Sample records for advisories targeting sensitive

  1. Comparative Analysis of State Fish Consumption Advisories Targeting Sensitive Populations

    PubMed Central

    Scherer, Alison C.; Tsuchiya, Ami; Younglove, Lisa R.; Burbacher, Thomas M.; Faustman, Elaine M.

    2008-01-01

    Objective Fish consumption advisories are issued to warn the public of possible toxicological threats from consuming certain fish species. Although developing fetuses and children are particularly susceptible to toxicants in fish, fish also contain valuable nutrients. Hence, formulating advice for sensitive populations poses challenges. We conducted a comparative analysis of advisory Web sites issued by states to assess health messages that sensitive populations might access. Data sources We evaluated state advisories accessed via the National Listing of Fish Advisories issued by the U.S. Environmental Protection Agency. Data extraction We created criteria to evaluate advisory attributes such as risk and benefit message clarity. Data synthesis All 48 state advisories issued at the time of this analysis targeted children, 90% (43) targeted pregnant women, and 58% (28) targeted women of childbearing age. Only six advisories addressed single contaminants, while the remainder based advice on 2–12 contaminants. Results revealed that advisories associated a dozen contaminants with specific adverse health effects. Beneficial health effects of any kind were specifically associated only with omega-3 fatty acids found in fish. Conclusions These findings highlight the complexity of assessing and communicating information about multiple contaminant exposure from fish consumption. Communication regarding potential health benefits conferred by specific fish nutrients was minimal and focused primarily on omega-3 fatty acids. This overview suggests some lessons learned and highlights a lack of both clarity and consistency in providing the breadth of information that sensitive populations such as pregnant women need to make public health decisions about fish consumption during pregnancy. PMID:19079708

  2. Targeting protein-trafficking pathways alters melanoma treatment sensitivity

    PubMed Central

    Huang, Zhi-ming; Chinen, Milka; Chang, Philip J.; Xie, Tong; Zhong, Lily; Demetriou, Stephanie; Patel, Mira P.; Scherzer, Rebecca; Sviderskaya, Elena V.; Bennett, Dorothy C.; Millhauser, Glenn L.; Oh, Dennis H.; Cleaver, James E.; Wei, Maria L.

    2012-01-01

    Protein-trafficking pathways are targeted here in human melanoma cells using methods independent of oncogene mutational status, and the ability to up-regulate and down-regulate tumor treatment sensitivity is demonstrated. Sensitivity of melanoma cells to cis-diaminedichloroplatinum II (cDDP, cis-platin), carboplatin, dacarbazine, or temozolomide together with velaparib, an inhibitor of poly (ADP ribose) polymerase 1, is increased by up to 10-fold by targeting genes that regulate both protein trafficking and the formation of melanosomes, intracellular organelles unique to melanocytes and melanoma cells. Melanoma cells depleted of either of the protein-trafficking regulators vacuolar protein sorting 33A protein (VPS33A) or cappuccino protein (CNO) have increased nuclear localization of cDDP, increased nuclear DNA damage by platination, and increased apoptosis, resulting in increased treatment sensitivity. Depleted cells also exhibit a decreased proportion of intracellular, mature melanosomes compared with undepleted cells. Modulation of protein trafficking via cell-surface signaling by binding the melanocortin 1 receptor with the antagonist agouti-signaling protein decreased the proportion of mature melanosomes formed and increased cDDP sensitivity, whereas receptor binding with the agonist melanocyte-stimulating hormone resulted in an increased proportion of mature melanosomes formed and in decreased sensitivity (i.e., increased resistance) to cDDP. Mutation of the protein-trafficking gene Hps6, known to impair the formation of mature melanosomes, also increased cDDP sensitivity. Together, these results indicate that targeting protein-trafficking molecules markedly increases melanoma treatment sensitivity and influences the degree of melanosomes available for sequestration of therapeutic agents. PMID:22203954

  3. Hearing sensitivity during target presence and absence while a whale echolocates.

    PubMed

    Supin, Alexander Ya; Nachtigall, Paul E; Breese, Marlee

    2008-01-01

    Hearing sensitivity was measured in a false killer whale during echolocation. Sensitivity was measured using probe stimuli as sinusoidally amplitude modulated signals with a 22.5-kHz carrier frequency and recording auditory evoked potentials as envelope-following responses. The probes were presented and responses were recorded during short 2-s periods when the animal echolocated to detect the presence or absence of a target in a go/no-go paradigm. In the target-absent trials, a hearing threshold of 90.4 dB re 1 muPa was found; in the target-present trials, the threshold was 109.8 dB. Thus, a 19.4-dB difference was found between thresholds in the target-present and target-absent trials. To check the possibility that this difference was the result of different masking degree of the probe by the emitted sonar clicks, click statistics were investigated in similar trials. No indication was found that the energy of the emitted clicks was higher in the target-present than in target-absent trials; on the contrary, mean click level, mean number of clicks per train, and overall train energy was slightly higher in the target-absent trials. Thus the data indicate that the hearing sensitivity of the whale varied depending on target presence or absence.

  4. Need for Improved Risk Communication of Fish Consumption Advisories to Protect Maternal and Child Health: Influence of Primary Informants

    PubMed Central

    LePrevost, Catherine E.; Gray, Kathleen M.; Hernández-Pelletier, Mercedes; Bouma, Brennan D.; Arellano, Consuelo; Cope, W. Gregory

    2013-01-01

    Fish consumption has established benefits, including the promotion of cardiovascular health and pre- and neonatal brain and eye development, but local freshwater fish may be a source of contaminants that are especially harmful to fetuses and young children, such as the neurotoxic and developmentally toxic methylmercury and polychlorinated biphenyls. Fish consumption advisories may be issued by state health departments to limit human exposure to these and other toxicants. This study examined the efficacy of a sign designed by the North Carolina Division of Public Health that was posted along a reservoir (Badin Lake) in central North Carolina, USA, for increasing anglers’ awareness of a fish consumption advisory, with a special focus on anglers who share their catch with women and children. In this study, 109 anglers were interviewed about their awareness of fish consumption advisories in general and their knowledge of the Badin Lake fish advisory in particular. Shore anglers were significantly less likely to be aware of the term “fish consumption advisory” and of the specific advisory for Badin Lake than boat anglers. Although a significant increase in knowledge of the specific fish consumption advisory was found for the entire sample of study participants after the sign intervention, a commensurate increase in knowledge was not found for a subsample of anglers who reported sharing their catch with women and children. Study findings underscore differences in fish consumption advisory awareness among subpopulations. Specifically, the study revealed the importance of characterizing the communication needs of shore anglers and anglers who share their catch with sensitive subpopulations (e.g., women and children) for the creation of more targeted communications of fish consumption advisories. PMID:23629591

  5. Auditing audits: use and development of the Oxfordshire Medical Audit Advisory Group rating system.

    PubMed Central

    Lawrence, M.; Griew, K.; Derry, J.; Anderson, J.; Humphreys, J.

    1994-01-01

    OBJECTIVES--To assess the value of the Oxfordshire Medical Audit Advisory Group rating system in monitoring and stimulating audit activity, and to implement a development of the system. DESIGN--Use of the rating system for assessment of practice audits on three annual visits in Oxfordshire; development and use of an "audit grid" as a refinement of the system; questionnaire to all medical audit advisory groups in England and Wales. SETTING--All 85 general practices in Oxfordshire; all 95 medical audit advisory groups in England and Wales. MAIN OUTCOME MEASURES--Level of practices' audit activity as measured by rating scale and grid. Use of scale nationally together with perceptions of strengths and weaknesses as perceived by chairs of medical audit advisory groups. RESULTS--After one year Oxfordshire practices more than attained the target standards set in 1991, with 72% doing audit involving setting target standards or implementing change; by 1993 this had risen to 78%. Most audits were confined to chronic disease management, preventive care, and appointments. 38 of 92 medical audit advisory groups used the Oxfordshire group's rating scale. Its main weaknesses were insensitivity in assessing the quality of audits and failure to measure team involvement. CONCLUSIONS--The rating system is effective educationally in helping practices improve and summatively for providing feedback to family health service authorities. The grid showed up weakness in the breadth of audit topics studied. IMPLICATIONS AND ACTION--Oxfordshire practices achieved targets set for 1991-2 but need to broaden the scope of their audits and the topics studied. The advisory group's targets for 1994-5 are for 50% of practices to achieve an audit in each of the areas of clinical care, access, communication, and professional values and for 80% of audits to include setting targets or implementing change. PMID:8086911

  6. Secure FAST: Security Enhancement in the NATO Time Sensitive Targeting Tool

    DTIC Science & Technology

    2010-11-01

    designed to aid in the tracking and prosecuting of Time Sensitive Targets. The FAST tool provides user level authentication and authorisation in terms...level authentication and authorisation in terms of security. It uses operating system level security but does not provide application level security for...and collaboration tool, designed to aid in the tracking and prosecuting of Time Sensitive Targets. The FAST tool provides user level authentication and

  7. 77 FR 30289 - Federal Advisory Committee Act; Technological Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-22

    ... FEDERAL COMMUNICATIONS COMMISSION Federal Advisory Committee Act; Technological Advisory Council... Communications Commission's (FCC) Technological Advisory Council will hold a meeting on Wednesday, June 27, 2012... INFORMATION: The FCC Technological Advisory Council proposed a new work agenda for the [[Page 30290

  8. Evaluating risk communication: examining target audience perceptions about four presentation formats for fish consumption health advisory information.

    PubMed

    Connelly, N A; Knuth, B A

    1998-10-01

    Information format can influence the extent to which target audiences understand and respond to risk-related information. This study examined four elements of risk information presentation format. Using printed materials, we examined target audience perceptions about: (a) reading level; (b) use of diagrams vs. text; (c) commanding versus cajoling tone; and (d) use of qualitative vs. quantitative information presented in a risk ladder. We used the risk communication topic of human health concerns related to eating noncommercial Great Lakes fish affected by chemical contaminants. Results from the comparisons of specific communication formats indicated that multiple formats are required to meet the needs of a significant percent of anglers for three of the four format types examined. Advisory text should be reviewed to ensure the reading level is geared to abilities of the target audience. For many audiences, a combination of qualitative and quantitative information, and a combination of diagrams and text may be most effective. For most audiences, a cajoling rather than commanding tone better provides them with the information they need to make a decision about fish consumption. Segmenting audiences regarding information needs and communication formats may help clarify which approaches to take with each audience.

  9. Provisional Advisory Levels (PALs) for Hazardous Agents ...

    EPA Pesticide Factsheets

    Technical Brief PROVISIONAL ADVISORY LEVELS. Few health-based guidelines are available to inform decisions regarding the reoccupation of buildings or sites, or the re-use of water resources, following their contamination through the accidental or intentional release of toxic chemicals or chemical warfare agents, or following a large-scale disaster. To address this need, EPA/ORD’s National Homeland Security Research Center (NHSRC) develops health-based Provisional Advisory Levels (PALs) for high priority chemicals including toxic industrial chemicals and chemical warfare agents, for both inhalation and oral exposures. Oral PALs are targeted to drinking water ingestion, but are applicable to other oral exposures such as soil ingestion. This product will be used as a hand-out at professional meetings to promote awareness of NHSRC's Provisional Advisory values. It will be posted on the intra and internet sites describing activities and products of EPA/ORD/NHSRC.

  10. Long-Term Memories Bias Sensitivity and Target Selection in Complex Scenes

    PubMed Central

    Patai, Eva Zita; Doallo, Sonia; Nobre, Anna Christina

    2014-01-01

    In everyday situations we often rely on our memories to find what we are looking for in our cluttered environment. Recently, we developed a new experimental paradigm to investigate how long-term memory (LTM) can guide attention, and showed how the pre-exposure to a complex scene in which a target location had been learned facilitated the detection of the transient appearance of the target at the remembered location (Summerfield, Lepsien, Gitelman, Mesulam, & Nobre, 2006; Summerfield, Rao, Garside, & Nobre, 2011). The present study extends these findings by investigating whether and how LTM can enhance perceptual sensitivity to identify targets occurring within their complex scene context. Behavioral measures showed superior perceptual sensitivity (d′) for targets located in remembered spatial contexts. We used the N2pc event-related potential to test whether LTM modulated the process of selecting the target from its scene context. Surprisingly, in contrast to effects of visual spatial cues or implicit contextual cueing, LTM for target locations significantly attenuated the N2pc potential. We propose that the mechanism by which these explicitly available LTMs facilitate perceptual identification of targets may differ from mechanisms triggered by other types of top-down sources of information. PMID:23016670

  11. Comparing phase-sensitive and phase-insensitive echolocation target images using a monaural audible sonar.

    PubMed

    Kuc, Roman

    2018-04-01

    This paper describes phase-sensitive and phase-insensitive processing of monaural echolocation waveforms to generate target maps. Composite waveforms containing both the emission and echoes are processed to estimate the target impulse response using an audible sonar. Phase-sensitive processing yields the composite signal envelope, while phase-insensitive processing that starts with the composite waveform power spectrum yields the envelope of the autocorrelation function. Analysis and experimental verification show that multiple echoes form an autocorrelation function that produces near-range phantom-reflector artifacts. These artifacts interfere with true target echoes when the first true echo occurs at a time that is less than the total duration of the target echoes. Initial comparison of phase-sensitive and phase-insensitive maps indicates that both display important target features, indicating that phase is not vital. A closer comparison illustrates the improved resolution of phase-sensitive processing, the near-range phantom-reflectors produced by phase-insensitive processing, and echo interference and multiple reflection artifacts that were independent of the processing.

  12. 76 FR 22395 - Federal Advisory Committee Act; Open Internet Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-21

    ... FEDERAL COMMUNICATIONS COMMISSION Federal Advisory Committee Act; Open Internet Advisory Committee... Advisory Committee, known as the ``Open Internet Advisory Committee'' (hereinafter ``the Committee''), is... effects of the FCC's Open Internet rules (available at http://www.fcc.gov/Daily_Releases/Daily_Business...

  13. 75 FR 8310 - Federal Advisory Committee; Transformation Advisory Group; Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Transformation Advisory... announces that the Transformation Advisory Group will hold a closed meeting on March 11, 2010. DATES: The... written statements to the membership of the Transformation Advisory Group at any time or in response to...

  14. 78 FR 51191 - Government-wide Travel Advisory Committee (GTAC); Public Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-20

    ...] Government-wide Travel Advisory Committee (GTAC); Public Advisory Committee Meeting AGENCY: Office of... Travel Advisory Committee (GTAC) (the Committee), is a Federal Advisory Committee established in...: Ms. Marcerto Barr, Designated Federal Officer (DFO), Government-wide Travel Advisory Committee (GTAC...

  15. Hyaluronic acid modified pH-sensitive liposomes for targeted intracellular delivery of doxorubicin.

    PubMed

    Paliwal, Shivani Rai; Paliwal, Rishi; Agrawal, Govind Prasad; Vyas, Suresh Prasad

    2016-12-01

    Surface-modified pH-sensitive liposomal system may be useful for intracellular delivery of chemotherapeutics. Achieving site-specific targeting with over-expressed hyaluronic acid (HA) receptors along with using pH sensitive liposome carrier for intracellular drug delivery was the aim of this study. Stealth HA-targeted pH-sensitive liposomes (SL-pH-HA) were developed and evaluated to achieve effective intracellular delivery of doxorubicin (DOX) vis-a-vis enhanced antitumor activity. The in vitro release studies demonstrated that the release of DOX from SL-pH-HA was pH-dependent, i.e. faster at mildly acidic pH ∼5, compared to physiological pH ∼7.4. SLpH-HA was evaluated for their cytotoxicity potential on CD44 receptor expressing MCF-7 cells. The half maximal inhibitory concentration (IC50) of SL-pH-HA and SL-HA were about 1.9 and 2.5 μM, respectively, after 48 h of incubation. The quantitative uptake study revealed higher localization of targeted liposomes in the receptor positive cells, which was further confirmed by fluorescent microscopy. The antitumor efficacy of the DOX-loaded HA-targeted pH-sensitive liposomes was also verified in a tumor xenograft mouse model. DOX was efficiently delivered to the tumor site by active targeting via HA and CD44 receptor interaction. The major side-effect of conventional DOX formulation, i.e. cardiotoxicity was also estimated by measuring serum enzyme levels of LDH and CPK and found to be minimized with developed formulation. Overall, HA targeted pH-sensitive liposomes were significantly more potent than the non-targeted liposomes in cells expressing high levels of CD44. Results strongly implies the promise of such liposomal system as an intracellular drug delivery carrier developed for potential anticancer treatment.

  16. Targeting Breast Cancer Recurrence via Hedgehog-mediated Sensitization of Breast Cancer Stem Cells

    DTIC Science & Technology

    2011-07-01

    Hedgehog -mediated Sensitization of Breast Cancer Stem Cells PRINCIPAL INVESTIGATOR: David J. Robbins, Ph.D...June 2010 – 14 June 2011 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Targeting Breast Cancer Recurrence via Hedgehog -mediated Sensitization of...this award. Introduction The purpose of the research supported by this award is to determine if targeting the hedgehog signaling pathway in

  17. Folate-containing reduction-sensitive lipid-polymer hybrid nanoparticles for targeted delivery of doxorubicin.

    PubMed

    Wu, Bo; Yu, Ping; Cui, Can; Wu, Ming; Zhang, Yang; Liu, Lei; Wang, Cai-Xia; Zhuo, Ren-Xi; Huang, Shi-Wen

    2015-04-01

    The development and evaluation of folate-targeted and reduction-triggered biodegradable nanoparticles are introduced to the research on targeted delivery of doxorubicin (DOX). This type of folate-targeted lipid-polymer hybrid nanoparticles (FLPNPs) is comprised of a poly(D,L-lactide-co-glycolide) (PLGA) core, a soybean lecithin monolayer, a monomethoxy-poly(ethylene glycol)-S-S-hexadecyl (mPEG-S-S-C16) reduction-sensitive shell, and a folic acid-targeted ligand. FLPNPs exhibited high size stability but fast disassembly in a simulated cancer cell reductive environment. The experiments on the release process in vitro revealed that as a reduction-sensitive drug delivery system, FLPNPs released DOX faster in the presence of 10 mM dithiothreitol (DTT). Results from flow cytometry, confocal image and in vitro cytotoxicity assays revealed that FLPNPs further enhanced cell uptake and generated higher cytotoxicity against human epidermoid carcinoma in the oral cavity than non-targeted redox-sensitive and targeted redox-insensitive controls. Furthermore, in vivo animal experiments demonstrated that systemic administration of DOX-loaded FLPNPs remarkably reduced tumor growth. Experiments on biodistribution of DOX-loaded FLPNPs showed that an increasing amount of DOX accumulated in the tumor. Therefore, FLPNPs formulations have proved to be a stable, controllable and targeted anticancer drug delivery system.

  18. 76 FR 71033 - Federal Advisory Committee Act; Technological Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-16

    ... FEDERAL COMMUNICATIONS COMMISSION Federal Advisory Committee Act; Technological Advisory Council... Communications Commission's (FCC) Technological Advisory Council will hold a meeting on Tuesday, December 20... in progress and discuss potential agendas for the coming year. The FCC will attempt to accommodate as...

  19. A Sensitive TLRH Targeted Imaging Technique for Ultrasonic Molecular Imaging

    PubMed Central

    Hu, Xiaowen; Zheng, Hairong; Kruse, Dustin E.; Sutcliffe, Patrick; Stephens, Douglas N.; Ferrara, Katherine W.

    2010-01-01

    The primary goals of ultrasound molecular imaging are the detection and imaging of ultrasound contrast agents (microbubbles), which are bound to specific vascular surface receptors. Imaging methods that can sensitively and selectively detect and distinguish bound microbubbles from freely circulating microbubbles (free microbubbles) and surrounding tissue are critically important for the practical application of ultrasound contrast molecular imaging. Microbubbles excited by low frequency acoustic pulses emit wide-band echoes with a bandwidth extending beyond 20 MHz; we refer to this technique as TLRH (transmission at a low frequency and reception at a high frequency). Using this wideband, transient echo, we have developed and implemented a targeted imaging technique incorporating a multi-frequency co-linear array and the Siemens Antares® imaging system. The multi-frequency co-linear array integrates a center 5.4 MHz array, used to receive echoes and produce radiation force, and two outer 1.5 MHz arrays used to transmit low frequency incident pulses. The targeted imaging technique makes use of an acoustic radiation force sub-sequence to enhance accumulation and a TLRH imaging sub-sequence to detect bound microbubbles. The radiofrequency (RF) data obtained from the TLRH imaging sub-sequence are processsed to separate echo signatures between tissue, free microbubbles, and bound microbubbles. By imaging biotin-coated microbubbles targeted to avidin-coated cellulose tubes, we demonstrate that the proposed method has a high contrast-to-tissue ratio (up to 34 dB) and a high sensitivity to bound microbubbles (with the ratio of echoes from bound microbubbles versus free microbubbles extending up to 23 dB). The effects of the imaging pulse acoustic pressure, the radiation force sub-sequence and the use of various slow-time filters on the targeted imaging quality are studied. The TLRH targeted imaging method is demonstrated in this study to provide sensitive and selective

  20. Great Lakes fish consumption advisories: is mercury a concern?

    PubMed

    Bhavsar, Satyendra P; Awad, Emily; Mahon, Chris G; Petro, Steve

    2011-10-01

    The majority of the restrictive fish consumption advisories for the Canadian waters of the Great Lakes issued by the Ontario Ministry of the Environment, Canada based on the most restrictive contaminant, are attributed to polychlorinated biphenyls (PCBs) and dioxins/furans. Mercury currently causes about <1-2.5% and 9-16% of the restrictive advisories for the general population (GP) and sensitive population of children under 15 and women of child-bearing age (SP), respectively (the St. Lawrence River is not considered here). Toxaphene causes minor restrictions. At present it is not clear that if PCBs and dioxins/furans were to decrease below their fish consumption advisory guidelines, current fish mercury levels would replace some, most or all of the consumption restrictions. In order to examine this, location-, species- and size-specific fish consumption advisories were calculated for a "mercury only" scenario by disregarding the presence of the other contaminants. In the absence of other contaminants, mercury would replace some of the current advisories caused by other contaminants; however, the overall advisories would be minimally to moderately restrictive (<1-7% for GP; 13-32% for SP). Almost half of the Great Lake blocks considered here would have more than double the unrestricted consumption advisories than they currently have, with Lake Ontario showing the greatest improvement. Certain size ranges of each species across the main basins of the Canadian waters of the Great Lakes would be deemed safe for unrestricted consumption. However, at least some sizes of a number of species from certain locations of each lake would still have "do not eat" advisories issued for the SP, although these restrictions would be minimal for Lake Erie. These results suggest that the current mercury levels in the Canadian Great Lakes fish are of very minor concern for the GP and of moderate concern for the SP.

  1. 78 FR 69991 - Advisory Committee; Veterinary Medicine Advisory Committee; Termination

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-22

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 14 [Docket No. FDA-2013-N-1380] Advisory Committee; Veterinary Medicine Advisory Committee; Termination AGENCY: Food... announcing the termination of the Veterinary Medicine Advisory Committee. This document removes the...

  2. 75 FR 43156 - Federal Advisory Committee; Missile Defense Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-23

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Missile Defense Advisory Committee AGENCY: Missile Defense Agency (MDA), DoD. ACTION: Notice of closed meeting. SUMMARY: Under the... Defense announces that the Missile Defense Advisory Committee will meet on August 4 and 5, 2010, in...

  3. Differential Sensitivity of Target Genes to Translational Repression by miR-17~92

    PubMed Central

    Jin, Hyun Yong; Oda, Hiroyo; Chen, Pengda; Kang, Seung Goo; Valentine, Elizabeth; Liao, Lujian; Zhang, Yaoyang; Gonzalez-Martin, Alicia; Shepherd, Jovan; Head, Steven R.; Kim, Pyeung-Hyeun; Fu, Guo; Liu, Wen-Hsien; Han, Jiahuai

    2017-01-01

    MicroRNAs (miRNAs) are thought to exert their functions by modulating the expression of hundreds of target genes and each to a small degree, but it remains unclear how small changes in hundreds of target genes are translated into the specific function of a miRNA. Here, we conducted an integrated analysis of transcriptome and translatome of primary B cells from mutant mice expressing miR-17~92 at three different levels to address this issue. We found that target genes exhibit differential sensitivity to miRNA suppression and that only a small fraction of target genes are actually suppressed by a given concentration of miRNA under physiological conditions. Transgenic expression and deletion of the same miRNA gene regulate largely distinct sets of target genes. miR-17~92 controls target gene expression mainly through translational repression and 5’UTR plays an important role in regulating target gene sensitivity to miRNA suppression. These findings provide molecular insights into a model in which miRNAs exert their specific functions through a small number of key target genes. PMID:28241004

  4. Sensitizing Black Adult and Youth Consumers to Targeted Food Marketing Tactics in Their Environments

    PubMed Central

    Isselmann DiSantis, Katherine; Kumanyika, Shiriki; Rohm Young, Deborah; Grier, Sonya A.; Lassiter, Vikki

    2017-01-01

    Food marketing environments of Black American consumers are heavily affected by ethnically-targeted marketing of sugar sweetened beverages, fast foods, and other products that may contribute to caloric overconsumption. This qualitative study assessed Black consumers’ responses to targeted marketing. Black adults (2 mixed gender groups; total n = 30) and youth (2 gender specific groups; total n = 35) from two U.S. communities participated before and after a sensitization procedure—a critical practice used to understand social justice concerns. Pre-sensitization focus groups elicited responses to scenarios about various targeted marketing tactics. Participants were then given an informational booklet about targeted marketing to Black Americans, and all returned for the second (post-sensitization) focus group one week later. Conventional qualitative content analysis of transcripts identified several salient themes: seeing the marketer’s perspective (“it’s about demand”; “consumers choose”), respect for community (“marketers are setting us up for failure”; “making wrong assumptions”), and food environments as a social justice issue (“no one is watching the door”; “I didn’t realize”). Effects of sensitization were reflected in participants’ stated reactions to the information in the booklet, and also in the relative occurrence of marketer-oriented themes and social justice-oriented themes, respectively, less and more after sensitization. PMID:29109377

  5. Sensitizing Black Adult and Youth Consumers to Targeted Food Marketing Tactics in Their Environments.

    PubMed

    Isselmann DiSantis, Katherine; Kumanyika, Shiriki; Carter-Edwards, Lori; Rohm Young, Deborah; Grier, Sonya A; Lassiter, Vikki

    2017-10-29

    Food marketing environments of Black American consumers are heavily affected by ethnically-targeted marketing of sugar sweetened beverages, fast foods, and other products that may contribute to caloric overconsumption. This qualitative study assessed Black consumers' responses to targeted marketing. Black adults (2 mixed gender groups; total n = 30) and youth (2 gender specific groups; total n = 35) from two U.S. communities participated before and after a sensitization procedure-a critical practice used to understand social justice concerns. Pre-sensitization focus groups elicited responses to scenarios about various targeted marketing tactics. Participants were then given an informational booklet about targeted marketing to Black Americans, and all returned for the second (post-sensitization) focus group one week later. Conventional qualitative content analysis of transcripts identified several salient themes: seeing the marketer's perspective ("it's about demand"; "consumers choose"), respect for community ("marketers are setting us up for failure"; "making wrong assumptions"), and food environments as a social justice issue ("no one is watching the door"; "I didn't realize"). Effects of sensitization were reflected in participants' stated reactions to the information in the booklet, and also in the relative occurrence of marketer-oriented themes and social justice-oriented themes, respectively, less and more after sensitization.

  6. Advancing the sensitivity of selected reaction monitoring-based targeted quantitative proteomics

    PubMed Central

    Shi, Tujin; Su, Dian; Liu, Tao; Tang, Keqi; Camp, David G.; Qian, Wei-Jun; Smith, Richard D.

    2012-01-01

    Selected reaction monitoring (SRM)—also known as multiple reaction monitoring (MRM)—has emerged as a promising high-throughput targeted protein quantification technology for candidate biomarker verification and systems biology applications. A major bottleneck for current SRM technology, however, is insufficient sensitivity for e.g., detecting low-abundance biomarkers likely present at the low ng/mL to pg/mL range in human blood plasma or serum, or extremely low-abundance signaling proteins in cells or tissues. Herein we review recent advances in methods and technologies, including front-end immunoaffinity depletion, fractionation, selective enrichment of target proteins/peptides including posttranslational modifications (PTMs), as well as advances in MS instrumentation which have significantly enhanced the overall sensitivity of SRM assays and enabled the detection of low-abundance proteins at low to sub- ng/mL level in human blood plasma or serum. General perspectives on the potential of achieving sufficient sensitivity for detection of pg/mL level proteins in plasma are also discussed. PMID:22577010

  7. 76 FR 52319 - Federal Advisory Committee Meeting Notice; Threat Reduction Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-22

    ... DEPARTMENT OF DEFENSE Federal Advisory Committee Meeting Notice; Threat Reduction Advisory... committee meeting of the Threat Reduction Advisory Committee (Hereafter referred to as ``the Committee... CONTACT: Mr. William Hostyn, Defense Threat Reduction Agency/SP-ACP, 8725 John J. Kingman Road, MS 6201...

  8. 77 FR 12841 - The President's Management Advisory Board (PMAB); Notification of Upcoming Public Advisory Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-02

    ... recommendations aimed at improving Information Technology (IT) portfolio and project management, IT vendor... President's Management Advisory Board (PMAB); Notification of Upcoming Public Advisory Meeting AGENCY...: The President's Management Advisory Board (PMAB), a Federal Advisory Committee established in...

  9. Advancing the sensitivity of selected reaction monitoring-based targeted quantitative proteomics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shi, Tujin; Su, Dian; Liu, Tao

    2012-04-01

    Selected reaction monitoring (SRM)—also known as multiple reaction monitoring (MRM)—has emerged as a promising high-throughput targeted protein quantification technology for candidate biomarker verification and systems biology applications. A major bottleneck for current SRM technology, however, is insufficient sensitivity for e.g., detecting low-abundance biomarkers likely present at the pg/mL to low ng/mL range in human blood plasma or serum, or extremely low-abundance signaling proteins in the cells or tissues. Herein we review recent advances in methods and technologies, including front-end immunoaffinity depletion, fractionation, selective enrichment of target proteins/peptides or their posttranslational modifications (PTMs), as well as advances in MS instrumentation, whichmore » have significantly enhanced the overall sensitivity of SRM assays and enabled the detection of low-abundance proteins at low to sub- ng/mL level in human blood plasma or serum. General perspectives on the potential of achieving sufficient sensitivity for detection of pg/mL level proteins in plasma are also discussed.« less

  10. [Advances of tumor targeting peptides drug delivery system with pH-sensitive activities].

    PubMed

    Ma, Yin-yun; Li, Li; Huang, Hai-feng; Gou, San-hu; Ni, Jing-man

    2016-05-01

    The pH-sensitive peptides drug delivery systems, which target to acidic extracellular environment of tumor tissue, have many advantages in drug delivery. They exhibit a high specificity to tumor and low cytotoxicity, which significantly increase the efficacy of traditional anti-cancer drugs. In recent years the systems have received a great attention. The pH-sensitive peptides drug delivery systems can be divided into five types according to the difference in pH-responsive mechanism,type of peptides and carrier materials. This paper summarizes the recent progresses in the field with a focus on the five types of pH-sensitive peptides in drug delivery systems. This may provide a guideline to design and application of tumor targeting drugs.

  11. 76 FR 65511 - The President's Management Advisory Board (PMAB); Notification of Upcoming Public Advisory Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-21

    ... management and operation, with a particular focus on productivity and the application of technology. Agenda... President's Management Advisory Board (PMAB); Notification of Upcoming Public Advisory Meeting AGENCY...: The President's Management Advisory Board (PMAB), a Federal Advisory Committee established in...

  12. 78 FR 40144 - Governmentwide Travel Advisory Committee (GTAC); Upcoming Public Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-03

    ...] Governmentwide Travel Advisory Committee (GTAC); Upcoming Public Advisory Committee Meeting AGENCY: Office of Governmentwide Policy, General Services Administration (GSA). ACTION: Notice. SUMMARY: The Governmentwide Travel... Officer (DFO), Governmentwide Travel Advisory Committee (GTAC), Office of Governmentwide Policy, General...

  13. 77 FR 38065 - The President's Management Advisory Board (PMAB); Notification of Upcoming Public Advisory Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-26

    ... President's Management Advisory Board (PMAB); Notification of Upcoming Public Advisory Meeting AGENCY...: The President's Management Advisory Board (PMAB), a Federal Advisory Committee established in...: The meeting will be held on Wednesday, July 11, 2012, beginning at 9 a.m. eastern time, ending no...

  14. 75 FR 81245 - Federal Advisory Committee; Defense Intelligence Agency Advisory Board; Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-27

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Defense Intelligence Agency Advisory Board; Closed Meeting AGENCY: Defense Intelligence Agency, DoD. ACTION: Notice. SUMMARY... Defense announces that Defense Intelligence Agency Advisory Board and two of its subcommittees will meet...

  15. 75 FR 24926 - Federal Advisory Committee; Defense Intelligence Agency Advisory Board; Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-06

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Defense Intelligence Agency Advisory Board; Closed Meeting AGENCY: Defense Intelligence Agency, DoD. ACTION: Meeting notice... Department of Defense announces that Defense Intelligence Agency Advisory Board, and its subcommittees, will...

  16. 76 FR 41220 - Federal Advisory Committee; Defense Intelligence Agency Advisory Board; Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-13

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Defense Intelligence Agency Advisory Board; Closed Meeting AGENCY: Defense Intelligence Agency, DoD. ACTION: Meeting notice... Department of Defense announces that Defense Intelligence Agency Advisory Board and two of its subcommittees...

  17. 78 FR 60863 - Threat Reduction Advisory Committee; Notice of Federal Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ... DEPARTMENT OF DEFENSE Office of the Secretary Threat Reduction Advisory Committee; Notice of... Defense announces the following Federal advisory committee meeting of the Threat Reduction Advisory... Springs, CO. FOR FURTHER INFORMATION CONTACT: Mr. William Hostyn, DoD, Defense Threat Reduction Agency/J2...

  18. 78 FR 29334 - Threat Reduction Advisory Committee; Notice of Federal Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-20

    ... DEPARTMENT OF DEFENSE Office of the Secretary Threat Reduction Advisory Committee; Notice of... Defense announces the following Federal advisory committee meeting of the Threat Reduction Advisory..., CO. FOR FURTHER INFORMATION CONTACT: Mr. William Hostyn, DoD, Defense Threat Reduction Agency/J2/5/8R...

  19. 77 FR 2710 - Threat Reduction Advisory Committee; Notice of Federal Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-19

    ... DEPARTMENT OF DEFENSE Office of the Secretary Threat Reduction Advisory Committee; Notice of... following Federal advisory committee meeting of the Threat Reduction Advisory Committee (hereafter referred... CONTACT: Mr. William Hostyn, GS-15, DoD, Defense Threat Reduction Agency/SP-ACP, 8725 John J. Kingman Road...

  20. 75 FR 37410 - Federal Advisory Committee; Defense Advisory Committee on Military Personnel Testing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-29

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Defense Advisory Committee on Military Personnel Testing AGENCY: Under Secretary of Defense for Personnel and Readiness, DoD...), and 41 CFR 102-3.150, DoD announces that the Defense Advisory Committee on Military Personnel Testing...

  1. 75 FR 63823 - Federal Advisory Committee; Defense Advisory Committee on Military Personnel Testing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-18

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Defense Advisory...), and 41 CFR 102-3.150, the Department of Defense announces that the Defense Advisory Committee on... OSD Federal Register Liaison Officer, Department of Defense. [FR Doc. 2010-26189 Filed 10-15-10; 8:45...

  2. 77 FR 19006 - Threat Reduction Advisory Committee; Notice of Federal Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-29

    ... DEPARTMENT OF DEFENSE Office of the Secretary Threat Reduction Advisory Committee; Notice of... advisory committee meeting of the Threat Reduction Advisory Committee (hereafter referred to as ``the.... William Hostyn, GS-15, DoD, Defense Threat Reduction Agency/SP-ACP, 8725 John J. Kingman Road, MS 6201...

  3. 77 FR 50088 - Threat Reduction Advisory Committee; Notice of Federal Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-20

    ... DEPARTMENT OF DEFENSE Office of the Secretary Threat Reduction Advisory Committee; Notice of... following Federal advisory committee meeting of the Threat Reduction Advisory Committee (hereafter referred... INFORMATION CONTACT: Mr. William Hostyn, GS-15, DoD, Defense Threat Reduction Agency/J2/5/8R, 8725 John J...

  4. 77 FR 69807 - Threat Reduction Advisory Committee; Notice of Federal Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-21

    ... DEPARTMENT OF DEFENSE Office of the Secretary Threat Reduction Advisory Committee; Notice of... following Federal advisory committee meeting of the Threat Reduction Advisory Committee (hereafter referred... INFORMATION CONTACT: Mr. William Hostyn, DoD, Defense Threat Reduction Agency/J2/5/8R-ACP, 8725 John J...

  5. 76 FR 52016 - NASA International Space Station Advisory Committee and the Aerospace Safety Advisory Panel; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-19

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (11-074)] NASA International Space Station Advisory Committee and the Aerospace Safety Advisory Panel; Meeting AGENCY: National Aeronautics and Space... meeting of the NASA International Space Station Advisory Committee and the Aerospace Safety Advisory Panel...

  6. 77 FR 55863 - NASA Advisory Council; Science Committee; Earth Science Subcommittee; Applied Sciences Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-11

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (12-072)] NASA Advisory Council; Science Committee; Earth Science Subcommittee; Applied Sciences Advisory Group Meeting AGENCY: National Aeronautics... the Applied Science Advisory Group. This Subcommittee reports to the Earth Science Subcommittee...

  7. 77 FR 61581 - Notice of Advisory Committee Closed Meeting; U.S. Strategic Command Strategic Advisory Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-10

    .... Strategic Command Strategic Advisory Group AGENCY: Department of Defense. ACTION: Notice of Advisory... advisory committee: U.S. Strategic Command Strategic Advisory Group. DATES: November 15, 2012, from 8 a.m... Command, during the development of the Nation's strategic war plans. Agenda: Topics include: Policy Issues...

  8. 78 FR 67131 - Notice of Advisory Committee Closed Meeting; U.S. Strategic Command Strategic Advisory Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    .... Strategic Command Strategic Advisory Group AGENCY: Department of Defense. ACTION: Notice of Advisory... following Federal Advisory Committee meeting of the U.S. Strategic Command Strategic Advisory Group. DATES... issues to the Commander, U.S. Strategic Command, during the development of the Nation's strategic war...

  9. 77 FR 46802 - National Emergency Medical Services Advisory Council (NEMSAC); Notice of Federal Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-06

    ...-0100] National Emergency Medical Services Advisory Council (NEMSAC); Notice of Federal Advisory... Transportation (DOT). ACTION: Meeting Notice--National Emergency Medical Services Advisory Council. SUMMARY: The... NEMSAC is to provide a nationally recognized council of emergency medical services representatives and...

  10. 78 FR 49332 - National Emergency Medical Services Advisory Council (NEMSAC); Notice of Federal Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-13

    ...-0091] National Emergency Medical Services Advisory Council (NEMSAC); Notice of Federal Advisory... Transportation (DOT). ACTION: Meeting Notice--National Emergency Medical Services Advisory Council. SUMMARY: The... emergency medical services representatives and consumers, is to advise and consult with DOT and the Federal...

  11. 75 FR 60484 - NASA Advisory Council; Science Committee; Earth Science Subcommittee; Applied Sciences Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-30

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (10-115)] NASA Advisory Council; Science Committee; Earth Science Subcommittee; Applied Sciences Advisory Group Meeting AGENCY: National Aeronautics...) announces a meeting of the Applied Science Advisory Group. This Subcommittee reports to the Earth Science...

  12. 76 FR 60811 - Notice of Advisory Committee Closed Meeting; U.S. Strategic Command Strategic Advisory Group...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-30

    ... DEPARTMENT OF DEFENSE Notice of Advisory Committee Closed Meeting; U.S. Strategic Command Strategic Advisory Group; Correction AGENCY: Department of Defense. ACTION: Notice of Advisory Committee... Command Strategic Advisory Group gave notice of a meeting to be held on November 1, 2011, from 8 a.m. to 5...

  13. 75 FR 60430 - Federal Advisory Committee; Threat Reduction Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-30

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Threat Reduction... amended) the Department of Defense announces a meeting of the Threat Reduction Advisory Committee... Wright, Defense Threat Reduction Agency/AST, 8725 John J. Kingman Road, MS 6201, Fort Belvoir, VA 22060...

  14. 78 FR 77443 - Electricity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-23

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee AGENCY: Office of Electricity Delivery and... announces a meeting of the Electricity Advisory Committee (EAC). The Federal Advisory Committee Act (Pub. L... at: http://energy.gov/oe/services/electricity-advisory-committee-eac . FOR FURTHER INFORMATION...

  15. 75 FR 32469 - Consumer Advisory Council; Notice of Meeting of the Consumer Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-08

    ... FEDERAL RESERVE SYSTEM Consumer Advisory Council; Notice of Meeting of the Consumer Advisory Council The Consumer Advisory Council will meet on Thursday, June 17, 2010. The meeting, which will be...'s responsibilities under various consumer financial services laws and on other matters on which the...

  16. Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer

    PubMed Central

    Azorsa, David O; Gonzales, Irma M; Basu, Gargi D; Choudhary, Ashish; Arora, Shilpi; Bisanz, Kristen M; Kiefer, Jeffrey A; Henderson, Meredith C; Trent, Jeffrey M; Von Hoff, Daniel D; Mousses, Spyro

    2009-01-01

    Background Pancreatic cancer retains a poor prognosis among the gastrointestinal cancers. It affects 230,000 individuals worldwide, has a very high mortality rate, and remains one of the most challenging malignancies to treat successfully. Treatment with gemcitabine, the most widely used chemotherapeutic against pancreatic cancer, is not curative and resistance may occur. Combinations of gemcitabine with other chemotherapeutic drugs or biological agents have resulted in limited improvement. Methods In order to improve gemcitabine response in pancreatic cancer cells, we utilized a synthetic lethal RNAi screen targeting 572 known kinases to identify genes that when silenced would sensitize pancreatic cancer cells to gemcitabine. Results Results from the RNAi screens identified several genes that, when silenced, potentiated the growth inhibitory effects of gemcitabine in pancreatic cancer cells. The greatest potentiation was shown by siRNA targeting checkpoint kinase 1 (CHK1). Validation of the screening results was performed in MIA PaCa-2 and BxPC3 pancreatic cancer cells by examining the dose response of gemcitabine treatment in the presence of either CHK1 or CHK2 siRNA. These results showed a three to ten-fold decrease in the EC50 for CHK1 siRNA-treated cells versus control siRNA-treated cells while treatment with CHK2 siRNA resulted in no change compared to controls. CHK1 was further targeted with specific small molecule inhibitors SB 218078 and PD 407824 in combination with gemcitabine. Results showed that treatment of MIA PaCa-2 cells with either of the CHK1 inhibitors SB 218078 or PD 407824 led to sensitization of the pancreatic cancer cells to gemcitabine. Conclusion These findings demonstrate the effectiveness of synthetic lethal RNAi screening as a tool for identifying sensitizing targets to chemotherapeutic agents. These results also indicate that CHK1 could serve as a putative therapeutic target for sensitizing pancreatic cancer cells to gemcitabine. PMID

  17. 16 CFR 1018.26 - Advisory functions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Advisory functions. 1018.26 Section 1018.26 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ADVISORY COMMITTEE MANAGEMENT Operation of Advisory Committees § 1018.26 Advisory functions. (a) Unless otherwise specifically provided by statute...

  18. Perceptions of recreational fishing boat captains: knowledge and effects of fish consumption advisories.

    PubMed

    Burger, J; Johnson, B B; Shukla, S; Gochfeld, M

    2003-04-01

    The impacts of fish consumption advisories on recreational and subsistence fishing, particularly in fresh waters, have been examined extensively. By contrast, little attention has focused on organized recreational fishing, such as from party and charter boats, and particularly for salt water fish. We interviewed 93 New Jersey boat captains to determine their knowledge about fish consumption advisories, and whether, in their opinion, clients knew of fish consumption advisories, and whether they thought advisories had an effect on recreational fishing and their businesses. Advisories were ranked by captains as a moderate influence on the success of their business, less so than number of fish caught, strength of the economy, overfishing by commercial boats, and management regulations. Only one boat captain had not heard warnings about eating fish, but what captains said they had heard was mixed in its accuracy and completeness. Clients expect captains to know about fish, and about half of boat captains said clients had asked about the safety of eating fish. Captains who felt advisories were affecting their businesses tended to fish for species without high levels of mercury (except for bluefish) or PCBs, the primary contaminants of concern for state advisories and federal advice. However, these captains worked closer to areas (e.g., Raritan Bay complex and New York Harbor) subject to advisories than did other captains, and were more prone to say that management regulations (e.g., fish size, creel limits, seasons) and marketing and advertising by the industry or state were strong influences on the success of their seasons. Comparing captains who thought advisories had some or great effect (60%) versus those reporting "no effect" (40%), there was no difference in the mean percentage of trips targeting high mercury species such as swordfish and shark. Many captains said they would or might post advisories, but 42% of the boat captains said they would not post consumption

  19. 76 FR 29752 - The President's Management Advisory Board (PMAB); Notification of Upcoming Public Advisory Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-23

    ...The President's Management Advisory Board, a Federal Advisory Committee established in accordance with the Federal Advisory Committee Act (FACA), 5 U.S.C., App., and Executive Order 13538, will hold a public meeting on June 17, 2011.

  20. 75 FR 27557 - Federal Advisory Committee Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-17

    ... the charter for the Advisory Committee for the 2012 Radiocommunication Conference (WRC-12 Advisory Committee), for a two-year period. The WRC-12 Advisory Committee is a Federal advisory committee under the... CONTACT: Alexander Roytblat, Designated Federal Official, WRC-12 Advisory Committee, FCC International...

  1. 77 FR 69869 - National Advisory Council on Alcohol Abuse and Alcoholism, National Advisory Council on Drug...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-21

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Advisory Council on Alcohol Abuse and Alcoholism, National Advisory Council on Drug Abuse, and National Cancer Advisory Board; Notice of Joint Meeting Pursuant to section 10(a) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given o...

  2. Target-protecting dumbbell molecular probe against exonucleases digestion for sensitive detection of ATP and streptavidin.

    PubMed

    Chen, Jinyang; Liu, Yucheng; Ji, Xinghu; He, Zhike

    2016-09-15

    In this work, a versatile dumbbell molecular (DM) probe was designed and employed in the sensitively homogeneous bioassay. In the presence of target molecule, the DM probe was protected from the digestion of exonucleases. Subsequently, the protected DM probe specifically bound to the intercalation dye and resulted in obvious fluorescence signal which was used to determine the target molecule in return. This design allows specific and versatile detection of diverse targets with easy operation and no sophisticated fluorescence labeling. Integrating the idea of target-protecting DM probe with adenosine triphosphate (ATP) involved ligation reaction, the DM probe with 5'-end phosphorylation was successfully constructed for ATP detection, and the limitation of detection was found to be 4.8 pM. Thanks to its excellent selectivity and sensitivity, this sensing strategy was used to detect ATP spiked in human serum as well as cellular ATP. Moreover, the proposed strategy was also applied in the visual detection of ATP in droplet-based microfluidic platform with satisfactory results. Similarly, combining the principle of target-protecting DM probe with streptavidin (SA)-biotin interaction, the DM probe with 3'-end biotinylation was developed for selective and sensitive SA determination, which demonstrated the robustness and versatility of this design. Copyright © 2016 Elsevier B.V. All rights reserved.

  3. Twin target self-amplification-based DNA machine for highly sensitive detection of cancer-related gene.

    PubMed

    Xu, Huo; Jiang, Yifan; Liu, Dengyou; Liu, Kai; Zhang, Yafeng; Yu, Suhong; Shen, Zhifa; Wu, Zai-Sheng

    2018-06-29

    The sensitive detection of cancer-related genes is of great significance for early diagnosis and treatment of human cancers, and previous isothermal amplification sensing systems were often based on the reuse of target DNA, the amplification of enzymatic products and the accumulation of reporting probes. However, no reporting probes are able to be transformed into target species and in turn initiate the signal of other probes. Herein we reported a simple, isothermal and highly sensitive homogeneous assay system for tumor suppressor p53 gene detection based on a new autonomous DNA machine, where the signaling probe, molecular beacon (MB), was able to execute the function similar to target DNA besides providing the common signal. In the presence of target p53 gene, the operation of DNA machine can be initiated, and cyclical nucleic acid strand-displacement polymerization (CNDP) and nicking/polymerization cyclical amplification (NPCA) occur, during which the MB was opened by target species and cleaved by restriction endonuclease. In turn, the cleaved fragments could activate the next signaling process as target DNA did. According to the functional similarity, the cleaved fragment was called twin target, and the corresponding fashion to amplify the signal was named twin target self-amplification. Utilizing this newly-proposed DNA machine, the target DNA could be detected down to 0.1 pM with a wide dynamic range (6 orders of magnitude) and single-base mismatched targets were discriminated, indicating a very high assay sensitivity and good specificity. In addition, the DNA machine was not only used to screen the p53 gene in complex biological matrix but also was capable of practically detecting genomic DNA p53 extracted from A549 cell line. This indicates that the proposed DNA machine holds the potential application in biomedical research and early clinical diagnosis. Copyright © 2018 Elsevier B.V. All rights reserved.

  4. 75 FR 43493 - Office of the Secretary; Federal Advisory Committee; Defense Intelligence Agency Advisory Board...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-26

    ... DEPARTMENT OF DEFENSE Office of the Secretary; Federal Advisory Committee; Defense Intelligence Agency Advisory Board; Closed Meeting AGENCY: Defense Intelligence Agency, DOD. ACTION: Meeting notice... Department of Defense announces that Defense Intelligence Agency Advisory Board will meet on September 1 and...

  5. 75 FR 18824 - Federal Advisory Committee; Meeting of the Department of Defense Historical Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Meeting of the Department of Defense Historical Advisory Committee AGENCY: Department of Defense (DoD). ACTION: Notice of... notice announces a meeting of the Department of Defense Historical Advisory Committee. During the meeting...

  6. 78 FR 21349 - Defense Advisory Committee on Military Personnel Testing; Notice of Federal Advisory Committee...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-10

    ... DEPARTMENT OF DEFENSE Office of the Secretary Defense Advisory Committee on Military Personnel... advisory committee meeting of the Defense Advisory Committee on Military Personnel Testing will take place... meeting is to review planned changes and progress in developing computerized tests for military enlistment...

  7. Antigen sensitivity of CD22-specific chimeric TCR is modulated by target epitope distance from the cell membrane.

    PubMed

    James, Scott E; Greenberg, Philip D; Jensen, Michael C; Lin, Yukang; Wang, Jinjuan; Till, Brian G; Raubitschek, Andrew A; Forman, Stephen J; Press, Oliver W

    2008-05-15

    We have targeted CD22 as a novel tumor-associated Ag for recognition by human CTL genetically modified to express chimeric TCR (cTCR) recognizing this surface molecule. CD22-specific cTCR targeting different epitopes of the CD22 molecule promoted efficient lysis of target cells expressing high levels of CD22 with a maximum lytic potential that appeared to decrease as the distance of the target epitope from the target cell membrane increased. Targeting membrane-distal CD22 epitopes with cTCR(+) CTL revealed defects in both degranulation and lytic granule targeting. CD22-specific cTCR(+) CTL exhibited lower levels of maximum lysis and lower Ag sensitivity than CTL targeting CD20, which has a shorter extracellular domain than CD22. This diminished sensitivity was not a result of reduced avidity of Ag engagement, but instead reflected weaker signaling per triggered cTCR molecule when targeting membrane-distal epitopes of CD22. Both of these parameters were restored by targeting a ligand expressing the same epitope, but constructed as a truncated CD22 molecule to approximate the length of a TCR:peptide-MHC complex. The reduced sensitivity of CD22-specific cTCR(+) CTL for Ag-induced triggering of effector functions has potential therapeutic applications, because such cells selectively lysed B cell lymphoma lines expressing high levels of CD22, but demonstrated minimal activity against autologous normal B cells, which express lower levels of CD22. Thus, our results demonstrate that cTCR signal strength, and consequently Ag sensitivity, can be modulated by differential choice of target epitopes with respect to distance from the cell membrane, allowing discrimination between targets with disparate Ag density.

  8. Herceptin conjugated PLGA-PHis-PEG pH sensitive nanoparticles for targeted and controlled drug delivery.

    PubMed

    Zhou, Zilan; Badkas, Apurva; Stevenson, Max; Lee, Joo-Youp; Leung, Yuet-Kin

    2015-06-20

    A dual functional nano-scaled drug carrier, comprising of a targeting ligand and pH sensitivity, has been made in order to increase the specificity and efficacy of the drug delivery system. The nanoparticles are made of a tri-block copolymer, poly(d,l lactide-co-glycolide) (PLGA)-b-poly(l-histidine) (PHis)-b-polyethylene glycol (PEG), via nano-precipitation. To provide the nanoparticle feature of endolysosomal escape and pH sensitivity, poly(l-histidine) was chosen as a proton sponge polymer. Herceptin, which specifically binds to HER2 antigen, was conjugated to the nanoparticles through click chemistry. The nanoparticles were characterized via dynamic light scattering (DLS) and transmission electron microscopy (TEM). Both methods showed the sizes of about 100nm with a uniform size distribution. The pH sensitivity was assessed by drug releases and size changes at different pH conditions. As pH decreased from 7.4 to 5.2, the drug release rate accelerated and the size significantly increased. During in vitro tests against human breast cancer cell lines, MCF-7 and SK-BR-3 showed significantly increased uptake for Herceptin-conjugated nanoparticles, as compared to non-targeted nanoparticles. Herceptin-conjugated pH-sensitive nanoparticles showed the highest therapeutic effect, and thus validated the efficacy of a combined approach of pH sensitivity and active targeting. Copyright © 2015 Elsevier B.V. All rights reserved.

  9. Targeted two-photon PDT photo-sensitizers for the treatment of subcutaneous tumors

    NASA Astrophysics Data System (ADS)

    Spangler, C. W.; Rebane, A.; Starkey, J.; Drobizhev, M.

    2009-06-01

    New porphyrin-based photo-sensitizers have been designed, synthesized and characterized that exhibit greatly enhanced intrinsic two-photon absorption. These new photo-sensitizers have been incorporated into triad formulations that also incorporate Near-infrared (NIR) imaging agents, and small-molecule targeting agents that direct the triads to cancerous tumors' over-expressed receptor sites. PDT can be initiated deep into the tissue transparency window at 780-800 nm utilizing a regeneratively amplified Ti:sapphire laser using 100-150 fs pulses of 600-800 mW. Human tumor xenografts of human breast cancer (MDA-MB-231) and both small SCLC (NCI-H69) and NSCLC (A-459) have been successfully treated using octreotate targeting of over-expressed SST2 receptors. In particular, the lung cancer xenografts can be successfully treated by irradiating from the side of the mouse opposite the implanted tumor, thereby passing through ca. 2 cm of mouse skin, tissue and organs with no discernible damage to healthy tissue while causing regression in the tumors. These results suggest a new PDT paradigm for the noninvasive treatment of subcutaneous tumors, including the possibility that the targeting moiety could be matched to individual patient genetic profiles (patient-specific therapeutics).

  10. Novel targets for sensitizing breast cancer cells to TRAIL-induced apoptosis with siRNA delivery.

    PubMed

    Thapa, Bindu; Bahadur Kc, Remant; Uludağ, Hasan

    2018-02-01

    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in variety of cancer cells without affecting most normal cells, which makes it a promising agent for cancer therapy. However, TRAIL therapy is clinically not effective due to resistance induction. To identify novel regulators of TRAIL that can aid in therapy, protein targets whose silencing sensitized breast cancer cells against TRAIL were screened with an siRNA library against 446 human apoptosis-related proteins in MDA-231 cells. Using a cationic lipopolymer (PEI-αLA) for delivery of library members, 16 siRNAs were identified that sensitized the TRAIL-induced death in MDA-231 cells. The siRNAs targeting BCL2L12 and SOD1 were further evaluated based on the novelty and their ability to sensitize TRAIL induced cell death. Silencing both targets sensitized TRAIL-mediated cell death in MDA-231 cells as well as TRAIL resistant breast cancer cells, MCF-7. Combination of TRAIL and siRNA silencing BCL2L12 had no effect in normal human umbilical vein cells and human bone marrow stromal cell. The silencing of BCL2L12 and SOD1 enhanced TRAIL-mediated apoptosis in MDA-231 cells via synergistically activating capsase-3 activity. Hence, here we report siRNAs targeting BCL2L12 and SOD1 as a novel regulator of TRAIL-induced cell death in breast cancer cells, providing a new approach for enhancing TRAIL therapy for breast cancer. The combination of siRNA targeting BCL2L12 and TRAIL can be a highly effective synergistic pair in breast cancer cells with minimal effect on the non-transformed cells. © 2017 UICC.

  11. Citizens Advisory Committees.

    ERIC Educational Resources Information Center

    Stemnock, Suzanne K.

    1968-01-01

    This document contains the results of a national survey designed to determine the composition and location of permanent citizens advisory committees operating within the nation's school districts. The 52 district-wide, continuing citizens advisory bodies identified by 290 responding school systems are listed alphabetically by State. The following…

  12. Target distance-dependent variation of hearing sensitivity during echolocation in a false killer whale.

    PubMed

    Supin, Alexander Ya; Nachtigall, Paul E; Breese, Marlee

    2010-06-01

    Evidence of varying hearing sensitivity according to the target distance was obtained in a false killer whale Pseudorca crassidens during echolocation. Auditory evoked potentials (AEPs) triggered by echolocation clicks were recorded. The target distance varied from 1 to 6 m. The records contained AEPs to the self-heard emitted click and AEPs to the echoes. Mean level of echolocation clicks depended on distance (the longer the distance, the higher the click level), however, the effect of click level on AEP amplitude was eliminated by extracting AEPs to clicks of certain particular levels. The amplitude of the echo-provoked AEP was almost independent of distance, however, the amplitude of the AEP to the emitted click, did depend on distance within a range from 1 to 4 m: the longer the distance, the higher the amplitude. The latter result is interpreted as confirmational evidence that the animal is capable of varying hearing sensitivity according to target distance. The variation of hearing sensitivity may help to compensate for the echo attenuation with distance; as a secondary effect, this variation manifested itself in a variation of the amplitude of the AEP to emitted clicks.

  13. Advisory: Definitions, Descriptions, Decisions, Directions.

    ERIC Educational Resources Information Center

    Galassi, John P.; Gulledge, Suzanne A.; Cox, Nancy D.

    Advisory groups have played an essential role in improving the school climate and conditions for young adolescents in schools. How middle school decision makers go about the process of designing or re-designing an advisory program needs to be considered. A discussion is presented of the background information that helps define advisories. It…

  14. 75 FR 2880 - Homeland Security Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-19

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2009-0160] Homeland Security Advisory Council... advisory committee meeting. SUMMARY: The Homeland Security Advisory Council (HSAC) will meet on February 3.... Mail: Homeland Security Advisory Council, 1100 Hampton Park Boulevard, Mailstop 0850, Capitol Heights...

  15. Ultra-Sensitive Detection of Plasmodium falciparum by Amplification of Multi-Copy Subtelomeric Targets

    PubMed Central

    Hofmann, Natalie; Mwingira, Felista; Shekalaghe, Seif; Robinson, Leanne J.; Mueller, Ivo; Felger, Ingrid

    2015-01-01

    Background Planning and evaluating malaria control strategies relies on accurate definition of parasite prevalence in the population. A large proportion of asymptomatic parasite infections can only be identified by surveillance with molecular methods, yet these infections also contribute to onward transmission to mosquitoes. The sensitivity of molecular detection by PCR is limited by the abundance of the target sequence in a DNA sample; thus, detection becomes imperfect at low densities. We aimed to increase PCR diagnostic sensitivity by targeting multi-copy genomic sequences for reliable detection of low-density infections, and investigated the impact of these PCR assays on community prevalence data. Methods and Findings Two quantitative PCR (qPCR) assays were developed for ultra-sensitive detection of Plasmodium falciparum, targeting the high-copy telomere-associated repetitive element 2 (TARE-2, ∼250 copies/genome) and the var gene acidic terminal sequence (varATS, 59 copies/genome). Our assays reached a limit of detection of 0.03 to 0.15 parasites/μl blood and were 10× more sensitive than standard 18S rRNA qPCR. In a population cross-sectional study in Tanzania, 295/498 samples tested positive using ultra-sensitive assays. Light microscopy missed 169 infections (57%). 18S rRNA qPCR failed to identify 48 infections (16%), of which 40% carried gametocytes detected by pfs25 quantitative reverse-transcription PCR. To judge the suitability of the TARE-2 and varATS assays for high-throughput screens, their performance was tested on sample pools. Both ultra-sensitive assays correctly detected all pools containing one low-density P. falciparum–positive sample, which went undetected by 18S rRNA qPCR, among nine negatives. TARE-2 and varATS qPCRs improve estimates of prevalence rates, yet other infections might still remain undetected when absent in the limited blood volume sampled. Conclusions Measured malaria prevalence in communities is largely determined by the

  16. 77 FR 64335 - Notification of a Public Teleconference of the Science Advisory Board; Perchlorate Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-19

    ... Science Advisory Board; Perchlorate Advisory Panel AGENCY: Environmental Protection Agency (EPA). ACTION... announces two public teleconferences of the SAB Perchlorate Advisory Panel to discuss its revised draft... Epidemiological Evidence to Develop a Maximum Contaminant Level Goal (MCLG) for Perchlorate. DATES: The public...

  17. 77 FR 25706 - Notice of Advisory Committee Closed Meeting; U.S. Strategic Command Strategic Advisory Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-01

    ..., Command and Control, Science and Technology, Missile Defense. Meeting Accessibility: Pursuant to 5 U.S.C... DEPARTMENT OF DEFENSE Notice of Advisory Committee Closed Meeting; U.S. Strategic Command Strategic Advisory Group AGENCY: Department of Defense. ACTION: Notice of Advisory Committee closed meeting...

  18. 16 CFR 1018.12 - Statutory advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Statutory advisory committees. 1018.12 Section 1018.12 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ADVISORY COMMITTEE MANAGEMENT Establishment of Advisory Committees § 1018.12 Statutory advisory committees. The Commission has...

  19. Public Library Advisory Board Handbook.

    ERIC Educational Resources Information Center

    Bailey, Alvin R., Ed.; And Others

    In Texas, public library advisory boards are a recent innovation that have developed as a result of the Council-Manager form of government. This handbook is a response to that development as a compilation of information on the most efficient roles and functions of advisory boards. An advisory board is appointed by the governing body of which the…

  20. Dual signal amplification for highly sensitive electrochemical detection of uropathogens via enzyme-based catalytic target recycling.

    PubMed

    Su, Jiao; Zhang, Haijie; Jiang, Bingying; Zheng, Huzhi; Chai, Yaqin; Yuan, Ruo; Xiang, Yun

    2011-11-15

    We report an ultrasensitive electrochemical approach for the detection of uropathogen sequence-specific DNA target. The sensing strategy involves a dual signal amplification process, which combines the signal enhancement by the enzymatic target recycling technique with the sensitivity improvement by the quantum dot (QD) layer-by-layer (LBL) assembled labels. The enzyme-based catalytic target DNA recycling process results in the use of each target DNA sequence for multiple times and leads to direct amplification of the analytical signal. Moreover, the LBL assembled QD labels can further enhance the sensitivity of the sensing system. The coupling of these two effective signal amplification strategies thus leads to low femtomolar (5fM) detection of the target DNA sequences. The proposed strategy also shows excellent discrimination between the target DNA and the single-base mismatch sequences. The advantageous intrinsic sequence-independent property of exonuclease III over other sequence-dependent enzymes makes our new dual signal amplification system a general sensing platform for monitoring ultralow level of various types of target DNA sequences. Copyright © 2011 Elsevier B.V. All rights reserved.

  1. Highly sensitive and specific colorimetric detection of cancer cells via dual-aptamer target binding strategy.

    PubMed

    Wang, Kun; Fan, Daoqing; Liu, Yaqing; Wang, Erkang

    2015-11-15

    Simple, rapid, sensitive and specific detection of cancer cells is of great importance for early and accurate cancer diagnostics and therapy. By coupling nanotechnology and dual-aptamer target binding strategies, we developed a colorimetric assay for visually detecting cancer cells with high sensitivity and specificity. The nanotechnology including high catalytic activity of PtAuNP and magnetic separation & concentration plays a vital role on the signal amplification and improvement of detection sensitivity. The color change caused by small amount of target cancer cells (10 cells/mL) can be clearly distinguished by naked eyes. The dual-aptamer target binding strategy guarantees the detection specificity that large amount of non-cancer cells and different cancer cells (10(4) cells/mL) cannot cause obvious color change. A detection limit as low as 10 cells/mL with detection linear range from 10 to 10(5) cells/mL was reached according to the experimental detections in phosphate buffer solution as well as serum sample. The developed enzyme-free and cost effective colorimetric assay is simple and no need of instrument while still provides excellent sensitivity, specificity and repeatability, having potential application on point-of-care cancer diagnosis. Copyright © 2015 Elsevier B.V. All rights reserved.

  2. Mitochondrial DNA Targets Increase Sensitivity of Malaria Detection Using Loop-Mediated Isothermal Amplification ▿

    PubMed Central

    Polley, Spencer D.; Mori, Yasuyoshi; Watson, Julie; Perkins, Mark D.; González, Iveth J.; Notomi, Tsugunori; Chiodini, Peter L.; Sutherland, Colin J.

    2010-01-01

    Loop-mediated isothermal amplification (LAMP) of DNA offers the ability to detect very small quantities of pathogen DNA following minimal tissue sample processing and is thus an attractive methodology for point-of-care diagnostics. Previous attempts to diagnose malaria by the use of blood samples and LAMP have targeted the parasite small-subunit rRNA gene, with a resultant sensitivity for Plasmodium falciparum of around 100 parasites per μl. Here we describe the use of mitochondrial targets for LAMP-based detection of any Plasmodium genus parasite and of P. falciparum specifically. These new targets allow routine amplification from samples containing as few as five parasites per μl of blood. Amplification is complete within 30 to 40 min and is assessed by real-time turbidimetry, thereby offering rapid diagnosis with greater sensitivity than is achieved by the most skilled microscopist or antigen detection using lateral flow immunoassays. PMID:20554824

  3. 75 FR 33616 - Science Advisory Board Staff Office; Notification of Closed Meetings of the Science Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-14

    ... Closed Meetings of the Science Advisory Board's Scientific and Technological Achievement Awards Committee... Agency's (EPA), Science Advisory Board (SAB) Staff Office announces a meeting and teleconference of the....gov . The SAB Mailing address is: U.S. EPA Science Advisory Board (1400F), U.S. Environmental...

  4. 75 FR 4069 - Science Advisory Board Staff Office; Notification of a Clean Air Scientific Advisory Committee...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-26

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9106-8] Science Advisory Board Staff Office; Notification of.... SUMMARY: The Environmental Protection Agency (EPA or Agency) Science Advisory Board (SAB) Staff Office is... may contact Ms. Kyndall Barry, Designated Federal Officer (DFO), EPA Science Advisory Board (1400F), U...

  5. 75 FR 10479 - Science Advisory Board Staff Office; Notification of a Clean Air Scientific Advisory Committee...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-08

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9124-1] Science Advisory Board Staff Office; Notification of... Environmental Protection Agency (EPA) Science Advisory Board (SAB) Staff Office announces a public meeting of... may contact Ms. Kyndall Barry, Designated Federal Officer (DFO), EPA Science Advisory Board (1400F), U...

  6. NGR-modified pH-sensitive liposomes for controlled release and tumor target delivery of docetaxel.

    PubMed

    Gu, Zili; Chang, Minglu; Fan, Yang; Shi, Yanbin; Lin, Guimei

    2017-12-01

    As current tumor chemotherapy faces many challenges, it is important to develop drug delivery systems with increased tumor-targeting ability, enhanced therapeutic effects and reduced side effects. In this study, a pH-sensitive liposome was constructed containing CHEMS-anchored PEG2000 for extended circulation and NGR peptide as the targeting moiety. The NGR-modified docetaxel-loaded pH-sensitive extended-circulation liposomes (DTX/NGR-PLL) prepared possess suitable physiochemical properties, including particle size of approximately 200nm, drug encapsulation efficiency of approximately 70%, and pH-sensitive drug release properties. Experiments performed in vitro and in vivo on human fibrosarcoma cells (HT-1080) and human breast adenocarcinoma cells (MCF-7) verified the specific targeting ability and enhanced antitumor activity to HT-1080 cells. The results of intravenous administration demonstrated that NGR-modified liposomes can significantly and safely accumulate in tumor tissue in xenografted nude mice. In conclusion, the liposomes constructed hold promise as a safe and efficient drug delivery system for specific tumor treatment. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. 78 FR 50040 - Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ... COMMODITY FUTURES TRADING COMMISSION Technology Advisory Committee AGENCY: Commodity Futures Trading Commission. ACTION: Notice of Meeting of Technology Advisory Committee. SUMMARY: The Commodity Futures Trading Commission (CFTC) announces that on September 12, 2013, the CFTC's Technology Advisory...

  8. 76 FR 44912 - Science Advisory Board Staff Office; Notification of Closed Meetings of the Science Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-27

    ... Closed Meetings of the Science Advisory Board's Scientific and Technological Achievement Awards Committee... Agency's (EPA), Science Advisory Board (SAB) Staff Office announces a meeting and teleconference of the[email protected] . The SAB Mailing address is: U.S. EPA Science Advisory Board (1400R), U.S. Environmental...

  9. 78 FR 28207 - Electricity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-14

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee AGENCY: Office of Electricity Delivery and... a meeting of the Electricity Advisory Committee (EAC). The Federal Advisory Committee Act (Pub. L..., Arlington, Virginia 22203. FOR FURTHER INFORMATION CONTACT: Matthew Rosenbaum, Office of Electricity...

  10. 77 FR 15737 - Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-16

    ... COMMODITY FUTURES TRADING COMMISSION Technology Advisory Committee AGENCY: Commodity Futures Trading Commission (``CFTC''). ACTION: Notice of meeting of Technology Advisory Committee. SUMMARY: The CFTC announces that on March 29, 2012, the CFTC's Technology Advisory Committee (``TAC'') will hold a...

  11. 77 FR 29995 - Electricity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee AGENCY: Office of Electricity Delivery and... a meeting of the Electricity Advisory Committee (EAC). The Federal Advisory Committee Act (Pub. L... INFORMATION CONTACT: Matthew Rosenbaum, Office of Electricity Delivery and Energy Reliability, U.S. Department...

  12. 77 FR 58534 - Electricity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-21

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee AGENCY: Office of Electricity Delivery and... a meeting of the Electricity Advisory Committee (EAC). The Federal Advisory Committee Act (Pub. L... FURTHER INFORMATION CONTACT: Matthew Rosenbaum, Office of Electricity Delivery and Energy Reliability, U.S...

  13. 76 FR 59667 - Electricity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-27

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee AGENCY: Office of Electricity Delivery and... a meeting of the Electricity Advisory Committee (EAC). The Federal Advisory Committee Act (Pub. L..., Virginia 22203. FOR FURTHER INFORMATION CONTACT: David Meyer, Office of Electricity Delivery and Energy...

  14. 75 FR 61454 - Electricity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-05

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee AGENCY: Department of Energy, Office of Electricity Delivery and Energy Reliability. ACTION: Notice of open meeting. SUMMARY: This notice announces the open meeting of the re-established DOE Electricity Advisory Committee. The Federal Advisory...

  15. 76 FR 57023 - Science Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration (NOAA) Science Advisory... forth the schedule and proposed agenda of a forthcoming meeting of the NOAA Science Advisory Board. The... date. SUPPLEMENTARY INFORMATION: The Science Advisory Board (SAB) was established by a Decision...

  16. 75 FR 54854 - Science Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-09

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration Science Advisory Board... the schedule and proposed agenda of a forthcoming meeting of the NOAA Science Advisory Board. The... FURTHER INFORMATION CONTACT: Dr. Cynthia Decker, Executive Director, Science Advisory Board, NOAA, Rm...

  17. 76 FR 64088 - World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP STAC or Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-17

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention [Docket Number NIOSH-248] World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP STAC or Advisory Committee), National Institute for Occupational Safety and Health (NIOSH) In accordance with section 10(a)(2) of the Federal Advisory...

  18. Characterization of mechano-sensitive nano-containers for targeted vasodilation

    NASA Astrophysics Data System (ADS)

    Buscema, Marzia; Deyhle, Hans; Pfohl, Thomas; Hieber, Simone E.; Zumbuehl, Andreas; Müller, Bert

    2016-04-01

    Cardiovascular diseases are the worldwide number one cause of mortality. The blood flow in diseased human coronary arteries differs from the blood flow in the healthy vessels. This fact should be used for designing targeted localized delivery of vasodilators with a purely physical drug release trigger. Thus, we have proposed mechano-sensitive liposomes as mechano-sensitive containers. One has to tailor the liposome's properties, so that containers are stable under physiological conditions in health, but release their cargo near the constricted vessels at body temperature. In order to determine the shear stress threshold for release, both the morphology of the healthy and diseased human arteries and the mechanical property of the liposomes have to be known. We have shown that micro computed tomography (μCT) techniques allow visualizing the lumen of human coronary arteries and provide the basis for flow simulations to extract the wall shear stress of healthy and stenosed regions in human coronary arteries. The behavior of the mechano-sensitive liposomes is currently investigated by means of microfluidics and spatially resolved small-angle X-ray scattering. The liposomes are injected into micro-channels mimicking in vivo situation. The scattering signal from the liposomes reveals information about their size, shape, and wall thickness.

  19. 50 CFR 100.12 - Local advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Local advisory committees. 100.12 Section... Structure § 100.12 Local advisory committees. (a) The Board shall establish such local Federal Advisory... in § 100.11. (b) Local Federal Advisory Committees, if established by the Board, shall operate in...

  20. 50 CFR 100.12 - Local advisory committees.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 8 2011-10-01 2011-10-01 false Local advisory committees. 100.12 Section... Structure § 100.12 Local advisory committees. (a) The Board shall establish such local Federal Advisory... in § 100.11. (b) Local Federal Advisory Committees, if established by the Board, shall operate in...

  1. 76 FR 37103 - Electricity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-24

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee AGENCY: Office of Electricity Delivery and... a meeting of the Electricity Advisory Committee (EAC). The Federal Advisory Committee Act (Pub. L...: David Meyer, Office of Electricity Delivery and Energy Reliability, U.S. Department of Energy, Forrestal...

  2. 77 FR 476 - Science Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-05

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration (NOAA) Science Advisory... forth the schedule and proposed agenda of a forthcoming meeting of the NOAA Science Advisory Board. The... INFORMATION: The Science Advisory Board (SAB) was established by a Decision Memorandum dated September 25...

  3. 77 FR 14017 - World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP STAC or Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-08

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP STAC or Advisory Committee), National Institute for Occupational Safety and Health (NIOSH) In accordance with section 10(a)(2) of the Federal Advisory Committee Act (Pub. L. 92-463),...

  4. 77 FR 4820 - World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP STAC or Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-31

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP STAC or Advisory Committee), National Institute for Occupational Safety and Health (NIOSH) In accordance with section 10(a)(2) of the Federal Advisory Committee Act (Pub. L. 92-463),...

  5. 76 FR 81947 - World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP STAC or Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-29

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP STAC or Advisory Committee), National Institute for Occupational Safety and Health (NIOSH) In accordance with section 10(a)(2) of the Federal Advisory Committee Act (Pub. L. 92-463)...

  6. 75 FR 11883 - Science Advisory Board Staff Office; Notification of a Public Meeting of the Science Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9126-2] Science Advisory Board Staff Office; Notification of a Public Meeting of the Science Advisory Board (SAB) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: The Environmental Protection Agency (EPA) Science Advisory Board (SAB) Staff...

  7. 75 FR 6358 - Federal Advisory Committee; Defense Advisory Board for Employer Support of the Guard and Reserve...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Defense Advisory Board...; Charter Revision AGENCY: Department of Defense (DoD). ACTION: Federal advisory committee charter. SUMMARY... Committee Reports to include the Under Secretary of Defense (Personnel and Readiness). FOR FURTHER...

  8. 77 FR 52335 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-29

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety.... Background: The Advisory Board was established under the Energy Employees Occupational Illness Compensation...

  9. 77 FR 9254 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-16

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety.... Background: The Advisory Board was established under the Energy Employees Occupational Illness Compensation...

  10. 77 FR 69486 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-19

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... people. Background: The Advisory Board was established under the Energy Employees Occupational Illness...

  11. 76 FR 5814 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-02

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety...: The Advisory Board was established under the Energy Employees Occupational Illness Compensation...

  12. 75 FR 66769 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-29

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety...: The Advisory Board was established under the Energy Employees Occupational Illness Compensation...

  13. 75 FR 13212 - Advisory Committee on Women Veterans; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-18

    ...) that a meeting of the Advisory Committee on Women Veterans will be held on March 30-April 1, 2010, at... Administration initiatives targeting women Veterans. On March 31, the Committee will meet in the South American AB Room and the session will include an update on VA's outreach to women Veterans, VA's contract exam...

  14. 13 CFR 130.360 - SBDC advisory boards.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... the operation of the SBDC network. (2) The advisory board shall be referred to as a State SBDC... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false SBDC advisory boards. 130.360... CENTERS § 130.360 SBDC advisory boards. (a) State/Regional Advisory Boards. (1) The Lead Center must...

  15. 13 CFR 130.360 - SBDC advisory boards.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... the operation of the SBDC network. (2) The advisory board shall be referred to as a State SBDC... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false SBDC advisory boards. 130.360... CENTERS § 130.360 SBDC advisory boards. (a) State/Regional Advisory Boards. (1) The Lead Center must...

  16. 13 CFR 130.360 - SBDC advisory boards.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... the operation of the SBDC network. (2) The advisory board shall be referred to as a State SBDC... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false SBDC advisory boards. 130.360... CENTERS § 130.360 SBDC advisory boards. (a) State/Regional Advisory Boards. (1) The Lead Center must...

  17. 13 CFR 130.360 - SBDC advisory boards.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... the operation of the SBDC network. (2) The advisory board shall be referred to as a State SBDC... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false SBDC advisory boards. 130.360... CENTERS § 130.360 SBDC advisory boards. (a) State/Regional Advisory Boards. (1) The Lead Center must...

  18. 13 CFR 130.360 - SBDC advisory boards.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... the operation of the SBDC network. (2) The advisory board shall be referred to as a State SBDC... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false SBDC advisory boards. 130.360... CENTERS § 130.360 SBDC advisory boards. (a) State/Regional Advisory Boards. (1) The Lead Center must...

  19. 78 FR 55692 - Electricity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-11

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee AGENCY: Office of Electricity Delivery and... a meeting of the Electricity Advisory Committee (EAC). The Federal Advisory Committee Act (Pub. L... Electricity Delivery and Energy Reliability, U.S. Department of Energy, Forrestal Building, Room 8G-017, 1000...

  20. 5 CFR 724.403 - Advisory guidelines.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Advisory guidelines. 724.403 Section 724.403 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS... RETALIATION ACT OF 2002 Best Practices § 724.403 Advisory guidelines. OPM will issue advisory guidelines to...

  1. 77 FR 58356 - Science Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-20

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration Science Advisory Board... the schedule and proposed agenda of a forthcoming meeting of the NOAA Science Advisory Board. The... Science Advisory Board (SAB) was established by a Decision Memorandum dated September 25, 1997, and is the...

  2. 76 FR 8715 - Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-15

    ... COMMODITY FUTURES TRADING COMMISSION Technology Advisory Committee AGENCY: Commodity Futures Trading Commission (``CFTC''). ACTION: Notice of meeting of Technology Advisory Committee. SUMMARY: The Technology Advisory Committee will hold a rescheduled public meeting on March 1, 2011, from 1 p.m. to 5 p.m...

  3. 76 FR 75874 - Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-05

    ... COMMODITY FUTURES TRADING COMMISSION Technology Advisory Committee AGENCY: Commodity Futures Trading Commission (``CFTC''). ACTION: Notice of Meeting of Technology Advisory Committee. SUMMARY: The Technology Advisory Committee will hold a public meeting on December 13, 2011, from 10 a.m. to 5 p.m., at the...

  4. 76 FR 776 - Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-06

    ... COMMODITY FUTURES TRADING COMMISSION Technology Advisory Committee AGENCY: Commodity Futures Trading Commission (``CFTC''). ACTION: Notice of meeting of Technology Advisory Committee. SUMMARY: The Technology Advisory Committee will hold a public meeting on January 27, 2011, from 1 p.m. to 5 p.m., at the...

  5. 77 FR 43090 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-23

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... Advisory Board was established under the Energy Employees Occupational Illness Compensation Program Act of...

  6. 75 FR 35496 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-22

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... Advisory Board was established under the Energy Employees Occupational Illness Compensation Program Act of...

  7. 77 FR 32117 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-31

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... Advisory Board was established under the Energy Employees Occupational Illness Compensation Program Act of...

  8. 76 FR 47590 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-05

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... Advisory Board was established under the Energy Employees Occupational Illness Compensation Program Act of...

  9. 75 FR 22560 - Federal Advisory Committee; Naval Research Advisory Committee; Charter Renewal

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-29

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Naval Research Advisory... 102-3.50, the Department of Defense gives notice that it is renewing the charter for the Naval... independent advice and recommendations to the Secretary of the Navy, the Chief of Naval Operations and the...

  10. 5 CFR 724.403 - Advisory guidelines.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Advisory guidelines. 724.403 Section 724... (CONTINUED) IMPLEMENTATION OF TITLE II OF THE NOTIFICATION AND FEDERAL EMPLOYEE ANTIDISCRIMINATION AND RETALIATION ACT OF 2002 Best Practices § 724.403 Advisory guidelines. OPM will issue advisory guidelines to...

  11. 5 CFR 724.403 - Advisory guidelines.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 2 2013-01-01 2013-01-01 false Advisory guidelines. 724.403 Section 724... (CONTINUED) IMPLEMENTATION OF TITLE II OF THE NOTIFICATION AND FEDERAL EMPLOYEE ANTIDISCRIMINATION AND RETALIATION ACT OF 2002 Best Practices § 724.403 Advisory guidelines. OPM will issue advisory guidelines to...

  12. 5 CFR 724.403 - Advisory guidelines.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 2 2014-01-01 2014-01-01 false Advisory guidelines. 724.403 Section 724... (CONTINUED) IMPLEMENTATION OF TITLE II OF THE NOTIFICATION AND FEDERAL EMPLOYEE ANTIDISCRIMINATION AND RETALIATION ACT OF 2002 Best Practices § 724.403 Advisory guidelines. OPM will issue advisory guidelines to...

  13. 5 CFR 724.403 - Advisory guidelines.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 2 2012-01-01 2012-01-01 false Advisory guidelines. 724.403 Section 724... (CONTINUED) IMPLEMENTATION OF TITLE II OF THE NOTIFICATION AND FEDERAL EMPLOYEE ANTIDISCRIMINATION AND RETALIATION ACT OF 2002 Best Practices § 724.403 Advisory guidelines. OPM will issue advisory guidelines to...

  14. 75 FR 2542 - Science Advisory Board Staff Office Notification of a Public Meeting of the Science Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-15

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9104-2] Science Advisory Board Staff Office Notification of a Public Meeting of the Science Advisory Board Committee on Science Integration for Decisionmaking AGENCY... Agency) Science Advisory Board (SAB) Staff Office announces a public meeting of the SAB Committee on...

  15. 75 FR 9895 - Science Advisory Board Staff Office; Notification of a Public Meeting of the Science Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9122-2] Science Advisory Board Staff Office; Notification of a Public Meeting of the Science Advisory Board; Committee on Science Integration for Decision Making... Agency (EPA or Agency) Science Advisory Board (SAB) Staff Office announces a public meeting of the SAB...

  16. 76 FR 53671 - Federal Advisory Committee; Defense Intelligence Agency Advisory Board; Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-29

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Defense Intelligence Agency Advisory Board; Closed Meeting AGENCY: Defense Intelligence Agency (DIA), Department of Defense... amended), and 41 CFR 102-3.150 the Department of Defense announces that Defense Intelligence Agency...

  17. 75 FR 57743 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-22

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Department of... of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act... INFORMATION: Purpose of the Committee: The purpose of the Unconventional Resources Technology Advisory...

  18. 78 FR 68430 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-14

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Office of... meeting of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act... the Unconventional Resources Technology Advisory Committee is to provide advice on development and...

  19. 78 FR 58294 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-23

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Office of... meeting of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act... the Unconventional Resources Technology Advisory Committee is to provide advice on development and...

  20. 77 FR 59182 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-26

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Office of... meeting of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act... INFORMATION: Purpose of the Committee: The purpose of the Unconventional Resources Technology Advisory...

  1. 76 FR 77990 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-15

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Office of... meeting of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act... INFORMATION: Purpose of the Committee: The purpose of the Unconventional Resources Technology Advisory...

  2. 78 FR 17924 - U.S. Strategic Command Strategic Advisory Group; Notice of Federal Advisory Committee Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-25

    ... DEPARTMENT OF DEFENSE Office of the Secretary U.S. Strategic Command Strategic Advisory Group... following federal advisory committee: U.S. Strategic Command Strategic Advisory Group. DATES: April 18, 2013..., intelligence, and policy-related issues to the Commander, U.S. Strategic Command, during the development of the...

  3. 76 FR 71567 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-18

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety and Health (NIOSH) In accordance with section 10(a)(2) of the Federal Advisory Committee Act (Pub. L...

  4. 78 FR 69682 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-20

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention (CDC) Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety and Health (NIOSH) In accordance with section 10(a)(2) of the Federal Advisory Committee Act (Pub...

  5. 76 FR 26301 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-06

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety and Health (NIOSH) In accordance with section 10(a)(2) of the Federal Advisory Committee Act (Pub. L...

  6. 78 FR 70932 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Office of... meeting of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act... of the Unconventional Resources Technology Advisory Committee is to provide advice on development and...

  7. 75 FR 57743 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-22

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Department of... of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act...: Purpose of the Committee: The purpose of the Unconventional Resources Technology Advisory Committee is to...

  8. 78 FR 53741 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-30

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Office of... meeting of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act... of the Unconventional Resources Technology Advisory Committee is to provide advice on development and...

  9. 75 FR 36346 - Olympic National Forest; Title II Resource Advisory Committee Meeting Advisory

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-25

    ... DEPARTMENT OF AGRICULTURE Olympic National Forest; Title II Resource Advisory Committee Meeting Advisory AGENCY: Olympic National Forest, USDA Forest Service. ACTION: Notice of meeting. SUMMARY: The... this meeting will be to review project proposals and provide recommendations for Title II projects to...

  10. 77 FR 2133 - Debt Management Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-13

    ... DEPARTMENT OF THE TREASURY Debt Management Advisory Committee Meeting Notice is hereby given... management advisory committee: Treasury Borrowing Advisory Committee of the Securities Industry and Financial... financing operations. Historically, this advice has been offered by debt management advisory committees...

  11. 78 FR 22034 - Debt Management Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-12

    ... DEPARTMENT OF THE TREASURY Debt Management Advisory Committee Meeting Notice is hereby given... management advisory committee: Treasury Borrowing Advisory Committee of The Securities Industry and Financial... financing operations. Historically, this advice has been offered by debt management advisory committees...

  12. 78 FR 62941 - Debt Management Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ... DEPARTMENT OF THE TREASURY Debt Management Advisory Committee Meeting Notice is hereby given... management advisory committee: Treasury Borrowing Advisory Committee of The Securities Industry and Financial... financing operations. Historically, this advice has been offered by debt management advisory committees...

  13. 77 FR 5246 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-02

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Office of... meeting of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act... Committee: The purpose of the Unconventional Resources Technology Advisory Committee is to provide advice on...

  14. 77 FR 63300 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-16

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Office of... meeting of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act... Committee: The purpose of the Unconventional Resources Technology Advisory Committee is to provide advice on...

  15. 76 FR 64992 - Debt Management Advisory Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-19

    ... DEPARTMENT OF THE TREASURY Debt Management Advisory Committee; Meeting Notice is hereby given... management advisory committee: Treasury Borrowing Advisory Committee of the Securities Industry and Financial... operations. Historically, this advice has been offered by debt management advisory committees established by...

  16. 28 CFR 0.129 - Professional Responsibility Advisory Office.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Professional Responsibility Advisory... OF JUSTICE 2-Professional Responsibility Advisory Office § 0.129 Professional Responsibility Advisory Office. (a) The Professional Responsibility Advisory Office is headed by a Director appointed by the...

  17. 77 FR 47593 - Shoshone Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-09

    ... DEPARTMENT OF AGRICULTURE Forest Service Shoshone Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Shoshone Resource Advisory Committee (Committee... CONTACT: Olga Troxel, Resource Advisory Committee Coordinator, Shoshone National Forest Supervisor's...

  18. ITS Standards Advisory : Dynamic Message Signs (DMS)

    DOT National Transportation Integrated Search

    2003-01-01

    ITS Standards Advisories provide the transportation community with information and guidance on key activities related to ITS standards, with each Advisory focusing on a single ITS application and its corresponding standards. This advisory focuses on ...

  19. 16 CFR 16.13 - Renewal of advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Renewal of advisory committees. 16.13 Section 16.13 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.13 Renewal of advisory committees. (a) Any advisory committee...

  20. 16 CFR 16.12 - Termination of advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Termination of advisory committees. 16.12 Section 16.12 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.12 Termination of advisory committees. Any advisory committee shall...

  1. 16 CFR 1018.13 - Non-statutory advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Non-statutory advisory committees. 1018.13 Section 1018.13 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ADVISORY COMMITTEE MANAGEMENT Establishment of Advisory Committees § 1018.13 Non-statutory advisory committees. (a) In proposing...

  2. 49 CFR 95.7 - Industry advisory committees: Membership.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Industry advisory committees: Membership. 95.7 Section 95.7 Transportation Office of the Secretary of Transportation ADVISORY COMMITTEES § 95.7 Industry advisory committees: Membership. Each industry advisory committee must be reasonably representative of the...

  3. 49 CFR 95.7 - Industry advisory committees: Membership.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Industry advisory committees: Membership. 95.7 Section 95.7 Transportation Office of the Secretary of Transportation ADVISORY COMMITTEES § 95.7 Industry advisory committees: Membership. Each industry advisory committee must be reasonably representative of the...

  4. 49 CFR 95.7 - Industry advisory committees: Membership.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Industry advisory committees: Membership. 95.7 Section 95.7 Transportation Office of the Secretary of Transportation ADVISORY COMMITTEES § 95.7 Industry advisory committees: Membership. Each industry advisory committee must be reasonably representative of the...

  5. 75 FR 17701 - High Energy Physics Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-07

    ... DEPARTMENT OF ENERGY High Energy Physics Advisory Panel AGENCY: Department of Energy, Office of... Physics Advisory Panel (HEPAP). Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires... Energy Physics Advisory Panel; U.S. Department of Energy; SC-25/ Germantown Building, 1000 Independence...

  6. 22 CFR 214.32 - Calling of advisory committee meetings.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Calling of advisory committee meetings. 214.32 Section 214.32 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ADVISORY COMMITTEE MANAGEMENT Operation of Advisory Committees § 214.32 Calling of advisory committee meetings. (a) No advisory committee...

  7. 76 FR 41196 - Shoshone Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-13

    ... DEPARTMENT OF AGRICULTURE Forest Service Shoshone Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Shoshone Resource Advisory Committee (Committee... INFORMATION CONTACT: Olga Troxel, Resource Advisory Committee Coordinator, Shoshone National Forest Supervisor...

  8. 76 FR 12317 - Shoshone Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-07

    ... DEPARTMENT OF AGRICULTURE Forest Service Shoshone Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Shoshone Resource Advisory Committee (Committee..., Resource Advisory Committee Coordinator, Shoshone National Forest Supervisor's Office, (307) 578-5164...

  9. 75 FR 38086 - Technology Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-01

    ... COMMODITY FUTURES TRADING COMMISSION Technology Advisory Committee Meeting The Commodity Futures Trading Commission's (``Commission'') Technology Advisory Committee will conduct a meeting on Wednesday... Technology Advisory Committee, which will inform the Commission of technological issues and developments...

  10. 77 FR 18786 - Eastern Washington Cascades Provincial Advisory Committee and the Yakima Provincial Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ... DEPARTMENT OF AGRICULTURE Forest Service Eastern Washington Cascades Provincial Advisory Committee and the Yakima Provincial Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting... Chief's 10-Year Stewardship Challenge, Upper Yakima Basin Water Enhancement Project, Holden Mine...

  11. 49 CFR 95.11 - Meetings; industry advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Meetings; industry advisory committees. 95.11... Meetings; industry advisory committees. (a) Meetings of an industry advisory committee may be held only at...) No industry advisory committee may receive, compile, or discuss data or reports showing the current...

  12. 49 CFR 95.11 - Meetings; industry advisory committees.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Meetings; industry advisory committees. 95.11... Meetings; industry advisory committees. (a) Meetings of an industry advisory committee may be held only at...) No industry advisory committee may receive, compile, or discuss data or reports showing the current...

  13. 49 CFR 95.11 - Meetings; industry advisory committees.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Meetings; industry advisory committees. 95.11... Meetings; industry advisory committees. (a) Meetings of an industry advisory committee may be held only at...) No industry advisory committee may receive, compile, or discuss data or reports showing the current...

  14. 77 FR 56607 - Shoshone Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-13

    ... DEPARTMENT OF AGRICULTURE Forest Service Shoshone Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Shoshone Resource Advisory Committee (Committee) is... call. FOR FURTHER INFORMATION CONTACT: Olga Troxel, Resource Advisory Committee Coordinator, Shoshone...

  15. 75 FR 9416 - Advisory Committee Information Hotline

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-02

    ... Drugs Advisory Committee 3014512542 Peripheral and Central Nervous System Drugs Advisory Committee... Devices Panel 3014512624 Circulatory System Devices Panel 3014512625 Clinical Chemistry and Clinical... about any particular advisory committee meeting, this system will provide interested parties with timely...

  16. 77 FR 43064 - Meeting; Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-23

    ... COMMODITY FUTURES TRADING COMMISSION Meeting; Technology Advisory Committee AGENCY: Commodity Futures Trading Commission (CFTC). ACTION: Notice of emergency meeting of technology advisory committee. SUMMARY: The CFTC announces that on Thursday, July 26, 2012, the CFTC's Technology Advisory Committee...

  17. 22 CFR 214.2 - Definition of advisory committee.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Definition of advisory committee. 214.2 Section 214.2 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ADVISORY COMMITTEE MANAGEMENT General § 214.2 Definition of advisory committee. (a) The term advisory committee is defined in section 3(2) of...

  18. 10 CFR 7.4 - Establishment of advisory committees.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Establishment of advisory committees. 7.4 Section 7.4 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.4 Establishment of advisory committees. (a) An NRC advisory committee may be established under this part only if its establishment— (1) Is...

  19. 10 CFR 7.4 - Establishment of advisory committees.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Establishment of advisory committees. 7.4 Section 7.4 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.4 Establishment of advisory committees. (a) An NRC advisory committee may be established under this part only if its establishment— (1) Is...

  20. 10 CFR 7.4 - Establishment of advisory committees.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Establishment of advisory committees. 7.4 Section 7.4 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.4 Establishment of advisory committees. (a) An NRC advisory committee may be established under this part only if its establishment— (1) Is...

  1. 10 CFR 7.4 - Establishment of advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Establishment of advisory committees. 7.4 Section 7.4 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.4 Establishment of advisory committees. (a) An NRC advisory committee may be established under this part only if its establishment— (1) Is...

  2. 10 CFR 7.4 - Establishment of advisory committees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Establishment of advisory committees. 7.4 Section 7.4 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.4 Establishment of advisory committees. (a) An NRC advisory committee may be established under this part only if its establishment— (1) Is...

  3. 76 FR 3081 - Shoshone Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-19

    ... DEPARTMENT OF AGRICULTURE Forest Service Shoshone Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Shoshone Resource Advisory Committee (Committee... meeting will be held via conference call. FOR FURTHER INFORMATION CONTACT: Olga Troxel, Resource Advisory...

  4. 78 FR 64910 - Virginia Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-30

    ... DEPARTMENT OF AGRICULTURE Forest Service Virginia Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meetings. SUMMARY: The Virginia Resource Advisory Committee will meet in... Resource Advisory Committee meetings are subject to change or cancellation. Contact Michael Williams...

  5. 75 FR 46902 - Ketchikan Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-04

    ... DEPARTMENT OF AGRICULTURE Forest Service Ketchikan Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Ketchikan Resource Advisory Committee will meet in..., 3031 Tongass Avenue, Ketchikan, Alaska. Send written comments to Ketchikan Resource Advisory Committee...

  6. 77 FR 47592 - Ketchikan Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-09

    ... DEPARTMENT OF AGRICULTURE Forest Service Ketchikan Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Ketchikan Resource Advisory Committee will meet in... District, 3031 Tongass Avenue, Ketchikan, Alaska. Send written comments to Ketchikan Resource Advisory...

  7. 77 FR 51512 - Allegheny Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-24

    ... DEPARTMENT OF AGRICULTURE Forest Service Allegheny Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Allegheny Resource Advisory Committee will meet in...: The following business will be conducted: Allegheny Resource Advisory Committee members will solicit...

  8. 76 FR 23537 - Resource Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-27

    ... DEPARTMENT OF AGRICULTURE Resource Advisory Committee Meeting AGENCY: Forest Service, USDA. ACTION: Notice of Public Meeting, Sabine National Forest Resource Advisory Committee. SUMMARY: In accordance with.... Department of Agriculture, Forest Service, Sabine National Forest Resource Advisory Committee (RAC) meeting...

  9. 77 FR 18797 - Federal Advisory Committee; Defense Intelligence Agency (DIA) Advisory Board; Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Defense Intelligence... meeting necessarily includes discussions of classified information relating to DIA's intelligence... capabilities in support of current intelligence operations. Agenda May 2, 2012 S 8:30 a.m Convene Advisory...

  10. 76 FR 70425 - Federal Advisory Committee; Defense Intelligence Agency (DIA) Advisory Board; Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Defense Intelligence.... The meetings necessarily include discussions of classified information relating to DIA's intelligence... current intelligence operations. Agenda December 2, 2011 8:30 a.m Convene Advisory Mr. William Caniano...

  11. 77 FR 2277 - Federal Advisory Committee; Defense Intelligence Agency (DIA) Advisory Board; Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-17

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Defense Intelligence.... The meetings necessarily include discussions of classified information relating to DIA's intelligence... intelligence operations. Agenda February 24, 2012 8:30 a.m Convene Advisory Mr. William Caniano, Board Meeting...

  12. Beach Advisory and Closing Online Notification (BEACON) system

    EPA Pesticide Factsheets

    Beach Advisory and Closing Online Notification system (BEACON) is a colletion of state and local data reported to EPA about beach closings and advisories. BEACON is the public-facing query of the Program tracking, Beach Advisories, Water quality standards, and Nutrients database (PRAWN) which tracks beach closing and advisory information.

  13. Highly sensitive detection of target molecules using a new fluorescence-based bead assay

    NASA Astrophysics Data System (ADS)

    Scheffler, Silvia; Strauß, Denis; Sauer, Markus

    2007-07-01

    Development of immunoassays with improved sensitivity, specificity and reliability are of major interest in modern bioanalytical research. We describe the development of a new immunomagnetic fluorescence detection (IM-FD) assay based on specific antigen/antibody interactions and on accumulation of the fluorescence signal on superparamagnetic PE beads in combination with the use of extrinsic fluorescent labels. IM-FD can be easily modified by varying the order of coatings and assay conditions. Depending on the target molecule, antibodies (ABs), entire proteins, or small protein epitopes can be used as capture molecules. The presence of target molecules is detected by fluorescence microscopy using fluorescently labeled secondary or detection antibodies. Here, we demonstrate the potential of the new assay detecting the two tumor markers IGF-I and p53 antibodies in the clinically relevant concentration range. Our data show that the fluorescence-based bead assay exhibits a large dynamic range and a high sensitivity down to the subpicomolar level.

  14. 77 FR 16894 - Financial Research Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-22

    ... DEPARTMENT OF THE TREASURY Financial Research Advisory Committee AGENCY: Office of Financial Research, Treasury. ACTION: Notice of establishment of the Financial Research Advisory Committee and... is in the public interest to establish the Financial Research Advisory Committee. A Charter for the...

  15. 77 FR 10486 - Electricity Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-22

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee Meeting AGENCY: Office of Electricity Delivery... announces a meeting of the Electricity Advisory Committee (EAC). The Federal Advisory Committee Act (Pub. L... 20229. FOR FURTHER INFORMATION CONTACT: Matthew Rosenbaum, Office of Electricity Delivery and Energy...

  16. 78 FR 9038 - Electricity Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-07

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee Meeting AGENCY: Office of Electricity Delivery... announces a meeting of the Electricity Advisory Committee (EAC). The Federal Advisory Committee Act (Pub. L..., Arlington, Virginia 22203. FOR FURTHER INFORMATION CONTACT: Matthew Rosenbaum, Office of Electricity...

  17. 76 FR 10577 - Electricity Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-25

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee Meeting AGENCY: Office of Electricity Delivery... announces a meeting of the reestablished Electricity Advisory Committee (EAC). The Federal Advisory... CONTACT: David Meyer, Office of Electricity Delivery and Energy Reliability, U.S. Department of Energy...

  18. 75 FR 33241 - Coconino Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-11

    ... DEPARTMENT OF AGRICULTURE Forest Service Coconino Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Coconino Resource Advisory Committee will meet in... 86341. Send written comments to Brady Smith, RAC Coordinator, Coconino Resource Advisory Committee, c/o...

  19. 75 FR 39656 - Coconino Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-12

    ... DEPARTMENT OF AGRICULTURE Forest Service Coconino Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Coconino Resource Advisory Committee will meet in... Brady Smith, RAC Coordinator, Coconino Resource Advisory Committee, c/o Forest Service, USDA, 1824 S...

  20. 77 FR 50675 - Virginia Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-22

    ... DEPARTMENT OF AGRICULTURE Forest Service Virginia Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Virginia Resource Advisory Committee will meet in... Contact. All reasonable accommodation requests are managed on a case by case basis. Resource Advisory...

  1. 75 FR 52304 - Coconino Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-25

    ... DEPARTMENT OF AGRICULTURE Forest Service Coconino Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Coconino Resource Advisory Committee will meet in... Brady Smith. RAC Coordinator, Coconino Resource Advisory Committee, do Forest Service. USDA, 1824 5...

  2. 75 FR 6056 - National Geospatial Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-05

    ... DEPARTMENT OF THE INTERIOR Office of the Secretary National Geospatial Advisory Committee AGENCY: Office of the Secretary, Interior. ACTION: Notice of renewal of National Geospatial Advisory Committee... renewed the National Geospatial Advisory Committee. The Committee will provide advice and recommendations...

  3. 75 FR 53707 - Homeland Security Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-01

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2010-0074] Homeland Security Advisory Council... Meeting. SUMMARY: The Homeland Security Advisory Council (HSAC) will meet via teleconference for the... message. Fax: (202) 282-9207. Mail: Homeland Security Advisory Council, Department of Homeland Security...

  4. 76 FR 55079 - Homeland Security Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-06

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2011-0063] Homeland Security Advisory Council... Meeting. SUMMARY: The Homeland Security Advisory Council (HSAC) will meet via teleconference for the...) 282-9207. Mail: Homeland Security Advisory Council, Department of Homeland Security, Mailstop 0445...

  5. 75 FR 26782 - Homeland Security Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2010-0039] Homeland Security Advisory Council... Meeting. SUMMARY: The Homeland Security Advisory Council (HSAC) will meet via teleconference for the purpose of reviewing the final report of the HSAC's Quadrennial (Homeland Security) Review Advisory...

  6. 76 FR 58813 - Homeland Security Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-22

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2011-0096] Homeland Security Advisory Council... meeting. SUMMARY: The Homeland Security Advisory Council (HSAC) will meet via teleconference for the...-9207 Mail: Homeland Security Advisory Council, Department of Homeland Security, Mailstop 0445, 245...

  7. 77 FR 64532 - Homeland Security Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2012-0064] Homeland Security Advisory Council... meeting. SUMMARY: The Homeland Security Advisory Council (HSAC) will meet via teleconference for the...-9207 Mail: Homeland Security Advisory Council, Department of Homeland Security, Mailstop 0445, 245...

  8. 76 FR 21877 - Environmental Management Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-19

    ... DEPARTMENT OF ENERGY Environmental Management Advisory Board AGENCY: Department of Energy. ACTION: Notice of call for nominations for appointment to the Environmental Management Advisory Board. SUMMARY... Environmental Management Advisory Board. DATES: Nominations will be accepted through May 13, 2011. ADDRESSES...

  9. 75 FR 7440 - Eastern Washington Cascades Provincial Advisory Committee and the Yakima Provincial Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-19

    ... DEPARTMENT OF AGRICULTURE Forest Service Eastern Washington Cascades Provincial Advisory Committee and the Yakima Provincial Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting... Committee will meet on March 9, 2010 at the Sunnyslope Fire Station, 206 Easy Street, Wenatchee, WA. During...

  10. 75 FR 61693 - Coconino Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-06

    ... DEPARTMENT OF AGRICULTURE Forest Service Coconino Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Coconino Resource Advisory Committee will meet in Flagstaff, Arizona. The purpose of the meeting is to receive training on Resource Advisory Committees and...

  11. 76 FR 3081 - Sitka Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-19

    ... DEPARTMENT OF AGRICULTURE Forest Service Sitka Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Sitka Resource Advisory Committee will meet in Sitka...., Sitka, Alaska. Send written comments to Sitka Resource Advisory Committee, c/o District Ranger, USDA...

  12. 77 FR 54876 - Colville Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-06

    ... DEPARTMENT OF AGRICULTURE Forest Service Colville Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Colville Resource Advisory Committee will meet in..., presentation and voting of 2012 Colville Resource Advisory Committee projects. The full agenda may be previewed...

  13. 76 FR 85 - Coconino Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-03

    ... DEPARTMENT OF AGRICULTURE Forest Service Coconino Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Coconino Resource Advisory Committee will meet in... Resource Advisory Committee, c/o Forest Service, USDA, 1824 S. Thompson St., Flagstaff, Arizona 86001 or...

  14. 75 FR 65295 - Sitka Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-22

    ... DEPARTMENT OF AGRICULTURE Forest Service Sitka Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Sitka Resource Advisory Committee will meet in Sitka..., 204 Siginaka Way, Sitka, Alaska. Send written comments to Sitka Resource Advisory Committee, c/o...

  15. 77 FR 26774 - Homeland Security Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-07

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2012-0021] Homeland Security Advisory Council.... SUMMARY: The Homeland Security Advisory Council (HSAC) will meet in person and members of the public may...-9207. Mail: Homeland Security Advisory Council, Department of Homeland Security, Mailstop 0450, 245...

  16. 77 FR 67809 - Nuclear Energy Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-14

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Department of Energy, Office of Nuclear Energy. ACTION: Notice of Open Meeting. SUMMARY: This notice announces a meeting of the Nuclear Energy Advisory Committee (NEAC). Federal Advisory Committee Act requires that public notice of these...

  17. 76 FR 54747 - State Energy Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-02

    ... DEPARTMENT OF ENERGY Energy Efficiency and Renewable Energy State Energy Advisory Board AGENCY: Energy Efficiency and Renewable Energy, Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces an open meeting of the State Energy Advisory Board (STEAB). The Federal Advisory...

  18. 76 FR 2672 - Science Advisory Board Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-14

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration Science Advisory Board... forth the schedule and proposed agenda of a forthcoming meeting of the NOAA Science Advisory Board. The... CONTACT: Dr. Cynthia Decker, Executive Director, Science Advisory Board, NOAA, Rm. 11230, 1315 East-West...

  19. Antigen sensitivity of CD22-specific chimeric T cell receptors is modulated by target epitope distance from the cell membrane

    PubMed Central

    James, Scott E.; Greenberg, Philip D.; Jensen, Michael C.; Lin, Yukang; Wang, Jinjuan; Till, Brian G.; Raubitschek, Andrew A.; Forman, Stephen J.; Press, Oliver W.

    2008-01-01

    We have targeted CD22 as a novel tumor-associated antigen for recognition by human CTL genetically modified to express chimeric T cell receptors (cTCR) recognizing this surface molecule. CD22-specifc cTCR targeting different epitopes of the CD22 molecule promoted efficient lysis of target cells expressing high levels of CD22 with a maximum lytic potential that appeared to decrease as the distance of the target epitope from the target cell membrane increased. Targeting membrane-distal CD22 epitopes with cTCR+ CTL revealed defects in both degranulation and lytic granule targeting. CD22-specific cTCR+ CTL exhibited lower levels of maximum lysis and lower antigen sensitivity than CTL targeting CD20, which has a shorter extracellular domain than CD22. This diminished sensitivity was not a result of reduced avidity of antigen engagement, but instead reflected weaker signaling per triggered cTCR molecule when targeting membrane-distal epitopes of CD22. Both of these parameters were restored by targeting a ligand expressing the same epitope but constructed as a truncated CD22 molecule to approximate the length of a TCR:pMHC complex. The reduced sensitivity of CD22-specific cTCR+ CTL for antigen-induced triggering of effector functions has potential therapeutic applications, as such cells selectively lysed B cell lymphoma lines expressing high levels of CD22 but demonstrated minimal activity against autologous normal B cells, which express lower levels of CD22. Thus, our results demonstrate that cTCR signal strength – and consequently antigen sensitivity – can be modulated by differential choice of target epitopes with respect to distance from the cell membrane, allowing discrimination between targets with disparate antigen density. PMID:18453625

  20. Applied Genomics: Data Mining Reveals Species-Specific Malaria Diagnostic Targets More Sensitive than 18S rRNA▿†‡

    PubMed Central

    Demas, Allison; Oberstaller, Jenna; DeBarry, Jeremy; Lucchi, Naomi W.; Srinivasamoorthy, Ganesh; Sumari, Deborah; Kabanywanyi, Abdunoor M.; Villegas, Leopoldo; Escalante, Ananias A.; Kachur, S. Patrick; Barnwell, John W.; Peterson, David S.; Udhayakumar, Venkatachalam; Kissinger, Jessica C.

    2011-01-01

    Accurate and rapid diagnosis of malaria infections is crucial for implementing species-appropriate treatment and saving lives. Molecular diagnostic tools are the most accurate and sensitive method of detecting Plasmodium, differentiating between Plasmodium species, and detecting subclinical infections. Despite available whole-genome sequence data for Plasmodium falciparum and P. vivax, the majority of PCR-based methods still rely on the 18S rRNA gene targets. Historically, this gene has served as the best target for diagnostic assays. However, it is limited in its ability to detect mixed infections in multiplex assay platforms without the use of nested PCR. New diagnostic targets are needed. Ideal targets will be species specific, highly sensitive, and amenable to both single-step and multiplex PCRs. We have mined the genomes of P. falciparum and P. vivax to identify species-specific, repetitive sequences that serve as new PCR targets for the detection of malaria. We show that these targets (Pvr47 and Pfr364) exist in 14 to 41 copies and are more sensitive than 18S rRNA when utilized in a single-step PCR. Parasites are routinely detected at levels of 1 to 10 parasites/μl. The reaction can be multiplexed to detect both species in a single reaction. We have examined 7 P. falciparum strains and 91 P. falciparum clinical isolates from Tanzania and 10 P. vivax strains and 96 P. vivax clinical isolates from Venezuela, and we have verified a sensitivity and specificity of ∼100% for both targets compared with a nested 18S rRNA approach. We show that bioinformatics approaches can be successfully applied to identify novel diagnostic targets and improve molecular methods for pathogen detection. These novel targets provide a powerful alternative molecular diagnostic method for the detection of P. falciparum and P. vivax in conventional or multiplex PCR platforms. PMID:21525225

  1. 29 CFR 1912.36 - Advice of advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... members of an advisory committee shall not be a reason for not giving advice to the Assistant Secretary... 29 Labor 7 2010-07-01 2010-07-01 false Advice of advisory committees. 1912.36 Section 1912.36... Advice of advisory committees. (a) Approval by a majority of all members of an advisory committee is...

  2. 29 CFR 1912.36 - Advice of advisory committees.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... members of an advisory committee shall not be a reason for not giving advice to the Assistant Secretary... 29 Labor 7 2011-07-01 2011-07-01 false Advice of advisory committees. 1912.36 Section 1912.36... Advice of advisory committees. (a) Approval by a majority of all members of an advisory committee is...

  3. 45 CFR 1222.4 - Advisory group responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false Advisory group responsibilities. 1222.4 Section... COMMUNITY SERVICE PARTICIPATION OF PROJECT BENEFICIARIES § 1222.4 Advisory group responsibilities. The advisory group shall have the following responsibilities for the intent and purposes of these requirements...

  4. 45 CFR 1222.4 - Advisory group responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false Advisory group responsibilities. 1222.4 Section... COMMUNITY SERVICE PARTICIPATION OF PROJECT BENEFICIARIES § 1222.4 Advisory group responsibilities. The advisory group shall have the following responsibilities for the intent and purposes of these requirements...

  5. 45 CFR 1222.4 - Advisory group responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false Advisory group responsibilities. 1222.4 Section... COMMUNITY SERVICE PARTICIPATION OF PROJECT BENEFICIARIES § 1222.4 Advisory group responsibilities. The advisory group shall have the following responsibilities for the intent and purposes of these requirements...

  6. 16 CFR 1018.61 - Statutory advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Statutory advisory committees. 1018.61 Section 1018.61 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ADVISORY COMMITTEE MANAGEMENT Termination and Renewal § 1018.61 Statutory advisory committees. A new charter shall be filed for...

  7. 45 CFR 1222.4 - Advisory group responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Advisory group responsibilities. 1222.4 Section... COMMUNITY SERVICE PARTICIPATION OF PROJECT BENEFICIARIES § 1222.4 Advisory group responsibilities. The advisory group shall have the following responsibilities for the intent and purposes of these requirements...

  8. 78 FR 54680 - NASA Federal Advisory Committees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-05

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: 13-109] NASA Federal Advisory Committees... by U.S. Citizens for Service on NASA Federal Advisory Committees. SUMMARY: NASA announces its annual invitation for public nominations for service on NASA Federal advisory committees. U.S. citizens may nominate...

  9. 75 FR 20371 - Homeland Security Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-19

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2010-0030] Homeland Security Advisory Council... Meeting. SUMMARY: The Homeland Security Advisory Council (HSAC) will meet via teleconference for the... number in the subject line of the message. Fax: (202) 282-9207 Mail: Homeland Security Advisory Council...

  10. 75 FR 67351 - Environmental Management Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-02

    ... DEPARTMENT OF ENERGY Environmental Management Advisory Board AGENCY: Department of Energy. ACTION... Management Advisory Board (EMAB). The Federal Advisory Committee Act (Pub. L. No. 92-463, 86 Stat. 770... Management (EM) with advice and recommendations on corporate issues confronting the EM program. EMAB will...

  11. 75 FR 7255 - Army Educational Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-18

    ... DEPARTMENT OF DEFENSE Department of the Army Army Educational Advisory Committee AGENCY: Department of the Army, DoD. ACTION: Notice of open meeting. SUMMARY: Pursuant to the Federal Advisory... Committee: U.S. Army War College Subcommittee of the Army Education Advisory Committee. Date of Meeting...

  12. 76 FR 72914 - Army Educational Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... DEPARTMENT OF DEFENSE Department of the Army Army Educational Advisory Committee AGENCY: Department of the Army, DoD. ACTION: Notice of open meeting. SUMMARY: Pursuant to the Federal Advisory...: U.S. Army War College Subcommittee of the Army Education Advisory Committee. Dates of Meeting...

  13. 76 FR 12087 - Army Educational Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-04

    ... DEPARTMENT OF DEFENSE Department of the Army Army Educational Advisory Committee AGENCY: Department of the Army, DoD. ACTION: Notice of open meeting. SUMMARY: Pursuant to the Federal Advisory...: U.S. Army War College Subcommittee of the Army Education Advisory Committee. Dates of Meeting: March...

  14. 75 FR 67351 - Nuclear Energy Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-02

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Office of Nuclear Energy, Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Nuclear Energy Advisory Committee (NEAC). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770...

  15. 78 FR 29125 - Nuclear Energy Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-17

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Office of Nuclear Energy, Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Nuclear Energy Advisory Committee (NEAC). Federal Advisory Committee Act (Pub. L. 94-463, 86 Stat. 770) requires...

  16. 76 FR 67717 - Nuclear Energy Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-02

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Department of Energy, Office of Nuclear Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Nuclear Energy Advisory Committee (NEAC). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770...

  17. 75 FR 13269 - Nuclear Energy Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-19

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Department of Energy, Office of Nuclear Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Nuclear Energy Advisory Committee (NEAC). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770...

  18. 77 FR 26274 - Nuclear Energy Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-03

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Department of Energy, Office of Nuclear Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Nuclear Energy Advisory Committee (NEAC). The Federal Advisory Committee Act (Pub. Law 92-463, 86 Stat. 770...

  19. 75 FR 56997 - Global Markets Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-17

    ... COMMODITY FUTURES TRADING COMMISSION Global Markets Advisory Committee AGENCY: Commodity Futures Trading Commission (``CFTC''). ACTION: Notice of meeting of Global Markets Advisory Committee. SUMMARY: The Global Markets Advisory Committee will hold a public meeting on October 5, 2010, from 1 p.m. to 5...

  20. 75 FR 58367 - Technology Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-24

    ... COMMODITY FUTURES TRADING COMMISSION Technology Advisory Committee Meeting AGENCY: Commodity Futures Trading Commission (``CFTC''). ACTION: Notice of meeting of Technology Advisory Committee. SUMMARY: The Technology Advisory Committee will hold a public meeting on October 12, 2010, from 1 p.m. to 5 p.m...

  1. 22 CFR 8.9 - Meetings of advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Meetings of advisory committees. 8.9 Section 8.9 Foreign Relations DEPARTMENT OF STATE GENERAL ADVISORY COMMITTEE MANAGEMENT § 8.9 Meetings of advisory committees. (a) Applicability. The term “meeting” covers any situation in which all or some of the members of an advisory committee convene with...

  2. 78 FR 11899 - Invasive Species Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-20

    ... DEPARTMENT OF THE INTERIOR Office of the Secretary Invasive Species Advisory Committee AGENCY... notice of public meetings of the Invasive Species Advisory Committee. The document contained incorrect..., March 6, 2013; 9 a.m. to 1:45 p.m. Meeting of the Invasive Species Advisory Committee (OPEN): Thursday...

  3. 36 CFR 242.12 - Local advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Local advisory committees... SUBSISTENCE MANAGEMENT REGULATIONS FOR PUBLIC LANDS IN ALASKA Program Structure § 242.12 Local advisory committees. (a) The Board shall establish such local Federal Advisory Committees within each region as...

  4. 36 CFR 242.12 - Local advisory committees.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Local advisory committees... SUBSISTENCE MANAGEMENT REGULATIONS FOR PUBLIC LANDS IN ALASKA Program Structure § 242.12 Local advisory committees. (a) The Board shall establish such local Federal Advisory Committees within each region as...

  5. 76 FR 2081 - Ketchikan Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-12

    ... Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Ketchikan Resource Advisory Committee will meet in Ketchikan, Alaska, March 29, 2011. The purpose of this meeting is... written comments to Ketchikan Resource Advisory Committee, c/o District Ranger, USDA Forest Service, 3031...

  6. 76 FR 31935 - Juneau Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-02

    ... DEPARTMENT OF AGRICULTURE Forest Service Juneau Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Juneau Resource Advisory Committee will meet in Juneau... Atadero, Juneau Resource Advisory Committee, PO Box 21628, Juneau, AK 99802, or by e-mail to [email protected

  7. 29 CFR 1430.8 - Advisory committee meetings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Advisory committee meetings. 1430.8 Section 1430.8 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE FEDERAL MEDIATION AND CONCILIATION SERVICE ADVISORY COMMITTEES § 1430.8 Advisory committee meetings. (a) Initiation of meetings. (1...

  8. 78 FR 70932 - Nuclear Energy Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Office of Nuclear Energy, Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Nuclear Energy Advisory Committee (NEAC). The Federal Advisory Committee Act (Public Law No. 94-463, 86 Stat. 770...

  9. 75 FR 22561 - Federal Advisory Committee; United States Strategic Command Strategic Advisory Group; Charter...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-29

    ... Command Strategic Advisory Group; Charter Renewal AGENCY: Department of Defense (DoD). ACTION: Renewal of... Command Strategic Advisory Group (hereafter referred to as the Group). FOR FURTHER INFORMATION CONTACT... Chairman of the Joint Chiefs of Staff and the Commander of the U.S. Strategic Command independent advice...

  10. Multifunctional pH-sensitive superparamagnetic iron-oxide nanocomposites for targeted drug delivery and MR imaging.

    PubMed

    Zhu, Lijuan; Wang, Dali; Wei, Xuan; Zhu, Xinyuan; Li, Jianqi; Tu, Chunlai; Su, Yue; Wu, Jieli; Zhu, Bangshang; Yan, Deyue

    2013-08-10

    A multifunctional pH-sensitive superparamagnetic iron-oxide (SPIO) nanocomposite system was developed for simultaneous tumor magnetic resonance imaging (MRI) and therapy. Small-size SPIO nanoparticles were chemically bonded with antitumor drug doxorubicin (DOX) and biocompatible poly(ethylene glycol) (PEG) through pH-sensitive acylhydrazone linkages, resulting in the formation of SPIO nanocomposites with magnetic targeting and pH-sensitive properties. These DOX-conjugated SPIO nanocomposites exhibited not only good stability in aqueous solution but also high saturation magnetizations. Under an acidic environment, the DOX was quickly released from the SPIO nanocomposites due to the cleavage of pH-sensitive acylhydrazone linkages. With the help of magnetic field, the DOX-conjugated SPIO nanocomposites showed high cellular uptake, indicating their magnetic targeting property. Comparing to free DOX, the DOX-conjugated SPIO nanocomposites showed better antitumor effect under magnetic field. At the same time, the relaxivity value of these SPIO nanocomposites was higher than 146s(-1)mM(-1) Fe, leading to ~4 times enhancement compared to that of free SPIO nanoparticles. As a negative contrast agent, these SPIO nanocomposites illustrated high resolution in MRI diagnosis of tumor-bearing mice. All of these results confirm that these pH-sensitive SPIO nanocomposites are promising hybrid materials for synergistic MRI diagnosis and tumor therapy. Copyright © 2013 Elsevier B.V. All rights reserved.

  11. pH-sensitive oncolytic adenovirus hybrid targeting acidic tumor microenvironment and angiogenesis

    PubMed Central

    Choi, Joung-Woo; Jung, Soo-Jung; Kasala, Dayananda; Hwang, June Kyu; Hu, Jun; Bae, You Han; Yun, Chae-Ok

    2015-01-01

    Although oncolytic adenoviruses (Ads) are an attractive option for cancer gene therapy, the intravenous administration of naked Ad still encounters unfavorable host responses, non-specific interactions, and heterogeneity in targeted cancer cells. To overcome these obstacles and achieve specific targeting of the tumor microenvironment, Ad was coated with the pH-sensitive block copolymer, methoxy poly(ethylene glycol)-b-poly(l-histidine-co-l-phenylalanine) (PEGbPHF). The physicochemical properties of the generated nanocomplex, Ad/PEGbPHF, were assessed. At pH 6.4, GFP-expressing Ad/PEGbPHF induced significantly higher GFP expression than naked Ad in both coxsackie and adenovirus receptor (CAR)-positive and -negative cells. To assess the therapeutic efficacy of the Ad/PEGbPHF complex platform, an oncolytic Ad expressing VEGF promoter-targeting transcriptional repressor (KOX) was used to form complexes. At pH 6.4, KOX/PEGbPHF significantly suppressed VEGF gene expression, cancer cell migration, vessel sprouting, and cancer cell killing effect compared to naked KOX or KOX/PEGbPHF at pH 7.4, demonstrating that KOX/PEGbPHF can overcome the lack of CAR that is frequently observed in tumor tissues. The antitumor activity of KOX/PEGbPHF systemically administered to a tumor xenograft model was significantly higher than that of naked KOX. Furthermore, KOX/PEGbPHF showed lower hepatic toxicity and did not induce an innate immune response against Ad. Altogether, these results demonstrate that pH-sensitive polymer-coated Ad complex significantly increases net positive charge upon exposure to hypoxic tumor microenvironment, allowing passive targeting to the tumor tissue. It may offer superior potential for systemic therapy, due to its improved tumor selectivity, increased therapeutic efficacy, and lower toxicity compared to naked KOX. PMID:25575865

  12. 78 FR 45496 - Flathead Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-29

    ... DEPARTMENT OF AGRICULTURE Forest Service Flathead Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meetings. SUMMARY: The Flathead Resource Advisory Committee will meet in.... September 24, 2013--4:00 p.m. to 6:30 p.m. All Resource Advisory Committee meetings are subject to change or...

  13. 36 CFR 219.25 - Science advisory boards.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Science advisory boards. 219... PLANNING National Forest System Land and Resource Management Planning The Contribution of Science § 219.25 Science advisory boards. (a) National science advisory board. The Forest Service Deputy Chief for Research...

  14. 36 CFR 219.25 - Science advisory boards.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Science advisory boards. 219... PLANNING National Forest System Land and Resource Management Planning The Contribution of Science § 219.25 Science advisory boards. (a) National science advisory board. The Forest Service Deputy Chief for Research...

  15. 78 FR 20685 - Aviation Security Advisory Committee (ASAC) Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ... DEPARTMENT OF HOMELAND SECURITY Transportation Security Administration Aviation Security Advisory...; Notice of Closed Federal Advisory Committee Meeting. SUMMARY: The Aviation Security Advisory Committee... Committee Act, 5 U.S.C. App. (Pub. L. 92-463). The Aviation Security Advisory Committee (ASAC) provides...

  16. Targeting cholesterol synthesis increases chemoimmuno-sensitivity in chronic lymphocytic leukemia cells.

    PubMed

    Benakanakere, Indira; Johnson, Tyler; Sleightholm, Richard; Villeda, Virgilio; Arya, Monika; Bobba, Ravi; Freter, Carl; Huang, Chunfa

    2014-01-01

    Cholesterol plays an important role in cancer development, drug resistance and chemoimmuno-sensitivity. Statins, cholesterol lowering drugs, can induce apoptosis, but also negatively interfere with CD-20 and rituximab-mediated activity. Our goal is to identify the alternative targets that could reduce cholesterol levels but do not interfere with CD-20 in chemo immunotherapy of chronic lymphocytic leukemia (CLL). MEC-2 cells, a CLL cell line, and the peripheral blood mononuclear cells (PBMCs) from CLL patients were treated with cholesterol lowering agents, and analyzed the effect of these agents on cholesterol levels, CD-20 expression and distribution, and cell viability in the presence or absence of fludarabine, rituximab or their combinations. We found that MEC-2 cells treated with cholesterol lowering agents (BIBB-515, YM-53601 or TAK-475) reduced 20% of total cellular cholesterol levels, but also significantly promoted CD-20 surface expression. Furthermore, treatment of cells with fludarabine, rituximab or their combinations in the presence of BIBB-515, YM-53601 or TAK-475 enhanced MEC-2 cell chemoimmuno-sensitivity measured by cell viability. More importantly, these cholesterol lowering agents also significantly enhanced chemoimmuno-sensitivity of the PBMCs from CLL patients. Our data demonstrate that BIBB-515, YM53601 and TAK-475 render chemoimmuno-therapy resistant MEC-2 cells sensitive to chemoimmuno-therapy and enhance CLL cell chemoimmuno-sensitivity without CD-20 epitope presentation or its downstream signaling. These results provide a novel strategy which could be applied to CLL treatment.

  17. 76 FR 64122 - NASA Advisory Committee; Renewal of NASA's International Space Station Advisory Committee Charter

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-17

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (11-095)] NASA Advisory Committee; Renewal of NASA's International Space Station Advisory Committee Charter AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of renewal and amendment of the Charter of the International...

  18. National and Governmental Advisory Committees: Meetings

    EPA Pesticide Factsheets

    Meetings and Teleconference Information for the National Advisory Committee and Governmental Advisory Committee to the United States Representative to the North American Commission for Environmental Cooperation,

  19. 16 CFR 1018.14 - Non-Commission established advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Non-Commission established advisory committees. 1018.14 Section 1018.14 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ADVISORY COMMITTEE MANAGEMENT Establishment of Advisory Committees § 1018.14 Non-Commission established advisory...

  20. 21 CFR 20.118 - Advisory committee records.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Advisory committee records. 20.118 Section 20.118 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PUBLIC INFORMATION Availability of Specific Categories of Records § 20.118 Advisory committee records. All advisory...

  1. 36 CFR 219.18 - Role of advisory committees.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... PLANNING National Forest System Land and Resource Management Planning Collaborative Planning for Sustainability § 219.18 Role of advisory committees. (a) Advisory committees. Advisory committees can provide an...)). Ecological, Social, and Economic Sustainability ...

  2. Sensitive and Specific Target Sequences Selected from Retrotransposons of Schistosoma japonicum for the Diagnosis of Schistosomiasis

    PubMed Central

    Xu, Jing; Zhu, Xing-Quan; Wang, Sheng-Yue; Xia, Chao-Ming

    2012-01-01

    Background Schistosomiasis japonica is a serious debilitating and sometimes fatal disease. Accurate diagnostic tests play a key role in patient management and control of the disease. However, currently available diagnostic methods are not ideal, and the detection of the parasite DNA in blood samples has turned out to be one of the most promising tools for the diagnosis of schistosomiasis. In our previous investigations, a 230-bp sequence from the highly repetitive retrotransposon SjR2 was identified and it showed high sensitivity and specificity for detecting Schistosoma japonicum DNA in the sera of rabbit model and patients. Recently, 29 retrotransposons were found in S. japonicum genome by our group. The present study highlighted the key factors for selecting a new perspective sensitive target DNA sequence for the diagnosis of schistosomiasis, which can serve as example for other parasitic pathogens. Methodology/Principal Findings In this study, we demonstrated that the key factors based on the bioinformatic analysis for selecting target sequence are the higher genome proportion, repetitive complete copies and partial copies, and active ESTs than the others in the chromosome genome. New primers based on 25 novel retrotransposons and SjR2 were designed and their sensitivity and specificity for detecting S. japonicum DNA were compared. The results showed that a new 303-bp sequence from non-long terminal repeat (LTR) retrotransposon (SjCHGCS19) had high sensitivity and specificity. The 303-bp target sequence was amplified from the sera of rabbit model at 3 d post-infection by nested-PCR and it became negative at 17 weeks post-treatment. Furthermore, the percentage sensitivity of the nested-PCR was 97.67% in 43 serum samples of S. japonicum-infected patients. Conclusions/Significance Our findings highlighted the key factors based on the bioinformatic analysis for selecting target sequence from S. japonicum genome, which provide basis for establishing powerful

  3. Linchpins or Lost Time: Creating Effective Advisories

    ERIC Educational Resources Information Center

    Johnson, Bil

    2009-01-01

    That advisories in secondary schools are fairly pervasive around the country may be one of the great unintended consequences of the Coalition of Essential Schools (CES) reform effort. While no CES Common Principle explicitly states that advisories should exist in schools, as Coalition Schools evolved, advisories became one of the logical ways for…

  4. 75 FR 18470 - Olympic National Forest; Federal Register-Title II Resource Advisory Committee Meeting Advisory

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-12

    ... DEPARTMENT OF AGRICULTURE Forest Service Olympic National Forest; Federal Register--Title II Resource Advisory Committee Meeting Advisory AGENCY: Olympic National Forest, USDA Forest Service. ACTION... recommendations for Title II projects to be funded by the Secure Rural Schools and Community Self- Determination...

  5. The California Earthquake Advisory Plan: A history

    USGS Publications Warehouse

    Roeloffs, Evelyn A.; Goltz, James D.

    2017-01-01

    Since 1985, the California Office of Emergency Services (Cal OES) has issued advisory statements to local jurisdictions and the public following seismic activity that scientists on the California Earthquake Prediction Evaluation Council view as indicating elevated probability of a larger earthquake in the same area during the next several days. These advisory statements are motivated by statistical studies showing that about 5% of moderate earthquakes in California are followed by larger events within a 10-km, five-day space-time window (Jones, 1985; Agnew and Jones, 1991; Reasenberg and Jones, 1994). Cal OES issued four earthquake advisories from 1985 to 1989. In October, 1990, the California Earthquake Advisory Plan formalized this practice, and six Cal OES Advisories have been issued since then. This article describes that protocol’s scientific basis and evolution.

  6. A Guide for Planning, Organizing, and Utilizing Advisory Councils.

    ERIC Educational Resources Information Center

    Illinois State Office of Education, Springfield. Div. of Vocational and Technical Education.

    Designed for administrators and teachers at the community college/secondary/elementary levels, the guide is a reference source for establishing and developing citizen advisory councils. A section on Advisory Councils--Planning discusses the need for citizen advisory councils, definition and purpose, advisory council types, and operational…

  7. 75 FR 48320 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-10

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Department of... of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act.... SUPPLEMENTARY INFORMATION: Purpose of the Committee: The purpose of the Unconventional Resources Technology...

  8. 77 FR 53191 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-31

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Department of... of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act.... SUPPLEMENTARY INFORMATION: Purpose of the Committee: The purpose of the Unconventional Resources Technology...

  9. 42 CFR 90.9 - Public health advisory.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Public health advisory. 90.9 Section 90.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH... PROCEDURES § 90.9 Public health advisory. ATSDR may issue a public health advisory based on the findings of a...

  10. 42 CFR 90.9 - Public health advisory.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Public health advisory. 90.9 Section 90.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH... PROCEDURES § 90.9 Public health advisory. ATSDR may issue a public health advisory based on the findings of a...

  11. 42 CFR 90.9 - Public health advisory.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Public health advisory. 90.9 Section 90.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH... PROCEDURES § 90.9 Public health advisory. ATSDR may issue a public health advisory based on the findings of a...

  12. 42 CFR 90.9 - Public health advisory.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Public health advisory. 90.9 Section 90.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH... PROCEDURES § 90.9 Public health advisory. ATSDR may issue a public health advisory based on the findings of a...

  13. 42 CFR 90.9 - Public health advisory.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Public health advisory. 90.9 Section 90.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH... PROCEDURES § 90.9 Public health advisory. ATSDR may issue a public health advisory based on the findings of a...

  14. 32 CFR 1698.2 - Requests for advisory opinions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ADVISORY OPINIONS § 1698.2 Requests for advisory opinions. (a) Any male born after December 31, 1959 who... advisory opinion as to the liability of any male person born after December 31, 1959 who has attained 18...

  15. 32 CFR 1698.2 - Requests for advisory opinions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ADVISORY OPINIONS § 1698.2 Requests for advisory opinions. (a) Any male born after December 31, 1959 who... advisory opinion as to the liability of any male person born after December 31, 1959 who has attained 18...

  16. 78 FR 1265 - Aerospace Safety Advisory Panel; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 13-001] Aerospace Safety Advisory Panel... Aeronautics and Space Administration announces a forthcoming meeting of the Aerospace Safety Advisory Panel..., Aerospace Safety Advisory Panel Executive Director, National Aeronautics and Space Administration...

  17. 76 FR 62455 - Aerospace Safety Advisory Panel; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (11-088)] Aerospace Safety Advisory Panel... Aeronautics and Space Administration announces a forthcoming meeting of the Aerospace Safety Advisory Panel... Burch, Aerospace Safety Advisory Panel Administrative Officer, National Aeronautics and Space...

  18. 77 FR 10485 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-22

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Office of... meeting of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act.... SUPPLEMENTARY INFORMATION: Purpose of the Committee: The purpose of the Unconventional Resources Technology...

  19. 76 FR 64923 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-19

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Office of... meeting of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act.... SUPPLEMENTARY INFORMATION: Purpose of the Committee: The purpose of the Unconventional Resources Technology...

  20. 10 CFR 7.17 - Reports required for advisory committees.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Reports required for advisory committees. 7.17 Section 7.17 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.17 Reports required for advisory committees. (a) The Commission shall furnish a report on the activities of NRC advisory committees annually...

  1. 10 CFR 7.17 - Reports required for advisory committees.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Reports required for advisory committees. 7.17 Section 7.17 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.17 Reports required for advisory committees. (a) The Commission shall furnish a report on the activities of NRC advisory committees annually...

  2. 10 CFR 7.17 - Reports required for advisory committees.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Reports required for advisory committees. 7.17 Section 7.17 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.17 Reports required for advisory committees. (a) The Commission shall furnish a report on the activities of NRC advisory committees annually...

  3. 10 CFR 7.17 - Reports required for advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Reports required for advisory committees. 7.17 Section 7.17 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.17 Reports required for advisory committees. (a) The Commission shall furnish a report on the activities of NRC advisory committees annually...

  4. 10 CFR 7.17 - Reports required for advisory committees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Reports required for advisory committees. 7.17 Section 7.17 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.17 Reports required for advisory committees. (a) The Commission shall furnish a report on the activities of NRC advisory committees annually...

  5. Non-Alumni Advisory Board Volunteers

    ERIC Educational Resources Information Center

    Nagai, Judy; Nehls, Kimberly

    2014-01-01

    Advisory boards typically offer guidance, support, social, and financial capital to academic units within colleges and universities. They are generally comprised of prominent volunteers from the community and appropriate industries or businesses. The results of this exploratory study found that non-alumni advisory board volunteers developed…

  6. 75 FR 52732 - Renewal of Department of Defense Federal Advisory Committee; Missile Defense Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-27

    ... DEPARTMENT OF DEFENSE Office of the Secretary Renewal of Department of Defense Federal Advisory Committee; Missile Defense Advisory Committee AGENCY: Department of Defense (DoD). ACTION: Renewal of..., the Department of Defense gives notice that it is renewing the charter for the Missile Defense...

  7. Automated Pilot Advisory System

    NASA Technical Reports Server (NTRS)

    Parks, J. L., Jr.; Haidt, J. G.

    1981-01-01

    An Automated Pilot Advisory System (APAS) was developed and operationally tested to demonstrate the concept that low cost automated systems can provide air traffic and aviation weather advisory information at high density uncontrolled airports. The system was designed to enhance the see and be seen rule of flight, and pilots who used the system preferred it over the self announcement system presently used at uncontrolled airports.

  8. pH-Sensitive stimulus-responsive nanocarriers for targeted delivery of therapeutic agents

    PubMed Central

    Karimi, Mahdi; Eslami, Masoud; Sahandi-Zangabad, Parham; Mirab, Fereshteh; Farajisafiloo, Negar; Shafaei, Zahra; Ghosh, Deepanjan; Bozorgomid, Mahnaz; Dashkhaneh, Fariba; Hamblin, Michael R.

    2016-01-01

    In recent years miscellaneous smart micro/nanosystems that respond to various exogenous/endogenous stimuli including temperature, magnetic/electric field, mechanical force, ultrasound/light irradiation, redox potentials, and biomolecule concentration have been developed for targeted delivery and release of encapsulated therapeutic agents such as drugs, genes, proteins, and metal ions specifically at their required site of action. Owing to physiological differences between malignant and normal cells, or between tumors and normal tissues, pH-sensitive nanosystems represent promising smart delivery vehicles for transport and delivery of anticancer agents. Furthermore, pH-sensitive systems possess applications in delivery of metal ions and biomolecules such as proteins, insulin, etc., as well as co-delivery of cargos, dual pH-sensitive nanocarriers, dual/multi stimuli-responsive nanosystems, and even in the search for new solutions for therapy of diseases such as Alzheimer’s. In order to design an optimized system, it is necessary to understand the various pH-responsive micro/nanoparticles and the different mechanisms of pH-sensitive drug release. This should be accompanied by an assessment of the theoretical and practical challenges in the design and use of these carriers. PMID:26762467

  9. 75 FR 61219 - Aerospace Safety Advisory Panel; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-04

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-116)] Aerospace Safety Advisory Panel... Aeronautics and Space Administration announces a forthcoming meeting of the Aerospace Safety Advisory Panel... Dakon, Aerospace Safety Advisory Panel Executive Director, National Aeronautics and Space Administration...

  10. 76 FR 19147 - Aerospace Safety Advisory Panel; Meeting.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (11-030)] Aerospace Safety Advisory Panel... Aeronautics and Space Administration announce a forthcoming meeting of the Aerospace Safety Advisory Panel.... Kathy Dakon, Aerospace Safety Advisory Panel Executive Director, National Aeronautics and Space...

  11. 78 FR 56941 - Aerospace Safety Advisory Panel; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-16

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: 13-114] Aerospace Safety Advisory Panel... Aeronautics and Space Administration announces a forthcoming meeting of the Aerospace Safety Advisory Panel.... Harmony Myers, Aerospace Safety Advisory Panel Executive Director, National Aeronautics and Space...

  12. 77 FR 58413 - Aerospace Safety Advisory Panel; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-20

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 12-074] Aerospace Safety Advisory Panel... Aeronautics and Space Administration announces a forthcoming meeting of the Aerospace Safety Advisory Panel.... Harmony Myers, Aerospace Safety Advisory Panel Executive Director, National Aeronautics and Space...

  13. 77 FR 38090 - Aerospace Safety Advisory Panel; Meeting.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-26

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 12-044] Aerospace Safety Advisory Panel... Aeronautics and Space Administration announces a forthcoming meeting of the Aerospace Safety Advisory Panel.... Harmony Myers, Aerospace Safety Advisory Panel Executive Director, National Aeronautics and Space...

  14. 10 CFR 7.13 - Minutes of advisory committee meetings.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Minutes of advisory committee meetings. 7.13 Section 7.13 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.13 Minutes of advisory committee meetings. (a) Detailed minutes shall be kept of each NRC advisory committee meeting. The minutes shall include...

  15. 10 CFR 7.6 - Amendment to advisory committee charters.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Amendment to advisory committee charters. 7.6 Section 7.6 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.6 Amendment to advisory committee charters. (a) Final authority for amending the charter of an NRC advisory committee established or utilized by...

  16. 10 CFR 7.6 - Amendment to advisory committee charters.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Amendment to advisory committee charters. 7.6 Section 7.6 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.6 Amendment to advisory committee charters. (a) Final authority for amending the charter of an NRC advisory committee established or utilized by...

  17. 10 CFR 7.19 - Advisory committee members with disabilities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Advisory committee members with disabilities. 7.19 Section 7.19 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.19 Advisory committee members with disabilities. An NRC advisory committee member who is disabled may be provided services by a personal assistant...

  18. 10 CFR 7.6 - Amendment to advisory committee charters.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Amendment to advisory committee charters. 7.6 Section 7.6 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.6 Amendment to advisory committee charters. (a) Final authority for amending the charter of an NRC advisory committee established or utilized by...

  19. 10 CFR 7.13 - Minutes of advisory committee meetings.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Minutes of advisory committee meetings. 7.13 Section 7.13 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.13 Minutes of advisory committee meetings. (a) Detailed minutes shall be kept of each NRC advisory committee meeting. The minutes shall include...

  20. 10 CFR 7.13 - Minutes of advisory committee meetings.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Minutes of advisory committee meetings. 7.13 Section 7.13 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.13 Minutes of advisory committee meetings. (a) Detailed minutes shall be kept of each NRC advisory committee meeting. The minutes shall include...

  1. 10 CFR 7.19 - Advisory committee members with disabilities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Advisory committee members with disabilities. 7.19 Section 7.19 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.19 Advisory committee members with disabilities. An NRC advisory committee member who is disabled may be provided services by a personal assistant...

  2. 10 CFR 7.19 - Advisory committee members with disabilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Advisory committee members with disabilities. 7.19 Section 7.19 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.19 Advisory committee members with disabilities. An NRC advisory committee member who is disabled may be provided services by a personal assistant...

  3. 10 CFR 7.13 - Minutes of advisory committee meetings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Minutes of advisory committee meetings. 7.13 Section 7.13 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.13 Minutes of advisory committee meetings. (a) Detailed minutes shall be kept of each NRC advisory committee meeting. The minutes shall include...

  4. 10 CFR 7.6 - Amendment to advisory committee charters.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Amendment to advisory committee charters. 7.6 Section 7.6 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.6 Amendment to advisory committee charters. (a) Final authority for amending the charter of an NRC advisory committee established or utilized by...

  5. 10 CFR 7.19 - Advisory committee members with disabilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Advisory committee members with disabilities. 7.19 Section 7.19 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.19 Advisory committee members with disabilities. An NRC advisory committee member who is disabled may be provided services by a personal assistant...

  6. 10 CFR 7.6 - Amendment to advisory committee charters.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Amendment to advisory committee charters. 7.6 Section 7.6 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.6 Amendment to advisory committee charters. (a) Final authority for amending the charter of an NRC advisory committee established or utilized by...

  7. 10 CFR 7.19 - Advisory committee members with disabilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Advisory committee members with disabilities. 7.19 Section 7.19 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.19 Advisory committee members with disabilities. An NRC advisory committee member who is disabled may be provided services by a personal assistant...

  8. 10 CFR 7.13 - Minutes of advisory committee meetings.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Minutes of advisory committee meetings. 7.13 Section 7.13 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.13 Minutes of advisory committee meetings. (a) Detailed minutes shall be kept of each NRC advisory committee meeting. The minutes shall include...

  9. 78 FR 3498 - Debt Management Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-16

    ... DEPARTMENT OF THE TREASURY Departmental Offices Debt Management Advisory Committee Meeting Notice.... of the following debt management advisory committee: Treasury Borrowing Advisory Committee of The... decisions on major financing operations. Historically, this advice has been offered by debt management...

  10. 75 FR 16438 - U.S. Travel and Tourism Advisory Board: Meeting of the U.S. Travel and Tourism Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... DEPARTMENT OF COMMERCE International Trade Administration U.S. Travel and Tourism Advisory Board: Meeting of the U.S. Travel and Tourism Advisory Board AGENCY: International Trade Administration, U.S... Tourism Advisory Board (Board) will hold a meeting to discuss topics related to the travel and tourism...

  11. 75 FR 14135 - U.S. Travel And Tourism Advisory Board: Meeting of the U.S. Travel and Tourism Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-24

    ... DEPARTMENT OF COMMERCE International Trade Administration U.S. Travel And Tourism Advisory Board: Meeting of the U.S. Travel and Tourism Advisory Board AGENCY: International Trade Administration, U.S. Department of Commerce. ACTION: Notice of an open meeting. SUMMARY: The U.S. Travel and Tourism Advisory...

  12. 75 FR 39496 - U.S. Travel and Tourism Advisory Board: Meeting of the U.S. Travel and Tourism Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-09

    ... DEPARTMENT OF COMMERCE International Trade Administration U.S. Travel and Tourism Advisory Board: Meeting of the U.S. Travel and Tourism Advisory Board AGENCY: International Trade Administration, U.S. Department of Commerce. ACTION: Notice of an open meeting. SUMMARY: The U.S. Travel and Tourism Advisory...

  13. 77 FR 56242 - Dodd-Frank Investor Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-12

    ... Investor Advisory Committee AGENCY: Securities and Exchange Commission. ACTION: Notice of Meeting of Securities and Exchange Commission Dodd- Frank Investor Advisory Committee. SUMMARY: The Securities and Exchange Commission Investor Advisory Committee, established pursuant to Section 911 of the Dodd-Frank Wall...

  14. 77 FR 11084 - Army Education Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-24

    ... DEPARTMENT OF DEFENSE Department of the Army Army Education Advisory Committee Meeting AGENCY... the Army announces the following committee meeting: Name of Committee: Army Education Advisory... , (757) 501-5810, or to the following address: Army Education Advisory Committee, Designated Federal...

  15. 77 FR 50089 - Army Education Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-20

    ... DEPARTMENT OF DEFENSE Department of the Army Army Education Advisory Committee Meeting AGENCY... the Army announces the following committee meeting: Name of Committee: Army Education Advisory... , (757) 501-5810, or to the following address: Army Education Advisory Committee, Designated Federal...

  16. 75 FR 9887 - Advanced Scientific Computing Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ... DEPARTMENT OF ENERGY Advanced Scientific Computing Advisory Committee AGENCY: Department of Energy... Advanced Scientific Computing Advisory Committee (ASCAC). Federal Advisory Committee Act (Pub. L. 92-463... INFORMATION CONTACT: Melea Baker, Office of Advanced Scientific Computing Research; SC-21/Germantown Building...

  17. 76 FR 9765 - Advanced Scientific Computing Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-22

    ... DEPARTMENT OF ENERGY Advanced Scientific Computing Advisory Committee AGENCY: Office of Science... Advanced Scientific Computing Advisory Committee (ASCAC). The Federal Advisory Committee Act (Pub. L. 92... INFORMATION CONTACT: Melea Baker, Office of Advanced Scientific Computing Research, SC-21/Germantown Building...

  18. 76 FR 41559 - Debt Management Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-14

    ... DEPARTMENT OF THE TREASURY Debt Management Advisory Committee Meeting Notice is hereby given... management advisory committee: Treasury Borrowing Advisory Committee of The Securities Industry and Financial... decisions on major financing operations. Historically, this advice has been offered by debt management...

  19. 78 FR 19277 - Navigation Safety Advisory Council; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ... Safety Advisory Council; Meeting AGENCY: United States Coast Guard, DHS. ACTION: Notice of Federal Advisory Committee meeting: correction. SUMMARY: The Navigation Safety Advisory Council (NAVSAC) will meet..., groundings; Inland and International Rules of the Road; navigation regulations and equipment; routing...

  20. 76 FR 20336 - Defense Audit Advisory Committee (DAAC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ... DEPARTMENT OF DEFENSE Office of the Secretary Defense Audit Advisory Committee (DAAC) AGENCY... following Federal advisory committee meeting of the Defense Audit Advisory Committee will be held. DATES... management to include financial reporting processes, systems of internal controls, audit processes, and...

  1. 75 FR 18824 - Federal Advisory Committee; U.S. Strategic Command Strategic Advisory Group; Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; U.S. Strategic Command... 102-3.150, the Department of Defense announces that the U.S. Strategic Command Strategic Advisory... Commander, U.S. Strategic Command, during the development of the Nation's strategic war plans. Agenda Topics...

  2. 76 FR 40726 - Notification of Public Teleconferences of the Science Advisory Board Radiation Advisory Committee...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-11

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9435-3] Notification of Public Teleconferences of the Science... Protection Agency (EPA), Science Advisory Board Staff Office. ACTION: Notice. SUMMARY: The EPA Science... information concerning the EPA Science Advisory Board can be found at the EPA SAB Web site at http// www.epa...

  3. Targeting cholesterol synthesis increases chemoimmuno-sensitivity in chronic lymphocytic leukemia cells

    PubMed Central

    2014-01-01

    Background Cholesterol plays an important role in cancer development, drug resistance and chemoimmuno-sensitivity. Statins, cholesterol lowering drugs, can induce apoptosis, but also negatively interfere with CD-20 and rituximab-mediated activity. Our goal is to identify the alternative targets that could reduce cholesterol levels but do not interfere with CD-20 in chemo immunotherapy of chronic lymphocytic leukemia (CLL). Methods MEC-2 cells, a CLL cell line, and the peripheral blood mononuclear cells (PBMCs) from CLL patients were treated with cholesterol lowering agents, and analyzed the effect of these agents on cholesterol levels, CD-20 expression and distribution, and cell viability in the presence or absence of fludarabine, rituximab or their combinations. Results We found that MEC-2 cells treated with cholesterol lowering agents (BIBB-515, YM-53601 or TAK-475) reduced 20% of total cellular cholesterol levels, but also significantly promoted CD-20 surface expression. Furthermore, treatment of cells with fludarabine, rituximab or their combinations in the presence of BIBB-515, YM-53601 or TAK-475 enhanced MEC-2 cell chemoimmuno-sensitivity measured by cell viability. More importantly, these cholesterol lowering agents also significantly enhanced chemoimmuno-sensitivity of the PBMCs from CLL patients. Conclusion Our data demonstrate that BIBB-515, YM53601 and TAK-475 render chemoimmuno-therapy resistant MEC-2 cells sensitive to chemoimmuno-therapy and enhance CLL cell chemoimmuno-sensitivity without CD-20 epitope presentation or its downstream signaling. These results provide a novel strategy which could be applied to CLL treatment. PMID:25401046

  4. 75 FR 80039 - U.S. Travel and Tourism Advisory Board: Meeting of the U.S. Travel and Tourism Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-21

    ... DEPARTMENT OF COMMERCE International Trade Administration U.S. Travel and Tourism Advisory Board: Meeting of the U.S. Travel and Tourism Advisory Board AGENCY: International Trade Administration, U.S... agenda for an open meeting of the U.S. Travel and Tourism Advisory Board (Board). The agenda may change...

  5. 76 FR 53666 - U.S. Travel and Tourism Advisory Board: Meeting of the U.S. Travel and Tourism Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-29

    ... DEPARTMENT OF COMMERCE International Trade Administration U.S. Travel and Tourism Advisory Board: Meeting of the U.S. Travel and Tourism Advisory Board AGENCY: International Trade Administration, U.S... agenda for an open meeting of the U.S. Travel and Tourism Advisory Board (Board). The agenda may change...

  6. 76 FR 21703 - U.S. Travel and Tourism Advisory Board: Meeting of the U.S. Travel and Tourism Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-18

    ... DEPARTMENT OF COMMERCE International Trade Administration U.S. Travel and Tourism Advisory Board: Meeting of the U.S. Travel and Tourism Advisory Board AGENCY: International Trade Administration, U.S... agenda for an open meeting of the U.S. Travel and Tourism Advisory Board (Board). The agenda may change...

  7. 77 FR 29705 - Dodd-Frank Investor Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-18

    ... Investor Advisory Committee AGENCY: Securities and Exchange Commission. ACTION: Notice of First Meeting of Securities and Exchange Commission Dodd-Frank Investor Advisory Committee. SUMMARY: The Securities and Exchange Commission Investor Advisory Committee, established pursuant to Section 911 of the Dodd-Frank Wall...

  8. 77 FR 70807 - Advisory Board for Exceptional Children

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-27

    ... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Advisory Board for Exceptional Children AGENCY... (BIE) is announcing that the Advisory Board for Exceptional Children (Advisory Board) will hold its... with Disabilities Education Act of 2004 (IDEA) for Indian children with disabilities. DATES: The...

  9. 77 FR 47873 - Advisory Board for Exceptional Children

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-10

    ... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Advisory Board for Exceptional Children AGENCY... (BIE) is announcing that the Advisory Board for Exceptional Children (Advisory Board) will hold its... with Disabilities Education Act of 2004 (IDEA) for Indian children with disabilities. DATES: The...

  10. 76 FR 40929 - Advisory Board for Exceptional Children

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-12

    ... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Advisory Board for Exceptional Children AGENCY... (BIE) is announcing that the Advisory Board for Exceptional Children (Advisory Board) will hold its... with Disabilities Education Act of 2004 (IDEA) for Indian children with disabilities. DATES: The...

  11. 75 FR 50780 - Advisory Board for Exceptional Children

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-17

    ... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Advisory Board for Exceptional Children AGENCY... (BIE) is announcing that the Advisory Board for Exceptional Children (Advisory Board) will hold its... with Disabilities Education Act of 2004 (IDEA) for Indian children with disabilities. DATES: The...

  12. 76 FR 40714 - Fusion Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-11

    ... DEPARTMENT OF ENERGY Fusion Energy Sciences Advisory Committee AGENCY: Department of Energy... Energy Sciences Advisory Committee. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770... Fusion Energy Sciences; U.S. Department of Energy; 1000 Independence Avenue, SW., Washington, DC 20585...

  13. 78 FR 65980 - State Energy Advisory Board (STEAB)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... DEPARTMENT OF ENERGY State Energy Advisory Board (STEAB) AGENCY: Department of Energy, Office of Energy Efficiency and Renewable Energy. ACTION: Notice of open teleconference. SUMMARY: This notice announces a teleconference call of the State Energy Advisory Board (STEAB). The Federal Advisory Committee...

  14. 75 FR 6369 - Basic Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Department of Energy, Office... Energy Sciences Advisory Committee (BESAC). Federal Advisory Committee Act (Pub. L. 92- 463, 86 Stat. 770...: Katie Perine; Office of Basic Energy Sciences; U.S. Department of Energy; Germantown Building...

  15. 77 FR 5246 - Basic Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-02

    ... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Office of Science... of the Basic Energy Sciences Advisory Committee (BESAC). The Federal Advisory Committee Act (Pub. L... FURTHER INFORMATION CONTACT: Katie Perine; Office of Basic Energy Sciences; U.S. Department of Energy...

  16. 78 FR 15937 - Fusion Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-13

    ... DEPARTMENT OF ENERGY Fusion Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Fusion Energy Sciences Advisory Committee. The Federal Advisory Committee Act requires that public notice of...

  17. 78 FR 2259 - Fusion Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-10

    ... DEPARTMENT OF ENERGY Fusion Energy Sciences Advisory Committee AGENCY: Office of Science... Energy Sciences Advisory Committee. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770... Energy Sciences; U.S. Department of Energy; 1000 Independence Avenue SW.; Washington, DC 20585-1290...

  18. 77 FR 485 - Fusion Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-05

    ... DEPARTMENT OF ENERGY Fusion Energy Sciences Advisory Committee AGENCY: Office of Science... Energy Sciences Advisory Committee (FESAC). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat... Sciences; U.S. Department of Energy; 1000 Independence Avenue SW., Washington, DC 20585-1290; Telephone...

  19. 77 FR 34352 - Meeting of Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ... COMMODITY FUTURES TRADING COMMISSION Meeting of Technology Advisory Committee AGENCY: Commodity... 20, 2012, the CFTC's Technology Advisory Committee (``TAC'') will hold a public meeting at the CFTC's... of the Secretary. Please use the title ``Technology Advisory Committee'' in any written statement you...

  20. OCLC and Its Advisory Committees.

    ERIC Educational Resources Information Center

    Baker, Shirley K.

    1998-01-01

    Describes the Online Computer Library Center (OCLC) advisory committees in terms of research, public, college and university, and special libraries. All four of the type-of-library advisory groups work to shape OCLC policies and programs, according to the particular needs of each group. OCLC's financial and programmatic success depends upon…

  1. 75 FR 53694 - Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-01

    ... FEDERAL COMMUNICATIONS COMMISSION Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital Age AGENCY: Federal Communications Commission. ACTION: Notice of... Communications in the Digital Age (``Diversity Committee'') will hold a meeting on Tuesday, September 21, 2010 at...

  2. 78 FR 11142 - The National Advisory Council on Innovation and Entrepreneurship Meeting of the National Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-15

    ... Innovation and Entrepreneurship Meeting of the National Advisory Council on Innovation and Entrepreneurship... National Advisory Council on Innovation and Entrepreneurship (NACIE) has cancelled its open meeting... INFORMATION CONTACT: Nish Acharya, Office of Innovation and Entrepreneurship, Room 70007R, 1401 Constitution...

  3. 76 FR 41195 - Medbow-Routt Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-13

    ... DEPARTMENT OF AGRICULTURE Forest Service Medbow-Routt Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The MedBow-Routt Resource Advisory Committee will meet... Community Self-Determination Act (Pub. L. 110- 343) and in compliance with the Federal Advisory Committee...

  4. 16 CFR 16.4 - Advisory Committee Management Officer.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Advisory Committee Management Officer. 16.4 Section 16.4 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.4 Advisory Committee Management Officer. (a) The Commission shall...

  5. 16 CFR 1018.5 - Advisory Committee Management Officer.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Advisory Committee Management Officer. 1018.5 Section 1018.5 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ADVISORY COMMITTEE MANAGEMENT General Provisions § 1018.5 Advisory Committee Management Officer. The Chairman shall designate an...

  6. 16 CFR 1018.5 - Advisory Committee Management Officer.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Advisory Committee Management Officer. 1018.5 Section 1018.5 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ADVISORY COMMITTEE MANAGEMENT General Provisions § 1018.5 Advisory Committee Management Officer. The Chairman shall designate an...

  7. 16 CFR 1018.5 - Advisory Committee Management Officer.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Advisory Committee Management Officer. 1018.5 Section 1018.5 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ADVISORY COMMITTEE MANAGEMENT General Provisions § 1018.5 Advisory Committee Management Officer. The Chairman shall designate an...

  8. 16 CFR 16.4 - Advisory Committee Management Officer.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Advisory Committee Management Officer. 16.4 Section 16.4 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.4 Advisory Committee Management Officer. (a) The Commission shall...

  9. 16 CFR 16.4 - Advisory Committee Management Officer.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Advisory Committee Management Officer. 16.4 Section 16.4 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.4 Advisory Committee Management Officer. (a) The Commission shall...

  10. 16 CFR 16.4 - Advisory Committee Management Officer.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Advisory Committee Management Officer. 16.4 Section 16.4 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.4 Advisory Committee Management Officer. (a) The Commission shall...

  11. 16 CFR 1018.62 - Non-statutory advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Non-statutory advisory committees. 1018.62 Section 1018.62 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ADVISORY COMMITTEE MANAGEMENT Termination and Renewal § 1018.62 Non-statutory advisory committees. (a) Each non-statutory...

  12. 16 CFR 1018.5 - Advisory Committee Management Officer.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Advisory Committee Management Officer. 1018.5 Section 1018.5 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ADVISORY COMMITTEE MANAGEMENT General Provisions § 1018.5 Advisory Committee Management Officer. The Chairman shall designate an...

  13. 16 CFR 16.4 - Advisory Committee Management Officer.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Advisory Committee Management Officer. 16.4 Section 16.4 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.4 Advisory Committee Management Officer. (a) The Commission shall...

  14. 77 FR 39690 - State Energy Advisory Board (STEAB)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ... DEPARTMENT OF ENERGY State Energy Advisory Board (STEAB) AGENCY: Energy Efficiency and Renewable... teleconference call of the State Energy Advisory Board (STEAB). The Federal Advisory Committee Act (Pub. L. 92... Energy, Office of Energy Efficiency and Renewable Energy, 1000 Independence Ave. SW., Washington, DC...

  15. 75 FR 2159 - Scientific Earthquake Studies Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-14

    ... DEPARTMENT OF THE INTERIOR U.S. Geological Survey Scientific Earthquake Studies Advisory Committee... Scientific Earthquake Studies Advisory Committee (SESAC) will hold its next meeting at the U.S. Geological.... Meetings of the Scientific Earthquake Studies Advisory Committee are open to the public. DATES: January 26...

  16. 76 FR 61113 - Scientific Earthquake Studies Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-03

    ... DEPARTMENT OF THE INTERIOR U.S. Geological Survey Scientific Earthquake Studies Advisory Committee...-503, the Scientific Earthquake Studies Advisory Committee (SESAC) will hold its next meeting at the.... Meetings of the Scientific Earthquake Studies Advisory Committee are open to the public. DATES: November 2...

  17. 77 FR 12323 - Scientific Earthquake Studies Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-29

    ... DEPARTMENT OF THE INTERIOR U.S. Geological Survey Scientific Earthquake Studies Advisory Committee...-503, the Scientific Earthquake Studies Advisory Committee (SESAC) will hold its next meeting at the.... Meetings of the Scientific Earthquake Studies Advisory Committee are open to the public. DATES: March 29...

  18. 78 FR 56696 - National Environmental Education Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-13

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9900-99-OA] National Environmental Education Advisory Council... Advisory Committee Act, EPA gives notice of a meeting of the National Environmental Education Advisory..., functions and policies of EPA under the National Environmental Education Act (the Act). The purpose of this...

  19. 29 CFR 1430.3 - Establishment of advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Establishment of advisory committees. 1430.3 Section 1430.3 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE FEDERAL MEDIATION AND CONCILIATION SERVICE ADVISORY COMMITTEES § 1430.3 Establishment of advisory committees. (a...

  20. 76 FR 17965 - Advisory Board for Exceptional Children

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-31

    ... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Advisory Board for Exceptional Children AGENCY... (BIE) is announcing that the Advisory Board for Exceptional Children (Advisory Board) will hold its... Individuals with Disabilities Education Act of 2004 (IDEA) for Indian children with disabilities. DATES: The...

  1. 75 FR 82410 - Advisory Board for Exceptional Children

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-30

    ... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Advisory Board for Exceptional Children AGENCY... (BIE) is announcing that the Advisory Board for Exceptional Children (Advisory Board) will hold its... Individuals with Disabilities Education Act of 2004 (IDEA) for Indian children with disabilities. DATES: The...

  2. 77 FR 16062 - Advisory Board for Exceptional Children

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-19

    ... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Advisory Board for Exceptional Children AGENCY... (BIE) is announcing that the Advisory Board for Exceptional Children (Advisory Board) will hold its... Individuals with Disabilities Education Act of 2004 (IDEA) for Indian children with disabilities. DATES: The...

  3. 77 FR 28897 - Advisory Board for Exceptional Children

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-16

    ... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Advisory Board for Exceptional Children AGENCY... (BIE) is announcing that the Advisory Board for Exceptional Children (Advisory Board) will hold its... Individuals with Disabilities Education Act of 2004 (IDEA) for Indian children with disabilities. DATES: The...

  4. 75 FR 53334 - Advisory Board for Exceptional Children

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-31

    ... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Advisory Board for Exceptional Children AGENCY: Bureau of Indian Affairs, Interior. ACTION: Notice of meeting; correction. SUMMARY: The Bureau of Indian... Advisory Board for Exceptional Children (Advisory Board) will hold its next meeting in Washington, DC. The...

  5. 76 FR 48147 - Basic Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-08

    ... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of renewal of the Basic Energy Sciences Advisory Committee. SUMMARY... that the Basic Energy Sciences Advisory Committee will be renewed for a two-year period beginning July...

  6. 78 FR 38696 - Basic Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-27

    ... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Department of Energy, Office... Energy Sciences Advisory Committee (BESAC). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat... INFORMATION CONTACT: Katie Perine; Office of Basic Energy Sciences; U.S. Department of Energy; Germantown...

  7. 78 FR 6088 - Basic Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-29

    ... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Office of Science... Energy Sciences Advisory Committee (BESAC). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat... INFORMATION CONTACT: Katie Perine, Office of Basic Energy Sciences, U.S. Department of Energy; SC-22...

  8. 75 FR 8685 - Fusion Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-25

    ... DEPARTMENT OF ENERGY Fusion Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Fusion Energy Sciences Advisory Committee. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770...

  9. 76 FR 41234 - Basic Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-13

    ... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Basic Energy Sciences Advisory Committee (BESAC). Federal Advisory Committee Act (Pub. L. 92- 463, 86 Stat. 770...

  10. 77 FR 41395 - Basic Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-13

    ... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Basic Energy Sciences Advisory Committee (BESAC). Federal Advisory Committee Act (Pub. L. 92- 463, 86 Stat. 770...

  11. 75 FR 41838 - Basic Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-19

    ... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of Open Meeting. SUMMARY: This notice announces a meeting of the Basic Energy Sciences Advisory Committee (BESAC). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat...

  12. 76 FR 8358 - Basic Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-14

    ... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Basic Energy Sciences Advisory Committee (BESAC). Federal Advisory Committee Act (Pub. L. 92- 463, 86 Stat. 770...

  13. Procedures for setting curve advisory speed.

    DOT National Transportation Integrated Search

    2009-08-01

    The procedures described in this handbook are intended to improve consistency in curve signing and driver compliance with the advisory speed. The handbook describes guidelines for determining when an advisory speed is needed, criteria for identifying...

  14. National Space Council Users' Advisory Group

    NASA Image and Video Library

    2018-06-19

    Users' Advisory Group member Faith Ozmen, CEO of the Sierra Nevada Corporation is seen durring the first meeting of the National Space Council Users' Advisory Group, Tuesday, June 19, 2018 at NASA Headquarters in Washington. The Users' Advisory Group will advise and inform the National Space Council on a broad range of aerospace topics, including the impacts of U.S. and international laws and regulations, national security space priorities, scientific and human space exploration priorities, and ways to bolster support. Photo Credit: (NASA/Joel Kowsky)

  15. 75 FR 20844 - Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ... FEDERAL COMMUNICATIONS COMMISSION Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital Age AGENCY: Federal Communications Commission. ACTION: Notice of... Communications in the Digital Age (``Diversity Committee'') will hold a meeting on Tuesday, June 15, 2010 at 2:00...

  16. 75 FR 25212 - Federal Advisory Committee; Advisory Panel on Department of Defense Capabilities for Support of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-07

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Advisory Panel on Department of Defense Capabilities for Support of Civil Authorities After Certain Incidents AGENCY: Office of the Assistant Secretary of Defense (Homeland Defense and Americas' Security Affairs), DoD. ACTION...

  17. 16 CFR 16.15 - Reports of advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Reports of advisory committees. 16.15 Section 16.15 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.15 Reports of advisory committees. (a) The Commission shall furnish, on...

  18. 29 CFR 1430.5 - Termination of advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Termination of advisory committees. 1430.5 Section 1430.5 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE FEDERAL MEDIATION AND CONCILIATION SERVICE ADVISORY COMMITTEES § 1430.5 Termination of advisory committees. (a) All...

  19. 78 FR 42105 - Advisory Board for Exceptional Children

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-15

    ....97C22214.001] Advisory Board for Exceptional Children AGENCY: Bureau of Indian Affairs, Interior. ACTION... for Exceptional Children (Advisory Board) will hold its next meeting in Albuquerque, New Mexico. The... (IDEA) for Indian children with disabilities. DATES: The Advisory Board will meet on Thursday, July 18...

  20. 75 FR 73166 - Art Advisory Panel-Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-29

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Art Advisory Panel--Closed Meeting AGENCY: Internal Revenue Service, Treasury. ACTION: Notice of Closed Meeting of Art Advisory Panel for Decorative Art. SUMMARY: A closed meeting of the Art Advisory Panel will be held in Washington, DC. DATES: The...

  1. 78 FR 25064 - State Energy Advisory Board (STEAB)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-29

    ... DEPARTMENT OF ENERGY Office of Energy Efficiency and Renewable Energy State Energy Advisory Board (STEAB) AGENCY: Office of Energy Efficiency and Renewable Energy, Department of Energy. ACTION: Notice of... Energy Advisory Board (STEAB). The Federal Advisory Committee Act (Pub. L. 92-463; 86 Stat.770) requires...

  2. 78 FR 53740 - State Energy Advisory Board; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-30

    ... DEPARTMENT OF ENERGY State Energy Advisory Board; Meeting AGENCY: Energy Efficiency and Renewable Energy, Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a live Board meeting of the State Energy Advisory Board (STEAB). The Federal Advisory Committee Act (Pub. L. 92- 463...

  3. 77 FR 19017 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-29

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... Energy Employees Occupational Illness Compensation Program [[Page 19018

  4. 76 FR 67715 - Science Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-02

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration Science Advisory Board... (NOAA), Department of Commerce (DOC). ACTION: Notice of open meeting. SUMMARY: The Science Advisory... on strategies for research, education, and application of science to operations and information...

  5. 75 FR 63450 - DOE/NSF High Energy Physics Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-15

    ... DEPARTMENT OF ENERGY DOE/NSF High Energy Physics Advisory Panel AGENCY: Department of Energy.../NSF High Energy Physics Advisory Panel (HEPAP). Federal Advisory Committee Act (Pub. L. 92-463, 86... 20852. FOR FURTHER INFORMATION CONTACT: John Kogut, Executive Secretary; High Energy Physics Advisory...

  6. 75 FR 66388 - Scientific Earthquake Studies Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-28

    ... Studies Advisory Committee AGENCY: U.S. Geological Survey. ACTION: Notice of Meeting. SUMMARY: Pursuant to Public Law 106-503, the Scientific Earthquake Studies Advisory Committee (SESAC) will hold its next... Studies Advisory Committee are open to the public, seating may be limited due to room capacity. DATES: The...

  7. 75 FR 23288 - Advisory Board for Exceptional Children

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-03

    ... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Advisory Board for Exceptional Children AGENCY... Exceptional Children (Advisory Board) will hold its next meeting in Old Town, Maine. The purpose of the... Indian children with disabilities. DATES: The Advisory Board will meet on Monday, May 17, 2010, from 8:30...

  8. 77 FR 22390 - Debt Management Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    ... DEPARTMENT OF THE TREASURY Debt Management Advisory Committee Meeting Notice is hereby given... Pennsylvania Avenue NW., Washington, DC, on May 1, 2012 at 11:30 a.m. of the following debt management advisory... advice has been offered by debt management advisory committees established by the several major segments...

  9. 28 CFR 1.11 - Advisory nature of regulations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Advisory nature of regulations. 1.11 Section 1.11 Judicial Administration DEPARTMENT OF JUSTICE EXECUTIVE CLEMENCY § 1.11 Advisory nature of regulations. The regulations contained in this part are advisory only and for the internal guidance of...

  10. 28 CFR 1.11 - Advisory nature of regulations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Advisory nature of regulations. 1.11 Section 1.11 Judicial Administration DEPARTMENT OF JUSTICE EXECUTIVE CLEMENCY § 1.11 Advisory nature of regulations. The regulations contained in this part are advisory only and for the internal guidance of...

  11. 28 CFR 1.11 - Advisory nature of regulations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Advisory nature of regulations. 1.11 Section 1.11 Judicial Administration DEPARTMENT OF JUSTICE EXECUTIVE CLEMENCY § 1.11 Advisory nature of regulations. The regulations contained in this part are advisory only and for the internal guidance of...

  12. 28 CFR 1.11 - Advisory nature of regulations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Advisory nature of regulations. 1.11 Section 1.11 Judicial Administration DEPARTMENT OF JUSTICE EXECUTIVE CLEMENCY § 1.11 Advisory nature of regulations. The regulations contained in this part are advisory only and for the internal guidance of...

  13. 28 CFR 1.11 - Advisory nature of regulations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Advisory nature of regulations. 1.11 Section 1.11 Judicial Administration DEPARTMENT OF JUSTICE EXECUTIVE CLEMENCY § 1.11 Advisory nature of regulations. The regulations contained in this part are advisory only and for the internal guidance of...

  14. 75 FR 4819 - Consumer Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-29

    ... FEDERAL COMMUNICATIONS COMMISSION [DA 10-121] Consumer Advisory Committee AGENCY: Federal... its Consumer Advisory Committee (``Committee''). The purpose of the Committee is to make recommendations to the Commission regarding consumer issues within the jurisdiction of the Commission and to...

  15. 75 FR 41863 - Consumer Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-19

    ... FEDERAL COMMUNICATIONS COMMISSION [DA 10-1262] Consumer Advisory Committee AGENCY: Federal... its Consumer Advisory Committee (``Committee''). The purpose of the Committee is to make recommendations to the Commission regarding consumer issues within the jurisdiction of the Commission and to...

  16. 75 FR 63830 - Consumer Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-18

    ... FEDERAL COMMUNICATIONS COMMISSION [DA 10-1937] Consumer Advisory Committee AGENCY: Federal... its Consumer Advisory Committee (``Committee''). The purpose of the Committee is to make recommendations to the Commission regarding consumer issues within the jurisdiction of the Commission and to...

  17. 75 FR 33305 - Consumer Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-11

    ... FEDERAL COMMUNICATIONS COMMISSION [DA 10-1032] Consumer Advisory Committee AGENCY: Federal... its Consumer Advisory Committee (``Committee''). The purpose of the Committee is to make recommendations to the Commission regarding consumer issues within the jurisdiction of the Commission and to...

  18. 78 FR 46330 - DOE/NSF High Energy Physics Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-31

    ... DEPARTMENT OF ENERGY DOE/NSF High Energy Physics Advisory Panel AGENCY: Office of Science... High Energy Physics Advisory Panel (HEPAP). Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat... CONTACT: John Kogut, Executive Secretary; High Energy Physics Advisory Panel; U.S. Department of Energy...

  19. 76 FR 19986 - DOE/NSF High Energy Physics Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-11

    ... DEPARTMENT OF ENERGY DOE/NSF High Energy Physics Advisory Panel AGENCY: Department of Energy.../NSF High Energy Physics Advisory Panel (HEPAP). The Federal Advisory Committee Act (Pub. L. 92-463, 86... FURTHER INFORMATION CONTACT: John Kogut, Executive Secretary; High Energy Physics Advisory Panel; U.S...

  20. 77 FR 64799 - DOE/NSF High Energy Physics Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ... DEPARTMENT OF ENERGY DOE/NSF High Energy Physics Advisory Panel AGENCY: Department of Energy... Physics Advisory Panel (HEPAP). Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires... Kogut, Executive Secretary; High Energy Physics Advisory Panel; U.S. Department of Energy; SC-25...

  1. 21 CFR 14.145 - Procedures of a color additive advisory committee.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Procedures of a color additive advisory committee... SERVICES GENERAL PUBLIC HEARING BEFORE A PUBLIC ADVISORY COMMITTEE Color Additive Advisory Committees § 14.145 Procedures of a color additive advisory committee. (a) A color additive advisory committee is...

  2. 21 CFR 14.142 - Functions of a color additive advisory committee.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Functions of a color additive advisory committee... SERVICES GENERAL PUBLIC HEARING BEFORE A PUBLIC ADVISORY COMMITTEE Color Additive Advisory Committees § 14.142 Functions of a color additive advisory committee. (a) A color additive advisory committee reviews...

  3. 77 FR 62541 - Investor Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    ... SECURITIES AND EXCHANGE COMMISSION [Release Nos. 33-9365; 34-68019; File No. 265-28] Investor Advisory Committee AGENCY: Securities and Exchange Commission. ACTION: Notice of Telephonic Meeting of Securities and Exchange Commission Investor Advisory Committee. SUMMARY: The Securities and Exchange...

  4. 77 FR 5801 - Consumer Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-06

    ... FEDERAL COMMUNICATIONS COMMISSION [DA 12-105] Consumer Advisory Committee AGENCY: Federal... agenda of its Consumer Advisory Committee (Committee). The purpose of the Committee is to make... the participation of all consumers in proceedings before the Commission. DATES: The next meeting of...

  5. 78 FR 15968 - National Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-13

    ... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Docket ID: FEMA-2007-0008] National Advisory Council AGENCY: Federal Emergency Management Agency, DHS. ACTION: Committee Management... Management Agency (FEMA) is requesting individuals who are interested in serving on the National Advisory...

  6. 77 FR 9953 - National Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-21

    ... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Docket ID FEMA-2007-0008] National Advisory Council AGENCY: Federal Emergency Management Agency, DHS. ACTION: Committee Management... Management Agency (FEMA) is requesting individuals who are interested in serving on the National Advisory...

  7. 78 FR 14299 - Notification of a Public Meeting of the Science Advisory Board Chemical Assessment Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-05

    ... Authorization Act (ERDDAA) codified at 42 U.S.C. 4365, to provide independent scientific and technical peer..., 2012 (76 FR 223 pp. 71561-62; 77 FR 168 pp. 52330-31, respectively). Information about the formation of.... Federal advisory committees and panels, including scientific advisory committees, provide independent...

  8. 21 CFR 14.147 - Membership of a color additive advisory committee.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Membership of a color additive advisory committee... SERVICES GENERAL PUBLIC HEARING BEFORE A PUBLIC ADVISORY COMMITTEE Color Additive Advisory Committees § 14.147 Membership of a color additive advisory committee. (a) The members of a color additive advisory...

  9. 22 CFR 214.31 - A.I.D. Advisory Committee Representative.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... MANAGEMENT Operation of Advisory Committees § 214.31 A.I.D. Advisory Committee Representative. (a) For each... with the Advisory Committee Management Officer and the General Counsel for decisions by the... Advisory Committee Management Officer. (5) Assuring that open meetings are accessible to the public; (6) As...

  10. 77 FR 4027 - DOE/NSF High Energy Physics Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-26

    ... DEPARTMENT OF ENERGY DOE/NSF High Energy Physics Advisory Panel AGENCY: Department of Energy.../NSF High Energy Physics Advisory Panel (HEPAP). The Federal Advisory Committee Act (Pub. L. 92-463, 86... Secretary; High Energy Physics Advisory Panel; U.S. Department of Energy; SC-25/ Germantown Building, 1000...

  11. 76 FR 8358 - DOE/NSF High Energy Physics Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-14

    ... DEPARTMENT OF ENERGY DOE/NSF High Energy Physics Advisory Panel AGENCY: Department of Energy.../NSF High Energy Physics Advisory Panel (HEPAP). Federal Advisory Committee Act (Pub. L. 92-463, 86... Secretary; High Energy Physics Advisory Panel; U.S. Department of Energy; SC-25/ Germantown Building, 1000...

  12. 75 FR 57463 - DOE/NSF High Energy Physics Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-21

    ... DEPARTMENT OF ENERGY DOE/NSF High Energy Physics Advisory Panel AGENCY: Department of Energy.../NSF High Energy Physics Advisory Panel (HEPAP). Federal Advisory Committee Act (Pub. L. 92-463, 86... Secretary; High Energy Physics Advisory Panel; U.S. Department of Energy; SC-25/ Germantown Building, 1000...

  13. 78 FR 69839 - DOE/NSF High Energy Physics Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-21

    ... DEPARTMENT OF ENERGY DOE/NSF High Energy Physics Advisory Panel AGENCY: Department of Energy.../NSF High Energy Physics Advisory Panel (HEPAP). The Federal Advisory Committee Act (Pub. L. 92-463, 86... CONTACT: John Kogut, Executive Secretary; High Energy Physics Advisory Panel; U.S. Department of Energy...

  14. 77 FR 33449 - DOE/NSF High Energy Physics Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-06

    ... DEPARTMENT OF ENERGY DOE/NSF High Energy Physics Advisory Panel AGENCY: Office of Science... High Energy Physics Advisory Panel (HEPAP). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat..., Executive Secretary; High Energy Physics Advisory Panel; U.S. Department of Energy; SC-25/ Germantown...

  15. 76 FR 41234 - DOE/NSF High Energy Physics Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-13

    ... DEPARTMENT OF ENERGY DOE/NSF High Energy Physics Advisory Panel AGENCY: Department of Energy.../NSF High Energy Physics Advisory Panel (HEPAP). The Federal Advisory Committee Act (Pub. L. 92-463, 86... Secretary; High Energy Physics Advisory Panel; U.S. Department of Energy; SC-25/ Germantown Building, 1000...

  16. 78 FR 12043 - DOE/NSF High Energy Physics Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-21

    ... DEPARTMENT OF ENERGY DOE/NSF High Energy Physics Advisory Panel AGENCY: Office of Science... High Energy Physics Advisory Panel (HEPAP). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat... INFORMATION CONTACT: John Kogut, Executive Secretary; High Energy Physics Advisory Panel; U.S. Department of...

  17. 78 FR 70623 - Pipeline Safety: Meeting of the Gas Pipeline Advisory Committee and the Liquid Pipeline Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-26

    ... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No. PHMSA-2009-0203] Pipeline Safety: Meeting of the Gas Pipeline Advisory Committee and the Liquid Pipeline Advisory Committee AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. [[Page...

  18. 29 CFR 102.136 - Establishment and utilization of advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 2 2010-07-01 2010-07-01 false Establishment and utilization of advisory committees. 102... REGULATIONS, SERIES 8 Advisory Committees § 102.136 Establishment and utilization of advisory committees. Advisory committees may from time to time be established or utilized by the agency in the interest of...

  19. 29 CFR 102.136 - Establishment and utilization of advisory committees.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 2 2011-07-01 2011-07-01 false Establishment and utilization of advisory committees. 102... REGULATIONS, SERIES 8 Advisory Committees § 102.136 Establishment and utilization of advisory committees. Advisory committees may from time to time be established or utilized by the agency in the interest of...

  20. 76 FR 21349 - Science Advisory Board Staff Office; Request for Nominations of Candidates to the EPA's Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... serve on the chartered SAB in the following disciplines: Social, behavioral and decision sciences... ENVIRONMENTAL PROTECTION AGENCY [FRL-9296-4] Science Advisory Board Staff Office; Request for... Committee (CASAC), the Science Advisory Board (SAB), or SAB Committees described in this notice...

  1. 77 FR 45329 - Sabine Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-31

    ... DEPARTMENT OF AGRICULTURE Forest Service Sabine Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Sabine Resource Advisory Committee will meet in [[Page 45330

  2. 77 FR 5258 - World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP STAC or Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-02

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP STAC or Advisory Committee), National Institute for Occupational Safety and Health (NIOSH) Notice of Cancellation: This notice was published in the Federal Register on December 29,...

  3. 77 FR 8877 - World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP STAC or Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-15

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP STAC or Advisory Committee), National Institute for Occupational Safety and Health (NIOSH) Correction This notice was published in the Federal Register on January 31, 2012, Volume 77,...

  4. The ADVANCE project : formal evaluation of the targeted deployment. Volume 2

    DOT National Transportation Integrated Search

    1997-01-01

    This document reports on the formal evaluation of the targeted (limited but highly focused) deployment of the Advanced Driver and Vehicle Advisory Navigation ConcEpt (ADVANCE), an in-vehicle advanced traveler information system designed to provide sh...

  5. 10 CFR 7.10 - The NRC Advisory Committee Management Officer.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false The NRC Advisory Committee Management Officer. 7.10 Section 7.10 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.10 The NRC Advisory Committee Management Officer. (a) The Chairman of the Commission or designee shall appoint an NRC Advisory Committee...

  6. 10 CFR 7.10 - The NRC Advisory Committee Management Officer.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false The NRC Advisory Committee Management Officer. 7.10 Section 7.10 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.10 The NRC Advisory Committee Management Officer. (a) The Chairman of the Commission or designee shall appoint an NRC Advisory Committee...

  7. 10 CFR 7.10 - The NRC Advisory Committee Management Officer.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false The NRC Advisory Committee Management Officer. 7.10 Section 7.10 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.10 The NRC Advisory Committee Management Officer. (a) The Chairman of the Commission or designee shall appoint an NRC Advisory Committee...

  8. 49 CFR 95.9 - Meetings; other than industry advisory committees.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Meetings; other than industry advisory committees... Meetings; other than industry advisory committees. (a) Meetings of an advisory committee, other than an industry advisory committee, may be held only at the call, or with the advance approval, of a full-time...

  9. 49 CFR 95.9 - Meetings; other than industry advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Meetings; other than industry advisory committees... Meetings; other than industry advisory committees. (a) Meetings of an advisory committee, other than an industry advisory committee, may be held only at the call, or with the advance approval, of a full-time...

  10. 49 CFR 95.9 - Meetings; other than industry advisory committees.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Meetings; other than industry advisory committees... Meetings; other than industry advisory committees. (a) Meetings of an advisory committee, other than an industry advisory committee, may be held only at the call, or with the advance approval, of a full-time...

  11. 10 CFR 7.10 - The NRC Advisory Committee Management Officer.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false The NRC Advisory Committee Management Officer. 7.10 Section 7.10 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.10 The NRC Advisory Committee Management Officer. (a) The Chairman of the Commission or designee shall appoint an NRC Advisory Committee...

  12. 10 CFR 7.10 - The NRC Advisory Committee Management Officer.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false The NRC Advisory Committee Management Officer. 7.10 Section 7.10 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.10 The NRC Advisory Committee Management Officer. (a) The Chairman of the Commission or designee shall appoint an NRC Advisory Committee...

  13. 78 FR 21211 - Continuance of Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-10

    ...: Section 1. Continuing the President's Advisory Council on Faith-Based and Neighborhood Partnerships. The President's Advisory Council on Faith-Based and Neighborhood Partnerships, as set forth under the provisions...

  14. 76 FR 45504 - Virginia Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-29

    ... Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Virginia Resource Advisory Committee will meet in Roanoke, Virginia. The committee is authorized under the Secure...

  15. 77 FR 74099 - Reestablishment of Advisory Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-12

    ..., Health Promotion, and Integrative and Public Health. The Advisory Group on Prevention, Health Promotion, and Integrative and Public Health (Advisory Group), as set forth under the provisions of Executive...

  16. 77 FR 55201 - Biological and Environmental Research Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-07

    ... DEPARTMENT OF ENERGY Biological and Environmental Research Advisory Committee AGENCY: Department... teleconference of the Biological and Environmental Research Advisory Committee (BERAC). The Federal Advisory... Energy, Office of Science, Office of Biological and Environmental Research, SC-23/Germantown Building...

  17. 78 FR 6087 - Biological and Environmental Research Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-29

    ... Biological and Environmental Research News from the Biological Systems Science and Climate and Environmental... DEPARTMENT OF ENERGY Biological and Environmental Research Advisory Committee AGENCY: Office of... the Biological and Environmental Research Advisory Committee (BERAC). The Federal Advisory Committee...

  18. 77 FR 55200 - Biological and Environmental Research Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-07

    ... News from the Biological Systems Science and Climate and Environmental Sciences Divisions Discussion of... DEPARTMENT OF ENERGY Biological and Environmental Research Advisory Committee AGENCY: Office of... the Biological and Environmental Research Advisory Committee (BERAC). The Federal Advisory Committee...

  19. 78 FR 12043 - Biological and Environmental Research Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-21

    ... DEPARTMENT OF ENERGY Biological and Environmental Research Advisory Committee AGENCY: Office of... teleconference of the Biological and Environmental Research Advisory Committee (BERAC). The Federal Advisory... of Science, Office of Biological and Environmental Research, SC-23/Germantown Building, 1000...

  20. 77 FR 28368 - Biological and Environmental Research Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-14

    ... DEPARTMENT OF ENERGY Biological and Environmental Research Advisory Committee AGENCY: Office of... the Biological and Environmental Research Advisory Committee (BERAC). The Federal Advisory Committee... Energy, Office of Science, Office of Biological and Environmental Research, SC-23/Germantown Building...

  1. Quantitative risk assessment of foods containing peanut advisory labeling.

    PubMed

    Remington, Benjamin C; Baumert, Joseph L; Marx, David B; Taylor, Steve L

    2013-12-01

    Foods with advisory labeling (i.e. "may contain") continue to be prevalent and the warning may be increasingly ignored by allergic consumers. We sought to determine the residual levels of peanut in various packaged foods bearing advisory labeling, compare similar data from 2005 and 2009, and determine any potential risk for peanut-allergic consumers. Of food products bearing advisory statements regarding peanut or products that had peanut listed as a minor ingredient, 8.6% and 37.5% contained detectable levels of peanut (>2.5 ppm whole peanut), respectively. Peanut-allergic individuals should be advised to avoid such products regardless of the wording of the advisory statement. Peanut was detected at similar rates and levels in products tested in both 2005 and 2009. Advisory labeled nutrition bars contained the highest levels of peanut and an additional market survey of 399 products was conducted. Probabilistic risk assessment showed the risk of a reaction to peanut-allergic consumers from advisory labeled nutrition bars was significant but brand-dependent. Peanut advisory labeling may be overused on some nutrition bars but prudently used on others. The probabilistic approach could provide the food industry with a quantitative method to assist with determining when advisory labeling is most appropriate. Copyright © 2013 Elsevier Ltd. All rights reserved.

  2. 75 FR 81277 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-27

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... under the Energy Employees Occupational Illness Compensation Program Act of 2000 to advise the President...

  3. 76 FR 16787 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-25

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... was established under the Energy Employees Occupational Illness Compensation Program Act of 2000 to...

  4. 78 FR 11650 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-19

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... established under the Energy Employees Occupational Illness Compensation Program Act of 2000 to advise the...

  5. 78 FR 732 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-04

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... established under the Energy Employees Occupational Illness Compensation Program Act of 2000 to advise the...

  6. 75 FR 57281 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-20

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... under the Energy Employees Occupational Illness Compensation Program Act of 2000 to advise the President...

  7. 75 FR 11186 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... the Energy Employees Occupational Illness Compensation Program Act of 2000 to advise the President on...

  8. 76 FR 61364 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-04

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... Energy Employees Occupational Illness Compensation Program Act of 2000 to advise the President on a...

  9. 78 FR 44954 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-25

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... established under the Energy Employees Occupational Illness Compensation Program Act of 2000 to advise the...

  10. 78 FR 21370 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-10

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... Energy Employees Occupational Illness Compensation Program Act of 2000 to advise the President on a...

  11. 76 FR 36925 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-23

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... under the Energy Employees Occupational Illness Compensation Program Act of 2000 to advise the President...

  12. 77 FR 62240 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-12

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... established under the Energy Employees Occupational Illness Compensation Program Act of 2000 to advise the...

  13. 78 FR 61348 - Electricity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-03

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee AGENCY: Department of Energy. ACTION: Notice of Cancellation of Open Meeting. SUMMARY: On September 11, 2013, in FR Doc. 2013-22119, on pages... October 2-3, 2013 of the Electricity Advisory Committee (78 FR 55692). This notice announces the...

  14. 78 FR 57174 - Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-17

    ... recommended for inclusion on future Joint Board examinations in actuarial mathematics, pension law and... Advisory Committee on Actuarial Examinations. DATES: The meeting will be held on October 18, 2013, from 8.... SUPPLEMENTARY INFORMATION: Notice is hereby given that the Advisory Committee on Actuarial Examinations will...

  15. 48 CFR 401.371 - AGAR Advisories.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false AGAR Advisories. 401.371 Section 401.371 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE GENERAL AGRICULTURE ACQUISITION REGULATION SYSTEM Agency Acquisition Regulations 401.371 AGAR Advisories. The SPE may issue AGAR...

  16. 75 FR 53685 - Biological and Environmental Research Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-01

    ... DEPARTMENT OF ENERGY Biological and Environmental Research Advisory Committee AGENCY: Department... meeting of the Biological and Environmental Research Advisory Committee (BERAC). The Federal Advisory.... Department of Energy, Office of Science, Office of Biological and Environmental Research, SC-23/Germantown...

  17. 78 FR 34088 - Biological and Environmental Research Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ... Report from the Office of Biological and Environmental Research News from the Biological Systems Science... DEPARTMENT OF ENERGY Biological and Environmental Research Advisory Committee AGENCY: Office of... the Biological and Environmental Research Advisory Committee (BERAC). The Federal Advisory Committee...

  18. 77 FR 4028 - Biological and Environmental Research Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-26

    ... Report from the Office of Biological and Environmental Research News from the Biological Systems Science... DEPARTMENT OF ENERGY Biological and Environmental Research Advisory Committee AGENCY: Department... meeting of the Biological and Environmental Research Advisory Committee (BERAC). The Federal Advisory...

  19. 75 FR 6651 - Biological and Environmental Research Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-10

    ... From the Office of Science Report From the Office of Biological and Environmental Research News From... DEPARTMENT OF ENERGY Biological and Environmental Research Advisory Committee AGENCY: Department... meeting of the Biological and Environmental Research Advisory Committee (BERAC). Federal Advisory...

  20. 75 FR 64720 - DOE/Advanced Scientific Computing Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-20

    ... DEPARTMENT OF ENERGY DOE/Advanced Scientific Computing Advisory Committee AGENCY: Department of... the Advanced Scientific Computing Advisory Committee (ASCAC). Federal Advisory Committee Act (Pub. L.... FOR FURTHER INFORMATION CONTACT: Melea Baker, Office of Advanced Scientific Computing Research; SC-21...

  1. 78 FR 68887 - Dodd-Frank Investor Advisory Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-15

    ... Investor Advisory Committee; Meeting AGENCY: Securities and Exchange Commission. ACTION: Notice of Meeting of Securities and Exchange Commission Dodd- Frank Investor Advisory Committee. SUMMARY: The Securities and Exchange Commission Investor Advisory Committee, established pursuant to Section 911 of the...

  2. 77 FR 45345 - DOE/Advanced Scientific Computing Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-31

    ... Recompetition results for Scientific Discovery through Advanced Computing (SciDAC) applications Co-design Public... DEPARTMENT OF ENERGY DOE/Advanced Scientific Computing Advisory Committee AGENCY: Office of... the Advanced Scientific Computing Advisory Committee (ASCAC). The Federal Advisory Committee Act (Pub...

  3. 76 FR 52642 - Notice of Advisory Committee Closed Meeting; U.S. Strategic Command Strategic Advisory Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-23

    ... DEPARTMENT OF DEFENSE Notice of Advisory Committee Closed Meeting; U.S. Strategic Command.... Strategic Command Strategic Advisory Group. DATES: November 1, 2011, from 8 a.m. to 5 p.m. and November 2..., intelligence, and policy-related issues to the Commander, U.S. Strategic Command, during the development of the...

  4. 76 FR 23787 - Ashley Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-28

    ... Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Ashley Resource Advisory Committee will meet in Vernal, Utah. The committee is meeting as authorized under the...

  5. Overlapping topics in advisory reports issued by five well-established European National Immunization Technical Advisory Groups from 2011 to 2014.

    PubMed

    Nijsten, Daniëlle; Houweling, Hans; Durupt, Antoine; Adjagba, Alex

    2016-12-07

    National Immunization Technical Advisory Groups (NITAGs) are facing increasingly complex vaccination issues together with a lack of human resources for evidence assessment and data analysis. One way to reduce these burdens could be to share some of the preparatory work across NITAGs. We conducted an inventory of all the advisory reports issued by five well-established European NITAGs from 2011 to 2014 to assess overlaps in issues and activities. A total of 104 advisory reports were retrieved. Advisory reports on the same issues were compared to identify overlapping activities and processes. Advisory reports issued by the five NITAGs showed little overlap in issues and processes. A first step towards efficient collaboration would be to establish an independent platform to provide insight into each NITAG's work and to facilitate the exchange of agendas, assessment frameworks and evidence. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. 77 FR 65539 - Meeting of Global Markets Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-29

    ... COMMODITY FUTURES TRADING COMMISSION Meeting of Global Markets Advisory Committee AGENCY... its Global Markets Advisory Committee (``GMAC''). DATES: The meeting will be held on November 7, 2012... title ``Global Markets Advisory Committee'' in any written statement you may submit. Any statements...

  7. 78 FR 31977 - NASA Applied Sciences Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-28

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 13-061] NASA Applied Sciences Advisory... Aeronautics and Space Administration (NASA) announces a meeting of the Applied Sciences Advisory Committee (ASAC). This Committee functions in an advisory capacity to the Director, Earth Science Division. The...

  8. 77 FR 45331 - Prince William Sound Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-31

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince William Sound Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince William Sound Resource Advisory... Prince William Sound Resource Advisory Committee (RAC) will be discussing and voting on proposals that...

  9. 76 FR 1130 - Prince William Sound Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-07

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince William Sound Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince William Sound Resource Advisory... conducted: The Prince William Sound Resource Advisory Committee (RAC) will be discussing and voting on...

  10. 75 FR 29781 - President's National Security Telecommunications Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-27

    ...] President's National Security Telecommunications Advisory Committee AGENCY: National Protection and Programs... Security Telecommunications Advisory Committee (NSTAC) will be meeting by teleconference; the meeting will... telecommunications policy. Notice of this meeting is given under the Federal Advisory Committee Act (FACA), Public...

  11. 76 FR 13182 - Science Advisory Board Staff Office; Notification of a Public Meeting of the Science Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-10

    ... results of fact-finding activities conducted as part of a study of science integration supporting EPA... ENVIRONMENTAL PROTECTION AGENCY [FRL-9278-1] Science Advisory Board Staff Office; Notification of a Public Meeting of the Science Advisory Board Committee on Science Integration for Decision Making...

  12. 78 FR 38347 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-26

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... Employees Occupational Illness Compensation Program Act of 2000 to advise the President on a variety of...

  13. 78 FR 28594 - Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-15

    ... draft competitiveness report, and Ex-Im Bank economic impact policy update. Public Participation: The... EXPORT-IMPORT BANK OF THE UNITED STATES Advisory Committee Meeting ACTION: Notice of Open Meeting of the Advisory Committee of the Export- Import Bank of the United States (Ex-Im Bank). Time and...

  14. 18 CFR 701.59 - Advisory committees.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true Advisory committees. 701.59 Section 701.59 Conservation of Power and Water Resources WATER RESOURCES COUNCIL COUNCIL ORGANIZATION Headquarters Organization § 701.59 Advisory committees. The Council may establish standing and ad...

  15. 18 CFR 701.59 - Advisory committees.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Advisory committees. 701.59 Section 701.59 Conservation of Power and Water Resources WATER RESOURCES COUNCIL COUNCIL ORGANIZATION Headquarters Organization § 701.59 Advisory committees. The Council may establish standing and ad...

  16. 18 CFR 701.59 - Advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Advisory committees. 701.59 Section 701.59 Conservation of Power and Water Resources WATER RESOURCES COUNCIL COUNCIL ORGANIZATION Headquarters Organization § 701.59 Advisory committees. The Council may establish standing and ad...

  17. 18 CFR 701.59 - Advisory committees.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Advisory committees. 701.59 Section 701.59 Conservation of Power and Water Resources WATER RESOURCES COUNCIL COUNCIL ORGANIZATION Headquarters Organization § 701.59 Advisory committees. The Council may establish standing and ad...

  18. 18 CFR 701.59 - Advisory committees.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false Advisory committees. 701.59 Section 701.59 Conservation of Power and Water Resources WATER RESOURCES COUNCIL COUNCIL ORGANIZATION Headquarters Organization § 701.59 Advisory committees. The Council may establish standing and ad...

  19. 75 FR 54386 - Southeast Oregon Resource Advisory Council; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-07

    ...] Southeast Oregon Resource Advisory Council; Meeting AGENCY: Bureau of Land Management, Interior. ACTION: Southeast Oregon Resource Advisory Council. SUMMARY: Pursuant to the Federal Land Policy and Management Act... (BLM) Southeast Oregon Resource Advisory Council (SEORAC) will meet as indicated below: DATES: The...

  20. 75 FR 39703 - Meeting; Southeast Oregon Resource Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-12

    ...] Meeting; Southeast Oregon Resource Advisory Council AGENCY: Bureau of Land Management, Interior. ACTION: Southeast Oregon Resource Advisory Council. SUMMARY: Pursuant to the Federal Land Policy and Management Act... (BLM) Southeast Oregon Resource Advisory Council (SEORAC) will meet as indicated below: DATES: The...

  1. 77 FR 15362 - Efficiency and Renewables Advisory Committee (ERAC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-15

    ... DEPARTMENT OF ENERGY Efficiency and Renewables Advisory Committee (ERAC) AGENCY: Office of Energy Efficiency and Renewable Energy, Department of Energy ACTION: Notice of open meeting. SUMMARY: This notice announces an open meeting of the Efficiency and Renewables Advisory Committee (ERAC). The Federal Advisory...

  2. 75 FR 32469 - Consumer Advisory Council; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-08

    ... FEDERAL RESERVE SYSTEM Consumer Advisory Council; Notice of Meeting The Consumer Advisory Council... responsibilities under various consumer financial services laws and on other matters on which the Board seeks its... by sending written statements to Jennifer Kerslake, Secretary of the Consumer Advisory Council...

  3. 75 FR 43518 - Advanced Scientific Computing Advisory Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-26

    ... DEPARTMENT OF ENERGY Advanced Scientific Computing Advisory Committee; Meeting AGENCY: Office of... Scientific Computing Advisory Committee (ASCAC). Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770...: Melea Baker, Office of Advanced Scientific Computing Research; SC-21/Germantown Building; U. S...

  4. 77 FR 37389 - Renewal of the Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-21

    ... COMMODITY FUTURES TRADING COMMISSION Renewal of the Technology Advisory Committee AGENCY... Commodity Futures Trading Commission has determined to renew the charter of its Technology Advisory... and identity that it is for the renewal of the Technology Advisory Committee. All comments must be...

  5. 78 FR 9883 - Lake Tahoe Basin Federal Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-12

    ... Lake Tahoe Basin Federal Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice; Solicitation of nominees to the Lake Tahoe Basin Federal Advisory Committee. SUMMARY: In accordance with the...) announces solicitation of nominees to fill vacancies on the Lake Tahoe Basin Federal Advisory Committee...

  6. 77 FR 51791 - DOE/NSF Nuclear Science Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-27

    ... DEPARTMENT OF ENERGY DOE/NSF Nuclear Science Advisory Committee AGENCY: Department of Energy.../NSF Nuclear Science Advisory Committee (NSAC). The Federal Advisory Committee Act (Pub. L. 92-463, 86... on scientific priorities within the field of basic nuclear science research. Tentative Agenda: Agenda...

  7. 75 FR 6651 - DOE/NSF Nuclear Science Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-10

    ... DEPARTMENT OF ENERGY DOE/NSF Nuclear Science Advisory Committee AGENCY: Department of Energy.../NSF Nuclear Science Advisory Committee (NSAC). Federal Advisory Committee Act (Pub. L. 92- 463, 86... on scientific priorities within the field of basic nuclear science research. Tentative Agenda: Agenda...

  8. 75 FR 16159 - President's National Security Telecommunications Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-31

    ...] President's National Security Telecommunications Advisory Committee AGENCY: National Communications System... Telecommunications Advisory Committee (NSTAC) will hold its annual meeting on May 6, 2010. The meeting will be open... preparedness telecommunications policy. Notice of this meeting is given under the Federal Advisory Committee...

  9. Study of the pH-sensitive mechanism of tumor-targeting liposomes.

    PubMed

    Fan, Yang; Chen, Cong; Huang, Yiheng; Zhang, Fang; Lin, Guimei

    2017-03-01

    Currently, the phosphatidylethanolamine-based, pH-sensitive, liposome drug-delivery system has been widely developed for efficient, targeted cancer therapy. However, the mechanism of pH sensitivity was unclear; it is a main obstacle in controlling the preparation of pH-sensitive liposomes (PSLs).Therefore, our research is aimed at clarifying the pH-response mechanism of the various molecules that compose liposomes. We chose the small pH-sensitive molecules oleic acid (OA), linoleic acid (LA) and cholesteryl hemisuccinate (CHEMS) and the fundamental lipids cholesterol and phosphatidylethanolamine (PE) as test molecules. The PSLs were prepared using the thin-film hydration method and characterized in detail at various pH values (pH 5.0, 6.0 and 7.4), including particle size, ζ-potential, drug encapsulation efficiency and drug loading. The surface structure was observed by transmission electron microscopy (TEM), and the electrical conductivity of the liposome dispersion was also tested. The calorimetric analysis was conducted by Nano-differential scanning calorimetry (Nano-DSC). The in vitro drug release profile showed that PSLs exhibit good pH sensitivity. At neutral pH, the particle size was approximately 150nm, and it dramatically increased at pH 5.0. The ζ-potential increased as the pH decreased. The Nano-DSC results showed that cholesterol and CHEMS can both increase the stability and phase transfer temperature of PSLs. Conductivity increased to a maximum at pH 5.0 and was rather low at pH 7.4. In conclusion, results show that the three kinds of liposomes have pH responsive release characteristics in acidic pH. The OA-PSLs have a pH sensitive point of 5. Since CHEMS has a cholesterol-like structure, it can stabilizes the phospholipid bilayer under neutral conditions as shown in the Nano-DSC data, and because it has a special steroidal rigid structure, it exhibits better pH response characteristics under acidic conditions. Copyright © 2016 Elsevier B.V. All

  10. 75 FR 26918 - Siuslaw Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-13

    ... Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Siuslaw Resource Advisory Committee will meet in Corvallis, OR. The purpose of the meeting is to Review RAC FY10...

  11. 75 FR 58383 - Science Advisory Board Staff Office Request for Nominations of Experts for the Review of Great...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-24

    ... Action Plan identifies outcome-oriented performance goals, objectives, measurable ecological targets, and.... In an effort to obtain nominations of diverse candidates, EPA encourages nominations of women and men...) skills working in committees, subcommittees and advisory panels; and, for the Panel as a whole, (f...

  12. 77 FR 11547 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-27

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention (CDC) Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety and Health (NIOSH) The meeting scheduled to convene on February 28-29, 2012 was published in the...

  13. 77 FR 70543 - Pipeline Safety: Meeting of the Gas Pipeline Advisory Committee and the Liquid Pipeline Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-26

    .... PHMSA-2009-0203] Pipeline Safety: Meeting of the Gas Pipeline Advisory Committee and the Liquid Pipeline..., and safety policies for natural gas pipelines and for hazardous liquid pipelines. Both committees were...: Notice of advisory committee meeting. SUMMARY: This notice announces a public meeting of the Gas Pipeline...

  14. 75 FR 27825 - Arts Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-18

    ... NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES National Endowment for the Arts Arts Advisory..., notice is hereby given that one meeting of the Arts Advisory Panel to the National Council on the Arts..., evaluation, and recommendations on financial assistance under the National Foundation on the Arts and the...

  15. 76 FR 50499 - Arts Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-15

    ... NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES National Endowment for the Arts Arts Advisory..., notice is hereby given that one meeting of the Arts Advisory Panel to the National Council on the Arts..., evaluation, and recommendations on financial assistance under the National Foundation on the Arts and the...

  16. 75 FR 39201 - MedBow-Routt Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-08

    ... DEPARTMENT OF AGRICULTURE Forest Service MedBow-Routt Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The MedBow-Routt Resource Advisory Committee will meet... and Community Self-Determination Act (Pub. L. 110-343) and in compliance with the Federal Advisory...

  17. 75 FR 52304 - MedBow-Routt Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-25

    ... DEPARTMENT OF AGRICULTURE Forest Service MedBow-Routt Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The MedBow-Routt Resource Advisory Committee will meet... Community Self-Determination Act (Pub. L. 110- 343) and in compliance with the Federal Advisory Committee...

  18. 76 FR 12016 - MedBow-Routt Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-04

    ... DEPARTMENT OF AGRICULTURE Forest Service MedBow-Routt Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The MedBow-Routt Resource Advisory Committee will meet... Community Self-Determination Act (Pub. L. 110- 343) and in compliance with the Federal Advisory Committee...

  19. 77 FR 8214 - Black Hills National Forest Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-14

    ... DEPARTMENT OF AGRICULTURE Forest Service Black Hills National Forest Advisory Board AGENCY: USDA Forest Service. ACTION: Notice of intent to re-establish the Black Hills National Forest Advisory Board...-establish the Black Hills National Forest Advisory Board (Board). The purpose is to obtain advice and...

  20. 78 FR 14351 - Invasive Species Advisory Committee; Meeting Cancellation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-05

    ... DEPARTMENT OF THE INTERIOR Office of the Secretary Invasive Species Advisory Committee; Meeting... meeting of the Invasive Species Advisory Committee (ISAC) scheduled for Thursday, March 7, 2013 and Friday... invasive species experts and stakeholders from across the nation. The purpose of the Advisory Committee is...

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