Development of Autonomous Aerobraking (Phase 1)

NASA Technical Reports Server (NTRS)

Murri, Daniel G.; Powell, Richard W.; Prince, Jill L.

2012-01-01

The NASA Engineering and Safety Center received a request from Mr. Daniel Murri (NASA Technical Fellow for Flight Mechanics) to develop an autonomous aerobraking capability. An initial evaluation for all phases of this assessment was approved to proceed at the NESC Review Board meeting. The purpose of phase 1 of this study was to provide an assessment of the feasibility of autonomous aerobraking. During this phase, atmospheric, aerodynamic, and thermal models for a representative spacecraft were developed for both the onboard algorithm known as Autonomous Aerobraking Development Software, and a ground-based "truth" simulation developed for testing purposes. The results of the phase 1 assessment are included in this report.

Aerobrake assembly with minimum Space Station accommodation

NASA Technical Reports Server (NTRS)

Katzberg, Steven J.; Butler, David H.; Doggett, William R.; Russell, James W.; Hurban, Theresa

1991-01-01

The minimum Space Station Freedom accommodations required for initial assembly, repair, and refurbishment of the Lunar aerobrake were investigated. Baseline Space Station Freedom support services were assumed, as well as reasonable earth-to-orbit possibilities. A set of three aerobrake configurations representative of the major themes in aerobraking were developed. Structural assembly concepts, along with on-orbit assembly and refurbishment scenarios were created. The scenarios were exercised to identify required Space Station Freedom accommodations. Finally, important areas for follow-on study were also identified.

Autonomous Aerobraking Development Software: Phase 2 Summary

NASA Technical Reports Server (NTRS)

Cianciolo, Alicia D.; Maddock, Robert W.; Prince, Jill L.; Bowes, Angela; Powell, Richard W.; White, Joseph P.; Tolson, Robert; O'Shaughnessy, Daniel; Carrelli, David

2013-01-01

NASA has used aerobraking at Mars and Venus to reduce the fuel required to deliver a spacecraft into a desired orbit compared to an all-propulsive solution. Although aerobraking reduces the propellant, it does so at the expense of mission duration, large staff, and DSN coverage. These factors make aerobraking a significant cost element in the mission design. By moving on-board the current ground-based tasks of ephemeris determination, atmospheric density estimation, and maneuver sizing and execution, a flight project would realize significant cost savings. The NASA Engineering and Safety Center (NESC) sponsored Phase 1 and 2 of the Autonomous Aerobraking Development Software (AADS) study, which demonstrated the initial feasibility of moving these current ground-based functions to the spacecraft. This paper highlights key state-of-the-art advancements made in the Phase 2 effort to verify that the AADS algorithms are accurate, robust and ready to be considered for application on future missions that utilize aerobraking. The advancements discussed herein include both model updates and simulation and benchmark testing. Rigorous testing using observed flight atmospheres, operational environments and statistical analysis characterized the AADS operability in a perturbed environment.

Mars Reconnaissance Orbiter: Aerobraking Science Analysis

NASA Astrophysics Data System (ADS)

Bougher, Stephen W.; Keating, G. M.

2006-09-01

The Mars Reconnaissance Orbiter (MRO) spacecraft was launched from the Kennedy Space Center in Florida on August 12, 2005, and arrived at Mars on March 10, 2006. Aerobraking in the martian thermosphere was conducted for nearly 5-months after arrival, enabling the desired MRO mapping orbit to be achieved. The MRO aerobraking phase began in early martian northern Spring (Ls = 36) and continued through early northern Summer (Ls 110), spanning approximately 500 orbits. The MRO periapsis latitude migrated slowly poleward/southward from 70ºS latitude upon aerobraking initiation, passed over the South pole (near Ls = 77), and moved rapidly northward to equatorial latitudes at aerobraking conclusion. Upper atmosphere sampling ( 100-200 km) was achieved on the dayside (LT 1900-2000) before polar crossing, and on the nightside (LT = 0200-0300) thereafter. These seasonal and latitude conditions are similar to a subset of those experienced by MGS during its post hiatus aerobraking Phase 2. Derived mass densities, scale heights, and estimated temperatures are the primary data products generated from each aeropass. The most important discovery of MRO aerobraking concerns the sampling of the thermosphere up to 200 km, far higher than previous MGS and Odyssey Accelerometers have achieved. This sampling contributes to the characterization of the Mars exobase region, which is required to predict and interpret atmospheric escape rates. In addition, thermospheric densities at a constant altitude were observed to decrease toward the southern (winter) pole, as expected from previous MGS experience. No winter polar warming was typically observed near the South pole. Thereafter, densities were measured to increase on the nightside as periapsis moved toward the equator. In general, thermospheric variability was observed to increase in the vicinity of the polar vortex boundary ( 70-80ºS), and decreased again inside the vortex (high southern latitudes). Finally, longitude wave features

Space Tug Aerobraking Study. Volume 2: Technical

NASA Technical Reports Server (NTRS)

Corso, C. J.; Eyer, C. L.

1972-01-01

The feasibility and practicality of employing an aerobraking trajectory for return of the reusable Space Tug from geosynchronous and other high energy missions was investigated. The aerobraking return trajectory modes from high orbits employ transfer ellipses which have low perigee altitudes wherein the earth's sensible atmosphere provides drag to reduce the Tug descent delta velocity requirements and thus decrease the required return trip propulsive energy. An aerobraked Space Tug, sized to the Space Shuttle payload capability and dimensional constraints, can accomplish 95 percent of the geosynchronous missions with a single Shuttle/Tug launch per mission. Aerodynamics, aerothermodynamics, trajectory, quidance and control, configuration concepts, materials, weights and performance parameters were identified. Sensitivities to trajectory uncertainties, atmospheric anomalies and re-entry environments were determined. New technology requirements and future studies required to further enhance the aerobraking potential were identified.

Aeroheating Thermal Analysis Methods for Aerobraking Mars Missions

NASA Technical Reports Server (NTRS)

Amundsen, Ruth M.; Dec, John A.; George, Benjamin E.

2002-01-01

Mars missions often employ aerobraking upon arrival at Mars as a low-mass method to gradually reduce the orbit period from a high-altitude, highly elliptical insertion orbit to the final science orbit. Two recent missions that made use of aerobraking were Mars Global Surveyor (MGS) and Mars Odyssey. Both spacecraft had solar arrays as the main aerobraking surface area. Aerobraking produces a high heat load on the solar arrays, which have a large surface area exposed to the airflow and relatively low mass. To accurately model the complex behavior during aerobraking, the thermal analysis must be tightly coupled to the flight mechanics, aerodynamics, and atmospheric modeling efforts being performed during operations. To properly represent the temperatures prior to and during the drag pass, the model must include the orbital solar and planetary heat fluxes. The correlation of the thermal model to flight data allows a validation of the modeling process, as well as information on what processes dominate the thermal behavior. This paper describes the thermal modeling method that was developed for this purpose, as well as correlation for two flight missions, and a discussion of improvements to the methodology.

Magellan aerobrake navigation

NASA Technical Reports Server (NTRS)

Giorgini, Jon; Wong, S. Kuen; You, Tung-Han; Chadbourne, Pam; Lim, Lily

1995-01-01

The Magellan spacecraft has been aerobraked into a 197 x 541 km near-circular orbit around Venus from which it is conducting a high-resolution gravity mapping mission. This was the first interplanetary aerobrake maneuver and involved flying the spacecraft through the upper reaches of the Venusian atmosphere 730 times over a 70 day period. Round-trip light-time varied from 9.57 to 18.83 minutes during this period. Navigation for this dynamic phase of the Magellan mission was planned and executed in the face of budget-driven down-sizing with all spacecraft safe modes disabled and a flight-team one-third the size of comparable interplanetary missions. Successful execution of this manuever using spacecraft hardware not designed to operate in a planetary atmosphere, demonstrated a practical cost-saving technique for both large and small future interplanetary missions.

Autonomous Aerobraking Development Software: Phase One Performance Analysis at Mars, Venus, and Titan

NASA Technical Reports Server (NTRS)

Maddock, Robert W.; Bowes, Angela; Powell, Richard W.; Prince, Jill L. H.; Cianciolo, Alicia Dwyer

2012-01-01

When entering orbit about a planet or moon with an appreciable atmosphere, instead of using only the propulsion system to insert the spacecraft into its desired orbit, aerodynamic drag can be used after the initial orbit insertion to further decelerate the spacecraft. Several past NASA missions have used this aerobraking technique to reduce the fuel required to deliver a spacecraft into a desired orbit. Aerobraking was first demonstrated at Venus with Magellan in 1993 and then was used to achieve the science orbit of three Mars orbiters: Mars Global Surveyor in 1997, Mars Odyssey in 2001, and Mars Reconnaissance Orbiter in 2006. Although aerobraking itself reduces the propellant required to reach a final low period orbit, it does so at the expense of additional mission time to accommodate the aerobraking operations phase (typically 3-6 months), a large mission operations staff, and significant Deep Space Network (DSN) coverage. By automating ground based tasks and analyses associated with aerobraking and moving these onboard the spacecraft, a flight project could save millions of dollars in operations staffing and DSN costs (Ref. 1).

Analysis and sizing of Mars aerobrake structure

NASA Technical Reports Server (NTRS)

Raju, I. S.; Craft, W. J.

1993-01-01

A cone-sphere aeroshell structure for aerobraking into Martian atmosphere is studied. Using this structural configuration, a space frame load-bearing structure is proposed. To generate this structure efficiently and to perform a variety of studies of several configurations, a mesh generator that utilizes only a few configurational parameters is developed. A finite element analysis program that analyzes space frame structures was developed. A sizing algorithm that arrives at a minimum mass configuration was developed and integrated into the finite element analysis program. A typical 135-ft-diam aerobrake configuration was analyzed and sized. The minimum mass obtained in this study using high modulus graphite/epoxy composite material members is compared with the masses obtained from two other aerobrake structures using lightweight erectable tetrahedral truss and part-spherical truss configurations. Excellent agreement for the minimum mass was obtained with the three different aerobrake structures. Also, the minimum mass using the present structure was obtained when the supports were not at the base but at about 75 percent of the base diameter.

How 'HITEN's' aerobraking experiments were carried out

NASA Astrophysics Data System (ADS)

Kawaguchi, Jun'ichiro; Abe, Takashi; Uesugi, Kuninori

The ISAS (Institute of Space and Astronautical Science) 'HITEN' spacecraft was launched in January of 1990 from Kagoshima Space Center. The major mission was to demonstrate the so-called Double Lunar Swing-by Orbit as a precursor of GEOTAIL that is one spacecraft among the ISTP (International Solar Terrestrial Physics Program) fleet and scheduled to be launched in July, 1992. It carried various kinds of engineering missions on board, among them aerobraking experiments. Aerobraking as well as aerocapture techniques have been of great concern in interplanetary explorations since they may save tremendous among of fuel and add to scientific payload. However, practical application has not been made yet due to lack of aerothermodynamic features as well as guidance and navigation strategies. HITEN was specifically designed so that it could demonstrate and exemplify these aspects. It carried an anti-thermal blanket atop and two heat flux sensors to measure thermal environment during aerobraking. This paper presents how this world's first cis-lunar aerobraking experiment was carried out and what was found through it. Both heat flux and acceleration data obtained were well accounted for.

Space tug aerobraking study. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

Corso, C. J.; Eyer, C. L.

1972-01-01

The feasibility and practicality of employing an aerobraking trajectory for return of the reusable space tug from geosynchronous orbit was investigated. The aerobraking return trajectory modes employ transfer ellipses from high orbits which have low perigee altitudes wherein the earth's sensible atmosphere provides drag to reduce the tug return delta velocity requirements and thus decrease the required return trip propulsive energy. Aerodynamics, aerothermodynamics, trajectories, guidance and control, configuration concepts, materials, weights and performance were considered. Sensitivities to trajectory uncertainties, atmospheric anomalies and reentry environments were determined. New technology requirements and future studies required to further enhance the aerobraking potential were identified.

Aerobraking strategies for the sample of comet coma earth return mission

NASA Astrophysics Data System (ADS)

Abe, Takashi; Kawaguchi, Jun'ichiro; Uesugi, Kuninori; Yen, Chen-Wan L.

The results of a study to the validate the applicability of the aerobraking concept to the SOCCER (sample of comet coma earth return) mission using a six-DOF computer simulation of the aerobraking process are presented. The SOCCER spacecraft and the aerobraking scenario and power supply problem are briefly described. Results are presented for the spin effect, payload exposure problem, and sun angle effect.

Aerobraking strategies for the sample of comet coma earth return mission

NASA Technical Reports Server (NTRS)

Abe, Takashi; Kawaguchi, Jun'ichiro; Uesugi, Kuninori; Yen, Chen-Wan L.

1990-01-01

The results of a study to the validate the applicability of the aerobraking concept to the SOCCER (sample of comet coma earth return) mission using a six-DOF computer simulation of the aerobraking process are presented. The SOCCER spacecraft and the aerobraking scenario and power supply problem are briefly described. Results are presented for the spin effect, payload exposure problem, and sun angle effect.

Mars Reconnaissance Orbiter Aerobraking Daily Operations and Collision Avoidance

NASA Technical Reports Server (NTRS)

Long, Stacia M.; You, Tung-Han; Halsell, C. Allen; Bhat, Ramachand S.; Demcak, Stuart W.; Graat, Eric J.; Higa, Earl S.; Highsmith, Dolan E.; Mottinger, Neil A.; Jah, Moriba K.

2007-01-01

The Mars Reconnaissance Orbiter reached Mars on March 10, 2006 and performed a Mars orbit insertion maneuver of 1 km/s to enter into a large elliptical orbit. Three weeks later, aerobraking operations began and lasted about five months. Aerobraking utilized the atmospheric drag to reduce the large elliptical orbit into a smaller, near circular orbit. At the time of MRO aerobraking, there were three other operational spacecraft orbiting Mars and the navigation team had to minimize the possibility of a collision. This paper describes the daily operations of the MRO navigation team during this time as well as the collision avoidance strategy development and implementation.

Mars Reconnaissance Orbiter: Aerobraking Science Discoveries using the Accelerometer

NASA Astrophysics Data System (ADS)

Keating, Gerald M.; Bougher, S. W.

2006-09-01

The Mars Reconnaissance Orbiter (MRO) spacecraft was launched from the Kennedy Space Center in Florida on August 12, 2005, and arrived at Mars on March 10, 2006. Aerobraking in the martian thermosphere was conducted for nearly 5-months after arrival, enabling the desired MRO mapping orbit to be achieved. The MRO aerobraking phase began in early martian northern Spring (Ls = 36) and continued through early northern Summer (Ls 110), spanning approximately 500 orbits. The MRO periapsis latitude migrated slowly poleward/southward from 70ºS latitude upon aerobraking initiation, passed over the South pole (near Ls = 77), and moved rapidly northward to equatorial latitudes at aerobraking conclusion. Upper atmosphere sampling ( 100-200 km) was achieved on the dayside (LT 1900-2000) before polar crossing, and on the nightside (LT = 0200-0300) thereafter. These seasonal and latitude conditions are similar to a subset of those experienced by MGS during its post hiatus aerobraking Phase 2. Derived mass densities, scale heights, and estimated temperatures are the primary data products generated from each aeropass. The most important discovery of MRO aerobraking concerns the sampling of the thermosphere up to 200 km, far higher than previous MGS and Odyssey Accelerometers have achieved. This sampling contributes to the characterization of the Mars exobase region, which is required to predict and interpret atmospheric escape rates. In addition, thermospheric densities at a constant altitude were observed to decrease toward the southern (winter) pole, as expected from previous MGS experience. No winter polar warming was typically observed near the South pole. Thereafter, densities were measured to increase on the nightside as periapsis moved toward the equator. In general, thermospheric variability was observed to increase in the vicinity of the polar vortex boundary ( 70-80ºS), and decreased again inside the vortex (high southern latitudes). Finally, longitude wave features

Minimum accommodation for aerobrake assembly, phase 2

NASA Technical Reports Server (NTRS)

Katzberg, Stephen J.; Haynes, Davy A.; Tutterow, Robin D.; Watson, Judith J.; Russell, James W.

1994-01-01

A multi-element study was done to assess the practicality of a Space Station Freedom-based aerobrake system for the Space Exploration Initiative. The study was organized into six parts related to structure, aerodynamics, robotics and assembly, thermal protection system, inspection, and verification, all tied together by an integration study. The integration activity managed the broad issues related to meeting mission requirements. This report is a summary of the issues addressed by the integration team.

Preliminary structural design of a lunar transfer vehicle aerobrake. M.S. Thesis

NASA Technical Reports Server (NTRS)

Bush, Lance B.

1992-01-01

An aerobrake concept for a Lunar transfer vehicle was weight optimized through the use of the Taguchi design method, structural finite element analyses and structural sizing routines. Six design parameters were chosen to represent the aerobrake structural configuration. The design parameters included honeycomb core thickness, diameter to depth ratio, shape, material, number of concentric ring frames, and number of radial frames. Each parameter was assigned three levels. The minimum weight aerobrake configuration resulting from the study was approx. half the weight of the average of all twenty seven experimental configurations. The parameters having the most significant impact on the aerobrake structural weight were identified.

Aerobraking Magellan

NASA Technical Reports Server (NTRS)

Lyons, Daniel T.; Sjogren, William; Johnson, William T. K.; Schmitt, Durwin; Mcronald, Angus

1992-01-01

While the Magellan spacecraft is currently in an elliptical orbit around Venus, its orbit may be circularized by means of an aerobraking maneuver during which a minor amount of aerodynamic drag is applied to 1000-2000 orbits. An evaluation is presently undertaken of the thermal-control and operational problems arising from such a maneuver, in virtue of its not having been considered among the design requirements of the spacecraft. Attention is given to atmospheric erosion and contamination problems to which the spacecraft surfaces could be exposed.

Applications of low lift to drag ratio aerobrakes using angle of attack variation for control

NASA Technical Reports Server (NTRS)

Mulqueen, J. A.

1991-01-01

Several applications of low lift to drag ratio aerobrakes are investigated which use angle of attack variation for control. The applications are: return from geosynchronous or lunar orbit to low Earth orbit; and planetary aerocapture at Earth and Mars. A number of aerobrake design considerations are reviewed. It was found that the flow impingement behind the aerobrake and the aerodynamic heating loads are the primary factors that control the sizing of an aerobrake. The heating loads and other loads, such as maximum acceleration, are determined by the vehicle ballistic coefficient, the atmosphere entry conditions, and the trajectory design. Several formulations for defining an optimum trajectory are reviewed, and the various performance indices that can be used are evaluated. The 'nearly grazing' optimal trajectory was found to provide the best compromise between the often conflicting goals of minimizing the vehicle propulsive requirements and minimizing vehicle loads. The relationship between vehicle and trajectory design is investigated further using the results of numerical simulations of trajectories for each aerobrake application. The data show the sensitivity of the trajectories to several vehicle parameters and atmospheric density variations. The results of the trajectory analysis show that low lift to drag ratio aerobrakes, which use angle of attack variation for control, can potentially be used for a wide range of aerobrake applications.

Thermal Modeling of the Mars Reconnaissance Orbiter's Solar Panel and Instruments during Aerobraking

NASA Technical Reports Server (NTRS)

Dec, John A.; Gasbarre, Joseph F.; Amundsen, Ruth M.

2007-01-01

The Mars Reconnaissance Orbiter (MRO) launched on August 12, 2005 and started aerobraking at Mars in March 2006. During the spacecraft s design phase, thermal models of the solar panels and instruments were developed to determine which components would be the most limiting thermally during aerobraking. Having determined the most limiting components, thermal limits in terms of heat rate were established. Advanced thermal modeling techniques were developed utilizing Thermal Desktop and Patran Thermal. Heat transfer coefficients were calculated using a Direct Simulation Monte Carlo technique. Analysis established that the solar panels were the most limiting components during the aerobraking phase of the mission.

Local Time Variation of Water Vapor on Mars using TES Aerobraking Spectra

NASA Astrophysics Data System (ADS)

AlShamsi, M. R.; AlJanaahi, A. A.; Smith, M. D.; Altunaiji, E. S.; Edwards, C. S.

2016-12-01

During the Mars Global Surveyor (MGS) aerobraking phase, the spacecraft was in a large elliptical orbit that enabled the Thermal Emission Spectrometer (TES) instrument to sample many local times of Mars. The observed TES aerobraking spectra during that phase cover the time range between Mars Year 23, Ls=180° and Mars Year 24, Ls=30°. These TES aerobraking spectra have never been analyzed to study local time variations on Mars. Through radiative transfer modeling of the spectra, surface and atmospheric temperature, dust and water ice optical depth, and water vapor were retrieved. Specifically, the water vapor retrievals during aerobraking have similar seasonal and latitudinal trends to those in other Mars years observed by TES. These retrievals show somewhat higher water vapor during the morning hours (09:00-12:00) than in the afternoon (12:00-17:00) during southern summer (Ls=270°-330°) and little variation as a function of local time for southern fall (Ls=0°-30°). These retrievals show water vapor has a positive correlation with surface pressure (or negative correlation with altitude) indicating that water vapor is mixed in the lowest 10-20 km.

Weight optimization of an aerobrake structural concept for a lunar transfer vehicle

NASA Technical Reports Server (NTRS)

Bush, Lance B.; Unal, Resit; Rowell, Lawrence F.; Rehder, John J.

1992-01-01

An aerobrake structural concept for a lunar transfer vehicle was weight optimized through the use of the Taguchi design method, finite element analyses, and element sizing routines. Six design parameters were chosen to represent the aerobrake structural configuration. The design parameters included honeycomb core thickness, diameter-depth ratio, shape, material, number of concentric ring frames, and number of radial frames. Each parameter was assigned three levels. The aerobrake structural configuration with the minimum weight was 44 percent less than the average weight of all the remaining satisfactory experimental configurations. In addition, the results of this study have served to bolster the advocacy of the Taguchi method for aerospace vehicle design. Both reduced analysis time and an optimized design demonstrated the applicability of the Taguchi method to aerospace vehicle design.

Mars Aerobraking Spacecraft State Estimation by Processing Inertial Measurement Unit Data

NASA Technical Reports Server (NTRS)

Jah, Moriba K.; Lisano, Michael E.,, II; Born, George H.; Axelrad, Penina

2006-01-01

Aerobraking is an efficient technique for orbit adjustment of planetary spacecraft, such as Magellan (Venus), Mars Global Surveyor, and Mars Odyssey. Determination of the vehicle state during the aerobraking phase has conventionally been performed using only radiometric tracking data prior to and following the atmospheric drag pass. This approach is sufficiently accurate and timely to meet current mission operational requirements; however, it is expensive in terms of ground support and leads to delayed results because ofthe need for post-drag pass data. This research presents a new approach to estimation of the vehicle state during the atmospheric pass that sequentially incorporates observations from an Inertial Measurement Unit (IMU) and models of the vehicle and environment. The approach, called Inertial Measurements for Aerobraking Navigation (IMAN), is shown to perform at a level comparable to the conventional methods in terms of navigation accuracy and superior to them in terms of availability of the results immediately after completion ofthe pass. Furthermore, the research shows that IMAN can be used to reliably predict subsequent periapsis times and locations over all aerobraking regimes. IMAN also yields accurate peak dynamic pressure and heating rates, critical for a successful corridor control strategy, comparable to navigation team reconstructed values. This research also provides the first instance of the utilization of the Unscented Kalman Filter for the purpose of estimating an actual spacecraft trajectory arc about another planet.

Mars aerobraking spacecraft state estimation by processing inertial measurement unit data

NASA Astrophysics Data System (ADS)

Jah, Moriba Kemessia

Aerobraking is an efficient technique for orbit adjustment of planetary spacecraft such as Magellan (Venus), Mars Global Surveyor, and Mars Odyssey. Determination of the vehicle state during the Aerobraking phase has conventionally been performed using only radiometric tracking data prior to and following the atmospheric drag pass. This approach is sufficiently accurate and timely to meet current mission operational requirements; however, it is expensive in terms of ground support and leads to delayed results because of the need for post drag pass data. This dissertation presents a new approach to estimation of the vehicle state during the atmospheric pass that sequentially incorporates observations from an Inertial Measurement Unit (IMU) and models of the vehicle and environment. The approach, called Inertial Measurements for Aerobraking Navigation (IMAN), is shown to perform at a level comparable to the conventional methods in terms of navigation accuracy and superior to them in terms of availability of the results immediately after completion of the pass. Furthermore, the research shows that IMAN can be used to reliably predict subsequent periapsis times and locations over all aerobraking regimes. IMAN also yields accurate peak dynamic pressure and heating rates, critical for a successful corridor control strategy, comparable to navigation team reconstructed values. This research also provides the first instance of the utilization of the Unscented Kalman Filter for the purpose of estimating an actual spacecraft trajectory arc about another planet.

Application of Accelerometer Data to Mars Odyssey Aerobraking and Atmospheric Modeling

NASA Technical Reports Server (NTRS)

Tolson, R. H.; Keating, G. M.; George, B. E.; Escalera, P. E.; Werner, M. R.; Dwyer, A. M.; Hanna, J. L.

2002-01-01

Aerobraking was an enabling technology for the Mars Odyssey mission even though it involved risk due primarily to the variability of the Mars upper atmosphere. Consequently, numerous analyses based on various data types were performed during operations to reduce these risk and among these data were measurements from spacecraft accelerometers. This paper reports on the use of accelerometer data for determining atmospheric density during Odyssey aerobraking operations. Acceleration was measured along three orthogonal axes, although only data from the component along the axis nominally into the flow was used during operations. For a one second count time, the RMS noise level varied from 0.07 to 0.5 mm/s2 permitting density recovery to between 0.15 and 1.1 kg per cu km or about 2% of the mean density at periapsis during aerobraking. Accelerometer data were analyzed in near real time to provide estimates of density at periapsis, maximum density, density scale height, latitudinal gradient, longitudinal wave variations and location of the polar vortex. Summaries are given of the aerobraking phase of the mission, the accelerometer data analysis methods and operational procedures, some applications to determining thermospheric properties, and some remaining issues on interpretation of the data. Pre-flight estimates of natural variability based on Mars Global Surveyor accelerometer measurements proved reliable in the mid-latitudes, but overestimated the variability inside the polar vortex.

Chemical and Solar Electric Propulsion Systems Analyses for Mars Sample Return Missions

NASA Technical Reports Server (NTRS)

Donahue, Benjamin B.; Green, Shaun E.; Coverstone, Victoria L.; Woo, Byoungsam

2004-01-01

Conceptual in-space transfer stages, including those utilizing solar electric propulsion, chemical propulsion, and chemical propulsion with aerobraking or aerocapture assist at Mars, were evaluated. Roundtrip Mars sample return mission vehicles were analyzed to determine how specific system technology selections influence payload delivery capability. Results show how specific engine, thruster, propellant, capture mode, trip time and launch vehicle technology choices would contribute to increasing payload or decreasing the size of the required launch vehicles. Heliocentric low-thrust trajectory analyses for Solar Electric Transfer were generated with the SEPTOP code.

Orbital Transfer Vehicle (space taxi) with aerobraking at Earth and Mars

NASA Technical Reports Server (NTRS)

1987-01-01

This report shall cover all major aspects of the design of an Aeroassisted Manned Transfer Vehicle (or TAXI) for use as part of advanced manned Mars missions based on a cycling ship concept. Along with the heliocentric orbiting Cycling Spacecraft, such a TAXI would be a primary component of a long-term transportation system for Mars exploration. The Aeroassisted Manned Transfer Vehicle (AMTV) design developed shall operate along transfer trajectories between Earth and a Cycling Spacecraft (designed by the University of Michigan) and Mars. All operations of the AMTV shall be done primarily within the sphere of influence of the two planets. Maximum delta-V's for the vehicle have been established near 9 km/sec, with transfer durations of about 3 days. Acceleration deltaV's will be accomplished using 3 SSME-based hydrogen-oxygen chemical rockets (l(sub sp) = 485 sec & Thrust greater than = 300,00 Ib(sub f)/engine) with a thrust vector directly opposite the aerobraking deceleration vector. The aerobraking deceleration portion of an AMTV mission would be accomplished in this design by a moderate L/D aeroshield of an ellipsoidally-blunt, raked-off, elliptic cone (EBROEC) shape. The reusable thermal protection material comprising the shield will consist of a flexible, multi-layer, ceramic fabric stretched over a lightweight, rigid, shape - defining truss structure. Behind this truss, other components, including the engine supports, would be attached and protected from heating during aerobraking passes. Among these other components would be 2 LOX tanks and 4 LH2 tanks (and their support frames) holding over 670,000 lbm of propellant necessary to impart the required delta-V to the 98,000 lbm burnout mass vehicle. A 20,000 lbm crew module with docking port (oriented parallel to the accel./decel. axis) will provide accommodations for 9 crew members (11 under extreme conditions) for durations up to seven days, thus allowing extra time for emergency situations. This AMTV will be

The Development and Evaluation of an Operational Aerobraking Strategy for the Mars 2001 Odyssey Orbiter

NASA Technical Reports Server (NTRS)

Tartabini, Paul V.; Munk, Michelle M.; Powell, Richard W.

2002-01-01

The Mars 2001 Odyssey Orbiter successfully completed the aerobraking phase of its mission on January 11, 2002. This paper discusses the support provided by NASA's Langley Research Center to the navigation team at the Jet Propulsion Laboratory in the planning and operational support of Mars Odyssey Aerobraking. Specifically, the development of a three-degree-of-freedom aerobraking trajectory simulation and its application to pre-flight planning activities as well as operations is described. The importance of running the simulation in a Monte Carlo fashion to capture the effects of mission and atmospheric uncertainties is demonstrated, and the utility of including predictive logic within the simulation that could mimic operational maneuver decision-making is shown. A description is also provided of how the simulation was adapted to support flight operations as both a validation and risk reduction tool and as a means of obtaining a statistical basis for maneuver strategy decisions. This latter application was the first use of Monte Carlo trajectory analysis in an aerobraking mission.

An Aerobraking Strategy for Determining Mars Upper Atmospheric Structure

NASA Astrophysics Data System (ADS)

Bougher, S. W.; Murphy, J. R.; Haberle, R. M.

1997-07-01

The Mars Global Surveyor (MGS) spacecraft will enter Mars orbit on Sept. 12, 1997, and thereafter undergo aerobraking for roughly 4-months. The final data-taking orbit to be achieved is sun-synchronous (2PM/2AM). An aerobraking strategy has been developed that not only will provide the walk-in capability needed to safely achieve the required Mars orbit, but also will provide a careful monitoring of the atmospheric structure. In particular, the linkage between the lower (0-100 km) and upper (100- 150 km) Mars atmospheres will be investigated. A suite of complementary measurements is planned that will probe the atmosphere over 0-150 km, including : (1) MGS Accelerometer density and inferred temperatures (100-150 km), (2) MGS Thermal Emission Spectrometer (TES) nadir (25-30 km) and limb (up to about 55 km) temperatures, (3) MGS Electron Reflectometer (ER) F1-peak heights (near 130 km), (4) ground-based microwave disk-averaged temperatures (0-70 km), and (5) Mars Pathfinder (MPF) surface meteorological data at 20 N latitude. These datasets acquired during the aerobraking phase will enable the current state of the atmosphere to be examined. Potential dust storm activity and its manifestations throughout the atmosphere can be monitored over Ls = 184 to 250. A corresponding library of coupled 3-D model simulations, based upon the NASA Ames Mars GCM and the NCAR Mars Thermospheric GCM (MTGCM), will be used to : (1) validate the current state of the Mars atmosphere, (2) investigate the various orbital, seasonal, LAT-LT-LON, and potential dust storm trends, and (3) predict the structure of the Mars atmosphere in the aerobraking corridor that is approaching in future MGS orbits. The in-situ accelerometer and ER data will eventually be used to construct a Mars empirical model covering 100-150 km. We will present a few selected GCM simulations to illustrate the expected atmospheric response to a dust storm event. In addition, we will discuss why these upper atmosphere datasets

The Next Generation of Mars-GRAM and Its Role in the Autonomous Aerobraking Development Plan

NASA Technical Reports Server (NTRS)

Justh, Hilary L.; Justus, Carl G.; Ramey, Holly S.

2011-01-01

The Mars Global Reference Atmospheric Model (Mars-GRAM) is an engineering-level atmospheric model widely used for diverse mission applications. Mars-GRAM 2010 is currently being used to develop the onboard atmospheric density estimator that is part of the Autonomous Aerobraking Development Plan. In previous versions, Mars-GRAM was less than realistic when used for sensitivity studies for Thermal Emission Spectrometer (TES) MapYear=0 and large optical depth values, such as tau=3. A comparison analysis has been completed between Mars-GRAM, TES and data from the Planetary Data System (PDS) resulting in updated coefficients for the functions relating density, latitude, and longitude of the sun. The adjustment factors are expressed as a function of height (z), Latitude (Lat) and areocentric solar longitude (Ls). The latest release of Mars-GRAM 2010 includes these adjustment factors that alter the in-put data from MGCM and MTGCM for the Mapping Year 0 (user-controlled dust) case. The greatest adjustment occurs at large optical depths such as tau greater than 1. The addition of the adjustment factors has led to better correspondence to TES Limb data from 0-60 km as well as better agreement with MGS, ODY and MRO data at approximately 90-135 km. Improved simulations utilizing Mars-GRAM 2010 are vital to developing the onboard atmospheric density estimator for the Autonomous Aerobraking Development Plan. Mars-GRAM 2010 was not the only planetary GRAM utilized during phase 1 of this plan; Titan-GRAM and Venus-GRAM were used to generate density data sets for Aerobraking Design Reference Missions. These data sets included altitude profiles (both vertical and along a trajectory), GRAM perturbations (tides, gravity waves, etc.) and provided density and scale height values for analysis by other Autonomous Aero-braking team members.

Probabilistic Thermal Analysis During Mars Reconnaissance Orbiter Aerobraking

NASA Technical Reports Server (NTRS)

Dec, John A.

2007-01-01

A method for performing a probabilistic thermal analysis during aerobraking has been developed. The analysis is performed on the Mars Reconnaissance Orbiter solar array during aerobraking. The methodology makes use of a response surface model derived from a more complex finite element thermal model of the solar array. The response surface is a quadratic equation which calculates the peak temperature for a given orbit drag pass at a specific location on the solar panel. Five different response surface equations are used, one of which predicts the overall maximum solar panel temperature, and the remaining four predict the temperatures of the solar panel thermal sensors. The variables used to define the response surface can be characterized as either environmental, material property, or modeling variables. Response surface variables are statistically varied in a Monte Carlo simulation. The Monte Carlo simulation produces mean temperatures and 3 sigma bounds as well as the probability of exceeding the designated flight allowable temperature for a given orbit. Response surface temperature predictions are compared with the Mars Reconnaissance Orbiter flight temperature data.

A comparison of two conformal mapping techniques applied to an aerobrake body

NASA Technical Reports Server (NTRS)

Hommel, Mark J.

1987-01-01

Conformal mapping is a classical technique which has been utilized for solving problems in aerodynamics and hydrodynamics. Conformal mapping has been successfully applied in the construction of grids around airfoils, engine inlets and other aircraft configurations. Conformal mapping techniques were applied to an aerobrake body having an axis of symmetry. Two different approaches were utilized: (1) Karman-Trefftz transformation; and (2) Point Wise Schwarz Christoffel transformation. In both cases, the aerobrake body was mapped onto a near circle, and a grid was generated in the mapped plane. The mapped body and grid were then mapped back into physical space and the properties of the associated grids were examined. Advantages and disadvantages of both approaches are discussed.

Lambert Reflectance Albedo And Temperature Mapping Of Thermal Emission Spectrometer Data During The Mars Global Surveyor Aerobraking Phase

NASA Astrophysics Data System (ADS)

Badri, K. M.; Alqasim, A.; Altunaiji, E. S.; Edwards, C. S.; Smith, M. D.

2017-12-01

The goal of this work is to create multiple sets of maps using Thermal Emission Spectrometer (TES) data that encompass the aerobraking phase of the Mars Global Surveyor mission. This work will serve as a proof of concept for the upcoming Emirates Mars Mission, where the Emirates Mars Infrared Spectrometer (EMRIS) will generate data acquired in a similar manner to that acquired by TES during aerobraking. To generate maps of these data on a global scale, python will be used in combination with the Spacecraft Planet Instrument Camera Matrix and Event (SPICE) toolkit to determine the geometry of the pixels on the planet surface. TES is an instrument within the Mars Global Surveyor (MGS) spacecraft. It is a Fourier transform infrared spectrometer developed to study the surface and atmosphere of Mars using thermal infrared emission spectroscopy. TES consists of six detectors arranged in a 2x3 array with a nominal spot size of 3 × 6 km when in its nominal mapping orbit. Over the southern hemisphere during aerobraking the footprint is significantly larger (10s of km) due to the elliptical nature of the orbit during this phase of the mission. TES aerobraking spectra were taken between Mars Year 23, Ls=180° and Mars Year 24, Ls=30°. Here we map TES footprints to the surface during MGS aerobraking, binned by solar longitude to observe differences on the surface in both temperature and Lambert albedo.

Thermal Analysis and Correlation of the Mars Odyssey Spacecraft's Solar Array During Aerobraking Operations

NASA Technical Reports Server (NTRS)

Dec, John A.; Gasbarre, Joseph F.; George, Benjamin E.

2002-01-01

The Mars Odyssey spacecraft made use of multipass aerobraking to gradually reduce its orbit period from a highly elliptical insertion orbit to its final science orbit. Aerobraking operations provided an opportunity to apply advanced thermal analysis techniques to predict the temperature of the spacecraft's solar array for each drag pass. Odyssey telemetry data was used to correlate the thermal model. The thermal analysis was tightly coupled to the flight mechanics, aerodynamics, and atmospheric modeling efforts being performed during operations. Specifically, the thermal analysis predictions required a calculation of the spacecraft's velocity relative to the atmosphere, a prediction of the atmospheric density, and a prediction of the heat transfer coefficients due to aerodynamic heating. Temperature correlations were performed by comparing predicted temperatures of the thermocouples to the actual thermocouple readings from the spacecraft. Time histories of the spacecraft relative velocity, atmospheric density, and heat transfer coefficients, calculated using flight accelerometer and quaternion data, were used to calculate the aerodynamic heating. During aerobraking operations, the correlations were used to continually update the thermal model, thus increasing confidence in the predictions. This paper describes the thermal analysis that was performed and presents the correlations to the flight data.

Aerobrake plasmadynamics - Macroscopic effects

NASA Technical Reports Server (NTRS)

Shebalin, John V.

1990-01-01

The flow around an aerobraking spacecraft (such as the Aeroassist Flight Experiment reentry vehicle) will contain a region of partially ionized gas, that is, a plasma. It is shown here by numerical simulation that macroscopic plasmadynamic effects (which are not included in standard aerothermodynamic simulations) will have a noticeable effect on the reentry flow field. In particular, there are thermoelectric phenomena which can have a major influence in flow dynamics at the front of an ionizing bowshock. These thermoelectric phenomena arise because of the presence of large density and temperature gradients at the front of a reentry bowshock, and they include strong local magnetic fields, electric currents, and ohmic heating. One important result is the dramatic increase in temperature (over the case where plasma effects are neglected) at a reentry shock front; the implication is that macroscopic plasmadynamic effects can no longer be neglected in simulations of hypersonic reentry flow fields.

ExoMars Trace Gas Orbiter provides atmospheric data during Aerobraking into its final orbit

NASA Astrophysics Data System (ADS)

Svedhem, Hakan; Vago, Jorge L.; Bruinsma, Sean; Müller-Wodarg, Ingo; ExoMars 2016 Team

2017-10-01

After the arrival of the Trace Gas Orbiter (TGO) at Mars on 19 October 2016 a number of initial orbit change manoeuvres were executed and the spacecraft was put in an orbit with a 24 hour period and 74 degrees inclination. The spacecraft and its four instruments were thoroughly checked out after arrival and a few measurements and images were taken in November 2016 and in Feb-March 2017. The solar occultation observations have however not yet been possible due to lack of the proper geometry.On 15 March a long period of aerobraking to reach the final 400km semi-circular frozen orbit (370x430km, with a fixed pericentre latitude). This orbit is optimised for the payload observations and for the communication relay with the ExoMars Rover, due to arrive in 2021.The aerobraking is proceeding well and the final orbit is expected to be reached in April 2018. A large data set is being acquired for the upper atmosphere of Mars, from the limit of the sensitivity of the accelerometer, down to lowest altitude of the aerobraking at about 105km. Initial analysis has shown a highly variable atmosphere with a slightly lower density then predicted by existing models. Until the time of the abstract writing no dust storms have been observed.The ExoMars programme is a joint activity by the European Space Agency(ESA) and ROSCOSMOS, Russia. ESA is providing the TGO spacecraft and Schiaparelli (EDM) and two of the TGO instruments and ROSCOSMOS is providing the Proton launcher and the other two TGO instruments. After the arrival of the ExoMars 2020 mission, consisting of a Rover and a Surface platform also launched by a Proton rocket, the TGO will handle the communication between the Earth and the Rover and Surface Platform through its (NASA provided) UHF communication system.

Heavily loaded joints for assembling aerobrake support trusses

NASA Technical Reports Server (NTRS)

Bandel, Hannskarl; Olsson, Nils; Levintov, Boris

1990-01-01

The major emphasis was to develop erectable joints for large aerobrake support trusses. The truss joints must be able to withstand the large forces experienced by the truss during the aero-pass, as well as be easily assembled and disassembled on orbit by astronauts or robots. Other important design considerations include; strength, stiffness, and allowable error in strut length. Six mechanical joint designs, as well as a seventh joint design, where a high strength epoxy is injected to make the connection rigid, are presented.

Aerobraking Maneuver (ABM) Report Generator

NASA Technical Reports Server (NTRS)

Fisher, Forrest; Gladden, Roy; Khanampornpan, Teerapat

2008-01-01

abmREPORT Version 3.1 is a Perl script that extracts vital summarization information from the Mars Reconnaissance Orbiter (MRO) aerobraking ABM build process. This information facilitates sequence reviews, and provides a high-level summarization of the sequence for mission management. The script extracts information from the ENV, SSF, FRF, SCMFmax, and OPTG files and burn magnitude configuration files and presents them in a single, easy-to-check report that provides the majority of the parameters necessary for cross check and verification during the sequence review process. This means that needed information, formerly spread across a number of different files and each in a different format, is all available in this one application. This program is built on the capabilities developed in dragReport and then the scripts evolved as the two tools continued to be developed in parallel.

Description and performance analysis of a generalized optimal algorithm for aerobraking guidance

NASA Technical Reports Server (NTRS)

Evans, Steven W.; Dukeman, Greg A.

1993-01-01

A practical real-time guidance algorithm has been developed for aerobraking vehicles which nearly minimizes the maximum heating rate, the maximum structural loads, and the post-aeropass delta V requirement for orbit insertion. The algorithm is general and reusable in the sense that a minimum of assumptions are made, thus greatly reducing the number of parameters that must be determined prior to a given mission. A particularly interesting feature is that in-plane guidance performance is tuned by adjusting one mission-dependent, the bank margin; similarly, the out-of-plane guidance performance is tuned by adjusting a plane controller time constant. Other features of the algorithm are simplicity, efficiency and ease of use. The trimmed vehicle with bank angle modulation as the method of trajectory control. Performance of this guidance algorithm is examined by its use in an aerobraking testbed program. The performance inquiry extends to a wide range of entry speeds covering a number of potential mission applications. Favorable results have been obtained with a minimum of development effort, and directions for improvement of performance are indicated.

TPS design for aerobraking at Earth and Mars

NASA Astrophysics Data System (ADS)

Williams, S. D.; Gietzel, M. M.; Rochelle, W. C.; Curry, D. M.

1991-08-01

An investigation was made to determine the feasibility of using an aerobrake system for manned and unmanned missions to Mars, and to Earth from Mars and lunar orbits. A preliminary thermal protection system (TPS) was examined for five unmanned small nose radius, straight bi-conic vehicles and a scaled up Aeroassist Flight Experiment (AFE) vehicle aerocapturing at Mars. Analyses were also conducted for the scaled up AFE and an unmanned Sample Return Cannister (SRC) returning from Mars and aerocapturing into Earth orbit. Also analyzed were three different classes of lunar transfer vehicles (LTV's): an expendable scaled up modified Apollo Command Module (CM), a raked cone (modified AFT), and three large nose radius domed cylinders. The LTV's would be used to transport personnel and supplies between Earth and the moon in order to establish a manned base on the lunar surface. The TPS for all vehicles analyzed is shown to have an advantage over an all-propulsive velocity reduction for orbit insertion. Results indicate that TPS weight penalties of less than 28 percent can be achieved using current material technology, and slightly less than the most favorable LTV using advanced material technology.

Mechanistic model for catalytic recombination during aerobraking maneuvers

NASA Technical Reports Server (NTRS)

Willey, Ronald J.

1989-01-01

Several mechanistic models are developed to predict recombination coefficients for use in heat shield design for reusable surface insulation (RSI) on aerobraking vehicles such as space shuttles. The models are applied over a temperature range of 300 to 1800 K and a stagnation pressure range of 0 to 3,000 Pa. A four parameter model in temperature was found to work best; however, several models (including those with atom concentrations at the surface) were also investigated. Mechanistic models developed with atom concentration terms may be applicable when sufficient data becomes available. The requirement is shown for recombination experiments in the 300 to 1000 K and 1500 to 1850 K temperature range, with deliberate concentration variations.

Robust control algorithms for Mars aerobraking

NASA Technical Reports Server (NTRS)

Shipley, Buford W., Jr.; Ward, Donald T.

1992-01-01

Four atmospheric guidance concepts have been adapted to control an interplanetary vehicle aerobraking in the Martian atmosphere. The first two offer improvements to the Analytic Predictor Corrector (APC) to increase its robustness to density variations. The second two are variations of a new Liapunov tracking exit phase algorithm, developed to guide the vehicle along a reference trajectory. These four new controllers are tested using a six degree of freedom computer simulation to evaluate their robustness. MARSGRAM is used to develop realistic atmospheres for the study. When square wave density pulses perturb the atmosphere all four controllers are successful. The algorithms are tested against atmospheres where the inbound and outbound density functions are different. Square wave density pulses are again used, but only for the outbound leg of the trajectory. Additionally, sine waves are used to perturb the density function. The new algorithms are found to be more robust than any previously tested and a Liapunov controller is selected as the most robust control algorithm overall examined.

Evidence for Recent Liquid Water on Mars: Seepage Sites in 'Aerobraking Crater' Revisited

NASA Technical Reports Server (NTRS)

2000-01-01

(A) [figure removed for brevity, see original site] (B) [figure removed for brevity, see original site] (C) (D) You will need 3D glasses to view this anaglyph

The first clue that there might be places on Mars where liquid groundwater seeps out onto the surface came from a picture taken by the Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) during the pre-mapping Orbit Insertion Phase of the mission. The picture, shown in (A)above, was taken at the end of December 1997 while the spacecraft was still in the midst of aerobraking maneuvers to put it into the circular orbit needed for the Mapping Phase of the project. The Aerobraking 1 image, AB1-07707, showed dark, v-shaped scars on the western wall of a 50 kilometer-(31 mile)-diameter impact crater in southern Noachis Terra at 65oS, 15oW (see B, above, for context). The v-shaped features taper downslope to form narrow, somewhat curved channels. The relationship seen here was interpreted by MOC scientists to be similar to seepage landforms on Earth that form where springs emerge on a slope and water runs downhill.

Once MGS achieved its Mapping Orbit in March 1999, the MOC was in a better position to take pictures of 10 times higher resolution than the Aerobraking AB1-07707 image. The opportunity to take a new picture of the proposed 'seepage' sites on the wall of the crater in southern Noachis finally arose in January 2000. The result is MOC image M11-00530, shown above in (top) and (C). This new close-up shows that the darkly-shaped scars host many small channels of only a few meters (yards) across. These small channels run downslope and coalesce at the apex (or point) of each 'v'. Amid the small channels are many large boulders, some of them the size of houses, that have eroded out of the crater wall. A 3-D view created using the AB1 and M11 images is shown in (D). The stereo picture (red-blue '3D' glasses required) emphasizes the presence of small channels and valleys, and shows that these valleys start

Local Time Variation of Water Ice Clouds on Mars as Observed by TES During Aerobraking.

NASA Astrophysics Data System (ADS)

AlJanaahi, A. A.; AlShamsi, M. R.; Smith, M. D.; Altunaiji, E. S.; Edwards, C. S.

2016-12-01

The large elliptical orbit during Mars Global Surveyor aerobraking enabled sampling the martian atmosphere over many local times. The Thermal Emission Spectrometer (TES) aerobraking spectra were taken between Mars Year 23, Ls=180° and Mars Year 24, Ls=30°. These early data from before the main "mapping" part of the mission have been mostly overlooked, and relatively little analysis has been done with them. These datasets have not been used before to study local time variation. Radiative transfer modeling is used to fit the spectra to retrieve surface and atmospheric temperature, and dust and water ice optical depths. Retrievals show significant and systematic variation in water ice cloud optical depth as a function of local time. Cloud optical depth is higher in the early morning (before 9:00) and in the evening (after 17:00) for all seasons observed (Ls=180°-30°). Clouds form consistently in the Tyrrhena region and in the area around Tharsis.

Low-energy near Earth asteroid capture using Earth flybys and aerobraking

NASA Astrophysics Data System (ADS)

Tan, Minghu; McInnes, Colin; Ceriotti, Matteo

2018-04-01

Since the Sun-Earth libration points L1 and L2 are regarded as ideal locations for space science missions and candidate gateways for future crewed interplanetary missions, capturing near-Earth asteroids (NEAs) around the Sun-Earth L1/L2 points has generated significant interest. Therefore, this paper proposes the concept of coupling together a flyby of the Earth and then capturing small NEAs onto Sun-Earth L1/L2 periodic orbits. In this capture strategy, the Sun-Earth circular restricted three-body problem (CRTBP) is used to calculate target Lypaunov orbits and their invariant manifolds. A periapsis map is then employed to determine the required perigee of the Earth flyby. Moreover, depending on the perigee distance of the flyby, Earth flybys with and without aerobraking are investigated to design a transfer trajectory capturing a small NEA from its initial orbit to the stable manifolds associated with Sun-Earth L1/L2 periodic orbits. Finally, a global optimization is carried out, based on a detailed design procedure for NEA capture using an Earth flyby. Results show that the NEA capture strategies using an Earth flyby with and without aerobraking both have the potential to be of lower cost in terms of energy requirements than a direct NEA capture strategy without the Earth flyby. Moreover, NEA capture with an Earth flyby also has the potential for a shorter flight time compared to the NEA capture strategy without the Earth flyby.

Space transfer concepts and analysis for exploration missions. Implementation plan and element description document (draft final). Volume 2: Cryo/aerobrake vehicle

NASA Technical Reports Server (NTRS)

1991-01-01

The cryogenic/aerobrake (CAB) and the cryogenic all-propulsive (CAP) concept designs developed in support of the Space Transfer Concepts and Analysis for Exploration Missions (STCAEM) study are presented. The evolution of the CAB and CAP concepts is described along with the requirements, guidelines and assumptions for the designs. Operating modes and options are defined and systems descriptions of the vehicles are presented. Artificial gravity configuration options and space and ground support systems are discussed. Finally, an implementation plan is presented which addresses technology needs, schedules, facilities, and costs.

A survey of aerobraking orbital transfer vehicle design concepts

NASA Technical Reports Server (NTRS)

Park, Chul

1987-01-01

The five existing design concepts of the aerobraking orbital transfer vehicle (namely, the raked sphere-cone designs, conical lifting-brake, raked elliptic-cone, lifting-body, and ballute) are reviewed and critiqued. Historical backgrounds, and the geometrical, aerothermal, and operational features of these designs are reviewed first. Then, the technological requirements for the vehicle (namely, navigation, aerodynamic stability and control, afterbody flow impingement, nonequilibrium radiation, convective heat-transfer rates, mission abort and multiple atmospheric passes, transportation and construction, and the payload-to-vehicle weight requirements) are delineated by summarizing the recent advancements made on these issues. Each of the five designs are critiqued and rated on these issues. The highest and the lowest ratings are given to the raked sphere-cone and the ballute design, respectively.

HUBBLE WATCHES THE RED PLANET AS MARS GLOBAL SURVEYOR BEGINS AEROBRAKING

NASA Technical Reports Server (NTRS)

2002-01-01

his NASA Hubble Space Telescope picture of Mars was taken on Sept. 12, one day after the arrival of the Mars Global Surveyor (MGS) spacecraft and only five hours before the beginning of autumn in the Martian northern hemisphere. (Mars is tilted on its axis like Earth, so it has similar seasonal changes, including an autumnal equinox when the Sun crosses Mars' equator from the northern to the southern hemisphere). This Hubble picture was taken in support of the MGS mission. Hubble is monitoring the Martian weather conditions during the early phases of MGS aerobraking; in particular, the detection of large dust storms are important inputs into the atmospheric models used by the MGS mission to plan aerobraking operations. Though a dusty haze fills the giant Hellas impact basin south of the dark fin-shaped feature Syrtis Major, the dust appears to be localized within Hellas. Unless the region covered expands significantly, the dust will not be of concern for MGS aerobraking. Other early signs of seasonal transitions on Mars are apparent in the Hubble picture. The northern polar ice cap is blanketed under a polar hood of clouds that typically start forming in late northern summer. As fall progresses, sunlight will dwindle in the north polar region and the seasonal polar cap of frozen carbon dioxide will start condensing onto the surface under these clouds. Hubble observations will continue until October 13, as MGS carefully uses the drag of the Martian atmosphere to circularize its orbit about the Red Planet. After mid-October, Mars will be too close to the Sun, in angular separation, for Hubble to safely view. The image is a composite of three separately filtered colored images taken with the Wide Field Planetary Camera 2 (WFPC2). Resolution is 35 miles (57 kilometers) per pixel (picture element). The Pathfinder landing site near Ares Valles is about 2200 miles (3600 kilometers) west of the center of this image, so was not visible during this observation. Mars was 158

Mars Earth Return Vehicle (MERV) Propulsion Options

NASA Technical Reports Server (NTRS)

Oleson, Steven R.; McGuire, Melissa L.; Burke, Laura; Fincannon, James; Warner, Joe; Williams, Glenn; Parkey, Thomas; Colozza, Tony; Fittje, Jim; Martini, Mike;

Hubble Watches the Red Planet as Mars Global Surveyor Begins Aerobraking

NASA Technical Reports Server (NTRS)

1997-01-01

[RIGHT] This NASA Hubble Space Telescope picture of Mars was taken on Sept. 12, one day after the arrival of the Mars Global Surveyor (MGS) spacecraft and only five hours before the beginning of autumn in the Martian northern hemisphere. (Mars is tilted on its axis like Earth, so it has similar seasonal changes, including an autumnal equinox when the Sun crosses Mars' equator from the northern to the southern hemisphere).

This Hubble picture was taken in support of the MGS mission. Hubble is monitoring the Martian weather conditions during the early phases of MGS aerobraking; in particular, the detection of large dust storms are important inputs into the atmospheric models used by the MGS mission to plan aerobraking operations.

Though a dusty haze fills the giant Hellas impact basin south of the dark fin-shaped feature Syrtis Major, the dust appears to be localized within Hellas. Unless the region covered expands significantly, the dust will not be of concern for MGS aerobraking.

Other early signs of seasonal transitions on Mars are apparent in the Hubble picture. The northern polar ice cap is blanketed under a polar hood of clouds that typically start forming in late northern summer. As fall progresses, sunlight will dwindle in the north polar region and the seasonal polar cap of frozen carbon dioxide will start condensing onto the surface under these clouds.

Hubble observations will continue until October 13, as MGS carefully uses the drag of the Martian atmosphere to circularize its orbit about the Red Planet. After mid-October, Mars will be too close to the Sun, in angular separation, for Hubble to safely view.

The image is a composite of three separately filtered colored images taken with the Wide Field Planetary Camera 2 (WFPC2). Resolution is 35 miles (57 kilometers) per pixel (picture element). The Pathfinder landing site near Ares Valles is about 2200 miles (3600 kilometers) west of the center of this image, so was not visible during this

Equilibrium radiative heating tables for aerobraking in the Martian atmosphere

NASA Astrophysics Data System (ADS)

Hartung, Lin C.; Sutton, Kenneth; Brauns, Frank

1990-05-01

Studies currently underway for Mars missions often envision the use of aerobraking for orbital capture at Mars. These missions generally involve blunt-nosed vehicles to dissipate the excess energy of the interplanetary transfer. Radiative heating may be of importance in these blunt-body flows because of the highly energetic shock layer around the blunt nose. In addition, the Martian atmosphere contains CO2, whose dissociation products are known to include strong radiators. An inviscid, equilibrium, stagnation point, radiation-coupled flow-field code has been developed for investigating blunt-body atmospheric entry. The method has been compared with ground-based and flight data for air, and reasonable agreement has been found. In the present work, the method was applied to a matrix of conditions in the Martian atmosphere. These conditions encompass most trajectories of interest for Mars exploration spacecraft. The predicted equilibrium radiative heating to the stagnation point of the vehicle is presented.

Equilibrium radiative heating tables for aerobraking in the Martian atmosphere

NASA Technical Reports Server (NTRS)

Hartung, Lin C.; Sutton, Kenneth; Brauns, Frank

1990-01-01

Studies currently underway for Mars missions often envision the use of aerobraking for orbital capture at Mars. These missions generally involve blunt-nosed vehicles to dissipate the excess energy of the interplanetary transfer. Radiative heating may be of importance in these blunt-body flows because of the highly energetic shock layer around the blunt nose. In addition, the Martian atmosphere contains CO2, whose dissociation products are known to include strong radiators. An inviscid, equilibrium, stagnation point, radiation-coupled flow-field code has been developed for investigating blunt-body atmospheric entry. The method has been compared with ground-based and flight data for air, and reasonable agreement has been found. In the present work, the method was applied to a matrix of conditions in the Martian atmosphere. These conditions encompass most trajectories of interest for Mars exploration spacecraft. The predicted equilibrium radiative heating to the stagnation point of the vehicle is presented.

Control algorithms for aerobraking in the Martian atmosphere

NASA Technical Reports Server (NTRS)

Ward, Donald T.; Shipley, Buford W., Jr.

1991-01-01

The Analytic Predictor Corrector (APC) and Energy Controller (EC) atmospheric guidance concepts were adapted to control an interplanetary vehicle aerobraking in the Martian atmosphere. Changes are made to the APC to improve its robustness to density variations. These changes include adaptation of a new exit phase algorithm, an adaptive transition velocity to initiate the exit phase, refinement of the reference dynamic pressure calculation and two improved density estimation techniques. The modified controller with the hybrid density estimation technique is called the Mars Hybrid Predictor Corrector (MHPC), while the modified controller with a polynomial density estimator is called the Mars Predictor Corrector (MPC). A Lyapunov Steepest Descent Controller (LSDC) is adapted to control the vehicle. The LSDC lacked robustness, so a Lyapunov tracking exit phase algorithm is developed to guide the vehicle along a reference trajectory. This algorithm, when using the hybrid density estimation technique to define the reference path, is called the Lyapunov Hybrid Tracking Controller (LHTC). With the polynomial density estimator used to define the reference trajectory, the algorithm is called the Lyapunov Tracking Controller (LTC). These four new controllers are tested using a six degree of freedom computer simulation to evaluate their robustness. The MHPC, MPC, LHTC, and LTC show dramatic improvements in robustness over the APC and EC.

Theoretical research program to study chemical reactions in AOTV bow shock tubes

NASA Technical Reports Server (NTRS)

Taylor, P.

1986-01-01

Progress in the development of computational methods for the characterization of chemical reactions in aerobraking orbit transfer vehicle (AOTV) propulsive flows is reported. Two main areas of code development were undertaken: (1) the implementation of CASSCF (complete active space self-consistent field) and SCF (self-consistent field) analytical first derivatives on the CRAY X-MP; and (2) the installation of the complete set of electronic structure codes on the CRAY 2. In the area of application calculations the main effort was devoted to performing full configuration-interaction calculations and using these results to benchmark other methods. Preprints describing some of the systems studied are included.

The Rationale/Benefits of Nuclear Thermal Rocket Propulsion for NASA's Lunar Space Transportation System

NASA Technical Reports Server (NTRS)

Borowski, Stanley K.

1994-01-01

The solid core nuclear thermal rocket (NTR) represents the next major evolutionary step in propulsion technology. With its attractive operating characteristics, which include high specific impulse (approximately 850-1000 s) and engine thrust-to-weight (approximately 4-20), the NTR can form the basis for an efficient lunar space transportation system (LTS) capable of supporting both piloted and cargo missions. Studies conducted at the NASA Lewis Research Center indicate that an NTR-based LTS could transport a fully-fueled, cargo-laden, lunar excursion vehicle to the Moon, and return it to low Earth orbit (LEO) after mission completion, for less initial mass in LEO than an aerobraked chemical system of the type studied by NASA during its '90-Day Study.' The all-propulsive NTR-powered LTS would also be 'fully reusable' and would have a 'return payload' mass fraction of approximately 23 percent--twice that of the 'partially reusable' aerobraked chemical system. Two NTR technology options are examined--one derived from the graphite-moderated reactor concept developed by NASA and the AEC under the Rover/NERVA (Nuclear Engine for Rocket Vehicle Application) programs, and a second concept, the Particle Bed Reactor (PBR). The paper also summarizes NASA's lunar outpost scenario, compares relative performance provided by different LTS concepts, and discusses important operational issues (e.g., reusability, engine 'end-of life' disposal, etc.) associated with using this important propulsion technology.

Affordable Launch Services using the Sport Orbit Transfer System

NASA Astrophysics Data System (ADS)

Goldstein, D. J.

2002-01-01

Despite many advances in small satellite technology, a low-cost, reliable method is needed to place spacecraft in their de- sired orbits. AeroAstro has developed the Small Payload ORbit Transfer (SPORTTM) system to provide a flexible low-cost orbit transfer capability, enabling small payloads to use low-cost secondary launch opportunities and still reach their desired final orbits. This capability allows small payloads to effectively use a wider variety of launch opportunities, including nu- merous under-utilized GTO slots. Its use, in conjunction with growing opportunities for secondary launches, enable in- creased access to space using proven technologies and highly reliable launch vehicles such as the Ariane family and the Starsem launcher. SPORT uses a suite of innovative technologies that are packaged in a simple, reliable, modular system. The command, control and data handling of SPORT is provided by the AeroAstro BitsyTM core electronics module. The Bitsy module also provides power regulation for the batteries and optional solar arrays. The primary orbital maneuvering capability is provided by a nitrous oxide monopropellant propulsion system. This system exploits the unique features of nitrous oxide, which in- clude self-pressurization, good performance, and safe handling, to provide a light-weight, low-cost and reliable propulsion capability. When transferring from a higher energy orbit to a lower energy orbit (i.e. GTO to LEO), SPORT uses aerobraking technol- ogy. After using the propulsion system to lower the orbit perigee, the aerobrake gradually slows SPORT via atmospheric drag. After the orbit apogee is reduced to the target level, an apogee burn raises the perigee and ends the aerobraking. At the conclusion of the orbit transfer maneuver, either the aerobrake or SPORT can be shed, as desired by the payload. SPORT uses a simple design for high reliability and a modular architecture for maximum mission flexibility. This paper will discuss the launch

Mars Lower Thermosphere Variability from Odyssey and MRO Aerobraking Measurements

NASA Astrophysics Data System (ADS)

Forbes, J. M.; Zhang, X.

2017-12-01

During the aerobraking phases of the Mars Odyssey (MO) and Mars Reconnaissance Orbiter (MRO) missions, accelerometer measurements of total mass density at periapsis altitudes near 105 km were made in Mars' polar regions (> 75o latitude) during Northern Hemisphere winter (MO, Ls = 288-297) and Southern Hemisphere winter (MRO, Ls = 69-87). These measurements cover overlapping local times spanning nearly 8 hours. Prior to the local time transition, the MO and MRO accelerometers sample the high-latitude regions at nearly the same latitudes (70-85o) and same local times (1800-1900), and after the transition periapsis precesses relatively quickly (over roughly 20-30 sols) from 80o to 20o latitude in each hemisphere while keeping the local time constant near 0200-0300 LT. These observations offer the unprecedented opportunity to compare and contrast the behaviors of Mars' polar and middle latitude regions under similar geographic, altitude and local time conditions in the two hemispheres (albeit during different years), which is the focus of this paper. Particularly noteworthy are the slow (mostly eastward) migrations of longitudinal features in both MO and MRO data, which suggest modulations of non-migrating tides by planetary waves with periods of order 15-20 days.

CFD analysis of hypersonic, chemically reacting flow fields

NASA Technical Reports Server (NTRS)

Edwards, T. A.

1993-01-01

Design studies are underway for a variety of hypersonic flight vehicles. The National Aero-Space Plane will provide a reusable, single-stage-to-orbit capability for routine access to low earth orbit. Flight-capable satellites will dip into the atmosphere to maneuver to new orbits, while planetary probes will decelerate at their destination by atmospheric aerobraking. To supplement limited experimental capabilities in the hypersonic regime, computational fluid dynamics (CFD) is being used to analyze the flow about these configurations. The governing equations include fluid dynamic as well as chemical species equations, which are being solved with new, robust numerical algorithms. Examples of CFD applications to hypersonic vehicles suggest an important role this technology will play in the development of future aerospace systems. The computational resources needed to obtain solutions are large, but solution adaptive grids, convergence acceleration, and parallel processing may make run times manageable.

Venus Global Reference Atmospheric Model

NASA Technical Reports Server (NTRS)

Justh, Hilary L.

2017-01-01

Venus Global Reference Atmospheric Model (Venus-GRAM) is an engineering-level atmospheric model developed by MSFC that is widely used for diverse mission applications including: Systems design; Performance analysis; Operations planning for aerobraking, Entry, Descent and Landing, and aerocapture; Is not a forecast model; Outputs include density, temperature, pressure, wind components, and chemical composition; Provides dispersions of thermodynamic parameters, winds, and density; Optional trajectory and auxiliary profile input files Has been used in multiple studies and proposals including NASA Engineering and Safety Center (NESC) Autonomous Aerobraking and various Discovery proposals; Released in 2005; Available at: https://software.nasa.gov/software/MFS-32314-1.

Aerobrake concepts for NTP systems study

NASA Technical Reports Server (NTRS)

Cruz, Manuel I.

1992-01-01

Design concepts are described for landing large spacecraft masses on the Mars surface in support of manned missions with interplanetary transportation using Nuclear Thermal Propulsion (NTP). Included are the mission and systems analyses, trade studies and sensitivity analyses, design analyses, technology assessment, and derived requirements to support this concept. The mission phases include the Mars de-orbit, entry, terminal descent, and terminal touchdown. The study focuses primarily on Mars surface delivery from orbit after Mars orbit insertion using an NTP. The requirements associated with delivery of logistical supplies, habitats, and other equipment on minimum energy Earth to Mars transfers are also addressed in a preliminary fashion.

Densities inferred from ESA's Venus Express aerobraking campaign at 130 km altitude

NASA Astrophysics Data System (ADS)

Bruinsma, Sean; Marty, Jean-Charles; Svedhem, Håkan; Williams, Adam; Mueller-Wodarg, Ingo

2015-04-01

In June-July 2014, ESA performed a planned aerobraking campaign with Venus Express to measure neutral densities above 130 km in Venus' atmosphere by means of the engineering accelerometers. To that purpose, the orbit perigee was lowered to approximately 130 km in order to enhance the atmospheric drag effect to the highest tolerable levels for the spacecraft; the accelerometer resolution and precision were not sufficient at higher altitudes. This campaign was requested as part of the Venus Express Atmospheric Drag Experiment (VExADE). A total of 18 orbits (i.e. days) were processed using the attitude quaternions to correctly orient the spacecraft bus and solar arrays in inertial space, which is necessary to accurately compute the exposed surface in the ram direction. The accelerometer data provide good measurements approximately from 130-140 km altitude; the length of the profiles is about 85 seconds, and they are on the early morning side (LST=4.5) at high northern latitude (70°N-82°N). The densities are a factor 2-3 larger than Hedin's VTS-3 thermosphere model, which is consistent with earlier results obtained via classical precise orbit determination at higher altitudes. Wavelike structures with amplitudes of 20% and more are detected, with wavelengths of about 100-500 km. We cannot entirely rule out that these waves are caused by the spacecraft or due to some unknown instrumental effect, but we estimate this probability to be very low.

Review of chemical-kinetic problems of future NASA missions. I - Earth entries

NASA Technical Reports Server (NTRS)

Park, Chul

1993-01-01

A number of chemical-kinetic problems related to phenomena occurring behind a shock wave surrounding an object flying in the earth atmosphere are discussed, including the nonequilibrium thermochemical relaxation phenomena occurring behind a shock wave surrounding the flying object, problems related to aerobraking maneuver, the radiation phenomena for shock velocities of up to 12 km/sec, and the determination of rate coefficients for ionization reactions and associated electron-impact ionization reactions. Results of experiments are presented in form of graphs and tables, giving data on the reaction rate coefficients for air, the ionization distances, thermodynamic properties behind a shock wave, radiative heat flux calculations, Damkoehler numbers for the ablation-product layer, together with conclusions.

Manned Mars Explorer project: Guidelines for a manned mission to the vicinity of Mars using Phobos as a staging outpost; schematic vehicle designs considering chemical and nuclear electric propulsion

NASA Technical Reports Server (NTRS)

Nolan, Sean; Neubek, Deb; Baxmann, C. J.

1988-01-01

The Manned Mars Explorer (MME) project responds to the fundamental problems of sending human beings to Mars in a mission scenario and schematic vehicle designs. The mission scenario targets an opposition class Venus inbound swingby for its trajectory with concentration on Phobos and/or Deimos as a staging base for initial and future Mars vicinity operations. Optional vehicles are presented as a comparison using nuclear electric power/propulsion technology. A Manned Planetary Vehicle and Crew Command Vehicle are used to accomplish the targeted mission. The Manned Planetary Vehicle utilizes the mature technology of chemical propulsion combined with an advanced aerobrake, tether and pressurized environment system. The Crew Command Vehicle is the workhorse of the mission performing many different functions including a manned Mars landing, and Phobos rendezvous.

Computational systems chemical biology.

PubMed

Oprea, Tudor I; May, Elebeoba E; Leitão, Andrei; Tropsha, Alexander

2011-01-01

There is a critical need for improving the level of chemistry awareness in systems biology. The data and information related to modulation of genes and proteins by small molecules continue to accumulate at the same time as simulation tools in systems biology and whole body physiologically based pharmacokinetics (PBPK) continue to evolve. We called this emerging area at the interface between chemical biology and systems biology systems chemical biology (SCB) (Nat Chem Biol 3: 447-450, 2007).The overarching goal of computational SCB is to develop tools for integrated chemical-biological data acquisition, filtering and processing, by taking into account relevant information related to interactions between proteins and small molecules, possible metabolic transformations of small molecules, as well as associated information related to genes, networks, small molecules, and, where applicable, mutants and variants of those proteins. There is yet an unmet need to develop an integrated in silico pharmacology/systems biology continuum that embeds drug-target-clinical outcome (DTCO) triplets, a capability that is vital to the future of chemical biology, pharmacology, and systems biology. Through the development of the SCB approach, scientists will be able to start addressing, in an integrated simulation environment, questions that make the best use of our ever-growing chemical and biological data repositories at the system-wide level. This chapter reviews some of the major research concepts and describes key components that constitute the emerging area of computational systems chemical biology.

Computational Systems Chemical Biology

PubMed Central

Oprea, Tudor I.; May, Elebeoba E.; Leitão, Andrei; Tropsha, Alexander

2013-01-01

There is a critical need for improving the level of chemistry awareness in systems biology. The data and information related to modulation of genes and proteins by small molecules continue to accumulate at the same time as simulation tools in systems biology and whole body physiologically-based pharmacokinetics (PBPK) continue to evolve. We called this emerging area at the interface between chemical biology and systems biology systems chemical biology, SCB (Oprea et al., 2007). The overarching goal of computational SCB is to develop tools for integrated chemical-biological data acquisition, filtering and processing, by taking into account relevant information related to interactions between proteins and small molecules, possible metabolic transformations of small molecules, as well as associated information related to genes, networks, small molecules and, where applicable, mutants and variants of those proteins. There is yet an unmet need to develop an integrated in silico pharmacology / systems biology continuum that embeds drug-target-clinical outcome (DTCO) triplets, a capability that is vital to the future of chemical biology, pharmacology and systems biology. Through the development of the SCB approach, scientists will be able to start addressing, in an integrated simulation environment, questions that make the best use of our ever-growing chemical and biological data repositories at the system-wide level. This chapter reviews some of the major research concepts and describes key components that constitute the emerging area of computational systems chemical biology. PMID:20838980

Chemical Tracking Systems: Not Your Usual Global Positioning System!

ERIC Educational Resources Information Center

Roy, Ken

2007-01-01

The haphazard storing and tracking of chemicals in the laboratory is a serious safety issue facing science teachers. To get control of your chemicals, try implementing a "chemical tracking system". A chemical tracking system (CTS) is a database of chemicals used in the laboratory. If implemented correctly, a CTS will reduce purchasing costs,…

Aerospace Vehicle Design, Spacecraft Section. Volume 3

NASA Technical Reports Server (NTRS)

1988-01-01

Research results are presented for the following groups: Project Mars Airplane Vehicle and Reconnaissance Instrument Carrier (MAVRIC), ACME, ARES, Project ACRONYM, Mars Aircraft Recepticle with Technical Instruments, Aerobraking, and Navigation (MARTIAN), and NOMADS. Each project is described by the following areas of focus: mission planning and costs; aerobraking systems; structures and thermal control systems; attitude and articulation control systems; comman and data control systems; science instrumentation; and power and propulsion systems.

A survey of chemical information systems

NASA Technical Reports Server (NTRS)

Dominick, Wayne D. (Editor); Shaikh, Aneesa Bashir

1985-01-01

A survey of the features, functions, and characteristics of a fairly wide variety of chemical information storage and retrieval systems currently in operation is given. The types of systems (together with an identification of the specific systems) addressed within this survey are as follows: patents and bibliographies (Derwent's Patent System; IFI Comprehensive Database; PULSAR); pharmacology and toxicology (Chemfile; PAGODE; CBF; HEEDA; NAPRALERT; MAACS); the chemical information system (CAS Chemical Registry System; SANSS; MSSS; CSEARCH; GINA; NMRLIT; CRYST; XTAL; PDSM; CAISF; RTECS Search System; AQUATOX; WDROP; OHMTADS; MLAB; Chemlab); spectra (OCETH; ASTM); crystals (CRYSRC); and physical properties (DETHERM). Summary characteristics and current trends in chemical information systems development are also examined.

The ram accelerator - A chemically driven mass launcher

NASA Technical Reports Server (NTRS)

Kaloupis, P.; Bruckner, A. P.

1988-01-01

The ram accelerator, a chemically propelled mass driver, is presented as a viable new approach for directly launching acceleration-insensitive payloads into low earth orbit. The propulsion principle is similar to that of a conventional air-breathing ramjet. The cargo vehicle resembles the center-body of a ramjet and travels through a tube filled with a pre-mixed fuel and oxidizer mixture. The launch tube acts as the outer cowling of the ramjet and the combustion process travels with the vehicle. Two drive modes of the ram accelerator propulsion system are described, which when used in sequence are capable of accelerating the vehicle to as high as 10 km/sec. The requirements are examined for placing a 2000 kg vehicle into a 500 km orbit with a minimum of on-board rocket propellant for circularization maneuvers. It is shown that aerodynamic heating during atmospheric transit results in very little ablation of the nose. An indirect orbital insertion scenario is selected, utilizing a three step maneuver consisting of two burns and aerobraking. An on-board propulsion system using storable liquid propellants is chosen in order to minimize propellant mass requirements, and the use of a parking orbit below the desired final orbit is suggested as a means to increase the flexibility of the mass launch concept. A vehicle design using composite materials is proposed that will best meet the structural requirements, and a preliminary launch tube design is presented.

The importance of operations, risk, and cost assessment to space transfer systems design

NASA Technical Reports Server (NTRS)

Ball, J. M.; Komerska, R. J.; Rowell, L. F.

1992-01-01

This paper examines several methodologies which contribute to comprehensive subsystem cost estimation. The example of a space-based lunar space transfer vehicle (STV) design is used to illustrate how including both primary and secondary factors into cost affects the decision of whether to use aerobraking or propulsion for earth orbit capture upon lunar return. The expected dominant cost factor in this decision is earth-to-orbit launch cost driven by STV mass. However, to quantify other significant cost factors, this cost comparison included a risk analysis to identify development and testing costs, a Taguchi design of experiments to determine a minimum mass aerobrake design, and a detailed operations analysis. As a result, the predicted cost advantage of aerobraking, while still positive, was subsequently reduced by about 30 percent compared to the simpler mass-based cost estimates.

Hazardous chemical tracking system (HAZ-TRAC)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bramlette, J D; Ewart, S M; Jones, C E

Westinghouse Idaho Nuclear Company, Inc. (WINCO) developed and implemented a computerized hazardous chemical tracking system, referred to as Haz-Trac, for use at the Idaho Chemical Processing Plant (ICPP). Haz-Trac is designed to provide a means to improve the accuracy and reliability of chemical information, which enhances the overall quality and safety of ICPP operations. The system tracks all chemicals and chemical components from the time they enter the ICPP until the chemical changes form, is used, or becomes a waste. The system runs on a Hewlett-Packard (HP) 3000 Series 70 computer. The system is written in COBOL and uses VIEW/3000,more » TurboIMAGE/DBMS 3000, OMNIDEX, and SPEEDWARE. The HP 3000 may be accessed throughout the ICPP, and from remote locations, using data communication lines. Haz-Trac went into production in October, 1989. Currently, over 1910 chemicals and chemical components are tracked on the system. More than 2500 personnel hours were saved during the first six months of operation. Cost savings have been realized by reducing the time needed to collect and compile reporting information, identifying and disposing of unneeded chemicals, and eliminating duplicate inventories. Haz-Trac maintains information required by the Superfund Amendment Reauthorization Act (SARA), the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) and the Occupational Safety and Health Administration (OSHA).« less

33 CFR 127.609 - Dry chemical systems.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Dry chemical systems. 127.609... Waterfront Facilities Handling Liquefied Natural Gas Firefighting § 127.609 Dry chemical systems. (a) Each marine transfer area for LNG must have a dry chemical system that provides at least two dry chemical...

33 CFR 127.609 - Dry chemical systems.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Dry chemical systems. 127.609... Waterfront Facilities Handling Liquefied Natural Gas Firefighting § 127.609 Dry chemical systems. (a) Each marine transfer area for LNG must have a dry chemical system that provides at least two dry chemical...

33 CFR 127.609 - Dry chemical systems.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Dry chemical systems. 127.609... Waterfront Facilities Handling Liquefied Natural Gas Firefighting § 127.609 Dry chemical systems. (a) Each marine transfer area for LNG must have a dry chemical system that provides at least two dry chemical...

33 CFR 127.609 - Dry chemical systems.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Dry chemical systems. 127.609... Waterfront Facilities Handling Liquefied Natural Gas Firefighting § 127.609 Dry chemical systems. (a) Each marine transfer area for LNG must have a dry chemical system that provides at least two dry chemical...

33 CFR 127.609 - Dry chemical systems.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Dry chemical systems. 127.609... Waterfront Facilities Handling Liquefied Natural Gas Firefighting § 127.609 Dry chemical systems. (a) Each marine transfer area for LNG must have a dry chemical system that provides at least two dry chemical...

A lateral guidance algorithm to reduce the post-aerobraking burn requirements for a lift-modulated orbital transfer vehicle. M.S. Thesis

NASA Technical Reports Server (NTRS)

Herman, G. C.

1986-01-01

A lateral guidance algorithm which controls the location of the line of intersection between the actual and desired orbital planes (the hinge line) is developed for the aerobraking phase of a lift-modulated orbital transfer vehicle. The on-board targeting algorithm associated with this lateral guidance algorithm is simple and concise which is very desirable since computation time and space are limited on an on-board flight computer. A variational equation which describes the movement of the hinge line is derived. Simple relationships between the plane error, the desired hinge line position, the position out-of-plane error, and the velocity out-of-plane error are found. A computer simulation is developed to test the lateral guidance algorithm for a variety of operating conditions. The algorithm does reduce the total burn magnitude needed to achieve the desired orbit by allowing the plane correction and perigee-raising burn to be combined in a single maneuver. The algorithm performs well under vacuum perigee dispersions, pot-hole density disturbance, and thick atmospheres. The results for many different operating conditions are presented.

A lunar transportation system

NASA Technical Reports Server (NTRS)

1986-01-01

Due to large amounts of oxygen required for space travel, a method of mining, transporting, and storing this oxygen in space would facilitate further space exploration. The following project deals specifically with the methods for transporting liquid oxygen from the lunar surface to the Lunar Orbit (LO) space station, and then to the Lower Earth Orbit (LEO) space station. Two vehicles were designed for operation between the LEO and LO space stations. The first of these vehicles is an aerobraked design vehicle. The Aerobrake Orbital Transfer Vehicle (OTV) is capable of transporting 5000 lbm of payload to LO while returning to LEO with 60,000 lbm of liquid oxygen, and thus meet mission requirements. The second vehicle can deliver 18,000 lbm of payload to LO and is capable of bringing 60,000 lbm of liquid oxygen back to LEO. A lunar landing vehicle was also designed for operation between LO and the established moon base. The use of an electromagnetic railgun as a method for launching the lunar lander was also investigated. The feasibility of the railgun is doubtful at this time. A system of spheres was also designed for proper storing and transporting of the liquid oxygen. The system assumes a safe means for transferring the liquid oxygen from tank to tank is operational. A sophisticated life support system was developed for both the OTV and the lunar lander. This system focuses on such factors as the vehicle environment, waste management, water requirements, food requirements, and oxygen requirements.

Optimization of Return Trajectories for Orbital Transfer Vehicle between Earth and Moon

NASA Technical Reports Server (NTRS)

Funase, Ryu; Tsuda, Yuichi; Kawaguchi, Jun'ichiro

2007-01-01

In this paper, optimum trajectories in Earth Transfer Orbit (ETO) for a lunar transportation system are proposed. This paper aims at improving the payload ratio of the reusable orbital transfer vehicle (OTV), which transports the payload from Low Earth Orbit (LEO) to Lunar Low Orbit (LLO) and returns to LEO. In ETO, we discuss ballistic flight using chemical propulsion, multi-impulse flight using electrical propulsion, and aero-assisted flight using aero-brake. The feasibility of the OTV is considered.

Soil chemical sensor and precision agricultural chemical delivery system and method

DOEpatents

Colburn, Jr., John W.

1991-01-01

A real time soil chemical sensor and precision agricultural chemical delivery system includes a plurality of ground-engaging tools in association with individual soil sensors which measure soil chemical levels. The system includes the addition of a solvent which rapidly saturates the soil/tool interface to form a conductive solution of chemicals leached from the soil. A multivalent electrode, positioned within a multivalent frame of the ground-engaging tool, applies a voltage or impresses a current between the electrode and the tool frame. A real-time soil chemical sensor and controller senses the electrochemical reaction resulting from the application of the voltage or current to the leachate, measures it by resistivity methods, and compares it against pre-set resistivity levels for substances leached by the solvent. Still greater precision is obtained by calibrating for the secondary current impressed through solvent-less soil. The appropriate concentration is then found and the servo-controlled delivery system applies the appropriate amount of fertilizer or agricultural chemicals substantially in the location from which the soil measurement was taken.

Soil chemical sensor and precision agricultural chemical delivery system and method

DOEpatents

Colburn, J.W. Jr.

1991-07-23

A real time soil chemical sensor and precision agricultural chemical delivery system includes a plurality of ground-engaging tools in association with individual soil sensors which measure soil chemical levels. The system includes the addition of a solvent which rapidly saturates the soil/tool interface to form a conductive solution of chemicals leached from the soil. A multivalent electrode, positioned within a multivalent frame of the ground-engaging tool, applies a voltage or impresses a current between the electrode and the tool frame. A real-time soil chemical sensor and controller senses the electrochemical reaction resulting from the application of the voltage or current to the leachate, measures it by resistivity methods, and compares it against pre-set resistivity levels for substances leached by the solvent. Still greater precision is obtained by calibrating for the secondary current impressed through solvent-less soil. The appropriate concentration is then found and the servo-controlled delivery system applies the appropriate amount of fertilizer or agricultural chemicals substantially in the location from which the soil measurement was taken. 5 figures.

46 CFR 154.1140 - Dry chemical system: General.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 5 2010-10-01 2010-10-01 false Dry chemical system: General. 154.1140 Section 154.1140... Firefighting System: Dry Chemical § 154.1140 Dry chemical system: General. Each liquefied flammable gas carrier must have a dry chemical firefighting system that meets §§ 154.1145 through 154.1170, Part 56 and...

46 CFR 154.1140 - Dry chemical system: General.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 5 2011-10-01 2011-10-01 false Dry chemical system: General. 154.1140 Section 154.1140... Firefighting System: Dry Chemical § 154.1140 Dry chemical system: General. Each liquefied flammable gas carrier must have a dry chemical firefighting system that meets §§ 154.1145 through 154.1170, Part 56 and...

46 CFR 154.1140 - Dry chemical system: General.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 5 2013-10-01 2013-10-01 false Dry chemical system: General. 154.1140 Section 154.1140... Firefighting System: Dry Chemical § 154.1140 Dry chemical system: General. Each liquefied flammable gas carrier must have a dry chemical firefighting system that meets §§ 154.1145 through 154.1170, Part 56 and...

46 CFR 154.1140 - Dry chemical system: General.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 5 2012-10-01 2012-10-01 false Dry chemical system: General. 154.1140 Section 154.1140... Firefighting System: Dry Chemical § 154.1140 Dry chemical system: General. Each liquefied flammable gas carrier must have a dry chemical firefighting system that meets §§ 154.1145 through 154.1170, Part 56 and...

46 CFR 154.1140 - Dry chemical system: General.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 5 2014-10-01 2014-10-01 false Dry chemical system: General. 154.1140 Section 154.1140... Firefighting System: Dry Chemical § 154.1140 Dry chemical system: General. Each liquefied flammable gas carrier must have a dry chemical firefighting system that meets §§ 154.1145 through 154.1170, Part 56 and...

Chemical Transformation System: Cloud Based ...

EPA Pesticide Factsheets

Integrated Environmental Modeling (IEM) systems that account for the fate/transport of organics frequently require physicochemical properties as well as transformation products. A myriad of chemical property databases exist but these can be difficult to access and often do not contain the proprietary chemicals that environmental regulators must consider. We are building the Chemical Transformation System (CTS) to facilitate model parameterization and analysis. CTS integrates a number of physicochemical property calculators into the system including EPI Suite, SPARC, TEST and ChemAxon. The calculators are heterogeneous in their scientific methodologies, technology implementations and deployment stacks. CTS also includes a chemical transformation processing engine that has been loaded with reaction libraries for human biotransformation, abiotic reduction and abiotic hydrolysis. CTS implements a common interface for the disparate calculators accepting molecular identifiers (SMILES, IUPAC, CAS#, user-drawn molecule) before submission for processing. To make the system as accessible as possible and provide a consistent programmatic interface, we wrapped the calculators in a standardized RESTful Application Programming Interface (API) which makes it capable of servicing a much broader spectrum of clients without constraints to interoperability such as operating system or programming language. CTS is hosted in a shared cloud environment, the Quantitative Environmental

Mars Global Surveyor Thermal Emission Spectrometer (TES) Observations of Dust Opacity During Aerobraking and Science Phasing

NASA Technical Reports Server (NTRS)

Smith, Michael D.; Pearl, John C.; Conrath, Barney J.; Christensen, Philip R.

1999-01-01

The Mars Global Surveyor (MGS) arrived at Mars in September 1997 near Mars southern spring equinox and has now provided monitoring of conditions in the Mars atmosphere for more than half a Mars year. The large majority of the spectra taken by the Thermal Emission Spectrometer (TES) are in a nadir geometry (downward looking mode) where Mars is observed through the atmosphere. Most of these contain the distinct spectral signature of atmospheric dust. For these nadir-geometry spectra we retrieve column-integrated infrared aerosol (dust) opacities. TES observations during the aerobraking and science-phasing portions of the MGS mission cover the seasonal range L(sub s)=184 deg - 28 deg. Excellent spatial coverage was obtained in the southern hemisphere. Northern hemisphere coverage is generally limited to narrow strips taken during the periapsis pass but is still very valuable. At the beginning of the mission the 9-(micron)meter dust opacity at midsouthern latitudes was low (0.15-0.25). As the season advanced through southern spring and into summer, TES observed several regional dust storms (including the Noachis dust storm of November 1997) where peak 9-(micron)meter dust opacities approached or exceeded unity, as well as numerous smaller local storms. Both large and small dust storms exhibited significant changes in both spatial coverage and intensity over a timescale of a day. Throughout southern spring and summer the region at the edge of the retreating southern seasonal polar ice cap was observed to be consistently more dusty than other latitudes.

Temporal Control over Transient Chemical Systems using Structurally Diverse Chemical Fuels.

PubMed

Chen, Jack L-Y; Maiti, Subhabrata; Fortunati, Ilaria; Ferrante, Camilla; Prins, Leonard J

2017-08-25

The next generation of adaptive, intelligent chemical systems will rely on a continuous supply of energy to maintain the functional state. Such systems will require chemical methodology that provides precise control over the energy dissipation process, and thus, the lifetime of the transiently activated function. This manuscript reports on the use of structurally diverse chemical fuels to control the lifetime of two different systems under dissipative conditions: transient signal generation and the transient formation of self-assembled aggregates. The energy stored in the fuels is dissipated at different rates by an enzyme, which installs a dependence of the lifetime of the active system on the chemical structure of the fuel. In the case of transient signal generation, it is shown that different chemical fuels can be used to generate a vast range of signal profiles, allowing temporal control over two orders of magnitude. Regarding self-assembly under dissipative conditions, the ability to control the lifetime using different fuels turns out to be particularly important as stable aggregates are formed only at well-defined surfactant/fuel ratios, meaning that temporal control cannot be achieved by simply changing the fuel concentration. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Film processing investigation. [improved chemical mixing system

NASA Technical Reports Server (NTRS)

Kelly, J. L.

1972-01-01

The present operational chemical mixing system for the Photographic Technology Division is evaluated, and the limitations are defined in terms of meeting the present and programmed chemical supply and delivery requirements. A major redesign of the entire chemical mixing, storage, analysis, and supply system is recommended. Other requirements for immediate and future implementations are presented.

Dietary antioxidant synergy in chemical and biological systems.

PubMed

Wang, Sunan; Zhu, Fan

2017-07-24

Antioxidant (AOX) synergies have been much reported in chemical ("test-tube" based assays focusing on pure chemicals), biological (tissue culture, animal and clinical models), and food systems during the past decade. Tentative synergies differ from each other due to the composition of AOX and the quantification methods. Regeneration mechanism responsible for synergy in chemical systems has been discussed. Solvent effects could contribute to the artifacts of synergy observed in the chemical models. Synergy in chemical models may hardly be relevant to biological systems that have been much less studied. Apparent discrepancies exist in understanding the molecular mechanisms in both chemical and biological systems. This review discusses diverse variables associated with AOX synergy and molecular scenarios for explanation. Future research to better utilize the synergy is suggested.

In-Space Chemical Propulsion System Model

NASA Technical Reports Server (NTRS)

Byers, David C.; Woodcock, Gordon; Benfield, Michael P. J.

2004-01-01

Multiple, new technologies for chemical systems are becoming available and include high temperature rockets, very light propellant tanks and structures, new bipropellant and monopropellant options, lower mass propellant control components, and zero boil off subsystems. Such technologies offer promise of increasing the performance of in-space chemical propulsion for energetic space missions. A mass model for pressure-fed, Earth and space-storable, advanced chemical propulsion systems (ACPS) was developed in support of the NASA MSFC In-Space Propulsion Program. Data from flight systems and studies defined baseline system architectures and subsystems and analyses were formulated for parametric scaling relationships for all ACPS subsystem. The paper will first provide summary descriptions of the approaches used for the systems and the subsystems and then present selected analyses to illustrate use of the model for missions with characteristics of current interest.

In-Space Chemical Propulsion System Model

NASA Technical Reports Server (NTRS)

Byers, David C.; Woodcock, Gordon; Benfield, M. P. J.

2004-01-01

Multiple, new technologies for chemical systems are becoming available and include high temperature rockets, very light propellant tanks and structures, new bipropellant and monopropellant options, lower mass propellant control components, and zero boil off subsystems. Such technologies offer promise of increasing the performance of in-space chemical propulsion for energetic space missions. A mass model for pressure-fed, Earth and space-storable, advanced chemical propulsion systems (ACPS) was developed in support of the NASA MSFC In-Space Propulsion Program. Data from flight systems and studies defined baseline system architectures and subsystems and analyses were formulated for parametric scaling relationships for all ACPS subsystems. The paper will first provide summary descriptions of the approaches used for the systems and the subsystems and then present selected analyses to illustrate use of the model for missions with characteristics of current interest.

Laser propulsion for orbit transfer - Laser technology issues

NASA Technical Reports Server (NTRS)

Horvath, J. C.; Frisbee, R. H.

1985-01-01

Using reasonable near-term mission traffic models (1991-2000 being the assumed operational time of the system) and the most current unclassified laser and laser thruster information available, it was found that space-based laser propulsion orbit transfer vehicles (OTVs) can outperform the aerobraked chemical OTV over a 10-year life-cycle. The conservative traffic models used resulted in an optimum laser power of about 1 MW per laser. This is significantly lower than the power levels considered in other studies. Trip time was taken into account only to the extent that the system was sized to accomplish the mission schedule.

Explosive destruction system for disposal of chemical munitions

DOEpatents

Tschritter, Kenneth L [Livermore, CA; Haroldsen, Brent L [Manteca, CA; Shepodd, Timothy J [Livermore, CA; Stofleth, Jerome H [Albuquerque, NM; DiBerardo, Raymond A [Baltimore, MD

2005-04-19

An explosive destruction system and method for safely destroying explosively configured chemical munitions. The system comprises a sealable, gas-tight explosive containment vessel, a fragment suppression system positioned in said vessel, and shaped charge means for accessing the interior of the munition when the munition is placed within the vessel and fragment suppression system. Also provided is a means for treatment and neutralization of the munition's chemical fills, and means for heating and agitating the contents of the vessel. The system is portable, rapidly deployable and provides the capability of explosively destroying and detoxifying chemical munitions within a gas-tight enclosure so that there is no venting of toxic or hazardous chemicals during detonation.

Systems metabolic engineering for chemicals and materials.

PubMed

Lee, Jeong Wook; Kim, Tae Yong; Jang, Yu-Sin; Choi, Sol; Lee, Sang Yup

2011-08-01

Metabolic engineering has contributed significantly to the enhanced production of various value-added and commodity chemicals and materials from renewable resources in the past two decades. Recently, metabolic engineering has been upgraded to the systems level (thus, systems metabolic engineering) by the integrated use of global technologies of systems biology, fine design capabilities of synthetic biology, and rational-random mutagenesis through evolutionary engineering. By systems metabolic engineering, production of natural and unnatural chemicals and materials can be better optimized in a multiplexed way on a genome scale, with reduced time and effort. Here, we review the recent trends in systems metabolic engineering for the production of chemicals and materials by presenting general strategies and showcasing representative examples. Copyright © 2011 Elsevier Ltd. All rights reserved.

Study of Intelligent Secure Chemical Inventory Management System

NASA Astrophysics Data System (ADS)

Shukran, Mohd Afizi Mohd; Naim Abdullah, Muhammad; Nazri Ismail, Mohd; Maskat, Kamaruzaman; Isa, Mohd Rizal Mohd; Shahfee Ishak, Muhammad; Adib Khairuddin, Muhamad

2017-08-01

Chemical inventory management system has been experiencing a new revolution from traditional inventory system which is manual to an automated inventory management system. In this paper, some review of the classic and modern approaches to chemical inventory management system has been discussed. This paper also describe about both type of inventory management. After a comparative analysis of the traditional method and automated method, it can be said that both methods have some distinctive characteristics. Moreover, the automated inventory management method has higher accuracy of calculation because the calculations are handled by software, eliminating possible errors and saving time. The automated inventory system also allows users and administrators to track the availability, location and consumption of chemicals. The study of this paper can provide forceful review analysis support for the chemical inventory management related research.

Modeling of Spacecraft Advanced Chemical Propulsion Systems

NASA Technical Reports Server (NTRS)

Benfield, Michael P. J.; Belcher, Jeremy A.

2004-01-01

This paper outlines the development of the Advanced Chemical Propulsion System (ACPS) model for Earth and Space Storable propellants. This model was developed by the System Technology Operation of SAIC-Huntsville for the NASA MSFC In-Space Propulsion Project Office. Each subsystem of the model is described. Selected model results will also be shown to demonstrate the model's ability to evaluate technology changes in chemical propulsion systems.

29 CFR 1910.161 - Fixed extinguishing systems, dry chemical.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 5 2011-07-01 2011-07-01 false Fixed extinguishing systems, dry chemical. 1910.161 Section... § 1910.161 Fixed extinguishing systems, dry chemical. (a) Scope and application. This section applies to all fixed extinguishing systems, using dry chemical as the extinguishing agent, installed to meet a...

29 CFR 1910.161 - Fixed extinguishing systems, dry chemical.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 5 2010-07-01 2010-07-01 false Fixed extinguishing systems, dry chemical. 1910.161 Section... § 1910.161 Fixed extinguishing systems, dry chemical. (a) Scope and application. This section applies to all fixed extinguishing systems, using dry chemical as the extinguishing agent, installed to meet a...

29 CFR 1910.161 - Fixed extinguishing systems, dry chemical.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 5 2013-07-01 2013-07-01 false Fixed extinguishing systems, dry chemical. 1910.161 Section... § 1910.161 Fixed extinguishing systems, dry chemical. (a) Scope and application. This section applies to all fixed extinguishing systems, using dry chemical as the extinguishing agent, installed to meet a...

29 CFR 1910.161 - Fixed extinguishing systems, dry chemical.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 5 2014-07-01 2014-07-01 false Fixed extinguishing systems, dry chemical. 1910.161 Section... § 1910.161 Fixed extinguishing systems, dry chemical. (a) Scope and application. This section applies to all fixed extinguishing systems, using dry chemical as the extinguishing agent, installed to meet a...

29 CFR 1910.161 - Fixed extinguishing systems, dry chemical.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 5 2012-07-01 2012-07-01 false Fixed extinguishing systems, dry chemical. 1910.161 Section... § 1910.161 Fixed extinguishing systems, dry chemical. (a) Scope and application. This section applies to all fixed extinguishing systems, using dry chemical as the extinguishing agent, installed to meet a...

Chemically Assisted Photocatalytic Oxidation System

NASA Technical Reports Server (NTRS)

Andino, Jean; Wu, Chang-Yu; Mazyck, David; Teixeira, Arthur A.

2009-01-01

The chemically assisted photocatalytic oxidation system (CAPOS) has been proposed for destroying microorganisms and organic chemicals that may be suspended in the air or present on surfaces of an air-handling system that ventilates an indoor environment. The CAPOS would comprise an upstream and a downstream stage that would implement a tandem combination of two partly redundant treatments. In the upstream stage, the air stream and, optionally, surfaces of the air-handling system would be treated with ozone, which would be generated from oxygen in the air by means of an electrical discharge or ultraviolet light. In the second stage, the air laden with ozone and oxidation products from the first stage would be made to flow in contact with a silica-titania photocatalyst exposed to ultraviolet light in the presence of water vapor. Hydroxyl radicals generated by the photocatalytic action would react with both carbon containing chemicals and microorganisms to eventually produce water and carbon dioxide, and ozone from the first stage would be photocatalytically degraded to O2. The net products of the two-stage treatment would be H2O, CO2, and O2.

Project SPARC: Space-Based Aeroassisted Reusable Craft

NASA Technical Reports Server (NTRS)

1990-01-01

Future United States' space facilities include a Space Station in low Earth orbit (LEO) and a Geosynchronous Operations Support Center, or GeoShack, in geosynchronous orbit (GEO). One possible mode of transfer between the two orbits is an aerobraking vehicle. When traveling from GEO to LEO, the Earth's atmosphere can be used to aerodynamically reduce the velocity of the vehicle, which reduces the amount of propulsive change in velocity required for the mission. An aerobrake is added to the vehicle for this purpose, but the additional mass increases propellant requirements. This increase must not exceed the amount of propellant saved during the aeropass. The design and development of an aerobraking vehicle that will transfer crew and cargo between the Space Station and GeoShack is examined. The vehicle is referred to as Project SPARC, a SPace-based Aeroassisted Reusable Craft. SPARC consists of a removable 45 ft diameter aerobrake, two modified Pratt and Whitney Advanced Expander Engines with a liquid oxygen/liquid hydrogen propellant, a removable crew module with a maximum capacity of five, and standard sized payload bays providing a maximum payload capacity of 28,000 lbm. The aerobrake, a rigid, ellipsoidally blunted elliptical cone, provides lift at zero angle-of-attack due to a 73 deg rake angle, and is covered with a flexible multi-layer thermal protection system. Maximum dry mass of the vehicle without payload is 20,535 lbm, and the maximum propellant requirement is 79,753 lbm at an oxidizer to fuel ratio of 6/1. Key advantages of SPARC include its capability to meet mission changes, and its removable aerobrake and crew module.

Engineered Barrier System: Physical and Chemical Environment

DOE Office of Scientific and Technical Information (OSTI.GOV)

P. Dixon

2004-04-26

The conceptual and predictive models documented in this Engineered Barrier System: Physical and Chemical Environment Model report describe the evolution of the physical and chemical conditions within the waste emplacement drifts of the repository. The modeling approaches and model output data will be used in the total system performance assessment (TSPA-LA) to assess the performance of the engineered barrier system and the waste form. These models evaluate the range of potential water compositions within the emplacement drifts, resulting from the interaction of introduced materials and minerals in dust with water seeping into the drifts and with aqueous solutions forming bymore » deliquescence of dust (as influenced by atmospheric conditions), and from thermal-hydrological-chemical (THC) processes in the drift. These models also consider the uncertainty and variability in water chemistry inside the drift and the compositions of introduced materials within the drift. This report develops and documents a set of process- and abstraction-level models that constitute the engineered barrier system: physical and chemical environment model. Where possible, these models use information directly from other process model reports as input, which promotes integration among process models used for total system performance assessment. Specific tasks and activities of modeling the physical and chemical environment are included in the technical work plan ''Technical Work Plan for: In-Drift Geochemistry Modeling'' (BSC 2004 [DIRS 166519]). As described in the technical work plan, the development of this report is coordinated with the development of other engineered barrier system analysis model reports.« less

Tautomerism in chemical information management systems

NASA Astrophysics Data System (ADS)

Warr, Wendy A.

2010-06-01

Tautomerism has an impact on many of the processes in chemical information management systems including novelty checking during registration into chemical structure databases; storage of structures; exact and substructure searching in chemical structure databases; and depiction of structures retrieved by a search. The approaches taken by 27 different software vendors and database producers are compared. It is hoped that this comparison will act as a discussion document that could ultimately improve databases and software for researchers in the future.

Chemical reactions in reverse micelle systems

DOEpatents

Matson, Dean W.; Fulton, John L.; Smith, Richard D.; Consani, Keith A.

1993-08-24

This invention is directed to conducting chemical reactions in reverse micelle or microemulsion systems comprising a substantially discontinuous phase including a polar fluid, typically an aqueous fluid, and a microemulsion promoter, typically a surfactant, for facilitating the formation of reverse micelles in the system. The system further includes a substantially continuous phase including a non-polar or low-polarity fluid material which is a gas under standard temperature and pressure and has a critical density, and which is generally a water-insoluble fluid in a near critical or supercritical state. Thus, the microemulsion system is maintained at a pressure and temperature such that the density of the non-polar or low-polarity fluid exceeds the critical density thereof. The method of carrying out chemical reactions generally comprises forming a first reverse micelle system including an aqueous fluid including reverse micelles in a water-insoluble fluid in the supercritical state. Then, a first reactant is introduced into the first reverse micelle system, and a chemical reaction is carried out with the first reactant to form a reaction product. In general, the first reactant can be incorporated into, and the product formed in, the reverse micelles. A second reactant can also be incorporated in the first reverse micelle system which is capable of reacting with the first reactant to form a product.

Linear systems on balancing chemical reaction problem

NASA Astrophysics Data System (ADS)

Kafi, R. A.; Abdillah, B.

2018-01-01

The concept of linear systems appears in a variety of applications. This paper presents a small sample of the wide variety of real-world problems regarding our study of linear systems. We show that the problem in balancing chemical reaction can be described by homogeneous linear systems. The solution of the systems is obtained by performing elementary row operations. The obtained solution represents the finding coefficients of chemical reaction. In addition, we present a computational calculation to show that mathematical software such as Matlab can be used to simplify completion of the systems, instead of manually using row operations.

30 CFR 75.1101-22 - Inspection of dry powder chemical systems.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Inspection of dry powder chemical systems. 75...-22 Inspection of dry powder chemical systems. (a) Each dry powder chemical system shall be examined... the dry powder chemical system has been actuated, all components of the system shall be cleaned...

30 CFR 75.1101-22 - Inspection of dry powder chemical systems.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Inspection of dry powder chemical systems. 75...-22 Inspection of dry powder chemical systems. (a) Each dry powder chemical system shall be examined... the dry powder chemical system has been actuated, all components of the system shall be cleaned...

30 CFR 75.1101-22 - Inspection of dry powder chemical systems.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Inspection of dry powder chemical systems. 75...-22 Inspection of dry powder chemical systems. (a) Each dry powder chemical system shall be examined... the dry powder chemical system has been actuated, all components of the system shall be cleaned...

30 CFR 75.1101-22 - Inspection of dry powder chemical systems.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Inspection of dry powder chemical systems. 75...-22 Inspection of dry powder chemical systems. (a) Each dry powder chemical system shall be examined... the dry powder chemical system has been actuated, all components of the system shall be cleaned...

A polarization system for persistent chemical detection

NASA Astrophysics Data System (ADS)

Craven-Jones, Julia; Appelhans, Leah; Couphos, Eric; Embree, Todd; Finnegan, Patrick; Goldstein, Dennis; Karelitz, David; LaCasse, Charles; Luk, Ting S.; Mahamat, Adoum; Massey, Lee; Tanbakuchi, Anthony; Washburn, Cody; Vigil, Steven

2015-09-01

We report on the development of a prototype polarization tag based system for detecting chemical vapors. The system primarily consists of two components, a chemically sensitive tag that experiences a change in its optical polarization properties when exposed to a specific chemical of interest, and an optical imaging polarimeter that is used to measure the polarization properties of the tags. Although the system concept could be extended to other chemicals, for the initial system prototype presented here the tags were developed to be sensitive to hydrogen fluoride (HF) vapors. HF is used in many industrial processes but is highly toxic and thus monitoring for its presence and concentration is often of interest for personnel and environmental safety. The tags are periodic multilayer structures that are produced using standard photolithographic processes. The polarimetric imager has been designed to measure the degree of linear polarization reflected from the tags in the short wave infrared. By monitoring the change in the reflected polarization signature from the tags, the polarimeter can be used to determine if the tag was exposed to HF gas. In this paper, a review of the system development effort and preliminary test results are presented and discussed, as well as our plan for future work.

Discrete stochastic simulation methods for chemically reacting systems.

PubMed

Cao, Yang; Samuels, David C

2009-01-01

Discrete stochastic chemical kinetics describe the time evolution of a chemically reacting system by taking into account the fact that, in reality, chemical species are present with integer populations and exhibit some degree of randomness in their dynamical behavior. In recent years, with the development of new techniques to study biochemistry dynamics in a single cell, there are increasing studies using this approach to chemical kinetics in cellular systems, where the small copy number of some reactant species in the cell may lead to deviations from the predictions of the deterministic differential equations of classical chemical kinetics. This chapter reviews the fundamental theory related to stochastic chemical kinetics and several simulation methods based on that theory. We focus on nonstiff biochemical systems and the two most important discrete stochastic simulation methods: Gillespie's stochastic simulation algorithm (SSA) and the tau-leaping method. Different implementation strategies of these two methods are discussed. Then we recommend a relatively simple and efficient strategy that combines the strengths of the two methods: the hybrid SSA/tau-leaping method. The implementation details of the hybrid strategy are given here and a related software package is introduced. Finally, the hybrid method is applied to simple biochemical systems as a demonstration of its application.

KENNEDY SPACE CENTER, FLA. - United Space Alliance employees Jeremy Schwarz (left) and Chris Keeling install new tiles on the heat shield of main engine 1 for the orbiter Discovery. A heat shield is a protective layer on a spacecraft designed to protect it from the high temperatures, usually those that result from aerobraking during reentry into the Earth’s atmosphere.

NASA Image and Video Library

2003-09-23

KENNEDY SPACE CENTER, FLA. - United Space Alliance employees Jeremy Schwarz (left) and Chris Keeling install new tiles on the heat shield of main engine 1 for the orbiter Discovery. A heat shield is a protective layer on a spacecraft designed to protect it from the high temperatures, usually those that result from aerobraking during reentry into the Earth’s atmosphere.

Control and optimization system and method for chemical looping processes

DOEpatents

Lou, Xinsheng; Joshi, Abhinaya; Lei, Hao

2014-06-24

A control system for optimizing a chemical loop system includes one or more sensors for measuring one or more parameters in a chemical loop. The sensors are disposed on or in a conduit positioned in the chemical loop. The sensors generate one or more data signals representative of an amount of solids in the conduit. The control system includes a data acquisition system in communication with the sensors and a controller in communication with the data acquisition system. The data acquisition system receives the data signals and the controller generates the control signals. The controller is in communication with one or more valves positioned in the chemical loop. The valves are configured to regulate a flow of the solids through the chemical loop.

Control and optimization system and method for chemical looping processes

DOEpatents

Lou, Xinsheng; Joshi, Abhinaya; Lei, Hao

2015-02-17

A control system for optimizing a chemical loop system includes one or more sensors for measuring one or more parameters in a chemical loop. The sensors are disposed on or in a conduit positioned in the chemical loop. The sensors generate one or more data signals representative of an amount of solids in the conduit. The control system includes a data acquisition system in communication with the sensors and a controller in communication with the data acquisition system. The data acquisition system receives the data signals and the controller generates the control signals. The controller is in communication with one or more valves positioned in the chemical loop. The valves are configured to regulate a flow of the solids through the chemical loop.

30 CFR 75.1101-14 - Installation of dry powder chemical systems.

Code of Federal Regulations, 2014 CFR

2014-07-01

...' Laboratories, Inc., or Factory Mutual Engineering Corp. (c) The components of each dry powder chemical system... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Installation of dry powder chemical systems. 75...-14 Installation of dry powder chemical systems. (a) Self-contained dry powder chemical systems shall...

30 CFR 75.1101-14 - Installation of dry powder chemical systems.

Code of Federal Regulations, 2012 CFR

2012-07-01

...' Laboratories, Inc., or Factory Mutual Engineering Corp. (c) The components of each dry powder chemical system... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Installation of dry powder chemical systems. 75...-14 Installation of dry powder chemical systems. (a) Self-contained dry powder chemical systems shall...

30 CFR 75.1101-14 - Installation of dry powder chemical systems.

Code of Federal Regulations, 2011 CFR

2011-07-01

...' Laboratories, Inc., or Factory Mutual Engineering Corp. (c) The components of each dry powder chemical system... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Installation of dry powder chemical systems. 75...-14 Installation of dry powder chemical systems. (a) Self-contained dry powder chemical systems shall...

30 CFR 75.1101-14 - Installation of dry powder chemical systems.

Code of Federal Regulations, 2010 CFR

2010-07-01

...' Laboratories, Inc., or Factory Mutual Engineering Corp. (c) The components of each dry powder chemical system... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Installation of dry powder chemical systems. 75...-14 Installation of dry powder chemical systems. (a) Self-contained dry powder chemical systems shall...

30 CFR 75.1101-14 - Installation of dry powder chemical systems.

Code of Federal Regulations, 2013 CFR

2013-07-01

...' Laboratories, Inc., or Factory Mutual Engineering Corp. (c) The components of each dry powder chemical system... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Installation of dry powder chemical systems. 75...-14 Installation of dry powder chemical systems. (a) Self-contained dry powder chemical systems shall...

Chemical aspects of the formation of the solar system

NASA Technical Reports Server (NTRS)

Arrhenius, G.

1978-01-01

Application of Alfven's theory for the formation of the solar system and the constraints imposed by the chemical composition of space materials are discussed with reference to chemical processes involved in the formation of the solar system. Evidence for the chemical properties of the space medium and the chemical consequences of the postulated physical differentiation processes are outlined, and interpretations based on structure and composition of meteorite material are indicated. A large range of topics, including processes involving chemical differentiation, temperature effects, and isotope fractionation, are examined.

Chemical heat pump and chemical energy storage system

DOEpatents

Clark, Edward C.; Huxtable, Douglas D.

1985-08-06

A chemical heat pump and storage system employs sulfuric acid and water. In one form, the system includes a generator and condenser, an evaporator and absorber, aqueous acid solution storage and water storage. During a charging cycle, heat is provided to the generator from a heat source to concentrate the acid solution while heat is removed from the condenser to condense the water vapor produced in the generator. Water is then stored in the storage tank. Heat is thus stored in the form of chemical energy in the concentrated acid. The heat removed from the water vapor can be supplied to a heat load of proper temperature or can be rejected. During a discharge cycle, water in the evaporator is supplied with heat to generate water vapor, which is transmitted to the absorber where it is condensed and absorbed into the concentrated acid. Both heats of dilution and condensation of water are removed from the thus diluted acid. During the discharge cycle the system functions as a heat pump in which heat is added to the system at a low temperature and removed from the system at a high temperature. The diluted acid is stored in an acid storage tank or is routed directly to the generator for reconcentration. The generator, condenser, evaporator, and absorber all are operated under pressure conditions specified by the desired temperature levels for a given application. The storage tanks, however, can be maintained at or near ambient pressure conditions. In another form, the heat pump system is employed to provide usable heat from waste process heat by upgrading the temperature of the waste heat.

High energy chemical laser system

DOEpatents

Gregg, D.W.; Pearson, R.K.

1975-12-23

A high energy chemical laser system is described wherein explosive gaseous mixtures of a reducing agent providing hydrogen isotopes and interhalogen compounds are uniformly ignited by means of an electrical discharge, flash- photolysis or an electron beam. The resulting chemical explosion pumps a lasing chemical species, hydrogen fluoride or deuterium fluoride which is formed in the chemical reaction. The generated lasing pulse has light frequencies in the 3- micron range. Suitable interhalogen compounds include bromine trifluoride (BrF$sub 3$), bromine pentafluoride (BrF$sub 5$), chlorine monofluoride (ClF), chlorine trifluoride (ClF$sub 3$), chlorine pentafluoride (ClF$sub 5$), iodine pentafluoride (IF$sub 5$), and iodine heptafluoride (IF$sub 7$); and suitable reducing agents include hydrogen (H$sub 2$), hydrocarbons such as methane (CH$sub 4$), deuterium (D$sub 2$), and diborane (B$sub 2$H$sub 6$), as well as combinations of the gaseous compound and/or molecular mixtures of the reducing agent.

30 CFR 75.1101-13 - Dry powder chemical systems; general.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Dry powder chemical systems; general. 75.1101-13 Section 75.1101-13 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR...-13 Dry powder chemical systems; general. Self-contained dry powder chemical systems may be installed...

30 CFR 75.1101-13 - Dry powder chemical systems; general.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Dry powder chemical systems; general. 75.1101-13 Section 75.1101-13 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR...-13 Dry powder chemical systems; general. Self-contained dry powder chemical systems may be installed...

30 CFR 75.1101-13 - Dry powder chemical systems; general.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Dry powder chemical systems; general. 75.1101-13 Section 75.1101-13 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR...-13 Dry powder chemical systems; general. Self-contained dry powder chemical systems may be installed...

30 CFR 75.1101-13 - Dry powder chemical systems; general.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Dry powder chemical systems; general. 75.1101-13 Section 75.1101-13 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR...-13 Dry powder chemical systems; general. Self-contained dry powder chemical systems may be installed...

30 CFR 75.1101-13 - Dry powder chemical systems; general.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Dry powder chemical systems; general. 75.1101-13 Section 75.1101-13 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR...-13 Dry powder chemical systems; general. Self-contained dry powder chemical systems may be installed...

Guidance trajectories for aeroassisted orbital transfer

NASA Technical Reports Server (NTRS)

Miele, A.

1990-01-01

Research on aerobraking guidance schemes is presented. The intent is to produce aerobraking guidance trajectories exhibiting many of the desirable characteristics of optimal aerobraking trajectories. Both one-control schemes and two-control schemes are studied. The research is in the interest of aeroassisted flight experiment vehicles (AFE) and aeroassisted orbital transfer (AOT) vehicles.

The functional therapeutic chemical classification system.

PubMed

Croset, Samuel; Overington, John P; Rebholz-Schuhmann, Dietrich

2014-03-15

Drug repositioning is the discovery of new indications for compounds that have already been approved and used in a clinical setting. Recently, some computational approaches have been suggested to unveil new opportunities in a systematic fashion, by taking into consideration gene expression signatures or chemical features for instance. We present here a novel method based on knowledge integration using semantic technologies, to capture the functional role of approved chemical compounds. In order to computationally generate repositioning hypotheses, we used the Web Ontology Language to formally define the semantics of over 20 000 terms with axioms to correctly denote various modes of action (MoA). Based on an integration of public data, we have automatically assigned over a thousand of approved drugs into these MoA categories. The resulting new resource is called the Functional Therapeutic Chemical Classification System and was further evaluated against the content of the traditional Anatomical Therapeutic Chemical Classification System. We illustrate how the new classification can be used to generate drug repurposing hypotheses, using Alzheimers disease as a use-case. https://www.ebi.ac.uk/chembl/ftc; https://github.com/loopasam/ftc. croset@ebi.ac.uk Supplementary data are available at Bioinformatics online.

Lightweight autonomous chemical identification system (LACIS)

NASA Astrophysics Data System (ADS)

Lozos, George; Lin, Hai; Burch, Timothy

2012-06-01

Smiths Detection and Intelligent Optical Systems have developed prototypes for the Lightweight Autonomous Chemical Identification System (LACIS) for the US Department of Homeland Security. LACIS is to be a handheld detection system for Chemical Warfare Agents (CWAs) and Toxic Industrial Chemicals (TICs). LACIS is designed to have a low limit of detection and rapid response time for use by emergency responders and could allow determination of areas having dangerous concentration levels and if protective garments will be required. Procedures for protection of responders from hazardous materials incidents require the use of protective equipment until such time as the hazard can be assessed. Such accurate analysis can accelerate operations and increase effectiveness. LACIS is to be an improved point detector employing novel CBRNE detection modalities that includes a militaryproven ruggedized ion mobility spectrometer (IMS) with an array of electro-resistive sensors to extend the range of chemical threats detected in a single device. It uses a novel sensor data fusion and threat classification architecture to interpret the independent sensor responses and provide robust detection at low levels in complex backgrounds with minimal false alarms. The performance of LACIS prototypes have been characterized in independent third party laboratory tests at the Battelle Memorial Institute (BMI, Columbus, OH) and indoor and outdoor field tests at the Nevada National Security Site (NNSS). LACIS prototypes will be entering operational assessment by key government emergency response groups to determine its capabilities versus requirements.

Chemical dosimetry system for criticality accidents.

PubMed

Miljanić, Saveta; Ilijas, Boris

2004-01-01

Ruder Bosković Institute (RBI) criticality dosimetry system consists of a chemical dosimetry system for measuring the total (neutron + gamma) dose, and a thermoluminescent (TL) dosimetry system for a separate determination of the gamma ray component. The use of the chemical dosemeter solution chlorobenzene-ethanol-trimethylpentane (CET) is based on the radiolytic formation of hydrochloric acid, which protonates a pH indicator, thymolsulphonphthalein. The high molar absorptivity of its red form at 552 nm is responsible for a high sensitivity of the system: doses in the range 0.2-15 Gy can be measured. The dosemeter has been designed as a glass ampoule filled with the CET solution and inserted into a pen-shaped plastic holder. For dose determinations, a newly constructed optoelectronic reader has been used. The RBI team took part in the International Intercomparison of Criticality Accident Dosimetry Systems at the SILENE Reactor, Valduc, June 2002, with the CET dosimetry system. For gamma ray dose determination TLD-700 TL detectors were used. The results obtained with CET dosemeter show very good agreement with the reference values.

Advanced physical-chemical life support systems research

NASA Technical Reports Server (NTRS)

Evanich, Peggy L.

1988-01-01

A proposed NASA space research and technology development program will provide adequate data for designing closed loop life support systems for long-duration manned space missions. This program, referred to as the Pathfinder Physical-Chemical Closed Loop Life Support Program, is to identify and develop critical chemical engineering technologies for the closure of air and water loops within the spacecraft, surface habitats or mobility devices. Computerized simulation can be used both as a research and management tool. Validated models will guide the selection of the best known applicable processes and in the development of new processes. For the integration of the habitat system, a biological subsystem would be introduced to provide food production and to enhance the physical-chemical life support functions on an ever-increasing basis.

Construction of a Linux based chemical and biological information system.

PubMed

Molnár, László; Vágó, István; Fehér, András

2003-01-01

A chemical and biological information system with a Web-based easy-to-use interface and corresponding databases has been developed. The constructed system incorporates all chemical, numerical and textual data related to the chemical compounds, including numerical biological screen results. Users can search the database by traditional textual/numerical and/or substructure or similarity queries through the web interface. To build our chemical database management system, we utilized existing IT components such as ORACLE or Tripos SYBYL for database management and Zope application server for the web interface. We chose Linux as the main platform, however, almost every component can be used under various operating systems.

Development of a Persistent Chemical Agent Simulator System (PCASS)

NASA Technical Reports Server (NTRS)

Mcginness, W. G.

1983-01-01

The development of a persistent chemical agent simulation system (PCASS) is described. This PCASS is to be used for the military training of troops to simulate actual chemical warfare. The purpose of this system is to facilitate in the determination of chemical contamination and effectiveness of decontamination for training purposes. The fluorescent tracer employed has no daylight activation, but yet is easily removed with a decontaminate solution or water and surfactants. Also employed is a time delayed color developing system. When an individual is subjected to the PCASS and does not decontaminate adequately, red blotches or red coloration will develop as a function of time and temperature. The intent of this is to simulate the delayed chemical reaction of mustard contaminates.

30 CFR 75.1101-17 - Sealing of dry powder chemical systems.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Sealing of dry powder chemical systems. 75.1101-17 Section 75.1101-17 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR...-17 Sealing of dry powder chemical systems. Each dry powder chemical system shall be adequately sealed...

30 CFR 75.1101-17 - Sealing of dry powder chemical systems.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Sealing of dry powder chemical systems. 75.1101-17 Section 75.1101-17 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR...-17 Sealing of dry powder chemical systems. Each dry powder chemical system shall be adequately sealed...

30 CFR 75.1101-20 - Safeguards for dry powder chemical systems.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Safeguards for dry powder chemical systems. 75...-20 Safeguards for dry powder chemical systems. Adequate guards shall be provided along all belt conveyors in the vicinity of each dry powder chemical system to protect persons whose vision is restricted...

30 CFR 75.1101-20 - Safeguards for dry powder chemical systems.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Safeguards for dry powder chemical systems. 75...-20 Safeguards for dry powder chemical systems. Adequate guards shall be provided along all belt conveyors in the vicinity of each dry powder chemical system to protect persons whose vision is restricted...

30 CFR 75.1101-17 - Sealing of dry powder chemical systems.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Sealing of dry powder chemical systems. 75.1101-17 Section 75.1101-17 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR...-17 Sealing of dry powder chemical systems. Each dry powder chemical system shall be adequately sealed...

30 CFR 75.1101-20 - Safeguards for dry powder chemical systems.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Safeguards for dry powder chemical systems. 75...-20 Safeguards for dry powder chemical systems. Adequate guards shall be provided along all belt conveyors in the vicinity of each dry powder chemical system to protect persons whose vision is restricted...

30 CFR 75.1101-20 - Safeguards for dry powder chemical systems.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Safeguards for dry powder chemical systems. 75...-20 Safeguards for dry powder chemical systems. Adequate guards shall be provided along all belt conveyors in the vicinity of each dry powder chemical system to protect persons whose vision is restricted...

30 CFR 75.1101-17 - Sealing of dry powder chemical systems.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Sealing of dry powder chemical systems. 75.1101-17 Section 75.1101-17 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR...-17 Sealing of dry powder chemical systems. Each dry powder chemical system shall be adequately sealed...

KENNEDY SPACE CENTER, FLA. - United Space Alliance employees (from left) Daryl Burke, Jay Beason and Tom Summers check new tiles installed on the heat shield of main engine 1 for the orbiter Discovery. A heat shield is a protective layer on a spacecraft designed to protect it from the high temperatures, usually those that result from aerobraking during reentry into the Earth’s atmosphere.

NASA Image and Video Library

2003-09-23

KENNEDY SPACE CENTER, FLA. - United Space Alliance employees (from left) Daryl Burke, Jay Beason and Tom Summers check new tiles installed on the heat shield of main engine 1 for the orbiter Discovery. A heat shield is a protective layer on a spacecraft designed to protect it from the high temperatures, usually those that result from aerobraking during reentry into the Earth’s atmosphere.

Stochastic thermodynamics and entropy production of chemical reaction systems

NASA Astrophysics Data System (ADS)

Tomé, Tânia; de Oliveira, Mário J.

2018-06-01

We investigate the nonequilibrium stationary states of systems consisting of chemical reactions among molecules of several chemical species. To this end, we introduce and develop a stochastic formulation of nonequilibrium thermodynamics of chemical reaction systems based on a master equation defined on the space of microscopic chemical states and on appropriate definitions of entropy and entropy production. The system is in contact with a heat reservoir and is placed out of equilibrium by the contact with particle reservoirs. In our approach, the fluxes of various types, such as the heat and particle fluxes, play a fundamental role in characterizing the nonequilibrium chemical state. We show that the rate of entropy production in the stationary nonequilibrium state is a bilinear form in the affinities and the fluxes of reaction, which are expressed in terms of rate constants and transition rates, respectively. We also show how the description in terms of microscopic states can be reduced to a description in terms of the numbers of particles of each species, from which follows the chemical master equation. As an example, we calculate the rate of entropy production of the first and second Schlögl reaction models.

Environmental sentinel biomonitors: integrated response systems for monitoring toxic chemicals

NASA Astrophysics Data System (ADS)

van der Schalie, William H.; Reuter, Roy; Shedd, Tommy R.; Knechtges, Paul L.

2002-02-01

Operational environments for military forces are becoming potentially more dangerous due to the increased number, use, and misuse of toxic chemicals across the entire range of military missions. Defense personnel may be exposed to harmful chemicals as a result of industrial accidents or intentional or unintentional action of enemy, friendly forces, or indigenous populations. While there has been a significant military effort to enable forces to operate safely and survive and sustain operations in nuclear, biological, chemical warfare agent environments, until recently there has not been a concomitant effort associated with potential adverse health effects from exposures of deployed personnel to toxic industrial chemicals. To provide continuous real-time toxicity assessments across a broad spectrum of individual chemicals or chemical mixtures, an Environmental Sentinel Biomonitor (ESB) system concept is proposed. An ESB system will integrate data from one or more platforms of biologically-based systems and chemical detectors placed in the environment to sense developing toxic conditions and transmit time-relevant data for use in risk assessment, mitigation, and/or management. Issues, challenges, and next steps for the ESB system concept are described, based in part on discussions at a September 2001 workshop sponsored by the U.S. Army Center for Environmental Health Research.

Green Chemical Treatments for Heating and Cooling Systems

DTIC Science & Technology

2006-09-01

Legionella pneumophila bacterium, which causes Legion- naire’s Disease. 2.3 Steam Line Treatment The third and final product in the Green Chemistry...ER D C/ CE R L TR -0 6 -2 9 Green Chemical Treatments for Heating and Cooling Systems Susan A. Drozdz and Vincent F. Hock September...CERL TR-06-29 September 2006 Green Chemical Treatments for Heating and Cooling Systems Susan A. Drozdz and Vincent F. Hock Construction

Aerothermodynamics of the Mars Global Surveyor Spacecraft

NASA Technical Reports Server (NTRS)

Shane, Russell W.; Tolson, Robert H.

1998-01-01

The aerothermodynamics characteristics of the Mars Global Surveyor spacecraft are investigated and reported. These results have been used by the Mars Global Surveyor mission planners to design the aerobraking phase of the mission. Analytical and Direct Simulation Monte Carlo computer codes were used with a detailed, three dimensional model of the spacecraft to evaluate spacecraft aerobraking characteristics for flight in free molecular and transitional flow regimes. The spacecraft is found to be aerodynamically stable in aerobraking and planned contingency configurations. Aerodynamic forces, moments, and heating are found to be highly dependent on atmospheric density. Accommodation coefficient. is seen to strongly influence drag coefficient. Transitional flow effects are found to reduce overall solar panel heating. Attitude control thruster plumes are shown to interact with the freestream, diminishing the effectiveness of the attitude control system and even leading to thrust reversal. These plume-freestream interaction effects are found to be highly dependent on freestream density.

Discreteness-induced concentration inversion in mesoscopic chemical systems.

PubMed

Ramaswamy, Rajesh; González-Segredo, Nélido; Sbalzarini, Ivo F; Grima, Ramon

2012-04-10

Molecular discreteness is apparent in small-volume chemical systems, such as biological cells, leading to stochastic kinetics. Here we present a theoretical framework to understand the effects of discreteness on the steady state of a monostable chemical reaction network. We consider independent realizations of the same chemical system in compartments of different volumes. Rate equations ignore molecular discreteness and predict the same average steady-state concentrations in all compartments. However, our theory predicts that the average steady state of the system varies with volume: if a species is more abundant than another for large volumes, then the reverse occurs for volumes below a critical value, leading to a concentration inversion effect. The addition of extrinsic noise increases the size of the critical volume. We theoretically predict the critical volumes and verify, by exact stochastic simulations, that rate equations are qualitatively incorrect in sub-critical volumes.

[Prospects in getting accordance between chemical analytic control means and medical technical requirements to safety system concerning chemical weapons destruction].

PubMed

Rembovskiĭ, V R; Mogilenkova, L A; Savel'eva, E I

2005-01-01

The major unit monitoring chemical weapons destruction objects is a system of chemical analyticcontrol over the technologic process procedures and possibility of environment and workplace pollution withtoxicchemicals and their destruction products. At the same time, physical and chemical control means meet sanitary and hygienic requirements incompletely. To provide efficient control, internationally recognized approaches should be adapted to features of Russian system monitoring pollution of chemical weapons destruction objects with toxic chemicals.

Effectiveness of the SYSTEM 1E Liquid Chemical Sterilant Processing System for reprocessing duodenoscopes.

PubMed

McDonnell, Gerald; Ehrman, Michele; Kiess, Sara

2016-06-01

A troubling number of health care-acquired infection outbreaks and transmission events, some involving highly resistant microbial pathogens and resulting in serious patient outcomes, have been traced to reusable, high-level disinfected duodenoscopes in the United States. The Food and Drug Administration (FDA) requested a study be conducted to verify liquid chemical sterilization efficacy of SYSTEM 1E(®) Liquid Chemical Sterilant Processing System (STERIS Corporation, Mentor, OH) with varied duodenoscope designs under especially arduous conditions. Here, we describe the system's performance under worst case SYSTEM 1E(®) processing conditions. The test protocol challenged the system's performance by running a fractional cycle to evaluate reduction of recoverable test spores from heavily contaminated endoscopes, including all channels and each distal tip, under worst case SYSTEM 1E(®) processing conditions. All devices were successfully liquid chemically sterilized, showing greater than a 6 log10 reduction of Geobacillus stearothermophilus spores at every inoculation site of each duodenoscope tested, in less than half the exposure time of the standard cycle. The successful outcome of the additional efficacy testing reported here indicates that the SYSTEM 1E(®) is an effective low-temperature liquid chemical sterilization method for duodenoscopes and other critical and semicritical devices. It offers a fast, safe, convenient processing alternative while providing the assurance of a system expressly tested and cleared to achieve liquid chemical sterilization of specific validated duodenoscope models. Copyright © 2016 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

Chemical sensor system

DOEpatents

Darrow, Christopher B.; Satcher, Jr., Joe H.; Lane, Stephen M.; Lee, Abraham P.; Wang, Amy W.

2002-01-01

An implantable chemical sensor system for medical applications is described which permits selective recognition of an analyte using an expandable biocompatible sensor, such as a polymer, that undergoes a dimensional change in the presence of the analyte. The expandable polymer is incorporated into an electronic circuit component that changes its properties (e.g., frequency) when the polymer changes dimension. As the circuit changes its characteristics, an external interrogator transmits a signal transdermally to the transducer, and the concentration of the analyte is determined from the measured changes in the circuit. This invention may be used for minimally invasive monitoring of blood glucose levels in diabetic patients.

Compact chemical energy system for seismic applications

DOEpatents

Engelke, Raymond P.; Hedges, Robert O.; Kammerman, Alan B.; Albright, James N.

1998-01-01

A chemical energy system is formed for producing detonations in a confined environment. An explosive mixture is formed from nitromethane (NM) and diethylenetriamine (DETA). A slapper detonator is arranged adjacent to the explosive mixture to initiate detonation of the mixture. NM and DETA are not classified as explosives when handled separately and can be safely transported and handled by workers in the field. In one aspect of the present invention, the chemicals are mixed at a location where an explosion is to occur. For application in a confined environment, the chemicals are mixed in an inflatable container to minimize storage space until it is desired to initiate an explosion. To enable an inflatable container to be used, at least 2.5 wt % DETA is used in the explosive mixture. A barrier is utilized that is formed of a carbon composite material to provide the appropriate barrel geometry and energy transmission to the explosive mixture from the slapper detonator system.

Mechanical-chemical analyses and sub-chronic systemic toxicity of chemical treated organic bovine bone.

PubMed

Lee, Kwang-il; Lee, Jung-soo; Lee, Keun-soo; Jung, Hong-hee; Ahn, Chan-min; Kim, Young-sik; Shim, Young-bock; Jang, Ju-woong

2015-12-01

Sequentially chemical-treated bovine bone was not only evaluated by mechanical and chemical analyses but also implanted into the gluteal muscles of rats for 12 weeks to investigate potential local pathological effects and systemic toxicities. The test (chemical treated bone) and control (heat treated bone) materials were compared using scanning electron microscope (SEM), x-ray diffraction pattern, inductively coupled plasma analysis, and bending strength test. In the SEM images, the micro-porous structure of heat-treated bone was changed to sintered ceramic-like structure. The structure of bone mineral from test and control materials was analyzed as100% hydroxyapatite. The ratio of calcium (Ca) to potassium (P), the main inorganic elements, was same even though the Ca and P percentages of the control material was relatively higher than the test material. No death or critical symptoms arose from implantation of the test (chemical treated bone) and control (physiological saline) materials during 12 weeks. The implanted sites were macroscopically examined, with all the groups showing non-irritant results. Our results indicate that chemical processed bovine bone has a better mechanical property than the heat treated bone and the implantation of this material does not produce systemic or pathological toxicity. Copyright © 2015 Elsevier Inc. All rights reserved.

Space transfer concepts and analysis for exploration missions. Implementation plan and element description document (draft final). Volume 6: Lunar systems

NASA Technical Reports Server (NTRS)

1991-01-01

NASA's two Office of Space Flight (Code M) Space Transfer Vehicle (STV) contractors supported development of Space Exploration Initiative (SEI) lunar transportation concepts. This work treated lunar SEI missions as the far end of a more near-term STV program, most of whose missions were satellite delivery and servicing requirements derived from Civil Needs Data Base (CNDB) projections. Space Transfer Concepts and Analysis for Exploration Missions (STCAEM) began to address the complete design of a lunar transportation system. The following challenges were addressed: (1) the geometry of aerobraking; (2) accommodation of mixed payloads; (3) cryogenic propellant transfer in Low Lunar Orbit (LLO); (4) fully re-usable design; and (5) growth capability. The leveled requirements, derived requirements, and assumptions applied to the lunar transportation system design are discussed. The mission operations section includes data on mission analysis studies and performance parametrics as well as the operating modes and performance evaluations which include the STCAEM recommendations. Element descriptions for the lunar transportation family included are a listing of the lunar transfer vehicle/lunar excursion vehicle (LTV/LEV) components; trade studies and mass analyses of the transfer and excursion modules; advanced crew recovery vehicle (ACRV) (modified crew recovery vehicle (MCRV)) modifications required to fulfill lunar operations; the aerobrake shape and L/D to be used; and some costing methods and results. Commonality and evolution issues are also discussed.

Vacuum Ultraviolet Photoionization of Complex Chemical Systems

DOE PAGES

Kostko, Oleg; Bandyopadhyay, Biswajit; Ahmed, Musahid

2016-02-24

Tunable vacuum ultraviolet (VUV) radiation coupled to mass spectrometry is applied to the study of complex chemical systems in this paper. The identification of novel reactive intermediates and radicals is revealed in flame, pulsed photolysis, and pyrolysis reactors, leading to the elucidation of spectroscopy, reaction mechanisms, and kinetics. Mass-resolved threshold photoelectron photoion coincidence measurements provide unprecedented access to vibrationally resolved spectra of free radicals present in high-temperature reactors. Photoionization measurements in water clusters, nucleic acid base dimers, and their complexes with water provide signatures of proton transfer in hydrogen-bonded and π-stacked systems. Experimental and theoretical methods to track ion–molecule reactionsmore » and fragmentation pathways in intermolecular and intramolecular hydrogen-bonded systems in sugars and alcohols are described. Photoionization of laser-ablated molecules, clusters, and their reaction products inform thermodynamics and spectroscopy that are relevant to astrochemistry and catalysis. Finally, new directions in coupling VUV radiation to interrogate complex chemical systems are discussed.« less

Nonequilibrium effects on the aerothermodynamics of transatmospheric and aerobraking vehicles

NASA Technical Reports Server (NTRS)

Hassan, Basil; Candler, Graham V.

1993-01-01

A 3D CFD algorithm is used to study the effect of thermal and chemical nonequilibrium on slender and blunt body aerothermodynamics. Both perfect gas and reacting gas air models are used to compute the flow over a generic transatmospheric vehicle and a proposed lunar transfer vehicle. The reacting air is characterized by a translational-rotational temperature and a vibrational-electron-electronic temperature and includes eight chemical species. The effects of chemical reaction, vibrational excitation, and ionization on lift-to-drag ratio and trim angle are investigated. Results for the NASA Ames All-body Configuration show a significant difference in center of gravity location for a reacting gas flight case when compared to a perfect gas wind tunnel case at the same Mach number, Reynolds number, and angle of attack. For the same center of gravity location, the wind tunnel model trims at lower angle of attack than the full-scale flight case. Nonionized and ionized results for a proposed lunar transfer vehicle compare well to computational results obtained from a previously validated reacting gas algorithm. Under the conditions investigated, effects of weak ionization on the heat transfer and aerodynamic coefficients were minimal.

Introducing DAE Systems in Undergraduate and Graduate Chemical Engineering Curriculum

ERIC Educational Resources Information Center

Mandela, Ravi Kumar; Sridhar, L. N.; Rengaswamy, Raghunathan

2010-01-01

Models play an important role in understanding chemical engineering systems. While differential equation models are taught in standard modeling and control courses, Differential Algebraic Equation (DAE) system models are not usually introduced. These models appear naturally in several chemical engineering problems. In this paper, the introduction…

Development of a persistent chemical agent simulation system

NASA Technical Reports Server (NTRS)

1983-01-01

A Persistent Chemical Agent Simulation System was developed (PCASS) to simulate, for force-on-force training exercises, the field environment produced by the presence of persistent chemical agents. Such a simulant system must satisfy several requirements to be of value as a training aid. Specifically, it must provide for realistic training which will generate competency in at least the following areas: (1) detection of the persistent agent presence; (2) proper use of protective equipment and procedures; (3) determination of the extent of contamination; and (4) decontamination of equipment and personnel.

A PROPOSED CHEMICAL INFORMATION AND DATA SYSTEM. VOLUME I.

DTIC Science & Technology

CHEMICAL COMPOUNDS, *DATA PROCESSING, *INFORMATION RETRIEVAL, * CHEMICAL ANALYSIS, INPUT OUTPUT DEVICES, COMPUTER PROGRAMMING, CLASSIFICATION...CONFIGURATIONS, DATA STORAGE SYSTEMS, ATOMS, MOLECULES, PERFORMANCE( ENGINEERING ), MAINTENANCE, SUBJECT INDEXING, MAGNETIC TAPE, AUTOMATIC, MILITARY REQUIREMENTS, TYPEWRITERS, OPTICS, TOPOLOGY, STATISTICAL ANALYSIS, FLOW CHARTING.

The Theory of Thermodynamics for Chemical Reactions in Dispersed Heterogeneous Systems

PubMed

Yongqiang; Baojiao; Jianfeng

1997-07-01

In this paper, the expressions of Gibbs energy change, enthalpy change, entropy change, and equilibrium constant for chemical reactions in dispersed heterogeneous systems are derived using classical thermodynamics theory. The thermodynamical relations for the same reaction system between the dispersed and the block state are also derived. The effects of degree of dispersion on thermodynamical properties, reaction directions, and chemical equilibria are discussed. The results show that the present equation of thermodynamics for chemical reactions is only a special case of the above-mentioned formulas and that the effect of the dispersity of a heterogeneous system on the chemical reaction obeys the Le Chatelier principle of movement of equilibria.

KENNEDY SPACE CENTER, FLA. - While Jay Beason (left), with United Space Alliance, looks on, Jeremy Schwarz (front) and Tom Summers (behind), also with USA, place new tiles on the heat shield of main engine 1 for the orbiter Discovery. A heat shield is a protective layer on a spacecraft designed to protect it from the high temperatures, usually those that result from aerobraking during reentry into the Earth’s atmosphere.

NASA Image and Video Library

2003-09-23

KENNEDY SPACE CENTER, FLA. - While Jay Beason (left), with United Space Alliance, looks on, Jeremy Schwarz (front) and Tom Summers (behind), also with USA, place new tiles on the heat shield of main engine 1 for the orbiter Discovery. A heat shield is a protective layer on a spacecraft designed to protect it from the high temperatures, usually those that result from aerobraking during reentry into the Earth’s atmosphere.

Chemical evolution: A solar system perspective

NASA Technical Reports Server (NTRS)

Oro, J.

1989-01-01

During the last three decades major advances were made in the understanding of the formation of carbon compounds in the universe and of the occurrence of processes of chemical evolution in the solar system and beyond. This was made possible by the development of new astronomical techniques and by the exploration of the solar system by means of properly instrumented spacecraft. Some of the major findings made as a result of these observations are summarized.

Micro Thermal and Chemical Systems for In Situ Resource Utilization on Mars

NASA Technical Reports Server (NTRS)

Wegeng, Robert S.; Sanders, Gerald

2000-01-01

Robotic sample return missions and postulated human missions to Mars can be greatly aided through the development and utilization of compact chemical processing systems that process atmospheric gases and other indigenous resources to produce hydrocarbon propellants/fuels, oxygen, and other needed chemicals. When used to reduce earth launch mass, substantial cost savings can result. Process Intensification and Process Miniaturization can simultaneously be achieved through the application of microfabricated chemical process systems, based on the rapid heat and mass transport in engineered microchannels. Researchers at NASA's Johnson Space Center (JSC) and the Department of Energy's Pacific Northwest National Laboratory (PNNL) are collaboratively developing micro thermal and chemical systems for NASA's Mission to Mars program. Preliminary results show that many standard chemical process components (e.g., heat exchangers, chemical reactors and chemical separations units) can be reduced in hardware volume without a corresponding reduction in chemical production rates. Low pressure drops are also achievable when appropriate scaling rules are applied. This paper will discuss current progress in the development of engineered microchemical systems for space and terrestrial applications, including fabrication methods, expected operating characteristics, and specific experimental results.

CD-REST: a system for extracting chemical-induced disease relation in literature.

PubMed

Xu, Jun; Wu, Yonghui; Zhang, Yaoyun; Wang, Jingqi; Lee, Hee-Jin; Xu, Hua

2016-01-01

Mining chemical-induced disease relations embedded in the vast biomedical literature could facilitate a wide range of computational biomedical applications, such as pharmacovigilance. The BioCreative V organized a Chemical Disease Relation (CDR) Track regarding chemical-induced disease relation extraction from biomedical literature in 2015. We participated in all subtasks of this challenge. In this article, we present our participation system Chemical Disease Relation Extraction SysTem (CD-REST), an end-to-end system for extracting chemical-induced disease relations in biomedical literature. CD-REST consists of two main components: (1) a chemical and disease named entity recognition and normalization module, which employs the Conditional Random Fields algorithm for entity recognition and a Vector Space Model-based approach for normalization; and (2) a relation extraction module that classifies both sentence-level and document-level candidate drug-disease pairs by support vector machines. Our system achieved the best performance on the chemical-induced disease relation extraction subtask in the BioCreative V CDR Track, demonstrating the effectiveness of our proposed machine learning-based approaches for automatic extraction of chemical-induced disease relations in biomedical literature. The CD-REST system provides web services using HTTP POST request. The web services can be accessed fromhttp://clinicalnlptool.com/cdr The online CD-REST demonstration system is available athttp://clinicalnlptool.com/cdr/cdr.html. Database URL:http://clinicalnlptool.com/cdr;http://clinicalnlptool.com/cdr/cdr.html. © The Author(s) 2016. Published by Oxford University Press.

Combustion flame-plasma hybrid reactor systems, and chemical reactant sources

DOEpatents

Kong, Peter C

2013-11-26

Combustion flame-plasma hybrid reactor systems, chemical reactant sources, and related methods are disclosed. In one embodiment, a combustion flame-plasma hybrid reactor system comprising a reaction chamber, a combustion torch positioned to direct a flame into the reaction chamber, and one or more reactant feed assemblies configured to electrically energize at least one electrically conductive solid reactant structure to form a plasma and feed each electrically conductive solid reactant structure into the plasma to form at least one product is disclosed. In an additional embodiment, a chemical reactant source for a combustion flame-plasma hybrid reactor comprising an elongated electrically conductive reactant structure consisting essentially of at least one chemical reactant is disclosed. In further embodiments, methods of forming a chemical reactant source and methods of chemically converting at least one reactant into at least one product are disclosed.

Reconfigurable all-dielectric metasurface based on tunable chemical systems in aqueous solution.

PubMed

Yang, Xiaoqing; Zhang, Di; Wu, Shiyue; Yin, Yang; Li, Lanshuo; Cao, Kaiyuan; Huang, Kama

2017-06-09

Dynamic control transmission and polarization properties of electromagnetic (EM) wave propagation is investigated using chemical reconfigurable all-dielectric metasurface. The metasurface is composed of cross-shaped periodical teflon tubes and inner filled chemical systems (i.e., mixtures and chemical reaction) in aqueous solution. By tuning the complex permittivity of chemical systems, the reconfigurable metasurface can be easily achieved. The transmission properties of different incident polarized waves (i.e., linear and circular polarization) were simulated and experimentally measured for static ethanol solution as volume ratio changed. Both results indicated this metasurface can serve as either tunable FSS (Frequency Selective Surface) or tunable linear-to-circular/cross Polarization Converter at required frequency range. Based on the reconfigurable laws obtained from static solutions, we developed a dynamic dielectric system and researched a typical chemical reaction with time-varying permittivity filled in the tubes experimentally. It provides new ways for realizing automatic reconfiguration of metasurface by chemical reaction system with given variation laws of permittivity.

Data acquisition system for chemical kinetic studies

PubMed Central

Zhu, Yu-zhen; Zhou, Xin; Zang, Xiang-sheng

1989-01-01

A microcomputer-interfaced data acquisition system for chemical kinetics (interfacing with laboratory analogue instruments) has been developed. Analogue signals from instruments used in kinetics experiments are amplifed by a wide-range adjustable high-gain operational amplifier and smoothed by an op-based filter, and then digitized at rates of up to 104 samples per channel by an ADC 0816 digitizer. The ADC data transfer and manipulation routine was written in Assembler code and in high-level language; the graphics package and data treatment package is in Basic. For the various sampling speeds, all of the program can be written using Basic-Assembler or completely in Assembler if a high sampling rate is needed. Several numerical treatment methods for chemical kinetics have been utilized to smooth the data from experiments. The computer-interfaced system for second-order chemical kinetic studies was applied to the determination of the rate constant of the saponification of ethyl acetate at 35°C. For this specific problem, an averaging treatment was used which can be called an interval method. The use of this method avoids the diffcully of measuring the starting time of the reaction. Two groups of experimental data and results were used to evaluate the systems performance. All of the results obtained are in agreement with the reference value. PMID:18925219

Endocrine Disrupting Chemical Impacts on Aquatic Systems

NASA Astrophysics Data System (ADS)

Jobling, Susan

2014-07-01

We often talk about the importance of water, but one area that's often overlooked is the safety of our water supply. How many people actually think about the purity of their water when they turn on the tap? We may have real reason to be concerned because our water delivery systems and treatment technology seem to be stuck in the past, relying on old water treatment and water delivery systems. While these systems still do a great job filtering out particles, parasites and bacteria, they usually fail to remove 21st century contaminants like pesticides, industrial chemicals, lead, pharmaceuticals and arsenic. Indeed our water contains already a whole plethora of things in daily commerce and pharmaceuticals are increasingly showing up in the water supply, including antibiotics, anti-convulsants, mood altering medications and sex hormones. As the world's dependence on chemicals grows, our water supplies will continue to feel the effects, which inevitably will touch every person on this planet...

Chemical combination effects predict connectivity in biological systems

PubMed Central

Lehár, Joseph; Zimmermann, Grant R; Krueger, Andrew S; Molnar, Raymond A; Ledell, Jebediah T; Heilbut, Adrian M; Short, Glenn F; Giusti, Leanne C; Nolan, Garry P; Magid, Omar A; Lee, Margaret S; Borisy, Alexis A; Stockwell, Brent R; Keith, Curtis T

2007-01-01

Efforts to construct therapeutically useful models of biological systems require large and diverse sets of data on functional connections between their components. Here we show that cellular responses to combinations of chemicals reveal how their biological targets are connected. Simulations of pathways with pairs of inhibitors at varying doses predict distinct response surface shapes that are reproduced in a yeast experiment, with further support from a larger screen using human tumour cells. The response morphology yields detailed connectivity constraints between nearby targets, and synergy profiles across many combinations show relatedness between targets in the whole network. Constraints from chemical combinations complement genetic studies, because they probe different cellular components and can be applied to disease models that are not amenable to mutagenesis. Chemical probes also offer increased flexibility, as they can be continuously dosed, temporally controlled, and readily combined. After extending this initial study to cover a wider range of combination effects and pathway topologies, chemical combinations may be used to refine network models or to identify novel targets. This response surface methodology may even apply to non-biological systems where responses to targeted perturbations can be measured. PMID:17332758

SSTAC/ARTS review of the draft Integrated Technology Plan (ITP). Volume 8: Aerothermodynamics Automation and Robotics (A/R) systems sensors, high-temperature superconductivity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

Viewgraphs of briefings presented at the SSTAC/ARTS review of the draft Integrated Technology Plan (ITP) on aerothermodynamics, automation and robotics systems, sensors, and high-temperature superconductivity are included. Topics covered include: aerothermodynamics; aerobraking; aeroassist flight experiment; entry technology for probes and penetrators; automation and robotics; artificial intelligence; NASA telerobotics program; planetary rover program; science sensor technology; direct detector; submillimeter sensors; laser sensors; passive microwave sensing; active microwave sensing; sensor electronics; sensor optics; coolers and cryogenics; and high temperature superconductivity.

SSTAC/ARTS review of the draft Integrated Technology Plan (ITP). Volume 8: Aerothermodynamics Automation and Robotics (A/R) systems sensors, high-temperature superconductivity

NASA Technical Reports Server (NTRS)

1991-01-01

Viewgraphs of briefings presented at the SSTAC/ARTS review of the draft Integrated Technology Plan (ITP) on aerothermodynamics, automation and robotics systems, sensors, and high-temperature superconductivity are included. Topics covered include: aerothermodynamics; aerobraking; aeroassist flight experiment; entry technology for probes and penetrators; automation and robotics; artificial intelligence; NASA telerobotics program; planetary rover program; science sensor technology; direct detector; submillimeter sensors; laser sensors; passive microwave sensing; active microwave sensing; sensor electronics; sensor optics; coolers and cryogenics; and high temperature superconductivity.

Development of a Communication System Compatible with Chemical Protective Clothing and Equipment.

DTIC Science & Technology

1986-06-23

for the Chemical Protective Clothing Communication System are discussed in the operation manuals for the engineering prototypes of the trans- ceiver...Report Date DEVELOPMENT OF A COMMUNICATION SYSTEM COMPATIBLE June 1986 WITH CHEMICAL PROTECTIVE CLOTHING AND EQUIPMENT 6. Performing Organization Code 8...Abstract - ’The U. S. Coast Guard and NASA joined in a project to develop a cominications system to operate inside protective suits used in chemical spill

Implementation of an Online Database for Chemical Propulsion Systems

NASA Technical Reports Server (NTRS)

David B. Owen, II; McRight, Patrick S.; Cardiff, Eric H.

2009-01-01

The Johns Hopkins University, Chemical Propulsion Information Analysis Center (CPIAC) has been working closely with NASA Goddard Space Flight Center (GSFC); NASA Marshall Space Flight Center (MSFC); the University of Alabama at Huntsville (UAH); The Johns Hopkins University, Applied Physics Laboratory (APL); and NASA Jet Propulsion Laboratory (JPL) to capture satellite and spacecraft propulsion system information for an online database tool. The Spacecraft Chemical Propulsion Database (SCPD) is a new online central repository containing general and detailed system and component information on a variety of spacecraft propulsion systems. This paper only uses data that have been approved for public release with unlimited distribution. The data, supporting documentation, and ability to produce reports on demand, enable a researcher using SCPD to compare spacecraft easily, generate information for trade studies and mass estimates, and learn from the experiences of others through what has already been done. This paper outlines the layout and advantages of SCPD, including a simple example application with a few chemical propulsion systems from various NASA spacecraft.

Plasma Assisted ISRU at Mars

NASA Technical Reports Server (NTRS)

Moses, Robert W.; Kuhl, Christopher A.; Templeton, Justin D.

2005-01-01

NASA's exploration goals for Mars and Beyond will require new power systems and in situ resource utilization (ISRU) technologies. Regenerative aerobraking may offer a revolutionary approach for in situ power generation and oxygen harvesting during these exploration missions. In theory, power and oxygen can be collected during aerobraking and stored for later use in orbit or on the planet. This technology would capture energy and oxygen from the plasma field that occurs naturally during hypersonic entry using well understood principles of magnetohydrodynamics and oxygen filtration. This innovative approach generates resources upon arrival at the operational site, and thus greatly differs from the traditional approach of taking everything you need with you from Earth. Fundamental analysis, computational fluid dynamics, and some testing of experimental hardware have established the basic feasibility of generating power during a Mars entry. Oxygen filtration at conditions consistent with spacecraft entry parameters at Mars has been studied to a lesser extent. Other uses of the MHD power are presented. This paper illustrates how some features of regenerative aerobraking may be applied to support human and robotic missions at Mars.

Electronic energy density in chemical reaction systems

NASA Astrophysics Data System (ADS)

Tachibana, Akitomo

2001-08-01

The energy of chemical reaction is visualized in real space using the electronic energy density nE(r⃗) associated with the electron density n(r⃗). The electronic energy density nE(r⃗) is decomposed into the kinetic energy density nT(r⃗), the external potential energy density nV(r⃗), and the interelectron potential energy density nW(r⃗). Using the electronic energy density nE(r⃗) we can pick up any point in a chemical reaction system and find how the electronic energy E is assigned to the selected point. We can then integrate the electronic energy density nE(r⃗) in any region R surrounding the point and find out the regional electronic energy ER to the global E. The kinetic energy density nT(r⃗) is used to identify the intrinsic shape of the reactants, the electronic transition state, and the reaction products along the course of the chemical reaction coordinate. The intrinsic shape is identified with the electronic interface S that discriminates the region RD of the electronic drop from the region RA of the electronic atmosphere in the density distribution of the electron gas. If the R spans the whole space, then the integral gives the total E. The regional electronic energy ER in thermodynamic ensemble is realized in electrochemistry as the intrinsic Volta electric potential φR and the intrinsic Herring-Nichols work function ΦR. We have picked up first a hydrogen-like atom for which we have analytical exact expressions of the relativistic kinetic energy density nTM(r⃗) and its nonrelativistic version nT(r⃗). These expressions are valid for any excited bound states as well as the ground state. Second, we have selected the following five reaction systems and show the figures of the nT(r⃗) as well as the other energy densities along the intrinsic reaction coordinates: a protonation reaction to He, addition reactions of HF to C2H4 and C2H2, hydrogen abstraction reactions of NH3+ from HF and NH3. Valence electrons possess their unique

CMOS-MEMS Chemiresistive and Chemicapacitive Chemical Sensor System

NASA Astrophysics Data System (ADS)

Lazarus, Nathan S.

Integrating chemical sensors with testing electronics is a powerful technique with the potential to lower power and cost and allow for lower system limits of detection. This thesis explores the possibility of creating an integrated sensor system intended to be embedded within respirator cartridges to notify the user that hazardous chemicals will soon leak into the face mask. For a chemical sensor designer, this application is particularly challenging due to the need for a very sensitive and cheap sensor that will be exposed to widely varying environmental conditions during use. An octanethiol-coated gold nanoparticle chemiresistor to detect industrial solvents is developed, focusing on characterizing the environmental stability and limits of detection of the sensor. Since the chemiresistor was found to be highly sensitive to water vapor, a series of highly sensitive humidity sensor topologies were developed, with sensitivities several times previous integrated capacitive humidity sensors achieved. Circuit techniques were then explored to reduce the humidity sensor limits of detection, including the analysis of noise, charge injection, jitter and clock feedthrough in a charge-based capacitance measurement (CBCM) circuit and the design of a low noise Colpitts LC oscillator. The characterization of high resistance gold nanoclusters for capacitive chemical sensing was also performed. In the final section, a preconcentrator, a heater element intended to release a brief concentrated pulse of analate, was developed and tested for the purposes of lowering the system limit of detection.

Computational singular perturbation analysis of stochastic chemical systems with stiffness

NASA Astrophysics Data System (ADS)

Wang, Lijin; Han, Xiaoying; Cao, Yanzhao; Najm, Habib N.

2017-04-01

Computational singular perturbation (CSP) is a useful method for analysis, reduction, and time integration of stiff ordinary differential equation systems. It has found dominant utility, in particular, in chemical reaction systems with a large range of time scales at continuum and deterministic level. On the other hand, CSP is not directly applicable to chemical reaction systems at micro or meso-scale, where stochasticity plays an non-negligible role and thus has to be taken into account. In this work we develop a novel stochastic computational singular perturbation (SCSP) analysis and time integration framework, and associated algorithm, that can be used to not only construct accurately and efficiently the numerical solutions to stiff stochastic chemical reaction systems, but also analyze the dynamics of the reduced stochastic reaction systems. The algorithm is illustrated by an application to a benchmark stochastic differential equation model, and numerical experiments are carried out to demonstrate the effectiveness of the construction.

Computational singular perturbation analysis of stochastic chemical systems with stiffness

DOE PAGES

Wang, Lijin; Han, Xiaoying; Cao, Yanzhao; ...

2017-01-25

Computational singular perturbation (CSP) is a useful method for analysis, reduction, and time integration of stiff ordinary differential equation systems. It has found dominant utility, in particular, in chemical reaction systems with a large range of time scales at continuum and deterministic level. On the other hand, CSP is not directly applicable to chemical reaction systems at micro or meso-scale, where stochasticity plays an non-negligible role and thus has to be taken into account. In this work we develop a novel stochastic computational singular perturbation (SCSP) analysis and time integration framework, and associated algorithm, that can be used to notmore » only construct accurately and efficiently the numerical solutions to stiff stochastic chemical reaction systems, but also analyze the dynamics of the reduced stochastic reaction systems. Furthermore, the algorithm is illustrated by an application to a benchmark stochastic differential equation model, and numerical experiments are carried out to demonstrate the effectiveness of the construction.« less

Spatiotemporal Coding of Individual Chemicals by the Gustatory System

PubMed Central

Reiter, Sam; Campillo Rodriguez, Chelsey; Sun, Kui

2015-01-01

Four of the five major sensory systems (vision, olfaction, somatosensation, and audition) are thought to use different but partially overlapping sets of neurons to form unique representations of vast numbers of stimuli. The only exception is gustation, which is thought to represent only small numbers of basic taste categories. However, using new methods for delivering tastant chemicals and making electrophysiological recordings from the tractable gustatory system of the moth Manduca sexta, we found chemical-specific information is as follows: (1) initially encoded in the population of gustatory receptor neurons as broadly distributed spatiotemporal patterns of activity; (2) dramatically integrated and temporally transformed as it propagates to monosynaptically connected second-order neurons; and (3) observed in tastant-specific behavior. Our results are consistent with an emerging view of the gustatory system: rather than constructing basic taste categories, it uses a spatiotemporal population code to generate unique neural representations of individual tastant chemicals. SIGNIFICANCE STATEMENT Our results provide a new view of taste processing. Using a new, relatively simple model system and a new set of techniques to deliver taste stimuli and to examine gustatory receptor neurons and their immediate followers, we found no evidence for labeled line connectivity, or basic taste categories such as sweet, salty, bitter, and sour. Rather, individual tastant chemicals are represented as patterns of spiking activity distributed across populations of receptor neurons. These representations are transformed substantially as multiple types of receptor neurons converge upon follower neurons, leading to a combinatorial coding format that uniquely, rapidly, and efficiently represents individual taste chemicals. Finally, we found that the information content of these neurons can drive tastant-specific behavior. PMID:26338341

An Experimental Framework for Generating Evolvable Chemical Systems in the Laboratory

NASA Astrophysics Data System (ADS)

Baum, David A.; Vetsigian, Kalin

2017-12-01

Most experimental work on the origin of life has focused on either characterizing the chemical synthesis of particular biochemicals and their precursors or on designing simple chemical systems that manifest life-like properties such as self-propagation or adaptive evolution. Here we propose a new class of experiments, analogous to artificial ecosystem selection, where we select for spontaneously forming self-propagating chemical assemblages in the lab and then seek evidence of a response to that selection as a key indicator that life-like chemical systems have arisen. Since surfaces and surface metabolism likely played an important role in the origin of life, a key experimental challenge is to find conditions that foster nucleation and spread of chemical consortia on surfaces. We propose high-throughput screening of a diverse set of conditions in order to identify combinations of "food," energy sources, and mineral surfaces that foster the emergence of surface-associated chemical consortia that are capable of adaptive evolution. Identification of such systems would greatly advance our understanding of the emergence of self-propagating entities and the onset of adaptive evolution during the origin of life.

Virtual Exploration of the Ring Systems Chemical Universe.

PubMed

Visini, Ricardo; Arús-Pous, Josep; Awale, Mahendra; Reymond, Jean-Louis

2017-11-27

Here, we explore the chemical space of all virtually possible organic molecules focusing on ring systems, which represent the cyclic cores of organic molecules obtained by removing all acyclic bonds and converting all remaining atoms to carbon. This approach circumvents the combinatorial explosion encountered when enumerating the molecules themselves. We report the chemical universe database GDB4c containing 916 130 ring systems up to four saturated or aromatic rings and maximum ring size of 14 atoms and GDB4c3D containing the corresponding 6 555 929 stereoisomers. Almost all (98.6%) of these ring systems are unknown and represent chiral 3D-shaped macrocycles containing small rings and quaternary centers reminiscent of polycyclic natural products. We envision that GDB4c can serve to select new ring systems from which to design analogs of such natural products. The database is available for download at www.gdb.unibe.ch together with interactive visualization and search tools as a resource for molecular design.

Spatiotemporal Coding of Individual Chemicals by the Gustatory System.

PubMed

Reiter, Sam; Campillo Rodriguez, Chelsey; Sun, Kui; Stopfer, Mark

2015-09-02

Four of the five major sensory systems (vision, olfaction, somatosensation, and audition) are thought to use different but partially overlapping sets of neurons to form unique representations of vast numbers of stimuli. The only exception is gustation, which is thought to represent only small numbers of basic taste categories. However, using new methods for delivering tastant chemicals and making electrophysiological recordings from the tractable gustatory system of the moth Manduca sexta, we found chemical-specific information is as follows: (1) initially encoded in the population of gustatory receptor neurons as broadly distributed spatiotemporal patterns of activity; (2) dramatically integrated and temporally transformed as it propagates to monosynaptically connected second-order neurons; and (3) observed in tastant-specific behavior. Our results are consistent with an emerging view of the gustatory system: rather than constructing basic taste categories, it uses a spatiotemporal population code to generate unique neural representations of individual tastant chemicals. Our results provide a new view of taste processing. Using a new, relatively simple model system and a new set of techniques to deliver taste stimuli and to examine gustatory receptor neurons and their immediate followers, we found no evidence for labeled line connectivity, or basic taste categories such as sweet, salty, bitter, and sour. Rather, individual tastant chemicals are represented as patterns of spiking activity distributed across populations of receptor neurons. These representations are transformed substantially as multiple types of receptor neurons converge upon follower neurons, leading to a combinatorial coding format that uniquely, rapidly, and efficiently represents individual taste chemicals. Finally, we found that the information content of these neurons can drive tastant-specific behavior. Copyright © 2015 the authors 0270-6474/15/3512309-13$15.00/0.

Proceedings of the DOE chemical energy storage and hydrogen energy systems contracts review

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

Sessions were held on electrolysis-based hydrogen storage systems, hydrogen production, hydrogen storage systems, hydrogen storage materials, end-use applications and system studies, chemical heat pump/chemical energy storage systems, systems studies and assessment, thermochemical hydrogen production cycles, advanced production concepts, and containment materials. (LHK)

Versatile Dual Photoresponsive System for Precise Control of Chemical Reactions.

PubMed

Xu, Can; Bing, Wei; Wang, Faming; Ren, Jinsong; Qu, Xiaogang

2017-08-22

A versatile method for photoregulation of chemical reactions was developed through a combination of near-infrared (NIR) and ultraviolet (UV) light sensitive materials. This regulatory effect was achieved through photoresponsive modulation of reaction temperature and pH values, two prominent factors influencing reaction kinetics. Photothermal nanomaterial graphene oxide (GO) and photobase reagent malachite green carbinol base (MGCB) were selected for temperature and pH regulation, respectively. Using nanocatalyst- and enzyme-mediated chemical reactions as model systems, we demonstrated the feasibility and high efficiency of this method. In addition, a photoresponsive, multifunctional "Band-aid"-like hydrogel platform was presented for programmable wound healing. Overall, this simple, efficient, and reversible system was found to be effective for controlling a wide variety of chemical reactions. Our work may provide a method for remote and sustainable control over chemical reactions for industrial and biomedical applications.

Chemical treatment costs reduced with in-pond raceway systems

USDA-ARS?s Scientific Manuscript database

Production systems such as in-pond raceway systems (IPRS) and split ponds are providing an alternative to traditional pond culture for raising catfish in several southeastern states. One advantage noted by farmers utilizing these systems is the reduced cost associated with the chemical treatment of ...

[Development of medical emergency response system for accidents due to chemicals in Chongqing municipality].

PubMed

Ning, Xu; Dong, Zhao-jun; Mu, Ling; Zhai, Jian-cai

2006-12-01

To plan and develop a Chongqing chemical accident rescue command system. Based on the modes of leakage and diffusion of various poisonous gases and chemicals, different modes of injuries produced, and their appropriate rescue and treatments, also taking the following factors such as the condition of storage of chemicals, meteorological and geographic conditions, medical institutions and equipment, and their rescuing capacity into consideration, a plan was drafted to establish the rescue system. Real-time simulation technology, data analysis, evaluation technology and database technology were employed in the planning. Using Visual Studio 6.0 as the software development platform, this project aimed to design the software of an emergency command system for chemical accidents in Chongqing which could be operated with the Windows 2000/XP operating system. This system provided a dynamic scope of the endangered area, casualty number estimates, and recommendation of measures and a rescue plan for various chemical accidents. Furthermore, the system helped retrieve comprehensive information regarding the physical and chemical characteristics of more than 4 200 dangerous poisonous chemicals and their appropriate treatment modalities. This system is easy to operate with a friendly interface, functions rapidly and can provide real-time analysis with comparatively precise results. This system could satisfy the requirements of executing the command and the rescue of a chemical accident with good prospects of application.

Thermocouple-based Temperature Sensing System for Chemical Cell Inside Micro UAV Device

NASA Astrophysics Data System (ADS)

Han, Yanhui; Feng, Yue; Lou, Haozhe; Zhang, Xinzhao

2018-03-01

Environmental temperature of UAV system is crucial for chemical cell component inside. Once the temperature of this chemical cell is over 259 °C and keeps more than 20 min, the high thermal accumulation would result in an explosion, which seriously damage the whole UAV system. Therefore, we develop a micro temperature sensing system for monitoring the temperature of chemical cell thermally influenced by UAV device deployed in a 300 °C temperature environment, which is quite useful for insensitive munitions and UAV safety enhancement technologies.

Insect-gene-activity detection system for chemical and biological warfare agents and toxic industrial chemicals

NASA Astrophysics Data System (ADS)

Mackie, Ryan S.; Schilling, Amanda S.; Lopez, Arturo M.; Rayms-Keller, Alfredo

2002-02-01

Detection of multiple chemical and biological weapons (CBW) agents and/or complex mixtures of toxic industrial chemicals (TIC) is imperative for both the commercial and military sectors. In a military scenario, a multi-CBW attack would create confusion, thereby delaying decontamination and therapeutic efforts. In the commercial sector, polluted sites invariably contain a mixture of TIC. Novel detection systems capable of detecting CBW and TIC are sorely needed. While it may be impossible to build a detector capable of discriminating all the possible combinations of CBW, a detection system capable of statistically predicting the most likely composition of a given mixture is within the reach of current emerging technologies. Aquatic insect-gene activity may prove to be a sensitive, discriminating, and elegant paradigm for the detection of CBW and TIC. We propose to systematically establish the expression patterns of selected protein markers in insects exposed to specific mixtures of chemical and biological warfare agents to generate a library of biosignatures of exposure. The predicting capabilities of an operational library of biosignatures of exposures will allow the detection of emerging novel or genetically engineered agents, as well as complex mixtures of chemical and biological weapons agents. CBW and TIC are discussed in the context of war, terrorism, and pollution.

Improvement of a Chemical Storage Room Ventilation System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yousif, Emad; Al-Dahhan, Wedad; Abed, Rashed Nema

Scientists at universities across Iraq are actively working to report actual incidents and accidents occurring in their laboratories, as well as structural improvements made to improve safety and security, to raise awareness and encourage openness, leading to widespread adoption of robust Chemical Safety and Security (CSS) practices. This manuscript is the third in a series of five case studies describing laboratory incidents, accidents, and laboratory improvements. We summarize an improvement to the chemical storage room ventilation system at Al-Nahrain University to create and maintain a safe working atmosphere in an area where chemicals are stored and handled, using US andmore » European design practices, standards, and regulations.« less

A rule-based expert system for chemical prioritization using effects-based chemical categories

EPA Science Inventory

A rule-based expert system (ES) was developed to predict chemical binding to the estrogen receptor (ER) patterned on the research approaches championed by Gilman Veith to whom this article and journal issue are dedicated. The ERES was built to be mechanistically-transparent and m...

Self-regulating chemo-mechano-chemical systems

DOEpatents

Aizenberg, Joanna; He, Ximin; Aizenberg, Michael

2017-05-16

A chemo-mechano-chemical (C.sub.1-M-C.sub.2) system includes a base supporting an actuatable structure, said structure comprising a functionalized portion and being embedded in an environmentally responsive gel capable of volume change in response to an environmental stimulus; a first fluid layer disposed over the base and in contact with the actuatable structure, said first fluid layer comprising the environmentally responsive gel; and a second fluid layer in contact with the actuatable structure, wherein the layers are positioned such that the functionalized portion is in contact with the second layer in a first relaxed state and in contact with the first layer in a second actuated state and wherein the functionalized portion interacts with at least one of the layers to provide a chemical or physical response.

Design of a Ram Accelerator mass launch system

NASA Technical Reports Server (NTRS)

1988-01-01

The Ram Accelerator, a chemically propelled, impulsive mass launch system, is presented as a viable concept for directly launching acceleration-insensitive payloads into low Earth orbit. The principles of propulsion are based on those of an airbreathing supersonic ramjet. The payload vehicle acts as the ramjet centerbody and travels through a fixed launch tube that acts as the ramjet outer cowling. The launch tube is filled with premixed gaseous fuel and oxidizer mixtures that combust at the base of the vehicle and produce thrust. Two modes of in-tube propulsion involving ramjet cycles are used in sequence to accelerate the vehicle from 0.7 km/sec to 9 km/sec. Requirements for placing a 2000 kg vehicle into a 500-km circular orbit, with a minimum amount of onboard rocket propellant for orbital maneuvers, are examined. It is shown that in-tube propulsion requirements dictate a launch tube length of 5.1 km to achieve an exit velocity of 9 km/sec, with peak accelerations not to exceed 1000 g's. Aerodynamic heating due to atmospheric transit requires minimal ablative protection and the vehicle retains a large percentage of its exit velocity. An indirect orbital insertion maneuver with aerobraking and two apogee burns is examined to minimize the required onboard propellant mass. An appropriate onboard propulsion system design to perform the required orbital maneuvers with minimum mass requirements is also determined. The structural designs of both the launch tube and the payload vehicle are examined using simple structural and finite element analysis for various materials.

Propagating Molecular Recognition Events through Highly Integrated Sense-Response Chemical Systems

DTIC Science & Technology

2017-08-01

Propagating Molecular Recognition Events through Highly Integrated Sense-Response Chemical Systems The views, opinions and/or findings contained in...University of California - San Diego Title: Propagating Molecular Recognition Events through Highly Integrated Sense-Response Chemical Systems Report Term...including enzymatic reactions , occurring at the aqueous interfaces of thermotropic LCs show promise as the basis of biomolecular triggers of LC

COMPUTER SUPPORT SYSTEMS FOR ESTIMATING CHEMICAL TOXICITY: PRESENT CAPABILITIES AND FUTURE TRENDS

EPA Science Inventory

Computer Support Systems for Estimating Chemical Toxicity: Present Capabilities and Future Trends

A wide variety of computer-based artificial intelligence (AI) and decision support systems exist currently to aid in the assessment of toxicity for environmental chemicals. T...

Chemical compositions of primitive solar system particles

NASA Technical Reports Server (NTRS)

Sutton, Steve R.; Bajt, S.

1994-01-01

Chemical studies of micrometeorites are of fundamental importance primarily because atmospheric entry selection effects (such as destruction of friable objects) are less significant than those for conventional meteorites. As a result, particles that have experienced very little postaccretional processing have a significant chance of surviving the Earth encounter and subsequent collection. Thus, chemical analyses of these relatively unaltered micrometeorites may lead to a better understanding of the compositions of the most primitive materials in the solar system and thereby constrain the conditions (physical and chemical) that existed in the early solar nebula. Micrometeorites have been collected from the stratosphere, polar ices, and ocean sediments, but the stratospheric collection is the best source for the most unaltered material because they are small and are not heated to their melting points. Despite the fact that the stratospheric micrometeorites have masses in the nanogram range, a variety of microanalytical techniques have been applied to bulk chemical analyses with part-per-million sensitivity. In some cases, multi-disciplinary studies (e.g., chemistry and mineralogy) have been performed on individual particles. The first-order conclusion is that the chondrite-like particles are chemically similar to carbonaceous chondrites but in detail are distinct from members of the conventional meteorite collection. The purpose of this paper is to provide an overview of the results to date and identify important areas for further study.

Formal modeling of a system of chemical reactions under uncertainty.

PubMed

Ghosh, Krishnendu; Schlipf, John

2014-10-01

We describe a novel formalism representing a system of chemical reactions, with imprecise rates of reactions and concentrations of chemicals, and describe a model reduction method, pruning, based on the chemical properties. We present two algorithms, midpoint approximation and interval approximation, for construction of efficient model abstractions with uncertainty in data. We evaluate computational feasibility by posing queries in computation tree logic (CTL) on a prototype of extracellular-signal-regulated kinase (ERK) pathway.

Wireless chemical sensor system based on electromagnetically energy-harvesting metamaterials (Conference Presentation)

NASA Astrophysics Data System (ADS)

Lee, Wonwoo; Jung, Yonghee; Jung, Hyunseung; Lee, Hojin

2017-02-01

In the past decade, there have been many studies on metamaterial based chemical and biological sensors due to their exotic resonance properties in microwave ranges. However, in spite of their non-destructive and highly sensitive properties, they have suffered from the use of bulky and expensive external measurement systems like a network analyzer for measuring resonance properties in the microwave regime. In this study, to increase accessibility of the metamaterial-based sensors, we propose a novel wireless chemical sensor system based on energy harvesting metamaterials at the microwave frequencies. The proposed metamaterial chemical sensor consists of a single split ring resonator and rectifier circuit to harvest the energy at the specific frequency, so that the chemical composition of the specific solution can be distinguished by the proposed metamaterial sensor by using the resonance property between the source antenna and the metamaterial which induces the variation in the energy harvesting rate of our sensor system. In our experimental setup, we used a 2.4 GHz Wi-Fi system as a source antenna. To verify the chemical sensitivity of the proposed sensor intuitively, we adopted a light emitting diode as an indicator of which luminescence is proportional to the energy harvesting rate determined by the ratio of ethanol and water in their binary mixture. With these results, it can be expected that our metamaterial-based wireless sensor can pave the way to the miniaturized wireless sensor systems and can be applied to not only for the chemical fluidic sensors but also for other dynamic environment sensing systems.

An expert system for prediction of chemical toxicity

USGS Publications Warehouse

Hickey, James P.; Aldridge, Andrew J.; Passino-Reader, Dora R.; Frank, Anthony M.

1992-01-01

The National Fisheries Research Center- Great Lakes has developed an interactive computer program that uses the structure of an organic molecule to predict its acute toxicity to four aquatic species. The expert system software, written in the muLISP language, identifies the skeletal structures and substituent groups of an organic molecule from a user-supplied standard chemical notation known as a SMILES string, and then generates values for four solvatochromic parameters. Multiple regression equations relate these parameters to the toxicities (expressed as log10LC50s and log10EC50s, along with 95% confidence intervals) for four species. The system is demonstrated by prediction of toxicity for anilide-type pesticides to the fathead minnow (Pimephales promelas). This software is designed for use on an IBM-compatible personal computer by personnel with minimal toxicology background for rapid estimation of chemical toxicity. The system has numerous applications, with much potential for use in the pharmaceutical industry

Concept for A Mission to Titan, Saturn System and Enceladus

NASA Astrophysics Data System (ADS)

Beauchamp, Patricia; Reh, K. R.; Lunine, J.; Coustenis, A.; Erd, C.; Matson, D.; Lebreton, J.

2008-09-01

A mission to Titan is a high priority for exploration, as recommended by the 2003 NRC report on New Frontiers in the Solar System (Decadal Survey). As anticipated by the NRC subcommittee, recent Cassini-Huygens discoveries have revolutionized our understanding of Titan and its potential for harbouring "ingredients” necessary for life. These discoveries reveal that Titan is rich in organics, possibly contains a vast subsurface ocean and has energy sources to drive chemical evolution. With these recent discoveries, interest in Titan as the next scientific target in the outer Solar System is strongly reinforced. Cassini's discovery of active geysers on Enceladus adds a second target in the Saturn system for such a mission, one that is synergistic with Titan in understanding planetary evolution and in adding a potential abode in the Saturn system for life. The TSSM concept would consist of a NASA provided orbiter with ESA provided Lander and Montgolfiere Balloon. The mission would launch on an Atlas 551 in 2018-2020, and travel to Saturn on a gravity assist trajectory, reaching Saturn 8.5 years later. The SEP stage would be released and the main engine would place the flight system into orbit around Saturn for a 2 year tour. During the first Titan flyby the in situ elements would be released to target a polar lake and mid-latitude region respectively. During the tour phase, TSSM would accomplish Saturn system and Enceladus science. Following the tour, the spacecraft would enter into an elliptical Titan orbit and perform extensive aerosampling while aerobraking in Titan's atmosphere. The spacecraft would execute a final periapsis raise burn to achieve a 1500 km circular, 85º polar orbit. This work was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under contract to NASA.

Development of a real-time chemical injection system for air-assisted variable-rate sprayers

USDA-ARS?s Scientific Manuscript database

A chemical injection system is an effective method to minimize chemical waste and reduce the environmental pollution in pesticide spray applications. A microprocessor controlled injection system implementing a ceramic piston metering pump was developed to accurately dispense chemicals to be mixed wi...

Three orbital transfer vehicles

NASA Technical Reports Server (NTRS)

1990-01-01

Aerospace engineering students at the Virginia Polytechnic Institute and State University undertook three design projects under the sponsorship of the NASA/USRA Advanced Space Design Program. All three projects addressed cargo and/or crew transportation between low Earth orbit and geosynchronous Earth orbit. Project SPARC presents a preliminary design of a fully reusable, chemically powered aeroassisted vehicle for a transfer of a crew of five and a 6000 to 20000 pound payload. The ASTV project outlines a chemically powered aeroassisted configuration that uses disposable tanks and a relatively small aerobrake to realize propellant savings. The third project, LOCOST, involves a reusable, hybrid laser/chemical vehicle designed for large cargo (up to 88,200 pounds) transportation.

Dynamic control and information processing in chemical reaction systems by tuning self-organization behavior

NASA Astrophysics Data System (ADS)

Lebiedz, Dirk; Brandt-Pollmann, Ulrich

2004-09-01

Specific external control of chemical reaction systems and both dynamic control and signal processing as central functions in biochemical reaction systems are important issues of modern nonlinear science. For example nonlinear input-output behavior and its regulation are crucial for the maintainance of the life process that requires extensive communication between cells and their environment. An important question is how the dynamical behavior of biochemical systems is controlled and how they process information transmitted by incoming signals. But also from a general point of view external forcing of complex chemical reaction processes is important in many application areas ranging from chemical engineering to biomedicine. In order to study such control issues numerically, here, we choose a well characterized chemical system, the CO oxidation on Pt(110), which is interesting per se as an externally forced chemical oscillator model. We show numerically that tuning of temporal self-organization by input signals in this simple nonlinear chemical reaction exhibiting oscillatory behavior can in principle be exploited for both specific external control of dynamical system behavior and processing of complex information.

Space-based laser-powered orbital transfer vehicle (Project SLICK)

NASA Technical Reports Server (NTRS)

1988-01-01

A conceptual design study of a laser-powered orbital transfer vehicle (LOTV) is presented. The LOTV, nicknamed SLICK (Space Laser Interorbital Cargo Kite), will be utilized for the transfer of 16000 kg of cargo between Low Earth Orbit (LEO) and either Geosynchronous Earth Orbit (GEO) or Low Lunar Orbit (LLO). This design concentrates primarily on the LEO/GEO scenario, which will have typical LEO-to-GEO trip time of 6 days and two return versions. One version uses an all propulsive return while the other utilizes a ballute aerobrake for the return trip. Furthermore, three return cargo options of 16000 kg, 5000 kg (standard option), and 1600 kg are considered for this scenario. The LEO/LLO scenario uses only a standard, aerobraked version. The basic concept behind the LOTV is that the power for the propulsion system is supplied by a source separate from the LOTV itself. For the LEO/GEO scenario the LOTV utilizes a direct solar-pumped iodide laser and possibly two relay stations, all orbiting at an altitude of one Earth radius and zero inclination. An additional nuclear-powered laser is placed on the Moon for the LEO/LLO scenario. The propulsion system of the LOTV consists of a single engine fueled with liquid hydrogen. The laser beam is captured and directed by a four mirror optical system through a window in the thrust chamber of the engine. There, seven plasmas are created to convert the laser beam energy into thermal energy at an efficiency of at least 50 percent. For the LEO/LLO scenario the laser propulsion is supplemented by LH2/LOX chemical thrusters.

TOXICITY-BASED CHEMICAL AGENT DETECTION SYSTEMS: CONTINUOUS MONITOR AND EXPOSURE HISTORY

EPA Science Inventory

This project will develop and characterize chemical agent detection systems that will provide broad toxicological screening information to first responders and building decontamination personnel. The primary goal for this technology is to detect the presence of airborne chemic...

Mars Sample Return Orbiter Rapid Architecture Study

NASA Astrophysics Data System (ADS)

Godfrey, A.; Johnson, M.; Stroud, C.

2018-04-01

An overview of rapid systems analysis (mass, risk, and schedule) on 1000s of MSRO configurations to understand key technologies and feasible options. Can we generate enough power? Can we aerobrake in time? Are some technology elements just too risky?

Hazard Classification of Household Chemical Products in Korea according to the Globally Harmonized System of Classification and labeling of Chemicals.

PubMed

Kim, Kyung-Hee; Song, Dae-Jong; Yu, Myeong-Hyun; Park, Yuon-Shin; Noh, Hye-Ran; Kim, Hae-Joon; Choi, Jae-Wook

2013-07-16

This study was conducted to review the validity of the need for the application of the Globally Harmonized System of Classification and Labeling of Chemicals (GHS) to household chemical products in Korea. The study also aimed to assess the severity of health and environmental hazards of household chemical products using the GHS. 135 products were classified as 'cleaning agents and polishing agents' and 98 products were classified as 'bleaches, disinfectants, and germicides.' The current status of carcinogenic classification of GHS and carcinogenicity was examined for 272 chemical substances contained in household chemical products by selecting the top 11 products for each of the product categories. In addition, the degree of toxicity was assessed through analysis of whether the standard of the Republic of Korea's regulations on household chemical products had been exceeded or not. According to GHS health and environmental hazards, "acute toxicity (oral)" was found to be the highest for two product groups, 'cleaning agents and polishing agents', and 'bleaches, disinfectants, and germicides' (result of classification of 233 household chemical products) at 37.8% and 52.0% respectively. In an analysis of carcinogenicity assuming a threshold of IARC 2B for the substances in household chemical products, we found 'cleaning agents and polishing agents' to contain 12 chemical substances and 'bleaches, disinfectants, and germicides' 11 chemical substances. Some of the household chemical products were found to have a high hazard level including acute toxicity and germ cell mutagenicity, carcinogenicity, and reproductive toxicity. Establishing a hazard information delivery system including the application of GHS to household chemical products in Korea is urgent as well.

Temporal cross-correlation asymmetry and departure from equilibrium in a bistable chemical system.

PubMed

Bianca, C; Lemarchand, A

2014-06-14

This paper aims at determining sustained reaction fluxes in a nonlinear chemical system driven in a nonequilibrium steady state. The method relies on the computation of cross-correlation functions for the internal fluctuations of chemical species concentrations. By employing Langevin-type equations, we derive approximate analytical formulas for the cross-correlation functions associated with nonlinear dynamics. Kinetic Monte Carlo simulations of the chemical master equation are performed in order to check the validity of the Langevin equations for a bistable chemical system. The two approaches are found in excellent agreement, except for critical parameter values where the bifurcation between monostability and bistability occurs. From the theoretical point of view, the results imply that the behavior of cross-correlation functions cannot be exploited to measure sustained reaction fluxes in a specific nonlinear system without the prior knowledge of the associated chemical mechanism and the rate constants.

Hazard Classification of Household Chemical Products in Korea according to the Globally Harmonized System of Classification and labeling of Chemicals

PubMed Central

2013-01-01

Objectives This study was conducted to review the validity of the need for the application of the Globally Harmonized System of Classification and Labeling of Chemicals (GHS) to household chemical products in Korea. The study also aimed to assess the severity of health and environmental hazards of household chemical products using the GHS. Methods 135 products were classified as ‘cleaning agents and polishing agents’ and 98 products were classified as ‘bleaches, disinfectants, and germicides.’ The current status of carcinogenic classification of GHS and carcinogenicity was examined for 272 chemical substances contained in household chemical products by selecting the top 11 products for each of the product categories. In addition, the degree of toxicity was assessed through analysis of whether the standard of the Republic of Korea’s regulations on household chemical products had been exceeded or not. Results According to GHS health and environmental hazards, “acute toxicity (oral)” was found to be the highest for two product groups, ‘cleaning agents and polishing agents’, and ‘bleaches, disinfectants, and germicides’ (result of classification of 233 household chemical products) at 37.8% and 52.0% respectively. In an analysis of carcinogenicity assuming a threshold of IARC 2B for the substances in household chemical products, we found ‘cleaning agents and polishing agents’ to contain 12 chemical substances and ‘bleaches, disinfectants, and germicides’ 11 chemical substances. Conclusion Some of the household chemical products were found to have a high hazard level including acute toxicity and germ cell mutagenicity, carcinogenicity, and reproductive toxicity. Establishing a hazard information delivery system including the application of GHS to household chemical products in Korea is urgent as well. PMID:24472347

Predictive spectroscopy and chemical imaging based on novel optical systems

NASA Astrophysics Data System (ADS)

Nelson, Matthew Paul

1998-10-01

This thesis describes two futuristic optical systems designed to surpass contemporary spectroscopic methods for predictive spectroscopy and chemical imaging. These systems are advantageous to current techniques in a number of ways including lower cost, enhanced portability, shorter analysis time, and improved S/N. First, a novel optical approach to predicting chemical and physical properties based on principal component analysis (PCA) is proposed and evaluated. A regression vector produced by PCA is designed into the structure of a set of paired optical filters. Light passing through the paired filters produces an analog detector signal directly proportional to the chemical/physical property for which the regression vector was designed. Second, a novel optical system is described which takes a single-shot approach to chemical imaging with high spectroscopic resolution using a dimension-reduction fiber-optic array. Images are focused onto a two- dimensional matrix of optical fibers which are drawn into a linear distal array with specific ordering. The distal end is imaged with a spectrograph equipped with an ICCD camera for spectral analysis. Software is used to extract the spatial/spectral information contained in the ICCD images and deconvolute them into wave length-specific reconstructed images or position-specific spectra which span a multi-wavelength space. This thesis includes a description of the fabrication of two dimension-reduction arrays as well as an evaluation of the system for spatial and spectral resolution, throughput, image brightness, resolving power, depth of focus, and channel cross-talk. PCA is performed on the images by treating rows of the ICCD images as spectra and plotting the scores of each PC as a function of reconstruction position. In addition, iterative target transformation factor analysis (ITTFA) is performed on the spectroscopic images to generate ``true'' chemical maps of samples. Univariate zero-order images, univariate first

Some Sensitivity Studies of Chemical Transport Simulated in Models of the Soil-Plant-Litter System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Begovich, C.L.

2002-10-28

Fifteen parameters in a set of five coupled models describing carbon, water, and chemical dynamics in the soil-plant-litter system were varied in a sensitivity analysis of model response. Results are presented for chemical distribution in the components of soil, plants, and litter along with selected responses of biomass, internal chemical transport (xylem and phloem pathways), and chemical uptake. Response and sensitivity coefficients are presented for up to 102 model outputs in an appendix. Two soil properties (chemical distribution coefficient and chemical solubility) and three plant properties (leaf chemical permeability, cuticle thickness, and root chemical conductivity) had the greatest influence onmore » chemical transport in the soil-plant-litter system under the conditions examined. Pollutant gas uptake (SO{sub 2}) increased with change in plant properties that increased plant growth. Heavy metal dynamics in litter responded to plant properties (phloem resistance, respiration characteristics) which induced changes in the chemical cycling to the litter system. Some of the SO{sub 2} and heavy metal responses were not expected but became apparent through the modeling analysis.« less

Spacecraft Chemical Propulsion Systems at NASA's Marshall Space Flight Center: Heritage and Capabilities

NASA Technical Reports Server (NTRS)

McRight, Patrick S.; Sheehy, Jeffrey A.; Blevins, John A.

2005-01-01

NASA Marshall Space Flight Center (MSFC) is well known for its contributions to large ascent propulsion systems such as the Saturn V and the Space Shuttle. This paper highlights a lesser known but equally rich side of MSFC - its heritage in spacecraft chemical propulsion systems and its current capabilities for in-space propulsion system development and chemical propulsion research. The historical narrative describes the efforts associated with developing upper-stage main propulsion systems such as the Saturn S-IVB as well as orbital maneuvering and reaction control systems such as the S-IVB auxiliary propulsion system, the Skylab thruster attitude control system, and many more recent activities such as Chandra, the Demonstration of Automated Rendezvous Technology, X-37, the X-38 de-orbit propulsion system, the Interim Control Module, the US Propulsion Module, and several technology development activities. Also discussed are MSFC chemical propulsion research capabilities, along with near- and long-term technology challenges to which MSFC research and system development competencies are relevant.

Biodegradation of organic chemicals in soil/water microcosms system: Model development

USGS Publications Warehouse

Liu, L.; Tindall, J.A.; Friedel, M.J.; Zhang, W.

2007-01-01

The chemical interactions of hydrophobic organic contaminants with soils and sediments may result in strong binding and slow subsequent release rates that significantly affect remediation rates and endpoints. In order to illustrate the recalcitrance of chemical to degradation on sites, a sorption mechanism of intraparticle sequestration was postulated to operate on chemical remediation sites. Pseudo-first order sequestration kinetics is used in the study with the hypothesis that sequestration is an irreversibly surface-mediated process. A mathematical model based on mass balance equations was developed to describe the fate of chemical degradation in soil/water microcosm systems. In the model, diffusion was represented by Fick's second law, local sorption-desorption by a linear isotherm, irreversible sequestration by a pseudo-first order kinetics and biodegradation by Monod kinetics. Solutions were obtained to provide estimates of chemical concentrations. The mathematical model was applied to a benzene biodegradation batch test and simulated model responses correlated well compared to measurements of biodegradation of benzene in the batch soil/water microcosm system. A sensitivity analysis was performed to assess the effects of several parameters on model behavior. Overall chemical removal rate decreased and sequestration increased quickly with an increase in the sorption partition coefficient. When soil particle radius, a, was greater than 1 mm, an increase in radius produced a significant decrease in overall chemical removal rate as well as an increase in sequestration. However, when soil particle radius was less than 0.1 mm, an increase in radius resulted in small changes in the removal rate and sequestration. As pseudo-first order sequestration rate increased, both chemical removal rate and sequestration increased slightly. Model simulation results showed that desorption resistance played an important role in the bioavailability of organic chemicals in porous

Periodic pulses of calcium ions in a chemical system.

PubMed

Kurin-Csörgei, Krisztina; Epstein, Irving R; Orban, Miklós

2006-06-22

By coupling the bromate-sulfite-ferrocyanide oscillating chemical reaction with the complexation of calcium ion by EDTA, we construct a system that generates periodic pulses of free Ca(2+) with an amplitude of 2 orders of magnitude and a period of ca. 20 min. These pulses may be observed either with a calcium ion-selective electrode or with Arsenazo(III) as an indicator. We describe the systematic design procedure and the properties of this first abiotic calcium-based chemical oscillator.

Method and system for extraction of chemicals from aquifer remediation effluent water

DOEpatents

McMurtrey, Ryan D.; Ginosar, Daniel M.; Moor, Kenneth S.; Shook, G. Michael; Barker, Donna L.

2003-01-01

A method and system for extraction of chemicals from an groundwater remediation aqueous effluent are provided. The extraction method utilizes a critical fluid for separation and recovery of chemicals employed in remediating groundwater contaminated with hazardous organic substances, and is particularly suited for separation and recovery of organic contaminants and process chemicals used in surfactant-based remediation technologies. The extraction method separates and recovers high-value chemicals from the remediation effluent and minimizes the volume of generated hazardous waste. The recovered chemicals can be recycled to the remediation process or stored for later use.

40 CFR 749.68 - Hexavalent chromium-based water treatment chemicals in cooling systems.

Code of Federal Regulations, 2011 CFR

2011-07-01

... tower used to remove heat from industrial processes, chemical reactions, or plants producing electrical... treatment chemicals in cooling systems. 749.68 Section 749.68 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT WATER TREATMENT CHEMICALS Air Conditioning and...

40 CFR 749.68 - Hexavalent chromium-based water treatment chemicals in cooling systems.

Code of Federal Regulations, 2012 CFR

2012-07-01

... tower used to remove heat from industrial processes, chemical reactions, or plants producing electrical... treatment chemicals in cooling systems. 749.68 Section 749.68 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT WATER TREATMENT CHEMICALS Air Conditioning and...

40 CFR 749.68 - Hexavalent chromium-based water treatment chemicals in cooling systems.

Code of Federal Regulations, 2013 CFR

2013-07-01

... tower used to remove heat from industrial processes, chemical reactions, or plants producing electrical... treatment chemicals in cooling systems. 749.68 Section 749.68 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT WATER TREATMENT CHEMICALS Air Conditioning and...

40 CFR 749.68 - Hexavalent chromium-based water treatment chemicals in cooling systems.

Code of Federal Regulations, 2014 CFR

2014-07-01

... tower used to remove heat from industrial processes, chemical reactions, or plants producing electrical... treatment chemicals in cooling systems. 749.68 Section 749.68 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT WATER TREATMENT CHEMICALS Air Conditioning and...

Model reduction for stochastic chemical systems with abundant species.

PubMed

Smith, Stephen; Cianci, Claudia; Grima, Ramon

2015-12-07

Biochemical processes typically involve many chemical species, some in abundance and some in low molecule numbers. We first identify the rate constant limits under which the concentrations of a given set of species will tend to infinity (the abundant species) while the concentrations of all other species remains constant (the non-abundant species). Subsequently, we prove that, in this limit, the fluctuations in the molecule numbers of non-abundant species are accurately described by a hybrid stochastic description consisting of a chemical master equation coupled to deterministic rate equations. This is a reduced description when compared to the conventional chemical master equation which describes the fluctuations in both abundant and non-abundant species. We show that the reduced master equation can be solved exactly for a number of biochemical networks involving gene expression and enzyme catalysis, whose conventional chemical master equation description is analytically impenetrable. We use the linear noise approximation to obtain approximate expressions for the difference between the variance of fluctuations in the non-abundant species as predicted by the hybrid approach and by the conventional chemical master equation. Furthermore, we show that surprisingly, irrespective of any separation in the mean molecule numbers of various species, the conventional and hybrid master equations exactly agree for a class of chemical systems.

Chemical environments of submarine hydrothermal systems. [supporting abiogenetic theory

NASA Technical Reports Server (NTRS)

Shock, Everett L.

1992-01-01

The paper synthesizes diverse information about the inorganic geochemistry of submarine hydrothermal systems, provides a description of the fundamental physical and chemical properties of these systems, and examines the implications of high-temperature, fluid-driven processes for organic synthesis. Emphasis is on a few general features, i.e., pressure, temperature, oxidation states, fluid composition, and mineral alteration, because these features will control whether organic synthesis can occur in hydrothermal systems.

Chemical Sensor Systems and Associated Algorithms for Fire Detection: A Review.

PubMed

Fonollosa, Jordi; Solórzano, Ana; Marco, Santiago

2018-02-11

Indoor fire detection using gas chemical sensing has been a subject of investigation since the early nineties. This approach leverages the fact that, for certain types of fire, chemical volatiles appear before smoke particles do. Hence, systems based on chemical sensing can provide faster fire alarm responses than conventional smoke-based fire detectors. Moreover, since it is known that most casualties in fires are produced from toxic emissions rather than actual burns, gas-based fire detection could provide an additional level of safety to building occupants. In this line, since the 2000s, electrochemical cells for carbon monoxide sensing have been incorporated into fire detectors. Even systems relying exclusively on gas sensors have been explored as fire detectors. However, gas sensors respond to a large variety of volatiles beyond combustion products. As a result, chemical-based fire detectors require multivariate data processing techniques to ensure high sensitivity to fires and false alarm immunity. In this paper, we the survey toxic emissions produced in fires and defined standards for fire detection systems. We also review the state of the art of chemical sensor systems for fire detection and the associated signal and data processing algorithms. We also examine the experimental protocols used for the validation of the different approaches, as the complexity of the test measurements also impacts on reported sensitivity and specificity measures. All in all, further research and extensive test under different fire and nuisance scenarios are still required before gas-based fire detectors penetrate largely into the market. Nevertheless, the use of dynamic features and multivariate models that exploit sensor correlations seems imperative.

Chemical Sensor Systems and Associated Algorithms for Fire Detection: A Review

PubMed Central

Fonollosa, Jordi

2018-01-01

Indoor fire detection using gas chemical sensing has been a subject of investigation since the early nineties. This approach leverages the fact that, for certain types of fire, chemical volatiles appear before smoke particles do. Hence, systems based on chemical sensing can provide faster fire alarm responses than conventional smoke-based fire detectors. Moreover, since it is known that most casualties in fires are produced from toxic emissions rather than actual burns, gas-based fire detection could provide an additional level of safety to building occupants. In this line, since the 2000s, electrochemical cells for carbon monoxide sensing have been incorporated into fire detectors. Even systems relying exclusively on gas sensors have been explored as fire detectors. However, gas sensors respond to a large variety of volatiles beyond combustion products. As a result, chemical-based fire detectors require multivariate data processing techniques to ensure high sensitivity to fires and false alarm immunity. In this paper, we the survey toxic emissions produced in fires and defined standards for fire detection systems. We also review the state of the art of chemical sensor systems for fire detection and the associated signal and data processing algorithms. We also examine the experimental protocols used for the validation of the different approaches, as the complexity of the test measurements also impacts on reported sensitivity and specificity measures. All in all, further research and extensive test under different fire and nuisance scenarios are still required before gas-based fire detectors penetrate largely into the market. Nevertheless, the use of dynamic features and multivariate models that exploit sensor correlations seems imperative. PMID:29439490

ENGINEERED BARRIER SYSTEM: PHYSICAL AND CHEMICAL ENVIRONMENT

DOE Office of Scientific and Technical Information (OSTI.GOV)

R. Jarek

2005-08-29

The purpose of this model report is to describe the evolution of the physical and chemical environmental conditions within the waste emplacement drifts of the repository, including the drip shield and waste package surfaces. The resulting seepage evaporation and gas abstraction models are used in the total system performance assessment for the license application (TSPA-LA) to assess the performance of the engineered barrier system and the waste form. This report develops and documents a set of abstraction-level models that describe the engineered barrier system physical and chemical environment. Where possible, these models use information directly from other reports as input,more » which promotes integration among process models used for TSPA-LA. Specific tasks and activities of modeling the physical and chemical environment are included in ''Technical Work Plan for: Near-Field Environment and Transport In-Drift Geochemistry Model Report Integration'' (BSC 2005 [DIRS 173782], Section 1.2.2). As described in the technical work plan, the development of this report is coordinated with the development of other engineered barrier system reports. To be consistent with other project documents that address features, events, and processes (FEPs), Table 6.14.1 of the current report includes updates to FEP numbers and FEP subjects for two FEPs identified in the technical work plan (TWP) governing this report (BSC 2005 [DIRS 173782]). FEP 2.1.09.06.0A (Reduction-oxidation potential in EBS), as listed in Table 2 of the TWP (BSC 2005 [DIRS 173782]), has been updated in the current report to FEP 2.1.09.06.0B (Reduction-oxidation potential in Drifts; see Table 6.14-1). FEP 2.1.09.07.0A (Reaction kinetics in EBS), as listed in Table 2 of the TWP (BSC 2005 [DIRS 173782]), has been updated in the current report to FEP 2.1.09.07.0B (Reaction kinetics in Drifts; see Table 6.14-1). These deviations from the TWP are justified because they improve integration with FEPs documents. The

A survey of chemicals inducing lipid peroxidation in biological systems.

PubMed

Kappus, H

1987-01-01

A great number of drugs and chemicals are reviewed which have been shown to stimulate lipid peroxidation in any biological system. The underlying mechanisms, as far as known, are also dealt with. Lipid peroxidation induced by iron ions, organic hydroperoxides, halogenated hydrocarbons, redox cycling drugs, glutathione depleting chemicals, ethanol, heavy metals, ozone, nitrogen dioxide and a number of miscellaneous compounds, e.g. hydrazines, pesticides, antibiotics, are mentioned. It is shown that lipid peroxidation is stimulated by many of these compounds. However, quantitative estimates cannot be given yet and it is still impossible to judge the biological relevance of chemical-induced lipid peroxidation.

Technology needs for lunar and Mars space transfer systems

NASA Technical Reports Server (NTRS)

Woodcock, Gordon R.; Cothran, Bradley C.; Donahue, Benjamin; Mcghee, Jerry

1991-01-01

The determination of appropriate space transportation technologies and operating modes is discussed with respect to both lunar and Mars missions. Three levels of activity are set forth to examine the sensitivity of transportation preferences including 'minimum,' 'full science,' and 'industrialization and settlement' categories. High-thrust-profile missions for lunar and Mars transportation are considered in terms of their relative advantages, and transportation options are defined in terms of propulsion and braking technologies. Costs and life-cycle cost estimates are prepared for the transportation preferences by using a parametric cost model, and a return-on-investment summary is given. Major technological needs for the programs are listed and include storable propulsion systems; cryogenic engines and fluids management; aerobraking; and nuclear thermal, nuclear electric, electric, and solar electric propulsion technologies.

Chemically generated convective transport in microfluidic system

NASA Astrophysics Data System (ADS)

Shklyaev, Oleg; Das, Sambeeta; Altemose, Alicia; Shum, Henry; Balazs, Anna; Sen, Ayusman

High precision manipulation of small volumes of fluid, containing suspended micron sized objects like cells, viruses, and large molecules, is one of the main goals in designing modern lab-on-a-chip devices which can find a variety of chemical and biological applications. To transport the cargo toward sensing elements, typical microfluidic devices often use pressure driven flows. Here, we propose to use enzymatic chemical reactions which decompose reagent into less dense products and generate flows that can transport particles. Density variations that lead to flow in the assigned direction are created between the place where reagent is fed into the solution and the location where it is decomposed by enzymes attached to the surface of the microchannel. When the reagent is depleted, the fluid motion stops and particles sediment to the bottom. We demonstrate how the choice of chemicals, leading to specific reaction rates, can affect the transport properties. In particular, we show that the intensity of the fluid flow, the final location of cargo, and the time for cargo delivery are controlled by the amount and type of reagent in the system.

Building an R&D chemical registration system.

PubMed

Martin, Elyette; Monge, Aurélien; Duret, Jacques-Antoine; Gualandi, Federico; Peitsch, Manuel C; Pospisil, Pavel

2012-05-31

Small molecule chemistry is of central importance to a number of R&D companies in diverse areas such as the pharmaceutical, nutraceutical, food flavoring, and cosmeceutical industries. In order to store and manage thousands of chemical compounds in such an environment, we have built a state-of-the-art master chemical database with unique structure identifiers. Here, we present the concept and methodology we used to build the system that we call the Unique Compound Database (UCD). In the UCD, each molecule is registered only once (uniqueness), structures with alternative representations are entered in a uniform way (normalization), and the chemical structure drawings are recognizable to chemists and to a cartridge. In brief, structural molecules are entered as neutral entities which can be associated with a salt. The salts are listed in a dictionary and bound to the molecule with the appropriate stoichiometric coefficient in an entity called "substance". The substances are associated with batches. Once a molecule is registered, some properties (e.g., ADMET prediction, IUPAC name, chemical properties) are calculated automatically. The UCD has both automated and manual data controls. Moreover, the UCD concept enables the management of user errors in the structure entry by reassigning or archiving the batches. It also allows updating of the records to include newly discovered properties of individual structures. As our research spans a wide variety of scientific fields, the database enables registration of mixtures of compounds, enantiomers, tautomers, and compounds with unknown stereochemistries.

Lightweight Ablative and Ceramic Thermal Protection System Materials for NASA Exploration Systems Vehicles

NASA Technical Reports Server (NTRS)

Valentine, Peter G.; Lawrence, Timothy W.; Gubert, Michael K.; Milos, Frank S.; Kiser, James D.; Ohlhorst, Craig W.; Koenig, John R.

2006-01-01

As a collaborative effort among NASA Centers, the "Lightweight Nonmetallic Thermal Protection Materials Technology" Project was set up to assist mission/vehicle design trade studies, to support risk reduction in thermal protection system (TPS) material selections, to facilitate vehicle mass optimization, and to aid development of human-rated TPS qualification and certification plans. Missions performing aerocapture, aerobraking, or direct aeroentry rely on advanced heatshields that allow reductions in spacecraft mass by minimizing propellant requirements. Information will be presented on candidate materials for such reentry approaches and on screening tests conducted (material property and space environmental effects tests) to evaluate viable candidates. Seventeen materials, in three classes (ablatives, tiles, and ceramic matrix composites), were studied. In additional to physical, mechanical, and thermal property tests, high heat flux laser tests and simulated-reentry oxidation tests were performed. Space environmental effects testing, which included exposures to electrons, atomic oxygen, and hypervelocity impacts, was also conducted.

Nomenclature associated with chemical characterization of and compatibility evaluations for medical product delivery systems.

PubMed

Jenke, Dennis R

2003-01-01

Delivery systems are used to store, contain, and/or administer liquid pharmaceutical products. Gaining an understanding of the chemical composition of such a delivery system is necessary with respect to effective system development, registration, and production. Additionally, the ability of the delivery system to impact the chemical composition of the contacted product may define the safety and/or efficacy of the product. Assessing the compatibility of the delivery system and the product is thus both necessary and desirable. The nomenclature associated with compatibility assessments has not been standardized, oftimes leading to conflicting or confusing information. This manuscript puts forth a nomenclature which classifies those chemical entities which participate in the system/product interaction and delineates the various extraction strategies which may be used in compatibility assessments.

Technology for Future NASA Missions: Civil Space Technology Initiative (CSTI) and Pathfinder

NASA Technical Reports Server (NTRS)

1988-01-01

Information is presented in viewgraph form on a number of related topics. Information is given on orbit transfer vehicles, spacecraft instruments, spaceborne experiments, university/industry programs, spacecraft propulsion, life support systems, cryogenics, spacecraft power supplies, human factors engineering, spacecraft construction materials, aeroassist, aerobraking and aerothermodynamics.

Model reduction for stochastic chemical systems with abundant species

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, Stephen; Cianci, Claudia; Grima, Ramon

2015-12-07

Biochemical processes typically involve many chemical species, some in abundance and some in low molecule numbers. We first identify the rate constant limits under which the concentrations of a given set of species will tend to infinity (the abundant species) while the concentrations of all other species remains constant (the non-abundant species). Subsequently, we prove that, in this limit, the fluctuations in the molecule numbers of non-abundant species are accurately described by a hybrid stochastic description consisting of a chemical master equation coupled to deterministic rate equations. This is a reduced description when compared to the conventional chemical master equationmore » which describes the fluctuations in both abundant and non-abundant species. We show that the reduced master equation can be solved exactly for a number of biochemical networks involving gene expression and enzyme catalysis, whose conventional chemical master equation description is analytically impenetrable. We use the linear noise approximation to obtain approximate expressions for the difference between the variance of fluctuations in the non-abundant species as predicted by the hybrid approach and by the conventional chemical master equation. Furthermore, we show that surprisingly, irrespective of any separation in the mean molecule numbers of various species, the conventional and hybrid master equations exactly agree for a class of chemical systems.« less

Assessing the Relative Risk of Aerocapture Using Probabalistic Risk Assessment

NASA Technical Reports Server (NTRS)

Percy, Thomas K.; Bright, Ellanee; Torres, Abel O.

2005-01-01

A recent study performed for the Aerocapture Technology Area in the In-Space Propulsion Technology Projects Office at the Marshall Space Flight Center investigated the relative risk of various capture techniques for Mars missions. Aerocapture has been proposed as a possible capture technique for future Mars missions but has been perceived by many in the community as a higher risk option as compared to aerobraking and propulsive capture. By performing a probabilistic risk assessment on aerocapture, aerobraking and propulsive capture, a comparison was made to uncover the projected relative risks of these three maneuvers. For mission planners, this knowledge will allow them to decide if the mass savings provided by aerocapture warrant any incremental risk exposure. The study focuses on a Mars Sample Return mission currently under investigation at the Jet Propulsion Laboratory (JPL). In each case (propulsive, aerobraking and aerocapture), the Earth return vehicle is inserted into Martian orbit by one of the three techniques being investigated. A baseline spacecraft was established through initial sizing exercises performed by JPL's Team X. While Team X design results provided the baseline and common thread between the spacecraft, in each case the Team X results were supplemented by historical data as needed. Propulsion, thermal protection, guidance, navigation and control, software, solar arrays, navigation and targeting and atmospheric prediction were investigated. A qualitative assessment of human reliability was also included. Results show that different risk drivers contribute significantly to each capture technique. For aerocapture, the significant drivers include propulsion system failures and atmospheric prediction errors. Software and guidance hardware contribute the most to aerobraking risk. Propulsive capture risk is mainly driven by anomalous solar array degradation and propulsion system failures. While each subsystem contributes differently to the risk of

Chemical detection system and related methods

DOE Office of Scientific and Technical Information (OSTI.GOV)

Caffrey, Augustine J.; Chichester, David L.; Egger, Ann E.

2017-06-27

A chemical detection system includes a frame, an emitter coupled to the frame, and a detector coupled to the frame proximate the emitter. The system also includes a shielding system coupled to the frame and positioned at least partially between the emitter and the detector, wherein the frame positions a sensing surface of the detector in a direction substantially parallel to a plane extending along a front portion of the frame. A method of analyzing composition of a suspect object includes directing neutrons at the object, detecting gamma rays emitted from the object, and communicating spectrometer information regarding the gammamore » rays. The method also includes presenting a GUI to a user with a dynamic status of an ongoing neutron spectroscopy process. The dynamic status includes a present confidence for a plurality of compounds being present in the suspect object responsive to changes in the spectrometer information during the ongoing process.« less

The System of Chemical Elements Distribution in the Hydrosphere

NASA Astrophysics Data System (ADS)

Korzh, Vyacheslav D.

2013-04-01

The chemical composition of the hydrosphere is a result of substance migration and transformation on lithosphere-river, river-sea, and ocean-atmosphere boundaries. The chemical elements composition of oceanic water is a fundamental multi-dimensional constant for our planet. Detailed studies revealed three types of chemical element distribution in the ocean: 1) Conservative: concentration normalized to salinity is the constant in space and time; 2) Nutrient-type: element concentration in the surface waters decreases due to the biosphere consumption; and 3) Litho-generative: complex character of distribution of elements, which enter the ocean with the river runoff and interred almost entirely in sediments. The correlation between the chemical elements compositions of the river and oceanic water is high (r = 0.94). We conclude that biogeochemical features of each chemical element are determined by the relationship between its average concentration in the ocean and the intensity of its migration through hydrosphere boundary zones. In our presentation, we shall show intensities of global migration and average concentrations in the ocean in the co ordinates lgC - lg [tau], where C is an average element concentration and [tau] is its residence time in the ocean. We have derived a relationship between three main geochemical parameters of the dissolved forms of chemical elements in the hydrosphere: 1) average concentration in the ocean, 2) average concentration in the river runoff and 3) the type of distribution in oceanic water. Using knowledge of two of these parameters, it allows gaining theoretical knowledge of the third. The System covers all chemical elements for the entire range of observed concentrations. It even allows to predict the values of the annual river transport of dissolved Be, C, N, Ge, Tl, Re, to refine such estimates for P, V, Zn, Br, I, and to determine the character of distribution in the ocean for Au and U. Furthermore, the System allowed estimating

AN ADVANCED SYSTEM FOR POLLUTION PREVENTION IN CHEMICAL COMPLEXES

EPA Science Inventory

One important accomplishment is that the system will give process engineers interactively and simultaneously use of programs for total cost analysis, life cycle assessment and sustainability metrics to provide direction for the optimal chemical complex analysis pro...

DAWN (Design Assistant Workstation) for advanced physical-chemical life support systems

NASA Technical Reports Server (NTRS)

Rudokas, Mary R.; Cantwell, Elizabeth R.; Robinson, Peter I.; Shenk, Timothy W.

1989-01-01

This paper reports the results of a project supported by the National Aeronautics and Space Administration, Office of Aeronautics and Space Technology (NASA-OAST) under the Advanced Life Support Development Program. It is an initial attempt to integrate artificial intelligence techniques (via expert systems) with conventional quantitative modeling tools for advanced physical-chemical life support systems. The addition of artificial intelligence techniques will assist the designer in the definition and simulation of loosely/well-defined life support processes/problems as well as assist in the capture of design knowledge, both quantitative and qualitative. Expert system and conventional modeling tools are integrated to provide a design workstation that assists the engineer/scientist in creating, evaluating, documenting and optimizing physical-chemical life support systems for short-term and extended duration missions.

Recent advances in microbial production of fuels and chemicals using tools and strategies of systems metabolic engineering.

PubMed

Cho, Changhee; Choi, So Young; Luo, Zi Wei; Lee, Sang Yup

2015-11-15

The advent of various systems metabolic engineering tools and strategies has enabled more sophisticated engineering of microorganisms for the production of industrially useful fuels and chemicals. Advances in systems metabolic engineering have been made in overproducing natural chemicals and producing novel non-natural chemicals. In this paper, we review the tools and strategies of systems metabolic engineering employed for the development of microorganisms for the production of various industrially useful chemicals belonging to fuels, building block chemicals, and specialty chemicals, in particular focusing on those reported in the last three years. It was aimed at providing the current landscape of systems metabolic engineering and suggesting directions to address future challenges towards successfully establishing processes for the bio-based production of fuels and chemicals from renewable resources. Copyright © 2014 Elsevier Inc. All rights reserved.

Fire Hazard Assessment in Supporting Fire Protection System Design of a Chemical Process Facility

DTIC Science & Technology

1996-08-01

CSDP/Studies/FireHaz –i– 3/28/97 FIRE HAZARD ASSESSMENT IN SUPPORTING FIRE PROTECTION SYSTEM DESIGN OF A CHEMICAL PROCESS FACILITY Ali Pezeshk...Joseph Chang, Dwight Hunt, and Peter Jahn Parsons Infrastructure & Technology Group, Inc. Pasadena, California 91124 ABSTRACT Because fires in a chemical ...Assessment in Supporting Fire Protection System Design of a Chemical Process Facility 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6

WAR DSS: A DECISION SUPPORT SYSTEM FOR ENVIRONMENTALLY CONSCIOUS CHEMICAL PROCESS DESIGN

EPA Science Inventory

The second generation of the Waste Reduction (WAR) Algorithm is constructed as a decision support system (DSS) in the design of chemical manufacturing facilities. The WAR DSS is a software tool that can help reduce the potential environmental impacts (PEIs) of industrial chemical...

Closed-Loop Control of Chemical Injection Rate for a Direct Nozzle Injection System.

PubMed

Cai, Xiang; Walgenbach, Martin; Doerpmond, Malte; Schulze Lammers, Peter; Sun, Yurui

2016-01-20

To realize site-specific and variable-rate application of agricultural pesticides, accurately metering and controlling the chemical injection rate is necessary. This study presents a prototype of a direct nozzle injection system (DNIS) by which chemical concentration transport lag was greatly reduced. In this system, a rapid-reacting solenoid valve (RRV) was utilized for injecting chemicals, driven by a pulse-width modulation (PWM) signal at 100 Hz, so with varying pulse width the chemical injection rate could be adjusted. Meanwhile, a closed-loop control strategy, proportional-integral-derivative (PID) method, was applied for metering and stabilizing the chemical injection rate. In order to measure chemical flow rates and input them into the controller as a feedback in real-time, a thermodynamic flowmeter that was independent of chemical viscosity was used. Laboratory tests were conducted to assess the performance of DNIS and PID control strategy. Due to the nonlinear input-output characteristics of the RRV, a two-phase PID control process obtained better effects as compared with single PID control strategy. Test results also indicated that the set-point chemical flow rate could be achieved within less than 4 s, and the output stability was improved compared to the case without control strategy.

Closed-Loop Control of Chemical Injection Rate for a Direct Nozzle Injection System

PubMed Central

Cai, Xiang; Walgenbach, Martin; Doerpmond, Malte; Schulze Lammers, Peter; Sun, Yurui

2016-01-01

To realize site-specific and variable-rate application of agricultural pesticides, accurately metering and controlling the chemical injection rate is necessary. This study presents a prototype of a direct nozzle injection system (DNIS) by which chemical concentration transport lag was greatly reduced. In this system, a rapid-reacting solenoid valve (RRV) was utilized for injecting chemicals, driven by a pulse-width modulation (PWM) signal at 100 Hz, so with varying pulse width the chemical injection rate could be adjusted. Meanwhile, a closed-loop control strategy, proportional-integral-derivative (PID) method, was applied for metering and stabilizing the chemical injection rate. In order to measure chemical flow rates and input them into the controller as a feedback in real-time, a thermodynamic flowmeter that was independent of chemical viscosity was used. Laboratory tests were conducted to assess the performance of DNIS and PID control strategy. Due to the nonlinear input–output characteristics of the RRV, a two-phase PID control process obtained better effects as compared with single PID control strategy. Test results also indicated that the set-point chemical flow rate could be achieved within less than 4 s, and the output stability was improved compared to the case without control strategy. PMID:26805833

Measurement of Fluorine Atom Concentrations and Reaction Rates in Chemical Laser Systems.

DTIC Science & Technology

1981-09-01

AD-A1RA 070 AERODYNEERESEARCHUINC BEDFORDM MA F/6_20/5 MEASURE MENT OF FLUORINE ATOM CONCENTRATIONS AND REACTION RATFS -ETC(U) SEP_ A A C STANT ON...0772 LEVELIg 00 ~ARI-RR-272 cO0 MEASUREMENT OF FLUORINE ATOM CONCENTRATIONS AND REACTION RATES IN CHEMICAL LASER SYSTEMS ANNUAL TECHNICAL REPORT by...MEASUREMENT OF FLUORINE ATOM CONCENTRATIONS AND Annual Report REACTION RATES IN CHEMICAL LASER SYSTEMS 23 July 1980 - 23 July 1981 S. PERFORMING ORG. REPORT

Thermal protection systems manned spacecraft flight experience

NASA Technical Reports Server (NTRS)

Curry, Donald M.

1992-01-01

Since the first U.S. manned entry, Mercury (May 5, 1961), seventy-five manned entries have been made resulting in significant progress in the understanding and development of Thermal Protection Systems (TPS) for manned rated spacecraft. The TPS materials and systems installed on these spacecraft are compared. The first three vehicles (Mercury, Gemini, Apollo) used ablative (single-use) systems while the Space Shuttle Orbiter TPS is a multimission system. A TPS figure of merit, unit weight lb/sq ft, illustrates the advances in TPS material performance from Mercury (10.2 lb/sq ft) to the Space Shuttle (1.7 lb/sq ft). Significant advances have been made in the design, fabrication, and certification of TPS on manned entry vehicles (Mercury through Shuttle Orbiter). Shuttle experience has identified some key design and operational issues. State-of-the-art ceramic insulation materials developed in the 1970's for the Space Shuttle Orbiter have been used in the initial designs of aerobrakes. This TPS material experience has identified the need to develop a technology base from which a new class of higher temperature materials will emerge for advanced space transportation vehicles.

Transport-induced shifts in condensate dew-point and composition in multicomponent systems with chemical reaction

NASA Technical Reports Server (NTRS)

Rosner, D. E.; Nagarajan, R.

1985-01-01

Partial heterogeneous condensation phenomena in multicomponent reacting systems are analyzed taking into consideration the chemical element transport phenomena. It is demonstrated that the dew-point surface temperature in chemically reactive systems is not a purely thermodynamic quantity, but is influenced by the multicomponent diffusion and Soret-mass diffusion phenomena. Several distinct dew-points are shown to exist in such systems and, as a result of transport constraints, the 'sharp' locus between two chemically distinct condensates is systematically moved to a difference mainstream composition.

A Titan Explorer Mission Utilizing Solar Electric Propulsion and Chemical Propulsion Systems

NASA Technical Reports Server (NTRS)

Cupples, Michael; Coverstone, Vicki

2003-01-01

Mission and Systems analyses were performed for a Titan Explorer Mission scenario utilizing medium class launch vehicles, solar electric propulsion system (SEPS) for primary interplanetary propulsion, and chemical propulsion for capture at Titan. An examination of a range of system factors was performed to determine their affect on the payload delivery capability to Titan. The effect of varying the launch vehicle, solar array power, associated number of SEPS thrusters, chemical propellant combinations, tank liner thickness, and tank composite overwrap stress factor was investigated. This paper provides a parametric survey of the aforementioned set of system factors, delineating their affect on Titan payload delivery, as well as discussing aspects of planetary capture methodology.

Operational atmospheric modeling system CARIS for effective emergency response associated with hazardous chemical releases in Korea.

PubMed

Kim, Cheol-Hee; Park, Jin-Ho; Park, Cheol-Jin; Na, Jin-Gyun

2004-03-01

The Chemical Accidents Response Information System (CARIS) was developed at the Center for Chemical Safety Management in South Korea in order to track and predict the dispersion of hazardous chemicals in the case of an accident or terrorist attack involving chemical companies. The main objective of CARIS is to facilitate an efficient emergency response to hazardous chemical accidents by rapidly providing key information in the decision-making process. In particular, the atmospheric modeling system implemented in CARIS, which is composed of a real-time numerical weather forecasting model and an air pollution dispersion model, can be used as a tool to forecast concentrations and to provide a wide range of assessments associated with various hazardous chemicals in real time. This article introduces the components of CARIS and describes its operational modeling system. Some examples of the operational modeling system and its use for emergency preparedness are presented and discussed. Finally, this article evaluates the current numerical weather prediction model for Korea.

APOLLO: A computer program for the calculation of chemical equilibrium and reaction kinetics of chemical systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nguyen, H.D.

1991-11-01

Several of the technologies being evaluated for the treatment of waste material involve chemical reactions. Our example is the in situ vitrification (ISV) process where electrical energy is used to melt soil and waste into a ``glass like`` material that immobilizes and encapsulates any residual waste. During the ISV process, various chemical reactions may occur that produce significant amounts of products which must be contained and treated. The APOLLO program was developed to assist in predicting the composition of the gases that are formed. Although the development of this program was directed toward ISV applications, it should be applicable tomore » other technologies where chemical reactions are of interest. This document presents the mathematical methodology of the APOLLO computer code. APOLLO is a computer code that calculates the products of both equilibrium and kinetic chemical reactions. The current version, written in FORTRAN, is readily adaptable to existing transport programs designed for the analysis of chemically reacting flow systems. Separate subroutines EQREACT and KIREACT for equilibrium ad kinetic chemistry respectively have been developed. A full detailed description of the numerical techniques used, which include both Lagrange multiplies and a third-order integrating scheme is presented. Sample test problems are presented and the results are in excellent agreement with those reported in the literature.« less

APOLLO: A computer program for the calculation of chemical equilibrium and reaction kinetics of chemical systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nguyen, H.D.

1991-11-01

Several of the technologies being evaluated for the treatment of waste material involve chemical reactions. Our example is the in situ vitrification (ISV) process where electrical energy is used to melt soil and waste into a glass like'' material that immobilizes and encapsulates any residual waste. During the ISV process, various chemical reactions may occur that produce significant amounts of products which must be contained and treated. The APOLLO program was developed to assist in predicting the composition of the gases that are formed. Although the development of this program was directed toward ISV applications, it should be applicable tomore » other technologies where chemical reactions are of interest. This document presents the mathematical methodology of the APOLLO computer code. APOLLO is a computer code that calculates the products of both equilibrium and kinetic chemical reactions. The current version, written in FORTRAN, is readily adaptable to existing transport programs designed for the analysis of chemically reacting flow systems. Separate subroutines EQREACT and KIREACT for equilibrium ad kinetic chemistry respectively have been developed. A full detailed description of the numerical techniques used, which include both Lagrange multiplies and a third-order integrating scheme is presented. Sample test problems are presented and the results are in excellent agreement with those reported in the literature.« less

Slow Invariant Manifolds in Chemically Reactive Systems

NASA Astrophysics Data System (ADS)

Paolucci, Samuel; Powers, Joseph M.

2006-11-01

The scientific design of practical gas phase combustion devices has come to rely on the use of mathematical models which include detailed chemical kinetics. Such models intrinsically admit a wide range of scales which renders their accurate numerical approximation difficult. Over the past decade, rational strategies, such as Intrinsic Low Dimensional Manifolds (ILDM) or Computational Singular Perturbations (CSP), for equilibrating fast time scale events have been successfully developed, though their computation can be challenging and their accuracy in most cases uncertain. Both are approximations to the preferable slow invariant manifold which best describes how the system evolves in the long time limit. Strategies for computing the slow invariant manifold are examined, and results are presented for practical combustion systems.

Johnston Atoll Chemical Agent Disposal System (JACADS)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1990-06-01

This Final Second Supplemental Environmental Impact Statement (SSEIS) to the Johnston Atoll Chemical Agent Disposal System (JACADS) Environmental Impact Statement (EIS) assesses the effects of receiving, storing, and ultimately destructing the United States stockpile of lethal unitary chemical munitions currently stored in the Federal Republic of Germany (FRG) (European stockpile) at the Army's JACADS facility located on Johnston Atoll in the Pacific Ocean. This Final SSEIS addresses the effects of the following proposed European stockpile activities: the transport of the European stockpile from the territorial limit to Johnston Island, the unloading of munitions from transportation ships, the on-island munitions transportmore » and handling, on-island munitions storage, the disposal of munitions in the JACADS facility, the disposal of incineration wastes, and alternatives to the proposed action. This document also updates information in the 1983 EIS and the 1988 SEIS, as appropriate. 46 refs., 10 figs., 9 tabs.« less

Martian Meteorology: Determination of Large Scale Weather Patterns from Surface Measurements

NASA Technical Reports Server (NTRS)

Murphy, James R.; Haberle, Robert M.; Bridger, Alison F. C.

1998-01-01

We employed numerical modelling of the martian atmosphere, and our expertise in understanding martian atmospheric processes, to better understand the coupling between lower and upper atmosphere processes. One practical application of this work has been our involvement with the ongoing atmospheric aerobraking which the Mars Global Surveyor (MGS) spacecraft is currently undergoing at Mars. Dr. Murphy is currently a member of the Mars Global Surveyor (MGS) Aerobraking Atmospheric Advisory Group (AAG). He was asked to participate in this activity based upon his knowledge of martian atmospheric dynamical processes. Aerobraking is a process whereby a spacecraft, in an elliptical orbit, passes through the upper layers of the atmosphere (in this instance Mars). This passage through the atmosphere 'drags'upon the spacecraft, gradually reducing its orbital velocity. This has the effect, over time, of converting the elliptical orbit to a circular orbit, which is the desired mapping orbit for MGS. Carrying out aerobraking eliminates the need for carrying large amounts of fuel on the spacecraft to execute an engine burn to achieve the desired orbit. Eliminating the mass of the fuel reduces the cost of launch. Damage to one of MGS's solar panels shortly after launch has resulted in a less aggressive extended in time aerobraking phase which will not end until March, 1999. Phase I extended from Sept. 1997 through March 1998. During this time period, Dr. Murphy participated almost daily in the AAG meetings, and beginning in December 1997 lead the meeting several times per week. The leader of each of the daily AAG meetings took the results of that meeting (current state of the atmosphere, identification of any time trends or spatial patterns in upper atmosphere densities, etc.) forward to the Aerobraking Planning Group (APG) meeting, at which time the decision was made to not change MGS orbit, to lower the orbit to reach higher densities (greater 'drag'), or raise the orbit to avoid

[Interview study on autonomous chemical management system and the contribution of occupational health specialists in companies].

PubMed

Mori, Koji; Takebayashi, Toru

2004-09-01

Under the circumstance that autonomous risk management for chemicals is required in Japan, it is necessary to define fundamental steps for developing chemical management system that are applicable in various types of companies and to understand the effective contribution of chemical or occupational health specialists to the system. For the purposes, we conducted interviews with companies which have an advanced chemical management system in Japan. As the result, each company had a certain policy about detailedness level of collected hazard and exposure information, and also had an efficient risk management system to ensure workers' health in depending on the business type and situations. Moreover, it was commonly observed that the specialists played major roles in developing tools for risk assessment and control, and then business lines led execution of the risk management with their supports. Based on the interviews, we showed a hypothesis of basic steps in introducing autonomous chemical risk management system at the workplaces. It is necessary to verify the hypothesis and to develop a simple system that is applicable to middle or small size companies as the next step.

Chemical sensing system for classification of minelike objects by explosives detection

NASA Astrophysics Data System (ADS)

Chambers, William B.; Rodacy, Philip J.; Jones, Edwin E.; Gomez, Bernard J.; Woodfin, Ronald L.

1998-09-01

Sandia National Laboratories has conducted research in chemical sensing and analysis of explosives for many years. Recently, that experience has been directed towards detecting mines and unexploded ordnance (UXO) by sensing the low-level explosive signatures associated with these objects. Our focus has been on the classification of UXO in shallow water and anti-personnel/anti tank mines on land. The objective of this work is to develop a field portable chemical sensing system which can be used to examine mine-like objects (MLO) to determine whether there are explosive molecules associated with the MLO. Two sampling subsystems have been designed, one for water collection and one for soil/vapor sampling. The water sampler utilizes a flow-through chemical adsorbent canister to extract and concentrate the explosive molecules. Explosive molecules are thermally desorbed from the concentrator and trapped in a focusing stage for rapid desorption into an ion-mobility spectrometer (IMS). We will describe a prototype system which consists of a sampler, concentrator-focuser, and detector. The soil sampler employs a light-weight probe for extracting and concentrating explosive vapor from the soil in the vicinity of an MLO. The chemical sensing system is capable of sub-part-per-billion detection of TNT and related explosive munition compounds. We will present the results of field and laboratory tests on buried landmines, which demonstrate our ability to detect the explosive signatures associated with these objects.

Improving integrative searching of systems chemical biology data using semantic annotation.

PubMed

Chen, Bin; Ding, Ying; Wild, David J

2012-03-08

Systems chemical biology and chemogenomics are considered critical, integrative disciplines in modern biomedical research, but require data mining of large, integrated, heterogeneous datasets from chemistry and biology. We previously developed an RDF-based resource called Chem2Bio2RDF that enabled querying of such data using the SPARQL query language. Whilst this work has proved useful in its own right as one of the first major resources in these disciplines, its utility could be greatly improved by the application of an ontology for annotation of the nodes and edges in the RDF graph, enabling a much richer range of semantic queries to be issued. We developed a generalized chemogenomics and systems chemical biology OWL ontology called Chem2Bio2OWL that describes the semantics of chemical compounds, drugs, protein targets, pathways, genes, diseases and side-effects, and the relationships between them. The ontology also includes data provenance. We used it to annotate our Chem2Bio2RDF dataset, making it a rich semantic resource. Through a series of scientific case studies we demonstrate how this (i) simplifies the process of building SPARQL queries, (ii) enables useful new kinds of queries on the data and (iii) makes possible intelligent reasoning and semantic graph mining in chemogenomics and systems chemical biology. Chem2Bio2OWL is available at http://chem2bio2rdf.org/owl. The document is available at http://chem2bio2owl.wikispaces.com.

Performance metrics for the evaluation of hyperspectral chemical identification systems

NASA Astrophysics Data System (ADS)

Truslow, Eric; Golowich, Steven; Manolakis, Dimitris; Ingle, Vinay

2016-02-01

Remote sensing of chemical vapor plumes is a difficult but important task for many military and civilian applications. Hyperspectral sensors operating in the long-wave infrared regime have well-demonstrated detection capabilities. However, the identification of a plume's chemical constituents, based on a chemical library, is a multiple hypothesis testing problem which standard detection metrics do not fully describe. We propose using an additional performance metric for identification based on the so-called Dice index. Our approach partitions and weights a confusion matrix to develop both the standard detection metrics and identification metric. Using the proposed metrics, we demonstrate that the intuitive system design of a detector bank followed by an identifier is indeed justified when incorporating performance information beyond the standard detection metrics.

A CRF-based system for recognizing chemical entity mentions (CEMs) in biomedical literature

PubMed Central

2015-01-01

Background In order to improve information access on chemical compounds and drugs (chemical entities) described in text repositories, it is very crucial to be able to identify chemical entity mentions (CEMs) automatically within text. The CHEMDNER challenge in BioCreative IV was specially designed to promote the implementation of corresponding systems that are able to detect mentions of chemical compounds and drugs, which has two subtasks: CDI (Chemical Document Indexing) and CEM. Results Our system processing pipeline consists of three major components: pre-processing (sentence detection, tokenization), recognition (CRF-based approach), and post-processing (rule-based approach and format conversion). In our post-challenge system, the cost parameter in CRF model was optimized by 10-fold cross validation with grid search, and word representations feature induced by Brown clustering method was introduced. For the CEM subtask, our official runs were ranked in top position by obtaining maximum 88.79% precision, 69.08% recall and 77.70% balanced F-measure, which were improved further to 88.43% precision, 76.48% recall and 82.02% balanced F-measure in our post-challenge system. Conclusions In our system, instead of extracting a CEM as a whole, we regarded it as a sequence labeling problem. Though our current system has much room for improvement, our system is valuable in showing that the performance in term of balanced F-measure can be improved largely by utilizing large amounts of relatively inexpensive un-annotated PubMed abstracts and optimizing the cost parameter in CRF model. From our practice and lessons, if one directly utilizes some open-source natural language processing (NLP) toolkits, such as OpenNLP, Standford CoreNLP, false positive (FP) rate may be very high. It is better to develop some additional rules to minimize the FP rate if one does not want to re-train the related models. Our CEM recognition system is available at: http

A multi-scaled approach for simulating chemical reaction systems.

PubMed

Burrage, Kevin; Tian, Tianhai; Burrage, Pamela

2004-01-01

In this paper we give an overview of some very recent work, as well as presenting a new approach, on the stochastic simulation of multi-scaled systems involving chemical reactions. In many biological systems (such as genetic regulation and cellular dynamics) there is a mix between small numbers of key regulatory proteins, and medium and large numbers of molecules. In addition, it is important to be able to follow the trajectories of individual molecules by taking proper account of the randomness inherent in such a system. We describe different types of simulation techniques (including the stochastic simulation algorithm, Poisson Runge-Kutta methods and the balanced Euler method) for treating simulations in the three different reaction regimes: slow, medium and fast. We then review some recent techniques on the treatment of coupled slow and fast reactions for stochastic chemical kinetics and present a new approach which couples the three regimes mentioned above. We then apply this approach to a biologically inspired problem involving the expression and activity of LacZ and LacY proteins in E. coli, and conclude with a discussion on the significance of this work. Copyright 2004 Elsevier Ltd.

33 CFR 149.416 - What are the requirements for a dry chemical fire suppression system?

Code of Federal Regulations, 2010 CFR

2010-07-01

... the requirements for a dry chemical fire suppression system? Each natural gas deepwater port must be... dry chemical fire suppression system? 149.416 Section 149.416 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: DESIGN, CONSTRUCTION...

Direct Monte Carlo simulation of chemical reaction systems: Simple bimolecular reactions

NASA Astrophysics Data System (ADS)

Piersall, Shannon D.; Anderson, James B.

1991-07-01

In applications to several simple reaction systems we have explored a ``direct simulation'' method for predicting and understanding the behavior of gas phase chemical reaction systems. This Monte Carlo method, originated by Bird, has been found remarkably successful in treating a number of difficult problems in rarefied dynamics. Extension to chemical reactions offers a powerful tool for treating reaction systems with nonthermal distributions, with coupled gas-dynamic and reaction effects, with emission and adsorption of radiation, and with many other effects difficult to treat in any other way. The usual differential equations of chemical kinetics are eliminated. For a bimolecular reaction of the type A+B→C+D with a rate sufficiently low to allow a continued thermal equilibrium of reactants we find that direct simulation reproduces the expected second order kinetics. Simulations for a range of temperatures yield the activation energies expected for the reaction models specified. For faster reactions under conditions leading to a depletion of energetic reactant species, the expected slowing of reaction rates and departures from equilibrium distributions are observed. The minimum sample sizes required for adequate simulations are as low as 1000 molecules for these cases. The calculations are found to be simple and straightforward for the homogeneous systems considered. Although computation requirements may be excessively high for very slow reactions, they are reasonably low for fast reactions, for which nonequilibrium effects are most important.

Pulse-density modulation control of chemical oscillation far from equilibrium in a droplet open-reactor system

PubMed Central

Sugiura, Haruka; Ito, Manami; Okuaki, Tomoya; Mori, Yoshihito; Kitahata, Hiroyuki; Takinoue, Masahiro

2016-01-01

The design, construction and control of artificial self-organized systems modelled on dynamical behaviours of living systems are important issues in biologically inspired engineering. Such systems are usually based on complex reaction dynamics far from equilibrium; therefore, the control of non-equilibrium conditions is required. Here we report a droplet open-reactor system, based on droplet fusion and fission, that achieves dynamical control over chemical fluxes into/out of the reactor for chemical reactions far from equilibrium. We mathematically reveal that the control mechanism is formulated as pulse-density modulation control of the fusion–fission timing. We produce the droplet open-reactor system using microfluidic technologies and then perform external control and autonomous feedback control over autocatalytic chemical oscillation reactions far from equilibrium. We believe that this system will be valuable for the dynamical control over self-organized phenomena far from equilibrium in chemical and biomedical studies. PMID:26786848

Pulse-density modulation control of chemical oscillation far from equilibrium in a droplet open-reactor system.

PubMed

Sugiura, Haruka; Ito, Manami; Okuaki, Tomoya; Mori, Yoshihito; Kitahata, Hiroyuki; Takinoue, Masahiro

2016-01-20

The design, construction and control of artificial self-organized systems modelled on dynamical behaviours of living systems are important issues in biologically inspired engineering. Such systems are usually based on complex reaction dynamics far from equilibrium; therefore, the control of non-equilibrium conditions is required. Here we report a droplet open-reactor system, based on droplet fusion and fission, that achieves dynamical control over chemical fluxes into/out of the reactor for chemical reactions far from equilibrium. We mathematically reveal that the control mechanism is formulated as pulse-density modulation control of the fusion-fission timing. We produce the droplet open-reactor system using microfluidic technologies and then perform external control and autonomous feedback control over autocatalytic chemical oscillation reactions far from equilibrium. We believe that this system will be valuable for the dynamical control over self-organized phenomena far from equilibrium in chemical and biomedical studies.

Application of chemical dehumidification system to a roof fan house at Michoud Assembly Facility at New Orleans, Louisiana

NASA Technical Reports Server (NTRS)

1976-01-01

The feasibility of a chemical dehumidification system to reduce the energy consumption associated with dehumidification of the chilled air is assessed. A comparative energy consumption and cost analysis of the chemical dehumidification and existing systems and the savings offered by the proposed chemical dehumidification system over the existing air washer-reheat system are presented.

INSPACE CHEMICAL PROPULSION SYSTEMS AT NASA's MARSHALL SPACE FLIGHT CENTER: HERITAGE AND CAPABILITIES

NASA Technical Reports Server (NTRS)

McRight, P. S.; Sheehy, J. A.; Blevins, J. A.

2005-01-01

NASA s Marshall Space Flight Center (MSFC) is well known for its contributions to large ascent propulsion systems such as the Saturn V rocket and the Space Shuttle external tank, solid rocket boosters, and main engines. This paper highlights a lesser known but very rich side of MSFC-its heritage in the development of in-space chemical propulsion systems and its current capabilities for spacecraft propulsion system development and chemical propulsion research. The historical narrative describes the flight development activities associated with upper stage main propulsion systems such as the Saturn S-IVB as well as orbital maneuvering and reaction control systems such as the S-IVB auxiliary propulsion system, the Skylab thruster attitude control system, and many more recent activities such as Chandra, the Demonstration of Automated Rendezvous Technology (DART), X-37, the X-38 de-orbit propulsion system, the Interim Control Module, the US Propulsion Module, and multiple technology development activities. This paper also highlights MSFC s advanced chemical propulsion research capabilities, including an overview of the center s Propulsion Systems Department and ongoing activities. The authors highlight near-term and long-term technology challenges to which MSFC research and system development competencies are relevant. This paper concludes by assessing the value of the full range of aforementioned activities, strengths, and capabilities in light of NASA s exploration missions.

Aerodynamic heating on AFE due to nonequilibrium flow with variable entropy at boundary layer edge

NASA Technical Reports Server (NTRS)

Ting, P. C.; Rochelle, W. C.; Bouslog, S. A.; Tam, L. T.; Scott, C. D.; Curry, D. M.

1991-01-01

A method of predicting the aerobrake aerothermodynamic environment on the NASA Aeroassist Flight Experiment (AFE) vehicle is described. Results of a three dimensional inviscid nonequilibrium solution are used as input to an axisymmetric nonequilibrium boundary layer program to predict AFE convective heating rates. Inviscid flow field properties are obtained from the Euler option of the Viscous Reacting Flow (VRFLO) code at the boundary layer edge. Heating rates on the AFE surface are generated with the Boundary Layer Integral Matrix Procedure (BLIMP) code for a partially catalytic surface composed of Reusable Surface Insulation (RSI) times. The 1864 kg AFE will fly an aerobraking trajectory, simulating return from geosynchronous Earth orbit, with a 75 km perigee and a 10 km/sec entry velocity. Results of this analysis will provide principal investigators and thermal analysts with aeroheating environments to perform experiment and thermal protection system design.

Application of a reversible chemical reaction system to solar thermal power plants

NASA Technical Reports Server (NTRS)

Hanseth, E. J.; Won, Y. S.; Seibowitz, L. P.

1980-01-01

Three distributed dish solar thermal power systems using various applications of SO2/SO3 chemical energy storage and transport technology were comparatively assessed. Each system features various roles for the chemical system: (1) energy storage only, (2) energy transport, or (3) energy transport and storage. These three systems were also compared with the dish-Stirling, using electrical transport and battery storage, and the central receiver Rankine system, with thermal storage, to determine the relative merit of plants employing a thermochemical system. As an assessment criterion, the busbar energy costs were compared. Separate but comparable solar energy cost computer codes were used for distributed receiver and central receiver systems. Calculations were performed for capacity factors ranging from 0.4 to 0.8. The results indicate that SO2/SO3 technology has the potential to be more cost effective in transporting the collected energy than in storing the energy for the storage capacity range studied (2-15 hours)

Large-Area Chemical and Biological Decontamination Using a High Energy Arc Lamp (HEAL) System.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duty, Chad E; Smith, Rob R; Vass, Arpad Alexander

2008-01-01

Methods for quickly decontaminating large areas exposed to chemical and biological (CB) warfare agents can present significant logistical, manpower, and waste management challenges. Oak Ridge National Laboratory (ORNL) is pursuing an alternate method to decompose CB agents without the use of toxic chemicals or other potentially harmful substances. This process uses a high energy arc lamp (HEAL) system to photochemically decompose CB agents over large areas (12 m2). Preliminary tests indicate that more than 5 decades (99.999%) of an Anthrax spore simulant (Bacillus globigii) were killed in less than 7 seconds of exposure to the HEAL system. When combined withmore » a catalyst material (TiO2) the HEAL system was also effective against a chemical agent simulant, diisopropyl methyl phosphonate (DIMP). These results demonstrate the feasibility of a rapid, large-area chemical and biological decontamination method that does not require toxic or corrosive reagents or generate hazardous wastes.« less

[Advances in novel carrier systems of chemical constituents from spice volatile oils].

PubMed

Zhang, Jia-jia; Zhu, Yuan; Yu, Jiang-nan; Xu, Xi-ming

2015-10-01

Recent years, chemical constituents from spice volatile oils have gained worldwide concern owing to its multiple pharmacological effects and safety for using as the natural antibacterial agents. However, their poor dissolution, strong volatility, serious irritation, weak stability, easy oxidation and low bioavailability characteristics are the major obstacle in the preparation of effective oral formulation and practical application. Therefore, there is an urgent need to select a novel carrier system that can delivery the chemical constituents from spice volatile oils more efficiently with improving their stability as well as alleviating the irritation, and develop the functional food, health products and even medicine for exerting their pharmacological effects, which also is the focus and nodus of the research on their application. This review presents recent systematic studies on their novel carrier systems, including cyclodextrin inclusion complex, liposomes, nanoemulsions, nanoparticles, solid dispersion and so on, and summarizes the characteristics, application range and problems of each novel carrier systems, in order to provide some beneficial thoughts in further developing new products of chemical constituents from spice volatile oils.

Propellant management for low thrust chemical propulsion systems

NASA Technical Reports Server (NTRS)

Hamlyn, K. M.; Dergance, R. H.; Aydelott, J. C.

1981-01-01

Low-thrust chemical propulsion systems (LTPS) will be required for orbital transfer of large space systems (LSS). The work reported in this paper was conducted to determine the propellant requirements, preferred propellant management technique, and propulsion system sizes for the LTPS. Propellants were liquid oxygen (LO2) combined with liquid hydrogen (LH2), liquid methane or kerosene. Thrust levels of 100, 500, and 1000 lbf were combined with 1, 4, and 8 perigee burns for transfer from low earth orbit to geosynchronous earth orbit. This matrix of systems was evaluated with a multilayer insulation (MLI) or a spray-on-foam insulation. Vehicle sizing results indicate that a toroidal tank configuration is needed for the LO2/LH2 system. Multiple perigee burns and MLI allow far superior LSS payload capability. Propellant settling, combined with a single screen device, was found to be the lightest and least complex propellant management technique.

40 CFR 63.149 - Control requirements for certain liquid streams in open systems within a chemical manufacturing...

Code of Federal Regulations, 2010 CFR

2010-07-01

... streams in open systems within a chemical manufacturing process unit. 63.149 Section 63.149 Protection of... open systems within a chemical manufacturing process unit. (a) The owner or operator shall comply with... Air Pollutants From the Synthetic Organic Chemical Manufacturing Industry for Process Vents, Storage...

A Selective-Echo Method for Chemical-Shift Imaging of Two-Component Systems

NASA Astrophysics Data System (ADS)

Gerald, Rex E., II; Krasavin, Anatoly O.; Botto, Robert E.

A simple and effective method for selectively imaging either one of two chemical species in a two-component system is presented and demonstrated experimentally. The pulse sequence employed, selective- echo chemical- shift imaging (SECSI), is a hybrid (frequency-selective/ T1-contrast) technique that is executed in a short period of time, utilizes the full Boltzmann magnetization of each chemical species to form the corresponding image, and requires only hard pulses of quadrature phase. This approach provides a direct and unambiguous representation of the spatial distribution of the two chemical species. In addition, the performance characteristics and the advantages of the SECSI sequence are compared on a common basis to those of other pulse sequences.

An investigation of interurban variations in the chemical composition and mutagenic activity of airborne particulate organic matter using an integrated chemical class/bioassay system

NASA Astrophysics Data System (ADS)

Butler, J. P.; Kneip, T. J.; Daisey, J. M.

Previous investigations in this laboratory have demonstrated that the mutagenic activities of extractable particulate organic matter (EOM) from cities which differ in their principal fuels and meteorology can vary significantly. To gain a better understanding of these interurban variations, an Integrated Chemical Class/Biological Screening System was developed and used for a more detailed examination of differences in the chemical composition and mutagenic activity of EOM. The screening system involved coupling in situ Ames mutagenicity determinations on high performance thin layer chromatography (HPTLC) plates with class specific chemical analyses on a second set of plates. The system was used to screen for mutagenic activity and selected chemical classes (including PAH, nitro-PAH, phenols, carboxylic acids, carbonyls, aza-arenes and alkylating agents) in EOM from the following sites: New York City; Elizabeth, N.J.; Mexico City; Beijing, China; Philadelphia, PA; and the Caldecott Tunnel (CA). The results of this study demonstrated mutagenic activity and chemical compositional differences in HPTLC subfractions of particulate organic matter from these cities and from the Caldecott Tunnel. The greatest interurban differences in chemical classes were observed for the phenols, carbonyl compounds and alkylating agents. Interurban variations in mutagenic activities were greatest for EOM subfractions of intermediate polarity. These differences are probably related to interurban differences in the fuels used, types of sources and atmospheric conditions. The relationships between these variables are not well understood at present.

CFD applications in hypersonic flight

NASA Technical Reports Server (NTRS)

Edwards, T. A.

1992-01-01

Design studies are underway for a variety of hypersonic flight vehicles. The National Aero-Space Plane will provide a reusable, single-stage-to-orbit capability for routine access to low earth orbit. Flight-capable satellites will dip into the atmosphere to maneuver to new orbits, while planetary probes will decelerate at their destination by atmospheric aerobraking. To supplement limited experimental capabilities in the hypersonic regime, CFD is being used to analyze the flow about these configurations. The governing equations include fluid dynamic as well as chemical species equations, which are solved with robust upwind differencing schemes. Examples of CFD applications to hypersonic vehicles suggest an important role this technology will play in the development of future aerospace systems. The computational resources needed to obtain solutions are large, but various strategies are being exploited to reduce the time required for complete vehicle simulations.

Mars Molniya Orbit Atmospheric Resource Mining

NASA Technical Reports Server (NTRS)

Mueller, Robert P.; Braun, Robert D.; Sibille, Laurent; Sforzo, Brandon; Gonyea, Keir; Ali, Hisham

2016-01-01

This NIAC (NASA Advanced Innovative Concepts) work will focus on Mars and will build on previous efforts at analyzing atmospheric mining at Earth and the outer solar system. Spacecraft systems concepts will be evaluated and traded, to assess feasibility. However the study will primarily examine the architecture and associated missions to explore the closure, constraints and critical parameters through sensitivity studies. The Mars atmosphere consists of 95.5 percent CO2 gas which can be converted to methane fuel (CH4) and Oxidizer (O2) for chemical rocket propulsion, if hydrogen is transported from electrolyzed water on the Mars surface or from Earth. By using a highly elliptical Mars Molniya style orbit, the CO2 atmosphere can be scooped, ram-compressed and stored while the spacecraft dips into the Mars atmosphere at periapsis. Successive orbits result in additional scooping of CO2 gas, which also serves to aerobrake the spacecraft, resulting in a decaying Molniya orbit.

Chemical evolution of primitive solar system bodies

NASA Technical Reports Server (NTRS)

Oro, J.; Mills, T.

1989-01-01

Observations on organic molecules and compounds containing biogenic elements in the interstellar medium and in the primitive bodies of the solar system are reviewed. The discovery of phosphorus molecular species in dense interstellar clouds, the existence of organic ions in the dust and gas phase of the comas of Comet Halley, and the presence of presolar, deuterium-hydrogen ratios in the amino acids of carbonaceous chondrites are discussed. The relationships between comets, dark asteroids, and carbonaceous chondrites are examined. Also, consideration is given to the chemical evolution of Titan, the primitive earth, and early Mars.

Portable chemical detection system with intergrated preconcentrator

DOEpatents

Baumann, Mark J.; Brusseau, Charles A.; Hannum, David W.; Linker, Kevin L.

2005-12-27

A portable system for the detection of chemical particles such as explosive residue utilizes a metal fiber substrate that may either be swiped over a subject or placed in a holder in a collection module which can shoot a jet of gas at the subject to dislodge residue, and then draw the air containing the residue into the substrate. The holder is then placed in a detection module, which resistively heats the substrate to evolve the particles, and provides a gas flow to move the particles to a miniature detector in the module.

Ring system-based chemical graph generation for de novo molecular design

NASA Astrophysics Data System (ADS)

Miyao, Tomoyuki; Kaneko, Hiromasa; Funatsu, Kimito

2016-05-01

Generating chemical graphs in silico by combining building blocks is important and fundamental in virtual combinatorial chemistry. A premise in this area is that generated structures should be irredundant as well as exhaustive. In this study, we develop structure generation algorithms regarding combining ring systems as well as atom fragments. The proposed algorithms consist of three parts. First, chemical structures are generated through a canonical construction path. During structure generation, ring systems can be treated as reduced graphs having fewer vertices than those in the original ones. Second, diversified structures are generated by a simple rule-based generation algorithm. Third, the number of structures to be generated can be estimated with adequate accuracy without actual exhaustive generation. The proposed algorithms were implemented in structure generator Molgilla. As a practical application, Molgilla generated chemical structures mimicking rosiglitazone in terms of a two dimensional pharmacophore pattern. The strength of the algorithms lies in simplicity and flexibility. Therefore, they may be applied to various computer programs regarding structure generation by combining building blocks.

Development and testing of dry chemicals in advanced extinguishing systems for jet engine nacelle fires

NASA Technical Reports Server (NTRS)

Altman, R. L.; Ling, A. C. (Editor); Mayer, L. A.; Myronik, D. J.

1979-01-01

The effectiveness of dry chemical in extinguishing and delaying reignition of fires resulting from hydrocarbon fuel leaking onto heated surfaces such as can occur in jet engine nacelles is studied. The commercial fire extinguishant dry chemical tried are sodium and potassium bicarbonate, carbonate, chloride, carbamate (Monnex), metal halogen, and metal hydroxycarbonate compounds. Synthetic and preparative procedures for new materials developed, a new concept of fire control by dry chemical agents, descriptions of experiment assemblages to test dry chemical fire extinguishant efficiencies in controlling fuel fires initiated by hot surfaces, comparative testing data for more than 25 chemical systems in a 'static' assemblage with no air flow across the heated surface, and similar comparative data for more than ten compounds in a dynamic system with air flows up to 350 ft/sec are presented.

[Chemicals toxic to the olfactory system. Analysis and description].

PubMed

Norès, J M; Biacabe, B; Bonfils, P

2000-10-28

AN IMPORTANT PROBLEM: Occupational exposure to chemical products can have toxic effects on the olfactory system. An important number of patients have experienced olfactory disorders subsequent to the development of the chemical industry and atmospheric pollution. EPIDEMIOLOGY DATA: Straightforward data are difficult to collect because several cofactors other than the toxic product are involved. Two lists of toxic products can be made. The first list includes products for which scientific data is available and the second products for which data is lacking. Olfactory tests also differ between authors and countries. TWO TYPES OF TOXICITY: Acute, accidental toxicity is evidenced by the lesions caused by inhalation of high-doses of strongly toxic agents. Chronic intoxication caused by lower concentrations of these inhaled agents does not produce a trigeminal reflex leading to a modified respiratory rate reducing the airborne aggression. APPROXIMATIONS: Clinical data describing the olfactory toxicity of certain industrial and chemical compounds are very significant but often cannot prove a cause and effect relationship. Data obtained with experimental models in rodents are difficult to extrapolate to humans.

Discourse for slide presentation: An overview of chemical detection systems

NASA Technical Reports Server (NTRS)

Peters, Randy Alan; Galen, Theodore J.; Pierson, Duane L.

1990-01-01

A brief overview of some of the analytical techniques currently used in monitoring and analyzing permanent gases and selected volatile organic compound in air are presented. Some of the analytical considerations in developing a specific method are discussed. Four broad groups of hardware are discussed: compound class specific personal monitors, gas chromatographic systems, infrared spectroscopic systems, and mass spectrometric residual gas analyzer systems. Three types of detectors are also discussed: catalytic sensor based systems, photoionization detectors, and wet or dry chemical reagent systems. Under gas chromatograph based systems five detector systems used in combination with a GC are covered: thermal conductivity detectors, photoionization detectors, Fourier transform infrared spectrophotometric systems, quadrapole mass spectrometric systems, and a relatively recent development, a surface acoustic wave vapor detector.

Improved Mars Upper Atmosphere Climatology

NASA Technical Reports Server (NTRS)

Bougher, S. W.

2004-01-01

The detailed characterization of the Mars upper atmosphere is important for future Mars aerobraking activities. Solar cycle, seasonal, and dust trends (climate) as well as planetary wave activity (weather) are crucial to quantify in order to improve our ability to reasonably depict the state of the Mars upper atmosphere over time. To date, our best information is found in the Mars Global Surveyor (MGS) Accelerometer (ACC) database collected during Phase 1 (Ls = 184 - 300; F10.7 = 70 - 90) and Phase 2 (Ls = 30 - 90; F10.7 = 90 - 150) of aerobraking. This database (100 - 170 km) consists of thermospheric densities, temperatures, and scale heights, providing our best constraints for exercising the coupled Mars General Circulation Model (MGCM) and the Mars Thermospheric General Circulation Model (MTGCM). The Planetary Data System (PDS) contains level 0 and 2 MGS Accelerometer data, corresponding to atmospheric densities along the orbit track. Level 3 products (densities, temperatures, and scale heights at constant altitudes) are also available in the PDS. These datasets provide the primary model constraints for the new MGCM-MTGCM simulations summarized in this report. Our strategy for improving the characterization of the Mars upper atmospheres using these models has been three-fold : (a) to conduct data-model comparisons using the latest MGS data covering limited climatic and weather conditions at Mars, (b) to upgrade the 15-micron cooling and near-IR heating rates in the MGCM and MTGCM codes for ad- dressing climatic variations (solar cycle and seasonal) important in linking the lower and upper atmospheres (including migrating tides), and (c) to exercise the detailed coupled MGCM and MTGCM codes to capture and diagnose the planetary wave (migrating plus non-migrating tidal) features throughout the Mars year. Products from this new suite of MGCM-MTGCM coupled simulations are being used to improve our predictions of the structure of the Mars upper atmosphere for the

Reliability Evaluation and Improvement Approach of Chemical Production Man - Machine - Environment System

NASA Astrophysics Data System (ADS)

Miao, Yongchun; Kang, Rongxue; Chen, Xuefeng

2017-12-01

In recent years, with the gradual extension of reliability research, the study of production system reliability has become the hot topic in various industries. Man-machine-environment system is a complex system composed of human factors, machinery equipment and environment. The reliability of individual factor must be analyzed in order to gradually transit to the research of three-factor reliability. Meanwhile, the dynamic relationship among man-machine-environment should be considered to establish an effective blurry evaluation mechanism to truly and effectively analyze the reliability of such systems. In this paper, based on the system engineering, fuzzy theory, reliability theory, human error, environmental impact and machinery equipment failure theory, the reliabilities of human factor, machinery equipment and environment of some chemical production system were studied by the method of fuzzy evaluation. At last, the reliability of man-machine-environment system was calculated to obtain the weighted result, which indicated that the reliability value of this chemical production system was 86.29. Through the given evaluation domain it can be seen that the reliability of man-machine-environment integrated system is in a good status, and the effective measures for further improvement were proposed according to the fuzzy calculation results.

Porous TiO₂-Based Gas Sensors for Cyber Chemical Systems to Provide Security and Medical Diagnosis.

PubMed

Galstyan, Vardan

2017-12-19

Gas sensors play an important role in our life, providing control and security of technical processes, environment, transportation and healthcare. Consequently, the development of high performance gas sensor devices is the subject of intense research. TiO₂, with its excellent physical and chemical properties, is a very attractive material for the fabrication of chemical sensors. Meanwhile, the emerging technologies are focused on the fabrication of more flexible and smart systems for precise monitoring and diagnosis in real-time. The proposed cyber chemical systems in this paper are based on the integration of cyber elements with the chemical sensor devices. These systems may have a crucial effect on the environmental and industrial safety, control of carriage of dangerous goods and medicine. This review highlights the recent developments on fabrication of porous TiO₂-based chemical gas sensors for their application in cyber chemical system showing the convenience and feasibility of such a model to provide the security and to perform the diagnostics. The most of reports have demonstrated that the fabrication of doped, mixed and composite structures based on porous TiO₂ may drastically improve its sensing performance. In addition, each component has its unique effect on the sensing properties of material.

Chemical shift-based identification of monosaccharide spin-systems with NMR spectroscopy to complement untargeted glycomics.

PubMed

Klukowski, Piotr; Schubert, Mario

2018-06-15

A better understanding of oligosaccharides and their wide-ranging functions in almost every aspect of biology and medicine promises to uncover hidden layers of biology and will support the development of better therapies. Elucidating the chemical structure of an unknown oligosaccharide is still a challenge. Efficient tools are required for non-targeted glycomics. Chemical shifts are a rich source of information about the topology and configuration of biomolecules, whose potential is however not fully explored for oligosaccharides. We hypothesize that the chemical shifts of each monosaccharide are unique for each saccharide type with a certain linkage pattern, so that correlated data measured by NMR spectroscopy can be used to identify the chemical nature of a carbohydrate. We present here an efficient search algorithm, GlycoNMRSearch, that matches either a subset or the entire set of chemical shifts of an unidentified monosaccharide spin system to all spin systems in an NMR database. The search output is much more precise than earlier search functions and highly similar matches suggest the chemical structure of the spin system within the oligosaccharide. Thus searching for connected chemical shift correlations within all electronically available NMR data of oligosaccharides is a very efficient way of identifying the chemical structure of unknown oligosaccharides. With an improved database in the future, GlycoNMRSearch will be even more efficient deducing chemical structures of oligosaccharides and there is a high chance that it becomes an indispensable technique for glycomics. The search algorithm presented here, together with a graphical user interface, is available at http://glyconmrsearch.santos.pwr.edu.pl. Supplementary data are available at Bioinformatics online.

[Chemical Potentials of Hydrothermal Systems and Formation of Coupled Modular Metabolic Pathways].

PubMed

Marakushev, S A; Belonogova, O V

2015-01-01

According to Gibbs J.W. the number of independent components is the least number of those chemical constituents, by combining which the compositions of all possible phases in the system can be obtained, and at the first stages of development of the primary metabolism of the three-component system C-H-O different hydrocarbons and molecular hydrogen were used as an energy source for, it. In the Archean hydrothermal conditions under the action of the phosphorus chemical potential the C-H-O system was transformed into a four-component system C-H-O-P setting up a gluconeogenic system, which became the basis of power supply for a protometabolism, and formation of a new cycle of CO2 fixation (reductive pentose phosphate pathway). It is shown that parageneses (association) of certain substances permitted the modular constructions of the central metabolism of the system C-H-O-P and the formed modules appear in association with each other in certain physicochemical hydrothermal conditions. Malate, oxaloacetate, pyruvate and phosphoenolpyruvate exhibit a turnstile-like mechanism of switching reaction directions.

Computer program determines chemical composition of physical system at equilibrium

NASA Technical Reports Server (NTRS)

Kwong, S. S.

1966-01-01

FORTRAN 4 digital computer program calculates equilibrium composition of complex, multiphase chemical systems. This is a free energy minimization method with solution of the problem reduced to mathematical operations, without concern for the chemistry involved. Also certain thermodynamic properties are determined as byproducts of the main calculations.

Materials Problems in Chemical Liquid-Propellant Rocket Systems

NASA Technical Reports Server (NTRS)

Gilbert, L. L.

1959-01-01

With the advent of the space age, new adjustments in technical thinking and engineering experience are necessary. There is an increasing and extensive interest in the utilization of materials for components to be used at temperatures ranging from -423 to over 3500 deg F. This paper presents a description of the materials problems associated with the various components of chemical liquid rocket systems. These components include cooled and uncooled thrust chambers, injectors, turbine drive systems, propellant tanks, and cryogenic propellant containers. In addition to materials limitations associated with these components, suggested research approaches for improving materials properties are made. Materials such as high-temperature alloys, cermets, carbides, nonferrous alloys, plastics, refractory metals, and porous materials are considered.

Orbital transfer vehicle concept definition and system analysis study, 1986. Volume 9: Study extension results

NASA Technical Reports Server (NTRS)

Kofal, Allen E.

1987-01-01

The purpose of this extension to the OTV Concept Definition and Systems Analysis Study was to improve the definition of the OTV Program that will be most beneficial to the nation in the 1995 to 2010 timeframe. The implications of the defined mission and defined launch vehicle are investigated. The key mission requirements identified for the Space Transportation Architecture Study (STAS) were established and reflect a need for early capability and more ambitious capability growth. The key technical objectives and related issues addressed are summarized. The analyses of selected areas including aerobrake design, proximity operations, and the balance of EVA and IVA operations used in the support of the OTV at the space-base were enhanced. Sensitivity studies were conducted to establish how the OTV program should be tailored to meet changing circumstances.

Stepwise Evolution of Nonliving to Living Chemical Systems

NASA Astrophysics Data System (ADS)

Lindahl, Paul A.

2004-08-01

Steps by which a nonliving chemical system could have transformed into a living system are described and discussed, assuming general features of Wächtershäuser's chemo-autotrophic surface theory of the origin of life. Environmental species such as CO2 and H2S are proposed to have reacted to form a quasi-steady state metal-bound intermediate (CH3-M) that slowly decayed into waste (CH4). Unpredictable dispersive reactions expanded the system to include surface-bound forms of the citric acid cycle intermediates (oxaloacetate --> citrate). Further reaction yielded an autocatalytic system in which raw materials are converted into the system at exponential rates. Combinatorial dispersive reactions that improved the performance of this system were automatically selected and incorporated into it. Systems evolved critical features of living systems (proteins, membranes, proteins, nucleic acids, etc.) using two related mechanisms called grafting and waste-conversion. Such living systems were transformed from less recognizable types (characterized by autocatalytic spreading, decentralization, poorly defined boundaries, etc.) into more recognizable ones (encapsulated by membranes, controlled by single-molecule genomes, etc.) that self-replicated by a cell division cycle and could evolve by the standard gene-based Darwinian mechanism. The resulting systems are viewed as having an autocatalytic network composed of three linked autocatalytic subreactions.

A Comparison of Transportation Systems for Human Missions to Mars

NASA Technical Reports Server (NTRS)

Thomas, Brent; Vaughan, Diane; Drake, Bret; Griffin, Brand; Woodcock, Gordon

2004-01-01

There are many ways to send humans to Mars. Credible technical reports can be traced to the 1950's. More recently, NASA has funded major studies that depict a broad variety of trajectories, technologies, stay times, and costs. Much of this data is still valid with direct application to today's exploration planning. This paper presents results comparing these studies with particular emphasis on the in-space transportation aspects of the mission. Specifically, comparisons are made on propulsion systems used for getting the crew and mission equipment from Earth orbit to Mars orbit, descending and ascending from the surface, and returning to Earth orbit. Areas of comparison for each of these phases include crew size, mission mass, propellant mass, delta v, specific impulse, transit time, surface stay time, aero-braking, and others. Data is analyzed to demonstrate either strong trends toward particular technologies or diverging solutions.

Dominant Overall Chemical Reaction in a Chlorine Trifluoride Silicon Nitrogen System at Atmospheric Pressure

NASA Astrophysics Data System (ADS)

Habuka, Hitoshi; Otsuka, Toru; Qu, Wei-Feng

1999-11-01

This study evaluates the overall chemical reaction in a chlorine trifluoride silicon nitrogen system at atmospheric pressure, based on the observation of the dominant chemical species in the gas phase using a quadrupole mass spectra analyzer coupled with a horizontal cold-wall single-wafer epitaxial reactor. Chlorine trifluoride gas etches the silicon surface, producing two major products, silicon tetrafluoride gas and chlorine gas, at room temperature and 530 K. The production of chlorosilanes was not observed in this study. The results obtained in this study indicate that the dominant overall chemical reaction in a chlorine trifluoride silicon nitrogen system is 3Si + 4ClF3 →3SiF4 ↑+ 2Cl2 ↑.

A realistic chemical system presenting a self-organized critical behavior

NASA Astrophysics Data System (ADS)

Gaveau, Bernard; Latrémolière, Daniel; Moreau, Michel

2003-04-01

We consider a realistic example of chemical system which presents self-organized criticality. We can study the kinetic equations analytically, and show that the conditions for self-organized criticality are satisfied. We find power relaxation laws for certain variables near the critical state, confirming the self-organized critical behavior.

Performance of two swine manure treatment systems on chemical composition and on the reduction of pathogens.

PubMed

Viancelli, A; Kunz, A; Steinmetz, R L R; Kich, J D; Souza, C K; Canal, C W; Coldebella, A; Esteves, P A; Barardi, C R M

2013-01-01

Swine effluents must be correctly handled to avoid negative environmental impacts. In this study, the profiles of two swine manure treatment systems were evaluated: a solid-liquid separation step, followed by an anaerobic reactor, and an aerobic step (System 1); and a biodigester followed by serial lagoons (System 2). Both systems were described by the assessment of chemical, bacterial and viral parameters. The results showed that in System 1, there was reduction of chemicals (COD, phosphorus, total Kjeldhal nitrogen - TKN - and NH(3)), total coliforms and Escherichia coli; however, the same reduction was not observed for Salmonella sp. Viral particles were significantly reduced but not totally eliminated from the effluent. In System 2, there was a reduction of chemicals, bacteria and viruses with no detection of Salmonella sp., circovirus, parvovirus, and torque teno virus in the effluent. The chemical results indicate that the treated effluent can be reused for cleaning swine facilities. However, the microbiological results show a need of additional treatment to achieve a complete inactivation for cases when direct contact with animals is required. Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical sensor system

NASA Technical Reports Server (NTRS)

Darrach, Murray R. (Inventor); Chutjian, Ara (Inventor)

2008-01-01

A chemical sensing apparatus and method for the detection of sub parts-per-trillion concentrations of molecules in a sample by optimizing electron utilization in the formation of negative ions is provided. A variety of media may be sampled including air, seawater, dry sediment, or undersea sediment. An electrostatic mirror is used to reduce the kinetic energy of an electron beam to zero or near-zero kinetic energy.

Network model of chemical-sensing system inspired by mouse taste buds.

PubMed

Tateno, Katsumi; Igarashi, Jun; Ohtubo, Yoshitaka; Nakada, Kazuki; Miki, Tsutomu; Yoshii, Kiyonori

2011-07-01

Taste buds endure extreme changes in temperature, pH, osmolarity, so on. Even though taste bud cells are replaced in a short span, they contribute to consistent taste reception. Each taste bud consists of about 50 cells whose networks are assumed to process taste information, at least preliminarily. In this article, we describe a neural network model inspired by the taste bud cells of mice. It consists of two layers. In the first layer, the chemical stimulus is transduced into an irregular spike train. The synchronization of the output impulses is induced by the irregular spike train at the second layer. These results show that the intensity of the chemical stimulus is encoded as the degree of the synchronization of output impulses. The present algorithms for signal processing result in a robust chemical-sensing system.

Space-based laser-powered orbital transfer vehicle (Project SLICK)

NASA Technical Reports Server (NTRS)

1988-01-01

The project SLICK (Space Laser Interorbital Cargo Kite) involves conceptual designs of reusable space-based laser-powered orbital transfer vehicle (LOTV) for ferrying 16,000 kg cargo primarily between low Earth orbit (LEO) and geosynchronous earth orbit (GEO). The power of LOTV is beamed by a single 32-MW solar-pumped iodide laser orbiting the Earth at an altitude of one Earth radius. The laser engine selected for the LOTV is based on a continuous-wave, steady-state propulsion scheme and uses an array of seven discrete plasmas in a flow of hydrogen propellant. Both all-propulsive and aerobraked LOTV configurations were analyzed and developed. The all-propulsive vehicle uses a rigid 11.5-m aperture primary mirror and its engine produces a thrust of 2000 N at a specific impulse of 1500 sec. For the LEO-to-GEO trip, the payload ratio, m(sub payload/m(sub propellant)+m(sub dry vehicle) = 1.19 and the trip time is about 6 days. The aerobraked version uses a lightweight, retractable wrapped-rib primary mirror which is folded for aerobraking and a 20-m-diameter inflatable-ballute aeroshield which is jettisoned after aeromaneuver. Lifecycle cost analysis shows that the aerobraked configuration may have an economic advantage over the all-propulsive configuration as long as the cost of launching the propellant to LEO is higher than about $500/kg in current dollars.

Mars-GRAM 2010: Additions and Resulting Improvements

NASA Technical Reports Server (NTRS)

Justh, Hilary L.; Burns, K. Lee

2013-01-01

The Mars Global Reference Atmospheric Model (Mars-GRAM) is an engineering-level atmospheric model widely used for diverse mission applications. Mars-GRAM has been utilized during previous aerobraking operations in the atmosphere of Mars. Mars-GRAM has also been used in the prediction and validation of Mars Pathfinder hypersonic aerodynamics, the aerothermodynamic and entry dynamics studies for Mars Polar Lander, the landing site selection process for the Mars Science Laboratory (MSL), the Mars Aerocapture System Study (MASS) as well as the Aerocapture Technology Assessment Group (TAG). Most recently, Mars-GRAM 2010 was used to develop the onboard atmospheric density estimator that is part of the Autonomous Aerobraking Development Plan. The most recent release of Mars-GRAM 2010 contains several changes including an update to Fortran 90/95 and the addition of adjustment factors. Following the completion of a comparison analysis between Mars-GRAM, Thermal Emission Spectrometer (TES), as well as Mars Global Surveyor (MGS), Mars Odyssey (ODY), and Mars Reconnaissance Orbiter (MRO) aerobraking density data, adjustment factors were added to Mars-GRAM 2010 that alter the input data from National Aeronautics and Space Administration (NASA) Ames Mars General Circulation Model (MGCM) and the University of Michigan Mars Thermospheric General Circulation Model (MTGCM) for the mapping year 0 user-controlled dust case. The addition of adjustment factors resolved the issue of previous versions of Mars-GRAM being less than realistic when used for sensitivity studies for mapping year 0 and large optical depth values, such as tau equal to 3. Mars-GRAM was evaluated at locations and times of TES limb observations and adjustment factors were determined. For altitudes above 80 km and below 135 km, Mars-GRAM (MTGCM) densities were compared to aerobraking densities measured by Mars Global Surveyor (MGS), Mars Odyssey (ODY), and Mars Reconnaissance Orbiter (MRO) to determine the adjustment

Chemical Leukoderma Associated with Methylphenidate Transdermal System: Data From the US Food and Drug Administration Adverse Event Reporting System.

PubMed

Cheng, Carmen; La Grenade, Lois; Diak, Ida-Lina; Brinker, Allen; Levin, Robert L

2017-01-01

To identify and characterize cases of chemical leukoderma, an underrecognized adverse event, associated with the methylphenidate transdermal system (MTS) reported to the US Food and Drug Administration Adverse Event Reporting System (FAERS). We searched the Food and Drug Administration Adverse Event Reporting System for reports of chemical leukoderma associated with MTS, received by the Food and Drug Administration from April 6, 2006 to December 23, 2014. We identified 51 cases of chemical leukoderma reported with the use of MTS. The median age was 11 years; 43 cases reported leukoderma at or near the application site only, and 7 reported leukoderma at other parts of the body in addition to the application site; 1 case did not provide enough information to confirm the affected site. The time to onset ranged from 2 months to 4 years after the initiation of MTS. MTS was discontinued in 31 cases. Thirteen patients were prescribed treatment for repigmentation. Three cases reported continued spread of leukoderma after MTS was discontinued. Nineteen cases were diagnosed as vitiligo, including 5 cases reporting histologic features consistent with vitiligo. Leukoderma was persistent in all cases. The median follow-up interval after the discontinuation of MTS in 23 cases was 14 months. As outlined in recent changes to the prescribing information for MTS, health care professionals need to be aware of the potential risk of chemical leukoderma caused by MTS, especially given that chemical leukoderma is often misdiagnosed as idiopathic vitiligo. MTS should be discontinued at the earliest sign of pigment loss and other treatment options considered. Published by Elsevier Inc.

Emergency Response System for Pollution Accidents in Chemical Industrial Parks, China

PubMed Central

Duan, Weili; He, Bin

2015-01-01

In addition to property damage and loss of lives, environment pollution, such as water pollution and air pollution caused by accidents in chemical industrial parks (CIPs) is a significant issue in China. An emergency response system (ERS) was therefore planned to properly and proactively cope with safety incidents including fire and explosions occurring in the CIPs in this study. Using a scenario analysis, the stages of emergency response were divided into three levels, after introducing the domino effect, and fundamental requirements of ERS design were confirmed. The framework of ERS was composed mainly of a monitoring system, an emergency command center, an action system, and a supporting system. On this basis, six main emergency rescue steps containing alarm receipt, emergency evaluation, launched corresponding emergency plans, emergency rescue actions, emergency recovery, and result evaluation and feedback were determined. Finally, an example from the XiaoHu Chemical Industrial Park (XHCIP) was presented to check on the integrality, reliability, and maneuverability of the ERS, and the result of the first emergency drill with this ERS indicated that the developed ERS can reduce delays, improve usage efficiency of resources, and raise emergency rescue efficiency. PMID:26184260

Emergency Response System for Pollution Accidents in Chemical Industrial Parks, China.

PubMed

Duan, Weili; He, Bin

2015-07-10

In addition to property damage and loss of lives, environment pollution, such as water pollution and air pollution caused by accidents in chemical industrial parks (CIPs) is a significant issue in China. An emergency response system (ERS) was therefore planned to properly and proactively cope with safety incidents including fire and explosions occurring in the CIPs in this study. Using a scenario analysis, the stages of emergency response were divided into three levels, after introducing the domino effect, and fundamental requirements of ERS design were confirmed. The framework of ERS was composed mainly of a monitoring system, an emergency command center, an action system, and a supporting system. On this basis, six main emergency rescue steps containing alarm receipt, emergency evaluation, launched corresponding emergency plans, emergency rescue actions, emergency recovery, and result evaluation and feedback were determined. Finally, an example from the XiaoHu Chemical Industrial Park (XHCIP) was presented to check on the integrality, reliability, and maneuverability of the ERS, and the result of the first emergency drill with this ERS indicated that the developed ERS can reduce delays, improve usage efficiency of resources, and raise emergency rescue efficiency.

Physiologically constrained aerocapture for manned Mars missions

NASA Technical Reports Server (NTRS)

Lyne, James Evans

1992-01-01

Aerobraking has been proposed as a critical technology for manned missions to Mars. The variety of mission architectures currently under consideration presents aerobrake designers with an enormous range of potential entry scenarios. Two of the most important considerations in the design of an aerobrake are the required control authority (lift-to-drag ratio) and the aerothermal environment which the vehicle will encounter. Therefore, this study examined the entry corridor width and stagnation-point heating rate and load for the entire range of probable entry velocities, lift-to-drag ratios, and ballistic coefficients for capture at both Earth and Mars. To accomplish this, a peak deceleration limit for the aerocapture maneuvers had to be established. Previous studies had used a variety of load limits without adequate proof of their validity. Existing physiological and space flight data were examined, and it was concluded that a deceleration limit of 5 G was appropriate. When this load limit was applied, numerical studies showed that an aerobrake with an L/D of 0.3 could provide an entry corridor width of at least 1 degree for all Mars aerocaptures considered with entry velocities up to 9 km/s. If 10 km/s entries are required, an L/D of 0.4 to 0.5 would be necessary to maintain a corridor width of at least 1 degree. For Earth return aerocapture, a vehicle with an L/D of 0.4 to 0.5 was found to provide a corridor width of 0.7 degree or more for all entry velocities up to 14.5 km/s. Aerodynamic convective heating calculations were performed assuming a fully catalytic, 'cold' wall; radiative heating was calculated assuming that the shock layer was in thermochemical equilibrium. Heating rates were low enough for selected entries at Mars that a radiatively cooled thermal protection system might be feasible, although an ablative material would be required for most scenarios. Earth return heating rates were generally more severe than those encountered by the Apollo vehicles

Modeling Complex Chemical Systems: Problems and Solutions

NASA Astrophysics Data System (ADS)

van Dijk, Jan

2016-09-01

Non-equilibrium plasmas in complex gas mixtures are at the heart of numerous contemporary technologies. They typically contain dozens to hundreds of species, involved in hundreds to thousands of reactions. Chemists and physicists have always been interested in what are now called chemical reduction techniques (CRT's). The idea of such CRT's is that they reduce the number of species that need to be considered explicitly without compromising the validity of the model. This is usually achieved on the basis of an analysis of the reaction time scales of the system under study, which identifies species that are in partial equilibrium after a given time span. The first such CRT that has been widely used in plasma physics was developed in the 1960's and resulted in the concept of effective ionization and recombination rates. It was later generalized to systems in which multiple levels are effected by transport. In recent years there has been a renewed interest in tools for chemical reduction and reaction pathway analysis. An example of the latter is the PumpKin tool. Another trend is that techniques that have previously been developed in other fields of science are adapted as to be able to handle the plasma state of matter. Examples are the Intrinsic Low Dimension Manifold (ILDM) method and its derivatives, which originate from combustion engineering, and the general-purpose Principle Component Analysis (PCA) technique. In this contribution we will provide an overview of the most common reduction techniques, then critically assess the pros and cons of the methods that have gained most popularity in recent years. Examples will be provided for plasmas in argon and carbon dioxide.

Design and development of a space station hazardous material system for assessing chemical compatibility

NASA Technical Reports Server (NTRS)

Congo, Richard T.

1990-01-01

As the Space Station nears reality in funding support from Congress, NASA plans to perform over a hundred different missions in the coming decade. Incrementally deployed, the Space Station will evolve into modules linked to an integral structure. Each module will have characteristic functions, such as logistics, habitation, and materials processing. Because the Space Station is to be user friendly for experimenters, NASA is anticipating that a variety of different chemicals will be taken on-board. Accidental release of these potentially toxic chemicals and their chemical compatibility is the focus of this discourse. The Microgravity Manufacturing Processing Facility (MMPF) will contain the various facilities within the U.S. Laboratory (USL). Each facility will have a characteristic purpose, such as alloy solidification or vapor crystal growth. By examining the proposed experiments for each facility, identifying the chemical constituents, their physical state and/or changes, byproducts and effluents, those payloads can be identified which may contain toxic, explosive, or reactive compounds that require processing or containment in mission peculiar waste management systems. Synergistic reactions from mixed effluent streams is of major concern. Each experiment will have it own data file, complete with schematic, chemical listing, physical data, etc. Chemical compatibility information from various databases will provide assistance in the analysis of alternate disposal techniques (pretreatment, separate storage, etc.). Along with data from the Risk Analysis of the Proposed USL Waste Management System, accidental release of potentially toxic and catastrophic chemicals would be eliminated or reduced.

System, device, and methods for real-time screening of live cells, biomarkers, and chemical signatures

DOEpatents

Sundaram, S Kamakshi [Richland, WA; Riley, Brian J [West Richland, WA; Weber, Thomas J [Richland, WA; Sacksteder, Colette A [West Richland, WA; Addleman, R Shane [Benton City, WA

2011-06-07

An ATR-FTIR device and system are described that defect live-cell responses to stimuli and perturbations in real-time. The system and device can monitor perturbations resulting from exposures to various physical, chemical, and biological materials in real-time, as well as those sustained over a long period of time, including those associated with stimuli having unknown modes-of-action (e.g. nanoparticles). The device and system can also be used to identify specific chemical species or substances that profile cellular responses to these perturbations.

Upper Limits for Power Yield in Thermal, Chemical, and Electrochemical Systems

NASA Astrophysics Data System (ADS)

Sieniutycz, Stanislaw

2010-03-01

We consider modeling and power optimization of energy converters, such as thermal, solar and chemical engines and fuel cells. Thermodynamic principles lead to expressions for converter's efficiency and generated power. Efficiency equations serve to solve the problems of upgrading or downgrading a resource. Power yield is a cumulative effect in a system consisting of a resource, engines, and an infinite bath. While optimization of steady state systems requires using the differential calculus and Lagrange multipliers, dynamic optimization involves variational calculus and dynamic programming. The primary result of static optimization is the upper limit of power, whereas that of dynamic optimization is a finite-rate counterpart of classical reversible work (exergy). The latter quantity depends on the end state coordinates and a dissipation index, h, which is the Hamiltonian of the problem of minimum entropy production. In reacting systems, an active part of chemical affinity constitutes a major component of the overall efficiency. The theory is also applied to fuel cells regarded as electrochemical flow engines. Enhanced bounds on power yield follow, which are stronger than those predicted by the reversible work potential.

Porous TiO2-Based Gas Sensors for Cyber Chemical Systems to Provide Security and Medical Diagnosis

PubMed Central

2017-01-01

Gas sensors play an important role in our life, providing control and security of technical processes, environment, transportation and healthcare. Consequently, the development of high performance gas sensor devices is the subject of intense research. TiO2, with its excellent physical and chemical properties, is a very attractive material for the fabrication of chemical sensors. Meanwhile, the emerging technologies are focused on the fabrication of more flexible and smart systems for precise monitoring and diagnosis in real-time. The proposed cyber chemical systems in this paper are based on the integration of cyber elements with the chemical sensor devices. These systems may have a crucial effect on the environmental and industrial safety, control of carriage of dangerous goods and medicine. This review highlights the recent developments on fabrication of porous TiO2-based chemical gas sensors for their application in cyber chemical system showing the convenience and feasibility of such a model to provide the security and to perform the diagnostics. The most of reports have demonstrated that the fabrication of doped, mixed and composite structures based on porous TiO2 may drastically improve its sensing performance. In addition, each component has its unique effect on the sensing properties of material. PMID:29257076

Research on the chemical mechanism in the polyacrylate latex modified cement system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Min; Wang, Rumin, E-mail: wangmin19@mail.nwpu.edu.cn; Zheng, Shuirong

2015-10-15

In this paper, the chemical mechanism in the polyacrylate latex modified cement system was investigated by Fourier transform infrared spectra (FT-IR), X-ray photoelectron spectroscopy (XPS), gel permeation chromatography (GPC) and compact pH meter. All results have shown that the chemical reactions in the polyacrylate modified system can be divided into three stages. The hydration reactions of cement can produce large amounts of Ca(OH){sub 2} (calcium hydroxide) and lead the whole system to be alkali-rich and exothermic at the first stage. Subsequently, this environment can do great contributions to the hydrolysis of ester groups in the polyacrylate chains, resulting in themore » formation of carboxyl groups at the second stage. At the third stage, the final crosslinked network structure of the product was obtained by the reaction between the carboxyl groups in the polyacrylate latex chains and Ca(OH){sub 2}.« less

Fracture Reactivation in Chemically Reactive Rock Systems

NASA Astrophysics Data System (ADS)

Eichhubl, P.; Hooker, J. N.

2013-12-01

Reactivation of existing fractures is a fundamental process of brittle failure that controls the nucleation of earthquake ruptures, propagation and linkage of hydraulic fractures in oil and gas production, and the evolution of fault and fracture networks and thus of fluid and heat transport in the upper crust. At depths below 2-3 km, and frequently shallower, brittle processes of fracture growth, linkage, and reactivation compete with chemical processes of fracture sealing by mineral precipitation, with precipitation rates similar to fracture opening rates. We recently found rates of fracture opening in tectonically quiescent settings of 10-20 μm/m.y., rates similar to euhedral quartz precipitation under these conditions. The tendency of existing partially or completely cemented fractures to reactivate will vary depending on strain rate, mineral precipitation kinetics, strength contrast between host rock and fracture cement, stress conditions, degree of fracture infill, and fracture network geometry. Natural fractures in quartzite of the Cambrian Eriboll Formation, NW Scotland, exhibit a complex history of fracture formation and reactivation, with reactivation involving both repeated crack-seal opening-mode failure and shear failure of fractures that formed in opening mode. Fractures are partially to completely sealed with crack-seal or euhedral quartz cement or quartz cement fragmented by shear reactivation. Degree of cementation controls the tendency of fractures for later shear reactivation, to interact elastically with adjacent open fractures, and their intersection behavior. Using kinematic, dynamic, and diagenetic criteria, we determine the sequence of opening-mode fracture formation and later shear reactivation. We find that sheared fracture systems of similar orientation display spatially varying sense of slip We attribute these inconsistent directions of shear reactivation to 1) a heterogeneous stress field in this highly fractured rock unit and 2

Assessing the chemical contamination dynamics in a mixed land use stream system.

PubMed

Sonne, Anne Th; McKnight, Ursula S; Rønde, Vinni; Bjerg, Poul L

2017-11-15

Traditionally, the monitoring of streams for chemical and ecological status has been limited to surface water concentrations, where the dominant focus has been on general water quality and the risk for eutrophication. Mixed land use stream systems, comprising urban areas and agricultural production, are challenging to assess with multiple chemical stressors impacting stream corridors. New approaches are urgently needed for identifying relevant sources, pathways and potential impacts for implementation of suitable source management and remedial measures. We developed a method for risk assessing chemical stressors in these systems and applied the approach to a 16-km groundwater-fed stream corridor (Grindsted, Denmark). Three methods were combined: (i) in-stream contaminant mass discharge for source quantification, (ii) Toxic Units and (iii) environmental standards. An evaluation of the chemical quality of all three stream compartments - stream water, hyporheic zone, streambed sediment - made it possible to link chemical stressors to their respective sources and obtain new knowledge about source composition and origin. Moreover, toxic unit estimation and comparison to environmental standards revealed the stream water quality was substantially impaired by both geogenic and diffuse anthropogenic sources of metals along the entire corridor, while the streambed was less impacted. Quantification of the contaminant mass discharge originating from a former pharmaceutical factory revealed that several 100 kgs of chlorinated ethenes and pharmaceutical compounds discharge into the stream every year. The strongly reduced redox conditions in the plume result in high concentrations of dissolved iron and additionally release arsenic, generating the complex contaminant mixture found in the narrow discharge zone. The fingerprint of the plume was observed in the stream several km downgradient, while nutrients, inorganics and pesticides played a minor role for the stream health. The

Predicting In Vivo Effect Levels for Repeat Dose Systemic Toxicity using Chemical, Biological, Kinetic and Study Covariates

EPA Science Inventory

In an effort to ensure chemical safety while reducing reliance on animal testing, USEPA and L’Oréal have collaborated to address a major challenge in chemical safety assessment using alternative approaches: the prediction of points-of-departure (POD) of systemic effects. Systemic...

Silica Retention and Enrichment in Open-System Chemical Weathering on Mars

NASA Technical Reports Server (NTRS)

Yen, A. S.; Ming, D. W.; Gellert, R.; Clark, B. C.; Mittlefehldt, D. W.; Morris, R. V.; Thompson, L. M.; Berger, J.

2015-01-01

Chemical signatures of weathering are evident in the Alpha Particle X-ray Spectrometer (APXS) datasets from Gusev Crater, Meridiani Planum, and Gale Crater. Comparisons across the landing sites show consistent patterns indicating silica retention and/or enrichment in open-system aqueous alteration.

A New Data Management System for Biological and Chemical Oceanography

NASA Astrophysics Data System (ADS)

Groman, R. C.; Chandler, C.; Allison, D.; Glover, D. M.; Wiebe, P. H.

2007-12-01

The Biological and Chemical Oceanography Data Management Office (BCO-DMO) was created to serve PIs principally funded by NSF to conduct marine chemical and ecological research. The new office is dedicated to providing open access to data and information developed in the course of scientific research on short and intermediate time-frames. The data management system developed in support of U.S. JGOFS and U.S. GLOBEC programs is being modified to support the larger scope of the BCO-DMO effort, which includes ultimately providing a way to exchange data with other data systems. The open access system is based on a philosophy of data stewardship, support for existing and evolving data standards, and use of public domain software. The DMO staff work closely with originating PIs to manage data gathered as part of their individual programs. In the new BCO-DMO data system, project and data set metadata records designed to support re-use of the data are stored in a relational database (MySQL) and the data are stored in or made accessible by the JGOFS/GLOBEC object- oriented, relational, data management system. Data access will be provided via any standard Web browser client user interface through a GIS application (Open Source, OGC-compliant MapServer), a directory listing from the data holdings catalog, or a custom search engine that facilitates data discovery. In an effort to maximize data system interoperability, data will also be available via Web Services; and data set descriptions will be generated to comply with a variety of metadata content standards. The office is located at the Woods Hole Oceanographic Institution and web access is via http://www.bco-dmo.org.

Predicting in vivo effect levels for repeat-dose systemic toxicity using chemical, biological, kinetic and study covariates.

PubMed

Truong, Lisa; Ouedraogo, Gladys; Pham, LyLy; Clouzeau, Jacques; Loisel-Joubert, Sophie; Blanchet, Delphine; Noçairi, Hicham; Setzer, Woodrow; Judson, Richard; Grulke, Chris; Mansouri, Kamel; Martin, Matthew

2018-02-01

In an effort to address a major challenge in chemical safety assessment, alternative approaches for characterizing systemic effect levels, a predictive model was developed. Systemic effect levels were curated from ToxRefDB, HESS-DB and COSMOS-DB from numerous study types totaling 4379 in vivo studies for 1247 chemicals. Observed systemic effects in mammalian models are a complex function of chemical dynamics, kinetics, and inter- and intra-individual variability. To address this complex problem, systemic effect levels were modeled at the study-level by leveraging study covariates (e.g., study type, strain, administration route) in addition to multiple descriptor sets, including chemical (ToxPrint, PaDEL, and Physchem), biological (ToxCast), and kinetic descriptors. Using random forest modeling with cross-validation and external validation procedures, study-level covariates alone accounted for approximately 15% of the variance reducing the root mean squared error (RMSE) from 0.96 log 10 to 0.85 log 10  mg/kg/day, providing a baseline performance metric (lower expectation of model performance). A consensus model developed using a combination of study-level covariates, chemical, biological, and kinetic descriptors explained a total of 43% of the variance with an RMSE of 0.69 log 10  mg/kg/day. A benchmark model (upper expectation of model performance) was also developed with an RMSE of 0.5 log 10  mg/kg/day by incorporating study-level covariates and the mean effect level per chemical. To achieve a representative chemical-level prediction, the minimum study-level predicted and observed effect level per chemical were compared reducing the RMSE from 1.0 to 0.73 log 10  mg/kg/day, equivalent to 87% of predictions falling within an order-of-magnitude of the observed value. Although biological descriptors did not improve model performance, the final model was enriched for biological descriptors that indicated xenobiotic metabolism gene expression, oxidative stress, and

Capacitive chemical sensor

DOEpatents

Manginell, Ronald P; Moorman, Matthew W; Wheeler, David R

2014-05-27

A microfabricated capacitive chemical sensor can be used as an autonomous chemical sensor or as an analyte-sensitive chemical preconcentrator in a larger microanalytical system. The capacitive chemical sensor detects changes in sensing film dielectric properties, such as the dielectric constant, conductivity, or dimensionality. These changes result from the interaction of a target analyte with the sensing film. This capability provides a low-power, self-heating chemical sensor suitable for remote and unattended sensing applications. The capacitive chemical sensor also enables a smart, analyte-sensitive chemical preconcentrator. After sorption of the sample by the sensing film, the film can be rapidly heated to release the sample for further analysis. Therefore, the capacitive chemical sensor can optimize the sample collection time prior to release to enable the rapid and accurate analysis of analytes by a microanalytical system.

pH measurements of FET-based (bio)chemical sensors using portable measurement system.

PubMed

Voitsekhivska, T; Zorgiebel, F; Suthau, E; Wolter, K-J; Bock, K; Cuniberti, G

2015-01-01

In this study we demonstrate the sensing capabilities of a portable multiplex measurement system for FET-based (bio)chemical sensors with an integrated microfluidic interface. We therefore conducted pH measurements with Silicon Nanoribbon FET-based Sensors using different measurement procedures that are suitable for various applications. We have shown multiplexed measurements in aqueous medium for three different modes that are mutually specialized in fast data acquisition (constant drain current), calibration-less sensing (constant gate voltage) and in providing full information content (sweeping mode). Our system therefore allows surface charge sensing for a wide range of applications and is easily adaptable for multiplexed sensing with novel FET-based (bio)chemical sensors.

Chemical potential in active systems: predicting phase equilibrium from bulk equations of state?

NASA Astrophysics Data System (ADS)

Paliwal, Siddharth; Rodenburg, Jeroen; van Roij, René; Dijkstra, Marjolein

2018-01-01

We derive a microscopic expression for a quantity μ that plays the role of chemical potential of active Brownian particles (ABPs) in a steady state in the absence of vortices. We show that μ consists of (i) an intrinsic chemical potential similar to passive systems, which depends on density and self-propulsion speed, but not on the external potential, (ii) the external potential, and (iii) a newly derived one-body swim potential due to the activity of the particles. Our simulations on ABPs show good agreement with our Fokker-Planck calculations, and confirm that μ (z) is spatially constant for several inhomogeneous active fluids in their steady states in a planar geometry. Finally, we show that phase coexistence of ABPs with a planar interface satisfies not only mechanical but also diffusive equilibrium. The coexistence can be well-described by equating the bulk chemical potential and bulk pressure obtained from bulk simulations for systems with low activity but requires explicit evaluation of the interfacial contributions at high activity.

ScreenCube: A 3D Printed System for Rapid and Cost-Effective Chemical Screening in Adult Zebrafish.

PubMed

Monstad-Rios, Adrian T; Watson, Claire J; Kwon, Ronald Y

2018-02-01

Phenotype-based small molecule screens in zebrafish embryos and larvae have been successful in accelerating pathway and therapeutic discovery for diverse biological processes. Yet, the application of chemical screens to adult physiologies has been relatively limited due to additional demands on cost, space, and labor associated with screens in adult animals. In this study, we present a 3D printed system and methods for intermittent drug dosing that enable rapid and cost-effective chemical administration in adult zebrafish. Using prefilled screening plates, the system enables dosing of 96 fish in ∼3 min, with a 10-fold reduction in drug quantity compared to that used in previous chemical screens in adult zebrafish. We characterize water quality kinetics during immersion in the system and use these kinetics to rationally design intermittent dosing regimens that result in 100% fish survival. As a demonstration of system fidelity, we show the potential to identify two known chemical inhibitors of adult tail fin regeneration, cyclopamine and dorsomorphin. By developing methods for rapid and cost-effective chemical administration in adult zebrafish, this study expands the potential for small molecule discovery in postembryonic models of development, disease, and regeneration.

Accurate hybrid stochastic simulation of a system of coupled chemical or biochemical reactions.

PubMed

Salis, Howard; Kaznessis, Yiannis

2005-02-01

The dynamical solution of a well-mixed, nonlinear stochastic chemical kinetic system, described by the Master equation, may be exactly computed using the stochastic simulation algorithm. However, because the computational cost scales with the number of reaction occurrences, systems with one or more "fast" reactions become costly to simulate. This paper describes a hybrid stochastic method that partitions the system into subsets of fast and slow reactions, approximates the fast reactions as a continuous Markov process, using a chemical Langevin equation, and accurately describes the slow dynamics using the integral form of the "Next Reaction" variant of the stochastic simulation algorithm. The key innovation of this method is its mechanism of efficiently monitoring the occurrences of slow, discrete events while simultaneously simulating the dynamics of a continuous, stochastic or deterministic process. In addition, by introducing an approximation in which multiple slow reactions may occur within a time step of the numerical integration of the chemical Langevin equation, the hybrid stochastic method performs much faster with only a marginal decrease in accuracy. Multiple examples, including a biological pulse generator and a large-scale system benchmark, are simulated using the exact and proposed hybrid methods as well as, for comparison, a previous hybrid stochastic method. Probability distributions of the solutions are compared and the weak errors of the first two moments are computed. In general, these hybrid methods may be applied to the simulation of the dynamics of a system described by stochastic differential, ordinary differential, and Master equations.

Mars entry-to-landing trajectory optimization and closed loop guidance

NASA Technical Reports Server (NTRS)

Ilgen, Marc R.; Manning, Raymund A.; Cruz, Manuel I.

1991-01-01

The guidance strategy of the Mars Rover Sample Return mission is presented in detail. Aeromaneuver versus aerobrake trades are examined, and an aerobrake analysis is presented which takes into account targeting, guidance, flight control, trajectory profile, delivery accuracy. An aeromaneuver analysis is given which includes the entry corridor, maneuver footprint, guidance, preentry phase, constant drag phase, equilibrium guide phase, variable drag phase, influence of trajectory profile on the entry flight loads, parachute deployment conditions and strategies, and landing accuracy. The Mars terminal descent phase is analyzed.

PHYSIO-CHEMICAL CHARACTERIZATION OF IRON TUBERCULATION FROM A SINGLE DRINKING WATER DISTRIBUTION SYSTEM

EPA Science Inventory

Corrosion of iron pipes in Drinking Water Distribution Systems (DWDS) contributes to the formation of tubercles whose physio-chemical properties are influenced by the composition of the waters in the distribution system. Thus the objective of this study was to assess the extent o...

A Soil-free System for Assaying Nematicidal Activity of Chemicals

PubMed Central

Preiser, F. A.; Babu, J. R.; Haidri, A. A.

1981-01-01

A biological assay system for studying the nematicidal activity of chemicals has been devised using a model consisting of cucumber (Cucumis sativus L. cv. Long Marketer) seedlings growing in the diSPo® growth-pouch apparatus. Meloidogyne incognita was used as the test organism. The response was quantified in terms of the numbers of galls produced. Statistical procedures were applied to estimate the ED50 values of currently available nematicides. This system permits accurate quantification of galling and requires much less space and effort than the currently used methods. PMID:19300800

A Soil-free System for Assaying Nematicidal Activity of Chemicals.

PubMed

Preiser, F A; Babu, J R; Haidri, A A

1981-10-01

A biological assay system for studying the nematicidal activity of chemicals has been devised using a model consisting of cucumber (Cucumis sativus L. cv. Long Marketer) seedlings growing in the diSPo(R) growth-pouch apparatus. Meloidogyne incognita was used as the test organism. The response was quantified in terms of the numbers of galls produced. Statistical procedures were applied to estimate the ED(50) values of currently available nematicides. This system permits accurate quantification of galling and requires much less space and effort than the currently used methods.

Chemical treatment costs reduced with in-pond receway systems comopared to traditional pond aquaculture

USDA-ARS?s Scientific Manuscript database

Production systems such as in-pond raceway systems (IPRS) and split ponds are providing an alternative to traditional pond culture for raising catfish in several southeastern states. One advantage noted by farmers utilizing these systems is the reduced cost associated with the chemical treatment of...

Chemically evolving systems for oil recovery enhancement in heavy oil deposits

NASA Astrophysics Data System (ADS)

Altunina, L. K.; Kuvshinov, I. V.; Kuvshinov, V. A.; Stasyeva, L. A.

2017-12-01

This work presents the results of laboratory studies and field tests of new physicochemical technologies for enhanced oil recovery of heavy oil fields under natural development conditions and with thermal-steam stimulation using oil-displacing "smart" systems. The systems are based on surfactants and buffer systems. Their rheological and acid-base properties can be regulated by their chemical evolution directly in the formation. Field tests of the technologies carried out on high-viscosity oil deposit in the Usinskoye oilfield have shown that the EOR technologies are environmentally friendly and technologically effective.

Unnatural selection in chemical systems

NASA Technical Reports Server (NTRS)

Orgel, Leslie E.

1995-01-01

The theory of evolution through natural selection was proposed by Darwin and Wallace to explain how the characteristics of populations of animals change with time. An examination of their assumptions shows that the theory has much broader application than they originally envisaged. We now know that in appropriate environments RNA molecules or computer viruses, for example, can evolve. The adventure with which we are concerned is the quest for chemical systems that undergo processes analogous to Darwinian selection in the test tube. The search is not restricted to systems that are closely related to nucleic acids, although most of the available experimental evidence concerns such systems. A population of molecules satisfies all the requirements of the theory is there are different kinds of molecules in the population and if each individual molecule can direct the formation of copies of itself, then a population of molecules will adapt to a varying environment by changing its composition so as to maintain as high as possible a rate of replication. Sol Spiegelman is the inventor of 'unnatural selection'. He showed clearly that populations of RNA molecules evolve when replicated repeatedly by Q beta RNA polymerase under a chosen set of adverse reaction conditions. In the systems that he studied, the initial population was fairly homogeneous and much of the variation was created during the course of the experiment by mutation, that is, error of replication. The term 'unnatural selection' will be used loosely to describe evolution of nucleic acids or other replicatable polymers in vitro. The term 'Natural Selection' will be reserved for the evolution of living organisms and their viruses. Natural Section usually involves the coevolution of nucleic acids and proteins, while 'unnatural selection', as practiced so far, allows replicating nucleic acids to evolve but hold constant the enzymes that catalyze replication. It is widely believed that biology based on DNA, RNA, and

Effect of chemical and mechanical weed control on cassava yield, soil quality and erosion under cassava cropping system

NASA Astrophysics Data System (ADS)

Islami, Titiek; Wisnubroto, Erwin; Utomo, Wani

2016-04-01

Three years field experiments were conducted to study the effect of chemical and mechanical weed control on soil quality and erosion under cassava cropping system. The experiment were conducted at University Brawijaya field experimental station, Jatikerto, Malang, Indonesia. The experiments were carried out from 2011 - 2014. The treatments consist of three cropping system (cassava mono culture; cassava + maize intercropping and cassava + peanut intercropping), and two weed control method (chemical and mechanical methods). The experimental result showed that the yield of cassava first year and second year did not influenced by weed control method and cropping system. However, the third year yield of cassava was influence by weed control method and cropping system. The cassava yield planted in cassava + maize intercropping system with chemical weed control methods was only 24 t/ha, which lower compared to other treatments, even with that of the same cropping system used mechanical weed control. The highest cassava yield in third year was obtained by cassava + peanuts cropping system with mechanical weed control method. After three years experiment, the soil of cassava monoculture system with chemical weed control method possessed the lowest soil organic matter, and soil aggregate stability. During three years of cropping soil erosion in chemical weed control method, especially on cassava monoculture, was higher compared to mechanical weed control method. The soil loss from chemical control method were 40 t/ha, 44 t/ha and 54 t/ha for the first, second and third year crop. The soil loss from mechanical weed control method for the same years was: 36 t/ha, 36 t/ha and 38 t/ha. Key words: herbicide, intercropping, soil organic matter, aggregate stability.

A versatile transfection assay system to evaluate the biological effects of diverse industrial chemicals.

PubMed

Koizumi, Shinji; Ohno, Shotaro; Otsuka, Fuminori

2012-01-01

Gene expression processes are now recognized as important targets of the toxic effects exerted by industrial chemicals. The transient transfection assay is a powerful tool to evaluate such effects. Thus, we developed a versatile assay system by constructing a basic reporter plasmid in which the regulatory DNA sequence to be studied can easily be substituted. To verify the performance of this system, reporter plasmids carrying any of the three distinct regulatory sequences, estrogen responsive element (ERE), glucocorticoid responsive element (GRE) and xenobiotic responsive element (XRE) were constructed. After transfection of human cells, these plasmids successfully expressed the relevant reporter genes in response to specific inducers, β-estradiol, dexamethasone and 3-methylcholanthrene, respectively. Several industrial chemicals were assayed using these reporter plasmids, and the ability of p-dimethylaminoazobenzene to elevate GRE- and XRE-mediated transcription was detected. α-Naphthylamine and o-tolidine were also observed to increase the XRE-mediated response. The transfection assay system established here will be useful to evaluate the effects of a wide variety of industrial chemicals.

Chemical Mechanisms and Their Applications in the Goddard Earth Observing System (GEOS) Earth System Model.

PubMed

Nielsen, J Eric; Pawson, Steven; Molod, Andrea; Auer, Benjamin; da Silva, Arlindo M; Douglass, Anne R; Duncan, Bryan; Liang, Qing; Manyin, Michael; Oman, Luke D; Putman, William; Strahan, Susan E; Wargan, Krzysztof

2017-12-01

NASA's Goddard Earth Observing System (GEOS) Earth System Model (ESM) is a modular, general circulation model (GCM), and data assimilation system (DAS) that is used to simulate and study the coupled dynamics, physics, chemistry, and biology of our planet. GEOS is developed by the Global Modeling and Assimilation Office (GMAO) at NASA Goddard Space Flight Center. It generates near-real-time analyzed data products, reanalyses, and weather and seasonal forecasts to support research targeted to understanding interactions among Earth System processes. For chemistry, our efforts are focused on ozone and its influence on the state of the atmosphere and oceans, and on trace gas data assimilation and global forecasting at mesoscale discretization. Several chemistry and aerosol modules are coupled to the GCM, which enables GEOS to address topics pertinent to NASA's Earth Science Mission. This paper describes the atmospheric chemistry components of GEOS and provides an overview of its Earth System Modeling Framework (ESMF)-based software infrastructure, which promotes a rich spectrum of feedbacks that influence circulation and climate, and impact human and ecosystem health. We detail how GEOS allows model users to select chemical mechanisms and emission scenarios at run time, establish the extent to which the aerosol and chemical components communicate, and decide whether either or both influence the radiative transfer calculations. A variety of resolutions facilitates research on spatial and temporal scales relevant to problems ranging from hourly changes in air quality to trace gas trends in a changing climate. Samples of recent GEOS chemistry applications are provided.

Chemical Mechanisms and Their Applications in the Goddard Earth Observing System (GEOS) Earth System Model

PubMed Central

Pawson, Steven; Molod, Andrea; Auer, Benjamin; da Silva, Arlindo M.; Douglass, Anne R.; Duncan, Bryan; Liang, Qing; Manyin, Michael; Oman, Luke D.; Putman, William; Strahan, Susan E.; Wargan, Krzysztof

2017-01-01

Abstract NASA's Goddard Earth Observing System (GEOS) Earth System Model (ESM) is a modular, general circulation model (GCM), and data assimilation system (DAS) that is used to simulate and study the coupled dynamics, physics, chemistry, and biology of our planet. GEOS is developed by the Global Modeling and Assimilation Office (GMAO) at NASA Goddard Space Flight Center. It generates near‐real‐time analyzed data products, reanalyses, and weather and seasonal forecasts to support research targeted to understanding interactions among Earth System processes. For chemistry, our efforts are focused on ozone and its influence on the state of the atmosphere and oceans, and on trace gas data assimilation and global forecasting at mesoscale discretization. Several chemistry and aerosol modules are coupled to the GCM, which enables GEOS to address topics pertinent to NASA's Earth Science Mission. This paper describes the atmospheric chemistry components of GEOS and provides an overview of its Earth System Modeling Framework (ESMF)‐based software infrastructure, which promotes a rich spectrum of feedbacks that influence circulation and climate, and impact human and ecosystem health. We detail how GEOS allows model users to select chemical mechanisms and emission scenarios at run time, establish the extent to which the aerosol and chemical components communicate, and decide whether either or both influence the radiative transfer calculations. A variety of resolutions facilitates research on spatial and temporal scales relevant to problems ranging from hourly changes in air quality to trace gas trends in a changing climate. Samples of recent GEOS chemistry applications are provided. PMID:29497478

Proceedings of the DOE chemical/hydrogen energy contractor review systems

NASA Technical Reports Server (NTRS)

1978-01-01

Chemical/hydrogen energy system contracts were reviewed. The review served as an effective means to (1) give all contracts an insight into the background and objectives of thirty-nine hydrogen-related tasks, (2) show the status of the studies or technical effort, (3) relate any problems that had impeded the progress, and (4) state projected solutions for resolving the identified problems.

Integrated Baseline System (IBS), Version 1. 03. [Chemical Stockpile Emergency Preparedness Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bailey, B.M.; Burford, M.J.; Downing, T.R.

The Integrated Baseline System (IBS), operated by the Federal Emergency Management Agency (FEMA), is a system of computerized tools for emergency planing and analysis. This document is the user guide for the IBS and explains how to operate the IBS system. The fundamental function of the IBS is to provide tools that civilian emergency management personnel can use in developing emergency plans and in supporting emergency management activities to cope with a chemical-releasing event at a military chemical stockpile. Emergency management planners can evaluate concepts and ideas using the IBS system. The results of that experience can then be factoredmore » into refining requirements and plans. This document provides information for the general system user, and is the primary reference for the system features of the IBS. It is designed for persons who are familiar with general emergency management concepts, operations, and vocabulary. Although the IBS manual set covers basic and advanced operations, it is not a complete reference document set. Emergency situation modeling software in the IBS is supported by additional technical documents. Some of the other LBS software is commercial software for which more complete documentation is available. The IBS manuals reference such documentation where necessary. IBS is a dynamic system. Its capabilities are in a state of continuing expansion and enhancement.« less

Polyoxometalate (POM) catalyst systems : chemical principles and reactions with lignin and oxygen

Treesearch

I.A. Weinstock; R.H. Atalla; J.S. Bond; E.M.G. Barbuzzi; V.A. Grigoriev; Y. Gueletii; J.J. Cowan; D.M. Sonnen; R.S. Reiner; S.E. Reichel; R.A. Heintz; C.J. Houtman; A.J. Bailey; C.L. Hill

2000-01-01

Chemical data pertinent to most-recently developed POM delignification systems will be presented. These data will be used to demonstrate the fundamental basis for the stability, self-buffering properties, versatility and high selectivity of these systems when used in combination with oxygen to convert native or residual lignin in wood or wood-pulp fibers to CO2 and H2O...

Human exposure to endocrine disrupting chemicals: effects on the male and female reproductive systems.

PubMed

Sifakis, Stavros; Androutsopoulos, Vasilis P; Tsatsakis, Aristeidis M; Spandidos, Demetrios A

2017-04-01

Endocrine disrupting chemicals (EDCs) comprise a group of chemical compounds that have been examined extensively due to the potential harmful effects in the health of human populations. During the past decades, particular focus has been given to the harmful effects of EDCs to the reproductive system. The estimation of human exposure to EDCs can be broadly categorized into occupational and environmental exposure, and has been a major challenge due to the structural diversity of the chemicals that are derived by many different sources at doses below the limit of detection used by conventional methodologies. Animal and in vitro studies have supported the conclusion that endocrine disrupting chemicals affect the hormone dependent pathways responsible for male and female gonadal development, either through direct interaction with hormone receptors or via epigenetic and cell-cycle regulatory modes of action. In human populations, the majority of the studies point towards an association between exposure to EDCs and male and/or female reproduction system disorders, such as infertility, endometriosis, breast cancer, testicular cancer, poor sperm quality and/or function. Despite promising discoveries, a causal relationship between the reproductive disorders and exposure to specific toxicants is yet to be established, due to the complexity of the clinical protocols used, the degree of occupational or environmental exposure, the determination of the variables measured and the sample size of the subjects examined. Future studies should focus on a uniform system of examining human populations with regard to the exposure to specific EDCs and the direct effect on the reproductive system. Copyright © 2017 Elsevier B.V. All rights reserved.

Systematic chemical-genetic and chemical-chemical interaction datasets for prediction of compound synergism

PubMed Central

Wildenhain, Jan; Spitzer, Michaela; Dolma, Sonam; Jarvik, Nick; White, Rachel; Roy, Marcia; Griffiths, Emma; Bellows, David S.; Wright, Gerard D.; Tyers, Mike

2016-01-01

The network structure of biological systems suggests that effective therapeutic intervention may require combinations of agents that act synergistically. However, a dearth of systematic chemical combination datasets have limited the development of predictive algorithms for chemical synergism. Here, we report two large datasets of linked chemical-genetic and chemical-chemical interactions in the budding yeast Saccharomyces cerevisiae. We screened 5,518 unique compounds against 242 diverse yeast gene deletion strains to generate an extended chemical-genetic matrix (CGM) of 492,126 chemical-gene interaction measurements. This CGM dataset contained 1,434 genotype-specific inhibitors, termed cryptagens. We selected 128 structurally diverse cryptagens and tested all pairwise combinations to generate a benchmark dataset of 8,128 pairwise chemical-chemical interaction tests for synergy prediction, termed the cryptagen matrix (CM). An accompanying database resource called ChemGRID was developed to enable analysis, visualisation and downloads of all data. The CGM and CM datasets will facilitate the benchmarking of computational approaches for synergy prediction, as well as chemical structure-activity relationship models for anti-fungal drug discovery. PMID:27874849

Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems

PubMed Central

Lü, Jian-Ming; Lin, Peter H; Yao, Qizhi; Chen, Changyi

2010-01-01

Abstract Free radicals derived from oxygen, nitrogen and sulphur molecules in the biological system are highly active to react with other molecules due to their unpaired electrons. These radicals are important part of groups of molecules called reactive oxygen/nitrogen species (ROS/RNS), which are produced during cellular metabolism and functional activities and have important roles in cell signalling, apoptosis, gene expression and ion transportation. However, excessive ROS attack bases in nucleic acids, amino acid side chains in proteins and double bonds in unsaturated fatty acids, and cause oxidative stress, which can damage DNA, RNA, proteins and lipids resulting in an increased risk for cardiovascular disease, cancer, autism and other diseases. Intracellular antioxidant enzymes and intake of dietary antioxidants may help to maintain an adequate antioxidant status in the body. In the past decades, new molecular techniques, cell cultures and animal models have been established to study the effects and mechanisms of antioxidants on ROS. The chemical and molecular approaches have been used to study the mechanism and kinetics of antioxidants and to identify new potent antioxidants. Antioxidants can decrease the oxidative damage directly via reacting with free radicals or indirectly by inhibiting the activity or expression of free radical generating enzymes or enhancing the activity or expression of intracellular antioxidant enzymes. The new chemical and cell-free biological system has been applied in dissecting the molecular action of antioxidants. This review focuses on the research approaches that have been used to study oxidative stress and antioxidants in lipid peroxidation, DNA damage, protein modification as well as enzyme activity, with emphasis on the chemical and cell-free biological system. PMID:19754673

Chemical evolutionary games.

PubMed

Aristotelous, Andreas C; Durrett, Richard

2014-05-01

Inspired by the use of hybrid cellular automata in modeling cancer, we introduce a generalization of evolutionary games in which cells produce and absorb chemicals, and the chemical concentrations dictate the death rates of cells and their fitnesses. Our long term aim is to understand how the details of the interactions in a system with n species and m chemicals translate into the qualitative behavior of the system. Here, we study two simple 2×2 games with two chemicals and revisit the two and three species versions of the one chemical colicin system studied earlier by Durrett and Levin (1997). We find that in the 2×2 examples, the behavior of our new spatial model can be predicted from that of the mean field differential equation using ideas of Durrett and Levin (1994). However, in the three species colicin model, the system with diffusion does not have the coexistence which occurs in the lattices model in which sites interact with only their nearest neighbors. Copyright © 2014 Elsevier Inc. All rights reserved.

SRS: Site ranking system for hazardous chemical and radioactive waste

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rechard, R.P.; Chu, M.S.Y.; Brown, S.L.

1988-05-01

This report describes the rationale and presents instructions for a site ranking system (SRS). SRS ranks hazardous chemical and radioactive waste sites by scoring important and readily available factors that influence risk to human health. Using SRS, sites can be ranked for purposes of detailed site investigations. SRS evaluates the relative risk as a combination of potentially exposed population, chemical toxicity, and potential exposure of release from a waste site; hence, SRS uses the same concepts found in a detailed assessment of health risk. Basing SRS on the concepts of risk assessment tends to reduce the distortion of results foundmore » in other ranking schemes. More importantly, a clear logic helps ensure the successful application of the ranking procedure and increases its versatility when modifications are necessary for unique situations. Although one can rank sites using a detailed risk assessment, it is potentially costly because of data and resources required. SRS is an efficient approach to provide an order-of-magnitude ranking, requiring only readily available data (often only descriptive) and hand calculations. Worksheets are included to make the system easier to understand and use. 88 refs., 19 figs., 58 tabs.« less

Geometrical Description of Chemical Equilibrium and Le Cha^telier's Principle: Two-Component Systems

ERIC Educational Resources Information Center

Novak, Igor

2018-01-01

Chemical equilibrium is one of the most important concepts in chemistry. The changes in properties of the chemical system at equilibrium induced by variations in pressure, volume, temperature, and concentration are always included in classroom teaching and discussions. This work introduces a novel, geometrical approach to understanding the…

Chemical environments of submarine hydrothermal systems

NASA Technical Reports Server (NTRS)

Shock, Everett L.

1992-01-01

Perhaps because black-smoker chimneys make tremendous subjects for magazine covers, the proposal that submarine hydrothermal systems were involved in the origin of life has caused many investigators to focus on the eye-catching hydrothermal vents. In much the same way that tourists rush to watch the spectacular eruptions of Old Faithful geyser with little regard for the hydrology of the Yellowstone basin, attention is focused on the spectacular, high-temperature hydrothermal vents to the near exclusion of the enormous underlying hydrothermal systems. Nevertheless, the magnitude and complexity of geologic structures, heat flow, and hydrologic parameters which characterize the geyser basins at Yellowstone also characterize submarine hydrothermal systems. However, in the submarine systems the scale can be considerably more vast. Like Old Faithful, submarine hydrothermal vents have a spectacular quality, but they are only one fascinating aspect of enormous geologic systems operating at seafloor spreading centers throughout all of the ocean basins. A critical study of the possible role of hydrothermal processes in the origin of life should include the full spectrum of probable environments. The goals of this chapter are to synthesize diverse information about the inorganic geochemistry of submarine hydrothermal systems, assemble a description of the fundamental physical and chemical attributes of these systems, and consider the implications of high-temperature, fluid-driven processes for organic synthesis. Information about submarine hydrothermal systems comes from many directions. Measurements made directly on venting fluids provide useful, but remarkably limited, clues about processes operating at depth. The oceanic crust has been drilled to approximately 2.0 km depth providing many other pieces of information, but drilling technology has not allowed the bore holes and core samples to reach the maximum depths to which aqueous fluids circulate in oceanic crust. Such

Definition of large components assembled on-orbit and robot compatible mechanical joints

NASA Technical Reports Server (NTRS)

Williamsen, J.; Thomas, F.; Finckenor, J.; Spiegel, B.

1990-01-01

One of four major areas of project Pathfinder is in-space assembly and construction. The task of in-space assembly and construction is to develop the requirements and the technology needed to build elements in space. A 120-ft diameter tetrahedral aerobrake truss is identified as the focus element. A heavily loaded mechanical joint is designed to robotically assemble the defined aerobrake element. Also, typical large components such as habitation modules, storage tanks, etc., are defined, and attachment concepts of these components to the tetrahedral truss are developed.

Study of electrical and chemical propulsion systems for auxiliary propulsion of large space systems, volume 2

NASA Technical Reports Server (NTRS)

Smith, W. W.

1981-01-01

The five major tasks of the program are reported. Task 1 is a literature search followed by selection and definition of seven generic spacecraft classes. Task 2 covers the determination and description of important disturbance effects. Task 3 applies the disturbances to the generic spacecraft and adds maneuver and stationkeeping functions to define total auxiliary propulsion systems requirements for control. The important auxiliary propulsion system characteristics are identified and sensitivities to control functions and large space system characteristics determined. In Task 4, these sensitivities are quantified and the optimum auxiliary propulsion system characteristics determined. Task 5 compares the desired characteristics with those available for both electrical and chemical auxiliary propulsion systems to identify the directions technology advances should take.

Reachability bounds for chemical reaction networks and strand displacement systems.

PubMed

Condon, Anne; Kirkpatrick, Bonnie; Maňuch, Ján

2014-01-01

Chemical reaction networks (CRNs) and DNA strand displacement systems (DSDs) are widely-studied and useful models of molecular programming. However, in order for some DSDs in the literature to behave in an expected manner, the initial number of copies of some reagents is required to be fixed. In this paper we show that, when multiple copies of all initial molecules are present, general types of CRNs and DSDs fail to work correctly if the length of the shortest sequence of reactions needed to produce any given molecule exceeds a threshold that grows polynomially with attributes of the system.

Primary culture system of adrenocortical cells from dogs to evaluate direct effects of chemicals on steroidogenesis.

PubMed

Morishita, K; Okumura, H; Ito, N; Takahashi, N

2001-08-28

The present study was conducted to confirm the usefulness of a primary culture system of adrenocortical cells from dogs for detecting the direct effects of the chemicals on adrenal cortex. Corticosteroid levels in the culture supernatant were measured using high-performance liquid chromatography (HPLC) following 24-h incubation with the chemicals. Ketoconazole, miconazole, metyrapone, aminoglutethimide, and 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane (o,p-DDD), which were known to inhibit cortisol production were evaluated in this system. Both viable cells and corticosteroid levels were decreased by o,p-DDD treatment. Other chemicals showed various inhibition patterns of corticosteroid levels as follows without affecting cell viability. Ketoconazole decreased total corticosteroids level by mainly due to the decreases in cortisol and 11-deoxycortisol levels. Miconazole decreased cortisol and 11-deoxycortisol levels, however, slightly increased corticosterone level. Metyrapone decreased cortisol and corticosterone levels as 11-deoxycortisol and 11-deoxycorticosterone levels were increased. Aminoglutethimide decreased total corticosteroids level by mainly decreasing cortisol, corticosterone and 11-deoxycortisol levels. These results suggested that determination of the pattern of corticosteroid levels by HPLC in this system well reflected the mode of their action on steroidogenesis. Thus, we conclude this simple system was useful to determine the direct effects of chemicals on steroidogenesis in the adrenal cortex.

Molecular finite-size effects in stochastic models of equilibrium chemical systems.

PubMed

Cianci, Claudia; Smith, Stephen; Grima, Ramon

2016-02-28

The reaction-diffusion master equation (RDME) is a standard modelling approach for understanding stochastic and spatial chemical kinetics. An inherent assumption is that molecules are point-like. Here, we introduce the excluded volume reaction-diffusion master equation (vRDME) which takes into account volume exclusion effects on stochastic kinetics due to a finite molecular radius. We obtain an exact closed form solution of the RDME and of the vRDME for a general chemical system in equilibrium conditions. The difference between the two solutions increases with the ratio of molecular diameter to the compartment length scale. We show that an increase in the fraction of excluded space can (i) lead to deviations from the classical inverse square root law for the noise-strength, (ii) flip the skewness of the probability distribution from right to left-skewed, (iii) shift the equilibrium of bimolecular reactions so that more product molecules are formed, and (iv) strongly modulate the Fano factors and coefficients of variation. These volume exclusion effects are found to be particularly pronounced for chemical species not involved in chemical conservation laws. Finally, we show that statistics obtained using the vRDME are in good agreement with those obtained from Brownian dynamics with excluded volume interactions.

REBURNING THERMAL AND CHEMICAL PROCESSES IN A TWO-DIMENSIONAL PILOT-SCALE SYSTEM

EPA Science Inventory

The paper describes an experimental investigation of the thermal and chemical processes influencing NOx reduction by natural gas reburning in a two-dimensional pilot-scale combustion system. Reburning effectiveness for initial NOx levels of 50-500 ppm and reburn stoichiometric ra...

Chemical Transformation System: Cloud Based Cheminformatic Services to Support Integrated Environmental Modeling

EPA Science Inventory

Integrated Environmental Modeling (IEM) systems that account for the fate/transport of organics frequently require physicochemical properties as well as transformation products. A myriad of chemical property databases exist but these can be difficult to access and often do not co...

Chemical equilibrium. [maximizing entropy of gas system to derive relations between thermodynamic variables

NASA Technical Reports Server (NTRS)

1976-01-01

The entropy of a gas system with the number of particles subject to external control is maximized to derive relations between the thermodynamic variables that obtain at equilibrium. These relations are described in terms of the chemical potential, defined as equivalent partial derivatives of entropy, energy, enthalpy, free energy, or free enthalpy. At equilibrium, the change in total chemical potential must vanish. This fact is used to derive the equilibrium constants for chemical reactions in terms of the partition functions of the species involved in the reaction. Thus the equilibrium constants can be determined accurately, just as other thermodynamic properties, from a knowledge of the energy levels and degeneracies for the gas species involved. These equilibrium constants permit one to calculate the equilibrium concentrations or partial pressures of chemically reacting species that occur in gas mixtures at any given condition of pressure and temperature or volume and temperature.

Remediation System Evaluation, Greenwood Chemical Superfund Site

EPA Pesticide Factsheets

The Greenwood Chemical Site (“site”) is an inactive chemical manufacturing facility located inNewtown, Albemarle County, Virginia on VA Route 690 approximately 0.75 miles west of the town ofGreenwood, Virginia and approximately 20 miles west...

Low-thrust chemical propulsion system propellant expulsion and thermal conditioning study. Executive summary

NASA Technical Reports Server (NTRS)

Merino, F.; Wakabayashi, I.; Pleasant, R. L.; Hill, M.

1982-01-01

Preferred techniques for providing abort pressurization and engine feed system net positive suction pressure (NPSP) for low thrust chemical propulsion systems (LTPS) were determined. A representative LTPS vehicle configuration is presented. Analysis tasks include: propellant heating analysis; pressurant requirements for abort propellant dump; and comparative analysis of pressurization techniques and thermal subcoolers.

Computing Equilibrium Chemical Compositions

NASA Technical Reports Server (NTRS)

Mcbride, Bonnie J.; Gordon, Sanford

1995-01-01

Chemical Equilibrium With Transport Properties, 1993 (CET93) computer program provides data on chemical-equilibrium compositions. Aids calculation of thermodynamic properties of chemical systems. Information essential in design and analysis of such equipment as compressors, turbines, nozzles, engines, shock tubes, heat exchangers, and chemical-processing equipment. CET93/PC is version of CET93 specifically designed to run within 640K memory limit of MS-DOS operating system. CET93/PC written in FORTRAN.

Ground Testing a Nuclear Thermal Rocket: Design of a sub-scale demonstration experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

David Bedsun; Debra Lee; Margaret Townsend

In 2008, the NASA Mars Architecture Team found that the Nuclear Thermal Rocket (NTR) was the preferred propulsion system out of all the combinations of chemical propulsion, solar electric, nuclear electric, aerobrake, and NTR studied. Recently, the National Research Council committee reviewing the NASA Technology Roadmaps recommended the NTR as one of the top 16 technologies that should be pursued by NASA. One of the main issues with developing a NTR for future missions is the ability to economically test the full system on the ground. In the late 1990s, the Sub-surface Active Filtering of Exhaust (SAFE) concept was firstmore » proposed by Howe as a method to test NTRs at full power and full duration. The concept relied on firing the NTR into one of the test holes at the Nevada Test Site which had been constructed to test nuclear weapons. In 2011, the cost of testing a NTR and the cost of performing a proof of concept experiment were evaluated.« less

Chemically-functionalized microcantilevers for detection of chemical, biological and explosive material

DOEpatents

Pinnaduwage, Lal A [Knoxville, TN; Thundat, Thomas G [Knoxville, TN; Brown, Gilbert M [Knoxville, TN; Hawk, John Eric [Olive Branch, MS; Boiadjiev, Vassil I [Knoxville, TN

2007-04-24

A chemically functionalized cantilever system has a cantilever coated on one side thereof with a reagent or biological species which binds to an analyte. The system is of particular value when the analyte is a toxic chemical biological warfare agent or an explosive.

Indoor Air Nuclear, Biological, and Chemical Health Modeling and Assessment System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stenner, Robert D.; Hadley, Donald L.; Armstrong, Peter R.

2001-03-01

Indoor air quality effects on human health are of increasing concern to public health agencies and building owners. The prevention and treatment of 'sick building' syndrome and the spread of air-borne diseases in hospitals, for example, are well known priorities. However, increasing attention is being directed to the vulnerability of our public buildings/places, public security and national defense facilities to terrorist attack or the accidental release of air-borne biological pathogens, harmful chemicals, or radioactive contaminants. The Indoor Air Nuclear, Biological, and Chemical Health Modeling and Assessment System (IA-NBC-HMAS) was developed to serve as a health impact analysis tool for usemore » in addressing these concerns. The overall goal was to develop a user-friendly fully functional prototype Health Modeling and Assessment system, which will operate under the PNNL FRAMES system for ease of use and to maximize its integration with other modeling and assessment capabilities accessible within the FRAMES system (e.g., ambient air fate and transport models, water borne fate and transport models, Physiologically Based Pharmacokinetic models, etc.). The prototype IA-NBC-HMAS is designed to serve as a functional Health Modeling and Assessment system that can be easily tailored to meet specific building analysis needs of a customer. The prototype system was developed and tested using an actual building (i.e., the Churchville Building located at the Aberdeen Proving Ground) and release scenario (i.e., the release and measurement of tracer materials within the building) to ensure realism and practicality in the design and development of the prototype system. A user-friendly "demo" accompanies this report to allow the reader the opportunity for a "hands on" review of the prototype system's capability.« less

Intelligent Chemical Sensor Systems for In-space Safety Applications

NASA Technical Reports Server (NTRS)

Hunter, G. W.; Xu, J. C.; Neudeck, P. G.; Makel, D. B.; Ward, B.; Liu, C. C.

2006-01-01

Future in-space and lunar operations will require significantly improved monitoring and Integrated System Health Management (ISHM) throughout the mission. In particular, the monitoring of chemical species is an important component of an overall monitoring system for space vehicles and operations. For example, in leak monitoring of propulsion systems during launch, inspace, and on lunar surfaces, detection of low concentrations of hydrogen and other fuels is important to avoid explosive conditions that could harm personnel and damage the vehicle. Dependable vehicle operation also depends on the timely and accurate measurement of these leaks. Thus, the development of a sensor array to determine the concentration of fuels such as hydrogen, hydrocarbons, or hydrazine as well as oxygen is necessary. Work has been on-going to develop an integrated smart leak detection system based on miniaturized sensors to detect hydrogen, hydrocarbons, or hydrazine, and oxygen. The approach is to implement Microelectromechanical Systems (MEMS) based sensors incorporated with signal conditioning electronics, power, data storage, and telemetry enabling intelligent systems. The final sensor system will be self-contained with a surface area comparable to a postage stamp. This paper discusses the development of this "Lick and Stick" leak detection system and it s application to In-Space Transportation and other Exploration applications.

Chemical pneumonitis

MedlinePlus

... problems. DO NOT siphon gas, kerosene, or other toxic liquid chemicals. Alternative Names Aspiration pneumonia - chemical Images Lungs Respiratory system References Blanc PD. Acute responses to toxic exposures. In: Broaddus VC, Mason RJ, Ernst JD, ...

Mars Molniya Orbit Atmospheric Resource Mining. [FY 16 NIAC Phase I Project

NASA Technical Reports Server (NTRS)

Mueller, Robert P.; Sforzo, Brandon; Braun, Robert D.; Sibille, Laurent

2017-01-01

This NASA Innovative Advanced Concepts (NIAC) Phase I study examined the revolutionary concept of performing resource collection and utilization during Mars orbital operations in order to enable the landing of large payloads. An exploration architecture was developed, out of which several mission alternatives were developed. Concepts of operations were then developed for each mission alternative, followed by concepts for spacecraft systems, which were traded to assess their feasibility. A novel architecture using Mars Molniya Orbit Atmospheric Resource Mining is feasible to enable an Earth-independent and pioneering, permanent human presence on Mars by providing a reusable, single-stage-to-orbit transportation system. This will allow cargo and crew to be routinely delivered to and from Mars without transporting propellants from Earth.In Phase I, our study explored how electrical energy could be harnessed from the kinetic energy of the incoming spacecraft and then be used to produce the oxygen necessary for landing. This concept of operations is revolutionary in that its focus is on using in situ resources in complementary and varied forms: the upper atmosphere of Mars is used for aerocapture, which is followed by aerobraking, the kinetic energy of the spacecraft is transformed into usable electrical energy during aerobraking, and the atmospheric composition is the source of oxidizer for a landing under supersonic retropropulsion. This NASA Innovative Advanced Concepts (NIAC) Phase I study explores a novel mission architecture to establish routine, Earth-independent transfer of large mass payloads between Earth and the Mars surface and back to Mars orbit. The first stage of routine mission operations involves an atmospheric resource mining aerobraking campaign following aerocapture into a highly elliptical Mars orbit. During each pass through the atmosphere, the vehicle ingests the atmospheric oxidizer and stores it onboard, using solid oxide electrolysis to convert

Chemical effects in ion mixing of a ternary system (metal-SiO2)

NASA Technical Reports Server (NTRS)

Banwell, T.; Nicolet, M.-A.; Sands, T.; Grunthaner, P. J.

1987-01-01

The mixing of Ti, Cr, and Ni thin films with SiO2 by low-temperature (- 196-25 C) irradiation with 290 keV Xe has been investigated. Comparison of the morphology of the intermixed region and the dose dependences of net metal transport into SiO2 reveals that long range motion and phase formation probably occur as separate and sequential processes. Kinetic limitations suppress chemical effects in these systems during the initial transport process. Chemical interactions influence the subsequent phase formation.

EU alerting and reporting systems for potential chemical public health threats and hazards.

PubMed

Orford, R; Crabbe, H; Hague, C; Schaper, A; Duarte-Davidson, R

2014-11-01

A number of European and international IT platforms are used to notify competent authorities of new potential chemical exposures. Recently the European Parliament and the Council of European Union adopted new legislation that aims to improve the co-ordinated response to cross border health threats (Decision 1082/2013/EU). The Decision, inter alia, sets provisions on notification, ad hoc monitoring and coordination of public health measures following serious cross border threats to health from biological, chemical and environmental events as well as events that have an unknown origin. The legal instrument applies to all European Union Member States and is comparable to the International Health Regulations in its content, requirements and adoption of a multiple hazards approach. An inter-sectoral and multidisciplinary response to events with potentially dangerous cross border exposure pathways is often required. For example, European Poisons Centres may be aware of cases of toxic exposure to a product and, in parallel, trading standards may be aware of the same product due to a breach of consumer product standards. Whilst both cases would have been recorded for separate purposes in different alerting systems, they relate to the same exposure pathway; therefore a process for linking these records would allow a more robust approach to risk assessment and risk mitigation. The Decision seeks to reconcile this issue for serious threats by linking relevant platforms into one overarching higher level risk management IT platform called the Early Warning Response System (EWRS). This system will serve to link other sectors within the European Commission (EC) to public health (e.g. medicines), as well as other EU agencies and international bodies via co-notification features. Other European alert systems will be linked to EWRS to facilitate information sharing at both the assessment and management levels. This paper provides a timely overview of the main systems run by the EC

Chemical Equation Balancing.

ERIC Educational Resources Information Center

Blakley, G. R.

1982-01-01

Reviews mathematical techniques for solving systems of homogeneous linear equations and demonstrates that the algebraic method of balancing chemical equations is a matter of solving a system of homogeneous linear equations. FORTRAN programs using this matrix method to chemical equation balancing are available from the author. (JN)

Endocrine-disrupting chemicals-Mechanisms of action on male reproductive system.

PubMed

Sidorkiewicz, Iwona; Zaręba, Kamil; Wołczyński, Sławomir; Czerniecki, Jan

2017-07-01

Endocrine-disrupting chemicals (EDCs) are exogenous compounds that can cause disturbances in the endocrine system and have multiple harmful effects on health by targeting different organs and systems in the human body. Mass industrial production and widespread use of EDCs have resulted in worldwide contamination. Accumulating evidence suggest that human exposure to EDCs is related to the impairment of male reproductive function and can interrupt other hormonally regulated metabolic processes, particularly if exposure occurs during early development. Investigation of studies absent in previous reviews and meta-analysis of adverse effects of EDCs on functioning of the male reproductive system is the core of this work. Four main modes of action of EDCs on male fertility have been summarized in this review. First, studies describing estrogen- pathway disturbing chemicals are investigated. Second, androgen-signaling pathway alterations and influence on androgen sensitive tissues are examined. Third, evaluation of steroidogenesis dysfunction is discussed by focusing on the steroid hormone biosynthesis pathway, which is targeted by EDCs. Last, the reportedly destructive role of reactive oxygen species (ROS) on sperm function is discussed. Spermatogenesis is a remarkably complex process, hence multiple studies point out various dysfunctions depending on the development state at which the exposure occurred. Collected data show the need to account for critical windows of exposure such as fetal, perinatal and pubertal periods as well as effects of mixtures of several compounds in future research.

Mass fluctuation kinetics: Capturing stochastic effects in systems of chemical reactions through coupled mean-variance computations

NASA Astrophysics Data System (ADS)

Gómez-Uribe, Carlos A.; Verghese, George C.

2007-01-01

The intrinsic stochastic effects in chemical reactions, and particularly in biochemical networks, may result in behaviors significantly different from those predicted by deterministic mass action kinetics (MAK). Analyzing stochastic effects, however, is often computationally taxing and complex. The authors describe here the derivation and application of what they term the mass fluctuation kinetics (MFK), a set of deterministic equations to track the means, variances, and covariances of the concentrations of the chemical species in the system. These equations are obtained by approximating the dynamics of the first and second moments of the chemical master equation. Apart from needing knowledge of the system volume, the MFK description requires only the same information used to specify the MAK model, and is not significantly harder to write down or apply. When the effects of fluctuations are negligible, the MFK description typically reduces to MAK. The MFK equations are capable of describing the average behavior of the network substantially better than MAK, because they incorporate the effects of fluctuations on the evolution of the means. They also account for the effects of the means on the evolution of the variances and covariances, to produce quite accurate uncertainty bands around the average behavior. The MFK computations, although approximate, are significantly faster than Monte Carlo methods for computing first and second moments in systems of chemical reactions. They may therefore be used, perhaps along with a few Monte Carlo simulations of sample state trajectories, to efficiently provide a detailed picture of the behavior of a chemical system.

Mars exploration advances: Missions to Mars - Mars base

NASA Technical Reports Server (NTRS)

Dejarnette, Fred R.; Mckay, Christopher P.

1992-01-01

An overview is presented of Mars missions and related planning with attention given to four mission architectures in the light of significant limitations. Planned unpiloted missions are discussed including the Mars Orbital Mapping Mission, the Mars Rover Sample Return, the Mars Aeronomy Orbiter, and the Mars Environmental Survey. General features relevant to the missions are mentioned including launch opportunities, manned-mission phases, and propulsion options. The four mission architectures are set forth and are made up of: (1) the Mars-exploration infrastructures; (2) science emphasis for the moon and Mars; (3) the moon to stay and Mars exploration; and (4) space resource utilization. The possibility of robotic missions to the moon and Mars is touched upon and are concluded to be possible by the end of the century. The ramifications of a Mars base are discussed with specific reference to habitability and base activities, and the human missions are shown to require a heavy-lift launcher and either chemical/aerobrake or nuclear-thermal propulsion system.

BIOAVAILABILITY OF CHEMICAL CONTAMINANTS IN AQUATIC SYSTEMS

EPA Science Inventory

Before a chemical can elicit toxicity, the animal must accumulate a dose at a target tissue of sufficient magnitude to produce a response. Bioavailability refers to the degree to which this accumulation occurs relative to the amount of chemical present in the environment, and is ...

Impact of solar system exploration on theories of chemical evolution and the origin of life

NASA Technical Reports Server (NTRS)

Devincenzi, D. L.

1983-01-01

The impact of solar system exploration on theories regarding chemical evolution and the origin of life is examined in detail. Major findings from missions to Mercury, Venus, the moon, Mars, Jupiter, Saturn, and Titan are reviewed and implications for prebiotic chemistry are discussed. Among the major conclusions are: prebiotic chemistry is widespread throughout the solar system and universe; chemical evolution and the origin of life are intimately associated with the origin and evolution of the solar system; the rate, direction, and extent of prebiotic chemistry is highly dependent upon planetary characteristics; and continued exploration will increase understanding of how life originated on earth and allow better estimates of the likelihood of similar processes occurring elsewhere.

Chemical Looping Combustion Reactions and Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sarofim, Adel; Lighty, JoAnn; Smith, Philip

2014-03-01

. Furthermore, they performed a sensitivity analysis for velocity, height and polydispersity and compared results against literature data for experimental studies of CLC beds with no reaction. Finally, they present an optimization space using simple non-reactive configurations. In Subtask 5.3, through a series of experimental studies, behavior of a variety of oxygen carriers with different loadings and manufacturing techniques was evaluated under both oxidizing and reducing conditions. The influences of temperature, degree of carrier conversion and thermodynamic driving force resulting from the difference between equilibrium and system O{sub 2} partial pressures were evaluated through several experimental campaigns, and generalized models accounting for these influences were developed to describe oxidation and oxygen release. Conversion of three solid fuels with widely ranging reactivities was studied in a small fluidized bed system, and all but the least reactive fuel (petcoke) were rapidly converted by oxygen liberated from the CLOU carrier. Attrition propensity of a variety of carriers was also studied, and the carriers produced by freeze granulation or impregnation of preformed substrates displayed the lowest rates of attrition. Subtask 5.4 focused on gathering kinetic data for a copper-based oxygen carrier to assist with modeling of a functioning chemical looping reactor. The kinetics team was also responsible for the development and analysis of supported copper oxygen carrier material.« less

From chemical neuroanatomy to an understanding of the olfactory system

PubMed Central

Oboti, L.; Peretto, P.; De Marchis, S.; Fasolo, A.

2011-01-01

The olfactory system of mammals is the appropriate model for studying several aspects of neuronal physiology spanning from the developmental stage to neural network remodelling in the adult brain. Both the morphological and physiological understanding of this system were strongly supported by classical histochemistry. It is emblematic the case of the Olfactory Marker Protein (OMP) staining, the first, powerful marker for fully differentiated olfactory receptor neurons and a key tool to investigate the dynamic relations between peripheral sensory epithelia and central relay regions given its presence within olfactory fibers reaching the olfactory bulb (OB). Similarly, the use of thymidine analogues was able to show neurogenesis in an adult mammalian brain far before modern virus labelling and lipophilic tracers based methods. Nowadays, a wealth of new histochemical techniques combining cell and molecular biology approaches is available, giving stance to move from the analysis of the chemically identified circuitries to functional research. The study of adult neurogenesis is indeed one of the best explanatory examples of this statement. After defining the cell types involved and the basic physiology of this phenomenon in the OB plasticity, we can now analyze the role of neurogenesis in well testable behaviours related to socio-chemical communication in rodents. PMID:22297441

Towards Self-Replicating Chemical Systems Based on Cytidylic and Guanylic Acids

NASA Technical Reports Server (NTRS)

Kanavarioti, Anastassia

1999-01-01

This project was aimed towards a better understanding of template-directed reactions and, based on this, towards the development of efficient non-enzymatic RNA replicating systems. These systems could serve as models for the prebiotic synthesis of an RNA world. The major objectives of this project are: (a) To elucidate the mechanistic aspects of template-directed (TD) chemistry and (b) to identify active boundary regions, or conditions, environmental and other, that favor "organized chemistry" and stereo-selective polymerization of nucleotides. "Organized chemistry" may lead to enhanced polymerization efficiency which in turn is expected to facilitate the road towards a self-replicating chemical system based on all four nucleic acid bases.

Biological and chemical terrorism scenarios and implications for detection systems needs

NASA Astrophysics Data System (ADS)

Gordon, Susanna P.; Chumfong, Isabelle; Edwards, Donna M.; Gleason, Nathaniel J.; West, Todd; Yang, Lynn

2007-04-01

Terrorists intent on causing many deaths and severe disruption to our society could, in theory, cause hundreds to tens of thousands of deaths and significant contamination of key urban facilities by using chemical or biological (CB) agents. The attacks that have occurred to date, such as the 1995 Aum Shinrikyo CB attacks and the 2001 anthrax letters, have been very small on the scale of what is possible. In order to defend against and mitigate the impacts of large-scale terrorist attacks, defensive systems for protection of urban areas and high-value facilities from biological and chemical threats have been deployed. This paper reviews analyses of such scenarios and of the efficacy of potential response options, discusses defensive systems that have been deployed and detectors that are being developed, and finally outlines the detection systems that will be needed for improved CB defense in the future. Sandia's collaboration with San Francisco International Airport on CB defense will also be briefly reviewed, including an overview of airport facility defense guidelines produced in collaboration with Lawrence Berkeley National Laboratory. The analyses that will be discussed were conducted by Sandia National Laboratories' Systems Studies Department in support of the U.S. Department of Homeland Security (DHS) Science and Technology Directorate, and include quantitative analyses utilizing simulation models developed through close collaboration with subject matter experts, such as public health officials in urban areas and biological defense experts.

Chemical reaction of hexagonal boron nitride and graphite nanoclusters in mechanical milling systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Muramatsu, Y.; Grush, M.; Callcott, T.A.

1997-04-01

Synthesis of boron-carbon-nitride (BCN) hybrid alloys has been attempted extensively by many researchers because the BCN alloys are considered an extremely hard material called {open_quotes}super diamond,{close_quotes} and the industrial application for wear-resistant materials is promising. A mechanical alloying (MA) method of hexagonal boron nitride (h-BN) with graphite has recently been studied to explore the industrial synthesis of the BCN alloys. To develop the MA method for the BCN alloy synthesis, it is necessary to confirm the chemical reaction processes in the mechanical milling systems and to identify the reaction products. Therefore, the authors have attempted to confirm the chemical reactionmore » process of the h-BN and graphite in mechanical milling systems using x-ray absorption near edge structure (XANES) methods.« less

Integrating Sustainable Development in Chemical Engineering Education: The Application of an Environmental Management System

ERIC Educational Resources Information Center

Montanes, M. T.; Palomares, A. E.; Sanchez-Tovar, R.

2012-01-01

The principles of sustainable development have been integrated in chemical engineering education by means of an environmental management system. These principles have been introduced in the teaching laboratories where students perform their practical classes. In this paper, the implementation of the environmental management system, the problems…

Integrated defense system overlaps as a disease model: with examples for multiple chemical sensitivity.

PubMed Central

Rowat, S C

1998-01-01

The central nervous, immune, and endocrine systems communicate through multiple common messengers. Over evolutionary time, what may be termed integrated defense system(s) (IDS) have developed to coordinate these communications for specific contexts; these include the stress response, acute-phase response, nonspecific immune response, immune response to antigen, kindling, tolerance, time-dependent sensitization, neurogenic switching, and traumatic dissociation (TD). These IDSs are described and their overlap is examined. Three models of disease production are generated: damage, in which IDSs function incorrectly; inadequate/inappropriate, in which IDS response is outstripped by a changing context; and evolving/learning, in which the IDS learned response to a context is deemed pathologic. Mechanisms of multiple chemical sensitivity (MCS) are developed from several IDS disease models. Model 1A is pesticide damage to the central nervous system, overlapping with body chemical burdens, TD, and chronic zinc deficiency; model 1B is benzene disruption of interleukin-1, overlapping with childhood developmental windows and hapten-antigenic spreading; and model 1C is autoimmunity to immunoglobulin-G (IgG), overlapping with spreading to other IgG-inducers, sudden spreading of inciters, and food-contaminating chemicals. Model 2A is chemical and stress overload, including comparison with the susceptibility/sensitization/triggering/spreading model; model 2B is genetic mercury allergy, overlapping with: heavy metals/zinc displacement and childhood/gestational mercury exposures; and model 3 is MCS as evolution and learning. Remarks are offered on current MCS research. Problems with clinical measurement are suggested on the basis of IDS models. Large-sample patient self-report epidemiology is described as an alternative or addition to clinical biomarker and animal testing. Images Figure 1 Figure 2 Figure 3 Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 PMID:9539008

Field programmable chemistry: integrated chemical and electronic processing of informational molecules towards electronic chemical cells.

PubMed

Wagler, Patrick F; Tangen, Uwe; Maeke, Thomas; McCaskill, John S

2012-07-01

The topic addressed is that of combining self-constructing chemical systems with electronic computation to form unconventional embedded computation systems performing complex nano-scale chemical tasks autonomously. The hybrid route to complex programmable chemistry, and ultimately to artificial cells based on novel chemistry, requires a solution of the two-way massively parallel coupling problem between digital electronics and chemical systems. We present a chemical microprocessor technology and show how it can provide a generic programmable platform for complex molecular processing tasks in Field Programmable Chemistry, including steps towards the grand challenge of constructing the first electronic chemical cells. Field programmable chemistry employs a massively parallel field of electrodes, under the control of latched voltages, which are used to modulate chemical activity. We implement such a field programmable chemistry which links to chemistry in rather generic, two-phase microfluidic channel networks that are separated into weakly coupled domains. Electric fields, produced by the high-density array of electrodes embedded in the channel floors, are used to control the transport of chemicals across the hydrodynamic barriers separating domains. In the absence of electric fields, separate microfluidic domains are essentially independent with only slow diffusional interchange of chemicals. Electronic chemical cells, based on chemical microprocessors, exploit a spatially resolved sandwich structure in which the electronic and chemical systems are locally coupled through homogeneous fine-grained actuation and sensor networks and play symmetric and complementary roles. We describe how these systems are fabricated, experimentally test their basic functionality, simulate their potential (e.g. for feed forward digital electrophoretic (FFDE) separation) and outline the application to building electronic chemical cells. Copyright © 2012 Elsevier Ireland Ltd. All rights

Guidelines for Managing Suspected Chemical and Biological Agent Incidents in Rail Tunnel Systems

DOT National Transportation Integrated Search

2002-03-01

These emergency management guidelines are designed to help transit managers (1) prepare and implement standard operating procedures (SOPs) for handling potential and actual chemical or biological agent attacks in their rail tunnel system and (2) unde...

Ephemeral collision complexes mediate chemically termolecular transformations that affect system chemistry [Ephemeral collision complexes induce chemically termolecular transformations that affect global chemistry

DOE PAGES

Burke, Michael P.; Klippenstein, Stephen J.

2017-08-14

Termolecular association reactions involve ephemeral collision complexes—formed from the collision of two molecules—that collide with a third and chemically inert ‘bath gas’ molecule that simply transfers energy to/from the complex. These collision complexes are generally not thought to react chemically on collision with a third molecule in the gas-phase systems of combustion and planetary atmospheres. Such ‘chemically termolecular’ reactions, in which all three molecules are involved in bond making and/or breaking, were hypothesized long ago in studies establishing radical chain branching mechanisms, but were later concluded to be unimportant. Here, with data from ab initio master equation and kinetic-transport simulations,more » we reveal that reactions of H+O 2 collision complexes with other radicals constitute major kinetic pathways under common combustion situations. These reactions are also found to influence flame propagation speeds, a common measure of global reactivity. As a result, analogous chemically termolecular reactions mediated by ephemeral collision complexes are probably of significance in various combustion and planetary environments.« less

Ephemeral collision complexes mediate chemically termolecular transformations that affect system chemistry [Ephemeral collision complexes induce chemically termolecular transformations that affect global chemistry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burke, Michael P.; Klippenstein, Stephen J.

Termolecular association reactions involve ephemeral collision complexes—formed from the collision of two molecules—that collide with a third and chemically inert ‘bath gas’ molecule that simply transfers energy to/from the complex. These collision complexes are generally not thought to react chemically on collision with a third molecule in the gas-phase systems of combustion and planetary atmospheres. Such ‘chemically termolecular’ reactions, in which all three molecules are involved in bond making and/or breaking, were hypothesized long ago in studies establishing radical chain branching mechanisms, but were later concluded to be unimportant. Here, with data from ab initio master equation and kinetic-transport simulations,more » we reveal that reactions of H+O 2 collision complexes with other radicals constitute major kinetic pathways under common combustion situations. These reactions are also found to influence flame propagation speeds, a common measure of global reactivity. As a result, analogous chemically termolecular reactions mediated by ephemeral collision complexes are probably of significance in various combustion and planetary environments.« less

Aerodynamic characteristics of generalized bent biconic bodies for aero-assisted, orbital-transfer vehicles

NASA Technical Reports Server (NTRS)

Davies, C. B.; Park, C.

1983-01-01

A method was developed to generate the surface coordinates of body shapes suitable for aeroassisted, orbital-transfer vehicles (AOTVs) by extending bent biconic geometries. Lift, drag, and longitudinal moments were calculated for the bodies using Newtonian flow theory. These techniques were applied to symmetric and asymmetric aerobraking vehicles, and to an aeromaneuvering vehicle with high L/D. Results for aerobraking applications indicate that a 70 deg, fore half cone angle with a spherically blunted nose, rounded edges, and a slight asymmetry would be appropriate. Moreover, results show that an aeromaneuvering vehicle with L/D 2.0, and with sufficient stability, is feasible.

A transformation theory of stochastic evolution in Red Moon methodology to time evolution of chemical reaction process in the full atomistic system.

PubMed

Suzuki, Yuichi; Nagaoka, Masataka

2017-05-28

Atomistic information of a whole chemical reaction system, e.g., instantaneous microscopic molecular structures and orientations, offers important and deeper insight into clearly understanding unknown chemical phenomena. In accordance with the progress of a number of simultaneous chemical reactions, the Red Moon method (a hybrid Monte Carlo/molecular dynamics reaction method) is capable of simulating atomistically the chemical reaction process from an initial state to the final one of complex chemical reaction systems. In the present study, we have proposed a transformation theory to interpret the chemical reaction process of the Red Moon methodology as the time evolution process in harmony with the chemical kinetics. For the demonstration of the theory, we have chosen the gas reaction system in which the reversible second-order reaction H 2 + I 2  ⇌ 2HI occurs. First, the chemical reaction process was simulated from the initial configurational arrangement containing a number of H 2 and I 2 molecules, each at 300 K, 500 K, and 700 K. To reproduce the chemical equilibrium for the system, the collision frequencies for the reactions were taken into consideration in the theoretical treatment. As a result, the calculated equilibrium concentrations [H 2 ] eq and equilibrium constants K eq at all the temperatures were in good agreement with their corresponding experimental values. Further, we applied the theoretical treatment for the time transformation to the system and have shown that the calculated half-life τ's of [H 2 ] reproduce very well the analytical ones at all the temperatures. It is, therefore, concluded that the application of the present theoretical treatment with the Red Moon method makes it possible to analyze reasonably the time evolution of complex chemical reaction systems to chemical equilibrium at the atomistic level.

Optical methods for creating delivery systems of chemical compounds to plant roots

NASA Astrophysics Data System (ADS)

Kuznetsov, Pavel E.; Rogacheva, Svetlana M.; Arefeva, Oksana A.; Minin, Dmitryi V.; Tolmachev, Sergey A.; Kupadze, Machammad S.

2004-08-01

Spectrophotometric and fluorescence methods have been used for creation and investigation of various systems of target delivery of chemical compounds to roots of plants. The possibility of using liposomes, incrusted by polysaccharides of the external surface of nitrogen-fixing rizospheric bacteria Azospirillum brasilense SP 245, and nanoparticles incrusted by polysaccharides of wheat roots, as the named systems has been shown. The important role of polysaccharide-polysaccharide interaction in the adsorption processes of bacteria on wheat roots has been demonstrated.

Evaluation of the scientific underpinnings for identifying estrogenic chemicals in nonmammalian taxa using mammalian test systems.

PubMed

Ankley, Gerald T; LaLone, Carlie A; Gray, L Earl; Villeneuve, Daniel L; Hornung, Michael W

2016-11-01

The US Environmental Protection Agency has responsibility for assessing endocrine activity of more than 10 000 chemicals, a task that cannot reasonably be achieved solely through use of available mammalian and nonmammalian in vivo screening assays. Hence, it has been proposed that chemicals be prioritized for in vivo testing using data from in vitro high-throughput assays for specific endocrine system targets. Recent efforts focused on potential estrogenic chemicals-specifically those that activate estrogen receptor-alpha (ERα)-have broadly demonstrated feasibility of the approach. However, a major uncertainty is whether prioritization based on mammalian (primarily human) high-throughput assays accurately reflects potential chemical-ERα interactions in nonmammalian species. The authors conducted a comprehensive analysis of cross-species comparability of chemical-ERα interactions based on information concerning structural attributes of estrogen receptors, in vitro binding and transactivation data for ERα, and the effects of a range of chemicals on estrogen-signaling pathways in vivo. Overall, this integrated analysis suggests that chemicals with moderate to high estrogenic potency in mammalian systems also should be priority chemicals in nonmammalian vertebrates. However, the degree to which the prioritization approach might be applicable to invertebrates is uncertain because of a lack of knowledge of the biological role(s) of possible ERα orthologs found in phyla such as annelids. Further, comparative analysis of in vitro data for fish and reptiles suggests that mammalian-based assays may not effectively capture ERα interactions for low-affinity chemicals in all vertebrate classes. Environ Toxicol Chem 2016;35:2806-2816. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and, as such, is in the public domain in the United States of America. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is

IRON TUBERCULATION: PHYSIO-CHEMICAL CHARACTERIZATION OF A SINGLE PIPE FROM A DRINKING WATER DISTRIBUTION SYSTEM

EPA Science Inventory

The nature of iron tubercles inside unlined iron pipes of drinking water distribution systems are influenced by water quality and therefore susceptible to changes in water chemistry. The underlying assumption is that tubercles in a system have similar physio-chemical properties. ...

Assessment of the advantages and feasibility of a nuclear rocket for a manned Mars mission

NASA Technical Reports Server (NTRS)

Howe, Steven D.

1986-01-01

The feasibility of rebuilding and testing a nuclear thermal rocket (NTR) for the Mars mission was investigted. Calculations indicate that an NTR would substantially reduce the Earth-orbit assemble mass compared to LOX/LH2 systems. The mass savings were 36 and 65% for the cases of total aerobraking and of total propulsive braking respectively. Consequently, the cost savings for a single mission of using an NTR, if aerobraking is feasible, are probably insufficient to warrant the NTR development. If multiple missions are planned or if propulsive braking is desired at Mars and/or at Earth, then the savings of about $7 billion will easily pay for the NTR. Estimates of the cost of rebuilding a NTR were based on the previous NERVA program's budget plus additional costs to develop a flight ready engine. The total cost to build the engine would be between $4 to 5 billion. The concept of developing a full-power test stand at Johnston Atoll in the Pacific appears very feasible. The added expense of building facilities on the island should be less than $1.4 billion.

Assessment of the advantages and feasibility of a nuclear rocket for a manned Mars mission

NASA Astrophysics Data System (ADS)

Howe, Steven D.

1986-05-01

The feasibility of rebuilding and testing a nuclear thermal rocket (NTR) for the Mars mission was investigted. Calculations indicate that an NTR would substantially reduce the Earth-orbit assemble mass compared to LOX/LH2 systems. The mass savings were 36 and 65% for the cases of total aerobraking and of total propulsive braking respectively. Consequently, the cost savings for a single mission of using an NTR, if aerobraking is feasible, are probably insufficient to warrant the NTR development. If multiple missions are planned or if propulsive braking is desired at Mars and/or at Earth, then the savings of about $7 billion will easily pay for the NTR. Estimates of the cost of rebuilding a NTR were based on the previous NERVA program's budget plus additional costs to develop a flight ready engine. The total cost to build the engine would be between $4 to 5 billion. The concept of developing a full-power test stand at Johnston Atoll in the Pacific appears very feasible. The added expense of building facilities on the island should be less than $1.4 billion.

Flow Injection Analysis and Liquid Chromatography for Multifunctional Chemical Analysis (MCA) Systems

ERIC Educational Resources Information Center

Mayo, Ana V.; Loegel, Thomas N.; Bretz, Stacey Lowery; Danielson, Neil D.

2013-01-01

The large class sizes of first-year chemistry labs makes it challenging to provide students with hands-on access to instrumentation because the number of students typically far exceeds the number of research-grade instruments available to collect data. Multifunctional chemical analysis (MCA) systems provide a viable alternative for large-scale…

The Global Food System as a Transport Pathway for Hazardous Chemicals: The Missing Link between Emissions and Exposure

PubMed Central

Ng, Carla A.; von Goetz, Natalie

2016-01-01

Background: Food is a major pathway for human exposure to hazardous chemicals. The modern food system is becoming increasingly complex and globalized, but models for food-borne exposure typically assume locally derived diets or use concentrations directly measured in foods without accounting for food origin. Such approaches may not reflect actual chemical intakes because concentrations depend on food origin, and representative analysis is seldom available. Processing, packaging, storage, and transportation also impart different chemicals to food and are not yet adequately addressed. Thus, the link between environmental emissions and realistic human exposure is effectively broken. Objectives: We discuss the need for a fully integrated treatment of the modern industrialized food system, and we propose strategies for using existing models and relevant supporting data sources to track chemicals during production, processing, packaging, storage, and transport. Discussion: Fate and bioaccumulation models describe how chemicals distribute in the environment and accumulate through local food webs. Human exposure models can use concentrations in food to determine body burdens based on individual or population characteristics. New models now include the impacts of processing and packaging but are far from comprehensive. We propose to close the gap between emissions and exposure by utilizing a wider variety of models and data sources, including global food trade data, processing, and packaging models. Conclusions: A comprehensive approach that takes into account the complexity of the modern global food system is essential to enable better prediction of human exposure to chemicals in food, sound risk assessments, and more focused risk abatement strategies. Citation: Ng CA, von Goetz N. 2017. The global food system as a transport pathway for hazardous chemicals: the missing link between emissions and exposure. Environ Health Perspect 125:1–7; http://dx.doi.org/10.1289/EHP

The Global Food System as a Transport Pathway for Hazardous Chemicals: The Missing Link between Emissions and Exposure.

PubMed

Ng, Carla A; von Goetz, Natalie

2017-01-01

Food is a major pathway for human exposure to hazardous chemicals. The modern food system is becoming increasingly complex and globalized, but models for food-borne exposure typically assume locally derived diets or use concentrations directly measured in foods without accounting for food origin. Such approaches may not reflect actual chemical intakes because concentrations depend on food origin, and representative analysis is seldom available. Processing, packaging, storage, and transportation also impart different chemicals to food and are not yet adequately addressed. Thus, the link between environmental emissions and realistic human exposure is effectively broken. We discuss the need for a fully integrated treatment of the modern industrialized food system, and we propose strategies for using existing models and relevant supporting data sources to track chemicals during production, processing, packaging, storage, and transport. Fate and bioaccumulation models describe how chemicals distribute in the environment and accumulate through local food webs. Human exposure models can use concentrations in food to determine body burdens based on individual or population characteristics. New models now include the impacts of processing and packaging but are far from comprehensive. We propose to close the gap between emissions and exposure by utilizing a wider variety of models and data sources, including global food trade data, processing, and packaging models. A comprehensive approach that takes into account the complexity of the modern global food system is essential to enable better prediction of human exposure to chemicals in food, sound risk assessments, and more focused risk abatement strategies. Citation: Ng CA, von Goetz N. 2017. The global food system as a transport pathway for hazardous chemicals: the missing link between emissions and exposure. Environ Health Perspect 125:1-7; http://dx.doi.org/10.1289/EHP168.

Advanced Chemical Propulsion

NASA Technical Reports Server (NTRS)

Alexander, Leslie, Jr.

2006-01-01

Advanced Chemical Propulsion (ACP) provides near-term incremental improvements in propulsion system performance and/or cost. It is an evolutionary approach to technology development that produces useful products along the way to meet increasingly more demanding mission requirements while focusing on improving payload mass fraction to yield greater science capability. Current activities are focused on two areas: chemical propulsion component, subsystem, and manufacturing technologies that offer measurable system level benefits; and the evaluation of high-energy storable propellants with enhanced performance for in-space application. To prioritize candidate propulsion technology alternatives, a variety of propulsion/mission analyses and trades have been conducted for SMD missions to yield sufficient data for investment planning. They include: the Advanced Chemical Propulsion Assessment; an Advanced Chemical Propulsion System Model; a LOx-LH2 small pumps conceptual design; a space storables propellant study; a spacecraft cryogenic propulsion study; an advanced pressurization and mixture ratio control study; and a pump-fed vs. pressure-fed study.

Knowledge system and method for simulating chemical controlled release device performance

DOEpatents

Cowan, Christina E.; Van Voris, Peter; Streile, Gary P.; Cataldo, Dominic A.; Burton, Frederick G.

1991-01-01

A knowledge system for simulating the performance of a controlled release device is provided. The system includes an input device through which the user selectively inputs one or more data parameters. The data parameters comprise first parameters including device parameters, media parameters, active chemical parameters and device release rate; and second parameters including the minimum effective inhibition zone of the device and the effective lifetime of the device. The system also includes a judgemental knowledge base which includes logic for 1) determining at least one of the second parameters from the release rate and the first parameters and 2) determining at least one of the first parameters from the other of the first parameters and the second parameters. The system further includes a device for displaying the results of the determinations to the user.

Chemical Transformation System: Cloud Based Cheminformatic Services to Support Integrated Environmental Modeling (proceedings)

EPA Science Inventory

Integrated Environmental Modeling (IEM) systems that account for the fate/transport of organics frequently require physicochemical properties as well as transformation products. A myriad of chemical property databases exist but these can be difficult to access and often do not co...

CONCEPTUAL FRAMEWORK FOR THE CHEMICAL EFFECTS IN BIOLOGICAL SYSTEMS (CEBS) TOXICOGENOMICS KNOWLEDGE BASE

EPA Science Inventory

Conceptual Framework for the Chemical Effects in Biological Systems (CEBS) T oxicogenomics Knowledge Base

Abstract
Toxicogenomics studies how the genome is involved in responses to environmental stressors or toxicants. It combines genetics, genome-scale mRNA expressio...

Dynamics of the stochastic low concentration trimolecular oscillatory chemical system with jumps

NASA Astrophysics Data System (ADS)

Wei, Yongchang; Yang, Qigui

2018-06-01

This paper is devoted to discern long time dynamics through the stochastic low concentration trimolecular oscillatory chemical system with jumps. By Lyapunov technique, this system is proved to have a unique global positive solution, and the asymptotic stability in mean square of such model is further established. Moreover, the existence of random attractor and Lyapunov exponents are obtained for the stochastic homeomorphism flow generated by the corresponding global positive solution. And some numerical simulations are given to illustrate the presented results.

Chemical energy storage: Part of a systemic solution

NASA Astrophysics Data System (ADS)

Schlögl, Robert

2017-07-01

This paper is a primer into concepts and opportunities of chemical energy storage. Starting from the quest for decarbonisation we reveal the possibilities of chemical energy storage. We briefly discuss the critical role of catalysis as enabling technology. We concentrate on options of large-scale production of chemicals from CO2 and green hydrogen. We discuss one potential application of fueling future combustion engines that could run with minimal regulated emissions without exhaust purifications and legal tricks.

Joint Chemical Agent Detector (JCAD): the future of chemical agent detection

NASA Astrophysics Data System (ADS)

Laljer, Charles E.; Owen, Jeffery L.

2002-06-01

The Joint Chemical Agent Detector (JCAD) will provide state of the art chemical warfare agent detection capability to ground vehicle operators. Intelligence sources estimate that over twenty counties have active chemical weapons programs. The spread of chemical weapons to third world nations, coupled with the potential for US involvement in these areas in an operational or support capacity, increases the probability that the Joint Services may encounter chemical agents and toxic industrial materials anywhere in the world. Currently, fielded chemical agent detectors are bulky, labor intensive, and subject to false readings. No legacy detector is sensitive enough to provide detection and warning of the low dose hazards associated with miosis contamination. The JCAD will provide a small, lightweight chemical agent detector for vehicle interiors, aircraft, individual personnel, shipboard, and fixed site locations. The system provides a common detection components across multi-service platforms. This common detector system will allow the Joint Services to use the same operational and support concept for more efficient utilization of resources. The JCAD will detect, identify, quantify, and warn of the presence of chemical agents prior to onset of miosis. Upon detection of chemical agents, the detector will provide local and remote audible and visual alarms to the operators. Advance warning will provide the vehicle crew with the time necessary to protect themselves from the lethal effects of chemical agents. The JCAD will also be capable of being upgraded to protect against future chemical agent threats. The JCAD will provide the vehicle operators with the warning necessary to survive and fight in a chemical warfare agent threat environment.

Preliminary Evaluation of a Regional Atmospheric Chemical Data Assimilation System for Environmental Surveillance

PubMed Central

Lee, Pius; Liu, Yang

2014-01-01

We report the progress of an ongoing effort by the Air Resources Laboratory, NOAA to build a prototype regional Chemical Analysis System (ARLCAS). The ARLCAS focuses on providing long-term analysis of the three dimensional (3D) air-pollutant concentration fields over the continental U.S. It leverages expertise from the NASA Earth Science Division-sponsored Air Quality Applied Science Team (AQAST) for the state-of-science knowledge in atmospheric and data assimilation sciences. The ARLCAS complies with national operational center requirement protocols and aims to have the modeling system to be maintained by a national center. Meteorology and chemistry observations consist of land-, air- and space-based observed and quality-assured data. We develop modularized testing to investigate the efficacies of the various components of the ARLCAS. The sensitivity testing of data assimilation schemes showed that with the increment of additional observational data sets, the accuracy of the analysis chemical fields also increased incrementally in varying margins. The benefit is especially noted for additional data sets based on a different platform and/or a different retrieval algorithm. We also described a plan to apply the analysis chemical fields in environmental surveillance at the Centers for Disease Control and Prevention. PMID:25514141

Precursors of dangerous substances formed in the loss of control of chemical systems.

PubMed

Cozzani, V; Zanelli, S

1999-03-01

Article 2 of Directive 96/82/EC on the control of major accident hazards caused by dangerous substances requires to consider also the hazards due to the dangerous substances "which it is believed may be generated during loss of control of an industrial chemical process", although no generally accepted guidelines are available for the identification of these substances. In the present study, the accidents involving the unwanted formation of dangerous substances as a consequence of the loss of control of chemical systems were investigated. A specifically developed database was used, containing data on more than 400 of these accidents and on the substances involved. The hazardous substances formed in the accidents and the precursors of these substances were identified. The influence of accident characteristics on the substances formed was investigated. In the context of the application of Directive 96/82/EC, an accident severity index and a hazard rating of the precursors of dangerous substances formed in the accidents were proposed. A lumping approach was used in order to develop schemes for the preliminary identification of substances that may be formed in the loss of control of chemical system. The results of accident analysis were used to test the schemes developed.

Preliminary evaluation of a regional atmospheric chemical data assimilation system for environmental surveillance.

PubMed

Lee, Pius; Liu, Yang

2014-12-01

We report the progress of an ongoing effort by the Air Resources Laboratory, NOAA to build a prototype regional Chemical Analysis System (ARLCAS). The ARLCAS focuses on providing long-term analysis of the three dimensional (3D) air-pollutant concentration fields over the continental U.S. It leverages expertise from the NASA Earth Science Division-sponsored Air Quality Applied Science Team (AQAST) for the state-of-science knowledge in atmospheric and data assimilation sciences. The ARLCAS complies with national operational center requirement protocols and aims to have the modeling system to be maintained by a national center. Meteorology and chemistry observations consist of land-, air- and space-based observed and quality-assured data. We develop modularized testing to investigate the efficacies of the various components of the ARLCAS. The sensitivity testing of data assimilation schemes showed that with the increment of additional observational data sets, the accuracy of the analysis chemical fields also increased incrementally in varying margins. The benefit is especially noted for additional data sets based on a different platform and/or a different retrieval algorithm. We also described a plan to apply the analysis chemical fields in environmental surveillance at the Centers for Disease Control and Prevention.

Design tool for estimating chemical hydrogen storage system characteristics for light-duty fuel cell vehicles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brooks, Kriston P.; Sprik, Samuel J.; Tamburello, David A.

The U.S. Department of Energy (DOE) has developed a vehicle framework model to simulate fuel cell-based light-duty vehicle operation for various hydrogen storage systems. This transient model simulates the performance of the storage system, fuel cell, and vehicle for comparison to DOE’s Technical Targets using four drive cycles/profiles. Chemical hydrogen storage models have been developed for the Framework model for both exothermic and endothermic materials. Despite the utility of such models, they require that material researchers input system design specifications that cannot be easily estimated. To address this challenge, a design tool has been developed that allows researchers to directlymore » enter kinetic and thermodynamic chemical hydrogen storage material properties into a simple sizing module that then estimates the systems parameters required to run the storage system model. Additionally, this design tool can be used as a standalone executable file to estimate the storage system mass and volume outside of the framework model and compare it to the DOE Technical Targets. These models will be explained and exercised with existing hydrogen storage materials.« less

Systems Toxicology of Male Reproductive Development: Profiling 774 Chemicals for Molecular Targets and Adverse Outcomes

PubMed Central

Leung, Maxwell C.K.; Phuong, Jimmy; Baker, Nancy C.; Sipes, Nisha S.; Klinefelter, Gary R.; Martin, Matthew T.; McLaurin, Keith W.; Setzer, R. Woodrow; Darney, Sally Perreault; Judson, Richard S.; Knudsen, Thomas B.

2015-01-01

Background: Trends in male reproductive health have been reported for increased rates of testicular germ cell tumors, low semen quality, cryptorchidism, and hypospadias, which have been associated with prenatal environmental chemical exposure based on human and animal studies. Objective: In the present study we aimed to identify significant correlations between environmental chemicals, molecular targets, and adverse outcomes across a broad chemical landscape with emphasis on developmental toxicity of the male reproductive system. Methods: We used U.S. EPA’s animal study database (ToxRefDB) and a comprehensive literature analysis to identify 774 chemicals that have been evaluated for adverse effects on male reproductive parameters, and then used U.S. EPA’s in vitro high-throughput screening (HTS) database (ToxCastDB) to profile their bioactivity across approximately 800 molecular and cellular features. Results: A phenotypic hierarchy of testicular atrophy, sperm effects, tumors, and malformations, a composite resembling the human testicular dysgenesis syndrome (TDS) hypothesis, was observed in 281 chemicals. A subset of 54 chemicals with male developmental consequences had in vitro bioactivity on molecular targets that could be condensed into 156 gene annotations in a bipartite network. Conclusion: Computational modeling of available in vivo and in vitro data for chemicals that produce adverse effects on male reproductive end points revealed a phenotypic hierarchy across animal studies consistent with the human TDS hypothesis. We confirmed the known role of estrogen and androgen signaling pathways in rodent TDS, and importantly, broadened the list of molecular targets to include retinoic acid signaling, vascular remodeling proteins, G-protein coupled receptors (GPCRs), and cytochrome P450s. Citation: Leung MC, Phuong J, Baker NC, Sipes NS, Klinefelter GR, Martin MT, McLaurin KW, Setzer RW, Darney SP, Judson RS, Knudsen TB. 2016. Systems toxicology of male

Chemical treatment costs reduced with use of in-pond raceway systems compared to traditional pond aquaculture

USDA-ARS?s Scientific Manuscript database

Production systems such as in-pond raceway systems (IPRS) and split ponds are providing an alternative to traditional pond culture for raising catfish in several southeastern states. One advantage noted by farmers utilizing these systems is the reduced cost associated with the chemical treatment of ...

Chemically modified carbonic anhydrases useful in carbon capture systems

DOEpatents

Novick, Scott; Alvizo, Oscar

2013-01-15

The present disclosure relates to chemically modified carbonic anhydrase polypeptides and soluble compositions, homogenous liquid formulations comprising them. The chemically modified carbonic anhydrase polypeptides have improved properties relative to the same carbonic anhydrase polypeptide that is not chemically modified including the improved properties of increased activity and/or stability in the presence of amine compounds, ammonia, or carbonate ion. The present disclosure also provides methods of preparing the chemically modified polypeptides and methods of using the chemically modified polypeptides for accelerating the absorption of carbon dioxide from a gas stream into a solution as well as for the release of the absorbed carbon dioxide for further treatment and/or sequestering.

Chemically modified carbonic anhydrases useful in carbon capture systems

DOEpatents

Novick, Scott J; Alvizo, Oscar

2013-10-29

The present disclosure relates to chemically modified carbonic anhydrase polypeptides and soluble compositions, homogenous liquid formulations comprising them. The chemically modified carbonic anhydrase polypeptides have improved properties relative to the same carbonic anhydrase polypeptide that is not chemically modified including the improved properties of increased activity and/or stability in the presence of amine compounds, ammonia, or carbonate ion. The present disclosure also provides methods of preparing the chemically modified polypeptides and methods of using the chemically modified polypeptides for accelerating the absorption of carbon dioxide from a gas stream into a solution as well as for the release of the absorbed carbon dioxide for further treatment and/or sequestering.

Remediation System Evaluation, Silresim Chemical Corp. Superfund Site

EPA Pesticide Factsheets

The Silresim Superfund Site is located in an industrial area of Lowell, Massachusetts. This Superfund siteaddresses contamination associated with a chemical waste reclamation facility that was operated bySilresim Chemical Corporation between 1971 and..

A non-chemical system for online weed control.

PubMed

Rueda-Ayala, Victor; Peteinatos, Gerassimos; Gerhards, Roland; Andújar, Dionisio

2015-03-30

Non-chemical weed control methods need to be directed towards a site-specific weeding approach, in order to be able to compete the conventional herbicide equivalents. A system for online weed control was developed. It automatically adjusts the tine angle of a harrow and creates different levels of intensity: from gentle to aggressive. Two experimental plots in a maize field were harrowed with two consecutive passes. The plots presented from low to high weed infestation levels. Discriminant capabilities of an ultrasonic sensor were used to determine the crop and weed variability of the field. A controlling unit used ultrasonic readings to adjust the tine angle, producing an appropriate harrowing intensity. Thus, areas with high crop and weed densities were more aggressively harrowed, while areas with lower densities were cultivated with a gentler treatment; areas with very low densities or without weeds were not treated. Although the weed development was relatively advanced and the soil surface was hard, the weed control achieved by the system reached an average of 51% (20%-91%), without causing significant crop damage as a result of harrowing. This system is proposed as a relatively low cost, online, and real-time automatic harrow that improves the weed control efficacy, reduces energy consumption, and avoids the usage of herbicide.

A Non-Chemical System for Online Weed Control

PubMed Central

Rueda-Ayala, Victor; Peteinatos, Gerassimos; Gerhards, Roland; Andújar, Dionisio

2015-01-01

Non-chemical weed control methods need to be directed towards a site-specific weeding approach, in order to be able to compete the conventional herbicide equivalents. A system for online weed control was developed. It automatically adjusts the tine angle of a harrow and creates different levels of intensity: from gentle to aggressive. Two experimental plots in a maize field were harrowed with two consecutive passes. The plots presented from low to high weed infestation levels. Discriminant capabilities of an ultrasonic sensor were used to determine the crop and weed variability of the field. A controlling unit used ultrasonic readings to adjust the tine angle, producing an appropriate harrowing intensity. Thus, areas with high crop and weed densities were more aggressively harrowed, while areas with lower densities were cultivated with a gentler treatment; areas with very low densities or without weeds were not treated. Although the weed development was relatively advanced and the soil surface was hard, the weed control achieved by the system reached an average of 51% (20%–91%), without causing significant crop damage as a result of harrowing. This system is proposed as a relatively low cost, online, and real-time automatic harrow that improves the weed control efficacy, reduces energy consumption, and avoids the usage of herbicide. PMID:25831085

Low thrust chemical orbit to orbit propulsion system propellant management study

NASA Technical Reports Server (NTRS)

Dergance, R. H.; Hamlyn, K. M.; Tegart, J. R.

1981-01-01

Low thrust chemical propulsion systems were sized for transfer of large space systems from LEO to GEO. The influence of propellant combination, tankage and insulation requirements, and propellant management techniques on the LTPS mass and volume were studied. Liquid oxygen combined with hydrogen, methane or kerosene were the propellant combinations. Thrust levels of 445, 2230, and 4450 N were combined with 1, 4 and 8 perigee burn strategies. This matrix of systems was evaluated using multilayer insulation and spray-on-foam insulation systems. Various combinations of toroidal, cylindrical with ellipsoidal domes, and ellipsoidal tank shapes were investigated. Results indicate that low thrust (445 N) and single perigee burn approaches are considerably less efficient than the higher thrust level and multiple burn strategies. A modified propellant settling approach minimized propellant residuals and decreased system complexity, in addition, the toroid/ellipsoidal tank combination was predicted to be shortest.

Systems metabolic engineering of microorganisms for natural and non-natural chemicals.

PubMed

Lee, Jeong Wook; Na, Dokyun; Park, Jong Myoung; Lee, Joungmin; Choi, Sol; Lee, Sang Yup

2012-05-17

Growing concerns over limited fossil resources and associated environmental problems are motivating the development of sustainable processes for the production of chemicals, fuels and materials from renewable resources. Metabolic engineering is a key enabling technology for transforming microorganisms into efficient cell factories for these compounds. Systems metabolic engineering, which incorporates the concepts and techniques of systems biology, synthetic biology and evolutionary engineering at the systems level, offers a conceptual and technological framework to speed the creation of new metabolic enzymes and pathways or the modification of existing pathways for the optimal production of desired products. Here we discuss the general strategies of systems metabolic engineering and examples of its application and offer insights as to when and how each of the different strategies should be used. Finally, we highlight the limitations and challenges to be overcome for the systems metabolic engineering of microorganisms at more advanced levels.

Theoretical calculations of physico-chemical and spectroscopic properties of bioinorganic systems: current limits and perspectives.

PubMed

Rokob, Tibor András; Srnec, Martin; Rulíšek, Lubomír

2012-05-21

In the last decade, we have witnessed substantial progress in the development of quantum chemical methodologies. Simultaneously, robust solvation models and various combined quantum and molecular mechanical (QM/MM) approaches have become an integral part of quantum chemical programs. Along with the steady growth of computer power and, more importantly, the dramatic increase of the computer performance to price ratio, this has led to a situation where computational chemistry, when exercised with the proper amount of diligence and expertise, reproduces, predicts, and complements the experimental data. In this perspective, we review some of the latest achievements in the field of theoretical (quantum) bioinorganic chemistry, concentrating mostly on accurate calculations of the spectroscopic and physico-chemical properties of open-shell bioinorganic systems by wave-function (ab initio) and DFT methods. In our opinion, the one-to-one mapping between the calculated properties and individual molecular structures represents a major advantage of quantum chemical modelling since this type of information is very difficult to obtain experimentally. Once (and only once) the physico-chemical, thermodynamic and spectroscopic properties of complex bioinorganic systems are quantitatively reproduced by theoretical calculations may we consider the outcome of theoretical modelling, such as reaction profiles and the various decompositions of the calculated parameters into individual spatial or physical contributions, to be reliable. In an ideal situation, agreement between theory and experiment may imply that the practical problem at hand, such as the reaction mechanism of the studied metalloprotein, can be considered as essentially solved.

A versatile soft X-ray transmission system for time resolved in situ microscopy with chemical contrast.

PubMed

Forsberg, J; Englund, C-J; Duda, L-C

2009-08-01

We present the design and operation of a versatile soft X-ray transmission system for time resolved in situ microscopy with chemical contrast. The utility of the setup is demonstrated by results from following a corrosion process of iron in saline environment, subjected to a controlled humid atmosphere. The system includes a transmission flow-cell reactor that allows for in situ microscopic probing with soft X-rays. We employ a full field technique by using a nearly collimated X-ray beam that produces an unmagnified projection of the transmitted soft X-rays (below 1.1 keV) which is magnified and recorded by an optical CCD camera. Time lapse series with chemical contrast allow us to follow and interpret the chemical processes in detail. The obtainable lateral resolution is a few mum, sufficient to detect filiform corrosion on iron.

Gas chromatograph-mass spectrometer (GC/MS) system for quantitative analysis of reactive chemical compounds

DOEpatents

Grindstaff, Quirinus G.

1992-01-01

Described is a new gas chromatograph-mass spectrometer (GC/MS) system and method for quantitative analysis of reactive chemical compounds. All components of such a GC/MS system external to the oven of the gas chromatograph are programmably temperature controlled to operate at a volatilization temperature specific to the compound(s) sought to be separated and measured.

[Legal aspects of the REACH regulation. The control system of the REACH regulation--new approaches in the EU chemical legislation].

PubMed

Pache, Eckhard

2008-12-01

The REACH regulation from 2006 shall overcome the deficiencies of the previously existing inconsistent legal system of chemicals and build an efficient and innovative regulation for industrial chemicals in the EU. For this purpose, the REACH regulation is not inventing a completely new legislation for chemical substances, but refers to the existing rules, regulates and structures them in a new manner and complements them. With REACH a consistent control system for chemicals in Europe has been created, which basically is managed and coordinated by the newly established European Chemicals Agency (ECHA). In the first phases of the REACH system, information about chemicals is generated and afterwards evaluated. Then this information is used in a process of authorization and restriction, to ensure adequate proliferation and safe exposure to chemical substances. Numerous duties to furnish information complement the readjustment's procedural steps, particularly with regard to the supply chain and down to the consumer. It is mainly affected by the abrogation of the determination between new and existing substances, the principle of substitution and is based on the idea that industry itself is best suited to ensure that the substances it manufactures and places on the market in the EU do not adversely affect human health or the environment.

DEMONSTRATION BULLETIN: X*TRAX MODEL 200 THERMAL DESORPTION SYSTEMS - CHEMICAL WASTE MANAGEMENT, INC.

EPA Science Inventory

The X*TRAX™ Mode! 200 Thermal Desorption System developed by Chemical Waste Management, Inc. (CWM), is a low-temperature process designed to separate organic contaminants from soils, sludges, and other solid media. The X*TRAX™ Model 200 is fully transportable and consists of thre...

Quantum chemical methods for the investigation of photoinitiated processes in biological systems: theory and applications.