Science.gov

Sample records for advancing regulatory science

  1. 76 FR 48169 - Advancing Regulatory Science for Highly Multiplexed Microbiology/Medical Countermeasure Devices...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-08

    ... Microbiology/ Medical Countermeasure Devices; Public Meeting AGENCY: Food and Drug Administration, HHS. ACTION... following public meeting: ``Advancing Regulatory Science for Highly Multiplexed Microbiology/Medical... multiplexed microbiology/medical countermeasure (MCM) devices, their clinical application and public...

  2. 76 FR 32364 - Collaboration in Regulatory Science and Capacity To Advance Global Access to Safe Vaccines and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-06

    ...The Food and Drug Administration (FDA) announces its intention to accept and consider a single source application for award of a cooperative agreement to the World Health Organization (WHO) in support of collaboration in regulatory science and capacity of National Regulatory Authorities (NRAs) to advance global access to safe and effective vaccines and other biologicals that meet international......

  3. 77 FR 21785 - Medical Countermeasures Initiative Regulatory Science Symposium

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    ... HUMAN SERVICES Food and Drug Administration Medical Countermeasures Initiative Regulatory Science... Administration (FDA) is announcing the following meeting: Medical Countermeasures Initiative Regulatory Science... development, highlight work on regulatory science as it applies to the development and advancement of...

  4. The Critical Path Institute's approach to precompetitive sharing and advancing regulatory science.

    PubMed

    Woosley, R L; Myers, R T; Goodsaid, F

    2010-05-01

    Many successful large industries, such as computer-chip manufacturers, the cable television industry, and high-definition television developers,(1) have established successful precompetitive collaborations focusing on standards, applied science, and technology that advance the field for all stakeholders and benefit the public.(2) The pharmaceutical industry, however, has a well-earned reputation for fierce competition and did not demonstrate willingness to share data or knowledge until the US Food and Drug Administration (FDA) launched the Critical Path Initiative in 2004 (ref. 3). PMID:20407457

  5. Advancing regulatory science to bring novel medical devices for use in emergency care to market: the role of the Food and Drug Administration.

    PubMed

    Scully, Christopher G; Forrest, Shawn; Galeotti, Loriano; Schwartz, Suzanne B; Strauss, David G

    2015-04-01

    The Food and Drug Administration (FDA) performs regulatory science to provide science-based medical product regulatory decisions. This article describes the types of scientific research the FDA's Center for Devices and Radiological Health performs and highlights specific projects related to medical devices for emergency medicine. In addition, this article discusses how results from regulatory science are used by the FDA to support the regulatory process as well as how the results are communicated to the public. Regulatory science supports the FDA's mission to assure safe, effective, and high-quality medical products are available to patients. PMID:25128009

  6. Regulatory physiology discipline science plan

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The focus of the Regulatory Physiology discipline of the Space Physiology and Countermeasures Program is twofold. First, to determine and study how microgravity and associated factors of space flight affect the regulatory mechanisms by which humans adapt and achieve homeostasis and thereby regulate their ability to respond to internal and external signals; and, second, to study selected physiological systems that have been demonstrated to be influenced by gravity. The Regulatory Physiology discipline, as defined here, is composed of seven subdisciplines: (1) Circadian Rhythms, (2) Endocrinology, (3) Fluid and Electrolyte Regulation, (4) Hematology, (5) Immunology, (6) Metabolism and Nutrition, and (7) Temperature Regulation. The purpose of this Discipline Science Plan is to provide a conceptual strategy for NASA's Life Sciences Division research and development activities in the area of regulatory physiology. It covers the research areas critical to NASA's programmatic requirements for the Extended-Duration Orbiter, Space Station Freedom, and exploration mission science activities. These science activities include ground-based and flight; basic, applied, and operational; and animal and human research and development. This document summarizes the current status of the program, outlines available knowledge, establishes goals and objectives, identifies science priorities, and defines critical questions in regulatory physiology. It contains a general plan that will be used by both NASA Headquarters Program Offices and the field centers to review and plan basic, applied, and operational intramural and extramural research and development activities in this area.

  7. Advances in attosecond science

    NASA Astrophysics Data System (ADS)

    Calegari, Francesca; Sansone, Giuseppe; Stagira, Salvatore; Vozzi, Caterina; Nisoli, Mauro

    2016-03-01

    Attosecond science offers formidable tools for the investigation of electronic processes at the heart of important physical processes in atomic, molecular and solid-state physics. In the last 15 years impressive advances have been obtained from both the experimental and theoretical points of view. Attosecond pulses, in the form of isolated pulses or of trains of pulses, are now routinely available in various laboratories. In this review recent advances in attosecond science are reported and important applications are discussed. After a brief presentation of various techniques that can be employed for the generation and diagnosis of sub-femtosecond pulses, various applications are reported in atomic, molecular and condensed-matter physics.

  8. Global Summit on Regulatory Science 2013.

    PubMed

    Howard, Paul C; Tong, Weida; Weichold, Frank; Healy, Marion; Slikker, William

    2014-12-01

    Regulatory science has been defined as the science that is used to develop regulatory decisions by government bodies. Regulatory science encompasses many scientific disciplines that oversee many studies producing a wide array of data. These may include fundamental research into the cellular interaction or response to a particular chemical or substance, hazard-assessment and dose-response studies in animal species, neurophysiological or neurobehavioral studies, best practices for the generation and analysis of genomics data, bioinformatics approaches, and mathematical modeling of risk. The Global Summit on Regulatory Science is an international conference with a mission to explore emerging and innovative technologies, and provide a platform to enhance translation of basic science into regulatory applications. The Third Global Summit on Regulatory Science which focused on nanotechnology is discussed. PMID:25128336

  9. Genomics in the land of regulatory science.

    PubMed

    Tong, Weida; Ostroff, Stephen; Blais, Burton; Silva, Primal; Dubuc, Martine; Healy, Marion; Slikker, William

    2015-06-01

    Genomics science has played a major role in the generation of new knowledge in the basic research arena, and currently question arises as to its potential to support regulatory processes. However, the integration of genomics in the regulatory decision-making process requires rigorous assessment and would benefit from consensus amongst international partners and research communities. To that end, the Global Coalition for Regulatory Science Research (GCRSR) hosted the fourth Global Summit on Regulatory Science (GSRS2014) to discuss the role of genomics in regulatory decision making, with a specific emphasis on applications in food safety and medical product development. Challenges and issues were discussed in the context of developing an international consensus for objective criteria in the analysis, interpretation and reporting of genomics data with an emphasis on transparency, traceability and "fitness for purpose" for the intended application. It was recognized that there is a need for a global path in the establishment of a regulatory bioinformatics framework for the development of transparent, reliable, reproducible and auditable processes in the management of food and medical product safety risks. It was also recognized that training is an important mechanism in achieving internationally consistent outcomes. GSRS2014 provided an effective venue for regulators andresearchers to meet, discuss common issues, and develop collaborations to address the challenges posed by the application of genomics to regulatory science, with the ultimate goal of wisely integrating novel technical innovations into regulatory decision-making. PMID:25796433

  10. Advances in Autophagy Regulatory Mechanisms

    PubMed Central

    Gallagher, Laura E.; Williamson, Leon E.; Chan, Edmond Y. W.

    2016-01-01

    Autophagy plays a critical role in cell metabolism by degrading and recycling internal components when challenged with limited nutrients. This fundamental and conserved mechanism is based on a membrane trafficking pathway in which nascent autophagosomes engulf cytoplasmic cargo to form vesicles that transport their content to the lysosome for degradation. Based on this simple scheme, autophagy modulates cellular metabolism and cytoplasmic quality control to influence an unexpectedly wide range of normal mammalian physiology and pathophysiology. In this review, we summarise recent advancements in three broad areas of autophagy regulation. We discuss current models on how autophagosomes are initiated from endogenous membranes. We detail how the uncoordinated 51-like kinase (ULK) complex becomes activated downstream of mechanistic target of rapamycin complex 1 (MTORC1). Finally, we summarise the upstream signalling mechanisms that can sense amino acid availability leading to activation of MTORC1. PMID:27187479

  11. Advances in Autophagy Regulatory Mechanisms.

    PubMed

    Gallagher, Laura E; Williamson, Leon E; Chan, Edmond Y W

    2016-01-01

    Autophagy plays a critical role in cell metabolism by degrading and recycling internal components when challenged with limited nutrients. This fundamental and conserved mechanism is based on a membrane trafficking pathway in which nascent autophagosomes engulf cytoplasmic cargo to form vesicles that transport their content to the lysosome for degradation. Based on this simple scheme, autophagy modulates cellular metabolism and cytoplasmic quality control to influence an unexpectedly wide range of normal mammalian physiology and pathophysiology. In this review, we summarise recent advancements in three broad areas of autophagy regulation. We discuss current models on how autophagosomes are initiated from endogenous membranes. We detail how the uncoordinated 51-like kinase (ULK) complex becomes activated downstream of mechanistic target of rapamycin complex 1 (MTORC1). Finally, we summarise the upstream signalling mechanisms that can sense amino acid availability leading to activation of MTORC1. PMID:27187479

  12. SCIENCE BRIEF: ADVANCED CONCEPTS

    EPA Science Inventory

    Research on advanced concepts will evaluate and demonstrate the application of innovative infrastructure designs, management procedures and operational approaches. Advanced concepts go beyond simple asset management. The infusion of these advanced concepts into established wastew...

  13. 78 FR 20664 - 2013 Medical Countermeasures Initiative Regulatory Science Symposium

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ... HUMAN SERVICES Food and Drug Administration 2013 Medical Countermeasures Initiative Regulatory Science...) Regulatory Science Symposium. The symposium is intended to provide a forum for the exchange of ideas for medical countermeasure development, highlight work on regulatory science as it applies to the...

  14. From molecule to market access: drug regulatory science as an upcoming discipline.

    PubMed

    Gispen-de Wied, Christine C; Leufkens, Hubertus G M

    2013-11-01

    Regulatory science as a discipline has evolved over the past years with the object to boost and promote scientific rationale behind benefit/risk and decision making by regulatory authorities. The European Medicines Agency, EMA, the Food and Drug Administration, FDA, and the Japanese Pharmaceutical and Medical Devices Agency, PMDA, highlighted in their distinct ways the importance of regulatory science as a basis of good quality assessment in their strategic plans. The Medicines Evaluation Board, MEB, states: 'regulatory science is the science of developing and validating new standards and tools to evaluate and assess the benefit/risk of medicinal products, facilitating sound and transparent regulatory decision making'. Through analysis of regulatory frameworks itself and their effectiveness, however, regulatory science can also advance knowledge of these systems in general. The comprehensive guidance that is issued to complete an application dossier for regulatory product approval has seldomly been scrutinized for its efficiency. Since it is the task of regulatory authorities to protect and promote public health, it is understood that they take a cautious approach in regulating drugs prior to market access. In general, the authorities are among the first to be blamed if dangerous or useless drugs were allowed to the market. Yet, building a regulatory framework that is not challenged continuously in terms of deliverables for public health and cost-effectiveness, might be counterproductive in the end. Regulatory science and research can help understand how and why regulatory decisions are made, and where renewed discussions may be warranted. The MEB supports regulatory science as an R&D activity to fuel primary regulatory processes on product evaluation and vigilance, but also invests in a 'looking into the mirror' approach. Along the line of the drug life-cycle, publicly available data are reviewed and their regulatory impact highlighted. If made explicit

  15. Flipped Classrooms for Advanced Science Courses

    ERIC Educational Resources Information Center

    Tomory, Annette; Watson, Sunnie Lee

    2015-01-01

    This article explains how issues regarding dual credit and Advanced Placement high school science courses could be mitigated via a flipped classroom instructional model. The need for advanced high school courses will be examined initially, followed by an analysis of advanced science courses and the reform they are experiencing. Finally, it will…

  16. Regulatory science based approach in development of novel medical devices.

    PubMed

    Sakuma, Ichiro

    2015-08-01

    For development rational evaluation method for medical devices' safety and efficacy, regulatory science studies are important. Studies on regulatory affairs related to a medical device under development should be conducted as well as its technological development. Clinical performance of a medical device is influenced by performance of the device, medical doctors' skill, pathological condition of a patient, and so on. Thus it is sometimes difficult to demonstrate superiority of the device in terms of clinical outcome although its efficacy as a medical device is accepted. Setting of appropriate end points is required to evaluate a medical device appropriately. Risk assessment and risk management are the basis of medical device safety assurance. In case of medical device software, there are difficulties in identifying the risk due to its complexity of user environment and different design and manufacturing procedure compared with conventional hardware based medical devices. Recent technological advancement such as information and communication technologies (ICT) for medical devices and wireless network has raised new issue on risk management: cybersecurity. We have to watch closely the progress of safety standard development. PMID:26736611

  17. Advances in ambulatory monitoring: regulatory considerations.

    PubMed

    Buckles, David; Aguel, Felipe; Brockman, Randall; Cheng, James; Demian, Cindy; Ho, Charles; Jensen, Donald; Mallis, Elias

    2004-01-01

    Conventional ambulatory electrocardiogram (ECG) (Holter) monitoring involves 2 or 3 surface leads recorded with electrode positions and signal characteristics that are different from diagnostic quality 12-lead ECGs due to the limitations imposed by technology on the ambulatory recorders. The rapid pace of technological development for medical devices, particularly electrocardiography, has now enabled the recording of diagnostic quality 12-lead ECG waveforms for extended time periods. This capability allows Holter recording to become another source for diagnostic 12-lead ECG records on a par with other modalities such as resting ECG and exercise stress testing. Additionally, other diagnostic techniques such as S-T segment analysis and Q-T interval analysis that rely on diagnostic quality waveforms can now be applied. All of these enhancements to the traditional Holter modality have altered the regulatory perspective of these devices, since the enhancements may represent a new intended use for the device. PMID:15534803

  18. Advances in engineering science, volume 1

    NASA Technical Reports Server (NTRS)

    1976-01-01

    Proceedings from a conference on engineering advances are presented, including materials science, fracture mechanics, and impact and vibration testing. The tensile strength and moisture transport of laminates are also discussed.

  19. Physics in Advanced GNVQ Science.

    ERIC Educational Resources Information Center

    Sang, David

    1995-01-01

    Explores the approach adopted by General National Vocational Qualification (GNVQ) Science in Great Britain. The GNVQ is a vocational qualification for students and is part of a program to upgrade vocational education and training. Discusses the way in which appropriate teaching resources have been developed by the Nuffield Science in Practice…

  20. Advanced Reactor Technology -- Regulatory Technology Development Plan (RTDP)

    SciTech Connect

    Moe, Wayne Leland

    2015-05-01

    This DOE-NE Advanced Small Modular Reactor (AdvSMR) regulatory technology development plan (RTDP) will link critical DOE nuclear reactor technology development programs to important regulatory and policy-related issues likely to impact a “critical path” for establishing a viable commercial AdvSMR presence in the domestic energy market. Accordingly, the regulatory considerations that are set forth in the AdvSMR RTDP will not be limited to any one particular type or subset of advanced reactor technology(s) but rather broadly consider potential regulatory approaches and the licensing implications that accompany all DOE-sponsored research and technology development activity that deal with commercial non-light water reactors. However, it is also important to remember that certain “minimum” levels of design and safety approach knowledge concerning these technology(s) must be defined and available to an extent that supports appropriate pre-licensing regulatory analysis within the RTDP. Final resolution to advanced reactor licensing issues is most often predicated on the detailed design information and specific safety approach as documented in a facility license application and submitted for licensing review. Because the AdvSMR RTDP is focused on identifying and assessing the potential regulatory implications of DOE-sponsored reactor technology research very early in the pre-license application development phase, the information necessary to support a comprehensive regulatory analysis of a new reactor technology, and the resolution of resulting issues, will generally not be available. As such, the regulatory considerations documented in the RTDP should be considered an initial “first step” in the licensing process which will continue until a license is issued to build and operate the said nuclear facility. Because a facility license application relies heavily on the data and information generated by technology development studies, the anticipated regulatory

  1. Advancing Research on Undergraduate Science Learning

    ERIC Educational Resources Information Center

    Singer, Susan Rundell

    2013-01-01

    This special issue of "Journal of Research in Science Teaching" reflects conclusions and recommendations in the "Discipline-Based Education Research" (DBER) report and makes a substantial contribution to advancing the field. Research on undergraduate science learning is currently a loose affiliation of related fields. The…

  2. Lincoln Advanced Science & Engineering Reinforcement (LASER) Program.

    ERIC Educational Resources Information Center

    Williams, Willie

    The Lincoln Advanced Science and Engineering Reinforcement (LASER) Program at Lincoln University, which has recruited over 100 students for majors in technical fields, is described in this report. To date, over 70% have completed or will complete technical degrees in engineering, physics, chemistry, and computer science. Of those completing the…

  3. Flipped Classrooms for Advanced Science Courses

    NASA Astrophysics Data System (ADS)

    Tomory, Annette; Watson, Sunnie Lee

    2015-12-01

    This article explains how issues regarding dual credit and Advanced Placement high school science courses could be mitigated via a flipped classroom instructional model. The need for advanced high school courses will be examined initially, followed by an analysis of advanced science courses and the reform they are experiencing. Finally, it will conclude with an explanation of flipped classes as well as how they may be a solution to the reform challenges teachers are experiencing as they seek to incorporate more inquiry-based activities.

  4. 77 FR 46444 - Gastroenterology Regulatory Endpoints and the Advancement of Therapeutics (GREAT); Public Workshop

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-03

    ... HUMAN SERVICES Food and Drug Administration Gastroenterology Regulatory Endpoints and the Advancement of... announcing a 4-day public workshop entitled ``Gastroenterology Regulatory Endpoints and the Advancement of... endpoints that can support drug development in the following disease areas: Eosinophilic...

  5. Advances in welding science - a perspective

    SciTech Connect

    David, S.A.; Vitek, J.M.; Babu, S.S.; DebRoy, T.

    1995-02-01

    The ultimate goal of welding technology is to improve the joint integrity and increase productivity. Over the years, welding has been more of an art than a science, but in the last few decades major advances have taken place in welding science and technology. With the development of new methodologies at the crossroads of basic and applied sciences, enormous opportunities and potential exist to develop a science-based tailoring of composition, structure, and properties of welds with intelligent control and automation of the welding processes.

  6. The regulatory sciences for stem cell-based medicinal products.

    PubMed

    Yuan, Bao-Zhu; Wang, Junzhi

    2014-06-01

    Over the past few years, several new achievements have been made from stem cell studies, many of which have moved up from preclinical stages to early, or from early to middle or late, stages thanks to relatively safe profile and preliminary evidence of effectiveness. Moreover, some stem cell-based products have been approved for marketing by different national regulatory authorities. However, many critical issues associated mainly with incomplete understanding of stem cell biology and the relevant risk factors, and lack of effective regulations still exist and need to be urgently addressed, especially in countries where establishment of appropriate regulatory system just commenced. More relevantly, the stem cell regulatory sciences need to be established or improved to more effectively evaluate quality, safety and efficacy of stem cell products, and for building up the appropriate regulatory framework. In this review, we summarize some new achievements in stem cell studies, especially the preclinical and clinical studies, the existing regulations, and the associated challenges, and we then propose some considerations for improving stem cell regulatory sciences with a goal of promoting the steadfast growth of the well-regulated stem cell therapies abreast of evolvement of stem cell sciences and technologies. PMID:24733351

  7. Perspectives on an alternative career path in regulatory science.

    PubMed

    Fields, F Owen

    2013-07-01

    Perspectives are provided on an alternative career path in regulatory science for those currently involved in basic biology research. This path is compared and contrasted with basic research, and factors to be examined if one is considering such a path are discussed. PMID:23846346

  8. Perspectives on an alternative career path in regulatory science

    PubMed Central

    Fields, F. Owen

    2013-01-01

    Perspectives are provided on an alternative career path in regulatory science for those currently involved in basic biology research. This path is compared and contrasted with basic research, and factors to be examined if one is considering such a path are discussed. PMID:23846346

  9. The Advancement of Science - Science without Legend, Objectivity without Illusions

    NASA Astrophysics Data System (ADS)

    Kitcher, Philip

    1995-04-01

    During the last three decades, reflections on the growth of scientific knowledge have inspired historians, sociologists, and some philosophers to contend that scientific objectivity is a myth. In this book, Kitcher attempts to resurrect the notions of objectivity and progress in science by identifying both the limitations of idealized treatments of growth of knowledge and the overreactions to philosophical idealizations. Recognizing that science is done not by logically omniscient subjects working in isolation, but by people with a variety of personal and social interests, who cooperate and compete with one another, he argues that, nonetheless, we may conceive the growth of science as a process in which both our vision of nature and our ways of learning more about nature improve. Offering a detailed picture of the advancement of science, he sets a new agenda for the philosophy of science and for other "science studies" disciplines.

  10. Advancing Careers in Information Science and Technology

    ERIC Educational Resources Information Center

    Stanton, Wilbur W.; Templeton, Dennie E.; Chase, Joe D.; Rose, Melinda; Eaton, Carlotta

    2005-01-01

    The authors discuss the joining of 12 Virginia community colleges from the Appalachian region of southwestern Virginia with Radford University to form the Regional Technology Education Consortium (RTEC), a three-year project funded by the National Science Foundation Advanced Technological Education program and designed to develop articulation…

  11. Advances in the Science of Assessment

    ERIC Educational Resources Information Center

    Shute, Valerie J.; Leighton, Jacqueline P.; Jang, Eunice E.; Chu, Man-Wai

    2016-01-01

    Designing, developing, and administering assessments has remained fairly unchanged across the past century. However, recent developments in instructional technology, learning science theory, and advances in the design of assessments necessitate a newfound perspective on assessment. The objective of the present article is to review the topic of…

  12. Advanced Cyberinfrastructure Investments Addressing Earth Science Challenges

    NASA Astrophysics Data System (ADS)

    Walton, A. L.; Spengler, S. J.; Zanzerkia, E. E.

    2014-12-01

    The National Science Foundation supports infrastructure development and research into Big Data challenges as part of its long-term cyberinfrastructure strategy. This strategy highlights the critical need to leverage and partner with other agencies, resources and service providers to the U.S. research community. The current cyberinfrastructure and research activities within NSF support advanced technology development, pilot demonstrations of new capabilities for the scientific community in general, and integration and interoperability of data resources across the Geoscience community. These activities include the Data Infrastructure Building Blocks, Big Data and EarthCube programs, among others. Investments are competitively solicited; the resulting portfolio of high performance computing, advanced information systems, new software capabilities, analytics and modeling supports a range of science disciplines. This presentation provides an overview of these research programs, highlighting some of the key investments in advanced analytics, coupled modeling, and seamless collaboration. Examples related to the geosciences, computer-aided discovery and hypothesis generation are highlighted.

  13. 78 FR 27113 - Generic Drug User Fee Amendments of 2012; Regulatory Science Initiatives Public Hearing; Request...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-09

    ... drug research, with a focus on the following: 1. Identification of current regulatory science...; Regulatory Science Initiatives Public Hearing; Request for Comments AGENCY: Food and Drug Administration, HHS... of the regulatory science initiatives for generic drugs and an opportunity for public input...

  14. [Role of Academia in Regulatory Science for Global Drug Development].

    PubMed

    Tsukamoto, Katsura; Takenaka, Toichi

    2016-01-01

    As diseases know no national boundaries, drug development must be designed at a global level. Drugs are highly regulated to maximize the benefits to public health, which is assessed on a regional basis. The complexity and diversity of stakeholders increase dramatically once multiple international regions are involved. Each stakeholder in drug development depends on customized criteria to make decisions for its own benefit. Thus, a huge gap exists among drug discovery researchers, developers, clinicians, patients, and regulatory bodies. With reasonable scientific evidence gathered and analyzed, mutual agreement can be reached. We believe that this important role of regulatory science and academic involvement will create harmony. By practicing diverse, innovative regulatory scientific research, academia has the potential to become the core of communication among various stakeholder groups. Furthermore, another important responsibility of academia, i.e., knowledge, provides additional aspects to the field of drug development. Those who understand regulatory science can contribute to the efficient achievement of innovative, effective, safe drugs. Thus, research and education are essential roles of academia to allow a better understanding of the balance between benefits and risks. Communication and knowledge will promote the prompt delivery of better medical products to patients in need. PMID:27040336

  15. Recent advances in vacuum sciences and applications

    NASA Astrophysics Data System (ADS)

    Mozetič, M.; Ostrikov, K.; Ruzic, D. N.; Curreli, D.; Cvelbar, U.; Vesel, A.; Primc, G.; Leisch, M.; Jousten, K.; Malyshev, O. B.; Hendricks, J. H.; Kövér, L.; Tagliaferro, A.; Conde, O.; Silvestre, A. J.; Giapintzakis, J.; Buljan, M.; Radić, N.; Dražić, G.; Bernstorff, S.; Biederman, H.; Kylián, O.; Hanuš, J.; Miloševič, S.; Galtayries, A.; Dietrich, P.; Unger, W.; Lehocky, M.; Sedlarik, V.; Stana-Kleinschek, K.; Drmota-Petrič, A.; Pireaux, J. J.; Rogers, J. W.; Anderle, M.

    2014-04-01

    Recent advances in vacuum sciences and applications are reviewed. Novel optical interferometer cavity devices enable pressure measurements with ppm accuracy. The innovative dynamic vacuum standard allows for pressure measurements with temporal resolution of 2 ms. Vacuum issues in the construction of huge ultra-high vacuum devices worldwide are reviewed. Recent advances in surface science and thin films include new phenomena observed in electron transport near solid surfaces as well as novel results on the properties of carbon nanomaterials. Precise techniques for surface and thin-film characterization have been applied in the conservation technology of cultural heritage objects and recent advances in the characterization of biointerfaces are presented. The combination of various vacuum and atmospheric-pressure techniques enables an insight into the complex phenomena of protein and other biomolecule conformations on solid surfaces. Studying these phenomena at solid-liquid interfaces is regarded as the main issue in the development of alternative techniques for drug delivery, tissue engineering and thus the development of innovative techniques for curing cancer and cardiovascular diseases. A review on recent advances in plasma medicine is presented as well as novel hypotheses on cell apoptosis upon treatment with gaseous plasma. Finally, recent advances in plasma nanoscience are illustrated with several examples and a roadmap for future activities is presented.

  16. Advanced Sciences and Technology Research for Astrodynamics

    NASA Astrophysics Data System (ADS)

    Jah, M.

    The Advanced Sciences and Technology Research Institute for Astrodynamics (ASTRIA) has been created as a research endeavor that focuses all astrodynamics R&D within the Air Force Research Laboratory (AFRL). ASTRIA is mainly a consortium of academic partners brought together to bear on the nation's challenges as related to astrodynamics sciences and technologies. An overview of ASTRIA is presented as well as examples of several research efforts that are relevant to data/track association, UCT/cross-tagging mitigation, and attitude recovery from light curve data.

  17. Advancing Water Science through Improved Cyberinfrastructure

    NASA Astrophysics Data System (ADS)

    Koch, B. J.; Miles, B.; Rai, A.; Ahalt, S.; Band, L. E.; Minsker, B.; Palmer, M.; Williams, M. R.; Idaszak, R.; Whitton, M. C.

    2012-12-01

    Major scientific advances are needed to help address impacts of climate change and increasing human-mediated environmental modification on the water cycle at global and local scales. However, such advances within the water sciences are limited in part by inadequate information infrastructures. For example, cyberinfrastructure (CI) includes the integrated computer hardware, software, networks, sensors, data, and human capital that enable scientific workflows to be carried out within and among individual research efforts and across varied disciplines. A coordinated transformation of existing CI and development of new CI could accelerate the productivity of water science by enabling greater discovery, access, and interoperability of data and models, and by freeing scientists to do science rather than create and manage technological tools. To elucidate specific ways in which improved CI could advance water science, three challenges confronting the water science community were evaluated: 1) How does ecohydrologic patch structure affect nitrogen transport and fate in watersheds?, 2) How can human-modified environments emulate natural water and nutrient cycling to enhance both human and ecosystem well-being?, 3) How do changes in climate affect water availability to support biodiversity and human needs? We assessed the approaches used by researchers to address components of these challenges, identified barriers imposed by limitations of current CI, and interviewed leaders in various water science subdisciplines to determine the most recent CI tools employed. Our preliminary findings revealed four areas where CI improvements are likely to stimulate scientific advances: 1) sensor networks, 2) data quality assurance/quality control, 3) data and modeling standards, 4) high performance computing. In addition, the full potential of a re-envisioned water science CI cannot be realized without a substantial training component. In light of these findings, we suggest that CI

  18. Scientific and Legal Perspectives on Science Generated for Regulatory Activities

    PubMed Central

    Henry, Carol J.; Conrad, James W.

    2008-01-01

    This article originated from a conference that asked “Should scientific work conducted for purposes of advocacy before regulatory agencies or courts be judged by the same standards as science conducted for other purposes?” In the article, which focuses on the regulatory advocacy context, we argue that it can be and should be. First, we describe a set of standards and practices currently being used to judge the quality of scientific research and testing and explain how these standards and practices assist in judging the quality of research and testing regardless of why the work was conducted. These standards and practices include the federal Information Quality Act, federal Good Laboratory Practice standards, peer review, disclosure of funding sources, and transparency in research policies. The more that scientific information meets these standards and practices, the more likely it is to be of high quality, reliable, reproducible, and credible. We then explore legal issues that may be implicated in any effort to create special rules for science conducted specifically for a regulatory proceeding. Federal administrative law does not provide a basis for treating information in a given proceeding differently depending on its source or the reason for which it was generated. To the contrary, this law positively assures that interested persons have the right to offer their technical expertise toward the solution of regulatory problems. Any proposal to subject scientific information generated for the purpose of a regulatory proceeding to more demanding standards than other scientific information considered in that proceeding would clash with this law and would face significant administrative complexities. In a closely related example, the U.S. Environmental Protection Agency considered but abandoned a program to implement standards aimed at “external” information. PMID:18197313

  19. Advancing Water Science through Data Visualization

    NASA Astrophysics Data System (ADS)

    Li, X.; Troy, T.

    2014-12-01

    As water scientists, we are increasingly handling larger and larger datasets with many variables, making it easy to lose ourselves in the details. Advanced data visualization will play an increasingly significant role in propelling the development of water science in research, economy, policy and education. It can enable analysis within research and further data scientists' understanding of behavior and processes and can potentially affect how the public, whom we often want to inform, understands our work. Unfortunately for water scientists, data visualization is approached in an ad hoc manner when a more formal methodology or understanding could potentially significantly improve both research within the academy and outreach to the public. Firstly to broaden and deepen scientific understanding, data visualization can allow for more analyzed targets to be processed simultaneously and can represent the variables effectively, finding patterns, trends and relationships; thus it can even explores the new research direction or branch of water science. Depending on visualization, we can detect and separate the pivotal and trivial influential factors more clearly to assume and abstract the original complex target system. Providing direct visual perception of the differences between observation data and prediction results of models, data visualization allows researchers to quickly examine the quality of models in water science. Secondly data visualization can also improve public awareness and perhaps influence behavior. Offering decision makers clearer perspectives of potential profits of water, data visualization can amplify the economic value of water science and also increase relevant employment rates. Providing policymakers compelling visuals of the role of water for social and natural systems, data visualization can advance the water management and legislation of water conservation. By building the publics' own data visualization through apps and games about water

  20. Advanced Subsetter Capabilities for Atmospheric Science Datasets

    NASA Astrophysics Data System (ADS)

    Baskin, W. E.; Perez, J.

    2012-12-01

    Within the last three years, the NASA Atmospheric Sciences Data Center (ASDC) has developed and deployed production provider-specific search and subset web applications for the CALIPSO, CERES, and TES missions. ASDC is now collaborating with the MOPITT science team to provide tailored subsetting for their level 2 satellite datasets leveraging the architecture of the recently deployed subsetting systems. This presentation explores the challenges encountered by the ASDC's development team and discusses solutions implemented for the following advanced subsetter capabilities: - On-the-fly conversion of subsetted HDF data granules to NetCDF - Generation of CF-Compliant subset results for non-gridded data (level2 swaths) - Parameter-specific filtering - Multi-dimensional spatial subsetting - Complex temporal subsetting (temporal filtering)

  1. How Advancements in Science are Made

    NASA Astrophysics Data System (ADS)

    Osheroff, Douglas

    2010-06-01

    How advances in science are made, and how they may come to benefit mankind at large are complex issues. The discoveries that most influence the way we think about nature seldom can be anticipated, and frequently the applications for new technologies developed to probe a specific characteristic of nature are also seldom clear, even to the inventors of these technologies. One thing is most clear: Seldom are such advances made by individuals alone. Rather, they result from the progress of the scientific community; asking questions, developing new technologies to answer those questions, and sharing their results and their ideas with others. However, there are indeed research strategies that can substantially increase the probability of oneŠs making a discovery. Professor Osheroff will illustrate some of these strategies in the context of a number of well known discoveries, including the work he did as a graduate student, for which he shared the Nobel Prize for Physics in 1996.

  2. Advanced Chemical Propulsion for Science Missions

    NASA Technical Reports Server (NTRS)

    Liou, Larry

    2008-01-01

    The advanced chemical propulsion technology area of NASA's In-Space Technology Project is investing in systems and components for increased performance and reduced cost of chemical propulsion technologies applicable to near-term science missions. Presently the primary investment in the advanced chemical propulsion technology area is in the AMBR high temperature storable bipropellant rocket engine. Scheduled to be available for flight development starting in year 2008, AMBR engine shows a 60 kg payload gain in an analysis for the Titan-Enceladus orbiter mission and a 33 percent manufacturing cost reduction over its baseline, state-of-the-art counterpart. Other technologies invested include the reliable lightweight tanks for propellant and the precision propellant management and mixture ratio control. Both technologies show significant mission benefit, can be applied to any liquid propulsion system, and upon completion of the efforts described in this paper, are at least in parts ready for flight infusion. Details of the technologies are discussed.

  3. Advanced Biotelemetry Systems for Space Life Sciences

    NASA Technical Reports Server (NTRS)

    Hines, John W.; Connolly, John P. (Technical Monitor)

    1994-01-01

    The Sensors 2000! Program at NASA-Ames Research Center is developing an Advanced Biotelemetry System (ABTS) for Space Life Sciences applications. This modular suite of instrumentation is planned to be used in operational spaceflight missions, ground-based research and development experiments, and collaborative, technology transfer and commercialization activities. The measured signals will be transmitted via radio-frequency (RF), electromagnetic or optical carriers and direct-connected leads to a remote ABTS receiver and data acquisition system for data display, storage, and transmission to Earth. Intermediate monitoring and display systems may be hand held or portable, and will allow for personalized acquisition and control of medical and physiological data.

  4. Advances and challenges in computational plasma science

    NASA Astrophysics Data System (ADS)

    Tang, W. M.

    2005-02-01

    Scientific simulation, which provides a natural bridge between theory and experiment, is an essential tool for understanding complex plasma behaviour. Recent advances in simulations of magnetically confined plasmas are reviewed in this paper, with illustrative examples, chosen from associated research areas such as microturbulence, magnetohydrodynamics and other topics. Progress has been stimulated, in particular, by the exponential growth of computer speed along with significant improvements in computer technology. The advances in both particle and fluid simulations of fine-scale turbulence and large-scale dynamics have produced increasingly good agreement between experimental observations and computational modelling. This was enabled by two key factors: (a) innovative advances in analytic and computational methods for developing reduced descriptions of physics phenomena spanning widely disparate temporal and spatial scales and (b) access to powerful new computational resources. Excellent progress has been made in developing codes for which computer run-time and problem-size scale well with the number of processors on massively parallel processors (MPPs). Examples include the effective usage of the full power of multi-teraflop (multi-trillion floating point computations per second) MPPs to produce three-dimensional, general geometry, nonlinear particle simulations that have accelerated advances in understanding the nature of turbulence self-regulation by zonal flows. These calculations, which typically utilized billions of particles for thousands of time-steps, would not have been possible without access to powerful present generation MPP computers and the associated diagnostic and visualization capabilities. In looking towards the future, the current results from advanced simulations provide great encouragement for being able to include increasingly realistic dynamics to enable deeper physics insights into plasmas in both natural and laboratory environments. This

  5. Advance Network Reservation and Provisioning for Science

    SciTech Connect

    Balman, Mehmet; Chaniotakis, Evangelos; Shoshani, Arie; Sim, Alex

    2009-07-10

    We are witnessing a new era that offers new opportunities to conduct scientific research with the help of recent advancements in computational and storage technologies. Computational intensive science spans multiple scientific domains, such as particle physics, climate modeling, and bio-informatics simulations. These large-scale applications necessitate collaborators to access very large data sets resulting from simulations performed in geographically distributed institutions. Furthermore, often scientific experimental facilities generate massive data sets that need to be transferred to validate the simulation data in remote collaborating sites. A major component needed to support these needs is the communication infrastructure which enables high performance visualization, large volume data analysis, and also provides access to computational resources. In order to provide high-speed on-demand data access between collaborating institutions, national governments support next generation research networks such as Internet 2 and ESnet (Energy Sciences Network). Delivering network-as-a-service that provides predictable performance, efficient resource utilization and better coordination between compute and storage resources is highly desirable. In this paper, we study network provisioning and advanced bandwidth reservation in ESnet for on-demand high performance data transfers. We present a novel approach for path finding in time-dependent transport networks with bandwidth guarantees. We plan to improve the current ESnet advance network reservation system, OSCARS [3], by presenting to the clients, the possible reservation options and alternatives for earliest completion time and shortest transfer duration. The Energy Sciences Network (ESnet) provides high bandwidth connections between research laboratories and academic institutions for data sharing and video/voice communication. The ESnet On-Demand Secure Circuits and Advance Reservation System (OSCARS) establishes

  6. 78 FR 49530 - Gastroenterology Regulatory Endpoints and the Advancement of Therapeutics; Public Workshop

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-14

    ... HUMAN SERVICES Food and Drug Administration Gastroenterology Regulatory Endpoints and the Advancement of... workshop entitled ``Gastroenterology Regulatory Endpoints and the Advancement of Therapeutics (GREAT II... Health. The purpose of this workshop is to provide a forum to consider issues related to endpoints...

  7. Teaching Advanced Life Sciences in an Animal Context: Agricultural Science Teacher Voices

    ERIC Educational Resources Information Center

    Balschweid, Mark; Huerta, Alexandria

    2008-01-01

    The purpose of this qualitative study was to determine agricultural science teacher comfort with a new high school Advanced Life Science: Animal course and determine their perceptions of student impact. The advanced science course is eligible for college credit. The teachers revealed they felt confident of their science background in preparation…

  8. Technologies Advance UAVs for Science, Military

    NASA Technical Reports Server (NTRS)

    2010-01-01

    A Space Act Agreement with Goddard Space Flight Center and West Virginia University enabled Aurora Flight Sciences Corporation, of Manassas, Virginia, to develop cost-effective composite manufacturing capabilities and open a facility in West Virginia. The company now employs 160 workers at the plant, tasked with crafting airframe components for the Global Hawk unmanned aerial vehicle (UAV) program. While one third of the company's workforce focuses on Global Hawk production, the rest of the company develops advanced UAV technologies that are redefining traditional approaches to unmanned aviation. Since the company's founding, Aurora s cutting-edge work has been supported with funding from NASA's Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs.

  9. Research Institute for Advanced Computer Science

    NASA Technical Reports Server (NTRS)

    Gross, Anthony R. (Technical Monitor); Leiner, Barry M.

    2000-01-01

    The Research Institute for Advanced Computer Science (RIACS) carries out basic research and technology development in computer science, in support of the National Aeronautics and Space Administration's missions. RIACS is located at the NASA Ames Research Center. It currently operates under a multiple year grant/cooperative agreement that began on October 1, 1997 and is up for renewal in the year 2002. Ames has been designated NASA's Center of Excellence in Information Technology. In this capacity, Ames is charged with the responsibility to build an Information Technology Research Program that is preeminent within NASA. RIACS serves as a bridge between NASA Ames and the academic community, and RIACS scientists and visitors work in close collaboration with NASA scientists. RIACS has the additional goal of broadening the base of researchers in these areas of importance to the nation's space and aeronautics enterprises. RIACS research focuses on the three cornerstones of information technology research necessary to meet the future challenges of NASA missions: (1) Automated Reasoning for Autonomous Systems. Techniques are being developed enabling spacecraft that will be self-guiding and self-correcting to the extent that they will require little or no human intervention. Such craft will be equipped to independently solve problems as they arise, and fulfill their missions with minimum direction from Earth; (2) Human-Centered Computing. Many NASA missions require synergy between humans and computers, with sophisticated computational aids amplifying human cognitive and perceptual abilities; (3) High Performance Computing and Networking. Advances in the performance of computing and networking continue to have major impact on a variety of NASA endeavors, ranging from modeling and simulation to data analysis of large datasets to collaborative engineering, planning and execution. In addition, RIACS collaborates with NASA scientists to apply information technology research to a

  10. Air modeling: Air dispersion models; regulatory applications and technological advances

    SciTech Connect

    Miller, M.; Liles, R.

    1995-09-01

    Air dispersion models are a useful and practical tool for both industry and regulatory agencies. They serve as tools for engineering, permitting, and regulations development. Their cost effectiveness and ease of implementation compared to ambient monitoring is perhaps their most-appealing trait. Based on the current momentum within the U.S. EPA to develop better models and contain regulatory burdens on industry, it is likely that air dispersion modeling will be a major player in future air regulatory initiatives.

  11. Joint Institute for Advancement of Flight Sciences

    NASA Technical Reports Server (NTRS)

    1998-01-01

    The Aeroacoustics Research Program is an integral part of the Joint Institute for Advancement of Flight Sciences at The George Washington University. It is affiliated with many civil, mechanical, and environmental engineering courses, particularly those that stress theory and numerical or other analytic methods in engineering. This report lists the courses presented, the names of graduate research assistants, and bibliographic information regarding publications and presentations. Three graduate degrees were awarded and the abstracts of each dissertation is included. The dissertations were as follows: "A Numerical Investigation of Thermoacoustic Oscillations", which discusses advances in the study of acoustic phenomena through the use of computational aeroacoustics. "Computation of Vortex Shedding and Radiated Sound for a Circular Cylinder: Subcritical to Transcritical Reynolds Numbers", which discusses predicting tonal noise generated by vortex shedding from a circular cylinder. And finally, "The Radiated Field Generated by a Monopole Source in a Short, Rigid, Rectangular Duct", which develops a method for modeling the acoustic field generated by a monopole source placed in a moving rectangular duct.

  12. [Regulatory science for the proper evaluation of biomarkers (overview)].

    PubMed

    Tohkin, Masahiro; Saito, Yoshiro

    2015-01-01

    New drug development (NDD) for intractable diseases such as cancer and Alzheimer's disease has been challenging in recent years because it is difficult to evaluate the therapeutic efficacy of new drugs and the response of individual patients. Thus biomarkers might be a useful tool to facilitate NDD because they can be used to evaluate accurately drug responses. Biomarkers include proteins, metabolites, and genetic targets; imaging data and can also be used in pre-clinical studies, clinical trials, and post-marketing surveillance. In pre-clinical studies, biomarkers are used as an index of the pharmacological and toxicological effects of a new drug, which may help to predict the clinical response. In clinical studies, biomarkers are widely used as an index of clinical efficacy and safety for dose-adjustment and for patient selection. In post-clinical studies, biomarkers may facilitate the evaluation of drug responses, as well as aid improvements in drug efficacy. Several points should be considered for biomarker-guided NDD. First, the clinical study design is very important and must be suitable to permit the use of the relevant biomarkers. The analytical methods should be carefully evaluated, and evidence should be provided regarding the physiological significance and relevance of the biomarker with regard to its intended use. Regulatory sciences are required to resolve these issues and bridge the gap between basic science and clinical studies that involve biomarkers. PMID:25948297

  13. Tobacco regulatory science: research to inform regulatory action at the Food and Drug Administration's Center for Tobacco Products.

    PubMed

    Ashley, David L; Backinger, Cathy L; van Bemmel, Dana M; Neveleff, Deborah J

    2014-08-01

    The U.S. Food and Drug Administration (FDA) promotes the development of regulatory science to ensure that a strong evidence base informs all of its regulatory activities related to the manufacture, marketing, and distribution of tobacco products as well as public education about tobacco product constituents and effects. Toward that end, the FDA's Center for Tobacco Products (CTP) provides funding for research studies with scientific aims that fall within its defined regulatory authority. However, given their traditional biomedical focus on basic and applied research, some researchers may not understand the principles of regulatory science or the types of studies CTP funds. The purpose of this paper is (1) to clarify the definition of regulatory science as a distinct scientific discipline, (2) to explore the role of tobacco regulatory science in order to help researchers understand the parameters and types of research that can be funded by CTP, and (3) to describe the types of research efforts that will inform the FDA's public health framework for tobacco product regulation. PMID:24638850

  14. Advanced Inverter Functions to Support High Levels of Distributed Solar: Policy and Regulatory Considerations (Brochure)

    SciTech Connect

    Not Available

    2014-11-01

    This paper explains how advanced inverter functions (sometimes called 'smart inverters') contribute to the integration of high levels of solar PV generation onto the electrical grid and covers the contributions of advanced functions to maintaining grid stability. Policy and regulatory considerations associated with the deployment of advanced inverter functions are also introduced.

  15. Making Advanced Computer Science Topics More Accessible through Interactive Technologies

    ERIC Educational Resources Information Center

    Shao, Kun; Maher, Peter

    2012-01-01

    Purpose: Teaching advanced technical concepts in a computer science program to students of different technical backgrounds presents many challenges. The purpose of this paper is to present a detailed experimental pedagogy in teaching advanced computer science topics, such as computer networking, telecommunications and data structures using…

  16. Advanced Science for Kids: Multicultural Assessment and Programming.

    ERIC Educational Resources Information Center

    Bettac, Teresa; Huckabee, Colleen; Musser, Louise; Patton, Paulette; Yates, Joyce

    1997-01-01

    Describes Advanced Science for Kids (ASK), a multicultural approach to assessment and programming for a middle school advanced science program. ASK is designed to provide alternative approaches to identification and assessment, facilitate authentic instruction and assessment, and provide minority students with academic and social support as they…

  17. The emerging science of quantitative imaging biomarkers terminology and definitions for scientific studies and regulatory submissions.

    PubMed

    Kessler, Larry G; Barnhart, Huiman X; Buckler, Andrew J; Choudhury, Kingshuk Roy; Kondratovich, Marina V; Toledano, Alicia; Guimaraes, Alexander R; Filice, Ross; Zhang, Zheng; Sullivan, Daniel C

    2015-02-01

    The development and implementation of quantitative imaging biomarkers has been hampered by the inconsistent and often incorrect use of terminology related to these markers. Sponsored by the Radiological Society of North America, an interdisciplinary group of radiologists, statisticians, physicists, and other researchers worked to develop a comprehensive terminology to serve as a foundation for quantitative imaging biomarker claims. Where possible, this working group adapted existing definitions derived from national or international standards bodies rather than invent new definitions for these terms. This terminology also serves as a foundation for the design of studies that evaluate the technical performance of quantitative imaging biomarkers and for studies of algorithms that generate the quantitative imaging biomarkers from clinical scans. This paper provides examples of research studies and quantitative imaging biomarker claims that use terminology consistent with these definitions as well as examples of the rampant confusion in this emerging field. We provide recommendations for appropriate use of quantitative imaging biomarker terminological concepts. It is hoped that this document will assist researchers and regulatory reviewers who examine quantitative imaging biomarkers and will also inform regulatory guidance. More consistent and correct use of terminology could advance regulatory science, improve clinical research, and provide better care for patients who undergo imaging studies. PMID:24919826

  18. An alternative approach to advancing resuscitation science.

    PubMed

    Kern, Karl B; Valenzuela, Terence D; Clark, Lani L; Berg, Robert A; Hilwig, Ronald W; Berg, Marc D; Otto, Charles W; Newburn, Daniel; Ewy, Gordon A

    2005-03-01

    Stagnant survival rates in out-of-hospital cardiac arrest remain a great impetus for advancing resuscitation science. International resuscitation guidelines, with all their advantages for standardizing resuscitation therapeutic protocols, can be difficult to change. A formalized evidence-based process has been adopted by the International Liason Committee on Resuscitation (ILCOR) in formulating such guidelines. Currently, randomized clinical trials are considered optimal evidence, and very few major changes in the Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care are made without such. An alternative approach is to allow externally controlled clinical trials more weight in Guideline formulation and resuscitation protocol adoption. In Tucson, Arizona (USA), the Fire Department cardiac arrest database has revealed a number of resuscitation issues. These include a poor bystander CPR rate, a lack of response to initial defibrillation after prolonged ventricular fibrillation, and substantial time without chest compressions during the resuscitation effort. A local change in our previous resuscitation protocols had been instituted based upon this historical database information. PMID:15733752

  19. Science Drivers and Technical Challenges for Advanced Magnetic Resonance

    SciTech Connect

    Mueller, Karl T.; Pruski, Marek; Washton, Nancy M.; Lipton, Andrew S.

    2013-03-07

    This report recaps the "Science Drivers and Technical Challenges for Advanced Magnetic Resonance" workshop, held in late 2011. This exploratory workshop's goal was to discuss and address challenges for the next generation of magnetic resonance experimentation. During the workshop, participants from throughout the world outlined the science drivers and instrumentation demands for high-field dynamic nuclear polarization (DNP) and associated magnetic resonance techniques, discussed barriers to their advancement, and deliberated the path forward for significant and impactful advances in the field.

  20. An Australian Science Curriculum: Competition, Advances and Retreats

    ERIC Educational Resources Information Center

    Aubusson, Peter

    2011-01-01

    Science schooling enjoys high status. Scientific capability is perceived as critical in underpinning economic success in advanced societies. Science achievement, at all levels, has become a global competition in which nations want to be seen to triumph. Governments periodically pay close attention to science education with a view to ensuring it…

  1. Environmental sciences division: Environmental regulatory update table July 1988

    SciTech Connect

    Langston, M.E.; Nikbakht, A.; Salk, M.S.

    1988-08-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  2. Advancing adverse outcome pathways for integrated toxicology and regulatory applications

    EPA Science Inventory

    Recent regulatory efforts in many countries have focused on a toxicological pathway-based vision for human health assessments relying on in vitro systems and predictive models to generate the toxicological data needed to evaluate chemical hazard. A pathway-based vision is equally...

  3. Women in science: Current advances and challenges in Belarus

    NASA Astrophysics Data System (ADS)

    Tashlykova-Bushkevich, Iya I.

    2015-12-01

    Women constitute 49% of all natural scientists in Belarus. However, fewer than 18% of Belarusian natural scientists who hold a doctor of science degree are women. The proportion of women decreases with increasing rank at universities and institutes in Belarus. Gender imbalance at the level of full professor is striking at just 17.5% women, and illuminates the vertical segregation of women in the natural sciences. This report reviews the positions of women in science in Belarus to draw out current advances and challenges encountered by female scientists in the former socialist country. New statistical data are broken down by gender and aimed at advancing the general agenda for women in science.

  4. Advanced Colloids Experiment (ACE) Science Overview

    NASA Technical Reports Server (NTRS)

    Meyer, William V.; Sicker, Ronald J.; Chiaramonte, Francis P.; Luna, Unique J.; Chaiken, Paul M.; Hollingsworth, Andrew; Secanna, Stefano; Weitz, David; Lu, Peter; Yodh, Arjun; Yunker, Peter; Lohr, Matthew; Gratale, Matthew; Lynch, Matthew; Kodger, Thomas; Piazza, Roberto; Buzzaccaro, Stefano; Cipelletti, Luca; Schall, Peter; Veen, Sandra; Wegdam, Gerhard; Lee, Chand-Soo; Choi, Chang-Hyung; Paul, Anna-Lisa; Ferl, Robert J.; Cohen, Jacob

    2013-01-01

    The Advanced Colloids Experiment is being conducted on the International Space Station (ISS) using the Light Microscopy Module (LMM) in the Fluids Integrated Rack (FIR). Work to date will be discussed and future plans and opportunities will be highlighted. The LMM is a microscope facility designed to allow scientists to process, manipulate, and characterize colloidal samples in micro-gravity where the absence of gravitational settling and particle jamming enables scientists to study such things as:a.The role that disordered and ordered-packing of spheres play in the phase diagram and equation of state of hard sphere systems,b.crystal nucleation and growth, growth instabilities, and the glass transition, c.gelation and phase separation of colloid polymer mixtures,d.crystallization of colloidal binary alloys,e.competition between crystallization and phase separation,f.effects of anisotropy and specific interactions on packing, aggregation, frustration and crystallization,g.effects of specific reversible and irreversible interactions mediated in the first case by hybridization of complementary DNA strands attached to separate colloidal particles,h.Lock and key interactions between colloids with dimples and spheres which match the size and shape of the dimples,i.finding the phase diagrams of isotropic and interacting particles,j.new techniques for complex self-assembly including scenarios for self-replication, k.critical Casimir forces,l.biology (real and model systems) in microgravity,m.etc. By adding additional microscopy capabilities to the existing LMM, NASA will increase the tools available for scientists that fly experiments on the ISS enabling scientists to observe directly what is happening at the particle level. Presently, theories are needed to bridge the gap between what is being observed (at a macroscopic level when photographing samples) with what is happening at a particle (or microscopic) level. What is happening at a microscopic level will be directly

  5. SELYE'S CONCEPT OF PLURICAUSAL DISEASES AND ITS IMPACT ON REGULATORY SCIENCE.

    PubMed

    Somogyi, Arpád

    2014-03-30

    Science assumed in recent decades an increasingly important role in the regulatory field. Regulatory science is now regarded as established specific brunch of science. A disturbing anomaly, the emergence of fraudulent data is of major concern both in the field of research and in the regulation. Hans Selye's work on stress, on several forms of pluricausal diseases and on other experimental models came into the focus of interest on the occasion of the Selye Symposium - 2013 held in May 2013 at the Hungarian Academy of Sciences in Budapest. PMID:26118246

  6. American Association for the Advancement of Science

    MedlinePlus

    ... Use Bees for Web Hosting Full Story journals_science_20160909_hmpg.jpg Latest Issue Read more news ... teaser.jpg U.S. Presidential Candidates Address 20 Key Science-Related Questions news_20140216_am14-gun-violence_teaser- ...

  7. Math-Science Bills Advance in Congress

    ERIC Educational Resources Information Center

    Hoff, David J.; Cavanagh, Sean

    2007-01-01

    Improving K-12 instruction and student achievement in mathematics and science is at the heart of separate bills intended to bolster America's economic standing that won overwhelming approval in both houses of Congress last week. The House on April 24 approved the 10,000 Teachers, 10 Million Minds Science and Math Scholarship Act by a vote of…

  8. Advanced Hindi Reader in the Social Sciences.

    ERIC Educational Resources Information Center

    Vatuk, Ved Prakash

    This reader contains 25 selections in standard Hindi by recognized authorities in the major fields of social science; namely sociology, anthropology, folklore, economics, and political science. The writings, evenly divided both in content and style, are intended to give the reader a broad perspective of Indian culture. A 128-page Hindi-English…

  9. Advances in Science and Technology Education. ICASE 1987 Yearbook.

    ERIC Educational Resources Information Center

    Holbrook, Jack, Comp.; Chisman, Dennis, Comp.

    This yearbook gathers together trends and advances in science and technology education. The articles were reproduced by ICASE to give a better insight into recent developments and to promote international communication. Short accounts on the authors are given to indicate their involvement in science and technology education and the source of their…

  10. An Advanced Reading and Writing Course for Science Students.

    ERIC Educational Resources Information Center

    Scholz, Celeste M.

    In July and August of 1980, material writers at the University of California-Los Angeles designed a course that would focus on the various reading and writing skills that science scholars would need for successful graduate study in the United States. The scholars were advanced learners of English from various science fields, and the course was to…

  11. Advances in engineering science, volume 2

    NASA Technical Reports Server (NTRS)

    1976-01-01

    Papers are presented dealing with structural dynamics; structural synthesis; and the nonlinear analysis of structures, structural members, and composite structures and materials. Applications of mathematics and computer science are included.

  12. Advances in Engineering Science, Volume 4

    NASA Technical Reports Server (NTRS)

    1976-01-01

    The following areas of flight science are discussed in detail; (1) inviscid flow, (2) viscous flow, (3) aircraft aerodynamics, (4) fluid mechanics, (5) propulsion and combustion, and (6) flight dynamics and control.

  13. The Science Advancement through Group Engagement Program: Leveling the Playing Field and Increasing Retention in Science

    ERIC Educational Resources Information Center

    Hall, Donna M.; Curtin-Soydan, Amanda J.; Canelas, Dorian A.

    2014-01-01

    How can colleges and universities keep an open gateway to the science disciplines for the least experienced first-year science students while also maintaining high standards that challenge the students with the strongest possible high school backgrounds? The Science Advancement through Group Engagement (SAGE) project targets cohorts of less…

  14. Networking Technologies Enable Advances in Earth Science

    NASA Technical Reports Server (NTRS)

    Johnson, Marjory; Freeman, Kenneth; Gilstrap, Raymond; Beck, Richard

    2004-01-01

    This paper describes an experiment to prototype a new way of conducting science by applying networking and distributed computing technologies to an Earth Science application. A combination of satellite, wireless, and terrestrial networking provided geologists at a remote field site with interactive access to supercomputer facilities at two NASA centers, thus enabling them to validate and calibrate remotely sensed geological data in near-real time. This represents a fundamental shift in the way that Earth scientists analyze remotely sensed data. In this paper we describe the experiment and the network infrastructure that enabled it, analyze the data flow during the experiment, and discuss the scientific impact of the results.

  15. Advanced Food Science and Nutrition Reference Book.

    ERIC Educational Resources Information Center

    Texas Tech Univ., Lubbock. Home Economics Curriculum Center.

    Developed with input from personnel in the industries, this reference book complements the curriculum guide for a laboratory course on the significance of nutrition in food science. The reference book is organized into 25 chapters, each beginning with essential elements and objectives. Within the text, italicized, bold-faced vocabulary terms are…

  16. Advanced Science Students' Understandings on Nature of Science in Finland

    ERIC Educational Resources Information Center

    Sormunen, Kari; Köksal, Mustafa Serdar

    2014-01-01

    Majority of NOS studies comprise of determination or assessment studies conducted with ordinary students. In order to gain further understanding on variation in NOS understandings among the students, there should be different research attempts focusing on unconventional students such as academically advanced students. The purpose of this study is…

  17. Advances and Challenges in Computational Plasma Science

    SciTech Connect

    W.M. Tang; V.S. Chan

    2005-01-03

    Scientific simulation, which provides a natural bridge between theory and experiment, is an essential tool for understanding complex plasma behavior. Recent advances in simulations of magnetically-confined plasmas are reviewed in this paper with illustrative examples chosen from associated research areas such as microturbulence, magnetohydrodynamics, and other topics. Progress has been stimulated in particular by the exponential growth of computer speed along with significant improvements in computer technology.

  18. 77 FR 59431 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing of Advance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-27

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing of Advance Notice Relating to the Clearance and Settlement of Over-the-Counter Options September 21, 2012. Pursuant to Section 19(b)(1) of the...

  19. Advances in Lunar Science and Observational Opportunities

    NASA Technical Reports Server (NTRS)

    Heldmann, Jennifer

    2012-01-01

    Lunar science is currently undergoing a renaissance as our understanding of our Moon continues to evolve given new data from multiple lunar mission and new analyses. This talk will overview NASA's recent and future lunar missions to explain the scientific questions addressed by missions such as the Lunar Reconnaissance Orbiter (LRO), Lunar Crater Observation and Sensing Satellite (LCROSS), Gravity Recovery and Interior Laboratory (Grail), Acceleration, Reconnection, Turbulence and Electrodynamics of the Moon's Interaction with the Sun (ARTEMIS), and the Lunar Atmosphere and Dust Environment Explorer (LADEE). The talk will also overview opportunities for participatory exploration whereby professional and amateur astronomers are encouraged to participate in lunar exploration in conjunction with NASA.

  20. Emerging areas of science: Recommendations for Nursing Science Education from the Council for the Advancement of Nursing Science Idea Festival.

    PubMed

    Henly, Susan J; McCarthy, Donna O; Wyman, Jean F; Heitkemper, Margaret M; Redeker, Nancy S; Titler, Marita G; McCarthy, Ann Marie; Stone, Patricia W; Moore, Shirley M; Alt-White, Anna C; Conley, Yvette P; Dunbar-Jacob, Jacqueline

    2015-01-01

    The Council for the Advancement of Nursing Science aims to "facilitate and recognize life-long nursing science career development" as an important part of its mission. In light of fast-paced advances in science and technology that are inspiring new questions and methods of investigation in the health sciences, the Council for the Advancement of Nursing Science convened the Idea Festival for Nursing Science Education and appointed the Idea Festival Advisory Committee (IFAC) to stimulate dialogue about linking PhD education with a renewed vision for preparation of the next generation of nursing scientists. Building on the 2005 National Research Council report Advancing The Nation's Health Needs and the 2010 American Association of Colleges of Nursing Position Statement on the Research-Focused Doctorate Pathways to Excellence, the IFAC specifically addressed the capacity of PhD programs to prepare nursing scientists to conduct cutting-edge research in the following key emerging and priority areas of health sciences research: omics and the microbiome; health behavior, behavior change, and biobehavioral science; patient-reported outcomes; big data, e-science, and informatics; quantitative sciences; translation science; and health economics. The purpose of this article is to (a) describe IFAC activities, (b) summarize 2014 discussions hosted as part of the Idea Festival, and (c) present IFAC recommendations for incorporating these emerging areas of science and technology into research-focused doctoral programs committed to preparing graduates for lifelong, competitive careers in nursing science. The recommendations address clearer articulation of program focus areas; inclusion of foundational knowledge in emerging areas of science in core courses on nursing science and research methods; faculty composition; prerequisite student knowledge and skills; and in-depth, interdisciplinary training in supporting area of science content and methods. PMID:26187079

  1. Jansky Very Large Array: technology advancing science

    NASA Astrophysics Data System (ADS)

    Carilli, Christopher

    2015-08-01

    Over the last decade, the NRAO has completed on time, and on budget, a major reconstruction of the Very Large Array. Building on existing infrastructure to maximize efficiency, the entire VLA electronics system, including correlator, receivers, data transmission, and monitor and control, have been replaced with state of the art systems. This complete rebuild establishes the new Jansky VLA, operating between 75MHz and 50GHz, as the most powerful radio telescope in the world for the coming decade.I will review the technical improvements of the array, including:- Correlator: Increased bandwidth from 100MHz to 8GHz, with thousands of spectral channels.- Receivers: replaced the previous narrow bands with receivers covering the full frequency range from 1 GHz to 50GHz. New systems are also being tested to cover from 50MHz to 400MHz.- Data transmission: 8GHz over optical fiber out to 30km.I will then highlight some of the science enabled by these improvements, including:- Large cosmic volume searches for atomic and molecular gas, from the nearby Universe to the most distant galaxies, plus kpc-scale imaging of the cool gas in distant starburst galaxies.- High resolution studies of star and planet formation.- Innovative interferometric searches for transient phenomena.- The first radio continuum deep fields with sensitivities < 1uJy, with full polarization for Faraday tomography.- Imaging radio-mode feedback in galaxies and clusters, and delineating the complex plasma physical processes involved on scales from a few kpc to hundreds of kpc.I will conclude with a few words about the major challenges facing such a new instrument. These challenges are all on the critical path toward any successful development of future facilities, such as the next generation VLA and SKA:- Big data: data volumes and post-processing are currently major bottlenecks in the turn-over from observation to science publication. NRAO is developing calibration and imaging pipelines to provide science

  2. Advances in SPICE Support of Planetary Science

    NASA Technical Reports Server (NTRS)

    Acton, C. H.

    2013-01-01

    SPICE is the de facto international standard for determining the geometric conditions-parameters such as altitude, lighting angles, and LAT/LON coverage of an instrument footprint-pertaining to scientific observations acquired by instruments on board robotic spacecraft. This system, comprised of data and allied software, is used for planning science observations and for analyzing the data returned from those observations. Use of SPICE is not a NASA requirement but is recommended by NASA's Planetary Data System and by the International Planetary Data Alliance. Owing in part to its reliability, stability, portability and user support, the use of SPICE has spread to many national space agencies, including those of the U.S., Europe (ESA), Japan, Russia and India. SPICE has been in use since the Magellan mission to Venus and so has many well-known capabilities. But the NAIF Team responsible for implementing SPICE continues to add new features; this presentation describes a number of these.

  3. Automated sensor networks to advance ocean science

    NASA Astrophysics Data System (ADS)

    Schofield, O.; Orcutt, J. A.; Arrott, M.; Vernon, F. L.; Peach, C. L.; Meisinger, M.; Krueger, I.; Kleinert, J.; Chao, Y.; Chien, S.; Thompson, D. R.; Chave, A. D.; Balasuriya, A.

    2010-12-01

    The National Science Foundation has funded the Ocean Observatories Initiative (OOI), which over the next five years will deploy infrastructure to expand scientist’s ability to remotely study the ocean. The deployed infrastructure will be linked by a robust cyberinfrastructure (CI) that will integrate marine observatories into a coherent system-of-systems. OOI is committed to engaging the ocean sciences community during the construction pahse. For the CI, this is being enabled by using a “spiral design strategy” allowing for input throughout the construction phase. In Fall 2009, the OOI CI development team used an existing ocean observing network in the Mid-Atlantic Bight (MAB) to test OOI CI software. The objective of this CI test was to aggregate data from ships, autonomous underwater vehicles (AUVs), shore-based radars, and satellites and make it available to five different data-assimilating ocean forecast models. Scientists used these multi-model forecasts to automate future glider missions in order to demonstrate the feasibility of two-way interactivity between the sensor web and predictive models. The CI software coordinated and prioritized the shared resources that allowed for the semi-automated reconfiguration of assett-tasking, and thus enabled an autonomous execution of observation plans for the fixed and mobile observation platforms. Efforts were coordinated through a web portal that provided an access point for the observational data and model forecasts. Researchers could use the CI software in tandem with the web data portal to assess the performance of individual numerical model results, or multi-model ensembles, through real-time comparisons with satellite, shore-based radar, and in situ robotic measurements. The resulting sensor net will enable a new means to explore and study the world’s oceans by providing scientists a responsive network in the world’s oceans that can be accessed via any wireless network.

  4. Recent advances in fullerene science (Invited)

    SciTech Connect

    Dunk, P. W.; Marshall, A. G.; Mulet-Gas, M.; Rodriguez-Fortea, A.; Poblet, J. M.

    2014-12-09

    The development of very high resolution FT-ICR mass spectrometers (Marshall et al, 1998) has made a wide range of new measurements possible and by combining this new technology with laser vaporization supersonic beam methods of producing carbon species (chains, rings and fullerenes), new advances in understanding of the fullerene creation mechanisms and their reactivity have been possible. In this overview, new understanding has been developed with regard to: a) closed-network growth of fullerenes (Dunk et al, 2012a); b) small endohedral species such as MαC{sub 28} (Dunk et al., 2012b); c) metallofullerene and fullerene formation under conditions in stellar outflows with relevance to stardust (Dunk et al., 2013a) and d) The formation of heterofullerenes by direct exposure of C{sub 60} toboron vapor (Dunk et al., 2013b)

  5. Joint Institute for Advancement of Flight Sciences

    NASA Technical Reports Server (NTRS)

    1998-01-01

    The program objectives were defined in the original proposal entitled "Program of Research in Flight Dynamics in the JIAFS at NASA Langley Research Center" which was originated March 20, 1975, and in yearly renewals of the research program dated December 1, 1979 to December 1, 1998. The program included three major topics: 1) Improvement of existing methods and development of new methods for flight and wind tunnel data analysis based on system identification methodology. 2) Application of these methods to flight and wind tunnel data obtained from advanced aircraft. 3) Modeling and control of aircraft, space structures and spacecraft. The principal investigator of the program was Dr. Vladislav Klein, Professor at The George Washington University, Washington, D.C.. Thirty-seven Graduate Research Scholar Assistants, two of them doctoral students, also participated in the program. The results of the research conducted during nineteen years of the total co-operative period were published in 23 NASA technical reports, 2 D.Sc. Dissertations, 14 M.S. Theses and 33 papers. The list of these publications is included. The results were also reported in more than 30 seminar lectures presented at various research establishments world-wide. For contributions to the research supported by the co-operative agreement, three NASA Awards were received: 1) NASA LARC Group Achievement Award, May 30, 1990, to Dr. V. Klein as a member of the X-29 Drop Model Team. 2) NASA Medal for Exceptional Engineering Achievement, March 27, 1992, to Dr. V. Klein for innovative contributions in the development of advanced techniques and computer programs in the field of system identification. 3) NASA LaRC Team Excellence Award, May 7, 1994, to Dr. V. Klein as a member of the X-31 Drop Model Team.

  6. The Advanced Communications Technology Satellite (ACTS) capabilities for serving science

    NASA Technical Reports Server (NTRS)

    Meyer, Thomas R.

    1990-01-01

    Results of research on potential science applications of the NASA Advanced Communications Technology Satellite (ACTS) are presented. Discussed here are: (1) general research on communications related issues; (2) a survey of science-related activities and programs in the local area; (3) interviews of selected scientists and associated telecommunications support personnel whose projects have communications requirements; (4) analysis of linkages between ACTS functionality and science user communications activities and modes of operation; and (5) an analysis of survey results and the projection of conclusions to a national scale.

  7. The Effect of Explicit Embedded Reflective Instruction on Nature of Science Understandings in Advanced Science Students

    ERIC Educational Resources Information Center

    Koksal, Mustafa Serdar; Cakiroglu, Jale; Geban, Omer

    2013-01-01

    The purpose of this study is to investigate the effectiveness of explicit-embedded-reflective (EER) instruction in nature of science (NOS) understandings of ninth-grade advanced science students. This study was conducted with 71 students, who were divided into three groups, by using non-equivalent quasi-experimental design. In the treatment…

  8. Applied Developmental Science: An Advanced Textbook. The SAGE Program on Applied Developmental Science

    ERIC Educational Resources Information Center

    Lerner, Richard M., Ed.; Jacobs, Fraincine, Ed.; Wertlieb, Donald, Ed.

    2005-01-01

    This course textbook has been adapted from the four-volume "Handbook of Applied Developmental Science" (SAGE 2003), a work that offers a detailed roadmap for action and research in ensuring positive child, youth, and family development. In 20 chapters, "Applied Developmental Science: An Advanced Textbook" brings together theory and application…

  9. Decisions, Science, and Values: Crafting Regulatory Alternatives Analysis.

    PubMed

    Malloy, Timothy; Blake, Ann; Linkov, Igor; Sinsheimer, Peter

    2015-12-01

    Emerging "prevention-based" approaches to chemical regulation seek to minimize the use of toxic chemicals by mandating or directly incentivizing the adoption of viable safer alternative chemicals or processes. California and Maine are beginning to implement such programs, requiring manufacturers of consumer products containing certain chemicals of concern to identify and evaluate potential safer alternatives. In the European Union, the REACH program imposes similar obligations on manufacturers of certain substances of very high concern. Effective prevention-based regulation requires regulatory alternatives analysis (RAA), a methodology for comparing and evaluating the regulated chemical or process and its alternatives across a range of relevant criteria. RAA has both public and private dimensions. To a significant degree, alternatives analysis is an aspect of product design; that is, the process by which private industry designs the goods it sells. Accordingly, an RAA method should reflect the attributes of well-crafted product design tools used by businesses. But RAA adds health and environmental objectives to the mix of concerns taken into account by the product designer. Moreover, as part of a prevention-based regulatory regime, it implicates important public values such as legitimacy, equity, public engagement, and accountability. Thus, an RAA should reflect both private standards and public values, and be evaluated against them. This article adopts that perspective, identifying an integrated set of design principles for RAA, and illustrating the application of those principles. PMID:26299695

  10. Regulatory Advances in 11 Sub-Saharan Countries in Year 3 of the African Health Profession Regulatory Collaborative for Nurses and Midwives (ARC).

    PubMed

    Dynes, Michelle; Tison, Laura; Johnson, Carla; Verani, Andre; Zuber, Alexandra; Riley, Patricia L

    2016-01-01

    Sub-Saharan Africa carries the greatest burden of the HIV pandemic. Enhancing the supply and use of human resources through policy and regulatory reform is a key action needed to improve the quality of HIV services in this region. In year 3 of the African Health Profession Regulatory Collaborative for Nurses and Midwives (ARC), a President's Emergency Plan for AIDS Relief initiative, 11 country teams of nursing and midwifery leaders ("Quads") received small grants to carry out regulatory improvement projects. Four countries advanced a full stage on the Regulatory Function Framework (RFF), a staged capability maturity model used to evaluate progress in key regulatory functions. While the remaining countries did not advance a full stage on the RFF, important gains were noted. The year-3 evaluation highlighted limitations of the ARC evaluation strategy to capture nuanced progress and provided insight into how the RFF might be adapted for future use. PMID:27086189

  11. Regulatory Advances in 11 Sub-Saharan Countries in Year 3 of the African Health Profession Regulatory Collaborative for Nurses and Midwives (ARC)

    PubMed Central

    Dynes, Michelle; Tison, Laura; Johnson, Carla; Verani, Andre; Zuber, Alexandra; Riley, Patricia L.

    2016-01-01

    Sub-Saharan Africa carries the greatest burden of the HIV pandemic. Enhancing the supply and use of human resources through policy and regulatory reform is a key action needed to improve the quality of HIV services in this region. In year 3 of the African Health Profession Regulatory Collaborative for Nurses and Midwives (ARC), a President’s Emergency Plan for AIDS Relief initiative, 11 country teams of nursing and midwifery leaders (“Quads”) received small grants to carry out regulatory improvement projects. Four countries advanced a full stage on the Regulatory Function Framework (RFF), a staged capability maturity model used to evaluate progress in key regulatory functions. While the remaining countries did not advance a full stage on the RFF, important gains were noted. The year-3 evaluation highlighted limitations of the ARC evaluation strategy to capture nuanced progress and provided insight into how the RFF might be adapted for future use. PMID:27086189

  12. Who Succeeds in Advanced Mathematics and Science Courses?

    ERIC Educational Resources Information Center

    Korpershoek, Hanke; Kuyper, Hans; van der Werf, Greetje; Bosker, Roel

    2011-01-01

    Few students (particularly few girls) currently choose to take their Final School Examination (FSE) in advanced mathematics, chemistry and physics, a combination of subjects that is the best preparation for a science-oriented study in higher education. Are these subjects attainable by more students than is currently the case? This study examined…

  13. Science and Decisions: Advancing Risk Assessment (NAS Final Report)

    EPA Science Inventory

    In August 2009, the Committee on Improving Risk Analysis Approaches Used by the U.S. EPA, National Research Council released a final report, requested and sponsored by the EPA, entitled Science and Decisions: Advancing Risk Assessment 2009.

  14. Air Quality Science and Regulatory Efforts Require Geostationary Satellite Measurements

    NASA Technical Reports Server (NTRS)

    Pickering, Kenneth E.; Allen, D. J.; Stehr, J. W.

    2006-01-01

    Air quality scientists and regulatory agencies would benefit from the high spatial and temporal resolution trace gas and aerosol data that could be provided by instruments on a geostationary platform. More detailed time-resolved data from a geostationary platform could be used in tracking regional transport and in evaluating mesoscale air quality model performance in terms of photochemical evolution throughout the day. The diurnal cycle of photochemical pollutants is currently missing from the data provided by the current generation of atmospheric chemistry satellites which provide only one measurement per day. Often peak surface ozone mixing ratios are reached much earlier in the day during major regional pollution episodes than during local episodes due to downward mixing of ozone that had been transported above the boundary layer overnight. The regional air quality models often do not simulate this downward mixing well enough and underestimate surface ozone in regional episodes. Having high time-resolution geostationary data will make it possible to determine the magnitude of this lower-and mid-tropospheric transport that contributes to peak eight-hour average ozone and 24-hour average PM2.5 concentrations. We will show ozone and PM(sub 2.5) episodes from the CMAQ model and suggest ways in which geostationary satellite data would improve air quality forecasting. Current regulatory modeling is typically being performed at 12 km horizontal resolution. State and regional air quality regulators in regions with complex topography and/or land-sea breezes are anxious to move to 4-km or finer resolution simulations. Geostationary data at these or finer resolutions will be useful in evaluating such models.

  15. Precipitation from Space: Advancing Earth System Science

    NASA Technical Reports Server (NTRS)

    Kucera, Paul A.; Ebert, Elizabeth E.; Turk, F. Joseph; Levizzani, Vicenzo; Kirschbaum, Dalia; Tapiador, Francisco J.; Loew, Alexander; Borsche, M.

    2012-01-01

    Of the three primary sources of spatially contiguous precipitation observations (surface networks, ground-based radar, and satellite-based radar/radiometers), only the last is a viable source over ocean and much of the Earth's land. As recently as 15 years ago, users needing quantitative detail of precipitation on anything under a monthly time scale relied upon products derived from geostationary satellite thermal infrared (IR) indices. The Special Sensor Microwave Imager (SSMI) passive microwave (PMW) imagers originated in 1987 and continue today with the SSMI sounder (SSMIS) sensor. The fortunate longevity of the joint National Aeronautics and Space Administration (NASA) and Japan Aerospace Exploration Agency (JAXA) Tropical Rainfall Measuring Mission (TRMM) is providing the environmental science community a nearly unbroken data record (as of April 2012, over 14 years) of tropical and sub-tropical precipitation processes. TRMM was originally conceived in the mid-1980s as a climate mission with relatively modest goals, including monthly averaged precipitation. TRMM data were quickly exploited for model data assimilation and, beginning in 1999 with the availability of near real time data, for tropical cyclone warnings. To overcome the intermittently spaced revisit from these and other low Earth-orbiting satellites, many methods to merge PMW-based precipitation data and geostationary satellite observations have been developed, such as the TRMM Multisatellite Precipitation Product and the Climate Prediction Center (CPC) morphing method (CMORPH. The purpose of this article is not to provide a survey or assessment of these and other satellite-based precipitation datasets, which are well summarized in several recent articles. Rather, the intent is to demonstrate how the availability and continuity of satellite-based precipitation data records is transforming the ways that scientific and societal issues related to precipitation are addressed, in ways that would not be

  16. In Vitro Testing for Orally Inhaled Products: Developments in Science-Based Regulatory Approaches.

    PubMed

    Forbes, Ben; Bäckman, Per; Christopher, David; Dolovich, Myrna; Li, Bing V; Morgan, Beth

    2015-07-01

    This article is part of a series of reports from the "Orlando Inhalation Conference-Approaches in International Regulation" which was held in March 2014, and coorganized by the University of Florida and the International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS). The goal of the conference was to foster the exchange of ideas and knowledge across the global scientific and regulatory community in order to identify and help move towards strategies for internationally harmonized, science-based regulatory approaches for the development and marketing approval of inhalation medicines, including innovator and second entry products. This article provides an integrated perspective of case studies and discussion related to in vitro testing of orally inhaled products, including in vitro-in vivo correlations and requirements for in vitro data and statistical analysis that support quality or bioequivalence for regulatory applications. PMID:25940082

  17. Women's Science Major Satisfaction: Regulatory Focus and the Critical Mass Hypothesis

    ERIC Educational Resources Information Center

    Deemer, Eric D.

    2015-01-01

    Women contend with gender bias in certain science contexts, which suggests they may be likely to adopt prevention-focused modes of regulation aimed at maintaining safety and security in such settings. This study represented an integrated test of regulatory focus theory (RFT; Higgins, 1997, 1998) and the critical mass hypothesis, which assumes that…

  18. Advanced X-ray Astrophysics Facility (AXAF) science instrumentation

    NASA Technical Reports Server (NTRS)

    Dailey, C. C.; Cumings, N. P.; Winkler, C. E.

    1985-01-01

    AXAF is to be equipped with a high performance X-ray telescope for the conduction of detailed astrophysics research. The observatory is to be serviced by the Space Station or the Shuttle, depending on capabilities during the AXAF operational period. The AXAF is to utilize the wavelength band from 1.2 A to 120 A. Attention is given to the AXAF science team, the AXAF observatory characteristics, the AXAF science instrument definition program, the Advanced Charge Coupled Device (CCD) Imaging Spectrometer (ACIS), the High Resolution Camera (HRC), the Bragg Crystal Spectrometer (BCS), the X-ray Spectrometer (XRS), the transmission gratings, and the program schedule.

  19. Center for Advanced Signal and Imaging Sciences Workshop 2004

    SciTech Connect

    McClellan, J H; Carrano, C; Poyneer, L; Palmer, D; Baker, K; Chen, D; London, R; Weinert, G; Brase, J; Paglieroni, D; Lopez, A; Grant, C W; Wright, W; Burke, M; Miller, W O; DeTeresa, S; White, D; Toeppen, J; Haugen, P; Kamath, C; Nguyen, T; Manay, S; Newsam, S; Cantu-Paz, E; Pao, H; Chang, J; Chambers, D; Leach, R; Paulson, C; Romero, C E; Spiridon, A; Vigars, M; Welsh, P; Zumstein, J; Romero, K; Oppenheim, A; Harris, D B; Dowla, F; Brown, C G; Clark, G A; Ong, M M; Clance, T J; Kegelmeyer, l M; Benzuijen, M; Bliss, E; Burkhart, S; Conder, A; Daveler, S; Ferguson, W; Glenn, S; Liebman, J; Norton, M; Prasad, R; Salmon, T; Kegelmeyer, L M; Hafiz, O; Cheung, S; Fodor, I; Aufderheide, M B; Bary, A; Martz, Jr., H E; Burke, M W; Benson, S; Fisher, K A; Quarry, M J

    2004-11-15

    Welcome to the Eleventh Annual C.A.S.I.S. Workshop, a yearly event at the Lawrence Livermore National Laboratory, presented by the Center for Advanced Signal & Image Sciences, or CASIS, and sponsored by the LLNL Engineering Directorate. Every November for the last 10 years we have convened a diverse set of engineering and scientific talent to share their work in signal processing, imaging, communications, controls, along with associated fields of mathematics, statistics, and computing sciences. This year is no exception, with sessions in Adaptive Optics, Applied Imaging, Scientific Data Mining, Electromagnetic Image and Signal Processing, Applied Signal Processing, National Ignition Facility (NIF) Imaging, and Nondestructive Characterization.

  20. Advancing the Science of Community-Level Interventions

    PubMed Central

    Beehler, Sarah; Deutsch, Charles; Green, Lawrence W.; Hawe, Penelope; McLeroy, Kenneth; Miller, Robin Lin; Rapkin, Bruce D.; Schensul, Jean J.; Schulz, Amy J.; Trimble, Joseph E.

    2011-01-01

    Community interventions are complex social processes that need to move beyond single interventions and outcomes at individual levels of short-term change. A scientific paradigm is emerging that supports collaborative, multilevel, culturally situated community interventions aimed at creating sustainable community-level impact. This paradigm is rooted in a deep history of ecological and collaborative thinking across public health, psychology, anthropology, and other fields of social science. The new paradigm makes a number of primary assertions that affect conceptualization of health issues, intervention design, and intervention evaluation. To elaborate the paradigm and advance the science of community intervention, we offer suggestions for promoting a scientific agenda, developing collaborations among professionals and communities, and examining the culture of science. PMID:21680923

  1. Advances in Parallel Electromagnetic Codes for Accelerator Science and Development

    SciTech Connect

    Ko, Kwok; Candel, Arno; Ge, Lixin; Kabel, Andreas; Lee, Rich; Li, Zenghai; Ng, Cho; Rawat, Vineet; Schussman, Greg; Xiao, Liling; /SLAC

    2011-02-07

    Over a decade of concerted effort in code development for accelerator applications has resulted in a new set of electromagnetic codes which are based on higher-order finite elements for superior geometry fidelity and better solution accuracy. SLAC's ACE3P code suite is designed to harness the power of massively parallel computers to tackle large complex problems with the increased memory and solve them at greater speed. The US DOE supports the computational science R&D under the SciDAC project to improve the scalability of ACE3P, and provides the high performance computing resources needed for the applications. This paper summarizes the advances in the ACE3P set of codes, explains the capabilities of the modules, and presents results from selected applications covering a range of problems in accelerator science and development important to the Office of Science.

  2. Individuals and Institutions : How to Advance Women in Science

    NASA Astrophysics Data System (ADS)

    Valian, Virginia

    2015-01-01

    The inception of the NSF ADVANCE program marked a change in NSF's efforts to improve the advancement of women in the sciences. Previous efforts had focused on providing women with funding to pursue their research. ADVANCE focuses on changing the institutions in which women do their research. Evidence of ADVANCE's successes can be seen both in the careers of individual women and in hiring and retention figures at the institutions that received funding. In Part 1, I will review interventions that help women to succeed, with a focus on the Sponsorship Program and the Workshop Series for Junior Faculty that the Gender Equity Project at Hunter College developed. In Part 2, I will review successes in changing hiring practices, with a focus on ADVANCE programs from the University of Michigan and the University of Wisconsin. In Part 3, I will analyze the costs and benefits of the two types of intervention, including the long time course of institutional change, the helpful or hurtful role that leaders can play, the need for intervention at the departmental level, and the potential for individuals to change institutions.

  3. Activities of the Research Institute for Advanced Computer Science

    NASA Technical Reports Server (NTRS)

    Oliger, Joseph

    1994-01-01

    The Research Institute for Advanced Computer Science (RIACS) was established by the Universities Space Research Association (USRA) at the NASA Ames Research Center (ARC) on June 6, 1983. RIACS is privately operated by USRA, a consortium of universities with research programs in the aerospace sciences, under contract with NASA. The primary mission of RIACS is to provide research and expertise in computer science and scientific computing to support the scientific missions of NASA ARC. The research carried out at RIACS must change its emphasis from year to year in response to NASA ARC's changing needs and technological opportunities. Research at RIACS is currently being done in the following areas: (1) parallel computing; (2) advanced methods for scientific computing; (3) high performance networks; and (4) learning systems. RIACS technical reports are usually preprints of manuscripts that have been submitted to research journals or conference proceedings. A list of these reports for the period January 1, 1994 through December 31, 1994 is in the Reports and Abstracts section of this report.

  4. Recent Advances in Infrasound Science for National Security Applications

    NASA Astrophysics Data System (ADS)

    Arrowsmith, S.; Blom, P. S.; Marcillo, O. E.; Whitaker, R. W.

    2014-12-01

    Infrasound is sound below the frequency-threshold of human hearing, covering the frequency range from 0.01 - 20 Hz. Infrasound science studies the generation, propagation, measurement, and analysis of infrasound. Sources of infrasound include a wide variety of energetic natural and manmade phenomena that include chemical and nuclear explosions, rockets and missiles, and aircraft. The dominant factors influencing the propagation of infrasound are the spatial and temporal variations in temperature, wind speed, and wind direction. In recent years, Infrasound Science has experienced a renaissance due to the installation of an international monitoring system of 60 infrasound arrays for monitoring the Comprehensive Nuclear Test Ban Treaty, and to the demonstrated value of regional infrasound networks for both scientific and applied purposes. Furthermore, in the past decade, significant advances have been made on using measurements of infrasound to invert for these properties of the atmosphere at altitudes where alternative measurement techniques are extremely costly. This presentation provides a review of recent advances in infrasound science as relevant to National Security applications.

  5. Application of the LBB regulatory approach to the steamlines of advanced WWER 1000 reactor

    SciTech Connect

    Kiselyov, V.A.; Sokov, L.M.

    1997-04-01

    The LBB regulatory approach adopted in Russia in 1993 as an extra safety barrier is described for advanced WWER 1000 reactor steamline. The application of LBB concept requires the following additional protections. First, the steamline should be a highly qualified piping, performed in accordance with the applicable regulations and guidelines, carefully screened to verify that it is not subjected to any disqualifying failure mechanism. Second, a deterministic fracture mechanics analysis and leak rate evaluation have been performed to demonstrate that postulated through-wall crack that yields 95 1/min at normal operation conditions is stable even under seismic loads. Finally, it has been verified that the leak detection systems are sufficiently reliable, diverse and sensitive, and that adequate margins exist to detect a through wall crack smaller than the critical size. The obtained results are encouraging and show the possibility of the application of the LBB case to the steamline of advanced WWER 1000 reactor.

  6. Science and Technology to Advance Regional Security in Central Asia

    SciTech Connect

    Rosenberg, N

    2002-07-05

    This morning I will describe a program that we refer to as STARS, for Science and Technology to Advance Regional Security, in Central Asia. It is a program that is based on cooperative, bilateral and multilateral, science and technology projects. It is our premise that such cooperative projects provide an opportunity for engagement while addressing real problems that could otherwise lead to destabilizing tensions in the region. The STARS program directly supports USCENTCOM's activities and objectives in environmental security. In fact, we think that STARS is a great vehicle for implementing and amplifying USCENTCOM's environmental security objectives and activities. We are very grateful and very pleased to have General DeLong's support in this matter. I am going to briefly describe the program. I want to stress again that it is a cooperative program. We would like to get input, suggestions, and feedback from the Central Asians here today so we can move forward together.

  7. Advanced data products for the JCMT Science Archive

    NASA Astrophysics Data System (ADS)

    Bell, Graham S.; Graves, Sarah F.; Currie, Malcolm J.; Berry, David S.; Parsons, Harriet; Jenness, Timothy; Redman, Russell O.; Dempsey, Jessica T.; Johnstone, Doug; Economou, Frossie

    2014-07-01

    The JCMT Science Archive is a collaboration between the James Clerk Maxwell Telescope and the Canadian Astronomy Data Centre to provide access to raw and reduced data from SCUBA-2 and the telescope's heterodyne instruments. It was designed to include a range of advanced data products, created either by external groups, such as the JCMT Legacy Survey teams, or by the JCMT staff at the Joint Astronomy Centre. We are currently developing the archive to include a set of advanced data products which combine all of the publicly available data. We have developed a sky tiling scheme based on HEALPix tiles to allow us to construct co-added maps and data cubes on a well-defined grid. There will also be source catalogs both of regions of extended emission and the compact sources detected within these regions.

  8. The Advanced Superconducting Test Accelerator at Fermilab: Science Program

    SciTech Connect

    Piot, Philippe; Harms, Elvin; Henderson, Stuart; Leibfritz, Jerry; Nagaitsev, Sergei; Shiltsev, Vladimir; Valishev, Alexander

    2014-07-01

    The Advanced Superconducting Test Accelerator (ASTA) currently in commissioning phase at Fermilab is foreseen to support a broad range of beam-based experiments to study fundamental limitations to beam intensity and to develop novel approaches to particle-beam generation, acceleration and manipulation. ASTA incorporates a superconducting radiofrequency (SCRF) linac coupled to a flexible high-brightness photoinjector. The facility also includes a small-circumference storage ring capable of storing electrons or protons. This report summarizes the facility capabilities, and provide an overview of the accelerator-science researches to be enabled.

  9. The Effect of Background Experience and an Advance Organizer on the Attainment of Certain Science Concepts.

    ERIC Educational Resources Information Center

    McAdaragh, Mary Kathleen

    This study examined the effects of an advance organizer and background experience in science on the attainment of science concepts. Ninth-grade earth science students (N=90) were given the Dubbins Earth Science Test (DEST) and a Science Background Experience Inventory (SBEI) developed by the author. They were then placed into high, medium, and low…

  10. Advanced Hydrologic Prediction Services (AHPS) Science Infusion Strategy

    NASA Astrophysics Data System (ADS)

    Schaake, J.; Smith, G.; Carter, G.

    2002-05-01

    NWS is implementing an Advanced Hydrologic Prediction Services (AHPS) Science initiative to meet NWS Vision 2005 goals and related hydrologic services requirements, including the goal of being a world leader using state of the art forecast science and technology. AHPS includes a science infusion strategy to meet the following objectives: extend forecast lead time, improve forecast accuracy, and provide better information for user decisions. AHPS will meet these goals by implementing hydrologic forecast models tuned to local conditions and operated to account for uncertainty in hydrologic forecasts. AHPS will use ensemble weather and climate forecasts of precipitation and other conditions, such as air temperature, that affect the forecasts. This ensemble approach to weather, climate and water forecasting will provide a probabilistic basis for AHPS forecast products. Meeting AHPS goals and objectives requires an infusion of new science into the existing forecast system. Three AHPS requirements for science infusion are: 1. Quantify the uncertainty of river forecasts and provide users with a clear view of future hydrologic conditions together with hard evidence that AHPS products are based on valid forecast probability information; 2. Reduce the space and time scale, improve the accuracy, and extend the lead time of hydrologic forecasts. Demonstrate that new improvements to hydrologic forecast procedures add value to the forecasts and meet user requirements; 3. Improve the ability of forecasters to use the tools provided by integrating these into an efficient operational forecast system that includes automatic techniques for data quality control, access to data, model calibration, data assimilation, processing of ensemble forecasts, verification of forecasts and monitoring of all stages of the forecast process.

  11. Simulated Interactive Research Experiments as Educational Tools for Advanced Science

    NASA Astrophysics Data System (ADS)

    Tomandl, Mathias; Mieling, Thomas; Losert-Valiente Kroon, Christiane M.; Hopf, Martin; Arndt, Markus

    2015-09-01

    Experimental research has become complex and thus a challenge to science education. Only very few students can typically be trained on advanced scientific equipment. It is therefore important to find new tools that allow all students to acquire laboratory skills individually and independent of where they are located. In a design-based research process we have investigated the feasibility of using a virtual laboratory as a photo-realistic and scientifically valid representation of advanced scientific infrastructure to teach modern experimental science, here, molecular quantum optics. We found a concept based on three educational principles that allows undergraduate students to become acquainted with procedures and concepts of a modern research field. We find a significant increase in student understanding using our Simulated Interactive Research Experiment (SiReX), by evaluating the learning outcomes with semi-structured interviews in a pre/post design. This suggests that this concept of an educational tool can be generalized to disseminate findings in other fields.

  12. Simulated Interactive Research Experiments as Educational Tools for Advanced Science.

    PubMed

    Tomandl, Mathias; Mieling, Thomas; Losert-Valiente Kroon, Christiane M; Hopf, Martin; Arndt, Markus

    2015-01-01

    Experimental research has become complex and thus a challenge to science education. Only very few students can typically be trained on advanced scientific equipment. It is therefore important to find new tools that allow all students to acquire laboratory skills individually and independent of where they are located. In a design-based research process we have investigated the feasibility of using a virtual laboratory as a photo-realistic and scientifically valid representation of advanced scientific infrastructure to teach modern experimental science, here, molecular quantum optics. We found a concept based on three educational principles that allows undergraduate students to become acquainted with procedures and concepts of a modern research field. We find a significant increase in student understanding using our Simulated Interactive Research Experiment (SiReX), by evaluating the learning outcomes with semi-structured interviews in a pre/post design. This suggests that this concept of an educational tool can be generalized to disseminate findings in other fields. PMID:26370627

  13. MIDAS: Advanced Remote Sensing for Planetary Science and Exploration

    NASA Astrophysics Data System (ADS)

    Delory, G. T.; de Pater, I.; Manga, M.; Lipps, J.; Dalton, J.; Pitman, J.; UCB CIPS Collaboration; MIDAS Team

    2005-12-01

    The Multiple Instrument Distributed Aperture Sensor (MIDAS) is a revolutionary approach to planetary remote sensing. The integration of optical interferometric techniques and distributed aperture technology enables MIDAS to perform as a diffraction-limited, wide-field imaging spectrometer with simultaneous high spatial and spectral resolution. Here we describe the results of a science and technical feasibility study of MIDAS prototypes funded under the NASA High Capability Instrument Concepts and Technology (HCICT) program as a potential science payload for missions to the outer planets and their moons. Activities include testbed demonstrations in the lab during which the spatial and spectral capabilities of MIDAS-derived approaches have been explored, using both source imagery and materials relevant to outer planet environments. The high spatial resolution capabilities of MIDAS combined with nm spectral resolution will greatly advance our understanding of surface composition in terms of minerals, organics, volatiles, and their mixtures. Utilizing cm scale spatial resolution in the visible from a 100 km orbit, features such as crack movements and other indicators of tidal forcing could be resolved on the surface of Europa. At higher altitudes MIDAS engages in global, high resolution imaging spectroscopy with meter-scale resolution. Beyond traditional remote sensing, MIDAS is well suited to active techniques including remote Raman, Flourescence, and IR illumination investigations in order to resolve surface composition and explore otherwise dim regions. Other applications for MIDAS include remote sensing measurements on the Moon and Mars, where orders of magnitude advances beyond the resolutions of current data sets are possible.

  14. Simulated Interactive Research Experiments as Educational Tools for Advanced Science

    PubMed Central

    Tomandl, Mathias; Mieling, Thomas; Losert-Valiente Kroon, Christiane M.; Hopf, Martin; Arndt, Markus

    2015-01-01

    Experimental research has become complex and thus a challenge to science education. Only very few students can typically be trained on advanced scientific equipment. It is therefore important to find new tools that allow all students to acquire laboratory skills individually and independent of where they are located. In a design-based research process we have investigated the feasibility of using a virtual laboratory as a photo-realistic and scientifically valid representation of advanced scientific infrastructure to teach modern experimental science, here, molecular quantum optics. We found a concept based on three educational principles that allows undergraduate students to become acquainted with procedures and concepts of a modern research field. We find a significant increase in student understanding using our Simulated Interactive Research Experiment (SiReX), by evaluating the learning outcomes with semi-structured interviews in a pre/post design. This suggests that this concept of an educational tool can be generalized to disseminate findings in other fields. PMID:26370627

  15. [Activities of Research Institute for Advanced Computer Science

    NASA Technical Reports Server (NTRS)

    Gross, Anthony R. (Technical Monitor); Leiner, Barry M.

    2001-01-01

    The Research Institute for Advanced Computer Science (RIACS) carries out basic research and technology development in computer science, in support of the National Aeronautics and Space Administrations missions. RIACS is located at the NASA Ames Research Center, Moffett Field, California. RIACS research focuses on the three cornerstones of IT research necessary to meet the future challenges of NASA missions: 1. Automated Reasoning for Autonomous Systems Techniques are being developed enabling spacecraft that will be self-guiding and self-correcting to the extent that they will require little or no human intervention. Such craft will be equipped to independently solve problems as they arise, and fulfill their missions with minimum direction from Earth. 2. Human-Centered Computing Many NASA missions require synergy between humans and computers, with sophisticated computational aids amplifying human cognitive and perceptual abilities. 3. High Performance Computing and Networking Advances in the performance of computing and networking continue to have major impact on a variety of NASA endeavors, ranging from modeling and simulation to analysis of large scientific datasets to collaborative engineering, planning and execution. In addition, RIACS collaborates with NASA scientists to apply IT research to a variety of NASA application domains. RIACS also engages in other activities, such as workshops, seminars, visiting scientist programs and student summer programs, designed to encourage and facilitate collaboration between the university and NASA IT research communities.

  16. TOPICAL REVIEW: Advances and challenges in computational plasma science

    NASA Astrophysics Data System (ADS)

    Tang, W. M.; Chan, V. S.

    2005-02-01

    Scientific simulation, which provides a natural bridge between theory and experiment, is an essential tool for understanding complex plasma behaviour. Recent advances in simulations of magnetically confined plasmas are reviewed in this paper, with illustrative examples, chosen from associated research areas such as microturbulence, magnetohydrodynamics and other topics. Progress has been stimulated, in particular, by the exponential growth of computer speed along with significant improvements in computer technology. The advances in both particle and fluid simulations of fine-scale turbulence and large-scale dynamics have produced increasingly good agreement between experimental observations and computational modelling. This was enabled by two key factors: (a) innovative advances in analytic and computational methods for developing reduced descriptions of physics phenomena spanning widely disparate temporal and spatial scales and (b) access to powerful new computational resources. Excellent progress has been made in developing codes for which computer run-time and problem-size scale well with the number of processors on massively parallel processors (MPPs). Examples include the effective usage of the full power of multi-teraflop (multi-trillion floating point computations per second) MPPs to produce three-dimensional, general geometry, nonlinear particle simulations that have accelerated advances in understanding the nature of turbulence self-regulation by zonal flows. These calculations, which typically utilized billions of particles for thousands of time-steps, would not have been possible without access to powerful present generation MPP computers and the associated diagnostic and visualization capabilities. In looking towards the future, the current results from advanced simulations provide great encouragement for being able to include increasingly realistic dynamics to enable deeper physics insights into plasmas in both natural and laboratory environments. This

  17. America's Climate Choices: Advancing the Science of Climate Change (Invited)

    NASA Astrophysics Data System (ADS)

    Matson, P. A.; Dietz, T.; Kraucunas, I.

    2010-12-01

    At the request of Congress, the National Academy of Sciences convened a series of coordinated activities to provide advice on actions and strategies the nation can take to respond to climate change. This suite of activities included a panel report on Advancing the Science of Climate Change. The report concludes that a strong, credible body of scientific evidence shows that climate change is occurring, is caused largely by human activities, and poses significant risks for a broad range of human and natural systems. As decision makers respond to these risks, the nation's scientific enterprise can contribute both by continuing to improve understanding of the causes and consequences of climate change, and by improving and expanding the options available to limit the magnitude of climate change and adapt to its impacts. To make this possible, the nation needs a comprehensive, integrated, and flexible climate change research enterprise that is closely linked with action-oriented programs at all levels. The report recommends that a single federal entity or program be given the authority and resources to coordinate a national research effort integrated across many disciplines and aimed at improving both understanding and responses to climate change. The U.S. Global Change Research Program, established in 1990, could fulfill this role, but it would need to address weaknesses in the current program and form partnerships with action-oriented programs at all levels. A comprehensive climate observing system, improved climate models and other analytical tools, investment in human capital, and better linkages between research and decision making are also essential for advancing the science of climate change.

  18. Advanced Instrumentation for Ultrafast Science at the LCLS

    SciTech Connect

    Berrah, Nora

    2015-10-13

    This grant supported a Single Investigator and Small Group Research (SISGR) application to enable multi-user research in Ultrafast Science using the Linac Coherent Light Source (LCLS), the world’s first hard x-ray free electron laser (FEL) which lased for the first time at 1.5 Å on April 20, 2009. The goal of our proposal was to enable a New Era of Science by requesting funds to purchase and build Advanced Instrumentation for Ultrafast Science (AIUS), to utilize the intense, short x-ray pulses produced by the LCLS. The proposed instrumentation will allow peer review selected users to probe the ultrasmall and capture the ultrafast. These tools will expand on the investment already made in the construction of the light source and its instrumentation in both the LCLS and LUSI projects. The AIUS will provide researchers in the AMO, Chemical, Biological and Condensed Matter communities with greater flexibility in defining their scientific agenda at the LCLS. The proposed instrumentation will complement and significantly augment the present AMO instrument (funded through the LCLS project) through detectors and capabilities not included in the initial suite of instrumentation at the facility. We have built all of the instrumentations and they have been utilized by scientists. Please see report attached.

  19. Mentoring Faculty: Results from National Science Foundation's ADVANCE Program

    NASA Astrophysics Data System (ADS)

    Holmes, M. A.

    2015-12-01

    Faculty mentoring programs are common components of National Science Foundation ADVANCE awards. The ADVANCE program aims to increase the number of women on the faculty in science, technology, engineering and mathematics (STEM) departments through grants to individuals and to entire institutions. These grants target a change in institutional culture so that faculty from non-majority groups will succeed and thrive. Mentoring programs are generally designed to fit the particular institution(s) or target population (e.g., meteorologists at the beginning of their careers). A successful mentoring program makes the implicit knowledge necessary for faculty success explicit: policies and practices are made transparent; routes for finding answers are clarified or generated with faculty input; faculty overcome a sense of isolation and develop a community. Mentoring programs may be formal, with assigned mentors and mentees, or informal, with opportunities for beginning, middle and advanced career STEM faculty to mingle, generally over food and sometimes with a formal speaker. The programs are formally evaluated; in general, attention to mentoring generates better outcomes for all faculty. Research indicates that most successful scientists have a network of mentors rather than relying on one person to help navigate department, institution, and profession. The University of Nebraska-Lincoln's (UNL) award, ADVANCE-Nebraska, offered opportunities for faculty to informally network over luncheons with women speakers, advanced in their careers. We also offered after-hours networking receptions. In response to faculty feedback, we shifted to a series of panel discussions entitled "Conversations". Most panels were conducted by successful UNL faculty; about one-third had an outside expert on a given topic. Topics were chosen based on faculty feedback and targeted specifically to beginning faculty (How to Start Up a Lab; How to Balance Teaching and Writing), mid-career faculty (Putting

  20. Advancing the 3Rs in regulatory ecotoxicology: A pragmatic cross-sector approach.

    PubMed

    Burden, Natalie; Benstead, Rachel; Clook, Mark; Doyle, Ian; Edwards, Peter; Maynard, Samuel K; Ryder, Kathryn; Sheahan, Dave; Whale, Graham; van Egmond, Roger; Wheeler, James R; Hutchinson, Thomas H

    2016-07-01

    The ecotoxicity testing of chemicals for prospective environmental safety assessment is an area in which a high number of vertebrates are used across a variety of industry sectors. Refining, reducing, and replacing the use of animals such as fish, birds, and amphibians for this purpose addresses the ethical concerns and the increasing legislative requirements to consider alternative test methods. Members of the UK-based National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) Ecotoxicology Working Group, consisting of representatives from academia, government organizations, and industry, have worked together over the past 6 y to provide evidence bases to support and advance the application of the 3Rs in regulatory ecotoxicity testing. The group recently held a workshop to identify the areas of testing, demands, and drivers that will have an impact on the future of animal use in regulatory ecotoxicology. As a result of these discussions, we have developed a pragmatic approach to prioritize and realistically address key opportunity areas, to enable progress toward the vision of a reduced reliance on the use of animals in this area of testing. This paper summarizes the findings of this exercise and proposes a pragmatic strategy toward our key long-term goals-the incorporation of reliable alternatives to whole-organism testing into regulations and guidance, and a culture shift toward reduced reliance on vertebrate toxicity testing in routine environmental safety assessment. Integr Environ Assess Manag 2016;12:417-421. © 2015 SETAC. PMID:26440537

  1. [Advances of poly (ionic liquid) materials in separation science].

    PubMed

    Liu, Cuicui; Guo, Ting; Su, Rina; Gu, Yuchen; Deng, Qiliang

    2015-11-01

    Ionic liquids, as novel ionization reagents, possess beneficial characteristics including good solubility, conductivity, thermal stability, biocompatibility, low volatility and non-flammability. Ionic liquids are attracting a mass of attention of analytical chemists. Poly (ionic liquid) materials have common performances of ionic liquids and polymers, and have been successfully applied in separation science area. In this paper, we discuss the interaction mechanisms between the poly(ionic liquid) materials and analytes including hydrophobic/hydrophilic interactions, hydrogen bond, ion exchange, π-π stacking and electrostatic interactions, and summarize the application advances of the poly(ionic liquid) materials in solid phase extraction, chromatographic separation and capillary electrophoresis. At last, we describe the future prospect of poly(ionic liquid) materials. PMID:26939357

  2. Advances in U.S. Heavy Ion Fusion Science

    SciTech Connect

    Logan, B.G.; Barnard, J.J.; Bieniosek, F.M.; Cohen, R.H.; Coleman, J.E.; Davidson, R.C.; Efthimion, P.C.; Friedman, A.; Gilson, E.P.; Grisham, L.R.; Grote, D.P.; Henestroza, E.; Kaganovich, I.D.; Kireeff-Covo, M.; Lee, E.P.; Leitner, M.A.; Lund, S.M.; Molvik, A.W.; Ni, P.; Perkins, L. J.; Qin, H.; Roy, P.K.; Sefkow, A.B.; Seidl, P.A.; Startsev, E.A.; Waldron, W.L.

    2007-09-01

    During the past two years, the US heavy ion fusion science program has made significant experimental and theoretical progress in simultaneous transverse and longitudinal beam compression, ion-beam-driven warm dense matter targets, high-brightness beam transport, advanced theory and numerical simulations, and heavy ion target physics for fusion. First experiments combining radial and longitudinal compression {pi} of intense ion beams propagating through background plasma resulted in on-axis beam densities increased by 700X at the focal plane. With further improvements planned in 2008, these results enable initial ion beam target experiments in warm dense matter to begin next year. They are assessing how these new techniques apply to higher-gain direct-drive targets for inertial fusion energy.

  3. Advances in U.S. Heavy Ion Fusion Science

    SciTech Connect

    Barnard, JJ; Logan, B.G.; Barnard, J.J.; Bieniosek, F.M.; Cohen, R.H.; Coleman, J.E.; Davidson, R.C.; Efthimion, P.C.; Friedman, A.; Gilson, E.P.; Grisham, L.R.; Grote, D.P.; Henestroza, E.; Kaganovich, I.D.; Kireeff-Covo, M.; Lee, E.P.; Leitner, M.A.; Lund, S.M.; Molvik, A.W.; Ni, P.; Perkins, L.J.; Qin, H.; Roy, P.K.; Sefkow, A.B.; Seidl, P.A.; Startsev, E.A.; Waldron, W.L.

    2007-09-03

    During the past two years, the US heavy ion fusion science program has made significant experimental and theoretical progress in simultaneous transverse and longitudinal beam compression, ion-beam-driven warm dense matter targets, high-brightness beam transport, advanced theory and numerical simulations, and heavy ion target physics for fusion. First experiments combining radial and longitudinal compression {pi} of intense ion beams propagating through background plasma resulted in on-axis beam densities increased by 700X at the focal plane. With further improvements planned in 2008, these results enable initial ion beam target experiments in warm dense matter to begin next year. They are assessing how these new techniques apply to higher-gain direct-drive targets for inertial fusion energy.

  4. Nuclear Forensic Science: Analysis of Nuclear Material Out of Regulatory Control

    NASA Astrophysics Data System (ADS)

    Kristo, Michael J.; Gaffney, Amy M.; Marks, Naomi; Knight, Kim; Cassata, William S.; Hutcheon, Ian D.

    2016-06-01

    Nuclear forensic science seeks to identify the origin of nuclear materials found outside regulatory control. It is increasingly recognized as an integral part of a robust nuclear security program. This review highlights areas of active, evolving research in nuclear forensics, with a focus on analytical techniques commonly employed in Earth and planetary sciences. Applications of nuclear forensics to uranium ore concentrates (UOCs) are discussed first. UOCs have become an attractive target for nuclear forensic researchers because of the richness in impurities compared to materials produced later in the fuel cycle. The development of chronometric methods for age dating nuclear materials is then discussed, with an emphasis on improvements in accuracy that have been gained from measurements of multiple radioisotopic systems. Finally, papers that report on casework are reviewed, to provide a window into current scientific practice.

  5. Marketing Regulatory Oversight of Advanced Therapy Medicinal Products (ATMPs) in Europe: The EMA/CAT Perspective.

    PubMed

    Salmikangas, Paula; Schuessler-Lenz, Martina; Ruiz, Sol; Celis, Patrick; Reischl, Ilona; Menezes-Ferreira, Margarida; Flory, Egbert; Renner, Matthias; Ferry, Nicolas

    2015-01-01

    With the release of Regulation 1394/2007, a new framework for gene and cell therapy medicinal products and tissue-engineered products was established in the European Union. For all three product classes, called advanced therapy medicinal products, a centralised marketing authorisation became mandatory. The European Medicines Agency (EMA) together with its Committee for Advanced Therapies, Committee for Human Medicinal Products and the network of national agencies is responsible for scientific evaluation of the marketing authorisation applications. For a new application, data and information relating to manufacturing processes and quality control of the active substance and the final product have to be submitted for evaluation together with data from non-clinical and clinical safety and efficacy studies. Technical requirements for ATMPs are defined in the legislation, and guidance for different products is available through several EMA/CAT guidelines. Due to the diversity of ATMPs, a tailored approach for regulating these products is considered necessary. Thus, a risk-based approach has been introduced for ATMPs allowing flexibility for the regulatory requirements. Since the regulatory framework for ATMPs was established, five products have been licenced in the European Union. However, the pipeline of new ATMPs is much bigger, as seen from the significant numbers of different products discussed by the CAT in scientific advice and classification procedures. In 2013, a public consultation on the ATMP Regulation was conducted by the European Commission, and the results were published in 2014. The report proposes several improvements for the current framework and established procedures for the regulation of ATMPs. PMID:26374215

  6. U.S. Science Agencies and GEWEX: Working Together to Advance Climate Science

    NASA Astrophysics Data System (ADS)

    Lawford, R. G.; Sorooshian, S.

    2007-12-01

    There have been major developments in climate science during the past two decades, mainly as a result of expanding capabilities to observe and model the climate system. Through its research on the global energy and water cycle, the Global Energy and Water cycle EXperiment (GEWEX) - one of the core projects of the World Climate Research Programme (WCRP) - has been making significant contributions to these developments. Support from the United States through the National Aeronautics and Space Administration (NASA), the National Oceanic and Atmospheric Administration (NOAA), the Department of Energy (DOE) and the Climate Change Science Program (CCSP) water cycle activities have contributed substantially to the effectiveness and success of GEWEX. In return, GEWEX has advanced the use of satellite data for climate applications, contributed to the development of meteorological and hydrologic services and has facilitated the emergence of a number of new insights that have advanced climate science. This presentation provides an overview of the above contributions and outlines GEWEX plans to continue such research until 2012 and possibly beyond. In particular, the contributions of NASA to hydrological science and climate studies will be described in the presentation, as well as the role of NOAA in supporting research related to monsoons, climate modeling and land surface studies. The support of DOE in GEWEX cloud process studies will also be introduced. The contributions of the U.S. through the Hydrology Applications Project (HAP) to the United Nations Educational, Scientific, and Cultural Organization (UNESCO) will also be outlined, including efforts to develop strategies for the application of GEWEX science to water resources through UNESCO International Hydrology Programme (IHP) networks. As this presentation will demonstrate, GEWEX continues to play a central role in addressing many of the water cycle issues being studied by the U.S. CCSP.

  7. Cancer Pharmacogenomics: Integrating Discoveries in Basic, Clinical and Population Sciences to Advance Predictive Cancer Care

    Cancer.gov

    Cancer Pharmacogenomics: Integrating Discoveries in Basic, Clinical and Population Sciences to Advance Predictive Cancer Care, a 2010 workshop sponsored by the Epidemiology and Genomics Research Program.

  8. Lincoln Advanced Science and Engineering Reinforcement (LASER) program

    NASA Astrophysics Data System (ADS)

    Williams, Willie E.

    Lincoln University, under the Lincoln Advanced Science and Engineering Reinforcement (LASER) Program, has identified and successfully recruited over 100 students for majors in technical fields. To date, over 70 percent of these students have completed or will complete technical degrees in engineering, physics, chemistry, and computer science. Of those completing the undergraduate degree, over 40 percent have gone on to graduate and professional schools. This success is attributable to well planned approaches to student recruitment, training, personal motivation, retention, and program staff. Very closely coupled to the above factors is a focus designed to achieve excellence in program services and student performance. Future contributions by the LASER Program to the pool of technical minority graduates will have a significant impact. This is already evident from the success of the students that began the first year of the program. With program plans to refine many of the already successful techniques, follow-on activities are expected to make even greater contributions to the availability of technically trained minorities. For example, undergraduate research exposure, broadened summer, and co-op work experiences will be enhanced.

  9. Advanced light microscopy core facilities: Balancing service, science and career.

    PubMed

    Ferrando-May, Elisa; Hartmann, Hella; Reymann, Jürgen; Ansari, Nariman; Utz, Nadine; Fried, Hans-Ulrich; Kukat, Christian; Peychl, Jan; Liebig, Christian; Terjung, Stefan; Laketa, Vibor; Sporbert, Anje; Weidtkamp-Peters, Stefanie; Schauss, Astrid; Zuschratter, Werner; Avilov, Sergiy

    2016-06-01

    Core Facilities (CF) for advanced light microscopy (ALM) have become indispensable support units for research in the life sciences. Their organizational structure and technical characteristics are quite diverse, although the tasks they pursue and the services they offer are similar. Therefore, throughout Europe, scientists from ALM-CFs are forming networks to promote interactions and discuss best practice models. Here, we present recommendations for ALM-CF operations elaborated by the workgroups of the German network of ALM-CFs, German Bio-Imaging (GerBI). We address technical aspects of CF planning and instrument maintainance, give advice on the organization and management of an ALM-CF, propose a scheme for the training of CF users, and provide an overview of current resources for image processing and analysis. Further, we elaborate on the new challenges and opportunities for professional development and careers created by CFs. While some information specifically refers to the German academic system, most of the content of this article is of general interest for CFs in the life sciences. Microsc. Res. Tech. 79:463-479, 2016. © 2016 THE AUTHORS MICROSCOPY RESEARCH AND TECHNIQUE PUBLISHED BY WILEY PERIODICALS, INC. PMID:27040755

  10. Lincoln Advanced Science and Engineering Reinforcement (LASER) program

    NASA Technical Reports Server (NTRS)

    Williams, Willie E.

    1989-01-01

    Lincoln University, under the Lincoln Advanced Science and Engineering Reinforcement (LASER) Program, has identified and successfully recruited over 100 students for majors in technical fields. To date, over 70 percent of these students have completed or will complete technical degrees in engineering, physics, chemistry, and computer science. Of those completing the undergraduate degree, over 40 percent have gone on to graduate and professional schools. This success is attributable to well planned approaches to student recruitment, training, personal motivation, retention, and program staff. Very closely coupled to the above factors is a focus designed to achieve excellence in program services and student performance. Future contributions by the LASER Program to the pool of technical minority graduates will have a significant impact. This is already evident from the success of the students that began the first year of the program. With program plans to refine many of the already successful techniques, follow-on activities are expected to make even greater contributions to the availability of technically trained minorities. For example, undergraduate research exposure, broadened summer, and co-op work experiences will be enhanced.

  11. Adapting Advances in Remediation Science to Long-Term Surveillance

    SciTech Connect

    Peterson, Dave

    2006-03-01

    Several facets of groundwater remediation stand to gain from the advances made during recent years in disciplines that contribute to remediation science. Engineered remedies designed to aggressively remove subsurface contamination should benefit from this progress, and more passive cleanup methods and the long-term monitoring of such passive approaches may benefit equally well if not more. The U.S. Department of Energy Office of Legacy Management (LM) has adopted a strategic plan that is designed to take advantage of technological improvements in the monitoring and assessment of both active and passive groundwater remedies. Flexible adaptation of new technologies, as they become available, to long-term surveillance at LM sites is expected to reduce site stewardship costs while ensuring the future protection of human health and the environment. Some of the technologies are expected to come from government initiatives that focus on the needs of subsurface monitoring. Additional progress in monitoring science will likely result from continual improvements in our understanding of contaminant fate-and-transport processes in the groundwater and the vadose zone.

  12. Pediatric Cardiopulmonary Resuscitation: Advances in Science, Techniques, and Outcomes

    PubMed Central

    Topjian, Alexis A.; Berg, Robert A.; Nadkarni, Vinay M.

    2009-01-01

    More than 25% of children survive to hospital discharge after in-hospital cardiac arrests, and 5% to 10% survive after out-of-hospital cardiac arrests. This review of pediatric cardiopulmonary resuscitation addresses the epidemiology of pediatric cardiac arrests, mechanisms of coronary blood flow during cardiopulmonary resuscitation, the 4 phases of cardiac arrest resuscitation, appropriate interventions during each phase, special resuscitation circumstances, extracorporeal membrane oxygenation cardiopulmonary resuscitation, and quality of cardiopulmonary resuscitation. The key elements of pathophysiology that impact and match the timing, intensity, duration, and variability of the hypoxic-ischemic insult to evidence-based interventions are reviewed. Exciting discoveries in basic and applied-science laboratories are now relevant for specific subpopulations of pediatric cardiac arrest victims and circumstances (eg, ventricular fibrillation, neonates, congenital heart disease, extracorporeal cardiopulmonary resuscitation). Improving the quality of interventions is increasingly recognized as a key factor for improving outcomes. Evolving training strategies include simulation training, just-in-time and just-in-place training, and crisis-team training. The difficult issue of when to discontinue resuscitative efforts is addressed. Outcomes from pediatric cardiac arrests are improving. Advances in resuscitation science and state-of-the-art implementation techniques provide the opportunity for further improvement in outcomes among children after cardiac arrest. PMID:18977991

  13. Workshop Advances Interdisciplinary Polar Science and Fast Ice Sheet Drilling

    NASA Astrophysics Data System (ADS)

    Tulaczyk, Slawek; Clow, Gary D.; Elliott, David H.; Powell, Ross D.; Priscu, John C.

    Over the last 50 years, the polar ice sheets covering Antarctica and Greenland have become natural scientific laboratories. Thanks to their unique environments, they yield discoveries that advance different geophysical disciplines and capture the imagination of the general public. The scientific community interested in sampling polar ice sheets and their substrata has been growing recently, and now incorporates biologists, geologists, geophysicists, glaciologists,and paleo-climatologists. This multidisciplinary interest is opening new research frontiers. Significantly advancing our scientific understanding along many of these frontiers will require targeted sampling strategies and the acquisition of data from arrays of deep access holes on spatial scales ranging from local to continent-wide. With this challenge in mind, more than 50 polar researchers and drilling engineers convened at a workshop to discuss scientific opportunities and technological challenges of fast-access ice sheet drilling. The overarching goal of the workshop was to begin the process of matching specific drilling and sampling technologies to broad objectives of interdisciplinary polar sciences. For convenience, the planned technological platform has been dubbed FASTDRILL. All scientific disciplines represented at the workshop identified several top-level questions that can be addressed with aid of the FASTDRILL platform. Biologists are interested in investigating life in icy environments as a potential analog for extraterrestrial life, and to better understand the origin and evolution of life on our planet. Interactions between tectonic processes and ice-sheet evolution are of primary importance to geologists and geophysicists.

  14. Scientific foundation of regulating ionizing radiation: application of metrics for evaluation of regulatory science information.

    PubMed

    Moghissi, A Alan; Gerraa, Vikrham Kumar; McBride, Dennis K; Swetnam, Michael

    2014-11-01

    This paper starts by describing the historical evolution of assessment of biologic effects of ionizing radiation leading to the linear non-threshold (LNT) system currently used to regulate exposure to ionizing radiation. The paper describes briefly the concept of Best Available Science (BAS) and Metrics for Evaluation of Scientific Claims (MESC) derived for BAS. It identifies three phases of regulatory science consisting of the initial phase, when the regulators had to develop regulations without having the needed scientific information; the exploratory phase, when relevant tools were developed; and the standard operating phase, when the tools were applied to regulations. Subsequently, an attempt is made to apply the BAS/MESC system to various stages of LNT. This paper then compares the exposure limits imposed by regulatory agencies and also compares them with naturally occurring radiation at several cities. Controversies about LNT are addressed, including judgments of the U.S. National Academies and their French counterpart. The paper concludes that, based on the BAS/MESC system, there is no disagreement between the two academies on the scientific foundation of LNT; instead, the disagreement is based on their judgment or speculation. PMID:25271928

  15. EDITORIAL: Focus on Advances in Surface and Interface Science 2008 FOCUS ON ADVANCES IN SURFACE AND INTERFACE SCIENCE 2008

    NASA Astrophysics Data System (ADS)

    Scheffler, Matthias; Schneider, Wolf-Dieter

    2008-12-01

    Basic research in surface and interface science is highly interdisciplinary, covering the fields of physics, chemistry, biophysics, geo-, atmospheric and environmental sciences, material science, chemical engineering, and more. The various phenomena are interesting by themselves, and they are most important in nearly all modern technologies, as for example electronic, magnetic, and optical devices, sensors, catalysts, lubricants, hard and thermal-barrier coatings, protection against corrosion and crack formation under harsh environments. In fact, detailed understanding of the elementary processes at surfaces is necessary to support and to advance the high technology that very much founds the prosperity and lifestyle of our society. Current state-of-the-art experimental studies of elementary processes at surfaces, of surface properties and functions employ a variety of sophisticated tools. Some are capable of revealing the location and motion of individual atoms. Others measure excitations (electronic, magnetic and vibronic), employing, for example, special light sources such as synchrotrons, high magnetic fields, or free electron lasers. The surprising variety of intriguing physical phenomena at surfaces, interfaces, and nanostructures also pose a persistent challenge for the development of theoretical descriptions, methods, and even basic physical concepts. This second focus issue on the topic of 'Advances in Surface and Interface Science' in New Journal of Physics, following on from last year's successful collection, provides an exciting synoptic view on the latest pertinent developments in the field. Focus on Advances in Surface and Interface Science 2008 Contents Organic layers at metal/electrolyte interfaces: molecular structure and reactivity of viologen monolayers Stephan Breuer, Duc T Pham, Sascha Huemann, Knud Gentz, Caroline Zoerlein, Ralf Hunger, Klaus Wandelt and Peter Broekmann Spin polarized d surface resonance state of fcc Co/Cu(001) K Miyamoto, K

  16. The effect of nature of science metacognitive prompts on science students' content and nature of science knowledge, metacognition, and self-regulatory efficacy

    NASA Astrophysics Data System (ADS)

    Peters, Erin E.

    The purpose of the present quasi-experimental mixed-method design is to examine the effectiveness of a developmental intervention (4-phase EMPNOS) to teach the nature of science using metacognitive prompts embedded in an inquiry unit. Eighty-eight (N=88) eighth grade students from four classrooms were randomly assigned to an experimental and a control group. All participants were asked to respond to a number of tests (content and nature of science knowledge) and surveys (metacognition of the nature of science, metacognitive orientation of the classroom, and self-regulatory efficacy). Participants were also interviewed to find problem solving techniques and shared experiences between the groups. It was hypothesized that the experimental group would outperform the control group in all measures. Partial support for the hypotheses was found. Specifically, results showed significant gains in content knowledge and nature of science knowledge of the experimental group over the control group. Qualitative findings revealed that students in the control group reported valuing authority over evidence, while the experimental group reported that they depended on consensus of their group on the interpretation of the evidence rather than authority, which is more closely aligned to the aspects of the nature of science. Four-phase EMPNOS may have implications as a useful classroom tool in guiding students to check their thinking for alignment to scientific thinking.

  17. Engaging High School Students in Advanced Math and Science Courses for Success in College: Is Advanced Placement the Answer?

    ERIC Educational Resources Information Center

    Kelley-Kemple, Thomas; Proger, Amy; Roderick, Melissa

    2011-01-01

    The current study provides an in-depth look at Advanced Placement (AP) math and science course-taking in one school district, the Chicago Public Schools (CPS). Using quasi-experimental methods, this study examines the college outcomes of students who take AP math and science courses. Specifically, this study asks whether students who take AP math…

  18. The Effect of the Advanced Placement Training and Incentive Program on Increasing Enrollment and Performance on Advanced Placement Science Exams

    ERIC Educational Resources Information Center

    Ramsey, Susan Brady

    2012-01-01

    The purpose of this study is to examine the effectiveness of the National Math and Science Initiative's Advanced Placement Training and Incentive Program (APTIP) on the number of students taking AP science courses and their performance. The study evaluated 39 schools over a six-year period in six states that participate in the APTIP. The…

  19. TerraFERMA: Harnessing Advanced Computational Libraries in Earth Science

    NASA Astrophysics Data System (ADS)

    Wilson, C. R.; Spiegelman, M.; van Keken, P.

    2012-12-01

    Many important problems in Earth sciences can be described by non-linear coupled systems of partial differential equations. These "multi-physics" problems include thermo-chemical convection in Earth and planetary interiors, interactions of fluids and magmas with the Earth's mantle and crust and coupled flow of water and ice. These problems are of interest to a large community of researchers but are complicated to model and understand. Much of this complexity stems from the nature of multi-physics where small changes in the coupling between variables or constitutive relations can lead to radical changes in behavior, which in turn affect critical computational choices such as discretizations, solvers and preconditioners. To make progress in understanding such coupled systems requires a computational framework where multi-physics problems can be described at a high-level while maintaining the flexibility to easily modify the solution algorithm. Fortunately, recent advances in computational science provide a basis for implementing such a framework. Here we present the Transparent Finite Element Rapid Model Assembler (TerraFERMA), which leverages several advanced open-source libraries for core functionality. FEniCS (fenicsproject.org) provides a high level language for describing the weak forms of coupled systems of equations, and an automatic code generator that produces finite element assembly code. PETSc (www.mcs.anl.gov/petsc) provides a wide range of scalable linear and non-linear solvers that can be composed into effective multi-physics preconditioners. SPuD (amcg.ese.ic.ac.uk/Spud) is an application neutral options system that provides both human and machine-readable interfaces based on a single xml schema. Our software integrates these libraries and provides the user with a framework for exploring multi-physics problems. A single options file fully describes the problem, including all equations, coefficients and solver options. Custom compiled applications are

  20. The Advanced Technology Solar Telescope: Science Drivers and Construction Status

    NASA Astrophysics Data System (ADS)

    Rimmele, Thomas; Berger, Thomas; McMullin, Joseph; Keil, Stephen; Goode, Phil; Knoelker, Michael; Kuhn, Jeff; Rosner, Robert; Casini, Roberto; Lin, Haosheng; Woeger, Friedrich; von der Luehe, Oskar; Tritschler, Alexandra; Atst Team

    2013-04-01

    The 4-meter Advance Technology Solar Telescope (ATST) currently under construction on the 3000 meter peak of Haleakala on Maui, Hawaii will be the world's most powerful solar telescope and the leading ground-based resource for studying solar magnetism. The solar atmosphere is permeated by a 'magnetic carpet' that constantly reweaves itself to control solar irradiance and its effects on Earth's climate, the solar wind, and space weather phenomena such as flares and coronal mass ejections. Precise measurement of solar magnetic fields requires a large-aperture solar telescope capable of resolving a few tens of kilometers on the solar surface. With its 4 meter aperture, the ATST will for the first time resolve magnetic structure at the intrinsic scales of plasma convection and turbulence. The ATST's ability to perform accurate and precise spectroscopic and polarimetric measurements of magnetic fields in all layers of the solar atmosphere, including accurate mapping of the elusive coronal magnetic fields, will be transformative in advancing our understanding of the magnetic solar atmosphere. The ATST will utilize the Sun as an important astro- and plasma-physics "laboratory" demonstrating key aspects of omnipresent cosmic magnetic fields. The ATST construction effort is led by the US National Solar Observatory. State-of-the-art instrumentation will be constructed by US and international partner institutions. The technical challenges the ATST is facing are numerous and include the design of the off-axis main telescope, the development of a high order adaptive optics system that delivers a corrected beam to the instrument laboratory, effective handling of the solar heat load on optical and structural elements, and minimizing scattered light to enable observations of the faint corona. The ATST project has transitioned from design and development to its construction phase. The project has awarded design and fabrication contracts for major telescope subsystems. Site

  1. Institutional Advancement and Public Engagement in the STEM and Health Science Disciplines

    ERIC Educational Resources Information Center

    Bloomfield, Victor A.; Kuhl, Michelle Wittcoff

    2007-01-01

    In today's resource-scarce environment, science, technology, engineering, and mathematics (STEM) and health science disciplines must partner with institutional advancement offices to support two key components of research universities--research and graduate education. Framing the partnership in terms of societal needs helps advancement officers to…

  2. Learnings and Recommendations to Advance 4-H Science Readiness

    ERIC Educational Resources Information Center

    Schmitt-McQuitty, Lynn; Carlos, Ramona; Smith, Martin H.

    2014-01-01

    The case study investigation reported here assessed California 4-H professionals' understanding of the essential components of effective 4-H Science programming as established by the National 4-H Science Mission Mandate. Using the 4-H Science Checklist as the basis for defining 4-H Science Readiness, academic and program staff were surveyed…

  3. Nutrigenomics: Definitions and Advances of This New Science

    PubMed Central

    Sales, N. M. R.; Pelegrini, P. B.; Goersch, M. C.

    2014-01-01

    The search for knowledge regarding healthy/adequate food has increased in the last decades among the world population, researchers, nutritionists, and health professionals. Since ancient times, humans have known that environment and food can interfere with an individual's health condition, and have used food and plants as medicines. With the advance of science, especially after the conclusion of the Human Genome Project (HGP), scientists started questioning if the interaction between genes and food bioactive compounds could positively or negatively influence an individual's health. In order to assess this interaction between genes and nutrients, the term “Nutrigenomics” was created. Hence, Nutrigenomics corresponds to the use of biochemistry, physiology, nutrition, genomics, proteomics, metabolomics, transcriptomics, and epigenomics to seek and explain the existing reciprocal interactions between genes and nutrients at a molecular level. The discovery of these interactions (gene-nutrient) will aid the prescription of customized diets according to each individual's genotype. Thus, it will be possible to mitigate the symptoms of existing diseases or to prevent future illnesses, especially in the area of Nontransmissible Chronic Diseases (NTCDs), which are currently considered an important world public health problem. PMID:24795820

  4. An Advanced Tokamak Fusion Nuclear Science Facility (FNSF-AT)

    NASA Astrophysics Data System (ADS)

    Chan, V. S.; Garofalo, A. M.; Stambaugh, R. D.

    2010-11-01

    A Fusion Development Facility (FDF) is a candidate for FNSF-AT. It is a compact steady-state machine of moderate gain that uses AT physics to provide the neutron fluence required for fusion nuclear science development. FDF is conceived as a double-null plasma with high elongation and triangularity, predicted to allow good confinement of high plasma pressure. Steady-state is achieved with high bootstrap current and radio frequency current drive. Neutral beam injection and 3D non-resonant magnetic field can provide edge plasma rotation for stabilization of MHD and access to Quiescent H-mode. The estimated power exhaust is somewhat lower than that of ITER because of higher core radiation and stronger tilting of the divertor plates. FDF is capable of further developing all elements of AT physics, qualifying them for an advanced performance DEMO. The latest concept has accounted for realistic neutron shielding and divertor implementation. Self-consistent evolution of the transport profiles and equilibrium will quantify the stability and confinement required to meet the FNS mission.

  5. Advanced Biotelemetry Systems for Space Life Sciences: PH Telemetry

    NASA Technical Reports Server (NTRS)

    Hines, John W.; Somps, Chris; Ricks, Robert; Kim, Lynn; Connolly, John P. (Technical Monitor)

    1995-01-01

    The SENSORS 2000! (S2K!) program at NASA's Ames Research Center is currently developing a biotelemetry system for monitoring pH and temperature in unrestrained subjects. This activity is part of a broader scope effort to provide an Advanced Biotelemetry System (ABTS) for use in future space life sciences research. Many anticipated research endeavors will require biomedical and biochemical sensors and related instrumentation to make continuous inflight measurements in a variable-gravity environment. Since crew time is limited, automated data acquisition, data processing, data storage, and subject health monitoring are required. An automated biochemical and physiological data acquisition system based on non invasive or implantable biotelemetry technology will meet these requirements. The ABTS will ultimately acquire a variety of physiological measurands including temperature, biopotentials (e.g. ECG, EEG, EMG, EOG), blood pressure, flow and dimensions, as well as chemical and biological parameters including pH. Development activities are planned in evolutionary, leveraged steps. Near-term activities include 1) development of a dual channel pH/temperature telemetry system, and 2) development of a low bandwidth, 4-channel telemetry system, that measures temperature, heart rate, pressure, and pH. This abstract describes the pH/temperature telemeter.

  6. The 160th national meeting of the American Association for the Advancement of Science: Science and a changing world

    SciTech Connect

    Not Available

    1994-01-01

    This is the Conference program for the American Association for the Advancement of Science. The overall topic is Science and A Changing World'. Major session areas covered including the following: Evaluating the environment: Where do we Stand ; Could we/should be engineer the Earth's Climate; Pacific Marine Science at Century's close; Predicting, Mitigating, and recovering from disasters; global change update 1994; sustainability from the ground up; energy policy research in Africa; defense conversion and technology transfer; arms control and international security.

  7. Integration of a Communicating Science Module into an Advanced Chemistry Laboratory Course

    ERIC Educational Resources Information Center

    Renaud, Jessica; Squier, Christopher; Larsen, Sarah C.

    2006-01-01

    A communicating science module was introduced into an advanced undergraduate physical chemistry laboratory course. The module was integrated into the course such that students received formal instruction in communicating science interwoven with the chemistry laboratory curriculum. The content of the communicating science module included three…

  8. Physics Comes to Winnipeg: The 1909 Meeting of the British Association for the Advancement of Science

    ERIC Educational Resources Information Center

    Klassen, Stephen; Dietrich, Sarah

    2010-01-01

    History of science can be used to bring scientific concepts to school science in a way that humanizes the protagonists and provides an appropriate context. The authors have researched the 1909 meeting of the British Association for the Advancement of Science (BAAS) in Winnipeg, a significant event in the city's history that has remained largely…

  9. Advances in distinguishing natural from induced Foxp3(+) regulatory T cells.

    PubMed

    Lin, Xiaohong; Chen, Maogen; Liu, Ya; Guo, Zhiyong; He, Xiaoshun; Brand, David; Zheng, Song Guo

    2013-01-01

    For more than a decade now, the regulatory T (Treg) cell has widely been considered as a critical subpopulation of T cells which can suppress effector T cell responses as well as suppressing the activity of other immune cells, such as mast cell, dendritic cells, and B cells. Treg cells have been broadly characterized as comprising of two main populations: thymus-derived natural Treg (nTreg) cells, and peripherally generated induced Treg (iTreg) cells. Both subsets have similar phenotypic characteristics and comparable suppressive function against T cell-mediated immune response and diseases. However, both Foxp3 positive Treg subsets exhibit some specific differences such as different mRNA transcripts and protein expression, epigenetic modification, and stability. These subtle differences reinforce the notion that they represent unique and distinct subsets. Accurately distinguishing iTregs from nTregs will help to clarify the biological features and contributions of each Treg subsets in peripheral tolerance, autoimmunity and tumor immunity. One difficult problem is that it has not been possible to distinguish iTregs from nTregs using surface markers until two recent articles were published to address this possibility. This review will focus on very recent advances in using molecular markers to differentiate these Treg subsets. PMID:23329997

  10. Development of Regulatory Technical Requirements for the Advanced Integral Type Research Reactor

    SciTech Connect

    Jo, Jong Chull; Yune, Young Gill; Kim, Woong Sik; Kim, Hho Jung

    2004-07-01

    This paper presents the current status of the study on the development of regulatory technical requirements for the licensing review of an advanced integral type research reactor of which the license application is expected in a few years. According to the Atomic Energy Act of Korea, both research and education reactors are subject to the technical requirements for power reactors in the licensing review. But, some of the requirements may not be applicable or insufficient for the licensing reviews of reactors with unique design features. Thus it is necessary to identify which review topics or areas can not be addressed by the existing requirements and to develop the required ones newly or supplement appropriately. Through the study performed so far, it has been identified that the following requirements need to be developed newly for the licensing review of SMART-P: the use of proven technology, the interfacial facility, the non-safety systems, and the metallic fuels. The approach and basis for the development of each of the requirements are discussed. (authors)

  11. Advancing Geospatial Technologies in Science and Social Science: A Case Study in Collaborative Education

    NASA Astrophysics Data System (ADS)

    Williams, N. A.; Morris, J. N.; Simms, M. L.; Metoyer, S.

    2007-12-01

    The Advancing Geospatial Skills in Science and Social Sciences (AGSSS) program, funded by NSF, provides middle and high school teacher-partners with access to graduate student scientists for classroom collaboration and curriculum adaptation to incorporate and advance skills in spatial thinking. AGSSS Fellows aid in the delivery of geospatially-enhanced activities utilizing technology such as geographic information systems, remote sensing, and virtual globes. The partnership also provides advanced professional development for both participating teachers and fellows. The AGSSS program is mutually beneficial to all parties involved. This successful collaboration of scientists, teachers, and students results in greater understanding and enthusiasm for the use of spatial thinking strategies and geospatial technologies. In addition, the partnership produces measurable improvements in student efficacy and attitudes toward processes of spatial thinking. The teacher partner training and classroom resources provided by AGSSS will continue the integration of geospatial activities into the curriculum after the project concludes. Time and resources are the main costs in implementing this partnership. Graduate fellows invest considerable time and energy, outside of academic responsibilities, to develop materials for the classroom. Fellows are required to be available during K-12 school hours, which necessitates forethought in scheduling other graduate duties. However, the benefits far outweigh the costs. Graduate fellows gain experience in working in classrooms. In exchange, students gain exposure to working scientists and their research. This affords graduate fellows the opportunity to hone their communication skills, and specifically allows them to address the issue of translating technical information for a novice audience. Teacher-partners and students benefit by having scientific expertise readily available. In summation, these experiences result in changes in teacher

  12. ARCHES: Advancing Research & Capacity in Hydrologic Education and Science

    NASA Astrophysics Data System (ADS)

    Milewski, A.; Fryar, A. E.; Durham, M. C.; Schroeder, P.; Agouridis, C.; Hanley, C.; Rotz, R. R.

    2013-12-01

    Educating young scientists and building capacity on a global scale is pivotal towards better understanding and managing our water resources. Based on this premise the ARCHES (Advancing Research & Capacity in Hydrologic Education and Science) program has been established. This abstract provides an overview of the program, links to access information, and describes the activities and outcomes of student participants from the Middle East and North Africa. The ARCHES program (http://arches.wrrs.uga.edu) is an integrated hydrologic education approach using online courses, field programs, and various hands-on workshops. The program aims to enable young scientists to effectively perform the high level research that will ultimately improve quality of life, enhance science-based decision making, and facilitate collaboration. Three broad, interlinked sets of activities are incorporated into the ARCHES program: (A1) the development of technical expertise, (A2) the development of professional contacts and skills, and (A3) outreach and long-term sustainability. The development of technical expertise (A1) is implemented through three progressive instructional sections. Section 1: Students were guided through a series of online lectures and exercises (Moodle: http://wrrs.uga.edu/moodle) covering three main topics (Remote Sensing, GIS, and Hydrologic Modeling). Section 2: Students participated in a hands-on workshop hosted at the University of Georgia's Water Resources and Remote Sensing Laboratory (WRRSL). Using ENVI, ArcGIS, and ArcSWAT, students completed a series of lectures and real-world applications (e.g., Development of Hydrologic Models). Section 3: Students participated in field studies (e.g., measurements of infiltration, recharge, streamflow, and water-quality parameters) conducted by U.S. partners and international collaborators in the participating countries. The development of professional contacts and skills (A2) was achieved through the promotion of networking

  13. Effects of Self-Regulatory Interventions on the Self-Efficacy of Community College Non-Science Majors.

    ERIC Educational Resources Information Center

    Maurer, Matthew J.

    This study examines how self-regulatory interventions affected the biology self-efficacy of a sample of non-science majors enrolled in a Midwestern community college. Portfolio assignments and a survey instrument were used to measure the self-efficacy of college non-majors for performing biology-related tasks. Results show that the vast majority…

  14. The 159th national meeting of the American Association for the advancement of science

    SciTech Connect

    Not Available

    1993-01-01

    This volume is the program/abstracts for the 1993 national meeting of the American Association for the Advancement of Science. The meeting was held in Boston from 11-16 February 1993. Symposia dealt with works on the following topics; perspectives on human genetics; confronting AIDS; biology, cells bugs; medical research society; social psychology neuroscience; future chemistry, from carbon to silicon; measuring the matter energy of the universe; earth's ever-changing atmosphere; causing coping with environmental change; agricultural biotechnology, plant protection production; science corporate enterprise; examining reforming the economic system; science, ethics the law; communicating science to the public; information technology the changing face of science; mathematics, concepts computations; international cooperation human survival; science for everyone; science religion, examining both; anthropology, dynamics of human history; international science issues; improving formal science education; and science education reform in America. Separate abstracts have been prepared for articles from this volume.

  15. FOXP3+Helios+ Regulatory T Cells, Immune Activation, and Advancing Disease in HIV-Infected Children.

    PubMed

    Khaitan, Alka; Kravietz, Adam; Mwamzuka, Mussa; Marshed, Fatma; Ilmet, Tiina; Said, Swalehe; Ahmed, Aabid; Borkowsky, William; Unutmaz, Derya

    2016-08-15

    Regulatory T cells (Tregs) are functionally suppressive CD4 T cells, critical for establishing peripheral tolerance and controlling inflammatory responses. Previous reports of Tregs during chronic HIV disease have conflicting results with higher or lower levels compared with controls. Identifying true Tregs with suppressive activity proves challenging during HIV infection, as traditional Treg markers, CD25 and FOXP3, may transiently upregulate expression as a result of immune activation (IA). Helios is an Ikaros family transcription factor that marks natural Tregs with suppressive activity and does not upregulate expression after activation. Coexpression of FOXP3 and Helios has been suggested as a highly specific marker of "bona fide" Tregs. We evaluated Treg subsets by FOXP3 coexpressed with either CD25 or Helios and their association with HIV disease progression in perinatally infected HIV-positive children. Identifying Tregs by FOXP3 coexpression with Helios rather than CD25 revealed markedly higher Treg frequencies, particularly in HIV+ children. Regardless of antiretroviral therapy, HIV-infected children had a selective expansion of memory FOXP3+Helios+ Tregs. The rise in memory Tregs correlated with declining HIV clinical status, indicated by falling CD4 percentages and CD4:CD8 ratios and increasing HIV plasma viremia and IA. In addition, untreated HIV+ children exhibited an imbalance between the levels of Tregs and activated T cells. Finally, memory Tregs expressed IA markers CD38 and Ki67 and exhaustion marker, PD-1, that tightly correlated with a similar phenotype in memory CD4 T cells. Overall, HIV-infected children had significant disruptions of memory Tregs that associated with advancing HIV disease. PMID:27003495

  16. Still spending dollars, still searching for sense: advanced practice nursing in an era of regulatory and economic turmoil.

    PubMed

    Safriet, B J

    1998-01-01

    Regulatory and market forces are dramatically affecting the practice prospects for advanced practice nurses (APNs). Examples include the designation of APNs as primary care providers by for-profit capitated systems, the elimination of "geographic" practice boundaries by the advent of telepractice, and the revision of governmental reimbursement provisions for entire categories of APNs. Educational, political, and economic challenges necessitate an increased APN leadership role in national and state policy reform efforts. PMID:9874960

  17. Misunderstanding the ``Nature'' of Co-Management: A Geography of Regulatory Science and Indigenous Knowledges (IK)

    NASA Astrophysics Data System (ADS)

    Watson, Annette

    2013-11-01

    Governments, NGOs, and natural scientists have increased research and policy-making collaborations with Indigenous peoples for governing natural resources, including official co-management regimes. However, there is continuing dissatisfaction with such collaborations, and calls for better communication and mutual learning to create more “adaptive” co-management regimes. This, however, requires that both Western and Indigenous knowledge systems be equal participants in the “co-production” of regulatory data. In this article, I examine the power dynamics of one co-management regulatory regime, conducting a multi-sited ethnography of the practices of researching and managing one transnational migratory species, greater white-fronted geese ( Anser albifrons frontalis), who nest where Koyukon Athabascans in Alaska, USA, practice subsistence. Analyzing the ethnographic data through the literatures of critical geography, science studies and Indigenous Studies, I describe how the practice of researching for co-management can produce conflict. “Scaling” the data for the co-management regime can marginalize Indigenous understandings of human-environment relations. While Enlightenment-based practices in wildlife biology avoid “anthropomorphism,” Indigenous Studies describes identities that operate through non-modern, deeply imbricated human-nonhuman identities that do not separate “nature” and “society” in making knowledge. Thus, misunderstanding the “nature” of their collaborations causes biologists and managers to measure and research the system in ways that erase how subsistence-based Indigenous groups already “manage” wildlife: by living through their ethical commitments to their fellow beings. At the end of the article, I discuss how managers might learn from these ontological and epistemological differences to better “co-produce” data for co-management.

  18. Supporting Systemic Science Reform - Collaboration to Advance Teaching Technology and Science (CATTS) and the National Optical Astronomy Observatory (NOAO)

    NASA Astrophysics Data System (ADS)

    Moore, K. S.; Offerdahl, E. G.; Hall-Wallace, M.; Pompea, S. M.; Regens, N.

    2003-12-01

    Through the NSF-funded Collaboration to Advance Teaching Technology and Science (CATTS), graduate and undergraduate students in the sciences partner with elementary, middle, and high school teachers to support efforts in science education. One such partnership, sponsored by the National Optical Astronomy Observatory (NOAO), works to enhance the teaching of astronomy and optics-related topics. Graduate and undergraduate Fellows in the CATTS/NOAO program support the efforts of teachers through the classroom implementation of GEMS (Great Explorations in Math and Science) curriculum guides such as Invisible Universe, Living With a Star, Real Reasons for the Seasons, Color Analyzers, and More Than Magnifiers. These guides are inquiry-based, hands-on activities that closely align with the National Science Education Standards. Details of the guides as well as the organization and benefits of the partnership will be described here. The NOAO/CATTS collaboration represents a high leverage program using quality instructional materials as part of a professional development effort for teachers while providing valuable student experiences in science education. As such, it represents an effective educational model that may be duplicated at other research facilities with EPO missions. The University of Arizona's Collaboration to Advance Teaching Technology and Science (CATTS) program is sponsored under grant 9979670 from the National Science Foundation. NOAO is operated by the Association of Universities for Research in Astronomy (AURA), Inc. under cooperative agreement with the National Science Foundation.

  19. Advanced Process Technology: Combi Materials Science and Atmospheric Processing (Fact Sheet)

    SciTech Connect

    Not Available

    2011-06-01

    Capabilities fact sheet for the National Center for Photovoltaics: Process Technology and Advanced Concepts -- High-Throughput Combi Material Science and Atmospheric Processing that includes scope, core competencies and capabilities, and contact/web information.

  20. Adherence to Scientific Method while Advancing Exposure Science

    EPA Science Inventory

    Paul Lioy was simultaneously a staunch adherent to the scientific method and an innovator of new ways to conduct science, particularly related to human exposure. Current challenges to science and the application of the scientific method are presented as they relate the approaches...

  1. Sensor Web Technology Challenges and Advancements for the Earth Science Decadal Survey Era

    NASA Technical Reports Server (NTRS)

    Norton, Charles D.; Moe, Karen

    2011-01-01

    This paper examines the Earth science decadal survey era and the role ESTO developed sensor web technologies can contribute to the scientific observations. This includes hardware and software technology advances for in-situ and in-space measurements. Also discussed are emerging areas of importance such as the potential of small satellites for sensor web based observations as well as advances in data fusion critical to the science and societal benefits of future missions, and the challenges ahead.

  2. Regulatory-Science: Biphasic Cancer Models or the LNT—Not Just a Matter of Biology!

    PubMed Central

    Ricci, Paolo F.; Sammis, Ian R.

    2012-01-01

    There is no doubt that prudence and risk aversion must guide public decisions when the associated adverse outcomes are either serious or irreversible. With any carcinogen, the levels of risk and needed protection before and after an event occurs, are determined by dose-response models. Regulatory law should not crowd out the actual beneficial effects from low dose exposures—when demonstrable—that are inevitably lost when it adopts the linear non-threshold (LNT) as its causal model. Because regulating exposures requires planning and developing protective measures for future acute and chronic exposures, public management decisions should be based on minimizing costs and harmful exposures. We address the direct and indirect effects of causation when the danger consists of exposure to very low levels of carcinogens and toxicants. The societal consequences of a policy can be deleterious when that policy is based on a risk assumed by the LNT, in cases where low exposures are actually beneficial. Our work develops the science and the law of causal risk modeling: both are interwoven. We suggest how their relevant characteristics differ, but do not attempt to keep them separated; as we demonstrate, this union, however unsatisfactory, cannot be severed. PMID:22740778

  3. Future Regulatory Science through a Global Product Development Strategy to Overcome the Device Lag.

    PubMed

    Tsuchii, Isao

    2016-01-01

    Environment that created "medical device lag (MDL)" has changed dramatically, and currently that term is not heard often. This was mainly achieved through the leadership of three groups: government, which determined to overcome MDL and took steps to do so; medical societies, which exhibited accountability in trial participation; and MD companies, which underwent a change in mindset that allowed comprehensive tripartite cooperation to reach the current stage. In particular, the global product development strategy (GPDS) of companies in a changing social environment has taken a new-turn with international harmonization trends, like Global Harmonization Task Force and International Council for Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. As a result, this evolution has created opportunities for treatment with cutting-edge MDs in Japanese society. Simultaneously, it has had a major impact on the planning process of GPDS of companies. At the same time, the interest of global companies has shifted to emerging economies for future potential profit since Japan no longer faces MDL issue. This economic trend makes MDLs a greater problem for manufacturers. From the regulatory science viewpoint, this new environment has not made it easy to plan a global strategy that will be adaptable to local societies. Without taking hasty action, flexible thinking from the global point of view is necessary to enable the adjustment of local strategies to fit the situation on the ground so that the innovative Japanese medical technology can be exported to a broad range of societies. PMID:27040334

  4. USGS Science Data Catalog - Open Data Advances or Declines

    NASA Astrophysics Data System (ADS)

    Frame, M. T.; Hutchison, V.; Zolly, L.; Wheeler, B.; Latysh, N.; Devarakonda, R.; Palanisamy, G.; Shrestha, B.

    2014-12-01

    The recent Office of Science and Technology Policy (OSTP) White House Open Data Policies (2013) have required Federal agencies to establish formal catalogues of their science data holdings and make these data easily available on Web sites, portals, and applications. As an organization, the USGS has historically excelled at making its data holdings freely available on its various Web sites (i.e., National, Scientific Programs, or local Science Center). In response to these requirements, the USGS Core Science Analytics, Synthesis, and Libraries program, in collaboration with DOE's Oak Ridge National Laboratory (ORNL) Mercury Consortium (funded by NASA, USGS, and DOE), and a number of other USGS organizations, established the Science Data Catalog (http://data.usgs.gov) cyberinfrastructure, content management processes/tools, and supporting policies. The USGS Science Data Catalog led the charge at USGS to improve the robustness of existing/future metadata collections; streamline and develop sustainable publishing to external aggregators (i.e., data.gov); and provide leadership to the U.S. Department of Interior in emerging Open Data policies, techniques, and systems. The session will discuss the current successes, challenges, and movement toward meeting these Open Data policies for USGS scientific data holdings. A retrospective look at the last year of implementation of these efforts within USGS will occur to determine whether these Open Data Policies are improving data access or limiting data availability. To learn more about the USGS Science Data Catalog, visit us at http://data.usgs.gov/info/about.html

  5. EDITORIAL: Focus on Advances in Surface and Interface Science 2009 FOCUS ON ADVANCES IN SURFACE AND INTERFACE SCIENCE 2009

    NASA Astrophysics Data System (ADS)

    Aeschlimann, Martin; Schneider, Wolf-Dieter

    2009-12-01

    Nearly 80% of all chemical reactions in nature and in human technology take place at boundaries between phases, i.e., at surfaces or interfaces. A detailed understanding of the elementary processes at surfaces and interfaces is therefore necessary to support and to advance the high technology that very much founds the prosperity and life style of our society. One of the challenges of modern surface science is thus to expand its range of investigations to all types of surfaces and interfaces and to develop a thorough understanding of the relationships between molecular-scale surface properties and parameters relevant to potential applications and devices. Beyond these technological drivers, however, is a rich range of novel and fundamental physical and chemical properties at surfaces and interfaces down to the nanoscale whose study represents outstanding intellectual challenges. The current research focuses on atomic- and molecular-level studies of the structure (atomic and electronic), bonding, reactivity, dynamics, restructuring, and magnetism at the surfaces and interfaces of metals, oxides, semiconductors, polymers, biological molecules, and liquids. Such investigations are becoming more and more important in view of the increasing emphasis on nanometer-scale structures in almost every technological application, from heterogeneous catalysis to microcircuit fabrication to magnetic data storage. As the scale of devices continues to be reduced, the distinction between bulk and surface properties becomes blurred, and all of the properties of materials tend to become interfacial This Focus Issue includes exciting new developments in the field of surface and interface science ranging, e.g., from the properties of metal-water interfaces to single-atom contacts. Special emphasis was taken to coupling theory with experiments aimed at elucidating fundamental atomic scale phenomena. It combines a broad expert and frontiers survey of research in this field today with an up

  6. FDA Researchers Advance Science for Vaccines to Prevent Mumps and Whooping Cough

    MedlinePlus

    ... Home For Consumers Consumer Updates FDA Researchers Advance Science for Vaccines to Prevent Mumps and Whooping Cough ... that FDA studies will continue. “We enjoy the science,” says Merkel. “But what’s driving our research is ...

  7. A Strategic Action Plan for Advancing Math and Science Education in New Mexico 2007-2010

    ERIC Educational Resources Information Center

    New Mexico Public Education Department, 2007

    2007-01-01

    This Strategic Action Plan for Advancing Math and Science Education is an initial outline of strategies, actions, measures of progress, resources needed, timelines, and responsible parties. The Plan focuses on these three main goals: (1) increasing student interest, participation, and achievement in math and science; (2) raising public support and…

  8. Academic Integration Supplement to the Advanced Food Science and Nutrition Curriculum Guide.

    ERIC Educational Resources Information Center

    Texas Tech Univ., Lubbock. Home Economics Curriculum Center.

    This supplement to an advanced food science and nutrition curriculum guide was developed for use in integrating academic principles with vocational home economics education in Texas. It contains learning and evaluation experiences specifically designed to integrate mathematics, science, language arts, and social studies principles within the…

  9. Advancing Science Literacy Through the Climate Change National Forum

    NASA Astrophysics Data System (ADS)

    Nielsen-Gammon, J. W.; Quirke, M.; Lefer, B. L.; Hester, T.

    2014-12-01

    The Climate Change National Forum (http://climatechangenationalforum.org) was established almost a year ago to provide a publicly visible platform for discussion of scientific issues related to climate change and, at a later date, policy options motivated by climate change science. The site is also designed to promote public literacy in the culture and conduct of science by incorporating dozens of active scientists in a broad range of climate science and related fields and encouraging dialogue among those scientists. The forum provides a rare window into scientific debate, allowing non-scientists to see how scientists evaluate the work of others, construct meaning out of various bits of evidence, formulate ideas, challenge their colleagues, and (on occasion) develop a consensus. As such, the site is intended to have educational value well beyond its climate science focus.

  10. Innovations in Science and Mathematics Education: Advanced Designs for Technologies of Learning.

    ERIC Educational Resources Information Center

    Jacobson, Michael J., Ed.; Kozma, Robert B., Ed.

    This collection of essays consists of current work that addresses the challenge not just to put the newest technologies in schools, but to identify advanced ways to design and use these new technologies to advance learning. These essays are intended for science and mathematics educators, educational and cognitive researchers, instructional…

  11. The Influence of Applied STEM Coursetaking on Advanced Mathematics and Science Coursetaking

    ERIC Educational Resources Information Center

    Gottfried, Michael A.

    2015-01-01

    Advanced mathematics and science course taking is critical in building the foundation for students to advance through the STEM pathway-from high school to college to career. To invigorate students' persistence in STEM fields, high schools have been introducing applied STEM courses into the curriculum as a way to reinforce concepts learned in…

  12. Advanced Technologies and Data Management Practices in Environmental Science: Lessons from Academia

    ERIC Educational Resources Information Center

    Hernandez, Rebecca R.; Mayernik, Matthew S.; Murphy-Mariscal, Michelle L.; Allen, Michael F.

    2012-01-01

    Environmental scientists are increasing their capitalization on advancements in technology, computation, and data management. However, the extent of that capitalization is unknown. We analyzed the survey responses of 434 graduate students to evaluate the understanding and use of such advances in the environmental sciences. Two-thirds of the…

  13. A year of advancement and reflection in nephrology science.

    PubMed

    Cases, Aleix

    2006-03-01

    The 38th Annual Meeting of the American Society of Nephrology was held November 8-13, 2005, in Philadelphia, Pennsylvania, USA. The meeting offered the latest findings in basic and clinical nephrology science and was attended by more than 12,000 specialists from around the world. This year's sessions included 58 basic and clinical science symposia, 29 clinical nephrology conference sessions, 24 official symposia, 51 free communications and three poster sessions. Highlights of the meeting are discussed. PMID:16628267

  14. Science at the Speed of Light: Advanced Photon Source

    ScienceCinema

    Murray Gibson

    2010-01-08

    An introduction and overview of the Advanced Photon Source at Argonne National Laboratory, the technology that produces the brightest x-ray beams in the Western Hemisphere, and the research carried out by scientists using those x-rays.

  15. Science at the Speed of Light: Advanced Photon Source

    SciTech Connect

    Murray Gibson

    2009-06-03

    An introduction and overview of the Advanced Photon Source at Argonne National Laboratory, the technology that produces the brightest x-ray beams in the Western Hemisphere, and the research carried out by scientists using those x-rays.

  16. Advancing Symptom Science Through Use of Common Data Elements

    PubMed Central

    Redeker, Nancy S.; Anderson, Ruth; Bakken, Suzanne; Corwin, Elizabeth; Docherty, Sharron; Dorsey, Susan G.; Heitkemper, Margaret; McCloskey, Donna Jo; Moore, Shirley; Pullen, Carol; Rapkin, Bruce; Schiffman, Rachel; Waldrop-Valverde, Drenna; Grady, Patricia

    2015-01-01

    Background Use of common data elements (CDEs), conceptually defined as variables that are operationalized and measured in identical ways across studies, enables comparison of data across studies in ways that would otherwise be impossible. Although healthcare researchers are increasingly using CDEs, there has been little systematic use of CDEs for symptom science. CDEs are especially important in symptom science because people experience common symptoms across a broad range of health and developmental states, and symptom management interventions may have common outcomes across populations. Purposes The purposes of this article are to (a) recommend best practices for the use of CDEs for symptom science within and across centers; (b) evaluate the benefits and challenges associated with the use of CDEs for symptom science; (c) propose CDEs to be used in symptom science to serve as the basis for this emerging science; and (d) suggest implications and recommendations for future research and dissemination of CDEs for symptom science. Design The National Institute of Nursing Research (NINR)-supported P20 and P30 Center directors applied published best practices, expert advice, and the literature to identify CDEs to be used across the centers to measure pain, sleep, fatigue, and affective and cognitive symptoms. Findings We generated a minimum set of CDEs to measure symptoms. Conclusions The CDEs identified through this process will be used across the NINR Centers and will facilitate comparison of symptoms across studies. We expect that additional symptom CDEs will be added and the list will be refined in future work. Clinical Relevance Journal of Nursing Scholarship, 47:5, ©2015 Sigma Theta Tau International. PMID:26250061

  17. Advanced Bioinks for 3D Printing: A Materials Science Perspective.

    PubMed

    Chimene, David; Lennox, Kimberly K; Kaunas, Roland R; Gaharwar, Akhilesh K

    2016-06-01

    Advanced bioinks for 3D printing are rationally designed materials intended to improve the functionality of printed scaffolds outside the traditional paradigm of the "biofabrication window". While the biofabrication window paradigm necessitates compromise between suitability for fabrication and ability to accommodate encapsulated cells, recent developments in advanced bioinks have resulted in improved designs for a range of biofabrication platforms without this tradeoff. This has resulted in a new generation of bioinks with high print fidelity, shear-thinning characteristics, and crosslinked scaffolds with high mechanical strength, high cytocompatibility, and the ability to modulate cellular functions. In this review, we describe some of the promising strategies being pursued to achieve these goals, including multimaterial, interpenetrating network, nanocomposite, and supramolecular bioinks. We also provide an overview of current and emerging trends in advanced bioink synthesis and biofabrication, and evaluate the potential applications of these novel biomaterials to clinical use. PMID:27184494

  18. Mock data and science challenge for detecting an astrophysical stochastic gravitational-wave background with Advanced LIGO and Advanced Virgo

    NASA Astrophysics Data System (ADS)

    Meacher, Duncan; Coughlin, Michael; Morris, Sean; Regimbau, Tania; Christensen, Nelson; Kandhasamy, Shivaraj; Mandic, Vuk; Romano, Joseph D.; Thrane, Eric

    2015-09-01

    The purpose of this mock data and science challenge is to prepare the data analysis and science interpretation for the second generation of gravitational-wave experiments Advanced LIGO-Virgo in the search for a stochastic gravitational-wave background signal of astrophysical origin. Here we present a series of signal and data challenges, with increasing complexity, whose aim is to test the ability of current data analysis pipelines at detecting an astrophysically produced gravitational-wave background, test parameter estimation methods and interpret the results. We introduce the production of these mock data sets that includes a realistic observing scenario data set where we account for different sensitivities of the advanced detectors as they are continuously upgraded toward their design sensitivity. After analyzing these with the standard isotropic cross-correlation pipeline we find that we are able to recover the injected gravitational-wave background energy density to within 2 σ for all of the data sets and present the results from the parameter estimation. The results from this mock data and science challenge show that advanced LIGO and Virgo will be ready and able to make a detection of an astrophysical gravitational-wave background within a few years of operations of the advanced detectors, given a high enough rate of compact binary coalescing events.

  19. Advanced X-ray Astrophysics Facility (AXAF) science instruments

    NASA Technical Reports Server (NTRS)

    Winkler, Carl E.; Dailey, Carroll C.; Cumings, Nesbitt P.

    1991-01-01

    The overall AXAF program is summarized, with particular emphasis given to its science instruments. The science objectives established for AXAF are to determine the nature of celestial objects, from normal stars to quasars, to elucidate the nature of the physical processes which take place in and between astronomical objects, and to shed light on the history and evolution of the universe. Attention is given to the AXAF CCD imaging spectrometer, which is to provide spectrally and temporally resolved imaging, or, in conjunction with transmission grating, high-resolution dispersed spectral images of celestial sources. A high-resolution camera, an X-ray spectrometer, and the Bragg Crystal Spectrometer are also discussed.

  20. GNVQ science at advanced level: motivation and self-esteem

    NASA Astrophysics Data System (ADS)

    Solomon, J.

    1995-07-01

    An interview study carried out in the pilot year of the new GNVQ in science at A-level has shown that the use of grading criteria, which require independent learning, as a method of assessment is better for students' motivation and self-esteem.

  1. Advancing the art and science of dietary assessment through technology

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This research editorial presents the background against which dietitians may consider the benefits of new technology being incorporated into the art and science of dietary assessment. The background provides past changes that have increased the need for computer applications being developed for indi...

  2. Advancing Intervention Science through Effectiveness Research: A Global Perspective

    ERIC Educational Resources Information Center

    Ferrer-Wreder, Laura; Adamson, Lena; Kumpfer, Karol L.; Eichas, Kyle

    2012-01-01

    Background: Effectiveness research is maturing as a field within intervention and prevention science. Effectiveness research involves the implementation and evaluation of the effectiveness of the dissemination of evidence-based interventions in everyday circumstances (i.e., type 2 translational research). Effectiveness research is characterized by…

  3. Advanced Placement Computer Science with Pascal. Volume 2. Experimental Edition.

    ERIC Educational Resources Information Center

    New York City Board of Education, Brooklyn, NY.

    This curriculum guide presents 100 lessons for an advanced placement course on programming in Pascal. Some of the topics covered include arrays, sorting, strings, sets, records, computers in society, files, stacks, queues, linked lists, binary trees, searching, hashing, and chaining. Performance objectives, vocabulary, motivation, aim,…

  4. Reaching the Next Stephen Hawking: Five Ways to Help Students with Disabilities in Advanced Placement Science Classes

    ERIC Educational Resources Information Center

    Howard, Lori A.; Potts, Elizabeth A.; Linz, Ed

    2013-01-01

    As the federal government encourages all students to attempt advanced math and science courses, more students with disabilities are enrolling in Advanced Placement (AP) science classes. AP science teachers can better serve these students by understanding the various types of disabilities (whether physical, learning, emotional, or behavioral),…

  5. Advancing Climate Change and Impacts Science Through Climate Informatics

    NASA Astrophysics Data System (ADS)

    Lenhardt, W.; Pouchard, L. C.; King, A. W.; Branstetter, M. L.; Kao, S.; Wang, D.

    2010-12-01

    This poster will outline the work to date on developing a climate informatics capability at Oak Ridge National Laboratory (ORNL). The central proposition of this effort is that the application of informatics and information science to the domain of climate change science is an essential means to bridge the realm of high performance computing (HPC) and domain science. The goal is to facilitate knowledge capture and the creation of new scientific insights. For example, a climate informatics capability will help with the understanding and use of model results in domain sciences that were not originally in the scope. From there, HPC can also benefit from feedback as the new approaches may lead to better parameterization in the models. In this poster we will summarize the challenges associated with climate change science that can benefit from the systematic application of informatics and we will highlight our work to date in creating the climate informatics capability to address these types of challenges. We have identified three areas that are particularly challenging in the context of climate change science: 1) integrating model and observational data across different spatial and temporal scales, 2) model linkages, i.e. climate models linked to other models such as hydrologic models, and 3) model diagnostics. Each of these has a methodological component and an informatics component. Our project under way at ORNL seeks to develop new approaches and tools in the context of linking climate change and water issues. We are basing our work on the following four use cases: 1) Evaluation/test of CCSM4 biases in hydrology (precipitation, soil water, runoff, river discharge) over the Rio Grande Basin. User: climate modeler. 2) Investigation of projected changes in hydrology of Rio Grande Basin using the VIC (Variable Infiltration Capacity Macroscale) Hydrologic Model. User: watershed hydrologist/modeler. 3) Impact of climate change on agricultural productivity of the Rio Grande

  6. [Necessary changes for advancing nursing as caring science].

    PubMed

    de Pires, Denise Elvira Pires

    2013-09-01

    The article aimed to reflect upon the challenges involved in strengthening Nursing as a caring science. It is founded on the sociological theory, connecting three approaches: the historical-dialectic materialism perspective about the working process in health care and nursing; the sociology of professions from a critical perspective; and the philosophy of science. The discussion is organized considering the aspects of Nursing as a discipline, work and health care profession. It sustains that knowledge production should be driven both by the purpose of Nursing work which is providing care to human beings with health needs and to advocate for the indispensable work conditions to a safe and responsible practice. It concludes that to strengthening Nursing it is necessary to produce knowledge to support nursing care and the political actions defending safe work conditions, the universal right to health as well safe and high quality care. PMID:24092308

  7. How the Common Component Architecture Advances Compuational Science

    SciTech Connect

    Kumfert, G; Bernholdt, D; Epperly, T; Kohl, J; McInnes, L C; Parker, S; Ray, J

    2006-06-19

    Computational chemists are using Common Component Architecture (CCA) technology to increase the parallel scalability of their application ten-fold. Combustion researchers are publishing science faster because the CCA manages software complexity for them. Both the solver and meshing communities in SciDAC are converging on community interface standards as a direct response to the novel level of interoperability that CCA presents. Yet, there is much more to do before component technology becomes mainstream computational science. This paper highlights the impact that the CCA has made on scientific applications, conveys some lessons learned from five years of the SciDAC program, and previews where applications could go with the additional capabilities that the CCA has planned for SciDAC 2.

  8. 78 FR 77181 - Self-Regulatory Organizations; The Options Clearing Corporation; Advance Notice Concerning the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-20

    ... Governance Committee Charter December 16, 2013. Pursuant to Section 19(b)(1) of the Securities Exchange Act... Terms of Substance of the Advance Notice This advance notice concerns the charter of the Governance... the Governance Committee (``GC'') at its May 21, 2013, meeting and approved the GC Charter at...

  9. Advancing microbial sciences by individual-based modelling.

    PubMed

    Hellweger, Ferdi L; Clegg, Robert J; Clark, James R; Plugge, Caroline M; Kreft, Jan-Ulrich

    2016-07-01

    Remarkable technological advances have revealed ever more properties and behaviours of individual microorganisms, but the novel data generated by these techniques have not yet been fully exploited. In this Opinion article, we explain how individual-based models (IBMs) can be constructed based on the findings of such techniques and how they help to explore competitive and cooperative microbial interactions. Furthermore, we describe how IBMs have provided insights into self-organized spatial patterns from biofilms to the oceans of the world, phage-CRISPR dynamics and other emergent phenomena. Finally, we discuss how combining individual-based observations with IBMs can advance our understanding at both the individual and population levels, leading to the new approach of microbial individual-based ecology (μIBE). PMID:27265769

  10. Advancing Materials Science using Neutrons at Oak Ridge National Laboratory

    ScienceCinema

    Carpenter, John

    2014-06-03

    Jack Carpenter, pioneer of accelerator-based pulsed spallation neutron sources, talks about neutron science at Oak Ridge National Laboratory (ORNL) and a need for a second target station at the Spallation Neutron Source (SNS). ORNL is the Department of Energy's largest multiprogram science and energy laboratory, and is home to two scientific user facilities serving the neutron science research community: the High Flux Isotope Reactor (HFIR) and SNS. HFIR and SNS provide researchers with unmatched capabilities for understanding the structure and properties of materials, macromolecular and biological systems, and the fundamental physics of the neutron. Neutrons provide a window through which to view materials at a microscopic level that allow researchers to develop better materials and better products. Neutrons enable us to understand materials we use in everyday life. Carpenter explains the need for another station to produce long wavelength neutrons, or cold neutrons, to answer questions that are addressed only with cold neutrons. The second target station is optimized for that purpose. Modern technology depends more and more upon intimate atomic knowledge of materials, and neutrons are an ideal probe.

  11. Advancing Materials Science using Neutrons at Oak Ridge National Laboratory

    SciTech Connect

    Carpenter, John

    2014-04-24

    Jack Carpenter, pioneer of accelerator-based pulsed spallation neutron sources, talks about neutron science at Oak Ridge National Laboratory (ORNL) and a need for a second target station at the Spallation Neutron Source (SNS). ORNL is the Department of Energy's largest multiprogram science and energy laboratory, and is home to two scientific user facilities serving the neutron science research community: the High Flux Isotope Reactor (HFIR) and SNS. HFIR and SNS provide researchers with unmatched capabilities for understanding the structure and properties of materials, macromolecular and biological systems, and the fundamental physics of the neutron. Neutrons provide a window through which to view materials at a microscopic level that allow researchers to develop better materials and better products. Neutrons enable us to understand materials we use in everyday life. Carpenter explains the need for another station to produce long wavelength neutrons, or cold neutrons, to answer questions that are addressed only with cold neutrons. The second target station is optimized for that purpose. Modern technology depends more and more upon intimate atomic knowledge of materials, and neutrons are an ideal probe.

  12. Using implementation science to advance cancer prevention in India.

    PubMed

    Krishnan, Suneeta; Sivaram, Sudha; Anderson, Benjamin O; Basu, Partha; Belinson, Jerome L; Bhatla, Neerja; D'Cruz, Anil; Dhillon, Preet K; Gupta, Prakash C; Joshi, Niranjan; Jhulka, P K; Kailash, Uma; Kapambwe, Sharon; Katoch, Vishwa Mohan; Kaur, Prabhdeep; Kaur, Tanvir; Mathur, Prashant; Prakash, Anshu; Sankaranarayanan, R; Selvam, Jerard M; Seth, Tulika; Shah, Keerti V; Shastri, Surendra; Siddiqi, Maqsood; Srivastava, Anurag; Trimble, Edward; Rajaraman, Preetha; Mehrotra, Ravi

    2015-01-01

    Oral, cervical and breast cancers, which are either preventable and/or amenable to early detection and treatment, are the leading causes of cancer-related morbidity and mortality in India. In this paper, we describe implementation science research priorities to catalyze the prevention and control of these cancers in India. Research priorities were organized using a framework based on the implementation science literature and the World Health Organization's definition of health systems. They addressed both community-level as well as health systems-level issues. Community-level or "pull" priorities included the need to identify effective strategies to raise public awareness and understanding of cancer prevention, monitor knowledge levels, and address fear and stigma. Health systems-level or "push" and "infrastructure" priorities included dissemination of evidence- based practices, testing of point-of-care technologies for screening and diagnosis, identification of appropriate service delivery and financing models, and assessment of strategies to enhance the health workforce. Given the extent of available evidence, it is critical that cancer prevention and treatment efforts in India are accelerated. Implementation science research can generate critical insights and evidence to inform this acceleration. PMID:25987015

  13. Advancing Precollege Science and Mathematics Education in San Diego County

    NASA Astrophysics Data System (ADS)

    Schissel, D. P.; DIII--D Education Outreach Team

    1996-11-01

    The existing educational tour that was created by GA's Fusion Group has been enhanced this past year by an additional DIII--D tour station focusing on Radiation, Radioactivity, and Risk Assessment which includes ``hands-on'' demonstrations and environmental radiation risks. Additionally, with the assistance of local area science teachers, a new Electromagnetic Spectrum Curriculum was developed, field-tested, and assessed, with activities, demonstrations, and experiments to be used in science classes. Included were curriculum, workbook, and resource boxes supporting the curriculum with items not easily accessable to classrooms. A videotape ``Fusion, Nature's Fundamental Energy Source,'' was produced and incorporates animations giving an overview of fusion to be utilized as a tool for teachers in the classroom. A fusion poster was designed for high school classrooms to entice student inquiries, includes information about our fusion educational WWW site, and an e-mail address for science questions to the ``Wizard,'' which will be answered by scientists/ engineers from General Atomics' Fusion Group. These enhancements and planned projects will be presented.

  14. The ADVANCE Program: Targeting the Increase in the Participation and Advancement of Women in Academic Science and Engineering Careers

    NASA Astrophysics Data System (ADS)

    Esperanca, S.

    2003-12-01

    The goal of NSF's ADVANCE Program is to help increase the participation of women in the scientific and engineering workforce through the increased representation and advancement of women in academic science and engineering careers. The Program tries to address this under representation by focusing on support for men and women with three approaches: institutional (Institutional Transformation), grass-root (Leadership), and individual (Fellows) support. The ADVANCE Program alternates with a round of Institutional and Leadership awards in one year and a Fellows competition the next. Since its inception in 2001, NSF has had two competitive rounds for each of the three award types and will have spent approximately 75 M\\ by the end of the next fiscal year (2004). The first and second ADVANCE Institutional Transformation competitions (FY 2001 and 2003) received over 70 proposals each. These awards are for multi-year support in the amount of 3-4M\\ each. Details and access to the websites for the ADVANCE programs of each institution can be found in NSF's ADVANCE webpage at http://nsf.gov/home/crssprgm/advance/itwebsites.htm. The number of proposals submitted for the Leadership awards competition dropped from 35 in 2001 to 26 in 2003, despite an increase in the allowed award size for the second round. In terms of projected goals, this part of ADVANCE is perhaps the most eclectic. Some Leadership awards were made to professional societies to work specifically with their respective scientific communities in identifying needs that might be peculiar to a field of science. In the first round of the Leadership awards, PI Mary-Anne Holmes of the University of Nebraska-Lincoln and collaborators received a grant to work with the Association of Women Geoscientists to determine the current status of women geoscientists in the US. These grantees hope to disseminate the information gathered under this award broadly in order to educate women students and faculty on strategies to

  15. The Role of Science and Technology in the Advancement of Women Worldwide

    SciTech Connect

    Hays, I.; Farhar, B.

    2000-10-12

    Participants at the 1995 Fourth World Conference on Women, held in Beijing, China, created a Platform for Action focusing on 12 critical areas of concern (poverty, education and training, health, violence, armed conflict, economy, decision-making, institutional mechanisms, human rights, the media, environment, and the girl child) and the serious barriers to women's health and well-being in each area. Subsequently, the Department of Energy funded a study, described here, that shows, in a literature review and in interviews with 15 women experts, how science and technology can be integral to women's advancement in each of the 12 critical areas. Among the study's conclusions are that differing perspectives exist (pro-science, relativist, and skeptical) on the role of science and technology in women's lives and that these differing perspectives may explain why communication is difficult among policy makers and with scientists about the role science and technology may play in the advancem ent of women worldwide. Recommendations call for women's involvement in the ethics of science; removal of institutional barriers to advancing women; greater accountability in use of resources; changes in science education; and increased dialogue among those with differing perspectives on the role of science and technology in the advancement of women.

  16. Advances in Materials Science for Environmental and Energy Technologies II

    SciTech Connect

    Matyas, Dr Josef; Ohji, Tatsuki; Liu, Xingbo; Paranthaman, Mariappan Parans; Devanathan, Ram; Fox, Kevin; Singh, Mrityunjay; Wong-ng, Winnie

    2013-01-01

    The Materials Science and Technology 2012 Conference and Exhibition (MS&T'12) was held October 7-11, 2012, in Pittsburgh, Pennsylvania. One of the major themes of the conference was Environmental and Energy Issues. Papers from five of the symposia held under that theme are invluded in this volume. These symposia included Materials Issues in Nuclear Waste Management for the 21st Century; Green Technologies for Materials Manufacturing and Processing IV; Energy Storage: Materials, Systems and Applications; Energy Conversion-Photovoltaic, Concentraing Solar Power and Thermoelectric; and Materials Development for Nuclear Applications and Extreme Environments.

  17. Advancing Global Health – The Need for (Better) Social Science

    PubMed Central

    Hanefeld, Johanna

    2016-01-01

    In his perspective "Navigating between stealth advocacy and unconscious dogmatism: the challenge of researching the norms, politics and power of global health," Ooms argues that actions taken in the field of global health are dependent not only on available resources, but on the normative premise that guides how these resources are spent. This comment sets out how the application of a predominately biomedical positivist research tradition in global health, has potentially limited understanding of the value judgements underlying decisions in the field. To redress this critical social science, including health policy analysis has much to offer, to the field of global health including on questions of governance. PMID:27239873

  18. The muscle oxidative regulatory response to acute exercise is not impaired in less advanced COPD despite a decreased oxidative phenotype.

    PubMed

    Slot, Ilse G M; van den Borst, Bram; Hellwig, Valéry A C V; Barreiro, Esther; Schols, Annemie M W J; Gosker, Harry R

    2014-01-01

    Already in an early disease stage, patients with chronic obstructive pulmonary disease (COPD) are confronted with impaired skeletal muscle function and physical performance due to a loss of oxidative type I muscle fibers and oxidative capacity (i.e. oxidative phenotype; Oxphen). Physical activity is a well-known stimulus of muscle Oxphen and crucial for its maintenance. We hypothesized that a blunted response of Oxphen genes to an acute bout of exercise could contribute to decreased Oxphen in COPD. For this, 28 patients with less advanced COPD (age 65 ± 7 yrs, FEV1 59 ± 16% predicted) and 15 age- and gender-matched healthy controls performed an incremental cycle ergometry test. The Oxphen response to exercise was determined by the measurement of gene expression levels of Oxphen markers in pre and 4h-post exercise quadriceps biopsies. Because exercise-induced hypoxia and oxidative stress may interfere with Oxphen response, oxygen saturation and oxidative stress markers were assessed as well. Regardless of oxygen desaturation and absolute exercise intensities, the Oxphen regulatory response to exercise was comparable between COPD patients and controls with no evidence of increased oxidative stress. In conclusion, the muscle Oxphen regulatory response to acute exercise is not blunted in less advanced COPD, regardless of exercise-induced hypoxia. Hence, this study provides further rationale for incorporation of exercise training as integrated part of disease management to prevent or slow down loss of muscle Oxphen and related functional impairment in COPD. PMID:24587251

  19. REGULATORY REVIEW OF ADVANCED AND INNOVATIVE HUMAN-SYSTEM INTERFACE TECHNOLOGIES.

    SciTech Connect

    O'HARA,J.M.HIGGINS,J.LEWIS,P.PERSENSKY,J.BONGARRA,J.JR.

    2004-09-19

    Given the rapid evolution of digital technology and its inherent flexibility, there may be concern that the regulatory review process could stifle new and innovative approaches to human-system interface (HSI) design even though such innovations may improve operational performance and safety. The U.S. Nuclear Regulatory Commission (NRC) has addressed this concern in recent revisions to its human factors engineering (HFE) review guidance that focuses on the design process as well as the HSI itself. That process has a number of built-in mechanisms to provide a basis to review and accept new approaches to HSI design. These include the use of applicant-specific HSI style guides, the identification of specific criteria for deviating from NRC design review guidelines, and the use of applicant tests and evaluations in lieu of HFE guidelines.

  20. Awareness of the role of science in the FDA regulatory submission process: a survey of the TERMIS-Americas membership.

    PubMed

    Johnson, Peter C; Bertram, Tim A; Carty, Neal R; Hellman, Kiki B; Tawil, Bill J; Van Dyke, Mark

    2014-06-01

    The Industry Committee of the Tissue Engineering Regenerative Medicine International Society, Americas Chapter (TERMIS-AM) administered a survey to its membership in 2013 to assess the awareness of science requirements in the U.S. Food and Drug Administration (FDA) regulatory process. One hundred forty-four members responded to the survey. Their occupational and geographical representation was representative of the TERMIS-AM membership as a whole. The survey elicited basic demographic information, the degree to which members were involved in tissue engineering technology development, and their plans for future involvement in such development. The survey then assessed the awareness of general FDA scientific practices as well as specific science requirements for regulatory submissions to the Center for Biologics Evaluation and Research (CBER), the Center for Drug Evaluation and Research (CDER), the Center for Devices and Radiological Health (CDRH), and the Office of Combination Projects (OCP). The FDA-specific questions in the survey were culled from guidance documents posted on the FDA web site ( www.fda.gov ). One of the answer options was an opt-out clause that enabled survey respondents to claim a lack of sufficient awareness of the topic to answer the question. This enabled the stratification of respondents on the basis of confidence in the topic. Results indicate that across all occupational groups (academic, business, and government) that are represented in the TERMIS-AM membership, the awareness of FDA science requirements varies markedly. Those who performed best were for-profit company employees, consultants, and government employees; while students, professors, and respondents from outside the USA performed least well. Confidence in question topics was associated with increased correctness in responses across all groups, though the association between confidence and the ability to answer correctly was poorest among students and professors. Though 80% of

  1. Advanced Information Technology Investments at the NASA Earth Science Technology Office

    NASA Astrophysics Data System (ADS)

    Clune, T.; Seablom, M. S.; Moe, K.

    2012-12-01

    The NASA Earth Science Technology Office (ESTO) regularly makes investments for nurturing advanced concepts in information technology to enable rapid, low-cost acquisition, processing and visualization of Earth science data in support of future NASA missions and climate change research. In 2012, the National Research Council published a mid-term assessment of the 2007 decadal survey for future spacemissions supporting Earth science and applications [1]. The report stated, "Earth sciences have advanced significantly because of existing observational capabilities and the fruit of past investments, along with advances in data and information systems, computer science, and enabling technologies." The report found that NASA had responded favorably and aggressively to the decadal survey and noted the role of the recent ESTO solicitation for information systems technologies that partnered with the NASA Applied Sciences Program to support the transition into operations. NASA's future missions are key stakeholders for the ESTO technology investments. Also driving these investments is the need for the Agency to properly address questions regarding the prediction, adaptation, and eventual mitigation of climate change. The Earth Science Division has championed interdisciplinary research, recognizing that the Earth must be studied as a complete system in order toaddress key science questions [2]. Information technology investments in the low-mid technology readiness level (TRL) range play a key role in meeting these challenges. ESTO's Advanced Information Systems Technology (AIST) program invests in higher risk / higher reward technologies that solve the most challenging problems of the information processing chain. This includes the space segment, where the information pipeline begins, to the end user, where knowledge is ultimatelyadvanced. The objectives of the program are to reduce the risk, cost, size, and development time of Earth Science space-based and ground

  2. Advanced technology needs for a global change science program: Perspective of the Langley Research Center

    NASA Technical Reports Server (NTRS)

    Rowell, Lawrence F.; Swissler, Thomas J.

    1991-01-01

    The focus of the NASA program in remote sensing is primarily the Earth system science and the monitoring of the Earth global changes. One of NASA's roles is the identification and development of advanced sensing techniques, operational spacecraft, and the many supporting technologies necessary to meet the stringent science requirements. Langley Research Center has identified the elements of its current and proposed advanced technology development program that are relevant to global change science according to three categories: sensors, spacecraft, and information system technologies. These technology proposals are presented as one-page synopses covering scope, objective, approach, readiness timeline, deliverables, and estimated funding. In addition, the global change science requirements and their measurement histories are briefly discussed.

  3. Advanced Gamma-ray Detectors: Science with GRETINA/GRETA

    NASA Astrophysics Data System (ADS)

    Crawford, Heather

    2014-09-01

    In 2007 the NSAC Rare Isotope Beam Task force introduced 17 ``benchmark experimental programs'' to provide a measure of facility performance capabilities for rare-isotope research and to characterize the physics that can be pursued at FRIB. A majority of these topics, and hence the FRIB program and current RIBF programs, will rely on high-resolution, high-efficiency in-flight γ-ray detection. Toward that end, GRETA is proposed to be a high-resolution, high-efficiency 4 π γ-ray spectrometer, consisting of highly segmented germanium detectors grouped in quad-crystal modules. Using pulse shape analysis, the array will be capable of reconstructing the individual interaction points of incident γ-rays. When combined with tracking algorithms, this provides a large increase in sensitivity and resolving power over existing arrays. GRETA, with 30 quad-crystal modules, will allow maximization of the physics opportunities at FRIB, and will play a central role in the science program both with fast-fragmentation and reaccelerated beams. The technology of GRETA, and the capabilities in terms of science have already been demonstrated through the performance of the 1 π spectrometer, GRETINA. Consisting of 7 quad-crystal modules, GRETINA has proven its capabilities in fast-beam experiments at NSCL, a campaign which saw 24 successful experiments which would not have been possible with previous detector technologies. The capabilities of the array in the energy regime of reaccelerated beams is being put to a similar test in the physics campaign currently underway at ANL. The performance and physics accomplishments to date of GRETINA, and a description and path forward to GRETA, the full 4 π tracking array will be discussed. Emphasis will be placed on the role of GRETA or a similar device at facilities like FRIB and RIBF, in terms of experimental capabilities and physics reach. In 2007 the NSAC Rare Isotope Beam Task force introduced 17 ``benchmark experimental programs'' to

  4. Infrastructure Systems for Advanced Computing in E-science applications

    NASA Astrophysics Data System (ADS)

    Terzo, Olivier

    2013-04-01

    In the e-science field are growing needs for having computing infrastructure more dynamic and customizable with a model of use "on demand" that follow the exact request in term of resources and storage capacities. The integration of grid and cloud infrastructure solutions allows us to offer services that can adapt the availability in terms of up scaling and downscaling resources. The main challenges for e-sciences domains will on implement infrastructure solutions for scientific computing that allow to adapt dynamically the demands of computing resources with a strong emphasis on optimizing the use of computing resources for reducing costs of investments. Instrumentation, data volumes, algorithms, analysis contribute to increase the complexity for applications who require high processing power and storage for a limited time and often exceeds the computational resources that equip the majority of laboratories, research Unit in an organization. Very often it is necessary to adapt or even tweak rethink tools, algorithms, and consolidate existing applications through a phase of reverse engineering in order to adapt them to a deployment on Cloud infrastructure. For example, in areas such as rainfall monitoring, meteorological analysis, Hydrometeorology, Climatology Bioinformatics Next Generation Sequencing, Computational Electromagnetic, Radio occultation, the complexity of the analysis raises several issues such as the processing time, the scheduling of tasks of processing, storage of results, a multi users environment. For these reasons, it is necessary to rethink the writing model of E-Science applications in order to be already adapted to exploit the potentiality of cloud computing services through the uses of IaaS, PaaS and SaaS layer. An other important focus is on create/use hybrid infrastructure typically a federation between Private and public cloud, in fact in this way when all resources owned by the organization are all used it will be easy with a federate

  5. First 3 years of operation of RIACS (Research Institute for Advanced Computer Science) (1983-1985)

    NASA Technical Reports Server (NTRS)

    Denning, P. J.

    1986-01-01

    The focus of the Research Institute for Advanced Computer Science (RIACS) is to explore matches between advanced computing architectures and the processes of scientific research. An architecture evaluation of the MIT static dataflow machine, specification of a graphical language for expressing distributed computations, and specification of an expert system for aiding in grid generation for two-dimensional flow problems was initiated. Research projects for 1984 and 1985 are summarized.

  6. Recent advances in applying decision science to managing national forests

    USGS Publications Warehouse

    Marcot, Bruce G.; Thompson, Matthew P.; Runge, Michael C.; Thompson, Frank R.; McNulty, Steven; Cleaves, David; Tomosy, Monica; Fisher, Larry A.; Andrew, Bliss

    2012-01-01

    Management of federal public forests to meet sustainability goals and multiple use regulations is an immense challenge. To succeed, we suggest use of formal decision science procedures and tools in the context of structured decision making (SDM). SDM entails four stages: problem structuring (framing the problem and defining objectives and evaluation criteria), problem analysis (defining alternatives, evaluating likely consequences, identifying key uncertainties, and analyzing tradeoffs), decision point (identifying the preferred alternative), and implementation and monitoring the preferred alternative with adaptive management feedbacks. We list a wide array of models, techniques, and tools available for each stage, and provide three case studies of their selected use in National Forest land management and project plans. Successful use of SDM involves participation by decision-makers, analysts, scientists, and stakeholders. We suggest specific areas for training and instituting SDM to foster transparency, rigor, clarity, and inclusiveness in formal decision processes regarding management of national forests.

  7. Assessment of in vitro COPD models for tobacco regulatory science: Workshop proceedings, conclusions and paths forward for in vitro model use.

    PubMed

    Behrsing, Holger; Raabe, Hans; Manuppello, Joseph; Bombick, Betsy; Curren, Rodger; Sullivan, Kristie; Sethi, Sanjay; Phipps, Richard; Tesfaigzi, Yohannes; Yan, Sherwin; D'Ruiz, Carl; Tarran, Robert; Constant, Samuel; Phillips, Gary; Gaça, Marianna; Hayden, Patrick; Cao, Xuefei; Mathis, Carole; Hoeng, Julia; Braun, Armin; Hill, Erin

    2016-05-01

    The Family Smoking Prevention and Tobacco Control Act of 2009 established the Food and Drug Administration Center for Tobacco Products (FDA-CTP), and gave it regulatory authority over the marketing, manufacture and distribution of tobacco products, including those termed 'modified risk'. On 8-10 December 2014, IIVS organised a workshop conference, entitled Assessment of In Vitro COPD Models for Tobacco Regulatory Science, to bring together stakeholders representing regulatory agencies, academia, industry and animal protection, to address the research priorities articulated by the FDA-CTP. Specific topics were covered to assess the status of current in vitro technologies as they are applied to understanding the adverse pulmonary events resulting from tobacco product exposure, and in particular, the progression of chronic obstructive pulmonary disease (COPD). The four topics covered were: a) Inflammation and Oxidative Stress; b) Ciliary Dysfunction and Ion Transport; c) Goblet Cell Hyperplasia and Mucus Production; and d) Parenchymal/Bronchial Tissue Destruction and Remodelling. The 2.5 day workshop included 18 expert speakers, plus poster sessions, networking and breakout sessions, which identified key findings and provided recommendations to advance the in vitro technologies and assays used to evaluate tobacco-induced disease etiologies. The workshop summary was reported at the 2015 Society of Toxicology Annual Meeting, and the recommendations led to an IIVS-organised technical workshop in June 2015, entitled Goblet Cell Hyperplasia, Mucus Production, and Ciliary Beating Assays, to assess these assays and to conduct a proof-of-principle multi-laboratory exercise to determine their suitability for standardisation. Here, we report on the proceedings, recommendations and outcomes of the December 2014 workshop, including paths forward to continue the development of non-animal methods to evaluate tissue responses that model the disease processes that may lead to COPD, a

  8. The Society for the Advancement of Chicanos and Native Americans in Science (SACNAS) Geoscience Initiative

    NASA Astrophysics Data System (ADS)

    Velasco, A. A.; Lopez, R. E.; Zavala, M.

    2002-12-01

    The Society for the Advancement of Chicanos and Native Americans in Science (SACNAS) focuses on encouraging undergraduate and graduate minority students to pursue higher degrees. For over 29 years, SACNAS has provided strong national leadership in improving science and math education, as well as expanding opportunities for minorities in the scientific workforce and academia. SACNAS' Annual National Conference and Teacher Workshops, summer research opportunities, E-mentoring program, and online internship/job placement resources are tools that help a diverse community of students, professors, administrators, and K-12 educators achieve expertise within their disciplines. The SACNAS Annual National Conference is the centerpiece of our programs. The conferences feature career advancement workshops, scientific symposia, exhibits, student presentations and guest speakers designed to provide the resources Chicano/Latino, Native American, and other postdoctoral, graduate and undergraduate science and engineering students need to pursue a advanced degrees in the sciences. Guest speakers are chosen for their excellence in scientific research and their ability to convey the wonder and importance of science through the presentation of their research results. SACNAS has recently included a geological science emphasis to its existing programs to address the need to diversify the field. This talk will outline our approach, and outline how SACNAS has been able to grow over the past 30 years.

  9. Advances in thin film photonics: materials, science, and technology

    NASA Astrophysics Data System (ADS)

    Fortmann, Charles M.; Tonucci, Ronald J.; Anderson, Wayne A.; Teplin, C. W.; Mahan, A. H.

    2003-10-01

    Control of refractive index in amorphous silicon materials is investigated. Elementary waveguide structures were prepared on two micron thick amorphous silicon by photon lithographic patterning of a silver masking layer. Hydrogen was implanted at fluence of ~5×1017 cm2 for three energies, 50, 100 and 175 KeV yielding a total does of ~1.5×1018 cm2 consistent with a 10% increase in atoms due to the hydrogen addition. The optical properties of the implanted and non-implanted regions were probed as a function of low temperature annealing. The optical band gap shift to higher energy was consistent with hydrogen addition. Some darkening, absorption increase, were noted on the implanted regions. However, low temperature annealing is known to remove dangling bond damage in amorphous silicon. Prospects of utilizing these waveguides to probe light induced optical changes in amorphous silicon is described as well as the prospects of more advanced devices.

  10. Advanced Concept Exploration for Fast Ignition Science Program, Final Report

    SciTech Connect

    Stephens, Richard Burnite; McLean, Harry M.; Theobald, Wolfgang; Akli, Kramer U.; Beg, Farhat N.; Sentoku, Yasuhiko; Schumacher, Douglass W.; Wei, Mingsheng

    2013-09-04

    The Fast Ignition (FI) Concept for Inertial Confinement Fusion (ICF) has the potential to provide a significant advance in the technical attractiveness of Inertial Fusion Energy reactors. FI differs from conventional “central hot spot” (CHS) target ignition by decoupling compression from heating: using a laser (or heavy ion beam or Z pinch) drive pulse (10’s of nanoseconds) to create a dense fuel and a second, much shorter (~10 picoseconds) high intensity pulse to ignite a small volume within the dense fuel. The physics of fast ignition process was the focus of our Advanced Concept Exploration (ACE) program. Ignition depends critically on two major issues involving Relativistic High Energy Density (RHED) physics: The laser-induced creation of fast electrons and their propagation in high-density plasmas. Our program has developed new experimental platforms, diagnostic packages, computer modeling analyses, and taken advantage of the increasing energy available at laser facilities to advance understanding of the fundamental physics underlying these issues. Our program had three thrust areas: • Understand the production and characteristics of fast electrons resulting from FI relevant laser-plasma interactions and their dependence on laser prepulse and laser pulse length. • Investigate the subsequent fast electron transport in solid and through hot (FI-relevant) plasmas. • Conduct and understand integrated core-heating experiments by comparison to simulations. Over the whole period of this project (three years for this contract), we have greatly advanced our fundamental understanding of the underlying properties in all three areas: • Comprehensive studies on fast electron source characteristics have shown that they are controlled by the laser intensity distribution and the topology and plasma density gradient. Laser pre-pulse induced pre-plasma in front of a solid surface results in increased stand-off distances from the electron origin to the high density

  11. Advances in color science: from retina to behavior

    PubMed Central

    Chatterjee, Soumya; Field, Greg D.; Horwitz, Gregory D.; Johnson, Elizabeth N.; Koida, Kowa; Mancuso, Katherine

    2010-01-01

    Color has become a premier model system for understanding how information is processed by neural circuits, and for investigating the relationships among genes, neural circuits and perception. Both the physical stimulus for color and the perceptual output experienced as color are quite well characterized, but the neural mechanisms that underlie the transformation from stimulus to perception are incompletely understood. The past several years have seen important scientific and technical advances that are changing our understanding of these mechanisms. Here, and in the accompanying minisymposium, we review the latest findings and hypotheses regarding color computations in the retina, primary visual cortex and higher-order visual areas, focusing on non-human primates, a model of human color vision. PMID:21068298

  12. "I am Not a Statistic": Identities of African American Males in Advanced Science Courses

    NASA Astrophysics Data System (ADS)

    Johnson, Diane Wynn

    The United States Bureau of Labor Statistics (2010) expects new industries to generate approximately 2.7 million jobs in science and technology by the year 2018, and there is concern as to whether there will be enough trained individuals to fill these positions. A tremendous resource remains untapped, African American students, especially African American males (National Science Foundation, 2009). Historically, African American males have been omitted from the so called science pipeline. Fewer African American males pursue a science discipline due, in part; to limiting factors they experience in school and at home (Ogbu, 2004). This is a case study of African American males who are enrolled in advanced science courses at a predominantly African American (84%) urban high school. Guided by expectancy-value theory (EVT) of achievement related results (Eccles, 2009; Eccles et al., 1983), twelve African American male students in two advanced science courses were observed in their science classrooms weekly, participated in an in-depth interview, developed a presentation to share with students enrolled in a tenth grade science course, responded to an open-ended identity questionnaire, and were surveyed about their perceptions of school. Additionally, the students' teachers were interviewed, and seven of the students' parents. The interview data analyses highlighted the important role of supportive parents (key socializers) who had high expectations for their sons and who pushed them academically. The students clearly attributed their enrollment in advanced science courses to their high regard for their science teachers, which included positive relationships, hands-on learning in class, and an inviting and encouraging learning environment. Additionally, other family members and coaches played important roles in these young men's lives. Students' PowerPoint(c) presentations to younger high school students on why they should take advanced science courses highlighted these

  13. Science Highlights from the First Year of Advanced Camera for Surveys

    NASA Technical Reports Server (NTRS)

    Clampin, M.; Ford, H. C.; Illingworth, G. D.; Hartig, G.; Ardila, D. R.; Blakeslee, J. P.; Bouwens, R. J.; Cross, N. J. G.; Feldman, P. D.; Golimowski, D. A.

    2003-01-01

    The Advanced Camera for Surveys (ACS) is a deep imaging camera installed on the Hubble Space Telescope during the fourth HST servicing mission. ACS recently entered its second year of science operations and continues to perform beyond pre-launch expectations. We present science highlights from the ACS Science Team's GTO program. These highlights include the evolution of Z approx. 6 galaxies from deep imaging observations; deep imaging of strongly lensed clusters which have been used to determine cluster mass, and independently constraint the geometry of the Universe; and coronagraphic observations of debris disks.

  14. Earth Institute at Columbia University ADVANCE Program: Addressing Needs for Women in Earth and Environmental Sciences

    NASA Astrophysics Data System (ADS)

    Bell, R. E.; Cane, M.; Mutter, J.; Miller, R.; Pfirman, S.; Laird, J.

    2004-12-01

    The Earth Institute has received a major NSF ADVANCE grant targeted at increasing the participation and advancement of women scientists and engineers in the Academy through institutional transformation. The Earth Institute at Columbia University includes 9 research institutes including Lamont-Doherty Earth Observatory, Center for Environmental Research and Conservation (CERC), Center for International Earth Science Information Network (CIESIN), International Research Institute (IRI) for Climate Prediction, Earth Engineering Center, NASA-Goddard Institute for Space Studies, Center for Risks and Hazards, Center for Globalization and Sustainable Development, and Center for Global Health and Economic Development and six academic departments including Ecology, Evolution and Environmental Biology (E3B, School of Arts and Sciences), Earth and Environmental Engineering (DEEE, School of Engineering and Applied Sciences), Department of Environmental Health (School of Public Health), Department of Earth and Environmental Sciences (DEES, School of Arts and Sciences), Department of International and Public Affairs (School of International and Policy Affairs), and Barnard College Department of Environmental Science. The Earth Institute at Columbia University's ADVANCE program is based both on a study of the status of women at Columbia and research on the progression of women in science elsewhere. The five major targets of the Columbia ADVANCE program are to (1) change the demographics of the faculty through intelligent hiring practices, (2) provide support to women scientists through difficult life transitions including elder care and adoption or birth of a child, (3) enhance mentoring and networking opportunities, (4) implement transparent promotion procedures and policies, and (5) conduct an institutional self study. The Earth Institute ADVANCE program is unique in that it addresses issues that tend to manifest themselves in the earth and environmental fields, such as extended

  15. Basic science breaks through: New therapeutic advances in Parkinson's disease.

    PubMed

    Brundin, Patrik; Atkin, Graham; Lamberts, Jennifer T

    2015-09-15

    Parkinson's disease (PD) is the second most common neurodegenerative disease and is typically associated with progressive motor dysfunction, although PD patients also exhibit a variety of non-motor symptoms. The neuropathological hallmark of PD is intraneuronal inclusions containing primarily α-Synuclein (α-Syn), and several lines of evidence point to α-Syn as a key contributor to disease progression. Thus, basic research in the field of PD is largely focused on understanding the pathogenic properties of α-Syn. Over the past 2 y, these studies helped to identify several novel therapeutic strategies that have the potential to slow PD progression; such strategies include sequestration of extracellular α-Syn through immunotherapy, reduction of α-Syn multimerization or intracellular toxicity, and attenuation of the neuroinflammatory response. This review describes these and other putative therapeutic strategies, together with the basic science research that led to their identification. The current breadth of novel targets for the treatment of PD warrants cautious optimism in the fight against this devastating disease. PMID:26177603

  16. Special Advanced Course for Core Sciences to Bring Up Project Leaders

    NASA Astrophysics Data System (ADS)

    Inagaki, Kenji; Tabata, Nobuhisa; Gofuku, Akio; Harada, Isao; Takada, Jun

    Special Advanced Course for Core Sciences has been introduced recently to Graduate School of Natural Science and Technology, Okayama University, to bring up a project leader. The following points are key education goals in this program : (1) knowledge of core sciences, (2) communication ability by using English, and (3) wide viewpoints for researches. In order to accomplish these goals, several lectures for core sciences, patent systems and engineering ethics as well as long term internships by the collaboration with some regional companies have been put in practice. In this paper, we describe the outline of the program, educational effects, and our experiences. Then, we discuss how effective the program is for bringing up an engineer or a scientist who can lead sciences and technologies of their domains. This paper also describes current activities of the program.

  17. Soil Erosion: Advanced Crop and Soil Science. A Course of Study.

    ERIC Educational Resources Information Center

    Miller, Larry E.

    The course of study represents the last of six modules in advanced crop and soil science and introduces the agriculture student to the topic of soil erosion. Upon completion of the two day lesson, the student will be able to: (1) define conservation, (2) understand how erosion takes place, and (3) list ways of controlling wind and water erosion.…

  18. What Is Soil? Advanced Crop and Soil Science. A Course of Study.

    ERIC Educational Resources Information Center

    Miller, Larry E.

    The course of study represents the first of six modules in advanced crop and soil science and introduces the agriculture student to the topic of soil management. Upon completing the two day lesson, the student will be able to define "soil", list the soil forming agencies, define and use soil terminology, and discuss soil formation and what makes…

  19. 78 FR 50069 - National Center for Advancing Translational Sciences; Notice of Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Advancing Translational Sciences; Notice of Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of meetings of...

  20. 77 FR 29673 - National Center for Advancing Translational Sciences; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Advancing Translational Sciences; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of...

  1. Physical Features of Soil: Advanced Crop and Soil Science. A Course of Study.

    ERIC Educational Resources Information Center

    Miller, Larry E.

    The course of study represents the second of six modules in advanced crop and soil science and introduces the agriculture student to the subject of physical features of the soil. Upon completing the two day lesson, the student will be able to determine the texture and structural types of soil, list the structural classes of the soil and where they…

  2. Biological Features of the Soil: Advanced Crop and Soil Science. A Course of Study.

    ERIC Educational Resources Information Center

    Miller, Larry E.

    The course of study represents the third of six modules in advanced crop and soil science and introduces the agriculture student to biological features of soil. Upon completing the two day lesson, the student will: (1) realize the vast amount of life present in the soil, (2) be able to list representative animal and plant life in the soil by size,…

  3. Advancing the Science of Recruitment and Retention of Ethnically Diverse Populations

    ERIC Educational Resources Information Center

    Napoles, Anna M.; Chadiha, Letha A.

    2011-01-01

    We highlight several critical challenges that must be addressed to accelerate the advancement of the science on recruitment and retention of ethnically diverse older adults into health research. These include the relative lack of attention by researchers to methodological issues related to recruitment and retention of ethnically diverse…

  4. PARTNERING WITH DOE TO APPLY ADVANCED BIOLOGICAL, ENVIRONMENTAL, AND COMPUTATIONAL SCIENCE TO ENVIRONMENTAL ISSUES

    EPA Science Inventory

    On February 18, 2004, the U.S. Environmental Protection Agency and Department of Energy signed a Memorandum of Understanding to expand the research collaboration of both agencies to advance biological, environmental, and computational sciences for protecting human health and the ...

  5. Using Digital Globes to Explore the Deep Sea and Advance Public Literacy in Earth System Science

    ERIC Educational Resources Information Center

    Beaulieu, Stace E.; Emery, Emery; Brickley, Annette; Spargo, Abbey; Patterson, Kathleen; Joyce, Katherine; Silva, Tim; Madin, Katherine

    2015-01-01

    Digital globes are new technologies increasingly used in informal and formal education to display global datasets and show connections among Earth systems. But how effective are digital globes in advancing public literacy in Earth system science? We addressed this question by developing new content for digital globes with the intent to educate and…

  6. Soil Water: Advanced Crop and Soil Science. A Course of Study.

    ERIC Educational Resources Information Center

    Miller, Larry E.

    The course of study represents the fourth of six modules in advanced crop and soil science and introduces the agriculture student to the topic of soil water. Upon completing the three day module, the student will be able to classify water as to its presence in the soil, outline the hydrological cycle, list the ways water is lost from the soil,…

  7. Advanced Technologies as Educational Tools in Science: Concepts, Applications, and Issues. Monograph Series Number 8.

    ERIC Educational Resources Information Center

    Kumar, David D.; And Others

    Systems incorporating two advanced technologies, hypermedia systems and intelligent tutors, are examined with respect to their potential impact on science education. The conceptual framework underlying these systems is discussed first. Applications of systems are then presented with examples of each in operation within the context of science…

  8. Advancing K-8 Teachers' STEM Education for Teaching Interdisciplinary Science and Mathematics with Technologies

    ERIC Educational Resources Information Center

    Niess, Margaret; Gillow-Wiles, Henry

    2013-01-01

    This primarily online Master's degree program focused on advancing K-8 teachers' interdisciplinary mathematical and science content knowledge while integrating appropriate digital technologies as learning and teaching tools. The mixed-method, interpretive study examined in-service teachers' technological, pedagogical, and content knowledge (TPACK)…

  9. Advances in Laser/Lidar Technologies for NASA's Science and Exploration Mission's Applications

    NASA Technical Reports Server (NTRS)

    Singh, Upendra N.; Kavaya, Michael J.

    2005-01-01

    NASA's Laser Risk Reduction Program, begun in 2002, has achieved many technology advances in only 3.5 years. The recent selection of several lidar proposals for Science and Exploration applications indicates that the LRRP goal of enabling future space-based missions by lowering the technology risk has already begun to be met.

  10. 78 FR 8546 - National Center for Advancing Translational Sciences (NCATS) and National Human Genome Research...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-06

    ...The National Center for Advancing Translational Sciences (NCATS) and the National Human Genome Research Institute (NHGRI), the National Institutes of Health (NIH), are seeking Cooperative Research and Development Agreement (CRADA) partners to collaborate in the final stages of lead optimization, evaluation and preclinical development of a novel selective series of non-inhibitory chaperones of......

  11. 77 FR 37422 - National Center for Advancing Translational Sciences; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Advancing Translational Sciences; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of...

  12. 77 FR 59937 - National Center for Advancing Translational Sciences; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Advancing Translational Sciences; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of...

  13. 78 FR 24223 - National Center for Advancing Translational Sciences; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Advancing Translational Sciences; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of...

  14. The Equity Education. Fostering the Advancement of Women in the Sciences, Mathematics, and Engineering.

    ERIC Educational Resources Information Center

    Davis, Cinda-Sue; And Others

    This volume includes 10 reports that present findings and recommendations for advancing women in science, mathematics and engineering. Critical issues facing women in these disciplines are addressed, including demographic myths and realities at various educational levels; the educational pipeline for girls and women; involvement in education and…

  15. Core Principles and Test Item Development for Advanced High School and Introductory University Level Food Science

    ERIC Educational Resources Information Center

    Laing-Kean, Claudine A. M.

    2010-01-01

    Programs supported by the Carl D. Perkins Act of 2006 are required to operate under the state or national content standards, and are expected to carry out evaluation procedures that address accountability. The Indiana high school course, "Advanced Life Science: Foods" ("ALS: Foods") operates under the auspices of the Perkins Act. However, no broad…

  16. The Advanced Gamma-Ray Imaging System (AGIS): Science Highlights

    SciTech Connect

    Buckley, J.; Coppi, P.; Digel, S.; Funk, S.; Krawczynski, H.; Krennrich, F.; Pohl, M.; Romani, R.; Vassiliev, V.; /UCLA

    2011-11-21

    The Advanced Gamma-ray Imaging System (AGIS), a future gamma-ray telescope consisting of an array of {approx}50 atmospheric Cherenkov telescopes distributed over an area of {approx}1 km{sup 2}, will provide a powerful new tool for exploring the high-energy universe. The order-of-magnitude increase in sensitivity and improved angular resolution could provide the first detailed images of {gamma}-ray emission from other nearby galaxies or galaxy clusters. The large effective area will provide unprecedented sensitivity to short transients (such as flares from AGNs and GRBs) probing both intrinsic spectral variability (revealing the details of the acceleration mechanism and geometry) as well as constraining the high-energy dispersion in the velocity of light (probing the structure of spacetime and Lorentz invariance). A wide field of view ({approx}4 times that of current instruments) and excellent angular resolution (several times better than current instruments) will allow for an unprecedented survey of the Galactic plane, providing a deep unobscured survey of SNRs, X-ray binaries, pulsar-wind nebulae, molecular cloud complexes and other sources. The differential flux sensitivity of {approx}10{sup -13} erg cm{sup -2} sec{sup -1} will rival the most sensitive X-ray instruments for these extended Galactic sources. The excellent capabilities of AGIS at energies below 100 GeV will provide sensitivity to AGN and GRBs out to cosmological redshifts, increasing the number of AGNs detected at high energies from about 20 to more than 100, permitting population studies that will provide valuable insights into both a unified model for AGN and a detailed measurement of the effects of intergalactic absorption from the diffuse extragalactic background light. A new instrument with fast-slewing wide-field telescopes could provide detections of a number of long-duration GRBs providing important physical constraints from this new spectral component. The new array will also have excellent

  17. Science Data Processing for the Advanced Microwave Scanning Radiometer: Earth Observing System

    NASA Technical Reports Server (NTRS)

    Goodman, H. Michael; Regner, Kathryn; Conover, Helen; Ashcroft, Peter; Wentz, Frank; Conway, Dawn; Lobl, Elena; Beaumont, Bruce; Hawkins, Lamar; Jones, Steve

    2004-01-01

    The National Aeronautics and Space Administration established the framework for the Science Investigator-led Processing Systems (SIPS) to enable the Earth science data products to be produced by personnel directly associated with the instrument science team and knowledgeable of the science algorithms. One of the first instantiations implemented for NASA was the Advanced Microwave Scanning Radiometer - Earth Observing System (AMSR-E) SIPS. The AMSR-E SIPS is a decentralized, geographically distributed ground data processing system composed of two primary components located in California and Alabama. Initial science data processing is conducted at Remote Sensing Systems (RSS) in Santa Rosa, California. RSS ingests antenna temperature orbit data sets from JAXA and converts them to calibrated, resampled, geolocated brightness temperatures. The brightness temperatures are sent to the Global Hydrology and Climate Center in Huntsville, Alabama, which generates the geophysical science data products (e.g., water vapor, sea surface temperature, sea ice extent, etc.) suitable for climate research and applications usage. These science products are subsequently sent to the National Snow and Ice Data Center Distributed Active Archive Center in Boulder, Colorado for archival and dissemination to the at-large science community. This paper describes the organization, coordination, and production techniques employed by the AMSR-E SIPS in implementing, automating and operating the distributed data processing system.

  18. 76 FR 71982 - Advancing Regulatory Science for Highly Multiplexed Microbiology/Medical Countermeasure Devices...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-21

    ... the Federal Register of August 8, 2011 (76 FR 48169). In the notice, FDA requested public comments.... 1061, Rockville, MD 20852. FOR FURTHER INFORMATION CONTACT: Raquel Peat, Center for Devices and..., ] MD 20993-0002, (301) 796-6218, email: raquel.peat@fda.hhs.gov . SUPPLEMENTARY INFORMATION:...

  19. Women's Advancement in Political Science. A Report on the APSA Workshop on the Advancement of Women in Academic Political Science in the United States (Washington, DC, March 4-5, 2004)

    ERIC Educational Resources Information Center

    American Political Science Association (NJ1), 2005

    2005-01-01

    In March 2004, the National Science Foundation funded a two-day workshop by the American Political Science Association (APSA) on the advancement of women in academic political science in the United States. The workshop was prompted by an alarming stall in the number of women entering the discipline and persisting through early years of faculty…

  20. Impact of new regulatory standards on advanced practice registered nursing: the APRN Consensus Model and LACE.

    PubMed

    Stanley, Joan M

    2012-06-01

    Advanced practice registered nurses (APRNs) represent a crucial resource to meeting growing health care needs. Such resources must be used to the full extent and in the most effective way possible. Through the development of the Consensus Model for APRN Regulation: Licensure, Accreditation, Certification and Education (LACE), nursing is assuming a leadership role within the health care system and participating as an equal partner in redesigning health care. When fully implemented, the Consensus Model will allow APRNs to practice to the full scope of their education and more easily move from one state to another, increasing access to quality health care for all populations. PMID:22579059

  1. Advanced Technologies for Space Life Science Payloads on the International Space Station

    NASA Technical Reports Server (NTRS)

    Hines, John W.; Connolly, John P. (Technical Monitor)

    1997-01-01

    SENSORS 2000! (S2K!) is a specialized, high-performance work group organized to provide advanced engineering and technology support for NASA's Life Sciences spaceflight and ground-based research and development programs. In support of these objectives, S2K! manages NASA's Advanced Technology Development Program for Biosensor and Biotelemetry Systems (ATD-B), with particular emphasis on technologies suitable for Gravitational Biology, Human Health and Performance, and Information Technology and Systems Management. A concurrent objective is to apply and transition ATD-B developed technologies to external, non-NASA humanitarian (medical, clinical, surgical, and emergency) situations and to stimulate partnering and leveraging with other government agencies, academia, and the commercial/industrial sectors. A phased long-term program has been implemented to support science disciplines and programs requiring specific biosensor (i.e., biopotential, biophysical, biochemical, and biological) measurements from humans, animals (mainly primates and rodents), and cells under controlled laboratory and simulated microgravity situations. In addition to the technology programs described above, NASA's Life and Microgravity Sciences and Applications Office has initiated a Technology Infusion process to identify and coordinate the utilization and integration of advanced technologies into its International Space Station Facilities. This project has recently identified a series of technologies, tasks, and products which, if implemented, would significantly increase the science return, decrease costs, and provide improved technological capability. This presentation will review the programs described above and discuss opportunities for collaboration, leveraging, and partnering with NASA.

  2. The ASP at 125: Advancing Science Literacy in an Age of Acceleration

    NASA Astrophysics Data System (ADS)

    Manning, Jim

    2014-01-01

    On February 7, 2014, the Astronomical Society of the Pacific will celebrate its 125th birthday and a century and a quarter of advancing astronomy and astronomy/science education during a period of revolutionary change in our understanding of the universe. In keeping with both the retrospective and forward-looking nature of such milestones, the presenter will: 1) share highlights of the Society’s work in supporting the communication of astronomy research through its professional publications, and creating innovative astronomy education and public outreach projects and networks to advance student, teacher and public understanding of astronomy and science; 2) report on current NASA- and NSF-funded efforts and on plans going forward; 3) and solicit input from the assembled community on how the ASP can best serve its various constituencies and the cause of science education, communication and literacy at a time when both the universe and life on Earth are accelerating at unprecedented rates. Birthdays are for celebrating; come celebrate with us as we rededicate ourselves to a mission of advancing science literacy through astronomy.

  3. ADVANCING THE SCIENCE OF NATURAL AND ENHANCED ATTENUATION FOR CHLORINATED SOLVENTS

    SciTech Connect

    Looney, B; TOM O. EARLY, T; TYLER GILMORE, T; FRANCIS H. CHAPELLE, F; NORMAN H. CUTSHALL, N; JEFF ROSS, J; MARK ANKENY, M; Michael Heitkamp, M; DAVID MAJOR, D; CHARLES J. NEWELL, C; W. JODY WAUGH, W; GARY WEIN, G; Karen Vangelas, K; Karen-M Adams, K; CLAIRE H. SINK, C

    2006-12-27

    This report summarizes the results of a three-year program that addressed key scientific and technical aspects related to natural and enhanced attenuation of chlorinated organics. The results from this coordinated three-year program support a variety of technical and regulatory advancements. Scientists, regulators, engineers, end-users and stakeholders participated in the program, which was supported by the U.S. Department of Energy (DOE) and the Interstate Technology and Regulatory Council (ITRC). The overarching objective of the effort was to examine environmental remedies that are based on natural processes--remedies such as Monitored Natural Attenuation (MNA) or Enhanced Attenuation (EA). A key result of the recent effort was the general affirmation of the approaches and guidance in the original U.S. Environmental Protection Agency (EPA) chlorinated solvent MNA protocols and directives from 1998 and 1999, respectively. The research program did identify several specific opportunities for advances based on: (1) mass balance as the central framework for attenuation based remedies, (2) scientific advancements and achievements during the past ten years, (3) regulatory and policy development and real-world experience using MNA, and (4) exploration of various ideas for integrating attenuation remedies into a systematic set of ''combined remedies'' for contaminated sites. These opportunities are summarized herein and are addressed in more detail in referenced project documents and journal articles, as well as in the technical and regulatory documents being developed within the ITRC. Natural attenuation processes occur in all soil and groundwater systems and act, to varying degrees, on all contaminants. Thus, a decision to rely on natural attenuation processes as part of a site-remediation strategy does not depend on the occurrence of natural attenuation, but on its effectiveness in meeting site-specific remediation goals. Meeting these goals typically requires low risk

  4. Renewing a Scientific Society: The American Association for the Advancement of Science from World War II to 1970.

    ERIC Educational Resources Information Center

    Wolfle, Dael

    This book recounts the many challenges and successes achieved by the American Association for the Advancement of Science (AAAS) from World War II to 1970. Included are: (1) the development of the National Science Foundation; (2) Cold War concerns about the loyalty and freedom of scientists; (3) efforts to develop an effective science curriculum…

  5. National facility for advanced computational science: A sustainable path to scientific discovery

    SciTech Connect

    Simon, Horst; Kramer, William; Saphir, William; Shalf, John; Bailey, David; Oliker, Leonid; Banda, Michael; McCurdy, C. William; Hules, John; Canning, Andrew; Day, Marc; Colella, Philip; Serafini, David; Wehner, Michael; Nugent, Peter

    2004-04-02

    Lawrence Berkeley National Laboratory (Berkeley Lab) proposes to create a National Facility for Advanced Computational Science (NFACS) and to establish a new partnership between the American computer industry and a national consortium of laboratories, universities, and computing facilities. NFACS will provide leadership-class scientific computing capability to scientists and engineers nationwide, independent of their institutional affiliation or source of funding. This partnership will bring into existence a new class of computational capability in the United States that is optimal for science and will create a sustainable path towards petaflops performance.

  6. Development of Advanced Radioisotope Power Systems for NASA's Future Science Missions

    NASA Astrophysics Data System (ADS)

    Misra, A. K.

    2005-12-01

    This presentation will provide an overview of NASA's current efforts on development of advanced radioisotope power systems (RPS) for future science missions. The current efforts include development of flight qualified Multimission Radioisotope Thermoelectric Generator (MMRTG) and Stirling Radioisotope Generator (SRG) systems with nominal 100 watts power level and capability to operate in both deep space and planetary environments. In addition, advanced technology development efforts are being conducted to increase the specific power of both RTG and SRG systems to enable future science missions. The efforts also include new technologies that have the potential to provide significant increases in specific power of RPS system. A notional RPS technology development roadmap will be presented and various potential mission opportunities identified.

  7. Basic Research Needs for Advanced Nuclear Systems. Report of the Basic Energy Sciences Workshop on Basic Research Needs for Advanced Nuclear Energy Systems, July 31-August 3, 2006

    SciTech Connect

    Roberto, J.; Diaz de la Rubia, T.; Gibala, R.; Zinkle, S.; Miller, J.R.; Pimblott, S.; Burns, C.; Raymond, K.; Grimes, R.; Pasamehmetoglu, K.; Clark, S.; Ewing, R.; Wagner, A.; Yip, S.; Buchanan, M.; Crabtree, G.; Hemminger, J.; Poate, J.; Miller, J.C.; Edelstein, N.; Fitzsimmons, T.; Gruzalski, G.; Michaels, G.; Morss, L.; Peters, M.; Talamini, K.

    2006-10-01

    The global utilization of nuclear energy has come a long way from its humble beginnings in the first sustained nuclear reaction at the University of Chicago in 1942. Today, there are over 440 nuclear reactors in 31 countries producing approximately 16% of the electrical energy used worldwide. In the United States, 104 nuclear reactors currently provide 19% of electrical energy used nationally. The International Atomic Energy Agency projects significant growth in the utilization of nuclear power over the next several decades due to increasing demand for energy and environmental concerns related to emissions from fossil plants. There are 28 new nuclear plants currently under construction including 10 in China, 8 in India, and 4 in Russia. In the United States, there have been notifications to the Nuclear Regulatory Commission of intentions to apply for combined construction and operating licenses for 27 new units over the next decade. The projected growth in nuclear power has focused increasing attention on issues related to the permanent disposal of nuclear waste, the proliferation of nuclear weapons technologies and materials, and the sustainability of a once-through nuclear fuel cycle. In addition, the effective utilization of nuclear power will require continued improvements in nuclear technology, particularly related to safety and efficiency. In all of these areas, the performance of materials and chemical processes under extreme conditions is a limiting factor. The related basic research challenges represent some of the most demanding tests of our fundamental understanding of materials science and chemistry, and they provide significant opportunities for advancing basic science with broad impacts for nuclear reactor materials, fuels, waste forms, and separations techniques. Of particular importance is the role that new nanoscale characterization and computational tools can play in addressing these challenges. These tools, which include DOE synchrotron X

  8. Advanced Risk Reduction Tool (ARRT) Special Case Study Report: Science and Engineering Technical Assessments (SETA) Program

    NASA Technical Reports Server (NTRS)

    Kirsch, Paul J.; Hayes, Jane; Zelinski, Lillian

    2000-01-01

    This special case study report presents the Science and Engineering Technical Assessments (SETA) team's findings for exploring the correlation between the underlying models of Advanced Risk Reduction Tool (ARRT) relative to how it identifies, estimates, and integrates Independent Verification & Validation (IV&V) activities. The special case study was conducted under the provisions of SETA Contract Task Order (CTO) 15 and the approved technical approach documented in the CTO-15 Modification #1 Task Project Plan.

  9. Chemical Features of Soil: Advanced Crop and Soil Science. A Course of Study.

    ERIC Educational Resources Information Center

    Miller, Larry E.

    The course of study represents the fifth of six modules in advanced crop and soil science and introduces the agriculture student to chemical features of the soil. Upon completing the four day lesson, the student will be able to: (1) list macro- and micro-nutrients, (2) define pH and its effect on plants, (3) outline Cation Exchange of the soil,…

  10. The Effect of Nature of Science Metacognitive Prompts on Science Students' Content and Nature of Science Knowledge, Metacognition, and Self-Regulatory Efficacy

    ERIC Educational Resources Information Center

    Peters, Erin; Kitsantas, Anastasia

    2010-01-01

    The purpose of the present explanatory mixed-method design is to examine the effectiveness of a developmental intervention, Embedded Metacognitive Prompts based on Nature of Science (EMPNOS) to teach the nature of science using metacognitive prompts embedded in an inquiry unit. Eighty-three (N = 83) eighth-grade students from four classrooms were…

  11. Advanced Concepts, Technologies and Flight Experiments for NASA's Earth Science Enterprise

    NASA Technical Reports Server (NTRS)

    Meredith, Barry D.

    2000-01-01

    Over the last 25 years, NASA Langley Research Center (LaRC) has established a tradition of excellence in scientific research and leading-edge system developments, which have contributed to improved scientific understanding of our Earth system. Specifically, LaRC advances knowledge of atmospheric processes to enable proactive climate prediction and, in that role, develops first-of-a-kind atmospheric sensing capabilities that permit a variety of new measurements to be made within a constrained enterprise budget. These advances are enabled by the timely development and infusion of new, state-of-the-art (SOA), active and passive instrument and sensor technologies. In addition, LaRC's center-of-excellence in structures and materials is being applied to the technological challenges of reducing measurement system size, mass, and cost through the development and use of space-durable materials; lightweight, multi-functional structures; and large deployable/inflatable structures. NASA Langley is engaged in advancing these technologies across the full range of readiness levels from concept, to components, to prototypes, to flight experiments, and on to actual science mission infusion. The purpose of this paper is to describe current activities and capabilities, recent achievements, and future plans of the integrated science, engineering, and technology team at Langley Research Center who are working to enable the future of NASA's Earth Science Enterprise.

  12. Advanced information science and object-oriented technology for information management applications

    SciTech Connect

    Hummel, J.R.; Swietlik, C.E.

    1996-10-01

    The role of the military has been undergoing rapid change since the fall of the Berlin Wall. The kinds of missions the US military has been asked to participate in have often fallen into the category of {open_quotes}Military Operations Other Than War{close_quotes} and those involving military responses have been more of a surgical nature directed against different kinds of threats, like rogue states or in response to terrorist actions. As a result, the requirements on the military planner and analyst have also had to change dramatically. For example, preparing response options now requires rapid turnaround and a highly flexible simulation capability. This in turn requires that the planner or analyst have access to sophisticated information science and simulation technologies. In this paper, we shall discuss how advanced information science and object-oriented technologies can be used in advanced information management applications. We shall also discuss how these technologies and tools can be applied to DoD applications by presenting examples with a system developed at Argonne, the Dynamic Information Architecture System (DIAS). DIAS has been developed to exploit advanced information science and simulation technologies to provide tools for future planners and analysts.

  13. Consortium of Universities for the Advancement of Hydrologic Science Inc. (CUAHSI) Science Plan: A Community-based Infrastructure Initiative

    NASA Astrophysics Data System (ADS)

    Wilson, J. L.; Dressler, K.; Hooper, R. P.

    2005-12-01

    The river basin is a fundamental unit of the landscape and water in that defined landscape plays a central role in shaping the land surface, in dissolving minerals, in transporting chemicals, and in determining species distribution. Therefore, the river basin is a natural observatory for examining hydrologic phenomena and the complex interaction of physical, chemical, and biological processes that control them. CUAHSI, incorporated in 2001, is a community-based research infrastructure initiative formed to mobilize the hydrologic community through addressing key science questions and leveraging nationwide hydrologic resources from its member institutions and collaborative partners. Through an iterative community-based process, it has been previously proposed to develop a network of hydrologic infrastructure that organizes around scales on the order of 10,000 km2 to examine critical interfaces such as the land-surface, atmosphere, and human impact. Data collection will characterize the stores, fluxes, physical pathways, and residence time distributions of water, sediment, nutrients, and contaminants coherently at nested scales. These fundamental properties can be used by a wide range of scientific disciplines to address environmental questions. This more complete characterization will enable new linkages to be identified and hypotheses to be tested more incisively. With such a research platform, hydrologic science can advance beyond measuring streamflow or precipitation input to understanding how the river basin functions in both its internal processes and in responding to environmental stressors. That predictive understanding is needed to make informed decisions as development and even natural pressures stress existing water supplies and competing demands for water require non-traditional solutions that take into consideration economic, environmental, and social factors. Advanced hydrologic infrastructure will enable research for a broad range of multidisciplinary

  14. Joseph F. Keithley Award For Advances in Measurement Science: Resonant Ultrasound Spectroscopy: An Odyssey in Measurement Science

    NASA Astrophysics Data System (ADS)

    Migliori, Albert

    Perhaps the speeds of sound, or, equivalently, the elastic moduli are some of the most fundamental attributes of a solid, connecting to fundamental physics, metallurgy, non-destructive testing, and more. Unlike most of the quantities used to characterize condensed matter, the elastic moduli are fourth-rank tensors containing a wealth of detail, directional information, and consistency constraints that provide some of the most revealing probes of solids. We describe here the current state of the art in one method, Resonant Ultrasound Spectroscopy, where the mechanical resonances of a specimen of regular shape (easy to measure) are analyzed (difficult computational problem) to obtain the full elastic tensor. With modern advances in electronics and analysis, fractions of a part per million changes in elastic moduli are detectable providing new and important insight into grand challenges in condensed matter physics. This work was supported as part of the Materials Science of Actinides, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Basic Energy Sciences under Award # DE-SC0001089.

  15. Advancing the perceptions of the nature of science (NOS): integrating teaching the NOS in a science content course

    NASA Astrophysics Data System (ADS)

    Aflalo, Ester

    2014-09-01

    Background:Understanding the nature of science (NOS) has been a key objective in teaching sciences for many years. Despite the importance of this goal it is, until this day, a complex challenge that we are far from achieving. Purpose:The study was conducted in order to further the understanding of the NOS amongst preservice teachers. It explores the effects of another approach to teaching that combines teaching the NOS in a course of scientific content. Sample and Programmed description:109 preservice teachers studied the course on 'Cell Biology' or the course, 'Introduction to Life Sciences', whose teaching model differs. In addition to the usual subject matter the courses included activities to understand some aspects of the NOS, reflective discussions, as well as historical descriptions of the scientific discoveries and developments pertaining to the course matter. Design and methods:The study has characteristics of action research The perceptions of the NOS amongst preservice teachers were examined prior to, and following, the course. The perceptions were examined through 35 closed questions and one open question. Results:The findings show that following the course, some of the concepts of NOS changed. Naïve and conservative acuity developed into more current perceptions towards the NOS. Similarly, there was greater internalization of the meaning of the NOS and the significance of its teaching. Conclusions:The findings of this research discuss evidence of the importance of combining the teaching of the NOS in scientific courses in order to advance scientific literacy.

  16. "I am Not a Statistic": Identities of African American Males in Advanced Science Courses

    NASA Astrophysics Data System (ADS)

    Johnson, Diane Wynn

    The United States Bureau of Labor Statistics (2010) expects new industries to generate approximately 2.7 million jobs in science and technology by the year 2018, and there is concern as to whether there will be enough trained individuals to fill these positions. A tremendous resource remains untapped, African American students, especially African American males (National Science Foundation, 2009). Historically, African American males have been omitted from the so called science pipeline. Fewer African American males pursue a science discipline due, in part; to limiting factors they experience in school and at home (Ogbu, 2004). This is a case study of African American males who are enrolled in advanced science courses at a predominantly African American (84%) urban high school. Guided by expectancy-value theory (EVT) of achievement related results (Eccles, 2009; Eccles et al., 1983), twelve African American male students in two advanced science courses were observed in their science classrooms weekly, participated in an in-depth interview, developed a presentation to share with students enrolled in a tenth grade science course, responded to an open-ended identity questionnaire, and were surveyed about their perceptions of school. Additionally, the students' teachers were interviewed, and seven of the students' parents. The interview data analyses highlighted the important role of supportive parents (key socializers) who had high expectations for their sons and who pushed them academically. The students clearly attributed their enrollment in advanced science courses to their high regard for their science teachers, which included positive relationships, hands-on learning in class, and an inviting and encouraging learning environment. Additionally, other family members and coaches played important roles in these young men's lives. Students' PowerPoint(c) presentations to younger high school students on why they should take advanced science courses highlighted these

  17. Advancing Environmental Flow Science: Developing Frameworks for Altered Landscapes and Integrating Efforts Across Disciplines

    DOE PAGESBeta

    Brewer, Shannon; McManamay, Ryan A.; Miller, Andrew D.; Mollenhauer, Robert; Worthington, Thomas A.; Arsuffi, Tom

    2016-05-13

    Environmental flows represent a legal mechanism to balance existing and future water uses and sustain non-use values. Here, we identify current challenges, provide examples where they are important, and suggest research advances that would benefit environmental flow science. Specifically, environmental flow science would benefit by (1) developing approaches to address streamflow needs in highly modified landscapes where historic flows do not provide reasonable comparisons, (2) integrating water quality needs where interactions are apparent with quantity but not necessarily the proximate factor of the ecological degradation, especially as frequency and magnitudes of inflows to bays and estuaries, (3) providing a bettermore » understanding of the ecological needs of native species to offset the often unintended consequences of benefiting non-native species or their impact on flows, (4) improving our understanding of the non-use economic value to balance consumptive economic values, and (5) increasing our understanding of the stakeholder socioeconomic spatial distribution of attitudes and perceptions across the landscape. Environmental flow science is still an emerging interdisciplinary field and by integrating socioeconomic disciplines and developing new frameworks to accommodate our altered landscapes, we should help advance environmental flow science and likely increase successful implementation of flow standards.« less

  18. Advancing Environmental Flow Science: Developing Frameworks for Altered Landscapes and Integrating Efforts Across Disciplines

    NASA Astrophysics Data System (ADS)

    Brewer, Shannon K.; McManamay, Ryan A.; Miller, Andrew D.; Mollenhauer, Robert; Worthington, Thomas A.; Arsuffi, Tom

    2016-08-01

    Environmental flows represent a legal mechanism to balance existing and future water uses and sustain non-use values. Here, we identify current challenges, provide examples where they are important, and suggest research advances that would benefit environmental flow science. Specifically, environmental flow science would benefit by (1) developing approaches to address streamflow needs in highly modified landscapes where historic flows do not provide reasonable comparisons, (2) integrating water quality needs where interactions are apparent with quantity but not necessarily the proximate factor of the ecological degradation, especially as frequency and magnitudes of inflows to bays and estuaries, (3) providing a better understanding of the ecological needs of native species to offset the often unintended consequences of benefiting non-native species or their impact on flows, (4) improving our understanding of the non-use economic value to balance consumptive economic values, and (5) increasing our understanding of the stakeholder socioeconomic spatial distribution of attitudes and perceptions across the landscape. Environmental flow science is still an emerging interdisciplinary field and by integrating socioeconomic disciplines and developing new frameworks to accommodate our altered landscapes, we should help advance environmental flow science and likely increase successful implementation of flow standards.

  19. Advancing Environmental Flow Science: Developing Frameworks for Altered Landscapes and Integrating Efforts Across Disciplines.

    PubMed

    Brewer, Shannon K; McManamay, Ryan A; Miller, Andrew D; Mollenhauer, Robert; Worthington, Thomas A; Arsuffi, Tom

    2016-08-01

    Environmental flows represent a legal mechanism to balance existing and future water uses and sustain non-use values. Here, we identify current challenges, provide examples where they are important, and suggest research advances that would benefit environmental flow science. Specifically, environmental flow science would benefit by (1) developing approaches to address streamflow needs in highly modified landscapes where historic flows do not provide reasonable comparisons, (2) integrating water quality needs where interactions are apparent with quantity but not necessarily the proximate factor of the ecological degradation, especially as frequency and magnitudes of inflows to bays and estuaries, (3) providing a better understanding of the ecological needs of native species to offset the often unintended consequences of benefiting non-native species or their impact on flows, (4) improving our understanding of the non-use economic value to balance consumptive economic values, and (5) increasing our understanding of the stakeholder socioeconomic spatial distribution of attitudes and perceptions across the landscape. Environmental flow science is still an emerging interdisciplinary field and by integrating socioeconomic disciplines and developing new frameworks to accommodate our altered landscapes, we should help advance environmental flow science and likely increase successful implementation of flow standards. PMID:27177541

  20. Proceedings: Workshop on advanced mathematics and computer science for power systems analysis

    SciTech Connect

    Esselman, W.H.; Iveson, R.H. )

    1991-08-01

    The Mathematics and Computer Workshop on Power System Analysis was held February 21--22, 1989, in Palo Alto, California. The workshop was the first in a series sponsored by EPRI's Office of Exploratory Research as part of its effort to develop ways in which recent advances in mathematics and computer science can be applied to the problems of the electric utility industry. The purpose of this workshop was to identify research objectives in the field of advanced computational algorithms needed for the application of advanced parallel processing architecture to problems of power system control and operation. Approximately 35 participants heard six presentations on power flow problems, transient stability, power system control, electromagnetic transients, user-machine interfaces, and database management. In the discussions that followed, participants identified five areas warranting further investigation: system load flow analysis, transient power and voltage analysis, structural instability and bifurcation, control systems design, and proximity to instability. 63 refs.

  1. Who Will Do Science? Trends, and Their Causes in Minority and Female Representation among Holders of Advanced Degrees in Science and Mathematics. A Special Report.

    ERIC Educational Resources Information Center

    Berryman, Sue E.

    This paper describes trends in and causes of minority and female representation among holders of advanced science and math degrees. The minority groups studied are Blacks, Hispanic Americans, American Indians, and Asian Americans, all of whom are compared with Whites. The degrees looked at include those in math, the computer sciences, physical…

  2. Advanced Artificial Science. The development of an artificial science and engineering research infrastructure to facilitate innovative computational modeling, analysis, and application to interdisciplinary areas of scientific investigation.

    SciTech Connect

    Saffer, Shelley I.

    2014-12-01

    This is a final report of the DOE award DE-SC0001132, Advanced Artificial Science. The development of an artificial science and engineering research infrastructure to facilitate innovative computational modeling, analysis, and application to interdisciplinary areas of scientific investigation. This document describes the achievements of the goals, and resulting research made possible by this award.

  3. The Society for the Advancement of Chicanos and Native Americans in Science (SACNAS) Geoscience Initiative

    NASA Astrophysics Data System (ADS)

    Velasco, A. A.

    2005-12-01

    The declining number of geoscience students, especially US citizens, threatens the country's future preparedness in natural hazards mitigation, resource development, national security, and education. Furthermore, the geosciences suffer from poor representation among underrepresented groups, even by comparison to other sciences and engineering. Several organizations have been successful in mentoring and recruiting minorities into science. The Society for the Advancement of Chicanos and Native Americans in Science (SACNAS) focuses on encouraging undergraduate and graduate Hispanic and American Indian students to pursue higher degrees. For over 30 years, SACNAS has provided strong national leadership in improving science and math education, as well as expanding opportunities for minorities in the scientific workforce and academia. SACNAS has added a geological science emphasis to its existing programs to address the need to diversify the field, with funding from the National Science Foundation Opportunities for Enhancing Diversity in the Geosciences (OEDG) program. The goals of this initiative are to: (1) recruit 50 Native American and Chicano/Latino undergraduate and graduate students that are performing research in geoscience disciplines each year for the next five years to attend the annual SACNAS Conference; (2) provide students with early mentoring opportunities designed to assist them with their plans for higher education and employment as researchers and educators in the geosciences; (3) sponsor scientific symposia sessions focusing on advances in the geosciences and opportunities available in related fields; (4) Serve as an information resource through the SACNAS web site and monthly e-nouncements for geoscience research opportunities, and disseminate results of initiative; (5) Offer a workshop for K-12 teachers focusing on geosciences and provide mentoring support throughout the year. We are evaluating the effectiveness of the mentoring initiative by tracking

  4. Science based integrated approach to advanced nuclear fuel development - vision, approach, and overview

    SciTech Connect

    Unal, Cetin; Pasamehmetoglu, Kemal; Carmack, Jon

    2010-01-01

    Advancing the performance of Light Water Reactors, Advanced Nuclear Fuel Cycles, and Advanced Rcactors, such as the Next Generation Nuclear Power Plants, requires enhancing our fundamental understanding of fuel and materials behavior under irradiation. The capability to accurately model the nuclear fuel systems is critical. In order to understand specific aspects of the nuclear fuel, fully coupled fuel simulation codes are required to achieve licensing of specific nuclear fuel designs for operation. The backbone of these codes, models, and simulations is a fundamental understanding and predictive capability for simulating the phase and microstructural behavior of the nuclear fuel system materials and matrices. The purpose of this paper is to identify the modeling and simulation approach in order to deliver predictive tools for advanced fuels development. The coordination between experimental nuclear fuel design, development technical experts, and computational fuel modeling and simulation technical experts is a critical aspect of the approach and naturally leads to an integrated, goal-oriented science-based R & D approach and strengthens both the experimental and computational efforts. The Advanced Fuels Campaign (AFC) and Nuclear Energy Advanced Modeling and Simulation (NEAMS) Fuels Integrated Performance and Safety Code (IPSC) are working together to determine experimental data and modeling needs. The primary objective of the NEAMS fuels IPSC project is to deliver a coupled, three-dimensional, predictive computational platform for modeling the fabrication and both normal and abnormal operation of nuclear fuel pins and assemblies, applicable to both existing and future reactor fuel designs. The science based program is pursuing the development of an integrated multi-scale and multi-physics modeling and simulation platform for nuclear fuels. This overview paper discusses the vision, goals and approaches how to develop and implement the new approach.

  5. Research Infrastructure for the Advancement of Hydrologic Science: Planning Highlights and Update

    NASA Astrophysics Data System (ADS)

    Bales, R. C.

    2001-12-01

    In response to the need for research infrastructure in hydrologic sciences, a group of over 35 universities has formed a Consortium of Universities for the Advancement of Hydrologic Science, Inc. (CUAHSI). With support from the U.S. National Science Foundation, CUAHSI has initiated a science planning process aimed at building research infrastructure in three main areas: i) Long Term Hydrologic Observatories, to provide the consistent, integrated, long-term information from point to continental scales ii) a Hydrologic Information System program, to support the data, information, and analysis requirements of the community and iii) a Hydrologic Measurement Technology program to develop and operate state-of-the-art systems and provide support services for hydrologic research. Scientifically, this infrastructure initiative aims to support research to provide new understanding about priority questions in hydrologic and related sciences, including: i) spatial and temporal properties of precipitation and snow processes, ii) surface water generation and transport at scales from hectares to continental-scale basins, iii) linked water, carbon and other chemical cycles, and changes in response to varying temperature, precipitation and land-use patterns, iii) environmental stresses on aquatic and riparian ecosystems related to groundwater pumping and other perturbations, iv) basin-scale subsurface water and solute movement, particularly as related to patterns of precipitation, evapotranspiration and recharge, and v) feedback between regional evaporation and transpiration and patterns of precipitation and humidity. It has become apparent that the science infrastructure in hydrologic and related sciences is currently inadequate to meet many of these priority science questions and societal needs. Specifically, investments are needed to: i) maintain, supplement and upgrade existing field facilities, ii) establish measurement programs that can deliver consistent data over the long

  6. Exploring the Relationship between the Engineering and Physical Sciences and the Health and Life Sciences by Advanced Bibliometric Methods

    PubMed Central

    Waltman, Ludo; van Raan, Anthony F. J.; Smart, Sue

    2014-01-01

    We investigate the extent to which advances in the health and life sciences (HLS) are dependent on research in the engineering and physical sciences (EPS), particularly physics, chemistry, mathematics, and engineering. The analysis combines two different bibliometric approaches. The first approach to analyze the ‘EPS-HLS interface’ is based on term map visualizations of HLS research fields. We consider 16 clinical fields and five life science fields. On the basis of expert judgment, EPS research in these fields is studied by identifying EPS-related terms in the term maps. In the second approach, a large-scale citation-based network analysis is applied to publications from all fields of science. We work with about 22,000 clusters of publications, each representing a topic in the scientific literature. Citation relations are used to identify topics at the EPS-HLS interface. The two approaches complement each other. The advantages of working with textual data compensate for the limitations of working with citation relations and the other way around. An important advantage of working with textual data is in the in-depth qualitative insights it provides. Working with citation relations, on the other hand, yields many relevant quantitative statistics. We find that EPS research contributes to HLS developments mainly in the following five ways: new materials and their properties; chemical methods for analysis and molecular synthesis; imaging of parts of the body as well as of biomaterial surfaces; medical engineering mainly related to imaging, radiation therapy, signal processing technology, and other medical instrumentation; mathematical and statistical methods for data analysis. In our analysis, about 10% of all EPS and HLS publications are classified as being at the EPS-HLS interface. This percentage has remained more or less constant during the past decade. PMID:25360616

  7. Advancing science diplomacy: Indonesia and the US Naval Medical Research Unit.

    PubMed

    Smith, Frank L

    2014-12-01

    Science diplomacy supposedly builds international cooperation through scientific and technical exchange. In practice, however, there are important but often overlooked instances where it might create conflict instead--as with accusations of espionage surrounding the US Naval Medical Research Unit 2 (NAMRU-2) in Indonesia. Did American science diplomacy backfire in Indonesia and, if so, why? Most literature fails to anticipate this possibility, let alone explain it, since science diplomacy is rarely subject to critical analysis. Rather than shun politics or, similarly, simply blame the demise of NAMRU-2 on the military or avian influenza, I consider both the successes and failures of this research unit in the context of Indonesia's transition to democracy and America's legacy from the Cold War. Based on this history, I propose that the effects of science diplomacy depend on strategic communication and exchange, as well as elite influence and material incentives. Therefore, by challenging the conventional wisdom about science diplomacy, NAMRU-2 can help advance the theory and practice of this potentially useful tool of statecraft. PMID:25608440

  8. Advancing precollege science and mathematics education in San Diego County. Progress report, March 1, 1995--June 30, 1996

    SciTech Connect

    Schissel, D.P.

    1996-08-01

    This report discusses advancing precollege science and mathematics education in San Diego Count. Described in this report are: curriculum and teacher development; pre-tour material; facility tour; student workbook; evaluation and assessment; and internet access.

  9. Proposal to DOE Basic Energy Sciences: Ultrafast X-ray science facility at the Advanced Light Source

    SciTech Connect

    Schoenlein, Robert W.; Falcone, Roger W.; Abela, R.; Alivisatos, A.P.; Belkacem, A.; Berrah, N.; Bozek, J.; Bressler, C.; Cavalleri, A.; Chergui, M.; Glover, T.E.; Heimann, P.A.; Hepburn, J.; Larsson, J.; Lee, R.W.; McCusker, J.; Padmore, H.A.; Pattison, P.; Pratt, S.T.; Shank, C.V.; Wark, J.; Chang, Z.; Robin, D.W.; Schlueter, R.D.; Zholents, A.A.; Zolotorev, M.S.

    2001-12-12

    We propose to develop a true user facility for ultrafast x-ray science at the Advanced Light Source. This facility will be unique in the world, and will fill a critical need for the growing ultrafast x-ray research community. The development of this facility builds upon the expertise from long-standing research efforts in ultrafast x-ray spectroscopy and the development of femtosecond x-ray sources and techniques at both the Lawrence Berkeley National Laboratory and at U.C. Berkeley. In particular, the technical feasibility of a femtosecond x-ray beamline at the ALS has already been demonstrated, and existing ultrafast laser technology will enable such a beamline to operate near the practical limit for femtosecond x-ray flux and brightness from a 3rd generation synchrotron.

  10. The TXESS Revolution: A Partnership to Advance Earth and Space Science in Texas

    NASA Astrophysics Data System (ADS)

    Ellins, K. K.; Olson, H. C.; Willis, M.

    2007-12-01

    professional development program developed by TERC and the American Geological Institute with National Science Foundation (NSF) funding; and an online learning forum designed to keep teachers and teacher mentors in contact with facilitators and fellow project-participants between and after training, as well as share best practices and new information. The new capstone course promises to be a rigorous and dynamic change to the way Earth and Space Science has been presented previously anywhere in the U.S. and will provide many opportunities for professional development and the dissemination of suitable Earth and Space Science curriculum. The TXESS Revolution project welcomes opportunities to collaborate with geoscience consortia, programs, organizations and geoscience educators to advance Earth and Space Science in Texas. NSF's Opportunities to Enhance Diversity in the Geosciences program, the Shell Oil Company and the Jackson School of Geosciences are together funding the TXESS Revolution project.

  11. Laser vision: lidar as a transformative tool to advance critical zone science

    NASA Astrophysics Data System (ADS)

    Harpold, A. A.; Marshall, J. A.; Lyon, S. W.; Barnhart, T. B.; Fisher, B. A.; Donovan, M.; Brubaker, K. M.; Crosby, C. J.; Glenn, N. F.; Glennie, C. L.; Kirchner, P. B.; Lam, N.; Mankoff, K. D.; McCreight, J. L.; Molotch, N. P.; Musselman, K. N.; Pelletier, J.; Russo, T.; Sangireddy, H.; Sjöberg, Y.; Swetnam, T.; West, N.

    2015-06-01

    Observation and quantification of the Earth's surface is undergoing a revolutionary change due to the increased spatial resolution and extent afforded by light detection and ranging (lidar) technology. As a consequence, lidar-derived information has led to fundamental discoveries within the individual disciplines of geomorphology, hydrology, and ecology. These disciplines form the cornerstones of critical zone (CZ) science, where researchers study how interactions among the geosphere, hydrosphere, and biosphere shape and maintain the "zone of life", which extends from the top of unweathered bedrock to the top of the vegetation canopy. Fundamental to CZ science is the development of transdisciplinary theories and tools that transcend disciplines and inform other's work, capture new levels of complexity, and create new intellectual outcomes and spaces. Researchers are just beginning to use lidar data sets to answer synergistic, transdisciplinary questions in CZ science, such as how CZ processes co-evolve over long timescales and interact over shorter timescales to create thresholds, shifts in states and fluxes of water, energy, and carbon. The objective of this review is to elucidate the transformative potential of lidar for CZ science to simultaneously allow for quantification of topographic, vegetative, and hydrological processes. A review of 147 peer-reviewed lidar studies highlights a lack of lidar applications for CZ studies as 38 % of the studies were focused in geomorphology, 18 % in hydrology, 32 % in ecology, and the remaining 12 % had an interdisciplinary focus. A handful of exemplar transdisciplinary studies demonstrate lidar data sets that are well-integrated with other observations can lead to fundamental advances in CZ science, such as identification of feedbacks between hydrological and ecological processes over hillslope scales and the synergistic co-evolution of landscape-scale CZ structure due to interactions amongst carbon, energy, and water cycles

  12. Advanced Resources for Catalysis Science; Recommendations for a National Catalysis Research Institute

    SciTech Connect

    Peden, Charles HF.; Ray, Douglas

    2005-10-05

    Catalysis is one of the most valuable contributors to our economy and historically an area where the United States has enjoyed, but is now losing, international leadership. While other countries are stepping up their work in this area, support for advanced catalysis research and development in the U.S. has diminished. Yet, more than ever, innovative and improved catalyst technologies are imperative for new energy production processes to ease our dependence on imported resources, for new energy-efficient and environmentally benign chemical production processes, and for new emission reduction technologies to minimize the environmental impact of an active and growing economy. Addressing growing concerns about the future direction of U.S. catalysis science, experts from the catalysis community met at a workshop to determine and recommend advanced resources needed to address the grand challenges for catalysis research and development. The workshop's primary conclusion: To recapture our position as the leader in catalysis innovation and practice, and promote crucial breakthroughs, the U.S. must establish one or more well-funded and well-equipped National Catalysis Research Institutes competitively selected, centered in the national laboratories and, by charter, networked to other national laboratories, universities, and industry. The Institute(s) will be the center of a national collaboratory that gives catalysis researchers access to the most advanced techniques available in the scientific enterprise. The importance of catalysis to our energy, economic, and environmental security cannot be overemphasized. Catalysis is a vital part of our core industrial infrastructure, as it is integral to chemical processing and petroleum refining, and is critical to proposed advances needed to secure a sustainable energy future. Advances in catalysis could reduce our need for foreign oil by making better use of domestic carbon resources, for example, allowing cost-effective and zero

  13. Clinical implementation of genetic testing in medicine: a US regulatory science perspective.

    PubMed

    Lesko, Lawrence J; Schmidt, Stephan

    2014-04-01

    Heterogeneity of treatment effects in unselected patient populations has stimulated various strategic approaches to reduce variability and uncertainty and improve individualization of drug selection and dosing. The rapid growth of DNA sequencing and related technologies has ramped up progress in interpreting germline and somatic mutations and has begun to reshape medicine, especially in oncology. Over the past decade, regulatory agencies realized that they needed to be proactive and not reactive if personalized medicine was to become a reality. The US Food and Drug Administration, in particular, took steps to nurture the field through peer-reviewed publications, co-sponsoring public workshops and issuing guidance for industry. The following two major approaches to personalized medicine were taken: (i) encouragement of de novo co-development of drug-genetic test combinations by industry; and (ii) retrospective assessment of legacy genetic data for the purpose of updating drug labels. The former strategy has been more successful in getting new targeted therapies to the marketplace with successful adoption, while the latter, as evidenced by the low adoption rate of pharmacogenetic testing, has been less successful. This reflection piece makes clear that several important things need to happen to make personalized medicine diffuse in more geographical areas and among more therapeutic specialties. The debate over clinical utility of genetic tests needs to be resolved with consensus on evidentiary standards. Physicians, as gatekeepers of prescription medicines, need to increase their knowledge of genetics and the application of the information to patient care. An infrastructure needs to be developed to make access to genetic tests and decision-support tools available to primary practitioners and specialists outside major medical centres and metropolitan areas. PMID:24286486

  14. [Translational/regulatory science researches of NIHS for regenerative medicine and cellular therapy products].

    PubMed

    Sato, Yoji

    2014-01-01

    In 2013, the Japanese Diet passed the Regenerative Medicine Promotion Act and the revisions to the Pharmaceutical Affairs Act, which was also renamed as the Therapeutic Products Act (TPA). One of the aims of the new/revised Acts is to promote the development and translation of and access to regenerative/cellular therapies. In the TPA, a product derived from processing cells is categorized as a subgroup of "regenerative medicine, cellular therapy and gene therapy products" (RCGPs), products distinct from pharmaceuticals and medical devices, allowing RCGPs to obtain a conditional and time- limited marketing authorization much earlier than that under the conventional system. To foster not only RCGPs, but also innovative pharmaceuticals and medical devices, the Ministry of Health, Labour and Welfare recently launched Translational Research Program for Innovative Pharmaceuticals, Medical Devices and RCGPs. This mini-review introduces contributions of the National Institute of Health Sciences (NIHS) to research projects on RCGPs in the Program. PMID:25707195

  15. Strategic Alliance to Advanced Technological Education through Enhanced Mathematics, Science, Technology, and English Education at the Secondary Level

    ERIC Educational Resources Information Center

    Scarborough, Jule Dee

    2004-01-01

    This document (book) reports on the Strategic Alliance to Advance Technological Education through Enhanced Mathematics, Science, Technology, and English Education at the Secondary Level, funded by National Science Foundation. It was a collaborative partnership involving the Rockford Public Schools, Rock Valley College, and Northern Illinois…

  16. Misunderstanding the ‘‘nature’’ of co-management: a geography of regulatory science and indigenous knowledges (IK).

    PubMed

    Watson, Annette

    2013-11-01

    Governments, NGOs, and natural scientists have increased research and policy-making collaborations with Indigenous peoples for governing natural resources, including official co-management regimes. However, there is continuing dissatisfaction with such collaborations, and calls for better communication and mutual learning to create more ‘‘adaptive’’ co-management regimes. This, however, requires that both Western and Indigenous knowledge systems be equal participants in the ‘‘co-production’’ of regulatory data. In this article, I examine the power dynamics of one co-management regulatory regime, conducting a multi-sited ethnography of the practices of researching and managing one transnational migratory species, greater white-fronted geese (Anser albifrons frontalis), who nest where Koyukon Athabascans in Alaska, USA, practice subsistence. Analyzing the ethnographic data through the literatures of critical geography, science studies and Indigenous Studies, I describe how the practice of researching for co-management can produce conflict. ‘‘Scaling’’ the data for the co-management regime can marginalize Indigenous understandings of human– environment relations. While Enlightenment-based practices in wildlife biology avoid ‘‘anthropomorphism,’’ Indigenous Studies describes identities that operate through non-modern, deeply imbricated human–nonhuman identities that do not separate ‘‘nature’’ and ‘‘society’’ in making knowledge. Thus, misunderstanding the ‘‘nature’’ of their collaborations causes biologists and managers to measure and research the system in ways that erase how subsistence- based Indigenous groups already ‘‘manage’’ wildlife: by living through their ethical commitments to their fellow beings. At the end of the article, I discuss how managers might learn from these ontological and epistemologicaldifferences to better ‘‘co-produce’’ data for co-management. PMID:23797486

  17. The Advancement of Family Therapy Theory Based on the Science of Self-Organizing Complex Systems.

    NASA Astrophysics Data System (ADS)

    Ramsey-Kemper, Valerie Ann

    1995-01-01

    Problem. The purpose of this study was to review the literature which presents the latest advancements in the field of family therapy theory. Since such advancement has relied on the scientific developments in the study of autopoietic self-organizing complex systems, then the review began with an historical overview of the development of these natural scientific concepts. The study then examined how the latest scientific concepts have been integrated with family therapy practice. The document is built on the theory that individuals are living, complex, self-organizing, autopoietic systems. When individual systems interact with other individual systems (such as in family interaction, or in interaction between therapist and client), then a third system emerges, which is the relationship. It is through interaction in the relationship that transformation of an individual system can occur. Method. The historical antecedents of the field of family therapy were outlined. It was demonstrated, via literature review, that the field of family therapy has traditionally paralleled developments in the hard sciences. Further, it was demonstrated via literature review that the newest understandings of the development of individuals, family systems, and therapeutic systems also parallel recent natural science developments, namely those developments based on the science of self-organizing complex systems. Outcome. The results of the study are twofold. First, the study articulates an expanded theory of the therapist, individual, and family as autopoietic self-organizing complex systems. Second, the study provides an expanded hypothesis which concerns recommendations for future research which will further advance the latest theories of family therapy. More precisely, the expanded hypothesis suggests that qualitative research, rather than quantitative research, is the method of choice for studying the effectiveness of phenomenological therapy.

  18. LSST system analysis and integration task for an advanced science and application space platform

    NASA Technical Reports Server (NTRS)

    1980-01-01

    To support the development of an advanced science and application space platform (ASASP) requirements of a representative set of payloads requiring large separation distances selected from the Science and Applications Space Platform data base. These payloads were a 100 meter diameter atmospheric gravity wave antenna, a 100 meter by 100 meter particle beam injection experiment, a 2 meter diameter, 18 meter long astrometric telescope, and a 15 meter diameter, 35 meter long large ambient deployable IR telescope. A low earth orbit at 500 km altitude and 56 deg inclination was selected as being the best compromise for meeting payload requirements. Platform subsystems were defined which would support the payload requirements and a physical platform concept was developed. Structural system requirements which included utilities accommodation, interface requirements, and platform strength and stiffness requirements were developed. An attitude control system concept was also described. The resultant ASASP concept was analyzed and technological developments deemed necessary in the area of large space systems were recommended.

  19. Soft x-ray spectromicroscopy development for materials science at the Advanced Light Source

    SciTech Connect

    Warwick, T.; Padmore, H.; Ade, H.; Hitchcock, A.P.; Rightor, E.G.; Tonner, B.P.

    1996-08-01

    Several third generation synchrotron radiation facilities are now operational and the high brightness of these photon sources offers new opportunities for x-ray microscopy. Well developed synchrotron radiation spectroscopy techniques are being applied in new instruments capable of imaging the surface of a material with a spatial resolution smaller than one micron. There are two aspects to this. One is to further the field of surface science by exploring the effects of spatial variations across a surface on a scale not previously accessible to x-ray measurements. The other is to open up new analytical techniques in materials science using x-rays, on a spatial scale comparable to that of the processes or devices to be studied. The development of the spectromicroscopy program at the Advanced Light Source will employ a variety of instruments, some are already operational. Their development and use will be discussed, and recent results will be presented to illustrate their capabilities.

  20. Advances in Applying Treatment Integrity Research for Dissemination and Implementation Science: Introduction to Special Issue

    PubMed Central

    Southam-Gerow, Michael A.; McLeod, Bryce D.

    2013-01-01

    This special series focuses upon the ways in which research on treatment integrity, a multidimensional construct including assessment of the content and quality of a psychosocial treatment delivered to a client as well as relational elements, can inform dissemination and implementation science. The five articles for this special series illustrate how treatment integrity concepts and methods can be applied across different levels of the mental health service system to advance dissemination and implementation science. In this introductory article, we provide an overview of treatment integrity research and describe three broad conceptual models that are relevant to the articles in the series. We conclude with a brief description of each of the five articles in the series. PMID:23970819

  1. The Advanced Technology Large Aperture Space Telescope (ATLAST): Science Drivers and Technology Developments

    NASA Technical Reports Server (NTRS)

    Postman, Marc; Brown, Tom; Sembach, Kenneth; Giavalisco, Mauro; Traub, Wesley; Stapelfeldt, Karl; Calzetti, Daniela; Oegerle, William; Rich, R. Michael; Stahl, H. Phillip; Tumlinson, Jason; Mountain, Matt; Soummer, Remi; Hyde, Tupper

    2011-01-01

    The Advanced Technology Large-Aperture Space Telescope (ATLAST) is a concept for an 8-meter to 16-meter UVOIR space observatory for launch in the 2025-2030 era. ATLAST will allow astronomers to answer fundamental questions at the forefront of modern astrophysics, including "Is there life elsewhere in the Galaxy?" We present a range of science drivers and the resulting performance requirements for ATLAST (8 to 16 milliarcsecond angular resolution, diffraction limited imaging at 0.5 m wavelength, minimum collecting area of 45 square meters, high sensitivity to light wavelengths from 0.1 m to 2.4 m, high stability in wavefront sensing and control). We also discuss the priorities for technology development needed to enable the construction of ATLAST for a cost that is comparable to current generation observatory-class space missions. Keywords: Advanced Technology Large-Aperture Space Telescope (ATLAST); ultraviolet/optical space telescopes; astrophysics; astrobiology; technology development.

  2. High Performance Computing Modeling Advances Accelerator Science for High-Energy Physics

    SciTech Connect

    Amundson, James; Macridin, Alexandru; Spentzouris, Panagiotis

    2014-07-28

    The development and optimization of particle accelerators are essential for advancing our understanding of the properties of matter, energy, space, and time. Particle accelerators are complex devices whose behavior involves many physical effects on multiple scales. Therefore, advanced computational tools utilizing high-performance computing are essential for accurately modeling them. In the past decade, the US Department of Energy's SciDAC program has produced accelerator-modeling tools that have been employed to tackle some of the most difficult accelerator science problems. The authors discuss the Synergia framework and its applications to high-intensity particle accelerator physics. Synergia is an accelerator simulation package capable of handling the entire spectrum of beam dynamics simulations. Our authors present Synergia's design principles and its performance on HPC platforms.

  3. High Performance Computing Modeling Advances Accelerator Science for High-Energy Physics

    DOE PAGESBeta

    Amundson, James; Macridin, Alexandru; Spentzouris, Panagiotis

    2014-07-28

    The development and optimization of particle accelerators are essential for advancing our understanding of the properties of matter, energy, space, and time. Particle accelerators are complex devices whose behavior involves many physical effects on multiple scales. Therefore, advanced computational tools utilizing high-performance computing are essential for accurately modeling them. In the past decade, the US Department of Energy's SciDAC program has produced accelerator-modeling tools that have been employed to tackle some of the most difficult accelerator science problems. The authors discuss the Synergia framework and its applications to high-intensity particle accelerator physics. Synergia is an accelerator simulation package capable ofmore » handling the entire spectrum of beam dynamics simulations. Our authors present Synergia's design principles and its performance on HPC platforms.« less

  4. "Discoveries in Planetary Sciences": Slide Sets Highlighting New Advances for Astronomy Educators

    NASA Astrophysics Data System (ADS)

    Brain, David; Schneider, N.; Molaverdikhani, K.; Afsharahmadi, F.

    2012-10-01

    We present two new features of an ongoing effort to bring recent newsworthy advances in planetary science to undergraduate lecture halls. The effort, called 'Discoveries in Planetary Sciences', summarizes selected recently announced discoveries that are 'too new for textbooks' in the form of 3-slide PowerPoint presentations. The first slide describes the discovery, the second slide discusses the underlying planetary science concepts at a level appropriate for students of 'Astronomy 101', and the third presents the big picture implications of the discovery. A fourth slide includes links to associated press releases, images, and primary sources. This effort is generously sponsored by the Division for Planetary Sciences of the American Astronomical Society, and the slide sets are available at http://dps.aas.org/education/dpsdisc/ for download by undergraduate instructors or any interested party. Several new slide sets have just been released, and we summarize the topics covered. The slide sets are also being translated into languages other than English (including Spanish and Farsi), and we will provide an overview of the translation strategy and process. Finally, we will present web statistics on how many people are using the slide sets, as well as individual feedback from educators.

  5. Advanced development of the spectrum sciences Model 5005-TF, single-event test fixture

    SciTech Connect

    Ackermann, M.R.; Browning, J.S. ); Hughlock, B.W. ); Lum, G.K. ); Tsacoyeanes, W.C. Lab., Inc., Cambridge, MA ); Weeks, M.D. )

    1990-09-01

    This report summarizes the advanced development of the Spectrum Sciences Model 5005-TF, Single-Event Test Fixture. The Model 5005-TF uses a Californium-252 (Cf-252) fission-fragment source to test integrated circuits and other devices for the effects of single-event phenomena. Particle identification methods commonly used in high-energy physics research and nuclear engineering have been incorporated into the Model 5005-TF for estimating the particle charge, mass, and energy parameters. All single-event phenomena observed in a device under test (DUT) are correlated with an identified fission fragment, and its linear energy transfer (LET) and range in the semiconductor material of the DUT.

  6. Laser vision: lidar as a transformative tool to advance critical zone science

    NASA Astrophysics Data System (ADS)

    Harpold, A. A.; Marshall, J. A.; Lyon, S. W.; Barnhart, T. B.; Fisher, B.; Donovan, M.; Brubaker, K. M.; Crosby, C. J.; Glenn, N. F.; Glennie, C. L.; Kirchner, P. B.; Lam, N.; Mankoff, K. D.; McCreight, J. L.; Molotch, N. P.; Musselman, K. N.; Pelletier, J.; Russo, T.; Sangireddy, H.; Sjöberg, Y.; Swetnam, T.; West, N.

    2015-01-01

    Laser vision: lidar as a transformative tool to advance critical zone science. Observation and quantification of the Earth surface is undergoing a revolutionary change due to the increased spatial resolution and extent afforded by light detection and ranging (lidar) technology. As a consequence, lidar-derived information has led to fundamental discoveries within the individual disciplines of geomorphology, hydrology, and ecology. These disciplines form the cornerstones of Critical Zone (CZ) science, where researchers study how interactions among the geosphere, hydrosphere, and ecosphere shape and maintain the "zone of life", extending from the groundwater to the vegetation canopy. Lidar holds promise as a transdisciplinary CZ research tool by simultaneously allowing for quantification of topographic, vegetative, and hydrological data. Researchers are just beginning to utilize lidar datasets to answer synergistic questions in CZ science, such as how landforms and soils develop in space and time as a function of the local climate, biota, hydrologic properties, and lithology. This review's objective is to demonstrate the transformative potential of lidar by critically assessing both challenges and opportunities for transdisciplinary lidar applications. A review of 147 peer-reviewed studies utilizing lidar showed that 38 % of the studies were focused in geomorphology, 18 % in hydrology, 32 % in ecology, and the remaining 12 % have an interdisciplinary focus. We find that using lidar to its full potential will require numerous advances across CZ applications, including new and more powerful open-source processing tools, exploiting new lidar acquisition technologies, and improved integration with physically-based models and complementary in situ and remote-sensing observations. We provide a five-year vision to utilize and advocate for the expanded use of lidar datasets to benefit CZ science applications.

  7. Advanced Science/Event-based Data Service Framework at GES DISC

    NASA Astrophysics Data System (ADS)

    Shie, C. L.; Shen, S.; Kempler, S. J.

    2014-12-01

    The NASA Goddard Earth Sciences Data and Information Service Center (GES DISC) has provided numerous Earth science data, information, and services to various research communities and general publics for decades. To maintain an overall fine service including improving serving our users with advanced data services has been our primary goal. We are developing an advanced science/event-based data service framework. The framework aims to effectively provide users with a sophisticatedly integrated data package via user-friendly discovering and selecting a system-preset science/event topic (e.g., hurricane, volcano, etc.) from an in-developing knowledge database of the framework. A data recipe page related to the Hurricane topic has been developed to demo the concept. More showcases of various subjects such as Volcano, Dust Storm, and Forest Fire are also under development. This framework is in developing on top of existing data services at GES DISC, such as Mirador (data search engine), Giovanni (visualization), OPeNDAP, and data recipes. It also involves other data tools, such as Panoply, GrADS, IDL, etc. The Hurricane Sandy (Oct 22-31 2012) event is used here for a sample description. As Hurricane Sandy being selected as a user case, a table containing nine system-preset data variables (i.e., precipitation, winds, sea surface temperature, sea level pressure, air temperature, relative humidity, aerosols, soil moisture and surface runoff, and trace gases) linked to the respective data products with fine temporal and spatial resolutions from various in-house sources is provided. The "bundled" variable data can thus be readily downloaded through Mirador. The in-house Giovanni is accessible for users to acquire quick views of Level 3 (gridded) variables. For Level 2 (swath) or the Giovanni-unavailable Level 3 data, the system provides a link to data recipes that give a how-to guide to read and visualize the data using offline tools, such as Panoply, GrADS, or IDL.

  8. Advancing Earth System Science Literacy and Preparing the Future Geoscience Workforce Through Strategic Investments at the National Science Foundation (Invited)

    NASA Astrophysics Data System (ADS)

    Karsten, J. L.; Patino, L. C.; Rom, E. L.; Weiler, C. S.

    2010-12-01

    The National Science Foundation (NSF) is an independent federal agency created 60 years ago by the U.S. Congress "to promote the progress of science; to advance the national health, prosperity, and welfare; to secure the national defense…" NSF is the primary funding agency in the U.S. to support basic, frontier research across all fields in science, engineering, and education, except for medical sciences. With a FY 2011 budget request of more than $955 million, the NSF Directorate for Geosciences (GEO) is the principle source of federal funding for university-based fundamental research in the geosciences and preparation of the next generation of geoscientists. Since its inception, GEO has supported the education and training of a diverse and talented pool of future scientists, engineers, and technicians in the Earth, Ocean, Atmospheric and Geospatial Sciences sub-fields, through support of graduate research assistants, post-doctoral fellows, and undergraduate research experiences. In the late 1990’s and early 2000’s, GEO initiated several programs that expanded these investments to also support improvements in pre-college and undergraduate geoscience education through a variety of mechanisms (e.g., professional development support for K-12 teachers, development of innovative undergraduate curricula, and scientist-mentored research experiences for elementary and secondary students). In addition to GEO’s Geoscience Education (GeoEd), Opportunities for Enhancing Diversity in the Geosciences (OEDG), Global Learning and Observations to Benefit the Environment (GLOBE), and Geoscience Teacher Training (GEO-Teach) programs, GEO participates in a number of cross-Foundation programs, including the Research Experiences for Undergraduates (REU), Integrative Graduate Education and Research Traineeship (IGERT), Ethics Education in Science and Engineering (EESE), NSF Graduate STEM Fellows in K-12 Education (GK-12), and Partnerships for International Research and Education

  9. PREFACE: APCTP-ASEAN Workshop on Advanced Materials Science and Nanotechnology (AMSN08)

    NASA Astrophysics Data System (ADS)

    Van Hieu, Nguyen

    2009-09-01

    Dear friends To contribute to the enhancement of the international scientific cooperation of the ASEAN countries and in reply to the proposal of the Vietnam Academy of Science and Technology (VAST), the Asia-Pacific Center for Theoretical Physics (APCTP) and the Sub Committee on Materials Science and Technology (SCMST) of the ASEAN Committee of Science and Technology (ASEAN COST) agreed to organize this APCTP-ASEAN Workshop on Advanced Materials Science and Nanotechnology with the participation of the Ministry of Science and Technology of Vietnam, the Vietnam Academy of Science and Technology, Rencontres du Vietnam, the Vietnam Physical Society, the Vietnam National University in Ho Chi Minh City and the Vietnam National University in Hanoi. As well as the participants from 9 of the 10 ASEAN countries and many other countries/regions of APCTP (Australia, China, Chinese Taipei, Japan and Korea) we warmly welcome the guests from Europe, the United States, Canada and Israel. Without the financial support of the Asia-Pacific Center for Theoretical Physics APCTP, Abdus Salam International Center for Theoretical Physics ICTP, the Asian Office of Aerospace Research and Development AOARD, the US Office of Naval Research Global-Asia ONRG, the Ministry of Science and Technology of Vietnam MOST, the Vietnam Academy of Science and Technology VAST, the Vietnam National University in Ho Chi Minh City VNU HCMC and other Sponsors, we would have been unable to hold this Workshop. On behalf of the International and Local Organizing Committees I would like to express our deep gratitude to the Sponsors. We highly appreciate the support and advice of the members of the International Advisory Committee, the scientific contribution of the invited speakers and all participants. We acknowledge the warm reception of the Khanh Hoa province Administration and citizens, and the hard work of the VAST staff for the success of the Workshop. We cordially wish all participants lively scientific

  10. Advanced placement math and science courses: Influential factors and predictors for success in college STEM majors

    NASA Astrophysics Data System (ADS)

    Hoepner, Cynthia Colon

    President Obama has recently raised awareness on the need for our nation to grow a larger pool of students with knowledge in science mathematics, engineering, and technology (STEM). Currently, while the number of women pursuing college degrees continues to rise, there remains an under-representation of women in STEM majors across the country. Although research studies offer several contributing factors that point to a higher attrition rate of women in STEM than their male counterparts, no study has investigated the role that high school advanced placement (AP) math and science courses play in preparing students for the challenges of college STEM courses. The purpose of this study was to discover which AP math and science courses and/or influential factors could encourage more students, particularly females, to consider pursuing STEM fields in college. Further, this study examined which, if any, AP math or science courses positively contribute to a student's overall preparation for college STEM courses. This retrospective study combined quantitative and qualitative research methods. The survey sample consisted of 881 UCLA female and male students pursuing STEM majors. Qualitative data was gathered from four single-gender student focus groups, two female groups (15 females) and two male groups (16 males). This study examined which AP math and science courses students took in high school, who or what influenced them to take those courses, and which particular courses influenced student's choice of STEM major and/or best prepared her/him for the challenges of STEM courses. Findings reveal that while AP math and science course-taking patterns are similar of female and male STEM students, a significant gender-gap remains in five of the eleven AP courses. Students report four main influences on their choice of AP courses; self, desire for math/science major, higher grade point average or class rank, and college admissions. Further, three AP math and science courses were

  11. Advanced High School Biology in an Era of Rapid Change: A Summary of the Biology Panel Report from the NRC Committee on Programs for Advanced Study of Mathematics and Science in American High Schools

    ERIC Educational Resources Information Center

    Wood, William B.

    2002-01-01

    A recently released National Research Council (NRC) report, "Learning and Understanding: Improving Advanced Study of Mathematics and Science in U.S. High Schools", evaluated and recommended changes in the Advanced Placement (AP), International Baccalaureate (IB), and other advanced secondary school science programs. As part of this study,…

  12. Significant Advances in the AIRS Science Team Version-6 Retrieval Algorithm

    NASA Technical Reports Server (NTRS)

    Susskind, Joel; Blaisdell, John; Iredell, Lena; Molnar, Gyula

    2012-01-01

    AIRS/AMSU is the state of the art infrared and microwave atmospheric sounding system flying aboard EOS Aqua. The Goddard DISC has analyzed AIRS/AMSU observations, covering the period September 2002 until the present, using the AIRS Science Team Version-S retrieval algorithm. These products have been used by many researchers to make significant advances in both climate and weather applications. The AIRS Science Team Version-6 Retrieval, which will become operation in mid-20l2, contains many significant theoretical and practical improvements compared to Version-5 which should further enhance the utility of AIRS products for both climate and weather applications. In particular, major changes have been made with regard to the algOrithms used to 1) derive surface skin temperature and surface spectral emissivity; 2) generate the initial state used to start the retrieval procedure; 3) compute Outgoing Longwave Radiation; and 4) determine Quality Control. This paper will describe these advances found in the AIRS Version-6 retrieval algorithm and demonstrate the improvement of AIRS Version-6 products compared to those obtained using Version-5,

  13. Saudi Arabia: A future regional hub for advanced education, research, science and technology.

    PubMed

    Meo, Sultan Ayoub

    2015-10-01

    Saudi Arabia is the largest country of the Arabian Peninsula, blessed with significant natural resources, including oil, gas and minerals. Saudi Arabia has recognised the importance of education in social and economic transformation, and has established a large number of universities, research and advanced technical institutes which have broken the metropolitan boundaries and have been extended to the far-flung areas of the country. There are 68 universities and degree-awarding institutes. The educational budget reached its highest-ever level of $56.56 billion for the year 2014. About 124,000 Saudi students are pursuing higher education in about 500 universities around the world. Saudi Arabia produced 177826 research papers in Institute for Scientific Information (ISI) database and in the year 2014 alone, 26168 research papers were published in indexed science journals with a rising h-index of 144. The country is turning into a regional hub for advanced education, research, science and technology while swiftly shifting from an oil-based to a knowledge-based economy. PMID:26440844

  14. Advances in astronomy (Scientific session of the Physical Sciences Division of the Russian Academy of Sciences, 27 February 2013)

    NASA Astrophysics Data System (ADS)

    2013-07-01

    A scientific session of the Division of Physical Sciences of the Russian Academy of Sciences (RAS), entitled "Advances in Astronomy" was held on 27 February 2013 at the conference hall of the Lebedev Physical Institute, RAS. The following reports were put on the session agenda posted on the website http://www.gpad.ac.ru of the RAS Physical Sciences Division: (1) Chernin A D (Sternberg Astronomical Institute, Moscow State University, Moscow) "Dark energy in the local Universe: HST data, nonlinear theory, and computer simulations"; (2) Gnedin Yu N (Main (Pulkovo) Astronomical Observatory, RAS, St. Petersburg) "A new method of supermassive black hole studies based on polarimetric observations of active galactic nuclei"; (3) Efremov Yu N (Sternberg Astronomical Institute, Moscow State University, Moscow) "Our Galaxy: grand design and moderately active nucleus"; (4) Gilfanov M R (Space Research Institute, RAS, Moscow) "X-ray binaries, star formation, and type-Ia supernova progenitors"; (5) Balega Yu Yu (Special Astrophysical Observatory, RAS, Nizhnii Arkhyz, Karachaevo-Cherkessia Republic) "The nearest 'star factory' in the Orion Nebula"; (6) Bisikalo D V (Institute of Astronomy, RAS, Moscow) "Atmospheres of giant exoplanets"; (7) Korablev O I (Space Research Institute, RAS, Moscow) "Spectroscopy of the atmospheres of Venus and Mars: new methods and new results"; (8) Ipatov A V (Institute of Applied Astronomy, RAS, St. Petersburg) "A new-generation radio interferometer for fundamental and applied research". Summaries of the papers based on reports 1, 2, 4, 7, 8 are given below. • Dark energy in the nearby Universe: HST data, nonlinear theory, and computer simulations, A D Chernin Physics-Uspekhi, 2013, Volume 56, Number 7, Pages 704-709 • Investigating supermassive black holes: a new method based on the polarimetric observations of active galactic nuclei, Yu N Gnedin Physics-Uspekhi, 2013, Volume 56, Number 7, Pages 709-714 • X-ray binaries and star formation, M R

  15. Data Management Practices and Advanced Technologies in Environmental Science: Lessons from Academia

    NASA Astrophysics Data System (ADS)

    Hernandez, R. R.; Mayernik, M. S.; Murphy-Mariscal, M. L.; Allen, M. F.

    2013-12-01

    Environmental scientists are increasing their capitalization on advancements in technology, computation, and data management. However, the extent of that capitalization is unknown. We analyzed the survey responses of 434 graduate students to evaluate the understanding and use of such advances in the environmental sciences. Two-thirds of the students had not taken courses related to information science and the analysis of complex data. Seventy-four percent of the students reported no skill in programming languages or computational applications. Of the students who had completed research projects, 26% had created metadata for research data sets, and 29% had archived their data so that it was available online. One-third of these students used an environmental sensor. The results differed according to the students' research status, degree type, and university type. Changes may be necessary in the curricula of university programs that seek to prepare environmental scientists for this technologically advanced and data-intensive age. Figure 1. Weighted mean percent of graduate students who had none, basic, proficient, or expert knowledge in programming languages or computational applications. Weights were assigned to university means (n = 23). Error bars are 95% confidence interval. Table 1. Weighted mean percent of graduate students who responded 'YES' they plan to (n = 326) or have already completed (n = 131) research decisions 1-5. Weights were assigned to university means (n = 23). Uncertainties are 95% confidence intervals. Statistical differences are reported between responses of 1) students with thesis/dissertation research ';in progress' and 2) students who have ';completed' their research.

  16. Use of physiologically relevant biopharmaceutics tools within the pharmaceutical industry and in regulatory sciences: Where are we now and what are the gaps?

    PubMed

    Flanagan, Talia; Van Peer, Achiel; Lindahl, Anders

    2016-08-25

    Regulatory interactions are an important part of the drug development and licensing process. A survey on the use of biopharmaceutical tools for regulatory purposes has been carried out within the industry community of the EU project OrBiTo within Innovative Medicines Initiative (IMI). The aim was to capture current practice and experience in using in vitro and in silico biopharmaceutics tools at various stages of development, what barriers exist or are perceived, and to understand the current gaps in regulatory biopharmaceutics. The survey indicated that biorelevant dissolution testing and physiologically based modelling and simulation are widely applied throughout development to address a number of biopharmaceutics issues. However, data from these in vitro and in silico predictive biopharmaceutics tools are submitted to regulatory authorities far less often than they are used for internal risk assessment and decision making. This may prevent regulators from becoming familiar with these tools and how they are applied in industry, and limits the opportunities for biopharmaceutics scientists working in industry to understand the acceptability of these tools in the regulatory environment. It is anticipated that the advanced biopharmaceutics tools and understanding delivered in the next years by OrBiTo and other initiatives in the area of predictive tools will also be of value in the regulatory setting, and provide a basis for more informed and confident biopharmaceutics risk assessment and regulatory decision making. To enable the regulatory potential of predictive biopharmaceutics tools to be realized, further scientific dialogue is needed between industry, regulators and scientists in academia, and more examples need to be published to demonstrate the applicability of these tools. PMID:27283487

  17. Progress toward a Semantic eScience Framework; building on advanced cyberinfrastructure

    NASA Astrophysics Data System (ADS)

    McGuinness, D. L.; Fox, P. A.; West, P.; Rozell, E.; Zednik, S.; Chang, C.

    2010-12-01

    The configurable and extensible semantic eScience framework (SESF) has begun development and implementation of several semantic application components. Extensions and improvements to several ontologies have been made based on distinct interdisciplinary use cases ranging from solar physics, to biologicl and chemical oceanography. Importantly, these semantic representations mediate access to a diverse set of existing and emerging cyberinfrastructure. Among the advances are the population of triple stores with web accessible query services. A triple store is akin to a relational data store where the basic stored unit is a subject-predicate-object tuple. Access via a query is provided by the W3 Recommendation language specification SPARQL. Upon this middle tier of semantic cyberinfrastructure, we have developed several forms of semantic faceted search, including provenance-awareness. We report on the rapid advances in semantic technologies and tools and how we are sustaining the software path for the required technical advances as well as the ontology improvements and increased functionality of the semantic applications including how they are integrated into web-based portals (e.g. Drupal) and web services. Lastly, we indicate future work direction and opportunities for collaboration.

  18. Facilitating career advancement for women in the Geosciences through the Earth Science Women's Network (ESWN)

    NASA Astrophysics Data System (ADS)

    Hastings, M. G.; Kontak, R.; Holloway, T.; Kogan, M.; Laursen, S. L.; Marin-Spiotta, E.; Steiner, A. L.; Wiedinmyer, C.

    2011-12-01

    The Earth Science Women's Network (ESWN) is a network of women geoscientists, many of who are in the early stages of their careers. The mission of ESWN is to promote career development, build community, provide informal mentoring and support, and facilitate professional collaborations, all towards making women successful in their scientific careers. ESWN currently connects over 1000 women across the globe, and includes graduate students, postdoctoral associates, faculty from a diversity of colleges and universities, program managers, and government, non-government and industry researchers. ESWN facilitates communication between its members via an email listserv and in-person networking events, and also provides resources to the broader community through the public Earth Science Jobs Listserv that hosts over 1800 subscribers. With funding from a NSF ADVANCE PAID grant, our primary goals include growing our membership to serve a wider section of the geosciences community, designing and administering career development workshops, promoting professional networking at major scientific conferences, and developing web resources to build connections, collaborations, and peer mentoring for and among women in the Earth Sciences. Recognizing that women in particular face a number of direct and indirect biases while navigating their careers, we aim to provide a range of opportunities for professional development that emphasize different skills at different stages of career. For example, ESWN-hosted mini-workshops at national scientific conferences have targeted skill building for early career researchers (e.g., postdocs, tenure-track faculty), with a recent focus on raising extramural research funding and best practices for publishing in the geosciences literature. More concentrated, multi-day professional development workshops are offered annually with varying themes such as Defining Your Research Identity and Building Leadership Skills for Success in Scientific Organizations

  19. Geospace Science from Ground-based Magnetometer Arrays: Advances in Sensors, Data Collection, and Data Integration

    NASA Astrophysics Data System (ADS)

    Mann, Ian; Chi, Peter

    2016-07-01

    , acceleration, and loss of electrons in the radiation belts promise high profile science returns. Integrated, global scale data products also have potential importance and application for real-time monitoring of the space weather threats to electrical power grids from geomagnetically induced currents. Such data exploitation increasingly relies on the collaborations between multiple national magnetometer arrays to generate single data products with common file format and data properties. We review advances in geospace science which can be delivered by networks of ground-based magnetometers - in terms of advances in sensors, data collection, and data integration - including through collaborations within the Ultra-Large Terrestrial International Magnetometer Array (ULTIMA) consortium.

  20. Community Petascale Project for Accelerator Science and Simulation: Advancing Computational Science for Future Accelerators and Accelerator Technologies

    SciTech Connect

    Spentzouris, P.; Cary, J.; McInnes, L.C.; Mori, W.; Ng, C.; Ng, E.; Ryne, R.; /LBL, Berkeley

    2011-11-14

    The design and performance optimization of particle accelerators are essential for the success of the DOE scientific program in the next decade. Particle accelerators are very complex systems whose accurate description involves a large number of degrees of freedom and requires the inclusion of many physics processes. Building on the success of the SciDAC-1 Accelerator Science and Technology project, the SciDAC-2 Community Petascale Project for Accelerator Science and Simulation (ComPASS) is developing a comprehensive set of interoperable components for beam dynamics, electromagnetics, electron cooling, and laser/plasma acceleration modelling. ComPASS is providing accelerator scientists the tools required to enable the necessary accelerator simulation paradigm shift from high-fidelity single physics process modeling (covered under SciDAC1) to high-fidelity multiphysics modeling. Our computational frameworks have been used to model the behavior of a large number of accelerators and accelerator R&D experiments, assisting both their design and performance optimization. As parallel computational applications, the ComPASS codes have been shown to make effective use of thousands of processors. ComPASS is in the first year of executing its plan to develop the next-generation HPC accelerator modeling tools. ComPASS aims to develop an integrated simulation environment that will utilize existing and new accelerator physics modules with petascale capabilities, by employing modern computing and solver technologies. The ComPASS vision is to deliver to accelerator scientists a virtual accelerator and virtual prototyping modeling environment, with the necessary multiphysics, multiscale capabilities. The plan for this development includes delivering accelerator modeling applications appropriate for each stage of the ComPASS software evolution. Such applications are already being used to address challenging problems in accelerator design and optimization. The ComPASS organization

  1. NUCLEAR DATA NEEDS FOR ADVANCED REACTOR SYSTEMS. A NEA NUCLEAR SCIENCE COMMITTEE INITIATIVE.

    SciTech Connect

    SALVATORES,J.M.; ALIBERTI, G.; PALMIOTTI, G.; ROCHMAN, D.; OBLOZINSKY, P.; HERMANN, M.; TALOU, P.; KAWANO, T.; LEAL, L.; KONING, A.; KODELI, I.

    2007-04-22

    The Working Party on Evaluation Cooperation (WPEC) of the OECD Nuclear Energy Agency Nuclear Science Committee has established an International Subgroup to perform an activity in order to develop a systematic approach to define data needs for Gen-IV and, in general, for advanced reactor systems. A methodology, based on sensitivity analysis has been agreed and representative core configurations for Sodium, Gas and Lead cooled Fast Reactors (SFR, GFR, LFR) have been defined as well as a high burn-up VHTR and a high burn-up PWR. In the case of SFRs, both a TRU burner (called in fact SFR) and a core configuration with homogeneous recycling of not separated TRU (called EFR) have been considered.

  2. Effects of the Integrated Online Advance Organizer Teaching Materials on Students' Science Achievement and Attitude

    NASA Astrophysics Data System (ADS)

    Korur, Fikret; Toker, Sacip; Eryılmaz, Ali

    2016-08-01

    This two-group quasi-experimental study investigated the effects of the Online Advance Organizer Concept Teaching Material (ONACOM) integrated with inquiry teaching and expository teaching methods. Grade 7 students' posttest performances on the light unit achievement and light unit attitude tests controlled for gender, previous semester science grade, and pretest scores were analyzed. No significant treatment effects were found between the inquiry and expository approaches. However, both groups demonstrated significant pretest-posttest gains in achievement and attitude. Independent from the method used, ONACOM was judged effective in both groups as students demonstrated increased achievement and attitude scores. ONACOM has a social and semantic network-aided infrastructure that can be adapted to both methods to increase students' achievement and improve their attitude.

  3. Advanced Technology Large-Aperture Space Telescope: Science Drivers and Technology Developments

    NASA Technical Reports Server (NTRS)

    Postman, Marc; Brown, Tom; Sembach, Kenneth; Glavallsco, Mauro; Traub, Wesley; Stapelfeldt, Karl; Calzetti, Daniela; Oegerle, William; Rich, R. Michael; Stahl, H. Philip; Tumlinson, Jason; Mountain, Matt; Soummer, Remi; Hyde, Tupper

    2012-01-01

    The Advanced Technology Large-Aperture Space Telescope (ATLAST) is a concept for an 8- to 16-m ultraviolet optical near Infrared space observatory for launch in the 2025 to 2030 era. ATLAST will allow astronomers to answer fundamental questions at the forefront of modern astrophysics, including: Is there life elsewhere in the Galaxy? We present a range of science drivers and the resulting performance requirements for ATLAST (8- to 16-marcsec angular resolution, diffraction limited imaging at 0.5 micron wavelength, minimum collecting area of 45 sq m, high sensitivity to light wavelengths from 0.1 to 2.4 micron, high stability in wavefront sensing and control). We also discuss the priorities for technology development needed to enable the construction of ATLAST for a cost that is comparable to that of current generation observatory-class space missions.

  4. Community-based participatory research as a tool to advance environmental health sciences.

    PubMed Central

    O'Fallon, Liam R; Dearry, Allen

    2002-01-01

    The past two decades have witnessed a rapid proliferation of community-based participatory research (CBPR) projects. CBPR methodology presents an alternative to traditional population-based biomedical research practices by encouraging active and equal partnerships between community members and academic investigators. The National Institute of Environmental Health Sciences (NIEHS), the premier biomedical research facility for environmental health, is a leader in promoting the use of CBPR in instances where community-university partnerships serve to advance our understanding of environmentally related disease. In this article, the authors highlight six key principles of CBPR and describe how these principles are met within specific NIEHS-supported research investigations. These projects demonstrate that community-based participatory research can be an effective tool to enhance our knowledge of the causes and mechanisms of disorders having an environmental etiology, reduce adverse health outcomes through innovative intervention strategies and policy change, and address the environmental health concerns of community residents. PMID:11929724

  5. Advancing the science for active surveillance: rationale and design for the Observational Medical Outcomes Partnership.

    PubMed

    Stang, Paul E; Ryan, Patrick B; Racoosin, Judith A; Overhage, J Marc; Hartzema, Abraham G; Reich, Christian; Welebob, Emily; Scarnecchia, Thomas; Woodcock, Janet

    2010-11-01

    The U.S. Food and Drug Administration (FDA) Amendments Act of 2007 mandated that the FDA develop a system for using automated health care data to identify risks of marketed drugs and other medical products. The Observational Medical Outcomes Partnership is a public-private partnership among the FDA, academia, data owners, and the pharmaceutical industry that is responding to the need to advance the science of active medical product safety surveillance by using existing observational databases. The Observational Medical Outcomes Partnership's transparent, open innovation approach is designed to systematically and empirically study critical governance, data resource, and methodological issues and their interrelationships in establishing a viable national program of active drug safety surveillance by using observational data. This article describes the governance structure, data-access model, methods-testing approach, and technology development of this effort, as well as the work that has been initiated. PMID:21041580

  6. Effects of the Integrated Online Advance Organizer Teaching Materials on Students' Science Achievement and Attitude

    NASA Astrophysics Data System (ADS)

    Korur, Fikret; Toker, Sacip; Eryılmaz, Ali

    2016-03-01

    This two-group quasi-experimental study investigated the effects of the Online Advance Organizer Concept Teaching Material (ONACOM) integrated with inquiry teaching and expository teaching methods. Grade 7 students' posttest performances on the light unit achievement and light unit attitude tests controlled for gender, previous semester science grade, and pretest scores were analyzed. No significant treatment effects were found between the inquiry and expository approaches. However, both groups demonstrated significant pretest-posttest gains in achievement and attitude. Independent from the method used, ONACOM was judged effective in both groups as students demonstrated increased achievement and attitude scores. ONACOM has a social and semantic network-aided infrastructure that can be adapted to both methods to increase students' achievement and improve their attitude.

  7. Science and Technology to Advance Regional Security in the Middle East and Central Asia

    SciTech Connect

    Tompson, A F B; Richardson, J H; Ragaini, R C; Knapp, R B; Rosenberg, N D; Smith, D K; Ball, D Y

    2002-10-09

    This paper is concerned with the promotion and advancement of regional security in the Middle East and Central Asia through the development of bilateral and multilateral cooperation on targeted scientific and technical projects. It is widely recognized that increasing tensions and instability in many parts of the world emphasize--or reemphasize--a need to seek and promote regional security in these areas. At the Lawrence Livermore National Laboratory (LLNL), a national security research facility operated for the US Department of Energy, we are pursuing an effort to use science and technology as a ''low risk'' means of engagement in regions of strategic importance to the United States. In particular, we are developing collaborations and cooperative projects among (and between) national laboratory scientists in the US and our various counterparts in the countries of interest.

  8. A NATIONAL COLLABORATORY TO ADVANCE THE SCIENCE OF HIGH TEMPERATURE PLASMA PHYSICS FOR MAGNETIC FUSION

    SciTech Connect

    Allen R. Sanderson; Christopher R. Johnson

    2006-08-01

    This report summarizes the work of the University of Utah, which was a member of the National Fusion Collaboratory (NFC) Project funded by the United States Department of Energy (DOE) under the Scientific Discovery through Advanced Computing Program (SciDAC) to develop a persistent infrastructure to enable scientific collaboration for magnetic fusion research. A five year project that was initiated in 2001, it the NFC built on the past collaborative work performed within the U.S. fusion community and added the component of computer science research done with the USDOE Office of Science, Office of Advanced Scientific Computer Research. The project was itself a collaboration, itself uniting fusion scientists from General Atomics, MIT, and PPPL and computer scientists from ANL, LBNL, and Princeton University, and the University of Utah to form a coordinated team. The group leveraged existing computer science technology where possible and extended or created new capabilities where required. The complete finial report is attached as an addendum. The In the collaboration, the primary technical responsibility of the University of Utah in the collaboration was to develop and deploy an advanced scientific visualization service. To achieve this goal, the SCIRun Problem Solving Environment (PSE) is used on FusionGrid for an advanced scientific visualization service. SCIRun is open source software that gives the user the ability to create complex 3D visualizations and 2D graphics. This capability allows for the exploration of complex simulation results and the comparison of simulation and experimental data. SCIRun on FusionGrid gives the scientist a no-license-cost visualization capability that rivals present day commercial visualization packages. To accelerate the usage of SCIRun within the fusion community, a stand-alone application built on top of SCIRun was developed and deployed. This application, FusionViewer, allows users who are unfamiliar with SCIRun to quickly create

  9. Research Institute for Advanced Computer Science: Annual Report October 1998 through September 1999

    NASA Technical Reports Server (NTRS)

    Leiner, Barry M.; Gross, Anthony R. (Technical Monitor)

    1999-01-01

    The Research Institute for Advanced Computer Science (RIACS) carries out basic research and technology development in computer science, in support of the National Aeronautics and Space Administration's missions. RIACS is located at the NASA Ames Research Center (ARC). It currently operates under a multiple year grant/cooperative agreement that began on October 1, 1997 and is up for renewal in the year 2002. ARC has been designated NASA's Center of Excellence in Information Technology. In this capacity, ARC is charged with the responsibility to build an Information Technology Research Program that is preeminent within NASA. RIACS serves as a bridge between NASA ARC and the academic community, and RIACS scientists and visitors work in close collaboration with NASA scientists. RIACS has the additional goal of broadening the base of researchers in these areas of importance to the nation's space and aeronautics enterprises. RIACS research focuses on the three cornerstones of information technology research necessary to meet the future challenges of NASA missions: (1) Automated Reasoning for Autonomous Systems. Techniques are being developed enabling spacecraft that will be self-guiding and self-correcting to the extent that they will require little or no human intervention. Such craft will be equipped to independently solve problems as they arise, and fulfill their missions with minimum direction from Earth. (2) Human-Centered Computing. Many NASA missions require synergy between humans and computers, with sophisticated computational aids amplifying human cognitive and perceptual abilities; (3) High Performance Computing and Networking Advances in the performance of computing and networking continue to have major impact on a variety of NASA endeavors, ranging from modeling and simulation to data analysis of large datasets to collaborative engineering, planning and execution. In addition, RIACS collaborates with NASA scientists to apply information technology research to

  10. Evaluation of the applicability of existing nuclear power plant regulatory requirements in the U.S. to advanced small modular reactors.

    SciTech Connect

    LaChance, Jeffrey L.; Wheeler, Timothy A.; Farnum, Cathy Ottinger; Middleton, Bobby D.; Jordan, Sabina Erteza; Duran, Felicia Angelica; Baum, Gregory A.

    2013-05-01

    The current wave of small modular reactor (SMR) designs all have the goal of reducing the cost of management and operations. By optimizing the system, the goal is to make these power plants safer, cheaper to operate and maintain, and more secure. In particular, the reduction in plant staffing can result in significant cost savings. The introduction of advanced reactor designs and increased use of advanced automation technologies in existing nuclear power plants will likely change the roles, responsibilities, composition, and size of the crews required to control plant operations. Similarly, certain security staffing requirements for traditional operational nuclear power plants may not be appropriate or necessary for SMRs due to the simpler, safer and more automated design characteristics of SMRs. As a first step in a process to identify where regulatory requirements may be met with reduced staffing and therefore lower cost, this report identifies the regulatory requirements and associated guidance utilized in the licensing of existing reactors. The potential applicability of these regulations to advanced SMR designs is identified taking into account the unique features of these types of reactors.

  11. PREFACE: Advanced Science Research Symposium 2009 Positron, Muon and other exotic particle beams for materials and atomic/molecular sciences (ASR2009)

    NASA Astrophysics Data System (ADS)

    Higemoto, Wataru; Kawasuso, Atsuo

    2010-05-01

    It is our great pleasure to deliver the proceedings of ASR2009, the Advanced Science Research International Symposium 2009. ASR2009 is part of a series of symposia which is hosted by the Japan Atomic Energy Agency, Advanced Science Research Center (JAEA-ASRC), and held every year with different scientific topics. ASR2009 was held at Tokai in Japan from 10-12 November 2009. In total, 102 participants, including 29 overseas scientists, made 44 oral presentations and 64 poster presentations. In ASR2009 we have focused on material and atomic/molecular science research using positrons, muons and other exotic particle beams. The symposium covered all the fields of materials science which use such exotic particle beams. Positrons, muons and other beams have similar and different features. For example, although positrons and muons are both leptons having charge and spin, they give quite different information about materials. A muon mainly detects the local magnetic state of the solid, while a positron detects crystal imperfections and electron momenta in solids. Other exotic particle beams also provide useful information about materials which is not able to be obtained with muons or positrons. Therefore, the complementary use of particle beams, coupled with an understanding of their relative advantages, leads to greater excellence in materials research. This symposium crossed the fields of muon science, positron science, unstable-nuclei science, and other exotic particle-beam science. We therefore believe that ASR2009 became an especially important meeting for finding new science with exotic particle beams. Finally, we would like to extend our appreciation to all the participants, committee members, and support staff for their great efforts to make ASR2009 a fruitful symposium. ASR2009 Chairs Wataru Higemoto and Atsuo Kawasuso Advanced Science Research Center, Japan Atomic Energy Agency Organizing committee Y Hatano, JAEA (Director of ASRC) M Fujinami, Chiba Univ. R H

  12. Advancing the field of pharmaceutical risk minimization through application of implementation science best practices.

    PubMed

    Smith, Meredith Y; Morrato, Elaine

    2014-08-01

    Regulators are increasingly mandating the use of pharmaceutical risk-minimization programs for a variety of medicinal products. To date, however, evaluations of these programs have shown mixed results and relatively little attention has been directed at diagnosing the specific factors contributing to program success or lack thereof. Given the growing use of these programs in many different patient populations, it is imperative to understand how best to design, deliver, disseminate, and assess them. In this paper, we argue that current approaches to designing, implementing, and evaluating risk-minimization programs could be improved by applying evidence- and theory-based 'best practices' from implementation science. We highlight commonly encountered challenges and gaps in the design, implementation, and evaluation of pharmaceutical risk-minimization initiatives and propose three key recommendations to address these issues: (1) risk-minimization program design should utilize models and frameworks that guide what should be done to produce successful outcomes and what questions should be addressed to evaluate program success; (2) intervention activities and tools should be theoretically grounded and evidence based; and (3) evaluation plans should incorporate a mixed-methods approach, pragmatic trial designs, and a range of outcomes. Regulators, practitioners, policy makers, and researchers are encouraged to apply these best practices in order to improve the public health impact of this important regulatory tool. PMID:25005707

  13. Math and Science Partnership Program: Strengthening America by Advancing Academic Achievement in Mathematics and Science. NSF-05-069

    ERIC Educational Resources Information Center

    National Science Foundation, 2006

    2006-01-01

    This booklet presents an overview of the Math Science Partnership program (MSP) at the National Science Foundation (NSF). This program responds to a growing national concern--the educational performance of U.S. children in mathematics and science. Through the MSP, NSF awards competitive, merit-based grants to teams composed of institutions of…

  14. First 3 years of operation of RIACS (Research Institute for Advanced Computer Science) (1983-1985). Final Report

    SciTech Connect

    Denning, P.J.

    1986-04-01

    The focus of the Research Institute for Advanced Computer Science (RIACS) is to explore matches between advanced computing architectures and the processes of scientific research. An architecture evaluation of the MIT static dataflow machine, specification of a graphical language for expressing distributed computations, and specification of an expert system for aiding in grid generation for two-dimensional flow problems was initiated. Research projects for 1984 and 1985 are summarized.

  15. Engaging academia to advance the science and practice of environmental public health tracking

    PubMed Central

    Strosnider, Heather; Zhou, Ying; Balluz, Lina; Qualters, Judith

    2015-01-01

    Public health agencies at the federal, state, and local level are responsible for implementing actions and policies that address health problems related to environmental hazards. These actions and policies can be informed by integrating or linking data on health, exposure, hazards, and population. The mission of the Centers for Disease Control and Prevention's National Environmental Public Health Tracking Program (Tracking Program) is to provide information from a nationwide network of integrated health, environmental hazard, and exposure data that drives actions to improve the health of communities. The Tracking Program and federal, state, and local partners collect, integrate, analyze, and disseminate data and information to inform environmental public health actions. However, many challenges exist regarding the availability and quality of data, the application of appropriate methods and tools to link data, and the state of the science needed to link and analyze health and environmental data. The Tracking Program has collaborated with academia to address key challenges in these areas. The collaboration has improved our understanding of the uses and limitations of available data and methods, expanded the use of existing data and methods, and increased our knowledge about the connections between health and environment. Valuable working relationships have been forged in this process, and together we have identified opportunities and improvements for future collaborations to further advance the science and practice of environmental public health tracking. PMID:25038624

  16. A comparative analysis of the perceived influence of advanced placement and honors programs upon science instruction

    NASA Astrophysics Data System (ADS)

    Herr, Norman Edward

    These are two major models for advanced science instruction in American high schools, the traditional honors program and the Advanced Placement (AP) program of the College Entrance Examination Board. Using the self-reports of teachers who were experienced in teaching honors and AP courses to students of similar academic preparation and ability, the author examined the perceived influences of program format upon the use of basic teaching techniques, the laboratory experience, the pace of the course, curricular freedom, and student creativity. One of the most notable aspects of the AP program is the speed at which teachers move through the curriculum. In the rush to prepare students for the exam, most AP teachers adopt a strong lecture format and minimize student-centered activities such as laboratory experimentation, student projects, and student presentations. When laboratory work is not assessed on the national AP examination, such experiences are sacrificed to provide time for lecture. When laboratory experiments are assessed, however, teachers respond by allocating more time for laboratory work, and by upgrading their exercises to make them more quantitative and experimental than those used previously or those used in honors classes. Although AP is associated with a loss in curricular freedom and flexibility, teachers perceive no clear influence of program format upon student creativity.

  17. The Society for the Advancement of Chicanos and Native Americans in Science (SACNAS) Geoscience Initiative

    NASA Astrophysics Data System (ADS)

    Velasco, A. A.; Lopez, R. E.; Zavala, M.

    2002-12-01

    The Society for the Advancement of Chicanos and Native Americans in Science (SACNAS) focuses on encouraging undergraduate and graduate minority students to pursue higher degrees. For over 29 years, SACNAS has provided strong national leadership in improving science and math education, as well as expanding opportunities for minorities in the scientific workforce and academia. SACNAS' Annual National Conference and Teacher Workshops, summer research opportunities, E-mentoring program, and online internship/job placement resources are tools that help a diverse community of students, professors, administrators, and K-12 educators achieve expertise within their disciplines. The SACNAS Annual National Conference is the centerpiece of our programs. The conferences feature career advancement workshops, scientific symposia, exhibits, student presentations and guest speakers designed to provide the resources Chicano/Latino, Native American, and other postdoctoral, graduate and undergraduate science and engineering students need to pursue a advanced degrees in the sciences. Guest speakers are chosen for their excellence in scientific research and their ability to convey the wonder and importance of science through the presentation of their research results. SACNAS has recently included a geological science emphasis to its existing programs to address the need to diversify the field. This talk will outline our approach, and outline how SACNAS has been able to grow over the past 30 years.

  18. Interactive Higher Education Instruction to Advance STEM Instruction in the Environmental Sciences - the Brownfield Action Model

    NASA Astrophysics Data System (ADS)

    Liddicoat, J. C.; Bower, P.

    2015-12-01

    The U.S. Environmental Protection Agency estimates that presently there are over half a million brownfields in the United States, but this number only includes sites for which an Environmental Site Assessment has been conducted. The actual number of brownfields is certainly in the millions and constitutes one of the major environmental issues confronting all communities today. Taught in part or entirely online for more than 15 years in environmental science, engineering, and hydrology courses at over a dozen colleges, universities, and high schools in the United States, Brownfield Action (BA) is an interactive, web-based simulation that combines scientific expertise, constructivist education philosophy, and multimedia to advance the teaching of environmental science (Bower et al., 2011, 2014; Liddicoat and Bower, 2015). In the online simulation and classroom, students form geotechnical consulting companies with a peer chosen at random to solve a problem in environmental forensics. The BA model contains interdisciplinary scientific and social information that are integrated within a digital learning environment that encourages students to construct their knowledge as they learn by doing. As such, the approach improves the depth and coherence of students understanding of the course material. Like real-world environmental consultants and professionals, students are required to develop and apply expertise from a wide range of fields, including environmental science and engineering as well as journalism, medicine, public health, law, civics, economics, and business management. The overall objective is for students to gain an unprecedented appreciation of the complexity, ambiguity, and risk involved in any environmental issue, and to acquire STEM knowledge that can be used constructively when confronted with such an issue.

  19. Regulatory aspects on nanomedicines.

    PubMed

    Sainz, Vanessa; Conniot, João; Matos, Ana I; Peres, Carina; Zupancic, Eva; Moura, Liane; Silva, Liana C; Florindo, Helena F; Gaspar, Rogério S

    2015-12-18

    Nanomedicines have been in the forefront of pharmaceutical research in the last decades, creating new challenges for research community, industry, and regulators. There is a strong demand for the fast development of scientific and technological tools to address unmet medical needs, thus improving human health care and life quality. Tremendous advances in the biomaterials and nanotechnology fields have prompted their use as promising tools to overcome important drawbacks, mostly associated to the non-specific effects of conventional therapeutic approaches. However, the wide range of application of nanomedicines demands a profound knowledge and characterization of these complex products. Their properties need to be extensively understood to avoid unpredicted effects on patients, such as potential immune reactivity. Research policy and alliances have been bringing together scientists, regulators, industry, and, more frequently in recent years, patient representatives and patient advocacy institutions. In order to successfully enhance the development of new technologies, improved strategies for research-based corporate organizations, more integrated research tools dealing with appropriate translational requirements aiming at clinical development, and proactive regulatory policies are essential in the near future. This review focuses on the most important aspects currently recognized as key factors for the regulation of nanomedicines, discussing the efforts under development by industry and regulatory agencies to promote their translation into the market. Regulatory Science aspects driving a faster and safer development of nanomedicines will be a central issue for the next years. PMID:26260323

  20. Science, politics, and health in the brave new world of pharmaceutical carcinogenic risk assessment: Technical progress or cycle of regulatory capture?

    PubMed Central

    Abraham, John; Ballinger, Rachel

    2012-01-01

    The carcinogenicity (cancer-inducing potential) of pharmaceuticals is an important risk factor for health when considering whether thousands of patients on drug trials or millions/billions of consumers in the marketplace should be exposed to a new drug. Drawing on fieldwork involving over 50 interviews and documentary research spanning 2002–2010 in Europe and the US, and on regulatory capture theory, this article investigates how the techno-regulatory standards for carcinogenicity testing of pharmaceuticals have altered since 1998. It focuses on the replacement of long-term carcinogenicity tests in rodents (especially mice) with shorter-term tests involving genetically-engineered mice (GEM). Based on evidence regarding financial/organizational control, methodological design, and interpretation of the validation and application of these new GEM tests, it is argued that regulatory agencies permitted the drug industry to shape such validation and application in ways that prioritized commercial interests over the need to protect public health. Boundary-work enabling industry scientists to define some standards of public-health policy facilitated such capture. However, as the scientific credibility of GEM tests as tools to protect public health by screening out carcinogens became inescapably problematic, a regulatory resurgence, impelled by reputational concerns, exercised more control over industry’s construction and use of the tests, The extensive problems with GEM tests as public-health protective regulatory science raises the spectre that alterations to pharmaceutical carcinogenicity-testing standards since the 1990s may have been boundary-work in which the political project of decreasing the chance that companies’ products are defined as carcinogenic has masqueraded as techno-science. PMID:22784375

  1. Obstacles in Advancement of Young Female Geoscientists: Research Results from the Earth Science Women's Network (ESWN)

    NASA Astrophysics Data System (ADS)

    Kogan, M.; Laursen, S. L.

    2011-12-01

    While the number of women receiving advanced degrees in the geosciences has been rising, the faces of scientific leaders in academia remain dominantly male. Women are currently underrepresented in tenure-track positions in Earth science departments at research universities. Additionally, women are less likely to have more senior positions within their academic institutions. ESWN is a peer-mentoring network of early career women in the Earth sciences. We conducted a survey of ESWN members as part of an evaluation-with-research study that aims to determine the career needs of young female geoscientists. We also conducted a survey of the co-ed Earth Science Jobs list also run by ESWN and used its male and female members as comparison samples. The survey data provide insight into critical career junctures for women in geosciences and identify salient issues that institutions will need to address to successfully recruit, retain and promote women scientists. Prior research has shown that women are subjected to unintended and unrecognized biases that can have an ultimate impact on their productivity, advancement, and success. Our data corroborate these findings: women consistently rated the professional atmosphere in their departments and their interactions with colleagues less favorably than men. Moreover, women indicated lower rates of collaboration with colleagues in their unit compared to their male peers. Possibly due to this discrepancy in collaboration, women also reported lower research productivity than men in our study. Attaining work/life balance is a particular concern to early-career scientists, especially since tenure clock and the biological clock can coincide and reduce the opportunity for women to achieve tenure and have children. Family issues may impact the success of women in academic careers, such as travel to meetings and field work. Our research shows that women's partners more often worked in STEM fields, potentially complicating women's careers by

  2. Toxicogenomics in regulatory ecotoxicology

    USGS Publications Warehouse

    Ankley, Gerald T.; Daston, George P.; Degitz, Sigmund J.; Denslow, Nancy D.; Hoke, Robert A.; Kennedy, Sean W.; Miracle, Ann L.; Perkins, Edward J.; Snape, Jason; Tillitt, Donald E.; Tyler, Charles R.; Versteeg, Donald

    2006-01-01

    Recently, we have witnessed an explosion of different genomic approaches that, through a combination of advanced biological, instrumental, and bioinformatic techniques, can yield a previously unparalleled amount of data concerning the molecular and biochemical status of organisms. Fueled partially by large, well-publicized efforts such as the Human Genome Project, genomic research has become a rapidly growing topical area in multiple biological disciplines. Since 1999, when the term “toxicogenomics” was coined to describe the application of genomics to toxicology (1), a rapid increase in publications on the topic has occurred (Figure 1). The potential utility of toxicogenomics in toxicological research and regulatory activities has been the subject of scientific discussions and, as with any new technology, has evoked a wide range of opinion (2–6). VIEWPOINT © 2006 american chemical Society july 1, 2006 / EnvironmEntal SciEncE & tEchnology n 4055 The purpose of this feature article is to consider the roles of toxicogenomics in the field of regulatory ecotoxicology, explore current limitations in the science and practice of genomics, and propose possible avenues to approach and resolve some of the major challenges. A significant amount of input to our analysis came from a workshop sponsored by the Society of Environmental Toxicology and Chemistry (SETAC) in Pellston, Mich., in September 2005. A complete list of names and affiliations of the experts participating in that workshop is provided online in Table 1 of the Supporting Information for this paper.

  3. Case studies of community college non-science majors: Effects of self-regulatory interventions on biology self-efficacy and biological literacy

    NASA Astrophysics Data System (ADS)

    Maurer, Matthew J.

    Science literacy has been at the heart of current reform efforts in science education. The focus on developing essential skills needed for individual ability to be literate in science has been at the forefront of most K--12 science curricula. Reform efforts have begun to stretch into the postsecondary arena as well, with an ever increasing dialogue regarding the need for attention to science literacy by college students, especially non-science majors. This study set out to investigate how the use of self-regulatory interventions (specifically, goal setting, concept mapping, and reflective writing) affected student biology self-efficacy and biological literacy. This study employed a qualitative research design, analyzing three case studies. Participants in the study received ten self-regulatory interventions as a set of portfolio assignments. Portfolio work was qualitatively analyzed and coded for self-efficacy, as well as evidence of biological literacy. A biology self-efficacy survey was administered pre- and post- to provide a means of self-efficacy data triangulation. Literacy data was supported via a biological literacy rubric, constructed specifically for this study. Results indicated that mastery experiences were the source of biology self-efficacy. Self-efficacy for specific tasks increased over time, and changes in self-efficacy were corroborated by the self-efficacy survey. Students were found to express biological literacy at nominal, functional, or conceptual levels depending on the specific task. This was supported by data from the biological literacy rubric scores. Final conclusions and implications for the study indicated the need for further research with more samples of students in similar and different contexts. Given the fact that the literature in this area is sparse, the results obtained here have only begun to delve into this area of research. Generalization to other biology courses or contexts outside of the one presented in this study was

  4. Historical geographies of provincial science: themes in the setting and reception of the British Association for the Advancement of Science in Britain and Ireland, 1831-c.1939.

    PubMed

    Withers, Charles; Higgitt, Rebekah; Finnegan, Diarmid

    2008-09-01

    The British Association for the Advancement of Science sought to promote the understanding of science in various ways, principally by having annual meetings in different towns and cities throughout Britain and Ireland (and, from 1884, in Canada, South Africa and Australia). This paper considers how far the location of its meetings in different urban settings influenced the nature and reception of the association's activities in promoting science, from its foundation in 1831 to the later 1930s. Several themes concerning the production and reception of science--promoting, practising, writing and receiving--are examined in different urban contexts. We consider the ways in which towns were promoted as venues for and centres of science. We consider the role of local field sites, leading local practitioners and provincial institutions for science in attracting the association to different urban locations. The paper pays attention to excursions and to the evolution and content of the BAAS meeting handbook as a 'geographical' guide to the significance of the regional setting and to appropriate scientific venues. The paper considers the reception of BAAS meetings and explores how far the association's intentions for the promotion of science varied by location and by section within the BAAS. In examining these themes--the geographical setting of the association's meetings, the reception of association science in local civic and intellectual context and the importance of place to an understanding of what the BAAS did and how it was received--the paper extends existing knowledge of the association and contributes to recent work within the history of science which has emphasized the 'local' nature of science's making and reception and the mobility of scientific knowledge. PMID:19244850

  5. Meats Units for Agricultural Science I and Advanced Livestock Production and Marketing Courses. Instructor's Guide. Volume 18, Number 4.

    ERIC Educational Resources Information Center

    Stewart, Bob R.; McCaskey, Michael J.

    These two units are designed to aid teachers in lesson planning in the secondary agricultural education curriculum in Missouri. The first unit, on meat identification, is to be taught as part of the first year of instruction in agricultural science, while the second unit, advanced meats, was prepared for use with 11th- and 12th-grade students in…

  6. Gender Equity in Science and Engineering: Advancing Change in Higher Education. Routledge Studies in Management, Organizations and Society

    ERIC Educational Resources Information Center

    Bilimoria, Diana; Liang, Xiangfen

    2011-01-01

    Women faculty's participation in academic science and engineering is critical for future US global competitiveness, yet their underrepresentation particularly in senior positions remains a widespread problem. To overcome persistent institutional resistance and barriers to change, the "NSF ADVANCE" institutional transformation initiative,…

  7. Recent advance in Asian polar science - Commemorating ten-year activities of the Asian Forum for Polar Sciences (AFoPS)

    NASA Astrophysics Data System (ADS)

    Watanabe, Kentaro; Doi, Koichiro; Ewe, Hong Tat; Krishnan, Kottekkatu Padinchati; Lee, Jae Il; Liu, Ruiyuan

    2015-12-01

    The Asian Forum for Polar Sciences (AFoPS) was established in 2004 to encourage and facilitate cooperation for the advance of polar sciences among countries in the Asian region. It commemorated tenth anniversary organizing the AFoPS Symposium on 7 October, 2014 in Port Dickson, Malaysia, hosted by the National Antarctic Research Center (NARC), University of Malaya. This second volume of AFoPS Special Issue includes those presentations submitted to the Symposium and scientific papers from AFoPS countries on wide variety of polar research. This publication is one of the excellent achievements of AFoPS.

  8. Advancing the Perceptions of the Nature of Science (NOS): Integrating Teaching the NOS in a Science Content Course

    ERIC Educational Resources Information Center

    Aflalo, Ester

    2014-01-01

    Background: Understanding the nature of science (NOS) has been a key objective in teaching sciences for many years. Despite the importance of this goal it is, until this day, a complex challenge that we are far from achieving. Purpose: The study was conducted in order to further the understanding of the NOS amongst preservice teachers. It explores…

  9. Evaluation of Policy and Research Interventions in Science and Technology: Consequence Assessment of Regulatory and Technology Transfer Programs

    ERIC Educational Resources Information Center

    Dias, Mary Beatrice

    2011-01-01

    This research contributes to efforts in assessment studies related to science and technology interventions. The work presented in this thesis focuses on understanding the effects of policies that influence science and technology interventions, and determining the impact of science and technology interventions themselves. Chapter 1 explores how…

  10. The advanced manufacturing science and technology program. FY 95 Annual Report

    SciTech Connect

    Hill, J.

    1996-03-01

    This is the Fiscal Year 1995 Annual Report for the Advanced Manufacturing Science and Technology (AMST) sector of Los Alamos Tactical Goal 6, Industrial Partnering. During this past fiscal year, the AMST project leader formed a committee whose members represented the divisions and program offices with a manufacturing interest to examine the Laboratory`s expertise and needs in manufacturing. From a list of about two hundred interest areas, the committee selected nineteen of the most pressing needs for weapon manufacturing. Based upon Los Alamos mission requirements and the needs of the weapon manufacturing (Advanced Design and Production Technologies (ADaPT)) program plan and the other tactical goals, the committee selected four of the nineteen areas for strategic planning and possible industrial partnering. The areas selected were Casting Technology, Constitutive Modeling, Non-Destructive Testing and Evaluation, and Polymer Aging and Lifetime Prediction. For each area, the AMST committee formed a team to write a roadmap and serve as a partnering technical consultant. To date, the roadmaps have been completed for each of the four areas. The Casting Technology and Polymer Aging teams are negotiating with specific potential partners now, at the close of the fiscal year. For each focus area we have created a list of existing collaborations and other ongoing partnering activities. In early Fiscal Year 1996, we will continue to develop partnerships in these four areas. Los Alamos National Laboratory instituted the tactical goals for industrial partnering to focus our institutional resources on partnerships that enhance core competencies and capabilities required to meet our national security mission of reducing the nuclear danger. The second industry sector targeted by Tactical Goal 6 was the chemical industry. Tactical Goal 6 is championed by the Industrial Partnership Office.

  11. Recent advances in the dissection of drought-stress regulatory networks and strategies for development of drought-tolerant transgenic rice plants

    PubMed Central

    Todaka, Daisuke; Shinozaki, Kazuo; Yamaguchi-Shinozaki, Kazuko

    2015-01-01

    Advances have been made in the development of drought-tolerant transgenic plants, including cereals. Rice, one of the most important cereals, is considered to be a critical target for improving drought tolerance, as present-day rice cultivation requires large quantities of water and as drought-tolerant rice plants should be able to grow in small amounts of water. Numerous transgenic rice plants showing enhanced drought tolerance have been developed to date. Such genetically engineered plants have generally been developed using genes encoding proteins that control drought regulatory networks. These proteins include transcription factors, protein kinases, receptor-like kinases, enzymes related to osmoprotectant or plant hormone synthesis, and other regulatory or functional proteins. Of the drought-tolerant transgenic rice plants described in this review, approximately one-third show decreased plant height under non-stressed conditions or in response to abscisic acid treatment. In cereal crops, plant height is a very important agronomic trait directly affecting yield, although the improvement of lodging resistance should also be taken into consideration. Understanding the regulatory mechanisms of plant growth reduction under drought stress conditions holds promise for developing transgenic plants that produce high yields under drought stress conditions. Plant growth rates are reduced more rapidly than photosynthetic activity under drought conditions, implying that plants actively reduce growth in response to drought stress. In this review, we summarize studies on molecular regulatory networks involved in response to drought stress. In a separate section, we highlight progress in the development of transgenic drought-tolerant rice plants, with special attention paid to field trial investigations. PMID:25741357

  12. Equal Educational Opportunity and Nondiscrimination for Girls in Advanced Mathematics, Science, and Technology Education: Federal Enforcement of Title IX. Equal Educational Opportunity Project Series, Volume V.

    ERIC Educational Resources Information Center

    Aneckstein, Laura; Baird, Andrea; Butler, Margaret; Chambers, David; Johnson, Wanda; Kraus, Rebecca; Mann, Eric; Trost, Tami; Zalokar, Nadja; Zieseniss, Mireille

    This report focuses on the Office for Civil Rights' (OCR's) activities relating to Title IX and advanced mathematics, science, and technology education for girls. It examines some of the barriers and inequities that undermine girls' opportunities to choose college majors and enter careers in the advanced mathematics, science, and technology…

  13. Using Digital Globes to Explore the Deep Sea and Advance Public Literacy in Earth System Science

    NASA Astrophysics Data System (ADS)

    Beaulieu, S. E.; Brickley, A.; Emery, M.; Spargo, A.; Patterson, K.; Joyce, K.; Silva, T.; Madin, K.

    2014-12-01

    Digital globes are new technologies increasingly used in both informal and formal education to display global datasets. By creating a narrative using multiple datasets, linkages between Earth systems - lithosphere, hydrosphere, atmosphere, and biosphere - can be conveyed. But how effective are digital globes in advancing public literacy in Earth system science? We addressed this question in developing new content for digital globes that interweaves imagery obtained by deep-diving vehicles with global datasets, including a new dataset locating the world's known hydrothermal vents. Our two narratives, "Life Without Sunlight" (LWS) and "Smoke and Fire Underwater" (SFU), each focus on STEM (science, technology, engineering, and mathematics) principles related to geology, biology, and exploration. We are preparing a summative evaluation for our content delivered on NOAA's Science on a Sphere as interactive presentations and as movies. We tested knowledge gained with respect to the STEM principles and the level of excitement generated by the virtual deep-sea exploration. We conducted a Post-test Only Design with quantitative data based on self-reporting on a Likert scale. A total of 75 adults and 48 youths responded to our questionnaire, distributed into test groups that saw either one of the two narratives delivered either as a movie or as an interactive presentation. Here, we report preliminary results for the youths, the majority (81%) of which live in towns with lower income and lower levels of educational attainment as compared to other towns in Massachusetts. For both narratives, there was knowledge gained for all 6 STEM principles and "Quite a Bit" of excitement. The mode in responses for knowledge gained was "Quite a Bit" for both the movie and the interactive presentation for 4 of the STEM principles (LWS geology, LWS biology, SFU geology, and SFU exploration) and "Some" for SFU biology. Only for LWS exploration was there a difference in mode between the

  14. A Hybrid-Cloud Science Data System Enabling Advanced Rapid Imaging & Analysis for Monitoring Hazards

    NASA Astrophysics Data System (ADS)

    Hua, H.; Owen, S. E.; Yun, S.; Lundgren, P.; Moore, A. W.; Fielding, E. J.; Radulescu, C.; Sacco, G.; Stough, T. M.; Mattmann, C. A.; Cervelli, P. F.; Poland, M. P.; Cruz, J.

    2012-12-01

    Volcanic eruptions, landslides, and levee failures are some examples of hazards that can be more accurately forecasted with sufficient monitoring of precursory ground deformation, such as the high-resolution measurements from GPS and InSAR. In addition, coherence and reflectivity change maps can be used to detect surface change due to lava flows, mudslides, tornadoes, floods, and other natural and man-made disasters. However, it is difficult for many volcano observatories and other monitoring agencies to process GPS and InSAR products in an automated scenario needed for continual monitoring of events. Additionally, numerous interoperability barriers exist in multi-sensor observation data access, preparation, and fusion to create actionable products. Combining high spatial resolution InSAR products with high temporal resolution GPS products--and automating this data preparation & processing across global-scale areas of interests--present an untapped science and monitoring opportunity. The global coverage offered by satellite-based SAR observations, and the rapidly expanding GPS networks, can provide orders of magnitude more data on these hazardous events if we have a data system that can efficiently and effectively analyze the voluminous raw data, and provide users the tools to access data from their regions of interest. Currently, combined GPS & InSAR time series are primarily generated for specific research applications, and are not implemented to run on large-scale continuous data sets and delivered to decision-making communities. We are developing an advanced service-oriented architecture for hazard monitoring leveraging NASA-funded algorithms and data management to enable both science and decision-making communities to monitor areas of interests via seamless data preparation, processing, and distribution. Our objectives: * Enable high-volume and low-latency automatic generation of NASA Solid Earth science data products (InSAR and GPS) to support hazards

  15. Advancing the 3Rs in regulatory toxicology - Carcinogenicity testing: Scope for harmonisation and advancing the 3Rs in regulated sectors of the European Union.

    PubMed

    Annys, Erwin; Billington, Richard; Clayton, Rick; Bremm, Klaus-Dieter; Graziano, Michael; McKelvie, Jo; Ragan, Ian; Schwarz, Michael; van der Laan, Jan Willem; Wood, Charles; Öberg, Mattias; Wester, Piet; Woodward, Kevin N

    2014-07-01

    Different government agencies operating in the European Union regulate different types of chemical products but all require testing for carcinogenicity to support applications for product marketing and commercialisation. A conference was held in Brussels in 2013 where representatives of the pharmaceutical, animal health, chemical and plant protection industries, together with representatives of regulatory agencies, universities and other stakeholders, met under the auspices of The European Partnership for Alternative Approaches to Animal Testing (EPAA) to discuss the varying requirements for carcinogenicity testing, and how these studies might be refined to improve hazard evaluation and risk assessment while implementing principles of the 3Rs (replacement, refinement and reduction in animal studies). While there are some similarities, the regulatory approaches in pharmaceutical, animal health, chemical and plant protection sectors have varying degrees of flexibility in requirements for carcinogenicity testing, to an extent reflecting concerns over the magnitude and duration of human exposure, either directly as in therapeutic exposure to pharmaceuticals, or indirectly through the ingestion of residues of veterinary drugs or plant protection chemicals. The article discusses these differences and other considerations for modified carcinogenicity testing paradigms on the basis of scientific and 3Rs approaches. PMID:24768934

  16. Unexpected Allies: Advancing Literacy in a "Science-English" Cross-Curricular Context

    ERIC Educational Resources Information Center

    McClune, Billy; Alexander, Joy; Jarman, Ruth

    2012-01-01

    Critical reading of science-based media reports is an authentic context in which to explore the mutual interests of teachers of science and English, who want to use science in the media to promote their subject discipline while encouraging cross-curricular learning. This empirical study focused on 90 teachers of science and English to explore…

  17. Realizing the potential of the CUAHSI Water Data Center to advance Earth Science

    NASA Astrophysics Data System (ADS)

    Hooper, R. P.; Seul, M.; Pollak, J.; Couch, A.

    2015-12-01

    The CUAHSI Water Data Center has developed a cloud-based system for data publication, discovery and access. Key features of this system are a semantically enabled catalog to discover data across more than 100 different services and delivery of data and metadata in a standard format. While this represents a significant technical achievement, the purpose of this system is to support data reanalysis for advancing science. A new web-based client, HydroClient, improves access to the data from previous clients. This client is envisioned as the first step in a workflow that can involve visualization and analysis using web-processing services, followed by download to local computers for further analysis. The release of the WaterML library in the R package CRAN repository is an initial attempt at linking the WDC services in a larger analysis workflow. We are seeking community input on other resources required to make the WDC services more valuable in scientific research and education.

  18. Advanced Tissue Sciences Inc.: learning from the past, a case study for regenerative medicine.

    PubMed

    Pangarkar, Nitin; Pharoah, Marc; Nigam, Avinav; Hutmacher, Dietmar W; Champ, Simon

    2010-09-01

    On 31st March 2003 Advanced Tissue Sciences (ATS) was liquidated, with the effect that in excess of US$300 million of stakeholder financing was destroyed. Although successful in the development of breakthrough technologies in the regenerative medicine arena and the building of a substantial portfolio of patents, the company never made a profit. In this case study, ATS’ business strategy, market and competitive environment will be discussed in the context of the company’s historical development. A number of important lessons from this case are discussed. From a management perspective the most critical lesson is the importance of effective financial planning and management of costs, and in particular R&D costs, including the significant costs associated with clinical trials. In addition, a clear strategic focus is extremely important due to the significant resources required in the development of a new therapy. From an investor’s perspective the lessons to be gathered from the ATS case are related to the risk involved in investing in the field of regenerative medicine. This case indicates that both professional and private investors did not fully question the validity of ATS’ business strategy and financial forecasts. A clear and focused strategy based on long-term investor commitment is essential for the successful commercialization of regenerative medicine. PMID:20868336

  19. Regulatory acceptance of animal models of disease to support clinical trials of medicines and advanced therapy medicinal products.

    PubMed

    Cavagnaro, Joy; Silva Lima, Beatriz

    2015-07-15

    The utility of animal models of disease for assessing the safety of novel therapeutic modalities has become an increasingly important topic of discussion as research and development efforts focus on improving the predictive value of animal studies to support accelerated clinical development. Medicines are approved for marketing based upon a determination that their benefits outweigh foreseeable risks in specific indications, specific populations, and at specific dosages and regimens. No medicine is 100% safe. A medicine is less safe if the actual risks are greater than the predicted risks. The purpose of preclinical safety assessment is to understand the potential risks to aid clinical decision-making. Ideally preclinical studies should identify potential adverse effects and design clinical studies that will minimize their occurrence. Most regulatory documents delineate the utilization of conventional "normal" animal species to evaluate the safety risk of new medicines (i.e., new chemical entities and new biological entities). Animal models of human disease are commonly utilized to gain insight into the pathogenesis of disease and to evaluate efficacy but less frequently utilized in preclinical safety assessment. An understanding of the limitations of the animal disease models together with a better understanding of the disease and how toxicity may be impacted by the disease condition should allow for a better prediction of risk in the intended patient population. Importantly, regulatory authorities are becoming more willing to accept and even recommend data from experimental animal disease models that combine efficacy and safety to support clinical development. PMID:25814257

  20. 77 FR 52977 - Regulatory Capital Rules: Advanced Approaches Risk-Based Capital Rule; Market Risk Capital Rule

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-30

    ...The Office of the Comptroller of the Currency (OCC), the Board of Governors of the Federal Reserve System (Board), and the Federal Deposit Insurance Corporation (FDIC) (collectively, the agencies) are seeking comment on three notices of proposed rulemaking (NPRs) that would revise and replace the agencies' current capital rules. In this NPR (Advanced Approaches and Market Risk NPR) the......

  1. Advances in materials science, Metals and Ceramics Division. Triannual progress report, February-May 1980

    SciTech Connect

    Truhan, J.J.; Gordon, K.M.

    1980-08-01

    Research is reported in the magnetic fusion energy and laser fusion energy programs, aluminium-air battery and vehicle research, geothermal research, nuclear waste management, basic energy science, and chemistry and materials science. (FS)

  2. Advances in materials science, metals and ceramics division. Triannual progress report, June-September 1980

    SciTech Connect

    Truhan, J.J.; Hopper, R.W.; Gordon, K.M.

    1980-10-28

    Information is presented concerning the magnetic fusion energy program; the laser fusion energy program; geothermal research; nuclear waste management; Office of Basic Energy Sciences (OBES) research; diffusion in silicate minerals; chemistry research resources; and chemistry and materials science research.

  3. Perspective on Advancing FDA Regulatory Monitoring for Mycotoxins in Foods using Liquid Chromatography and Mass Spectrometry (Review).

    PubMed

    Zhang, Kai; Wong, Jon W; Krynitsky, Alexander J; Trucksess, Mary W

    2016-07-01

    The presence of mycotoxins (such as aflatoxins, deoxynivalenol, fumonisins, and patulin) is routinely monitored by the U.S. Food and Drug Administration (FDA) to ensure that their concentrations in food are below the levels requiring regulatory action or advisories. To improve the efficiency of mycotoxin analysis, the researchers at the FDA's Center for Food Safety and Applied Nutrition have been evaluating modern LC-MS technologies. Consequently, a variety of LC-tandem MS and LC-high-resolution MS methods have been developed, which simultaneously identify and quantitate multiple mycotoxins in foods and feeds. Although matrix effects (matrix-induced ion suppression or enhancement) associated with LC-MS-based mycotoxin analysis remain, this review discusses methods for managing these effects and proposes practical solutions for the future implementation of LC-MS-based multimycotoxin analysis. PMID:27330044

  4. Final Project Report "Advanced Concept Exploration For Fast Ignition Science Program"

    SciTech Connect

    STEPHENS, Richard B.; McLEAN, Harry M.; THEOBALD, Wolfgang; AKLI, Kramer; BEG, Farhat N.; SENTOKU, Yasuiko; SCHUMACHER, Douglas; WEI, Mingsheng S.

    2014-01-31

    The Fast Ignition (FI) Concept for Inertial Confinement Fusion has the potential to provide a significant advance in the technical attractiveness of Inertial Fusion Energy (IFE) reactors. FI differs from conventional “central hot spot” (CHS) target ignition by decoupling compression from heating: using the laser (or heavy ion beam or Z pinch) drive pulse (10’s of ns) to create a dense fuel and a second, much shorter (~10 ps) high intensity pulse to ignite a small region of it. There are two major physics issues concerning this concept; controlling the laser-induced generation of large electron currents and their propagation through high density plasmas. This project has addressed these two significant scientific issues in Relativistic High Energy Density (RHED) physics. Learning to control relativistic laser matter interaction (and the limits and potential thereof) will enable a wide range of applications. While these physics issues are of specific interest to inertial fusion energy science, they are also important for a wide range of other HED phenomena, including high energy ion beam generation, isochoric heating of materials, and the development of high brightness x-ray sources. Generating, controlling, and understanding the extreme conditions needed to advance this science has proved to be challenging: Our studies have pushed the boundaries of physics understanding and are at the very limits of experimental, diagnostic, and simulation capabilities in high energy density laboratory physics (HEDLP). Our research strategy has been based on pursuing the fundamental physics underlying the Fast Ignition (FI) concept. We have performed comprehensive study of electron generation and transport in fast-ignition targets with experiments, theory, and numerical modeling. A major issue is that the electrons produced in these experiments cannot be measured directly—only effects due to their transport. We focused mainly on x-ray continuum photons from bremsstrahlung

  5. Development of 3D multimedia with advanced computer animation tools for outreach activities related to Meteor Science and Meteoritics

    NASA Astrophysics Data System (ADS)

    Madiedo, J. M.

    2012-09-01

    Documentaries related to Astronomy and Planetary Sciences are a common and very attractive way to promote the interest of the public in these areas. These educational tools can get benefit from new advanced computer animation software and 3D technologies, as these allow making these documentaries even more attractive. However, special care must be taken in order to guarantee that the information contained in them is serious and objective. In this sense, an additional value is given when the footage is produced by the own researchers. With this aim, a new documentary produced and directed by Prof. Madiedo has been developed. The documentary, which has been entirely developed by means of advanced computer animation tools, is dedicated to several aspects of Meteor Science and Meteoritics. The main features of this outreach and education initiative are exposed here.

  6. Advancing the science of measurement of diagnostic errors in healthcare: the Safer Dx framework

    PubMed Central

    Singh, Hardeep; Sittig, Dean F

    2015-01-01

    Diagnostic errors are major contributors to harmful patient outcomes, yet they remain a relatively understudied and unmeasured area of patient safety. Although they are estimated to affect about 12 million Americans each year in ambulatory care settings alone, both the conceptual and pragmatic scientific foundation for their measurement is under-developed. Health care organizations do not have the tools and strategies to measure diagnostic safety and most have not integrated diagnostic error into their existing patient safety programs. Further progress toward reducing diagnostic errors will hinge on our ability to overcome measurement-related challenges. In order to lay a robust groundwork for measurement and monitoring techniques to ensure diagnostic safety, we recently developed a multifaceted framework to advance the science of measuring diagnostic errors (The Safer Dx framework). In this paper, we describe how the framework serves as a conceptual foundation for system-wide safety measurement, monitoring and improvement of diagnostic error. The framework accounts for the complex adaptive sociotechnical system in which diagnosis takes place (the structure), the distributed process dimensions in which diagnoses evolve beyond the doctor's visit (the process) and the outcomes of a correct and timely “safe diagnosis” as well as patient and health care outcomes (the outcomes). We posit that the Safer Dx framework can be used by a variety of stakeholders including researchers, clinicians, health care organizations and policymakers, to stimulate both retrospective and more proactive measurement of diagnostic errors. The feedback and learning that would result will help develop subsequent interventions that lead to safer diagnosis, improved value of health care delivery and improved patient outcomes. PMID:25589094

  7. A Rooftop Radio Observatory: A New Method for Teaching Science Fundamentals to Advanced Undergraduates

    NASA Astrophysics Data System (ADS)

    Frank, C.; Cudaback, D.; Heiles, C.; Treffers, R.; Hancox, C.; Millan, R.; Parthasarathy, R.

    1996-05-01

    This paper reports on an innovative teaching style for the instruction of advanced undergraduates in experimental science fundamentals. Working under the belief that a complete education includes both theoretical work and ``hands-on'' laboratory experience, a radio observatory has been created on top of the U. C. Berkeley Astronomy Department building. Class work with this observatory give students an understanding of: (1) components of a radio telescope system, (2) system operation and trouble-shooting, (3) observation strategies, (4) data collection and reduction, and (5) presentation and visualization of results. Our antenna consists of a two meter tall pyramidal horn optimized to observe the 21 cm atomic hydrogen transition. The receiver consists of a double-heterodyning system with a PC to sample and Fourier transform the signal and generate a power spectrum. System components were constructed by students with guidance from faculty members. Students using this system obtain power spectra representing the Doppler shifted HI line, as a function of galactic coordinate. Students derive results including basic galactic structure and rotation and mass curves. Further technical information is presented in the accompanying poster paper. Close contact between students and equipment is essential for successful comprehension of fundamental concepts. The system is constructed such that most components can be individually examined or assembled on a bench-top in a configuration the student wishes to explore. We believe that systems which perform real astronomy can be duplicated by other universities. The small scale of the antenna as well as the strength of the HI line require a small allocation of resources to implement an observation system. The ``hands-on'' approach compliments theoretical course work, in addition to providing practical experience for students who may not be inclined towards graduate school. Finally, this educational technique is exportable and

  8. Use of social science-based analysis in bureaucratic decision making: regulatory analysis in the Environmental Protection Agency

    SciTech Connect

    Mogee, M.E.

    1983-01-01

    This dissertation studies the use of regulatory analysis (a form of cost-benefit analysis) in Environmental Protection Agency (EPA) decision making. It addresses the questions of how the analysis was used, what influence it had on the regulations, and what the major factors were that affected its use. Case studies were conducted of six EPA rule makings during the period 1978 to 1980, including: Premanufacture Notification under TSCA Section 5; the Carbon Monoxide National Ambient Air Quality Standard; Visibility Protection; Light-Duty Truck gaseous emissions; effluent guidelines for Timber Products industries; and Motorcycle Noise standards. Data for the cases came from official documents and interviews with EPA participants. Regulatory analysis was used in EPA regulation development in six ways: in decision making, to support or legitimate, in intra-agency partisan negotiations, to review or exercise quality control, to describe or educate, and in external relations. The influence of the analysis on the regulations in these cases varied from almost none to moderately high. Even in those cases where the analysis was used in decision making and had relatively high influence, however, it was only one of many factors affecting the regulation. The major factors found to affect the use of regulatory analysis, in addition to the overall context set by EPA's regulation development process, were: the statute; program considerations; the existence of a tradition of economic analysis; the structure and quality of the analysis itself; the timing of the analysis with respect to the rule making; and scientific, technical, and implementation uncertainties.

  9. Effect of the science teaching advancement through modeling physical science professional development workshop on teachers' attitudes, beliefs and content knowledge and students' content knowledge

    NASA Astrophysics Data System (ADS)

    Dietz, Laura

    The Science Teaching Advancement through Modeling Physical Science (STAMPS) professional development workshop was evaluated for effectiveness in improving teachers' and students' content knowledge. Previous research has shown modeling to be an effective method of instruction for improving student and teacher content knowledge, evidenced by assessment scores. Data includes teacher scores on the Force Concept Inventory (FCI; Hestenes, Wells, & Swackhamer, 1992) and the Chemistry Concept Inventory (CCI; Jenkins, Birk, Bauer, Krause, & Pavelich, 2004), as well as student scores on a physics and chemistry assessment. Quantitative data is supported by teacher responses to a post workshop survey and classroom observations. Evaluation of the data shows that the STAMPS professional development workshop was successful in improving both student and teacher content knowledge. Conclusions and suggestions for future study are also included.

  10. Motivation, Achievement, and Advanced Placement Intent of High School Students Learning Science

    ERIC Educational Resources Information Center

    Bryan, Robert R.; Glynn, Shawn M.; Kittleson, Julie M.

    2011-01-01

    Within the framework of social cognitive theory, we examined the motivation of students (14-16 years old) to learn science in their introductory science courses. The students responded to a questionnaire about their intrinsic motivation, self-efficacy, and self-determination. The students also wrote essays about their motivation, and individual…

  11. Seven Actionable Strategies for Advancing Women in Science, Engineering, and Medicine

    PubMed Central

    Smith, Kristin A.; Arlotta, Paola; Watt, Fiona M.; Solomon, Susan L.

    2015-01-01

    Achieving gender equality in science will require devising and implementing strategies to overcome the political, administrative, financial, and cultural challenges that exist in the current environment. In this forum, we propose an initial shortlist of recommendations to promote gender equality in science and stimulate future efforts to level the field. PMID:25748929

  12. CURRICULUM GUIDES IN BIOLOGY--LIFE SCIENCE, BIOLOGY--GENERAL, AND BIOLOGY--ADVANCED PLACEMENT.

    ERIC Educational Resources Information Center

    WESNER, GORDON E.; AND OTHERS

    "BIOLOGY--LIFE SCIENCE" IS GEARED TO STUDENTS OF AVERAGE ABILITY, "BIOLOGY--GENERAL" IS OFFERED FOR THOSE WHO HAVE COMPLETED "BIOLOGY--GENERAL" IN GRADES 10 OR 11 AND WHO WISH TO PURSUE COLLEGE LEVEL STUDY WHILE IN GRADE 12. THE NONTECHNICAL "BIOLOGY--LIFE SCIENCE" HAS OUTLINED UNITS IN ORGANIZING FOOD, ORGAN SYSTEMS, HEALTH, CONTINUANCE OF LIFE,…

  13. Technology to Advance High School and Undergraduate Students with Disabilities in Science, Technology, Engineering, and Mathematics

    ERIC Educational Resources Information Center

    Leddy, Mark H.

    2010-01-01

    Americans with disabilities are underemployed in science, technology, engineering and mathematics (STEM) at higher rates than their nondisabled peers. This article provides an overview of the National science Foundation's Research in Disabilities Education (RDE) program, of technology use by students with disabilities (SWD) in STEM, and of…

  14. The Possibilities and Limits of the Structure-Agency Dialectic in Advancing Science for All

    ERIC Educational Resources Information Center

    Gutiérrez, Kris D.; Calabrese Barton, Angela

    2015-01-01

    In this special issue, the structure-agency dialectic is used to shift the analytic frame in science education from focusing on youth as in need of remediation to rethinking new arrangements, tools, and forms of assistance and participation in support of youth learning science. This shift from "fixing" the individual to re-mediating and…

  15. The NASA Solar System Exploration Virtual Institute: International Efforts in Advancing Lunar Science with Prospects for the Future

    NASA Technical Reports Server (NTRS)

    Schmidt, Gregory K.

    2014-01-01

    The NASA Solar System Exploration Research Virtual Institute (SSERVI), originally chartered in 2008 as the NASA Lunar Science Institute (NLSI), is chartered to advance both the scientific goals needed to enable human space exploration, as well as the science enabled by such exploration. NLSI and SSERVI have in succession been "institutes without walls," fostering collaboration between domestic teams (7 teams for NLSI, 9 for SSERVI) as well as between these teams and the institutes' international partners, resulting in a greater global endeavor. SSERVI teams and international partners participate in sharing ideas, information, and data arising from their respective research efforts, and contribute to the training of young scientists and bringing the scientific results and excitement of exploration to the public. The domestic teams also respond to NASA's strategic needs, providing community-based responses to NASA needs in partnership with NASA's Analysis Groups. Through the many partnerships enabled by NLSI and SSERVI, scientific results have well exceeded initial projections based on the original PI proposals, proving the validity of the virtual institute model. NLSI and SSERVI have endeavored to represent not just the selected and funded domestic teams, but rather the entire relevant scientific community; this has been done through many means such as the annual Lunar Science Forum (now re-named Exploration Science Forum), community-based grass roots Focus Groups on a wide range of topics, and groups chartered to further the careers of young scientists. Additionally, NLSI and SSERVI have co-founded international efforts such as the pan-European lunar science consortium, with an overall goal of raising the tide of lunar science (and now more broadly exploration science) across the world.

  16. The NASA Solar System Exploration Virtual Institute: International Efforts in Advancing Lunar Science with Prospects for the Future

    NASA Astrophysics Data System (ADS)

    Schmidt, Gregory

    The NASA Solar System Exploration Research Virtual Institute (SSERVI), originally chartered in 2008 as the NASA Lunar Science Institute (NLSI), is chartered to advance both the scientific goals needed to enable human space exploration, as well as the science enabled by such exploration. NLSI and SSERVI have in succession been “institutes without walls,” fostering collaboration between domestic teams (7 teams for NLSI, 9 for SSERVI) as well as between these teams and the institutes’ international partners, resulting in a greater global endeavor. SSERVI teams and international partners participate in sharing ideas, information, and data arising from their respective research efforts, and contribute to the training of young scientists and bringing the scientific results and excitement of exploration to the public. The domestic teams also respond to NASA’s strategic needs, providing community-based responses to NASA needs in partnership with NASA’s Analysis Groups. Through the many partnerships enabled by NLSI and SSERVI, scientific results have well exceeded initial projections based on the original PI proposals, proving the validity of the virtual institute model. NLSI and SSERVI have endeavored to represent not just the selected and funded domestic teams, but rather the entire relevant scientific community; this has been done through many means such as the annual Lunar Science Forum (now re-named Exploration Science Forum), community-based grass roots Focus Groups on a wide range of topics, and groups chartered to further the careers of young scientists. Additionally, NLSI and SSERVI have co-founded international efforts such as the pan-European lunar science consortium, with an overall goal of raising the tide of lunar science (and now more broadly exploration science) across the world.

  17. Commnity Petascale Project for Accelerator Science and Simulation: Advancing Computational Science for Future Accelerators and Accelerator Technologies

    SciTech Connect

    Spentzouris, Panagiotis; Cary, John; Mcinnes, Lois Curfman; Mori, Warren; Ng, Cho; Ng, Esmond; Ryne, Robert; /LBL, Berkeley

    2008-07-01

    The design and performance optimization of particle accelerators is essential for the success of the DOE scientific program in the next decade. Particle accelerators are very complex systems whose accurate description involves a large number of degrees of freedom and requires the inclusion of many physics processes. Building on the success of the SciDAC1 Accelerator Science and Technology project, the SciDAC2 Community Petascale Project for Accelerator Science and Simulation (ComPASS) is developing a comprehensive set of interoperable components for beam dynamics, electromagnetics, electron cooling, and laser/plasma acceleration modeling. ComPASS is providing accelerator scientists the tools required to enable the necessary accelerator simulation paradigm shift from high-fidelity single physics process modeling (covered under SciDAC1) to high-fidelity multi-physics modeling. Our computational frameworks have been used to model the behavior of a large number of accelerators and accelerator R&D experiments, assisting both their design and performance optimization. As parallel computational applications, the ComPASS codes have been shown to make effective use of thousands of processors.

  18. Community petascale project for accelerator science and simulation : Advancing computational science for future accelerators and accelerator technologies.

    SciTech Connect

    Spentzouris, P.; Cary, J.; McInnes, L. C.; Mori, W.; Ng, C.; Ng, E.; Ryne, R.

    2008-01-01

    The design and performance optimization of particle accelerators are essential for the success of the DOE scientific program in the next decade. Particle accelerators are very complex systems whose accurate description involves a large number of degrees of freedom and requires the inclusion of many physics processes. Building on the success of the SciDAC-1 Accelerator Science and Technology project, the SciDAC-2 Community Petascale Project for Accelerator Science and Simulation (ComPASS) is developing a comprehensive set of interoperable components for beam dynamics, electromagnetics, electron cooling, and laser/plasma acceleration modelling. ComPASS is providing accelerator scientists the tools required to enable the necessary accelerator simulation paradigm shift from high-fidelity single physics process modeling (covered under SciDAC1) to high-fidelity multiphysics modeling. Our computational frameworks have been used to model the behavior of a large number of accelerators and accelerator R & D experiments, assisting both their design and performance optimization. As parallel computational applications, the ComPASS codes have been shown to make effective use of thousands of processors.

  19. Commnity Petascale Project for Accelerator Science And Simulation: Advancing Computational Science for Future Accelerators And Accelerator Technologies

    SciTech Connect

    Spentzouris, Panagiotis; Cary, John; Mcinnes, Lois Curfman; Mori, Warren; Ng, Cho; Ng, Esmond; Ryne, Robert; /LBL, Berkeley

    2011-10-21

    The design and performance optimization of particle accelerators are essential for the success of the DOE scientific program in the next decade. Particle accelerators are very complex systems whose accurate description involves a large number of degrees of freedom and requires the inclusion of many physics processes. Building on the success of the SciDAC-1 Accelerator Science and Technology project, the SciDAC-2 Community Petascale Project for Accelerator Science and Simulation (ComPASS) is developing a comprehensive set of interoperable components for beam dynamics, electromagnetics, electron cooling, and laser/plasma acceleration modelling. ComPASS is providing accelerator scientists the tools required to enable the necessary accelerator simulation paradigm shift from high-fidelity single physics process modeling (covered under SciDAC1) to high-fidelity multiphysics modeling. Our computational frameworks have been used to model the behavior of a large number of accelerators and accelerator R&D experiments, assisting both their design and performance optimization. As parallel computational applications, the ComPASS codes have been shown to make effective use of thousands of processors.

  20. Characteristics of Advanced Placement environmental science reading teacher participants and their perceptions of the reading as a professional development experience

    NASA Astrophysics Data System (ADS)

    Crawford, Freda M.

    Sixty percent of American high schools offer one or more Advanced Placement courses, and several thousand Advanced Placement teachers serve as Readers or graders of Advanced Placement exams each year. This study was conducted to determine the characteristics of teachers who choose to participate in Advanced Placement Environmental Science Readings and determine how these teachers view the Reading experience as a form of professional development. This study was conducted with teacher participants at the June 2004 Advanced Placement Environmental Science Reading. Sixty of the 114 teacher participants completed a survey regarding their education background, age, experience level, educational philosophy, involvement in professional development opportunities, perceptions of the professional benefits of the Reading, and the influence of the Reading experience on their pedagogical practices. Semi-structured interviews were then conducted with a subset of 18 teacher participants to determine their perceptions regarding the professional benefits of the Reading experience, its potential to serve as a professional development activity, and perceived changes in their pedagogical practices resulting from participation in the Reading process. Results indicate that APES Reading teacher participants are experienced, effective teachers from many parts of the country. These teachers participate in ongoing professional development activities, can delineate components of effective professional development, strongly believe that effective professional development occurs at the APES Reading, and report that their pedagogical practice has improved as a result of participation in the APES Reading. Considering the crucial role teachers play in the educational process, it is important to pursue this additional avenue of professional development in order to further improve APES teacher effectiveness.

  1. The Use of Visual Advance Organizers for Learning Earth Science Concepts.

    ERIC Educational Resources Information Center

    Weisberg, Joseph S.

    This study was designed to determine whether advance organizers in the form of visual aids might serve the same function as Ausubel's verbal advance organizers. The basic design of the study consisted of a 4 X 3 X 2 ANOVA factorial design. Ninety-six eighth-grade students were involved in the study. One group was exposed to a physiographic diagram…

  2. Science Investigations with Laser Ranging to the Moon and Mars/Phobos: Recent Advances, Technology Demonstrations, and New Ideas

    NASA Astrophysics Data System (ADS)

    Turyshev, Slava G.; Williams, James G.; Folkner, William M.

    2010-05-01

    Since it's initiation by the Apollo 11 astronauts in 1969, LLR has strongly contributed to our understanding of the Moon's internal structure and the dynamics of the Earth-Moon system. The data provide for unique, multi-disciplinary results in the areas of lunar science, gravitational physics, Earth sciences, geodesy and geodynamics, solar system ephemerides, and terrestrial and celestial reference frames. However, the current distribution of the retroreflectors is not optimal, other weaknesses exist. A geographic distribution of new instruments on the lunar surface wider than the current distribution would be a great benefit; the accuracy of the lunar science parameters would increase several times. We are developing the next-generation of the LLR experiment. This work includes development of new retroreflector arrays and laser transponders to be deployed on the lunar surface by a series of proposed missions to the moon. The new laser instruments will enable strong advancements in LLR-derived science. Anticipated science impact includes lunar science, gravitational physics, geophysics, and geodesy. Thus, properties of the lunar interior, including tidal properties, liquid core and solid inner core can be determined from lunar rotation, orientation, and tidal response. Anticipated improvements in Earth geophysics and geodesy would include the positions and rates for the Earth stations, Earth rotation, precession rate, nutation, and tidal influences on the orbit. Strong improvements are also expected in several tests of general relativity. We address the science return enabled by the new laser retroreflectors. We also discuss deployment of pulsed laser transponders with future landers on Mars/Phobos. The development of active laser techniques would extend the accuracies characteristic of passive laser tracking to interplanetary distances. Highly-accurate time-series of the round-trip travel times of laser pulses between an observatory on the Earth and an optical

  3. T Regulatory Type 1 Cells in Squamous Cell Carcinoma of the Head and Neck: Mechanisms of Suppression and Expansion in Advanced Disease

    PubMed Central

    Bergmann, Christoph; Strauss, Laura; Wang, Yun; Szczepanski, Miroslaw J.; Lang, Stephan; Johnson, Jonas T.; Whiteside, Theresa L.

    2013-01-01

    Purpose Regulatory T cells play a major role in tumor escape from immunosurveillance. T regulatory cells type 1 (Tr1), a subset of regulatory T cells present in the tumor and peripheral circulation of patients with head and neck squamous cell carcinoma (HNSCC), mediate immune suppression and might contribute to tumor progression. Experimental Design CD4+CD25− T cells were isolated from peripheral blood mononuclear cells (PBMC) or tumor-infiltrating lymphocytes (TIL) of 26 HNSCC patients and 10 normal controls. The Tr1 cell phenotype was determined before and after culture in the presence of interleukin (IL)-2, IL-10, and IL-15, each at 10 to 20 IU/mL. Suppression was measured in carboxyfluorescein diacetate succinimidyl ester – based proliferation assays with or without neutralizing anti-IL-10 or anti – transforming growth factor-β1 (TGF-β1) monoclonal antibodies in Transwell systems. ELISA was used to define the Tr1 cytokine profile. Results Tr1 cells originate from CD4+CD25− precursors present in TIL and PBMC of HNSCC patients. Cytokine-driven ex vivo expansion of Tr1 precursors yielded CD4+CD25−Foxp3lowCD132+IL-10+TGF-β1 + populations that mediated higher suppression than Tr1 cells of normal controls (P < 0.0001). Tr1 cells suppressed proliferation of autologous responders via IL-10 and TGF-β1 secretion. Expression of these cytokines was higher in TIL-derived than PBMC-derived Tr1 cells (P < 0.0001). The Tr1 cell frequency and suppressor function were significantly higher in patients presenting with advanced than early disease stages and in patients “cured” by oncologic therapies than in those with active disease. Conclusions In HNSCC, Tr1 cell generation is promoted at the tumor site. Tr1 cells use TGF-β and IL-10 to mediate suppression. They expand during disease progression and also following cancer therapy in patients with no evident disease. PMID:18559587

  4. A 10-Year Review of the Food Science Summer Scholars Program: A Model for Research Training and for Recruiting Undergraduate Students into Graduate Programs and Careers in Food Science

    ERIC Educational Resources Information Center

    Roberts, Angela J.; Robbins, Janette; McLandsborough, Lynne; Wiedmann, Martin

    2010-01-01

    A pressing problem facing regulatory agencies, academia, and the food industry is a shortage of qualified food science graduates, particularly those with advanced degrees (that is, M.S. or Ph.D.). In 2000, the Cornell Institute of Food Science established the annual Food Science Summer Scholars Program as an experiential summer research program…

  5. Advancing Space Sciences through Undergraduate Research Experiences at UC Berkeley's Space Sciences Laboratory - a novel approach to undergraduate internships for first generation community college students

    NASA Astrophysics Data System (ADS)

    Raftery, C. L.; Davis, H. B.; Peticolas, L. M.; Paglierani, R.

    2015-12-01

    The Space Sciences Laboratory at UC Berkeley launched an NSF-funded Research Experience for Undergraduates (REU) program in the summer of 2015. The "Advancing Space Sciences through Undergraduate Research Experiences" (ASSURE) program recruited heavily from local community colleges and universities, and provided a multi-tiered mentorship program for students in the fields of space science and engineering. The program was focussed on providing a supportive environment for 2nd and 3rd year undergraduates, many of whom were first generation and underrepresented students. This model provides three levels of mentorship support for the participating interns: 1) the primary research advisor provides academic and professional support. 2) The program coordinator, who meets with the interns multiple times per week, provides personal support and helps the interns to assimilate into the highly competitive environment of the research laboratory. 3) Returning undergraduate interns provided peer support and guidance to the new cohort of students. The impacts of this program on the first generation students and the research mentors, as well as the lessons learned will be discussed.

  6. The Food and Drug Administration Office of Women's Health: Impact of Science on Regulatory Policy: An Update.

    PubMed

    Elahi, Merina; Eshera, Noha; Bambata, Nkosazana; Barr, Helen; Lyn-Cook, Beverly; Beitz, Julie; Rios, Maria; Taylor, Deborah R; Lightfoote, Marilyn; Hanafi, Nada; DeJager, Lowri; Wiesenfeld, Paddy; Scott, Pamela E; Fadiran, Emmanuel O; Henderson, Marsha B

    2016-03-01

    The U.S. Food and Drug Administration Office of Women's Health (FDA OWH) has supported women's health research for ∼20 years, funding more than 300 studies on women's health issues, including research on diseases/conditions that disproportionately affect women in addition to the evaluation of sex differences in the performance of and response to medical products. These important women's health issues are studied from a regulatory perspective, with a focus on improving and optimizing medical product development and the evaluation of product safety and efficacy in women. These findings have influenced industry direction, labeling, product discontinuation, safety notices, and clinical practice. In addition, OWH-funded research has addressed gaps in the knowledge about diseases and medical conditions that impact women across the life span such as cardiovascular disease, pregnancy, menopause, osteoporosis, and the safe use of numerous medical products. PMID:26871618

  7. The Food and Drug Administration Office of Women's Health: Impact of Science on Regulatory Policy: An Update

    PubMed Central

    Elahi, Merina; Eshera, Noha; Bambata, Nkosazana; Barr, Helen; Lyn-Cook, Beverly; Beitz, Julie; Rios, Maria; Taylor, Deborah R.; Lightfoote, Marilyn; Hanafi, Nada; DeJager, Lowri; Wiesenfeld, Paddy; Scott, Pamela E.; Henderson, Marsha B.

    2016-01-01

    Abstract The U.S. Food and Drug Administration Office of Women's Health (FDA OWH) has supported women's health research for ∼20 years, funding more than 300 studies on women's health issues, including research on diseases/conditions that disproportionately affect women in addition to the evaluation of sex differences in the performance of and response to medical products. These important women's health issues are studied from a regulatory perspective, with a focus on improving and optimizing medical product development and the evaluation of product safety and efficacy in women. These findings have influenced industry direction, labeling, product discontinuation, safety notices, and clinical practice. In addition, OWH-funded research has addressed gaps in the knowledge about diseases and medical conditions that impact women across the life span such as cardiovascular disease, pregnancy, menopause, osteoporosis, and the safe use of numerous medical products. PMID:26871618

  8. Advancing Research on Developmental Plasticity: Integrating the Behavioral Science and Neuroscience of Mental Health. Proceedings (Chantilly, Virginia, May 12-15, 1996).

    ERIC Educational Resources Information Center

    Hann, Della M., Ed.; Huffman, Lynne C., Ed.; Lederhendler, Israel I., Ed.; Meinecke, Douglas, Ed.

    This book represents the proceedings of the Conference on Advancing Research on Developmental Plasticity: Integrating Behavioral Science and the Neuroscience of Mental Health. The conference featured scientific presentations from many leading scientists in behavioral sciences, neuroscience and psychiatry, as well as a poster session for newer…

  9. Advances in materials science, Metals and Ceramics Division. Triannual progress report, October 1979-January 1980

    SciTech Connect

    Not Available

    1980-03-31

    Progress is summarized concerning magnetic fusion energy materials, laser fusion energy, aluminium-air battery and vehicle, geothermal research, oil-shale research, nuclear waste management, office of basic energy sciences research, and materials research notes. (FS)

  10. Advanced Hybrid On-Board Science Data Processor - SpaceCube 2.0

    NASA Technical Reports Server (NTRS)

    Flatley, Tom

    2010-01-01

    Topics include an overview of On-board science data processing, software upset mitigation, on-board data reduction, on-board products, HyspIRI demonstration testbed, SpaceCube 2.0 block diagram, and processor comparison.

  11. Shaping Watersheds Exhibit: An Interactive, Augmented Reality Sandbox for Advancing Earth Science Education

    NASA Astrophysics Data System (ADS)

    Reed, S. E.; Kreylos, O.; Hsi, S.; Kellogg, L. H.; Schladow, G.; Yikilmaz, M. B.; Segale, H.; Silverman, J.; Yalowitz, S.; Sato, E.

    2014-12-01

    One of the challenges involved in learning earth science is the visualization of processes which occur over large spatial and temporal scales. Shaping Watersheds is an interactive 3D exhibit developed with support from the National Science Foundation by a team of scientists, science educators, exhibit designers, and evaluation professionals, in an effort to improve public understanding and stewardship of freshwater ecosystems. The hands-on augmented reality sandbox allows users to create topographic models by shaping real "kinetic" sand. The exhibit is augmented in real time by the projection of a color elevation map and contour lines which exactly match the sand topography, using a closed loop of a Microsoft Kinect 3D camera, simulation and visualization software, and a data projector. When an object (such as a hand) is sensed at a particular height above the sand surface, virtual rain appears as a blue visualization on the surface and a flow simulation (based on a depth-integrated version of the Navier-Stokes equations) moves the water across the landscape. The blueprints and software to build the sandbox are freely available online (http://3dh2o.org/71/) under the GNU General Public License, together with a facilitator's guide and a public forum (with how-to documents and FAQs). Using these resources, many institutions (20 and counting) have built their own exhibits to teach a wide variety of topics (ranging from watershed stewardship, hydrology, geology, topographic map reading, and planetary science) in a variety of venues (such as traveling science exhibits, K-12 schools, university earth science departments, and museums). Additional exhibit extensions and learning modules are planned such as tsunami modeling and prediction. Moreover, a study is underway at the Lawrence Hall of Science to assess how various aspects of the sandbox (such as visualization color scheme and level of interactivity) affect understanding of earth science concepts.

  12. Recent Advances in Electron Tomography: TEM and HAADF-STEM Tomography for Materials Science and IC Applications

    SciTech Connect

    Kubel, C; Voigt, A; Schoenmakers, R; Otten, M; Su, D; Lee, T; Carlsson, A; Engelmann, H; Bradley, J

    2005-11-09

    Electron tomograph tomography is a well y well-established technique for three-dimensional structure determination of (almost) amorphous specimens in life science applications. With the recent advances in nanotechnology and the semiconductor industry, there is also an increasing need for high-resolution 3D structural information in physical sciences. In this paper, we evaluate the capabilities and limitations of TEM and HAADF-STEM tomography for the 3D structural characterization of partially crystalline to highly crystalline materials. Our analysis of catalysts, a hydrogen storage material, and different semiconductor devices shows that features with a diameter as small as 1-2 nm can be resolved in 3D by electron tomography. For partially crystalline materials with small single crystalline domains, TEM tomography provides reliable 3D structural information. HAADF-STEM tomography is more versatile and can also be used for high-resolution 3D imaging of highly crystalline materials such as semiconductor devices.

  13. The NASA/GSFC Advanced Data Grid: A Prototype for Future Earth Science Ground System Architectures

    NASA Technical Reports Server (NTRS)

    Gasster, Samuel D.; Lee, Craig; Davis, Brooks; Clark, Matt; AuYeung, Mike; Wilson, John R.; Ladwig, Debra M.

    2003-01-01

    Contents include the following: Background and motivation. Grid computing concepts. Advanced data grid (ADG) prototype development. ADG requirements and operations concept. ADG architecture. ADG implementation. ADG test plan. ADG schedule. Summary and status.

  14. 78 FR 66021 - National Center for Advancing Translational Sciences; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... NCATS might optimally exercise its flexible research authority by using transactions other than grants... include the name, address, telephone number and when applicable, the business or professional affiliation... HUMAN SERVICES National Institutes of Health National Center for Advancing Translational...

  15. Advancing participation of blind students in Science, Technology, Engineering, and Math

    NASA Astrophysics Data System (ADS)

    Beck-Winchatz, Bernhard; Riccobono, Mark A.

    2008-12-01

    Like their sighted peers, many blind students in elementary, middle, and high school are naturally interested in space. This interest can motivate them to learn fundamental scientific, quantitative, and critical thinking skills, and sometimes even lead to careers in Science, Technology, Engineering, and Math (STEM) disciplines. However, these students are often at a disadvantage in science because of the ubiquity of important graphical information that is generally not available in accessible formats, the unfamiliarity of teachers with non-visual teaching methods, lack of access to blind role models, and the low expectations of their teachers and parents. We discuss joint efforts by the National Aeronautics and Space Administration (NASA) and the National Federation of the Blind’s (NFB) National Center for Blind Youth in Science (NCBYS) to develop and implement strategies to promote opportunities for blind youth in science. These include the development of tactile space science books and curriculum materials, science academies for blind middle school and high school students, and college-level internship and mentoring programs. The partnership with the NFB exemplifies the effectiveness of collaborations between NASA and consumer-directed organizations to improve opportunities for underserved and underrepresented individuals.

  16. Advances and Challenges In Uncertainty Quantification with Application to Climate Prediction, ICF design and Science Stockpile Stewardship

    NASA Astrophysics Data System (ADS)

    Klein, R.; Woodward, C. S.; Johannesson, G.; Domyancic, D.; Covey, C. C.; Lucas, D. D.

    2012-12-01

    Uncertainty Quantification (UQ) is a critical field within 21st century simulation science that resides at the very center of the web of emerging predictive capabilities. The science of UQ holds the promise of giving much greater meaning to the results of complex large-scale simulations, allowing for quantifying and bounding uncertainties. This powerful capability will yield new insights into scientific predictions (e.g. Climate) of great impact on both national and international arenas, allow informed decisions on the design of critical experiments (e.g. ICF capsule design, MFE, NE) in many scientific fields, and assign confidence bounds to scientifically predictable outcomes (e.g. nuclear weapons design). In this talk I will discuss a major new strategic initiative (SI) we have developed at Lawrence Livermore National Laboratory to advance the science of Uncertainty Quantification at LLNL focusing in particular on (a) the research and development of new algorithms and methodologies of UQ as applied to multi-physics multi-scale codes, (b) incorporation of these advancements into a global UQ Pipeline (i.e. a computational superstructure) that will simplify user access to sophisticated tools for UQ studies as well as act as a self-guided, self-adapting UQ engine for UQ studies on extreme computing platforms and (c) use laboratory applications as a test bed for new algorithms and methodologies. The initial SI focus has been on applications for the quantification of uncertainty associated with Climate prediction, but the validated UQ methodologies we have developed are now being fed back into Science Based Stockpile Stewardship (SSS) and ICF UQ efforts. To make advancements in several of these UQ grand challenges, I will focus in talk on the following three research areas in our Strategic Initiative: Error Estimation in multi-physics and multi-scale codes ; Tackling the "Curse of High Dimensionality"; and development of an advanced UQ Computational Pipeline to enable

  17. A restatement of recent advances in the natural science evidence base concerning neonicotinoid insecticides and insect pollinators

    PubMed Central

    Godfray, H. Charles J.; Blacquière, Tjeerd; Field, Linda M.; Hails, Rosemary S.; Potts, Simon G.; Raine, Nigel E.; Vanbergen, Adam J.; McLean, Angela R.

    2015-01-01

    A summary is provided of recent advances in the natural science evidence base concerning the effects of neonicotinoid insecticides on insect pollinators in a format (a ‘restatement') intended to be accessible to informed but not expert policymakers and stakeholders. Important new studies have been published since our recent review of this field (Godfray et al. 2014 Proc. R. Soc. B 281, 20140558. (doi:10.1098/rspb.2014.0558)) and the subject continues to be an area of very active research and high policy relevance. PMID:26511042

  18. Advancing the Interdisciplinary Collaborative Health Team Model: Applying Democratic Professionalism, Implementation Science, and Therapeutic Alliance to Enact Social Justice Practice.

    PubMed

    Murphy, Nancy

    2015-01-01

    This essay reframes the interdisciplinary collaborative health team model by proposing the application of 3 foundational pillars-democratic professionalism, implementation science, and therapeutic alliance to advance this practice. The aim was to address challenges to the model, enhance their functional capacity, and explicate and enact social justice practices to affect individual health outcomes while simultaneously addressing health inequities. The pillars are described and examples from the author's dissertation research illustrate how the pillars were used to bring about action. Related theories, models, and frameworks that have negotiation, capacity building, collaboration, and knowledge/task/power sharing as central concepts are presented under each of the pillars. PMID:26244478

  19. A restatement of recent advances in the natural science evidence base concerning neonicotinoid insecticides and insect pollinators.

    PubMed

    Godfray, H Charles J; Blacquière, Tjeerd; Field, Linda M; Hails, Rosemary S; Potts, Simon G; Raine, Nigel E; Vanbergen, Adam J; McLean, Angela R

    2015-11-01

    A summary is provided of recent advances in the natural science evidence base concerning the effects of neonicotinoid insecticides on insect pollinators in a format (a 'restatement') intended to be accessible to informed but not expert policymakers and stakeholders. Important new studies have been published since our recent review of this field (Godfray et al. 2014 Proc. R. Soc. B 281, 20140558. (doi:10.1098/rspb.2014.0558)) and the subject continues to be an area of very active research and high policy relevance. PMID:26511042

  20. The effects of advance organizer and prerequisite knowledge passages on the learning and retention of science concepts

    NASA Astrophysics Data System (ADS)

    Healy, Vivian C.

    Fifty-five ninth-grade science students participated in this study which compared the effects of two pretreatments, an advance organizer and a prerequisite knowledge passage, on learning and retention measured at low (knowledge and comprehension) and high (application and analysis) levels of the cognitive domain. The effectiveness of the pretreatments was measured by a framework test and a prerequisite knowledge test prior to the beginning of instruction. An analysis of covariance, with IQ as the covariate, was performed on the framework test and the prerequisite knowledge test. It was found that the advance organizer group performed significantly better than the prerequisite knowledge group (p < 0.001) on the first framework test, and the prerequisite knowledge group performed significantly better (p < 0.001) than the advance organizer group on the prerequisite knowledge test. These results provide evidence that both passages were read and understood by the students and that the passages had their intended effects as preinstructional treatments. An analysis of covariance, with IQ as the covariate, was performed on the low-level questions, high-level questions, and total score for the posttest and retention test. The group means for the two question levels and the total score were not found to be significantly different (p > 0.05) for either the posttest or retention test. The results of this study do not provide evidence that an advance organizer facilitates learning and retention more than a preinstructional treatment that concentrates on developing prerequisite knowledge.

  1. Launch Vehicles Based on Advanced Hybrid Rocket Motors: An Enabling Technology for the Commercial Small and Micro Satellite Planetary Science

    NASA Astrophysics Data System (ADS)

    Karabeyoglu, Arif; Tuncer, Onur; Inalhan, Gokhan

    2016-07-01

    Mankind is relient on chemical propulsion systems for space access. Nevertheless, this has been a stagnant area in terms of technological development and the technology base has not changed much almost for the past forty years. This poses a vicious circle for launch applications such that high launch costs constrain the demand and low launch freqencies drive costs higher. This also has been a key limiting factor for small and micro satellites that are geared towards planetary science. Rather this be because of the launch frequencies or the costs, the access of small and micro satellites to orbit has been limited. With today's technology it is not possible to escape this circle. However the emergence of cost effective and high performance propulsion systems such as advanced hybrid rockets can decrease launch costs by almost an order or magnitude. This paper briefly introduces the timeline and research challenges that were overcome during the development of advanced hybrid LOX/paraffin based rockets. Experimental studies demonstrated effectiveness of these advanced hybrid rockets which incorporate fast burning parafin based fuels, advanced yet simple internal balistic design and carbon composite winding/fuel casting technology that enables the rocket motor to be built from inside out. A feasibility scenario is studied using these rocket motors as building blocks for a modular launch vehicle capable of delivering micro satellites into low earth orbit. In addition, the building block rocket motor can be used further solar system missions providing the ability to do standalone small and micro satellite missions to planets within the solar system. This enabling technology therefore offers a viable alternative in order to escape the viscous that has plagued the space launch industry and that has limited the small and micro satellite delivery for planetary science.

  2. The U.S. Geological Survey Ecosystem Science Strategy, 2012-2022 - Advancing discovery and application through collaboration

    USGS Publications Warehouse

    Williams, Byron K.; Wingard, G. Lynn; Brewer, Gary; Cloern, James; Gelfenbaum, Guy; Jacobson, Robert B.; Kershner, Jeffrey L.; McGuire, Anthony David; Nichols, James D.; Shapiro, Carl D.; van Riper, Charles, III; White, Robin P.

    2012-01-01

    technologies for data collection, management, and visualization. Collectively, these capabilities can be used to reveal ecological patterns and processes, explain how and why ecosystems change, and forecast change over different spatial and temporal scales. USGS science can provide managers with options and decision-support tools to use resources sustainably. The USGS has long-standing, collaborative relationships with the DOI and other partners in the natural sciences, in both conducting science and its application. The USGS engages these partners in cooperative investigations that otherwise would lack the necessary support or be too expensive for a single bureau to conduct. The heart of this strategy is a framework and vision for USGS ecosystems science that focuses on five long-term goals, which are seen as interconnected and reinforcing components: * Improve understanding of ecosystem structure, function, and processes. The focus for this goal is an understanding of how ecosystems work, including the dynamics of species, their populations, interactions, and genetics, and how they change across spatial and temporal scales. * Advance understanding of how drivers influence ecosystem change. The challenges here are explaining the drivers of ecosystem change, their spatio-temporal patterns, their uncertainties and interactions, and their influence on ecosystem processes and dynamics. * Improve understanding of the services that ecosystems provide to society. Here the emphasis is on the measurement of environmental capital and ecosystem services, and the identification of sources and patterns of change in space and time. * Develop tools, technologies, and capacities to inform decision-making about ecosystems. This includes developing new technologies and approaches for conducting applications-oriented ecosystem science. A principal challenge will be how to quantify uncertainty and incorporate it in decision analysis. * Apply science to enhance strategies for management

  3. Taming Typhon: Advancing Climate Literacy by Coordinating Federal Earth System Science Education Investments Through the U.S. Climate Change Science Program

    NASA Astrophysics Data System (ADS)

    Karsten, J. L.; Niepold, F.; Wei, M.; Waple, A. M.

    2008-12-01

    Thirteen Federal agencies in the United States invest in research, communication, and education activities related to climate and global change. The U.S. Climate Change Science Program (CCSP) works to integrate the research activities of these different agencies, with oversight from the Office of Science and Technology Policy, the Council on Environmental Quality, the National Economic Council and the Office of Management and Budget. The CCSP is the result of a Presidential initative in 2001 to build on the Global Change Research Program, which exists as a result of the Global Change Research Act of 1990. This initiative was to shift the focus of the Program from 'discovery and characterization' to 'differentiation and strategy investigation.' With this shift, CCSP's focus is now on evaluating optimal strategies for addressing climate change risks, improving coordination among the Federal agencies, communicating research results to all stakeholders (including national policy leaders and local resource managers), and improving public debate and decision-making related to global change. Implicit to these activities is the need to educate the general public about the science of climate change and its consequences, as well as coordinate Federal investments related to climate change education. This is no small task, given the variety of missions and approaches of the participating agencies. Recognizing that its Communications Interagency Working Group (CIWG) does not have the expertise or focus to adequately address issues related to science education, the CCSP recently established an ad-hoc Education Interagency Working Group (EIWG), comprising representatives from all 13 agencies, that will work closely with the CIWG to enhance education goals. Its mission is to advance literacy in climate and related sciences and increase informed decision making for the Nation. The EIWG envisions that its primary activities in the near-term will be focused on establishing: (1) a

  4. Develop, Discuss, and Decide: How New Science Teachers Use Technologies to Advance Their Practice

    NASA Astrophysics Data System (ADS)

    Ellis, Joshua Alexander

    For decades, there has been a nationwide demand to increase the number of science teachers in K-12 education (National Commission on Excellence in Education, 1983; National Research Council [NRC], 2007). This demand is in large part due to increases in state science graduation requirements. Teacher preparation programs have been preparing new science teachers on pace with the resulting increase in demand (Ingersoll & Merrill, 2010), however, shortages have continued as up to 50% of these new teachers leave the profession within their first five years of teaching (Smith & Ingersoll, 2004), creating a "revolving door" phenomenon as districts scramble to address this early attrition with yet more beginning teachers. We need to address what Ingersoll (2012) describes as the "greening" of the teaching force: the fact that an increasingly large segment of the teaching force is comprised of beginning teachers who are at a high risk of leaving the profession. The three related studies that comprise this dissertation focus on the role of technological interventions for in-service and pre-service science teachers. The context for the first two studies is TIN, an online induction program for beginning secondary science teachers. These two studies consider the impact of technological supports on the reflective practice of participating teachers. The design interventions included VideoANT (an online video annotation tool) and Teachers as Leaders roles (a structured response protocol) for the Venture/Vexation online forum activity. The context for the third study is T3-S, a university licensure course for pre-service science teachers designed to explore technology integration in secondary science classrooms. This study investigated the impact of pre-service teacher participation in the creation of an Adventure Learning (AL) environment (Doering, 2006) on their understanding of technological, pedagogical, and content knowledge (TPACK) and its role in their future science

  5. Advancing One Health Policy and Implementation Through the Concept of One Medicine One Science

    PubMed Central

    Cardona, Carol; Travis, Dominic A.; Berger, Kavita; Coat, Gwenaële; Kennedy, Shaun; Steer, Clifford J.; Murtaugh, Michael P.

    2015-01-01

    Numerous interspecies disease transmission events, Ebola virus being a recent and cogent example, highlight the complex interactions between human, animal, and environmental health and the importance of addressing medicine and health in a comprehensive scientific manner. The diversity of information gained from the natural, social, behavioral, and systems sciences is critical to developing and sustainably promoting integrated health approaches that can be implemented at the local, national, and international levels to meet grand challenges. The Concept of One Medicine One Science (COMOS) as outlined herein describes the interplay between scientific knowledge that underpins health and medicine and efforts toward stabilizing local systems using 2 linked case studies: the food system and emerging infectious disease. Forums such as the International Conference of One Medicine One Science (iCOMOS), where science and policy can be debated together, missing pieces identified, and science-based collaborations formed among industry, governmental, and nongovernmental policy makers and funders, is an essential step in addressing global health. The expertise of multiple disciplines and research foci to support policy development is critical to the implementation of one health and the successful achievement of global health security goals. PMID:26421234

  6. Comparing Self-Regulatory and Early Academic Skills as Predictors of Later Math, Reading, and Science Elementary School Achievement

    NASA Astrophysics Data System (ADS)

    Murrah, William M., III

    The achievement score gaps between advantaged and disadvantaged children at school entry is a major problem in education today. Identifying the skills critical for school readiness is an important step in developing interventions aimed at addressing these score gaps. The purpose of this study is to compare a number of school readiness skills with an eye toward finding out which are the best predictors of later academic achievement in math, reading, and science. The predictors were early reading, math, general knowledge, socioemotional skills, and motor skills. Data were obtained from the Early Childhood Longitudinal Study of 1998 (NCES, 1998) database. While controlling for an extensive set of family characteristics, predictions were made across five years - from the end of kindergarten to the end of fifth grade. Consistent with current findings, reading and math skills predicted later achievement. Interestingly, general knowledge, attention, and fine motor skills also proved to be important predictors of later academic achievement, but socioemotional skills were not. The findings were interpreted from a neurobiological perspective involving the development of self-regulation. These school entry skills are used to predict later achievement in reading, math, and science. I argued that in addition to acquiring early academic knowledge, children need to regulate the use of this knowledge to meet academic goals.

  7. Synthesizing Marketing, Community Engagement, and Systems Science Approaches for Advancing Translational Research.

    PubMed

    Kneipp, Shawn M; Leeman, Jennifer; McCall, Pamela; Hassmiller-Lich, Kristen; Bobashev, Georgiy; Schwartz, Todd A; Gilmore, Robert; Riggan, Scott; Gil, Benjamin

    2015-01-01

    The adoption and implementation of evidence-based interventions (EBIs) are the goals of translational research; however, potential end-users' perceptions of an EBI value have contributed to low rates of adoption. In this article, we describe our application of emerging dissemination and implementation science theoretical perspectives, community engagement, and systems science principles to develop a novel EBI dissemination approach. Using consumer-driven, graphics-rich simulation, the approach demonstrates predicted implementation effects on health and employment outcomes for socioeconomically disadvantaged women at the local level and is designed to increase adoption interest of county program managers accountable for improving these outcomes in their communities. PMID:26244479

  8. Development, Evaluation and Use of a Student Experience Survey in Undergraduate Science Laboratories: The Advancing Science by Enhancing Learning in the Laboratory Student Laboratory Learning Experience Survey

    NASA Astrophysics Data System (ADS)

    Barrie, Simon C.; Bucat, Robert B.; Buntine, Mark A.; Burke da Silva, Karen; Crisp, Geoffrey T.; George, Adrian V.; Jamie, Ian M.; Kable, Scott H.; Lim, Kieran F.; Pyke, Simon M.; Read, Justin R.; Sharma, Manjula D.; Yeung, Alexandra

    2015-07-01

    Student experience surveys have become increasingly popular to probe various aspects of processes and outcomes in higher education, such as measuring student perceptions of the learning environment and identifying aspects that could be improved. This paper reports on a particular survey for evaluating individual experiments that has been developed over some 15 years as part of a large national Australian study pertaining to the area of undergraduate laboratories-Advancing Science by Enhancing Learning in the Laboratory. This paper reports on the development of the survey instrument and the evaluation of the survey using student responses to experiments from different institutions in Australia, New Zealand and the USA. A total of 3153 student responses have been analysed using factor analysis. Three factors, motivation, assessment and resources, have been identified as contributing to improved student attitudes to laboratory activities. A central focus of the survey is to provide feedback to practitioners to iteratively improve experiments. Implications for practitioners and researchers are also discussed.

  9. Decision aids for advance care planning: an overview of the state of the science.

    PubMed

    Butler, Mary; Ratner, Edward; McCreedy, Ellen; Shippee, Nathan; Kane, Robert L

    2014-09-16

    Advance care planning honors patients' goals and preferences for future care by creating a plan for when illness or injury impedes the ability to think or communicate about health decisions. Fewer than 50% of severely or terminally ill patients have an advance directive in their medical record, and physicians are accurate only about 65% of the time when predicting patient preferences for intensive care. Decision aids can support the advance care planning process by providing a structured approach to informing patients about care options and prompting them to document and communicate their preferences. This review, commissioned as a technical brief by the Agency for Healthcare Research and Quality Effective Health Care Program, provides a broad overview of current use of and research related to decision aids for adult advance care planning. Using interviews of key informants and a search of the gray and published literature from January 1990 to May 2014, the authors found that many decision aids are widely available but are not assessed in the empirical literature. The 16 published studies testing decision aids as interventions for adult advance care planning found that most are proprietary or not publicly available. Some are constructed for the general population, whereas others address disease-specific conditions that have more predictable end-of-life scenarios and, therefore, more discrete choices. New decision aids should be designed that are responsive to diverse philosophical perspectives and flexible enough to change as patients gain experience with their personal illness courses. Future efforts should include further research, training of advance care planning facilitators, dissemination and access, and tapping potential opportunities in social media or other technologies. PMID:25069709

  10. Preserving the Art and Science of Psychotherapy for Advance Practice Psychiatric Mental Health Nurses.

    PubMed

    Caughill, Ann

    2016-04-01

    Psychiatric Mental Health (PMH) Nurses are challenged to maintain the viability of their roles in today's healthcare climate as advances in research and complexity of mental healthcare needs of society continue to unfold. Today's mental health practice environment includes disciplines with marketable credentials. Roles for PMH nurses in recent decades are less clearly defined than for other disciplines, much of this related to changes in educational and practice settings. This article reviews literature on the topic of psychotherapy and a call for a renewed emphasis on this mode of treatment for psychiatric mental health advance practice nurses. PMID:27077508

  11. POTENTIAL IMPACTS OF GENOMICS ON EPA REGULATORY AND RISK ASSESSMENT APPLICATIONS

    EPA Science Inventory

    Gallagher, Kathryn and William Benson. In press. Potential Impacts of Genomics on EPA Regulatory and Risk Assessment (Abstract). To be presented at the EPA Science Forum: Healthy Communities and Ecosystems, 1-3 June 2004, Washington, DC. 1 p. (ERL,GB R991).

    Advances in ge...

  12. Preservice Teachers as Investigative Science Mentors: Advancing Self-Efficacy through School-Based Professional Development

    ERIC Educational Resources Information Center

    Flores, Ingrid M.

    2015-01-01

    Pedagogical competence and teaching efficacy significantly influence the quality of classroom science learning. Without applying pedagogical learning in realistic classroom environments, there is slight possibility that prospective teachers will increase their teaching confidence or develop understanding of how learners acquire and construct…

  13. Data Generation in the Discovery Sciences--Learning from the Practices in an Advanced Research Laboratory

    ERIC Educational Resources Information Center

    Roth, Wolff-Michael

    2013-01-01

    General scientific literacy includes understanding the grounds on which scientific claims are based. The measurements scientists make and the data that they produce from them generally constitute these grounds. However, the nature of data generation has received relatively little attention from those interested in teaching science through inquiry.…

  14. The Hamovitch Research Center: An Experiment in Collective Responsibility for Advancing Science in the Human Services

    ERIC Educational Resources Information Center

    Flynn, Marilyn; Brekke, John S.; Soydan, Haluk

    2008-01-01

    Research centers in schools of social work are growing in number and scope. In this article the authors argue that this increase is in line with the growing recognition that research and science are critical components of the mission of the social work profession. The authors examine the purposes and various models for establishing research…

  15. Advanced Placement Math and Science Courses: Influential Factors and Predictors for Success in College STEM Majors

    ERIC Educational Resources Information Center

    Hoepner, Cynthia Colon

    2010-01-01

    President Obama has recently raised awareness on the need for our nation to grow a larger pool of students with knowledge in science mathematics, engineering, and technology (STEM). Currently, while the number of women pursuing college degrees continues to rise, there remains an under-representation of women in STEM majors across the country.…

  16. Recent Advances and Issues in Computers. Oryx Frontiers of Science Series.

    ERIC Educational Resources Information Center

    Gay, Martin K.

    Discussing recent issues in computer science, this book contains 11 chapters covering: (1) developments that have the potential for changing the way computers operate, including microprocessors, mass storage systems, and computing environments; (2) the national computational grid for high-bandwidth, high-speed collaboration among scientists, and…

  17. Science-Based Advances in the Social Domain of Learning Disabilities

    ERIC Educational Resources Information Center

    Bryan, Tanis

    2005-01-01

    Over the past 20 years, teachers have been under continuous pressure to increase students' academic achievement gains. The No Child Left Behind Act of 2001 (NCLB), the latest effort in the 20+-year-old school reform movement, is a federal mandate that demands in part that school districts implement science-based instructional strategies to ensure…

  18. National Energy Research Scientific Computing Center (NERSC): Advancing the frontiers of computational science and technology

    SciTech Connect

    Hules, J.

    1996-11-01

    National Energy Research Scientific Computing Center (NERSC) provides researchers with high-performance computing tools to tackle science`s biggest and most challenging problems. Founded in 1974 by DOE/ER, the Controlled Thermonuclear Research Computer Center was the first unclassified supercomputer center and was the model for those that followed. Over the years the center`s name was changed to the National Magnetic Fusion Energy Computer Center and then to NERSC; it was relocated to LBNL. NERSC, one of the largest unclassified scientific computing resources in the world, is the principal provider of general-purpose computing services to DOE/ER programs: Magnetic Fusion Energy, High Energy and Nuclear Physics, Basic Energy Sciences, Health and Environmental Research, and the Office of Computational and Technology Research. NERSC users are a diverse community located throughout US and in several foreign countries. This brochure describes: the NERSC advantage, its computational resources and services, future technologies, scientific resources, and computational science of scale (interdisciplinary research over a decade or longer; examples: combustion in engines, waste management chemistry, global climate change modeling).

  19. The Interrelationships among Science, Art, and Values: Significance for Advancing Holistic Excellence.

    ERIC Educational Resources Information Center

    Erez, Ronny

    2001-01-01

    The Israel Arts and Science Academy for gifted secondary students is described. The goal of the academy is to graduate learners who will apply their gifts to the betterment of the human condition. The Greek ideal of the unity of truth, beauty, and goodness serves as the central curricular force. (Contains three references.) (Author/CR)

  20. U.S. Geological Survey Ecosystems science strategy: advancing discovery and application through collaboration

    USGS Publications Warehouse

    Williams, Byron K.; Wingard, G. Lynn; Brewer, Gary; Cloern, James E.; Gelfenbaum, Guy; Jacobson, Robert B.; Kershner, Jeffrey L.; McGuire, Anthony David; Nichols, James D.; Shapiro, Carl D.; van Riper, Charles, III; White, Robin P.

    2013-01-01

    Ecosystem science is critical to making informed decisions about natural resources that can sustain our Nation’s economic and environmental well-being. Resource managers and policymakers are faced with countless decisions each year at local, regional, and national levels on issues as diverse as renewable and nonrenewable energy development, agriculture, forestry, water supply, and resource allocations at the urbanrural interface. The urgency for sound decisionmaking is increasing dramatically as the world is being transformed at an unprecedented pace and in uncertain directions. Environmental changes are associated with natural hazards, greenhouse gas emissions, and increasing demands for water, land, food, energy, mineral, and living resources. At risk is the Nation’s environmental capital, the goods and services provided by resilient ecosystems that are vital to the health and wellbeing of human societies. Ecosystem science—the study of systems of organisms interacting with their environment and the consequences of natural and human-induced change on these systems—is necessary to inform decisionmakers as they develop policies to adapt to these changes. This Ecosystems Science Strategy is built on a framework that includes basic and applied science. It highlights the critical roles that U.S. Geological Survey (USGS) scientists and partners can play in building scientific understanding and providing timely information to decisionmakers. The strategy underscores the connection between scientific discoveries and the application of new knowledge, and it integrates ecosystem science and decisionmaking, producing new scientific outcomes to assist resource managers and providing public benefits. We envision the USGS as a leader in integrating scientific information into decisionmaking processes that affect the Nation’s natural resources and human well-being. The USGS is uniquely positioned to play a pivotal role in ecosystem science. With its wide range of

  1. Effects of the Integrated Online Advance Organizer Teaching Materials on Students' Science Achievement and Attitude

    ERIC Educational Resources Information Center

    Korur, Fikret; Toker, Sacip; Eryilmaz, Ali

    2016-01-01

    This two-group quasi-experimental study investigated the effects of the Online Advance Organizer Concept Teaching Material (ONACOM) integrated with inquiry teaching and expository teaching methods. Grade 7 students' posttest performances on the light unit achievement and light unit attitude tests controlled for gender, previous semester science…

  2. Genomic Advances to Improve Biomass for Biofuels (LBNL Science at the Theater)

    ScienceCinema

    Rokhsar, Daniel

    2011-04-28

    Lawrence Berkeley National Lab bioscientist Daniel Rokhsar discusses genomic advances to improve biomass for biofuels. He presented his talk Feb. 11, 2008 in Berkeley, California as part of Berkeley Lab's community lecture series. Rokhsar works with the U.S. Department of Energy's Joint Genome Institute and Berkeley Lab's Genomics Division.

  3. Big Fleas Have Little Fleas: How discoveries of invertebrate diseases are advancing modern science.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Review of: “Big Fleas Have Little Fleas: How discoveries of invertebrate diseases are advancing modern science”. Elizabeth W. Davdison. 2006. The University of Arizona Press, Tucson, AZ. 208 pp. Dr. Davidson links many of the accomplishments in invertebrate pathology to subsequent successes in the l...

  4. Describing Learning in An Advanced Online Case-Based Course in Environmental Science

    ERIC Educational Resources Information Center

    Missett, Tracy C.; Reed, Christine B.; Scot, Tammy P.; Callahan, Carolyn M.; Slade, Mary

    2010-01-01

    Researchers increasingly embrace online courses to compensate for lack of access to educational opportunities otherwise available in traditional school settings. Researchers also recommend alternatives to traditional AP coursework to better meet the diverse learning styles and needs of advanced learners. These recommendations have particular…

  5. Methodological Advances in Research on Learning and Instruction and in the Learning Sciences

    ERIC Educational Resources Information Center

    Fischer, Frank; Järvelä, Sanna

    2014-01-01

    Recent years have seen a dynamic growth of research communities addressing conditions, processes and outcomes of learning in formal and informal environments. Two of them have markedly advanced the field: The community on research on learning and instruction that has been organized in the European Association for Research on Learning and…

  6. Assessing the Best: NAEP's 1996 Assessment of Twelfth-Graders Taking Advanced Science Courses.

    ERIC Educational Resources Information Center

    O'Sullivan, Christine Y.; Grigg, Wendy S.

    This report presents the results of a study conducted during the 1995-1996 school year to evaluate the educational progress of 12th grade students taking advanced biology, chemistry, and physics courses. The study was conducted by the National Center for Education Statistics (NCES) in association with the National Assessment of Educational…

  7. The Effects of Advance Organizers upon the Reception Learning and Retention of General Science Content.

    ERIC Educational Resources Information Center

    Barron, Richard F.

    David P. Ausubel (1963, 1968) has developed a psychology of meaningful reception learning which is intimately related to instruction as it typically occurs in schools. A key component of this psychology involves the hypothesized effects of advance organizers has not been adequately evaluated. Previous investigations, while of theoretical interest,…

  8. Advance the Earth Science Education in China by Using New Technology

    NASA Astrophysics Data System (ADS)

    Qian, R.; Wang, X.; Sun, L.

    2013-12-01

    With the development of Chinese economy, science and technology, as well as the increasing demand of the persons with knowledge and experience in earth science and geological exploration, the higher education of earth science has been boosted in recent years. There are 2,000 to 3,000 students studying earth science every year and many of them will take part in scientific research and engineering technology work around the world after graduation, which increased the demand of educators, both in quantity and quality. However, the fact is that there is a huge gap between the demand and the current number of educators due to the explosion of students, which makes the reform of traditional education methods inevitable. There is great significance in doing research on the teaching methods catering to a large number of students. Some research contents and result based on the reform of education methods has been conducted. We integrate the teaching contents with the cutting-edge research projects and stress significance of earth science, which will greatly enhance the student's enthusiasm of it. Moreover. New technology will be applied to solve the problem that every teacher are responsible for 100~150 students in one courses. For instance, building the Internet platform where teachers and the students can discuss the courses contents, read the latest scientific articles. With the numerical simulation technology, the internal structure of the Earth, geological phenomena, characteristics of ore body, geophysical and hydrological fields, etc. can be simulated and the experiments and teaching practice can be demonstrated via video technology. It can also be used to design algorithm statistics and assessment and monitor teaching effect. Students are separated into small groups to take research training with their personal tutor at the beginning of the first semester, which will increase the opportunities for students to communicate with educators and solve the problem that the

  9. Tackling diversity challenges in Geoscience with the "Advancing Space Science Undergraduate Research Experience" (ASSURE) program at UC Berkeley's Space Sciences Laboratory.

    NASA Astrophysics Data System (ADS)

    Raftery, C. L.; Paglierani, R.; Shackelford, R. L., III; Peticolas, L. M.; Frappier, R.; Mendez, B.

    2014-12-01

    The Space Sciences Laboratory (SSL) has a long history of undergraduates working within the various research groups that range from theoretical astrophysics through to mechanical engineering. This year, we have established for the first time, a formal summer program for the undergraduate students, focusing on students traditionally underserved in Geosciences. This program, called the Advancing Space Science through Undergraduate Research Experiences program brings best-practiced methods to the development of a cohort, academic achievement, and research methodologies to the summer interns, with emphasis on the needs of underrepresented students who have not been exposed to a research environment before. In addition, specific care was given when recruiting for the program. Community College students recommend to us by faculty partners within the Colleges were recruited in order to provide them with hands on experience in a laboratory setting that they would not otherwise have had. In addition, we selected a number of pre- and in-service teachers from the STEM Teacher and Researcher Program (STAR) program. The combination of these two demographics of students has provided a unique and supportive environment for all involved.

  10. Advances in Using Opensearch for Earth Science Data Discovery and Interoperability

    NASA Astrophysics Data System (ADS)

    Newman, D. J.; Mitchell, A. E.

    2014-12-01

    As per www.opensearch.org: OpenSearch is a collection of simple formats for the sharing of search results A number of organizations (NASA, ESA, CEOS) have began to adopt this standard as a means of allowing both the discovery of earth science data and the aggregation of results from disparate data archives. OpenSearch has proven to be simpler and more effective at achieving these goals than previous efforts (Catalog Service for the web for example). This talk will outline: The basic ideas behind OpenSearch The ways in which we have extended the basic specification to accomodate the Earth Science use case (two-step searching, relevancy ranking, facets) A case-study of the above in action (CWICSmart + IDN OpenSearch + CWIC OpenSearch) The potential for interoperability this simple standard affords A discussion of where we can go in the future

  11. Advancing Navigation, Timing, and Science with the Deep Space Atomic Clock

    NASA Technical Reports Server (NTRS)

    Ely, Todd A.; Seubert, Jill; Bell, Julia

    2014-01-01

    NASA's Deep Space Atomic Clock mission is developing a small, highly stable mercury ion atomic clock with an Allan deviation of at most 1e-14 at one day, and with current estimates near 3e-15. This stability enables one-way radiometric tracking data with accuracy equivalent to and, in certain conditions, better than current two-way deep space tracking data; allowing a shift to a more efficient and flexible one-way deep space navigation architecture. DSAC-enabled one-way tracking will benefit navigation and radio science by increasing the quantity and quality of tracking data. Additionally, DSAC would be a key component to fully-autonomous onboard radio navigation useful for time-sensitive situations. Potential deep space applications of DSAC are presented, including orbit determination of a Mars orbiter and gravity science on a Europa flyby mission.

  12. Recent advances in the applications of CE to forensic sciences (2001-2004).

    PubMed

    Tagliaro, Franco; Bortolotti, Federica

    2006-01-01

    The present article reviews the applications of CE in forensic science covering the period from 2001 until the first part of 2005. The overview includes the most relevant examples of analytical applications of capillary electrophoretic and electrokinetic techniques in the following fields: (i) Forensic drugs and poisons, (ii) explosive analysis and gunshot residues, (iii) small ions of forensic interest, (iv) forensic DNA and RNA analysis, (v) proteins of forensic interest, and (vi) ink analysis. PMID:16421953

  13. Recent advances in the applications of CE to forensic sciences (2005-2007).

    PubMed

    Tagliaro, Franco; Bortolotti, Federica

    2008-01-01

    The present article reviews the applications of CE in forensic science covering the period from 2005 until the first part of 2007. The overview includes the most relevant examples of analytical applications of capillary electrophoretic and electrokinetic techniques in the following fields: (i) forensic drugs, toxicants and dyes, (ii) small ions of forensic interest (iii) explosives, (iv) forensic DNA, and (v) other biopolymers of forensic interest. PMID:18058765

  14. EarthCube: Advancing Partnerships, Collaborative Platforms and Knowledge Networks in the Ocean Sciences

    NASA Astrophysics Data System (ADS)

    Stephen, Diggs; Lee, Allison

    2014-05-01

    The National Science Foundation's EarthCube initiative aims to create a community-driven data and knowledge management system that will allow for unprecedented data sharing across the geosciences. More than 2,500 participants through forums, work groups, EarthCube events, and virtual and in-person meetings have participated. The individuals that have engaged represent the core earth-system sciences of solid Earth, Atmosphere, Oceans, and Polar Sciences. EarthCube is a cornerstone of NSF's Cyberinfrastructure for the 21st Century (CIF21) initiative, whose chief objective is to develop a U.S. nationwide, sustainable, and community-based cyberinfrastructure for researchers and educators. Increasingly effective community-driven cyberinfrastructure allows global data discovery and knowledge management and achieves interoperability and data integration across scientific disciplines. There is growing convergence across scientific and technical communities on creating a networked, knowledge management system and scientific data cyberinfrastructure that integrates Earth system and human dimensions data in an open, transparent, and inclusive manner. EarthCube does not intend to replicate these efforts, but build upon them. An agile development process is underway for the development and governance of EarthCube. The agile approach was deliberately selected due to its iterative and incremental nature while promoting adaptive planning and rapid and flexible response. Such iterative deployment across a variety of EarthCube stakeholders encourages transparency, consensus, accountability, and inclusiveness.

  15. Advances in Climate Informatics: Accelerating Discovery in Climate Science with Machine Learning

    NASA Astrophysics Data System (ADS)

    Monteleoni, C.

    2015-12-01

    Despite the scientific consensus on climate change, drastic uncertainties remain. The climate system is characterized by complex phenomena that are imperfectly observed and even more imperfectly simulated. Climate data is Big Data, yet the magnitude of data and climate model output increasingly overwhelms the tools currently used to analyze them. Computational innovation is therefore needed. Machine learning is a cutting-edge research area at the intersection of computer science and statistics, focused on developing algorithms for big data analytics. Machine learning has revolutionized scientific discovery (e.g. Bioinformatics), and spawned new technologies (e.g. Web search). The impact of machine learning on climate science promises to be similarly profound. The goal of the novel interdisciplinary field of Climate Informatics is to accelerate discovery in climate science with machine learning, in order to shed light on urgent questions about climate change. In this talk, I will survey my research group's progress in the emerging field of climate informatics. Our work includes algorithms to improve the combined predictions of the IPCC multi-model ensemble, applications to seasonal and subseasonal prediction, and a data-driven technique to detect and define extreme events.

  16. Advanced X-ray Astrophysics Facility (AXAF): Science working group report. [space shuttle payload

    NASA Technical Reports Server (NTRS)

    1980-01-01

    The Advanced X-Ray Astrophysics Facility (AXAF) mission concept is examined from a scientific viewpoint. A brief description of the development of X-ray astronomy and a summary description of AXAF, the scientific objectives of the facility, a description of representative scientific instruments, requirements for X-ray ground testing, and a summary of studies related to spacecraft and support subsystems, are included.

  17. Advanced superconducting technology for global science: The Large Hadron Collider at CERN

    NASA Astrophysics Data System (ADS)

    Lebrun, Ph.

    2002-05-01

    The Large Hadron Collider (LHC), presently in construction at CERN, the European Organization for Nuclear Research near Geneva (Switzerland), will be, upon its completion in 2005 and for the next twenty years, the most advanced research instrument of the world's high-energy physics community, providing access to the energy frontier above 1 TeV per elementary constituent. Re-using the 26.7-km circumference tunnel and infrastructure of the past LEP electron-positon collider, operated until 2000, the LHC will make use of advanced superconducting technology-high-field Nb-Ti superconducting magnets operated in superfluid helium and a cryogenic ultra-high vacuum system-to bring into collision intense beams of protons and ions at unprecedented values of center-of-mass energy and luminosity (14 TeV and 1034 cm-2ṡs-1, respectively with protons). After some ten years of focussed R&D, the LHC components are presently series-built in industry and procured through world-wide collaboration. After briefly recalling the physics goals, performance challenges and design choices of the machine, we describe its major technical systems, with particular emphasis on relevant advances in the key technologies of superconductivity and cryogenics, and report on its construction progress.

  18. Science.

    ERIC Educational Resources Information Center

    Roach, Linda E., Ed.

    This document contains the following papers on science instruction and technology: "A 3-D Journey in Space: A New Visual Cognitive Adventure" (Yoav Yair, Rachel Mintz, and Shai Litvak); "Using Collaborative Inquiry and Interactive Technologies in an Environmental Science Project for Middle School Teachers: A Description and Analysis" (Patricia…

  19. Organization and Implementation of a University-Wide Collaboration for Advancing Teaching Technology and Science in Public Schools

    NASA Astrophysics Data System (ADS)

    Regens, N.; Hall-Wallace, M. K.

    2003-12-01

    The University of Arizona's Collaboration for the Advancement of Teaching Technology and Science (CATTS) was formed 4 years ago for the purpose of teaming university graduate and undergraduate science students with local K-12 teachers to enhance science teaching at all grade levels. This NSF-funded GK-12 program has been remarkably successful at training university students to use exemplary science education materials and to enable them to work within the culture of K-12 classrooms. The program relies on the formation and maintainence of a respectful, robust, and mutually beneficial relationship between the university and Tucson area school districts, school principals, and schoolteachers. This paper explores the process we have used and are using to build and maintain a partnership between two very diverse cultures: the K-12 culture and the university's research-based culture. The CATTS program links University of Arizona outreach projects with schools, trains CATTS Fellows on current educational pedagogical thinking, and provides a means of evaluating the teaching effectiveness of CATTS Fellows. The presentation will describe the strategies and techniques for building and maintaining alliances and creating ownership of the CATTS programs by school districts, school administrators, and teachers. We will also describe recruiting and training practices and various corrective actions we have taken to improve the program over its lifetime. The CATTS program provides an effective outreach tool for educational programs in geophysics, marine biology and oceanography, climatology, hydrology, and space physics and astronomy, to name a few. As such it is an example of a core outreach program that can be used at research universities, national research facilities, or non-research oriented colleges. The program also provides an effective way to train future teaching professors and scientists to effectively participate in formal and informal education and public outreach

  20. Low-dose temozolomide before dendritic-cell vaccination reduces (specifically) CD4+CD25++Foxp3+ regulatory T-cells in advanced melanoma patients

    PubMed Central

    2013-01-01

    Background In cancer immunotherapy, dendritic cells (DCs) play a fundamental role in the dialog between innate and adaptive immune response, but several immunosuppressive mechanisms remain to be overcome. For example, a high number of CD4+CD25++Foxp3+ regulatory T-cells (Foxp3+Tregs) have been observed in the peripheral blood and tumor microenvironment of cancer patients. On the basis of this, we conducted a study on DC-based vaccination in advanced melanoma, adding low-dose temozolomide to obtain lymphodepletion. Methods Twenty-one patients were entered onto our vaccination protocol using autologous DCs pulsed with autologous tumor lysate and keyhole limpet hemocyanin. Patients received low-dose temozolomide before vaccination and 5 days of low-dose interleukin-2 (IL-2) after vaccination. Circulating Foxp3+Tregs were evaluated before and after temozolomide, and after IL-2. Results Among the 17 evaluable patients we observed 1 partial response (PR), 6 stable disease (SD) and 10 progressive disease (PD). The disease control rate (PR+SD = DCR) was 41% and median overall survival was 10 months. Temozolomide reduced circulating Foxp3+Treg cells in all patients. A statistically significant reduction of 60% was observed in Foxp3+Tregs after the first cycle, whereas the absolute lymphocyte count decreased by only 14%. Conversely, IL-2 increased Foxp3+Treg cell count by 75.4%. Of note the effect of this cytokine, albeit not statistically significant, on the DCR subgroup led to a further 33.8% reduction in Foxp3+Treg cells. Conclusions Our results suggest that the combined immunological therapy, at least as far as the DCR subgroup is concerned, effectively reduced the number of Foxp3+Treg cells, which exerted a blunting effect on the growth-stimulating effect of IL-2. However, this regimen, with its current modality, would not seem to be capable of improving clinical outcome. PMID:23725550

  1. An investigation into trends in Advanced Placement test taking in science and mathematics among student sub-populations using a longitudinal growth model

    NASA Astrophysics Data System (ADS)

    Campbell, D. Michael

    The lack of preparation, participation, and equal access of students in mathematics and the science education continues to afflict America's high school system (Ratliff, 2001). Additionally, gender and ethnic status have become significant factors as females and minority subgroups such as African Americans and Hispanics continue to be underrepresented in these two subject fields. Recognizing and understanding these trends is extremely important for the future of this country. As fewer minorities and females become involved in advanced mathematics and science curriculum there will be a continued lack of minorities and females in mathematics and science careers. Additionally, this insufficient representation leads to fewer numbers of females and minorities in industry and educational leadership positions in mathematics and science to promote participation and equality in these fields. According to Brainard and Carlin (2003) as trends currently stand, these two groups will be under-represented in the fields of math and science and will continue to be denied economic and social power. Thus, a better understanding of these trends in participation in mathematics and science among these groups of students is warranted. This study is intended to accomplish four objectives. The first objective is to identify the extent to which opportunities are increasing or decreasing for students in high schools taking mathematics and science Advanced Placement exams by examining six years of student testing data from the College Board. A second objective is to identify features of high schools that relate to greater expansion in Advanced Placement test taking for females and minority groups in the areas of both math and science. A third objective is to explore whether, and to what extent, any social or educational features such as economic status, regional school and living locations, and ethnic backgrounds have enhanced or reduced Advanced Placement testing in these schools. Lastly

  2. Strategies for Success of Women Faculty in Science: The ADVANCE Program at the University of Rhode Island

    NASA Astrophysics Data System (ADS)

    Wishner, K.; Silver, B.; Boudreaux-Bartels, F.; Harlow, L.; Knickle, H.; Mederer, H.; Peckham, J.; Roheim, C.; Trubatch, J.; Webster, K.

    2004-12-01

    The NSF-funded ADVANCE program seeks to increase the recruitment and retention of women faculty in science, technology, engineering, and mathematics (STEM) disciplines as part of a national goal of creating a broad-based scientific workforce able to effectively address societal demands. The University of Rhode Island, a recipient of an Institutional Transformation ADVANCE grant in 2003, has begun a campus-wide initiative. The 5 goals are (1) to increase the numbers of women STEM faculty, (2) to provide faculty development opportunities, (3) to improve networks of professional and social support, (4) to assess the academic work environment for all faculty, and (5) to implement long-term changes throughout the university that promote a supportive work environment for women STEM faculty. Accomplishments during the first year include (1) hiring several ADVANCE Assistant Professors, (2) developing workshops on critical skills for junior faculty (grant writing, negotiations, mentoring), (3) initiating a series of lunch meetings where pertinent topical and work-family issues are discussed informally, (4) awarding small Incentive grants for research and other projects that enhance the careers of women STEM faculty, (5) developing and modifying university policies on family leave and dual career couple recruitment, (6) developing and implementing quantitative and qualitative assessment tools for baseline and ongoing campus-wide work climate surveys within the context of a theoretical model for change, and (7) offering directed self-study workshops for entire departments using a trained facilitator. The ADVANCE Assistant Professor position, unique to URI's program, allows a new hire to spend the first 2-3 years developing a research program without teaching obligations. ADVANCE pays their salary during this time, at which point they transition to a regular faculty position. During this first of five years of NSF funding, the ADVANCE program has been met with campus wide

  3. University of Arizona's Collaboration to Advance Teaching Technology and Science (CATTS): lesson for photonics education collaborations

    NASA Astrophysics Data System (ADS)

    Hall-Wallace, Michelle; Regens, Nancy L.; Pompea, Stephen M.

    2002-05-01

    CATTS is a National Science Foundation-funded partnership between the University of Arizona and local school districts to improve science, mathematics and technology teaching at all levels. The goals of the CATTS Program are to develop sustainable partnerships with Kindergarten through 12th grade level (K-12) educators that foster integration of science, mathematics, engineering and technology research in classroom learning experiences. The program also creates opportunities for graduate and undergraduate students to be active participants in K-12 education by providing training and fellowships. CATTS seeks to foster effective teaching and a greater understanding of learning at all levels. School districts and University of Arizona outreach programs propose fellowship activities that address identified educational needs; they work together with CATTS to create customized programs to meet those needs. CATTS Fellows, their faculty mentors and K - 12 partners participate in workshops to gain experience with inquiry-based teaching and understanding diverse learning styles. In the partnership, CATTS Fellows have an opportunity to share their research experiences with K - 12 educators and gain experience with inquiry teaching. On the other side of the partnership, professional educators share their knowledge of teaching with Fellows and gain deeper understanding of scientific inquiry. In the two years that this NSF funded program has been in operation, a variety of lessons have been learned that can apply to school, university, and industrial partnerships to foster education and training. In particular since each organization operates in its own subculture, particular attention must be paid to raising cultural awareness among the participants in ways that foster mutual respect and communication of shared goals. Proper coordination and sensible logistics are also critical for the success of a complex project such as this. Training of the partners and the project

  4. Scale in Remote Sensing and GIS: An Advancement in Methods Towards a Science of Scale

    NASA Technical Reports Server (NTRS)

    Quattrochi, Dale A.

    1998-01-01

    The term "scale", both in space and time, is central to remote sensing and geographic information systems (GIS). The emergence and widespread use of GIS technologies, including remote sensing, has generated significant interest in addressing scale as a generic topic, and in the development and implementation of techniques for dealing explicitly with the vicissitudes of scale as a multidisciplinary issue. As science becomes more complex and utilizes databases that are capable of performing complex space-time data analyses, it becomes paramount that we develop the tools and techniques needed to operate at multiple scales, to work with data whose scales are not necessarily ideal, and to produce results that can be aggregated or disaggregated in ways that suit the decision-making process. Contemporary science is constantly coping with compromises, and the data available for a particular study rarely fit perfectly with the scales at which the processes being investigated operate, or the scales that policy-makers require to make sound, rational decisions. This presentation discusses some of the problems associated with scale as related to remote sensing and GIS, and describes some of the questions that need to be addressed in approaching the development of a multidisciplinary "science of scale". Techniques for dealing with multiple scaled data that have been developed or explored recently are described as a means for recognizing scale as a generic issue, along with associated theory and tools that can be of simultaneous value to a large number of disciplines. These can be used to seek answers to a host of interrelated questions in the interest of providing a formal structure for the management and manipulation of scale and its universality as a key concept from a multidisciplinary perspective.

  5. Scale in Remote Sensing and GIS: An Advancement in Methods Towards a Science of Scale

    NASA Technical Reports Server (NTRS)

    Quattrochi, D. A.

    1998-01-01

    The term "scale", both in space and time, is central to remote sensing and Geographic Information Systems (GIS). The emergence and widespread use of GIS technologies, including remote sensing, has generated significant interest in addressing scale as a generic topic, and in the development and implementation of techniques for dealing explicitly with the vicissitudes of scale as a multidisciplinary issue. As science becomes more complex and utilizes databases that are capable of performing complex space-time data analyses, it becomes paramount that we develop the tools and techniques needed to operate at multiple scales, to work with data whose scales are not necessarily ideal, and to produce results that can be aggregated or disaggregated ways that suit the decision-making process. Contemporary science is constantly coping with compromises, and the data available for a particular study rarely fit perfectly with the scales at which the processes being investigated operate, or the scales that policy-makers require to make sound, rational decisions. This presentation discusses some of the problems associated with scale as related to remote sensing and GIS, and describes some of the questions that need to be addressed in approaching the development of a multidisciplinary "science of scale". Techniques for dealing with multiple scaled data that have been developed or explored recently are described as a means for recognizing scale as a generic issue, along with associated theory and tools that can be of simultaneous value to a large number of disciplines. These can be used to seek answers to a host of interrelated questions in the interest of providing a formal structure for the management and manipulation of scale and its universality as a key concept from a multidisciplinary perspective.

  6. a Roadmap to Advance Understanding of the Science of Space Weather

    NASA Astrophysics Data System (ADS)

    Schrijver, K.; Kauristie, K.; Aylward, A.; De Nardin, C. M.; Gibson, S. E.; Glover, A.; Gopalswamy, N.; Grande, M.; Hapgood, M. A.; Heynderickx, D.; Jakowski, N.; Kalegaev, V. V.; Lapenta, G.; Linker, J.; Liu, S.; Mandrini, C. H.; Mann, I. R.; Nagatsuma, T.; Nandy, D.; Obara, T.; O'Brien, T. P., III; Onsager, T. G.; Opgenoorth, H. J.; Terkildsen, M. B.; Valladares, C. E.; Vilmer, N.

    2015-12-01

    There is a growing appreciation that the environmental conditions that we call space weather impact the technological infrastructure that powers the coupled economies around the world. With that comes the need to better shield society against space weather by improving forecasts, environmental specifications, and infrastructure design. A COSPAR/ILWS team recently completed a roadmap that identifies the scientific focus areas and research infrastructure that are needed to significantly advance our understanding of space weather of all intensities and of its implications and costs for society. This presentation provides a summary of the highest-priority recommendations from that roadmap.

  7. The advanced light source: America`s brightest light for science and industry

    SciTech Connect

    Cross, J.; Lawler, G.

    1994-03-01

    America`s brightest light comes from the Advanced Light Source (ALS), a national facility for scientific research, product development, and manufacturing. Completed in 1993, the ALS produces light in the ultraviolet and x-ray regions of the spectrum. Its extreme brightness provides opportunities for scientific and technical progress not possible anywhere else. Technology is poised on the brink of a major revolution - one in which vital machine components and industrial processes will be drastically miniaturized. Industrialized nations are vying for leadership in this revolution - and the huge economic rewards the leaders will reap.

  8. An Advanced Educational Program for Software Design Engineering at Graduate School of Information Science and Technology of Osaka University

    NASA Astrophysics Data System (ADS)

    Masuzawa, Toshimitsu; Inoue, Katsuro; Murakami, Koso; Fujiwara, Toru; Nishio, Shojiro

    This paper gives an overview of an advanced educational program for software design engineering that is currently conducted at Graduate School of Information Science and Technology, Osaka University under the grant “ Initiatives for Attractive Education in Graduate Schools” from MEXT. Software design engineering is highly expected to play a critical role in winning success in designing the next-generation software systems. The aim of the program is to bring up young researchers with the latest design methodologies and practical design experience, who can pioneer the frontier of software design engineering. The program is conducted with the collaboration of industries that have rich practical experience and are facing the engineering problems to be solved in developing the next-generation software.

  9. Mutually responsive orientation between parents and their young children: toward methodological advances in the science of relationships.

    PubMed

    Aksan, Nazan; Kochanska, Grazyna; Ortmann, Margaret R

    2006-09-01

    The authors captured mother-child and father-child relationships when children were 7 and 15 months old by coding 4 explicitly dyadic components of mutually responsive orientation (MRO): coordinated routines, harmonious communication, mutual cooperation, and emotional ambiance. These components were coded in 102 families in naturalistic contexts at home and in the laboratory. Using confirmatory factor analytic methods, the authors demonstrated that MRO (a) is a unidimensional latent construct, (b) can be distinguished from and is not reducible to the 2 interacting individuals' qualities (responsiveness and positive affect), and (c) has remarkable measurement equivalence from ages 7 to 15 months for both mother-child and father-child relationships and has remarkable measurement equivalence across both parent-child relationships at both child ages. This study represents an effort to advance the science of relationships by moving away from individual-based measures to dyadic measures and by using contemporary data analytic strategies. PMID:16953690

  10. The Advanced Technology Large Aperture Space Telescope (ATLAST): Science Drivers, Technology Developments, and Synergies with Other Future Facilities

    NASA Technical Reports Server (NTRS)

    Postman, Marc; Brown, Tom; Sembach, Kenneth; Giavalisco, Mauro; Traub, Wesley; Stapelfeldt, Karl; Calzetti, Daniela; Oegerle, William; Rich, R. Michael; Stahl, H. Philip; Tumlinson, Jason; Mountain, Matt; Soummer, Remi; Hyde, Tupper

    2011-01-01

    The Advanced Technology Large-Aperture Space Telescope (ATLAST) is a concept for an 8-meter to 16-meter UVOIR space observatory for launch in the 2025-2030 era. ATLAST will allow astronomers to answer fundamental questions at the forefront of modern astrophysics, including "Is there life elsewhere in the Galaxy?" We present a range of science drivers that define the main performance requirements for ATLAST (8 to 16 milliarcsec angular resolution, diffraction limited imaging at 0.5 m wavelength, minimum collecting area of 45 square meters, high sensitivity to light wavelengths from 0.1 m to 2.4 m, high stability in wavefront sensing and control). We will also discuss the synergy between ATLAST and other anticipated future facilities (e.g., TMT, EELT, ALMA) and the priorities for technology development that will enable the construction for a cost that is comparable to current generation observatory-class space missions.

  11. Soft X-Ray Microscopy and Spectroscopy at the Molecular Environmental Science Beamline at the Advanced Light Source

    SciTech Connect

    Bluhm, Hendrik; Andersson, Klas J.; Araki, Tohru; Benzerara, Karim; Brown, Gordon E.; Dynes, Jay J.; Ghosal, Sutapa; Gilles, Mary K.; Hansen, Hans C.; Hemminger, J. C.; Hitchcock, Adam P.; Ketteler, Guido; Kilcoyne, Arthur L.; Kneedler, Eric M.; Lawrence, John R.; Leppard, Gary G.; Majzlam, Juraj; Mun, B. S.; Myneni, Satish C.; Nilsson, Anders R.; Ogasawara, Hirohito; Ogletree, D. F.; Pecher, Klaus H.; Salmeron, Miquel B.; Shuh, David K.; Tonner, Brian; Tyliszczak, Tolek; Warwick, Tony; Yoon, T. H.

    2006-02-01

    We present examples of the application of synchrotron-based spectroscopies and microscopies to environmentally-relevant samples. The experiments were performed at the Molecular Environmental Science beamline (11.0.2) at the Advanced Light Source, Lawrence Berkeley National Laboratory. Examples range from the study of water monolayers on Pt(111) single crystal surfaces using X-ray emission spectroscopy and the examination of alkali halide solution/water vapor interfaces using ambient pressure photoemission spectroscopy, to the investigation of actinides, river-water biofilms, Al-containing colloids and mineral-bacteria suspensions using scanning transmission X-ray spectromicroscopy. The results of our experiments show that spectroscopy and microscopy in the soft X-ray energy range are excellent tools for the investigation of environmentally relevant samples under realistic conditions, i.e. with water or water vapor present at ambient temperature.

  12. CONTEXT AND THE ADVANCEMENT OF A GLOBAL SCIENCE OF HUMAN DEVELOPMENT: A COMMENTARY.

    PubMed

    Marfo, Kofi

    2016-03-01

    United Nations agencies mandated to address the needs of children around the developing (Majority) world, routinely create large global data sets mostly for purposes of surveillance and strategic planning of development aid. UNICEF's Multiple Indicator Cluster Surveys (MICS) have produced one of the largest sources of internationally comparable data on women and children. This monograph creatively and elegantly harnesses MICS data on 41 low- and middle-income countries to shed light on risk and protective factors associated with growing up a boy or girl in the developing world. In this commentary, I assess the monograph's contribution to the progress that our field must make toward greater geo-ecological and cultural inclusiveness of its knowledge base. I do so in the context of scholarship that is increasingly and justifiably questioning the relevance of mainstream developmental science outside the Euro-American world. I conclude that notwithstanding the limitations inherent in the data set, Bornstein, Putnick, Lansford, Deater-Deckard, and Bradley have done our field a great service by moving us further on a trajectory toward a more global science. PMID:27035454

  13. Polar marine biology science in Portugal and Spain: Recent advances and future perspectives

    NASA Astrophysics Data System (ADS)

    Xavier, José C.; Barbosa, Andrés; Agustí, Susana; Alonso-Sáez, Laura; Alvito, Pedro; Ameneiro, Julia; Ávila, Conxita; Baeta, Alexandra; Canário, João; Carmona, Raquel; Catry, Paulo; Ceia, Filipe; Clark, Melody S.; Cristobo, Francisco J.; Cruz, Bruno; Duarte, Carlos M.; Figuerola, Blanca; Gili, Josep-Maria; Gonçalves, Ana R.; Gordillo, Francisco J. L.; Granadeiro, José P.; Guerreiro, Miguel; Isla, Enrique; Jiménez, Carlos; López-González, Pablo J.; Lourenço, Sílvia; Marques, João C.; Moreira, Elena; Mota, Ana M.; Nogueira, Marta; Núñez-Pons, Laura; Orejas, Covadonga; Paiva, Vitor H.; Palanques, Albert; Pearson, Gareth A.; Pedrós-Alió, Carlos; Peña Cantero, Álvaro L.; Power, Deborah M.; Ramos, Jaime A.; Rossi, Sergi; Seco, José; Sañé, Elisabet; Serrão, Ester A.; Taboada, Sergi; Tavares, Sílvia; Teixidó, Núria; Vaqué, Dolors; Valente, Tiago; Vázquez, Elsa; Vieira, Rui P.; Viñegla, Benjamin

    2013-10-01

    Polar marine ecosystems have global ecological and economic importance because of their unique biodiversity and their major role in climate processes and commercial fisheries, among others. Portugal and Spain have been highly active in a wide range of disciplines in marine biology of the Antarctic and the Arctic. The main aim of this paper is to provide a synopsis of some of the results and initiatives undertaken by Portuguese and Spanish polar teams within the field of marine sciences, particularly on benthic and pelagic biodiversity (species diversity and abundance, including microbial, molecular, physiological and chemical mechanisms in polar organisms), conservation and ecology of top predators (particularly penguins, albatrosses and seals), and pollutants and evolution of marine organisms associated with major issues such as climate change, ocean acidification and UV radiation effects. Both countries have focused their polar research more in the Antarctic than in the Arctic. Portugal and Spain should encourage research groups to continue increasing their collaborations with other countries and develop multi-disciplinary research projects, as well as to maintain highly active memberships within major organizations, such as the Scientific Committee for Antarctic Research (SCAR), the International Arctic Science Council (IASC) and the Association of Polar Early Career Scientists (APECS), and in international research projects.

  14. Advancing Weather and Climate Literacy via NOAA Science On a Sphere Exhibits

    NASA Astrophysics Data System (ADS)

    Rowley, P.; Pisut, D.; Ackerman, S. A.; Mooney, M. E.; Schollaert Uz, S.

    2013-12-01

    The EarthNow project (http://sphere.ssec.wisc.edu/) regularly creates weather and climate visualizations for spherical display exhibits, like Science On a Sphere (SOS), using near real-time data such as NOAA's National Climate Data Center's (NCDC) monthly climate reports and the Climate Prediction Center's (CPC) seasonal outlooks. Viewing timely weather and climate stories on a large sphere-format allows museum visitors to more intuitively learn about global-scale earth system science. Along with producing large animations for SOS exhibits with background content, the EarthNow team also visits SOS museums (there are now over 100 SOS sites around the world) to conduct best-practice trainings and consultancies. These training sessions provide museums with implementation methods tailored to each museum's goals, allowing for a more personalized learning experience for museum visitors. This presentation will convey evaluation and feedback results from these training sites. The EarthNow project is led by the Cooperative Institute for Meteorological Satellite Studies (CIMSS), in collaboration with the Cooperative Institute for Climate and Satellites (CICS-MD) and the NOAA Environmental Visualization Lab.

  15. Toward a Psychological Science of Advanced Technology Design for Older Adults

    PubMed Central

    Fisk, Arthur D.

    2010-01-01

    Objectives. Technology represents advances in knowledge that change the way humans perform tasks. Ideally, technology will make the task easier, more efficient, safer, or perhaps more pleasurable. Unfortunately, new technologies can sometimes make a task more difficult, slower, dangerous, or perhaps more frustrating. Older adults interact with a variety of technologies in the course of their daily activities and thus products should be designed to be used by people of varying ages. Methods. In this article, we provide an overview of what psychology has to offer to the design of technology—from understanding what people need, to identifying their preferences for design characteristics, and to defining their capabilities and limitations that will influence technology interactions. Results. We identify how research in the field of psychology and aging has advanced understanding of technology interactions and how research on technology interactions can inform theories of aging. Discussion. Design for aging involves understanding the unique capabilities and limitations of older adults; identifying their needs, preferences, and desires for technology in their lives; and involving them in the design process. PMID:20833690

  16. PREFACE: International Conference on Advancement in Science and Technology 2012 (iCAST): Contemporary Mathematics, Mathematical Physics and their Applications

    NASA Astrophysics Data System (ADS)

    Ganikhodjaev, Nasir; Mukhamedov, Farrukh; Hee, Pah Chin

    2013-04-01

    The 4th International Conference on the Advancement of Science and Technology 2012 (iCAST 2012), with theme 'Contemporary Mathematics, Mathematical Physics and their Applications', took place in Kuantan, Malaysia, from Wednesday 7 to Friday 9 November 2012. The conference was attended by more than 100 participants, and hosted about 160 oral and poster papers by more than 140 pre-registered authors. The key topics of the 4th iCAST 2012 include Pure Mathematics, Applied Mathematics, Theoretical/Mathematical Physics, Dynamical Systems, Statistics and Financial Mathematics. The scientific program was rather full since after the Keynote and Invited Talks in the morning, four parallel sessions ran every day. However, according to all attendees, the program was excellent with a high level of talks and the scientific environment was fruitful; thus all attendees had a creative time. The conference aimed to promote the knowledge and development of high-quality research in mathematical fields concerned with the application of other scientific fields as well as modern technological trends in physics, chemistry, biology, medicine, economics, sociology and environmental sciences. We would like to thank the Keynote and the Invited Speakers for their significant contributions to 4th iCAST 2012. We would also like to thank the members of the International Scientific Committee and the members of the Organizing Committee. We cannot end without expressing our many thanks to International Islamic University Malaysia and our sponsors for their financial support . This volume presents selected papers which have been peer-reviewed. The editors hope that it may be useful and fruitful for scholars, researchers, and advanced technical members of the industrial laboratory facilities for developing new tools and products. Guest Editors Nasir Ganikhodjaev, Farrukh Mukhamedov and Pah Chin Hee The PDF contains the committee lists, board list and biographies of the plenary speakers.

  17. What’s Needed from Climate Modeling to Advance Actionable Science for Water Utilities?

    NASA Astrophysics Data System (ADS)

    Barsugli, J. J.; Anderson, C. J.; Smith, J. B.; Vogel, J. M.

    2009-12-01

    “…perfect information on climate change is neither available today nor likely to be available in the future, but … over time, as the threats climate change poses to our systems grow more real, predicting those effects with greater certainty is non-discretionary. We’re not yet at a level at which climate change projections can drive climate change adaptation.” (Testimony of WUCA Staff Chair David Behar to the House Committee on Science and Technology, May 5, 2009) To respond to this challenge, the Water Utility Climate Alliance (WUCA) has sponsored a white paper titled “Options for Improving Climate Modeling to Assist Water Utility Planning for Climate Change. ” This report concerns how investments in the science of climate change, and in particular climate modeling and downscaling, can best be directed to help make climate projections more actionable. The meaning of “model improvement” can be very different depending on whether one is talking to a climate model developer or to a water manager trying to incorporate climate projections in to planning. We first surveyed the WUCA members on present and potential uses of climate model projections and on climate inputs to their various system models. Based on those surveys and on subsequent discussions, we identified four dimensions along which improvement in modeling would make the science more “actionable”: improved model agreement on change in key parameters; narrowing the range of model projections; providing projections at spatial and temporal scales that match water utilities system models; providing projections that water utility planning horizons. With these goals in mind we developed four options for improving global-scale climate modeling and three options for improving downscaling that will be discussed. However, there does not seem to be a single investment - the proverbial “magic bullet” -- which will substantially reduce the range of model projections at the scales at which utility

  18. DOE Response to the Fukushima Accident: Advancing the Science of Emergency Response

    NASA Astrophysics Data System (ADS)

    Blumenthal, Daniel

    2015-04-01

    The US Department of Energy maintains specialized technical teams to respond to radiological/nuclear emergencies. They apply well-established laboratory nuclear measurement techniques in field environments, conduct rapid analysis, and deliver data products to government leaders in support of real-time public safety decisions. Meeting these requirements, often in the face of incomplete and imperfect information, takes a great deal of training and practice to effectively translate science into operations. Since large-scale emergencies are rare, the Fukushima nuclear accident in March 2011 provided an opportunity to employ these teams. Their timely support to both US and Japanese decision makers provides an excellent case study in the application of instrumentation, analysis methods, data presentation, and training to emergency response.

  19. More Than Pretty Pictures: How Translating Science Concepts into Pictures Advances Scientific Thinking

    NASA Astrophysics Data System (ADS)

    Frankel, Felice

    2010-02-01

    The judgment and decision-making required to render science visual clarifies thinking. One must decide on a hierarchy of information--what must be included and what might be left out? What is the main point of the visual? Just as in writing an article or responding to an essay question, we must understand and then plan what we want to ``say'' in a drawing or other forms of representation. And since a visual representation of a scientific concept (or data) is a re-presentation, and not the thing itself, interpretation or translation is involved. The process tends to transcend barriers of linguistic facility and educational background; it attracts and communicates students and teachers of all backgrounds, where other methods intimidate. The rendered images are, in essence More Than Pretty Pictures. )

  20. Advances in earthquake and tsunami sciences and disaster risk reduction since the 2004 Indian ocean tsunami

    NASA Astrophysics Data System (ADS)

    Satake, Kenji

    2014-12-01

    The December 2004 Indian Ocean tsunami was the worst tsunami disaster in the world's history with more than 200,000 casualties. This disaster was attributed to giant size (magnitude M ~ 9, source length >1000 km) of the earthquake, lacks of expectation of such an earthquake, tsunami warning system, knowledge and preparedness for tsunamis in the Indian Ocean countries. In the last ten years, seismology and tsunami sciences as well as tsunami disaster risk reduction have significantly developed. Progress in seismology includes implementation of earthquake early warning, real-time estimation of earthquake source parameters and tsunami potential, paleoseismological studies on past earthquakes and tsunamis, studies of probable maximum size, recurrence variability, and long-term forecast of large earthquakes in subduction zones. Progress in tsunami science includes accurate modeling of tsunami source such as contribution of horizontal components or "tsunami earthquakes", development of new types of offshore and deep ocean tsunami observation systems such as GPS buoys or bottom pressure gauges, deployments of DART gauges in the Pacific and other oceans, improvements in tsunami propagation modeling, and real-time inversion or data assimilation for the tsunami warning. These developments have been utilized for tsunami disaster reduction in the forms of tsunami early warning systems, tsunami hazard maps, and probabilistic tsunami hazard assessments. Some of the above scientific developments helped to reveal the source characteristics of the 2011 Tohoku earthquake, which caused devastating tsunami damage in Japan and Fukushima Dai-ichi Nuclear Power Station accident. Toward tsunami disaster risk reduction, interdisciplinary and trans-disciplinary approaches are needed for scientists with other stakeholders.

  1. Advanced photoelectric effect experiment beamline at Elettra: A surface science laboratory coupled with Synchrotron Radiation

    SciTech Connect

    Panaccione, G.; Vobornik, I.; Fujii, J.; Krizmancic, D.; Annese, E.; Giovanelli, L.; Maccherozzi, F.; Salvador, F.; De Luisa, A.; Benedetti, D.; Gruden, A.; Bertoch, P.; Rossi, G.; Polack, F.; Cocco, D.; Sostero, G.; Diviacco, B.; Hochstrasser, M.; Maier, U.; Pescia, D.; and others

    2009-04-15

    We report the main characteristics of the advanced photoelectric effect experiments beamline, operational at Elettra storage ring, featuring a fully independent double branch scheme obtained by the use of chicane undulators and able to keep polarization control in both linear and circular mode. The paper describes the novel technical solutions adopted, namely, (a) the design of a quasiperiodic undulator resulting in optimized suppression of higher harmonics over a large photon energy range (10-100 eV), (b) the thermal stability of optics under high heat load via cryocoolers, and (c) the end station interconnected setup allowing full access to off-beam and on-beam facilities and, at the same time, the integration of users' specialized sample growth chambers or modules.

  2. Mission science value-cost savings from the Advanced Imaging Communication System (AICS)

    NASA Technical Reports Server (NTRS)

    Rice, R. F.

    1984-01-01

    An Advanced Imaging Communication System (AICS) was proposed in the mid-1970s as an alternative to the Voyager data/communication system architecture. The AICS achieved virtually error free communication with little loss in the downlink data rate by concatenating a powerful Reed-Solomon block code with the Voyager convolutionally coded, Viterbi decoded downlink channel. The clean channel allowed AICS sophisticated adaptive data compression techniques. Both Voyager and the Galileo mission have implemented AICS components, and the concatenated channel itself is heading for international standardization. An analysis that assigns a dollar value/cost savings to AICS mission performance gains is presented. A conservative value or savings of $3 million for Voyager, $4.5 million for Galileo, and as much as $7 to 9.5 million per mission for future projects such as the proposed Mariner Mar 2 series is shown.

  3. Advanced data visualization and sensor fusion: Conversion of techniques from medical imaging to Earth science

    NASA Technical Reports Server (NTRS)

    Savage, Richard C.; Chen, Chin-Tu; Pelizzari, Charles; Ramanathan, Veerabhadran

    1993-01-01

    Hughes Aircraft Company and the University of Chicago propose to transfer existing medical imaging registration algorithms to the area of multi-sensor data fusion. The University of Chicago's algorithms have been successfully demonstrated to provide pixel by pixel comparison capability for medical sensors with different characteristics. The research will attempt to fuse GOES (Geostationary Operational Environmental Satellite), AVHRR (Advanced Very High Resolution Radiometer), and SSM/I (Special Sensor Microwave Imager) sensor data which will benefit a wide range of researchers. The algorithms will utilize data visualization and algorithm development tools created by Hughes in its EOSDIS (Earth Observation SystemData/Information System) prototyping. This will maximize the work on the fusion algorithms since support software (e.g. input/output routines) will already exist. The research will produce a portable software library with documentation for use by other researchers.

  4. Mesoscale Science with High Energy X-ray Diffraction Microscopy at the Advanced Photon Source

    NASA Astrophysics Data System (ADS)

    Suter, Robert

    2014-03-01

    Spatially resolved diffraction of monochromatic high energy (> 50 keV) x-rays is used to map microstructural quantities inside of bulk polycrystalline materials. The non-destructive nature of High Energy Diffraction Microscopy (HEDM) measurements allows tracking of responses as samples undergo thermo-mechanical or other treatments. Volumes of the order of a cubic millimeter are probed with micron scale spatial resolution. Data sets allow direct comparisons to computational models of responses that frequently involve long-ranged, multi-grain interactions; such direct comparisons have only become possible with the development of HEDM and other high energy x-ray methods. Near-field measurements map the crystallographic orientation field within and between grains using a computational reconstruction method that simulates the experimental geometry and matches orientations in micron sized volume elements to experimental data containing projected grain images in large numbers of Bragg peaks. Far-field measurements yield elastic strain tensors through indexing schemes that sort observed diffraction peaks into sets associated with individual crystals and detect small radial motions in large numbers of such peaks. Combined measurements, facilitated by a new end station hutch at Advanced Photon Source beamline 1-ID, are mutually beneficial and result in accelerated data reduction. Further, absorption tomography yields density contrast that locates secondary phases, void clusters, and cracks, and tracks sample shape during deformation. A collaboration led by the Air Force Research Laboratory and including the Advanced Photon Source, Lawrence Livermore National Laboratory, Carnegie Mellon University, Petra-III, and Cornell University and CHESS is developing software and hardware for combined measurements. Examples of these capabilities include tracking of grain boundary migrations during thermal annealing, tensile deformation of zirconium, and combined measurements of nickel

  5. Understanding what the public know and value about geoheritage sites in order to advance Earth science literacy

    NASA Astrophysics Data System (ADS)

    Vye, E. C.; Rose, W. I.

    2013-12-01

    With its impressive geology and rich cultural history, Michigan's Keweenaw Peninsula is ideally suited for Earth science education and geotourism initiatives, such as a Geopark. Geologic events that have shaped this region can be interpreted in such a way as to engage learners, not only through an intellectual connection to Earth science subject matter, but also through an emotional connection via culture, history, and sense of place. The notion that landscape is special because it is the sum total of all the interacting earth systems, including people as part of the biosphere, can be used to drive these initiatives as they affect one personally. It is speculated that most people in the Keweenaw have a basic understanding of the local cultural history and some understanding of geology. Advanced awareness and understanding of the geological significance of the Keweenaw stands to greatly enrich our community's sense of place and desire to advance further education and geotourism initiatives. It is anticipated that these initiatives will ultimately lead to increased Earth science literacy and understanding and recognition of one's own environs. This will aid in the further development of publications, teaching media, trails info, on-site museums, etc. Although the community has embraced geo-outreach thus far, it is germane to know what people value, what they know of the geology and how they connect to place. Results from semi-structured interviews administered with the aim and focus of determining what places are special to people, why they are special and how they formed will be presented in this paper. The results from this research will be used to direct the creation and continued development of geologic interpretation of our region. It is hoped that this understanding will reveal common misconceptions that can be used to improve interpretive material that not only addresses misconceptions but also connects the immediate past with the deep geologic past of the

  6. Animal board invited review: advances in proteomics for animal and food sciences.

    PubMed

    Almeida, A M; Bassols, A; Bendixen, E; Bhide, M; Ceciliani, F; Cristobal, S; Eckersall, P D; Hollung, K; Lisacek, F; Mazzucchelli, G; McLaughlin, M; Miller, I; Nally, J E; Plowman, J; Renaut, J; Rodrigues, P; Roncada, P; Staric, J; Turk, R

    2015-01-01

    Animal production and health (APH) is an important sector in the world economy, representing a large proportion of the budget of all member states in the European Union and in other continents. APH is a highly competitive sector with a strong emphasis on innovation and, albeit with country to country variations, on scientific research. Proteomics (the study of all proteins present in a given tissue or fluid - i.e. the proteome) has an enormous potential when applied to APH. Nevertheless, for a variety of reasons and in contrast to disciplines such as plant sciences or human biomedicine, such potential is only now being tapped. To counter such limited usage, 6 years ago we created a consortium dedicated to the applications of Proteomics to APH, specifically in the form of a Cooperation in Science and Technology (COST) Action, termed FA1002--Proteomics in Farm Animals: www.cost-faproteomics.org. In 4 years, the consortium quickly enlarged to a total of 31 countries in Europe, as well as Israel, Argentina, Australia and New Zealand. This article has a triple purpose. First, we aim to provide clear examples on the applications and benefits of the use of proteomics in all aspects related to APH. Second, we provide insights and possibilities on the new trends and objectives for APH proteomics applications and technologies for the years to come. Finally, we provide an overview and balance of the major activities and accomplishments of the COST Action on Farm Animal Proteomics. These include activities such as the organization of seminars, workshops and major scientific conferences, organization of summer schools, financing Short-Term Scientific Missions (STSMs) and the generation of scientific literature. Overall, the Action has attained all of the proposed objectives and has made considerable difference by putting proteomics on the global map for animal and veterinary researchers in general and by contributing significantly to reduce the East-West and North-South gaps

  7. REGULATORY AIR QUALITY MODELS

    EPA Science Inventory

    Appendix W to 40CFR Part 51 (Guideline on Air Quality Models) specifies the models to be used for purposes of permitting, PSD, and SIPs. Through a formal regulatory process this modeling guidance is periodically updated to reflect current science. In the most recent action, thr...

  8. The GMOS cyber(e)-infrastructure: advanced services for supporting science and policy.

    PubMed

    Cinnirella, S; D'Amore, F; Bencardino, M; Sprovieri, F; Pirrone, N

    2014-03-01

    The need for coordinated, systematized and catalogued databases on mercury in the environment is of paramount importance as improved information can help the assessment of the effectiveness of measures established to phase out and ban mercury. Long-term monitoring sites have been established in a number of regions and countries for the measurement of mercury in ambient air and wet deposition. Long term measurements of mercury concentration in biota also produced a huge amount of information, but such initiatives are far from being within a global, systematic and interoperable approach. To address these weaknesses the on-going Global Mercury Observation System (GMOS) project ( www.gmos.eu ) established a coordinated global observation system for mercury as well it retrieved historical data ( www.gmos.eu/sdi ). To manage such large amount of information a technological infrastructure was planned. This high-performance back-end resource associated with sophisticated client applications enables data storage, computing services, telecommunications networks and all services necessary to support the activity. This paper reports the architecture definition of the GMOS Cyber(e)-Infrastructure and the services developed to support science and policy, including the United Nation Environmental Program. It finally describes new possibilities in data analysis and data management through client applications. PMID:24249682

  9. Innovative Graduate Research Education for Advancement of Implementation Science in Adolescent Behavioral Health.

    PubMed

    Burton, Donna L; Levin, Bruce Lubotsky; Massey, Tom; Baldwin, Julie; Williamson, Heather

    2016-04-01

    An innovative approach to research education that integrates the theory and principles of implementation science, participatory research, and service learning in the area of adolescent behavioral health is presented. Qualitative interviews and surveys of program participants have been conducted to assess the program's curricula, service-learning partnerships, student (scholar) satisfaction, and views of community partnerships and academic mentors. The Institute has experienced the successful completion of its first and second cohorts and enrollment of a third cohort of scholars. Community partners are utilizing results of service-learning projects to influence agency operations. Institute scholars have identified research and service learning experiences as key factors in the decision to apply to the Institute graduate certificate program. The availability of tuition support is identified as valuable but not ranked as the most important reason for scholar interest in the program. Academic mentors report positive relationships with community agencies. Future iterations of the program will expand options for distance learning and alternatives to traditional graduate education for community-based scholars. Community partner agency capacity for participation is expected to change over time. Methods are being identified to both sustain existing partnerships and develop new community partnership relationships. PMID:26746638

  10. Physiological ecology in the 21st century: advancements in biologging science.

    PubMed

    Block, Barbara A

    2005-04-01

    Top pelagic predators such as tunas, sharks, marine turtles and mammals have historically been difficult to study due to their large body size and vast range over the oceanic habitat. In recent years the development of small microprocessor-based data storage tags that are surgically implanted or satellite-linked provide marine researchers a novel avenue for examining the movements, physiology and behaviors of pelagic animals in the wild. When biological and physical data obtained from the tags are combined with satellite derived sea surface temperature and ocean color data, the relationships between the movements, behaviors and physical ocean environment can be examined. Tag-bearing marine animals can function as autonomous ocean profilers providing oceanographic data wherever their long migrations take them. The biologging science is providing ecological physiologists with new insights into the seasonal movements, habitat utilization, breeding behaviors and population structures in of marine vertebrates. In addition, the data are revealing migration corridors, hot spots and physical oceanographic patterns that are key to understanding how organisms such as bluefin tunas use the open ocean environment. In the 21st century as ecosystem degradation and global warming continue to threaten the existence of species on Earth, the field of physiological ecology will play a more pivotal role in conservation biology. PMID:21676774

  11. Advanced Digitization Techniques in Retrieval of Mechanism and Machine Science Resources

    NASA Astrophysics Data System (ADS)

    Lovasz, E.-Ch.; Gruescu, C. M.; Ciupe, V.; Carabas, I.; Margineanu, D.; Maniu, I.; Dehelean, N.

    The European project thinkMOTION works on the purpose of retrieving all-times content regarding mechanisms and machine science by means of creating a digital library, accessible to a broad public through the portal Europeana. DMG-Lib is intended to display the development in the field, from its very beginning up to now days. There is a large range of significant objects available, physically very heterogeneous and needing all to be digitized. The paper presents the workflow, the equipments and specific techniques used in digitization of documents featuring very different characteristics (size, texture, color, degree of preservation, resolution and so on). Once the workflow established on very detailed steps, the development of the workstation is treated. Special equipments designed and assembled at Universitatea "Politehnica" Timisoara are presented. A large series of software applications, including original programs, work for digitization itself, processing of images, management of files, automatic optoelectronic control of capture, storage of information in different stages of processing. An illustrating example is explained, showing the steps followed in order to obtain a clear, high-resolution image from an old original document (very valuable as a historical proof but very poor in quality regarding clarity, contrast and resolution).

  12. JPL's Role in Advancing Earth System Science to Meet the Challenges of Climate and Environmental Change

    NASA Technical Reports Server (NTRS)

    Evans, Diane

    2012-01-01

    Objective 2.1.1: Improve understanding of and improve the predictive capability for changes in the ozone layer, climate forcing, and air quality associated with changes in atmospheric composition. Objective 2.1.2: Enable improved predictive capability for weather and extreme weather events. Objective 2.1.3: Quantify, understand, and predict changes in Earth s ecosystems and biogeochemical cycles, including the global carbon cycle, land cover, and biodiversity. Objective 2.1.4: Quantify the key reservoirs and fluxes in the global water cycle and assess water cycle change and water quality. Objective 2.1.5: Improve understanding of the roles of the ocean, atmosphere, land and ice in the climate system and improve predictive capability for its future evolution. Objective 2.1.6: Characterize the dynamics of Earth s surface and interior and form the scientific basis for the assessment and mitigation of natural hazards and response to rare and extreme events. Objective 2.1.7: Enable the broad use of Earth system science observations and results in decision-making activities for societal benefits.

  13. The Materials Data Facility: Data Services to Advance Materials Science Research

    NASA Astrophysics Data System (ADS)

    Blaiszik, B.; Chard, K.; Pruyne, J.; Ananthakrishnan, R.; Tuecke, S.; Foster, I.

    2016-07-01

    With increasingly strict data management requirements from funding agencies and institutions, expanding focus on the challenges of research replicability, and growing data sizes and heterogeneity, new data needs are emerging in the materials community. The materials data facility (MDF) operates two cloud-hosted services, data publication and data discovery, with features to promote open data sharing, self-service data publication and curation, and encourage data reuse, layered with powerful data discovery tools. The data publication service simplifies the process of copying data to a secure storage location, assigning data a citable persistent identifier, and recording custom (e.g., material, technique, or instrument specific) and automatically-extracted metadata in a registry while the data discovery service will provide advanced search capabilities (e.g., faceting, free text range querying, and full text search) against the registered data and metadata. The MDF services empower individual researchers, research projects, and institutions to (I) publish research datasets, regardless of size, from local storage, institutional data stores, or cloud storage, without involvement of third-party publishers; (II) build, share, and enforce extensible domain-specific custom metadata schemas; (III) interact with published data and metadata via representational state transfer (REST) application program interfaces (APIs) to facilitate automation, analysis, and feedback; and (IV) access a data discovery model that allows researchers to search, interrogate, and eventually build on existing published data. We describe MDF's design, current status, and future plans.

  14. Successful aging: Advancing the science of physical independence in older adults.

    PubMed

    Anton, Stephen D; Woods, Adam J; Ashizawa, Tetso; Barb, Diana; Buford, Thomas W; Carter, Christy S; Clark, David J; Cohen, Ronald A; Corbett, Duane B; Cruz-Almeida, Yenisel; Dotson, Vonetta; Ebner, Natalie; Efron, Philip A; Fillingim, Roger B; Foster, Thomas C; Gundermann, David M; Joseph, Anna-Maria; Karabetian, Christy; Leeuwenburgh, Christiaan; Manini, Todd M; Marsiske, Michael; Mankowski, Robert T; Mutchie, Heather L; Perri, Michael G; Ranka, Sanjay; Rashidi, Parisa; Sandesara, Bhanuprasad; Scarpace, Philip J; Sibille, Kimberly T; Solberg, Laurence M; Someya, Shinichi; Uphold, Connie; Wohlgemuth, Stephanie; Wu, Samuel Shangwu; Pahor, Marco

    2015-11-01

    The concept of 'successful aging' has long intrigued the scientific community. Despite this long-standing interest, a consensus definition has proven to be a difficult task, due to the inherent challenge involved in defining such a complex, multi-dimensional phenomenon. The lack of a clear set of defining characteristics for the construct of successful aging has made comparison of findings across studies difficult and has limited advances in aging research. A consensus on markers of successful aging is furthest developed is the domain of physical functioning. For example, walking speed appears to be an excellent surrogate marker of overall health and predicts the maintenance of physical independence, a cornerstone of successful aging. The purpose of the present article is to provide an overview and discussion of specific health conditions, behavioral factors, and biological mechanisms that mark declining mobility and physical function and promising interventions to counter these effects. With life expectancy continuing to increase in the United States and developed countries throughout the world, there is an increasing public health focus on the maintenance of physical independence among all older adults. PMID:26462882

  15. Integrating Actionable User-defined Faceted Rules into the Hybrid Science Data System for Advanced Rapid Imaging & Analysis

    NASA Astrophysics Data System (ADS)

    Manipon, G. J. M.; Hua, H.; Owen, S. E.; Sacco, G. F.; Agram, P. S.; Moore, A. W.; Yun, S. H.; Fielding, E. J.; Lundgren, P.; Rosen, P. A.; Webb, F.; Liu, Z.; Smith, A. T.; Wilson, B. D.; Simons, M.; Poland, M. P.; Cervelli, P. F.

    2014-12-01

    The Hybrid Science Data System (HySDS) scalably powers the ingestion, metadata extraction, cataloging, high-volume data processing, and publication of the geodetic data products for the Advanced Rapid Imaging & Analysis for Monitoring Hazard (ARIA-MH) project at JPL. HySDS uses a heterogeneous set of worker nodes from private & public clouds as well as virtual & bare-metal machines to perform every aspect of the traditional science data system. For our science data users, the forefront of HySDS is the facet search interface, FacetView, which allows them to browse, filter, and access the published products. Users are able to explore the collection of product metadata information and apply multiple filters to constrain the result set down to their particular interests. It allows them to download these faceted products for further analysis and generation of derived products. However, we have also employed a novel approach to faceting where it is also used to apply constraints for custom monitoring of products, system resources, and triggers for automated data processing. The power of the facet search interface is well documented across various domains and its usefulness is rooted in the current state of existence of metadata. However, user needs usually extend beyond what is currently present in the data system. A user interested in synthetic aperture radar (SAR) data over Kilauea will download them from FacetView but would also want email notification of future incoming scenes. The user may even want that data pushed to a remote workstation for automated processing. Better still, these future products could trigger HySDS to run the user's analysis on its array of worker nodes, on behalf of the user, and ingest the resulting derived products. We will present our findings in integrating an ancillary, user-defined, system-driven processing system for HySDS that allows users to define faceted rules based on facet constraints and triggers actions when new SAR data

  16. Advances in Global Water Cycle Science Made Possible by Global Precipitation Mission (GPM)

    NASA Technical Reports Server (NTRS)

    Smith, Eric A.; Starr, David OC. (Technical Monitor)

    2001-01-01

    Within this decade the internationally sponsored Global Precipitation Mission (GPM) will take an important step in creating a global precipitation observing system from space. One perspective for understanding the nature of GPM is that it will be a hierarchical system of datastreams from very high caliber combined dual frequency radar/passive microwave (PMW) rain-radiometer retrievals, to high caliber PMW rain-radiometer only retrievals, and on to blends of the former datastreams with other less-high caliber PMW-based and IR-based rain retrievals. Within the context of NASA's role in global water cycle science and its own Global Water & Energy Cycle (GWEC) program, GPM is the centerpiece mission for improving our understanding of the global water cycle from a space-based measurement perspective. One of the salient problems within our current understanding of the global water and energy cycle is determining whether a change in the rate of the water cycle is accompanying changes in global temperature. As there are a number of ways in which to define a rate-change of the global water cycle, it is not entirely clear as to what constitutes such a determination, This paper presents an overview of the Global Precipitation Mission and how its datasets can be used in a set of quantitative tests within the framework of the oceanic and continental water budget equations to determine comprehensively whether substantive rate changes do accompany perturbations in global temperatures and how such rate changes manifest themselves in both water storage and water flux transport processes.

  17. NEW TEACHING AIDS FOR THE AMERICAN CLASSROOM, A SYMPOSIUM HELD AT THE CENTER FOR ADVANCED STUDY IN THE BEHAVIORAL SCIENCES, NOVEMBER 13-14, 1959.

    ERIC Educational Resources Information Center

    SCHRAMM, WILBUR; AND OTHERS

    A SYMPOSIUM ON THE STATE OF RESEARCH IN INSTRUCTIONAL TELEVISION AND TEACHING MACHINES WAS HELD NOVEMBER 13-14, 1959, AT THE CENTER FOR ADVANCED STUDY IN THE BEHAVIORAL SCIENCES, STANFORD, CALIFORNIA. IT INVOLVED A SMALL GROUP OF SCHOLARS, INFORMED AND EXPERIENCED IN RESEARCH ON THE NEW MEDIA, WHO DISCUSSED CURRENT DEVELOPMENTS AND FUTURE RESEARCH…

  18. Coordination of Advanced Solar Observatory (ASO) Science Working Group (SWG) for the study of instrument accommodation and operational requirements on space station

    NASA Technical Reports Server (NTRS)

    Wu, S. T.

    1989-01-01

    The objectives are to coordinate the activities of the Science Working Group (SWG) of the Advanced Solar Observatory (ASO) for the study of instruments accommodation and operation requirements on board space station. In order to facilitate the progress of the objective, two conferences were organized, together with two small group discussions.

  19. Integration Science and Technology of Advanced Ceramics for Energy and Environmental Applications

    NASA Technical Reports Server (NTRS)

    Singh, M.

    2012-01-01

    The discovery of new and innovative materials has been known to culminate in major turning points in human history. The transformative impact and functional manifestation of new materials have been demonstrated in every historical era by their integration into new products, systems, assemblies, and devices. In modern times, the integration of new materials into usable products has a special relevance for the technological development and economic competitiveness of industrial societies. Advanced ceramic technologies dramatically impact the energy and environmental landscape due to potential wide scale applications in all aspects of energy production, storage, distribution, conservation, and efficiency. Examples include gas turbine propulsion systems, fuel cells, thermoelectrics, photovoltaics, distribution and transmission systems based on superconductors, nuclear power generation, and waste disposal. Robust ceramic integration technologies enable hierarchical design and manufacturing of intricate ceramic components starting with geometrically simpler units that are subsequently joined to themselves and/or to metals to create components with progressively higher levels of complexity and functionality. However, for the development of robust and reliable integrated systems with optimum performance under different operating conditions, the detailed understanding of various thermochemical and thermomechanical factors is critical. Different approaches are required for the integration of ceramic-metal and ceramic-ceramic systems across length scales (macro to nano). In this presentation, a few examples of integration of ceramic to metals and ceramic to ceramic systems will be presented. Various challenges and opportunities in design, fabrication, and testing of integrated similar (ceramic-ceramic) and dissimilar (ceramic-metal) material systems will be discussed. Potential opportunities and need for the development of innovative design philosophies, approaches, and

  20. Advanced neutron irradiation system using Texas A&M University Nuclear Science Center Reactor

    NASA Astrophysics Data System (ADS)

    Jang, Si Young

    A heavily filtered fast neutron irradiation system (FNIS) was developed for a variety of applications, including the study of long-term health effects of fast neutrons by evaluating the biological mechanisms of damage in cultured cells and living animals such as rats or mice. This irradiation system includes an exposure cave made with a lead-bismuth alloy, a cave positioning system, a gamma and neutron monitoring system, a sample transfer system, and interchangeable filters. This system was installed in the irradiation cell of the Texas A&M University Nuclear Science Center Reactor (NSCR). By increasing the thickness of the lead-bismuth alloy, the neutron spectra were shifted into lower energies by the scattering interactions of fast neutrons with the alloy. It is possible, therefore, by changing the alloy thickness, to produce distinctly different dose weighted neutron spectra inside the exposure cave of the FNIS. The calculated neutron spectra showed close agreement with the results of activation foil measurements, unfolded by SAND-II close to the cell window. However, there was a considerable less agreement for locations far away from the cell window. Even though the magnitude of values such as neutron flux and tissue kerma rates in air differed, the weighted average neutron energies showed close agreement between the MCNP and SAND-II since the normalized neutron spectra were in a good agreement each other. A paired ion chamber system was constructed, one with a tissue equivalent plastic (A-150) and propane gas for total dose monitoring, and another with graphite and argon for photon dose monitoring. Using the pair of detectors, the neutron to gamma ratio can be inferred. With the 20 cm-thick FNIS, the absorbed dose rates of neutrons measured with the paired ion chamber method and calculated with the SAND-II results were 13.7 +/- 0.02 Gy/min and 15.5 Gy/min, respectively. The absorbed dose rate of photons and the gamma contribution to total dose were 6.7 x 10

  1. Science-Based Approach for Advancing Marine and Hydrokinetic Energy: Integrating Numerical Simulations with Experiments

    NASA Astrophysics Data System (ADS)

    Sotiropoulos, F.; Kang, S.; Chamorro, L. P.; Hill, C.

    2011-12-01

    The field of MHK energy is still in its infancy lagging approximately a decade or more behind the technology and development progress made in wind energy engineering. Marine environments are characterized by complex topography and three-dimensional (3D) turbulent flows, which can greatly affect the performance and structural integrity of MHK devices and impact the Levelized Cost of Energy (LCoE). Since the deployment of multi-turbine arrays is envisioned for field applications, turbine-to-turbine interactions and turbine-bathymetry interactions need to be understood and properly modeled so that MHK arrays can be optimized on a site specific basis. Furthermore, turbulence induced by MHK turbines alters and interacts with the nearby ecosystem and could potentially impact aquatic habitats. Increased turbulence in the wake of MHK devices can also change the shear stress imposed on the bed ultimately affecting the sediment transport and suspension processes in the wake of these structures. Such effects, however, remain today largely unexplored. In this work a science-based approach integrating state-of-the-art experimentation with high-resolution computational fluid dynamics is proposed as a powerful strategy for optimizing the performance of MHK devices and assessing environmental impacts. A novel numerical framework is developed for carrying out Large-Eddy Simulation (LES) in arbitrarily complex domains with embedded MHK devices. The model is able to resolve the geometrical complexity of real-life MHK devices using the Curvilinear Immersed Boundary (CURVIB) method along with a wall model for handling the flow near solid surfaces. Calculations are carried out for an axial flow hydrokinetic turbine mounted on the bed of rectangular open channel on a grid with nearly 200 million grid nodes. The approach flow corresponds to fully developed turbulent open channel flow and is obtained from a separate LES calculation. The specific case corresponds to that studied

  2. Advancing Innovation Through Collaboration: Implementation of the NASA Space Life Sciences Strategy

    NASA Technical Reports Server (NTRS)

    Davis, Jeffrey R.; Richard, Elizabeth E.

    2010-01-01

    On October 18, 2010, the NASA Human Health and Performance center (NHHPC) was opened to enable collaboration among government, academic and industry members. Membership rapidly grew to 90 members (http://nhhpc.nasa.gov ) and members began identifying collaborative projects as detailed in this article. In addition, a first workshop in open collaboration and innovation was conducted on January 19, 2011 by the NHHPC resulting in additional challenges and projects for further development. This first workshop was a result of the SLSD successes in running open innovation challenges over the past two years. In 2008, the NASA Johnson Space Center, Space Life Sciences Directorate (SLSD) began pilot projects in open innovation (crowd sourcing) to determine if these new internet-based platforms could indeed find solutions to difficult technical problems. From 2008 to 2010, the SLSD issued 34 challenges, 14 externally and 20 internally. The 14 external challenges were conducted through three different vendors: InnoCentive, Yet2.com and TopCoder. The 20 internal challenges were conducted using the InnoCentive platform, customized to NASA use, and promoted as NASA@Work. The results from the 34 challenges involved not only technical solutions that were reported previously at the 61st IAC, but also the formation of new collaborative relationships. For example, the TopCoder pilot was expanded by the NASA Space Operations Mission Directorate to the NASA Tournament Lab in collaboration with Harvard Business School and TopCoder. Building on these initial successes, the NHHPC workshop in January of 2011, and ongoing NHHPC member discussions, several important collaborations have been developed: (1) Space Act Agreement between NASA and GE for collaborative projects (2) NASA and academia for a Visual Impairment / Intracranial Hypertension summit (February 2011) (3) NASA and the DoD through the Defense Venture Catalyst Initiative (DeVenCI) for a technical needs workshop (June 2011) (4

  3. Advances in Provenance Tracking and Configuration Management for Earth Science Data

    NASA Astrophysics Data System (ADS)

    Barkstrom, B. R.

    2008-12-01

    Production of Earth science data involves two different production paradigms: 1. Large scale, batch production in which a network of programs and files create a collection of data for access by users 2. Small scale, fine-grained production in which users interact with data in files or databases These two paradigms lead to two different models for configuration management of data. The first model is one that recognizes that data production is similar to other large-scale manufacturing processes and inventories both the collection of files, the processes the produce them, and the connections between the files and the processes. This model requires traversing the mathematical graph created by the network of processes and files. The second model is better described as a workflow that modifies the data by fine- grained transactions. In this case, provenance tracking is equivalent to tracking the history of transactions created by the workflow. In the large scale production paradigm, the rates of data ingest and the number of processes and files is sufficiently large that production needs to be automated. For example, in the upcoming NPOESS Preparatory Project (NPP), a typical time granularity for ingested data files is about 86 seconds. A single spectral channel from the VIIRS instrument on this satellite produces about 1000 files per day of calibrated data. Given the large number of channels on this instrument, production must be highly automated. An archive must be prepared to catalog millions of files per year. In this situation, data producers operate by creating source code that the production system compiles and links into executable objects. The executable code is often unchanged over many instances, so that production is very homogeneous over extended periods of time. This fact means that versioning of data products is also quite discrete and leads naturally to a hierarchical inventory structure. In the small scale production paradigm, the number of files is

  4. Science-based Regulatory Decisions.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The most recent joint State/Federal Citrus Canker Eradication Program (CCEP) ended in 2006 after 10 yrs and a total cost of $1 billion. Although the press and a few outspoken residents claim it was a failure, it was not. The program held off Citrus canker (CC, caused by Xanthomonas citri ssp....

  5. The Advanced Gamma-ray Imaging System (AGIS)--Science Highlights

    SciTech Connect

    Buckley, J.; Krawczynski, H.; Coppi, P.; Digel, S.; Funk, S.; Krennrich, F.; Pohl, M.; Romani, R.; Vassiliev, V.

    2008-12-24

    The Advanced Gamma-ray Imaging System (AGIS), a future gamma-ray telescope consisting of an array of {approx}50 atmospheric Cherenkov telescopes distributed over an area of {approx}1 km{sup 2}, will provide a powerful new tool for exploring the high-energy universe. The order-of-magnitude increase in sensitivity and improved angular resolution could provide the first detailed images of {gamma}-ray emission from other nearby galaxies or galaxy clusters. The large effective area will provide unprecedented sensitivity to short transients (such as flares from AGNs and GRBs) probing both intrinsic spectral variability (revealing the details of the acceleration mechanism and geometry) as well as constraining the high-energy dispersion in the velocity of light (probing the structure of spacetime and Lorentz invariance). A wide field of view ({approx}4 times that of current instruments) and excellent angular resolution (several times better than current instruments) will allow for an unprecedented survey of the Galactic plane, providing a deep unobscured survey of SNRs, X-ray binaries, pulsar-wind nebulae, molecular cloud complexes and other sources. The differential flux sensitivity of {approx}10{sup -13} erg cm{sup -2} sec{sup -1} will rival the most sensitive X-ray instruments for these extended Galactic sources. The excellent capabilities of AGIS at energies below 100 GeV will provide sensitivity to AGN and GRBs out to cosmological redshifts, increasing the number of AGNs detected at high energies from about 20 to more than 100, permitting population studies that will provide valuable insights into both a unified model for AGN and a detailed measurement of the effects of intergalactic absorption from the diffuse extragalactic background light. A new instrument with fast-slewing wide-field telescopes could provide detections of a number of long-duration GRBs providing important physical constraints from this new spectral component. The new array will also have excellent

  6. A phenomenological analysis of the essence of the science education experience as perceived by female high school physics and advanced chemistry students

    NASA Astrophysics Data System (ADS)

    Papadimitriou, Michael

    The purpose of this phenomenological study was to describe the essential elements of the current science education experience as constructed by twelve female high school physics and advanced chemistry students. The expressed desired outcome was a description of the phenomenon from a participant point of view. Student recollections and interpretations of experiences were assessed for a twelve-week period. Data sources were student journals, autobiographies, interviews, focus group interviews and researcher observations. In addition, each participant completed the Test of Science Related Attitudes (Fraser, 1981) in order to create attitude profiles for triangulation with other data. While a wide range of aspects of the science education experience emerged, results showed that female students describe and interpret their science education experiences on the basis of actual interest in science, early science experiences, perception of ability, self-confidence, teacher attributes, parental and peer interaction, societal expectations, the nature of science, and gender. Of these factors, specifically, interest and curiosity, societal influence, the nature of science, lack of in-school experiences, the desire to help others, and general parent support were most impacting upon experience and the desire to continue science study. Moreover, the interaction of these factors is relevant. Very simply, early experiences are crucial to interest development. In general, parents can enhance this interest by providing science-related experiences. In the absence of early in-school experiences (i.e., which the participants reported), these out-of-school experiences become crucial. More importantly, quality instruction and parent and peer support are needed to foster science interest and to overcome the powerfully negative influence of society, the discriminatory nature of science, and the lack of experiences.

  7. Recent advances in bio-logging science: Technologies and methods for understanding animal behaviour and physiology and their environments

    NASA Astrophysics Data System (ADS)

    Evans, K.; Lea, M.-A.; Patterson, T. A.

    2013-04-01

    The deployment of an ever-evolving array of animal-borne telemetry and data logging devices is rapidly increasing our understanding of the movement, behaviour and physiology of a variety species and the complex, and often highly dynamic, environments they use and respond to. The rapid rate at which new technologies, improvements to current technologies and new analytical techniques are being developed has meant that movements, behaviour and physiological processes are being quantified at finer spatial and temporal scales than ever before. The Fourth International Symposium on Bio-logging Science, held on 14-18 March in Hobart, Australia, brought together scientists across multiple disciplines to discuss the latest innovations in technology, applications and analytical techniques in bio-logging science, building on research presented at three previous conferences. Here we present an update on the state of bio-logging research and provide some views on the future of this field of research. Papers were grouped into five theme areas: (i) Southern Ocean ecosystems; (ii) fishery and biodiversity management applications; (iii) from individuals to populations—inferences of population dynamics from individuals; (iv) conservation biology and (v) habitat modelling. Papers reflected wider uptake of newer technologies, with a greater proportion of studies utilising accelerometry and incorporating advances in statistical modelling of behaviour and habitats, especially via state space modelling methods. Environmental data collected by tags at increasing accuracies are now having wider application beyond the bio-logging community, providing important oceanographic data from regions difficult to sample using traditional methodologies. Partnerships between multiple organisations are also now enabling regional assessments of species movements, behaviour and physiology at population scales and will continue to be important for applying bio-logging technologies to species

  8. Type 2 diabetes, genomics, and nursing: necessary next steps to advance the science into improved, personalized care.

    PubMed

    Underwood, Patricia C

    2011-01-01

    Type 2 diabetes mellitus (T2DM) is an inherited, chronic disorder with long-term complications; including cardiovascular disease the leading cause of mortality in the United States. The prevalence of T2DM and its complications are on the rise in the United States, highlighting the need for improved individualized prevention and treatment strategies. Exciting advancements in the field of genomics has led to the recent discovery of numerous genetic markers for T2DM; completing a promising first step toward improved, individualized prevention and treatment strategies for T2DM. These genomic markers, identified using genome-wide association studies (GWAS), candidate gene, and rare variant methodology, identify new physiologic pathways underlying the development of T2DM. Much more work is needed to successfully translate the identification of genetic markers for T2DM into improved, individualized prevention and treatment strategies. As front line providers and leaders of prevention and treatment strategies for chronic disease, nurses, nurse practitioners, and nurse scientists must contribute to this translational effort. Thus, it is important for nurses at all levels to (a) be aware of the current science of genetics and T2DM and (b) participate in the translation of this genetic information into improved, personalized patient care. The aim of this review is to (a) provide an overview of the current state of the science of genetic markers and T2DM and (b) highlight essential next steps to successfully translate the identification of genetic markers for T2DM into improved prevention and treatment strategies; focusing particularly on the role of nursing in this process. PMID:22891509

  9. Resource Endowments and Responses to Regulatory Pressure: Publications of Economics, Management, and Political Science Departments of Turkish Universities in Indexed Journals, 2000-2008

    ERIC Educational Resources Information Center

    Onder, Cetin; Kasapoglu-Onder, Rana

    2011-01-01

    This paper investigates how differences in resource endowments of universities shape variation in their response to regulatory pressures. Earlier research on higher education institutions tends to conceive regulatory rules as the primary basis of action and does not attend to differences in the salient characteristics of universities. This paper…

  10. Advanced High School Biology in an Era of Rapid Change: A Summary of the Biology Panel Report from the NRC Committee on Programs for Advanced Study of Mathematics and Science in American High Schools

    PubMed Central

    2002-01-01

    A recently released National Research Council (NRC) report, Learning and Understanding: Improving Advanced Study of Mathematics and Science in U.S. High Schools, evaluated and recommended changes in the Advanced Placement (AP), International Baccalaureate (IB), and other advanced secondary school science programs. As part of this study, discipline-specific panels were formed to evaluate advanced programs in biology, chemistry, physics, and mathematics. Among the conclusions of the Content Panel for Biology were that AP courses in particular suffer from inadequate quality control as well as excessive pressure to fulfill their advanced placement function, which encourages teachers to attempt coverage of all areas of biology and emphasize memorization of facts rather than in-depth understanding. In this essay, the Panel's principal findings are discussed, with an emphasis on its recommendation that colleges and universities should be strongly discouraged from using performance on either the AP examination or the IB examination as the sole basis for automatic placement out of required introductory courses for biology majors and distribution requirements for nonmajors. PMID:12669097

  11. Education for the Talented in Mathematics and Science. A Report of a Joint Conference of the Cooperative Committee on the Teaching of Science and Mathematics of the American Association for the Advancement of Science and the United States Office of Education. Bulletin, 1952, No. 15

    ERIC Educational Resources Information Center

    Brown, Kenneth E.; Johnson, Philip G.

    1953-01-01

    The Cooperative Committee on the Teaching of Science and Mathematics of the American Association for the Advancement of Science that participated in planning for and publishing this bulletin is composed of representatives of seventeen national scientific and mathematical societies including representatives from the associated teaching…

  12. Public understanding of participation in regulatory decision-making: The case of bottled water quality standards in India.

    PubMed

    Bhaduri, Saradindu; Sharma, Aviram

    2014-05-01

    "Science-based" standards are an integral part of modern regulatory systems. Studies on "public understanding of science" mostly focus on high technology areas in advanced economies. In contrast, the present study analyses the public understanding of regulation in the context of standard-setting for bottled water quality in India. Using primary data, the econometric models of this paper show that public understanding of participation in regulation depends on awareness of, and trust in, existing regulatory practices in a complex, non-linear manner. In this light, the paper argues that "deficit model" and "dialogue model" frameworks cannot be seen as two mutually exclusive frameworks of analyses. PMID:23825253

  13. Preparedness of the CTSA's structural and scientific assets to support the mission of the National Center for Advancing Translational Sciences (NCATS)

    PubMed Central

    Bernard, Gordon R.

    2012-01-01

    The formation of the National Center for Advancing Translational Sciences (NCATS) brings new promise for moving basic and discoveries to clinical practice, ultimately improving the health of the nation. The CTSA sites, now housed with NCATS, are organized and prepared to support in this endeavor. The CTSAs provide a foundation for capitalizing on such promise through provision of a disease-agnostic infrastructure devoted to C&T science, maintenance of training programs designed for C&T investigators of the future, by incentivizing institutional reorganization and by cultivating institutional support. PMID:22507116

  14. Development of instrumentation for surface, interface and thin film science at the Advanced Photon Source. Final Technical Report for period September 15, 1994 - September 14, 2000

    SciTech Connect

    Bedzyk, Michael J.

    2000-09-01

    The P.I. and his research term successfully used the funds from the DOE Instrumentation grant entitled ''Development of Instrumentation for Surface, Interface and Thin Film Science at the Advanced Photon Source'' to design, build, test, and commission a customized surface science x-ray scattering/spectroscopy chamber. This instrumentation, which is presently in use at an APS x-ray undulator beam line operated by the DuPont-Northwestern-Dow Collaborative Access Team, is used for x-ray measurements of surface, interface, thin film, and nano-structures.

  15. In Defense of Basic Science Funding: Today’s Scientific Discovery Is Tomorrow’s Medical Advance

    PubMed Central

    Tessier-Lavigne, Marc

    2013-01-01

    In this address, I will discuss the importance of basic science in tackling our health problems. I will also describe how the funding cuts are damaging our economic competitiveness and turning our young people away from science. PMID:23686129

  16. Advances in Biological Science.

    ERIC Educational Resources Information Center

    Oppenheimer, Steven B.; And Others

    1988-01-01

    Reviews major developments in areas that are at the cutting edge of biological research. Areas include: human anti-cancer gene, recombinant DNA techniques for the detection of Huntington disease carriers, and marine biology. (CW)

  17. "The first step is admitting you have a problem…": the process of advancing science communication in Landscape Conservation Cooperatives in Alaska

    NASA Astrophysics Data System (ADS)

    Buxbaum, T. M.; Trainor, S.; Warner, N.; Timm, K.

    2015-12-01

    Climate change is impacting ecological systems, coastal processes, and environmental disturbance regimes in Alaska, leading to a pressing need to communicate reliable scientific information about climate change, its impacts, and future projections for land and resource management and decision-making. However, little research has been done to dissect and analyze the process of making the results of scientific inquiry directly relevant and usable in resource management. Based within the Science Application division of the US Fish and Wildlife Service, Landscape Conservation Cooperatives (LCCs) are regional conservation science partnerships that provide scientific and technical expertise needed to support conservation planning at landscape scales and promote collaboration in defining shared conservation goals. The five LCCs with jurisdiction in Alaska recently held a training workshop with the goals of advancing staff understanding and skills related to science communication and translation. We report here preliminary results from analysis of workshop discussions and pre- and post- workshop interviews and surveys revealing expectations, assumptions, and mental models regarding science communication and the process of conducting use-inspired science. Generalizable conclusions can assist scientists and boundary organizations bridge knowledge gaps between science and resource management.

  18. The core to regulatory reform

    SciTech Connect

    Partridge, J.W. Jr.

    1993-06-15

    Federal Energy Regulatory Commission (FERC) Orders 436, 500, and 636, the Clean Air Act Amendments of 1990, Public Utility Holding Company Act reform, and the 1992 Energy Policy Act all can have significant effects on an LDC's operations. Such changes in an LDC's environments must be balanced by changes within the utility, its marketplace, and its state regulatory environment. The question is where to start. For Columbia Gas Distribution Cos., based in Columbus, OH, the new operating foundation begins with each employee. Internal strength is critical in designing initiatives that meet the needs of the marketplace and are well-received by regulators. Employees must understand not only the regulatory environment in which the LDC operates, but also how their work contributes to a positive regulatory relationship. To achieve this, Columbia initiated the COntinuing Regulatory Education program, or CORE, in 1991. CORE is a regulatory-focused, information-initiative program coordinated by Columbia's Regulatory Policy, Planning, and Government Affairs Department. The CORE programs can take many forms, such as emerging issue discussions, dialogues with regulators and key parties, updates on regulatory fillings, regulatory policy meetings, and formal training classes. The speakers and discussion facilitators can range from human resource department trainers to senior officers, from regulatory department staff members to external experts, or from state commissioners to executives from other LDCs. The goals of CORE initiatives are to: Support a professional level of regulatory expertise through employee participation in well-developed regulatory programs presented by credible experts. Encourage a constructive state regulatory environment founded on communication and cooperation. CORE achieves these goals via five program levels: introductory basics, advanced learning, professional expertise, crossfunctional dialogues, and external idea exchanges.

  19. Recruiting the Future Workforce in the Geosciences And the Role of the Society for the Advancement of Chicanos and Native Americans in Science (SACNAS)

    NASA Astrophysics Data System (ADS)

    Velasco, A. A.

    2004-12-01

    The declining interest in the physical sciences among U.S. students has been recognized as a vital issue for the continued health of science. In particular, the declining number of geoscience students, especially US citizens, threatens the country's future preparedness in natural hazards mitigation, resource development, national security, and education. Furthermore, the geosciences suffer from poor representation among underrepresented groups, even by comparison to other sciences and engineering. Thus, exciting young scientists from all backgrounds into the geosciences must remain a high priority for all geoscientists, educational institutes, national laboratories, and industry. Exciting young scientists into the geosciences must remain a high priority for all geoscientists, educational institutes, national laboratories, and industry. I identify some key factors that may be contributing to the decline in the science workforce as well as the geoscience workforce, including generational and cultural attitudes, and the changing demographics in the U.S. I propose that the workforce and diversity issues are intertwined and both must be addressed for the survival of geoscience. To address diversity specifically, several organizations have been successful in mentoring and recruiting minorities into science. The Society for the Advancement of Chicanos and Native Americans in Science (SACNAS) focuses on encouraging undergraduate and graduate Hispanic and American Indian students to pursue higher degrees. For over 30 years, SACNAS has provided strong national leadership in improving science and math education, as well as expanding opportunities for minorities in the scientific workforce and academia. Currently, SACNAS has added a geological science emphasis to its existing programs to address the need to diversify the field. This presentation will also outline this approach, and outline how SACNAS has been able to grow over the past 30 years.

  20. Support for chemistry symposia at the 2011 American Association for the Advancement of Science meeting, February 17-21 2011

    SciTech Connect

    Charles Casey

    2011-08-20

    This proposal supported Chemistry Symposia at the 2011 American Association for the Advancement of Science (AAAS) Meeting in Washington, DC February 17-21, 2011. The Chemistry Section of AAAS presented an unusually strong set of symposia for the 2011 AAAS meeting to help celebrate the 2011 International Year of Chemistry. The AAAS meeting provided an unusual opportunity to convey the excitement and importance of chemistry to a very broad audience and allowed access to a large contingent of the scientific press. Excellent suggestions for symposia were received from AAAS Chemistry Fellows and from the chairs of the American Chemical Society Technical Divisions. The AAAS Chemistry executive committee selected topics that would have wide appeal to scientists, the public, and the press for formal proposals of symposia. The symposia proposals were peer reviewed by AAAS. The Chemistry Section made a strong case to the program selection committee for approval of the chemistry symposia and 6 were approved for the 2011 annual meeting. The titles of the approved symposia were: (1) Powering the Planet: Generation of Clean Fuels from Sunlight and Water, (2) Biological Role and Consequences of Intrinsic Protein Disorder, (3) Chemically Speaking: How Organisms Talk to Each Other, (4) Molecular Self-Assembly and Artificial Molecular Machines, (5) Frontiers in Organic Materials for Information Processing, Energy and Sensors, and (6) Celebrating Marie Curie's 100th Anniversary of Her Nobel Prize in Chemistry. The Chemistry Section of AAAS is provided with funds to support only 1-2 symposia a year. Because of the much greater number of symposia approved in conjunction with observance of the 2011 International Year of Chemistry, additional support was sought from DOE to help support the 30 invited speakers and 8 symposia moderators/organizers. Support for the symposia provided the opportunity to highlight the excitement of current chemical research, to educate the public about the

  1. SUPPORT FOR CHEMISTRY SYMPOSIA AT THE 2011 AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE MEETING FEBRUARY 17-21, 2011

    SciTech Connect

    Prof. Charles Casey, University of Wisconsin-Madison

    2011-08-20

    This proposal supported Chemistry Symposia at the 2011 American Association for the Advancement of Science (AAAS) Meeting in Washington, DC February 17-21, 2011. The Chemistry Section of AAAS presented an unusually strong set of symposia for the 2011 AAAS meeting to help celebrate the 2011 International Year of Chemistry. The AAAS meeting provided an unusual opportunity to convey the excitement and importance of chemistry to a very broad audience and allowed access to a large contingent of the scientific press. Excellent suggestions for symposia were received from AAAS Chemistry Fellows and from the chairs of the American Chemical Society Technical Divisions. The AAAS Chemistry executive committee selected topics that would have wide appeal to scientists, the public, and the press for formal proposals of symposia. The symposia proposals were peer reviewed by AAAS. The Chemistry Section made a strong case to the program selection committee for approval of the chemistry symposia and 6 were approved for the 2011 annual meeting. The titles of the approved symposia were: (1) Powering the Planet: Generation of Clean Fuels from Sunlight and Water, (2) Biological Role and Consequences of Intrinsic Protein Disorder, (3) Chemically Speaking: How Organisms Talk to Each Other, (4) Molecular Self-Assembly and Artificial Molecular Machines, (5) Frontiers in Organic Materials for Information Processing, Energy and Sensors, and (6) Celebrating Marie Curie's 100th Anniversary of Her Nobel Prize in Chemistry. The Chemistry Section of AAAS is provided with funds to support only 1-2 symposia a year. Because of the much greater number of symposia approved in conjunction with observance of the 2011 International Year of Chemistry, additional support was sought from DOE to help support the 30 invited speakers and 8 symposia moderators/organizers. Support for the symposia provided the opportunity to highlight the excitement of current chemical research, to educate the public about the

  2. Geo-Semantic Framework for Integrating Long-Tail Data and Model Resources for Advancing Earth System Science

    NASA Astrophysics Data System (ADS)

    Elag, M.; Kumar, P.

    2014-12-01

    Often, scientists and small research groups collect data, which target to address issues and have limited geographic or temporal range. A large number of such collections together constitute a large database that is of immense value to Earth Science studies. Complexity of integrating these data include heterogeneity in dimensions, coordinate systems, scales, variables, providers, users and contexts. They have been defined as long-tail data. Similarly, we use "long-tail models" to characterize a heterogeneous collection of models and/or modules developed for targeted problems by individuals and small groups, which together provide a large valuable collection. Complexity of integrating across these models include differing variable names and units for the same concept, model runs at different time steps and spatial resolution, use of differing naming and reference conventions, etc. Ability to "integrate long-tail models and data" will provide an opportunity for the interoperability and reusability of communities' resources, where not only models can be combined in a workflow, but each model will be able to discover and (re)use data in application specific context of space, time and questions. This capability is essential to represent, understand, predict, and manage heterogeneous and interconnected processes and activities by harnessing the complex, heterogeneous, and extensive set of distributed resources. Because of the staggering production rate of long-tail models and data resulting from the advances in computational, sensing, and information technologies, an important challenge arises: how can geoinformatics bring together these resources seamlessly, given the inherent complexity among model and data resources that span across various domains. We will present a semantic-based framework to support integration of "long-tail" models and data. This builds on existing technologies including: (i) SEAD (Sustainable Environmental Actionable Data) which supports curation

  3. A Framework for Linking High-Throughput Modeling and Measurement Efforts to Advance 21st Century Exposure Science

    EPA Science Inventory

    The past five years have witnessed a rapid shift in the exposure science and toxicology communities towards high-throughput (HT) analyses of chemicals as potential stressors of human and ecological health. Modeling efforts have largely led the charge in the exposure science field...

  4. Prospects for Policy Advances in Science and Technology in the Gulf Arab States: "The Role for International Partnerships"

    ERIC Educational Resources Information Center

    Hajjar, David P.; Moran, George W.; Siddiqi, Afreen; Richardson, Joshua E.; Anadon, Laura D.; Narayanamurti, Venkatesh

    2014-01-01

    Science, technology, engineering and mathematics (STEM) policies in the Gulf Arab States are as diverse as the individual economies and political processes that characterize its member states. During the past decade, a number of expert review groups have argued that science and technology policy needs to be reformed and revitalized in the Gulf…

  5. Genetic algorithms and genetic programming for multiscale modeling: Applications in materials science and chemistry and advances in scalability

    NASA Astrophysics Data System (ADS)

    Sastry, Kumara Narasimha

    2007-03-01

    Effective and efficient rnultiscale modeling is essential to advance both the science and synthesis in a, wide array of fields such as physics, chemistry, materials science; biology, biotechnology and pharmacology. This study investigates the efficacy and potential of rising genetic algorithms for rnultiscale materials modeling and addresses some of the challenges involved in designing competent algorithms that solve hard problems quickly, reliably and accurately. In particular, this thesis demonstrates the use of genetic algorithms (GAs) and genetic programming (GP) in multiscale modeling with the help of two non-trivial case studies in materials science and chemistry. The first case study explores the utility of genetic programming (GP) in multi-timescaling alloy kinetics simulations. In essence, GP is used to bridge molecular dynamics and kinetic Monte Carlo methods to span orders-of-magnitude in simulation time. Specifically, GP is used to regress symbolically an inline barrier function from a limited set of molecular dynamics simulations to enable kinetic Monte Carlo that simulate seconds of real time. Results on a non-trivial example of vacancy-assisted migration on a surface of a face-centered cubic (fcc) Copper-Cobalt (CuxCo 1-x) alloy show that GP predicts all barriers with 0.1% error from calculations for less than 3% of active configurations, independent of type of potentials used to obtain the learning set of barriers via molecular dynamics. The resulting method enables 2--9 orders-of-magnitude increase in real-time dynamics simulations taking 4--7 orders-of-magnitude less CPU time. The second case study presents the application of multiobjective genetic algorithms (MOGAs) in multiscaling quantum chemistry simulations. Specifically, MOGAs are used to bridge high-level quantum chemistry and semiempirical methods to provide accurate representation of complex molecular excited-state and ground-state behavior. Results on ethylene and benzene---two common

  6. Recent advances in engineering science; Proceedings of the A. Cemal Eringen Symposium, University of California, Berkeley, June 20-22, 1988

    NASA Technical Reports Server (NTRS)

    Koh, Severino L. (Editor); Speziale, Charles G. (Editor)

    1989-01-01

    Various papers on recent advances in engineering science are presented. Some individual topics addressed include: advances in adaptive methods in computational fluid mechanics, mixtures of two medicomorphic materials, computer tests of rubber elasticity, shear bands in isotropic micropolar elastic materials, nonlinear surface wave and resonator effects in magnetostrictive crystals, simulation of electrically enhanced fibrous filtration, plasticity theory of granular materials, dynamics of viscoelastic media with internal oscillators, postcritical behavior of a cantilever bar, boundary value problems in nonlocal elasticity, stability of flexible structures with random parameters, electromagnetic tornadoes in earth's ionosphere and magnetosphere, helicity fluctuations and the energy cascade in turbulence, mechanics of interfacial zones in bonded materials, propagation of a normal shock in a varying area duct, analytical mechanics of fracture and fatigue.

  7. Equipment concept design and development plans for microgravity science and applications research on space station: Combustion tunnel, laser diagnostic system, advanced modular furnace, integrated electronics laboratory

    NASA Technical Reports Server (NTRS)

    Uhran, M. L.; Youngblood, W. W.; Georgekutty, T.; Fiske, M. R.; Wear, W. O.

    1986-01-01

    Taking advantage of the microgravity environment of space NASA has initiated the preliminary design of a permanently manned space station that will support technological advances in process science and stimulate the development of new and improved materials having applications across the commercial spectrum. Previous studies have been performed to define from the researcher's perspective, the requirements for laboratory equipment to accommodate microgravity experiments on the space station. Functional requirements for the identified experimental apparatus and support equipment were determined. From these hardware requirements, several items were selected for concept designs and subsequent formulation of development plans. This report documents the concept designs and development plans for two items of experiment apparatus - the Combustion Tunnel and the Advanced Modular Furnace, and two items of support equipment the Laser Diagnostic System and the Integrated Electronics Laboratory. For each concept design, key technology developments were identified that are required to enable or enhance the development of the respective hardware.

  8. The NSF-Supported ADVANCE Initiative at the University of Michigan Aimed at Successful Recruitment and Retention of Women Faculty in Science and Engineering

    NASA Astrophysics Data System (ADS)

    Mukasa, S. B.; Committee, S.

    2004-12-01

    The University of Michigan obtained funding from the NSF ADVANCE Program for 2001-2006 to devise and implement strategies to improve representation and climate for its tenure-track women faculty in the natural sciences departments and the College of Engineering. In addition to increased representation and an improved campus environment for women faculty in science and engineering, the initiative aims to positively affect - through exposure to role models - the expectations and attitudes of the many women and men who are graduate and undergraduate students in these fields who make a sizeable pool from which future faculty are going to be drawn. This initiative was launched with a campus-wide survey to pinpoint problem areas, followed by the appointment of a committee of senior faculty now known as "Science and Technology Recruiting to Improve Diversity and Excellence" or STRIDE to provide information and advice about practices that will maximize the likelihood that well-qualified female and minority candidates for faculty positions will be identified, and, if selected for offers, recruited, retained, and promoted at the University of Michigan. The principal activities of STRIDE have so far included (i) helping in the development of an easy-to-navigate website with information about the ADVANCE project (URL: http://www.umich.edu/~advproj/index.html); (ii) development of a data-based PowerPoint presentation about non-conscious bias and the low numbers of women faculty in science and engineering; (iii) producing a handbook that offers guidelines for improving recruitment of women and minorities; and (iv) giving presentations in a variety of formats and providing advice to department chairs and other recruitment leaders on search committee composition and search practices. More recently, STRIDE has expanded its scope to include facilitation of departmental climate studies and informal discussions with women faculty about the importance of networking and receiving career

  9. Gerald L. Epstein, PhD: director, center for science, technology, and security policy, American Association for the Advancement of Science (AAAS). Interview by Madeline Drexler.

    PubMed

    Epstein, Gerald L

    2009-12-01

    Over his entire career, Gerald Epstein has toiled at the nexus of science, technology, and security. From 2003 to 2009, he was Senior Fellow for Science and Security at the Center for Strategic and International Studies Homeland Security Program, where he worked on reducing biological weapons threats, improving national preparedness, and easing potential tensions between the scientific research and national security communities. Epstein came to CSIS from the Institute for Defense Analyses. From 1996 to 2001, he served in the White House Office of Science and Technology Policy. And from 1983 to 1989, and again from 1991 until its demise in 1995, Epstein worked at the Congressional Office of Technology Assessment, where he directed a study on the proliferation of weapons of mass destruction, alongside research on other global security topics. A recognized expert in biological risk reduction, Epstein was actually trained as a physicist, having received SB degrees in physics and electrical engineering from MIT, and a PhD in physics from the University of California at Berkeley. How, then, did he come to study the evolving threat from bioterrorism? "What compelled me about bioterrorism was that it was a stellar example of a topic that would lead to a train wreck between the scientific community and the security community unless they figured out how to work together," he said. "The distance between a laboratory and a very large consequence event is a lot shorter in biology than in any other field. I got into bioterrorism to help make sure that the security community doesn't get so scared of the science that it shuts it down, and that the science community isn't so oblivious of security concerns that it pays no attention to them." Epstein spoke on November 6, 2009, with contributing writer Madeline Drexler, author of Emerging Epidemics: The Menace of New Infections (Penguin, 2009), an updated version of an earlier volume. Drexler holds a visiting appointment at the

  10. Advancing the Potential of Citizen Science for Urban Water Quality Monitoring: Exploring Research Design and Methodology in New York City

    NASA Astrophysics Data System (ADS)

    Hsueh, D.; Farnham, D. J.; Gibson, R.; McGillis, W. R.; Culligan, P. J.; Cooper, C.; Larson, L.; Mailloux, B. J.; Buchanan, R.; Borus, N.; Zain, N.; Eddowes, D.; Butkiewicz, L.; Loiselle, S. A.

    2015-12-01

    Citizen Science is a fast-growing ecological research tool with proven potential to rapidly produce large datasets. While the fields of astronomy and ornithology demonstrate particularly successful histories of enlisting the public in conducting scientific work, citizen science applications to the field of hydrology have been relatively underutilized. We demonstrate the potential of citizen science for monitoring water quality, particularly in the impervious, urban environment of New York City (NYC) where pollution via stormwater runoff is a leading source of waterway contamination. Through partnerships with HSBC, Earthwatch, and the NYC Water Trail Association, we have trained two citizen science communities to monitor the quality of NYC waterways, testing for a suite of water quality parameters including pH, turbidity, phosphate, nitrate, and Enterococci (an indicator bacteria for the presence of harmful pathogens associated with fecal pollution). We continue to enhance these citizen science programs with two additions to our methodology. First, we designed and produced at-home incubation ovens for Enterococci analysis, and second, we are developing automated photo-imaging for nitrate and phosphate concentrations. These improvements make our work more publicly accessible while maintaining scientific accuracy. We also initiated a volunteer survey assessing the motivations for participation among our citizen scientists. These three endeavors will inform future applications of citizen science for urban hydrological research. Ultimately, the spatiotemporally-rich dataset of waterway quality produced from our citizen science efforts will help advise NYC policy makers about the impacts of green infrastructure and other types of government-led efforts to clean up NYC waterways.

  11. NASA University Research Centers Technical Advances in Aeronautics, Space Sciences and Technology, Earth Systems Sciences, Global Hydrology, and Education. Volumes 2 and 3

    NASA Technical Reports Server (NTRS)

    Coleman, Tommy L. (Editor); White, Bettie (Editor); Goodman, Steven (Editor); Sakimoto, P. (Editor); Randolph, Lynwood (Editor); Rickman, Doug (Editor)

    1998-01-01

    This volume chronicles the proceedings of the 1998 NASA University Research Centers Technical Conference (URC-TC '98), held on February 22-25, 1998, in Huntsville, Alabama. The University Research Centers (URCS) are multidisciplinary research units established by NASA at 11 Historically Black Colleges or Universities (HBCU's) and 3 Other Minority Universities (OMU's) to conduct research work in areas of interest to NASA. The URC Technical Conferences bring together the faculty members and students from the URC's with representatives from other universities, NASA, and the aerospace industry to discuss recent advances in their fields.

  12. Noncoding Regulatory RNAs in Hematopoiesis.

    PubMed

    Jeong, M; Goodell, M A

    2016-01-01

    Hematopoiesis is a dynamic process in which blood cells are continuously generated from hematopoietic stem cells (HSCs). The regulatory mechanisms controlling HSC fate have been studied extensively over the past several decades. Although many protein-coding genes have been shown to regulate hematopoietic differentiation, additional levels of HSC regulation are not well studied. Advances in deep sequencing have revealed many new classes of regulatory noncoding RNAs (ncRNAs), such as enhancer RNAs and antisense ncRNAs. Functional analysis of some of these ncRNAs has provided insights into the molecular mechanisms that regulate hematopoietic development and disease. In this review, we summarize recent advances in our understanding of functional regulatory ncRNAs associated with hematopoietic self-renewal and differentiation, as well as those dysregulated ncRNAs involved in hematologic malignancies. PMID:27137659

  13. Plant science in forest canopies--the first 30 years of advances and challenges (1980-2010).

    PubMed

    Lowman, Margaret D; Schowalter, Timothy D

    2012-04-01

    As an emerging subdiscipline of forest biology, canopy science has undergone a transition from observational, 'oh-wow' exploration to a more hypothesis-driven, experimental arena for rigorous field biology. Although efforts to explore forest canopies have occurred for a century, the new tools to access the treetops during the past 30 yr facilitated not only widespread exploration but also new discoveries about the complexity and global effects of this so-called 'eighth continent of the planet'. The forest canopy is the engine that fixes solar energy in carbohydrates to power interactions among forest components that, in turn, affect regional and global climate, biogeochemical cycling and ecosystem services. Climate change, biodiversity conservation, fresh water conservation, ecosystem productivity, and carbon sequestration represent important components of forest research that benefit from access to the canopy for rigorous study. Although some canopy variables can be observed or measured from the ground, vertical and horizontal variation in environmental conditions and processes within the canopy that determine canopy-atmosphere and canopy-forest floor interactions are best measured within the canopy. Canopy science has matured into a cutting-edge subset of forest research, and the treetops also serve as social and economic drivers for sustainable communities, fostering science education and ecotourism. This interdisciplinary context of forest canopy science has inspired innovative new approaches to environmental stewardship, involving diverse stakeholders. PMID:22348430

  14. Encouraging the pursuit of advanced degrees in science and engineering: Top-down and bottom-up methodologies

    NASA Technical Reports Server (NTRS)

    Maddox, Anthony B.; Smith-Maddox, Renee P.; Penick, Benson E.

    1989-01-01

    The MassPEP/NASA Graduate Research Development Program (GRDP) whose objective is to encourage Black Americans, Mexican Americans, American Indians, Puerto Ricans, and Pacific Islanders to pursue graduate degrees in science and engineering is described. The GRDP employs a top-down or goal driven methodology through five modules which focus on research, graduate school climate, technical writing, standardized examinations, and electronic networking. These modules are designed to develop and reinforce some of the skills necessary to seriously consider the goal of completing a graduate education. The GRDP is a community-based program which seeks to recruit twenty participants from a pool of Boston-area undergraduates enrolled in engineering and science curriculums and recent graduates with engineering and science degrees. The program emphasizes that with sufficient information, its participants can overcome most of the barriers perceived as preventing them from obtaining graduate science and engineering degrees. Experience has shown that the top-down modules may be complemented by a more bottom-up or event-driven methodology. This approach considers events in the academic and professional experiences of participants in order to develop the personal and leadership skills necessary for graduate school and similar endeavors.

  15. School Psychology Publishing Contributions to the Advancement of Knowledge, Science, and Its Application: An Introduction to the Themed Issue

    ERIC Educational Resources Information Center

    Eckert, Tanya L.; Hintze, John M.

    2011-01-01

    This introductory article briefly reviews the studies and commentaries making up this themed issue on the process and products of professional publications in school psychology. Each article highlights important considerations for advancing scholarly scientific publishing in the field of school psychology. A case is made that enhancing the quality…

  16. Government Regulatory

    NASA Astrophysics Data System (ADS)

    Becker, Katie

    Government regulation of food products, food processing, and food preparation is imperative in bringing an unadulterated, nonmisleading, and safe food product to market and is relevant to all areas of food science, including engineering, processing, chemistry, and microbiology. The liability associated with providing consumers with an adulterated or substandard product cannot only tarnish a company's name and reputation, but also impose substantial financial repercussions on the company and those individuals who play an active role in the violation. In order for a company to fully comply with the relevant food laws (both federal and state), an intimate knowledge of food science is required. Individuals knowledgeable in food science play an integral role not only in implementing and counseling food companies/processors to ensure compliance with government regulations, but these individuals are also necessary to the state and federal governments that make and enforce the relevant laws and regulators.

  17. Life sciences

    SciTech Connect

    Day, L.

    1991-04-01

    This document is the 1989--1990 Annual Report for the Life Sciences Divisions of the University of California/Lawrence Berkeley Laboratory. Specific progress reports are included for the Cell and Molecular Biology Division, the Research Medicine and Radiation Biophysics Division (including the Advanced Light Source Life Sciences Center), and the Chemical Biodynamics Division. 450 refs., 46 figs. (MHB)

  18. Students as Mentors and Owners of Geoscience and Environmental Education: Advancing the Science of Climate Change in the Public Schools

    NASA Astrophysics Data System (ADS)

    Schuster, D. A.; Thomas, C. W.; Smith, J. S.; Wood, E. J.; Filippelli, G. M.

    2007-12-01

    The importance of K-12 educational programs and resources that seek to share the science of climate change has recently come into focus. During the fall 2006 AGU meeting, we presented the conceptual framework used to guide both the curriculum and year-one programs of Students as Mentors and Owners of Geoscience and Environmental Education: The Global Warming Road Show. Currently this dynamic, three-phase, tiered mentoring program selects and empowers a diverse population of 11th and 12th grade students from a large urban high school in the Midwest to teach a curriculum on climate change to 7th graders from a local feeder school. In December 2007 we will complete year-one of the program and will present an overview of 1) students' conceptual representations of climate change, 2) the most recent curriculum and programs, and 3) the ongoing program evaluation. We will synthesize these three areas and reflect on how to improve upon year-two of both the curriculum and the program. During various stages of the program, students have constructed concept maps, written in journals, created lesson plans, and participated in focus group interviews. These materials are being analyzed to provide a brief overview of high school students' initial conceptualizations of climate change. During the intensive 2007 summer workshop, these 11th and 12th grade students were supported by university scientists and science educators, secondary science teachers, and museum educators as they attempted to better understand climate change and as they reflected on how to effectively teach this topic to 7th graders. During the fall semester of 2007, the workshop graduates are scheduled to teach 25 to 30 7th graders a five week climate unit. The program will culminate with the 11th and 12th grade student-mentors working with the 7th graders to create a "Road Show," which will be presented to other 7th and 8th graders within the same school district. To ensure that this program is current, a team of

  19. Science and the Mars Science Laboratory

    NASA Video Gallery

    NASA’s newest Mars rover is, the Mars Science Laboratory or Curiosity. It is ready to roam the Red Planet with the biggest and most advanced set of science instruments ever! Follow the curious ro...

  20. Research Advances

    ERIC Educational Resources Information Center

    King, Angela G.

    2004-01-01

    Research advances, a new feature in Journal of Chemical Engineering that brings information about innovations in current areas of research to high school and college science faculty with an intent to provide educators with timely descriptions of latest progress in research that can be integrated into existing courses to update course content and…