016 by The International Union of Biochemistry and Molecular Biology, 2016.

  5. Conceptualization, Development and Validation of an Instrument for Investigating Elements of Undergraduate Physics Laboratory Learning Environments: The UPLLES (Undergraduate Physics Laboratory Learning Environment Survey)

    ERIC Educational Resources Information Center

    Thomas, Gregory P; Meldrum, Al; Beamish, John

    2013-01-01

    First-year undergraduate physics laboratories are important physics learning environments. However, there is a lack of empirically informed literature regarding how students perceive their overall laboratory learning experiences. Recipe formats persist as the dominant form of instructional design in these sites, and these formats do not adequately…

  6. ALPhA: The Advanced Laboratory Physics Association

    NASA Astrophysics Data System (ADS)

    Black, Eric; McCann, Lowell; Reichert, Jonathan; Spalding, Gabe; Essick, John; van Baak, David; Wonnell, Steve

    2011-03-01

    The Advanced Laboratory Physics Association (ALPhA) is a group of people with a shared interest in teaching physics labs at the advanced undergraduate or graduate level. ALPhA works closely with the American Physical Society (APS), the Optical Society of America (OSA), and the American Association of Physics Teachers (AAPT) to develop new methods for teaching modern experimental physics. In the summer of 2010 we initiated the ALPhA Immersion Program, a three-day short course where instructors visit a lab, do one or more of the local experiments (home-built or commercial) with the local instructor, and learn the experiments well enough to incorporate them into their own programs. These immersions were very well received, with attendees filling up all available slots. In this talk I will describe ALPhA and the Immersions Program and solicit input from the broader community.

  7. A Curriculum Skills Matrix for Development and Assessment of Undergraduate Biochemistry and Molecular Biology Laboratory Programs

    ERIC Educational Resources Information Center

    Caldwell, Benjamin; Rohlman, Christopher; Benore-Parsons, Marilee

    2004-01-01

    We have designed a skills matrix to be used for developing and assessing undergraduate biochemistry and molecular biology laboratory curricula. We prepared the skills matrix for the Project Kaleidoscope Summer Institute workshop in Snowbird, Utah (July 2001) to help current and developing undergraduate biochemistry and molecular biology program…

  8. Purification and Characterization of Taq Polymerase: A 9-Week Biochemistry Laboratory Project for Undergraduate Students

    ERIC Educational Resources Information Center

    Bellin, Robert M.; Bruno, Mary K.; Farrow, Melissa A.

    2010-01-01

    We have developed a 9-week undergraduate laboratory series focused on the purification and characterization of "Thermus aquaticus" DNA polymerase (Taq). Our aim was to provide undergraduate biochemistry students with a full-semester continuing project simulating a research-like experience, while having each week's procedure focus on a single…

  9. [A Perspective on Innovation for Efficient Medical Practice in View of Undergraduate and Postgraduate Education and Training in Laboratory Medicine].

    PubMed

    Kawai, Tadashi

    2015-10-01

    Continuous advances in medical laboratory technology have driven major changes in the practice of laboratory medicine over the past two decades. The importance of the overall quality of a medical laboratory has been ever-increasing in order to improve and ensure the quality and safety of clinical practice by physicians in any type of medical facility. Laboratory physicians and professional staff should challenge themselves more than ever in various ways to cooperate and contribute with practicing physicians for the appropriate utilization of laboratory testing. This will certainly lead to a decrease in inappropriate or unnecessary laboratory testing, resulting in reducing medical costs. In addition, not only postgraduate, but also undergraduate medical education/training systems must be markedly innovated, considering recent rapid progress in electronic information and communication technologies.

  10. Development of sensorial experiments and their implementation into undergraduate laboratories

    NASA Astrophysics Data System (ADS)

    Bromfield Lee, Deborah Christina

    "Visualization" of chemical phenomena often has been limited in the teaching laboratories to the sense of sight. We have developed chemistry experiments that rely on senses other than eyesight to investigate chemical concepts, make quantitative determinations, and familiarize students with chemical techniques traditionally designed using only eyesight. Multi-sensory learning can benefit all students by actively engaging them in learning through stimulation or an alternative way of experiencing a concept or ideas. Perception of events or concepts usually depends on the information from the different sensory systems combined. The use of multi-sensory learning can take advantage of all the senses to reinforce learning as each sense builds toward a more complete experience of scientific data. Research has shown that multi-sensory representations of scientific phenomena is a valuable tool for enhancing understanding of chemistry as well as displacing misconceptions through experience. Multi-sensory experiences have also been shown to enrich memory performance. There are few experiments published which utilize multiple senses in the teaching laboratory. The sensorial experiments chosen were conceptually similar to experiments currently performed in undergraduate laboratories; however students collect different types of data using multi-sensory observations. The experiments themselves were developed by using chemicals that would provide different sensory changes or capitalizing on sensory observations that were typically overlooked or ignored and obtain similar and precise results as in traditional experiments. Minimizing hazards and using safe practices are especially essential in these experiments as students utilize senses traditionally not allowed to be used in the laboratories. These sensorial experiments utilize typical equipment found in the teaching laboratories as well as inexpensive chemicals in order to aid implementation. All experiments are rigorously tested

  11. Determination of Rate Constants for Ouabain Inhibition of Adenosine Triphosphatase: An Undergraduate Biological Chemistry Laboratory Experiment

    ERIC Educational Resources Information Center

    Sall, Eri; And Others

    1978-01-01

    Describes an undergraduate biological chemistry laboratory experiment which provides students with an example of pseudo-first-order kinetics with the cardiac glycoside inhibition of mammalism sodium and potassium transport. (SL)

  12. The Quartz-Crystal Microbalance in an Undergraduate Laboratory Experiment: I. Fundamentals and Instrumentation

    ERIC Educational Resources Information Center

    Tsionsky, Vladimir

    2007-01-01

    The fundamentals, as well as the instrumentation of the quartz-crystal microbalance (QCM) technique that is used in an undergraduate laboratory experiment are being described. The QCM response can be easily used to change the properties of any system.

  13. A Green Starting Material for Electrophilic Aromatic Substitution for the Undergraduate Organic Laboratory

    ERIC Educational Resources Information Center

    Jones-Wilson, T. Michelle; Burtch, Elizabeth A.

    2005-01-01

    Electrophilic aromatic substitution (EAS) experiment is designed for the second-semester and undergraduate organic chemistry laboratory. In the EAS experiment, the principles of green chemistry are discussed and illustrated in conjunction with the presentation of electrophilic aromatic substitution.

  14. Affinity Chromatography of Lactate Dehydrogenase: An Experiment for the Undergraduate Biochemistry Laboratory.

    ERIC Educational Resources Information Center

    Anderson, Alexander J.

    1988-01-01

    Discusses a laboratory technique of enzyme purification by affinity chromatography as part of an undergraduate biochemical methodology course. Provides preparation details of the rat muscle homogenate and reagents. Proposes column requirements and assaying information. (MVL)

  15. An Experiment Using Sucrose Density Gradients in the Undergraduate Biochemistry Laboratory.

    ERIC Educational Resources Information Center

    Turchi, Sandra L.; Weiss, Monica

    1988-01-01

    Describes an experiment to be performed in an undergraduate biochemistry laboratory that is based on a gradient centrifugation system employing a simple bench top centrifuge, a freezer, and frozen surcose gradient solution to separate macromolecules and subcellular components. (CW)

  16. Screening for Saponins Using the Blood Hemolysis Test. An Undergraduate Laboratory Experiment.

    ERIC Educational Resources Information Center

    Sotheeswaran, Subramaniam

    1988-01-01

    Describes an experiment for undergraduate chemistry laboratories involving a chemical found in plants and some sea animals. Discusses collection and identification of material, a hemolysis test, preparation of blood-coated agar plates, and application of samples. (CW)

  17. Known Structure, Unknown Function: An Inquiry-Based Undergraduate Biochemistry Laboratory Course

    ERIC Educational Resources Information Center

    Gray, Cynthia; Price, Carol W.; Lee, Christopher T.; Dewald, Alison H.; Cline, Matthew A.; McAnany, Charles E.; Columbus, Linda; Mura, Cameron

    2015-01-01

    Undergraduate biochemistry laboratory courses often do not provide students with an authentic research experience, particularly when the express purpose of the laboratory is purely instructional. However, an instructional laboratory course that is inquiry- and research-based could simultaneously impart scientific knowledge and foster a student's…

  18. Measuring Meaningful Learning in the Undergraduate Chemistry Laboratory: A National, Cross-Sectional Study

    ERIC Educational Resources Information Center

    Galloway, Kelli R.; Bretz, Stacey Lowery

    2015-01-01

    Research on laboratory learning points to the need to better understand what and how students learn in the undergraduate chemistry laboratory. The Meaningful Learning in the Laboratory Instrument (MLLI) was administered to general and organic chemistry students from 15 colleges and universities across the United States in order to measure the…

  19. Measuring Meaningful Learning in the Undergraduate General Chemistry and Organic Chemistry Laboratories: A Longitudinal Study

    ERIC Educational Resources Information Center

    Galloway, Kelli R.; Bretz, Stacey Lowery

    2015-01-01

    Understanding how students learn in the undergraduate chemistry teaching laboratory is an essential component to developing evidence-based laboratory curricula. The Meaningful Learning in the Laboratory Instrument (MLLI) was developed to measure students' cognitive and affective expectations and experiences for learning in the chemistry…

  20. 4,5-Diphenyl-1-methylimidazole: An Undergraduate Laboratory Experiment.

    ERIC Educational Resources Information Center

    Anastas, Paul T.; And Others

    1985-01-01

    Background information and procedures used are provided for the synthesis of 4,5-diphenyl-methylimidazole. This experiment on the chemistry of heterocycles is ideally suited for beginning undergraduate organic chemistry students. (JN)

  1. A Laboratory Course for Teaching Laboratory Techniques, Experimental Design, Statistical Analysis, and Peer Review Process to Undergraduate Science Students

    ERIC Educational Resources Information Center

    Gliddon, C. M.; Rosengren, R. J.

    2012-01-01

    This article describes a 13-week laboratory course called Human Toxicology taught at the University of Otago, New Zealand. This course used a guided inquiry based laboratory coupled with formative assessment and collaborative learning to develop in undergraduate students the skills of problem solving/critical thinking, data interpretation and…

  2. The Advanced Manufacturing Laboratory at RPI.

    ERIC Educational Resources Information Center

    Desrochers, A.; DeRusso, P. M.

    1984-01-01

    An Advanced Manufacturing Laboratory (AML) has been established at Rensselaer Polytechnic Institute (RPI). AML courses, course objectives, instructional strategies, student experiences in design and manufacturing, and AML equipment are discussed. Overall recommendations based on student and instructor experiences are also presented. (JN)

  3. Advanced Laboratory NMR Spectrometer with Applications.

    ERIC Educational Resources Information Center

    Biscegli, Clovis; And Others

    1982-01-01

    A description is given of an inexpensive nuclear magnetic resonance (NMR) spectrometer suitable for use in advanced laboratory courses. Applications to the nondestructive analysis of the oil content in corn seeds and in monitoring the crystallization of polymers are presented. (SK)

  4. Project Kaleidoscope: Advancing What Works in Undergraduate STEM Education

    NASA Astrophysics Data System (ADS)

    Elrod, S.

    2011-12-01

    In 1989, Project Kaleidoscope (PKAL) published its first report, What Works: Building Natural Science Communities, on reforming undergraduate STEM (science, technology, engineering and mathematics) education. Since then, PKAL has grown into a national organization comprised of a diverse group of over 6500 STEM educators who are committed to advancing "what works." The PKAL mission is to be a national leader in catalyzing the efforts of people, institutions, organizations and networks to move from analysis to action in significantly improving undergraduate student learning and achievement in STEM (science, technology, engineering and mathematics). Specifically, PKAL's strategic goals are to: 1) Promote the development and wider use of evidence-based teaching, learning and assessment approaches, 2) Build individual and organizational capacity to lead change in STEM education, and 3) Engage the broader community of external stakeholders - professional and disciplinary societies, business and industry groups, accreditation organizations, educational associations, governmental agencies, philanthropic organizations - in achieving our mission. PKAL achieves these goals by serving as the nexus of an interconnected and multidisciplinary web of people, ideas, strategies, evidence and resources focused on systemic change in undergraduate STEM education. PKAL also provides resources on critical issues, such as teaching using pedagogies of engagement, and engages interested faculty, campuses and professional societies in national projects and programs focused on cutting edge issues in STEM education. One of these projects - Mobilizing Disciplinary Societies for a Sustainable Future - is engaging eleven disciplinary societies, including the National Association of Geoscience Teachers, in defining specific resources, faculty development programs and goals focused on promoting undergraduate STEM courses that: 1) provide more knowledge about real-world issues; 2) connect these real

  5. Synthesis and Catalytic Activity of Ruthenium-Indenylidene Complexes for Olefin Metathesis: Microscale Experiments for the Undergraduate Inorganic or Organometallic Laboratories

    ERIC Educational Resources Information Center

    Pappenfus, Ted M.; Hermanson, David L.; Ekerholm, Daniel P.; Lilliquist, Stacie L.; Mekoli, Megan L.

    2007-01-01

    A series of experiments for undergraduate laboratory courses (e.g., inorganic, organometallic or advanced organic) have been developed. These experiments focus on understanding the design and catalytic activity of ruthenium-indenylidene complexes for olefin metathesis. Included in the experiments are the syntheses of two ruthenium-indenylidene…

  6. Determination of Sulfate by Conductometric Titration: An Undergraduate Laboratory Experiment

    ERIC Educational Resources Information Center

    Garcia, Jennifer; Schultz, Linda D.

    2016-01-01

    The classic technique for sulfate analysis in an undergraduate quantitative analysis lab involves precipitation as the barium salt with barium chloride, collection of the precipitate by gravity filtration using ashless filter paper, and removal of the filter paper by charring over a Bunsen burner. The entire process is time-consuming, hazardous,…

  7. Enhancing Undergraduate Agro-Ecological Laboratory Employment through Experiential Learning

    ERIC Educational Resources Information Center

    Grossman, J. M.; Patel, M.; Drinkwater, L. E.

    2010-01-01

    We piloted an educational model, the Sustainable Agriculture Scholars Program, linking research in organic agriculture to experiential learning activities for summer undergraduate employees in 2007 and 2008. Our objectives were to: (1) further student understanding of sustainable agriculture research, (2) increase student interest in sustainable…

  8. Coulometric Analysis Experiment for the Undergraduate Chemistry Laboratory

    ERIC Educational Resources Information Center

    Dabke, Rajeev B.; Gebeyehu, Zewdu; Thor, Ryan

    2011-01-01

    An undergraduate experiment on coulometric analysis of four commercial household products is presented. A special type of coulometry cell made of polydimethylsiloxane (PDMS) polymer is utilized. The PDMS cell consists of multiple analyte compartments and an internal network of salt bridges. Experimental procedure for the analysis of the acid in a…

  9. Undergraduate Laboratory Experiment Modules for Probing Gold Nanoparticle Interfacial Phenomena

    ERIC Educational Resources Information Center

    Karunanayake, Akila G.; Gunatilake, Sameera R.; Ameer, Fathima S.; Gadogbe, Manuel; Smith, Laura; Mlsna, Deb; Zhang, Dongmao

    2015-01-01

    Three gold-nanoparticle (AuNP) undergraduate experiment modules that are focused on nanoparticles interfacial phenomena have been developed. Modules 1 and 2 explore the synthesis and characterization of AuNPs of different sizes but with the same total gold mass. These experiments enable students to determine how particle size affects the AuNP…

  10. Integrated Laboratories: Laying the Foundation for Undergraduate Research Experiences

    ERIC Educational Resources Information Center

    Dillner, Debra K.; Ferrante, Robert F.; Fitzgerald, Jeffrey P.; Schroeder, Maria J.

    2011-01-01

    Interest in undergraduate student research has grown in response to initiatives from various professional societies and educational organizations. Participation in research changes student attitudes towards courses as they realize the utility and relevance of what they are learning. At the U.S. Naval Academy, the chemistry majors' curriculum was…

  11. Aza-Michael Reaction for an Undergraduate Organic Chemistry Laboratory

    ERIC Educational Resources Information Center

    Nigam, Manisha; Rush, Brittney; Patel, Jay; Castillo, Raul; Dhar, Preeti

    2016-01-01

    A green, aza-Michael reaction is described that can be used to teach undergraduate students conjugate addition of nitrogen nucleophile to an a,ß-unsaturated ester. Students analyze spectral data of the product obtained from the assigned reaction to determine product structure and propose the mechanism of its formation. The experiment requires…

  12. Upper-Level Undergraduate Chemistry Students' Goals for Their Laboratory Coursework

    ERIC Educational Resources Information Center

    DeKorver, Brittland K.; Towns, Marcy H.

    2016-01-01

    Efforts to reform undergraduate chemistry laboratory coursework typically focus on the curricula of introductory-level courses, while upper-level courses are bypassed. This study used video-stimulated recall to interview 17 junior- and senior- level chemistry majors after they carried out an experiment as part of a laboratory course. It is assumed…

  13. A Survey of the Practices, Procedures, and Techniques in Undergraduate Organic Chemistry Teaching Laboratories

    ERIC Educational Resources Information Center

    Martin, Christopher B.; Schmidt, Monica; Soniat, Michael

    2011-01-01

    A survey was conducted of four-year institutions that teach undergraduate organic chemistry laboratories in the United States. The data include results from over 130 schools, describes the current practices at these institutions, and discusses the statistical results such as the scale of the laboratories performed, the chemical techniques applied,…

  14. A Coastal Environment Field and Laboratory Activity for an Undergraduate Geomorphology Course

    ERIC Educational Resources Information Center

    Ellis, Jean T.; Rindfleisch, Paul R.

    2006-01-01

    A field and laboratory exercise for an undergraduate geomorphology class is described that focuses on the beach. The project requires one day of fieldwork and two laboratory sessions. In the field, students measure water surface fluctuations (waves) with a pressure sensor, survey beach profiles, collect sediment samples, and observe the beach…

  15. An Alternative Approach for Preparing and Standardizing Some Common Aqueous Reagents Used in an Undergraduate Laboratory

    ERIC Educational Resources Information Center

    Melaku, Samuel; Dabke, Rajeev B.

    2014-01-01

    A guide for instructors and laboratory assistants to prepare some common aqueous reagents used in an undergraduate laboratory is presented. Dilute reagents consisting of H[superscript +](aq), I[subscript 3][superscript-](aq), Ce[superscript 4+](aq), and Ag[superscript+](aq) were prepared by electrolytic oxidation of respective precursors.…

  16. A Microcomputer-Based Data Acquisition System for Use in Undergraduate Laboratories.

    ERIC Educational Resources Information Center

    Johnson, Ray L.

    1982-01-01

    A laboratory computer system based on the Commodore PET 2001 is described including three applications for the undergraduate analytical chemistry laboratory: (1) recording a UV-visible absorption spectrum; (2) recording and use of calibration curves; and (3) recording potentiometric data. Lists of data acquisition programs described are available…

  17. Can Report Templates Aid Student Learning in Undergraduate Chemistry Laboratory Classes?

    ERIC Educational Resources Information Center

    Paton-Walsh, Clare

    2015-01-01

    This paper describes a study aimed at assessing the ability of report templates to help students learn key concepts during undergraduate laboratory classes. The report templates were designed so that a set of assessment questions led the students through the logical steps required to perform the laboratory exercise and to calculate the required…

  18. Green Chemistry Decision-Making in an Upper-Level Undergraduate Organic Laboratory

    ERIC Educational Resources Information Center

    Edgar, Landon J. G.; Koroluk, Katherine J.; Golmakani, Mehrnaz; Dicks, Andrew P.

    2014-01-01

    A self-directed independent synthesis experiment was developed for a third-year undergraduate organic laboratory. Students were provided with the CAS numbers of starting and target compounds and devised a synthetic plan to be executed over two 4.5 h laboratory periods. They consulted the primary literature in order to develop and carry out an…

  19. Investigating Affective Experiences in the Undergraduate Chemistry Laboratory: Students' Perceptions of Control and Responsibility

    ERIC Educational Resources Information Center

    Galloway, Kelli R.; Malakpa, Zoebedeh; Bretz, Stacey Lowery

    2016-01-01

    Meaningful learning requires the integration of cognitive and affective learning with the psychomotor, i.e., hands-on learning. The undergraduate chemistry laboratory is an ideal place for meaningful learning to occur. However, accurately characterizing students' affective experiences in the chemistry laboratory can be a very difficult task. While…

  20. Hairy Root as a Model System for Undergraduate Laboratory Curriculum and Research

    ERIC Educational Resources Information Center

    Keyes, Carol A.; Subramanian, Senthil; Yu, Oliver

    2009-01-01

    Hairy root transformation has been widely adapted in plant laboratories to rapidly generate transgenic roots for biochemical and molecular analysis. We present hairy root transformations as a versatile and adaptable model system for a wide variety of undergraduate laboratory courses and research. This technique is easy, efficient, and fast making…

  1. An Operationally Simple Sonogashira Reaction for an Undergraduate Organic Chemistry Laboratory Class

    ERIC Educational Resources Information Center

    Cranwell, Philippa B.; Peterson, Alexander M.; Littlefield, Benjamin T. R.; Russell, Andrew T.

    2015-01-01

    An operationally simple, reliable, and cheap Sonogashira reaction suitable for an undergraduate laboratory class that can be completed within a day-long (8 h) laboratory session has been developed. Cross-coupling is carried out between 2-methyl-3-butyn-2-ol and various aryl iodides using catalytic amounts of bis(triphenylphosphine)palladium(II)…

  2. The Design, Enactment, and Impact of an Undergraduate, Inquiry-Based, Astronomy Laboratory Learning Environment

    ERIC Educational Resources Information Center

    Stewart, Steven A.

    2013-01-01

    This study investigated the design, enactment, and impact of an undergraduate, inquiry-based astronomy laboratory learning environment. The professor, Richard, adopted laboratory materials from the Center for Astronomy and Physics Education Research [CAPER] which were described by the group as inquiry-based. Students worked through these…

  3. Development, Implementation, and Analysis of a National Survey of Faculty Goals for Undergraduate Chemistry Laboratory

    ERIC Educational Resources Information Center

    Bruck, Aaron D.; Towns, Marcy

    2013-01-01

    This work reports the development of a survey for laboratory goals in undergraduate chemistry, the analysis of reliable and valid data collected from a national survey of college chemistry faculty, and a synthesis of the findings. The study used a sequential exploratory mixed-methods design. Faculty goals for laboratory emerged across seven…

  4. An Undergraduate Laboratory Experiment in Bioinorganic Chemistry: Ligation States of Myoglobin

    ERIC Educational Resources Information Center

    Bailey, James A.

    2011-01-01

    Although there are numerous inorganic model systems that are readily presented as undergraduate laboratory experiments in bioinorganic chemistry, there are few examples that explore the inorganic chemistry of actual biological molecules. We present a laboratory experiment using the oxygen-binding protein myoglobin that can be easily incorporated…

  5. Conceptual Change in the Undergraduate Biology Teaching Laboratory: A "Type Specimen" Case Study.

    ERIC Educational Resources Information Center

    Jones, Dorothy A.; Eichinger, David C.

    This paper introduces the biology laboratory as a learning project. Biology laboratories provide unique learning opportunities to students as traditional achievement outcome measures, and play an important role in the development of process skills, manual skills, and attitudes. However, there is insufficient data on undergraduate students majoring…

  6. Biotechnology by Design: An Introductory Level, Project-Based, Synthetic Biology Laboratory Program for Undergraduate Students†

    PubMed Central

    Beach, Dale L.; Alvarez, Consuelo J.

    2015-01-01

    Synthetic biology offers an ideal opportunity to promote undergraduate laboratory courses with research-style projects, immersing students in an inquiry-based program that enhances the experience of the scientific process. We designed a semester-long, project-based laboratory curriculum using synthetic biology principles to develop a novel sensory device. Students develop subject matter knowledge of molecular genetics and practical skills relevant to molecular biology, recombinant DNA techniques, and information literacy. During the spring semesters of 2014 and 2015, the Synthetic Biology Laboratory Project was delivered to sophomore genetics courses. Using a cloning strategy based on standardized BioBrick genetic “parts,” students construct a “reporter plasmid” expressing a reporter gene (GFP) controlled by a hybrid promoter regulated by the lac-repressor protein (lacI). In combination with a “sensor plasmid,” the production of the reporter phenotype is inhibited in the presence of a target environmental agent, arabinose. When arabinose is absent, constitutive GFP expression makes cells glow green. But the presence of arabinose activates a second promoter (pBAD) to produce a lac-repressor protein that will inhibit GFP production. Student learning was assessed relative to five learning objectives, using a student survey administered at the beginning (pre-survey) and end (post-survey) of the course, and an additional 15 open-ended questions from five graded Progress Report assignments collected throughout the course. Students demonstrated significant learning gains (p < 0.05) for all learning outcomes. Ninety percent of students indicated that the Synthetic Biology Laboratory Project enhanced their understanding of molecular genetics. The laboratory project is highly adaptable for both introductory and advanced courses. PMID:26753032

  7. Biotechnology by Design: An Introductory Level, Project-Based, Synthetic Biology Laboratory Program for Undergraduate Students.

    PubMed

    Beach, Dale L; Alvarez, Consuelo J

    2015-12-01

    Synthetic biology offers an ideal opportunity to promote undergraduate laboratory courses with research-style projects, immersing students in an inquiry-based program that enhances the experience of the scientific process. We designed a semester-long, project-based laboratory curriculum using synthetic biology principles to develop a novel sensory device. Students develop subject matter knowledge of molecular genetics and practical skills relevant to molecular biology, recombinant DNA techniques, and information literacy. During the spring semesters of 2014 and 2015, the Synthetic Biology Laboratory Project was delivered to sophomore genetics courses. Using a cloning strategy based on standardized BioBrick genetic "parts," students construct a "reporter plasmid" expressing a reporter gene (GFP) controlled by a hybrid promoter regulated by the lac-repressor protein (lacI). In combination with a "sensor plasmid," the production of the reporter phenotype is inhibited in the presence of a target environmental agent, arabinose. When arabinose is absent, constitutive GFP expression makes cells glow green. But the presence of arabinose activates a second promoter (pBAD) to produce a lac-repressor protein that will inhibit GFP production. Student learning was assessed relative to five learning objectives, using a student survey administered at the beginning (pre-survey) and end (post-survey) of the course, and an additional 15 open-ended questions from five graded Progress Report assignments collected throughout the course. Students demonstrated significant learning gains (p < 0.05) for all learning outcomes. Ninety percent of students indicated that the Synthetic Biology Laboratory Project enhanced their understanding of molecular genetics. The laboratory project is highly adaptable for both introductory and advanced courses.

  8. ATR-FTIR Spectroscopy in the Undergraduate Chemistry Laboratory: Part II--A Physical Chemistry Laboratory Experiment on Surface Adsorption

    ERIC Educational Resources Information Center

    Schuttlefield, Jennifer D.; Larsen, Sarah C.; Grassian, Vicki H.

    2008-01-01

    Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy is a useful technique for measuring the infrared spectra of solids and liquids as well as probing adsorption on particle surfaces. The use of FTIR-ATR spectroscopy in organic and inorganic chemistry laboratory courses as well as in undergraduate research was presented…

  9. Advanced Simulation in Undergraduate Pilot Training: Systems Integration. Final Report (February 1972-March 1975).

    ERIC Educational Resources Information Center

    Larson, D. F.; Terry, C.

    The Advanced Simulator for Undergraduate Pilot Training (ASUPT) was designed to investigate the role of simulation in the future Undergraduate Pilot Training (UPT) program. The problem addressed in this report was one of integrating two unlike components into one synchronized system. These two components were the Basic T-37 Simulators and their…

  10. Motion tracking in undergraduate physics laboratories with the Wii remote

    NASA Astrophysics Data System (ADS)

    Tomarken, Spencer L.; Simons, Dallas R.; Helms, Richard W.; Johns, Will E.; Schriver, Kenneth E.; Webster, Medford S.

    2012-04-01

    We report the incorporation of the Wiimote, a light-tracking remote control device, into two undergraduate-level experiments. We provide an overview of the Wiimote's basic functions and a systematic analysis of its motion tracking capabilities. We describe the Wiimote's use in measuring conservation of linear and angular momentum on an air table, and measuring the gravitational constant with the classic Cavendish torsion pendulum. Our results show that Wiimote is a simple and affordable way to streamline the data acquisition process and produce results that are generally superior to those obtained with conventional techniques.

  11. A New Model for Transitioning Students from the Undergraduate Teaching Laboratory to the Research Laboratory

    ERIC Educational Resources Information Center

    Hollenbeck, Jessica J.; Wixson, Emily N.; Geske, Grant D.; Dodge, Matthew W.; Tseng, T. Andrew; Clauss, Allen D.; Blackwell, Helen E.

    2006-01-01

    The transformation of 346 chemistry courses into a training experience that could provide undergraduate students with a skill set essential for a research-based chemistry career is presented. The course has an innovative structure that connects undergraduate students with graduate research labs at the semester midpoint and also includes new,…

  12. Practicing biology: Undergraduate laboratory research, persistence in science, and the impact of self-efficacy beliefs

    NASA Astrophysics Data System (ADS)

    Berkes, Elizabeth

    As undergraduate laboratory research internships become more popular and universities devote considerable resources towards promoting them, it is important to clarify what students specifically gain through involvement in these experiences and it is important to understand their impact on the science pipeline. By examining recent findings describing the primary benefits of undergraduate research participation, along with self-efficacy theory, this study aims to provide more explanatory power to the anecdotal and descriptive accounts regarding the relationship between undergraduate research experiences and interest in continuing in science. Furthermore, this study characterizes practices that foster students' confidence in doing scientific work with detailed description and analysis of the interactions of researchers in a laboratory. Phase 1 of the study, a survey of undergraduate biology majors (n=71) at a major research university, investigates the relationships among participation in biology laboratory research internships, biology laboratory self-efficacy strength, and interest in persisting in science. Phase 2 of the study, a two-year investigation of a university biology research laboratory, investigates how scientific communities of practice develop self-efficacy beliefs. The findings suggest that participation in lab internships results in increased interest in continuing in life science/biology graduate school and careers. They also suggest that a significant proportion of that interest is related to the students' biology laboratory self-efficacy. The findings of this study point to two primary ways that undergraduate research participation might work to raise self-efficacy strength. First, university research laboratory communities can provide students with a variety of resources that scaffold them into biology laboratory mastery experiences. Second, university research laboratory communities can provide students with coping and mastery Discourse models

  13. Creative Report Writing in Undergraduate Organic Chemistry Laboratory Inspires Nonmajors

    ERIC Educational Resources Information Center

    Henary, Maged; Owens, Eric A.; Tawney, Joseph G.

    2015-01-01

    Laboratory-based courses require students to compose reports based on the performed experiments to assess their overall understanding of the presented material; unfortunately, the sterile and formulated nature of the laboratory report disinterests most students. As a result, the outcome is a lower-quality product that does not reveal full…

  14. Assessing Practical Laboratory Skills in Undergraduate Molecular Biology Courses

    ERIC Educational Resources Information Center

    Hunt, Lynne; Koenders, Annette; Gynnild, Vidar

    2012-01-01

    This study explored a new strategy of assessing laboratory skills in a molecular biology course to improve: student effort in preparation for and participation in laboratory work; valid evaluation of learning outcomes; and students' employment prospects through provision of evidence of their skills. Previously, assessment was based on written…

  15. Merging of Research and Teaching in Developmental Biology: Adaptation of Current Scientific Research Papers for Use in Undergraduate Laboratory Exercises

    ERIC Educational Resources Information Center

    Lee, H. H.; and others

    1970-01-01

    Describes two laboratory exercises adopted from current research papers for use in an undergraduate developmental biology course. Gives methods, summary of student results, and student comments. Lists lecture topics, text and reprint assignments, and laboratory exercises for course. (EB)

  16. Topics in Chemical Instrumentation: Information Management Systems in the Undergraduate Instrumental Analysis Laboratory: Part I. Introduction to LIMS.

    ERIC Educational Resources Information Center

    Merrer, Robert J.

    1985-01-01

    Provides an overview of Laboratory Information Management Systems (LIMS) and their implementation in undergraduate analytical laboratories. Basic components of a well-constructed LIMS system, hardware considerations, and software considerations are addressed. (JN)

  17. Validating the Collision-Dominated Child-Langmuir Law for a DC Discharge Cathode Sheath in an Undergraduate Laboratory

    ERIC Educational Resources Information Center

    Lisovskiy, V.; Yegorenkov, V.

    2009-01-01

    In this paper, we propose a simple method of observing the collision-dominated Child-Langmuir law in the course of an undergraduate laboratory work devoted to studying the properties of gas discharges. To this end we employ the dc gas discharge whose properties are studied in sufficient detail. The undergraduate laboratory work itself is reduced…

  18. High Performance Liquid Chromatography Experiments to Undergraduate Laboratories

    ERIC Educational Resources Information Center

    Kissinger, Peter T.; And Others

    1977-01-01

    Reviews the principles of liquid chromatography with electrochemical detection (LCEC), an analytical technique that incorporates the advantages of both liquids chromatography and electrochemistry. Also suggests laboratory experiments using this technique. (MLH)

  19. Cross-Disciplinary Thermoregulation and Sweat Analysis Laboratory Experiences for Undergraduate Chemistry and Exercise Science Students

    ERIC Educational Resources Information Center

    Mulligan, Gregory; Taylor, Nichole; Glen, Mary; Tomlin, Dona; Gaul, Catherine A.

    2011-01-01

    Cross-disciplinary (CD) learning experiences benefit student understanding of concepts and curriculum by offering opportunities to explore topics from the perspectives of alternate fields of study. This report involves a qualitative evaluation of CD health sciences undergraduate laboratory experiences in which concepts and students from two…

  20. High-Performance Liquid Chromatography in the Undergraduate Chemical Engineering Laboratory

    ERIC Educational Resources Information Center

    Frey, Douglas D.; Guo, Hui; Karnik, Nikhila

    2013-01-01

    This article describes the assembly of a simple, low-cost, high-performance liquid chromatography (HPLC) system and its use in the undergraduate chemical engineering laboratory course to perform simple experiments. By interpreting the results from these experiments students are able to gain significant experience in the general method of…

  1. ATR-FTIR Spectroscopy in the Undergraduate Chemistry Laboratory: Part I--Fundamentals and Examples

    ERIC Educational Resources Information Center

    Schuttlefield, Jennifer D.; Grassian, Vicki H.

    2008-01-01

    Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy is a useful technique for measuring the infrared spectra of solids and liquids as well as probing adsorption on particle surfaces. Several examples of the use of FTIR-ATR spectroscopy in different undergraduate chemistry laboratory courses are presented here. These…

  2. Incorporating Course-Based Undergraduate Research Experiences into Analytical Chemistry Laboratory Curricula

    ERIC Educational Resources Information Center

    Kerr, Melissa A.; Yan, Fei

    2016-01-01

    A continuous effort within an undergraduate university setting is to improve students' learning outcomes and thus improve students' attitudes about a particular field of study. This is undoubtedly relevant within a chemistry laboratory. This paper reports the results of an effort to introduce a problem-based learning strategy into the analytical…

  3. A Static Method as an Alternative to Gel Chromatography: An Experiment for the Undergraduate Biochemistry Laboratory

    ERIC Educational Resources Information Center

    Burum, Alex D.; Splittgerber, Allan G.

    2008-01-01

    This article describes a static method as an alternative to gel chromatography, which may be used as an undergraduate laboratory experiment. In this method, a constant mass of Sephadex gel is swollen in a series of protein solutions. UV-vis spectrophotometry is used to find a partition coefficient, KD, that indicates the fraction of the interior…

  4. Investigation of the Regioselectivity of Alkene Hydrations for the Undergraduate Organic Laboratory

    ERIC Educational Resources Information Center

    Bichler, Katherine A.; Van Ornum, Scott G.; Franz, Margaret C.; Imhoff, Andrea M.

    2015-01-01

    Due to a lack of time and, thus, an inability to present every possibility in a chemical reaction, organic chemistry professors tend to present each reaction with a single outcome. In practice, this is clearly not the case. A first-semester, three-week laboratory experiment designed for undergraduate organic chemistry students is described in…

  5. Determination of Equilibrium Constants of Metal Complexes from Spectrophotometric Measurements. An Undergraduate Laboratory Experiment

    NASA Astrophysics Data System (ADS)

    Ibañez, Gabriela A.; Olivieri, Alejandro C.; Escandar*, Graciela M.

    1999-09-01

    We describe an undergraduate laboratory practice involving the determination of complex equilibrium constants by spectrophotometric techniques. The results are obtained through model fitting using a computer program. As an example of these determinations, salicylic acid was selected and evaluated in the presence of copper(II) ion. The experimental conditions, general procedures, and computational strategem are discussed.

  6. The Quartz-Crystal Microbalance in an Undergraduate Laboratory Experiment: Measuring Mass

    ERIC Educational Resources Information Center

    Tsionsky, Vladimir

    2007-01-01

    The study explains the quartz-crystal microbalance (QCM) technique, which is often used as an undergraduate laboratory experiment for measuring the mass of a system. QCM can be used as a mass sensor only when the measured mass is rigidly attached to the surface.

  7. Making Microscopy Motivating, Memorable, & Manageable for Undergraduate Students with Digital Imaging Laboratories

    ERIC Educational Resources Information Center

    Weeks, Andrea; Bachman. Beverly; Josway, Sarah; North, Brittany; Tsuchiya, Mirian T.N.

    2013-01-01

    Microscopy and precise observation are essential skills that are challenging to teach effectively to large numbers of undergraduate biology students. We implemented student-driven digital imaging assignments for microscopy in a large enrollment laboratory for organismal biology. We detail how we promoted student engagement with the material and…

  8. Undergraduate Introductory Quantitative Chemistry Laboratory Course: Interdisciplinary Group Projects in Phytoremediation

    ERIC Educational Resources Information Center

    Van Engelen, Debra L.; Suljak, Steven W.; Hall, J. Patrick; Holmes, Bert E.

    2007-01-01

    The laboratory course around the phytoremediation is designed to develop both individual skills and promote cooperative learning while starting students work on projects in a specific area of environmental chemistry and analysis. Many research-active undergraduate institutions have developed courses, which are interdisciplinary in nature that…

  9. Development of an Assessment Tool to Measure Students' Meaningful Learning in the Undergraduate Chemistry Laboratory

    ERIC Educational Resources Information Center

    Galloway, Kelli R.; Bretz, Stacey Lowery

    2015-01-01

    Research on learning in the undergraduate chemistry laboratory necessitates an understanding of students' perspectives of learning. Novak's Theory of Meaningful Learning states that the cognitive (thinking), affective (feeling), and psychomotor (doing) domains must be integrated for meaningful learning to occur. The psychomotor domain is the…

  10. Thermodynamics of Sodium Dodecyl Sulfate (SDS) Micellization: An Undergraduate Laboratory Experiment

    ERIC Educational Resources Information Center

    Marcolongo, Juan P.; Mirenda, Martin

    2011-01-01

    An undergraduate laboratory experiment is presented that allows a thermodynamic characterization of micelle formation of sodium dodecyl sulfate (SDS) in aqueous solutions. The critical micelle concentration (CMC) and the degree of micelle ionization (alpha) are obtained at different temperatures by conductimetry. The molar standard free energy…

  11. Borohydride Reduction of Estrone: Demonstration of Diastereoselectivity in the Undergraduate Organic Chemistry Laboratory

    ERIC Educational Resources Information Center

    Aditya, Animesh; Nichols, David E.; Loudon, G. Marc

    2008-01-01

    This experiment presents a guided-inquiry approach to the demonstration of diastereoselectivity in an undergraduate organic chemistry laboratory. Chiral hindered ketones such as estrone, undergo facile reduction with sodium borohydride in a highly diastereoselective manner. The diastereomeric estradiols produced in the reaction can be analyzed and…

  12. A Green Polymerization of Aspartic Acid for the Undergraduate Organic Laboratory

    ERIC Educational Resources Information Center

    Bennett, George D.

    2005-01-01

    The green polymerization of aspartic acid carried out during an organic-inorganic synthesis laboratory course for undergraduate students is described. The procedure is based on work by Donlar Corporation, a Peru, Illinois-based company that won a Green Chemistry Challenge Award in 1996 in the Small Business category for preparing thermal…

  13. An Integrated Visualization and Basic Molecular Modeling Laboratory for First-Year Undergraduate Medicinal Chemistry

    ERIC Educational Resources Information Center

    Hayes, Joseph M.

    2014-01-01

    A 3D model visualization and basic molecular modeling laboratory suitable for first-year undergraduates studying introductory medicinal chemistry is presented. The 2 h practical is embedded within a series of lectures on drug design, target-drug interactions, enzymes, receptors, nucleic acids, and basic pharmacokinetics. Serving as a teaching aid…

  14. An Undergraduate Course and Laboratory in Digital Signal Processing with Field Programmable Gate Arrays

    ERIC Educational Resources Information Center

    Meyer-Base, U.; Vera, A.; Meyer-Base, A.; Pattichis, M. S.; Perry, R. J.

    2010-01-01

    In this paper, an innovative educational approach to introducing undergraduates to both digital signal processing (DSP) and field programmable gate array (FPGA)-based design in a one-semester course and laboratory is described. While both DSP and FPGA-based courses are currently present in different curricula, this integrated approach reduces the…

  15. Impact of Collaborative Groups versus Individuals in Undergraduate Inquiry-Based Astronomy Laboratory Learning Exercises

    ERIC Educational Resources Information Center

    Sibbernsen, Kendra J.

    2014-01-01

    A mixed-method quasi-experimental study was designed to determine how 130 undergraduates in an introductory astronomy survey course laboratory changed their understanding of scientific inquiry working as individuals in relative isolation compared to working in small, collaborative learning groups when using specially designed astronomy curricula…

  16. Development of a Web-Enabled Learning Platform for Geospatial Laboratories: Improving the Undergraduate Learning Experience

    ERIC Educational Resources Information Center

    Mui, Amy B.; Nelson, Sarah; Huang, Bruce; He, Yuhong; Wilson, Kathi

    2015-01-01

    This paper describes a web-enabled learning platform providing remote access to geospatial software that extends the learning experience outside of the laboratory setting. The platform was piloted in two undergraduate courses, and includes a software server, a data server, and remote student users. The platform was designed to improve the quality…

  17. Testing Plastic Deformations of Materials in the Introductory Undergraduate Mechanics Laboratory

    ERIC Educational Resources Information Center

    Romo-Kroger, C. M.

    2012-01-01

    Normally, a mechanics laboratory at the undergraduate level includes an experiment to verify compliance with Hooke's law in materials, such as a steel spring and an elastic rubber band. Stress-strain curves are found for these elements. Compression in elastic bands is practically impossible to achieve due to flaccidity. A typical experiment for…

  18. A Measure of the Effectiveness of Incorporating 3D Human Anatomy into an Online Undergraduate Laboratory

    ERIC Educational Resources Information Center

    Hilbelink, Amy J.

    2009-01-01

    Results of a study designed to determine the effectiveness of implementing three-dimensional (3D) stereo images of a human skull in an undergraduate human anatomy online laboratory were gathered and analysed. Mental model theory and its applications to 3D relationships are discussed along with the research results. Quantitative results on 62 pairs…

  19. Glucose Transport in Cultured Animal Cells: An Exercise for the Undergraduate Cell Biology Laboratory

    ERIC Educational Resources Information Center

    Ledbetter, Mary Lee S.; Lippert, Malcolm J.

    2002-01-01

    Membrane transport is a fundamental concept that undergraduate students of cell biology understand better with laboratory experience. Formal teaching exercises commonly used to illustrate this concept are unbiological, qualitative, or intricate and time consuming to prepare. We have developed an exercise that uses uptake of radiolabeled nutrient…

  20. Analyzing Exonuclease-Induced Hyperchromicity by Uv Spectroscopy: An Undergraduate Biochemistry Laboratory Experiment

    ERIC Educational Resources Information Center

    Ackerman, Megan M.; Ricciardi, Christopher; Weiss, David; Chant, Alan; Kraemer-Chant, Christina M.

    2016-01-01

    An undergraduate biochemistry laboratory experiment is described that utilizes free online bioinformatics tools along with readily available exonucleases to study the effects of base stacking and hydrogen bonding on the UV absorbance of DNA samples. UV absorbance of double-stranded DNA at the ?[subscript max] is decreased when the DNA bases are…

  1. Construction of an Instructional Design Model for Undergraduate Chemistry Laboratory Design: A Delphi Approach

    ERIC Educational Resources Information Center

    Bunag, Tara

    2012-01-01

    The purpose of this study was to construct an instructional systems design model for chemistry teaching laboratories at the undergraduate level to accurately depict the current practices of design experts. This required identifying the variables considered during design, prioritizing and ordering these variables, and constructing a model. Experts…

  2. Purification and Characterization of Enzymes from Yeast: An Extended Undergraduate Laboratory Sequence for Large Classes

    ERIC Educational Resources Information Center

    Johanson, Kelly E.; Watt, Terry J.; McIntyre, Neil R.; Thompson, Marleesa

    2013-01-01

    Providing a project-based experience in an undergraduate biochemistry laboratory class can be complex with large class sizes and limited resources. We have designed a 6-week curriculum during which students purify and characterize the enzymes invertase and phosphatase from bakers yeast. Purification is performed in two stages via ethanol…

  3. Incorporation of Gas Chromatography-Mass Spectrometry into the Undergraduate Organic Chemistry Laboratory Curriculum

    ERIC Educational Resources Information Center

    Giarikos, Dimitrios G.; Patel, Sagir; Lister, Andrew; Razeghifard, Reza

    2013-01-01

    Gas chromatography-mass spectrometry (GC-MS) is a powerful analytical tool for detection, identification, and quantification of many volatile organic compounds. However, many colleges and universities have not fully incorporated this technique into undergraduate teaching laboratories despite its wide application and ease of use in organic…

  4. Investigation of Macrophage Differentiation and Cytokine Production in an Undergraduate Immunology Laboratory

    ERIC Educational Resources Information Center

    Berkes, Charlotte; Chan, Leo Li-Ying

    2015-01-01

    We have developed a semester-long laboratory project for an undergraduate immunology course in which students study multiple aspects of macrophage biology including differentiation from progenitors in the bone marrow, activation upon stimulation with microbial ligands, expression of cell surface markers, and modulation of cytokine production. In…

  5. Student Perceptions of the Cell Biology Laboratory Learning Environment in Four Undergraduate Science Courses in Spain

    ERIC Educational Resources Information Center

    De Juan, Joaquin; Pérez-Cañaveras, Rosa M.; Segovia, Yolanda; Girela, Jose Luis; Martínez-Ruiz, Noemi; Romero-Rameta, Alejandro; Gómez-Torres, Maria José; Vizcaya-Moreno, M. Flores

    2016-01-01

    Cell biology is an academic discipline that organises and coordinates the learning of the structure, function and molecular composition of cells in some undergraduate biomedical programs. Besides course content and teaching methodologies, the laboratory environment is considered a key element in the teaching of and learning of cell biology. The…

  6. Gas Clathrate Hydrates Experiment for High School Projects and Undergraduate Laboratories

    ERIC Educational Resources Information Center

    Prado, Melissa P.; Pham, Annie; Ferazzi, Robert E.; Edwards, Kimberly; Janda, Kenneth C.

    2007-01-01

    We present a laboratory procedure, suitable for high school and undergraduate students, for preparing and studying propane clathrate hydrate. Because of their gas storage potential and large natural deposits, gas clathrate hydrates may have economic importance both as an energy source and a transportation medium. Similar to pure ice, the gas…

  7. Microfluidics in the Undergraduate Laboratory: Device Fabrication and an Experiment to Mimic Intravascular Gas Embolism

    ERIC Educational Resources Information Center

    Jablonski, Erin L.; Vogel, Brandon M.; Cavanagh, Daniel P.; Beers, Kathryn L.

    2010-01-01

    A method to fabricate microfluidic devices and an experimental protocol to model intravascular gas embolism for undergraduate laboratories are presented. The fabrication process details how to produce masters on glass slides; these masters serve as molds to pattern channels in an elastomeric polymer that can be adhered to a substrate, resulting in…

  8. Bacterial Production of Poly(3-hydroxybutyrate): An Undergraduate Student Laboratory Experiment

    ERIC Educational Resources Information Center

    Burns, Kristi L.; Oldham, Charlie D.; May, Sheldon W.

    2009-01-01

    As part of a multidisciplinary course that is cross-listed between five departments, we developed an undergraduate student laboratory experiment for culturing, isolating, and purifying the biopolymer, poly(3-hydroxybutyrate), PHB. This biopolyester accumulates in the cytoplasm of bacterial cells under specific growth conditions, and it has…

  9. The Impact of Collaborative Groups versus Individuals in Undergraduate Inquiry-Based Astronomy Laboratory Learning Exercises

    ERIC Educational Resources Information Center

    Sibbernsen, Kendra J.

    2010-01-01

    One of the long-standing general undergraduate education requirements common to many colleges and universities is a science course with a laboratory experience component. One of the objectives frequently included in the description of most of these courses is that a student will understand the nature and processes of scientific inquiry. However,…

  10. Topics in Chemical Instrumentation: XCVIII. Experiments Involving Thermal Methods of Analysis for Undergraduate Chemistry Laboratories.

    ERIC Educational Resources Information Center

    Ewing, Galen W., Ed.

    1978-01-01

    Explains some experiments involving thermal methods of analysis for undergraduate chemistry laboratories. Some experiments are: (1) the determination of the density and degree of crystallinity of a polymer; and (2) the determination of the specific heat of a nonvolatile compound. (HM)

  11. Transitioning from Expository Laboratory Experiments to Course-Based Undergraduate Research in General Chemistry

    ERIC Educational Resources Information Center

    Clark, Ted M.; Ricciardo, Rebecca; Weaver, Tyler

    2016-01-01

    General chemistry courses predominantly use expository experiments that shape student expectations of what a laboratory activity entails. Shifting within a semester to course-based undergraduate research activities that include greater decision-making, collaborative work, and "messy" real-world data necessitates a change in student…

  12. Microfluidic Gel Electrophoresis in the Undergraduate Laboratory Applied to Food Analysis

    ERIC Educational Resources Information Center

    Chao, Tzu-Chiao; Bhattacharya, Sanchari; Ros, Alexandra

    2012-01-01

    A microfluidics-based laboratory experiment for the analysis of DNA fragments in an analytical undergraduate course is presented. The experiment is set within the context of food species identification via amplified DNA fragments. The students are provided with berry samples from which they extract DNA and perform polymerase chain reaction (PCR)…

  13. Integrating Bio-Inorganic and Analytical Chemistry into an Undergraduate Biochemistry Laboratory

    ERIC Educational Resources Information Center

    Erasmus, Daniel J.; Brewer, Sharon E.; Cinel, Bruno

    2015-01-01

    Undergraduate laboratories expose students to a wide variety of topics and techniques in a limited amount of time. This can be a challenge and lead to less exposure to concepts and activities in bio-inorganic chemistry and analytical chemistry that are closely-related to biochemistry. To address this, we incorporated a new iron determination by…

  14. Computation of Chemical Shifts for Paramagnetic Molecules: A Laboratory Experiment for the Undergraduate Curriculum

    ERIC Educational Resources Information Center

    Pritchard, Benjamin P.; Simpson, Scott; Zurek, Eva; Autschbach, Jochen

    2014-01-01

    A computational experiment investigating the [superscript 1]H and [superscript 13]C nuclear magnetic resonance (NMR) chemical shifts of molecules with unpaired electrons has been developed and implemented. This experiment is appropriate for an upper-level undergraduate laboratory course in computational, physical, or inorganic chemistry. The…

  15. 3D Printing of Protein Models in an Undergraduate Laboratory: Leucine Zippers

    ERIC Educational Resources Information Center

    Meyer, Scott C.

    2015-01-01

    An upper-division undergraduate laboratory experiment is described that explores the structure/function relationship of protein domains, namely leucine zippers, through a molecular graphics computer program and physical models fabricated by 3D printing. By generating solvent accessible surfaces and color-coding hydrophobic, basic, and acidic amino…

  16. Excited-State Processes in Slow Motion: An Experiment in the Undergraduate Laboratory

    ERIC Educational Resources Information Center

    Galley, William C.; Tanchak, Oleh M.; Yager, Kevin G.; Wilczek-Vera, Grazyna

    2010-01-01

    Lasers have transformed chemistry and the everyday world. Therefore, it is not surprising that undergraduate chemistry students are frequently exposed to fairly advanced laser techniques. The usual topics studied with lasers are molecular spectroscopy and chemical kinetics. Static and dynamic fluorescence experiments seem to be particularly…

  17. Solvent Extraction of Copper: An Extractive Metallurgy Exercise for Undergraduate Teaching Laboratories

    ERIC Educational Resources Information Center

    Smellie, Iain A.; Forgan, Ross S.; Brodie, Claire; Gavine, Jack S.; Harris, Leanne; Houston, Daniel; Hoyland, Andrew D.; McCaughan, Rory P.; Miller, Andrew J.; Wilson, Liam; Woodhall, Fiona M.

    2016-01-01

    A multidisciplinary experiment for advanced undergraduate students has been developed in the context of extractive metallurgy. The experiment serves as a model of an important modern industrial process that combines aspects of organic/inorganic synthesis and analysis. Students are tasked to prepare a salicylaldoxime ligand and samples of the…

  18. Integration of Computational Chemistry into the Undergraduate Organic Chemistry Laboratory Curriculum

    ERIC Educational Resources Information Center

    Esselman, Brian J.; Hill, Nicholas J.

    2016-01-01

    Advances in software and hardware have promoted the use of computational chemistry in all branches of chemical research to probe important chemical concepts and to support experimentation. Consequently, it has become imperative that students in the modern undergraduate curriculum become adept at performing simple calculations using computational…

  19. Advanced Materials Laboratory User Test Planning Guide

    NASA Technical Reports Server (NTRS)

    Orndoff, Evelyne

    2012-01-01

    Test process, milestones and inputs are unknowns to first-time users of the Advanced Materials Laboratory. The User Test Planning Guide aids in establishing expectations for both NASA and non-NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their test engineering personnel in test planning and execution. Material covered includes a roadmap of the test process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, test article interfaces, and inputs necessary to define test scope, cost, and schedule are included as an appendix to the guide.

  20. DNA Topology Analysis in the Undergraduate Biochemistry Laboratory

    NASA Astrophysics Data System (ADS)

    Keck, Michael V.

    2000-11-01

    The ability of a cell to control precisely and regulate DNA winding and topology is critical for many intracellular processes, such as replication, transcription, recombination, and repair. A set of complementary experiments is described which are useful in teaching the principles of DNA topology to undergraduate biochemistry students. In one experiment, a copper-o-phenanthroline complex is used to oxidatively cleave closed circular supercoiled DNA and generate nicked and linear forms. In the second experiment, the antitumor agent cis-diamminedichloroplatinum is used to gradually remove supercoils by unwinding the DNA helix. In a third experiment, DNA topoisomerase I is used to generate a set of topoisomers of covalently closed circular DNA. In all experiments, the results are readily analyzed by agarose gel electrophoresis. Together, these experiments greatly facilitate the students' understanding of the basic principles of DNA topology and provide an interesting backdrop for teaching agarose gel electrophoresis methodology. They also serve to introduce topics such as small molecule-DNA interactions and DNA damage and repair.

  1. Complementary Spectroscopic Assays for Investigating Protein-Ligand Binding Activity: A Project for the Advanced Chemistry Laboratory

    ERIC Educational Resources Information Center

    Mascotti, David P.; Waner, Mark J.

    2010-01-01

    A protein-ligand binding, guided-inquiry laboratory project with potential application across the advanced undergraduate curriculum is described. At the heart of the project are fluorescence and spectrophotometric assays utilizing biotin-4-fluorescein and streptavidin. The use of the same stock solutions for an assay that may be examined by two…

  2. Adsorption of Phosphate on Goethite: An Undergraduate Research Laboratory Project

    ERIC Educational Resources Information Center

    Tribe, Lorena; Barja, Beatriz C.

    2004-01-01

    A laboratory experiment on the adsorption of phosphate on goethite is presented, which also includes discussion on surface properties, interfaces, acid-base equilibrium, molecular structure and solid state chemistry. It was seen that many students were able to produce qualitatively correct results for a complex system of real interest and they…

  3. Glycosidation of Methanol with Ribose: An Interdisciplinary Undergraduate Laboratory Experiment

    ERIC Educational Resources Information Center

    Simon, Erin; Cook, Katie; Pritchard, Meredith R.; Stripe, Wayne; Bruch, Martha; Bendinskas, Kestutis

    2010-01-01

    This exercise provides students hands-on experience with the topics of glycosidation, hemiacetal and acetal formation, proton nuclear magnetic resonance ([superscript 1]H NMR) spectroscopy, and kinetic and thermodynamic product formation. In this laboratory experiment, the methyl acetal of ribose is synthesized, and the kinetic and thermodynamic…

  4. Vesicle Stability and Dynamics: An Undergraduate Biochemistry Laboratory

    ERIC Educational Resources Information Center

    Del Bianco, Cristina; Torino, Domenica; Mansy, Sheref S.

    2014-01-01

    A laboratory exercise is described that helps students learn about lipid self-assembly by making vesicles under different solution conditions. Concepts covering the chemical properties of different lipids, the dynamics of lipids, and vesicle stability are explored. Further, the described protocol is easy and cheap to implement. One to two…

  5. Development of Sensorial Experiments and Their Implementation into Undergraduate Laboratories

    ERIC Educational Resources Information Center

    Bromfield Lee, Deborah Christina

    2009-01-01

    "Visualization" of chemical phenomena often has been limited in the teaching laboratories to the sense of sight. We have developed chemistry experiments that rely on senses other than eyesight to investigate chemical concepts, make quantitative determinations, and familiarize students with chemical techniques traditionally designed using only…

  6. Vectors and Fomites: An Investigative Laboratory for Undergraduates.

    ERIC Educational Resources Information Center

    Adamo, Joseph A.; Gealt, Michael A.

    1996-01-01

    Presents a laboratory model system for introductory microbiology students that involves hands-on studies of bacteria vectored in soil nematodes. Describes a series of experiments designed to demonstrate vector-fomite transmission, bacterial survival, and disinfectant activity. Introduces the concept of genetically engineered microorganisms and the…

  7. An Undergraduate Vacuum Ultraviolet Spectroscopy Laboratory at Georgia Tech.

    ERIC Educational Resources Information Center

    Stevenson, James R.; Bartlett, Roger J.

    Experimental techniques are taught in a laboratory course designed with some student options available. Eight experiments which use vacuum systems, radiation sources, dispersion and detection systems are outlined. A course outline and time table are given. The final examination is described as 30 minutes of individual practical work and dialogue…

  8. An Enzyme Kinetics Experiment for the Undergraduate Organic Chemistry Laboratory

    ERIC Educational Resources Information Center

    Olsen, Robert J.; Olsen, Julie A.; Giles, Greta A.

    2010-01-01

    An experiment using [superscript 1]H NMR spectroscopy to observe the kinetics of the acylase 1-catalyzed hydrolysis of "N"-acetyl-DL-methionine has been developed for the organic laboratory. The L-enantiomer of the reactant is hydrolyzed completely in less than 2 h, and [superscript 1]H NMR spectroscopic data from a single sample can be worked up…

  9. Blended Learning within an Undergraduate Exercise Physiology Laboratory

    ERIC Educational Resources Information Center

    Elmer, Steven J.; Carter, Kathryn R.; Armga, Austin J.; Carter, Jason R.

    2016-01-01

    In physiological education, blended course formats (integration of face-to-face and online instruction) can facilitate increased student learning, performance, and satisfaction in classroom settings. There is limited evidence on the effectiveness of using blending course formats in laboratory settings. We evaluated the impact of blended learning…

  10. Creatine Synthesis: An Undergraduate Organic Chemistry Laboratory Experiment

    ERIC Educational Resources Information Center

    Smith, Andri L.; Tan, Paula

    2006-01-01

    Students in introductory chemistry classes typically appreciate seeing the connection between course content and the "real world". For this reason, we have developed a synthesis of creatine monohydrate--a popular supplement used in sports requiring short bursts of energy--for introductory organic chemistry laboratory courses. Creatine monohydrate…

  11. A Green Enantioselective Aldol Condensation for the Undergraduate Organic Laboratory

    ERIC Educational Resources Information Center

    Bennett, George D.

    2006-01-01

    A number of laboratory exercises for the organic chemistry curriculum that emphasize enantioselective synthesis of the aldol condensation which involves the proline-catalyzed condensation between acetone and isobutyraldehyde are explored. The experiment illustrates some of the trade-offs involved in green chemistry like the use of acetone in large…

  12. Commentary: Why Abandoning Undergraduate Laboratories Is Not an Option

    ERIC Educational Resources Information Center

    Costa, Manuel Joao

    2010-01-01

    Laboratory exercises (labs) are sometimes regarded as dispensable in biochemistry and molecular biology (BMB) education for various reasons including a combination of increased class costs and small budget allocations, pressing demands for more time to lecture to fit in new BMB discoveries within constant time span of courses, and the fact that…

  13. A Thermal Management of Electronics Course and Laboratory for Undergraduates

    ERIC Educational Resources Information Center

    Okamoto, Nicole; Hsu, Tai-Ran; Bash, Cullen E.

    2009-01-01

    A novel thermal management of electronics course with an associated laboratory has been developed for mechanical, electrical, and computer engineering students. The lecture topics, term project, computer modeling project, and six associated experiments that were built from scratch are described. Over half of the course lectures as well as all lab…

  14. Using Capillary Electrophoresis to Determine the Purity of Acetylsalicylic Acid Synthesized in the Undergraduate Laboratory

    NASA Astrophysics Data System (ADS)

    Welder, Frank; Colyer, Christa L.

    2001-11-01

    Capillary electrophoresis (CE), although a powerful analytical tool, has found only limited application in undergraduate laboratory study. In an effort to expose freshman and sophomore chemistry students to this technique, thereby giving them practical instrumental experience early in their careers, we propose to use CE in the analysis of student-synthesized acetylsalicylic acid (ASA). The synthesis of ASA from salicylic acid (SA) is a routine undergraduate laboratory, although students rarely have the opportunity to test the purity of their product. The CE method described herein provides students with a method to test purity and yield of their product and to determine the effect of aging on their sample. CE can accomplish this in a short period of time, with minimal disruption to the regular laboratory curriculum. Optimized separation conditions, limits of detection, and linear range for ASA and SA are also given.

  15. In Situ Techniques for Monitoring Electrochromism: An Advanced Laboratory Experiment

    ERIC Educational Resources Information Center

    Saricayir, Hakan; Uce, Musa; Koca, Atif

    2010-01-01

    This experiment employs current technology to enhance and extend existing lab content. The basic principles of spectroscopic and electroanalytical techniques and their use in determining material properties are covered in some detail in many undergraduate chemistry programs. However, there are limited examples of laboratory experiments with in…

  16. The impact of collaborative groups versus individuals in undergraduate inquiry-based astronomy laboratory learning exercises

    NASA Astrophysics Data System (ADS)

    Sibbernsen, Kendra J.

    One of the long-standing general undergraduate education requirements common to many colleges and universities is a science course with a laboratory experience component. One of the objectives frequently included in the description of most of these courses is that a student will understand the nature and processes of scientific inquiry. However, recent research has shown that learners in traditional undergraduate science laboratory environments are not developing a sufficiently meaningful understanding of scientific inquiry. Recently, astronomy laboratory activities have been developed that intentionally scaffold a student from guided activities to open inquiry ones and preliminary results show that these laboratories are successful for supporting students to understand the nature of scientific inquiry (Slater, S., Slater, T. F., & Shaner, 2008). This mixed-method quasi-experimental study was designed to determine how students in an undergraduate astronomy laboratory increase their understanding of inquiry working in relative isolation compared to working in small collaborative learning groups. The introductory astronomy laboratory students in the study generally increased their understanding of scientific inquiry over the course of the semester and this held true similarly for students working in groups and students working individually in the laboratories. This was determined by the examining the change in responses from the pretest to the posttest administration of the Views of Scientific Inquiry (VOSI) survey, the increase in scores on laboratory exercises, and observations from the instructor. Because the study was successful in determining that individuals in the astronomy laboratory do as well at understanding inquiry as those who complete their exercises in small groups, it would be appropriate to offer these inquiry-based exercises in an online format.

  17. Heterocycles and Reactive Intermediates in the Undergraduate Organic Lab.

    ERIC Educational Resources Information Center

    Bowles, K. Dean; And Others

    1985-01-01

    Background information, procedures used, and typical results obtained are provided for experiments involving the nitrile oxide cycloaddition with enamines. The experiment is suitable for advanced undergraduate organic laboratories or beginning undergraduate research. (JN)

  18. Holographic study of a vibrating bell: An undergraduate laboratory experiment

    NASA Astrophysics Data System (ADS)

    Menou, Kristen; Audit, Benjamin; Boutillon, Xavier; Vach, Holger

    1998-05-01

    An experiment combining holography and musical acoustics is described. Structures of vibration modes of a bell are visualized by time-average holography under either acoustical or mechanical excitation. The vibration amplitude as measured by an accelerometer shows very good quantitative agreement with that determined from our holograms by fringe counting. An effect of degenerate level separation is shown in the mechanical case. It is argued that this experiment is not only very inexpensive for a physics laboratory already equipped for holography, but that it also strongly stimulates students to deepen their insight into a variety of different topics in applied physics.

  19. Eagleworks Laboratories: Advanced Propulsion Physics Research

    NASA Technical Reports Server (NTRS)

    White, Harold; March, Paul; Williams, Nehemiah; ONeill, William

    2011-01-01

    NASA/JSC is implementing an advanced propulsion physics laboratory, informally known as "Eagleworks", to pursue propulsion technologies necessary to enable human exploration of the solar system over the next 50 years, and enabling interstellar spaceflight by the end of the century. This work directly supports the "Breakthrough Propulsion" objectives detailed in the NASA OCT TA02 In-space Propulsion Roadmap, and aligns with the #10 Top Technical Challenge identified in the report. Since the work being pursued by this laboratory is applied scientific research in the areas of the quantum vacuum, gravitation, nature of space-time, and other fundamental physical phenomenon, high fidelity testing facilities are needed. The lab will first implement a low-thrust torsion pendulum (<1 uN), and commission the facility with an existing Quantum Vacuum Plasma Thruster. To date, the QVPT line of research has produced data suggesting very high specific impulse coupled with high specific force. If the physics and engineering models can be explored and understood in the lab to allow scaling to power levels pertinent for human spaceflight, 400kW SEP human missions to Mars may become a possibility, and at power levels of 2MW, 1-year transit to Neptune may also be possible. Additionally, the lab is implementing a warp field interferometer that will be able to measure spacetime disturbances down to 150nm. Recent work published by White [1] [2] [3] suggests that it may be possible to engineer spacetime creating conditions similar to what drives the expansion of the cosmos. Although the expected magnitude of the effect would be tiny, it may be a "Chicago pile" moment for this area of physics.

  20. Predicting Performance in an Advanced Undergraduate Geological Field Camp Experience

    ERIC Educational Resources Information Center

    Dykas, Matthew J.; Valentino, David W.

    2016-01-01

    This study examined the factors that contribute to students' success in conducting geological field work. Undergraduate students (n = 49; 51% female; mean age = 22 y) who were enrolled in the 5-wk State University of New York at Oswego (SUNY Oswego) geology field program volunteered to participate in this study. At the beginning of the field…

  1. Advancing STEM Undergraduate Learning: Preparing the Nation's Future Faculty

    ERIC Educational Resources Information Center

    Pfund, Christine; Mathieu, Robert; Austin, Ann; Connolly, Mark; Manske, Brian; Moore, Katie

    2012-01-01

    Graduate students and post-doctoral scholars at research universities will shape the future of undergraduate education in the natural and social sciences, technology, engineering, and mathematics (the STEM disciplines) in the United States. In 2009 alone, more than 41,000 doctorates were awarded in STEM fields, and if employment trends hold,…

  2. Two ESR Systems for the Advanced Undergraduate Laboratory

    ERIC Educational Resources Information Center

    Serianz, Art; And Others

    1976-01-01

    Describes the preparation of two radical systems that are stable at ambient temperatures and give reproducibly well-resolved spectra without careful control of temperature or vacuum line degassing of oxygen. (MLH)

  3. An undergraduate laboratory activity on molecular dynamics simulations.

    PubMed

    Spitznagel, Benjamin; Pritchett, Paige R; Messina, Troy C; Goadrich, Mark; Rodriguez, Juan

    2016-01-01

    Vision and Change [AAAS, 2011] outlines a blueprint for modernizing biology education by addressing conceptual understanding of key concepts, such as the relationship between structure and function. The document also highlights skills necessary for student success in 21st century Biology, such as the use of modeling and simulation. Here we describe a laboratory activity that allows students to investigate the dynamic nature of protein structure and function through the use of a modeling technique known as molecular dynamics (MD). The activity takes place over two lab periods that are 3 hr each. The first lab period unpacks the basic approach behind MD simulations, beginning with the kinematic equations that all bioscience students learn in an introductory physics course. During this period students are taught rudimentary programming skills in Python while guided through simple modeling exercises that lead up to the simulation of the motion of a single atom. In the second lab period students extend concepts learned in the first period to develop skills in the use of expert MD software. Here students simulate and analyze changes in protein conformation resulting from temperature change, solvation, and phosphorylation. The article will describe how these activities can be carried out using free software packages, including Abalone and VMD/NAMD.

  4. A writing-intensive, methods-based laboratory course for undergraduates.

    PubMed

    Colabroy, Keri L

    2011-01-01

    Engaging undergraduate students in designing and executing original research should not only be accompanied by technique training but also intentional instruction in the critical analysis and writing of scientific literature. The course described here takes a rigorous approach to scientific reading and writing using primary literature as the model while simultaneously integrating laboratory instruction on basic enzyme purification and characterization, followed by 6 weeks of laboratory dedicated to student-designed original research projects. In the preparation and execution of their original projects, students engage in analysis of the primary literature, proposal writing, peer review, manuscript preparation, and oral presentation. The result is a comprehensive and challenging course that teaches third- and fourth-year undergraduates what it means to "think and work like a scientist."

  5. National Laboratory for Advanced Scientific Visualization at UNAM - Mexico

    NASA Astrophysics Data System (ADS)

    Manea, Marina; Constantin Manea, Vlad; Varela, Alfredo

    2016-04-01

    In 2015, the National Autonomous University of Mexico (UNAM) joined the family of Universities and Research Centers where advanced visualization and computing plays a key role to promote and advance missions in research, education, community outreach, as well as business-oriented consulting. This initiative provides access to a great variety of advanced hardware and software resources and offers a range of consulting services that spans a variety of areas related to scientific visualization, among which are: neuroanatomy, embryonic development, genome related studies, geosciences, geography, physics and mathematics related disciplines. The National Laboratory for Advanced Scientific Visualization delivers services through three main infrastructure environments: the 3D fully immersive display system Cave, the high resolution parallel visualization system Powerwall, the high resolution spherical displays Earth Simulator. The entire visualization infrastructure is interconnected to a high-performance-computing-cluster (HPCC) called ADA in honor to Ada Lovelace, considered to be the first computer programmer. The Cave is an extra large 3.6m wide room with projected images on the front, left and right, as well as floor walls. Specialized crystal eyes LCD-shutter glasses provide a strong stereo depth perception, and a variety of tracking devices allow software to track the position of a user's hand, head and wand. The Powerwall is designed to bring large amounts of complex data together through parallel computing for team interaction and collaboration. This system is composed by 24 (6x4) high-resolution ultra-thin (2 mm) bezel monitors connected to a high-performance GPU cluster. The Earth Simulator is a large (60") high-resolution spherical display used for global-scale data visualization like geophysical, meteorological, climate and ecology data. The HPCC-ADA, is a 1000+ computing core system, which offers parallel computing resources to applications that requires

  6. Integrating bio-inorganic and analytical chemistry into an undergraduate biochemistry laboratory.

    PubMed

    Erasmus, Daniel J; Brewer, Sharon E; Cinel, Bruno

    2015-01-01

    Undergraduate laboratories expose students to a wide variety of topics and techniques in a limited amount of time. This can be a challenge and lead to less exposure to concepts and activities in bio-inorganic chemistry and analytical chemistry that are closely-related to biochemistry. To address this, we incorporated a new iron determination by atomic absorption spectroscopy exercise as part of a five-week long laboratory-based project on the purification of myoglobin from beef. Students were required to prepare samples for chemical analysis, operate an atomic absorption spectrophotometer, critically evaluate their iron data, and integrate these data into a study of myoglobin.

  7. Known structure, unknown function: An inquiry-based undergraduate biochemistry laboratory course.

    PubMed

    Gray, Cynthia; Price, Carol W; Lee, Christopher T; Dewald, Alison H; Cline, Matthew A; McAnany, Charles E; Columbus, Linda; Mura, Cameron

    2015-01-01

    Undergraduate biochemistry laboratory courses often do not provide students with an authentic research experience, particularly when the express purpose of the laboratory is purely instructional. However, an instructional laboratory course that is inquiry- and research-based could simultaneously impart scientific knowledge and foster a student's research expertise and confidence. We have developed a year-long undergraduate biochemistry laboratory curriculum wherein students determine, via experiment and computation, the function of a protein of known three-dimensional structure. The first half of the course is inquiry-based and modular in design; students learn general biochemical techniques while gaining preparation for research experiments in the second semester. Having learned standard biochemical methods in the first semester, students independently pursue their own (original) research projects in the second semester. This new curriculum has yielded an improvement in student performance and confidence as assessed by various metrics. To disseminate teaching resources to students and instructors alike, a freely accessible Biochemistry Laboratory Education resource is available at http://biochemlab.org.

  8. Known structure, unknown function: An inquiry‐based undergraduate biochemistry laboratory course

    PubMed Central

    Gray, Cynthia; Price, Carol W.; Lee, Christopher T.; Dewald, Alison H.; Cline, Matthew A.; McAnany, Charles E.

    2015-01-01

    Abstract Undergraduate biochemistry laboratory courses often do not provide students with an authentic research experience, particularly when the express purpose of the laboratory is purely instructional. However, an instructional laboratory course that is inquiry‐ and research‐based could simultaneously impart scientific knowledge and foster a student's research expertise and confidence. We have developed a year‐long undergraduate biochemistry laboratory curriculum wherein students determine, via experiment and computation, the function of a protein of known three‐dimensional structure. The first half of the course is inquiry‐based and modular in design; students learn general biochemical techniques while gaining preparation for research experiments in the second semester. Having learned standard biochemical methods in the first semester, students independently pursue their own (original) research projects in the second semester. This new curriculum has yielded an improvement in student performance and confidence as assessed by various metrics. To disseminate teaching resources to students and instructors alike, a freely accessible Biochemistry Laboratory Education resource is available at http://biochemlab.org. © 2015 The Authors Biochemistry and Molecular Biology Education published by Wiley Periodicals, Inc. on behalf of International Union of Biochemistry and Molecular Biology, 43(4):245–262, 2015. PMID:26148241

  9. [Rehabilitation in undergraduate education and advanced professional training of the participating professional groups].

    PubMed

    Mau, Wilfried; Bengel, Jürgen; Pfeifer, Klaus

    2017-02-14

    In the German health care system, multiprofessional and coordinated rehabilitation care provides support for successful disease management. Against a background of the conditions and strong dynamics of the provision, this article gives an overview of some of the pertinent developments in rehabilitation-related undergraduate education and advanced professional training of physicians, psychologists, and exercise therapy professions in Germany. Frequently, there are few provisions and great variation between different locations. New conditions, such as the National Competence-Based Learning Objectives for Undergraduate Medical Education, the National Guidelines for Graduate Medical Education, and the ongoing reform of the psychotherapists' law emphasizing training in psychotherapy at university, allow the expectation of a positive effect on the competence of rehabilitation professionals. Education in physiotherapy is developing according to international standards aimed at improved evidence-based care. For the widely evidence-based undergraduate education and advanced professional training in sports and exercise therapy better profiling and professionalization should be sought.

  10. Advanced Simulation in Undergraduate Pilot Training: Motion System Development

    DTIC Science & Technology

    1975-10-01

    Resources Laboratory * a~ October 1975 DISTRIBUTED BY: National Technical Infolmation Service U. S. DEPARTMENT OF COMMERCE 329055 AFHRL-TR-75.59(11) AIR...1911 - March 1975 0 A plloved (or publ( rele.Le; ditribution unlii h¢uted. E S LABORATORY NATIONAL TECHNICAL I INFORMATION SERVICEIJS D-pvt-f Of ,CU...Force IHuman Resources Laboratory (AFSC), Wright-Patterson Air Force Base. Ohio 45433. Mr. Don R. Gur.i Simulation Techniques Branch. was tile contract

  11. A model system for the study of gene expression in the undergraduate laboratory.

    PubMed

    Hargadon, Kristian M

    2016-07-08

    The flow of genetic information from DNA to RNA to protein, otherwise known as the "central dogma" of biology, is one of the most basic and overarching concepts in the biological sciences. Nevertheless, numerous studies have reported student misconceptions at the undergraduate level of this fundamental process of gene expression. This study reports on the efficacy of a model system for teaching gene expression in the undergraduate laboratory. A student-centered investigation of Tgfb1 gene expression in two murine melanoma cell lines was used to emphasize not only the process of gene expression but also various research methods for studying this phenomenon. Traditional RT-PCR, quantitative real-time RT-PCR, and flow cytometry-based in situ hybridization assays were employed to study expression of this immunosuppressive cytokine gene in the highly tumorigenic B16-F1 melanoma cell line and the poorly tumorigenic D5.1G4 melanoma cell line, both at the population and single-cell levels. A pre- and post-laboratory assessment instrument demonstrated the utility of this model system in enhancing student learning both of content related to gene expression and of research methods and data analysis skills. The pedagogical approach described in this study is therefore an effective way to improve the teaching and learning of gene expression at the undergraduate level. © 2016 by The International Union of Biochemistry and Molecular Biology, 44(4):397-404, 2016.

  12. Hormones and Antibiotics in Nature: A Laboratory Module Designed to Broaden Undergraduate Perspectives on Typically Human-Centered Topics†

    PubMed Central

    Weber, Carolyn F.

    2014-01-01

    Bringing discovery-based research into undergraduate laboratory courses increases student motivation and learning gains over traditional exercises that merely teach technique or demonstrate well-documented phenomena. Laboratory experiences are further enhanced when they are designed to challenge student perspectives on topics relevant to their lives. To this end, a laboratory module on antibiotics and hormones, which are generally discussed in the context of human health, was developed for students to explore the multifaceted roles of antibiotics and hormones in nature (e.g. interspecies communication) via reading primary scientific literature and performing discovery-based experiments. The main objective of this module was to increase the general biological literacy of students as determined by their ability to connect the Five Core Concepts of Biological Literacy (American Association for the Advancement of Science, Vision and Change in Undergraduate Education: A Call to Action, 2011) to the topics “hormones” and “antibiotics” in pre- and postmodule surveys. After discussing unpublished research findings, cell biology students performed experiments demonstrating that: 1) fungi may promote fern growth via hormone production, 2) novel bacterial isolates in the genus Streptomyces produce antifungal compounds, and 3) subinhibitory antibiotic concentrations may enhance soil bacterial growth. The third finding provided evidence supporting a hypothesis framed in a scientific article that students read and discussed. Student perspectives on premodule surveys focused on roles of hormones and antibiotics in the human body (e.g. development, fighting infection), but their broadened postmodule perspectives encompassed the roles of these molecules in organismal communication and possibly the evolution of multicellularity. PMID:25574294

  13. Hormones and antibiotics in nature: a laboratory module designed to broaden undergraduate perspectives on typically human-centered topics.

    PubMed

    Weber, Carolyn F

    2014-12-01

    Bringing discovery-based research into undergraduate laboratory courses increases student motivation and learning gains over traditional exercises that merely teach technique or demonstrate well-documented phenomena. Laboratory experiences are further enhanced when they are designed to challenge student perspectives on topics relevant to their lives. To this end, a laboratory module on antibiotics and hormones, which are generally discussed in the context of human health, was developed for students to explore the multifaceted roles of antibiotics and hormones in nature (e.g. interspecies communication) via reading primary scientific literature and performing discovery-based experiments. The main objective of this module was to increase the general biological literacy of students as determined by their ability to connect the Five Core Concepts of Biological Literacy (American Association for the Advancement of Science, Vision and Change in Undergraduate Education: A Call to Action, 2011) to the topics "hormones" and "antibiotics" in pre- and postmodule surveys. After discussing unpublished research findings, cell biology students performed experiments demonstrating that: 1) fungi may promote fern growth via hormone production, 2) novel bacterial isolates in the genus Streptomyces produce antifungal compounds, and 3) subinhibitory antibiotic concentrations may enhance soil bacterial growth. The third finding provided evidence supporting a hypothesis framed in a scientific article that students read and discussed. Student perspectives on premodule surveys focused on roles of hormones and antibiotics in the human body (e.g. development, fighting infection), but their broadened postmodule perspectives encompassed the roles of these molecules in organismal communication and possibly the evolution of multicellularity.

  14. A May American Economic Review Papers Seminar and an Analytic Project for Advanced Undergraduates

    ERIC Educational Resources Information Center

    Elliott, Catherine S.

    2004-01-01

    The author describes two learning activities for teaching economics at the advanced undergraduate level: a May American Economic Review (AER) papers seminar and an analytic project. Both activities help students learn to "do economics." The May AER papers seminar promotes in-depth synthesis and interpretation on the basis of printed session papers…

  15. Use of IBM's Advanced Control System in Undergraduate Process Control Education.

    ERIC Educational Resources Information Center

    Koppel, Lowell B.; Sullivan, Gerald R.

    1986-01-01

    This article: (1) traces some of the history behind the International Business Machines (IBM) and academic arrangement; (2) describes the Advanced Control System and how it is used in undergraduate process control courses; (3) discusses benefits to students and teachers; and (4) summarizes future plans. (JN)

  16. Curriculum for the Twenty-First Century: Recent Advances in Economic Theory and Undergraduate Economics

    ERIC Educational Resources Information Center

    Ferguson, William D.

    2011-01-01

    Undergraduate economics lags behind cutting-edge economic theory. The author briefly reviews six related advances that profoundly extend and deepen economic analysis: game-theoretic modeling, collective-action problems, information economics and contracting, social preference theory, conceptualizing rationality, and institutional theory. He offers…

  17. ELISA and GC-MS as Teaching Tools in the Undergraduate Environmental Analytical Chemistry Laboratory

    NASA Astrophysics Data System (ADS)

    Wilson, Ruth I.; Mathers, Dan T.; Mabury, Scott A.; Jorgensen, Greg M.

    2000-12-01

    An undergraduate experiment for the analysis of potential water pollutants is described. Students are exposed to two complementary techniques, ELISA and GC-MS, for the analysis of a water sample containing atrazine, desethylatrazine, and simazine. Atrazine was chosen as the target analyte because of its wide usage in North America and its utility for students to predict environmental degradation products. The water sample is concentrated using solid-phase extraction for GC-MS, or diluted and analyzed using a competitive ELISA test kit for atrazine. The nature of the water sample is such that students generally find that ELISA gives an artificially high value for the concentration of atrazine. Students gain an appreciation for problems associated with measuring pollutants in the aqueous environment: sensitivity, accuracy, precision, and ease of analysis. This undergraduate laboratory provides an opportunity for students to learn several new analysis and sample preparation techniques and to critically evaluate these methods in terms of when they are most useful.

  18. Pencil-and-Paper Neural Networks: An Undergraduate Laboratory Exercise in Computational Neuroscience.

    PubMed

    Crisp, Kevin M; Sutter, Ellen N; Westerberg, Jacob A

    2015-01-01

    Although it has been more than 70 years since McCulloch and Pitts published their seminal work on artificial neural networks, such models remain primarily in the domain of computer science departments in undergraduate education. This is unfortunate, as simple network models offer undergraduate students a much-needed bridge between cellular neurobiology and processes governing thought and behavior. Here, we present a very simple laboratory exercise in which students constructed, trained and tested artificial neural networks by hand on paper. They explored a variety of concepts, including pattern recognition, pattern completion, noise elimination and stimulus ambiguity. Learning gains were evident in changes in the use of language when writing about information processing in the brain.

  19. Using Laboratory Experiments and Circuit Simulation IT Tools in an Undergraduate Course in Analog Electronics

    NASA Astrophysics Data System (ADS)

    Baltzis, Konstantinos B.; Koukias, Konstantinos D.

    2009-12-01

    Laboratory-based courses play a significant role in engineering education. Given the role of electronics in engineering and technology, laboratory experiments and circuit simulation IT tools are used in their teaching in several academic institutions. This paper discusses the characteristics and benefits of both methods. The content and structure of an introductory laboratory course in analog electronics is described. The aim of the course is the better understanding of the basic principles of analog electronic circuits without the need of specific technical and computer skills. The impact of the proposed method on the learning process is investigated. The evaluation of our proposal was based on both quantitative and qualitative data. Interesting conclusions about the teaching of electronics in undergraduate education are finally drawn.

  20. Safety in the Chemical Laboratory: An Undergraduate Chemical Laboratory Safety Course.

    ERIC Educational Resources Information Center

    Nicholls, L. Jewel

    1982-01-01

    Describes a two-quarter hour college chemistry course focusing on laboratory safety. Includes lists of topics/assignments, problem sets (toxicology, storage, and energy) and videotapes, films, and slide sets used in the course. (JN)

  1. Safety in the Chemical Laboratory: Learning How to Run Safer Undergraduate Laboratories.

    ERIC Educational Resources Information Center

    Mohrig, Jerry R.

    1983-01-01

    Discusses responsibilities for providing safe experiments and for teaching about safety. Provides lists of references on chemical safety and regulated/potential carcinogens. Also discusses general laboratory safety procedures including waste disposal and recycling of solvents. (JM)

  2. Integrating responsible conduct of research education into undergraduate biochemistry and molecular biology laboratory curricula.

    PubMed

    Hendrickson, Tamara L

    2015-01-01

    Recently, a requirement for directed responsible conduct in research (RCR) education has become a priority in the United States and elsewhere. In the US, both the National Institutes of Health and the National Science Foundation require RCR education for all students who are financially supported by federal awards. The guidelines produced by these agencies offer useful templates for the introduction of RCR materials into courses worldwide. Many academic programs already offer courses or workshops in RCR for their graduate students and for undergraduate science majors and/or researchers. Introducing RCR into undergraduate biochemistry and molecular biology laboratory curricula is another, highly practical way that students can be exposed to these important topics. In fact, a strong argument can be made for integrating RCR into laboratory courses because these classes often introduce students to a scientific environment like that they might encounter in their careers after graduation. This article focuses on general strategies for incorporating explicit RCR education into biochemistry and molecular biology laboratory coursework using the topics suggested by NIH as a starting point.

  3. Chromatin Isolation and DNA Sequence Analysis in Large Undergraduate Laboratory Sections

    NASA Astrophysics Data System (ADS)

    Hagerman, Ann E.

    1999-10-01

    A pair of exercises that introduce undergraduate students to basic techniques and concepts of molecular biology and that are appropriate for classes with large enrollments are described. One exercise is a simple laboratory experiment in which chromatin is isolated from chicken liver and is resolved into histone proteins and DNA by ion-exchange chromatography. The other is a series of computer simulations that introduce DNA sequencing, mapping, and sequence analysis to the students. The final step of the simulation is submission of a sequence to a database on the World Wide Web for identification of the protein product of the gene.

  4. Development of an undergraduate optics laboratory based on the analysis of digital images

    NASA Astrophysics Data System (ADS)

    Ramil, Alberto; López, Ana J.; Fiorucci, M. Paula; Vincitorio, Fabio

    2014-07-01

    The aim of this work is to present an experience based on the use of digital images and computer processing techniques for enhanced optics laboratory teaching aids. The use of digital images offers the possibility of analysing some phenomena quantitatively, which would be very difficult to do with the traditional equipment available in teaching labs. In order to obtain high quality teaching material, a number of practical aspects should be taken into account during the process of image acquisition and subsequent analysis. Examples of quantitative experiments are presented; they cover the usual topics at undergraduate level, both geometrical and physical optics and even spectral analysis of the light.

  5. Identification of Forensic Samples via Mitochondrial DNA in the Undergraduate Biochemistry Laboratory

    NASA Astrophysics Data System (ADS)

    Millard, Julie T.; Pilon, André M.

    2003-04-01

    A recent forensic approach for identification of unknown biological samples is mitochondrial DNA (mtDNA) sequencing. We describe a laboratory exercise suitable for an undergraduate biochemistry course in which the polymerase chain reaction is used to amplify a 440 base pair hypervariable region of human mtDNA from a variety of "crime scene" samples (e.g., teeth, hair, nails, cigarettes, envelope flaps, toothbrushes, and chewing gum). Amplification is verified via agarose gel electrophoresis and then samples are subjected to cycle sequencing. Sequence alignments are made via the program CLUSTAL W, allowing students to compare samples and solve the "crime."

  6. Results of Laboratory Testing of Advanced Power Strips: Preprint

    SciTech Connect

    Earle, L.; Sparn, B.

    2012-08-01

    This paper describes the results of a laboratory investigation to evaluate the technical performance of advanced power strip (APS) devices when subjected to a range of home entertainment center and home office usage scenarios.

  7. Better understanding of homologous recombination through a 12-week laboratory course for undergraduates majoring in biotechnology.

    PubMed

    Li, Ming; Shen, Xiaodong; Zhao, Yan; Hu, Xiaomei; Hu, Fuquan; Rao, Xiancai

    2017-03-17

    Homologous recombination, a central concept in biology, is defined as the exchange of DNA strands between two similar or identical nucleotide sequences. Unfortunately, undergraduate students majoring in biotechnology often experience difficulties in understanding the molecular basis of homologous recombination. In this study, we developed and implemented a 12-week laboratory course for biotechnology undergraduates in which gene targeting in Streptococcus suis was used to facilitate their understanding of the basic concept and process of homologous recombination. Students worked in teams of two to select a gene of interest to create a knockout mutant using methods that relied on homologous recombination. By integrating abstract knowledge and practice in the process of scientific research, students gained hands-on experience in molecular biology techniques while learning about the principle and process of homologous recombination. The learning outcomes and survey-based assessment demonstrated that students substantially enhanced their understanding of how homologous recombination could be used to study gene function. Overall, the course was very effective for helping biotechnology undergraduates learn the theory and application of homologous recombination, while also yielding positive effects in developing confidence and scientific skills for future work in research. © 2017 by The International Union of Biochemistry and Molecular Biology, 2017.

  8. Undergraduate Laboratory Module for Implementing ELISA on the High Performance Microfluidic Platform.

    PubMed

    Giri, Basant; Peesara, Ravichander R; Yanagisawa, Naoki; Dutta, Debashis

    Implementing enzyme-linked immunosorbent assays (ELISA) in microchannels offers several advantages over its traditional microtiter plate-based format, including a reduced sample volume requirement, shorter incubation period, and greater sensitivity. Moreover, microfluidic ELISA platforms are inexpensive to fabricate and allow integration of analytical procedures, such as sample preconcentration, that further enhance the performance of the immunoassay. In view of the scientific potential of microfluidic ELISAs, inclusion of this technique into an undergraduate curriculum is valuable in preparing the next generation of scientists and engineers. Here, an experimental module is presented for this immunoassay method that can be completed in an undergraduate laboratory setting within two 3-h periods (including all incubation and data analyses procedures) using only a microliter of sample and reagents per assay. In addition to acquainting students with the microfluidic technology, the reported module provides training in quantitating ELISAs using the kinetic format of the assay. Furthermore, it offers a useful educational tool for introducing undergraduates to basic image analysis techniques, as well as signal-to-noise ratio and limit of detection calculations that are valuable in characterizing any analytical method.

  9. Undergraduate Laboratory Module for Implementing ELISA on the High Performance Microfluidic Platform

    PubMed Central

    Giri, Basant; Peesara, Ravichander R.; Yanagisawa, Naoki; Dutta, Debashis

    2015-01-01

    Implementing enzyme-linked immunosorbent assays (ELISA) in microchannels offers several advantages over its traditional microtiter plate-based format, including a reduced sample volume requirement, shorter incubation period, and greater sensitivity. Moreover, microfluidic ELISA platforms are inexpensive to fabricate and allow integration of analytical procedures, such as sample preconcentration, that further enhance the performance of the immunoassay. In view of the scientific potential of microfluidic ELISAs, inclusion of this technique into an undergraduate curriculum is valuable in preparing the next generation of scientists and engineers. Here, an experimental module is presented for this immunoassay method that can be completed in an undergraduate laboratory setting within two 3-h periods (including all incubation and data analyses procedures) using only a microliter of sample and reagents per assay. In addition to acquainting students with the microfluidic technology, the reported module provides training in quantitating ELISAs using the kinetic format of the assay. Furthermore, it offers a useful educational tool for introducing undergraduates to basic image analysis techniques, as well as signal-to-noise ratio and limit of detection calculations that are valuable in characterizing any analytical method. PMID:26052160

  10. Microwave-Enhanced Organic Syntheses for the Undergraduate Laboratory: Diels-Alder Cycloaddition, Wittig Reaction, and Williamson Ether Synthesis

    ERIC Educational Resources Information Center

    Baar, Marsha R.; Falcone, Danielle; Gordon, Christopher

    2010-01-01

    Microwave heating enhanced the rate of three reactions typically performed in our undergraduate organic chemistry laboratory: a Diels-Alder cycloaddition, a Wittig salt formation, and a Williamson ether synthesis. Ninety-minute refluxes were shortened to 10 min using a laboratory-grade microwave oven. In addition, yields improved for the Wittig…

  11. Using an ePortfolio System as an Electronic Laboratory Notebook in Undergraduate Biochemistry and Molecular Biology Practical Classes

    ERIC Educational Resources Information Center

    Johnston, Jill; Kant, Sashi; Gysbers, Vanessa; Hancock, Dale; Denyer, Gareth

    2014-01-01

    Despite many apparent advantages, including security, back-up, remote access, workflow, and data management, the use of electronic laboratory notebooks (ELNs) in the modern research laboratory is still developing. This presents a challenge to instructors who want to give undergraduate students an introduction to the kinds of data curation and…

  12. So These Numbers Really Mean Something? A Role Playing Scenario-Based Approach to the Undergraduate Instrumental Analysis Laboratory

    ERIC Educational Resources Information Center

    Grannas, Amanda M.; Lagalante, Anthony F.

    2010-01-01

    A new curricular approach in our undergraduate second-year instrumental analysis laboratory was implemented. Students work collaboratively on scenarios in diverse fields including pharmaceuticals, forensics, gemology, art conservation, and environmental chemistry. Each laboratory section (approximately 12 students) is divided into three groups…

  13. Federal Support for Undergraduate Laboratory Work in Physics. A Statement by the American Association of Physics Teachers.

    ERIC Educational Resources Information Center

    American Association of Physics Teachers, College Park, MD.

    The teaching laboratory in physics departments in colleges and universities is a source of great potential strength in undergraduate education. Recent surveys and conferences, have identified inadequate teaching equipment and laboratory development. This report reviews these problems and offers suggestions for an enhanced federal effort to solve…

  14. "Anisakis Simplex" Infection in Mackerel: A Reliable Laboratory Exercise to Demonstrate Important Principles in Parasitology to Undergraduates

    ERIC Educational Resources Information Center

    Coombs, I.; Tatner, M.; Paterson, V.

    2013-01-01

    Practical laboratory work in parasitology can be very limited, due to the difficulty in maintaining multi-host parasite life cycles, especially for a large, once-yearly undergraduate laboratory class for life science students. The use of mackerel, "Scomber scombrus," bought from a local fishmonger, is an ideal model to investigate important…

  15. Assessing students' ability to critically evaluate evidence in an inquiry-based undergraduate laboratory course.

    PubMed

    Colthorpe, Kay; Mehari Abraha, Hyab; Zimbardi, Kirsten; Ainscough, Louise; Spiers, Jereme G; Chen, Hsiao-Jou Cortina; Lavidis, Nickolas A

    2017-03-01

    The ability to critically evaluate and use evidence from one's own work or from primary literature is invaluable to any researcher. These skills include the ability to identify strengths and weakness of primary literature, to gauge the impact of research findings on a field, to identify gaps in a field that require more research, and to contextualize findings within a field. This study developed a model to examine undergraduate science students' abilities to critically evaluate and use evidence through an analysis of laboratory reports from control and experimental groups in nonresearch-aligned and research-aligned inquiry-based laboratory classes, respectively, and contrasted these with published scientific research articles. The reports analyzed (n = 42) showed that students used evidence in a variety of ways, most often referring to literature indirectly, and least commonly highlighting limitations of literature. There were significant positive correlations between grade awarded and the use of references, evidence, and length, but there were no significant differences between control and experimental groups, so data were pooled. The use of evidence in scientific research articles (n = 7) was similar to student reports except that expert authors were more likely to refer to their own results and cite more references. Analysis showed that students, by the completion of the second year of their undergraduate degree, had expertise approaching that of published authors. These findings demonstrate that it is possible to provide valuable broad-scale undergraduate research experiences to all students in a cohort, giving them exposure to the methods and communication processes of research as well as an opportunity to hone their critical evaluation skills.

  16. A laboratory course for teaching laboratory techniques, experimental design, statistical analysis, and peer review process to undergraduate science students.

    PubMed

    Gliddon, C M; J Rosengren, R

    2012-01-01

    This article describes a 13-week laboratory course called Human Toxicology taught at the University of Otago, New Zealand. This course used a guided inquiry based laboratory coupled with formative assessment and collaborative learning to develop in undergraduate students the skills of problem solving/critical thinking, data interpretation and written discussion of results. The laboratory practices were a guided inquiry based around retinol's ability to potentiate acetaminophen-mediated hepatotoxicity. To induce critical thinking, students were given a choice as to which assay they could use to determine how retinol affected acetaminophen hepatotoxicity. Short summaries were handed in following each assay and formed the bases of the formative assessment. To complete the feedback loop, a summative assessment that consisted of all the graphs and concepts from the short summaries were combined into a manuscript. To give the students exposure to science communication, the manuscript had to be written in accordance to the submission guidelines for Toxicological Sciences. Evaluation of this course was determined by a student questionnaire using a Likert scale and students' responses were very favorable. While the subject matter was toxicological centric, the content could be easily modified to suit another subject matter in biochemistry and molecular biology.

  17. Computer based learning in an undergraduate physics laboratory: interfacing and instrument control using Matlab

    NASA Astrophysics Data System (ADS)

    Sharp, J. S.; Glover, P. M.; Moseley, W.

    2007-05-01

    In this paper we describe the recent changes to the curriculum of the second year practical laboratory course in the School of Physics and Astronomy at the University of Nottingham. In particular, we describe how Matlab has been implemented as a teaching tool and discuss both its pedagogical advantages and disadvantages in teaching undergraduate students about computer interfacing and instrument control techniques. We also discuss the motivation for converting the interfacing language that is used in the laboratory from LabView to Matlab. We describe an example of a typical experiment the students are required to complete and we conclude by briefly assessing how the recent curriculum changes have affected both student performance and compliance.

  18. Student perceptions of an upper-level, undergraduate human anatomy laboratory course without cadavers.

    PubMed

    Wright, Shirley J

    2012-01-01

    Several programs in health professional education require or are considering requiring upper-level human anatomy as prerequisite for their applicants. Undergraduate students are confronted with few institutions offering such a course, in part because of the expense and logistical issues associated with a cadaver-based human anatomy course. This study describes the development of and student reactions to an upper-level human anatomy laboratory course for undergraduate students that used a regional approach and contemporary, alternative teaching methods to a cadaver-based course. The alternative pedagogy to deliver the curriculum included use of commercially available, three-dimensional anatomical virtual dissection software, anatomical models coupled with a learning management system to offer Web-based learning, and a new laboratory manual with collaborative exercises designed to develop the student's anatomical skills and collaborative team skills. A Likert-scale survey with open-ended questions was used to ascertain student perceptions of the course and its various aspects. Students perceived that the noncadaver-based, upper-level human anatomy course with an engaging, regional approach is highly valuable in their learning of anatomy. anatomy.

  19. An undergraduate laboratory class using CRISPR/Cas9 technology to mutate Drosophila genes

    PubMed Central

    Adame, Vanesa; Chapapas, Holly; Cisneros, Marilyn; Deaton, Carol; Deichmann, Sophia; Gadek, Chauncey; Lovato, TyAnna L.; Chechenova, Maria B.; Guerin, Paul; Cripps, Richard M.

    2017-01-01

    CRISPR/Cas9 genome editing technology is used in the manipulation of genome sequences and gene expression. Due to the ease and rapidity with which genes can be mutated using CRISPR/Cas9, we sought to determine if a single-semester undergraduate class could be successfully taught, wherein students isolate mutants for specific genes using CRISPR/Cas9. Six students were each assigned a single Drosophila gene, for which no mutants currently exist. Each student designed and created plasmids to encode single guide RNAs that target their selected gene; injected the plasmids into Cas9-expressing embryos, in order to delete the selected gene; carried out a two-generation cross to test for germline transmission of a mutated allele and generate a stable stock of the mutant; and characterized the mutant alleles by PCR and sequencing. Three genes out of six were successfully mutated. Pre- and post- survey evaluations of the students in the class revealed that student attitudes towards their research competencies increased, although the changes were not statistically significant. We conclude that it is feasible to develop a laboratory genome editing class, to provide effective laboratory training to undergraduate students, and to generate mutant lines for use by the broader scientific community. PMID:27009801

  20. An undergraduate laboratory class using CRISPR/Cas9 technology to mutate drosophila genes.

    PubMed

    Adame, Vanesa; Chapapas, Holly; Cisneros, Marilyn; Deaton, Carol; Deichmann, Sophia; Gadek, Chauncey; Lovato, TyAnna L; Chechenova, Maria B; Guerin, Paul; Cripps, Richard M

    2016-05-06

    CRISPR/Cas9 genome editing technology is used in the manipulation of genome sequences and gene expression. Because of the ease and rapidity with which genes can be mutated using CRISPR/Cas9, we sought to determine if a single-semester undergraduate class could be successfully taught, wherein students isolate mutants for specific genes using CRISPR/Cas9. Six students were each assigned a single Drosophila gene, for which no mutants currently exist. Each student designed and created plasmids to encode single guide RNAs that target their selected gene; injected the plasmids into Cas9-expressing embryos, in order to delete the selected gene; carried out a three-generation cross to test for germline transmission of a mutated allele and generate a stable stock of the mutant; and characterized the mutant alleles by PCR and sequencing. Three genes out of six were successfully mutated. Pre- and post- survey evaluations of the students in the class revealed that student attitudes towards their research competencies increased, although the changes were not statistically significant. We conclude that it is feasible to develop a laboratory genome editing class, to provide effective laboratory training to undergraduate students, and to generate mutant lines for use by the broader scientific community. © 2016 by The International Union of Biochemistry and Molecular Biology, 44:263-275, 2016.

  1. The ATLAS project: The effects of a constructionist digital laboratory project on undergraduate laboratory performance.

    PubMed

    Shoepe, Todd C; Cavedon, Dana K; Derian, Joseph M; Levy, Celine S; Morales, Amy

    2015-01-01

    Anatomical education is a dynamic field where developments in the implementation of constructive, situated-learning show promise in improving student achievement. The purpose of this study was to examine the effectiveness of an individualized, technology heavy project in promoting student performance in a combined anatomy and physiology laboratory course. Mixed-methods research was used to compare two cohorts of anatomy laboratories separated by the adoption of a new laboratory atlas project, which were defined as preceding (PRE) and following the adoption of the Anatomical Teaching and Learning Assessment Study (ATLAS; POST). The ATLAS project required the creation of a student-generated, photographic atlas via acquisition of specimen images taken with tablet technology and digital microscope cameras throughout the semester. Images were transferred to laptops, digitally labeled and photo edited weekly, and compiled into a digital book using Internet publishing freeware for final project submission. An analysis of covariance confirmed that student final examination scores were improved (P < 0.05) following the implementation of the laboratory atlas project (PRE, n = 75; POST, n = 90; means ± SE; 74.9 ± 0.9 versus 78.1 ± 0.8, respectively) after controlling for cumulative student grade point average. Analysis of questionnaires collected (n = 68) from the post group suggested students identified with atlas objectives, appreciated the comprehensive value in final examination preparation, and the constructionism involved, but recommended alterations in assignment logistics and the format of the final version. Constructionist, comprehensive term-projects utilizing student-preferred technologies could be used to improve performance toward student learning outcomes.

  2. Ordering patterns for laboratory and radiology tests by students from different undergraduate medical curricula

    PubMed Central

    2013-01-01

    Background The overuse of laboratory tests and radiology imaging and their possible hazards to patients and the health care system is observed with growing concern in the medical community. With this study the authors wished to determine whether ordering patterns for laboratory and radiology tests by medical students close to their graduation are related to undergraduate training. Methods We developed an assessment for near graduates in the setting of a resident’s daily routine including a consultation hour with five simulated patients, three hours for patient work up with simulated distracting tasks, and thirty minutes for reporting of patient management to a supervisor. In 2011, 60 students participated in this assessment: 30 from a vertically integrated (VI) curriculum (Utrecht, The Netherlands) and 30 from a traditional, non-VI curriculum (Hamburg, Germany). We assessed and compared the number of laboratory and radiology requests and correlated the results with the scores participants received from their supervisors for the facet of competence “scientifically and empirically grounded method of working”. Results Students from a VI curriculum used significantly (p < .01) less total laboratory requests (N = 283 versus N = 466) which correlated with their scores for a “scientifically and empirically grounded method of working” (Pearson’s r = .572). A significantly (p < .01) higher number of radiology imaging was ordered with a large effect size (V = .618) by near graduates from a non-VI curriculum (N = 156 versus N = 97) even when this was not supporting the diagnostic process. Conclusion The focused ordering patterns from VI students might be a result of their early exposure to the clinical environment and a different approach to clinical decision making during their undergraduate education which further studies should address in greater detail. PMID:23945311

  3. An advanced laboratory course that emphasizes communication

    NASA Astrophysics Data System (ADS)

    Rieger, Georg

    2012-10-01

    I will introduce a fourth-year laboratory course that has a strong focus on communication skills. The course is meant to give students a preview of how experimental physics is performed in an academic or industrial research lab. The design is such that the course approximates the experience of a graduate student in a research group, which I regard as an ideal learning environment. I will contrast this with the learning experience in a typical first- or second-year lab. Results from a small survey are also presented.

  4. Advances in laboratory geophysics using bender elements

    NASA Astrophysics Data System (ADS)

    Rio, Joao Filipe Meneses Espinheira

    Bender element transducers are used to determine the small-strain shear stiffness, Go, of soil, by determining the velocity of propagation of mechanical waves through tested samples. They are normally used in the laboratory, on their own or incorpo rated in geotechnical equipment such as triaxial cells or oedometers. Different excitation signals and interpretation methods are presently applied, each producing different results. The initial assumptions of unbounded wave propa gation, generally used in bender element testing and inherited from seismic cross-hole testing, are quite crude and do not account for specific boundary conditions, which might explain the lack of reliability of the results. The main objective of this study is to establish the influence of the sample and transducer geometry in the behaviour of a typical bender element test system. Laboratory and numerical tests, supported by a theoretical analytical study, are conducted and the results presented in order to achieve this goal. An independent monitoring of the dynamic behaviour of the bender elements and samples is also carried out. Using a laser velocimeter, capable of recording the motion of the subjects without interference, their dynamic responses can be obtained and their mechanical properties verified. A parametric study dealing with sample geometry is presented, where 24 samples with different geometries are tested. Synthetic rubber is used as a substitute for soft clay, due to the great number of samples involved and the necessity of guarantee the constancy of their properties. The numerical analysis makes use of three-dimensional finite difference models with different geometries. A regressive analysis is possible since the elastic properties of the system are pre-determined and used to evaluate the results. A numerical analysis also has the benefit of providing the response not only at a single receiving point but at any node in the model.

  5. Palm-Based Data Acquisition Solutions for the Undergraduate Chemistry Laboratory

    NASA Astrophysics Data System (ADS)

    Hudgins, Susan; Qin, Yu; Bakker, Eric; Shannon, Curtis

    2003-11-01

    Handheld computers provide a compact and cost-effective means to log data in the undergraduate chemistry laboratory. Handheld computers have the ability to record multiple forms of data, be programmed for specific projects, and later have data transferred to a personal computer for manipulation and analysis. They are more affordable than notebook computers and are more widely applicable than programmable calculators. This study focuses on acid base titration experiments that are commonly used in introductory chemistry courses. We wrote an interactive Basic language program that allowed a Palm device to measure pH during the course of a titration, and we used a compatible interface for the data acquisition, which we found to record accurate voltage measurements. After synchronizing the device to a laboratory workstation, the experimental data could be transferred into a spreadsheet file, viewed in graphical form and analyzed. Many other applications of handheld computers in the laboratory are possible with the ability to write individual programs on a handheld device. Therefore, the Palm's size, ease of use, and affordability make it an attractive alternative to previous data acquisition methods for use in the chemical laboratory.

  6. Advances in laboratory diagnosis of hereditary spherocytosis.

    PubMed

    Farias, Mariela Granero

    2016-11-12

    Among the red cell membrane disorders, hereditary spherocytosis (HS) is one of the most common causes of inherited hemolytic anemia. HS results from the deficiency or dysfunction of red blood cell membrane proteins, such as α spectrin, β spectrin, ankyrin, anion channel protein (Band-3 protein), protein 4.1 and protein 4.2. Conventionally, HS diagnosis is established through a series of tests, which include spherocytes identification in peripheral smear, reticulocyte count, osmotic fragility, etc. Currently, different hematological analyzers provide erythrocyte indicators that estimate the presence of spherocytes and correlate that with HS, which can be useful for disease screening. The most traditional method is the osmotic fragility (OF) test, which is labor-intensive and time-consuming to perform and presents low sensitivity and specificity values. Thus, new methods have been developed for HS diagnosis, such as flow cytometry. Current guidelines recommend the use of flow cytometry as a screening test for HS diagnosis using the eosin-5'-maleimide (EMA) binding test. Thus, HS diagnosis is the result of a collaboration between clinicians and laboratories, who should take into account the family history and the exclusion of other causes of secondary spherocytosis.

  7. Laboratory Techniques in Geology: Embedding Analytical Methods into the Undergraduate Curriculum

    NASA Astrophysics Data System (ADS)

    Baedke, S. J.; Johnson, E. A.; Kearns, L. E.; Mazza, S. E.; Gazel, E.

    2014-12-01

    Paid summer REU experiences successfully engage undergraduate students in research and encourage them to continue to graduate school and scientific careers. However these programs only accommodate a limited number of students due to funding constraints, faculty time commitments, and limited access to needed instrumentation. At JMU, the Department of Geology and Environmental Science has embedded undergraduate research into the curriculum. Each student fulfilling a BS in Geology or a BA in Earth Science completes 3 credits of research, including a 1-credit course on scientific communication, 2 credits of research or internship, followed by a presentation of that research. Our department has successfully acquired many analytical instruments and now has an XRD, SEM/EDS, FTIR, handheld Raman, AA, ion chromatograph, and an IRMS. To give as many students as possible an overview to the scientific uses and operation methods for these instruments, we revived a laboratory methods course that includes theory and practical use of instrumentation at JMU, plus XRF sample preparation and analysis training at Virginia Tech during a 1-day field trip. In addition to practical training, projects included analytical concepts such as evaluating analytical vs. natural uncertainty, determining error on multiple measurements, signal-to-noise ratio, and evaluating data quality. State funding through the 4-VA program helped pay for analytical supplies and support for students to complete research projects over the summer or during the next academic year using instrumentation from the course. This course exemplifies an alternative path to broadening participation in undergraduate research and creating stronger partnerships between PUI's and research universities.

  8. Technological advances in the hemostasis laboratory.

    PubMed

    Lippi, Giuseppe; Plebani, Mario; Favaloro, Emmanuel J

    2014-03-01

    Automation is conventionally defined as the use of machines, control systems, and information technologies to optimize productivity. Although automation is now commonplace in several areas of diagnostic testing, especially in clinical chemistry and immunochemistry, the concept of extending this process to hemostasis testing has only recently been advanced. The leading drawbacks are still represented by the almost unique biological matrix because citrated plasma can only be used for clotting assays and few other notable exceptions, and by the highly specific pretreatment of samples, which is particularly distinct to other test systems. Despite these important limitations, a certain degree of automation is also now embracing hemostasis testing. The more relevant developments include the growing integration of routine hemostasis analyzers with track line systems and workcells, the development of specific instrumentation tools to enhance reliability of testing (i.e., signal detection with different technologies to increase test panels, plasma indices for preanalytical check of interfering substances, failure patterns sensors for identifying insufficient volume, clots or bubbles, cap-piercing for enhancing operator safety, automatic reflex testing, automatic redilution of samples, and laser barcode readers), preanalytical features (e.g., positive identification, automatic systems for tube(s) labeling, transillumination devices), and postphlebotomy tools (pneumatic tube systems for reducing turnaround time, sample transport boxes for ensuring stability of specimens, monitoring systems for identifying unsuitable conditions of transport). Regardless of these important innovations, coagulation/hemostasis testing still requires specific technical and clinical expertise, not only in terms of measurement procedures but also for interpreting and then appropriately utilizing the derived information. Thus, additional and special caution has to be used when designing projects of

  9. [Recent advances in immunologic laboratory testing for rheumatic diseases].

    PubMed

    Akahoshi, Tohru

    2004-09-01

    Immunologic laboratory tests serve critical roles in the care of patients with various rheumatic diseases. These tests can provide relevant information of rheumatic diseases based on their immunopathophysiological condition. Although immunologic laboratory tests are quite useful for the determination of diagnosis and the estimation of disease activity, organ involvement and prognosis, they are frequently misused and resulted in an inappropriate diagnosis and treatment. Appropriate use of immunologic laboratory tests and accurate clinical interpretation of the test results can prevent false diagnosis and unnecessary treatment. In order to improve clinical care of patients with rheumatic diseases, clinicians caring patients with rheumatic disease should recognize meanings, characteristics and limitations of each result of immunologic laboratory testing. This article reviewed recent advances in immunologic laboratory testing such as antinuclear antibody, anti-DNA antibody and anti-neutrophil cytoplasmic antibody, and introduced guidelines for these testing. These guidelines based on evidences of EBM may contribute to the appropriate use of immunologic laboratory tests for rheumatic diseases.

  10. The Transect Program: Undergraduate Research at Sea and in the Laboratory

    NASA Astrophysics Data System (ADS)

    Sautter, L. R.; Sancho, G.

    2005-12-01

    Active participation in independent research that begins with data collection at sea has been shown to significantly increase undergraduate interest toward pursuing a career in ocean science. Thirty-five undergraduate students have recently enrolled in one of four NSF-sponsored Transect Programs at the College of Charleston. Each multi-disciplinary program consisted of an intensive 5-day research cruise, followed by a rigorous semester Oceanographic Research course in which students learned laboratory techniques for analyzing the biological, physical and geological samples collected. Students also conducted individual research, presented their results at both a poster and oral session, and prepared a manuscript following journal guidelines. Students showed significant comprehension of their research results and interest in continuing their research. Student applications to jobs, graduate schools, scholarships and internships have shown greater than 90% acceptance rate. The program's next phase will include expansion to numerous institutions in the southeast and elsewhere, coordinating with coastal and ocean observatory networks while training a new generation of oceanographers.

  11. Demand for interdisciplinary laboratories for physiology research by undergraduate students in biosciences and biomedical engineering.

    PubMed

    Clase, Kari L; Hein, Patrick W; Pelaez, Nancy J

    2008-12-01

    Physiology as a discipline is uniquely positioned to engage undergraduate students in interdisciplinary research in response to the 2006-2011 National Science Foundation Strategic Plan call for innovative transformational research, which emphasizes multidisciplinary projects. To prepare undergraduates for careers that cross disciplinary boundaries, students need to practice interdisciplinary communication in academic programs that connect students in diverse disciplines. This report surveys policy documents relevant to this emphasis on interdisciplinary training and suggests a changing role for physiology courses in bioscience and engineering programs. A role for a physiology course is increasingly recommended for engineering programs, but the study of physiology from an engineering perspective might differ from the study of physiology as a basic science. Indeed, physiology laboratory courses provide an arena where biomedical engineering and bioscience students can apply knowledge from both fields while cooperating in multidisciplinary teams under specified technical constraints. Because different problem-solving approaches are used by students of engineering and bioscience, instructional innovations are needed to break down stereotypes between the disciplines and create an educational environment where interdisciplinary teamwork is used to bridge differences.

  12. The Advanced Controls Program at Oak Ridge National Laboratory

    SciTech Connect

    Knee, H.E.; White, J.D.

    1990-01-01

    The Oak Ridge National Laboratory (ORNL), under sponsorship of the US Department of Energy (DOE), is conducting research that will lead to advanced, automated control of new liquid-metal-reactor (LMR) nuclear power plants. Although this program of research (entitled the Advanced Controls Program'') is focused on LMR technology, it will be capable of providing control design, test, and qualification capability for other advanced reactor designs (e.g., the advanced light water reactor (ALWR) and high temperature gas-cooled reactor (HTGR) designs), while also benefiting existing nuclear plants. The Program will also have applicability to complex, non-nuclear process control environments (e.g., petrochemical, aerospace, etc.). The Advanced Controls Program will support capabilities throughout the entire plant design life cycle, i.e., from the initial interactive first-principle dynamic model development for the process, systems, components, and instruments through advanced control room qualification. The current program involves five principal areas of research activities: (1) demonstrations of advanced control system designs, (2) development of an advanced controls design environment, (3) development of advanced control strategies, (4) research and development (R D) in human-system integration for advanced control system designs, and (5) testing and validation of advanced control system designs. Discussion of the research in these five areas forms the basis of this paper. Also included is a description of the research directions of the program. 8 refs.

  13. Mentoring for retention and advancement in the multigenerational clinical laboratory.

    PubMed

    Laudicina, R J

    2001-01-01

    Retention of recent graduates and other laboratory practitioners in the workplace will play a key role in addressing current and projected shortages of clinical laboratory scientists (CLS) and technicians (CLT). In addition, with overrepresentation of the aging Baby Boomer generation in laboratory supervisory and management positions, it is crucial not only to retain younger practitioners, but to prepare them for assuming these important functions in the future. Mentoring, a practice commonly employed in other professions, is widely considered to be useful in employee retention and career advancement. Mentoring has probably been used in the clinical laboratory profession, but has not been well documented. In the clinical laboratory environment, potential mentors are in the Veteran and Baby Boomer generations, and new practitioners who could benefit from mentoring are in Generation X. Generational differences among these groups may present challenges to the use of mentoring. This article will attempt to provide a better understanding of generational differences and show how mentoring can be applied in the setting of the clinical laboratory in order to increase retention and promote career advancement of younger practitioners. A panel of five laboratory managers provided examples of mentoring strategies. Definitions, benefits, and examples of mentoring are addressed in the accompanying article, "Passing the Torch: Mentoring the Next Generation of Laboratory Professionals".

  14. Structured inquiry-based learning: Drosophila GAL4 enhancer trap characterization in an undergraduate laboratory course.

    PubMed

    Dunne, Christopher R; Cillo, Anthony R; Glick, Danielle R; John, Katherine; Johnson, Cody; Kanwal, Jaspinder; Malik, Brian T; Mammano, Kristina; Petrovic, Stefan; Pfister, William; Rascoe, Alexander S; Schrom, Diane; Shapiro, Scott; Simkins, Jeffrey W; Strauss, David; Talai, Rene; Tomtishen, John P; Vargas, Josephine; Veloz, Tony; Vogler, Thomas O; Clenshaw, Michael E; Gordon-Hamm, Devin T; Lee, Kathryn L; Marin, Elizabeth C

    2014-12-01

    We have developed and tested two linked but separable structured inquiry exercises using a set of Drosophila melanogaster GAL4 enhancer trap strains for an upper-level undergraduate laboratory methods course at Bucknell University. In the first, students learn to perform inverse PCR to identify the genomic location of the GAL4 insertion, using FlyBase to identify flanking sequences and the primary literature to synthesize current knowledge regarding the nearest gene. In the second, we cross each GAL4 strain to a UAS-CD8-GFP reporter strain, and students perform whole mount CNS dissection, immunohistochemistry, confocal imaging, and analysis of developmental expression patterns. We have found these exercises to be very effective in teaching the uses and limitations of PCR and antibody-based techniques as well as critical reading of the primary literature and scientific writing. Students appreciate the opportunity to apply what they learn by generating novel data of use to the wider research community.

  15. Design and Construction of a Two-Temperature Preference Behavioral Assay for Undergraduate Neuroscience Laboratories

    PubMed Central

    Daniels, Richard L.; McKemy, David D.

    2010-01-01

    Behavioral assays in the undergraduate neuroscience laboratory are useful for illustrating a variety of physiological concepts. An example is homeostatic temperature regulation (thermoregulation). Many model organisms, from flies to mice, regulate internal temperatures in part by moving to suitable climates (thermotaxis). A particularly reliable method of quantifying temperature-dependent thermotactic behaviors is the two-temperature preference behavioral assay. In this preparation, an organism is free to move between two temperature-controlled surfaces, thus revealing its preferred thermal environment. Here we present the design and construction of a two-temperature preference assay chamber. The device uses Peltier-based thermoelectric modules (TECs) for heating and cooling, and is capable of precision control of temperatures from −5ºC to 60ºC. Our approach can be easily adapted for use in a variety of physiological and behavioral assays that require precise temperature control over a wide range of temperatures. PMID:23494724

  16. A Study of Concept Mapping as an Instructional Intervention in an Undergraduate General Chemistry Calorimetry Laboratory

    NASA Astrophysics Data System (ADS)

    Stroud, Mary W.

    This investigation, rooted in both chemistry and education, considers outcomes occurring in a small-scale study in which concept mapping was used as an instructional intervention in an undergraduate calorimetry laboratory. A quasi-experimental, multiple-methods approach was employed since the research questions posed in this study warranted the use of both qualitative and quantitative perspectives and evaluations. For the intervention group of students, a convenience sample, post-lab concept maps, written discussions, quiz responses and learning surveys were characterized and evaluated. Archived quiz responses for non-intervention students were also analyzed for comparison. Students uniquely constructed individual concept maps containing incorrect, conceptually correct and "scientifically thin" calorimetry characterizations. Students more greatly emphasized mathematical relationships and equations utilized during the calorimetry experiment; the meaning of calorimetry concepts was demonstrated to a lesser extent.

  17. Purification and characterization of enzymes from yeast: an extended undergraduate laboratory sequence for large classes.

    PubMed

    Johanson, Kelly E; Watt, Terry J; McIntyre, Neil R; Thompson, Marleesa

    2013-01-01

    Providing a project-based experience in an undergraduate biochemistry laboratory class can be complex with large class sizes and limited resources. We have designed a 6-week curriculum during which students purify and characterize the enzymes invertase and phosphatase from bakers yeast. Purification is performed in two stages via ethanol precipitation and anion exchange chromatography, and students perform both direct and coupled enzyme assays. By completion of the experimental series, students are able to identify which enzymes they have purified and have obtained kinetic parameters for one. This experimental series requires minimal instructor preparation time, is cost effective, and works with multiple sections of large groups of students. Students participating in this sequence showed increases in conceptual understanding of biochemical concepts as measured through in-class assessments and anonymous surveys.

  18. A basic Michelson laser interferometer for the undergraduate teaching laboratory demonstrating picometer sensitivity

    NASA Astrophysics Data System (ADS)

    Libbrecht, Kenneth G.; Black, Eric D.

    2015-05-01

    We describe a basic Michelson laser interferometer experiment for the undergraduate teaching laboratory that achieves picometer sensitivity in a hands-on, table-top instrument. In addition to providing an introduction to interferometer physics and optical hardware, the experiment also focuses on precision measurement techniques including servo control, signal modulation, phase-sensitive detection, and different types of signal averaging. Students examine these techniques in a series of steps that take them from micron-scale sensitivity using direct fringe counting to picometer sensitivity using a modulated signal and phase-sensitive signal averaging. After students assemble, align, and characterize the interferometer, they then use it to measure nanoscale motions of a simple harmonic oscillator system as a substantive example of how laser interferometry can be used as an effective tool in experimental science.

  19. Advanced Propulsion Concepts at the Jet Propulsion Laboratory

    NASA Technical Reports Server (NTRS)

    Brophy, J. R.

    1997-01-01

    Current interest in advanced propulsion within NASA and research activities in advanced propulsion concepts at the Jet Propulsion Laboratory are reviewed. The concepts, which include high power plasma thrusters such as lithuim-fueled Lorentz-Force-Accelerators, MEMS-scale propulsion systems, in-situ propellant utilization techniques, fusion propulsion systems and methods of using antimatter, offer the potential for either significantly enhancing space transportation capability as compared with that of traditional chemical propulsion, or enabling ambitious new missions.

  20. Towards the Standardization of a MATLAB-Based Control Systems Laboratory Experience for Undergraduate Students

    SciTech Connect

    Dixon, W.E.

    2001-03-15

    This paper seeks to begin a discussion with regard to developing standardized Computer Aided Control System Design (CACSD) tools that are typically utilized in an undergraduate controls laboratory. The advocated CACSD design tools are based on the popular, commercially available MATLAB environment, the Simulink toolbox, and the Real-Time Workshop toolbox. The primary advantages of the proposed approach are as follows: (1) the required computer hardware is low cost, (2) commercially available plants from different manufacturers can be supported under the same CACSD environment with no hardware modifications, (3) both the Windows and Linux operating systems can be supported via the MATLAB based Real-Time Windows Target and the Quality Real Time Systems (QRTS) based Real-Time Linux Target, and (4) the Simulink block diagram approach can be utilized to prototype control strategies; thereby, eliminating the need for low level programming skills. It is believed that the above advantages related to standardization of the CACSD design tools will facilitate: (1) the sharing of laboratory resources within each university (i.e., between departments) and (2) the development of Internet laboratory experiences for students (i.e., between universities).

  1. Cross-disciplinary thermoregulation and sweat analysis laboratory experiences for undergraduate Chemistry and Exercise Science students.

    PubMed

    Mulligan, Gregory; Taylor, Nichole; Glen, Mary; Tomlin, Dona; Gaul, Catherine A

    2011-06-01

    Cross-disciplinary (CD) learning experiences benefit student understanding of concepts and curriculum by offering opportunities to explore topics from the perspectives of alternate fields of study. This report involves a qualitative evaluation of CD health sciences undergraduate laboratory experiences in which concepts and students from two distinct disciplines [chemistry (CHEM) and exercise physiology (EPHE)] combined to study exercise thermoregulation and sweat analysis. Twenty-eight senior BSc Kinesiology (EPHE) students and 42 senior BSc CHEM students participated as part of their mutually exclusive, respective courses. The effectiveness of this laboratory environment was evaluated qualitatively using written comments collected from all students as well as from formal focus groups conducted after the CD laboratory with a representative cohort from each class (n = 16 CHEM students and 9 EPHE students). An open coding strategy was used to analyze the data from written feedback and focus group transcripts. Coding topics were generated and used to develop five themes found to be consistent for both groups of students. These themes reflected the common student perceptions that the CD experience was valuable and that students enjoyed being able to apply academic concepts to practical situations as well as the opportunity to interact with students from another discipline of study. However, students also reported some challenges throughout this experience that stemmed from the combination of laboratory groups from different disciplines with limited modification to the design of the original, pre-CD, learning environments. The results indicate that this laboratory created an effective learning opportunity that fostered student interest and enthusiasm for learning. The findings also provide information that could inform subsequent design and implementation of similar CD experiences to enhance engagement of all students and improve instructor efficacy.

  2. Strategies for Advancing Women in Physics and other Sciences in an Undergraduate Hispanic Institution (abstract)

    NASA Astrophysics Data System (ADS)

    Ramos, Idalia

    2009-04-01

    For the past 15 years, University of Puerto Rico at Humacao (UPRH) has implemented various efforts to increase participation and promote advancement of women in physics and other sciences. The strategies used include mentoring, collaborating, forming women's organizations, and offering training workshops. The physics program at UPRH is the largest in Puerto Rico with approximately 95 undergraduates. Since 1995, female students in the program have increased from 17% to 32%. Efforts to integrate women in undergraduate research as early as possible in their studies show promising results, with the percentage of women in research increasing from 13% to 60% in the last 13 years. The Faculty in Training (FIT) program, begun in 2003, has supported talented women students interested in academic careers. The first FIT physics student will obtain her PhD in 2009. At the faculty level, UPRH received a first-round US National Science Foundation ADVANCE Institutional Transformation Award in 2001. The ADVANCE legacy at UPRH is evident at levels ranging from changes in individual behaviors to the adoption of institutional policies. A strong network of women in science and their supporters continues to advance this legacy.

  3. Advances in Measurement Technology at NIST's Physical Measurement Laboratory

    NASA Astrophysics Data System (ADS)

    Dehmer, Joseph

    2014-03-01

    The NIST mission is to promote U.S. innovation and industrial competitiveness by advancing measurement science, standards, and technology. The Physical Measurement Laboratory (PML) has responsibility for maintaining national standards for two dozen physical quantities needed for international trade; and, importantly, it carries out advanced research at the frontiers of measurement science to enable extending innovation into new realms and new markets. This talk will highlight advances being made across several sectors of technology; and it will describe how PML interacts with its many collaborators and clients in industry, government, and academe.

  4. Isolation and Culture of Bovine Oviductal Epithelial Cells for Use in the Anatomy and Physiology Laboratory and Undergraduate Research

    ERIC Educational Resources Information Center

    Way, Amy L.

    2006-01-01

    This article presents methods for the isolation and culture of epithelial cells from the bovine oviduct for use in both research and the teaching laboratory and provides examples of ways that an oviductal cell culture can be incorporated into an undergraduate research program. Cow reproductive tracts are readily available from area butchers, and…

  5. Oxidation of Borneol to Camphor Using Oxone and Catalytic Sodium Chloride: A Green Experiment for the Undergraduate Organic Chemistry Laboratory

    ERIC Educational Resources Information Center

    Lang, Patrick T.; Harned, Andrew M.; Wissinger, Jane E.

    2011-01-01

    A new green oxidation procedure was developed for the undergraduate organic teaching laboratories using Oxone and a catalytic quantity of sodium chloride for the conversion of borneol to camphor. This simple 1 h, room temperature reaction afforded high quality and yield of product, was environmentally friendly, and produced negligible quantities…

  6. Red Seaweed Enzyme-Catalyzed Bromination of Bromophenol Red: An Inquiry-Based Kinetics Laboratory Experiment for Undergraduates

    ERIC Educational Resources Information Center

    Jittam, Piyachat; Boonsiri, Patcharee; Promptmas, Chamras; Sriwattanarothai, Namkang; Archavarungson, Nattinee; Ruenwongsa, Pintip; Panijpan, Bhinyo

    2009-01-01

    Haloperoxidase enzymes are of interest for basic and applied bioscientists because of their increasing importance in pharmaceutical industry and environmental cleanups. In a guided inquiry-based laboratory experiment for life-science, agricultural science, and health science undergraduates, the bromoperoxidase from a red seaweed was used to…

  7. The Determination of Vitamin D-Dependent Calcium Binding Protein in Chick Intesting: An Undergraduate Biochemistry Laboratory Experiment.

    ERIC Educational Resources Information Center

    Lessard, George M.

    1980-01-01

    Described is an experiment used in an undergraduate biochemistry laboratory involving inducing rickets in chicks and correlating the disease to a reduction in vitamin D-dependent calcium binding protein. Techniques involved are hormone induction, protein isolation, and radioisotope methodology. (Author/DS)

  8. SIPCAn (Separation, Isolation, Purification, Characterization, and Analysis): A One-Term, Integrated Project for the Undergraduate Organic Laboratory

    ERIC Educational Resources Information Center

    Dintzner, Matthew R.; Kinzie, Charles R.; Pulkrabek, Kimberly A.; Arena, Anthony F.

    2011-01-01

    SIPCAn, an acronym for separation, isolation, purification, characterization, and analysis, is presented as a one-term, integrated project for the first-term undergraduate organic laboratory course. Students are assigned two mixtures of unknown organic compounds--a mixture of two liquid compounds and a mixture of two solid compounds--at the…

  9. Acid-Catalyzed Preparation of Biodiesel from Waste Vegetable Oil: An Experiment for the Undergraduate Organic Chemistry Laboratory

    ERIC Educational Resources Information Center

    Bladt, Don; Murray, Steve; Gitch, Brittany; Trout, Haylee; Liberko, Charles

    2011-01-01

    This undergraduate organic laboratory exercise involves the sulfuric acid-catalyzed conversion of waste vegetable oil into biodiesel. The acid-catalyzed method, although inherently slower than the base-catalyzed methods, does not suffer from the loss of product or the creation of emulsion producing soap that plagues the base-catalyzed methods when…

  10. Kinetics of Hydrolysis of Acetic Anhydride by In-Situ FTIR Spectroscopy: An Experiment for the Undergraduate Laboratory

    ERIC Educational Resources Information Center

    Haji, Shaker; Erkey, Can

    2005-01-01

    A reaction kinetics experiment for the chemical engineering undergraduate laboratory course was developed in which in-situ Fourier Transfer Infrared spectroscopy was used to measure reactant and product concentrations. The kinetics of the hydrolysis of acetic anhydride was determined by experiments carried out in a batch reactor. The results…

  11. The Cyclohexanol Cycle and Synthesis of Nylon 6,6: Green Chemistry in the Undergraduate Organic Laboratory

    ERIC Educational Resources Information Center

    Dintzner, Matthew R.; Kinzie, Charles R.; Pulkrabek, Kimberly; Arena, Anthony F.

    2012-01-01

    A one-term synthesis project that incorporates many of the principles of green chemistry is presented for the undergraduate organic laboratory. In this multistep scheme of reactions, students react, recycle, and ultimately convert cyclohexanol to nylon 6,6. The individual reactions in the project employ environmentally friendly methodologies, and…

  12. COED Transactions, Vol. XI, No. 12, December 1979. Some Alternate Applications of Microprocessor Trainers in Support of Undergraduate Laboratories.

    ERIC Educational Resources Information Center

    Mitchell, Eugene E., Ed.

    Ways are described for the use of a microprocessor trainer in undergraduate laboratories. Listed are microcomputer applications that have been used as demonstrations and which provide signals for other experiments which are not related to microprocessors. Information and figures are provided for methods to do the following: direct generation of…

  13. Synthesis of 10-Ethyl Flavin: A Multistep Synthesis Organic Chemistry Laboratory Experiment for Upper-Division Undergraduate Students

    ERIC Educational Resources Information Center

    Sichula, Vincent A.

    2015-01-01

    A multistep synthesis of 10-ethyl flavin was developed as an organic chemistry laboratory experiment for upper-division undergraduate students. Students synthesize 10-ethyl flavin as a bright yellow solid via a five-step sequence. The experiment introduces students to various hands-on experimental organic synthetic techniques, such as column…

  14. Fitting It All In: Adapting a Green Chemistry Extraction Experiment for Inclusion in an Undergraduate Analytical Laboratory

    ERIC Educational Resources Information Center

    Buckley, Heather L.; Beck, Annelise R.; Mulvihill, Martin J.; Douskey, Michelle C.

    2013-01-01

    Several principles of green chemistry are introduced through this experiment designed for use in the undergraduate analytical chemistry laboratory. An established experiment of liquid CO2 extraction of D-limonene has been adapted to include a quantitative analysis by gas chromatography. This facilitates drop-in incorporation of an exciting…

  15. Validating the Goldstein-Wehner Law for the Stratified Positive Column of DC Discharge in an Undergraduate Laboratory

    ERIC Educational Resources Information Center

    Lisovskiy, V. A.; Koval, V. A.; Artushenko, E. P.; Yegorenkov, V. D.

    2012-01-01

    In this paper we suggest a simple technique for validating the Goldstein-Wehner law for a stratified positive column of dc glow discharge while studying the properties of gas discharges in an undergraduate laboratory. To accomplish this a simple device with a pre-vacuum mechanical pump, dc source and gas pressure gauge is required. Experiments may…

  16. Enhancing Hispanic Minority Undergraduates' Botany Laboratory Experiences: Implementation of an Inquiry-Based Plant Tissue Culture Module Exercise

    ERIC Educational Resources Information Center

    Siritunga, Dimuth; Navas, Vivian; Diffoot, Nanette

    2012-01-01

    Early involvement of students in hands-on research experiences are known to demystify research and promote the pursuit of careers in science. But in large enrollment departments such opportunities for undergraduates to participate in research are rare. To counteract such lack of opportunities, inquiry-based laboratory module in plant tissue…

  17. Ab Initio Determinations of Photoelectron Spectra Including Vibronic Features: An Upper-Level Undergraduate Physical Chemistry Laboratory

    ERIC Educational Resources Information Center

    Lord, Richard L.; Davis, Lisa; Millam, Evan L.; Brown, Eric; Offerman, Chad; Wray, Paul; Green, Susan M. E.

    2008-01-01

    We present a first-principles determination of the photoelectron spectra of water and hypochlorous acid as a laboratory exercise accessible to students in an undergraduate physical chemistry course. This paper demonstrates the robustness and user-friendliness of software developed for the Franck-Condon factor calculation. While the calculator is…

  18. Gold Electrodes Modified with Self-Assembled Monolayers for Measuring L-Ascorbic Acid: An Undergraduate Analytical Chemistry Laboratory Experiment

    ERIC Educational Resources Information Center

    Ito, Takashi; Perera, D. M. Neluni T.; Nagasaka, Shinobu

    2008-01-01

    This article describes an undergraduate electrochemistry laboratory experiment in which the students measure the L-ascorbic acid content of a real sample. Gold electrodes modified with self-assembled monolayers (SAMs) of thioctic acid and cysteamine are prepared to study the effects of surface modification on the electrode reaction of L-ascorbic…

  19. HPLC of the Polypeptides in a Hydrolyzate of Egg-White Lysozyme. An Experiment for the Undergraduate Biochemistry Laboratory.

    ERIC Educational Resources Information Center

    Richardson, W. S., III; Burns, L.

    1988-01-01

    Describes a simple high-performance liquid chromatography experiment for undergraduate biochemistry laboratories. The experiment illustrates the separation of polypeptides by a step gradient elution using a single pump instrument with no gradient attachments. Discusses instrumentation, analysis, a sample preparation, and results. (CW)

  20. The Biochemistry of the Muscle Contraction Process: An Undergraduate Laboratory Experiment Using Viscosity to Follow the Progress of a Reaction.

    ERIC Educational Resources Information Center

    Belliveau, James F.; And Others

    1981-01-01

    Describes an undergraduate laboratory experiment using viscosity to follow the progress of the contractile process in muscles. This simple, short experiment illustrates the action of ATP as the source of energy in the contractile process and the catalytic effect of calcium ions as a control in the energy producing process. (CS)

  1. Nickel-Catalyzed Suzuki-Miyaura Cross-Coupling in a Green Alcohol Solvent for an Undergraduate Organic Chemistry Laboratory

    ERIC Educational Resources Information Center

    Hie, Liana; Chang, Jonah J.; Garg, Neil K.

    2015-01-01

    A modern undergraduate organic chemistry laboratory experiment involving the Suzuki-Miyaura coupling is reported. Although Suzuki-Miyaura couplings typically employ palladium catalysts in environmentally harmful solvents, this experiment features the use of inexpensive nickel catalysis, in addition to a "green" alcohol solvent. The…

  2. Polybrominated Diphenyl Ethers in Dryer Lint: An Advanced Analysis Laboratory

    ERIC Educational Resources Information Center

    Thompson, Robert Q.

    2008-01-01

    An advanced analytical chemistry laboratory experiment is described that involves environmental analysis and gas chromatography-mass spectrometry. Students analyze lint from clothes dryers for traces of flame retardant chemicals, polybrominated diphenylethers (PBDEs), compounds receiving much attention recently. In a typical experiment, ng/g…

  3. Results of Laboratory Testing of Advanced Power Strips

    SciTech Connect

    Earle, L.; Sparn, B.

    2012-08-01

    Presented at the ACEEE Summer Study on Energy Efficiency in Buildings on August 12-17, 2012, this presentation reports on laboratory tests of 20 currently available advanced power strip products, which reduce wasteful electricity use of miscellaneous electric loads in buildings.

  4. A Simultaneous Analysis Problem for Advanced General Chemistry Laboratories.

    ERIC Educational Resources Information Center

    Leary, J. J.; Gallaher, T. N.

    1983-01-01

    Oxidation of magnesium metal in air has been used as an introductory experiment for determining the formula of a compound. The experiment described employs essentially the same laboratory procedure but is significantly more advanced in terms of information sought. Procedures and sample calculations/results are provided. (JN)

  5. A Reverse Osmosis System for an Advanced Separation Process Laboratory.

    ERIC Educational Resources Information Center

    Slater, C. S.; Paccione, J. D.

    1987-01-01

    Focuses on the development of a pilot unit for use in an advanced separations process laboratory in an effort to develop experiments on such processes as reverse osmosis, ultrafiltration, adsorption, and chromatography. Discusses reverse osmosis principles, the experimental system design, and some experimental studies. (TW)

  6. Using Field Trips and Field-Based Laboratories to Teach Undergraduate Soil Science

    NASA Astrophysics Data System (ADS)

    Brevik, Eric C.; Steffan, Joshua; Hopkins, David

    2015-04-01

    Classroom activities can provide important background information allowing students to understand soils. However, soils are formed in nature; therefore, understanding their properties and spatial relationships in the field is a critical component for gaining a comprehensive and holistic understanding of soils. Field trips and field-based laboratories provide students with the field experiences and skills needed to gain this understanding. Field studies can 1) teach students the fundamentals of soil descriptions, 2) expose students to features (e.g., structure, redoximorphic features, clay accumulation, etc.) discussed in the classroom, and 3) allow students to verify for themselves concepts discussed in the more theoretical setting of the classroom. In each case, actually observing these aspects of soils in the field reinforces and improves upon classroom learning and comprehension. In addition, the United States Department of Agriculture's Natural Resources Conservation Service has identified a lack of fundamental field skills as a problem when they hire recent soil science graduates, thereby demonstrating the need for increased field experiences for the modern soil science student. In this presentation we will provide examples of field trips and field-based laboratories that we have designed for our undergraduate soil science classes, discuss the learning objectives, and provide several examples of comments our students have made in response to these field experiences.

  7. Illuminating the Undergraduate Behavioral Neuroscience Laboratory: A Guide for the in vivo Application of Optogenetics in Mammalian Model Organisms.

    PubMed

    Roberts, Bradley M; Jarrin, Sarah E; Mathur, Brian N; Bailey, Aileen M

    2016-01-01

    Optogenetics is a technology that is growing rapidly in neuroscience, establishing itself as a fundamental investigative tool. As this tool is increasingly utilized across the neuroscience community and is one of the primary research techniques being presented at neuroscience conferences and in journals, we believe that it is important that this technology is introduced into the undergraduate neuroscience research laboratory. While there has been a significant body of work concentrated to deploy optogenetics in invertebrate model organisms, little to no work has focused on brining this technology to mammalian model organisms in undergraduate neuroscience laboratories. The establishment of in vivo optogenetics could provide for high-impact independent research projects for upper-level undergraduate students. Here we review the considerations for establishing in vivo optogenetics with the use of rodents in an undergraduate laboratory setting and provide some cost-saving guidelines to assist in making optogenetic technologies financially accessible. We discuss opsin selection, cell-specific opsin expression strategies, species selection, experimental design, selection of light delivery systems, and the construction of implantable optical fibers for the application of in vivo optogenetics in rodents.

  8. Illuminating the Undergraduate Behavioral Neuroscience Laboratory: A Guide for the in vivo Application of Optogenetics in Mammalian Model Organisms

    PubMed Central

    Roberts, Bradley M.; Jarrin, Sarah E.; Mathur, Brian N.; Bailey, Aileen M.

    2016-01-01

    Optogenetics is a technology that is growing rapidly in neuroscience, establishing itself as a fundamental investigative tool. As this tool is increasingly utilized across the neuroscience community and is one of the primary research techniques being presented at neuroscience conferences and in journals, we believe that it is important that this technology is introduced into the undergraduate neuroscience research laboratory. While there has been a significant body of work concentrated to deploy optogenetics in invertebrate model organisms, little to no work has focused on brining this technology to mammalian model organisms in undergraduate neuroscience laboratories. The establishment of in vivo optogenetics could provide for high-impact independent research projects for upper-level undergraduate students. Here we review the considerations for establishing in vivo optogenetics with the use of rodents in an undergraduate laboratory setting and provide some cost-saving guidelines to assist in making optogenetic technologies financially accessible. We discuss opsin selection, cell-specific opsin expression strategies, species selection, experimental design, selection of light delivery systems, and the construction of implantable optical fibers for the application of in vivo optogenetics in rodents. PMID:27385919

  9. Insights for undergraduates seeking an advanced degree in wildlife and fisheries sciences

    USGS Publications Warehouse

    Kaemingk, Mark A.; Dembkowski, Daniel J.; Meyer, Hilary A.; Gigliotti, Larry M.

    2013-01-01

    In today's job market, having a successful career in the fisheries and wildlife sciences is becoming more dependent on obtaining an advanced degree. As a result, competition for getting accepted into a graduate program is fierce. Our objective for this study was to provide prospective graduate students some insights as to what qualifications or attributes would best prepare them for obtaining a graduate position (M.S.) and to excel once they are enrolled in a graduate program. A survey was sent to 50 universities within the National Association of University Fisheries and Wildlife Programs (NAUFWP) where both faculty and undergraduate students were asked questions relating to graduate school. Faculty rated the importance of various criteria and attributes of graduate school, and students answered the questions according to how they believed faculty members would respond. Overall, undergraduate students shared many of the same graduate school viewpoints as those held by faculty members. However, viewpoints differed on some topics related to admittance and the most important accomplishment of a graduate student while enrolled in a graduate program. These results indicate that undergraduate students may be better prepared for graduate school—and they may understand how to be successful once they are enrolled in a program—than was initially thought.

  10. Nickel-Catalyzed Suzuki–Miyaura Cross-Coupling in a Green Alcohol Solvent for an Undergraduate Organic Chemistry Laboratory

    PubMed Central

    2015-01-01

    A modern undergraduate organic chemistry laboratory experiment involving the Suzuki–Miyaura coupling is reported. Although Suzuki–Miyaura couplings typically employ palladium catalysts in environmentally harmful solvents, this experiment features the use of inexpensive nickel catalysis, in addition to a “green” alcohol solvent. The experiment employs heterocyclic substrates, which are important pharmaceutical building blocks. Thus, this laboratory procedure exposes students to a variety of contemporary topics in organic chemistry, including transition metal-catalyzed cross-couplings, green chemistry, and the importance of heterocycles in drug discovery, none of which are well represented in typical undergraduate organic chemistry curricula. The experimental protocol uses commercially available reagents and is useful in both organic and inorganic instructional laboratories. PMID:25774064

  11. Nickel-Catalyzed Suzuki-Miyaura Cross-Coupling in a Green Alcohol Solvent for an Undergraduate Organic Chemistry Laboratory.

    PubMed

    Hie, Liana; Chang, Jonah J; Garg, Neil K

    2015-03-10

    A modern undergraduate organic chemistry laboratory experiment involving the Suzuki-Miyaura coupling is reported. Although Suzuki-Miyaura couplings typically employ palladium catalysts in environmentally harmful solvents, this experiment features the use of inexpensive nickel catalysis, in addition to a "green" alcohol solvent. The experiment employs heterocyclic substrates, which are important pharmaceutical building blocks. Thus, this laboratory procedure exposes students to a variety of contemporary topics in organic chemistry, including transition metal-catalyzed cross-couplings, green chemistry, and the importance of heterocycles in drug discovery, none of which are well represented in typical undergraduate organic chemistry curricula. The experimental protocol uses commercially available reagents and is useful in both organic and inorganic instructional laboratories.

  12. Laboratory Demonstrations for PDE and Metals Combustion at NASA MSFC's Advanced Propulsion Laboratory

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Report provides status reporting on activities under order no. H-30549 for the period December 1 through December 31, 1999. Details the activities of the contract in the coordination of planned conduct of experiments at the MSFC Advanced Propulsion Laboratory in pulse detonation MHD power production and metals combustion.

  13. Performance evaluation of the Oak Ridge National Laboratory's advanced servomanipulator

    SciTech Connect

    Draper, J.V.; Schrock, S.L.; Handel, S.J.

    1988-01-01

    The Consolidated Fuel Reprocessing Program (CFRP) at the Oak Ridge National Laboratory (ORNL) is developing technology for future nuclear fuel reprocessing facilities. This responsibility includes developing advanced telerobotic systems for repair and maintenance of such facilities. In response to a requirement for a highly reliable, remotely maintainable manipulator system, CFRP designed and built the advanced servomanipulator (ASM). This paper reports results of a recent comparison of ASM's performance to that of another highly dexterous manipulator, the Sargeant Industries/Central Research Laboratory's (CRL's) model M-2. Operators using ASM were able to complete tasks in about the same amount of time required to complete tasks with the CRL M-2. 13 refs., 5 figs., 2 tabs.

  14. Safety in the Chemical Laboratory: Safety in Academic Departments with Graduate and Undergraduate Programs.

    ERIC Educational Resources Information Center

    Landgrebe, John A.

    1985-01-01

    Describes the University of Kansas chemistry department's safety program. Comprehensive regulation, undergraduate regulations, safety equipment, handling accidents, inspections, and training are addressed. (JN)

  15. Adsorption laboratory experiment for undergraduate chemical engineering: Introducing kinetic, equilibrium and thermodynamic concepts

    NASA Astrophysics Data System (ADS)

    Muryanto, S.; Djatmiko Hadi, S.

    2016-11-01

    Adsorption laboratory experiment for undergraduate chemical engineering program is discussed. The experiment demonstrated adsorption of copper ions commonly found in wastewater using bio-sorbent, i.e. agricultural wastes. The adsorption was performed in a batch mode under various parameters: adsorption time (up to 120 min), initial pH (2 to 6), adsorbent dose (2.0 to 12.0 g L-1), adsorbent size (50 to 170 mesh), initial Cu2+ concentration (25 to 100 ppm) and temperatures (room temp to 40°C). The equilibrium and kinetic data of the experiments were calculated using the two commonly used isotherms: Langmuir and Lagergren pseudo-first-order kinetics. The maximum adsorption capacity for Cu2+ was found as 94.34 mg g-1. Thermodynamically, the adsorption process was spontaneous and endothermic. The calculated activation energy for the adsorption was observed as high as 127.94 kJ mol-1. Pedagogically, the experiment was assumed to be important in increasing student understanding of kinetic, equilibrium and thermodynamic concepts.

  16. Applying Statistics in the Undergraduate Chemistry Laboratory: Experiments with Food Dyes

    NASA Astrophysics Data System (ADS)

    Thomasson, Kathryn A.; Lofthus-Herschman, Sheila; Humbert, Michelle; Kulevsky, Norman

    1998-02-01

    Simple experiments have been developed using visible spectroscopy to introduce students to statistical analysis of data. Students in chemistry often gain their first substantial experience with statistics in undergraduate chemistry laboratories (Quantitative Analysis and Physical Chemistry). Simple experiments using Beer's Law of absorption spectroscopy help introduce students to applying statistics. We have chosen two food coloring dyes found in many household items: FD and C Red #40 and FD and C Blue #1. To learn to evaluate their data, the students determine the concentration of a solution at a variety of confidence limits, and treat their data for suspicious values using the Q-test. Other experiments can be done to learn the concept of pooled variance. For example, students compare solutions they make themselves to determine if they are the same to what confidence level. Furthermore, Beer's Law can be used to teach linear least squares fitting by using a serial dilution of a colored compound and measuring absorbance for each concentration. Finally, by using common household substances and a simple analysis technique, students find that statistics can be considerably less threatening, and in some cases even fun.

  17. Advanced Manufacturing Processes Laboratory Building 878 hazards assessment document

    SciTech Connect

    Wood, C.; Thornton, W.; Swihart, A.; Gilman, T.

    1994-07-01

    The introduction of the hazards assessment process is to document the impact of the release of hazards at the Advanced Manufacturing Processes Laboratory (AMPL) that are significant enough to warrant consideration in Sandia National Laboratories` operational emergency management program. This hazards assessment is prepared in accordance with the Department of Energy Order 5500.3A requirement that facility-specific hazards assessments be prepared, maintained, and used for emergency planning purposes. This hazards assessment provides an analysis of the potential airborne release of chemicals associated with the operations and processes at the AMPL. This research and development laboratory develops advanced manufacturing technologies, practices, and unique equipment and provides the fabrication of prototype hardware to meet the needs of Sandia National Laboratories, Albuquerque, New Mexico (SNL/NM). The focus of the hazards assessment is the airborne release of materials because this requires the most rapid, coordinated emergency response on the part of the AMPL, SNL/NM, collocated facilities, and surrounding jurisdiction to protect workers, the public, and the environment.

  18. Faculty perspectives of the undergraduate laboratory: A survey of faculty goals for the laboratory and comparative analysis of responses using statistical techniques

    NASA Astrophysics Data System (ADS)

    Bruck, Aaron D.

    Qualitative research methods were used in a previous study to discover the goals of faculty members teaching undergraduate laboratories. Assertions about the goals and the unique characteristics of innovative lab programs were developed from categories that emerged from the interviews. The purpose of the present research was to create a survey instrument to measure the prevalence of these themes and faculty goals for undergraduate laboratories with a national sample. This was achieved through a two-stage process that utilized a pilot survey to determine the factor structure and reduce the number of survey items to a manageable size. Once the number of survey questions was reduced, the full survey was given to a national sample of undergraduate laboratory faculty. The 312 responses to the survey were then analyzed using factor analysis. Comparative analyses were conducted using analysis of variance (ANOVA). This dissertation focuses on the processes involved in the creation of this survey and the subsequent analyses of the data the survey produced. The results of these analyses and the implications of this research will also be discussed.

  19. Apoptosis: A Four-Week Laboratory Investigation for Advanced Molecular and Cellular Biology Students

    PubMed Central

    DiBartolomeis, Susan M.; Moné, James P.

    2003-01-01

    Over the past decade, apoptosis has emerged as an important field of study central to ongoing research in many diverse fields, from developmental biology to cancer research. Apoptosis proceeds by a highly coordinated series of events that includes enzyme activation, DNA fragmentation, and alterations in plasma membrane permeability. The detection of each of these phenotypic changes is accessible to advanced undergraduate cell and molecular biology students. We describe a 4-week laboratory sequence that integrates cell culture, fluorescence microscopy, DNA isolation and analysis, and western blotting (immunoblotting) to follow apoptosis in cultured human cells. Students working in teams chemically induce apoptosis, and harvest, process, and analyze cells, using their data to determine the order of events during apoptosis. We, as instructors, expose the students to an environment closely simulating what they would encounter in an active cell or molecular biology research laboratory by having students coordinate and perform multiple tasks simultaneously and by having them experience experimental design using current literature, data interpretation, and analysis to answer a single question. Students are assessed by examination of laboratory notebooks for completeness of experimental protocols and analysis of results and for completion of an assignment that includes questions pertaining to data interpretation and apoptosis. PMID:14673493

  20. Demand for Interdisciplinary Laboratories for Physiology Research by Undergraduate Students in Biosciences and Biomedical Engineering

    ERIC Educational Resources Information Center

    Clase, Kari L.; Hein, Patrick W.; Pelaez, Nancy J.

    2008-01-01

    Physiology as a discipline is uniquely positioned to engage undergraduate students in interdisciplinary research in response to the 2006-2011 National Science Foundation Strategic Plan call for innovative transformational research, which emphasizes multidisciplinary projects. To prepare undergraduates for careers that cross disciplinary…

  1. Synthesis and Kinetics of Hydrolysis of 3,5-Dimethyl-N-acetyl-p-benzoquinone Imine: An Undergraduate Laboratory

    NASA Astrophysics Data System (ADS)

    Buccigross, Jeanne M.; Metz, Christa; Elliot, Lori; Becker, Pamela; Earley, Angela S.; Hayes, Jerry W.; Novak, Michael; Underwood, Gayl A.

    1996-04-01

    The synthesis of the title compound by a three-step procedure is described. The hydrolysis kinetics, which involve two consecutive psuedo-first-order processes, are also described. The synthesis and kinetics experiments described here are proposed for incorporation into undergraduate laboratory courses under a variety of formats. The compound described here is related to a toxic metabolite of the common analgesics acetaminophen and phenacetin.

  2. Two Successful Outreach Programs at Storm Peak Laboratory: GRASP for Undergraduates and Partnership for 5th Grade Science Education

    NASA Astrophysics Data System (ADS)

    Hallar, A. G.; McCubbin, I. B.; Wright, J.

    2007-12-01

    The Desert Research Institute operates a high elevation facility, Storm Peak Laboratory (SPL), located on the Steamboat Springs Ski Resort at an elevation 10,500 ft. SPL provides an ideal location for long-term atmospheric research. The SPL mission statement is to ensure that the laboratory will continue to integrate climate research and education by advancing discovery and understanding within the field of pollution, aerosol and cloud interactions. During the last year, SPL has created two successful outreach programs reaching very different audiences. First, to engage students from local elementary schools, SPL established a 5th grade climate education program. This program is based on a partnership between SPL and Yampatika's&penvironmental educators. Yampatika is a non-profit outdoor environmental education organization. The program spans three days for each school and includes five elementary schools. During the first day, educators from Yampatika visit each classroom to introduce the concepts of climate and weather as well as teach students how to use scientific equipment. During the field program on the second day, students measure and record information about temperature, pressure, relative humidity, wind speed, and particle concentration while they travel to SPL via the gondola (in winter) or Suburban (in fall). Once at the laboratory, students tour the facility, discuss SPL research activities, and explore application of these activities to their curriculum. Following the field trip, Yampatika educators and SPL scientists will visit the school for a follow-up to help children explore concepts, answer questions, and evaluate students" learning. The second program, Geoscience Research at Storm Peak (GRASP), was designed to engage students from underrepresented groups and created a partnership between three Minority Serving Institutions and the University of Nevada, Reno (UNR). Undergraduate students from Tennessee State University, Howard University

  3. Detection of the "cp4 epsps" Gene in Maize Line NK603 and Comparison of Related Protein Structures: An Advanced Undergraduate Experiment

    ERIC Educational Resources Information Center

    Swope, Nicole K.; Fryfogle, Patrick J.; Sivy, Tami L.

    2015-01-01

    A flexible, rigorous laboratory experiment for upper-level biochemistry undergraduates is described that focuses on the Roundup Ready maize line. The work is appropriate for undergraduate laboratory courses that integrate biochemistry, molecular biology, or bioinformatics. In this experiment, DNA is extracted and purified from maize kernel and…

  4. Physical and Chemical Properties of the Copper-Alanine System: An Advanced Laboratory Project

    ERIC Educational Resources Information Center

    Farrell, John J.

    1977-01-01

    An integrated physical-analytical-inorganic chemistry laboratory procedure for use with undergraduate biology majors is described. The procedure requires five to six laboratory periods and includes acid-base standardizations, potentiometric determinations, computer usage, spectrophotometric determinations of crystal-field splitting…

  5. Graduate Teaching Assistants; Critical Colleagues or Casual Components in the Undergraduate Laboratory Learning? An Exploration of the Role of the Postgraduate Teacher in the Sciences

    ERIC Educational Resources Information Center

    Ryan, Barry J.

    2014-01-01

    Laboratory training is key to many science subjects and those that teach the practical laboratory skills maintain a pivotal role in undergraduate science training. Graduate Teaching Assistants (GTAs) are regularly used in higher education institutes to teach these practical lab skills. The GTA can be involved in both laboratory teaching and…

  6. [Advanced data analysis and visualization for clinical laboratory].

    PubMed

    Inada, Masanori; Yoneyama, Akiko

    2011-01-01

    This paper describes visualization techniques that help identify hidden structures in clinical laboratory data. The visualization of data is helpful for a rapid and better understanding of the characteristics of data sets. Various charts help the user identify trends in data. Scatter plots help prevent misinterpretations due to invalid data by identifying outliers. The representation of experimental data in figures is always useful for communicating results to others. Currently, flexible methods such as smoothing methods and latent structure analysis are available owing to the presence of advanced hardware and software. Principle component analysis, which is a well-known technique used to reduce multidimensional data sets, can be carried out on a personal computer. These methods could lead to advanced visualization with regard to exploratory data analysis. In this paper, we present 3 examples in order to introduce advanced data analysis. In the first example, a smoothing spline was fitted to a time-series from the control chart which is not in a state of statistical control. The trend line was clearly extracted from the daily measurements of the control samples. In the second example, principal component analysis was used to identify a new diagnostic indicator for Graves' disease. The multi-dimensional data obtained from patients were reduced to lower dimensions, and the principle components thus obtained summarized the variation in the data set. In the final example, a latent structure analysis for a Gaussian mixture model was used to draw complex density functions suitable for actual laboratory data. As a result, 5 clusters were extracted. The mixed density function of these clusters represented the data distribution graphically. The methods used in the above examples make the creation of complicated models for clinical laboratories more simple and flexible.

  7. Synthesis and Characterization of Europium(III) and Terbium(III) Complexes: An Advanced Undergraduate Inorganic Chemistry Experiment

    ERIC Educational Resources Information Center

    Swavey, Shawn

    2010-01-01

    Undergraduate laboratories rarely involve lanthanide coordination chemistry. This is unfortunate in light of the ease with which many of these complexes are made and the interesting and instructive photophysical properties they entail. The forbidden nature of the 4f transitions associated with the lanthanides is overcome by incorporation of…

  8. Renewable Energy Laboratory Development for Biofuels Advanced Combustion Studies

    SciTech Connect

    Soloiu, Valentin A.

    2012-03-31

    The research advanced fundamental science and applied engineering for increasing the efficiency of internal combustion engines and meeting emissions regulations with biofuels. The project developed a laboratory with new experiments and allowed investigation of new fuels and their combustion and emissions. This project supports a sustainable domestic biofuels and automotive industry creating economic opportunities across the nation, reducing the dependence on foreign oil, and enhancing U.S. energy security. The one year period of research developed fundamental knowledge and applied technology in advanced combustion, emissions and biofuels formulation to increase vehicle's efficiency. Biofuels combustion was investigated in a Compression Ignition Direct Injection (DI) to develop idling strategies with biofuels and an Indirect Diesel Injection (IDI) intended for auxiliary power unit.

  9. Construction, implementation, and evaluation of an undergraduate biology laboratory teaching model

    NASA Astrophysics Data System (ADS)

    Tarrant, Todd M.

    This dissertation documents a time series study in which an undergraduate non-majors biology laboratory was revised, leading to the development of a new teaching model. The course model was developed at a large Midwestern university enrolling about 827 students in 32 sections per semester and using graduate teaching assistants as primary instructors. The majority of the students consisted of freshman and sophomores, with the remainder being juniors and seniors. This dissertation explains the rationale leading to the development and implementation of this educational model using graduate teaching assistants as the primary course instructors and embedded course assessment as evidence of its success. The major components of this model include six major items including: learning community, course design, GTA professional development, course delivery, assessment, and the filter. The major aspects of this model include clear links between instruction, GTA professional development, embedded assessment (student and GTA), course revision, student perceptions, and performance. The model includes the following components: Formal and informal discourse in the learning community, teaching assistant professional development, the use of multiple assessment tools, a filter to guide course evaluation, and redirection and delivery of course content based on embedded formal course assessment. Teaching assistants receive both initial and ongoing professional development throughout the semester in effective instructional pedagogy from an instructor of record. Results for three years of operation show a significant increase in student biology content knowledge and the use of scientific process/critical thinking skills with mean improvement in student performance of 25.5% and 18.9% respectively. Mean attendance for ISB 208L is 95% for the six semesters of this study showing students regularly attend the laboratory classes and remain in the course with a completion rate of 93

  10. Formative evaluation of traditional instruction and cooperative inquiry projects in undergraduate chemistry laboratory courses

    NASA Astrophysics Data System (ADS)

    Panichas, Michael A.

    Reform agendas for practice in undergraduate chemistry are moving curriculum beyond traditional behaviorist teaching strategies to include constructivist approaches, for extending student learning beyond simple mastery of chemistry content (Bunce & Robinson, 1997; Lagowski, 1998; Herron & Nurrenburn, 1999). Yet implementing new strategies requires assessment of their benefit to learning. This study was undertaken to provide a formal and formative evaluation of the curricula in General and Organic chemistry laboratory courses, which are structured with both Traditional expository lab exercises, and a cooperative inquiry exercise called the Open Ended Project. Using a mixed-methodological case study framework, the primary goal of the research was to determine how the inclusion of these teaching strategies impacts student learning in the areas of Academic Achievement and Affective Learning from the perspective of the students enrolled in these lab classes. The findings suggest that the current curriculum structure of including both Traditional Instruction and the Open Ended Project does address students' Academic Achievement and Affective Learning. However, students perceived that these curriculum components each contributed differently to their learning. For Academic Achievement, Traditional Experiments and the Project had a positive impact on students' operational skills, such as how to use and choose lab techniques for performing or designing experiments, as well as their conceptual learning, such as understanding concepts, and relating those concepts during data analysis. Yet for Affective Learning, such as students' sense of confidence, accomplishment, and engagement, the Project, which has a cooperative learning element, had a positive impact on student learning, while Traditional Experiments, which do not have a cooperative learning element, had a moderate negative impact. The findings point to Cooperative Learning as the key element, which makes the positive

  11. Advanced Undergraduate and Early Graduate Physics Students' Misconception about Solar Wind Flow: Evidence of Students' Difficulties in Distinguishing Paradigms

    ERIC Educational Resources Information Center

    Gross, Nicholas A.; Lopez, Ramon E.

    2009-01-01

    Anecdotal evidence has suggested that advanced undergraduate students confuse the spiral structure of the interplanetary magnetic field with the flow of the solar wind. Though it is a small study, this paper documents this misconception and begins to investigate the underlying issues behind it. We present evidence that the traditional presentation…

  12. Are Electrode Caps Worth the Investment? An Evaluation of EEG Methods in Undergraduate Neuroscience Laboratory Courses and Research

    PubMed Central

    Shields, Stephanie M.; Morse, Caitlin E.; Applebaugh, E. Drew; Muntz, Tyler L.; Nichols, David F.

    2016-01-01

    Electroencephalography (EEG) is a common neuroscience technique that is more accessible to undergraduate programs than expensive techniques such as fMRI and single-cell recording. The use of EEG can provide undergraduates with firsthand neuroscience research experience without taking too many financial resources away from a program. There are multiple types of EEG equipment that can be used, including individual electrodes and electrode caps. This study used surveys administered to students who were in a neuroscience laboratory course, conducting research, or participating in research in order to discern which of these two EEG setups is preferred by undergraduates. According to average reaction scores calculated from the surveys, laboratory students tended to prefer individual electrodes over electrode caps, and when explicitly asked about their overall preference, a majority of laboratory students chose individual electrodes over electrode caps. Additionally, comparable levels of improvement in learning objectives and the quality of data collected in laboratory sessions were found across methods. Student researchers’ ratings revealed a marginal preference for caps over individual electrodes, and all 5 researchers surveyed chose caps on a discriminate choice question. Research participants’ ratings of caps and individual electrodes, however, were not significantly different. These results do not point to a concrete recommendation of one setup over the other but rather suggest that either setup could be a viable option. Therefore, we conclude that programs can comfortably decide which to use based on their own needs and resources as well as the relative advantages and disadvantages of each setup. For example, individual electrodes may be better for programs with low budgets looking to introduce students to EEG data recording, whereas electrode caps may be better for programs looking to better prepare students for future EEG research or to perform multichannel

  13. Quality of Undergraduate Physics Students' Written Scientific Arguments: How to Promote Students' Appropriation of Scientific Discourse in Physics Laboratory Reports?

    NASA Astrophysics Data System (ADS)

    Aydeniz, Mehmet; Yeter-Aydeniz, Kubra

    2015-03-01

    In this study we challenged 18 undergraduate physics students to develop four written scientific arguments across four physics labs: 1) gravity-driven acceleration, 2) conservation of mechanical energy, 3) conservation of linear momentum and 4) boyle's law, in a mechanics and thermodynamics laboratory course. We evaluated quality of the written scientific arguments developed by the participants using the Claim, Evidence, Reasoning and Rebuttal (CERR) rubric. The results indicate that while students developed adequate scientific explanations that summarized the findings of their experiments, they experienced unique difficulties in using a persuasive and critical discourse in their written arguments. Students experienced the most difficulty in considering alternative explanations in formulating their written scientific arguments. We elaborate on the implications of these findings for teaching physics laboratories and assessing students' learning in physics laboratories. We especially focus on the importance of framing in helping students to appropriate the epistemic norms of science in writing scientific arguments.

  14. [Development of advanced educational programs, including research programs, for undergraduate students in National Universities: the facts in 2010].

    PubMed

    Kurosaki, Yuji; Tomioka, Yoshihisa; Santa, Tomofumi; Kitamura, Yoshihisa

    2012-01-01

    This article summarizes detailed facts obtained from the questionnaire conducted in 2010 at about 14 National Universities on the topic of "Research programs and advanced educational programs for undergraduate students". The contents of the questionnaire included: (1) Research programs based on the coalition of university and hospital and/or community pharmacy, other Graduate Schools, such as School of Medicine etc., and the University Hospital, (2) Educational systems for the achievement of research programs and their research outcomes, (3) Research programs based on pharmacist practices, (4) Ongoing advanced educational programs for undergraduate students, taking advantage of the coalition with Graduate School, School of Medicine (and Dentistry), and University Hospital. Some of the advanced educational programs outlined in this questionnaire will be carried out by our group in the coming years and the educational benefits together with associated problems shall as well be clarified. This approach will be informative for the development of the leader-oriented pharmacist programs for the college of Pharmacy.

  15. The advanced light source at the Lawrence Berkeley laboratory

    NASA Astrophysics Data System (ADS)

    Jackson, Alan

    1991-05-01

    The Advanced Light Source (ALS), a national facility currently under construction at the Lawrence Berkeley Laboratory (LBL), is a third-generation synchrotron light source designed to produce extremely bright beams of synchrotron radiation, in the energy range from a few eV to 10 keV. The design is based on a 1-1.9 GeV electron storage ring (optimized at 1.5 GeV), and utilizes special magnets, known as undulators and wigglers (collectively referred to as insertion devices), to generate the radiation. In this paper we describe the main accelerator components of the ALS, the variety of insertion devices, the radiation spectra expected from these devices, and the complement of experiments that have been approved for initial operation, starting in April 1993.

  16. The Advanced Light Source at Lawrence Berkeley Laboratory

    NASA Astrophysics Data System (ADS)

    Robinson, A. L.; Perera, R. C. C.; Schlachter, A. S.

    1992-01-01

    The Advanced Light Source (ALS) at the Lawrence Berkeley Laboratory (LBL), scheduled to be operational in the spring of 1993 as a U.S. Department of Energy national user facility, will be a next-generation source of soft x-ray and ultraviolet (XUV) synchrotron radiation. Undulators will provide the world's brightest synchrotron radiation at photon energies from below 10 eV to above 2 keV; wiggler and bend-magnet radiation will extend the spectral coverage with high fluxes above 10 keV. These capabilities will support an extensive research program in a broad spectrum of scientific and technological areas in which XUV radiation is used to study and manipulate matter in all its varied gaseous, liquid, and solid forms. The ALS will also serve those interested in developing the fabrication technology for microstructures and nanostructures, as well as for characterizing them.

  17. Measurement of phosphorylated extracellular signal-regulated kinase 1 and 2 in an undergraduate teaching laboratory with ALPHAscreen technology.

    PubMed

    Hay, Debbie L

    2009-03-17

    Teaching the practical aspects of signal transduction to large undergraduate classes can be challenging when there is only a finite time frame in which to engage in laboratory activities. This teaching resource describes the use of bead-based ALPHAscreen technology for a class of 300 second-year biochemistry students, exposing the next generation of researchers to cutting-edge technology. Although in this case phosphorylated extracellular signal-regulated kinase 1 and 2 were measured, this technology is applicable to the measurement of many different signaling components. This resource provides a practical guide for instructors and exemplifies how such traditionally high-throughput research technologies can be used as teaching tools.

  18. The Genomics Education Partnership: Successful Integration of Research into Laboratory Classes at a Diverse Group of Undergraduate Institutions

    PubMed Central

    Shaffer, Christopher D.; Alvarez, Consuelo; Bailey, Cheryl; Barnard, Daron; Bhalla, Satish; Chandrasekaran, Chitra; Chandrasekaran, Vidya; Chung, Hui-Min; Dorer, Douglas R.; Du, Chunguang; Eckdahl, Todd T.; Poet, Jeff L.; Frohlich, Donald; Goodman, Anya L.; Gosser, Yuying; Hauser, Charles; Hoopes, Laura L.M.; Johnson, Diana; Jones, Christopher J.; Kaehler, Marian; Kokan, Nighat; Kopp, Olga R.; Kuleck, Gary A.; McNeil, Gerard; Moss, Robert; Myka, Jennifer L.; Nagengast, Alexis; Morris, Robert; Overvoorde, Paul J.; Shoop, Elizabeth; Parrish, Susan; Reed, Kelynne; Regisford, E. Gloria; Revie, Dennis; Rosenwald, Anne G.; Saville, Ken; Schroeder, Stephanie; Shaw, Mary; Skuse, Gary; Smith, Christopher; Smith, Mary; Spana, Eric P.; Spratt, Mary; Stamm, Joyce; Thompson, Jeff S.; Wawersik, Matthew; Wilson, Barbara A.; Youngblom, Jim; Leung, Wilson; Buhler, Jeremy; Mardis, Elaine R.; Lopatto, David

    2010-01-01

    Genomics is not only essential for students to understand biology but also provides unprecedented opportunities for undergraduate research. The goal of the Genomics Education Partnership (GEP), a collaboration between a growing number of colleges and universities around the country and the Department of Biology and Genome Center of Washington University in St. Louis, is to provide such research opportunities. Using a versatile curriculum that has been adapted to many different class settings, GEP undergraduates undertake projects to bring draft-quality genomic sequence up to high quality and/or participate in the annotation of these sequences. GEP undergraduates have improved more than 2 million bases of draft genomic sequence from several species of Drosophila and have produced hundreds of gene models using evidence-based manual annotation. Students appreciate their ability to make a contribution to ongoing research, and report increased independence and a more active learning approach after participation in GEP projects. They show knowledge gains on pre- and postcourse quizzes about genes and genomes and in bioinformatic analysis. Participating faculty also report professional gains, increased access to genomics-related technology, and an overall positive experience. We have found that using a genomics research project as the core of a laboratory course is rewarding for both faculty and students. PMID:20194808

  19. Papers from U.S. Department of Energy Science Undergraduate Laboratory Internship Program (SULI) 2005

    SciTech Connect

    Quinn, Helen,; /SLAC

    2005-12-16

    Polarization measurements at X-ray and gamma-ray energies can provide crucial information on the emission region around massive compact objects such as black holes and neutron stars. The Polarized Gamma-ray Observer (PoGO) is a new balloon-borne instrument designed to measure polarization from such astrophysical objects in the 30-100 keV range, under development by an international collaboration with members from United States, Japan, Sweden and France. The PoGO instrument has been designed by the collaboration and several versions of prototype models have been built at SLAC. The purpose of this experiment is to test the latest prototype model with a radioactive gamma-ray source. For this, we have to polarize gamma-rays in a laboratory environment. Unpolarized gamma-rays from Am241 (59.5 keV) were Compton scattered at around 90 degrees for this purpose. Computer simulation of the scattering process in the setup predicts a 86% polarization. The polarized beam was then used to irradiate the prototype PoGO detector. The data taken in this experiment showed a clear polarization signal, with a measured azimuthal modulation factor of 0.35 {+-} 0.02. The measured modulation is in very close agreement with the value expected from a previous beam test study of a polarized gamma-ray beam at the Argonne National Laboratories Advanced Photon Source. This experiment has demonstrated that the PoGO instrument (or any other polarimeter in the energy range) can be tested in a libratory with a simple setup to a similar accuracy.

  20. Organic Materials in the Undergraduate Laboratory: Microscale Synthesis and Investigation of a Donor-Acceptor Molecule

    ERIC Educational Resources Information Center

    Pappenfus, Ted M.; Schliep, Karl B.; Dissanayake, Anudaththa; Ludden, Trevor; Nieto-Ortega, Belen; Lopez Navarrete, Juan T.; Ruiz Delgado, M. Carmen; Casado, Juan

    2012-01-01

    A series of experiments for undergraduate courses (e.g., organic, physical) have been developed in the area of small molecule organic materials. These experiments focus on understanding the electronic and redox properties of a donor-acceptor molecule that is prepared in a convenient one-step microscale reaction. The resulting intensely colored…

  1. Undergraduate Laboratory Experiment Facilitating Active Learning of Concepts in Transport Phenomena: Experiment with a Subliming Solid

    ERIC Educational Resources Information Center

    Utgikar, Vivek P.

    2015-01-01

    An experiment based on the sublimation of a solid was introduced in the undergraduate Transport Phenomena course. The experiment required the students to devise their own apparatus and measurement techniques. The theoretical basis, assignment of the experiment, experimental results, and student/instructor observations are described in this paper.…

  2. Fighting Tuberculosis in an Undergraduate Laboratory: Synthesizing, Evaluating and Analyzing Inhibitors

    ERIC Educational Resources Information Center

    Daniels, David; Berkes, Charlotte; Nekoie, Arjan; Franco, Jimmy

    2015-01-01

    A drug discovery project has been successfully implemented in a first-year general, organic, and biochemistry (GOB) health science course and second-year organic undergraduate chemistry course. This project allows students to apply the fundamental principles of chemistry and biology to a problem of medical significance, practice basic laboratory…

  3. Student Perceptions of an Upper-Level, Undergraduate Human Anatomy Laboratory Course without Cadavers

    ERIC Educational Resources Information Center

    Wright, Shirley J.

    2012-01-01

    Several programs in health professional education require or are considering requiring upper-level human anatomy as prerequisite for their applicants. Undergraduate students are confronted with few institutions offering such a course, in part because of the expense and logistical issues associated with a cadaver-based human anatomy course. This…

  4. A Computer-Interfaced O2 Probe: Instrumentation for Undergraduate Chemistry Laboratories.

    ERIC Educational Resources Information Center

    Adamson, Gary E.; Nakhleh, Mary B.; Zimmerman, James R.

    1997-01-01

    Describes interfacing a hand-held oxygen probe with a microcomputer and suggests experiments for undergraduate chemistry courses that could facilitate student understanding of aquatic environmental processes which involve dissolved oxygen. Data can be analyzed through the program or exported into other software. Presents results of an experiment…

  5. Synthesis and Characterization of Calixarene Tetraethers: An Exercise in Supramolecular Chemistry for the Undergraduate Organic Laboratory

    ERIC Educational Resources Information Center

    Debbert, Stefan L.; Hoh, Bradley D.; Dulak, David J.

    2016-01-01

    In this experiment for an introductory undergraduate organic chemistry lab, students tetraalkylate tertbutylcalix[4]arene, a bowl-shaped macrocyclic oligophenol, and examine the supramolecular chemistry of the tetraether product by proton nuclear magnetic resonance (NMR) spectroscopy. Complexation with a sodium ion reduces the conformational…

  6. Physico-Geometrical Kinetics of Solid-State Reactions in an Undergraduate Thermal Analysis Laboratory

    ERIC Educational Resources Information Center

    Koga, Nobuyoshi; Goshi, Yuri; Yoshikawa, Masahiro; Tatsuoka, Tomoyuki

    2014-01-01

    An undergraduate kinetic experiment of the thermal decomposition of solids by microscopic observation and thermal analysis was developed by investigating a suitable reaction, applicable techniques of thermal analysis and microscopic observation, and a reliable kinetic calculation method. The thermal decomposition of sodium hydrogen carbonate is…

  7. Rapid Multistep Synthesis of a Bioactive Peptidomimetic Oligomer for the Undergraduate Laboratory

    ERIC Educational Resources Information Center

    Utku, Yeliz; Rohatgi, Abhinav; Yoo, Barney; Kirshenbaum, Kent; Zuckermann, Ronald N.; Pohl, Nicola L.

    2010-01-01

    Peptidomimetic compounds are increasingly important in drug-discovery applications. We introduce the synthesis of an N-substituted glycine oligomer, a bioactive "peptoid" trimer. The six-step protocol is conducted on solid-phase resin, enabling the synthesis to be performed by undergraduate organic chemistry students. This synthesis lab was…

  8. Use of Microcomputers in the Undergraduate Chemistry Laboratory: An Absorption Spectrum Experiment.

    ERIC Educational Resources Information Center

    Terry, Ronald J.; And Others

    1989-01-01

    Describes a computer program designed to enable undergraduate students to apply computer skills for data acquisition and processing in experimental chemistry. An example is given that examines the absorption spectra of conjugated molecules such as carbocyanine dyes, and the free electron model is explained. (six references) (LRW)

  9. A Model System for the Study of Gene Expression in the Undergraduate Laboratory

    ERIC Educational Resources Information Center

    Hargadon, Kristian M.

    2016-01-01

    The flow of genetic information from DNA to RNA to protein, otherwise known as the "central dogma" of biology, is one of the most basic and overarching concepts in the biological sciences. Nevertheless, numerous studies have reported student misconceptions at the undergraduate level of this fundamental process of gene expression. This…

  10. Hydrogen Storage Experiments for an Undergraduate Laboratory Course--Clean Energy: Hydrogen/Fuel Cells

    ERIC Educational Resources Information Center

    Bailey, Alla; Andrews, Lisa; Khot, Ameya; Rubin, Lea; Young, Jun; Allston, Thomas D.; Takacs, Gerald A.

    2015-01-01

    Global interest in both renewable energies and reduction in emission levels has placed increasing attention on hydrogen-based fuel cells that avoid harm to the environment by releasing only water as a byproduct. Therefore, there is a critical need for education and workforce development in clean energy technologies. A new undergraduate laboratory…

  11. Analysis of Currently Available Analgesic Tablets by Modern Liquid Chromatography: An Undergraduate Laboratory Introduction to HPLC.

    ERIC Educational Resources Information Center

    Kagel, R. A.; Farwell, S. O.

    1983-01-01

    Background information, procedures, and results, are provided for an undergraduate experiment in which analgesic tablets are analyzed using liquid chromatography. The experiment, an improved, modified version of the Waters Associates Inc. experiment, is simple to prepare, requiring little glassware and minimal sample manipulation by students. (JN)

  12. Learning Chemistry Research Outside the Laboratory: Novel Graduate and Undergraduate Courses in Research Methodology.

    ERIC Educational Resources Information Center

    Schildcrout, Steven M.

    2002-01-01

    Describes two courses in research methodology, required respectively for graduate and undergraduate chemistry students as they begin research projects. The courses include traditional classroom sessions with discussion as well as exercises in writing and speaking, critiquing a journal article and a thesis, and preparing a research proposal.…

  13. A Cost-Effective Atomic Force Microscope for Undergraduate Control Laboratories

    ERIC Educational Resources Information Center

    Jones, C. N.; Goncalves, J.

    2010-01-01

    This paper presents a simple, cost-effective and robust atomic force microscope (AFM), which has been purposely designed and built for use as a teaching aid in undergraduate controls labs. The guiding design principle is to have all components be open and visible to the students, so the inner functioning of the microscope has been made clear to…

  14. A Gas-Sensor-Based Urea Enzyme Electrode: Its Construction and Use in the Undergraduate Laboratory.

    ERIC Educational Resources Information Center

    Riechel, Thomas L.

    1984-01-01

    Describes an undergraduate experiment for the potentiometric determination of urea based on the physical entrapment of urease on the tip of an ammonia gas sensor. An advantage of this technique is the ease with which the ammonia electrode can be converted to a urea electrode. (JN)

  15. Verification of Compton Collision and Klein-Nishina Formulas--An Undergraduate Laboratory Experiment

    ERIC Educational Resources Information Center

    Singhal, R. P.; Burns, A. J.

    1978-01-01

    Describes an experiment to verify the Compton collision formula and the angular dependance of the Klein-Nishina formula. Equipment used is a 1-mCi(137)Cs source, 2x2 in. NaI detector and a multichannel analyzer. Suitable for honor undergraduates. (Author/GA)

  16. An Undergraduate Laboratory Class Using CRISPR/Cas9 Technology to Mutate Drosophila Genes

    ERIC Educational Resources Information Center

    Adame, Vanesa; Chapapas, Holly; Cisneros, Marilyn; Deaton, Carol; Deichmann, Sophia; Gadek, Chauncey; Lovato, TyAnna L.; Chechenova, Maria B.; Guerin, Paul; Cripps, Richard M.

    2016-01-01

    CRISPR/Cas9 genome editing technology is used in the manipulation of genome sequences and gene expression. Because of the ease and rapidity with which genes can be mutated using CRISPR/Cas9, we sought to determine if a single-semester undergraduate class could be successfully taught, wherein students isolate mutants for specific genes using…

  17. A Writing-Intensive, Methods-Based Laboratory Course for Undergraduates

    ERIC Educational Resources Information Center

    Colabroy, Keri L.

    2011-01-01

    Engaging undergraduate students in designing and executing original research should not only be accompanied by technique training but also intentional instruction in the critical analysis and writing of scientific literature. The course described here takes a rigorous approach to scientific reading and writing using primary literature as the model…

  18. Aligning the Undergraduate Organic Laboratory Experience with Professional Work: The Centrality of Reliable and Meaningful Data

    ERIC Educational Resources Information Center

    Alaimo, Peter J.; Langenhan, Joseph M.; Suydam, Ian T.

    2014-01-01

    Many traditional organic chemistry lab courses do not adequately help students to develop the professional skills required for creative, independent work. The overarching goal of the new organic chemistry lab series at Seattle University is to teach undergraduates to think, perform, and behave more like professional scientists. The conversion of…

  19. Aerobic Alcohol Oxidation Using a Copper(I)/TEMPO Catalyst System: A Green, Catalytic Oxidation Reaction for the Undergraduate Organic Chemistry Laboratory

    ERIC Educational Resources Information Center

    Hill, Nicholas J.; Hoover, Jessica M.; Stahl, Shannon S.

    2013-01-01

    Modern undergraduate organic chemistry textbooks provide detailed discussion of stoichiometric Cr- and Mn-based reagents for the oxidation of alcohols, yet the use of such oxidants in instructional and research laboratories, as well as industrial chemistry, is increasingly avoided. This work describes a laboratory exercise that uses ambient air as…

  20. Determining the Transference Number of H[superscript +](aq) by a Modified Moving Boundary Method: A Directed Study for the Undergraduate Physical Chemistry Laboratory

    ERIC Educational Resources Information Center

    Dabke, Rajeev B.; Gebeyehu, Zewdu; Padelford, Jonathan

    2012-01-01

    A directed study for the undergraduate physical chemistry laboratory for determining the transference number of H[superscript +](aq) using a modified moving boundary method is presented. The laboratory study combines Faraday's laws of electrolysis with mole ratios and the perfect gas equation. The volume of hydrogen gas produced at the cathode is…

  1. Spectroscopy in Sol-Gel Matrices: An Open-Ended Laboratory Experience for Upper-Level Undergraduates

    NASA Astrophysics Data System (ADS)

    Higginbotham, Catrena; Pike, Charles F.; Rice, Jeanette K.

    1998-04-01

    Guided-inquiry/cooperative learning laboratory experiences encourage critical thinking, problem- solving and teamwork skills in students, and have been proposed for many undergraduate laboratories, particularly general and organic. Fewer reports have appeared for upper level courses such as instrumental analysis. In this report, we discuss our recent conversion of our Instrumental Analysis:Spectroscopy course to guided-inquiry format, and describe an appropriate novel experiment. Sol-gel technology is incorporated as a means to investigate spectral properties of various organic molecules. Students are exposed to silicate glass synthesis as well as modern spectroscopic techniques. Experimental details are researched, designed and executed by the students, and the results presented in both written format as well as oral presentation/examination.

  2. Experience revising an advanced-undergraduate/beginning-graduate fluid mechanics textbook

    NASA Astrophysics Data System (ADS)

    Dowling, David

    2012-11-01

    In the fall of 2009, Elsevier Inc. approached me about taking over as the lead author of the fluid mechanics textbook by P. K. Kundu and I. M. Cohen. I subsequently agreed and this presentation provides the story of the process and the approach taken to revising this fluid mechanics textbook which has been in print for approximately 15 years. The goal of the revision was to produce an excellent textbook for second courses in fluid mechanics taken by advanced undergraduate and beginning graduate students while maintaining the book's appeal to instructors who used prior editions. Thus, I sought to maintain or expand the text's fluid mechanics content, while adjusting the text's tone so that this content might be more readily reached by students who may have had only one prior course in fluid mechanics, or who may not specialize in fluid mechanics but do possess appropriate mathematical skills. The entire revision process involved seven steps: (i) formulating a revision plan that was independently reviewed, (ii) agreeing to a formal contract with deadlines, (iii) revising the text, figures, and front matter, (iv) proof reading and correcting copy-edited text, (v) correcting page proofs, (vi) generating the solutions manual, and (vii) tabulating errata. Formulating and executing the

  3. Using Recent Planetary Science Data to Develop Advanced Undergraduate Physics and Astronomy Activities

    NASA Astrophysics Data System (ADS)

    Steckloff, Jordan; Lindell, Rebecca

    2016-10-01

    Teaching science by having students manipulate real data is a popular trend in astronomy and planetary science education. However, many existing activities simply couple this data with traditional "cookbook" style verification labs. As with most topics within science, this instructional technique does not enhance the average students' understanding of the phenomena being studied. Here we present a methodology for developing "science by doing" activities that incorporate the latest discoveries in planetary science with up-to-date constructivist pedagogy to teach advanced concepts in Physics and Astronomy. In our methodology, students are first guided to understand, analyze, and plot real raw scientific data; develop and test physical and computational models to understand and interpret the data; finally use their models to make predictions about the topic being studied and test it with real data.To date, two activities have been developed according to this methodology: Understanding Asteroids through their Light Curves (hereafter "Asteroid Activity"), and Understanding Exoplanetary Systems through Simple Harmonic Motion (hereafter "Exoplanet Activity"). The Asteroid Activity allows students to explore light curves available on the Asteroid Light Curve Database (ALCDB) to discover general properties of asteroids, including their internal structure, strength, and mechanism of asteroid moon formation. The Exoplanet Activity allows students to investigate the masses and semi-major axes of exoplanets in a system by comparing the radial velocity motion of their host star to that of a coupled simple harmonic oscillator. Students then explore how noncircular orbits lead to deviations from simple harmonic motion. These activities will be field tested during the Fall 2016 semester in an advanced undergraduate mechanics and astronomy courses at a large Midwestern STEM-focused university. We will present the development methodologies for these activities, description of the

  4. Urban Field Experiences for Undergraduate Liberal Arts Students: Using Compromised Environments as Living Laboratories

    NASA Astrophysics Data System (ADS)

    MacAvoy, S. E.; Knee, K.

    2015-12-01

    While urban environments may lack the beauty of relatively pristine field sites, they can be used to deliver an effective demonstration of actual environmental damage. Students demanding applied field experiences from their undergraduate environmental science programs can be well served in urban settings. Here, we present strategies for integrating degraded urban systems into the undergraduate field experience. Urban locations provide an opportunity for a different type of local "field-work" than would otherwise be available. In the upper-level undergraduate Environmental Methods class, we relied on a National Park area located a 10-minute walk from campus for most field exercises. Activities included soil analysis, measuring stream flow and water quality parameters, dendrochronology, and aquatic microbe metabolism. In the non-majors class, we make use of our urban location to contrast water quality in parks and highly channelized urban streams. Students spend labs immersed in streams and wetlands heavily impacted by the urban runoff their city generates. Here we share lesson plans and budgets for field activities that can be completed during a class period of 2.5 hours with a $75 course fee, show how these activities help students gain quantitative competency.

  5. Use of the Berkeley Physics Laboratory to Teach an Advanced Physics Course

    ERIC Educational Resources Information Center

    Logan, James David

    1973-01-01

    Discusses a course, centered around 32 experiments taught for advanced students, designed to develop a laboratory strongly suggestive of contemporary research using relatively sophisticated apparatus. Its unique advantage lies in enriching advanced physics curriculum. (DF)

  6. Zebrafish development and genetics: introducing undergraduates to developmental biology and genetics in a large introductory laboratory class.

    PubMed

    D'Costa, Allison; Shepherd, Iain T

    2009-06-01

    We have taken advantage of the strengths of the zebrafish model system to introduce developmental biology and genetics to undergraduates in their second semester of the Introductory Biology course at Emory. We designed a 6-week laboratory module based on research being undertaken by faculty in the department, and incorporated experiments that used current research methods including bioinformatics. Students undertook a range of experiments including direct observation of live wild-type zebrafish at different stages of embryogenesis, whole-mount in situ hybridization of mutant and wild-type embryos, vital dye staining of mutant and wild-type embryos, and pharmacological treatments to perturb normal development. These laboratories engaged the students by providing a hands-on, research-centered experience, while also enhancing their written (worksheets and laboratory reports) and oral (group presentation) communication skills. We describe the proceedings of each lab and the logistics of preparing and running these labs for 400-500 students (120 students taking lab each day), and provide a preliminary assessment of the success of the laboratories data based on student evaluations.

  7. Using an ePortfolio system as an electronic laboratory notebook in undergraduate biochemistry and molecular biology practical classes.

    PubMed

    Johnston, Jill; Kant, Sashi; Gysbers, Vanessa; Hancock, Dale; Denyer, Gareth

    2014-01-01

    Despite many apparent advantages, including security, back-up, remote access, workflow, and data management, the use of electronic laboratory notebooks (ELNs) in the modern research laboratory is still developing. This presents a challenge to instructors who want to give undergraduate students an introduction to the kinds of data curation and notebook keeping skills that will inevitably be required as ELNs penetrate normal laboratory practice. An additional problem for the teacher is that ELNs do not generally have student-administrative functions and are prohibitively expensive. In this report, we describe the use and impact of an ePortfolio system as a surrogate ELN. Introduction of the system led to several pedagogic outcomes, namely: increased preparedness of students for class, encouragement of creativity and reflection with respect to experimental methods, greatly enhanced engagement between students and tutors, and it gave instructors the ability to scrutinize original data files and monitor student-tutor feedback cycles. However, implementation led to a disruption of tutor workloads and incurred new levels of accountability that threatened to undermine the initiative. Through course evaluations and other reflective processes, we reached an appreciation of how an ELN should be introduced into practical class teaching so that it not only becomes an appropriate aid for teaching the laboratory experience, but also becomes a life-long resource for students.

  8. COMPRES Mineral Physics Educational Modules for Advanced Undergraduates and Graduate Students

    NASA Astrophysics Data System (ADS)

    Burnley, P. C.; Thomas, S.

    2012-12-01

    The Consortium for Materials Properties Research in Earth Sciences (COMPRES) is a community-based consortium whose goal is to advance and facilitate experimental high pressure research in the Earth Sciences. An important aspect of this goal is sharing our knowledge with the next generation of researchers. To facilitate this, we have created a group of web-based educational modules on mineral physics topics. The modules reside in the On Cutting Edge, Teaching Mineralogy collection on the Science Education Resource Center (SERC) website. Although the modules are designed to function as part of a full semester course, each module can also stand alone. Potential users of the modules include mineral physics faculty teaching "bricks and mortar" classes at their own institutions, or in distance education setting, mineralogy teachers interested in including supplementary material in their mineralogy class, undergraduates doing independent study projects and graduate students and colleagues in other sub-disciplines who wish to brush up on a mineral physics topic. We used the modules to teach an on-line course entitled "Introduction to Mineral Physics" during the spring 2012 semester. More than 20 students and postdocs as well as 15 faculty and senior scientists participated in the course which met twice weekly as a webinar. Recordings of faculty lectures and student-led discussions of journal articles are now available upon request and edited versions of the lectures will be incorporated into the educational modules. Our experience in creating the modules and the course indicates that the use of 1) community-generated internet-based resources and 2) webinars to enable shared teaching between faculty at different universities, has the potential to both enrich graduate education and create efficiencies for university faculty.;

  9. Using Zebrafish to Implement a Course-Based Undergraduate Research Experience to Study Teratogenesis in Two Biology Laboratory Courses.

    PubMed

    Sarmah, Swapnalee; Chism, Grady W; Vaughan, Martin A; Muralidharan, Pooja; Marrs, Jim A; Marrs, Kathleen A

    2016-08-01

    A course-based undergraduate research experience (CURE) spanning three semesters was introduced into freshman and sophomore biology classes, with the hypothesis that participation in a CURE affects skills in research, communication, and collaboration, which may help students persist in science. Student research projects were centered on the hypothesis that nicotine and caffeine exposure during early development affects gastrulation and heart development in zebrafish. First, freshmen generated original data showing distinct effects of embryonic nicotine and caffeine exposure on zebrafish heart development and function. Next, Cell Biology laboratory students continued the CURE studies and identified novel teratogenic effects of nicotine and caffeine during gastrulation. Finally, new freshmen continued the CURE research, examining additional toxicant effects on development. Students designed new protocols, made measurements, presented results, and generated high-quality preliminary data that were studied in successive semesters. By implementing this project, the CURE extended faculty research and provided a scalable model to address national goals to involve more undergraduates in authentic scientific research. In addition, student survey results support the hypothesis that CUREs provide significant gains in student ability to (1) design experiments, (2) analyze data, and (3) make scientific presentations, translating into high student satisfaction and enhanced learning.

  10. Parallel Combinatorial Synthesis of Azo Dyes: A Combinatorial Experiment Suitable for Undergraduate Laboratories

    ERIC Educational Resources Information Center

    Gung, Benjamin W.; Taylor, Richard T.

    2004-01-01

    An experiment in the parallel synthesis of azo dyes that demonstrates the concepts of structure-activity relationships and chemical diversity with vivid colors is described. It is seen that this experiment is suitable for the second-semester organic chemistry laboratory and also for the one-semester organic laboratory.

  11. Synthesis and Biological Testing of Penicillins: An Investigative Approach to the Undergraduate Teaching Laboratory

    ERIC Educational Resources Information Center

    Whitaker, Ragnhild D.; Truhlar, Laura M.; Yksel, Deniz; Walt, David R.; Williams, Mark D.

    2010-01-01

    The development and implementation of a research-based organic chemistry laboratory experiment is presented. The experiment was designed to simulate a scientific research environment, involve students in critical thinking, and develop the student's ability to analyze and present research-based data. In this experiment, a laboratory class…

  12. Using Laboratory Experiments and Circuit Simulation IT Tools in an Undergraduate Course in Analog Electronics

    ERIC Educational Resources Information Center

    Baltzis, Konstantinos B.; Koukias, Konstantinos D.

    2009-01-01

    Laboratory-based courses play a significant role in engineering education. Given the role of electronics in engineering and technology, laboratory experiments and circuit simulation IT tools are used in their teaching in several academic institutions. This paper discusses the characteristics and benefits of both methods. The content and structure…

  13. Using Model Organisms in an Undergraduate Laboratory to Link Genotype, Phenotype, and the Environment

    ERIC Educational Resources Information Center

    Jacobs-McDaniels, Nicole L.; Maine, Eleanor M.; Albertson, R. Craig; Wiles, Jason R.

    2013-01-01

    We developed laboratory exercises using zebrafish ("Danio rerio") and nematodes ("Caenorhabditis elegans") for a sophomore-level Integrative Biology Laboratory course. Students examined live wildtype zebrafish at different stages of development and noted shifts occurring in response to "fgf8a" deficiency. Students were introduced to development in…

  14. Learning Chemistry Research outside the Laboratory: New Graduate and Undergraduate Courses in Research Methodology

    NASA Astrophysics Data System (ADS)

    Schildcrout, Steven M.

    2002-11-01

    Without guidance, research students may delay choosing a research advisor and a research problem or may encounter difficulties in understanding the goal and significance of their work and staying focused on it. The students may find writing the thesis or final report to be problematic. To ameliorate such problems at Youngstown State University, we help students structure their research experience by using two courses in research methodology, required respectively for graduate and undergraduate chemistry students as they begin their research projects. The courses include traditional classroom sessions with discussion, as well as exercises in writing and speaking, critiquing a journal article and thesis, and preparing a research proposal. Students work with both the course instructor and the research advisor, integrating the coursework into the students' research projects. Although such courses are not widely used elsewhere, our students and faculty find these courses valuable.

  15. A low-cost polarimeter for an undergraduate laboratory to study the polarization pattern of skylight

    NASA Astrophysics Data System (ADS)

    Abayaratne, Chula P.; Bandara, Vibodha

    2017-03-01

    A simple, low-cost, fully automated polarimeter, which demonstrates fundamental properties of skylight scattering and polarization for undergraduate physics students, is described. The polarimeter includes a microprocessor-based control unit, a Sun tracker, an elevation-azimuth mount with two degrees of freedom, and a polarization sensor unit equipped with a light-dependent resistor for measuring light intensity. Results obtained in the principal plane of the Sun using the polarimeter on a relatively clear day, together with the theoretically expected results for a molecular atmosphere, are presented. A root-mean-square error comparison indicates fairly good agreement between theory and experiment. Construction and experimentation with the polarimeter will provide students with insight into important physical concepts involved in skylight scattering and polarization as well as improve their instrumentation capabilities.

  16. Undergraduates at Sea and in the Laboratory Conducting Habitat Mapping Using Multibeam and Sidescan Sonar

    NASA Astrophysics Data System (ADS)

    Sautter, L. R.; Harris, M. S.

    2008-12-01

    During the last five years, undergraduate students at the College of Charleston have had numerous opportunities to take part in the college's Transect Program and sail aboard research vessels on 2-5 day cruises to study the continental shelf. The program's purpose is to train students in oceanographic research while developing a long-term information geodatabase to characterize and monitor essential fish habitats, and to map seafloor geomorphology. During these cruises students take the lead to conduct a variety of research investigations which include hydrographic surveys of the seafloor using sidescan sonar, multibeam bathymetry, and video collected using a remotely operated vehicle and during SCUBA dives. Following the data collection cruises, students have enrolled in semester-long research courses to analyze data and document results through poster and oral presentations. More than 60 students have taken part in at least one of 6 programs. In the past two years, the NOAA Ship NANCY FOSTER has provided invaluable sea time to conduct multibeam surveys of the mid- and outer continental shelf off Charleston, so that the 22 participating Transect students have focused their work on seafloor mapping, and have become trained in state-of-the art CARIS multibeam and sidescan sonar processing software. Most of these students have presented their results at professional meetings, and manuscripts are currently in preparation. Students have had numerous post-program opportunities to conduct further research at sea and in the lab. They have collaborated with NOAA scientists and other investigators, conducting bathymetry data processing and analysis from other regions. Most recently, two program graduates worked with University of Washington investigators to map sites for the Ocean Observatory Initiative Regional Scale Nodes. Several students have been contracted or hired as hydrographic survey technicians, while others have gone to graduate school to continue their work

  17. Gamma-Nonanoic Lactone: Synthesis of a Fragrance and Flavor Enhancer in the Undergraduate Laboratory.

    ERIC Educational Resources Information Center

    Bunce, Richard A.; Reeves, Henry D.

    1990-01-01

    Described is an experiment in which students are able to synthesize an unnatural compound having the odor and flavor of coconuts. Laboratory equipment, procedures, and analysis of the product are discussed. (CW)

  18. An investigation of student understanding in the undergraduate organic chemistry laboratory

    NASA Astrophysics Data System (ADS)

    Grutsch, John Leo, Jr.

    Laboratory activities in organic chemistry involve a mixture of sophisticated logic and empirical observation that requires the integration of mechanistic thought, laboratory technique, and problem-solving skills. In an effort to understand how students develop the thought processes and problem-solving skills necessary for laboratory work in organic chemistry, student understanding of how the interaction between a reaction system (reactants or starting material(s), reagent(s), and/or solvent), experimental variables (pH, temperature, concentrations, etc), provides a result of interest (yield, selectivity, purity, etc.) for an experiment performed in the organic chemistry laboratory was investigated through the collection of responses to questions posed on pre-laboratory quizzes followed by in-depth interviews during which student volunteers discussed their responses along with their experiences in the laboratory. The conceptual change theory of learning which assumes new conceptions are understood, judged, acquired, or rejected in a conceptual context was used as a theoretical paradigm to examine students responses to questions posed on pre-laboratory quizzes and transcripts of the interviews with student volunteers. Students were found to not have developed a mechanistic understanding of how the interaction between a reaction system (reactants or starting material(s), reagent(s), and/or solvent), experimental variables (pH, temperature, concentrations, etc), provides a result of interest (yield, selectivity, purity, etc.) for an experiment performed in the organic chemistry laboratory. However, students' prior exposure to and understanding of chemical concepts was found to simultaneously assist and hinder in their development of a partial mechanistic understanding of how a reaction system (reactants or starting material(s), reagent(s), and/or solvent), experimental variables (pH, temperature, concentrations, etc), interact to provide a result of interest (yield

  19. A laboratory module on radiometry, photometry and colorimetry for an undergraduate optics course

    NASA Astrophysics Data System (ADS)

    Polak, Robert D.

    2014-07-01

    The bachelor's degree in Physics at Loyola University Chicago requires both an upper-division course in Optics as well as a companion Optics Laboratory course. Recently, the laboratory course has undergone dramatic changes. Traditional weekly laboratories have been replaced with three laboratory modules, where students focus on a single topic over several weeks after which the students submit a laboratory report written in the style of a journal article following American Institute of Physics style manual. With this method, students are able to gain a deeper understanding of the specific topic areas of radiometry, photometry and colorimetry, lens design and aberrations, and polarization and interference while using industry-standard equipment and simulation software. In particular, this work will provide the details of the laboratory module on radiometry, photometry and colorimetry where students use a photoradiometer and integrating sphere to characterize the optical properties of an LCD monitor, light bulb and a fiber optic light source calculating properties such as luminous flux, luminous intensity, luminance, CIE color coordinates, NTSC ratio, color temperature and luminous efficacy.

  20. A Solvent-Free Baeyer-Villiger Lactonization for the Undergraduate Organic Laboratory: Synthesis of Gamma-T-Butyl-Epsilon-Caprolactone

    ERIC Educational Resources Information Center

    Esteb, John J.; Hohman, Nathan J.; Schlamandinger, Diana E.; Wilson, Anne M.

    2005-01-01

    The solvent-free or solid-state reaction systems like the Baeyer-Villiger rearrangement have become popular in the synthetic organic community and viable option for undergraduate laboratory series to reduce waste and cost and simplify reaction process. The reaction is an efficient method to transform ketones to esters and lactones.

  1. Argument-Driven Inquiry: Using the Laboratory to Improve Undergraduates' Science Writing Skills through Meaningful Science Writing, Peer-Review, and Revision

    ERIC Educational Resources Information Center

    Walker, Joi Phelps; Sampson, Victor

    2013-01-01

    This paper presents preliminary evidence supporting the use of peer review in undergraduate science as a means to improve student writing and to alleviate barriers, such as lost class time, by incorporation of the peer-review process into the laboratory component of the course. The study was conducted in a single section of an undergraduate…

  2. A Research-Based Undergraduate Organic Laboratory Project: Investigation of a One-Pot, Multicomponent, Environmentally Friendly Prins-Friedel-Crafts-Type Reaction

    ERIC Educational Resources Information Center

    Dintzner, Matthew R.; Maresh, Justin J.; Kinzie, Charles R.; Arena, Anthony F.; Speltz, Thomas

    2012-01-01

    Students in the undergraduate organic laboratory synthesize tetrahydro-2-(4-nitrophenyl)-4-phenyl-2"H"-pyran via the Montmorillonite K10 clay-catalyzed reaction of p-nitrobenzaldehye with methanol, 3-buten-1-ol, and benzene. The synthesis comprises an environmentally friendly tandem Prins-Friedel-Crafts-type multicomponent reaction (MCR) and sets…

  3. A Simplified Undergraduate Laboratory Experiment to Evaluate the Effect of the Ionic Strength on the Equilibrium Concentration Quotient of the Bromcresol Green Dye

    ERIC Educational Resources Information Center

    Rodriguez, Hernan B.; Mirenda, Martin

    2012-01-01

    A modified laboratory experiment for undergraduate students is presented to evaluate the effects of the ionic strength, "I", on the equilibrium concentration quotient, K[subscript c], of the acid-base indicator bromcresol green (BCG). The two-step deprotonation of the acidic form of the dye (sultone form), as it is dissolved in water, yields…

  4. An Inexpensive, Relatively Green, and Rapid Method to Purify Genomic DNA from "Escherichia Coli": An Experiment for the Undergraduate Biochemistry Laboratory

    ERIC Educational Resources Information Center

    Sims, Paul A.; Branscum, Katie M.; Kao, Lydia; Keaveny, Virginia R.

    2010-01-01

    A method to purify genomic DNA from "Escherichia coli" is presented. The method is an amalgam of published methods but has been modified and optimized for use in the undergraduate biochemistry laboratory. Specifically, the method uses Tide Free 2x Ultra laundry detergent, which contains unspecified proteases and lipases, "n"-butanol, 2-propanol,…

  5. Virtual and Traditional Slides for Teaching Cellular Morphology to Medical Laboratory Science Undergraduates: A Comparative Study of Performance Outcomes, Retention, and Self-Efficacy Beliefs

    ERIC Educational Resources Information Center

    Solberg, Brooke L.

    2011-01-01

    As a result of massive retirement and educational program expense and closure, the field of Medical Laboratory Science (MLS) is facing a critical workforce shortage. Combatting this issue by increasing undergraduate class size is a difficult proposition due to the intense psychomotor curricular requirements of MLS programs. Technological advances…

  6. Ligand-Free Suzuki-Miyaura Coupling Reactions Using an Inexpensive Aqueous Palladium Source: A Synthetic and Computational Exercise for the Undergraduate Organic Chemistry Laboratory

    ERIC Educational Resources Information Center

    Hill, Nicholas J.; Bowman, Matthew D.; Esselman, Brian J.; Byron, Stephen D.; Kreitinger, Jordan; Leadbeater, Nicholas E.

    2014-01-01

    An inexpensive procedure for introducing the Suzuki-Miyaura coupling reaction into a high-enrollment undergraduate organic chemistry laboratory course is described. The procedure employs an aqueous palladium solution as the catalyst and a range of para-substituted aryl bromides and arylboronic acids as substrates. The coupling reactions proceed…

  7. A Western Blot-based Investigation of the Yeast Secretory Pathway Designed for an Intermediate-Level Undergraduate Cell Biology Laboratory

    ERIC Educational Resources Information Center

    Hood-DeGrenier, Jennifer K.

    2008-01-01

    The movement of newly synthesized proteins through the endomembrane system of eukaryotic cells, often referred to generally as the secretory pathway, is a topic covered in most intermediate-level undergraduate cell biology courses. An article previously published in this journal described a laboratory exercise in which yeast mutants defective in…

  8. Synthesis and Characterization of Aldol Condensation Products from Unknown Aldehydes and Ketones: An Inquiry-Based Experiment in the Undergraduate Laboratory

    ERIC Educational Resources Information Center

    Angelo, Nicholas G.; Henchey, Laura K.; Waxman, Adam J.; Canary, James W.; Arora, Paramjit S.; Wink, Donald

    2007-01-01

    An experiment for the undergraduate chemistry laboratory in which students perform the aldol condensation on an unknown aldehyde and an unknown ketone is described. The experiment involves the use of techniques such as TLC, column chromatography, and recrystallization, and compounds are characterized by [to the first power]H NMR, GC-MS, and FTIR.…

  9. Preparation of a Cobalt(II) Cage: An Undergraduate Laboratory Experiment That Produces a ParaSHIFT Agent for Magnetic Resonance Spectroscopy

    ERIC Educational Resources Information Center

    Burns, Patrick J.; Tsitovich, Pavel B.; Morrow, Janet R.

    2016-01-01

    Laboratory experiments that demonstrate the effect of paramagnetic complexes on chemical shifts and relaxation times of protons are a useful way to introduce magnetic resonance spectroscopy (MRS) probes or magnetic resonance imaging (MRI) contrast agents. In this undergraduate inorganic chemistry experiment, a paramagnetic Co(II) cage complex is…

  10. Volumetric Titrations Using Electrolytically Generated Reagents for the Determination of Ascorbic Acid and Iron in Dietary Supplement Tablets: An Undergraduate Laboratory Experiment

    ERIC Educational Resources Information Center

    Scanlon, Christopher; Gebeyehu, Zewdu; Griffin, Kameron; Dabke, Rajeev B.

    2014-01-01

    An undergraduate laboratory experiment for the volumetric quantitative analysis of ascorbic acid and iron in dietary supplement tablets is presented. Powdered samples of the dietary supplement tablets were volumetrically titrated against electrolytically generated reagents, and the mass of dietary reagent in the tablet was determined from the…

  11. Using Mole Ratios of Electrolytic Products of Water for Analysis of Household Vinegar: An Experiment for the Undergraduate Physical Chemistry Laboratory

    ERIC Educational Resources Information Center

    Dabke, Rajeev B.; Gebeyehu, Zewdu

    2012-01-01

    A simple 3-h physical chemistry undergraduate experiment for the quantitative analysis of acetic acid in household vinegar is presented. The laboratory experiment combines titration concept with electrolysis and an application of the gas laws. A vinegar sample was placed in the cathode compartment of the electrolysis cell. Electrolysis of water…

  12. STRUCTURED LEARNING AND TRAINING ENVIRONMENTS--A PREPARATION LABORATORY FOR ADVANCED MAMMALIAN PHYSIOLOGY.

    ERIC Educational Resources Information Center

    FIEL, NICHOLAS J.; JOHNSTON, RAYMOND F.

    A PREPARATION LABORATORY WAS DESIGNED TO FAMILIARIZE STUDENTS IN ADVANCED MAMMALIAN PHYSIOLOGY WITH LABORATORY SKILLS AND TECHNIQUES AND THUS SHORTEN THE TIME THEY SPEND IN SETTING UP ACTUAL EXPERIMENTS. THE LABORATORY LASTS 30 MINUTES, IS FLEXIBLE AND SIMPLE OF OPERATION, AND DOES NOT REQUIRE A PROFESSOR'S PRESENCE. THE BASIC TRAINING UNIT IS THE…

  13. The Miracle Fruit: An Undergraduate Laboratory Exercise in Taste Sensation and Perception.

    PubMed

    Lipatova, Olga; Campolattaro, Matthew M

    2016-01-01

    "Miracle Fruit" is a taste-altering berry that causes sour foods to be perceived as sweet. The present paper describes a laboratory exercise that uses Miracle Fruit to educate students about the sensation and perception of taste. This laboratory exercise reinforces course material pertaining to the function of sweet taste receptors covered in a Sensation and Perception course at Christopher Newport University. Here we provide a step-by-step explanation of the methodology, and an example of data collected and analyzed by one group of students who participated in this laboratory exercise. The origins of the Miracle Fruit, the structure and the physiological function of miraculin (the glycoprotein responsible for the taste-modifying effect found in the pulp of the Miracle Fruit) were discussed before the laboratory exercise. Students then sampled foods known to target different types of tastes (i.e., sweet, sour, bitter and salty) and rated their perception of taste intensity for each food item. Next, students each consumed Miracle Fruit berries, then resampled each original food item and again recorded their perception of taste intensity ratings for these foods. The data confirmed that the sour food items were perceived sweeter after the Miracle Fruit was consumed. The students also completed a written assignment to assess what they learned about the origins, structure, and physiological function of Miracle Fruit. This hands-on laboratory exercise received positive feedback from students. The exercise can be used by other neuroscience educators to teach concepts related to the sensory system of taste.

  14. Conducting Reflective, Hands-On Research with Advanced Characterization Instruments: A High-Level Undergraduate Practical Exploring Solid-State Polymorphism

    ERIC Educational Resources Information Center

    Coles, S. J.; Mapp, L. K.

    2016-01-01

    An undergraduate practical exercise has been designed to provide hands-on, instrument-based experience of advanced characterization techniques. A research experience approach is taken, centered around the concept of solid-state polymorphism, which requires a detailed knowledge of molecular and crystal structure to be gained by advanced analytical…

  15. Changing undergraduate human anatomy and physiology laboratories: perspectives from a large-enrollment course.

    PubMed

    Griff, Edwin R

    2016-09-01

    In the present article, a veteran lecturer of human anatomy and physiology taught several sections of the laboratory component for the first time and shares his observations and analysis from this unique perspective. The article discusses a large-enrollment, content-heavy anatomy and physiology course in relationship to published studies on learning and student self-efficacy. Changes in the laboratory component that could increase student learning are proposed. The author also points out the need for research to assess whether selective curricular changes could increase the depth of understanding and retention of learned material.

  16. The Role of the State Health Laboratories in Advancing Health Equity.

    PubMed

    King, Ewa; Vanner, Cynthia; Leibovitz, Henry; Smith, Robin

    2016-11-01

    While laboratories play an important and recognized role in many public health programs that require surveillance of disease spread or monitoring of environmental conditions, the role of public laboratories in assessing and advancing health equity is not well understood. Yet, public laboratories collect, provide or generate much of the data used to determine health equity status and monitor heath equity trends in multiple settings and disciplines. RI State Health Laboratories, a division of the RI Department of Health, operates programs that help measure and address health disparities. Health equity themes are present in laboratory programs that measure environmental determinants of health and assure equal access to laboratory screening and diagnostic services. This article will review the role of laboratory programs in advancing health equity in the state. Specific examples of laboratory contributions to health equity programs will be provided and examined. Future trends and unmet needs will also be discussed. [Full article available at http://rimed.org/rimedicaljournal-2016-11.asp].

  17. Pure Rotational Spectroscopy of Asymmetric Tops in the Undergraduate Classroom or Laboratory

    NASA Astrophysics Data System (ADS)

    Minei, A. J.; Cooke, S. A.

    2013-06-01

    Due to concerns of complexity, the asymmetric top, for which κ = {(2B - A - C) / (A - C)} ≠ ± 1, is feared, or at least avoided, by many instructors when explaining the rigid rotor. However, the spectral patterns formed by cold} asymmetric rigid rotors in the centimeter-wave} region of the electromagnetic spectrum can be easily identified. We will present some techniques for spectral analyses that we have successfully employed with undergraduate students who are either ``pre-quantum mechanics" or are currently enrolled in a chemical quantum mechanics class. The activities are simple, requiring the students to first locate repeating patterns and then apply simple algebraic expressions in order to determine all three rotational constants. The method will be illustrated using the spectra of 2,2,3,3-tetrafluoropropyl trifluoroacetate (CF_3C(=O)OCH_2CF_2CHF_2), (E)-1,3,3,3-tetrafluoropropene (CF_3CH=CHF), 1H,1H,2H-perfluorocyclobutane (CF_2CF_2CHFCH_2), and 2H-nonafluorobutane (CF_3CHFCF_2CF_3). The first two of these species have predominantly a-type spectra, the third has a predominantly b-type spectrum, the fourth has a predominantly c-type spectrum.

  18. Characterizing Mystery Cell Lines: Student-driven Research Projects in an Undergraduate Neuroscience Laboratory Course.

    PubMed

    Lemons, Michele L

    2012-01-01

    Inquiry-based projects promote discovery and retention of key concepts, increase student engagement, and stimulate interest in research. Described here are a series of lab exercises within an undergraduate upper level neuroscience course that train students to design, execute and analyze their own hypothesis-driven research project. Prior to developing their own projects, students learn several research techniques including aseptic cell culture, cell line maintenance, immunocytochemistry and fluorescent microscopy. Working in groups, students choose how to use these techniques to characterize and identify a "mystery" cell line. Each lab group is given a unique cell line with either a neural, astrocyte, or Schwann cell origin. Working together, students plan and execute experiments to determine the cellular origin and other unique characteristics of their mystery cell line. Students generate testable hypotheses, design interpretable experiments, generate and analyze data, and report their findings in both oral and written formats. Students receive instructor and peer feedback throughout the entire project. In summary, these labs train students the process of scientific research. This series of lab exercises received very strong positive feedback from the students. Reflections on student feedback and plans for future improvements are discussed.

  19. Remediation of Water Contaminated with an Azo Dye: An Undergraduate Laboratory Experiment Utilizing an Inexpensive Photocatalytic Reactor

    NASA Astrophysics Data System (ADS)

    Bumpus, John A.; Tricker, Jennifer; Andrzejewski, Ken; Rhoads, Heather; Tatarko, Matthew

    1999-12-01

    The construction and use of an inexpensive photocatalytic reactor that utilizes titanium dioxide as the photocatalyst for wastewater treatment is described. In these experiments and in supplementary material, students are made aware that a variety of techniques have been developed to treat wastewaters, including those generated by the chemical industry. Water contaminated with the azo dye Congo Red was selected as an example of how one might treat contaminated water from a textile manufacturing facility. These experiments emphasize that, in addition to product development, chemists must also be concerned with waste treatment. A summary of the theory of titanium dioxide-mediated photocatalysis is provided. The phenomenon of photosensitization is also discussed. The usefulness of Congo Red is summarized and a brief history of this dye is given. In addition to being inexpensive, the photocatalytic reactor described is easy to construct and uses a readily available low-wattage fluorescent light. An important feature of this reactor is that the heat generated by the light source is readily dissipated by the water undergoing treatment. Thus no special cooling apparatus is required. One of the most important aspects of this work is that it provides a wide variety of continuing research suggestions that would be suitable and readily accomplished in undergraduate departments and high school laboratories; even those where budgetary priorities are a major concern. Use of this reactor would also enable students to design systems to treat "real-world" wastes, including some that are generated in instructional laboratories.

  20. Computer Based Learning in an Undergraduate Physics Laboratory: Interfacing and Instrument Control Using Matlab

    ERIC Educational Resources Information Center

    Sharp, J. S.; Glover, P. M.; Moseley, W.

    2007-01-01

    In this paper we describe the recent changes to the curriculum of the second year practical laboratory course in the School of Physics and Astronomy at the University of Nottingham. In particular, we describe how Matlab has been implemented as a teaching tool and discuss both its pedagogical advantages and disadvantages in teaching undergraduate…

  1. Gravimetric Analysis of Bismuth in Bismuth Subsalicylate Tablets: A Versatile Quantitative Experiment for Undergraduate Laboratories

    ERIC Educational Resources Information Center

    Davis, Eric; Cheung, Ken; Pauls, Steve; Dick, Jonathan; Roth, Elijah; Zalewski, Nicole; Veldhuizen, Christopher; Coeler, Joel

    2015-01-01

    In this laboratory experiment, lower- and upper-division students dissolved bismuth subsalicylate tablets in acid and precipitated the resultant Bi[superscript 3+] in solution with sodium phosphate for a gravimetric determination of bismuth subsalicylate in the tablets. With a labeled concentration of 262 mg/tablet, the combined data from three…

  2. An Undergraduate Organic Laboratory Project Involving Independent Synthesis of Novel Flavones.

    ERIC Educational Resources Information Center

    Letcher, R. M.

    1980-01-01

    Describes a synthetic organic laboratory experiment which ensures independence of students but is not excessively demanding of instructor time. Each student is provided with different starting materials to prepare different flavones but use the same general procedure, the "organic synthesis" flavone preparation. Various features of this procedure…

  3. Solid-Liquid and Liquid-Liquid Mixing Laboratory for Chemical Engineering Undergraduates

    ERIC Educational Resources Information Center

    Pour, Sanaz Barar; Norca, Gregory Benoit; Fradette, Louis; Legros, Robert; Tanguy, Philippe A.

    2007-01-01

    Solid-liquid and liquid-liquid mixing experiments have been developed to provide students with a practical experience on suspension and emulsification processes. The laboratory focuses on the characterization of the process efficiency, specifically the influence of the main operating parameters and the effect of the impeller type. (Contains 2…

  4. An Undergraduate Biochemistry Laboratory Course with an Emphasis on a Research Experience

    ERIC Educational Resources Information Center

    Caspers, Mary Lou; Roberts-Kirchhoff, Elizabeth S.

    2003-01-01

    In their junior or senior year, biochemistry majors at the University of Detroit Mercy are required to take a two-credit biochemistry laboratory course. Five years ago, the format of this course was changed from structured experiments to a more project-based approach. Several structured experiments were included at the beginning of the course…

  5. Individualizing Instruction in Large Undergraduate Biology Laboratories. II. Computers and Investigation

    ERIC Educational Resources Information Center

    Norberg, Ann Marie

    1975-01-01

    Describes the following uses of computers in college biology laboratories: (1) to organize and analyze research data and (2) to simulate biological systems. Also being developed are computer simulations to systematically prepare students for independent investigations. (See also SE 515 092.) (LS)

  6. Studying Epigenetic DNA Modifications in Undergraduate Laboratories Using Complementary Bioinformatic and Molecular Approaches

    ERIC Educational Resources Information Center

    Militello, Kevin T.

    2013-01-01

    Epigenetic inheritance is the inheritance of genetic information that is not based on DNA sequence alone. One type of epigenetic information that has come to the forefront in the last few years is modified DNA bases. The most common modified DNA base in nature is 5-methylcytosine. Herein, we describe a laboratory experiment that combines…

  7. Successful Implementation of Inquiry-Based Physiology Laboratories in Undergraduate Major and Nonmajor Courses

    ERIC Educational Resources Information Center

    Casotti, G.; Rieser-Danner, L.; Knabb, M. T.

    2008-01-01

    Recent evidence has demonstrated that inquiry-based physiology laboratories improve students' critical- and analytical-thinking skills. We implemented inquiry-based learning into three physiology courses: Comparative Vertebrate Physiology (majors), Human Physiology (majors), and Human Anatomy and Physiology (nonmajors). The aims of our curricular…

  8. Dehydration of 2-Methyl-1-Cyclohexanol: New Findings from a Popular Undergraduate Laboratory Experiment

    ERIC Educational Resources Information Center

    Friesen, J. Brent; Schretzman, Robert

    2011-01-01

    The mineral acid-catalyzed dehydration of 2-methyl-1-cyclohexanol has been a popular laboratory exercise in second-year organic chemistry for several decades. The dehydration experiment is often performed by organic chemistry students to illustrate Zaitsev's rule. However, sensitive analytical techniques reveal that the results do not entirely…

  9. Using the Polymerase Chain Reaction in an Undergraduate Laboratory to Produce "DNA Fingerprints."

    ERIC Educational Resources Information Center

    Phelps, Tara L.; And Others

    1996-01-01

    Presents a laboratory exercise that demonstrates the sensitivity of the Polymerase Chain Reaction as well as its potential application to forensic analysis during a criminal investigation. Can also be used to introduce, review, and integrate population and molecular genetics topics such as genotypes, multiple alleles, allelic and genotypic…

  10. Microfluidics Meets Dilute Solution Viscometry: An Undergraduate Laboratory to Determine Polymer Molecular Weight Using a Microviscometer

    ERIC Educational Resources Information Center

    Pety, Stephen J.; Lu, Hang; Thio, Yonathan S.

    2011-01-01

    This paper describes a student laboratory experiment to determine the molecular weight of a polymer sample by measuring the viscosity of dilute polymer solutions in a PDMS microfluidic viscometer. Sample data are given for aqueous solutions of poly(ethylene oxide) (PEO). A demonstration of shear thinning behavior using the microviscometer is…

  11. Reflective Practice: A Place in Enhancing Learning in the Undergraduate Bioscience Teaching Laboratory?

    ERIC Educational Resources Information Center

    Parry, Damian; Walsh, Cathy; Larsen, Carl; Hogan, Joanne

    2012-01-01

    Bioscience employers demand graduates with better practical competence. It is our supposition that, although undesirable, student learning is assessment driven and this is leading students to simply go through the motions in the practical setting (whether field work or laboratory based). In this intervention a Critical Incident Report was…

  12. A Metabolic Murder Mystery: A Case-Based Experiment for the Undergraduate Biochemistry Laboratory

    ERIC Educational Resources Information Center

    Childs-Disney, Jessica L.; Kauffmann, Andrew D.; Poplawski, Shane G.; Lysiak, Daniel R.; Stewart, Robert J.; Arcadi, Jane K.; Dinan, Frank J.

    2010-01-01

    In 1990, a woman was wrongly convicted of poisoning her infant son and was sentenced to life in prison. Her conviction was based on laboratory work that wrongly identified ethylene glycol as present in her son's blood and in the formula he drank prior to his death. The actual cause of the infant's death, a metabolic disease, was eventually…

  13. Biocatalyzed Regioselective Synthesis in Undergraduate Organic Laboratories: Multistep Synthesis of 2-Arachidonoylglycerol

    ERIC Educational Resources Information Center

    Johnston, Meghan R.; Makriyannis, Alexandros; Whitten, Kyle M.; Drew, Olivia C.; Best, Fiona A.

    2016-01-01

    In order to introduce the concepts of biocatalysis and its utility in synthesis to organic chemistry students, a multistep synthesis of endogenous cannabinergic ligand 2-arachidonoylglycerol (2-AG) was tailored for use as a laboratory exercise. Over four weeks, students successfully produced 2-AG, purifying and characterizing products at each…

  14. The Miracle Fruit: An Undergraduate Laboratory Exercise in Taste Sensation and Perception

    PubMed Central

    Lipatova, Olga; Campolattaro, Matthew M.

    2016-01-01

    “Miracle Fruit” is a taste-altering berry that causes sour foods to be perceived as sweet. The present paper describes a laboratory exercise that uses Miracle Fruit to educate students about the sensation and perception of taste. This laboratory exercise reinforces course material pertaining to the function of sweet taste receptors covered in a Sensation and Perception course at Christopher Newport University. Here we provide a step-by-step explanation of the methodology, and an example of data collected and analyzed by one group of students who participated in this laboratory exercise. The origins of the Miracle Fruit, the structure and the physiological function of miraculin (the glycoprotein responsible for the taste-modifying effect found in the pulp of the Miracle Fruit) were discussed before the laboratory exercise. Students then sampled foods known to target different types of tastes (i.e., sweet, sour, bitter and salty) and rated their perception of taste intensity for each food item. Next, students each consumed Miracle Fruit berries, then resampled each original food item and again recorded their perception of taste intensity ratings for these foods. The data confirmed that the sour food items were perceived sweeter after the Miracle Fruit was consumed. The students also completed a written assignment to assess what they learned about the origins, structure, and physiological function of Miracle Fruit. This hands-on laboratory exercise received positive feedback from students. The exercise can be used by other neuroscience educators to teach concepts related to the sensory system of taste. PMID:27980471

  15. Climate-Literacy Laboratory Exercises for Undergraduate Students in an Introductory Weather and Climate Course

    NASA Astrophysics Data System (ADS)

    Diem, J.; Elliott, W.; Criswell, B.; Morrow, C. A.

    2012-12-01

    A suite of NASA-sponsored, Web-based exercises are in development for an introductory weather and climate course at Georgia State University (GSU) to improve climate literacy among undergraduate students. An extremely small percentage of the students are STEM majors. The exercises make extensive use of NASA resources and are guided in part by the concepts in Climate Literacy: The Essential Principles of Climate Science. At least two thousand undergraduate students have completed a majority of the exercises over the past two years. Nine of the twelve exercises in the course are connected strongly to climate literacy. The topics of those nine exercises are as follows: (1) Solar Irradiance, (2) Stratospheric Ozone, (3) Tropospheric Air, (4) The Carbon Cycle, (5) Global Surface Temperature, (6) Glacial-Interglacial Cycles, (7) Temperature Changes during the Past Millennium, (8) Climate & Ecosystems, and (9) Current & Future Climate Change. Two of the exercises (Tropospheric Air and The Carbon Cycle) make use of carbon dioxide (CO2) measurements made by students themselves and by a stationary CO2 monitor at GSU. The three remaining exercises, The Hadley Cell, Atlanta Weather, and Air Pollution, are less connected to multiple climate-literacy concepts; nonetheless, they provide a more complete experience for the students in the understanding of climate processes, differences between weather and climate, and human impacts on the atmosphere. All exercises are based on an inquiry-based learning cycle (i.e. 7 Es) and require substantial amounts of engagement, applied thinking, and critical thinking by the students. Not only do students become knowledgeable about the essential principles of climate change, especially global warming, but extensive use of geographical-information software and hand-held measurement devices has provided students with training in geography and technology. Student attitudes towards the labs were gathered via an on-line, anonymous survey from

  16. Advanced Combustion and Fuels; NREL (National Renewable Energy Laboratory)

    SciTech Connect

    Zigler, Brad

    2015-06-08

    Presented at the U.S. Department of Energy Vehicle Technologies Office 2015 Annual Merit Review and Peer Evaluation Meeting, held June 8-12, 2015, in Arlington, Virginia. It addresses technical barriers of inadequate data and predictive tools for fuel and lubricant effects on advanced combustion engines, with the strategy being through collaboration, develop techniques, tools, and data to quantify critical fuel physico-chemical effects to enable development of advanced combustion engines that use alternative fuels.

  17. The effectiveness and user perception of 3-dimensional digital human anatomy in an online undergraduate anatomy laboratory

    NASA Astrophysics Data System (ADS)

    Hilbelink, Amy Joanne

    2007-12-01

    The primary purpose of this study was to determine the effectiveness of implementing desktop 3-dimensional (3D) stereo images of human anatomy into an undergraduate human anatomy distance laboratory. User perceptions of 2D and 3D images were gathered via questionnaire in order to determine ease of use and level of satisfaction associated with the 3D software in the online learning environment. Mayer's (2001, p. 184) principles of design were used to develop the study materials that consisted of PowerPoint presentations and AVI files accessed via Blackboard. The research design employed a mixed-methods approach. Volunteers each were administered a demographic survey and were then stratified into groups based upon pre-test scores. A total sample size of 62 pairs was available for combined data analysis. Quantitative research questions regarding the effectiveness of 2D versus the 3D treatment were analyzed using a doubly-multivariate repeated measures (Doubly-MANOVA) design. Paired test scores achieved by undergraduates on a laboratory practical of identification and spatial relationships of the bones and features of a human skull were used in the analysis. The questionnaire designed to gather user perceptions consisted of quantitative and qualitative questions. Response frequencies were analyzed for the two groups and common themes were noted. Results revealed a statistically significant difference in group means for the main effect of the treatment groups 2D and 3D and for the variables of identification and relationship with the 3D group outperforming the 2D group on both dependent variables. Effect sizes were determined to be small, 0.215 for the identification variable and 0.359 for the relationship variable. Overall, all students liked the convenience of using PowerPoint and AVI files online. The 3D group felt their PowerPoint was more realistic than did the 2D group and both groups appreciated the detailed labeling of the online images. One third of the

  18. Solvent-Free Synthesis and Fluorescence of a Thiol-Reactive Sensor for Undergraduate Organic Laboratories.

    PubMed

    Patterson, Anastasia L; May, Mary D; Visser, Bryan J; Kislukhin, Alexander A; Vosburg, David A

    2013-12-10

    A green organic laboratory experiment was developed in which students synthesize a sensor for thiols using a microscale, solventless Diels-Alder reaction at room temperature or 37 °C. The molecular probe is easily purified by column chromatography in a Pasteur pipet and characterized by thin-layer chromatography and NMR spectroscopy. The thiol-reactive sensor becomes intensely fluorescent upon exposure to thiols from N-acetylcysteine, bovine serum albumin, or human hair (pretreated with a reducing agent to reveal cysteine thiols in α-keratin). This fluorescence is observable even with micrograms of probe.

  19. Solvent-Free Synthesis and Fluorescence of a Thiol-Reactive Sensor for Undergraduate Organic Laboratories

    PubMed Central

    Patterson, Anastasia L.; May, Mary D.; Visser, Bryan J.; Kislukhin, Alexander A.; Vosburg, David A.

    2013-01-01

    A green organic laboratory experiment was developed in which students synthesize a sensor for thiols using a microscale, solventless Diels–Alder reaction at room temperature or 37 °C. The molecular probe is easily purified by column chromatography in a Pasteur pipet and characterized by thin-layer chromatography and NMR spectroscopy. The thiol-reactive sensor becomes intensely fluorescent upon exposure to thiols from N-acetylcysteine, bovine serum albumin, or human hair (pretreated with a reducing agent to reveal cysteine thiols in α-keratin). This fluorescence is observable even with micrograms of probe. PMID:24415795

  20. Can Random Mutation Mimic Design?: A Guided Inquiry Laboratory for Undergraduate Students

    PubMed Central

    Kalinowski, Steven T.; Taper, Mark L.; Metz, Anneke M.

    2006-01-01

    Complex biological structures, such as the human eye, have been interpreted as evidence for a creator for over three centuries. This raises the question of whether random mutation can create such adaptations. In this article, we present an inquiry-based laboratory experiment that explores this question using paper airplanes as a model organism. The main task for students in this investigation is to figure out how to simulate paper airplane evolution (including reproduction, inheritance, mutation, and selection). In addition, the lab requires students to practice analytic thinking and to carefully delineate the implications of their results. PMID:16951065

  1. Conformational Analysis in an Advanced Integrated Laboratory Course

    ERIC Educational Resources Information Center

    Ball, David B.; Miller, Randy M.

    2004-01-01

    A series of sophisticated, combined laboratory experiments are developed involving the use of various spectroscopic and other techniques in the conformational analysis of cyclohexane mechanisms. The multi-system approach enables the students to transcend the one-dimensional procedure, and develops their synthetic and diagnostic skills.

  2. A Simple Photochemical Experiment for the Advanced Laboratory.

    ERIC Educational Resources Information Center

    Rosenfeld, Stuart M.

    1986-01-01

    Describes an experiment to provide students with: (1) an introduction to photochemical techniques and theory; (2) an experience with semimicro techniques; (3) an application of carbon-14 nuclear magnetic resonance; and (4) a laboratory with some qualities of a genuine experiment. These criteria are met in the photooxidation of 9,…

  3. Nobel Chemistry in the Laboratory: Synthesis of a Ruthenium Catalyst for Ring-Closing Olefin Metathesis--An Experiment for the Advanced Inorganic or Organic Laboratory

    ERIC Educational Resources Information Center

    Greco, George E.

    2007-01-01

    An experiment for the upper-level undergraduate laboratory is described in which students synthesize a ruthenium olefin metathesis catalyst, then use the catalyst to carry out the ring-closing metathesis of diethyl diallylmalonate. The olefin metathesis reaction was the subject of the 2005 Nobel Prize in chemistry. The catalyst chosen for this…

  4. Demonstrating Chemical and Analytical Concepts in the Undergraduate Laboratory Using Capillary Electrophoresis and Micellar Electrokinetic Chromatography

    NASA Astrophysics Data System (ADS)

    Palmer, Christopher P.

    1999-11-01

    This paper describes instrumental analysis laboratory exercises that utilize capillary electrophoresis and micellar electrokinetic chromatography to demonstrate several analytical and chemical principles. Alkyl parabens (4-hydroxy alkyl benzoates), which are common ingredients in cosmetic formulations, are separated by capillary electrophoresis. The electrophoretic mobilities of the parabens can be explained on the basis of their relative size. 3-Hydroxy ethylbenzoate is also separated to demonstrate the effect of substituent position on the acid dissociation constant and the effect this has on electrophoretic mobility. Homologous series of alkyl benzoates and alkyl phthalates (common plasticizers) are separated by micellar electrokinetic chromatography at four surfactant concentrations. This exercise demonstrates the separation mechanism of micellar electrokinetic chromatography, the concept of chromatographic phase ratio, and the concepts of micelle formation. A photodiode array detector is used in both exercises to demonstrate the advantages and limitations of the detector and to demonstrate the effect of pH and substituent position on the spectra of the analytes.

  5. Engaging Undergraduates in Social Science Research: The Taking the Pulse of Saskatchewan Project

    ERIC Educational Resources Information Center

    Berdahl, Loleen

    2014-01-01

    Although student involvement in research and inquiry can advance undergraduate learning, there are limited opportunities for undergraduate students to be directly involved in social science research. Social science faculty members typically work outside of laboratory settings, with the limited research assistance work being completed by graduate…

  6. Use of the Herb Gymnema sylvestre to Illustrate the Principles of Gustatory Sensation: An Undergraduate Neuroscience Laboratory Exercise.

    PubMed

    Schroeder, Joseph A; Flannery-Schroeder, Ellen

    2005-01-01

    The Indian herb Gymnema sylvestre has been used in traditional Ayurvedic medicine for 2000 years, most recently for the treatment of diabetes. Loose leaf Gymnema sylvestre can be prepared as a tea and will impair the ability to taste sugar by blocking sweet receptors on the tongue. This report describes a laboratory exercise easily applied to an undergraduate neuroscience course that can be used to illustrate the principles of gustatory sensation. Combined with a preceding lecture on the primary taste sensations, students experience and appreciate how the primary tastes are combined to produce overall taste. In addition, the exercises outlined here expand upon previously published demonstrations employing Gymnema sylvestre to include illustrations of the different sensory transduction mechanisms associated with each of the four or five primary taste modalities. Students compare their qualitative primary taste experiences to salt, sugar, aspartame, chocolate, and sweet-sour candy prior to and following exposure to Gymnema sylvestre. The herb's impairment of sweet sensation is profound and dramatically alters the perception of sweetness in sugar, chocolate, and candy without altering the perception of the other primary tastes. The exercise has an indelible effect on students because the herb's intense effect compels students to rely on their unique personal experiences to highlight the principles of gustatory sensation.

  7. Use of the Herb Gymnema sylvestre to Illustrate the Principles of Gustatory Sensation: An Undergraduate Neuroscience Laboratory Exercise

    PubMed Central

    Schroeder, Joseph A.; Flannery-Schroeder, Ellen

    2005-01-01

    The Indian herb Gymnema sylvestre has been used in traditional Ayurvedic medicine for 2000 years, most recently for the treatment of diabetes. Loose leaf Gymnema sylvestre can be prepared as a tea and will impair the ability to taste sugar by blocking sweet receptors on the tongue. This report describes a laboratory exercise easily applied to an undergraduate neuroscience course that can be used to illustrate the principles of gustatory sensation. Combined with a preceding lecture on the primary taste sensations, students experience and appreciate how the primary tastes are combined to produce overall taste. In addition, the exercises outlined here expand upon previously published demonstrations employing Gymnema sylvestre to include illustrations of the different sensory transduction mechanisms associated with each of the four or five primary taste modalities. Students compare their qualitative primary taste experiences to salt, sugar, aspartame, chocolate, and sweet-sour candy prior to and following exposure to Gymnema sylvestre. The herb’s impairment of sweet sensation is profound and dramatically alters the perception of sweetness in sugar, chocolate, and candy without altering the perception of the other primary tastes. The exercise has an indelible effect on students because the herb’s intense effect compels students to rely on their unique personal experiences to highlight the principles of gustatory sensation. PMID:23493970

  8. Student-Driven Engagement: An Interdisciplinary-Team Research-Learning Renewable Energy Laboratory Experience for Undergraduates

    NASA Astrophysics Data System (ADS)

    Tuominen, Mark

    How does engagement and deep learning happen? Every science department seeks to cultivate an excellent level of scientific skills and knowledge in its undergraduate students. Yet, this is not sufficient to thrive as a professional. Engaging directly in real-world challenges can foster a professional attitude: a high level of self-efficacy, a genuine sense of relevance, and proactivity. This talk will describe pedagogical developments of a junior-year renewable energy laboratory course at the University of Massachusetts Amherst that is part of a four-year Integrated Concentration in Science (iCons) program. Over the four years, the interdisciplinary iCons students-from 24 various majors-work through case studies, selection and analysis of real-world problems, inception and development of potential solutions, integrative communication, experimental practice, and capstone research. The team dynamic is a central aspect of the experience, yielding significant educational and developmental benefits. The third-year energy course uses adopts a culture of a small vibrant R and D company (I3E - ``Energy, Powered By Intelligence''), in which every person in the course has a vital responsibility and creative resourcefulness must be employed in the project work. The course emphasizes the practice of using reflection and redesign, as a means of generating better solutions and embedding the practice of learning in a real-world context. This work is supported in part by NSF Grant DUE-1140805.

  9. Advanced Benchmarking for Complex Building Types: Laboratories as an Exemplar

    SciTech Connect

    Mathew, Paul A.; Clear, Robert; Kircher, Kevin; Webster, Tom; Lee, Kwang Ho; Hoyt, Tyler

    2010-08-01

    Complex buildings such as laboratories, data centers and cleanrooms present particular challenges for energy benchmarking because it is difficult to normalize special requirements such as health and safety in laboratories and reliability (i.e., system redundancy to maintain uptime) in data centers which significantly impact energy use. For example, air change requirements vary widely based on the type of work being performed in each laboratory space. We present methods and tools for energy benchmarking in laboratories, as an exemplar of a complex building type. First, we address whole building energy metrics and normalization parameters. We present empirical methods based on simple data filtering as well as multivariate regression analysis on the Labs21 database. The regression analysis showed lab type, lab-area ratio and occupancy hours to be significant variables. Yet the dataset did not allow analysis of factors such as plug loads and air change rates, both of which are critical to lab energy use. The simulation-based method uses an EnergyPlus model to generate a benchmark energy intensity normalized for a wider range of parameters. We suggest that both these methods have complementary strengths and limitations. Second, we present"action-oriented" benchmarking, which extends whole-building benchmarking by utilizing system-level features and metrics such as airflow W/cfm to quickly identify a list of potential efficiency actions which can then be used as the basis for a more detailed audit. While action-oriented benchmarking is not an"audit in a box" and is not intended to provide the same degree of accuracy afforded by an energy audit, we demonstrate how it can be used to focus and prioritize audit activity and track performance at the system level. We conclude with key principles that are more broadly applicable to other complex building types.

  10. An Undergraduate Laboratory Exercise that Demonstrates the Difference Between Peripherally and Centrally Mediated Measures

    PubMed Central

    Lowe, Sam; Tommerdahl, Anna; Lensch, Rachael; Francisco, Eric; Holden, Jameson; Tommerdahl, Mark

    2016-01-01

    One of the first concepts that students of neuroscience are exposed to is the overall organization of the nervous system and the two principle divisions of it: the Peripheral Nervous System (PNS) and the Central Nervous System (CNS). In sensory systems, this fundamental division plays a particularly prominent role in the information processing stream that integrates and processes information from the external environment to the CNS. To better understand the differences between the roles that the PNS and CNS play in information processing, we developed a relatively simple in-class laboratory exercise. The experimental methods used to determine several aspects of a subject’s discriminative capacity (threshold detection, amplitude discrimination, duration discrimination) are described. These methods were used either under control conditions or after the students altered their skin sensitivity (i.e., the PNS) by cold water immersion. At the conclusion of the lab exercise, students will thoroughly understand the principle of the PNS vs. CNS, as well as a fundamental understanding of quantitative sensory testing. This fundamental understanding of sensory testing provides a foundation for students to pursue or investigate other aspects of sensory information processing in either independent studies or subsequent lab exercises. PMID:27980467

  11. Final Report - Advanced Ion Trap Mass Spectrometry Program - Oak Ridge National Laboratory - Sandia National Laboratory

    SciTech Connect

    Whitten, W.B.

    2002-12-18

    This report covers the three main projects that collectively comprised the Advanced Ion Trap Mass Spectrometry Program. Chapter 1 describes the direct interrogation of individual particles by laser desorption within the ion trap mass spectrometer analyzer. The goals were (1) to develop an ''intelligent trigger'' capable of distinguishing particles of biological origin from those of nonbiological origin in the background and interferent particles and (2) to explore the capability for individual particle identification. Direct interrogation of particles by laser ablation and ion trap mass spectrometry was shown to have good promise for discriminating between particles of biological origin and those of nonbiological origin, although detailed protocols and operating conditions were not worked out. A library of more than 20,000 spectra of various types of biological particles has been assembled. Methods based on multivariate analysis and on neural networks were used to discriminate between particles of biological origin and those of nonbiological origin. It was possible to discriminate between at least some species of bacteria if mass spectra of several hundred similar particles were obtained. Chapter 2 addresses the development of a new ion trap mass analyzer geometry that offers the potential for a significant increase in ion storage capacity for a given set of analyzer operating conditions. This geometry may lead to the development of smaller, lower-power field-portable ion trap mass spectrometers while retaining laboratory-scale analytical performance. A novel ion trap mass spectrometer based on toroidal ion storage geometry has been developed. The analyzer geometry is based on the edge rotation of a quadrupolar ion trap cross section into the shape of a torus. Initial performance of this device was poor, however, due to the significant contribution of nonlinear fields introduced by the rotation of the symmetric ion-trapping geometry. These nonlinear resonances

  12. Integrating a Discovery-Based Laboratory to Teach Supply Chain Management Fundamentals in an Undergraduate Management Course

    ERIC Educational Resources Information Center

    Zeng, Amy; Johnson, Sharon

    2009-01-01

    Using experiential simulation games is a commonly used pedagogical method to enrich classroom discussions and to facilitate students' learning in supply chain management education at both undergraduate and graduate levels. However, existing games are inappropriate for undergraduate students that are first-time learners of the subject. In this…

  13. Sedimentation Coefficient, Frictional Coefficient, and Molecular Weight: A Preparative Ultracentrifuge Experiment for the Advanced Undergraduate Laboratory.

    ERIC Educational Resources Information Center

    Halsall, H. B.; Wermeling, J. R.

    1982-01-01

    Describes an experiment using a high-speed preparative centrifuge and calculator to demonstrate effects of the frictional coefficient of a macromolecule on its rate of transport in a force field and to estimate molecular weight of the macromolecule using an empirical relationship. Background information, procedures, and discussion of results are…

  14. Introduction to Homogenous Catalysis with Ruthenium-Catalyzed Oxidation of Alcohols: An Experiment for Undergraduate Advanced Inorganic Chemistry Students

    ERIC Educational Resources Information Center

    Miecznikowski, John R.; Caradonna, John P.; Foley, Kathleen M.; Kwiecien, Daniel J.; Lisi, George P.; Martinez, Anthony M.

    2011-01-01

    A three-week laboratory experiment, which introduces students in an advanced inorganic chemistry course to air-sensitive chemistry and catalysis, is described. During the first week, the students synthesize RuCl[subscript 2](PPh[subscript 3])[subscript 3]. During the second and third weeks, the students characterize the formed coordination…

  15. Advances in Laboratory Methods for Detection and Typing of Norovirus

    PubMed Central

    2014-01-01

    Human noroviruses are the leading cause of epidemic and sporadic gastroenteritis across all age groups. Although the disease is usually self-limiting, in the United States norovirus gastroenteritis causes an estimated 56,000 to 71,000 hospitalizations and 570 to 800 deaths each year. This minireview describes the latest data on laboratory methods (molecular, immunological) for norovirus detection, including real-time reverse transcription-quantitative PCR (RT-qPCR) and commercially available immunological assays as well as the latest FDA-cleared multi-gastrointestinal-pathogen platforms. In addition, an overview is provided on the latest nomenclature and molecular epidemiology of human noroviruses. PMID:24989606

  16. Advancing Materials Science using Neutrons at Oak Ridge National Laboratory

    ScienceCinema

    Carpenter, John

    2016-07-12

    Jack Carpenter, pioneer of accelerator-based pulsed spallation neutron sources, talks about neutron science at Oak Ridge National Laboratory (ORNL) and a need for a second target station at the Spallation Neutron Source (SNS). ORNL is the Department of Energy's largest multiprogram science and energy laboratory, and is home to two scientific user facilities serving the neutron science research community: the High Flux Isotope Reactor (HFIR) and SNS. HFIR and SNS provide researchers with unmatched capabilities for understanding the structure and properties of materials, macromolecular and biological systems, and the fundamental physics of the neutron. Neutrons provide a window through which to view materials at a microscopic level that allow researchers to develop better materials and better products. Neutrons enable us to understand materials we use in everyday life. Carpenter explains the need for another station to produce long wavelength neutrons, or cold neutrons, to answer questions that are addressed only with cold neutrons. The second target station is optimized for that purpose. Modern technology depends more and more upon intimate atomic knowledge of materials, and neutrons are an ideal probe.

  17. Brookhaven National Laboratory's capabilities for advanced analyses of cyber threats

    SciTech Connect

    DePhillips, M. P.

    2014-01-01

    BNL has several ongoing, mature, and successful programs and areas of core scientific expertise that readily could be modified to address problems facing national security and efforts by the IC related to securing our nation’s computer networks. In supporting these programs, BNL houses an expansive, scalable infrastructure built exclusively for transporting, storing, and analyzing large disparate data-sets. Our ongoing research projects on various infrastructural issues in computer science undoubtedly would be relevant to national security. Furthermore, BNL frequently partners with researchers in academia and industry worldwide to foster unique and innovative ideas for expanding research opportunities and extending our insights. Because the basic science conducted at BNL is unique, such projects have led to advanced techniques, unlike any others, to support our mission of discovery. Many of them are modular techniques, thus making them ideal for abstraction and retrofitting to other uses including those facing national security, specifically the safety of the nation’s cyber space.

  18. Growing a Science Internship One Year at a Time: Updates to the Science Undergraduate Laboratory Internship Program D. Ortiz-Arias, A. Dominguez, A. Zwicker, S. Greco

    NASA Astrophysics Data System (ADS)

    Ortiz, Deedee; Dominguez, Arturo; Zwicker, Andrew; Greco, Shannon

    2016-10-01

    Between 1993-2014, the National Undergraduate Fellowship (NUF) program, sponsored by the DOE Office of Fusion Energy Sciences, provided summer research internships for outstanding undergraduate students from around the country. Since then, the NUF program was merged into the Science Undergraduate Laboratory Internship (SULI) program, sponsored by the DOE Office of Workforce Development for Teachers and Students. While there were many similarities between the two programs, the SULI program did not include the one-week introductory course in plasma physics or the opportunity for participants to present their summer research results at this meeting. In the past two years, working with representatives from both OFES and WDTS, we have again implemented some of the most important components of the NUF program. The week-long, introductory course in plasma physics is included and streamed live- especially important since most undergraduate physics students have not taken a plasma physics course before they begin their research. Students are again able to present their research to our community, a critical component of a full research experience and plans are underway to obtain additional funding to once again include universities as eligible host sites.

  19. Advancements toward matter-antimatter pair plasmas in the laboratory

    NASA Astrophysics Data System (ADS)

    Stenson, E. V.; Hergenhahn, U.; Niemann, H.; Paschkowski, N.; Sunn Pedersen, T.; Saitoh, H.; Stanja, J.; Stoneking, M. R.; Hugenschmidt, C.; Piochacz, C.; Vohburger, S.; Schweikhard, L.; Danielson, J. R.; Surko, C. M.

    2015-11-01

    APEX/PAX (A Positron Electron Experiment/Positron Accumulation Experiment) has as its overarching goal the creation and magnetic confinement of a laboratory electron-positron pair plasma, thereby enabling experimental investigations of a topic that has already been the subject of hundreds of analytical and computational studies. This goal involves several interdependent challenges: design and construction of a suitable magnetic confinement device, access to a sufficient number of sufficiently cool positrons, and refinement of methods for the transfer of the positrons (and an equal number of electrons) into the device. The latest results of the subprojects addressing these challenges will be summarized here. Highlights include efficient (40 percent) injection of the NEPOMUC (Neutron-Inducted Positron Source Munich) positron beam into the confinement region of a dipole magnetic field, characterization of the beam at energies from 5 eV to 1 keV, and hour-long electron plasma confinement in a high-field (2.3 Telsa) Penning-Malmberg trap. on behalf of the APEX/PAX team and collaborators.

  20. Advanced Undergraduate Computer Based Astronomy Lab. The Astrometric Binary Kruger 60.

    NASA Astrophysics Data System (ADS)

    Slovak, M. H.

    2002-12-01

    A challenging computer based lab for astronomy undergraduate students has been developed to determine the masses of the components of the visual binary system Kruger 60 = HD 239960 = BD+56 2783 using archival astrometric observations. The data consist of separations and position angles from 1898 to 1949 (Lippincott 1953; Van de Kamp 1967) of Kruger 60B relative to Kruger 60A covering a complete orbit. After reviewing Kepler's 3rd or Harmonic Law and Newton's revision, they analyze the data using Microsoft Excel to calculate a best fitting elliptical orbit to the relative orbit of Kruger 60B. The importance of deriving stellar masses from such binaries is emphasized by discussing the significance of mass in the role of stellar evolution. This lab is one in a series being designed to provide astronomy majors practical experience in mathematically modeling astronomical data.This research was supported in part by NASA LaSPACE LURA Grant LSU 3115-30-5199.

  1. Advanced robotic technologies for transfer at Sandia National Laboratories

    SciTech Connect

    Bennett, P.C.

    1994-10-01

    Hazardous operations which have in the past been completed by technicians are under increased scrutiny due to high costs and low productivity associated with providing protective clothing and environments. As a result, remote systems are needed to accomplish many hazardous materials handling tasks such as the clean-up of waste sites in which the exposure of personnel to radiation, chemical, explosive and other hazardous constituents is unacceptable. Computer models augmented by sensing, and structured, modular computing environments are proving effective in automating many unstructured hazardous tasks. Work at Sandia National Laboratories (SNL) has focused on applying flexible automation (robotics) to meet the needs of the U.S. Department of Energy (USDOE). Dismantling facilities, environmental remediation, and materials handling in changing, hazardous environments lead to many technical challenges. Computer planning, monitoring and operator assistance shorten training cycles, reduce errors, and speed execution of operations. Robotic systems that re-use well-understood generic technologies can be much better characterized than robotic systems developed for a particular application, leading to a more reliable and safer systems. Further safety in robotic operations results from use of environmental sensors and knowledge of the task and environment. Collision detection and avoidance is achieved from such sensor integration and model-based control. This paper discusses selected technologies developed at SNL for use within the USDOE complex that have been or are ready for transfer to government and industrial suppliers. These technologies include sensors, sub-systems, and the design philosophy applied to quickly integrate them into a working robotic system. This paper represents the work of many people at the Intelligent Systems and Robotics Center at SNL, to whom the credit belongs.

  2. Determination of the Absolute Stereochemistry of Secondary Alcohols: An Advanced Organic Chemistry Experiment for Undergraduate Students.

    ERIC Educational Resources Information Center

    Bandaranayake, Wickramasinghe M.

    1980-01-01

    Describes experiments which can be completed in five four-hour laboratory sessions, including two synthesis (alpha-phenylbutyric and alpha-phenylbutyric acid anhydride) and determining the absolute stereochemistry of secondary alcohols using the synthetic products. (JN)

  3. Stereospecificity of NAD+/NADH Reactions: A Project Experiment for Advanced Undergraduates.

    ERIC Educational Resources Information Center

    Lowrey, Jonathan S.; And Others

    1981-01-01

    Presents background information, materials needed, and experimental procedures to study enzymes dependent on pyridine nucleotide coenzymes (NAD/NADH). The experiments, suitable for advanced organic or biochemistry courses, require approximately 10-15 hours to complete. (SK)

  4. Partnership in Undergraduate Research Experience

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Practical laboratory and work experience has been helpful in reinforcing the undergraduate educational experience. With limited resources, individual organizations may struggle to give a student a well rounded opportunity. Most undergraduates work within internships or cooperative educational fram...

  5. The genetic drift inventory: a tool for measuring what advanced undergraduates have mastered about genetic drift.

    PubMed

    Price, Rebecca M; Andrews, Tessa C; McElhinny, Teresa L; Mead, Louise S; Abraham, Joel K; Thanukos, Anna; Perez, Kathryn E

    2014-01-01

    Understanding genetic drift is crucial for a comprehensive understanding of biology, yet it is difficult to learn because it combines the conceptual challenges of both evolution and randomness. To help assess strategies for teaching genetic drift, we have developed and evaluated the Genetic Drift Inventory (GeDI), a concept inventory that measures upper-division students' understanding of this concept. We used an iterative approach that included extensive interviews and field tests involving 1723 students across five different undergraduate campuses. The GeDI consists of 22 agree-disagree statements that assess four key concepts and six misconceptions. Student scores ranged from 4/22 to 22/22. Statements ranged in mean difficulty from 0.29 to 0.80 and in discrimination from 0.09 to 0.46. The internal consistency, as measured with Cronbach's alpha, ranged from 0.58 to 0.88 across five iterations. Test-retest analysis resulted in a coefficient of stability of 0.82. The true-false format means that the GeDI can test how well students grasp key concepts central to understanding genetic drift, while simultaneously testing for the presence of misconceptions that indicate an incomplete understanding of genetic drift. The insights gained from this testing will, over time, allow us to improve instruction about this key component of evolution.

  6. Corporate Mentors and Undergraduate Students: A Qualitative Study of the Advancing Women in Construction Mentorship Program

    ERIC Educational Resources Information Center

    Eicher, Matthew

    2013-01-01

    In a conscious effort to combat the low enrollment of women in construction management, a program was created to retain women through a mentorship program--Advancing Women in Construction. A qualitative analysis, facilitated through a grounded theory approach, sought to understand if the program was indeed successful, and what value did the…

  7. Undergraduate Performance of Advanced Level and Associate Degree Students: A Comparative Analysis

    ERIC Educational Resources Information Center

    St. Rose, Kieran Winnifred

    2013-01-01

    In the English-speaking Caribbean, the Advanced level qualification is the traditional and preferred route to accessing an education at the University of the West Indies (UWI). However, applicants with nontraditional qualifications--such as the associate degree qualification, teacher certificate, diploma, and mature student status (meaning one who…

  8. Ring-Closing Metathesis: An Advanced Guided-Inquiry Experiment for the Organic Laboratory

    ERIC Educational Resources Information Center

    Schepmann, Hala G.; Mynderse, Michelle

    2010-01-01

    The design and implementation of an advanced guided-inquiry experiment for the organic laboratory is described. Grubbs's second-generation catalyst is used to effect the ring-closing metathesis of diethyl diallylmalonate. The reaction is carried out under an inert atmosphere at room temperature and monitored by argentic TLC. The crude reaction is…

  9. Understanding Fluorescence Measurements through a Guided-Inquiry and Discovery Experiment in Advanced Analytical Laboratory

    ERIC Educational Resources Information Center

    Wilczek-Vera, Grazyna; Salin, Eric Dunbar

    2011-01-01

    An experiment on fluorescence spectroscopy suitable for an advanced analytical laboratory is presented. Its conceptual development used a combination of the expository and discovery styles. The "learn-as-you-go" and direct "hands-on" methodology applied ensures an active role for a student in the process of visualization and discovery of concepts.…

  10. Adapting Advanced Inorganic Chemistry Lecture and Laboratory Instruction for a Legally Blind Student

    ERIC Educational Resources Information Center

    Miecznikowski, John R.; Guberman-Pfeffer, Matthew J.; Butrick, Elizabeth E.; Colangelo, Julie A.; Donaruma, Cristine E.

    2015-01-01

    In this article, the strategies and techniques used to successfully teach advanced inorganic chemistry, in the lecture and laboratory, to a legally blind student are described. At Fairfield University, these separate courses, which have a physical chemistry corequisite or a prerequisite, are taught for junior and senior chemistry and biochemistry…

  11. Modeling Stretching Modes of Common Organic Molecules with the Quantum Mechanical Harmonic Oscillator: An Undergraduate Vibrational Spectroscopy Laboratory Exercise

    ERIC Educational Resources Information Center

    Parnis, J. Mark; Thompson, Matthew G. K.

    2004-01-01

    An introductory undergraduate physical organic chemistry exercise that introduces the harmonic oscillator's use in vibrational spectroscopy is developed. The analysis and modeling exercise begins with the students calculating the stretching modes of common organic molecules with the help of the quantum mechanical harmonic oscillator (QMHO) model.

  12. Analysis of Bromination of Ethylbenzene Using a 45 MHz NMR Spectrometer: An Undergraduate Organic Chemistry Laboratory Experiment

    ERIC Educational Resources Information Center

    Isaac-Lam, Meden F.

    2014-01-01

    A 45 MHz benchtop NMR spectrometer is used to identify the structures and determine the amount of 1-bromoethylbenzene and 1,1-dibromoethylbenzene produced from free-radical bromination of ethylbenzene. The experiment is designed for nonchemistry majors, specifically B.S. Biology students, in a predominantly undergraduate institution with…

  13. The Genomics Education Partnership: Successful Integration of Research into Laboratory Classes at a Diverse Group of Undergraduate Institutions

    ERIC Educational Resources Information Center

    Shaffer, Christopher D.; Alvarez, Consuelo; Bailey, Cheryl; Barnard, Daron; Bhalla, Satish; Chandrasekaran, Chitra; Chandrasekaran, Vidya; Chung, Hui-Min; Dorer, Douglas R.; Du, Chunguang; Eckdahl, Todd T.; Poet, Jeff L.; Frohlich, Donald; Goodman, Anya L.; Gosser, Yuying; Hauser, Charles; Hoopes, Laura L. M.; Johnson, Diana; Jones, Christopher J.; Kaehler, Marian; Kokan, Nighat; Kopp, Olga R.; Kuleck, Gary A.; McNeil, Gerard; Moss, Robert; Myka, Jennifer L.; Nagengast, Alexis; Morris, Robert; Overvoorde, Paul J.; Shoop, Elizabeth; Parrish, Susan; Reed, Kelynne; Regisford, E. Gloria; Revie, Dennis; Rosenwald, Anne G.; Saville, Ken; Schroeder, Stephanie; Shaw, Mary; Skuse, Gary; Smith, Christopher; Smith, Mary; Spana, Eric P.; Spratt, Mary; Stamm, Joyce; Thompson, Jeff S.; Wawersik, Matthew; Wilson, Barbara A.; Youngblom, Jim; Leung, Wilson; Buhler, Jeremy; Mardis, Elaine R.; Lopatto, David; Elgin, Sarah C. R.

    2010-01-01

    Genomics is not only essential for students to understand biology but also provides unprecedented opportunities for undergraduate research. The goal of the Genomics Education Partnership (GEP), a collaboration between a growing number of colleges and universities around the country and the Department of Biology and Genome Center of Washington…

  14. An Undergraduate Laboratory Exercise to Study the Effect of Darkness on Plant Gene Expression Using DNA Microarray

    ERIC Educational Resources Information Center

    Chang, Ming-Mei; Briggs, George M.

    2007-01-01

    DNA microarrays are microscopic arrays on a solid surface, typically a glass slide, on which DNA oligonucleotides are deposited or synthesized in a high-density matrix with a predetermined spatial order. Several types of DNA microarrays have been developed and used for various biological studies. Here, we developed an undergraduate laboratory…

  15. Determination of Surface Tension of Surfactant Solutions through Capillary Rise Measurements: An Image-Processing Undergraduate Laboratory Experiment

    ERIC Educational Resources Information Center

    Huck-Iriart, Cristia´n; De-Candia, Ariel; Rodriguez, Javier; Rinaldi, Carlos

    2016-01-01

    In this work, we described an image processing procedure for the measurement of surface tension of the air-liquid interface using isothermal capillary action. The experiment, designed for an undergraduate course, is based on the analysis of a series of solutions with diverse surfactant concentrations at different ionic strengths. The objective of…

  16. Immersing Undergraduate Students in the Research Experience: A Practical Laboratory Module on Molecular Cloning of Microbial Genes

    ERIC Educational Resources Information Center

    Wang, Jack T. H.; Schembri, Mark A.; Ramakrishna, Mathitha; Sagulenko, Evgeny; Fuerst, John A.

    2012-01-01

    Molecular cloning skills are an essential component of biological research, yet students often do not receive this training during their undergraduate studies. This can be attributed to the complexities of the cloning process, which may require many weeks of progressive design and experimentation. To address this issue, we incorporated an…

  17. Azeotropic Preparation of a "C"-Phenyl "N"-Aryl Imine: An Introductory Undergraduate Organic Chemistry Laboratory Experiment

    ERIC Educational Resources Information Center

    Silverberg, Lee J.; Coyle, David J.; Cannon, Kevin C.; Mathers, Robert T.; Richards, Jeffrey A.; Tierney, John

    2016-01-01

    Imines are important in biological chemistry and as intermediates in organic synthesis. An experiment for introductory undergraduate organic chemistry is presented in which benzaldehyde was condensed with "p"-methoxyaniline in toluene to give 4-methoxy-"N"-(phenylmethylene)benzenamine. Water was removed by azeotropic…

  18. Undergraduate Professional Education in Chemistry: Guidelines and Evaluation Procedures.

    ERIC Educational Resources Information Center

    American Chemical Society, Washington, DC.

    Provided are guidelines for evaluating undergraduate professional education in chemistry. The guidelines summarize an approved program as including: 400 hours of classroom work; 500 hours of laboratory work; a core curriculum covering principles of analytical, inorganic, organic, and physical chemistry; 1 year of advanced work in chemistry or…

  19. Becoming a scientist: A qualitative study of the educational experience of undergraduates working in an American and a Brazilian research laboratory

    NASA Astrophysics Data System (ADS)

    Pascoa, Maria Beatriz Amorim

    Because the production of scientific and technological innovations has been at the center of debates for economic growth, scientists are recognized as important actors in the current global market. In this study, I will examine the undergraduate education of future scientists by focusing on students working in research projects of faculty members. This research activity has been promoted by American and Brazilian public agencies as an attempt to attract more college students to scientific careers as well as to improve their future performance in science. Evaluations of these programs have focused on important quantitative indicators focusing mainly on the amount of students that later choose to pursue scientific careers. However, these studies fail to address important educational aspects of undergraduates' experience. In this research, I explore the educational processes taking place as students are introduced to the making of science in order to understand how and what they are learning. Three bodies of literature illuminates the formulation and the analysis of the research questions: (1) theories of globalization situate the education of scientists within the dynamics of a broader social, economic, cultural, and historical framework; (2) the critical pedagogy of Paulo Freire is the basis for the understanding of the pedagogical processes shaping undergraduate students' experiences within the research site; (3) Critical and Cultural Studies of Science and Technology illuminate the analysis of the complex interactions and practices constructed within the laboratory. In order to understand the educational processes shaping the experiences of undergraduate students engaged in research activities, I conducted a qualitative investigation based on participant-observation and in-depth interviews in an American and a Brazilian laboratories. The two sites constituted insightful case studies that illuminated the understanding of inquires about the training of students in

  20. Undergraduate nursing students' experiences when examining nursing skills in clinical simulation laboratories with high-fidelity patient simulators: A phenomenological research study.

    PubMed

    Sundler, Annelie J; Pettersson, Annika; Berglund, Mia

    2015-12-01

    Simulation has become a widely used and established pedagogy for teaching clinical nursing skills. Nevertheless, the evidence in favour of this pedagogical approach is weak, and more knowledge is needed in support of its use. The aim of this study was (a) to explore the experiences of undergraduate nursing students when examining knowledge, skills and competences in clinical simulation laboratories with high-fidelity patient simulators and (b) to analyse these students' learning experiences during the examination. A phenomenological approach was used, and qualitative interviews were conducted among 23 second-year undergraduate nursing students-17 women and 6 men. The findings revealed that, irrespective of whether they passed or failed the examination, it was experienced as a valuable assessment of the students' knowledge and skills. Even if the students felt that the examination was challenging, they described it as a learning opportunity. In the examination, the students were able to integrate theory with practice, and earlier established knowledge was scrutinised when reflecting on the scenarios. The examination added aspects to the students' learning that prepared them for the real world of nursing in a safe environment without risking patient safety. The study findings suggest that examinations in clinical simulation laboratories can be a useful teaching strategy in nursing education. The use of high-fidelity patient simulators made the examination authentic. The reflections and feedback on the scenario were described as significant for the students' learning. Undergraduate nursing students can improve their knowledge, understanding, competence and skills when such examinations are performed in the manner used in this study.

  1. Environmental regulation of plant gene expression: an RT-qPCR laboratory project for an upper-level undergraduate biochemistry or molecular biology course.

    PubMed

    Eickelberg, Garrett J; Fisher, Alison J

    2013-01-01

    We present a novel laboratory project employing "real-time" RT-qPCR to measure the effect of environment on the expression of the FLOWERING LOCUS C gene, a key regulator of floral timing in Arabidopsis thaliana plants. The project requires four 3-hr laboratory sessions and is aimed at upper-level undergraduate students in biochemistry or molecular biology courses. The project provides students with hands-on experience with RT-qPCR, the current "gold standard" for gene expression analysis, including detailed data analysis using the common 2-ΔΔCT method. Moreover, it provides a convenient starting point for many inquiry-driven projects addressing diverse questions concerning ecological biochemistry, naturally occurring genetic variation, developmental biology, and the regulation of gene expression in nature.

  2. Reference site selection report for the advanced liquid metal reactor at the Idaho National Engineering Laboratory

    SciTech Connect

    Sivill, R.L.

    1990-03-01

    This Reference Site Selection Report was prepared by EG G, Idaho Inc., for General Electric (GE) to provide information for use by the Department of Energy (DOE) in selecting a Safety Test Site for an Advanced Liquid Metal Reactor. Similar Evaluation studies are planned to be conducted at other potential DOE sites. The Power Reactor Innovative Small Module (PRISM) Concept was developed for ALMR by GE. A ALMR Safety Test is planned to be performed on a DOE site to demonstrate features and meet Nuclear Regulatory Commission Requirements. This study considered possible locations at the Idaho National Engineering Laboratory that met the ALMR Prototype Site Selection Methodology and Criteria. Four sites were identified, after further evaluation one site was eliminated. Each of the remaining three sites satisfied the criteria and was graded. The results were relatively close. Thus concluding that the Idaho National Engineering Laboratory is a suitable location for an Advanced Liquid Metal Reactor Safety Test. 23 refs., 13 figs., 9 tabs.

  3. Jonathan F. Reichert and Barbara Wolff-Reichert Award for Excellence in Advanced Laboratory Instruction: Advanced Instructional Labs: Why Bother?

    NASA Astrophysics Data System (ADS)

    Bistrow, Van

    What aren't we teaching about physics in the traditional lecture course? Plenty! By offering the Advanced Laboratory Course, we hope to shed light on the following questions: How do we develop a systematic process of doing experiments? How do we record procedures and results? How should we interpret theoretical concepts in the real world? What experimental and computational techniques are available for producing and analyzing data? With what degree of confidence can we trust our measurements and interpretations? How well does a theory represent physical reality? How do we collaborate with experimental partners? How do we best communicate our findings to others?These questions are of fundamental importance to experimental physics, yet are not generally addressed by reading textbooks, attending lectures or doing homework problems. Thus, to provide a more complete understanding of physics, we offer laboratory exercises as a supplement to the other modes of learning. The speaker will describe some examples of experiments, and outline the history, structure and student impressions of the Advanced Lab course at the University of Chicago Department of Physics.

  4. Integrated safeguards testing laboratories in support of the advanced fuel cycle initiative

    SciTech Connect

    Santi, Peter A; Demuth, Scott F; Klasky, Kristen L; Lee, Haeok; Miller, Michael C; Sprinkle, James K; Tobin, Stephen J; Williams, Bradley

    2009-01-01

    A key enabler for advanced fuel cycle safeguards research and technology development for programs such as the Advanced Fuel Cycle Initiative (AFCI) is access to facilities and nuclear materials. This access is necessary in many cases in order to ensure that advanced safeguards techniques and technologies meet the measurement needs for which they were designed. One such crucial facility is a hot cell based laboratory which would allow developers from universities, national laboratories, and commercial companies to perform iterative research and development of advanced safeguards instrumentation under realistic operating conditions but not be subject to production schedule limitations. The need for such a facility arises from the requirement to accurately measure minor actinide and/or fission product bearing nuclear materials that cannot be adequately shielded in glove boxes. With the contraction of the DOE nuclear complex following the end of the cold war, many suitable facilities at DOE sites are increasingly costly to operate and are being evaluated for closure. A hot cell based laboratory that allowed developers to install and remove instrumentation from the hot cell would allow for both risk mitigation and performance optimization of the instrumentation prior to fielding equipment in facilities where maintenance and repair of the instrumentation is difficult or impossible. These benefits are accomplished by providing developers the opportunity to iterate between testing the performance of the instrumentation by measuring realistic types and amounts of nuclear material, and adjusting and refining the instrumentation based on the results of these measurements. In this paper, we review the requirements for such a facility using the Wing 9 hot cells in the Los Alamos National Laboratory's Chemistry and Metallurgy Research facility as a model for such a facility and describe recent use of these hot cells in support of AFCI.

  5. Precision laser range finder system design for Advanced Technology Laboratory applications

    NASA Technical Reports Server (NTRS)

    Golden, K. E.; Kohn, R. L.; Seib, D. H.

    1974-01-01

    Preliminary system design of a pulsed precision ruby laser rangefinder system is presented which has a potential range resolution of 0.4 cm when atmospheric effects are negligible. The system being proposed for flight testing on the advanced technology laboratory (ATL) consists of a modelocked ruby laser transmitter, course and vernier rangefinder receivers, optical beacon retroreflector tracking system, and a network of ATL tracking retroreflectors. Performance calculations indicate that spacecraft to ground ranging accuracies of 1 to 2 cm are possible.

  6. Investigations of Polymorphic Germylene Structures, Experimental Calculations of a New Boron-Sulfur Heterocycle and Assessment of a Safety Curriculum in an Undergraduate Laboratory

    NASA Astrophysics Data System (ADS)

    Rohr Daniel, Ahleah

    The dynamic interaction between chemistry and humankind is explored via investigations with benign substrates and the incorporation of proper laboratory technique instruction to a general audience. This intersection will be discussed in further detail in the introductory chapter of this thesis. The second chapter of this thesis describes the determination of two polymorphic structures from relatively non-toxic Cp*GeCl. The investigation of the polymorphic stability led to discovery of a solution equilibrium between monomeric and dimeric or higher oligomeric species. These experiments revealed the conversion of polymorphic structures in solid state and solution, allowing a thorough exploration of the thermodynamic and kinetic stability of each of the polymorphic structures. The third chapter of this dissertation describes computational analysis of the aromaticity of the recently prepared boron heterocycle, 2-diiosopropylamino-2 H-1,2-thiaborin. The importance and potential utility of aromatic boron-containing heterocycles in electronic devices and hydrogen storage is discussed. The theory behind computational chemistry and the analysis of the aromaticity, HOMO/LUMO, and nuclear magnetic resonance shifts of 2-diiosopropylamino-2 H-1,2-thiaborin are also reported. NICS (1) calculations determined that external pi-interactions of the external amino substituent greatly decrease the aromaticity of the parent ring. The fourth chapter describes the development and analysis of the effectiveness of a chemical hygiene-based laboratory curriculum incorporated in the University of Michigan undergraduate organic chemistry laboratory course, Chemistry 211. There is a great need to educate the general population of undergraduates enrolled in lower-division organic chemistry courses at the University of Michigan and in other universities in chemical hygiene. Previous laboratory curricula lacked in-depth discussions on proper laboratory practices. Through weekly reading assignments

  7. Synthesis and Small Molecule Exchange Studies of a Magnesium Bisformate Metal-Organic Framework: An Experiment in Host-Guest Chemistry for the Undergraduate Laboratory

    ERIC Educational Resources Information Center

    Rood, Jeffrey A.; Henderson, Kenneth W.

    2013-01-01

    concepts of host-guest chemistry and size exclusion in porous metal-organic frameworks (MOFs). The experiment has been successfully carried out in both introductory and advanced-level inorganic chemistry laboratories. Students synthesized the porous MOF, alpha-Mg[subscript…

  8. A One-Pot Self-Assembly Reaction to Prepare a Supramolecular Palladium(II) Cyclometalated Complex: An Undergraduate Organometallic Laboratory Experiment

    ERIC Educational Resources Information Center

    Fernandez, Alberto; Lopez-Torres, Margarita; Fernandez, Jesus J.; Vazquez-Garcia, Digna; Vila, Jose M.

    2012-01-01

    A laboratory experiment for students in advanced inorganic chemistry is described. Students prepare palladium(II) cyclometalated complexes. A terdentate [C,N,O] Schiff base ligand is doubly deprotonated upon reaction with palladium(II) acetate in a self-assembly process to give a palladacycle with a characteristic tetranuclear structure. This…

  9. The use of U.S. Geological Survey CD-ROM-based petroleum assessments in undergraduate geology laboratories

    USGS Publications Warehouse

    Eves, R.L.; Davis, L.E.; Dyman, T.S.; Takahashi, K.I.

    2002-01-01

    Domestic oil production is declining and United States reliance on imported oil is increasing. America will be faced with difficult decisions that address the strategic, economic, and political consequences of its energy resources shortage. The geologically literate under-graduate student needs to be aware of current and future United States energy issues. The U.S. Geological Survey periodically provides energy assessment data via digitally-formatted CD-ROM publications. These publications are free to the public, and are well suited for use in undergraduate geology curricula. The U.S. Geological Survey (USGS) 1995 National Assessment of United States Oil and Gas Resources (Digital Data Series or DDS-30) (Gautier and others, 1996) is an excellent resource for introducing students to the strategies of hydrocarbon exploration and for developing skills in problem-solving and evaluating real data. This paper introduces the reader to DDS-30, summarizes the essential terminology and methodology of hydrocarbon assessment, and offers examples of exercises or questions that might be used in the introductory classroom. The USGS contact point for obtaining DDS-30 and other digital assessment volumes is also provided. Completing the sample exercises in this report requires a copy of DDS-30.

  10. A Multistep Organocatalysis Experiment for the Undergraduate Organic Laboratory: An Enantioselective Aldol Reaction Catalyzed by Methyl Prolinamide

    ERIC Educational Resources Information Center

    Wade, Edmir O.; Walsh, Kenneth E.

    2011-01-01

    In recent years, there has been an explosion of research concerning the area of organocatalysis. A multistep capstone laboratory project that combines traditional reactions frequently found in organic laboratory curriculums with this new field of research is described. In this experiment, the students synthesize a prolinamide-based organocatalyst…

  11. Team-Based Learning, Faculty Research, and Grant Writing Bring Significant Learning Experiences to an Undergraduate Biochemistry Laboratory Course

    ERIC Educational Resources Information Center

    Evans, Hedeel Guy; Heyl, Deborah L.; Liggit, Peggy

    2016-01-01

    This biochemistry laboratory course was designed to provide significant learning experiences to expose students to different ways of succeeding as scientists in academia and foster development and improvement of their potential and competency as the next generation of investigators. To meet these goals, the laboratory course employs three…

  12. Reinforcing the Links between Teaching and Research: Evaluation of a Scheme to Employ Undergraduate Students as Laboratory Assistants

    ERIC Educational Resources Information Center

    Hughes, Monica; Brown, Kate; Calvert, Jane

    2008-01-01

    A scheme was introduced to offer opportunities to second-year bioscience students to undertake part-time paid work in research laboratories. The aim was to provide students with a greater appreciation of bioscience research, to reinforce their laboratory skills and to encourage them to consider a research-based career. Students worked for 8 hours…

  13. Prepare, Do, Review: A Model Used to Reduce the Negative Feelings towards Laboratory Classes in an Introductory Chemistry Undergraduate Unit

    ERIC Educational Resources Information Center

    Spagnoli, Dino; Wong, Lawrence; Maisey, Shannan; Clemons, Tristan D.

    2017-01-01

    Student feelings towards the laboratory component of an introductory chemistry unit were evaluated in an action research study, over a three-year period at the University of Western Australia. In 2013 we found that the percentage of students with negative feelings towards the laboratory increased over the duration of a semester. In 2014 we…

  14. In Vivo Time-Lapse Imaging in the Zebrafish Lateral Line: A Flexible, Open-Ended Research Project for an Undergraduate Neurobiology Laboratory Course

    PubMed Central

    Marra, Molly H.; Tobias, Zachary J.C.; Cohen, Hannah R.; Glover, Greta; Weissman, Tamily A.

    2015-01-01

    The lateral line sensory system in fish detects movements in the water and allows fish to respond to predators, prey, and other stimuli. As the lateral line forms in the first two days of zebrafish development, axons extend caudally along the lateral surface of the fish, eventually forming synapses with hair cells of neuromasts. Growing lateral line axons are located superficially under the skin and can be labeled in living zebrafish using fluorescent protein expression. This system provides a relatively straightforward approach for in vivo time-lapse imaging of neuronal development in an undergraduate setting. Here we describe an upper-level neurobiology laboratory module in which students investigate aspects of axonal development in the zebrafish lateral line system. Students learn to handle and image living fish, collect time-lapse videos of moving mitochondria, and quantitatively measure mitochondrial dynamics by generating and analyzing kymographs of their movements. Energy demands may differ between axons with extending growth cones versus axons that have already reached their targets and are forming synapses. Since relatively little is known about this process in developing lateral line axons, students generate and test their own hypotheses regarding how mitochondrial dynamics may differ at two different time points in axonal development. Students also learn to incorporate into their analysis a powerful yet accessible quantitative tool, the kymograph, which is used to graph movement over time. After students measure and quantify dynamics in living fish at 1 and 2 days post fertilization, this module extends into independent projects, in which students can expand their studies in a number of different, inquiry-driven directions. The project can also be pared down for courses that wish to focus solely on the quantitative analysis (without fish handling), or vice versa. This research module provides a useful approach for the design of open-ended laboratory

  15. Assessing student perspectives of the laboratory, self-efficacy in chemistry, and attitudes towards science in an undergraduate first-semester general chemistry laboratory

    NASA Astrophysics Data System (ADS)

    Olave, Marcella

    Research is lacking in the general chemistry laboratory that explores the concerted affective predictor variables of student perspectives of the laboratory, self-efficacy in chemistry, and student attitudes towards science. There is little research on the assessment of variables in the affective domain to determine student experiences in the chemistry laboratory. Student experiences in this study were assessed by determining congruence between student perspectives of their actual and preferred general chemistry laboratory environment using the SLEI, and student attitudes towards careers as a scientist using the SAI II. Correlations between scales from the SLEI, SAI II along with the CCSS that measures self-efficacy in college chemistry were identified. A sample of eighty college students enrolled in a first-semester general chemistry laboratory responded to the SLEI, SAI II, and CCSS. A t test indicated there were no significant differences with student cohesiveness, integration, material environment, and rule clarity between the actual and preferred SLEI signifying congruence. There were significant differences between students actual and preferred perception of open-endedness (t = -3.59, df = 28, p = 0.00). Student attitudes towards careers as a scientist could not be determined using pretests and posttests of the SAI II due to a ceiling effect. There were positive significant correlations found between the scales of material environment, integration from the SLEI and the scale of student attitudes towards careers as a scientist using the SAI II. There were also positive significant correlations between self-efficacy for everyday applications, and self-efficacy for cognitive skills from the CCSS with the scale of student attitudes towards careers as a scientist. This study is of significance since it is the first study exploring congruence between the actual and preferred student perspectives of the laboratory using the SLEI in a first semester general chemistry

  16. High Energy Laboratory Astrophysics Experiments using electron beam ion traps and advanced light sources

    NASA Astrophysics Data System (ADS)

    Brown, Gregory V.; Beiersdorfer, Peter; Bernitt, Sven; Eberle, Sita; Hell, Natalie; Kilbourne, Caroline; Kelley, Rich; Leutenegger, Maurice; Porter, F. Scott; Rudolph, Jan; Steinbrugge, Rene; Traebert, Elmar; Crespo-Lopez-Urritia, Jose R.

    2015-08-01

    We have used the Lawrence Livermore National Laboratory's EBIT-I electron beam ion trap coupled with a NASA/GSFC microcalorimeter spectrometer instrument to systematically address problems found in the analysis of high resolution X-ray spectra from celestial sources, and to benchmark atomic physics codes employed by high resolution spectral modeling packages. Our results include laboratory measurements of transition energies, absolute and relative electron impact excitation cross sections, charge exchange cross sections, and dielectronic recombination resonance strengths. More recently, we have coupled to the Max-Plank Institute for Nuclear Physics-Heidelberg's FLASH-EBIT electron beam ion trap to third and fourth generation advanced light sources to measure photoexcitation and photoionization cross sections, as well as, natural line widths of X-ray transitions in highly charged iron ions. Selected results will be presented.

  17. The impact of recent advances in laboratory astrophysics on our understanding of the cosmos.

    PubMed

    Savin, D W; Brickhouse, N S; Cowan, J J; Drake, R P; Federman, S R; Ferland, G J; Frank, A; Gudipati, M S; Haxton, W C; Herbst, E; Profumo, S; Salama, F; Ziurys, L M; Zweibel, E G

    2012-03-01

    An emerging theme in modern astrophysics is the connection between astronomical observations and the underlying physical phenomena that drive our cosmos. Both the mechanisms responsible for the observed astrophysical phenomena and the tools used to probe such phenomena-the radiation and particle spectra we observe-have their roots in atomic, molecular, condensed matter, plasma, nuclear and particle physics. Chemistry is implicitly included in both molecular and condensed matter physics. This connection is the theme of the present report, which provides a broad, though non-exhaustive, overview of progress in our understanding of the cosmos resulting from recent theoretical and experimental advances in what is commonly called laboratory astrophysics. This work, carried out by a diverse community of laboratory astrophysicists, is increasingly important as astrophysics transitions into an era of precise measurement and high fidelity modeling.

  18. Request for Information from entities interested in commercializing Laboratory-developed advanced in vitro assessment technology

    SciTech Connect

    Intrator, Miranda Huang

    2016-03-30

    Los Alamos National Security, LLC (LANS) is the manager and operator of Los Alamos National Laboratory (Los Alamos) for the U.S. Department of Energy National Nuclear Security Administration under contract DE-AC52- 06NA25396. Los Alamos is a mission-centric Federally Funded Research and Development Center focused on solving critical national security challenges through science and engineering for both government and private customers. LANS is opening this formal Request for Information (RFI) to gauge interest in engaging as an industry partner to LANS for collaboration in advancing the bio-assessment platform described below. Please see last section for details on submitting a Letter of Interest.

  19. A landmark recognition and tracking experiment for flight on the Shuttle/Advanced Technology Laboratory (ATL)

    NASA Technical Reports Server (NTRS)

    Welch, J. D.

    1975-01-01

    The preliminary design of an experiment for landmark recognition and tracking from the Shuttle/Advanced Technology Laboratory is described. It makes use of parallel coherent optical processing to perform correlation tests between landmarks observed passively with a telescope and previously made holographic matched filters. The experimental equipment including the optics, the low power laser, the random access file of matched filters and the electro-optical readout device are described. A real time optically excited liquid crystal device is recommended for performing the input non-coherent optical to coherent optical interface function. A development program leading to a flight experiment in 1981 is outlined.

  20. Synthesis and Characterization of Copper Complexes with a Tridentate Nitrogen-Donor Ligand: An Integrated Research Experiment for Undergraduate Students

    ERIC Educational Resources Information Center

    Bussey, Katherine A.; Cavalier, Annie R.; Connell, Jennifer R.; Mraz, Margaret E.; Holderread, Ashley S.; Oshin, Kayode D.; Pintauer, Tomislav

    2015-01-01

    An integrated laboratory experiment applying concepts and techniques developed in organic chemistry, inorganic chemistry, and instrumental analysis is presented for use by students interested in undergraduate research. The experiment incorporates some advanced laboratory practices such as multistep organic synthesis and purification, detailed…

  1. Gene Amplification by PCR and Subcloning into a GFP-Fusion Plasmid Expression Vector as a Molecular Biology Laboratory Course

    ERIC Educational Resources Information Center

    Bornhorst, Joshua A.; Deibel, Michael A.; Mulnix, Amy B.

    2004-01-01

    A novel experimental sequence for the advanced undergraduate laboratory course has been developed at Earlham College. Utilizing recent improvements in molecular techniques for a time-sensitive environment, undergraduates were able to create a chimera of a selected gene and green fluorescent protein (GFP) in a bacterial expression plasmid over the…

  2. Can the Tools of Activity Theory Help Us in Advancing Understanding and Organisational Change in Undergraduate Medical Education?

    ERIC Educational Resources Information Center

    Reid, Anne-Marie; Ledger, Alison; Kilminster, Sue; Fuller, Richard

    2015-01-01

    Continued changes to healthcare delivery in the UK, and an increasing focus on patient safety and quality improvement, require a radical rethink on how we enable graduates to begin work in challenging, complex environments. Professional regulatory bodies now require undergraduate medical schools to implement an "assistantship" period in…

  3. Teaching Thermodynamics and Kinetics to Advanced General Chemistry Students and to Upper-Level Undergraduate Students Using PV Diagrams

    ERIC Educational Resources Information Center

    Iyengar, Srinivasan S.; deSouza, Romualdo T.

    2014-01-01

    We describe how complex concepts in macroscopic chemistry, namely, thermodynamics and kinetics, can be taught at considerable depth both at the first-year undergraduate as well as upper levels. We begin with a careful treatment of PV diagrams, and by pictorially integrating the appropriate area in a PV diagram, we introduce work. This starting…

  4. A driver linac for the Advanced Exotic Beam Laboratory : physics design and beam dynamics simulations.

    SciTech Connect

    Ostroumov, P. N.; Mustapha, B.; Nolen, J.; Physics

    2007-01-01

    The Advanced Exotic Beam Laboratory (AEBL) being developed at ANL consists of an 833 MV heavy-ion driver linac capable of producing uranium ions up to 200 MeV/u and protons to 580 MeV with 400 kW beam power. We have designed all accelerator components including a two charge state LEBT, an RFQ, a MEBT, a superconducting linac, a stripper station and chicane. We present the results of an optimized linac design and end-to-end simulations including machine errors and detailed beam loss analysis. The Advanced Exotic Beam Laboratory (AEBL) has been proposed at ANL as a reduced scale of the original Rare Isotope Accelerator (RIA) project with about half the cost but the same beam power. AEBL will address 90% or more of RIA physics but with reduced multi-users capabilities. The focus of this paper is the physics design and beam dynamics simulations of the AEBL driver linac. The reported results are for a multiple charge state U{sup 238} beam.

  5. Using student-generated UV-induced Escherichia coli mutants in a directed inquiry undergraduate genetics laboratory.

    PubMed

    Healy, Frank G; Livingstone, Kevin D

    2010-09-01

    We report a thematic sequence of directed inquiry-based labs taking students from bacterial mutagenesis and phenotypic identification of their own self-created mutant, through identification of mutated genes by biochemical testing, to verification of mutant alleles by complementation, and finally to mutant allele characterization by DNA sequence analysis. The lab utilizes UV mutagenesis with wild-type Escherichia coli and a UV-sensitive isogenic derivative optimized for undergraduate use. The labs take advantage of the simplicity of E. coli in a realistic genetic investigation using safe UV irradiation methods for creation and characterization of novel mutants. Assessment data collected over three offerings of the course suggest that the labs, which combine original investigation in a scientifically realistic intellectual environment with learned techniques and concepts, were instrumental in improving students' learning in a number of areas. These include the development of critical thinking skills and understanding of concepts and methods. Student responses also suggest the labs were helpful in improving students' understanding of the scientific process as a rational series of experimental investigations and awareness of the interdisciplinary nature of scientific inquiry.

  6. A Western blot-based investigation of the yeast secretory pathway designed for an intermediate-level undergraduate cell biology laboratory.

    PubMed

    Hood-Degrenier, Jennifer K

    2008-01-01

    The movement of newly synthesized proteins through the endomembrane system of eukaryotic cells, often referred to generally as the secretory pathway, is a topic covered in most intermediate-level undergraduate cell biology courses. An article previously published in this journal described a laboratory exercise in which yeast mutants defective in two distinct steps of protein secretion were differentiated using a genetic reporter designed specifically to identify defects in the first step of the pathway, the insertion of proteins into the endoplasmic reticulum (Vallen, 2002). We have developed two versions of a Western blotting assay that serves as a second way of distinguishing the two secretory mutants, which we pair with the genetic assay in a 3-wk laboratory module. A quiz administered before and after students participated in the lab activities revealed significant postlab gains in their understanding of the secretory pathway and experimental techniques used to study it. A second survey administered at the end of the lab module assessed student perceptions of the efficacy of the lab activities; the results of this survey indicated that the experiments were successful in meeting a set of educational goals defined by the instructor.

  7. A Simple LIBS (Laser-Induced Breakdown Spectroscopy) Laboratory Experiment to Introduce Undergraduates to Calibration Functions and Atomic Spectroscopy

    ERIC Educational Resources Information Center

    Chinni, Rosemarie C.

    2012-01-01

    This laboratory experiment introduces students to a different type of atomic spectroscopy: laser-induced breakdown spectroscopy (LIBS). LIBS uses a laser-generated spark to excite the sample; once excited, the elemental emission is spectrally resolved and detected. The students use LIBS to analyze a series of standard synthetic silicate samples…

  8. Hands-On Experiences of Undergraduate Students in Automatics and Robotics Using a Virtual and Remote Laboratory

    ERIC Educational Resources Information Center

    Jara, Carlos A.; Candelas, Francisco A.; Puente, Santiago T.; Torres, Fernando

    2011-01-01

    Automatics and Robotics subjects are always greatly improved when classroom teaching is supported by adequate laboratory courses and experiments following the "learning by doing" paradigm, which provides students a deep understanding of theoretical lessons. However, expensive equipment and limited time prevent teachers having sufficient…

  9. Equilibrium Gel Filtration Chromatography for the Measurement of Protein-Ligand Binding in the Undergraduate Biochemistry Laboratory

    ERIC Educational Resources Information Center

    Craig, Douglas B.

    2005-01-01

    A laboratory exercise used in the senior biochemistry course at the University of Winnipeg for three years is discussed. It combines liquid chromatography and absorbance spectroscopy and also allows the students to produce a quantitative result within a single three-hour period.

  10. Cooperative and Active Learning in Undergraduate Biological Laboratories at FIU--Implications to TA Teaching and Training

    ERIC Educational Resources Information Center

    Penwell, Rebecca A.; Elsawa, Sherine F.; Pitzer, Thomas

    2004-01-01

    There were several changes in the laboratory teaching program in the Biological Sciences at Florida International University (FIU) between 1993-1994. The underlying goal was the improvement of the amount of material learned and retained by the student, but these changes showed little positive improvement. It was deemed necessary for FIU to…

  11. Drug Synthesis and Analysis on a Dime: A Capstone Medicinal Chemistry Experience for the Undergraduate Biochemistry Laboratory

    ERIC Educational Resources Information Center

    Streu, Craig N.; Reif, Randall D.; Neiles, Kelly Y.; Schech, Amanda J.; Mertz, Pamela S.

    2016-01-01

    Integrative, research-based experiences have shown tremendous potential as effective pedagogical approaches. Pharmaceutical development is an exciting field that draws heavily on organic chemistry and biochemistry techniques. A capstone drug synthesis/analysis laboratory is described where biochemistry students synthesize azo-stilbenoid compounds…

  12. Deaf, Hard-of-Hearing, and Hearing Signing Undergraduates' Attitudes toward Science in Inquiry-Based Biology Laboratory Classes.

    PubMed

    Gormally, Cara

    2017-01-01

    For science learning to be successful, students must develop attitudes toward support future engagement with challenging social issues related to science. This is especially important for increasing participation of students from underrepresented populations. This study investigated how participation in inquiry-based biology laboratory classes affected students' attitudes toward science, focusing on deaf, hard-of-hearing, and hearing signing students in bilingual learning environments (i.e., taught in American Sign Language and English). Analysis of reflection assignments and interviews revealed that the majority of students developed positive attitudes toward science and scientific attitudes after participating in inquiry-based biology laboratory classes. Attitudinal growth appears to be driven by student value of laboratory activities, repeated direct engagement with scientific inquiry, and peer collaboration. Students perceived that hands-on experimentation involving peer collaboration and a positive, welcoming learning environment were key features of inquiry-based laboratories, affording attitudinal growth. Students who did not perceive biology as useful for their majors, careers, or lives did not develop positive attitudes. Students highlighted the importance of the climate of the learning environment for encouraging student contribution and noted both the benefits and pitfalls of teamwork. Informed by students' characterizations of their learning experiences, recommendations are made for inquiry-based learning in college biology.

  13. Undergraduate Student Attitudes and Perceptions toward Low- and High-Level Inquiry Exercise Physiology Teaching Laboratory Experiences

    ERIC Educational Resources Information Center

    Henige, Kim

    2011-01-01

    The purpose of this investigation was to compare student attitudes toward two different science laboratory learning experiences, specifically, traditional, cookbook-style, low-inquiry level (LL) activities and a high-inquiry level (HL) investigative project. In addition, we sought to measure and compare students' science-related attitudes and…

  14. Combinatorial Solid-Phase Synthesis of Aromatic Oligoamides: A Research-Based Laboratory Module for Undergraduate Organic Chemistry

    ERIC Educational Resources Information Center

    Fuller, Amelia A.

    2016-01-01

    A five-week, research-based experiment suitable for second-semester introductory organic laboratory students is described. Each student designs, prepares, and analyzes a combinatorial array of six aromatic oligoamides. Molecules are prepared on solid phase via a six-step synthetic sequence, and purities and identities are determined by analysis of…

  15. Design and Laboratory Evaluation of Future Elongation and Diameter Measurements at the Advanced Test Reactor

    SciTech Connect

    K. L. Davis; D. L. Knudson; J. L. Rempe; J. C. Crepeau; S. Solstad

    2015-07-01

    New materials are being considered for fuel, cladding, and structures in next generation and existing nuclear reactors. Such materials can undergo significant dimensional and physical changes during high temperature irradiations. In order to accurately predict these changes, real-time data must be obtained under prototypic irradiation conditions for model development and validation. To provide such data, researchers at the Idaho National Laboratory (INL) High Temperature Test Laboratory (HTTL) are developing several instrumented test rigs to obtain data real-time from specimens irradiated in well-controlled pressurized water reactor (PWR) coolant conditions in the Advanced Test Reactor (ATR). This paper reports the status of INL efforts to develop and evaluate prototype test rigs that rely on Linear Variable Differential Transformers (LVDTs) in laboratory settings. Although similar LVDT-based test rigs have been deployed in lower flux Materials Testing Reactors (MTRs), this effort is unique because it relies on robust LVDTs that can withstand higher temperatures and higher fluxes than often found in other MTR irradiations. Specifically, the test rigs are designed for detecting changes in length and diameter of specimens irradiated in ATR PWR loops. Once implemented, these test rigs will provide ATR users with unique capabilities that are sorely needed to obtain measurements such as elongation caused by thermal expansion and/or creep loading and diameter changes associated with fuel and cladding swelling, pellet-clad interaction, and crud buildup.

  16. Cat dissection vs. sculpting human structures in clay: an analysis of two approaches to undergraduate human anatomy laboratory education.

    PubMed

    Waters, John R; Van Meter, Peggy; Perrotti, William; Drogo, Salvatore; Cyr, Richard J

    2005-03-01

    Many human anatomy courses are taught using cat dissection. Alternatives are available, but information regarding learning outcomes is incomplete. In 2003, approximately 120 undergraduates enrolled in a human anatomy course were assigned to one of two treatment groups. In the control group, students performed cat dissections (emphasizing isolation and identification) of the muscular, digestive, and cardiovascular systems. In the experimental treatment group, students built clay sculptures of each human body system. Student learning was evaluated by using both low- and high-difficulty questions. On pre- and postexperiment control exams, there were no significant differences in student performance. On exams after a cat dissection vs. a human-clay sculpting experience, the students in the human-clay sculpting treatment group scored significantly higher than their classmates in the cat dissection group on both the low- and high-difficulty questions. Student attitudes toward dissection and taking future human anatomy courses were also measured. There were no differences in student attitudes at the beginning of the experiment; afterward, students exposed to a cat dissection experience viewed dissection more favorably than students in the human-clay sculpting treatment group. There were no treatment effects on student willingness to take future human anatomy courses. The experimental design makes it difficult to conclude precisely why students assigned to the human-clay sculpting experience performed better on exams, but as each method was performed in this particular human anatomy course, our data indicate that human-clay sculpting may be a viable alternative to cat dissection in an anatomy course in which the students focus on human anatomy.

  17. Peer assessment in large undergraduate classes: an evaluation of a procedure for marking laboratory reports and a review of related practices.

    PubMed

    Harris, Judy R

    2011-06-01

    This study provides evidence that peer marking can be a reliable tool for assessing laboratory reports in large cohorts. It was conducted over a 4-yr period with first-year undergraduates (∼180 students/cohort) taking a mammalian physiology course, but the procedure adopted would be applicable to any other laboratory-based discipline. The process was found to be efficient in staff time, enabling a summative practical report to be marked in <1 h (<5% of the time that had previously been required for staff marking), facilitating rapid feedback to students on their performance. When samples of the peer-assessed reports were marked by a single member of staff, there was excellent correlation between peer and staff marks (r = 0.96-0.98), although peer-awarded marks exceeded staff marks by an average of 2.5-3.0%. The validity of peer marking was independent of both the sex of the marker and the staff score awarded to the marker for the same piece of work. Feedback from students was largely positive; they reported that the procedure adopted was effective in increasing their understanding of the underlying physiology and contributed to their understanding of best practice in presenting a laboratory report. Seventy percent of students agreed that it was acceptable for peer assessment to contribute a small (up to 5%) component of the overall mark for the course. The results are discussed in relation to other reports of peer marking, particularly when used to assess an academic product or process in a scientific discipline.

  18. Incorporating an ERP Project into Undergraduate Instruction

    PubMed Central

    Nyhus, Erika; Curtis, Nancy

    2016-01-01

    Electroencephalogram (EEG) is a relatively non-invasive, simple technique, and recent advances in open source analysis tools make it feasible to implement EEG as a component in undergraduate neuroscience curriculum. We have successfully led students to design novel experiments, record EEG data, and analyze event-related potentials (ERPs) during a one-semester laboratory course for undergraduates in cognitive neuroscience. First, students learned how to set up an EEG recording and completed an analysis tutorial. Students then learned how to set up a novel EEG experiment; briefly, they formed groups of four and designed an EEG experiment on a topic of their choice. Over the course of two weeks students collected behavioral and EEG data. Each group then analyzed their behavioral and ERP data and presented their results both as a presentation and as a final paper. Upon completion of the group project students reported a deeper understanding of cognitive neuroscience methods and a greater appreciation for the strengths and weaknesses of the EEG technique. Although recent advances in open source software made this project possible, it also required access to EEG recording equipment and proprietary software. Future efforts should be directed at making publicly available datasets to learn ERP analysis techniques and making publicly available EEG recording and analysis software to increase the accessibility of hands-on research experience in undergraduate cognitive neuroscience laboratory courses. PMID:27385925

  19. A Guided-Inquiry pH Laboratory Exercise for Introductory Biological Science Laboratories

    ERIC Educational Resources Information Center

    Snodgrass, Meagan A.; Lux, Nicholas; Metz, Anneke M.

    2011-01-01

    There is a continuing need for engaging inquiry-based laboratory experiences for advanced high school and undergraduate biology courses. The authors describe a guided-inquiry exercise investigating the pH-dependence of lactase enzyme that uses an inexpensive, wide-range buffering system, lactase dietary supplement, over-the-counter glucose test…

  20. Advances in Engine Test Capabilities at the NASA Glenn Research Center's Propulsion Systems Laboratory

    NASA Technical Reports Server (NTRS)

    Pachlhofer, Peter M.; Panek, Joseph W.; Dicki, Dennis J.; Piendl, Barry R.; Lizanich, Paul J.; Klann, Gary A.

    2006-01-01

    The Propulsion Systems Laboratory at the National Aeronautics and Space Administration (NASA) Glenn Research Center is one of the premier U.S. facilities for research on advanced aeropropulsion systems. The facility can simulate a wide range of altitude and Mach number conditions while supplying the aeropropulsion system with all the support services necessary to operate at those conditions. Test data are recorded on a combination of steady-state and highspeed data-acquisition systems. Recently a number of upgrades were made to the facility to meet demanding new requirements for the latest aeropropulsion concepts and to improve operational efficiency. Improvements were made to data-acquisition systems, facility and engine-control systems, test-condition simulation systems, video capture and display capabilities, and personnel training procedures. This paper discusses the facility s capabilities, recent upgrades, and planned future improvements.

  1. Temperature monitoring options available at the Idaho national laboratory advanced test reactor

    NASA Astrophysics Data System (ADS)

    Daw, J. E.; Rempe, J. L.; Knudson, D. L.; Unruh, T. C.; Chase, B. M.; Davis, K. L.; Palmer, A. J.

    2013-09-01

    As part of the Advanced Test Reactor National Scientific User Facility (ATR-NSUF) program, the Idaho National Laboratory (INL) has developed in-house capabilities to fabricate, test, and qualify new and enhanced temperature sensors for irradiation testing. Clearly, temperature sensor selection for irradiation tests will be determined based on the irradiation environment and budget. However, temperature sensors now offered by INL include a wide array of melt wires in small capsules, silicon carbide monitors, commercially available thermocouples, and specialized high temperature irradiation resistant thermocouples containing doped molybdenum and niobium alloy thermoelements. In addition, efforts have been initiated to develop and evaluate ultrasonic thermometers for irradiation testing. This array of temperature monitoring options now available to ATR and other Material and Test Reactor (MTR) users fulfills recent customer requests.

  2. Experiments in advanced control concepts for space robotics - An overview of the Stanford Aerospace Robotics Laboratory

    NASA Technical Reports Server (NTRS)

    Hollars, M. G.; Cannon, R. H., Jr.; Alexander, H. L.; Morse, D. F.

    1987-01-01

    The Stanford University Aerospace Robotics Laboratory is actively developing and experimentally testing advanced robot control strategies for space robotic applications. Early experiments focused on control of very lightweight one-link manipulators and other flexible structures. The results are being extended to position and force control of mini-manipulators attached to flexible manipulators and multilink manipulators with flexible drive trains. Experimental results show that end-point sensing and careful dynamic modeling or adaptive control are key to the success of these control strategies. Free-flying space robot simulators that operate on an air cushion table have been built to test control strategies in which the dynamics of the base of the robot and the payload are important.

  3. Hawaiian Electric Advanced Inverter Grid Support Function Laboratory Validation and Analysis

    SciTech Connect

    Nelson, Austin; Nagarajan, Adarsh; Prabakar, Kumar; Gevorgian, Vahan; Lundstrom, Blake; Nepal, Shaili; Hoke, Anderson; Asano, Marc; Ueda, Reid; Shindo, Jon; Kubojiri, Kandice; Ceria, Riley; Ifuku, Earle

    2016-12-01

    The objective for this test plan was to better understand how to utilize the performance capabilities of advanced inverter functions to allow the interconnection of distributed energy resource (DER) systems to support the new Customer Self-Supply, Customer Grid-Supply, and other future DER programs. The purpose of this project was: 1) to characterize how the tested grid supportive inverters performed the functions of interest, 2) to evaluate the grid supportive inverters in an environment that emulates the dynamics of O'ahu's electrical distribution system, and 3) to gain insight into the benefits of the grid support functions on selected O'ahu island distribution feeders. These goals were achieved through laboratory testing of photovoltaic inverters, including power hardware-in-the-loop testing.

  4. The Advanced Light Source at the Lawrence Berkeley Laboratory (ALS, LBL)

    SciTech Connect

    Jackson, A.

    1990-08-01

    The Advanced Light Source (ALS), a national facility currently under construction at the Lawrence Berkeley Laboratory (LBL), is a third-generation synchrotron light source designed to produce extremely bright beams of synchrotron radiation, in the energy range from a few eV to 10 keV. The design is based on a 1-1.9 GeV electron storage ring (optimized at 1.5 GeV), and utilizes special magnets, known as undulators and wigglers (collectively referred to as insertion devices), to generate the radiation. In this paper we describe the main accelerator components of the ALS, the variety of insertion devices, the radiation spectra expected from these devices, and the complement of experiments that have been approved for initial operation, starting in April 1993.

  5. Undergraduate student attitudes and perceptions toward low- and high-level inquiry exercise physiology teaching laboratory experiences.

    PubMed

    Henige, Kim

    2011-06-01

    The purpose of this investigation was to compare student attitudes toward two different science laboratory learning experiences, specifically, traditional, cookbook-style, low-inquiry level (LL) activities and a high-inquiry level (HL) investigative project. In addition, we sought to measure and compare students' science-related attitudes and attitudes toward science. Students participated in 5 wk of LL activities followed by a 5-wk HL project. An open-ended survey administered at the end of the semester and analyzed by a χ(2)-test revealed that 1) students enjoyed the HL project more than the LL activities, 2) high-level inquiry did not have a negative effect on student motivation in the laboratory, and 3) students perceived that they learned more about physiology principles with the LL activities. Most students liked the HL project, particularly the independence, responsibility, freedom, and personal relevance. Of the students who did not like the HL project, many reported being uncomfortable with the lack of structure and guidance. Many students gained a more positive and realistic view about scientific research, often reporting an increased respect for science. Likert scale surveys administered before and after each 5-wk period showed no significant changes in student attitudes to scientific inquiry, adoption of scientific attitudes, enjoyment of science lessons, or motivation toward science when the three time points were compared. The findings in this study have helped to provide suggestions for better implementation of HL projects in the future.

  6. Recent Advances in Laboratory Infrared Spectroscopy of Polycyclic Aromatic Hydrocarbons: PAHs in the Far Infrared

    NASA Technical Reports Server (NTRS)

    Mattioda, Andrew L.; Ricca, Alessandra; Tucker, Jonathan; Boersma, Christiaan; Bauschlicher, Charles, Jr.; Allamandola, Louis J.

    2010-01-01

    Over 25 years of observations and laboratory work have shown that the mid-IR spectra of a majority of astronomical sources are dominated by emission features near 3.3, 6.2, 7.7, and 11.2 microns, which originate in free polycyclic aromatic hydrocarbon (PAH) molecules. PAHs dominate the mid-IR emission from many galactic and extragalactic objects. As such, this material tracks a wide variety of astronomical processes, making this spectrum a powerful probe of the cosmos Apart from bands in the mid-IR, PAHs have bands spanning the Far-IR (FIR) and emission from these FIR features should be present in astronomical sources showing the Mid-IR PAH bands. However, with one exception, the FIR spectral characteristics are known only for a few neutral small PAHs trapped in salt pellets or oils at room temperature, data which is not relevant to astrophysics. Furthermore, since most emitting PAHs responsible for the mid-IR astronomical features are ionized, the absence of any experimental or theoretical PAH ion FIR spectra will make it impossible to correctly interpret the FIR data from these objects. In view of the upcoming Herschel space telescope mission and SOFIA's FIR airborne instrumentation, which will pioneer the FIR region, it is now urgent to obtain PAH FIR spectra. This talk will present an overview recent advances in the laboratory spectroscopy of PAHs, Highlighting the FIR spectroscopy along with some quantum calculations.

  7. RECENT ADVANCES IN HIGH TEMPERATURE ELECTROLYSIS AT IDAHO NATIONAL LABORATORY: STACK TESTS

    SciTech Connect

    X, Zhang; J. E. O'Brien; R. C. O'Brien; J. J. Hartvigsen; G. Tao; N. Petigny

    2012-07-01

    High temperature steam electrolysis is a promising technology for efficient sustainable large-scale hydrogen production. Solid oxide electrolysis cells (SOECs) are able to utilize high temperature heat and electric power from advanced high-temperature nuclear reactors or renewable sources to generate carbon-free hydrogen at large scale. However, long term durability of SOECs needs to be improved significantly before commercialization of this technology. A degradation rate of 1%/khr or lower is proposed as a threshold value for commercialization of this technology. Solid oxide electrolysis stack tests have been conducted at Idaho National Laboratory to demonstrate recent improvements in long-term durability of SOECs. Electrolytesupported and electrode-supported SOEC stacks were provided by Ceramatec Inc., Materials and Systems Research Inc. (MSRI), and Saint Gobain Advanced Materials (St. Gobain), respectively for these tests. Long-term durability tests were generally operated for a duration of 1000 hours or more. Stack tests based on technology developed at Ceramatec and MSRI have shown significant improvement in durability in the electrolysis mode. Long-term degradation rates of 3.2%/khr and 4.6%/khr were observed for MSRI and Ceramatec stacks, respectively. One recent Ceramatec stack even showed negative degradation (performance improvement) over 1900 hours of operation. A three-cell short stack provided by St. Gobain, however, showed rapid degradation in the electrolysis mode. Improvements on electrode materials, interconnect coatings, and electrolyteelectrode interface microstructures contribute to better durability of SOEC stacks.

  8. International Society for Advancement of Cytometry (ISAC) flow cytometry shared resource laboratory (SRL) best practices.

    PubMed

    Barsky, Lora W; Black, Michele; Cochran, Matthew; Daniel, Benjamin J; Davies, Derek; DeLay, Monica; Gardner, Rui; Gregory, Michael; Kunkel, Desiree; Lannigan, Joanne; Marvin, James; Salomon, Robert; Torres, Carina; Walker, Rachael

    2016-11-01

    The purpose of this document is to define minimal standards for a flow cytometry shared resource laboratory (SRL) and provide guidance for best practices in several important areas. This effort is driven by the desire of International Society for the Advancement of Cytometry (ISAC) members in SRLs to define and maintain standards of excellence in flow cytometry, and act as a repository for key elements of this information (e.g. example SOPs/training material, etc.). These best practices are not intended to define specifically how to implement these recommendations, but rather to establish minimal goals for an SRL to address in order to achieve excellence. It is hoped that once these best practices are established and implemented they will serve as a template from which similar practices can be defined for other types of SRLs. Identification of the need for best practices first occurred through discussions at the CYTO 2013 SRL Forum, with the most important areas for which best practices should be defined identified through several surveys and SRL track workshops as part of CYTO 2014. © 2016 International Society for Advancement of Cytometry.

  9. The effect of following learning style pathways on learning and satisfaction in online biology laboratories for non-science-major undergraduates

    NASA Astrophysics Data System (ADS)

    Ritschel-Trifilo, Patricia M.

    Learning is a biological process involving horizontal and vertical synapse formations in the brain resulting in established neuronal pathways. Each learner has a unique biological makeup resulting in individual approaches to acquire, understand, and perceive information, which constitutes their learning styles. Learners have a dominant and several subdominant learning styles they use to explore new material. This study investigates the effect of following learning style pathways on learning and satisfaction in an online biology laboratory for non-science-major undergraduates. Participants in the control group, without knowledge of learning styles, randomly chose from eight instructional strategies, to create a pathway to explore the subject of fermentation and enzymes. Each participant in the experimental group was tested to determine dominant and subdominant learning styles, and was then instructed to follow a specific pathway that conformed to his or her learning styles through the instructional materials to explore the topics. Results of the study show a statistically significant improvement in learning when instructional strategies are matched to dominant and subdominant learning styles compared to instructional strategies unmatched to learning styles. Learners following the learning style pathway exactly as suggested by Canfield Learning Styles Inventory, with the dominant instruction first, accomplished extremely significantly higher posttest scores over those who only partially followed the suggested learning path. Learners expressed a higher level of satisfaction with the instruction and greater ease of learning when the instructional strategies matched learning styles. Research results suggest that, if the instructional strategies incorporated into an online laboratory presenting unfamiliar material to learners do not match the learner's style, the learner is forced to use a brain pathway with little neuronal connectivity resulting in poor learning and

  10. Science of health care delivery as a first step to advance undergraduate medical education: A multi-institutional collaboration.

    PubMed

    Starr, Stephanie R; Reed, Darcy A; Essary, Alison; Hueston, William; Johnson, C Daniel; Landman, Natalie; Meurer, John; Miller, Bonnie; Ogrinc, Greg; Petty, Elizabeth M; Raymond, John; Riley, William; Gabriel, Sherine; Maurana, Cheryl

    2017-03-22

    Physicians must possess knowledge and skills to address the gaps facing the US health care system. Educators advocate for reform in undergraduate medical education (UME) to align competencies with the Triple Aim. In 2014, five medical schools and one state university began collaborating on these curricular gaps. The authors report a framework for the Science of Health Care Delivery (SHCD) using six domains and highlight curricular examples from each school. They describe three challenges and strategies for success in implementing SHCD curricula. This collaboration highlights the importance of multi-institutional partnerships to accelerate innovation and adaptation of curricula.

  11. Using Free Computational Resources to Illustrate the Drug Design Process in an Undergraduate Medicinal Chemistry Course

    ERIC Educational Resources Information Center

    Rodrigues, Ricardo P.; Andrade, Saulo F.; Mantoani, Susimaire P.; Eifler-Lima, Vera L.; Silva, Vinicius B.; Kawano, Daniel F.

    2015-01-01

    Advances in, and dissemination of, computer technologies in the field of drug research now enable the use of molecular modeling tools to teach important concepts of drug design to chemistry and pharmacy students. A series of computer laboratories is described to introduce undergraduate students to commonly adopted "in silico" drug design…

  12. Using Modern Solid-State Analytical Tools for Investigations of an Advanced Carbon Capture Material: Experiments for the Inorganic Chemistry Laboratory

    ERIC Educational Resources Information Center

    Wriedt, Mario; Sculley, Julian P.; Aulakh, Darpandeep; Zhou, Hong-Cai

    2016-01-01

    A simple and straightforward synthesis of an ultrastable porous metal-organic framework (MOF) based on copper(II) and a mixed N donor ligand system is described as a laboratory experiment for chemistry undergraduate students. These experiments and the resulting analysis are designed to teach students basic research tools and procedures while…

  13. The Marine Biological Laboratory (Woods Hole) and the scientific advancement of women in the early 20th century: the example of Mary Jane Hogue (1883-1962).

    PubMed

    Zottoli, Steven J; Seyfarth, Ernst-August

    2015-01-01

    The Marine Biological Laboratory (MBL) in Woods Hole, MA provided opportunities for women to conduct research in the late 19th and early 20th century at a time when many barriers existed to their pursuit of a scientific career. One woman who benefited from the welcoming environment at the MBL was Mary Jane Hogue. Her remarkable career as an experimental biologist spanned over 55 years. Hogue was born into a Quaker family in 1883 and received her undergraduate degree from Goucher College. She went to Germany to obtain an advanced degree, and her research at the University of Würzburg with Theodor Boveri resulted in her Ph.D. (1909). Although her research interests included experimental embryology, and the use of tissue culture to study a variety of cell types, she is considered foremost a protozoologist. Her extraordinary demonstration of chromidia (multiple fission) in the life history of a new species of Flabellula associated with diseased oyster beds is as important as it is ignored. We discuss Hogue's career path and her science to highlight the importance of an informal network of teachers, research advisors, and other women scientists at the MBL all of whom contributed to her success as a woman scientist.

  14. Evaluation of a novel method of chemical education: The Undergraduates Teaching Undergraduates program

    NASA Astrophysics Data System (ADS)

    McCreary, Christine Louise

    In 1995, the University of Pittsburgh was among a number of institutions in the country to join with the City College of the City University of New York in a novel research project, Workshop Chemistry, which fosters cooperative learning by utilizing advanced undergraduates to instruct and mentor other undergraduate students in both recitation and laboratory classes. That year, the Undergraduates Teaching Undergraduates (UTU) program was begun in the chemistry department at the University of Pittsburgh. In the UTU program, undergraduates who have completed an entry-level general chemistry course are trained as peer instructors, called UTUs, for that course. Both first and second term general chemistry classes at the University of Pittsburgh employ UTUs as well as traditional graduate teaching assistants (TAs) for both recitation and laboratory sections. This study investigated the effects of the UTU program in general chemistry laboratory classes by comparing the final exams of students in traditional TA-taught sections with exams of students taught by UTUs. The project was divided into two phases; the preparative measurement development phase in which the coding scheme and rubrics for analyzing the questions were developed and the evaluative learning outcome phase which assessed the students' achievement by examining their responses to three assessment questions. These questions dealt with student awareness of the structure of an experiment in terms of goals, procedures, conclusions and chemical concepts, logical thinking and verbal and written communication skills. The results of the analysis show that students in the UTU sections performed consistently better than students in TA sections, especially in areas that require critical thinking and understanding skills. In no cases examined were the learning outcomes negatively affected by UTU instruction.

  15. Recent advances in direct methanol fuel cells at Los Alamos National Laboratory

    NASA Astrophysics Data System (ADS)

    Ren, Xiaoming; Zelenay, Piotr; Thomas, Sharon; Davey, John; Gottesfeld, Shimshon

    This paper describes recent advances in the science and technology of direct methanol fuel cells (DMFCs) made at Los Alamos National Laboratory (LANL). The effort on DMFCs at LANL includes work devoted to portable power applications, funded by the Defense Advanced Research Project Agency (DARPA), and work devoted to potential transport applications, funded by the US DOE. We describe recent results with a new type of DMFC stack hardware that allows to lower the pitch per cell to 2 mm while allowing low air flow and air pressure drops. Such stack technology lends itself to both portable power and potential transport applications. Power densities of 300 W/l and 1 kW/l seem achievable under conditions applicable to portable power and transport applications, respectively. DMFC power system analysis based on the performance of this stack, under conditions applying to transport applications (joint effort with U.C. Davis), has shown that, in terms of overall system efficiency and system packaging requirements, a power source for a passenger vehicle based on a DMFC could compete favorably with a hydrogen-fueled fuel cell system, as well as with fuel cell systems based on fuel processing on board. As part of more fundamental studies performed, we describe optimization of anode catalyst layers in terms of PtRu catalyst nature, loading and catalyst layer composition and structure. We specifically show that, optimized content of recast ionic conductor added to the catalyst layer is a sensitive function of the nature of the catalyst. Other elements of membrane/electrode assembly (MEA) optimization efforts are also described, highlighting our ability to resolve, to a large degree, a well-documented problem of polymer electrolyte DMFCs, namely "methanol crossover". This was achieved by appropriate cell design, enabling fuel utilization as high as 90% in highly performing DMFCs.

  16. Completion summary for borehole USGS 136 near the Advanced Test Reactor Complex, Idaho National Laboratory, Idaho

    USGS Publications Warehouse

    Twining, Brian V.; Bartholomay, Roy C.; Hodges, Mary K.V.

    2012-01-01

    In 2011, the U.S. Geological Survey, in cooperation with the U.S. Department of Energy, cored and completed borehole USGS 136 for stratigraphic framework analyses and long-term groundwater monitoring of the eastern Snake River Plain aquifer at the Idaho National Laboratory. The borehole was initially cored to a depth of 1,048 feet (ft) below land surface (BLS) to collect core, open-borehole water samples, and geophysical data. After these data were collected, borehole USGS 136 was cemented and backfilled between 560 and 1,048 ft BLS. The final construction of borehole USGS 136 required that the borehole be reamed to allow for installation of 6-inch (in.) diameter carbon-steel casing and 5-in. diameter stainless-steel screen; the screened monitoring interval was completed between 500 and 551 ft BLS. A dedicated pump and water-level access line were placed to allow for aquifer testing, for collecting periodic water samples, and for measuring water levels. Geophysical and borehole video logs were collected after coring and after the completion of the monitor well. Geophysical logs were examined in conjunction with the borehole core to describe borehole lithology and to identify primary flow paths for groundwater, which occur in intervals of fractured and vesicular basalt. A single-well aquifer test was used to define hydraulic characteristics for borehole USGS 136 in the eastern Snake River Plain aquifer. Specific-capacity, transmissivity, and hydraulic conductivity from the aquifer test were at least 975 gallons per minute per foot, 1.4 × 105 feet squared per day (ft2/d), and 254 feet per day, respectively. The amount of measureable drawdown during the aquifer test was about 0.02 ft. The transmissivity for borehole USGS 136 was in the range of values determined from previous aquifer tests conducted in other wells near the Advanced Test Reactor Complex: 9.5 × 103 to 1.9 × 105 ft2/d. Water samples were analyzed for cations, anions, metals, nutrients, total organic

  17. Cold Crucible Induction Melter Testing at The Idaho National Laboratory for the Advanced Remediation Technologies Program

    SciTech Connect

    Jay Roach; Nick Soelberg; Mike Ancho; Eric Tchemitcheff; John Richardson

    2009-03-01

    AREVA Federal Services (AFS) is performing a multi-year, multi-phase Advanced Remediation Technologies (ART) project, sponsored by the U.S. Department of Energy (DOE), to evaluate the feasibility and benefits of replacing the existing joule-heated melter (JHM) used to treat high level waste (HLW) in the Defense Waste Processing Facility (DWPF) at the Savannah River Site with a cold crucible induction melter (CCIM). The AFS ART CCIM project includes several collaborators from AREVA subsidiaries, French companies, and DOE national laboratories. The Savannah River National Laboratory and the Commissariat a l’Energie Atomique (CEA) have performed laboratory-scale studies and testing to determine a suitable, high-waste-loading glass matrix. The Idaho National Laboratory (INL) and CEA are performing CCIM demonstrations at two different pilot scales to assess CCIM design and operation for treating SRS sludge wastes that are currently being treated in the DWPF. SGN is performing engineering studies to validate the feasibility of retrofitting CCIM technology into the DWPF Melter Cell. The long-term project plan includes more lab-testing, pilot- and large-scale demonstrations, and engineering activities to be performed during subsequent project phases. This paper provides preliminary results of tests using the engineering-scale CCIM test system located at the INL. The CCIM test system was operated continuously over a time period of about 58 hours. As the DWPF simulant feed was continuously fed to the melter, the glass level gradually increased until a portion of the molten glass was drained from the melter. The glass drain was operated semi-continuously because the glass drain rate was higher than the glass feedrate. A cold cap of unmelted feed was controlled by adjusting the feedrate and melter power levels to obtain the target molten glass temperatures with varying cold cap levels. Three test conditions were performed per the test plan, during which the melter was

  18. Microarrays for Undergraduate Classes

    ERIC Educational Resources Information Center

    Hancock, Dale; Nguyen, Lisa L.; Denyer, Gareth S.; Johnston, Jill M.

    2006-01-01

    A microarray experiment is presented that, in six laboratory sessions, takes undergraduate students from the tissue sample right through to data analysis. The model chosen, the murine erythroleukemia cell line, can be easily cultured in sufficient quantities for class use. Large changes in gene expression can be induced in these cells by…

  19. Advanced CNC and CAM Series. Educational Resources for the Machine Tool Industry. Course Syllabi, Instructor's Handbook [and] Student Laboratory Manual.

    ERIC Educational Resources Information Center

    Texas State Technical Coll. System, Waco.

    This package consists of course syllabi, an instructor's handbook, and student laboratory manual for a 1-year vocational training program to prepare students for entry-level positions as advanced computer numerical control (CNC) and computer-assisted manufacturing (CAM) technicians.. The program was developed through a modification of the DACUM…

  20. The Advanced Interdisciplinary Research Laboratory: A Student Team Approach to the Fourth-Year Research Thesis Project Experience

    ERIC Educational Resources Information Center

    Piunno, Paul A. E.; Boyd, Cleo; Barzda, Virginijus; Gradinaru, Claudiu C.; Krull, Ulrich J.; Stefanovic, Sasa; Stewart, Bryan

    2014-01-01

    The advanced interdisciplinary research laboratory (AIRLab) represents a novel, effective, and motivational course designed from the interdisciplinary research interests of chemistry, physics, biology, and education development faculty members as an alternative to the independent thesis project experience. Student teams are assembled to work…