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Sample records for affective loop experiences

  1. Affective loop experiences: designing for interactional embodiment

    PubMed Central

    Höök, Kristina

    2009-01-01

    Involving our corporeal bodies in interaction can create strong affective experiences. Systems that both can be influenced by and influence users corporeally exhibit a use quality we name an affective loop experience. In an affective loop experience, (i) emotions are seen as processes, constructed in the interaction, starting from everyday bodily, cognitive or social experiences; (ii) the system responds in ways that pull the user into the interaction, touching upon end users' physical experiences; and (iii) throughout the interaction the user is an active, meaning-making individual choosing how to express themselves—the interpretation responsibility does not lie with the system. We have built several systems that attempt to create affective loop experiences with more or less successful results. For example, eMoto lets users send text messages between mobile phones, but in addition to text, the messages also have colourful and animated shapes in the background chosen through emotion-gestures with a sensor-enabled stylus pen. Affective Diary is a digital diary with which users can scribble their notes, but it also allows for bodily memorabilia to be recorded from body sensors mapping to users' movement and arousal and placed along a timeline. Users can see patterns in their bodily reactions and relate them to various events going on in their lives. The experiences of building and deploying these systems gave us insights into design requirements for addressing affective loop experiences, such as how to design for turn-taking between user and system, how to create for ‘open’ surfaces in the design that can carry users' own meaning-making processes, how to combine modalities to create for a ‘unity’ of expression, and the importance of mirroring user experience in familiar ways that touch upon their everyday social and corporeal experiences. But a more important lesson gained from deploying the systems is how emotion processes are co-constructed and

  2. Affective loop experiences: designing for interactional embodiment.

    PubMed

    Höök, Kristina

    2009-12-12

    Involving our corporeal bodies in interaction can create strong affective experiences. Systems that both can be influenced by and influence users corporeally exhibit a use quality we name an affective loop experience. In an affective loop experience, (i) emotions are seen as processes, constructed in the interaction, starting from everyday bodily, cognitive or social experiences; (ii) the system responds in ways that pull the user into the interaction, touching upon end users' physical experiences; and (iii) throughout the interaction the user is an active, meaning-making individual choosing how to express themselves-the interpretation responsibility does not lie with the system. We have built several systems that attempt to create affective loop experiences with more or less successful results. For example, eMoto lets users send text messages between mobile phones, but in addition to text, the messages also have colourful and animated shapes in the background chosen through emotion-gestures with a sensor-enabled stylus pen. Affective Diary is a digital diary with which users can scribble their notes, but it also allows for bodily memorabilia to be recorded from body sensors mapping to users' movement and arousal and placed along a timeline. Users can see patterns in their bodily reactions and relate them to various events going on in their lives. The experiences of building and deploying these systems gave us insights into design requirements for addressing affective loop experiences, such as how to design for turn-taking between user and system, how to create for 'open' surfaces in the design that can carry users' own meaning-making processes, how to combine modalities to create for a 'unity' of expression, and the importance of mirroring user experience in familiar ways that touch upon their everyday social and corporeal experiences. But a more important lesson gained from deploying the systems is how emotion processes are co-constructed and experienced

  3. Closed-loop neurostimulation: the clinical experience.

    PubMed

    Sun, Felice T; Morrell, Martha J

    2014-07-01

    Neurostimulation is now an established therapy for the treatment of movement disorders, pain, and epilepsy. While most neurostimulation systems available today provide stimulation in an open-loop manner (i.e., therapy is delivered according to preprogrammed settings and is unaffected by changes in the patient's clinical symptoms or in the underlying disease), closed-loop neurostimulation systems, which modulate or adapt therapy in response to physiological changes, may provide more effective and efficient therapy. At present, few such systems exist owing to the complexities of designing and implementing implantable closed-loop systems. This review focuses on the clinical experience of four implantable closed-loop neurostimulation systems: positional-adaptive spinal cord stimulation for treatment of pain, responsive cortical stimulation for treatment of epilepsy, closed-loop vagus nerve stimulation for treatment of epilepsy, and concurrent sensing and stimulation for treatment of Parkinson disease. The history that led to the development of the closed-loop systems, the sensing, detection, and stimulation technology that closes the loop, and the clinical experiences are presented.

  4. Catheterization of Intestinal Loops in Ruminants Does Not Adversely Affect Loop Function

    PubMed Central

    Inglis, G Douglas; Kastelic, John P; Uwiera, Richard R E

    2010-01-01

    Catheterized intestinal loops may be a valuable model to elucidate key components of the host response to various treatments within the small intestine of ruminants. We examined whether catheterizing ileal loops in sheep affected the overall health of animals and intestinal function, whether a bacterial treatment could be introduced into the loops through the catheters, and whether broad-spectrum antibiotics could sterilize the loops. Escherichia coli cells transformed to express the GFP gene were introduced readily into the loops through the catheters, and GFP E. coli cells were localized within the injected loops. Catheterized loops, interspaces, and intact ileum exhibited no abnormalities in tissue appearance or electrical resistance. Expression of the IFNγ, IL1α, IL4, IL6, IL12p40, IL18, TGFβ1, and TNFα cytokine genes did not differ significantly among the intact ileum, catheterized loops, and interspaces, nor did the expression of the gene for inducible nitric oxide synthase. Broad-spectrum antibiotics administered during surgery did not sterilize the loops or interspaces and did not substantively change the composition of the microbiota. However, antibiotics reduced the overall number of bacterial cells within the loop and the relative abundance of community constituents. We concluded that catheterization of intestinal loops did not adversely affect health or loop function in sheep. Furthermore, allowing animals to recover fully from surgery and to clear pharmaceuticals will remove any confounding effects due to these factors, making catheterized intestinal loops a feasible model for studying host responses in ruminants. PMID:21262134

  5. Operation Experience of LBE Loop: HELIOS

    SciTech Connect

    Seung Ho, Jeong; Chi Bum, Bahn; Seung Hee, Chang; Young Jin, Oh; Won Chang, Nam; Kyung Ha, Ryu; Hyo On, Nam; Jun, Lim; Tai Hyun, Lee; Seung Gi, Lee; Na Young, Lee; Il Soon, Hwang

    2006-07-01

    An LBE (lead-bismuth eutectic) coolant loop, named as HELIOS (Heavy Eutectic liquid metal Loop for Investigation of Operability and Safety of PEACER), has been designed by thermal-hydraulic scaling of the PEACER-300MW{sub e} (Proliferation-resistant, Environment-friendly, Accident-tolerant, Continuable and Economical Reactor). HELIOS is consisted of an electrically-heated core at its bottom and a heat exchanger at its top with their mean elevation difference of 8 meter, closely matching with that of PEACER. Natural circulation experiment and material test are principal goals of HELIOS operation. About 2 metric ton of LBE is circulated by a centrifugal pump at a rate up to 76 liter/min through HELIOS having a total 12 meter height. A material test bypass was installed to perform LBE corrosion experiments in continuous operation conditions at temperature and flow velocity higher than nominal values. During the initial start-up test, there was an accidental cooling water leak into LBE at around 250 deg C, but without any consequences. A small LBE leak occurred through a crack in a bellows for connecting storage tank to the main loop, apparently due to excessive stress arisen from faulty installation, however, there was no significant safety hazard or chemical reaction with environment. Many practical difficulties arouse with sensors for pressure measurement, level control in sump pump tank. LBE loop operation experiences are summarized herein. Upon the sensor calibrations, HELIOS will be utilized to examine the materials durability and natural circulation capability of PEACER-300. (authors)

  6. Affective Productions of Mathematical Experience

    ERIC Educational Resources Information Center

    Walshaw, Margaret; Brown, Tony

    2012-01-01

    In underscoring the affective elements of mathematics experience, we work with contemporary readings of the work of Spinoza on the politics of affect, to understand what is included in the cognitive repertoire of the Subject. We draw on those resources to tell a pedagogical tale about the relation between cognition and affect in settings of…

  7. Flight Testing of the Capillary Pumped Loop 3 Experiment

    NASA Technical Reports Server (NTRS)

    Ottenstein, Laura; Butler, Dan; Ku, Jentung; Cheung, Kwok; Baldauff, Robert; Hoang, Triem

    2002-01-01

    The Capillary Pumped Loop 3 (CAPL 3) experiment was a multiple evaporator capillary pumped loop experiment that flew in the Space Shuttle payload bay in December 2001 (STS-108). The main objective of CAPL 3 was to demonstrate in micro-gravity a multiple evaporator capillary pumped loop system, capable of reliable start-up, reliable continuous operation, and heat load sharing, with hardware for a deployable radiator. Tests performed on orbit included start-ups, power cycles, low power tests (100 W total), high power tests (up to 1447 W total), heat load sharing, variable/fixed conductance transition tests, and saturation temperature change tests. The majority of the tests were completed successfully, although the experiment did exhibit an unexpected sensitivity to shuttle maneuvers. This paper describes the experiment, the tests performed during the mission, and the test results.

  8. Estimating two-loop radiative effects in the MOLLER experiment

    SciTech Connect

    Aleksejevs, A. G.; Barkanova, S. G.; Zykunov, V. A.; Kuraev, E. A.

    2013-07-15

    Within the on-shell renormalization scheme, two-loop electroweak corrections to the parityviolating polarization asymmetry in the reaction e{sup -}e{sup -} {yields} e{sup -}e{sup -}({gamma}, {gamma}{gamma}) were estimated for the MOLLER experiment at JLab. The infrared divergence and the imaginary part of the amplitude were taken completely under control. Relevant compact expressions obtained by using asymptotic methods are free from unphysical parameters and are convenient for analysis and for numerical estimations. A numerical analysis revealed a significant scale of two-loop effects and the need for taking them into account in the MOLLER experiment.

  9. Closed-Loop HIRF Experiments Performed on a Fault Tolerant Flight Control Computer

    NASA Technical Reports Server (NTRS)

    Belcastro, Celeste M.

    1997-01-01

    ABSTRACT Closed-loop HIRF experiments were performed on a fault tolerant flight control computer (FCC) at the NASA Langley Research Center. The FCC used in the experiments was a quad-redundant flight control computer executing B737 Autoland control laws. The FCC was placed in one of the mode-stirred reverberation chambers in the HIRF Laboratory and interfaced to a computer simulation of the B737 flight dynamics, engines, sensors, actuators, and atmosphere in the Closed-Loop Systems Laboratory. Disturbances to the aircraft associated with wind gusts and turbulence were simulated during tests. Electrical isolation between the FCC under test and the simulation computer was achieved via a fiber optic interface for the analog and discrete signals. Closed-loop operation of the FCC enabled flight dynamics and atmospheric disturbances affecting the aircraft to be represented during tests. Upset was induced in the FCC as a result of exposure to HIRF, and the effect of upset on the simulated flight of the aircraft was observed and recorded. This paper presents a description of these closed- loop HIRF experiments, upset data obtained from the FCC during these experiments, and closed-loop effects on the simulated flight of the aircraft.

  10. Capillary pumped loop GAS and Hitchhiker flight experiments

    NASA Technical Reports Server (NTRS)

    Ku, J.; Kroliczek, E. J.; Butler, D.; Schweickart, R. B.; Mcintosh, R.

    1986-01-01

    Flight experiments of a capillary pumped loop (CPL) aboard the Space Shuttle on both the Get Away Special (GAS) and Hitchhiker-G (H/H-G) carriers are described. These tests have shown that a two-phase heat transfer loop utilizing a wicking material as the system pumping mechanism can operate successfully in a zero-g environment. The CPL operating modes demonstrated were start-up, heat load sharing/natural priming, liquid inventory and temperature control via the reservoir, dryout recovery, and isolation of a single pump deprime. Also investigated were high and low power limits, and inlet subcooling requirements. In these CPL flight experiments, successful system operation was demonstrated at input power levels up to 560 watts and inlet subcooling below 2 C.

  11. Flight testing of the Capillary Pumped Loop Flight Experiment

    NASA Technical Reports Server (NTRS)

    Butler, Dan; Ottenstein, Laura; Ku, Jentung

    1995-01-01

    The Capillary Pumped Loop Flight Experiment (CAPL) employs a passive two-phase thermal control system that uses the latent heat of vaporization of ammonia to transfer heat over long distances. CAPL was designed as a prototype of the Earth Observing System (EOS) instrument thermal control systems. The purpose of the mission was to provide validation of the system performance in micro-gravity, prior to implementation on EOS. CAPL was flown on STS-60 in February, 1994, with some unexpected results related to gravitational effects on two-phase systems. Flight test results and post flight investigations will be addressed, along with a brief description of the experiment design.

  12. THE ROLE OF ACTIVE REGION LOOP GEOMETRY. I. HOW CAN IT AFFECT CORONAL SEISMOLOGY?

    SciTech Connect

    Selwa, M.; Ofman, L.; Solanki, S. K. E-mail: leon.ofman@nasa.gov

    2011-01-01

    We present numerical results of coronal loop oscillation excitation using a three-dimensional (3D) MHD model of an idealized active region (AR) field. The AR is initialized as a potential dipole magnetic configuration with gravitationally stratified density and contains a loop with a higher density than its surroundings. We study different ways of excitation of vertical kink oscillations of this loop by velocity: as an initial condition, and as an impulsive excitation with a pulse of a given position, duration, and amplitude. We vary the geometry of the loop in the 3D MHD model and find that it affects both the period of oscillations and the synthetic observations (difference images) that we get from oscillations. Due to the overestimated effective length of the loop in the case of loops which have maximum separation between their legs above the footpoints (>50% of observed loops), the magnetic field obtained from coronal seismology can also be overestimated. The 3D MHD model shows how the accuracy of magnetic field strength determined from coronal seismology can be improved. We study the damping mechanism of the oscillations and find that vertical kink waves in 3D stratified geometry are damped mainly due to wave leakage in the horizontal direction.

  13. Stem-loop RNA labeling can affect nuclear and cytoplasmic mRNA processing.

    PubMed

    Heinrich, Stephanie; Sidler, Corinne L; Azzalin, Claus M; Weis, Karsten

    2017-02-01

    The binding of sequence-specific RNA-interacting proteins, such as the bacteriophage MS2 or PP7 coat proteins, to their corresponding target sequences has been extremely useful and widely used to visualize single mRNAs in vivo. However, introduction of MS2 stem-loops into yeast mRNAs has recently been shown to lead to the accumulation of RNA fragments, suggesting that the loops impair mRNA decay. This result was questioned, because fragment occurrence was mainly assessed using ensemble methods, and their cellular localization and its implications had not been addressed on a single transcript level. Here, we demonstrate that the introduction of either MS2 stem-loops (MS2SL) or PP7 stem-loops (PP7SL) can affect the processing and subcellular localization of mRNA. We use single-molecule fluorescence in situ hybridization (smFISH) to determine the localization of three independent mRNAs tagged with the stem-loop labeling systems in glucose-rich and glucose starvation conditions. Transcripts containing MS2SL or PP7SL display aberrant localization in both the nucleus and the cytoplasm. These defects are most prominent in glucose starvation conditions, with nuclear mRNA processing being altered and stem-loop fragments abnormally enriching in processing bodies (PBs). The mislocalization of SL-containing RNAs is independent of the presence of the MS2 or PP7 coat protein (MCP or PCP).

  14. The experience sampling method: Investigating students' affective experience

    NASA Astrophysics Data System (ADS)

    Nissen, Jayson M.; Stetzer, MacKenzie R.; Shemwell, Jonathan T.

    2013-01-01

    Improving non-cognitive outcomes such as attitudes, efficacy, and persistence in physics courses is an important goal of physics education. This investigation implemented an in-the-moment surveying technique called the Experience Sampling Method (ESM) [1] to measure students' affective experience in physics. Measurements included: self-efficacy, cognitive efficiency, activation, intrinsic motivation, and affect. Data are presented that show contrasts in students' experiences (e.g., in physics vs. non-physics courses).

  15. Activity of Crohn's disease assessed by colour Doppler ultrasound analysis of the affected loops.

    PubMed

    Esteban, J M; Maldonado, L; Sanchiz, V; Minguez, M; Benages, A

    2001-01-01

    The aim of this study was to evaluate with colour Doppler ultrasound the vascular changes in the wall of the loops affected by Crohn's disease, and to establish whether these changes reflects clinical or biochemical activity of Crohn's disease. Seventy-nine patients with Crohn's disease (44 with active disease and 35 inactive patients) were studied with frequency- and amplitude-encoded duplex Doppler sonography. A group of 35 healthy volunteers were also included. The exam consisted of the search for colour signals in the walls of the loops affected by Crohn's disease, classifying the degree of vascularity with a simple scoring system into three groups: absence of colour signal (score of 0); weak or scattered colour signals (score of 1); and multiple colour signals or clear identification of vessels in the loops walls (score of 2). Doppler curves were obtained of the detected vessels with measurement of the resistive index (RI). There was a visible increase in the gut walls' vascularity in the active patients compared with those with inactive disease. The mean RI was statistically significantly lower in the gut wall vessels of the patients with active illness than that obtained in the inactive patients. Colour Doppler ultrasound is a useful tool in the assessment of activity in Crohn's disease.

  16. Open-Loop HIRF Experiments Performed on a Fault Tolerant Flight Control Computer

    NASA Technical Reports Server (NTRS)

    Koppen, Daniel M.

    1997-01-01

    During the third quarter of 1996, the Closed-Loop Systems Laboratory was established at the NASA Langley Research Center (LaRC) to study the effects of High Intensity Radiated Fields on complex avionic systems and control system components. This new facility provided a link and expanded upon the existing capabilities of the High Intensity Radiated Fields Laboratory at LaRC that were constructed and certified during 1995-96. The scope of the Closed-Loop Systems Laboratory is to place highly integrated avionics instrumentation into a high intensity radiated field environment, interface the avionics to a real-time flight simulation that incorporates aircraft dynamics, engines, sensors, actuators and atmospheric turbulence, and collect, analyze, and model aircraft performance. This paper describes the layout and functionality of the Closed-Loop Systems Laboratory, and the open-loop calibration experiments that led up to the commencement of closed-loop real-time flight experiments.

  17. Experiment to Study Alfven Wave Propagation in Plasma Loops

    NASA Astrophysics Data System (ADS)

    Kendall, Mark; Bellan, Paul

    2010-11-01

    Arched plasma-filled twisted magnetic flux tubes are generated in the laboratory using pulsed power techniques (J.F. Hansen, S.K.P. Tripathi, P.M. Bellan, 2004). Their structure and time evolution exhibit similarities with both solar coronal loops and spheromaks. We are now developing a method to excite propagating torsional Alfven wave modes in such plasma loops by superposing a ˜10kA, ˜100ns current pulse upon the ˜50kA, 10μs main discharge current that flows along the ˜20cm long, 2cm diameter arched flux tube. To achieve this high power 100ns pulse, a magnetic pulse compression technique based on saturable reactors is employed. A low power prototype has been successfully tested, and design and construction of a full-power device is nearing completion. The full-power device will compress an initial 2μs pulse by a factor of nearly 20; the final stage utilizes a water-filled transmission line with ultra-low inductance to attain the final timescale. This new pulse device will subsequently be used to investigate interactions between Alfven waves and the larger-scale loop evolution; one goal will be to directly image the wave using high-speed photography. Attention will be paid to wave propagation including dispersion and reflection, as well as dissipation mechanisms and possible energetic particle generation.

  18. A Loop Current experiment: Field and remote measurements

    NASA Astrophysics Data System (ADS)

    Hamilton, Peter; Lugo-Fernández, Alexis; Sheinbaum, Julio

    2016-12-01

    An overview of a new comprehensive observational study of the Loop Current (LC) in the eastern Gulf of Mexico that encompassed full-depth and near-bottom moorings, pressure-equipped inverted echo sounders (PIES) and remote sensing is presented. The study array was designed to encompass the LC from the Campeche Bank to the west Florida escarpment. This overview centers about principal findings as they pertain to mesoscale dynamics. Two companion papers provide in-depth analyses. Three LC anticyclonic eddy separation events were observed with good 3D spatial coverage over the 2½ year extent of the field study; the three separations exhibited similar processes after the LC had extended into the eastern Gulf. Large scale (∼300 km wavelength, 40-60 day periods) southward propagating meanders developed on the eastern side of the LC over deep (∼3000 m) water that were the result of baroclinic instability between the upper layer meandering jet and lower layer cyclones and anticyclones. The lower layer was only highly energetic during relatively short (∼2-3 months) intervals just prior to or during eddy detachments because of baroclinic instability. The steepening of the meanders lead to a pinch-off of LC eddies. The deep lower-layer eddies, constrained by the closed topography of the southeastern Gulf, propagated westward across the detachment zone and appear to assist in achieving separation. Small scale (∼50-100 km, periods ∼10 days) frontal eddies, observed on the western side of the LC along the Campeche Bank slope, decay over the deep water of the northern part of an extended LC, and have little influence on lower layer eddies, the east side meanders and the eddy detachment processes.

  19. Experimental and analytical studies of merging plasma loops on the Caltech solar loop experiment

    NASA Astrophysics Data System (ADS)

    Pitigoi-Aron, Gabriela

    and personal factors and perceptions with emphasis on mentors' influence; (5) Negative influence of salary difference with respect to private practitioners. The findings of this study were similar to the available studies on foreign-trained dentists and to most of the studies already done on domestically trained dentists. The major factors found were comparable with the up-to-date literature. The elevated research drive, the intellectual challenges, the work environment, the desire to teach, and the mentors' influence were among those which mirrored almost perfectly the other studies. Some fine differences were found for foreign-trained dentists, such as a lighter financial burden caused by smaller student debt and the irrelevance of military practice experience. The study provides a number of suggestions for enhancing the recruiting and retaining process for dental academia: (1) Support and enhance the research capacity of dental schools; (2) Create structures to develop mentors; (3) Invest to build prestige; (4) Find creative ways to offset lower salaries; (5) Foster a pleasant academic working environment; (6) Use international activities to recruit international dentists. The study revealed factors that have been influential in participants' decisions to choose an academic career, in general and at Pacific. It is hoped that this study will be a useful reference in the increasingly difficult endeavor of adding and retaining world-class dental educators.

  20. Pilot-in-the-Loop Analysis of Aileron Operation and Flight Simulator Experiments

    NASA Astrophysics Data System (ADS)

    Fujinaga, Jin; Tokutake, Hiroshi; Miura, Yumiko

    Lateral-directional piloted simulation experiments were conducted in order to analyze pilot responses when the pilot controls an aircraft with only the ailerons after rudder failure. The experiments were carried out using a fixed-base flight simulator and four pilots. Six aircraft configurations, made by changing the stability derivatives, were tested, and pilot models were identified using the least-squares method. An analysis of the closed-loop shows that the closed-loop gain and stabilities correlate with the tracking error of the compensation task. Additionally, from the results of analysis, an evaluation function using pilot-in-the-loop with a fixed pilot model was developed. This function was able to predict the compensational error analytically from the airplane dynamics.

  1. Three tritium systems test assembly (TSTA) off-loop experiments

    SciTech Connect

    Talcott, C.L.; Anderson, J.L.; Carlson, R.V.; Coffin, D.O.; Walthers, C.R.; Hamerdinger, D.; Binning, K.; Trujillo, R.D.; Moya, J.S.; Hayashi, T.; Okuno, K.; Yamanishi, T.

    1993-11-01

    This report contains the results from three different experiments. Experiment one was initiated to establish the possibility of using a soft elastomer in ITER (International Thermonuclear Experimental Reactor) applications. Used in this application, the sealing material is anticipated to be in tritium at pressures in the range of 1 {times} 10{sup {minus}3} torr for many years. Here two O-ring valve seals each of Viton-A, Buna-N, and EDPM were exposed to 1, 40, or 400 torr of tritium while being cycled open and closed approximately 11,500 times in 192 days. EDPM is the least susceptible to damage from the tritium. Both Buna-N and Viton-A showed deterioration following the first cycling at 400 torr. Using commercially available materials, the Tritium Systems Test Assembly (TSTA) designed and built a Portable Water Removal (PWR) Unit to reduce tritium oxide emissions during glovebox breaches. The PWR removes 99.9% of all tritium and saves between 0.7 and 3.5 curies of tritium oxide from being stacked during each of the five tests. Finally, a series of tests are done to determine whether the presence of SF{sub 6} changes the ability of palladium and platinum to catalyze the T{sub 2}-O{sub 2} reaction to form T{sub 2}O. No deterioration of the catalytic activity is observed. This is important because the Tokamak Fusion Test Reactor (TFTR) requires information about the effect of SF{sub 6}, an electrical insulator, on the catalytic behavior of Pt and Pd in a T{sub 2} environment. This information is necessary for the accident analysis in the Safety Analysis Report for TFTR. This study is done using an apparatus supplied to TSTA by TFTR.

  2. THE ROLE OF AFFECTIVE EXPERIENCE IN WORK MOTIVATION

    PubMed Central

    SEO, MYEONG-GU; BARRETT, LISA FELDMAN; BARTUNEK, JEAN M.

    2005-01-01

    Based on psychological and neurobiological theories of core affective experience, we identify a set of direct and indirect paths through which affective feelings at work affect three dimensions of behavioral outcomes: direction, intensity, and persistence. First, affective experience may influence these behavioral outcomes indirectly by affecting goal level and goal commitment, as well as three key judgment components of work motivation: expectancy judgments, utility judgments, and progress judgments. Second, affective experience may also affect these behavioral outcomes directly. We discuss implications of our model. PMID:16871321

  3. Incidental experiences of affective coherence and incoherence influence persuasion.

    PubMed

    Huntsinger, Jeffrey R

    2013-06-01

    When affective experiences are inconsistent with activated evaluative concepts, people experience what is called affective incoherence; when affective experiences are consistent with activated evaluative concepts, people experience affective coherence. The present research asked whether incidental feelings of affective coherence and incoherence would regulate persuasion. Experiences of affective coherence and incoherence were predicted and found to influence the processing of persuasive messages when evoked prior to receipt of such messages (Experiments 1 and 3), and to influence the confidence with which thoughts generated by persuasive messages were held when evoked after presentation of such messages (Experiments 2 and 3). These results extend research on affective coherence and incoherence by showing that they exert a broader impact on cognitive activity than originally assumed.

  4. Academic Factors that Affect Undergraduate Research Experiences

    ERIC Educational Resources Information Center

    Taraban, Roman; Logue, Erin

    2012-01-01

    Undergraduate research experiences are considered an essential component in college curricula, and there is an ideological push to provide these experiences to all students. However, it is not clear whether engagement in research is better suited for higher ability undergraduates late in their programs or for all undergraduates and whether…

  5. Experiments in a single-phase natural circulation mini-loop

    SciTech Connect

    Misale, M.; Garibaldi, P.; Passos, J.C.; de Bitencourt, G. Ghisi

    2007-08-15

    This study reports an experimental investigation related to a rectangular single-phase natural circulation mini-loop, which consists of two horizontal copper tubes (heat transfer sections) and two vertical tubes (legs) made of copper, connected by means of four glass 90 bends. The loop inner diameter is 4 mm. The lower heating section consists of an electrical heating wire made of nicromel on the outside of the copper tube; the upper cooling system consists of a coaxial cylindrical heat exchanger with a water-glycol mixture, set at controlled temperature and flowing through the annulus. The loop has an imposed heat flux in the lower heating section and an imposed temperature in the cooler. The mini-loop was placed onto a table which can assume different inclinations. The parameters investigated during the experiments were: power transferred to the fluid and inclination of the loop. The preliminary results show a stable behaviour with a steady temperature difference across the heat sinks. It has been confirmed that the fluid velocity is very small (order of millimetres per second). (author)

  6. The Affective Experience of Novice Computer Programmers

    ERIC Educational Resources Information Center

    Bosch, Nigel; D'Mello, Sidney

    2017-01-01

    Novice students (N = 99) participated in a lab study in which they learned the fundamentals of computer programming in Python using a self-paced computerized learning environment involving a 25-min scaffolded learning phase and a 10-min unscaffolded fadeout phase. Students provided affect judgments at approximately 100 points (every 15 s) over the…

  7. Locomotor Experience Affects Self and Emotion

    ERIC Educational Resources Information Center

    Uchiyama, Ichiro; Anderson, David I.; Campos, Joseph J.; Witherington, David; Frankel, Carl B.; Lejeune, Laure; Barbu-Roth, Marianne

    2008-01-01

    Two studies investigated the role of locomotor experience on visual proprioception in 8-month-old infants. "Visual proprioception" refers to the sense of self-motion induced in a static person by patterns of optic flow. A moving room apparatus permitted displacement of an entire enclosure (except for the floor) or the side walls and…

  8. The Capillary Pumped Loop Flight Experiment (CAPL): A pathfinder for EOS

    NASA Technical Reports Server (NTRS)

    Butler, D.; Hoang, T.

    1992-01-01

    The CAPL shuttle flight experiment will provide microgravity verification of the prototype capillary pumped loop (CPL) thermal control system for EOS. The design of the experiment is discussed with particular emphasis on the new technology areas in ammonia two-phase reservior design and heat pipe heat exchanger development. The thermal and hydrodynamic analysis techniques and results are also presented, including pressure losses, fluid flow, and non-orbit heat rejection capability. CAPL experiment results will be presented after the flight, presently planned for 1993.

  9. Development and integration of the capillary pumped loop GAS and Hitchhiker flight experiments

    NASA Technical Reports Server (NTRS)

    Butler, D.; Mcintosh, R.

    1990-01-01

    The Capillary Pumped Loop (CPL) is a thermal control system with high density heat acquisition and transport capability. A small spaceflight version of the CPL was built and flown as a GAS experiment on STS 51-D in April 1985 and STS 51-G in June 1985, and as a Hitchhiker-G experiment on STS 61-C in January 1986. The purpose of the experiments was to demonstrate the capability of a capillary pumped system under microgravity conditions for use in the thermal control of large scientific instruments, advanced orbiting spacecraft, and space station components. The development, integration, and test activities of the CPL are described.

  10. Thermoelectric Converter for Loop Heat Pipe Temperature Control: Experience and Lessons Learned

    NASA Technical Reports Server (NTRS)

    Ku, Jentung; Ottenstein, Laura

    2010-01-01

    This paper describes the theoretical background and implementation methodology of using a thermoelectric converter (TEC) for operating temperature control of a loop heat pipe (LHP). In particular, experimental results from ambient and thermal vacuum tests of an LHP are presented for illustrations. The most commonly used state-of-the-art method to control the LHP operating temperature is to cold bias its compensation chamber (CC) and use an electrical heater to maintain the CC at the desired set point temperature. Although effective, this approach has its shortcomings in that the electrical heater can only provide heating to the CC, and the required power can be large under certain conditions. An alternative method is to use a TEC, which is capable of providing both heating and cooling to the CC. In this method, one side of the TEC is attached to the CC, and the other side is connected to the evaporator via a thermal strap. Using a bipolar power supply and a control algorithm, a TEC can function as a heater or a cooler, depending on the direction of the current flow. Extensive ground tests of several LHPs have demonstrated that a TEC can provide very tight temperature control for the CC. It also offers several additional advantages: (1) The LHP can operate at temperatures below its natural operating temperature at low heat loads; (2) The required heater power for a TEC is much less than that for an electrical heater; and (3) It enhances the LHP start-up success. Although the concept of using a TEC for LHP temperature control is simple, there are many factors to be considered in its implementation for space applications because the TEC is susceptible to the shear stress and yet has to sustain the dynamic load under the spacecraft launch environment. The added features that help the TEC to withstand the dynamic load will inevitably affect the TEC thermal performance. Some experiences and lessons learned are addressed in this paper.

  11. Exploring Online Game Players' Flow Experiences and Positive Affect

    ERIC Educational Resources Information Center

    Chiang, Yu-Tzu; Lin, Sunny S. J.; Cheng, Chao-Yang; Liu, Eric Zhi-Feng

    2011-01-01

    The authors conducted two studies to explore online game players' flow experiences and positive affect. Our findings indicated that online game are capable of evoking flow experiences and positive affect, and games of violent or nonviolent type may not arouse players' aggression. The players could be placed into four flow conditions: flow,…

  12. Dynamics of Affective Experience and Behavior in Depressed Adolescents

    ERIC Educational Resources Information Center

    Sheeber, Lisa B.; Allen, Nicholas B.; Leve, Craig; Davis, Betsy; Shortt, Joann Wu; Katz, Lynn Fainsilber

    2009-01-01

    Background: Depression is often characterized as a disorder of affect regulation. However, research focused on delineating the key dimensions of affective experience (other than valence) that are abnormal in depressive disorder has been scarce, especially in child and adolescent samples. As definitions of affect regulation center around processes…

  13. 75 FR 16732 - Action Affecting Export Privileges; Aqua-Loop Cooling Towers, Co.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ... facilitating or coordinating the export of approximately 174 rolls of hog hair filter media, part number HH6O..., 2004, Aqua-Loop ordered or financed approximately 174 rolls of hog hair filter media, part number... approximately 185 rolls of hog hair filter media, part number HHB6O 130 and valued at approximately...

  14. Characterizing W-2 SLSF experiment temperature oscillations using computer graphics. [Sodium Loop Safety Facility

    SciTech Connect

    Smith, D.E.

    1983-06-23

    The W-2 SLSF (Sodium Loop Safety Facility) experiment was an instrumented in-reactor test performed to characterize the failure response of full-length, preconditioned LMFBR prototypic fuel pins to slow transient overpower (TOP) conditions. Although the test results were expected to confirm analytical predictions of upper level failure and fuel expulsion, an axial midplane failure was experienced. Extensive post-test analyses were conducted to understand all of the unexpected behavior in the experiment. (1) The initial post-test effort focused on the temperature oscillations recorded by the 54 thermocouples used in the experiment. In order to synthesize the extensive data records and identify patterns of behavior in the data records, a computer-generated film was used to present the temperature data recorded during the experiment.

  15. Size, but not experience, affects the ontogeny of constriction performance in ball pythons (Python regius).

    PubMed

    Penning, David A; Dartez, Schuyler F

    2016-03-01

    Constriction is a prey-immobilization technique used by many snakes and is hypothesized to have been important to the evolution and diversification of snakes. However, very few studies have examined the factors that affect constriction performance. We investigated constriction performance in ball pythons (Python regius) by evaluating how peak constriction pressure is affected by snake size, sex, and experience. In one experiment, we tested the ontogenetic scaling of constriction performance and found that snake diameter was the only significant factor determining peak constriction pressure. The number of loops applied in a coil and its interaction with snake diameter did not significantly affect constriction performance. Constriction performance in ball pythons scaled differently than in other snakes that have been studied, and medium to large ball pythons are capable of exerting significantly higher pressures than those shown to cause circulatory arrest in prey. In a second experiment, we tested the effects of experience on constriction performance in hatchling ball pythons over 10 feeding events. By allowing snakes in one test group to gain constriction experience, and manually feeding snakes under sedation in another test group, we showed that experience did not affect constriction performance. During their final (10th) feedings, all pythons constricted similarly and with sufficiently high pressures to kill prey rapidly. At the end of the 10 feeding trials, snakes that were allowed to constrict were significantly smaller than their non-constricting counterparts.

  16. Micellar lipid composition affects micelle interaction with class B scavenger receptor extracellular loops.

    PubMed

    Goncalves, Aurélie; Gontero, Brigitte; Nowicki, Marion; Margier, Marielle; Masset, Gabriel; Amiot, Marie-Josèphe; Reboul, Emmanuelle

    2015-06-01

    Scavenger receptors (SRs) like cluster determinant 36 (CD36) and SR class B type I (SR-BI) play a debated role in lipid transport across the intestinal brush border membrane. We used surface plasmon resonance to analyze real-time interactions between the extracellular protein loops and various ligands ranging from single lipid molecules to mixed micelles. Micelles mimicking physiological structures were necessary for optimal binding to both the extracellular loop of CD36 (lCD36) and the extracellular loop of SR-BI (lSR-BI). Cholesterol, phospholipid, and fatty acid micellar content significantly modulated micelle binding to and dissociation from the transporters. In particular, high phospholipid micellar concentrations inhibited micelle binding to both receptors (-53.8 and -74.4% binding at 0.32 mM compared with 0.04 mM for lCD36 and lSR-BI, respectively, P < 0.05). The presence of fatty acids was crucial for micelle interactions with both proteins (94.4 and 81.3% binding with oleic acid for lCD36 and lSR-BI, respectively, P < 0.05) and fatty acid type substitution within the micelles was the component that most impacted micelle binding to the transporters. These effects were partly due to subsequent modifications in micellar size and surface electric charge, and could be correlated to micellar vitamin D uptake by Caco-2 cells. Our findings show for the first time that micellar lipid composition and micellar properties are key factors governing micelle interactions with SRs.

  17. Positioning of extracellular loop 1 affects pore gating of the cystic fibrosis transmembrane conductance regulator

    PubMed Central

    Infield, Daniel T.; Cui, Guiying; Kuang, Christopher

    2015-01-01

    The cystic fibrosis (CF) transmembrane conductance regulator (CFTR) is a chloride ion channel, the dysfunction of which directly leads to the life-shortening disease CF. Extracellular loop 1 (ECL1) of CFTR contains several residues involved in stabilizing the open state of the channel; some, including D110, are sites of disease-associated gating mutations. Structures from related proteins suggest that the position of CFTR's extracellular loops may change considerably during gating. To better understand the roles of ECL1 in CFTR function, we utilized functional cysteine cross-linking to determine the effects of modulation of D110C-CFTR and of a double mutant of D110C with K892C in extracellular loop 4 (ECL4). The reducing agent DTT elicited a large potentiation of the macroscopic conductance of D110C/K892C-CFTR, likely due to breakage of a spontaneous disulfide bond between C110 and C892. DTT-reduced D110C/K892C-CFTR was rapidly inhibited by binding cadmium ions with high affinity, suggesting that these residues frequently come in close proximity in actively gating channels. Effects of DTT and cadmium on modulation of pore gating were demonstrated at the single-channel level. Finally, disulfided D110C/K892C-CFTR channels were found to be less sensitive than wild-type or DTT-treated D110C/K892C-CFTR channels to stimulation by IBMX, suggesting an impact of this conformational restriction on channel activation by phosphorylation. The results are best explained in the context of a model of CFTR gating wherein stable channel opening requires correct positioning of functional elements structurally influenced by ECL1. PMID:26684250

  18. Micellar lipid composition affects micelle interaction with class B scavenger receptor extracellular loops

    PubMed Central

    Goncalves, Aurélie; Gontero, Brigitte; Nowicki, Marion; Margier, Marielle; Masset, Gabriel; Amiot, Marie-Josèphe; Reboul, Emmanuelle

    2015-01-01

    Scavenger receptors (SRs) like cluster determinant 36 (CD36) and SR class B type I (SR-BI) play a debated role in lipid transport across the intestinal brush border membrane. We used surface plasmon resonance to analyze real-time interactions between the extracellular protein loops and various ligands ranging from single lipid molecules to mixed micelles. Micelles mimicking physiological structures were necessary for optimal binding to both the extracellular loop of CD36 (lCD36) and the extracellular loop of SR-BI (lSR-BI). Cholesterol, phospholipid, and fatty acid micellar content significantly modulated micelle binding to and dissociation from the transporters. In particular, high phospholipid micellar concentrations inhibited micelle binding to both receptors (−53.8 and −74.4% binding at 0.32 mM compared with 0.04 mM for lCD36 and lSR-BI, respectively, P < 0.05). The presence of fatty acids was crucial for micelle interactions with both proteins (94.4 and 81.3% binding with oleic acid for lCD36 and lSR-BI, respectively, P < 0.05) and fatty acid type substitution within the micelles was the component that most impacted micelle binding to the transporters. These effects were partly due to subsequent modifications in micellar size and surface electric charge, and could be correlated to micellar vitamin D uptake by Caco-2 cells. Our findings show for the first time that micellar lipid composition and micellar properties are key factors governing micelle interactions with SRs. PMID:25833688

  19. A dynamic RNA loop in an IRES affects multiple steps of elongation factor-mediated translation initiation

    PubMed Central

    Ruehle, Marisa D; Zhang, Haibo; Sheridan, Ryan M; Mitra, Somdeb; Chen, Yuanwei; Gonzalez, Ruben L; Cooperman, Barry S; Kieft, Jeffrey S

    2015-01-01

    Internal ribosome entry sites (IRESs) are powerful model systems to understand how the translation machinery can be manipulated by structured RNAs and for exploring inherent features of ribosome function. The intergenic region (IGR) IRESs from the Dicistroviridae family of viruses are structured RNAs that bind directly to the ribosome and initiate translation by co-opting the translation elongation cycle. These IRESs require an RNA pseudoknot that mimics a codon-anticodon interaction and contains a conformationally dynamic loop. We explored the role of this loop and found that both the length and sequence are essential for translation in different types of IGR IRESs and from diverse viruses. We found that loop 3 affects two discrete elongation factor-dependent steps in the IRES initiation mechanism. Our results show how the IRES directs multiple steps after 80S ribosome placement and highlights the often underappreciated significance of discrete conformationally dynamic elements within the context of structured RNAs. DOI: http://dx.doi.org/10.7554/eLife.08146.001 PMID:26523395

  20. SLSF local fault safety experiment P4: summary and conclusions. [Sodium Loop Safety Facility

    SciTech Connect

    Thompson, D.H.; Ragland, W.A.; Holland, J.W.; Dever, D.J.; Braid, T.H.; Baldwin, R.D.; Anderson, T.T.

    1985-01-01

    Sodium Loop Safety Facility (SLSF) experiment P4 in ETR was performed to investigate the consequences of an upper-bound or worse-than-worst case local fault configuration. P4 was intended to bound the consequences of credible subassembly faults by ejecting molten fuel into a 37-pin bundle of full-length Fast Test Reactor (FTR)-type pins and failing fuel with the potential for further cladding and fuel-pin damage. In addition to ejecting a large amount of molten fuel at or near full power, experiment objectives were to evaluate the severity of molten fuel-coolant interactions (MFCIs) and to demonstrate that any resulting blockage could either be tolerated during continued power operation or detected by global monitors in time to prevent significant fuel failure propagation.

  1. Charge and geometry of residues in the loop 2 β hairpin differentially affect agonist and ethanol sensitivity in glycine receptors.

    PubMed

    Perkins, Daya I; Trudell, James R; Asatryan, Liana; Davies, Daryl L; Alkana, Ronald L

    2012-05-01

    Recent studies highlighted the importance of loop 2 of α1 glycine receptors (GlyRs) in the propagation of ligand-binding energy to the channel gate. Mutations that changed polarity at position 52 in the β hairpin of loop 2 significantly affected sensitivity to ethanol. The present study extends the investigation to charged residues. We found that substituting alanine with the negative glutamate at position 52 (A52E) significantly left-shifted the glycine concentration response curve and increased sensitivity to ethanol, whereas the negative aspartate substitution (A52D) significantly right-shifted the glycine EC₅₀ but did not affect ethanol sensitivity. It is noteworthy that the uncharged glutamine at position 52 (A52Q) caused only a small right shift of the glycine EC₅₀ while increasing ethanol sensitivity as much as A52E. In contrast, the shorter uncharged asparagine (A52N) caused the greatest right shift of glycine EC₅₀ and reduced ethanol sensitivity to half of wild type. Collectively, these findings suggest that charge interactions determined by the specific geometry of the amino acid at position 52 (e.g., the 1-Å chain length difference between aspartate and glutamate) play differential roles in receptor sensitivity to agonist and ethanol. We interpret these results in terms of a new homology model of GlyR based on a prokaryotic ion channel and propose that these mutations form salt bridges to residues across the β hairpin (A52E-R59 and A52N-D57). We hypothesize that these electrostatic interactions distort loop 2, thereby changing agonist activation and ethanol modulation. This knowledge will help to define the key physical-chemical parameters that cause the actions of ethanol in GlyRs.

  2. Experiences with the magnetism of conducting loops: Historical instruments, experimental replications, and productive confusions

    NASA Astrophysics Data System (ADS)

    Cavicchi, Elizabeth

    2003-02-01

    This study investigates nineteenth century laboratory work on electromagnetism through historical accounts and experimental replications. Oersted found that when a magnetic needle was placed in varying positions around a conducting wire, its orientation changed: in moving from a spot above the wire to one below, its sense inverted. This behavior was confusing and provocative. Early experimenters such as Johann Schweigger, Johann Poggendorff, and James Cumming engaged it by bending wire into loops. These loops, which increased the magnetic effect on a compass placed within, also provided evidence of their understanding and confusion. Coiling conducting wires around iron magnetized it, but when some wires coiled oppositely from others, the effect diminished. This effect confused contemporaries of Joseph Henry who made electromagnets, and amateurs later in the century who constructed multisection induction coils. I experienced these confusions myself while working with multilayer coils and induction coils that I made to replicate the historical instruments. This study shows how confusion can be a productive element in learning, by engaging learners to ask questions and invent experiments. By providing space for learners' confusions, teachers can support the development of their students' physical understandings.

  3. Comparison of Pressure Drop between Calculation and Experiment for a Two-phase Carbon Dioxide Loop

    NASA Astrophysics Data System (ADS)

    Mo, D.-C.; Xiao, W.-J.; Huang, Z.-C.; Sun, X.-H.; Chen, Y.; Lu, S.-S.; Li, T.-X.; Qi, X.-M.; Wang, Z.-X.; Pauw, A.; Bsibsi, M.; Gargiulo, C.; van Es, J.; He, Z.-H.

    2008-09-01

    Tracker thermal control system (TTCS) is an active-pumped two-phase carbon dioxide cooling loop, which is developed for the Alpha Magnetic Spectrometer tracker front-end electronics. The maintenance-free centrifugal pump is a critical component in the design mainly due to the limited pressure head with small mass flows. Therefore a correct pressure drop is required to predict the pressure drop for dynamic modeling. As the normal operational temperature of the carbon dioxide in the TTCS is from - 15°C to +15°C, which is very close to its critical point, 33°C, and many two-phase pressure drop correlations may not fit well here. In this paper, we attempt to correlate the pressure drops between the calculations and the experiment of the two-phase CO2 loop. The comparison will focus on one evaporator. Here, the Lockhart/Martinelli correlation is recorrelated with different definition C value for CO2 according to the test results. Comparison shows that, the new correlation can fit the test results well.

  4. Evolution of plasma loops in a semi-toroidal pinch experiment

    SciTech Connect

    Mackel, F. Ridder, S.; Tenfelde, J.; Tacke, T.; Soltwisch, H.

    2015-04-15

    The FlareLab experiment is a pulsed-power discharge generating magnetized plasma loops similar to a pinch experiment in a semi-toroidal configuration. After gas breakdown along a circular magnetic guide field, the structure expands in its major radius as the plasma becomes highly conductive and the discharge current rises. Photographs, current and electron density measurements reveal a significant broadening in the lateral direction leading to an increasing departure from radial symmetry of plasma parameters in the cross section. It is shown that the luminosity is related to both high electron density and high current density. Simultaneous measurements of current density and electric field reveal a high parallel resistivity of the plasma leading to fast diffusion across the magnetic field. Indications for anomalous resistivity are found by comparison with the Spitzer formula. As the experiment differs from a z-pinch experiment only by the semi-circular shape of the current path, the observed evolution is unexpected and might be of more fundamental significance.

  5. Experiments of Closed-Loop Flow Control for Laminar Boundary Layers

    NASA Astrophysics Data System (ADS)

    Zhang, Zhenyu

    The Tollmien-Schlichting (T-S) instability is important for the transition process of boundary layer flows. The cancellation of its unstable modes will help delay the occurrence of transition and then turbulence. In this article the T-S instability was attempted to attenuate through an active closed-loop control strategy. The frequency responses of unstable travelling T-S waves were obtained for the implementation of control strategy. Information such as velocity disturbances of both incoming unstable waves and cancelling waves were then fed into the control system. A controller was deliberately designed and tested for the active cancellation of instabilities which were excited by velocity disturbances normal to the wall. The cancellation performance of the control system was validated by experiments in a low turbulence wind tunnel, which proved the functionality of above control strategy upon the active cancellation of boundary layer instabilities.

  6. Language Experience Affects Grouping of Musical Instrument Sounds

    ERIC Educational Resources Information Center

    Bhatara, Anjali; Boll-Avetisyan, Natalie; Agus, Trevor; Höhle, Barbara; Nazzi, Thierry

    2016-01-01

    Language experience clearly affects the perception of speech, but little is known about whether these differences in perception extend to non-speech sounds. In this study, we investigated rhythmic perception of non-linguistic sounds in speakers of French and German using a grouping task, in which complexity (variability in sounds, presence of…

  7. Experiments on chemical looping combustion of coal with a NiO based oxygen carrier

    SciTech Connect

    Shen, Laihong; Wu, Jiahua; Xiao, Jun

    2009-03-15

    A chemical looping combustion process for coal using interconnected fluidized beds with inherent separation of CO{sub 2} is proposed in this paper. The configuration comprises a high velocity fluidized bed as an air reactor, a cyclone, and a spout-fluid bed as a fuel reactor. The high velocity fluidized bed is directly connected to the spout-fluid bed through the cyclone. Gas composition of both fuel reactor and air reactor, carbon content of fly ash in the fuel reactor, carbon conversion efficiency and CO{sub 2} capture efficiency were investigated experimentally. The results showed that coal gasification was the main factor which controlled the contents of CO and CH{sub 4} concentrations in the flue gas of the fuel reactor, carbon conversion efficiency in the process of chemical looping combustion of coal with NiO-based oxygen carrier in the interconnected fluidized beds. Carbon conversion efficiency reached only 92.8% even when the fuel reactor temperature was high up to 970 C. There was an inherent carbon loss in the process of chemical looping combustion of coal in the interconnected fluidized beds. The inherent carbon loss was due to an easy elutriation of fine char particles from the freeboard of the spout-fluid bed, which was inevitable in this kind of fluidized bed reactor. Further improvement of carbon conversion efficiency could be achieved by means of a circulation of fine particles elutriation into the spout-fluid bed or the high velocity fluidized bed. CO{sub 2} capture efficiency reached to its equilibrium of 80% at the fuel reactor temperature of 960 C. The inherent loss of CO{sub 2} capture efficiency was due to bypassing of gases from the fuel reactor to the air reactor, and the product of residual char burnt with air in the air reactor. Further experiments should be performed for a relatively long-time period to investigate the effects of ash and sulfur in coal on the reactivity of nickel-based oxygen carrier in the continuous CLC reactor

  8. Daily affective experiences predict objective sleep outcomes among adolescents.

    PubMed

    Tavernier, Royette; Choo, Sungsub B; Grant, Kathryn; Adam, Emma K

    2016-02-01

    Adolescence is a sensitive period for changes in both sleep and affect. Although past research has assessed the association between affect and sleep among adolescents, few studies have examined both trait (typical) and day-to-day changes in affect, and fewer still have specifically examined negative social evaluative emotions (e.g. embarrassment) in relation to sleep. Both between- and within-person variations in daily affect were examined in relation to four objectively-measured sleep outcomes (sleep hours; sleep latency; sleep efficiency; and length of wake bouts) among adolescents. Participants (N = 77 high-school students; 42.9% female; M = 14.37 years) wore an actiwatch and completed daily-diaries for 3 days. The results of hierarchical linear models (controlling for age, gender, race, ethnicity, parental employment status, income, puberty and caffeine) indicated that negative social evaluative emotions and high-arousal affective experiences generally predicted poor sleep outcomes, whereas low-arousal affective experiences were associated with good sleep outcomes. Specifically, at the person level, adolescents reporting higher negative social evaluative emotions had shorter average sleep hours, and those experiencing higher anxiety–nervousness had longer wake bouts. In addition, individuals experiencing more dysphoria (sad, depressed, lonely) had longer average sleep hours and shorter wake bouts, while those experiencing more calmness had shorter sleep latencies. At the within-person level, individuals had longer sleep latencies following days that they had experienced high-arousal positive affect (e.g. excitement), and had longer wake bouts following days they had experienced more negative social evaluative emotions. The results highlight the detrimental effects of negative social evaluative emotions and high-arousal affective states for adolescent sleep.

  9. Daily Affective Experiences Predict Objective Sleep Outcomes among Adolescents

    PubMed Central

    Tavernier, Royette; Choo, Sungsub B; Grant, Kathryn; Adam, Emma K

    2015-01-01

    Summary Adolescence is a sensitive period for changes in both sleep and affect. Although past research has assessed the association between affect and sleep among adolescents, few studies have examined both trait (typical) and day-to-day changes in affect, and fewer still have specifically examined negative social evaluative emotions (NSEE; e.g., embarrassment) in relation to sleep. We examined both between- and within-person variations in daily affect in relation to four objectively-measured sleep outcomes (sleep hours, sleep latency, sleep efficiency, and length of wake bouts) among adolescents. Participants (N = 77 high school students, 42.9% female; M = 14.37 years) wore an actiwatch and completed daily diaries for 3 days. Results of hierarchical linear models (controlling for age, gender, race, ethnicity, parental employment status, income, puberty, and caffeine) indicated that NSEE and high arousal affective experiences generally predicted poor sleep outcomes, whereas low arousal affective experiences were associated with good sleep outcomes. Specifically, at the person level, adolescents reporting higher NSEE had shorter average sleep hours, and those experiencing higher anxiety-nervousness had longer wake bouts. In addition, individuals experiencing more dysphoria (sad, depressed, lonely) had longer average sleep hours and shorter wake bouts, while those experiencing more calmness had shorter sleep latencies. At the within person level, individuals had longer sleep latencies following days that they had experienced high arousal positive affect (e.g., excitement) and had longer wake bouts following days they had experienced more NSEE. Results highlight the detrimental effects of NSEE and high arousal affective states for adolescent sleep. PMID:26365539

  10. Closed-loop control of renal perfusion pressure in physiological experiments.

    PubMed

    Campos-Delgado, D U; Bonilla, I; Rodríguez-Martínez, M; Sánchez-Briones, M E; Ruiz-Hernández, E

    2013-07-01

    This paper presents the design, experimental modeling, and control of a pump-driven renal perfusion pressure (RPP)-regulatory system to implement precise and relatively fast RPP regulation in rats. The mechatronic system is a simple, low-cost, and reliable device to automate the RPP regulation process based on flow-mediated occlusion. Hence, the regulated signal is the RPP measured in the left femoral artery of the rat, and the manipulated variable is the voltage applied to a dc motor that controls the occlusion of the aorta. The control system is implemented in a PC through the LabView software, and a data acquisition board NI USB-6210. A simple first-order linear system is proposed to approximate the dynamics in the experiment. The parameters of the model are chosen to minimize the error between the predicted and experimental output averaged from eight input/output datasets at different RPP operating conditions. A closed-loop servocontrol system based on a pole-placement PD controller plus dead-zone compensation was proposed for this purpose. First, the feedback structure was validated in simulation by considering parameter uncertainty, and constant and time-varying references. Several experimental tests were also conducted to validate in real time the closed-loop performance for stepwise and fast switching references, and the results show the effectiveness of the proposed automatic system to regulate the RPP in the rat, in a precise, accurate (mean error less than 2 mmHg) and relatively fast mode (10-15 s of response time).

  11. The Impact of Experience on Affective Responses during Action Observation

    PubMed Central

    Kirsch, Louise P.; Snagg, Arielle; Heerey, Erin

    2016-01-01

    Perceiving others in action elicits affective and aesthetic responses in observers. The present study investigates the extent to which these responses relate to an observer’s general experience with observed movements. Facial electromyographic (EMG) responses were recorded in experienced dancers and non-dancers as they watched short videos of movements performed by professional ballet dancers. Responses were recorded from the corrugator supercilii (CS) and zygomaticus major (ZM) muscles, both of which show engagement during the observation of affect-evoking stimuli. In the first part of the experiment, participants passively watched the videos while EMG data were recorded. In the second part, they explicitly rated how much they liked each movement. Results revealed a relationship between explicit affective judgments of the movements and facial muscle activation only among those participants who were experienced with the movements. Specifically, CS activity was higher for disliked movements and ZM activity was higher for liked movements among dancers but not among non-dancers. The relationship between explicit liking ratings and EMG data in experienced observers suggests that facial muscles subtly echo affective judgments even when viewing actions that are not intentionally emotional in nature, thus underscoring the potential of EMG as a method to examine subtle shifts in implicit affective responses during action observation. PMID:27149106

  12. The Impact of Experience on Affective Responses during Action Observation.

    PubMed

    Kirsch, Louise P; Snagg, Arielle; Heerey, Erin; Cross, Emily S

    2016-01-01

    Perceiving others in action elicits affective and aesthetic responses in observers. The present study investigates the extent to which these responses relate to an observer's general experience with observed movements. Facial electromyographic (EMG) responses were recorded in experienced dancers and non-dancers as they watched short videos of movements performed by professional ballet dancers. Responses were recorded from the corrugator supercilii (CS) and zygomaticus major (ZM) muscles, both of which show engagement during the observation of affect-evoking stimuli. In the first part of the experiment, participants passively watched the videos while EMG data were recorded. In the second part, they explicitly rated how much they liked each movement. Results revealed a relationship between explicit affective judgments of the movements and facial muscle activation only among those participants who were experienced with the movements. Specifically, CS activity was higher for disliked movements and ZM activity was higher for liked movements among dancers but not among non-dancers. The relationship between explicit liking ratings and EMG data in experienced observers suggests that facial muscles subtly echo affective judgments even when viewing actions that are not intentionally emotional in nature, thus underscoring the potential of EMG as a method to examine subtle shifts in implicit affective responses during action observation.

  13. Fighting experience affects fruit fly behavior in a mating context

    NASA Astrophysics Data System (ADS)

    Teseo, Serafino; Veerus, Liisa; Mery, Frédéric

    2016-06-01

    In animals, correlations exist among behaviors within individuals, but it is unclear whether experience in a specific functional context can affect behavior across different contexts. Here, we use Drosophila melanogaster to investigate the effects of conflict-induced behavioral modifications on male mating behavior. In D. melanogaster, males fight for territories and experience a strong winner-loser effect, meaning that winners become more likely to win subsequent fights compared to losers, who continue to lose. In our protocol, males were tested for courtship intensity before and after fighting against other males. We show that male motivation to copulate before fights cannot predict the fight outcomes, but that, afterwards, losers mate less than before and less than winner and control males. Contrarily, winners show no differences between pre- and post-fight courtship intensity, and do not differ from control males. This suggests that the physiological modifications resulting from fight outcomes indirectly affect male reproductive behavior.

  14. Fighting experience affects fruit fly behavior in a mating context.

    PubMed

    Teseo, Serafino; Veerus, Liisa; Mery, Frédéric

    2016-06-01

    In animals, correlations exist among behaviors within individuals, but it is unclear whether experience in a specific functional context can affect behavior across different contexts. Here, we use Drosophila melanogaster to investigate the effects of conflict-induced behavioral modifications on male mating behavior. In D. melanogaster, males fight for territories and experience a strong winner-loser effect, meaning that winners become more likely to win subsequent fights compared to losers, who continue to lose. In our protocol, males were tested for courtship intensity before and after fighting against other males. We show that male motivation to copulate before fights cannot predict the fight outcomes, but that, afterwards, losers mate less than before and less than winner and control males. Contrarily, winners show no differences between pre- and post-fight courtship intensity, and do not differ from control males. This suggests that the physiological modifications resulting from fight outcomes indirectly affect male reproductive behavior.

  15. A Moral Experience Feedback Loop: Modeling a System of Moral Self-Cultivation in Everyday Life

    ERIC Educational Resources Information Center

    Sherblom, Stephen A.

    2015-01-01

    This "systems thinking" model illustrates a common feedback loop by which people engage the moral world and continually reshape their moral sensibility. The model highlights seven processes that collectively form this feedback loop: beginning with (1) one's current moral sensibility which shapes processes of (2) perception, (3)…

  16. The impact of sensorimotor experience on affective evaluation of dance

    PubMed Central

    Kirsch, Louise P.; Drommelschmidt, Kim A.; Cross, Emily S.

    2013-01-01

    Past research demonstrates that we are more likely to positively evaluate a stimulus if we have had previous experience with that stimulus. This has been shown for judgment of faces, architecture, artworks and body movements. In contrast, other evidence suggests that this relationship can also work in the inverse direction, at least in the domain of watching dance. Specifically, it has been shown that in certain contexts, people derive greater pleasure from watching unfamiliar movements they would not be able to physically reproduce compared to simpler, familiar actions they could physically reproduce. It remains unknown, however, how different kinds of experience with complex actions, such as dance, might change observers' affective judgments of these movements. Our aim was to clarify the relationship between experience and affective evaluation of whole body movements. In a between-subjects design, participants received either physical dance training with a video game system, visual and auditory experience or auditory experience only. Participants' aesthetic preferences for dance stimuli were measured before and after the training sessions. Results show that participants from the physical training group not only improved their physical performance of the dance sequences, but also reported higher enjoyment and interest in the stimuli after training. This suggests that physically learning particular movements leads to greater enjoyment while observing them. These effects are not simply due to increased familiarity with audio or visual elements of the stimuli, as the other two training groups showed no increase in aesthetic ratings post-training. We suggest these results support an embodied simulation account of aesthetics, and discuss how the present findings contribute to a better understanding of the shaping of preferences by sensorimotor experience. PMID:24027511

  17. Phenylnaphthalene Derivatives as Heat Transfer Fluids for Concentrating Solar Power: Loop Experiments and Final Report

    SciTech Connect

    McFarlane, Joanna; Bell, Jason R; Felde, David K; Joseph III, Robert Anthony; Qualls, A L; Weaver, Samuel P

    2013-02-01

    ORNL and subcontractor Cool Energy completed an investigation of higher-temperature, organic thermal fluids for solar thermal applications. Although static thermal tests showed promising results for 1-phenylnaphthalene, loop testing at temperatures to 450 C showed that the material isomerized at a slow rate. In a loop with a temperature high enough to drive the isomerization, the higher melting point byproducts tended to condense onto cooler surfaces. So, as experienced in loop operation, eventually the internal channels of cooler components such as the waste heat rejection exchanger may become coated or clogged and loop performance will decrease. Thus, pure 1-phenylnaphthalene does not appear to be a fluid that would have a sufficiently long lifetime (years to decades) to be used in a loop at the increased temperatures of interest. Hence a decision was made not to test the ORNL fluid in the loop at Cool Energy Inc. Instead, Cool Energy tested and modeled power conversion from a moderate-temperature solar loop using coupled Stirling engines. Cool Energy analyzed data collected on third and fourth generation SolarHeart Stirling engines operating on a rooftop solar field with a lower temperature (Marlotherm) heat transfer fluid. The operating efficiencies of the Stirling engines were determined at multiple, typical solar conditions, based on data from actual cycle operation. Results highlighted the advantages of inherent thermal energy storage in the power conversion system.

  18. Affect Modulated Startle in Schizophrenia: Subjective Experience Matters

    PubMed Central

    Dominelli, Rachelle M.; Boggs, Jennifer M.; Bolbecker, Amanda R.; O'Donnell, Brian F.; Hetrick, William P.; Brenner, Colleen A.

    2014-01-01

    Data suggests that emotion reactivity as measured by the affect-modulated startle paradigm in those with schizophrenia (SZ) may be similar to healthy controls (HC). However, normative classification of the stimuli may not accurately reflect emotional experience, especially for those with SZ. To examine this possibility, the present study measured the affect-modulated startle response with images classified according to both normative and subjective ratings. Seventeen HC and 17 SZ completed an image viewing task during which startle probes were presented, followed by subjective valence and arousal ratings. Both groups exhibited inhibited startle responses to positive images, intermediate startle amplitudes to neutral images, and potentiated startle amplitudes to negative images. SZ rated the positive images as less positive than HC. When images were reclassified based on subjective valence ratings, both groups’ startle magnitudes increased in response to subjectively rated positive images and decreased to subjectively rated neutral images. The number of trials classified into each valence condition suggested a tendency for SZ to classify neutral images as negative more often than HC. Overall, these findings suggest that affective stimuli modulate the startle response in HC and SZ in similar ways, but subjective emotional experience may differ in those with schizophrenia. PMID:25107317

  19. The grape berry-specific basic helix-loop-helix transcription factor VvCEB1 affects cell size.

    PubMed

    Nicolas, Philippe; Lecourieux, David; Gomès, Eric; Delrot, Serge; Lecourieux, Fatma

    2013-02-01

    The development of fleshy fruits involves complex physiological and biochemical changes. After fertilization, fruit growth usually begins with cell division, continues with both cell division and expansion, allowing fruit set to occur, and ends with cell expansion only. In spite of the economical importance of grapevine, the molecular mechanisms controlling berry growth are not fully understood. The present work identified and characterized Vitis vinifera cell elongation bHLH protein (VvCEB1), a basic helix-loop-helix (bHLH) transcription factor controlling cell expansion in grape. VvCEB1 was expressed specifically in berry-expanding tissues with a maximum around veraison. The study of VvCEB1 promoter activity in tomato confirmed its specific fruit expression during the expansion phase. Overexpression of VvCEB1 in grape embryos showed that this protein stimulates cell expansion and affects the expression of genes involved in cell expansion, including genes of auxin metabolism and signalling. Taken together, these data show that VvCEB1 is a fruit-specific bHLH transcription factor involved in grape berry development.

  20. Effects of mediated social touch on affective experiences and trust

    PubMed Central

    Erk, Stefanie M.; Van Erp, Jan B.F.

    2015-01-01

    This study investigated whether communication via mediated hand pressure during a remotely shared experience (watching an amusing video) can (1) enhance recovery from sadness, (2) enhance the affective quality of the experience, and (3) increase trust towards the communication partner. Thereto participants first watched a sad movie clip to elicit sadness, followed by a funny one to stimulate recovery from sadness. While watching the funny clip they signaled a hypothetical fellow participant every time they felt amused. In the experimental condition the participants responded by pressing a hand-held two-way mediated touch device (a Frebble), which also provided haptic feedback via simulated hand squeezes. In the control condition they responded by pressing a button and they received abstract visual feedback. Objective (heart rate, galvanic skin conductance, number and duration of joystick or Frebble presses) and subjective (questionnaires) data were collected to assess the emotional reactions of the participants. The subjective measurements confirmed that the sad movie successfully induced sadness while the funny movie indeed evoked more positive feelings. Although their ranking agreed with the subjective measurements, the physiological measurements confirmed this conclusion only for the funny movie. The results show that recovery from movie induced sadness, the affective experience of the amusing movie, and trust towards the communication partner did not differ between both experimental conditions. Hence, feedback via mediated hand touching did not enhance either of these factors compared to visual feedback. Further analysis of the data showed that participants scoring low on Extraversion (i.e., persons that are more introvert) or low on Touch Receptivity (i.e., persons who do not like to be touched by others) felt better understood by their communication partner when receiving mediated touch feedback instead of visual feedback, while the opposite was found for

  1. Effects of mediated social touch on affective experiences and trust.

    PubMed

    Erk, Stefanie M; Toet, Alexander; Van Erp, Jan B F

    2015-01-01

    This study investigated whether communication via mediated hand pressure during a remotely shared experience (watching an amusing video) can (1) enhance recovery from sadness, (2) enhance the affective quality of the experience, and (3) increase trust towards the communication partner. Thereto participants first watched a sad movie clip to elicit sadness, followed by a funny one to stimulate recovery from sadness. While watching the funny clip they signaled a hypothetical fellow participant every time they felt amused. In the experimental condition the participants responded by pressing a hand-held two-way mediated touch device (a Frebble), which also provided haptic feedback via simulated hand squeezes. In the control condition they responded by pressing a button and they received abstract visual feedback. Objective (heart rate, galvanic skin conductance, number and duration of joystick or Frebble presses) and subjective (questionnaires) data were collected to assess the emotional reactions of the participants. The subjective measurements confirmed that the sad movie successfully induced sadness while the funny movie indeed evoked more positive feelings. Although their ranking agreed with the subjective measurements, the physiological measurements confirmed this conclusion only for the funny movie. The results show that recovery from movie induced sadness, the affective experience of the amusing movie, and trust towards the communication partner did not differ between both experimental conditions. Hence, feedback via mediated hand touching did not enhance either of these factors compared to visual feedback. Further analysis of the data showed that participants scoring low on Extraversion (i.e., persons that are more introvert) or low on Touch Receptivity (i.e., persons who do not like to be touched by others) felt better understood by their communication partner when receiving mediated touch feedback instead of visual feedback, while the opposite was found for

  2. Acceptance of cravings: how smoking cessation experiences affect craving beliefs.

    PubMed

    Nosen, Elizabeth; Woody, Sheila R

    2014-08-01

    Metacognitive models theorize that more negative appraisals of craving-related thoughts and feelings, and greater efforts to avoid or control these experiences, exacerbate suffering and increase chances the person will use substances to obtain relief. Thus far, little research has examined how attempts to quit smoking influence the way people perceive and respond to cravings. As part of a larger study, 176 adult smokers interested in quitting participated in two lab sessions, four days apart. Half the sample began a quit attempt the day after the first session; craving-related beliefs, metacognitive strategies, and negative affect were assessed at the second session. Participants who failed to abstain from smoking more strongly endorsed appraisals of craving-related thoughts as negative and personally relevant. Negative appraisals correlated strongly with distress and withdrawal symptoms. Attempting to quit smoking increased use of distraction, thought suppression and re-appraisal techniques, with no difference between successful and unsuccessful quitters. Negative beliefs about cravings and rumination predicted less change in smoking one month later. Results suggest that smoking cessation outcomes and metacognitive beliefs likely have a bidirectional relationship that is strongly related to negative affect. Greater consideration of the impact of cessation experiences on mood and craving beliefs is warranted.

  3. TREAT MK III Loop Thermoelastoplastic Stress Analysis for the L03 Experiment

    SciTech Connect

    Kennedy, James M.

    1981-03-01

    The STRAW code was used to analyze the static response of a TREAT MK III loop subjected to thermal and mechanical loadings arising from an accident situation for the purpose of determining the defiections and stresses. This analysis provides safety support for the L03 reactivity accident study. The analysis was subdivided into two tasks: (1) an analysis of a flow blockage accident (Cases A and B), where all the energy is assumed deposited in the test leg, resulting in a temperature increase from 530°F to 1720°F, with a small internal pressure throughout the loop and (2) an analysis of a second flow blockage accident (Cases C and D), where again, all the energy is assumed to he deposited in the test leg, resulting in a temperature rise from 530°F to 1845°F, with a small internal pressure throughout the loop. The purpose of these two tasks was to determine if loop failure can occur with the thermal differential across the pump and test legs. Also of interest is whether an undesirable amount of loop lateral deflection will be caused by the thermal differential. A two dimensional analysis of the TREAT MK III loop was performed. The analysis accounted for material nonlinearities, both as a function of temperature and stress, and geometric nonlinearities arising from large deflections. Straight beam elements with annular cross sections were used to model the loop. The analyses show that the maximum strains are less than 21% of their failure strains for all subcases of Cases A and B. For all subcases of cases C and D, the maximum strains are less than 53% of their failure strains. The failure strain is 27.9% for the material at 530°F, 38.1% at 1720°F and 17.8% at 1845°F. Large lateral deflections are observed when the loop is not constrained except at its clamped support--as much as 8.6 inches. However, by accounting for the constraint of the concrete biological shield, the maximum lateral deflection was reduced to less than 0.05 inches at the points of concern.

  4. Preliminary terrestrial based experiments on gravity-affected crystal growth

    NASA Technical Reports Server (NTRS)

    Johnston, M. H.

    1970-01-01

    Tin was melted in a heating assembly secured to the arm of a centrifuge. The furnace was allowed to pivot and reach its equilibrium angle of swing for the gravity force being experienced. The crucible was cooled during rotation to allow the growth of single crystals. The crystals were etched for the purpose of observing the growth striations. Slices were removed from some of the crystals to permit observation of the striations in the interior. Visual analyses were made with a scanning electron microscope. Preliminary conclusions relating the appearance of the striations to gravity forces and the affected growth mechanisms are presented. Further experiments that will verify these conclusions and determine other gravity effects are proposed.

  5. Factors affecting individual injury experience among petroleum drilling workers.

    PubMed

    Mueller, B A; Mohr, D L; Rice, J C; Clemmer, D I

    1987-02-01

    To identify factors affecting the number of injuries experienced by petroleum drilling workers, we carried out a 44-month incidence density study on a cohort employed in January 1979 on mobile drilling units in the Gulf of Mexico. To control for job-related hazards, we computed a standardized ratio of observed to expected injuries for each worker based on his job history. The effect of personal and work history factors was then examined using analysis of variance. Age, rate of job changes, and rate of rig transfers had independent effects on injury rates. Length of service had little effect when age was controlled. The findings suggest that younger workers under stress such as job change may be more susceptible to injury than older workers, regardless of job. If so, targeted changes in procedures and environment which protect workers of all ages are important alternatives to reliance on supervision and experience in injury reduction.

  6. How do musical tonality and experience affect visual working memory?

    PubMed

    Yang, Hua; Lu, Jing; Gong, Diankun; Yao, Dezhong

    2016-01-20

    The influence of music on the human brain has continued to attract increasing attention from neuroscientists and musicologists. Currently, tonal music is widely present in people's daily lives; however, atonal music has gradually become an important part of modern music. In this study, we conducted two experiments: the first one tested for differences in perception of distractibility between tonal music and atonal music. The second experiment tested how tonal music and atonal music affect visual working memory by comparing musicians and nonmusicians who were placed in contexts with background tonal music, atonal music, and silence. They were instructed to complete a delay matching memory task. The results show that musicians and nonmusicians have different evaluations of the distractibility of tonal music and atonal music, possibly indicating that long-term training may lead to a higher auditory perception threshold among musicians. For the working memory task, musicians reacted faster than nonmusicians in all background music cases, and musicians took more time to respond in the tonal background music condition than in the other conditions. Therefore, our results suggest that for a visual memory task, background tonal music may occupy more cognitive resources than atonal music or silence for musicians, leaving few resources left for the memory task. Moreover, the musicians outperformed the nonmusicians because of the higher sensitivity to background music, which also needs a further longitudinal study to be confirmed.

  7. Experiences of Looping for Students with Learning Disabilities: A Phenomenological Case Study

    ERIC Educational Resources Information Center

    Brown, Laura C.

    2011-01-01

    The problem is the academic, social, and emotional needs of students with learning disabilities are not being met within the general classroom. Looping, the practice of a teacher staying with the same group of students for two or more years, has been suggested as an educational approach designed to meet the needs of students with disabilities. The…

  8. Cross-Species Affective Neuroscience Decoding of the Primal Affective Experiences of Humans and Related Animals

    PubMed Central

    Panksepp, Jaak

    2011-01-01

    Background The issue of whether other animals have internally felt experiences has vexed animal behavioral science since its inception. Although most investigators remain agnostic on such contentious issues, there is now abundant experimental evidence indicating that all mammals have negatively and positively-valenced emotional networks concentrated in homologous brain regions that mediate affective experiences when animals are emotionally aroused. That is what the neuroscientific evidence indicates. Principal Findings The relevant lines of evidence are as follows: 1) It is easy to elicit powerful unconditioned emotional responses using localized electrical stimulation of the brain (ESB); these effects are concentrated in ancient subcortical brain regions. Seven types of emotional arousals have been described; using a special capitalized nomenclature for such primary process emotional systems, they are SEEKING, RAGE, FEAR, LUST, CARE, PANIC/GRIEF and PLAY. 2) These brain circuits are situated in homologous subcortical brain regions in all vertebrates tested. Thus, if one activates FEAR arousal circuits in rats, cats or primates, all exhibit similar fear responses. 3) All primary-process emotional-instinctual urges, even ones as complex as social PLAY, remain intact after radical neo-decortication early in life; thus, the neocortex is not essential for the generation of primary-process emotionality. 4) Using diverse measures, one can demonstrate that animals like and dislike ESB of brain regions that evoke unconditioned instinctual emotional behaviors: Such ESBs can serve as ‘rewards’ and ‘punishments’ in diverse approach and escape/avoidance learning tasks. 5) Comparable ESB of human brains yield comparable affective experiences. Thus, robust evidence indicates that raw primary-process (i.e., instinctual, unconditioned) emotional behaviors and feelings emanate from homologous brain functions in all mammals (see Appendix S1), which are regulated by higher

  9. Investigations on loop antenna excited whistler waves in a cylindrical plasma based on laboratory experiments and simulations

    NASA Astrophysics Data System (ADS)

    Pfannmöller, J. P.; Lechte, C.; Grulke, O.; Klinger, T.

    2012-10-01

    Experimental investigations and simulations of loop antenna excited whistler waves in a cylindrical low temperature plasma are presented. Experiments are performed in the VINETA [Franck et al., Plasma Sources Sci. Technol. 14, 226 (2005)] device and simulations are generated using IPF-FD3D [C. Lechte, IEEE Trans. Plasma Sci. 37, 1099 (2009)], an implementation of the Yee-algorithm. A good agreement of the experiment and the simulation is found. The simulation is used to predict the spatial structure of the wave, the dominant source of the electric field, the relative contribution of electron, and displacement current as well as parallel and perpendicular currents to the magnetic field of the wave.

  10. Investigations on loop antenna excited whistler waves in a cylindrical plasma based on laboratory experiments and simulations

    SciTech Connect

    Pfannmoeller, J. P.; Lechte, C.; Grulke, O.; Klinger, T.

    2012-10-15

    Experimental investigations and simulations of loop antenna excited whistler waves in a cylindrical low temperature plasma are presented. Experiments are performed in the VINETA [Franck et al., Plasma Sources Sci. Technol. 14, 226 (2005)] device and simulations are generated using IPF-FD3D [C. Lechte, IEEE Trans. Plasma Sci. 37, 1099 (2009)], an implementation of the Yee-algorithm. A good agreement of the experiment and the simulation is found. The simulation is used to predict the spatial structure of the wave, the dominant source of the electric field, the relative contribution of electron, and displacement current as well as parallel and perpendicular currents to the magnetic field of the wave.

  11. In-Space technology experiments program. A high efficiency thermal interface (using condensation heat transfer) between a 2-phase fluid loop and heatpipe radiator: Experiment definition phase

    NASA Technical Reports Server (NTRS)

    Pohner, John A.; Dempsey, Brian P.; Herold, Leroy M.

    1990-01-01

    Space Station elements and advanced military spacecraft will require rejection of tens of kilowatts of waste heat. Large space radiators and two-phase heat transport loops will be required. To minimize radiator size and weight, it is critical to minimize the temperature drop between the heat source and sink. Under an Air Force contract, a unique, high-performance heat exchanger is developed for coupling the radiator to the transport loop. Since fluid flow through the heat exchanger is driven by capillary forces which are easily dominated by gravity forces in ground testing, it is necessary to perform microgravity thermal testing to verify the design. This contract consists of an experiment definition phase leading to a preliminary design and cost estimate for a shuttle-based flight experiment of this heat exchanger design. This program will utilize modified hardware from a ground test program for the heat exchanger.

  12. Switch-Loop Flexibility Affects Transport of Large Drugs by the Promiscuous AcrB Multidrug Efflux Transporter

    PubMed Central

    Cha, Hi-jea; Müller, Reinke T.

    2014-01-01

    Multidrug efflux transporters recognize a variety of structurally unrelated compounds for which the molecular basis is poorly understood. For the resistance nodulation and cell division (RND) inner membrane component AcrB of the AcrAB-TolC multidrug efflux system from Escherichia coli, drug binding occurs at the access and deep binding pockets. These two binding areas are separated by an 11-amino-acid-residue-containing switch loop whose conformational flexibility is speculated to be essential for drug binding and transport. A G616N substitution in the switch loop has a distinct and local effect on the orientation of the loop and on the ability to transport larger drugs. Here, we report a distinct phenotypical pattern of drug recognition and transport for the G616N variant, indicating that drug substrates with minimal projection areas of >70 Å2 are less well transported than other substrates. PMID:24914123

  13. Closed-loop experiment of resonator integrated optic gyro with triangular wave phase modulation

    NASA Astrophysics Data System (ADS)

    Tang, Yichuang; Liu, Huilan; Zhi, Yinzhou; Feng, Lishuang; Wang, Junjie

    2014-10-01

    A closed-loop resonator integrated optic gyro (RIOG) scheme based on triangular wave phase modulation is proposed. Only one integrated optic modulator (IOM) is employed. Triangular wave is applied on the IOM to modulate the passing light wave, and the feedback serrodyne wave is superimposed upon the triangular wave to compensate the resonant frequency-difference. The experimental setup is established and the related measurements are performed. The results show that the proposed scheme can realize the closed-loop RIOG employing an IOM, which has the advantage of miniature size. A bias stability of 0.39 deg/s (10 s integration time) over 1 hour is achieved. Moreover, good linearity and large dynamic range are also experimental demonstrated.

  14. Specific Previous Experience Affects Perception of Harmony and Meter

    ERIC Educational Resources Information Center

    Creel, Sarah C.

    2011-01-01

    Prior knowledge shapes our experiences, but which prior knowledge shapes which experiences? This question is addressed in the domain of music perception. Three experiments were used to determine whether listeners activate specific musical memories during music listening. Each experiment provided listeners with one of two musical contexts that was…

  15. Open and closed-loop experiments to identify the separated flow dynamics of a thick turbulent boundary layer

    NASA Astrophysics Data System (ADS)

    Shaqarin, T.; Braud, C.; Coudert, S.; Stanislas, M.

    2013-02-01

    Open and closed-loop flow control experiments were performed on the transient attachment and separation mechanisms of a thick turbulent boundary layer (TBL). Without actuation, the TBL is subjected to an adverse pressure gradient and separates downstream of a sharp variation in the wall geometry. Departing from a given geometry and steady operations of vortex generator actuators, the control objective was to attach the flow in the separated region with a minimum of injected fluid using adaptation of the closed-loop control. The large scale of the facility (i.e., δ = 20 cm upstream of separation) induces large time scales and large Reynolds numbers of the flow to be controlled. It is found to consequently induce large time scales of the separation/attachment mechanisms, making the dynamic closed-loop implementation easier. Open-loop tests were first performed to extract the adequate input/output variables for closed-loop implementations. The chosen input variable was the Duty Cycle, DC, which enables sending of a control action at least 10 times faster than the time scales of the attachment/separation process. The chosen output variable was the voltage signal from a hot-film probe located on the flap which characterizes the degree of separation. In open loop, both the large scale (i.e., large time scales) of the present facility (Carlier and Stanislas in J Fluid Mech 535(36):143-188, 2005) and the well-defined excitation (Braud and Dyment in Phys Fluids 24:047102, 2012) help to extract the different time scales involved and to identify the whole system (actuators, baseline flow and sensor). Three Reynolds numbers based on the momentum thickness of the boundary layer near the actuators and upstream of separation were investigated ( Re θ = 7,500, 10,500 and 12,600) through variation of the free-stream velocity ( U ∞ = 5, 8, 10 m/s). These three systems were found to behave like first-order linear systems, with coefficients that need to be adapted depending on the

  16. Experiment to Study Alfv'en Wave Propagation in Plasma Loops

    NASA Astrophysics Data System (ADS)

    Kendall, Mark; Bellan, Paul

    2009-11-01

    Solar coronal loops are simulated in the laboratory using pulsed power techniques [1]. We are now developing a method to excite propagating Alfv'en wave modes by superposing a current pulse of roughly 10kA and width 100ns upon the ˜50kA, 10 microsecond main discharge current that flows along the ˜10cm long, 1cm diameter arched flux tube. To achieve this short 100ns pulsed timescale at such high power, a magnetic pulse compression technique based on saturable reactors will be employed. A low power prototype has been successfully tested, and design and construction of a full-power device is underway. Upon completion, the fast current pulse device will be used to investigate interactions between the Alfv'en waves and the larger-scale loop evolution. Particular attention will be paid to wave propagation including dispersion and reflection, as well as dissipation mechanisms and possible energetic particle generation.[4pt] [1] J. F. Hansen, S. K. P. Tripathi, P. M. Bellan, ``Co- and Counter-helicity Interaction Between Two Adjacent Laboratory Prominences,'' Phys. Plasmas, vol. 11, issue 6, p. 3177 (2004)

  17. Inverted hysteresis loops in magnetically coupled bilayers with uniaxial competing anisotropies: Theory and experiments

    NASA Astrophysics Data System (ADS)

    Valvidares, S. M.; Álvarez-Prado, L. M.; Martín, J. I.; Alameda, J. M.

    2001-10-01

    The magnetization reversal processes in magnetic bilayers with individual uniaxial anisotropies have been studied, both theoretically and experimentally, to analyze the possible existence of inverted hysteresis loops, that is, with negative remanent magnetization (Mr). Kerr effect measurements in amorphous YCo2/YCo2 bilayers and alternating gradient magnetometry in polycrystalline FeNi/FeNi samples reveal that Mr<0 can be observed for certain directions of the applied magnetic field in the sample plane. This property has also been found in CoNbZr films annealed under an applied field. Our theoretical approach shows that the behavior of these magnetic heterogeneous systems with two coupled uniaxial anisotropies can be understood in terms of two competing effective anisotropies, one biaxial (with Kbiax) and one uniaxial (with Kuniax). In particular, a phase diagram has been deduced for the conditions on Kbiax and Kuniax that can produce negative remanence. This description indicates that, under those anisotropy conditions, inverted hysteresis loops can be observed for an applied field close to the hard axis of the effective uniaxial anisotropy, when magnetization reversal is driven by rotations and not by domain nucleation and wall movement. To consider the real situation in a YCo2/YCo2 bilayer sample, the predictions of this phenomenological model have been further improved by micromagnetic calculations, which are in very good agreement with the magneto-optical measurements.

  18. How training and experience affect the benefits of autonomy in a dirty-bomb experiment

    SciTech Connect

    David J. Bruemmer; Curtis W. Nielsen; David I. Gertman

    2008-03-01

    A dirty-bomb experiment conducted at the INL is used to evaluate the effectiveness and suitability of three different modes of robot control. The experiment uses three distinct user groups to understand how participants’ background and training affect the way in which they use and benefit from autonomy. The results show that the target mode, which involves automated mapping and plume tracing together with a point and click tasking tool, provides the best performance for each group. This is true for objective performance such as source detection and localization accuracy as well as subjective measures such as perceived workload, frustration and preference. The best overall performance is achieved by the Explosive Ordinance Disposal group which has experience in both robot teleoperation and dirty bomb response. The user group that benefits least from autonomy is the Nuclear Engineers that have no experience with either robot operation or dirty bomb response. The group that benefits most from autonomy is the Weapons of Mass Destruction Civil Response Team that has extensive experience related to the task, but no robot training.

  19. How differentiated do children experience affect? An investigation of the within- and between-person structure of children's affect.

    PubMed

    Leonhardt, Anja; Könen, Tanja; Dirk, Judith; Schmiedek, Florian

    2016-05-01

    Research on the structure of children's affect is limited. It is possible that children's perception of their own affect might be less differentiated than that of adults. Support for the 2-factor model of positive and negative affect and the pleasure-arousal model suggests that children in middle childhood can distinguish positive and negative affect as well as valence and arousal. Whether children are able to differentiate further aspects of affect, as proposed by the 3-dimensional model of affect (good-bad mood, alertness-tiredness, calmness-tension), is an unresolved issue. The aim of our study was the comparison of these 3 affect models to establish how differentiated children experience their affect and which model best describes affect in children. We examined affect structures on the between- and within-person level, acknowledging that affect varies across time and that no valid interpretation of either level is feasible if both are confounded. For this purpose, 214 children (age 8-11 years) answered affect items once a day for 5 consecutive days on smartphones. We tested all affect models by means of 2-level confirmatory factor analysis. Although all affect models had an acceptable fit, the 3-dimensional model best described affect in children on both the within- and between-person level. Thus, children in middle childhood can already describe affect in a differentiated way. Also, affect structures were similar on the within- and between-person level. We conclude that in order to acquire a thorough picture of children's affect, measures for children should include items of all 3 affect dimensions. (PsycINFO Database Record

  20. Closing the loop on improvement: Packaging experience in the Software Engineering Laboratory

    NASA Technical Reports Server (NTRS)

    Waligora, Sharon R.; Landis, Linda C.; Doland, Jerry T.

    1994-01-01

    As part of its award-winning software process improvement program, the Software Engineering Laboratory (SEL) has developed an effective method for packaging organizational best practices based on real project experience into useful handbooks and training courses. This paper shares the SEL's experience over the past 12 years creating and updating software process handbooks and training courses. It provides cost models and guidelines for successful experience packaging derived from SEL experience.

  1. The Loop Current Dynamics Experiment (2009-2011) in the Gulf of Mexico

    NASA Astrophysics Data System (ADS)

    Lugo-Fernández, Alexis

    2016-12-01

    The Environmental Studies Program of the US Department of the Interior's Bureau of Ocean Energy Management (BOEM) has sponsored oceanographic research in the Gulf of Mexico for over 40 years. Since 1998, BOEM and its predecessor agencies funded several oceanographic studies on the Gulf's continental slope and beyond. These investigations were aimed at discovering and understanding the physical process driving the circulation and improving numerical models' forecasting skills. One common finding in many of those studies was the ubiquitous influence that the Loop Current (LC) and its associated eddies have on the Gulf's circulation. The LC dominance of the upper layer circulation has been well established by previous studies. Many of these studies suggested that the LC is a source of deep energy below the main thermocline. Yet, despite its acknowledged importance to the Gulf circulation, there had been few observational studies of the LC itself particularly in the main eddy shedding regime.

  2. Affective Beliefs Influence the Experience of Eating Meat.

    PubMed

    Anderson, Eric C; Barrett, Lisa Feldman

    2016-01-01

    People believe they experience the world objectively, but research continually demonstrates that beliefs influence perception. Emerging research indicates that beliefs influence the experience of eating. In three studies, we test whether beliefs about how animals are raised can influence the experience of eating meat. Samples of meat were paired with descriptions of animals raised on factory farms or raised on humane farms. Importantly, the meat samples in both conditions were identical. However, participants experienced the samples differently: meat paired with factory farm descriptions looked, smelled, and tasted less pleasant. Even basic properties of flavor were influenced: factory farmed samples tasted more salty and greasy. Finally, actual behavior was influenced: participants consumed less when samples were paired with factory farm descriptions. These findings demonstrate that the experience of eating is not determined solely by physical properties of stimuli-beliefs also shape experience.

  3. Affective Beliefs Influence the Experience of Eating Meat

    PubMed Central

    Anderson, Eric C.; Barrett, Lisa Feldman

    2016-01-01

    People believe they experience the world objectively, but research continually demonstrates that beliefs influence perception. Emerging research indicates that beliefs influence the experience of eating. In three studies, we test whether beliefs about how animals are raised can influence the experience of eating meat. Samples of meat were paired with descriptions of animals raised on factory farms or raised on humane farms. Importantly, the meat samples in both conditions were identical. However, participants experienced the samples differently: meat paired with factory farm descriptions looked, smelled, and tasted less pleasant. Even basic properties of flavor were influenced: factory farmed samples tasted more salty and greasy. Finally, actual behavior was influenced: participants consumed less when samples were paired with factory farm descriptions. These findings demonstrate that the experience of eating is not determined solely by physical properties of stimuli—beliefs also shape experience. PMID:27556643

  4. Regulative Loops, Step Loops and Task Loops

    ERIC Educational Resources Information Center

    VanLehn, Kurt

    2016-01-01

    This commentary suggests a generalization of the conception of the behavior of tutoring systems, which the target article characterized as having an outer loop that was executed once per task and an inner loop that was executed once per step of the task. A more general conception sees these two loops as instances of regulative loops, which…

  5. Specific previous experience affects perception of harmony and meter.

    PubMed

    Creel, Sarah C

    2011-10-01

    Prior knowledge shapes our experiences, but which prior knowledge shapes which experiences? This question is addressed in the domain of music perception. Three experiments were used to determine whether listeners activate specific musical memories during music listening. Each experiment provided listeners with one of two musical contexts that was presented simultaneously with a melody. After a listener was familiarized with melodies embedded in contexts, the listener heard melodies in isolation and judged the fit of a final harmonic or metrical probe event. The probe event matched either the familiar (but absent) context or an unfamiliar context. For both harmonic (Experiments 1 and 3) and metrical (Experiment 2) information, exposure to context shifted listeners' preferences toward a probe matching the context that they had been familiarized with. This suggests that listeners rapidly form specific musical memories without explicit instruction, which are then activated during music listening. These data pose an interesting challenge for models of music perception which implicitly assume that the listener's knowledge base is predominantly schematic or abstract.

  6. Picosecond lasing in ytterbium fibre laser with nonlinear optical loop mirror: experiment and numerical simulation

    SciTech Connect

    Borodkin, A A; Khudyakov, D V; Vartapetov, S K

    2015-02-28

    The operation regimes of a pulsed all-normal-dispersion polarisation-maintaining fibre laser with a nonlinear optical loop mirror are studied. The use of polarisation-maintaining fibres ensures polarisation and temperature stability of output radiation. The lasing and instability thresholds of the pulsed laser are determined experimentally. A spectral filter placed in the cavity makes it possible to change the centre wavelength of laser radiation within the range 1.02 – 1.05 μm with a spectral full width at half maximum of 2 nm. The average output power is 7 mW, which corresponds to a pulse energy of 0.8 nJ. The autocorrelation function width of the output pulse is 50 ps. The minimum pulse duration achieved after compression by an external pair of diffraction gratings is 1.8 ps. The dynamics of the temporal and spectral parameters of laser pulses is studied using mathematical simulation based on numerical solution of the nonlinear Schrödinger equation. The simulation results coincide with experimental data with a high accuracy. (lasers)

  7. Aesthetic and Affective Experiences in Coffee Shops: A Deweyan Engagement with Ordinary Affects in Ordinary Spaces

    ERIC Educational Resources Information Center

    Nautiyal, Jaishikha

    2016-01-01

    Can everyday spaces, such as coffee shops bustling with rapid activity, promise an aesthetic experience that remains untapped and undertheorized? If so, what kinds of communicative habits make the coffee shop experience aesthetically wholesome? To this end, I engage and extend American pragmatist John Dewey's mission of recovering aesthetic…

  8. Soldier/Hardware-in-the-loop Simulation-based Combat Vehicle Duty Cycle Measurement: Duty Cycle Experiment 2

    DTIC Science & Technology

    2007-01-24

    DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. Soldier/Hardware-in-the-loop Simulation -based Combat Vehicle...dcscorp.com Keywords: Motion base simulator , hybrid electric power system, man-in-the-loop, hardware-in-the-loop, long haul. ABSTRACT: This...paper describes a human-in-the-loop motion-based simulator interfaced to hybrid-electric power system hardware both of which were used to measure the

  9. Prior task experience affects temporal prediction and estimation

    PubMed Central

    Tobin, Simon; Grondin, Simon

    2015-01-01

    It has been shown that prior experience with a task improves temporal prediction, even when the amount of prior experience with the task is often limited. The present study targeted the role of extensive training on temporal prediction. Expert and intermediate runners had to predict the time of a 5 km running competition. Furthermore, after the race’s completion, participants had to estimate their running time so that it could be compared with the predicted time. Results show that expert runners were more accurate than intermediate runners for both predicting and estimating their running time. Furthermore, only expert runners had an estimation that was more accurate than their initial prediction. The results confirm the role of prior task experience in both temporal prediction and estimation. PMID:26217261

  10. Prior task experience affects temporal prediction and estimation.

    PubMed

    Tobin, Simon; Grondin, Simon

    2015-01-01

    It has been shown that prior experience with a task improves temporal prediction, even when the amount of prior experience with the task is often limited. The present study targeted the role of extensive training on temporal prediction. Expert and intermediate runners had to predict the time of a 5 km running competition. Furthermore, after the race's completion, participants had to estimate their running time so that it could be compared with the predicted time. Results show that expert runners were more accurate than intermediate runners for both predicting and estimating their running time. Furthermore, only expert runners had an estimation that was more accurate than their initial prediction. The results confirm the role of prior task experience in both temporal prediction and estimation.

  11. Does Early Research Experience Affect Subsequent Career Choice?

    ERIC Educational Resources Information Center

    Pechmann, Connie A.; Pichert, James W.

    The Vanderbilt Summer Research Program in diabetes, which was designed to interest medical students in research careers and diabetes care, was evaluated. The program provides stipends to 20 sophomore and junior medical students for 12 weeks of preceptor-supervised laboratory research work, clinical experience, and classroom instruction. The…

  12. Starting Smart: How Early Experiences Affect Brain Development. Second Edition.

    ERIC Educational Resources Information Center

    Hawley, Theresa

    Based on recent research, it is now believed that brain growth is highly dependent upon children's early experiences. Neurons allow communication and coordinated functioning among various brain areas. Brain development after birth consists of an ongoing process of wiring and rewiring the connections among neurons. The forming and breaking of…

  13. Bridging the Cognitive-Affective Gaps: Teaching Chemistry while Advancing Affective Objectives. The Singapore Curricular Experience

    ERIC Educational Resources Information Center

    Tan, Kok Siang; Goh, Ngoh Khang; Chia, Lian Sai

    2006-01-01

    Chemistry teachers face constraints when trying to integrate cognitive and affective objectives, and hence thoughtful lesson planning is required to achieve the goal. Chemistry teachers can educate students to be knowledgeable about chemical concepts, processes and the benefits of responsible practice by the chemical industry, while being aware,…

  14. Early Social Experience Affects the Development of Eye Gaze Processing

    PubMed Central

    Senju, Atsushi; Vernetti, Angélina; Ganea, Natasa; Hudry, Kristelle; Tucker, Leslie; Charman, Tony; Johnson, Mark H.

    2015-01-01

    Summary Eye gaze is a key channel of non-verbal communication in humans [1, 2, 3]. Eye contact with others is present from birth [4], and eye gaze processing is crucial for social learning and adult-infant communication [5, 6, 7]. However, little is known about the effect of selectively different experience of eye contact and gaze communication on early social and communicative development. To directly address this question, we assessed 14 sighted infants of blind parents (SIBPs) longitudinally at 6–10 and 12–16 months. Face scanning [8] and gaze following [7, 9] were assessed using eye tracking. In addition, naturalistic observations were made when the infants were interacting with their blind parent and with an unfamiliar sighted adult. Established measures of emergent autistic-like behaviors [10] and standardized tests of cognitive, motor, and linguistic development [11] were also collected. These data were then compared with those obtained from a group of infants of sighted parents. Despite showing typical social skills development overall, infants of blind parents allocated less attention to adult eye movements and gaze direction, an effect that increased between 6–10 and 12–16 months of age. The results suggest that infants adjust their use of adults’ eye gaze depending on gaze communication experience from early in life. The results highlight that human functional brain development shows selective experience-dependent plasticity adaptive to the individual’s specific social environment. PMID:26752077

  15. Application of CATHARE code to the isolation condenser experiment in PIPER-ONE loop

    SciTech Connect

    D`Auria, F.; Mazzini, M.; Kalli, H.; Sorjonen, J.

    1996-07-01

    CATHARE code has been applied to Isolation Condenser experiment conducted in PIPER-ONE facility. PIPER-ONE simulates a General Electric BWR-6 with volume and height scaling ratios 1/2200 and 1/1, respectively. The integral test facility was properly modified to reproduce typical IC thermal-hydraulic conditions for the test PO-IC-02. The facility was equipped with an once-through heat exchanger immersed in a pool of ambient temperature water, installed roughly 10 m above the core, in aim to reproduce qualitatively the phenomenologies expected for Isolation Condenser in the Simplified BWR (SBWR). The facility is installed in Dipartimento di Costruzioni Meccaniche e Nucleari of Pisa University (I). CATHARE is a thermal-hydraulic computer code developed at the Centre d`Etudes Nucleaires de Grenoble (CENG) for the prediction of nuclear power plant behavior in case of transients. CATHARE2 V1.3E was applied during the activity. Experiment PO-IC-02 included two subsequent power levels with initial pressure of 5.1 MPa. The Isolation Condenser was active during the whole experiment except between the two different power levels. The aim of the calculation was to reproduce the experiment. This was not achieved. CATHARE2 V1.3E calculates too low heat transfer coefficients for condensation of steam.

  16. Prior peritraumatic dissociative experiences affect autonomic reactivity during trauma recall

    PubMed Central

    Sledjeski, Eve M.; Delahanty, Douglas L.

    2012-01-01

    To better understand the psychophysiological correlates of peritraumatic dissociation (PD), the present study examined the relationship between reports of prior PD and sympathetic and parasympathetic functioning in response to a laboratory stress paradigm in 39 traumatized female undergraduates. Participants were asked to talk about their most distressing traumatizing experience while continuous measures of heart rate (HR), pre-ejection period (PEP), and respiratory sinus arrhythmia (RSA) were taken. Overall, high dissociators had significantly larger increases in HR and larger decreases in PEP and RSA during trauma recall. In opposition to our hypothesis, these results suggest that female trauma victims reporting high levels of PD during a prior trauma may be more reactive to traumatic reminders than victims who reported lower levels of PD. PMID:22211440

  17. Sexual experience affects ethanol intake in Drosophila through Neuropeptide F

    PubMed Central

    Shohat-Ophir, G.; Kaun, K.R.; Azanchi, R.; Mohammed, H; Heberlein, U.

    2014-01-01

    The brain's reward systems evolved to reinforce behaviors required for species survival, including sex, food consumption, and social interaction. Drugs of abuse co-opt these neural pathways, which can lead to addiction. Here, we use Drosophila melanogaster to investigate the relationship between natural and drug rewards. In males, mating increased Neuropeptide F (NPF) levels, whereas sexual deprivation reduced NPF. Activation or inhibition of the NPF system in turn enhanced or reduced ethanol preference. These results thus link sexual experience, NPF system activity, and ethanol consumption. Artificial activation of NPF neurons was in itself rewarding and precluded the ability of ethanol to act as a reward. We propose that activity of the NPF/NPF receptor axis represents the state of the fly reward system and modifies behavior accordingly. PMID:22422983

  18. Prior peritraumatic dissociative experiences affect autonomic reactivity during trauma recall.

    PubMed

    Sledjeski, Eve M; Delahanty, Douglas L

    2012-01-01

    To better understand the psychophysiological correlates of peritraumatic dissociation (PD), the present study examined the relationship between reports of prior PD and sympathetic and parasympathetic functioning in response to a laboratory stress paradigm in 39 traumatized female undergraduates. Participants were asked to talk about their most distressing traumatizing experience while continuous measures of heart rate, pre-ejection period, and respiratory sinus arrhythmia were taken. Overall, high dissociators had significantly larger increases in heart rate and larger decreases in pre-ejection period and respiratory sinus arrhythmia during trauma recall. In opposition to our hypothesis, these results suggest that female trauma victims reporting high levels of PD during a prior trauma may be more reactive to traumatic reminders than victims who report lower levels of PD.

  19. What experimental experience affects dogs' comprehension of human communicative actions?

    PubMed

    Hauser, Marc D; Comins, Jordan A; Pytka, Lisa M; Cahill, Donal P; Velez-Calderon, Sofia

    2011-01-01

    Studies of dogs report that individuals reliably respond to the goal-directed communicative actions (e.g., pointing) of human experimenters. All of these studies use some version of a multi-trial approach, thereby allowing for the possibility of rapid learning within an experimental session. The experiments reported here ask whether dogs can respond correctly to a communicative action based on only a single presentation, thereby eliminating the possibility of learning within the experimental context. We tested 173 dogs. For each dog reaching our test criteria, we used a single presentation of six different goal-directed actions within a session, asking whether they correctly follow to a target goal (container with concealed food) a (1) distal hand point, (2) step toward one container, (3) hand point to one container followed by step toward the other, (4) step toward one container and point to the other, (5) distal foot point with the experimenter's hands free, and (6) distal foot point with the experimenter's hands occupied. Given only a single presentation, dogs selected the correct container when the experimenter hand pointed, foot pointed with hands occupied, or stepped closer to the target container, but failed on the other actions, despite using the same method. The fact that dogs correctly followed foot pointing with hands occupied, but not hands free, suggests that they are sensitive to environmental constraints, and use this information to infer rational, goal-directed action. We discuss these results in light of the role of experience in recognizing communicative gestures, as well as the significance of coding criteria for studies of canine competence.

  20. Anticipatory balance control is affected by loadless training experiences.

    PubMed

    Robert, G; Gueguen, N; Avogadro, P; Mouchnino, L

    2004-09-01

    The main purpose of this study was to identify whether a lot of sports training had any effect on the balance control associated with a leg movement. The nature of the training experience was also an important concern and we chose subject who had undergone specific training experience in absence of equilibrium constraints. To this end a comparison between control (untrained) subjects, triathletes and swimmers was designed to establish whether a general training in sports (triathletes) or a specific loadless training (swimmers), leads to differences in the balance control. A leg movement is preceded by a shift of the center of mass (CM) towards the supporting side to maintain equilibrium and forward to create the condition for progression. To provide an acceleration of the CM sideward and forward, an initial displacement of the center of pressure (CP) towards the moving limb and in posterior direction was performed. Interestingly, the lateral pressure onto the ground was greater increased in swimmers in both leg raising and obstacle avoidance tasks compared to the control group and/or triathletes whereas the backward CP shift in all group was the same. The initial control of the CM shift is very different in swimmers compared to triathletes and controls. The increased lateral pressure onto the ground in swimmers may be a result of a prolonged training in water. This suggests that prolonged training in the absence of equilibrium constraints has more of an effect on balance control than a prolonged general training. In addition, the lack of differences in the backward CP shift suggests that M/L and A/P controls support two functional goals: equilibrium maintenance and movement initiation.

  1. Development of a Closed-Loop Strap Down Attitude System for an Ultrahigh Altitude Flight Experiment

    NASA Technical Reports Server (NTRS)

    Whitmore, Stephen A.; Fife, Mike; Brashear, Logan

    1997-01-01

    A low-cost attitude system has been developed for an ultrahigh altitude flight experiment. The experiment uses a remotely piloted sailplane, with the wings modified for flight at altitudes greater than 100,000 ft. Mission requirements deem it necessary to measure the aircraft pitch and bank angles with accuracy better than 1.0 deg and heading with accuracy better than 5.0 deg. Vehicle cost restrictions and gross weight limits make installing a commercial inertial navigation system unfeasible. Instead, a low-cost attitude system was developed using strap down components. Monte Carlo analyses verified that two vector measurements, magnetic field and velocity, are required to completely stabilize the error equations. In the estimating algorithm, body-axis observations of the airspeed vector and the magnetic field are compared against the inertial velocity vector and a magnetic-field reference model. Residuals are fed back to stabilize integration of rate gyros. The effectiveness of the estimating algorithm was demonstrated using data from the NASA Dryden Flight Research Center Systems Research Aircraft (SRA) flight tests. The algorithm was applied with good results to a maximum 10' pitch and bank angles. Effects of wind shears were evaluated and, for most cases, can be safely ignored.

  2. Experience and limited lighting may affect sleepiness of tunnel workers

    PubMed Central

    2014-01-01

    Background Working on shifts, especially on a night shift, influences the endogenous sleep regulation system leading to diminished sleep time and increased somnolence. We attempted to evaluate the impact of shifts on sleepiness and correlate the sleepiness score to the experience in a shift schedule. Materials and methods This cross-sectional study consists of 42 male and 2 female workers involved in a tunnel construction. They underwent spirometry, pulse oximetry and were asked to complete the Epworth Sleepiness Scale questionnaire. Results Statistical analysis revealed that workers of lower Epworth had a mean age of 43.6 years, compared to the mean age of 36.4 years of workers with higher Epworth. Furthermore, workers of lower Epworth were characterized by a mean number of shift years equal to 14.8, while those of higher Epworth possessed a mean number of shift years equal to 8. The shift schedule did not reveal any statistically significant correlation. Conclusions Workers employed for a longer time had diminished sleepiness. However, there is no relationship between night shifts and sleepiness, possibly because of exposure to artificial lighting in the construction site. PMID:24993796

  3. Negative emotional experiences arouse rumination and affect working memory capacity.

    PubMed

    Curci, Antonietta; Lanciano, Tiziana; Soleti, Emanuela; Rimé, Bernard

    2013-10-01

    Following an emotional experience, individuals are confronted with the persistence of ruminative thoughts that disturb the undertaking of other activities. In the present study, we experimentally tested the idea that experiencing a negative emotion triggers a ruminative process that drains working memory (WM) resources normally devoted to other tasks. Undergraduate participants of high versus low WM capacity were administered the operation-word memory span test (OSPAN) as a measure of availability of WM resources preceding and following the presentation of negative emotional versus neutral material. Rumination was assessed immediately after the second OSPAN session and at a 24-hr delay. Results showed that both the individual's WM capacity and the emotional valence of the material influenced WM performance and the persistence of ruminative thoughts. Following the experimental induction, rumination mediated the relationship between the negative emotional state and the concomitant WM performance. Based on these results, we argue that ruminative processes deplete WM resources, making them less available for concurrent tasks; in addition, rumination tends to persist over time. These findings have implications for the theoretical modeling of the long-term effects of emotions in both daily life and clinical contexts.

  4. Conserved phosphorylation sites in the activation loop of the Arabidopsis phytosulfokine receptor PSKR1 differentially affect kinase and receptor activity

    PubMed Central

    Hartmann, Jens; Linke, Dennis; Bönniger, Christine; Tholey, Andreas; Sauter, Margret

    2015-01-01

    PSK (phytosulfokine) is a plant peptide hormone perceived by a leucine-rich repeat receptor kinase. Phosphosite mapping of epitope-tagged PSKR1 (phytosulfokine receptor 1) from Arabidopsis thaliana plants identified Ser696 and Ser698 in the JM (juxtamembrane) region and probably Ser886 and/or Ser893 in the AL (activation loop) as in planta phosphorylation sites. In vitro-expressed kinase was autophosphorylated at Ser717 in the JM, and at Ser733, Thr752, Ser783, Ser864, Ser911, Ser958 and Thr998 in the kinase domain. The LC–ESI–MS/MS spectra provided support that up to three sites (Thr890, Ser893 and Thr894) in the AL were likely to be phosphorylated in vitro. These sites are evolutionarily highly conserved in PSK receptors, indicative of a conserved function. Site-directed mutagenesis of the four conserved residues in the activation segment, Thr890, Ser893, Thr894 and Thr899, differentially altered kinase activity in vitro and growth-promoting activity in planta. The T899A and the quadruple-mutated TSTT-A (T890A/S893A/T894A/T899A) mutants were both kinase-inactive, but PSKR1(T899A) retained growth-promoting activity. The T890A and S893A/T894A substitutions diminished kinase activity and growth promotion. We hypothesize that phosphorylation within the AL activates kinase activity and receptor function in a gradual and distinctive manner that may be a means to modulate the PSK response. PMID:26472115

  5. The Emotional Experience of People with Intellectual Disability: An Analysis Using the International Affective Pictures System

    ERIC Educational Resources Information Center

    Bermejo, Belen G.; Mateos, Pedro M.; Sanchez-Mateos, Juan Degado

    2014-01-01

    The present study provides information on the emotional experience of people with intellectual disability. To evaluate this emotional experience, we have used the International Affective Pictures System (IAPS). The most important result from this study is that the emotional reaction of people with intellectual disability to affective stimuli is…

  6. The Role of Surgeonsʼ Colposcopic Experience in Obtaining Adequate Samples by Large Loop Excision of the Transformation Zone in Women of Reproductive Age

    PubMed Central

    Sparić, R.; Tinelli, A.; Guido, M.; Stefanović, R.; Babović, I.; Kesić, V.

    2016-01-01

    Introduction: There is insufficient reporting on the level of colposcopic training for the safe use of large loop excision of the transformation zone. The aim of this study was to perform a quality assessment of large loop excision of the transformation zone in women of reproductive age by evaluating the surgeonsʼ colposcopic experience. Materials and Methods: A retrospective cohort study was performed on diagnostic or therapeutic large loop excision of the transformation zone. The following variables were analyzed: age, parity, indications for surgery, level of surgeonʼs colposcopic experience, definitive histological diagnosis, margin involvement, and the presence and type of artifacts interfering with the pathological interpretation. Patients were divided into three groups: group A – 75 patients treated by junior colposcopists; group B – 74 patients treated by experienced colposcopists, and group C – 117 patients treated by expert colposcopists. Results: Regarding the presence and diagnostic significance of the artifacts the groups were significantly different. Inadequate samples were the least frequent in group C. Artifacts precluding histological diagnosis were the most common in group A. The margins were predominantly inconclusive in group A. Conclusions: A high rate of artifacts is a disadvantage of the large loop excision of the transformation zone performed by surgeons less skilled for colposcopy. Although large loop excision of the transformation zone is considered to be a minor surgery, skills in colposcopy are an essential prerequisite for optimal results. PMID:28017975

  7. Loop quantization

    SciTech Connect

    Nicolau, A.

    1988-10-01

    Loop unwinding is a known technique for reducing loop overhead, exposing parallelism, and increasing the efficiency of pipelining. Traditional loop unwinding is limited to the innermost loop in a group of nested loops and the amount of unwinding either is fixed or must be specified by the user, on a case by case basis. In this paper the authors present a general technique for automatically unwinding multiply nested loops, explain its advantages over other transformation techniques, and illustrate its practical effectiveness. Lopp Quantization could be beneficial by itself or coupled with other loop transformations.

  8. Evaluation of Airborne Precision Spacing in a Human-in-the-Loop Experiment

    NASA Technical Reports Server (NTRS)

    Barmore, Bryan E.; Abbott, Terence S.; Capron, William R.

    2005-01-01

    A significant bottleneck in the current air traffic system occurs at the runway. Expanding airports and adding new runways will help solve this problem; however, this comes with significant costs: financially, politically and environmentally. A complementary solution is to safely increase the capacity of current runways. This can be achieved by precisely spacing aircraft at the runway threshold, with a resulting reduction in the spacing bu er required under today s operations. At NASA's Langley Research Center, the Airspace Systems program has been investigating airborne technologies and procedures that will assist the flight crew in achieving precise spacing behind another aircraft. A new spacing clearance allows the pilot to follow speed cues from a new on-board guidance system called Airborne Merging and Spacing for Terminal Arrivals (AMSTAR). AMSTAR receives Automatic Dependent Surveillance-Broadcast (ADS-B) reports from an assigned, leading aircraft and calculates the appropriate speed for the ownship to fly to achieve the desired spacing interval, time- or distance-based, at the runway threshold. Since the goal is overall system capacity, the speed guidance algorithm is designed to provide system-wide benefits and stability to a string of arriving aircraft. An experiment was recently performed at the NASA Langley Air Traffic Operations Laboratory (ATOL) to test the flexibility of Airborne Precision Spacing operations under a variety of operational conditions. These included several types of merge and approach geometries along with the complementary merging and in-trail operations. Twelve airline pilots and four controllers participated in this simulation. Performance and questionnaire data were collected from a total of eighty-four individual arrivals. The pilots were able to achieve precise spacing with a mean error of 0.5 seconds and a standard deviation of 4.7 seconds. No statistically significant di erences in spacing performance were found between in

  9. Affect 4.0: a free software package for implementing psychological and psychophysiological experiments.

    PubMed

    Spruyt, Adriaan; Clarysse, Jeroen; Vansteenwegen, Debora; Baeyens, Frank; Hermans, Dirk

    2010-01-01

    We describe Affect 4.0, a user-friendly software package for implementing psychological and psychophysiological experiments. Affect 4.0 can be used to present visual, acoustic, and/or tactile stimuli in highly complex (i.e., semirandomized and response-contingent) sequences. Affect 4.0 is capable of registering response latencies and analog behavioral input with millisecond accuracy. Affect 4.0 is available free of charge.

  10. Is Long-Term Structural Priming Affected by Patterns of Experience with Individual Verbs?

    ERIC Educational Resources Information Center

    Kaschak, Michael P.; Borreggine, Kristin L.

    2008-01-01

    Several recent papers have reported long-term structural priming effects in experiments where previous patterns of experience with the double object and prepositional object constructions are shown to affect later patterns of language production for those constructions. The experiments reported in this paper address the extent to which these…

  11. Exercise Experiences and Changes in Affective Attitude: Direct and Indirect Effects of In Situ Measurements of Experiences

    PubMed Central

    Sudeck, Gorden; Schmid, Julia; Conzelmann, Achim

    2016-01-01

    Objectives: The purpose of this study was to examine the relationship between exercise experiences (perceptions of competence, perceived exertion, acute affective responses to exercise) and affective attitudes toward exercise. This relationship was analyzed in a non-laboratory setting during a 13-weeks exercise program. Materials and Methods: 56 women and 49 men (aged 35–65 years; Mage = 50.0 years; SD = 8.2 years) took part in the longitudinal study. Affective responses to exercise (affective valence, positive activation, calmness) as well as perceptions of competence and perceived exertion were measured at the beginning, during, and end of three exercise sessions within the 13-weeks exercise program. Affective attitude toward exercise were measured before and at the end of the exercise program. A two-level path analysis was conducted. The direct and indirect effects of exercise experiences on changes in affective attitude were analyzed on the between-person level: firstly, it was tested whether perceptions of competence and perceived exertion directly relate to changes in affective attitude. Secondly, it was assessed whether perceptions of competence and perceived exertion indirectly relate to changes in affective attitudes—imparted via the affective response during exercise. Results and Conclusion: At the between-person level, a direct effect on changes in affective attitude was found for perceptions of competence (β = 0.24, p < 0.05). The model revealed one significant indirect pathway between perceived exertion and changes in affective attitude via positive activation: on average, the less strenuous people perceive physical exercise to be, the more awake they will feel during exercise (β = -0.57, p < 0.05). Those people with higher average levels of positive activation during exercise exhibit more improvements in affective attitudes toward exercise from the beginning to the end of the 13-weeks exercise program (β = 0.24, p < 0.05). Main study results

  12. Self-organized synchronization of digital phase-locked loops with delayed coupling in theory and experiment

    PubMed Central

    Wetzel, Lucas; Jörg, David J.; Pollakis, Alexandros; Rave, Wolfgang; Fettweis, Gerhard; Jülicher, Frank

    2017-01-01

    Self-organized synchronization occurs in a variety of natural and technical systems but has so far only attracted limited attention as an engineering principle. In distributed electronic systems, such as antenna arrays and multi-core processors, a common time reference is key to coordinate signal transmission and processing. Here we show how the self-organized synchronization of mutually coupled digital phase-locked loops (DPLLs) can provide robust clocking in large-scale systems. We develop a nonlinear phase description of individual and coupled DPLLs that takes into account filter impulse responses and delayed signal transmission. Our phase model permits analytical expressions for the collective frequencies of synchronized states, the analysis of stability properties and the time scale of synchronization. In particular, we find that signal filtering introduces stability transitions that are not found in systems without filtering. To test our theoretical predictions, we designed and carried out experiments using networks of off-the-shelf DPLL integrated circuitry. We show that the phase model can quantitatively predict the existence, frequency, and stability of synchronized states. Our results demonstrate that mutually delay-coupled DPLLs can provide robust and self-organized synchronous clocking in electronic systems. PMID:28207779

  13. More intense experiences, less intense forecasts: why people overweight probability specifications in affective forecasts.

    PubMed

    Buechel, Eva C; Zhang, Jiao; Morewedge, Carey K; Vosgerau, Joachim

    2014-01-01

    We propose that affective forecasters overestimate the extent to which experienced hedonic responses to an outcome are influenced by the probability of its occurrence. The experience of an outcome (e.g., winning a gamble) is typically more affectively intense than the simulation of that outcome (e.g., imagining winning a gamble) upon which the affective forecast for it is based. We suggest that, as a result, experiencers allocate a larger share of their attention toward the outcome (e.g., winning the gamble) and less to its probability specifications than do affective forecasters. Consequently, hedonic responses to an outcome are less sensitive to its probability specifications than are affective forecasts for that outcome. The results of 6 experiments provide support for our theory. Affective forecasters overestimated how sensitive experiencers would be to the probability of positive and negative outcomes (Experiments 1 and 2). Consistent with our attentional account, differences in sensitivity to probability specifications disappeared when the attention of forecasters was diverted from probability specifications (Experiment 3) or when the attention of experiencers was drawn toward probability specifications (Experiment 4). Finally, differences in sensitivity to probability specifications between forecasters and experiencers were diminished when the forecasted outcome was more affectively intense (Experiments 5 and 6).

  14. More Intense Experiences, Less Intense Forecasts: Why People Overweight Probability Specifications in Affective Forecasts

    PubMed Central

    Buechel, Eva C.; Zhang, Jiao; Morewedge, Carey K.; Vosgerau, Joachim

    2014-01-01

    We propose that affective forecasters overestimate the extent to which experienced hedonic responses to an outcome are influenced by the probability of its occurrence. The experience of an outcome (e.g., winning a gamble) is typically more affectively intense than the simulation of that outcome (e.g., imagining winning a gamble) upon which the affective forecast for it is based. We suggest that, as a result, experiencers allocate a larger share of their attention toward the outcome (e.g., winning the gamble) and less to its probability specifications than do affective forecasters. Consequently, hedonic responses to an outcome are less sensitive to its probability specifications than are affective forecasts for that outcome. The results of 6 experiments provide support for our theory. Affective forecasters overestimated how sensitive experiencers would be to the probability of positive and negative outcomes (Experiments 1 and 2). Consistent with our attentional account, differences in sensitivity to probability specifications disappeared when the attention of forecasters was diverted from probability specifications (Experiment 3) or when the attention of experiencers was drawn toward probability specifications (Experiment 4). Finally, differences in sensitivity to probability specifications between forecasters and experiencers were diminished when the forecasted outcome was more affectively intense (Experiments 5 and 6). PMID:24128184

  15. Ruminative self-focus and negative affect: an experience sampling study.

    PubMed

    Moberly, Nicholas J; Watkins, Edward R

    2008-05-01

    The authors conducted an experience sampling study to investigate the relationship between momentary ruminative self-focus and negative affect. Ninety-three adults recorded these variables at quasi-random intervals 8 times daily for 1 week. Scores on questionnaire measures of dispositional rumination were associated with mean levels of momentary ruminative self-focus over the experience sampling week. Concurrently, momentary ruminative self-focus was positively associated with negative affect. Cross-lagged analyses revealed that whereas ruminative self-focus predicted negative affect at a subsequent occasion, negative affect also predicted ruminative self-focus at a subsequent occasion. Decomposition of the dispositional rumination measure suggested that brooding, but not reflective pondering, was associated with higher mean levels of negative affect. Though broadly consistent with Nolen-Hoeksema's (1991) response styles theory, these results suggest that a reciprocal relationship exists between ruminative self-focus and negative affect.

  16. Investigating Affective Experiences in the Undergraduate Chemistry Laboratory: Students' Perceptions of Control and Responsibility

    ERIC Educational Resources Information Center

    Galloway, Kelli R.; Malakpa, Zoebedeh; Bretz, Stacey Lowery

    2016-01-01

    Meaningful learning requires the integration of cognitive and affective learning with the psychomotor, i.e., hands-on learning. The undergraduate chemistry laboratory is an ideal place for meaningful learning to occur. However, accurately characterizing students' affective experiences in the chemistry laboratory can be a very difficult task. While…

  17. Discrete state model and accurate estimation of loop entropy of RNA secondary structures.

    PubMed

    Zhang, Jian; Lin, Ming; Chen, Rong; Wang, Wei; Liang, Jie

    2008-03-28

    Conformational entropy makes important contribution to the stability and folding of RNA molecule, but it is challenging to either measure or compute conformational entropy associated with long loops. We develop optimized discrete k-state models of RNA backbone based on known RNA structures for computing entropy of loops, which are modeled as self-avoiding walks. To estimate entropy of hairpin, bulge, internal loop, and multibranch loop of long length (up to 50), we develop an efficient sampling method based on the sequential Monte Carlo principle. Our method considers excluded volume effect. It is general and can be applied to calculating entropy of loops with longer length and arbitrary complexity. For loops of short length, our results are in good agreement with a recent theoretical model and experimental measurement. For long loops, our estimated entropy of hairpin loops is in excellent agreement with the Jacobson-Stockmayer extrapolation model. However, for bulge loops and more complex secondary structures such as internal and multibranch loops, we find that the Jacobson-Stockmayer extrapolation model has large errors. Based on estimated entropy, we have developed empirical formulae for accurate calculation of entropy of long loops in different secondary structures. Our study on the effect of asymmetric size of loops suggest that loop entropy of internal loops is largely determined by the total loop length, and is only marginally affected by the asymmetric size of the two loops. Our finding suggests that the significant asymmetric effects of loop length in internal loops measured by experiments are likely to be partially enthalpic. Our method can be applied to develop improved energy parameters important for studying RNA stability and folding, and for predicting RNA secondary and tertiary structures. The discrete model and the program used to calculate loop entropy can be downloaded at http://gila.bioengr.uic.edu/resources/RNA.html.

  18. Elementary Teachers' Experiences of Departmentalized Instruction and Its Impact on Student Affect

    ERIC Educational Resources Information Center

    Minott, Robert Charles

    2016-01-01

    The purpose of this qualitative dissertation was to explore the lived experiences of departmentalized elementary teachers, Grades 1-3, and how they addressed their students' affective needs. The main research question of the study was how do elementary school teachers perceive departmentalized instruction and describe their experiences of this…

  19. An Examination of the Joint Effects of Affective Experiences and Job Beliefs on Job Satisfaction and Variations in Affective Experiences over Time.

    PubMed

    Weiss; Nicholas; Daus

    1999-04-01

    This study investigated the joint influences of episodic levels of pleasant mood at work and beliefs about one's job on judgments of job satisfaction, as well as examining the prediction of the patterns of affective states over time. Twenty-four managerial workers completed a diary during work hours which required them to report their mood state at four different times during the workday. The diaries were completed for 16 workdays. At a separate time they completed a measure of overall satisfaction, a Valence-Instrumentality-Expectancy (VIE) measure of beliefs about the job and two dispositional variables, dispositional happiness and affect intensity. Results showed that average levels of pleasant mood over the 16 days and VIE beliefs about the job made significant and independent contributions to the prediction of overall job satisfaction and did so over and above the contribution of dispositional happiness. Results also indicated that individual differences in affective intensity predicted the variability of pleasant mood over time as well as mean levels of mood activation. Finally, spectral analyses applied to the series of mood observations showed that the variability over time in the series of mood observations showed two definite cycles, one corresponding to a daily cycle and one corresponding to a two-period oscillation in mood. Results are discussed in terms of the joint influences of affective experiences and job beliefs on job attitudes and the importance of studying affect over time independent of job satisfaction. Copyright 1999 Academic Press.

  20. The regulatory gene areA mediating nitrogen metabolite repression in Aspergillus nidulans. Mutations affecting specificity of gene activation alter a loop residue of a putative zinc finger.

    PubMed Central

    Kudla, B; Caddick, M X; Langdon, T; Martinez-Rossi, N M; Bennett, C F; Sibley, S; Davies, R W; Arst, H N

    1990-01-01

    The regulatory gene areA mediating nitrogen metabolite repression in Aspergillus nidulans has been sequenced and its transcript mapped and orientated. A single ORF can encode a protein of 719 amino acids. A 52 amino acid region including a putative 'zinc finger' strongly resembles putative DNA binding regions of the major regulatory protein of erythroid cells. The derived protein sequence also contains a highly acidic region possibly involved in gene activation and 22 copies of the motif S(T)PXX, abundant in DNA binding proteins. Analysis of chromosomal rearrangements and transformation with deletion clones identified 342 N-terminal and 124 C-terminal residues as inessential and localized a C-terminal region required for nitrogen metabolite repressibility. A -1 frameshift eliminating the inessential 122 C-terminal amino acids is a surprising loss-of-function mutation. Extraordinary basicity of the replacement C terminus might explain its phenotype. Mutant sequencing also identified a polypeptide chain termination and several missense mutations, but most interesting are sequence changes associated with specificity mutations. A mutation elevating expression of some structural genes under areA control whilst reducing or not affecting expression of others is a leucine to valine change in the zinc finger loop. It reverts to a partly reciprocal phenotype by replacing the mutant valine by methionine. Images Fig.2 Fig.4 Fig.5 Fig. 8. Fig. 9. PMID:1970293

  1. Cleavage of the sarcin–ricin loop of 23S rRNA differentially affects EF-G and EF-Tu binding

    PubMed Central

    García-Ortega, Lucía; Álvarez-García, Elisa; Gavilanes, José G.; Martínez-del-Pozo, Álvaro; Joseph, Simpson

    2010-01-01

    Ribotoxins are potent inhibitors of protein biosynthesis and inactivate ribosomes from a variety of organisms. The ribotoxin α-sarcin cleaves the large 23S ribosomal RNA (rRNA) at the universally conserved sarcin–ricin loop (SRL) leading to complete inactivation of the ribosome and cellular death. The SRL interacts with translation factors that hydrolyze GTP, and it is important for their binding to the ribosome, but its precise role is not yet understood. We studied the effect of α-sarcin on defined steps of translation by the bacterial ribosome. α-Sarcin-treated ribosomes showed no defects in mRNA and tRNA binding, peptide-bond formation and sparsomycin-dependent translocation. Cleavage of SRL slightly affected binding of elongation factor Tu ternary complex (EF-Tu•GTP•tRNA) to the ribosome. In contrast, the activity of elongation factor G (EF-G) was strongly impaired in α-sarcin-treated ribosomes. Importantly, cleavage of SRL inhibited EF-G binding, and consequently GTP hydrolysis and mRNA–tRNA translocation. These results suggest that the SRL is more critical in EF-G than ternary complex binding to the ribosome implicating different requirements in this region of the ribosome during protein elongation. PMID:20215430

  2. How sensory experiences of children with and without autism affect family occupations.

    PubMed

    Bagby, Molly Shields; Dickie, Virginia A; Baranek, Grace T

    2012-01-01

    We used a grounded theory approach to data analysis to discover what effect, if any, children's sensory experiences have on family occupations. We chose this approach because the existing literature does not provide a theory to account for the effect of children's sensory experiences on family occupations. Parents of six children who were typically developing and six children who had autism were interviewed. We analyzed the data using open, axial, and selective coding techniques. Children's sensory experiences affect family occupations in three ways: (1) what a family chooses to do and not to do; (2) how the family prepares; and (3) the extent to which experiences, meaning, and feelings are shared.

  3. Right hemisphere involvement in depression: toward a neuropsychological theory of negative affective experiences.

    PubMed

    Otto, M W; Yeo, R A; Dougher, M J

    1987-10-01

    Several lines of inquiry provide converging evidence for a critical role for the right cerebral hemisphere in negative affective experiences. This research includes the assessment of affective consequences of both focal cerebral lesions and pharmacological inactivation of one or the other hemisphere, as well as experimental and physiological techniques assessing differential hemispheric activation. The specific nature of right hemispheric involvement is conceptualized as a tendency to become activated by aversive experiences, and once activated, to process stimuli in a manner consistent with the right hemisphere's more negative affective tone. A theory of right hemisphere involvement in depressive affect is presented in detail and its relevance to clinical phenomena, e.g., the co-occurrence of depression and pain, and sex differences in depression, is examined, as is congruence with cognitive theories of depression.

  4. Belgian experience in applying the {open_quotes}leak-before-break{close_quotes} concept to the primary loop piping

    SciTech Connect

    Gerard, R.; Malekian, C.; Meessen, O.

    1997-04-01

    The Leak Before Break (LBB) concept allows to eliminate from the design basis the double-ended guillotine break of the primary loop piping, provided it can be demonstrated by a fracture mechanics analysis that a through-wall flaw, of a size giving rise to a leakage still well detectable by the plant leak detection systems, remains stable even under accident conditions (including the Safe Shutdown Earthquake (SSE)). This concept was successfully applied to the primary loop piping of several Belgian Pressurized Water Reactor (PWR) units, operated by the Utility Electrabel. One of the main benefits is to permit justification of supports in the primary loop and justification of the integrity of the reactor pressure vessel and internals in case of a Loss Of Coolant Accident (LOCA) in stretch-out conditions. For two of the Belgian PWR units, the LBB approach also made it possible to reduce the number of large hydraulic snubbers installed on the primary coolant pumps. Last but not least, the LBB concept also facilitates the steam generator replacement operations, by eliminating the need for some pipe whip restraints located close to the steam generator. In addition to the U.S. regulatory requirements, the Belgian safety authorities impose additional requirements which are described in details in a separate paper. An novel aspect of the studies performed in Belgium is the way in which residual loads in the primary loop are taken into account. Such loads may result from displacements imposed to close the primary loop in a steam generator replacement operation, especially when it is performed using the {open_quote}two cuts{close_quotes} technique. The influence of such residual loads on the LBB margins is discussed in details and typical results are presented.

  5. Both Direct and Vicarious Experiences of Nature Affect Children’s Willingness to Conserve Biodiversity

    PubMed Central

    Soga, Masashi; Gaston, Kevin J.; Yamaura, Yuichi; Kurisu, Kiyo; Hanaki, Keisuke

    2016-01-01

    Children are becoming less likely to have direct contact with nature. This ongoing loss of human interactions with nature, the extinction of experience, is viewed as one of the most fundamental obstacles to addressing global environmental challenges. However, the consequences for biodiversity conservation have been examined very little. Here, we conducted a questionnaire survey of elementary schoolchildren and investigated effects of the frequency of direct (participating in nature-based activities) and vicarious experiences of nature (reading books or watching TV programs about nature and talking about nature with parents or friends) on their affective attitudes (individuals’ emotional feelings) toward and willingness to conserve biodiversity. A total of 397 children participated in the surveys in Tokyo. Children’s affective attitudes and willingness to conserve biodiversity were positively associated with the frequency of both direct and vicarious experiences of nature. Path analysis showed that effects of direct and vicarious experiences on children’s willingness to conserve biodiversity were mediated by their affective attitudes. This study demonstrates that children who frequently experience nature are likely to develop greater emotional affinity to and support for protecting biodiversity. We suggest that children should be encouraged to experience nature and be provided with various types of these experiences. PMID:27231925

  6. Quality of social experience explains the relation between extraversion and positive affect.

    PubMed

    Smillie, Luke D; Wilt, Joshua; Kabbani, Rachel; Garratt, Claire; Revelle, William

    2015-06-01

    The personality trait extraversion is associated with higher positive affect, and individuals who behave in an extraverted way experience increased positive affect. Across 2 studies, we examine whether the positive affectivity of extraverts can be explained in terms of qualitative aspects of social experience resulting from extraverted (i.e., bold, assertive) behavior. In our first study (N = 225, 58% female), we found that social well-being, a broad measure of quality of social life (Keyes, 1998) was a significant mediator of the relation between trait extraversion and trait positive affect. This effect was specific to 1 aspect of social well-being-social contribution, one's sense of making an impact on one's social world. In our second study (N = 81, 75% female), we found that a momentary assessment of social well-being mediated the effect of experimentally manipulated extraverted behavior (in the context of 2 brief discussion tasks) on state positive affect. Furthermore, perceived contribution to the discussion tasks accounted for up to 70% of the effect of enacted extraversion on positive affect. This is the first identified mediator of the effect of enacted extraversion on positive affect. Implications and suggestions for extensions of this research are discussed.

  7. Closed-Loop System Identification Experience for Flight Control Law and Flying Qualities Evaluation of a High Performance Fighter Aircraft

    NASA Technical Reports Server (NTRS)

    Murphy, Patrick C.

    1996-01-01

    This paper highlights some of the results and issues associated with estimating models to evaluate control law design methods and design criteria for advanced high performance aircraft. Experimental fighter aircraft such as the NASA-High Alpha Research Vehicle (HARV) have the capability to maneuver at very high angles of attack where nonlinear aerodynamics often predominate. HARV is an experimental F/A-18, configured with thrust vectoring and conformal actuated nose strakes. Identifying closed-loop models for this type of aircraft can be made difficult by nonlinearities and high order characteristics of the system. In this paper, only lateral-directional axes are considered since the lateral-directional control law was specifically designed to produce classical airplane responses normally expected with low-order, rigid-body systems. Evaluation of the control design methodology was made using low-order equivalent systems determined from flight and simulation. This allowed comparison of the closed-loop rigid-body dynamics achieved in flight with that designed in simulation. In flight, the On Board Excitation System was used to apply optimal inputs to lateral stick and pedals at five angles at attack : 5, 20, 30, 45, and 60 degrees. Data analysis and closed-loop model identification were done using frequency domain maximum likelihood. The structure of identified models was a linear state-space model reflecting classical 4th-order airplane dynamics. Input time delays associated with the high-order controller and aircraft system were accounted for in data preprocessing. A comparison of flight estimated models with small perturbation linear design models highlighted nonlinearities in the system and indicated that the closed-loop rigid-body dynamics were sensitive to input amplitudes at 20 and 30 degrees angle of attack.

  8. Closed-Loop System Identification Experience for Flight Control Law and Flying Qualities Evaluation of a High Performance Fighter Aircraft

    NASA Technical Reports Server (NTRS)

    Murphy, Patrick C.

    1999-01-01

    This paper highlights some of the results and issues associated with estimating models to evaluate control law design methods and design criteria for advanced high performance aircraft. Experimental fighter aircraft such as the NASA High Alpha Research Vehicle (HARV) have the capability to maneuver at very high angles of attack where nonlinear aerodynamics often predominate. HARV is an experimental F/A-18, configured with thrust vectoring and conformal actuated nose strakes. Identifying closed-loop models for this type of aircraft can be made difficult by nonlinearities and high-order characteristics of the system. In this paper only lateral-directional axes are considered since the lateral-directional control law was specifically designed to produce classical airplane responses normally expected with low-order, rigid-body systems. Evaluation of the control design methodology was made using low-order equivalent systems determined from flight and simulation. This allowed comparison of the closed-loop rigid-body dynamics achieved in flight with that designed in simulation. In flight, the On Board Excitation System was used to apply optimal inputs to lateral stick and pedals at five angles of attack: 5, 20, 30, 45, and 60 degrees. Data analysis and closed-loop model identification were done using frequency domain maximum likelihood. The structure of the identified models was a linear state-space model reflecting classical 4th-order airplane dynamics. Input time delays associated with the high-order controller and aircraft system were accounted for in data preprocessing. A comparison of flight estimated models with small perturbation linear design models highlighted nonlinearities in the system and indicated that the estimated closed-loop rigid-body dynamics were sensitive to input amplitudes at 20 and 30 degrees angle of attack.

  9. Affective Disruptions of "the" Immigrant Experience: Becomings in Official Language Education Research in Canada

    ERIC Educational Resources Information Center

    Waterhouse, Monica; Arnott, Stephanie

    2016-01-01

    Our purpose is to use a Deleuzian-informed conceptual and theoretical framework to disrupt predominant representations of "the" immigrant experience in Canadian official language education and to open up to the affective potential of "an" immigrant life to become otherwise. Employing a rhizoanalytic research approach that…

  10. Early Experiences Can Alter Gene Expression and Affect Long-Term Development. Working Paper #10

    ERIC Educational Resources Information Center

    National Scientific Council on the Developing Child, 2010

    2010-01-01

    New scientific research shows that environmental influences can actually affect whether and how genes are expressed. Thus, the old ideas that genes are "set in stone" or that they alone determine development have been disproven. In fact, scientists have discovered that early experiences can determine how genes are turned on and off and even…

  11. The Dynamic Nature of Leisure Experience: An Application of Affect Control Theory.

    ERIC Educational Resources Information Center

    Lee, BongKoo; Shafer, C. Scott

    2002-01-01

    Applied Affect Control Theory (ACT) to investigate the interaction process between leisure participants and their environment. Surveys of people on an urban, multiple-use trail indicated that most exhibited a dynamic emotional experience even though they were in the setting a short time. Respondents exhibited different emotions across events.…

  12. Significant Life Experiences Affect Environmental Action: A Confirmation Study in Eastern Taiwan

    ERIC Educational Resources Information Center

    Hsu, Shih-Jang

    2009-01-01

    Two field studies form the basis of this article. The major purposes of Study 1 were to examine significant life experiences affecting the cultivation of environmental activists in eastern Taiwan, and to reconstruct the life paths followed by those active people who engaged in effective environmental action. 40 usable autobiographical memories…

  13. Experiences of School Principals with Newcomers from War-Affected Countries in Africa

    ERIC Educational Resources Information Center

    Okoko, Janet Mola

    2011-01-01

    This article is based on the results of an exploratory study of experiences of 2 urban school principals about leading schools with immigrants from war-affected countries in Africa. It examines how they perceived their preparation for multicultural leadership, and explores lessons that leadership development institutions can learn from their…

  14. Experiences and Implications of Social Workers Practicing in a Pediatric Hospital Environment Affected by SARS

    ERIC Educational Resources Information Center

    Gearing, Robin Edward; Saini, Michael; McNeill, Ted

    2007-01-01

    This phenomenological study's purpose was threefold: to detail the experiences of social workers practicing in a hospital environment affected by severe acute respiratory syndrome (SARS), to describe essential themes and structures of social work practices within this crisis environment, and to explore recommendations for better preparedness to…

  15. User Experience of Mobile Interactivity: How Do Mobile Websites Affect Attitudes and Relational Outcomes?

    ERIC Educational Resources Information Center

    Dou, Xue

    2013-01-01

    Mobile media offer new opportunities for fostering communications between individuals and companies. Corporate websites are being increasingly accessed via smart phones and companies are scrambling to offer a mobile-friendly user experience on their sites. However, very little is known about how interactivity in the mobile context affects user…

  16. Does Day-Care Experience Affect Young Children's Judgments of Home and School Rules?

    ERIC Educational Resources Information Center

    Crane, Dushka A.; Tisak, Marie S.

    1995-01-01

    Examined whether amount of experience in day care affects children's ability to distinguish moral rules from conventional school-based and home-based rules. Preschoolers were questioned about legitimacy of authority of abolishing a rule and their rating of behaviors permitted and prohibited by an authority. Results revealed that previous day-care…

  17. Utilisation of the magnetic sensor in a smartphone for facile magnetostatics experiment: magnetic field due to electrical current in straight and loop wires

    NASA Astrophysics Data System (ADS)

    Septianto, R. D.; Suhendra, D.; Iskandar, F.

    2017-01-01

    This paper reports on the result of a research into the utilisation of a smartphone for the study of magnetostatics on the basis of experiments. The use of such a device gives great measurement result and thus it can replace magnetic sensor tools that are relatively expensive. For the best experimental result, firstly the position of the magnetic sensor in the smartphone has to be considered by way of value mapping of a magnetic field due to permanent magnet. The magnetostatics experiment investigated in this research was the measurement of magnetic field due to electrical currents in two shapes of wire, straight and looped. The current flow, the distance between the observation point and the wire, and the diameter of the loop were the variable parameters investigated to test the smartphone’s capabilities as a measurement tool. To evaluate the experimental results, the measured data were compared with theoretical values that were calculated by using both an analytical and a numerical approach. According to the experiment results, the measured data had good agreement with the results from the analytical and the numerical approach. This means that the use of the magnetic sensor in a smartphone in physics experiments is viable, especially for magnetic field measurement.

  18. Trait Dissociation and the Subjective Affective, Motivational, and Phenomenological Experience of Self-Defining Memories

    PubMed Central

    Sutin, Angelina R.; Stockdale, Gary D.

    2010-01-01

    The present research reports two studies that examine the relation between non-pathological trait dissociation and the subjective affect, motivation, and phenomenology of self-defining memories. In Study 1 (N=293), participants retrieved and rated the emotional and motivational experience of a general and a positive and negative achievement-related memory. Study 2 (N=449) extended these ratings to relationship-related memories and the phenomenological experience of the memory. Dissociation was associated with incongruent affect in valenced memories (e.g., positive affect in a negative memory) and memories that were visually incoherent and saturated with power motivation, hubristic pride, and shame, regardless of valence or domain. The present findings demonstrate that autobiographical memories, which integrate emotional, motivational, and phenomenological components, reflect the emotional and motivational processes inherent to dissociation. PMID:21204840

  19. On the relationship between personal experience, affect and risk perception: The case of climate change

    PubMed Central

    van der Linden, Sander

    2014-01-01

    Examining the conceptual relationship between personal experience, affect, and risk perception is crucial in improving our understanding of how emotional and cognitive process mechanisms shape public perceptions of climate change. This study is the first to investigate the interrelated nature of these variables by contrasting three prominent social-psychological theories. In the first model, affect is viewed as a fast and associative information processing heuristic that guides perceptions of risk. In the second model, affect is seen as flowing from cognitive appraisals (i.e., affect is thought of as a post-cognitive process). Lastly, a third, dual-process model is advanced that integrates aspects from both theoretical perspectives. Four structural equation models were tested on a national sample (N = 808) of British respondents. Results initially provide support for the “cognitive” model, where personal experience with extreme weather is best conceptualized as a predictor of climate change risk perception and, in turn, risk perception a predictor of affect. Yet, closer examination strongly indicates that at the same time, risk perception and affect reciprocally influence each other in a stable feedback system. It is therefore concluded that both theoretical claims are valid and that a dual-process perspective provides a superior fit to the data. Implications for theory and risk communication are discussed. © 2014 The Authors. European Journal of Social Psychology published by John Wiley & Sons, Ltd. PMID:25678723

  20. Paced mating behavior is affected by clitoral-vaginocervical lidocaine application in combination with sexual experience.

    PubMed

    Meerts, Sarah H; Strnad, Helen K; Schairer, Rosemary S

    2015-03-01

    The present study tested the effects of lidocaine anesthetic ointment applied to the vaginocervical (Experiment 1) or clitoral-vaginocervical (Experiment 2) areas on the display of paced mating behavior over the course of five weekly tests in ovariectomized, hormone-primed, Long-Evans rats. Experiment 3 tested whether rats that acquired sexual experience without ointment application would exhibit altered paced mating behavior on a fifth test under clitoral-vaginocervical lidocaine or vehicle application. Although rats in Experiment 1 and Experiment 2 exhibited shorter contact-return latencies after intromission and reduced likelihood of leaving the male compartment following mounts and intromissions after gaining sexual experience, only rats that received clitoral-vaginocervical lidocaine exhibited altered paced mating behavior relative to vehicle. Specifically, clitoral-vaginocervical lidocaine resulted in shorter contact-return latency to ejaculation and greater percentage of time with the male. Paced mating behavior of sexually experienced rats in Experiment 3 was not disrupted when tested after clitoral-vaginocervical lidocaine treatment. Together, these studies suggest that the sensory input during repeated mating encounters affects the pattern of paced mating behavior that develops with sexual experience.

  1. The response of an egg parasitoid to substrate-borne semiochemicals is affected by previous experience

    PubMed Central

    Peri, Ezio; Salerno, Gianandrea; Slimani, Takoua; Frati, Francesca; Conti, Eric; Colazza, Stefano; Cusumano, Antonino

    2016-01-01

    Animals can adjust their behaviour according to previous experience gained during foraging. In parasitoids, experience plays a key role in host location, a hierarchical process in which air-borne and substrate-borne semiochemicals are used to find hosts. In nature, chemical traces deposited by herbivore hosts when walking on the plant are adsorbed by leaf surfaces and perceived as substrate-borne semiochemicals by parasitoids. Chemical traces left on cabbage leaves by adults of the harlequin bug (Murgantia histrionica) induce an innate arrestment response in the egg parasitoid Trissolcus brochymenae characterized by an intense searching behaviour on host-contaminated areas. Here we investigated whether the T. brochymenae response to host walking traces left on leaf surfaces is affected by previous experience in the context of parasitoid foraging behaviour. We found that: 1) an unrewarded experience (successive encounters with host-contaminated areas without successful oviposition) decreased the intensity of the parasitoid response; 2) a rewarded experience (successful oviposition) acted as a reinforcing stimulus; 3) the elapsed time between two consecutive unrewarded events affected the parasitoid response in a host-gender specific manner. The ecological role of these results to the host location process of egg parasitoids is discussed. PMID:27250870

  2. Reconciling cognitive and affective neuroscience perspectives on the brain basis of emotional experience.

    PubMed

    Panksepp, Jaak; Lane, Richard D; Solms, Mark; Smith, Ryan

    2016-09-15

    The "affective" and "cognitive" neuroscience approaches to understanding emotion (AN and CN, respectively) represent potentially synergistic, but as yet unreconciled, theoretical perspectives, which may in part stem from the methods that these distinct perspectives routinely employ-one focusing on animal brain emotional systems (AN) and one on diverse human experimental approaches (CN). Here we present an exchange in which each approach (1) describes its own theoretical perspective, (2) offers a critique of the other perspective, and then (3) responds to each other's critique. We end with a summary of points of agreement and disagreement, and describe possible future experiments that could help resolve the remaining controversies. Future work should (i) further characterize the structure/function of subcortical circuitry with respect to its role in generating emotion, and (ii) further investigate whether sub-neocortical activations alone are sufficient (as opposed to merely necessary) for affective experiences, or whether subsequent cortical representation of an emotional response is also required.

  3. Life Experiences of People Affected by Crohn's Disease and Their Support Networks: Scoping Review.

    PubMed

    García-Sanjuán, Sofía; Lillo-Crespo, Manuel; Sanjuán-Quiles, Ángela; Gil-González, Diana; Richart-Martínez, Miguel

    2016-02-01

    This scoping review identifies and describes relevant studies related to the evidence published on life experiences and perceived social support of people affected by Crohn's disease. Twenty-three studies were definitely selected and analyzed for the topics explored. The overall findings show patients' needs and perceptions. There is a lack of evidence about patients' perceived needs as well as the understanding of social support that has contributed to improve their life experiences with that chronic illness. Lack of energy, loss of body control, body image damaged due to different treatments and surgeries, symptoms related to fear of disease, feeling burdened loss related to independence, and so on are some of the concerns with having to live with those affected by the Crohn. To underline those experiences through this scoping review provides valuable data for health care teams, especially for the nursing profession, considered by those affected as one of the main roles along the whole pathological process. This review provides the basis for developing broader research on the relatively underexplored topics and consequently improves specific programs that could address patients' needs.

  4. Facilities, breed and experience affect ease of sheep handling: the livestock transporter's perspective.

    PubMed

    Burnard, C L; Pitchford, W S; Hocking Edwards, J E; Hazel, S J

    2015-08-01

    An understanding of the perceived importance of a variety of factors affecting the ease of handling of sheep and the interactions between these factors is valuable in improving profitability and welfare of the livestock. Many factors may contribute to animal behaviour during handling, and traditionally these factors have been assessed in isolation under experimental conditions. A human social component to this phenomenon also exists. The aim of this study was to gain a deeper understanding of the importance of a variety of factors affecting ease of handling, and the interactions between these from the perspective of the livestock transporter. Qualitative interviews were used to investigate the factors affecting sheep behaviour during handling. Interview transcripts underwent thematic analysis. Livestock transporters discussed the effects of attitudes and behaviours towards sheep, helpers, facilities, distractions, environment, dogs and a variety of sheep factors including breed, preparation, experience and sex on sheep behaviour during handling. Transporters demonstrated care and empathy and stated that patience and experience were key factors determining how a person might deal with difficult sheep. Livestock transporters strongly believed facilities (ramps and yards) had the greatest impact, followed by sheep experience (naivety of the sheep to handling and transport) and breed. Transporters also discussed the effects of distractions, time of day, weather, dogs, other people, sheep preparation, body condition and sheep sex on ease of handling. The concept of individual sheep temperament was indirectly expressed.

  5. Deletion of the PB-loop in the L(CM) subunit does not affect phycobilisome assembly or energy transfer functions in the cyanobacterium Synechocystis sp. PCC6714.

    PubMed

    Ajlani, G; Vernotte, C

    1998-10-01

    In cyanobacteria, light energy is mainly harvested for photosynthesis by the phycobilisome (PBS): a large pigment-protein complex. This complex is composed of heterodimeric phycobiliproteins that are assembled with the aid of linker polypeptides in order to optimize light-energy absorbance and transfer to photosystem II. The core membrane linker subunit (L(CM)) is a fascinating multifunctional polypeptide that participates in the PBS structure, function and anchoring to the photosynthetic membrane. Sequence analysis has defined several domains within the L(CM) polypeptide. The C-terminal portion contains two to four repeated domains that are similar to the conserved domains of linker polypeptides and are believed to play the same role. The N-terminal portion is similar to phycobiliproteins (PB-domain) and carries, like phycobiliproteins, a covalently linked phycobilin chromophore. This domain is interrupted by a so-called PB-loop insertion. The PB-domain of the L(CM) is thus regarded as one of the core subunits, with its PB-loop protruding towards the photosynthetic membrane. The PB-loop was thought to be involved in the attachment of the PBS to the photosynthetic membrane. We generated an apcE gene (encoding L(CM)), in which we deleted the sequence encoding 54 amino acids of the PB-loop domain. The modified gene was expressed in a Synechocystis PCC6714 strain in which the apcE gene had been inactivated. The truncated polypeptide was functionally equivalent to the wild-type L(CM); PBSs were assembled and functioned as in the wild-type. The PB-loop of the L(CM) seems thus dispensable for the PBS biogenesis and function.

  6. Vasovagal syncope and blood donor return: examination of the role of experience and affective expectancies.

    PubMed

    Olatunji, Bunmi O; Etzel, Erin N; Ciesielski, Bethany G

    2010-03-01

    Vasovagal sensations (e.g., dizziness, nausea, and fainting) are one of the main reasons people find blood donation unpleasant. A better understanding of predictors of vasovagal sensations during blood donation could inform interventions designed to increase donor return rates. The present investigation examined the extent to which experience with blood donation and vasovagal sensations during blood donation uniquely predict the likelihood of donor return, even when controlling for affective expectancies. Participants presenting at community blood drives indicated how many times they have given blood and provided ratings of expected anxiety, pain, disgust, as well as fear of fainting before giving blood. After donating, participants completed a measure of vasovagal sensations experienced during blood donation. They also rated the pleasantness of the experience and willingness to donate blood in the future. The findings showed that experience with blood donation and vasovagal sensations during blood donation uniquely predicted willingness to donate blood in the future even when controlling for age and negative affective expectancies about giving blood. This finding suggests that vasovagal sensations and experience with blood donation have unique (and perhaps additive) effects on willingness to donate blood in the future, suggesting that behavior modification interventions that directly target these variables could potentially increase donor retention.

  7. Social experiences during adolescence affect anxiety-like behavior but not aggressiveness in male mice.

    PubMed

    Meyer, Neele; Jenikejew, Julia; Richter, S Helene; Kaiser, Sylvia; Sachser, Norbert

    2017-03-09

    Adolescence has lately been recognized as a key developmental phase during which an individual's behavior can be shaped. In a recent study with male mice varying in the expression of the serotonin transporter, escapable adverse social experiences during adolescence led to decreased anxiety-like behavior and increased exploratory and aggressive behavior compared to throughout beneficial experiences. Since in this study some behavioral tests took place with a delay of one week after the last social experiences have been made, it was not clear whether the observed effects really reflected the consequences of the experienced different social environments. To test this, the present study focused on the direct effects of beneficial and adverse social experiences on aggressiveness and anxiety-like behavior in C57BL/6J mice. In contrast to the previous study, behavioral testing took place immediately after the last social experiences had been made. Interestingly, whereas individuals from an escapable adverse environment showed significantly lower levels of anxiety-like and higher levels of exploratory behavior than animals from a beneficial environment, aggressive behavior was not affected. From this, we conclude that different social experiences during adolescence exert immediate effects on anxiety-like but not aggressive behavior in male mice.

  8. Loop Heat Pipe Startup Behaviors

    NASA Technical Reports Server (NTRS)

    Ku, Jentung

    2016-01-01

    A loop heat pipe must start successfully before it can commence its service. The startup transient represents one of the most complex phenomena in the loop heat pipe operation. This paper discusses various aspects of loop heat pipe startup behaviors. Topics include the four startup scenarios, the initial fluid distribution between the evaporator and reservoir that determines the startup scenario, factors that affect the fluid distribution between the evaporator and reservoir, difficulties encountered during the low power startup, and methods to enhance the startup success. Also addressed are the pressure spike and pressure surge during the startup transient, and repeated cycles of loop startup and shutdown under certain conditions.

  9. Teachers' Perception of Looping in Secondary Schools

    ERIC Educational Resources Information Center

    Chakey, Dennis J.

    2014-01-01

    The purpose of this qualitative study was to gain an understanding of secondary teachers' perception of the looping process. The research questions revealed teachers' opinions of the looping process and its impact on the overall educational experience. Participants within this study had experiences teaching within the looping process and within a…

  10. CO2 multicyclic capture of pretreated/doped CaO in the Ca-looping process. Theory and experiments.

    PubMed

    Valverde, Jose M; Sanchez-Jimenez, Pedro E; Perejon, Antonio; Perez-Maqueda, Luis A

    2013-07-28

    We study in this paper the conversion of CaO-based CO2 sorbents when subjected to repeated carbonation-calcination cycles with a focus on thermally pretreated/doped sorbents. Analytical equations are derived to describe the evolution of conversion with the cycle number from a unifying model based on the balance between surface area loss due to sintering in the looping-calcination stage and surface area regeneration as a consequence of solid-state diffusion during the looping-carbonation stage. Multicyclic CaO conversion is governed by the evolution of surface area loss/regeneration that strongly depends on the initial state of the pore skeleton. In the case of thermally pretreated sorbents, the initial pore skeleton is highly sintered and regeneration is relevant, whereas for nonpretreated sorbents the initial pore skeleton is soft and regeneration is negligible. Experimental results are obtained for sorbents subjected to a preheating controlled rate thermal analysis (CRTA) program. By applying this preheating program in a CO2 enriched atmosphere, CaO can be subjected to a rapid carbonation followed by a slow rate controlled decarbonation, which yields a highly sintered skeleton displaying a small conversion in the first cycle and self-reactivation in the next ones. Conversely, carbonation of the sorbent at a slow controlled rate enhances CO2 solid-state diffusion, which gives rise, after a quick decarbonation, to a highly porous skeleton. In this case, CaO conversion in the first cycle is very large but it decays abruptly in subsequent cycles. Data for CaO conversion retrieved from the literature and from further experimental measurements performed in our work are analyzed as influenced by a variety of experimental variables such as preheating temperature program, preheating exposition time, atmosphere composition, presence of additives, and carbonation-calcination conditions. Conversion data are well fitted by the proposed model equations, which are of help for a

  11. Dealing with stigma: experiences of persons affected by disabilities and leprosy.

    PubMed

    Lusli, Mimi; Zweekhorst, Marjolein B M; Miranda-Galarza, Beatriz; Peters, Ruth M H; Cummings, Sarah; Seda, Francisia S S E; Bunders, Joske F G; Irwanto

    2015-01-01

    Persons affected by leprosy or by disabilities face forms of stigma that have an impact on their lives. This study seeks to establish whether their experiences of stigma are similar, with a view to enabling the two groups of people to learn from each other. Accounts of experiences of the impact of stigma were obtained using in-depth interviews and focus group discussion with people affected by leprosy and by disabilities not related to leprosy. The analysis shows that there are a lot of similarities in impact of stigma in terms of emotions, thoughts, behaviour, and relationships between the two groups. The main difference is that those affected by leprosy tended to frame their situation in medical terms, while those living with disabilities described their situation from a more social perspective. In conclusion, the similarities offer opportunities for interventions and the positive attitudes and behaviours can be modelled in the sense that both groups can learn and benefit. Research that tackles different aspects of stigmatization faced by both groups could lead to inclusive initiatives that help individuals to come to terms with the stigma and to advocate against exclusion and discrimination.

  12. Early experience affects adult personality in the red junglefowl: A role for cognitive stimulation?

    PubMed

    Zidar, Josefina; Sorato, Enrico; Malmqvist, Ann-Marie; Jansson, Emelie; Rosher, Charlotte; Jensen, Per; Favati, Anna; Løvlie, Hanne

    2017-01-01

    Despite intense research efforts, biologists are still puzzled by the existence of animal personality. While recent studies support a link between cognition and personality, the directionality of this relationship still needs to be clarified. Early-life experiences can affect adult behaviour, and among these, cognitive stimulation has been suggested theoretically to influence personality. Yet, the influence of early cognitive stimulation has rarely been explored in empirical investigations of animal behaviour and personality. We investigated the effect of early cognitive stimulation on adult personality in the red junglefowl (Gallus gallus). To this end, we assessed adult behaviour across a number of personality assays and compared behaviour of individuals previously exposed to a series of learning tasks as chicks, with that of control individuals lacking this experience. We found that individuals exposed to early stimulation were, as adults, more vigilant and performed fewer escape attempts in personality assays. Other behaviours describing personality traits in the fowl were not affected. We conclude that our results support the hypothesis that early stimulation can affect aspects of adult behaviour and personality, suggesting a hitherto underappreciated causality link between cognition and personality. Future research should aim to confirm these findings and resolve their underlying dynamics and proximate mechanisms.

  13. Local Navon letter processing affects skilled behavior: a golf-putting experiment.

    PubMed

    Lewis, Michael B; Dawkins, Gemma

    2015-04-01

    Expert or skilled behaviors (for example, face recognition or sporting performance) are typically performed automatically and with little conscious awareness. Previous studies, in various domains of performance, have shown that activities immediately prior to a task demanding a learned skill can affect performance. In sport, describing the to-be-performed action is detrimental, whereas in face recognition, describing a face or reading local Navon letters is detrimental. Two golf-putting experiments are presented that compare the effects that these three tasks have on experienced and novice golfers. Experiment 1 found a Navon effect on golf performance for experienced players. Experiment 2 found, for experienced players only, that performance was impaired following the three tasks described above, when compared with reading or global Navon tasks. It is suggested that the three tasks affect skilled performance by provoking a shift from automatic behavior to a more analytic style. By demonstrating similarities between effects in face recognition and sporting behavior, it is hoped to better understand concepts in both fields.

  14. Loop-to-loop coupling.

    SciTech Connect

    Warne, Larry Kevin; Lucero, Larry Martin; Langston, William L.; Salazar, Robert Austin; Coleman, Phillip Dale; Basilio, Lorena I.; Bacon, Larry Donald

    2012-05-01

    This report estimates inductively-coupled energy to a low-impedance load in a loop-to-loop arrangement. Both analytical models and full-wave numerical simulations are used and the resulting fields, coupled powers and energies are compared. The energies are simply estimated from the coupled powers through approximations to the energy theorem. The transmitter loop is taken to be either a circular geometry or a rectangular-loop (stripline-type) geometry that was used in an experimental setup. Simple magnetic field models are constructed and used to estimate the mutual inductance to the receiving loop, which is taken to be circular with one or several turns. Circuit elements are estimated and used to determine the coupled current and power (an equivalent antenna picture is also given). These results are compared to an electromagnetic simulation of the transmitter geometry. Simple approximate relations are also given to estimate coupled energy from the power. The effect of additional loads in the form of attached leads, forming transmission lines, are considered. The results are summarized in a set of susceptibility-type curves. Finally, we also consider drives to the cables themselves and the resulting common-to-differential mode currents in the load.

  15. Protein distributions from a stochastic model of the lac operon of E. coli with DNA looping: analytical solution and comparison with experiments.

    PubMed

    Choudhary, Krishna; Oehler, Stefan; Narang, Atul

    2014-01-01

    Although noisy gene expression is widely accepted, its mechanisms are subjects of debate, stimulated largely by single-molecule experiments. This work is concerned with one such study, in which Choi et al., 2008, obtained real-time data and distributions of Lac permease in E. coli. They observed small and large protein bursts in strains with and without auxiliary operators. They also estimated the size and frequency of these bursts, but these were based on a stochastic model of a constitutive promoter. Here, we formulate and solve a stochastic model accounting for the existence of auxiliary operators and DNA loops. We find that DNA loop formation is so fast that small bursts are averaged out, making it impossible to extract their size and frequency from the data. In contrast, we can extract not only the size and frequency of the large bursts, but also the fraction of proteins derived from them. Finally, the proteins follow not the negative binomial distribution, but a mixture of two distributions, which reflect the existence of proteins derived from small and large bursts.

  16. The Projectile Inside the Loop

    ERIC Educational Resources Information Center

    Varieschi, Gabriele U.

    2006-01-01

    The loop-the-loop demonstration can be easily adapted to study the kinematics of projectile motion, when the moving body falls inside the apparatus. Video capturing software can be used to reveal peculiar geometrical effects of this simple but educational experiment.

  17. Variables Affecting Smooth Particle Hydrodynamics Simulation of High-Velocity Flyer Plate Impact Experiments

    SciTech Connect

    Somasundaram, Deepak S; Trabia, Mohamed; O'Toole, Brendan; Hixson, Robert S

    2014-01-23

    This paper describes our work to characterize the variables affecting the smoothed particle hydrodynamics (SPH) method in the LS-DYNA package for simulating high-velocity flyer plate impact experiments. LS-DYNA simulations are compared with one-dimensional experimental data of an oxygen-free high-conductivity (OFHC) copper flyer plate impacting another plate of the same material. The comparison is made by measuring the velocity of a point on the back surface of the impact plate using the velocity interferometer system for any reflector (VISAR) technique.

  18. The Dynamical Response of Dark Matter to Galaxy Evolution Affects Direct-Detection Experiments

    NASA Astrophysics Data System (ADS)

    Petersen, Michael; Katz, Neal; Weinberg, Martin

    2017-01-01

    Over a handful of rotation periods, dynamical processes in barred galaxies induce non-axisymmetric structure in dark matter halos. Using n-body simulations of a Milky Way-like barred galaxy, we identify both a trapped dark-matter component, a shadow bar, and a strong response wake in the dark-matter distribution that affects the predicted dark-matter detection rates for current and future experiments. We find that the magnitude of the combined stellar and shadow bar evolution makes a 30% increase in disk-plane density. This is significantly larger that of previously claimed deviations from the standard halo model. The dark-matter density and kinematic wakes driven by the Milky Way bar increase the detectability of dark matter overall, especially for the experiments with higher minimum velocities. These astrophysical features increase the detection rate by more than a factor of two when compared to the standard halo model and by a factor of ten for experiments with high minimum recoil energy thresholds. These same features increase (decrease) the annual modulation for low (high) minimum recoil energy experiments. We present physical arguments for why these dynamics are generic for barred galaxies such as the Milky Way rather than contingent on a specific galaxy model.

  19. Combining Charge Couple Devices and Rate Sensors for the Feedforward Control System of a Charge Coupled Device Tracking Loop

    PubMed Central

    Tang, Tao; Tian, Jing; Zhong, Daijun; Fu, Chengyu

    2016-01-01

    A rate feed forward control-based sensor fusion is proposed to improve the closed-loop performance for a charge couple device (CCD) tracking loop. The target trajectory is recovered by combining line of sight (LOS) errors from the CCD and the angular rate from a fiber-optic gyroscope (FOG). A Kalman filter based on the Singer acceleration model utilizes the reconstructive target trajectory to estimate the target velocity. Different from classical feed forward control, additive feedback loops are inevitably added to the original control loops due to the fact some closed-loop information is used. The transfer function of the Kalman filter in the frequency domain is built for analyzing the closed loop stability. The bandwidth of the Kalman filter is the major factor affecting the control stability and close-loop performance. Both simulations and experiments are provided to demonstrate the benefits of the proposed algorithm. PMID:27347970

  20. Pulling Rank: Military Rank Affects Hormone Levels and Fairness in an Allocation Experiment

    PubMed Central

    Siart, Benjamin; Pflüger, Lena S.; Wallner, Bernard

    2016-01-01

    Status within social hierarchies has great effects on the lives of socially organized mammals. Its effects on human behavior and related physiology, however, is relatively little studied. The present study investigated the impact of military rank on fairness and behavior in relation to salivary cortisol (C) and testosterone (T) levels in male soldiers. For this purpose 180 members of the Austrian Armed Forces belonging to two distinct rank groups participated in two variations of a computer-based guard duty allocation experiment. The rank groups were (1) warrant officers (high rank, HR) and (2) enlisted men (low rank, LR). One soldier from each rank group participated in every experiment. At the beginning of the experiment, one participant was assigned to start standing guard and the other participant at rest. The participant who started at rest could choose if and when to relieve his fellow soldier and therefore had control over the experiment. In order to trigger perception of unfair behavior, an additional experiment was conducted which was manipulated by the experimenter. In the manipulated version both soldiers started in the standing guard position and were never relieved, believing that their opponent was at rest, not relieving them. Our aim was to test whether unfair behavior causes a physiological reaction. Saliva samples for hormone analysis were collected at regular intervals throughout the experiment. We found that in the un-manipulated setup high-ranking soldiers spent less time standing guard than lower ranking individuals. Rank was a significant predictor for C but not for T levels during the experiment. C levels in the HR group were higher than in the LR group. C levels were also elevated in the manipulated experiment compared to the un-manipulated experiment, especially in LR. We assume that the elevated C levels in HR were caused by HR feeling their status challenged by the situation of having to negotiate with an individual of lower military rank

  1. Pulling Rank: Military Rank Affects Hormone Levels and Fairness in an Allocation Experiment.

    PubMed

    Siart, Benjamin; Pflüger, Lena S; Wallner, Bernard

    2016-01-01

    Status within social hierarchies has great effects on the lives of socially organized mammals. Its effects on human behavior and related physiology, however, is relatively little studied. The present study investigated the impact of military rank on fairness and behavior in relation to salivary cortisol (C) and testosterone (T) levels in male soldiers. For this purpose 180 members of the Austrian Armed Forces belonging to two distinct rank groups participated in two variations of a computer-based guard duty allocation experiment. The rank groups were (1) warrant officers (high rank, HR) and (2) enlisted men (low rank, LR). One soldier from each rank group participated in every experiment. At the beginning of the experiment, one participant was assigned to start standing guard and the other participant at rest. The participant who started at rest could choose if and when to relieve his fellow soldier and therefore had control over the experiment. In order to trigger perception of unfair behavior, an additional experiment was conducted which was manipulated by the experimenter. In the manipulated version both soldiers started in the standing guard position and were never relieved, believing that their opponent was at rest, not relieving them. Our aim was to test whether unfair behavior causes a physiological reaction. Saliva samples for hormone analysis were collected at regular intervals throughout the experiment. We found that in the un-manipulated setup high-ranking soldiers spent less time standing guard than lower ranking individuals. Rank was a significant predictor for C but not for T levels during the experiment. C levels in the HR group were higher than in the LR group. C levels were also elevated in the manipulated experiment compared to the un-manipulated experiment, especially in LR. We assume that the elevated C levels in HR were caused by HR feeling their status challenged by the situation of having to negotiate with an individual of lower military rank

  2. Integrating cognitive and affective dimensions of pain experience into health professions education

    PubMed Central

    Murinson, Beth B; Mezei, Lina; Nenortas, Elizabeth

    2011-01-01

    Pain is prevalent in clinical settings, and yet it is relatively under-represented in the education of most students in the health professions. Because pain includes both sensory-discriminative and affective features, teaching students about pain presents unique challenges and opportunities. The present article describes the evolution of a new blueprint for clinical excellence that, among other competencies, incorporates a need for the emotional development of clinical trainees. The framework has been applied to the development and implementation of two new courses in pain. The first course is designed to provide a comprehensive foundation of medical knowledge regarding pain, while integratively introducing students to the affective dimensions of pain. The second course is designed to enhance students’ appreciation for the protean effects of pain through use of the humanities to represent medical experience. It is concluded that, to be most effective, fostering the emotional development of trainees in the health professions necessitates the incorporation of affect-focused learning objectives, educational tasks and assessment methods. PMID:22184551

  3. Characterization of the new AmpC β-lactamase FOX-8 reveals a single mutation, Phe313Leu, located in the R2 loop that affects ceftazidime hydrolysis.

    PubMed

    Pérez-Llarena, Francisco José; Kerff, Frédéric; Zamorano, Laura; Fernández, María Carmen; Nuñez, Maria Luz; Miró, Elisenda; Oliver, Antonio; Navarro, Ferran; Bou, Germán

    2013-10-01

    A novel class C β-lactamase (FOX-8) was isolated from a clinical strain of Escherichia coli. The FOX-8 enzyme possessed a unique substitution (Phe313Leu) compared to FOX-3. Isogenic E. coli strains carrying FOX-8 showed an 8-fold reduction in resistance to ceftazidime relative to FOX-3. In a kinetic analysis, FOX-8 displayed a 33-fold reduction in kcat/Km for ceftazidime compared to FOX-3. In the FOX family of β-lactamases, the Phe313 residue located in the R2 loop affects ceftazidime hydrolysis and alters the phenotype of E. coli strains carrying this variant.

  4. Wanting to maximize the positive and minimize the negative: implications for mixed affective experience in American and Chinese contexts.

    PubMed

    Sims, Tamara; Tsai, Jeanne L; Jiang, Da; Wang, Yaheng; Fung, Helene H; Zhang, Xiulan

    2015-08-01

    Previous studies have demonstrated that European Americans have fewer mixed affective experiences (i.e., are less likely to experience the bad with the good) compared with Chinese. In this article, we argue that these cultural differences are due to "ideal affect," or how people ideally want to feel. Specifically, we predict that people from individualistic cultures want to maximize positive and minimize negative affect more than people from collectivistic cultures, and as a result, they are less likely to actually experience mixed emotions (reflected by a more negative within-person correlation between actual positive and negative affect). We find support for this prediction in 2 experience sampling studies conducted in the United States and China (Studies 1 and 2). In addition, we demonstrate that ideal affect is a distinct construct from dialectical view of the self, which has also been related to mixed affective experience (Study 3). Finally, in Study 4, we demonstrate that experimentally manipulating the desire to maximize the positive and minimize the negative alters participants' actual experience of mixed emotions during a pleasant (but not unpleasant or combined pleasant and unpleasant) TV clip in the United States and Hong Kong. Together, these findings suggest that across cultures, how people want to feel shapes how they actually feel, particularly people's experiences of mixed affect.

  5. Wanting to Maximize the Positive and Minimize the Negative: Implications for Mixed Affective Experience in American and Chinese Contexts

    PubMed Central

    Sims, Tamara; Tsai, Jeanne L.; Jiang, Da; Wang, Yaheng; Fung, Helene H.; Zhang, Xiulan

    2016-01-01

    Previous studies have demonstrated that European Americans have fewer mixed affective experiences (i.e., are less likely to experience the bad with the good) compared to Chinese. In this paper, we argue that these cultural differences are due to “ideal affect,” or how people ideally want to feel. Specifically, we predict that people from individualistic cultures want to maximize positive and minimize negative affect more than people from collectivistic cultures, and as a result, they are less likely to actually experience mixed emotions (reflected by a more negative within-person correlation between actual positive and negative affect). We find support for this prediction in two experience sampling studies conducted in the U.S. and China (Studies 1 and 2). In addition, we demonstrate that ideal affect is a distinct construct from dialectical view of the self, which has also been related to mixed affective experience (Study 3). Finally, in Study 4, we demonstrate that experimentally manipulating the desire to maximize the positive and minimize the negative alters participants' actual experience of mixed emotions during a pleasant (but not unpleasant or combined pleasant and unpleasant) television clip in the U.S. and Hong Kong. Together, these findings suggest that across cultures, how people want to feel shapes how they actually feel, particularly people's mixed affective experience. PMID:26121525

  6. Design and Performance Evaluation of a Dual Antenna Joint Carrier Tracking Loop

    PubMed Central

    Guo, Wenfei; Lin, Tao; Niu, Xiaoji; Shi, Chuang; Zhang, Hongping

    2015-01-01

    In order to track the carrier phases of Global Navigation Satellite Systems (GNSS) signals in signal degraded environments, a dual antenna joint carrier tracking loop is proposed and evaluated. This proposed tracking loop processes inputs from two antennas, namely the master antenna and the slave antenna. The master antenna captures signals in open-sky environments, while the slave antenna capture signals in degraded environments. In this architecture, a Phase Lock Loop (PLL) is adopted as a master loop to track the carrier phase of the open-sky signals. The Doppler frequency estimated by this master loop is utilized to assist weak carrier tracking in the slave loop. As both antennas experience similar signal dynamics due to satellite motion and clock frequency variations, a much narrower loop bandwidth and possibly a longer coherent integration can be adopted to track the weak signals in slave channels, by utilizing the Doppler aid from master channels. PLL tracking performance is affected by the satellite/user dynamics, clock instability, and thermal noise. In this paper, their impacts on the proposed phase tracking loop are analyzed and verified by both simulation and field data. Theoretical analysis and experimental results show that the proposed loop structure can track degraded signals (i.e., 18 dB-Hz) with a very narrow loop bandwidth (i.e., 0.5 Hz) and a TCXO clock. PMID:26437415

  7. Design and Performance Evaluation of a Dual Antenna Joint Carrier Tracking Loop.

    PubMed

    Guo, Wenfei; Lin, Tao; Niu, Xiaoji; Shi, Chuang; Zhang, Hongping

    2015-10-01

    In order to track the carrier phases of Global Navigation Satellite Systems (GNSS) signals in signal degraded environments, a dual antenna joint carrier tracking loop is proposed and evaluated. This proposed tracking loop processes inputs from two antennas, namely the master antenna and the slave antenna. The master antenna captures signals in open-sky environments, while the slave antenna capture signals in degraded environments. In this architecture, a Phase Lock Loop (PLL) is adopted as a master loop to track the carrier phase of the open-sky signals. The Doppler frequency estimated by this master loop is utilized to assist weak carrier tracking in the slave loop. As both antennas experience similar signal dynamics due to satellite motion and clock frequency variations, a much narrower loop bandwidth and possibly a longer coherent integration can be adopted to track the weak signals in slave channels, by utilizing the Doppler aid from master channels. PLL tracking performance is affected by the satellite/user dynamics, clock instability, and thermal noise. In this paper, their impacts on the proposed phase tracking loop are analyzed and verified by both simulation and field data. Theoretical analysis and experimental results show that the proposed loop structure can track degraded signals (i.e., 18 dB-Hz) with a very narrow loop bandwidth (i.e., 0.5 Hz) and a TCXO clock.

  8. In invisibility and isolation: the experience of HIV-affected families in German-speaking Switzerland.

    PubMed

    Spirig, Rebecca

    2002-12-01

    Based on critical hermeneutics, the author presents insights about caregiving experiences of HIV-affected families in Switzerland. Using a qualitative approach, she interviewed 11 families and conducted 3 group discussions with members of different families. Two main themes emerged--Caught In Between: Family Changes Forced by HIV/AIDS and No Request for Support: Family Caregiving in the Context of Invisibility. The former portrays the families' struggle with new family constellations. Members felt close to, ambivalent toward, or distant from the infected member and built subgroups representing these connections and values. The latter portrays the families' withdrawal from their environment, whereby one or two close family members almost invisibly provided caregiving without outside support. These behaviors were reinforced by the Swiss health care system, which focuses on individuals. Suggestions for interventions are introduced.

  9. The role of affective experience in work motivation: Test of a conceptual model

    PubMed Central

    SEO, MYEONG-GU; BARTUNEK, JEAN M.; BARRETT, LISA FELDMAN

    2011-01-01

    Summary The purpose of this paper was to contribute to understanding of the crucial role of emotion in work motivation by testing a conceptual model developed by Seo, Barrett, and Bartunek (2004) that predicted the impacts of core affect on three behavioral outcomes of work motivation, generative-defensive orientation, effort, and persistence. We tested the model using an Internet-based investment simulation combined with an experience sampling procedure. Consistent with the predictions of the model, pleasantness was positively related to all three of the predicted indices. For the most part, these effects occurred indirectly via its relationships with expectancy, valence, and progress judgment components. Also as predicted by the model, activation was directly and positively related to effort. PMID:21785527

  10. Loop Heat Pipe Startup Behaviors

    NASA Technical Reports Server (NTRS)

    Ku, Jentung

    2014-01-01

    A loop heat pipe must start successfully before it can commence its service. The start-up transient represents one of the most complex phenomena in the loop heat pipe operation. This paper discusses various aspects of loop heat pipe start-up behaviors. Topics include the four start-up scenarios, the initial fluid distribution between the evaporator and reservoir that determines the start-up scenario, factors that affect the fluid distribution between the evaporator and reservoir, difficulties encountered during the low power start-up, and methods to enhance the start-up success. Also addressed are the thermodynamic constraint between the evaporator and reservoir in the loop heat pipe operation, the superheat requirement for nucleate boiling, pressure spike and pressure surge during the start-up transient, and repeated cycles of loop start-up andshutdown under certain conditions.

  11. Human Empathy, Personality and Experience Affect the Emotion Ratings of Dog and Human Facial Expressions.

    PubMed

    Kujala, Miiamaaria V; Somppi, Sanni; Jokela, Markus; Vainio, Outi; Parkkonen, Lauri

    2017-01-01

    Facial expressions are important for humans in communicating emotions to the conspecifics and enhancing interpersonal understanding. Many muscles producing facial expressions in humans are also found in domestic dogs, but little is known about how humans perceive dog facial expressions, and which psychological factors influence people's perceptions. Here, we asked 34 observers to rate the valence, arousal, and the six basic emotions (happiness, sadness, surprise, disgust, fear, and anger/aggressiveness) from images of human and dog faces with Pleasant, Neutral and Threatening expressions. We investigated how the subjects' personality (the Big Five Inventory), empathy (Interpersonal Reactivity Index) and experience of dog behavior affect the ratings of dog and human faces. Ratings of both species followed similar general patterns: human subjects classified dog facial expressions from pleasant to threatening very similarly to human facial expressions. Subjects with higher emotional empathy evaluated Threatening faces of both species as more negative in valence and higher in anger/aggressiveness. More empathetic subjects also rated the happiness of Pleasant humans but not dogs higher, and they were quicker in their valence judgments of Pleasant human, Threatening human and Threatening dog faces. Experience with dogs correlated positively with ratings of Pleasant and Neutral dog faces. Personality also had a minor effect on the ratings of Pleasant and Neutral faces in both species. The results imply that humans perceive human and dog facial expression in a similar manner, and the perception of both species is influenced by psychological factors of the evaluators. Especially empathy affects both the speed and intensity of rating dogs' emotional facial expressions.

  12. Human Empathy, Personality and Experience Affect the Emotion Ratings of Dog and Human Facial Expressions

    PubMed Central

    Kujala, Miiamaaria V.; Somppi, Sanni; Jokela, Markus; Vainio, Outi; Parkkonen, Lauri

    2017-01-01

    Facial expressions are important for humans in communicating emotions to the conspecifics and enhancing interpersonal understanding. Many muscles producing facial expressions in humans are also found in domestic dogs, but little is known about how humans perceive dog facial expressions, and which psychological factors influence people’s perceptions. Here, we asked 34 observers to rate the valence, arousal, and the six basic emotions (happiness, sadness, surprise, disgust, fear, and anger/aggressiveness) from images of human and dog faces with Pleasant, Neutral and Threatening expressions. We investigated how the subjects’ personality (the Big Five Inventory), empathy (Interpersonal Reactivity Index) and experience of dog behavior affect the ratings of dog and human faces. Ratings of both species followed similar general patterns: human subjects classified dog facial expressions from pleasant to threatening very similarly to human facial expressions. Subjects with higher emotional empathy evaluated Threatening faces of both species as more negative in valence and higher in anger/aggressiveness. More empathetic subjects also rated the happiness of Pleasant humans but not dogs higher, and they were quicker in their valence judgments of Pleasant human, Threatening human and Threatening dog faces. Experience with dogs correlated positively with ratings of Pleasant and Neutral dog faces. Personality also had a minor effect on the ratings of Pleasant and Neutral faces in both species. The results imply that humans perceive human and dog facial expression in a similar manner, and the perception of both species is influenced by psychological factors of the evaluators. Especially empathy affects both the speed and intensity of rating dogs’ emotional facial expressions. PMID:28114335

  13. Increased temperatures negatively affect Juniperus communis seeds: evidence from transplant experiments along a latitudinal gradient.

    PubMed

    Gruwez, R; De Frenne, P; Vander Mijnsbrugge, K; Vangansbeke, P; Verheyen, K

    2016-05-01

    With a distribution range that covers most of the Northern hemisphere, common juniper (Juniperus communis) has one of the largest ranges of all vascular plant species. In several regions in Europe, however, populations are decreasing in size and number due to failing recruitment. One of the main causes for this failure is low seed viability. Observational evidence suggests that this is partly induced by climate warming, but our mechanistic understanding of this effect remains incomplete. Here, we experimentally assess the influence of temperature on two key developmental phases during sexual reproduction, i.e. gametogenesis and fertilisation (seed phase two, SP2) and embryo development (seed phase three, SP3). Along a latitudinal gradient from southern France to central Sweden, we installed a transplant experiment with shrubs originating from Belgium, a region with unusually low juniper seed viability. Seeds of both seed phases were sampled during three consecutive years, and seed viability assessed. Warming temperatures negatively affected the seed viability of both SP2 and SP3 seeds along the latitudinal gradient. Interestingly, the effect on embryo development (SP3) only occurred in the third year, i.e. when the gametogenesis and fertilisation also took place in warmer conditions. We found strong indications that this negative influence mostly acts via disrupting growth of the pollen tube, the development of the female gametophyte and fertilisation (SP2). This, in turn, can lead to failing embryo development, for example, due to nutritional problems. Our results confirm that climate warming can negatively affect seed viability of juniper.

  14. Early experience affects the strength of vigilance for threat in rhesus monkey infants

    PubMed Central

    Mandalaywala, Tara M.; Parker, Karen J.; Maestripieri, Dario

    2014-01-01

    Both human and nonhuman primates exhibit a cognitive bias to social threat, but little is known about how this bias develops. We investigated the development of threat bias in free-ranging infant rhesus macaques (Macaca mulatta) at 3 (N = 45) and 9 (N = 46) months of age. Three-month-old infant monkeys did not display bias, but 9-month-olds exhibited increased maintenance of attention to threatening social stimuli (vigilance for threat). To examine whether the social environment affected vigilance for threat, behavioral data on maternal rank and protectiveness were collected across the first 12 weeks of life for infants tested at 9 months. Nine-month-old infants of high-ranking mothers and more protective mothers displayed greater vigilance for threat than infants of lower-ranking and less protective mothers. These results demonstrate that infant social cognition is malleable and shaped by mothers both directly (protectiveness) and indirectly (rank), as maternal characteristics affect infants’ social experiences. PMID:25125426

  15. Seagrasses are negatively affected by organic matter loading and Arenicola marina activity in a laboratory experiment.

    PubMed

    Govers, Laura L; Pieck, Timon; Bouma, Tjeerd J; Suykerbuyk, Wouter; Smolders, Alfons J P; van Katwijk, Marieke M

    2014-06-01

    When two ecosystem engineers share the same natural environment, the outcome of their interaction will be unclear if they have contrasting habitat-modifying effects (e.g., sediment stabilization vs. sediment destabilization). The outcome of the interaction may depend on local environmental conditions such as season or sediment type, which may affect the extent and type of habitat modification by the ecosystem engineers involved. We mechanistically studied the interaction between the sediment-stabilizing seagrass Zostera noltii and the bioturbating and sediment-destabilizing lugworm Arenicola marina, which sometimes co-occur for prolonged periods. We investigated (1) if the negative sediment destabilization effect of A. marina on Z. noltii might be counteracted by positive biogeochemical effects of bioirrigation (burrow flushing) by A. marina in sulfide-rich sediments, and (2) if previously observed nutrient release by A. marina bioirrigation could affect seagrasses. We tested the individual and combined effects of A. marina presence and high porewater sulfide concentrations (induced by organic matter addition) on seagrass biomass in a full factorial lab experiment. Contrary to our expectations, we did not find an effect of A. marina on porewater sulfide concentrations. A. marina activities affected the seagrass physically as well as by pumping nutrients, mainly ammonium and phosphate, from the porewater to the surface water, which promoted epiphyte growth on seagrass leaves in our experimental set-up. We conclude that A. marina bioirrigation did not alleviate sulfide stress to seagrasses. Instead, we found synergistic negative effects of the presence of A. marina and high sediment sulfide levels on seagrass biomass.

  16. Experience Sampling-Based Personalized Feedback and Positive Affect: A Randomized Controlled Trial in Depressed Patients

    PubMed Central

    Hartmann, Jessica A.; Wichers, Marieke; Menne-Lothmann, Claudia; Kramer, Ingrid; Viechtbauer, Wolfgang; Peeters, Frenk; Schruers, Koen R. J.; van Bemmel, Alex L.; Myin-Germeys, Inez; Delespaul, Philippe; van Os, Jim; Simons, Claudia J. P.

    2015-01-01

    Objectives Positive affect (PA) plays a crucial role in the development, course, and recovery of depression. Recently, we showed that a therapeutic application of the experience sampling method (ESM), consisting of feedback focusing on PA in daily life, was associated with a decrease in depressive symptoms. The present study investigated whether the experience of PA increased during the course of this intervention. Design Multicentre parallel randomized controlled trial. An electronic random sequence generator was used to allocate treatments. Settings University, two local mental health care institutions, one local hospital. Participants 102 pharmacologically treated outpatients with a DSM-IV diagnosis of major depressive disorder, randomized over three treatment arms. Intervention Six weeks of ESM self-monitoring combined with weekly PA-focused feedback sessions (experimental group); six weeks of ESM self-monitoring combined with six weekly sessions without feedback (pseudo-experimental group); or treatment as usual (control group). Main outcome The interaction between treatment allocation and time in predicting positive and negative affect (NA) was investigated in multilevel regression models. Results 102 patients were randomized (mean age 48.0, SD 10.2) of which 81 finished the entire study protocol. All 102 patients were included in the analyses. The experimental group did not show a significant larger increase in momentary PA during or shortly after the intervention compared to the pseudo-experimental or control groups (χ2 (2) =0.33, p=.846). The pseudo-experimental group showed a larger decrease in NA compared to the control group (χ2 (1) =6.29, p=.012). Conclusion PA-focused feedback did not significantly impact daily life PA during or shortly after the intervention. As the previously reported reduction in depressive symptoms associated with the feedback unveiled itself only after weeks, it is conceivable that the effects on daily life PA also evolve

  17. Training experience in gestures affects the display of social gaze in baboons' communication with a human.

    PubMed

    Bourjade, Marie; Canteloup, Charlotte; Meguerditchian, Adrien; Vauclair, Jacques; Gaunet, Florence

    2015-01-01

    Gaze behaviour, notably the alternation of gaze between distal objects and social partners that accompanies primates' gestural communication is considered a standard indicator of intentionality. However, the developmental precursors of gaze behaviour in primates' communication are not well understood. Here, we capitalized on the training in gestures dispensed to olive baboons (Papio anubis) as a way of manipulating individual communicative experience with humans. We aimed to delineate the effects of such a training experience on gaze behaviour displayed by the monkeys in relation with gestural requests. Using a food-requesting paradigm, we compared subjects trained in requesting gestures (i.e. trained subjects) to naïve subjects (i.e. control subjects) for their occurrences of (1) gaze behaviour, (2) requesting gestures and (3) temporal combination of gaze alternation with gestures. We found that training did not affect the frequencies of looking at the human's face, looking at food or alternating gaze. Hence, social gaze behaviour occurs independently from the amount of communicative experience with humans. However, trained baboons-gesturing more than control subjects-exhibited most gaze alternation combined with gestures, whereas control baboons did not. By reinforcing the display of gaze alternation along with gestures, we suggest that training may have served to enhance the communicative function of hand gestures. Finally, this study brings the first quantitative report of monkeys producing requesting gestures without explicit training by humans (controls). These results may open a window on the developmental mechanisms (i.e. incidental learning vs. training) underpinning gestural intentional communication in primates.

  18. A magnetic pulse does not affect homing pigeon navigation: a GPS tracking experiment.

    PubMed

    Holland, Richard; Filannino, Caterina; Gagliardo, Anna

    2013-06-15

    The cues by which homing pigeons are able to return to a home loft after displacement to unfamiliar release sites remain debated. A number of experiments in which migratory birds have been treated with a magnetic pulse have produced a disruption in their orientation, which argues that a ferrimagnetic sense is used for navigation in birds. One previous experiment has also indicated an effect of magnetic pulses on homing pigeon navigation, although with inconsistent results. Previous studies have shown that some magnetic-related information is transmitted by the trigeminal nerve to the brain in some bird species, including the homing pigeon. The function of this information is still unclear. It has been suggested that this information is important for navigation. Previous studies with trigeminal nerve lesioned homing pigeons have clearly shown that the lack of trigeminally mediated information, even if magnetic, is not crucial for homing performance. However, this result does not completely exclude the possibility that other ferrimagnetic receptors in the homing pigeon play a role in navigation. Additionally, recent studies on homing pigeons suggested the existence of a ferrimagnetic sense in a novel location presumably located in the inner ear (lagena). In the present study, we tested whether any ferrimagnetic magnetoreceptors, irrespective of their location in the bird's head, are involved in pigeons' homing. To do this, we treated homing pigeons with a strong magnetic pulse before release, tracked birds with GPS loggers and analyzed whether this treatment affected homing performance. In the single previous magnetic pulse experiment on homing pigeons, only initial orientation at a release site was considered and the results were inconsistent. We observed no effect of the magnetic pulse at any of the sites used on initial orientation, homing performance, tortuosity or track efficiency, which does not support a role for the ferrimagnetic sense in homing pigeon

  19. Perch compliance and experience affect destination choice of brown tree snakes (Boiga irregularis).

    PubMed

    Mauro, A Alexander; Jayne, C Bruce

    2016-04-01

    Arboreal animals often encounter branches with variable diameters that are highly correlated with stiffness, but how surface compliance affects the perch choice of animals is poorly understood. We used artificial branches to test the effects of different diameters and compliance on the choice between two destinations for twenty brown tree snakes as they bridged gaps. When both destinations were rigid, the diameters of the surfaces did not affect perch choice. However, with increased experience snakes developed a preference for a rigid, large-diameter perch compared to a compliant, small-diameter perch that collapsed under loads that were a small fraction of the weight of the snake. In hundreds of trials, with only one exception, the snakes proceeded to crawl entirely onto all rigid perches after first touching them, whereas the snakes commonly withdrew from the compliant perch even after touching it so lightly that it did not collapse. Hence, both tactile and visual cues appear to influence how these animals select a destination while crossing a gap. The preference for the rigid, large-diameter perch compared to the compliant, small-diameter perch developed mainly from short-term learning during three successive trials per testing session per individual. Furthermore, a preference for large diameters did not persist in the final treatment which used a rigid, large-diameter perch and a rigid, small-diameter perch. Hence, brown tree snakes appeared to be able to form short-term associations between the perch appearance and stiffness, the latter of which may have been determined via tactile sensory input.

  20. Negative Experiences in Physical Education and Sport: How Much Do They Affect Physical Activity Participation Later in Life?

    ERIC Educational Resources Information Center

    Cardinal, Bradley J.; Yan, Zi; Cardinal, Marita K.

    2013-01-01

    People's feelings toward physical activity are often influenced by memories of their childhood experiences in physical education and sport. Unfortunately, many adults remember negative experiences, which may affect their desire to maintain a physically active lifestyle. A survey that asked 293 students about recollections from their childhood…

  1. The poplar basic helix-loop-helix transcription factor BEE3 - Like gene affects biomass production by enhancing proliferation of xylem cells in poplar.

    PubMed

    Noh, Seol Ah; Choi, Young-Im; Cho, Jin-Seong; Lee, Hyoshin

    2015-06-19

    Brassinosteroids (BRs) play important roles in many aspects of plant growth and development, including regulation of vascular cambium activities and cell elongation. BR-induced BEE3 (brassinosteroid enhanced expression 3) is required for a proper BR response. Here, we identified a poplar (Populus alba × Populus glandulosa) BEE3-like gene, PagBEE3L, encoding a putative basic helix-loop-helix (bHLH)-type transcription factor. Expression of PagBEE3L was induced by brassinolide (BL). Transcripts of PagBEE3L were mainly detected in stems, with the internode having a low level of transcription and the node having a relatively higher level. The function of the PagBEE3L gene was investigated through phenotypic analyses with PagBEE3L-overexpressing (ox) transgenic lines. This work particularly focused on a potential role of PagBEE3L in stem growth and development of polar. The PagBEE3L-ox poplar showed thicker and longer stems than wild-type plants. The xylem cells from the stems of PagBEE3L-ox plants revealed remarkably enhanced proliferation, resulting in an earlier thickening growth than wild-type plants. Therefore, this work suggests that xylem development of poplar is accelerated in PagBEE3L-ox plants and PagBEE3L plays a role in stem growth by increasing the proliferation of xylem cells to promote the initial thickening growth of poplar stems.

  2. The poplar basic helix-loop-helix transcription factor BEE3 – Like gene affects biomass production by enhancing proliferation of xylem cells in poplar

    SciTech Connect

    Noh, Seol Ah Choi, Young-Im Cho, Jin-Seong Lee, Hyoshin

    2015-06-19

    Brassinosteroids (BRs) play important roles in many aspects of plant growth and development, including regulation of vascular cambium activities and cell elongation. BR-induced BEE3 (brassinosteroid enhanced expression 3) is required for a proper BR response. Here, we identified a poplar (Populus alba × Populus glandulosa) BEE3-like gene, PagBEE3L, encoding a putative basic helix-loop-helix (bHLH)-type transcription factor. Expression of PagBEE3L was induced by brassinolide (BL). Transcripts of PagBEE3L were mainly detected in stems, with the internode having a low level of transcription and the node having a relatively higher level. The function of the PagBEE3L gene was investigated through phenotypic analyses with PagBEE3L-overexpressing (ox) transgenic lines. This work particularly focused on a potential role of PagBEE3L in stem growth and development of polar. The PagBEE3L-ox poplar showed thicker and longer stems than wild-type plants. The xylem cells from the stems of PagBEE3L-ox plants revealed remarkably enhanced proliferation, resulting in an earlier thickening growth than wild-type plants. Therefore, this work suggests that xylem development of poplar is accelerated in PagBEE3L-ox plants and PagBEE3L plays a role in stem growth by increasing the proliferation of xylem cells to promote the initial thickening growth of poplar stems. - Highlights: • We identify the BEE3-like gene form hybrid poplar (Populus alba × Populus glandulosa). • We examine effects of overexpression of PagBEE3L on growth in poplar. • We found that 35S:BEE3L transgenic plants showed more rapid growth than wild-type plants. • BEE3L protein plays an important role in the development of plant stem.

  3. What 'really' affects health professions students' satisfaction with their educational experience? Implications for practice and research.

    PubMed

    El Ansari, Walid; Oskrochi, Reza

    2004-11-01

    Student satisfaction has been widely recognised as an indicator of the quality of the students' learning and teaching experience. The aim of the study was to explore the extent to which student satisfaction is influenced by 13 demographic- and educational-related variables. A cross-sectional survey was undertaken (18-item questionnaire, 1660 questionnaires). Principal component analysis categorised the 18 items into four learning and teaching dimensions. Each of the 13 variables was analysed for its influence on student satisfaction generally and on the four dimensions individually, before and after controlling for all the other variables. After controlling for all the variables, none of the demographic characteristics was associated with satisfaction. Most of the educational variables exercised their own independent and significant effects on general satisfaction and on satisfaction with the four individual dimensions. Collectively, decreased satisfaction was associated with being a pre registration, full-time student, usually with A level entry qualifications, attending term two modules whose assessment/s comprised combined strategies. Decreased satisfaction was also significantly associated with larger class sizes as regards the student numbers and with attaining lower grades in the assessments. The demographic variables were not as influential as the educational ones as regards the affects on students' satisfaction. The implications of the findings for research and practice are discussed.

  4. The Experience of Women Affected by Polycystic Ovary Syndrome: A Qualitative Study From Iran

    PubMed Central

    Nasiri Amiri, Fatemeh; Ramezani Tehrani, Fahimeh; Simbar, Masoumeh; Montazeri, Ali; Mohammadpour Thamtan, Reza Ali

    2014-01-01

    Background: Polycystic ovary syndrome (PCOS) is the most common chronic endocrine disorder. It has significant and diverse clinical consequences including reproductive, metabolic, and psychological morbidities as well as predisposition to malignancies. It is unclear how women with PCOS experience symptoms of this syndrome. Objectives: The aim of this study was to clarify the dimensions and components of quality of life in iranian women with PCOS. Patients and Methods: This study was a qualitative study to explore and document perceptions of women with PCOS about their disorder and quality of life. Semi-structured interviews with open ended questions were conducted with 23 women with PCOS. The interviews were continued to reach data saturation. The study was conducted in the Reproductive Endocrinology Research Center of Shahid Beheshti University of Medical Sciences. All the interviews were recorded and transcribed. Constant comparative analysis of the data was conducted manually according to the Strauss and Corbin analysis method. Results: The study revealed that the most important factors affecting quality of life in women with PCOS were the role functioning items as well as physical, mental, emotional, cognitive, and social dimensions. Conclusions: Comprehensive cares concerning various mental, emotional, cognitive, and social dimensions of quality of life should be planned for women with PCOS. PMID:24829583

  5. The experience of altered states of consciousness in shamanic ritual: the role of pre-existing beliefs and affective factors.

    PubMed

    Polito, Vince; Langdon, Robyn; Brown, Jac

    2010-12-01

    Much attention has been paid recently to the role of anomalous experiences in the aetiology of certain types of psychopathology, e.g. in the formation of delusions. We examine, instead, the top-down influence of pre-existing beliefs and affective factors in shaping an individual's characterisation of anomalous sensory experiences. Specifically we investigated the effects of paranormal beliefs and alexithymia in determining the intensity and quality of an altered state of consciousness (ASC). Fifty five participants took part in a sweat lodge ceremony, a traditional shamanic ritual which was unfamiliar to them. Participants reported significant alterations in their state of consciousness, quantified using the 'APZ' questionnaire, a standardized measure of ASC experience. Participants endorsing paranormal beliefs compatible with shamanic mythology, and those showing difficulty identifying feelings scored higher on positive dimensions of ASC experience. Our findings demonstrate that variation in an individual's characterisation of anomalous experiences is nuanced by pre-existing beliefs and affective factors.

  6. Life history affects how species experience succession in pen shell metacommunities.

    PubMed

    Munguia, Pablo

    2014-04-01

    In nature, very few species are common and broadly distributed. Most species are rare and occupy few sites; this pattern is ubiquitous across habitats and taxa. In spatially structured communities (metacommunities), regional distribution and local abundance may change as the relative effects of within-habitat processes (e.g., species interactions) and among-habitat processes (e.g., dispersal) may vary through succession. A field experiment with the marine benthic inhabitants of pen shells (Atrina rigida) tested how common and rare species respond to succession and metacommunity size. I followed community development through time and partitioned species into sessile and motile based on their natural history. Rare species drive diversity patterns and are influenced by metacommunity size: there are strong abundance-distribution differences between common and rare species in large metacommunities, but motile species show lower rates of change than sessile species. In small metacommunities both common and rare species have similar changes through time; the dichotomous distinction of common and rare species is not present. Edge effects in metacommunities affect species' changes in distribution and abundance. In large metacommunities diversity is higher in edge habitats relative to small metacommunities during early succession. However, edge effects benefit motile species over time in small metacommunities showing a rapid increase in diversity. Individual mobility is sensitive to regional community size and allows individuals to sort among different communities. In contrast, sessile species do not show this edge effect. Metacommunity theory is a useful framework for understanding spatially structured communities, but the natural history of coexisting species cannot be ignored.

  7. Water Stream "Loop-the-Loop"

    ERIC Educational Resources Information Center

    Jefimenko, Oleg

    1974-01-01

    Discusses the design of a modified loop-the-loop apparatus in which a water stream is used to illustrate centripetal forces and phenomena of high-velocity hydrodynamics. Included are some procedures of carrying out lecture demonstrations. (CC)

  8. The Effects of Prior Combat Experience on the Expression of Somatic and Affective Symptoms in Deploying Soldiers

    DTIC Science & Technology

    2006-01-01

    Journal of Psychosomatic ResThe effects of prior combat experience on the expression of somatic and affective symptoms in deploying soldiers William...theories of stress reaction, repression , and somatic amplification, combat- experienced soldiers reported limited affective complaints but greater...coping or repressive processes may be associated with selective amplification of somatic symptoms [11–13]. A number of studies suggest that exposure to

  9. Affective and Behavioural Variables: Reforms as Experiments to Produce a Civil Society

    ERIC Educational Resources Information Center

    Fitz-Gibbon, Carol T.

    2006-01-01

    Affective and behavioural indicators of the effects of schooling, and of other interventions, might be more important than cognitive indicators, particularly in the long run and considering the urgent need for civil societies. Examples are provided of the statistical properties of affective and behavioural indicators, and of their current use in…

  10. Pre-Instruction, Play-Teach-Play, Processing the Experience. The Three Little P's: Teaching Affective Skills in Physical Education

    ERIC Educational Resources Information Center

    Kuhrasch, Cindy

    2007-01-01

    Physical education has long been recognized as a forum through which affective skills can be successfully introduced and practiced. Solomon found that current research supports the contention that physical education experiences provide a prime setting for promoting character development. This article describes a three-phase program for teaching…

  11. Optical parametric loop mirror

    NASA Astrophysics Data System (ADS)

    Mori, K.; Morioka, T.; Saruwatari, M.

    1995-06-01

    A novel configuration for four-wave mixing (FWM) is proposed that offers the remarkable feature of inherently separating the FWM wave from the input pump and signal waves and suppressing their background amplified stimulated emission without optical filtering. In the proposed configuration, an optical parametric loop mirror, two counterpropagating FWM waves generated in a Sagnac interferometer interfere with a relative phase difference that is introduced deliberately. FWM frequency-conversion experiments in a polarization-maintaining fiber achieved more than 35 dB of input-wave suppression against the FWM wave.

  12. Starting Smart: How Early Experiences Affect Brain Development. An Ounce of Prevention Fund Paper.

    ERIC Educational Resources Information Center

    Ounce of Prevention Fund.

    Recent research has provided great insight into the impact of early experience on brain development. It is now believed that brain growth is highly dependent upon early experiences. Neurons allow communication and coordinated functioning among various brain areas. Brain development after birth consists of an ongoing process of wiring and rewiring…

  13. Description and experience: How experimental investors learn about booms and busts affects their financial risk taking.

    PubMed

    Lejarraga, Tomás; Woike, Jan K; Hertwig, Ralph

    2016-12-01

    A few years ago, the world experienced the most severe economic crisis since the Great Depression. According to the depression baby hypothesis, people who live through such macroeconomic shocks take less financial risk in their future lives (e.g., lower stock market participation). This hypothesis has previously been tested against survey data. Here, we tested it in a simulated experimental stock market (based on the Spanish stock index, IBEX-35), varying both the length of historical data available to participants (including or excluding a macroeconomic shock) and the mode of learning about macroeconomic events (through sequential experience or symbolic descriptions). Investors who learned about the market from personal experience took less financial risk than did those who learned from graphs, thus echoing the description-experience gap observed in risky choice. In a second experiment, we reversed the market, turning the crisis into a boom. The description-experience gap persisted, with investors who experienced the boom taking more risk than those who did not. The results of a third experiment suggest that the observed gap is not driven by a wealth effect, and modeling suggests that the description-experience gap is explained by the fact that participants who learn from experience are more risk averse after a negative shock. Our findings highlight the crucial role of the mode of learning for financial risk taking and, by extension, in the legally required provision of financial advice.

  14. Affective Pacman: A Frustrating Game for Brain-Computer Interface Experiments

    NASA Astrophysics Data System (ADS)

    Reuderink, Boris; Nijholt, Anton; Poel, Mannes

    We present the design and development of Affective Pacman, a game that induces frustration to study the effect of user state changes on the EEG signal. Affective Pacman is designed to induce frustration for short periods, and allows the synchronous recording of a wide range of sensors, such as physiological sensors and EEG in addition to the game state. A self-assessment is integrated in the game to track changes in user state. Preliminary results indicate a significant effect of the frustration induction on the EEG.

  15. Variables Affecting Pharmacy Students’ Patient Care Interventions during Advanced Pharmacy Practice Experiences

    PubMed Central

    Patterson, Brandon J.; Sen, Sanchita; Bingham, Angela L.; Bowen, Jane F.; Ereshefsky, Benjamin; Siemianowski, Laura A.

    2016-01-01

    Objective. To identify the temporal effect and factors associated with student pharmacist self-initiation of interventions during acute patient care advanced pharmacy practice experiences (APPE). Methods. During the APPE, student pharmacists at an academic medical center recorded their therapeutic interventions and who initiated the intervention throughout clinical rotations. At the end of the APPE student pharmacists completed a demographic survey. Results. Sixty-two student pharmacists were included. Factors associated with lower rates of self-initiated interventions were infectious diseases and pediatrics APPEs and an intention to pursue a postgraduate residency. Timing of the APPE, previous specialty elective course completion, and previous hospital experience did not result in any significant difference in self-initiated recommendations. Conclusion. Preceptors should not base practice experience expectations for self-initiated interventions on previous student experience or future intentions. Additionally, factors leading to lower rates of self-initiated interventions on infectious diseases or pediatrics APPEs should be explored. PMID:27756924

  16. Variables Affecting Pharmacy Students' Patient Care Interventions during Advanced Pharmacy Practice Experiences.

    PubMed

    Bio, Laura L; Patterson, Brandon J; Sen, Sanchita; Bingham, Angela L; Bowen, Jane F; Ereshefsky, Benjamin; Siemianowski, Laura A

    2016-09-25

    Objective. To identify the temporal effect and factors associated with student pharmacist self-initiation of interventions during acute patient care advanced pharmacy practice experiences (APPE). Methods. During the APPE, student pharmacists at an academic medical center recorded their therapeutic interventions and who initiated the intervention throughout clinical rotations. At the end of the APPE student pharmacists completed a demographic survey. Results. Sixty-two student pharmacists were included. Factors associated with lower rates of self-initiated interventions were infectious diseases and pediatrics APPEs and an intention to pursue a postgraduate residency. Timing of the APPE, previous specialty elective course completion, and previous hospital experience did not result in any significant difference in self-initiated recommendations. Conclusion. Preceptors should not base practice experience expectations for self-initiated interventions on previous student experience or future intentions. Additionally, factors leading to lower rates of self-initiated interventions on infectious diseases or pediatrics APPEs should be explored.

  17. Fast flux locked loop

    DOEpatents

    Ganther, Jr., Kenneth R.; Snapp, Lowell D.

    2002-09-10

    A flux locked loop for providing an electrical feedback signal, the flux locked loop employing radio-frequency components and technology to extend the flux modulation frequency and tracking loop bandwidth. The flux locked loop of the present invention has particularly useful application in read-out electronics for DC SQUID magnetic measurement systems, in which case the electrical signal output by the flux locked loop represents an unknown magnetic flux applied to the DC SQUID.

  18. The preprocessed doacross loop

    NASA Technical Reports Server (NTRS)

    Saltz, Joel H.; Mirchandaney, Ravi

    1990-01-01

    Dependencies between loop iterations cannot always be characterized during program compilation. Doacross loops typically make use of a-priori knowledge of inter-iteration dependencies to carry out required synchronizations. A type of doacross loop is proposed that allows the scheduling of iterations of a loop among processors without advance knowledge of inter-iteration dependencies. The method proposed for loop iterations requires that parallelizable preprocessing and postprocessing steps be carried out during program execution.

  19. OPE for super loops

    NASA Astrophysics Data System (ADS)

    Sever, Amit; Vieira, Pedro; Wang, Tianheng

    2011-11-01

    We extend the Operator Product Expansion for Null Polygon Wilson loops to the Mason-Skinner-Caron-Huot super loop dual to non MHV gluon amplitudes. We explain how the known tree level amplitudes can be promoted into an infinite amount of data at any loop order in the OPE picture. As an application, we re-derive all one loop NMHV six gluon amplitudes by promoting their tree level expressions. We also present some new all loops predictions for these amplitudes.

  20. Effects of Automobile Commute Characteristics on Affect and Job Candidate Evaluations: A Field Experiment

    ERIC Educational Resources Information Center

    Van Rooy, David L.

    2006-01-01

    The current study assesses the effects of the commuting environment on affective states and hiring decisions. A total of 136 undergraduate females were randomly assigned to one of four conditions based on the length (10 km vs. 30 km) and level of congestion (low vs. high) during a commute. Multivariate analyses of variance indicate that affective…

  1. A Sharing Experience: Development of a Group for Families Affected by HIV Infection.

    ERIC Educational Resources Information Center

    Melvin, Diane; Appleby, Sue

    1995-01-01

    Describes the establishment and development of a support group for the parents of children infected and/or affected by HIV infection. The group is hospital-based, meeting monthly since April 1992, facilitated by professionals but with a self-help and peer support emphasis. Explains the planning, setting, and running of the group. Identifies…

  2. Sexual experience affects reproductive behavior and preoptic androgen receptors in male mice

    PubMed Central

    Swaney, William T.; Dubose, Brittany N.; Curley, James P.; Champagne, Frances A.

    2012-01-01

    Reproductive behavior in male rodents is made up of anticipatory and consummatory elements which are regulated in the brain by sensory systems, reward circuits and hormone signaling. Gonadal steroids play a key role in the regulation of male sexual behavior via steroid receptors in the hypothalamus and preoptic area. Typical patterns of male reproductive behavior have been characterized, however these are not fixed but are modulated by adult experience. We assessed the effects of repeated sexual experience on male reproductive behavior of C57BL/6 mice; including measures of olfactory investigation of females, mounting, intromission and ejaculation. The effects of sexual experience on the number of cells expressing either androgen receptor (AR) or estrogen receptor alpha (ERα) in the primary brain nuclei regulating male sexual behavior was also measured. Sexually experienced male mice engaged in less sniffing of females before initiating sexual behavior and exhibited shorter latencies to mount and intromit, increased frequency of intromission, and increased duration of intromission relative to mounting. No changes in numbers of ERα-positive cells were observed, however sexually experienced males had increased numbers of AR-positive cells in the medial preoptic area (MPOA); the primary regulatory nucleus for male sexual behavior. These results indicate that sexual experience results in a qualitative change in male reproductive behavior in mice that is associated with increased testosterone sensitivity in the MPOA and that this nucleus may play a key integrative role in mediating the effects of sexual experience on male behavior. PMID:22266118

  3. An Experiment to Demonstrate How a Catalyst Affects the Rate of a Reaction

    NASA Astrophysics Data System (ADS)

    Copper, Christine L.; Koubek, Edward

    1999-12-01

    By performing this experiment, students in general and introductory physical chemistry can learn more about the effect of a catalyst on a chemical reaction. This experiment, which is a modified version of the traditional iodine clock reaction, allows students to calculate rates of reaction, orders of reactants, and activation energies. It also lets students discover that to increase a reaction's rate, a catalyst need only provide any additional pathway for the reaction, not necessarily a pathway having a lower activation energy. This experiment is designed so that students will notice that the amount of catalyst used is important. Furthermore, the slight amount (~10-5 M MoO42-) of catalyst needed to increase the overall reaction rate and the abrupt color change that occurs seem to pique the interest of our students.

  4. Experience of malaria in children of a flood affected area: a field hospital study.

    PubMed

    Afzal, M F; Sultan, M A

    2013-07-01

    ABSTRACT To determine the frequency of malaria among children presenting with fever in a flood affected area, and the frequency of Plasmodium vivax and P. falciparum among cases, this cross-sectional study was conducted from 1 September 2010 to 15 January 2011 in the Australian Field Camp and Ehsas Field Hospital, Kot Addu, Muzaffargarh District, Southern Punjab, Pakistan. Each febrile child aged < or = 15 years fulfilling the clinical case definition of suspected uncomplicated malaria was investigated by rapid diagnostic test. Of 20 288 children examined, 3198 (16%) febrile patients fulfilled the clinical case definition and 2406 (75%) cases were positive for malaria. P. vivax, P. falciparum, and co-infection were present in 1562 (65%), 759 (31%) and 85(4%) cases respectively. P. vivax was the most prevalent species followed by P. falciparum. Twenty seven (4%) cases of P. falciparum fulfilled the case definition of cerebral malaria. The age group most affected was 5-9 years (41%)

  5. Relationship of maternal and general self-acceptance to pre- and postpartum affective experience.

    PubMed

    Dimitrovsky, L; Lev, S; Itskowitz, R

    1998-09-01

    Forty-nine married primiparous Israeli women responded to W. W. K. Zung's (1965) Self-Rating Depression Scale, N. M. Bradburn's (1969) Affect Balance Scale, and measures of general and maternal self-acceptance during the last trimester of pregnancy and again 6 to 8 weeks following childbirth. There was a significant decrease in depression from pre- to postpartum for the total group. Women high in general self-acceptance were less depressed and displayed less negative affect than those low in general self-acceptance. There were no corresponding differences between the high and low maternal self-acceptance groups. Both pre- and postpartum women tended to rate themselves significantly higher for maternal self-acceptance than for general self-acceptance.

  6. Does Nursing Home Ownership Change Affect Family Ratings on Experience with Care?

    PubMed Central

    Li, Qinghua; Li, Yue

    2015-01-01

    Person-centeredness may suffer in NHs with recent ownership changes. This study identifies associations between ownership change and reported care experiences, important measures of person-centered care, for long-term residents in Maryland NHs. Care experience measures and ownership change data were collected from Maryland Health Care Commission reports, which reported data on 220 Maryland NHs from 2011–2012. Facility and market covariates were obtained from 2011 NH Compare and Area Health Resource Files. Linear regression was used to examine whether ownership change in 2011 was associated with lower care experience ratings reported during April–June 2012. Dependent variables were overall care rating (scale 1–10), percent of respondents answering that they would recommend the NH, and assessments of five care and resident life domains (scale 1–4). Care experiences reported in 2012 were high; however, after controlling for covariates, ownership change was associated with significant decreases in 6 out of 7 measures, including a 0.39-point decrease in overall care rating (P=0.001). NH managers and policymakers should consider strategies to improve patient-centeredness post-ownership change. PMID:26162057

  7. An Experiment To Demonstrate How a Catalyst Affects the Rate of a Reaction.

    ERIC Educational Resources Information Center

    Copper, Christine L.; Koubeck, Edward

    1999-01-01

    Describes a chemistry experiment that allows students to calculate rates of reaction, orders of reaction, and activation energies. The activity demonstrates that to increase a reaction's rate, a catalyst need only provide any additional pathway for the reaction, not necessarily a pathway having lower activation energy. (WRM)

  8. Institutional Characteristics Affecting the Educational Experiences of Undergraduate Students: A Review of Literature

    ERIC Educational Resources Information Center

    Lei, Simon A.

    2016-01-01

    Attending an undergraduate institution in the United States is one of the most exciting and unique experiences in college students' lives. Although students have only spent several years in college, it has strong impacts that may last a lifetime. Strong institutional commitment, through its investment and allocation of various resources, is a…

  9. Visual Data Collection Methods for Research on the Affective Dimensions of Children's Personal Experiences of PE

    ERIC Educational Resources Information Center

    Georgakis, Steve; Light, Richard

    2009-01-01

    The rapid growth of research on Teaching Games for Understanding (TGfU) over the past decade has paid little attention to research methodology. This paper redresses this lack of attention to research methods and reports on a study conducted on children's personal experiences of Game Sense. The study focuses on the use of year six students'…

  10. What Affects Willingness to Mentor in the Future? An Investigation of Attachment Styles and Mentoring Experiences

    ERIC Educational Resources Information Center

    Wang, Sheng; Noe, Raymond A.; Wang, Zhong-Ming; Greenberger, David B.

    2009-01-01

    This study examined the influence of attachment styles and mentoring experiences on willingness to mentor in the future in a formal mentoring program in China. For both mentors and proteges, avoidance and anxiety dimensions of attachment styles and their interaction had a significant influence on willingness to mentor in the future. Mentoring…

  11. Vasovagal Syncope and Blood Donor Return: Examination of the Role of Experience and Affective Expectancies

    ERIC Educational Resources Information Center

    Olatunji, Bunmi O.; Etzel, Erin N.; Ciesielski, Bethany G.

    2010-01-01

    Vasovagal sensations (e.g., dizziness, nausea, and fainting) are one of the main reasons people find blood donation unpleasant. A better understanding of predictors of vasovagal sensations during blood donation could inform interventions designed to increase donor return rates. The present investigation examined the extent to which experience with…

  12. Girls' and Boys' Mathematics Achievement, Affect, and Experiences: Findings from ECLS-K

    ERIC Educational Resources Information Center

    Lubienski, Sarah T.; Robinson, Joseph P.; Crane, Corinna C.; Ganley, Colleen M.

    2013-01-01

    Amid debates about the continued salience of gender in mathematics, this report summarizes an IES-funded investigation of gender-related patterns in the Early Childhood Longitudinal Study-Kindergarten Class of 1998-99 (ECLS-K). Girls' and boys' mathematics achievement, confidence, and interest were examined, along with experiences at home and…

  13. What Factors Affect the Separation of Substances Using Thin-Layer Chromatography? An Undergraduate Experiment.

    ERIC Educational Resources Information Center

    Nash, John J.; Meyer, Jeanne A.; Everson, Barbara

    2001-01-01

    Rx values in thin-layer chromatography (TLC) depend strongly on the solvent saturation of the atmosphere above the liquid in the TLC developing chamber. Presents an experiment illustrating the potentially dramatic effects on TLC Rx values of not equilibrating the solvent atmosphere during development. (ASK)

  14. Does Nursing Home Ownership Change Affect Family Ratings on Experience with Care?

    PubMed

    Campbell, Lauren J; Li, Qinghua; Li, Yue

    2015-01-01

    Person-centeredness may suffer in nursing homes (NHs) with recent ownership changes. This study identifies associations between ownership change and reported care experiences, important measures of person-centered care for long-term residents in Maryland NHs. Care experience measures and ownership change data were collected from Maryland Health Care Commission reports, which reported data on 220 Maryland NHs from 2011 and 2012. Facility and market covariates were obtained from 2011 NH Compare and Area Health Resource Files. Linear regression was used to examine whether ownership change in 2011 was associated with lower care experience ratings reported during April to June 2012. Dependent variables were overall care rating (scale 1-10), percentage of respondents answering that they would recommend the NH, and assessments of five care and resident life domains (scale 1-4). Care experiences reported in 2012 were high; however, after controlling for covariates, ownership change was associated with significant decreases in 6 out of 7 measures, including a 0.39-point decrease in overall care rating (p = .001). NH managers and policy makers should consider strategies to improve patient-centeredness after ownership change.

  15. Factors Affecting Spatial Test Performance: Sex, Handedness, Birth Order, and Experience.

    ERIC Educational Resources Information Center

    Guay, Roland B.

    Four factors have been reported in the literature as being related to spatial test performance. This study investigated the main and interaction effects of sex, handedness, birth order, and experience on three different types of spatial performance; surface development, object rotation, and coordination of viewpoints. A total of 217 undergraduate…

  16. "Doing Gender" at "Body Worlds": Embodying Field Trips as Affective Educational Experience

    ERIC Educational Resources Information Center

    Davidson, Joyce; Huff, Leah; Bridgen, Jen; Carolan, Andrea; Chang, Ashley; Ennis, Katherine; Loynes, Kathryn; Miller, Jen

    2009-01-01

    This paper discusses the background, experience and outcomes of an explicitly feminist field trip to Gunther von Hagen's "Body Worlds 2: The Anatomical Exhibition of Real Human Bodies". The cultural landscape of this exhibition materialized gendered geographies very powerfully, facilitating observation and analysis of embodied and emotional,…

  17. Do nursing home chain size and proprietary status affect experiences with care?

    PubMed Central

    You, Kai; Li, Yue; Intrator, Orna; Stevenson, David; Hirth, Richard; Grabowski, David; Banaszak-Holl, Jane

    2015-01-01

    Background In 2012, over half of nursing homes were operated by corporate chains. Facilities owned by the largest for-profit chains were reported to have lower quality of care. However, it is unknown how nursing home chain ownerships are related with experiences of care. Objectives To study the relationship between nursing home chain characteristics (chain size and profit status) with patients' family member reported ratings on experiences with care. Data Sources and Study Design Maryland nursing home care experience reports, the Online Survey, Certification, And Reporting (OSCAR) files, and Area Resource Files are used. Our sample consists of all non-governmental nursing homes in Maryland from 2007 to 2010. Consumer ratings were reported for: overall care; recommendation of the facility; staff performance; care provided; food and meals; physical environment; and autonomy and personal rights. We identified chain characteristics from OSCAR, and estimated multivariate random effect linear models to test the effects of chain ownership on care experience ratings. Results Independent nonprofit nursing homes have the highest overall rating score of 8.9, followed by 8.6 for facilities in small nonprofit chains, and 8.5 for independent for-profit facilities. Facilities in small, medium and large for-profit chains have even lower overall ratings of 8.2, 7.9, and 8.0, respectively. We find similar patterns of differences in terms of recommendation rate, and important areas such as staff communication and quality of care. Conclusions Evidence suggests that Maryland nursing homes affiliated with large- and medium- for-profit chains had lower ratings of family reported experience with care. PMID:26765147

  18. From Affective Experience to Motivated Action: Tracking Reward-Seeking and Punishment-Avoidant Behaviour in Real-Life

    PubMed Central

    Wichers, Marieke; Kasanova, Zuzana; Bakker, Jindra; Thiery, Evert; Derom, Catherine; Jacobs, Nele; van Os, Jim

    2015-01-01

    Many of the decisions and actions in everyday life result from implicit learning processes. Important to psychopathology are, for example, implicit reward-seeking and punishment-avoidant learning processes. It is known that when specific actions get associated with a rewarding experience, such as positive emotions, that this will increase the likelihood that an organism will engage in similar actions in the future. Similarly, when actions get associated with punishing experiences, such as negative emotions, this may reduce the likelihood that the organism will engage in similar actions in the future. This study examines whether we can observe these implicit processes prospectively in the flow of daily life. If such processes take place then we expect that current behaviour can be predicted by how similar behaviour was experienced (in terms of positive and negative affect) at previous measurement moments. This was examined in a sample of 621 female individuals that had participated in an Experience Sampling data collection. Measures of affect and behaviour were collected at 10 semi-random moments of the day for 5 consecutive days. It was examined whether affective experience that was paired with certain behaviours (physical activity and social context) at previous measurements modified the likelihood to show similar behaviours at next measurement moments. Analyses were performed both at the level of observations (a time scale with units of ± 90 min) and at day level (a time scale with units of 24 h). As expected, we found that affect indeed moderated the extent to which previous behaviour predicted similar behaviour later in time, at both beep- and day-level. This study showed that it is feasible to track reward-seeking and punishment-avoidant behaviour prospectively in humans in the flow of daily life. This opens up a new toolbox to examine processes determining goal-oriented behaviour in relation to psychopathology in humans. PMID:26087323

  19. From Affective Experience to Motivated Action: Tracking Reward-Seeking and Punishment-Avoidant Behaviour in Real-Life.

    PubMed

    Wichers, Marieke; Kasanova, Zuzana; Bakker, Jindra; Thiery, Evert; Derom, Catherine; Jacobs, Nele; van Os, Jim

    2015-01-01

    Many of the decisions and actions in everyday life result from implicit learning processes. Important to psychopathology are, for example, implicit reward-seeking and punishment-avoidant learning processes. It is known that when specific actions get associated with a rewarding experience, such as positive emotions, that this will increase the likelihood that an organism will engage in similar actions in the future. Similarly, when actions get associated with punishing experiences, such as negative emotions, this may reduce the likelihood that the organism will engage in similar actions in the future. This study examines whether we can observe these implicit processes prospectively in the flow of daily life. If such processes take place then we expect that current behaviour can be predicted by how similar behaviour was experienced (in terms of positive and negative affect) at previous measurement moments. This was examined in a sample of 621 female individuals that had participated in an Experience Sampling data collection. Measures of affect and behaviour were collected at 10 semi-random moments of the day for 5 consecutive days. It was examined whether affective experience that was paired with certain behaviours (physical activity and social context) at previous measurements modified the likelihood to show similar behaviours at next measurement moments. Analyses were performed both at the level of observations (a time scale with units of ± 90 min) and at day level (a time scale with units of 24 h). As expected, we found that affect indeed moderated the extent to which previous behaviour predicted similar behaviour later in time, at both beep- and day-level. This study showed that it is feasible to track reward-seeking and punishment-avoidant behaviour prospectively in humans in the flow of daily life. This opens up a new toolbox to examine processes determining goal-oriented behaviour in relation to psychopathology in humans.

  20. Adverse childhood experiences associate to reduced glutamate levels in the hippocampus of patients affected by mood disorders.

    PubMed

    Poletti, Sara; Locatelli, Clara; Falini, Andrea; Colombo, Cristina; Benedetti, Francesco

    2016-11-03

    Adverse childhood experiences (ACE) can possibly permanently alter the stress response system, affect the glutamatergic system and influence hippocampal volume in mood disorders. The aim of the study is to investigate the association between glutamate levels in the hippocampus, measured through single proton magnetic resonance spectroscopy (1H-MRS), and ACE in patients affected by mood disorders and healthy controls. Higher levels of early stress associate to reduced levels of Glx/Cr in the hippocampus in depressed patients but not in healthy controls. Exposure to stress during early life could lead to a hypofunctionality of the glutamatergic system in the hippocampus of depressed patients. Abnormalities of glutamatergic signaling could then possibly underpin the structural and functional abnormalities observed in patients affected by mood disorders.

  1. How Parents' Negative Experiences at Immunization Visits Affect Child Immunization Status in a Community in New York City

    PubMed Central

    Stockwell, Melissa S.; Irigoyen, Matilde; Martinez, Raquel Andres; Findley, Sally

    2011-01-01

    Objective Little is known about how families' experiences with immunization visits within the medical home may affect children's immunization status. We assessed the association between families' negative immunization experiences within the medical home and underimmunization. Methods We surveyed parents (n=392) of children aged 2–36 months about immunization experiences at community health centers, hospital-based clinics, private practices, and community-based organizations in New York City. We used Chi-square tests and odds ratios (ORs) to assess the relationship between medical home elements and parental immunization experience ratings. We used multivariable analysis to determine the association between negative experiences during immunization visits and underimmunization, controlling for insurance, maternal education, and receipt of benefits from the Special Supplemental Nutrition Program for Women, Infants, and Children. Results The majority of children were of Latino race/ethnicity and had Medicaid and a medical home. One-sixth (16.9%) of families reported a previous negative immunization experience, primarily related to the child's reaction, waiting time, and attitudes of medical and office staff. Parents' negative immunization experiences were associated with the absence of four components of the medical home: continuity of care, family-centered care, compassionate care, and comprehensive care. In addition, children in families who reported a negative experience were more likely to have been underimmunized (adjusted OR=2.00; 95% confidence interval 1.12, 3.58). Conclusions In a community in New York City, underimmunization of young children was associated with negative immunization experiences. Strategies to improve family experiences with immunization visits within the medical home (particularly around support for the family), medical and ancillary staff attitudes, and reduced waiting time may lead to improved immunization delivery. PMID:21812166

  2. Ancestry trumps experience: Transgenerational but not early life stress affects the adult physiological stress response.

    PubMed

    McCormick, Gail L; Robbins, Travis R; Cavigelli, Sonia A; Langkilde, Tracy

    2017-01-01

    Exposure to stressors can affect an organism's physiology and behavior as well as that of its descendants (e.g. through maternal effects, epigenetics, and/or selection). We examined the relative influence of early life vs. transgenerational stress exposure on adult stress physiology in a species that has populations with and without ancestral exposure to an invasive predator. We raised offspring of eastern fence lizards (Sceloporus undulatus) from sites historically invaded (high stress) or uninvaded (low stress) by predatory fire ants (Solenopsis invicta) and determined how this different transgenerational exposure to stress interacted with the effects of early life stress exposure to influence the physiological stress response in adulthood. Offspring from these high- and low-stress populations were exposed weekly to either sub-lethal attack by fire ants (an ecologically relevant stressor), topical treatment with a physiologically-appropriate dose of the stress-relevant hormone, corticosterone (CORT), or a control treatment from 2 to 43weeks of age. Several months after treatments ended, we quantified plasma CORT concentrations at baseline and following restraint, exposure to fire ants, and adrenocorticotropic hormone (ACTH) injection. Exposure to fire ants or CORT during early life did not affect lizard stress physiology in adulthood. However, offspring of lizards from populations that had experienced multiple generations of fire ant-invasion exhibited more robust adult CORT responses to restraint and ACTH-injection compared to offspring from uninvaded populations. Together, these results indicate that transgenerational stress history may be at least as important, if not more important, than early life stress in affecting adult physiological stress responses.

  3. Resident Involvement and Experience Do Not Affect Peri-Operative Complications Following Robotic Prostatectomy

    PubMed Central

    McMillan, Daniel T.; Viera, Anthony J.; Matthews, Jonathan; Raynor, Mathew C.; Woods, Michael E.; Pruthi, Raj S.; Wallen, Eric M.; Nielsen, Matthew E.; Smith, Angela B.

    2014-01-01

    Purpose Most urologic training programs use robotic prostatectomy (RP) as an introduction to teach residents appropriate robotic technique. However, concerns may exist regarding differences in RP outcomes with resident involvement. Our objective was therefore to evaluate whether resident involvement affects complications, operative time, or length of stay following RP. Methods Using the National Surgical Quality Improvement Program database (2005 – 2011), we identified patients who underwent RP, stratified them by resident presence or absence during surgery, and compared hospital length of stay (LOS), operative time, and postoperative complications using bivariable and multivariable analyses. A secondary analysis comparing outcomes of interest across postgraduate year (PGY) levels was also performed. Results 5,087 patients who underwent RPs were identified, in which residents participated in 56%, during the study period. After controlling for potential confounders, resident present and absent groups were similar in 30-day mortality (0.0% vs. 0.2%, p = 0.08), serious morbidity (1.8% vs. 2.1%, p = 0.33), and overall morbidity (5.1% vs. 5.4%, p = 0.70). While resident involvement did not affect LOS, operative time was longer when residents were present (median: 208 vs. 183 minutes, p < 0.001). Similar findings were noted when assessing individual PGY levels. Conclusions Regardless of PGY level, resident involvement in RPs appears safe and does not appear to affect postoperative complications or length of stay. While resident involvement in RPs does result in longer operative times, this is necessary for the learning process. PMID:24985554

  4. Mapping the urban asthma experience: Using qualitative GIS to understand contextual factors affecting asthma control.

    PubMed

    Keddem, Shimrit; Barg, Frances K; Glanz, Karen; Jackson, Tara; Green, Sarah; George, Maureen

    2015-09-01

    Asthma is complex and connected to a number of factors including access to healthcare, crime and violence, and environmental triggers. A mixed method approach was used to examine the experiences of urban people with asthma in controlling their asthma symptoms. The study started with an initial phase of qualitative interviews in West Philadelphia, a primarily poor African American community. Data from qualitative, semi-structured interviews indicated that stress, environmental irritants, and environmental allergens were the most salient triggers of asthma. Based on the interviews, the team identified six neighborhood factors to map including crime, housing vacancy, illegal dumping, tree canopy and parks. These map layers were combined into a final composite map. These combined methodologies contextualized respondents' perceptions in the framework of the actual community and built environment which tells a more complete story about their experience with asthma.

  5. Serious complications in experiments in which UV doses are affected by using different lamp heights

    NASA Astrophysics Data System (ADS)

    Flint, Stephan D.; Ryel, Ronald J.; Caldwell, Martyn M.

    2004-10-01

    Many experiments examining plant responses to enhanced UV-B radiation simply compare an enhanced UV-B radiation treatment with ambient UV-B (or no UV-B in most greenhouse and controlled environment studies). However, some experiments utilize multiple doses of UV-B radiation. A number of different techniques have been used to adjust the UV dose, each with advantages and disadvantages. One common technique is to place racks of fluorescent UV-B lamps at different heights above the plant canopy. A generally ignored consequence of this technique is that the pattern of shade which plants receive from the lamps is distributed differently over the course of the day at different lamp heights. To determine the effects of using lamps at different heights above the canopy, we grew three species (canola, sunflower, and maize) in the greenhouse under racks of unenergized lamps that were placed at two different heights above the plant canopy. Many plant growth characteristics differed between plants grown under the two lamp heights. These differences can potentially enhance or obscure true UV-B effects. Even more troubling is that changes in leaf mass per foliage area, which were observed in this experiment, could contribute to differences in plant UV-B sensitivity. We recommend the use of other techniques for achieving multiple doses of UV-B radiation. These range from simple and inexpensive approaches (wrapping individual fluorescent tubes in different layers of a neutral density filter such as cheese cloth) to more technical and expensive alternatives (electronically modulated lamp control systems). These choices should be determined by the goals of the particular experiment.

  6. Students’ Factors Affecting Undergraduates’ Perceptions of their Teaching and Learning Process within ECTS Experience

    PubMed Central

    la Fuente, Jesús De; Cardelle-Elawar, María; Peralta, F. Javier; Sánchez, M. Dolores; Martínez-Vicente, José Manuel; Zapata, Lucía

    2010-01-01

    Introduction: In the present study, we investigated the potential factors that influenced the level of students satisfaction with the teaching–learning process (TLP), from the perspective of students participating in the European Credit Transfer System (ECTS) experience. Method: A total of 1490 students from the Universities of Almería and Granada (Spain) participated in an evaluation of their class discipline area. They completed the new revised protocol for evaluating the ECTS experience. Analyses of variance were carried out, taking the following factors as independent variables: student's grade average, year in school, study discipline, credit load in terms of ECTS credits assigned to a subject, the e-learning approach. Perception of the TLP was used as the dependent variable. Results: The data analyses showed variability of the degree of statistically significance among the factors that influenced students’ perceptions of the TLP. These factors included: Student's grade average (in favor of high performers), year in school (in favor of earlier years), ECTS load (in favor of subjects with a medium load of credits), and e-learning (in favor of its use). These research findings provided evidence to explore the delineation of a potential profile of factors that trigger a favorable perception of the TLP. Discussion and Conclusion: The present findings certainly have implications to deepen our understanding of the core beliefs, commitment, and the experience in shaping the implementation of the European Higher Education Area through the ECTS. PMID:21713171

  7. Early-life experience affects honey bee aggression and resilience to immune challenge

    PubMed Central

    Rittschof, Clare C.; Coombs, Chelsey B.; Frazier, Maryann; Grozinger, Christina M.; Robinson, Gene E.

    2015-01-01

    Early-life social experiences cause lasting changes in behavior and health for a variety of animals including humans, but it is not well understood how social information ‘‘gets under the skin’’ resulting in these effects. Adult honey bees (Apis mellifera) exhibit socially coordinated collective nest defense, providing a model for social modulation of aggressive behavior. Here we report for the first time that a honey bee’s early-life social environment has lasting effects on individual aggression: bees that experienced high-aggression environments during pre-adult stages showed increased aggression when they reached adulthood relative to siblings that experienced low-aggression environments, even though all bees were kept in a common environment during adulthood. Unlike other animals including humans however, high-aggression honey bees were more, rather than less, resilient to immune challenge, assessed as neonicotinoid pesticide susceptibility. Moreover, aggression was negatively correlated with ectoparasitic mite presence. In honey bees, early-life social experience has broad effects, but increased aggression is decoupled from negative health outcomes. Because honey bees and humans share aspects of their physiological response to aggressive social encounters, our findings represent a step towards identifying ways to improve individual resiliency. Pre-adult social experience may be crucial to the health of the ecologically threatened honey bee. PMID:26493190

  8. Factors affecting the pore space transformation during hydrocarbon generation in source rock (shales): laboratory experiment

    NASA Astrophysics Data System (ADS)

    Giliazetdinova, D. R.; Korost, D. V.

    2014-12-01

    Oil and gas generation is a set of processes which taking place in the interior, the processes can't be observable in nature. In the process of dumping the source rock, organic matter is transformed into a complex of high-molecular compounds - precursors of oil and gas (kerogen). Entering of a source column for specific thermobaric conditions, triggers the formation of low molecular weight hydrocarbon compounds. Generation of sufficient quantities of hydrocarbons leads to the primary fluid migration within the source rock. For the experiment were selected mainly siliceous-carbonate composition rocks from Domanic horizon South-Tatar arch. The main aim of experiment was heating the rocks in the pyrolyzer to temperatures which correspond katagenes stages. For monitoring changes in the morphology of the pore space X-ray microtomography method was used. As a result, when was made a study of the composition of mineral and organic content of the rocks, as well as textural and structural features, have been identified that the majority of the rock samples within the selected collection are identical. However, characteristics such as organic content and texture of rocks are different. Thus, the experiment was divided into two parts: 1) the study of the influence of organic matter content on the morphology of the rock in the process of thermal effects; 2) study the effect of texture on the primary migration processes for the same values of organic matter. Also, an additional experiment was conducted to study the dynamics of changes in the structure of the pore space. At each stage of the experiment morphology of altered rocks characterized by the formation of new pores and channels connecting the primary voids. However, it was noted that the samples with a relatively low content of the organic matter had less changes in pore space morphology, in contrast to rocks with a high organic content. At the second stage of the research also revealed that the conversion of the pore

  9. Influence of Sex on Suicidal Phenotypes in Affective Disorder Patients with Traumatic Childhood Experiences

    PubMed Central

    Carlberg, Laura; Swoboda, Patrick; Ludwig, Birgit; Koller, Romina; Kapusta, Nestor D.; Aigner, Martin; Haslacher, Helmuth; Schmöger, Michaela; Kasper, Siegfried; Schosser, Alexandra

    2015-01-01

    Objectives In the current study, we aimed to investigate the impact of childhood trauma on suicidal behaviour phenotypes in a group of patients with diagnosed affective disorder (unipolar or bipolar affective disorder). Patients and Methods Patients with and without a history of childhood abuse, measured by Childhood Trauma Questionnaire (CTQ), were assessed to explore risks for suicidal behaviour (including suicide attempt, self-harm and non-suicidal self-injury). The tested sample consisted of 258 patients (111 males and 147 females, in-patients and out-patients at the Department of Psychiatry and Psychotherapy, Medical University of Vienna and University Hospital Tulln, Lower Austria). Psychiatric diagnoses were derived from the SCAN (Schedules for Clinical Assessment in Neuropsychiatry) interview. In addition, patients were administered the Lifetime Parasuicidal Count (LPC), Suicidal Behaviour Questionnaire (SBQ-R), and Viennese Suicide Risk Assessment Scale (VISURIAS) questionnaires. Results In contrast to male suicide attempters, female suicide attempters showed both significantly higher total CTQ scores (p<0.001), and higher CTQ subscores (emotional, physical and sexual abuse, as well as emotional and physical neglect) in comparison to the non-suicidal control group. Besides, females with a history of self-harming behaviour (including suicidal intention) and Non-Suicidal-Self Injury (NSSI) had significantly higher CTQ total scores (p<0.001) than the control group. Conclusion These findings suggest gender differences in suicidal behaviour after being exposed to childhood trauma. PMID:26366559

  10. Factors affecting student success in a first-year mathematics course: a South African experience

    NASA Astrophysics Data System (ADS)

    Kizito, Rita; Munyakazi, Justin; Basuayi, Clement

    2016-01-01

    In spite of sustained efforts tertiary institutions implement to try and improve student academic performance, the number of students succeeding in first-year mathematics courses remains disturbingly low. For most students, the gap between their mathematical capability and the competencies they are expected and need to develop to function effectively in these courses persists even after course instruction. In this study, an instrument for identifying and examining factors affecting student performance and success in a first-year Mathematics university course was developed and administered to 86 students. The overall Cronbach's Alpha coefficient for the questionnaire was found to be 0.916. Having identified variables from prior research known to affect student performance, factor analysis was used to identify variables exhibiting the greatest impact on student performance. The variables included prior academic knowledge, workload, student approaches to learning, assessment, student support teaching quality, methods and resources. From the analysis, students' perceptions of their workload emerged as the factor having the greatest impact on student's performance, followed by the matriculation examination score. The findings are discussed and strategies that can be used to improve teaching and contribute to student success in a first-year mathematics course in a South African context are presented.

  11. Spatial hearing in Cope's gray treefrog: I. Open and closed loop experiments on sound localization in the presence and absence of noise.

    PubMed

    Caldwell, Michael S; Bee, Mark A

    2014-04-01

    The ability to reliably locate sound sources is critical to anurans, which navigate acoustically complex breeding choruses when choosing mates. Yet, the factors influencing sound localization performance in frogs remain largely unexplored. We applied two complementary methodologies, open and closed loop playback trials, to identify influences on localization abilities in Cope's gray treefrog, Hyla chrysoscelis. We examined localization acuity and phonotaxis behavior of females in response to advertisement calls presented from 12 azimuthal angles, at two signal levels, in the presence and absence of noise, and at two noise levels. Orientation responses were consistent with precise localization of sound sources, rather than binary discrimination between sources on either side of the body (lateralization). Frogs were unable to discriminate between sounds arriving from forward and rearward directions, and accurate localization was limited to forward sound presentation angles. Within this region, sound presentation angle had little effect on localization acuity. The presence of noise and low signal-to-noise ratios also did not strongly impair localization ability in open loop trials, but females exhibited reduced phonotaxis performance consistent with impaired localization during closed loop trials. We discuss these results in light of previous work on spatial hearing in anurans.

  12. Spatial hearing in Cope’s gray treefrog: I. Open and closed loop experiments on sound localization in the presence and absence of noise

    PubMed Central

    Caldwell, Michael S.; Bee, Mark A.

    2014-01-01

    The ability to reliably locate sound sources is critical to anurans, which navigate acoustically complex breeding choruses when choosing mates. Yet, the factors influencing sound localization performance in frogs remain largely unexplored. We applied two complementary methodologies, open and closed loop playback trials, to identify influences on localization abilities in Cope’s gray treefrog, Hyla chrysoscelis. We examined localization acuity and phonotaxis behavior of females in response to advertisement calls presented from 12 azimuthal angles, at two signal levels, in the presence and absence of noise, and at two noise levels. Orientation responses were consistent with precise localization of sound sources, rather than binary discrimination between sources on either side of the body (lateralization). Frogs were unable to discriminate between sounds arriving from forward and rearward directions, and accurate localization was limited to forward sound presentation angles. Within this region, sound presentation angle had little effect on localization acuity. The presence of noise and low signal-to-noise ratios also did not strongly impair localization ability in open loop trials, but females exhibited reduced phonotaxis performance consistent with impaired localization during closed loop trials. We discuss these results in light of previous work on spatial hearing in anurans. PMID:24504182

  13. Climate Change Impact: The Experience of the Coastal Areas of Bangladesh Affected by Cyclones Sidr and Aila.

    PubMed

    Kabir, Russell; Khan, Hafiz T A; Ball, Emma; Caldwell, Kay

    2016-01-01

    Bangladesh is considered one of the countries most at risk to the effects of climate change and its coastal area is most vulnerable. This study tries to explore the experiences of cyclones Sidr and Aila affected people living in the coastal areas of Bangladesh. This study was conducted in the cyclone Sidr affected Amtali Upazila of Barguna District and in the cyclone Aila affected Koyra Upazila of Khulna District. Primary data collection was done using Focus Group Interview and then a thematic analysis approach was used for analysis. Three core themes emerged from the analysis and they are, firstly, impacts of climate change on the socioeconomic condition of the people, secondly, the impact on the health status of the population, and finally the impact on vulnerable people. Findings show that the effects of climate change have serious consequences on the livelihood patterns of the affected population and on their overall health status. As a result, the unfavorable health condition of these affected people makes them more vulnerable to various emerging diseases.

  14. The Madrid Affective Database for Spanish (MADS): Ratings of Dominance, Familiarity, Subjective Age of Acquisition and Sensory Experience

    PubMed Central

    Hinojosa, José A.; Rincón-Pérez, Irene; Romero-Ferreiro, Mª Verónica; Martínez-García, Natalia; Villalba-García, Cristina; Montoro, Pedro R.; Pozo, Miguel A.

    2016-01-01

    The current study presents ratings by 540 Spanish native speakers for dominance, familiarity, subjective age of acquisition (AoA), and sensory experience (SER) for the 875 Spanish words included in the Madrid Affective Database for Spanish (MADS). The norms can be downloaded as supplementary materials for this manuscript from https://figshare.com/s/8e7b445b729527262c88 These ratings may be of potential relevance to researches who are interested in characterizing the interplay between language and emotion. Additionally, with the aim of investigating how the affective features interact with the lexicosemantic properties of words, we performed correlational analyses between norms for familiarity, subjective AoA and SER, and scores for those affective variables which are currently included in the MADs. A distinct pattern of significant correlations with affective features was found for different lexicosemantic variables. These results show that familiarity, subjective AoA and SERs may have independent effects on the processing of emotional words. They also suggest that these psycholinguistic variables should be fully considered when formulating theoretical approaches to the processing of affective language. PMID:27227521

  15. The Madrid Affective Database for Spanish (MADS): Ratings of Dominance, Familiarity, Subjective Age of Acquisition and Sensory Experience.

    PubMed

    Hinojosa, José A; Rincón-Pérez, Irene; Romero-Ferreiro, M Verónica; Martínez-García, Natalia; Villalba-García, Cristina; Montoro, Pedro R; Pozo, Miguel A

    2016-01-01

    The current study presents ratings by 540 Spanish native speakers for dominance, familiarity, subjective age of acquisition (AoA), and sensory experience (SER) for the 875 Spanish words included in the Madrid Affective Database for Spanish (MADS). The norms can be downloaded as supplementary materials for this manuscript from https://figshare.com/s/8e7b445b729527262c88 These ratings may be of potential relevance to researches who are interested in characterizing the interplay between language and emotion. Additionally, with the aim of investigating how the affective features interact with the lexicosemantic properties of words, we performed correlational analyses between norms for familiarity, subjective AoA and SER, and scores for those affective variables which are currently included in the MADs. A distinct pattern of significant correlations with affective features was found for different lexicosemantic variables. These results show that familiarity, subjective AoA and SERs may have independent effects on the processing of emotional words. They also suggest that these psycholinguistic variables should be fully considered when formulating theoretical approaches to the processing of affective language.

  16. Climate Change Impact: The Experience of the Coastal Areas of Bangladesh Affected by Cyclones Sidr and Aila

    PubMed Central

    Khan, Hafiz T. A.; Ball, Emma; Caldwell, Kay

    2016-01-01

    Bangladesh is considered one of the countries most at risk to the effects of climate change and its coastal area is most vulnerable. This study tries to explore the experiences of cyclones Sidr and Aila affected people living in the coastal areas of Bangladesh. This study was conducted in the cyclone Sidr affected Amtali Upazila of Barguna District and in the cyclone Aila affected Koyra Upazila of Khulna District. Primary data collection was done using Focus Group Interview and then a thematic analysis approach was used for analysis. Three core themes emerged from the analysis and they are, firstly, impacts of climate change on the socioeconomic condition of the people, secondly, the impact on the health status of the population, and finally the impact on vulnerable people. Findings show that the effects of climate change have serious consequences on the livelihood patterns of the affected population and on their overall health status. As a result, the unfavorable health condition of these affected people makes them more vulnerable to various emerging diseases. PMID:27867400

  17. Bias to pollen odors is affected by early exposure and foraging experience.

    PubMed

    Arenas, A; Farina, W M

    2014-07-01

    In many pollinating insects, foraging preferences are adjusted on the basis of floral cues learned at the foraging site. In addition, olfactory experiences gained at early adult stages might also help them to initially choose food sources. To understand pollen search behavior of honeybees, we studied how responses elicited by pollen-based odors are biased in foraging-age workers according to (i) their genetic predisposition to collect pollen, (ii) pollen related information gained during foraging and (iii) different experiences with pollen gained at early adult ages. Bees returning to the hive carrying pollen loads, were strongly biased to unfamiliar pollen bouquets when tested in a food choice device against pure odors. Moreover, pollen foragers' orientation response was specific to the odors emitted by the pollen type they were carrying on their baskets, which suggests that foragers retrieve pollen odor information to recognize rewarding flowers outside the hive. We observed that attraction to pollen odor was mediated by the exposure to a pollen diet during the first week of life. We did not observe the same attraction in foraging-age bees early exposed to an artificial diet that did not contain pollen. Contrary to the specific response observed to cues acquired during foraging, early exposure to single-pollen diets did not bias orientation response towards a specific pollen odor in foraging-age bees (i.e. bees chose equally between the exposed and the novel monofloral pollen odors). Our results show that pollen exposure at early ages together with olfactory experiences gained in a foraging context are both relevant to bias honeybees' pollen search behavior.

  18. Soil type affects Pinus ponderosa var. scopulorum (Pinaceae) seedling growth in simulated drought experiments1

    PubMed Central

    Lindsey, Alexander J.; Kilgore, Jason S.

    2013-01-01

    • Premise of the study: Effects of drought stress and media type interactions on growth of Pinus ponderosa var. scopulorum germinants were investigated. • Methods and Results: Soil properties and growth responses under drought were compared across four growth media types: two native soils (dolomitic limestone and granite), a soil-less industry standard conifer medium, and a custom-mixed conifer medium. After 35 d of growth, the seedlings under drought stress (reduced watering) produced less shoot and root biomass than watered control seedlings. Organic media led to decreased root biomass, but increased root length and shoot biomass relative to the mineral soils. • Conclusions: Media type affected root-to-shoot biomass partitioning of P. ponderosa var. scopulorum, which may influence net photosynthetic rates, growth, and long-term seedling survival. Further work should examine how specific soil properties like bulk density and organic matter influence biomass allocation in greenhouse studies. PMID:25202578

  19. Quantitation of interactions between two DNA loops demonstrates loop domain insulation in E. coli cells

    PubMed Central

    Priest, David G.; Kumar, Sandip; Yan, Yan; Dunlap, David D.; Dodd, Ian B.; Shearwin, Keith E.

    2014-01-01

    Eukaryotic gene regulation involves complex patterns of long-range DNA-looping interactions between enhancers and promoters, but how these specific interactions are achieved is poorly understood. Models that posit other DNA loops—that aid or inhibit enhancer–promoter contact—are difficult to test or quantitate rigorously in eukaryotic cells. Here, we use the well-characterized DNA-looping proteins Lac repressor and phage λ CI to measure interactions between pairs of long DNA loops in E. coli cells in the three possible topological arrangements. We find that side-by-side loops do not affect each other. Nested loops assist each other’s formation consistent with their distance-shortening effect. In contrast, alternating loops, where one looping element is placed within the other DNA loop, inhibit each other’s formation, thus providing clear support for the loop domain model for insulation. Modeling shows that combining loop assistance and loop interference can provide strong specificity in long-range interactions. PMID:25288735

  20. Juvenile social experience affects pairing success at adulthood: congruence with the loser effect?

    PubMed Central

    Mariette, Mylene M.; Cathaud, Charlène; Chambon, Rémi; Vignal, Clémentine

    2013-01-01

    Social interactions with adults are often critical for the development of mating behaviours. However, the potential role of other primary social partners such as juvenile counterparts is rarely considered. Most interestingly, it is not known whether interactions with juvenile females improve males’ courtship and whether, similar to the winner and loser effects in a fighting context—outcome of these interactions shapes males’ behaviour in future encounters. We investigated the combined effects of male quality and juvenile social experience on pairing success at adulthood in zebra finches (Taeniopygia guttata). We manipulated brood size to alter male quality and then placed males in either same- or mixed-sex juvenile dyads until adulthood. We found that males from reduced broods obtained more copulations and males from mixed-sex dyads had more complete courtships. Furthermore, independent of their quality, males that failed to pair with juvenile females, but not juvenile males, had a lower pairing success at adulthood. Our study shows that negative social experience with peers during adolescence may be a potent determinant of pairing success that can override the effects of early environmental conditions on male attractiveness and thereby supports the occurrence of an analogous process to the loser effect in a mating context. PMID:23902911

  1. Adolescent Experience Affects Postnatal Ultrasonic Vocalizations and Gene Expression in Future Offspring

    PubMed Central

    Bodi, Caroline M.; Vassoler, Fair M.; Byrnes, Elizabeth M.

    2017-01-01

    The present study measured postnatal ultrasonic vocalization (USV) and gene expression to examine potential changes in communication and/or attachment in the offspring of mothers exposed to morphine during adolescence. Offspring of morphine-exposed (Mor-F1), saline-exposed (Sal-F1), or non-handled control (Con-F1) female Sprague–Dawley rats were tested for separation-induced distress calls and maternal potentiation of distress calls during early postnatal development. We also examined relative expression of dopamine D2 receptor and mu opioid receptor (oprm1) mRNA in the nucleus accumbens and hypothalamus in these offspring, as their activity has been implicated in the regulation of postnatal USV in response to maternal separation. The findings indicate that adolescent experiences of future mothers, including their 10 daily saline or morphine injections, can result in significant region-specific differences in gene expression. In addition, these experiences resulted in fewer numbers of separation-induced distress calls produced by offspring. In contrast, augmented maternal potentiation was only observed in Mor-F1 offspring. PMID:26999300

  2. A field experiment shows that subtle linguistic cues might not affect voter behavior.

    PubMed

    Gerber, Alan S; Huber, Gregory A; Biggers, Daniel R; Hendry, David J

    2016-06-28

    One of the most important recent developments in social psychology is the discovery of minor interventions that have large and enduring effects on behavior. A leading example of this class of results is in the work by Bryan et al. [Bryan CJ, Walton GM, Rogers T, Dweck CS (2011) Proc Natl Acad Sci USA 108(31):12653-12656], which shows that administering a set of survey items worded so that subjects think of themselves as voters (noun treatment) rather than as voting (verb treatment) substantially increases political participation (voter turnout) among subjects. We revisit these experiments by replicating and extending their research design in a large-scale field experiment. In contrast to the 11 to 14% point greater turnout among those exposed to the noun rather than the verb treatment reported in the work by Bryan et al., we find no statistically significant difference in turnout between the noun and verb treatments (the point estimate of the difference is approximately zero). Furthermore, when we benchmark these treatments against a standard get out the vote message, we estimate that both are less effective at increasing turnout than a much shorter basic mobilization message. In our conclusion, we detail how our study differs from the work by Bryan et al. and discuss how our results might be interpreted.

  3. Closed-Loop Neuromorphic Benchmarks

    PubMed Central

    Stewart, Terrence C.; DeWolf, Travis; Kleinhans, Ashley; Eliasmith, Chris

    2015-01-01

    Evaluating the effectiveness and performance of neuromorphic hardware is difficult. It is even more difficult when the task of interest is a closed-loop task; that is, a task where the output from the neuromorphic hardware affects some environment, which then in turn affects the hardware's future input. However, closed-loop situations are one of the primary potential uses of neuromorphic hardware. To address this, we present a methodology for generating closed-loop benchmarks that makes use of a hybrid of real physical embodiment and a type of “minimal” simulation. Minimal simulation has been shown to lead to robust real-world performance, while still maintaining the practical advantages of simulation, such as making it easy for the same benchmark to be used by many researchers. This method is flexible enough to allow researchers to explicitly modify the benchmarks to identify specific task domains where particular hardware excels. To demonstrate the method, we present a set of novel benchmarks that focus on motor control for an arbitrary system with unknown external forces. Using these benchmarks, we show that an error-driven learning rule can consistently improve motor control performance across a randomly generated family of closed-loop simulations, even when there are up to 15 interacting joints to be controlled. PMID:26696820

  4. Disrupted by disaster: shared experiences of student registered nurse anesthetists affected by hurricane Katrina.

    PubMed

    Geisz-Everson, Marjorie A; Bennett, Marsha J; Dodd-McCue, Diane; Biddle, Chuck

    2012-01-01

    The purpose of this focused ethnography was to describe the shared experiences of student registered nurse anesthetists (SRNAs) whose senior year of education and training was disrupted by Hurricane Katrina, as well as to determine the storm's psychosocial impact on them. A convenience sample of 10 former SRNAs participated in focus groups that were audiorecorded, transcribed, and qualitatively analyzed. Three major themes emerged from the study: Seriousness of Urgency, Managing Uncertainty, and Stability Equaled Relief. The themes represented how the SRNAs appraised and coped with the stressful events surrounding Hurricane Katrina. The psychosocial impact of Hurricane Katrina on the SRNAs resulted mainly in temporary increased alcohol consumption and short-term anxiety. One person started smoking. The results of this study should serve as a guide to formulate policies regarding the education of SRNAs during and immediately after a disaster and to provide a framework for future disaster studies regarding SRNAs.

  5. Ocean acidification affects iron speciation during a coastal seawater mesocosm experiment

    NASA Astrophysics Data System (ADS)

    Breitbarth, E.; Bellerby, R. J.; Neill, C. C.; Ardelan, M. V.; Meyerhöfer, M.; Zöllner, E.; Croot, P. L.; Riebesell, U.

    2010-03-01

    Rising atmospheric CO2 is acidifying the surface ocean, a process which is expected to greatly influence the chemistry and biology of the future ocean. Following the development of iron-replete phytoplankton blooms in a coastal mesocosm experiment at 350, 700, and 1050 μatm pCO2, we observed significant increases in dissolved iron concentrations, Fe(II) concentrations, and Fe(II) half-life times during and after the peak of blooms in response to CO2 enrichment and concomitant lowering of pH, suggesting increased iron bioavailability. If applicable to the open ocean this may provide a negative feedback mechanism to the rising atmospheric CO2 by stimulating marine primary production.

  6. Who can communicate with whom? Language experience affects infants' evaluation of others as monolingual or multilingual.

    PubMed

    Pitts, Casey E; Onishi, Kristine H; Vouloumanos, Athena

    2015-01-01

    Adults recognize that people can understand more than one language. However, it is unclear whether infants assume other people understand one or multiple languages. We examined whether monolingual and bilingual 20-month-olds expect an unfamiliar person to understand one or more than one language. Two speakers told a listener the location of a hidden object using either the same or two different languages. When different languages were spoken, monolinguals looked longer when the listener searched correctly, bilinguals did not; when the same language was spoken, both groups looked longer for incorrect searches. Infants rely on their prior language experience when evaluating the language abilities of a novel individual. Monolingual infants assume others can understand only one language, although not necessarily the infants' own; bilinguals do not. Infants' assumptions about which community of conventions people belong to may allow them to recognize effective communicative partners and thus opportunities to acquire language, knowledge, and culture.

  7. The interaction of early life experiences with COMT val158met affects anxiety sensitivity.

    PubMed

    Baumann, C; Klauke, B; Weber, H; Domschke, K; Zwanzger, P; Pauli, P; Deckert, J; Reif, A

    2013-11-01

    The pathogenesis of anxiety disorders is considered to be multifactorial with a complex interaction of genetic factors and individual environmental factors. Therefore, the aim of this study was to examine gene-by-environment interactions of the genes coding for catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAOA) with life events on measures related to anxiety. A sample of healthy subjects (N = 782; thereof 531 women; mean age M = 24.79, SD = 6.02) was genotyped for COMT rs4680 and MAOA-uVNTR (upstream variable number of tandem repeats), and was assessed for childhood adversities [Childhood Trauma Questionnaire (CTQ)], anxiety sensitivity [Anxiety Sensitivity Index (ASI)] and anxious apprehension [Penn State Worry Questionnaire (PSWQ)]. Main and interaction effects of genotype, environment and gender on measures related to anxiety were assessed by means of regression analyses. Association analysis showed no main gene effect on either questionnaire score. A significant interactive effect of childhood adversities and COMT genotype was observed: Homozygosity for the low-active met allele and high CTQ scores was associated with a significant increment of explained ASI variance [R(2) = 0.040, false discovery rate (FDR) corrected P = 0.04]. A borderline interactive effect with respect to MAOA-uVNTR was restricted to the male subgroup. Carriers of the low-active MAOA allele who reported more aversive experiences in childhood exhibited a trend for enhanced anxious apprehension (R(2) = 0.077, FDR corrected P = 0.10). Early aversive life experiences therefore might increase the vulnerability to anxiety disorders in the presence of homozygosity for the COMT 158met allele or low-active MAOA-uVNTR alleles.

  8. Pseudonoise code tracking loop

    NASA Technical Reports Server (NTRS)

    Laflame, D. T. (Inventor)

    1980-01-01

    A delay-locked loop is presented for tracking a pseudonoise (PN) reference code in an incoming communication signal. The loop is less sensitive to gain imbalances, which can otherwise introduce timing errors in the PN reference code formed by the loop.

  9. Non-defendable resources affect peafowl lek organization: a male removal experiment.

    PubMed

    Loyau, Adeline; Jalme, Michel Saint; Sorci, Gabriele

    2007-01-10

    A lekking mating system is typically thought to be non-resource based with male providing nothing to females but genes. However, males are thought to clump their display sites on areas where they are more likely to encounter females, which may depend on non-defendable resource location. We tested this hypothesis on a feral population of peacocks. In agreement, we found that, within the lek, display site proximity to food resources had an effect on female visitation rate and male mating success. The attractiveness of display sites to male intruders was explained by the distance to the feeding place and by the female visitation rate. We randomly removed 29 territorial males from their display sites. Display sites that were more attractive to male intruders before removal remained highly attractive after removal and display sites closer to the feeding area attracted the attention of intruders significantly more after removal. Similarly, display sites that were more visited by females before removal remained more visited after removal, suggesting again that the likelihood of encountering females is determined by the display site location. Overall, these results are in agreement with non-defendable resources affecting lek spatial organization in the peafowl.

  10. Factors affecting angular deformities of the knees in Nigerian children--Ilorin experience.

    PubMed

    Agaja, S B

    2001-01-01

    44 children with angular knee deformities were studied at the University of Ilorin Teaching Hospital from September 1994 to December, 1997. There were 19 males (43.2%) and 25 females (56.8%). The commonest age range was 0-5 years age range (81.5%). Bilateral angular deformities are more common than unilateral angular deformities. Windswept deformities accounted for 16 cases(36.4%), bilateral Genu Varum accounted for 15 cases (34.0%), and unilateral Genu Valgum, 8 cases (18.2%). It was found in the study that 40 cases (90.9%) were from urban communities while 4 cases (9.1%) were from rural communities. The angular knee deformities affect both Christian and Moslem children alike; however, the environmental factor is the restriction of children indoors which is a serious factor in the causation of Nutritional Rickets. Angular deformities of the knee were far more common amongst urban dwellers than in children from rural area (Ratio 10:1) while involvement of both knees (88.6%) simultaneously is also more common than single knee involvement (11.4%). Some of the objectives of the investigation were to find out the implications of the angular deformities to parents and children; and ways to prevent occurrence were also discussed in this paper.

  11. "So We Adapt Step by Step": Acculturation experiences affecting diabetes management and perceived health for Chinese American immigrants.

    PubMed

    Chun, Kevin M; Chesla, Catherine A; Kwan, Christine M L

    2011-01-01

    This study examines how acculturation affects type 2 diabetes management and perceived health for Chinese American immigrants in the U.S. Acculturation experiences or cultural adaptation experiences affecting diabetes management and health were solicited from an informant group of immigrant patients and their spouses (N = 40) during group, couple and individual interviews conducted from 2005 to 2008. A separate respondent group of immigrant patients and their spouses (N = 19) meeting inclusion criteria reviewed and confirmed themes generated by the informant group. Using interpretive phenomenology, three key themes in patients' and spouses' acculturation experiences were identified: a) utilizing health care, b) maintaining family relations and roles, and c) establishing community ties and groundedness in the U.S. Acculturation experiences reflecting these themes were broad in scope and not fully captured by current self-report and proxy acculturation measures. In the current study, shifting family roles and evaluations of diabetes care and physical environment in the U.S. significantly affected diabetes management and health, yet are overlooked in acculturation and health investigations. Furthermore, the salience and impact of specific acculturation experiences respective to diabetes management and perceived health varied across participants due to individual, family, developmental, and environmental factors. In regards to salience, maintaining filial and interdependent family relations in the U.S. was of particular concern for older participants and coping with inadequate health insurance in the U.S. was especially distressing for self-described lower-middle to middle-class participants. In terms of impact, family separation and relocating to ethnically similar neighborhoods in the U.S. differentially affected diabetes management and health due to participants' varied family relations and pre-migration family support levels and diverse cultural and linguistic

  12. Health and Illness in a Connected World: How Might Sharing Experiences on the Internet Affect People's Health?

    PubMed Central

    Ziebland, Sue; Wyke, Sally

    2012-01-01

    Context The use of the Internet for peer-to-peer connection has been one of its most dramatic and transformational features. Yet this is a new field with no agreement on a theoretical and methodological basis. The scientific base underpinning this activity needs strengthening, especially given the explosion of web resources that feature experiences posted by patients themselves. This review informs a National Institute for Health Research (NIHR) (UK) research program on the impact of online patients’ accounts of their experiences with health and health care, which includes the development and validation of a new e-health impact questionnaire. Methods We drew on realist review methods to conduct a conceptual review of literature in the social and health sciences. We developed a matrix to summarize the results, which we then distilled from a wide and diverse reading of the literature. We continued reading until we reached data saturation and then further refined the results after testing them with expert colleagues and a public user panel. Findings We identified seven domains through which online patients’ experiences could affect health. Each has the potential for positive and negative impacts. Five of the identified domains (finding information, feeling supported, maintaining relationships with others, affecting behavior, and experiencing health services) are relatively well rehearsed, while two (learning to tell the story and visualizing disease) are less acknowledged but important features of online resources. Conclusions The value of first-person accounts, the appeal and memorability of stories, and the need to make contact with peers all strongly suggest that reading and hearing others’ accounts of their own experiences of health and illnesss will remain a key feature of e-health. The act of participating in the creation of health information (e.g., through blogging and contributing to social networking on health topics) also influences patients

  13. Do reports on drinking water quality affect customers' concerns? Experiments in report content.

    PubMed

    Johnson, Branden B

    2003-10-01

    The Safe Drinking Water Act Amendments of 1996 required U.S. utilities to report on drinking water quality to their customers annually, beginning in fall 1999, on the assumption that such reports would alert them to quality problems and perhaps mobilize pressure for improvement. A random sample of New Jersey customers read alternative versions of a water quality report, in an experiment on reactions to water quality information under U.S. Environmental Protection Agency (USEPA) rules. Experiment design was 2 x 3 + 1: two versions each--one with, one without, a violation of a health standard--of a report that was (1) Qualitative (without water quality numbers, thus not meeting USEPA rules); (2) Basic, with minimal information meeting the rules; or (3) Extended, adding reading aids and utility performance information; plus a control instrument without any hypothetical report. Results of ANOVA suggest the reports will have less effect than hoped or feared. These manipulations were successful: people reading the Qualitative versions were less likely to say that the report gave the amounts of substances found in the water, and those reading Violation versions were more likely to report a violation of a health standard. The main differences in responses to the report involved the judged adequacy of the information, and to a lesser extent responses on a Concern scale (constructed from measures of concern, judged risk, clean-up intentions, distrust of utility information, and doubt that the utility was doing all it could to improve water quality). Overall judgments of water quality and utility performance did not change, either relative to the controls or in before versus after responses. Qualitative reports performed worse than others, confirming the decision to have utilities report actual contaminant levels. Extended reports did only slightly better than the Basic versions on these measures. Many respondents had trouble identifying the presence or absence of substance

  14. The relation of expression recognition and affective experience in facial expression processing: an event-related potential study

    PubMed Central

    Dong, Guangheng; Lu, Shenglan

    2010-01-01

    The present study investigates the relationship of expression recognition and affective experience during facial expression processing by event-related potentials (ERP). Facial expressions used in the present study can be divided into three categories: positive (happy), neutral (neutral), and negative (angry). Participants were asked to finish two kinds of facial recognition tasks: one was easy, and the other was difficult. In the easy task, significant main effects were found for different valence conditions, meaning that emotions were evoked effectively when participants recognized the expressions in facial expression processing. However, no difference was found in the difficult task, meaning that even if participants had identified the expressions correctly, no relevant emotion was evoked during the process. The findings suggest that emotional experience was not simultaneous with expression identification in facial expression processing, and the affective experience process could be suppressed in challenging cognitive tasks. The results indicate that we should pay attention to the level of cognitive load when using facial expressions as emotion-eliciting materials in emotion studies; otherwise, the emotion may not be evoked effectively. PMID:22110330

  15. A female's past experience with predators affects male courtship and the care her offspring will receive from their father.

    PubMed

    McGhee, Katie E; Feng, Sally; Leasure, Sagan; Bell, Alison M

    2015-11-22

    Differential allocation occurs when individuals adjust their reproductive investment based on their partner's traits. However, it remains unknown whether animals differentially allocate based on their partner's past experiences with predation risk. If animals can detect a potential mate's experience with predators, this might inform them about the stress level of their potential mate, the likelihood of parental effects in offspring and/or the dangers present in the environment. Using threespined stickleback (Gasterosteus aculeatus), we examined whether a female's previous experience with being chased by a model predator while yolking eggs affects male mating effort and offspring care. Males displayed fewer conspicuous courtship behaviours towards females that had experienced predation risk in the past compared with unexposed females. This differential allocation extended to how males cared for the resulting offspring of these matings: fathers provided less parental care to offspring of females that had experienced predation risk in the past. Our results show for the first time, to our knowledge, that variation among females in their predator encounters can contribute to behavioural variation among males in courtship and parental care, even when males themselves do not encounter a predator. These results, together with previous findings, suggest that maternal predator exposure can influence offspring development both directly and indirectly, through how it affects father care.

  16. Factors affecting the quality of anticoagulation with warfarin: experience of one cardiac centre

    PubMed Central

    Ciurus, Tomasz; Cichocka-Radwan, Anna

    2015-01-01

    Introduction The risk of complications in anticoagulation therapy can be reduced by maximising the percentage of time spent by the patient in the optimal therapeutic range (TTR). However, little is known about the predictors of anticoagulation control. The aim of this paper was to assess the quality of anticoagulant therapy in patients on warfarin and to identify the factors affecting its deterioration. Material and methods We studied 149 patients who required anticoagulant therapy with warfarin due to non-valvular atrial fibrillation and/or venous thromboembolism. Each patient underwent proper training regarding the implemented treatment and remained under constant medical care. Results The mean age of the patients was 68.8 ± 12.6 years, and 59% were male. A total of 2460 international normalised ratio (INR) measurements were collected during the 18-month period. The mean TTR in the studied cohort was 76 ± 21%, and the median was 80%. The level at which high-quality anticoagulation was recorded for this study was based on TTR values above 80%. Seventy-five patients with TTR ≥ 80% were included in the stable anticoagulation group (TTR ≥ 80%); the remaining 74 patients constituted the unstable anticoagulation group (TTR < 80%). According to multivariate stepwise regression analysis, the independent variables increasing the risk of deterioration of anticoagulation quality were: arterial hypertension (OR 2.74 [CI 95%: 1.06-7.10]; p = 0.038), amiodarone therapy (OR 4.22 [CI 95%: 1.30-13.70]; p = 0.017), and obesity (OR 1.11 [CI 95%: 1.02-1.21]; p = 0.013). Conclusions The presence of obesity, hypertension, or amiodarone therapy decreases the quality of anticoagulation with warfarin. High quality of anticoagulation can be achieved through proper monitoring and education of patients. PMID:26855650

  17. Electronic Circuit Experiments and SPICE Simulation of Double Covering Bifurcation of 2-Torus Quasi-Periodic Flow in Phase-Locked Loop Circuit

    NASA Astrophysics Data System (ADS)

    Kamiyama, Kyohei; Endo, Tetsuro; Imai, Isao; Komuro, Motomasa

    2016-06-01

    Double covering (DC) bifurcation of a 2-torus quasi-periodic flow in a phase-locked loop circuit was experimentally investigated using an electronic circuit and via SPICE simulation; in the circuit, the input radio-frequency signal was frequency modulated by the sum of two asynchronous sinusoidal baseband signals. We observed both DC and period-doubling bifurcations of a discrete map on two Poincaré sections, which were realized by changing the sample timing from one baseband sinusoidal signal to the other. The results confirm the DC bifurcation of the original flow.

  18. How does tree density affect water loss of peatlands? A mesocosm experiment.

    PubMed

    Limpens, Juul; Holmgren, Milena; Jacobs, Cor M J; Van der Zee, Sjoerd E A T M; Karofeld, Edgar; Berendse, Frank

    2014-01-01

    Raised bogs have accumulated more atmospheric carbon than any other terrestrial ecosystem on Earth. Climate-induced expansion of trees and shrubs may turn these ecosystems from net carbon sinks into sources when associated with reduced water tables. Increasing water loss through tree evapotranspiration could potentially deepen water tables, thus stimulating peat decomposition and carbon release. Bridging the gap between modelling and field studies, we conducted a three-year mesocosm experiment subjecting natural bog vegetation to three birch tree densities, and studied the changes in subsurface temperature, water balance components, leaf area index and vegetation composition. We found the deepest water table in mesocosms with low tree density. Mesocosms with high tree density remained wettest (i.e. highest water tables) whereas the control treatment without trees had intermediate water tables. These differences are attributed mostly to differences in evapotranspiration. Although our mesocosm results cannot be directly scaled up to ecosystem level, the systematic effect of tree density suggests that as bogs become colonized by trees, the effect of trees on ecosystem water loss changes with time, with tree transpiration effects of drying becoming increasingly offset by shading effects during the later phases of tree encroachment. These density-dependent effects of trees on water loss have important implications for the structure and functioning of peatbogs.

  19. The Dynamic Reactance Interaction - How Vested Interests Affect People's Experience, Behavior, and Cognition in Social Interactions.

    PubMed

    Steindl, Christina; Jonas, Eva

    2015-01-01

    In social interactions, individuals may sometimes pursue their own interests at the expense of their interaction partner. Such self-interested behaviors impose a threat to the interaction partner's freedom to act. The current article investigates this threat in the context of interdependence and reactance theory. We explore how vested interests influence reactance process stages of an advisor-client interaction. We aim to explore the interactional process that evolves. In two studies, participants took the perspective of a doctor (advisor) or a patient (client). In both studies we incorporated a vested interest. In Study 1 (N = 82) we found that in response to a vested interest of their interaction partner, patients indicated a stronger experience of reactance, more aggressive behavioral intentions, and more biased cognitions than doctors. A serial multiple mediation revealed that a vested interest engendered mistrust toward the interaction partner and this mistrust led to an emerging reactance process. Study 2 (N = 207) further demonstrated that doctors expressed their reactance in a subtle way: they revealed a classic confirmation bias when searching for additional information on their preliminary decision preference, indicating stronger defense motivation. We discuss how these findings can help us to understand how social interactions develop dynamically.

  20. Biotherapeutic formulation factors affecting metal leachables from stainless steel studied by design of experiments.

    PubMed

    Zhou, Shuxia; Evans, Brad; Schöneich, Christian; Singh, Satish K

    2012-03-01

    Trace amounts of metals are inevitably present in biotherapeutic products. They can arise from various sources. The impact of common formulation factors such as protein concentration, antioxidant, metal chelator concentration and type, surfactant, pH, and contact time with stainless steel on metal leachables was investigated by a design of experiments approach. Three major metal leachables, iron, chromium, and nickel were monitored by inductively coupled plasma-mass spectrometry. It was observed that among all the tested factors, contact time, metal chelator concentration, and protein concentration were statistically significant factors with higher temperature resulting in higher levels of leached metals. Within a pH range of 5.5-6.5, solution pH played a minor role for chromium leaching at 25°C. No statistically significant difference was observed due to type of chelator, presence of antioxidant, or surfactant. In order to optimize a biotherapeutic formulation to achieve a target drug product shelf life with acceptable quality, each formulation component must be evaluated for its impact.

  1. How Does Tree Density Affect Water Loss of Peatlands? A Mesocosm Experiment

    PubMed Central

    Limpens, Juul; Holmgren, Milena; Jacobs, Cor M. J.; Van der Zee, Sjoerd E. A. T. M.; Karofeld, Edgar; Berendse, Frank

    2014-01-01

    Raised bogs have accumulated more atmospheric carbon than any other terrestrial ecosystem on Earth. Climate-induced expansion of trees and shrubs may turn these ecosystems from net carbon sinks into sources when associated with reduced water tables. Increasing water loss through tree evapotranspiration could potentially deepen water tables, thus stimulating peat decomposition and carbon release. Bridging the gap between modelling and field studies, we conducted a three-year mesocosm experiment subjecting natural bog vegetation to three birch tree densities, and studied the changes in subsurface temperature, water balance components, leaf area index and vegetation composition. We found the deepest water table in mesocosms with low tree density. Mesocosms with high tree density remained wettest (i.e. highest water tables) whereas the control treatment without trees had intermediate water tables. These differences are attributed mostly to differences in evapotranspiration. Although our mesocosm results cannot be directly scaled up to ecosystem level, the systematic effect of tree density suggests that as bogs become colonized by trees, the effect of trees on ecosystem water loss changes with time, with tree transpiration effects of drying becoming increasingly offset by shading effects during the later phases of tree encroachment. These density-dependent effects of trees on water loss have important implications for the structure and functioning of peatbogs. PMID:24632565

  2. Design of experiment (DOE) based screening of factors affecting municipal solid waste (MSW) composting.

    PubMed

    Kazemi, Khoshrooz; Zhang, Baiyu; Lye, Leonard M; Cai, Qinghong; Cao, Tong

    2016-12-01

    A design of experiment (DOE) based methodology was adopted in this study to investigate the effects of multiple factors and their interactions on the performance of a municipal solid waste (MSW) composting process. The impact of four factors, carbon/nitrogen ratio (C/N), moisture content (MC), type of bulking agent (BA) and aeration rate (AR) on the maturity, stability and toxicity of compost product was investigated. The statistically significant factors were identified using final C/N, germination index (GI) and especially the enzyme activities as responses. Experimental results validated the use of enzyme activities as proper indices during the course of composting. Maximum enzyme activities occurred during the active phase of decomposition. MC has a significant effect on dehydrogenase activity (DGH), β-glucosidase activity (BGH), phosphodiesterase activity (PDE) and the final moisture content of the compost. C/N is statistically significant for final C/N, DGH, BGH, and GI. The results provided guidance to optimize a MSW composting system that will lead to increased decomposition rate and the production of more stable and mature compost.

  3. Looping charged elastic rods: applications to protein-induced DNA loop formation.

    PubMed

    Cherstvy, A G

    2011-01-01

    We analyze looping of thin charged elastic filaments under applied torques and end forces, using the solution of linear elasticity theory equations. In application to DNA, we account for its polyelectrolyte character and charge renormalization, calculating electrostatic energies stored in the loops. We argue that the standard theory of electrostatic persistence is only valid when the loop's radius of curvature and close-contact distance are much larger than the Debye screening length. We predict that larger twist rates are required to trigger looping of charged rods as compared with neutral ones. We then analyze loop shapes formed on charged filaments of finite length, mimicking DNA looping by proteins with two DNA-binding domains. We find optimal loop shapes at different salt amounts, minimizing the sum of DNA elastic, DNA electrostatic, and protein elastic energies. We implement a simple model where intercharge repulsions do not affect the loop shape directly but can choose the energy-optimized shape from the allowed loop types. At low salt concentrations more open loops are favored due to enhanced repulsion of DNA charges, consistent with the results of computer simulations on formation of DNA loops by lac repressor. Then, we model the precise geometry of DNA binding by the lac tetramer and explore loop shapes, varying the confined DNA length and protein opening angle. The characteristics of complexes obtained, such as the total loop energy, stretching forces required to maintain its shape, and the reduction of electrostatic energy with increment of salt, are in good agreement with the outcomes of more elaborate numerical calculations for lac-repressor-induced DNA looping.

  4. Radiation Enhanced Absorption of Frank Loops by Nanovoids in Cu

    NASA Astrophysics Data System (ADS)

    Chen, Y.; Zhang, X.; Wang, J.

    2016-01-01

    Neutron and heavy ion irradiations generally induce voids in metallic materials, and continuous radiations typically result in void swelling and mechanical failure of the irradiated materials. Recent experiments showed that nanovoids in nanotwinned copper could act as sinks for radiation-induced Frank loops, significantly mitigating radiation damage. In this paper, we report on structural evolution of Frank loops under cascades and address the role of nanovoids in absorbing Frank loops in detail by using molecular dynamics simulations. Results show that a stand-alone Frank loop is stable under cascades. When Frank loops are adjacent to nanovoids, the diffusion of a group of atoms from the loop into nanovoids is accomplished via the formation and propagation of dislocation loops. The loop-nanovoid interactions result in the shrinkage of the nanovoids and the Frank loops.

  5. Radiation Enhanced Absorption of Frank Loops by Nanovoids in Cu

    SciTech Connect

    Chen, Youxing; Zhang, Xinghang; Wang, Jian

    2016-11-01

    Neutron and heavy ion irradiation generally induces voids in metallic materials, and continuous radiations typically result in void swelling and mechanical failure of the irradiated materials. Recent experiments showed that nanovoids in nanotwinned copper could act as sinks for radiation-induced Frank loops, significantly mitigating radiation damage [Y. Chen et al., Nat. Commun. 6:7036 (2015)]. In this paper, we report on structural evolution of Frank loops under cascades and address the role of nanovoids in absorbing Frank loops in detail by using molecular dynamics simulations. Results show that a stand-alone Frank loop is stable under cascades. When Frank loops are adjacent to nanovoids, the diffusion of a group of atoms from the loop into nanovoids is accomplished via the formation and propagation of dislocation loops. The loop-nanovoid interactions result in the shrinkage of the nanovoids and the Frank loops.

  6. Radiation Enhanced Absorption of Frank Loops by Nanovoids in Cu

    DOE PAGES

    Chen, Youxing; Zhang, Xinghang; Wang, Jian

    2016-11-01

    Neutron and heavy ion irradiation generally induces voids in metallic materials, and continuous radiations typically result in void swelling and mechanical failure of the irradiated materials. Recent experiments showed that nanovoids in nanotwinned copper could act as sinks for radiation-induced Frank loops, significantly mitigating radiation damage [Y. Chen et al., Nat. Commun. 6:7036 (2015)]. In this paper, we report on structural evolution of Frank loops under cascades and address the role of nanovoids in absorbing Frank loops in detail by using molecular dynamics simulations. Results show that a stand-alone Frank loop is stable under cascades. When Frank loops are adjacentmore » to nanovoids, the diffusion of a group of atoms from the loop into nanovoids is accomplished via the formation and propagation of dislocation loops. The loop-nanovoid interactions result in the shrinkage of the nanovoids and the Frank loops.« less

  7. Weed Diversity Affects Soybean and Maize Yield in a Long Term Experiment in Michigan, USA.

    PubMed

    Ferrero, Rosana; Lima, Mauricio; Davis, Adam S; Gonzalez-Andujar, Jose L

    2017-01-01

    Managing production environments in ways that promote weed community diversity may enhance both crop production and the development of a more sustainable agriculture. This study analyzed data of productivity of maize (corn) and soybean in plots in the Main Cropping System Experiment (MCSE) at the W. K. Kellogg Biological Station Long-Term Ecological Research (KBS-LTER) in Michigan, USA, from 1996 to 2011. We used models derived from population ecology to explore how weed diversity, temperature, and precipitation interact with crop yields. Using three types of models that considered internal and external (climate and weeds) factors, with additive or non-linear variants, we found that changes in weed diversity were associated with changes in rates of crop yield increase over time for both maize and soybeans. The intrinsic capacity for soybean yield increase in response to the environment was greater under more diverse weed communities. Soybean production risks were greatest in the least weed diverse systems, in which each weed species lost was associated with progressively greater crop yield losses. Managing for weed community diversity, while suppressing dominant, highly competitive weeds, may be a helpful strategy for supporting long term increases in soybean productivity. In maize, there was a negative and non-additive response of yields to the interaction between weed diversity and minimum air temperatures. When cold temperatures constrained potential maize productivity through limited resources, negative interactions with weed diversity became more pronounced. We suggest that: (1) maize was less competitive in cold years allowing higher weed diversity and the dominance of some weed species; or (2) that cold years resulted in increased weed richness and prevalence of competitive weeds, thus reducing crop yields. Therefore, we propose to control dominant weed species especially in the years of low yield and extreme minimum temperatures to improve maize yields

  8. Weed Diversity Affects Soybean and Maize Yield in a Long Term Experiment in Michigan, USA

    PubMed Central

    Ferrero, Rosana; Lima, Mauricio; Davis, Adam S.; Gonzalez-Andujar, Jose L.

    2017-01-01

    Managing production environments in ways that promote weed community diversity may enhance both crop production and the development of a more sustainable agriculture. This study analyzed data of productivity of maize (corn) and soybean in plots in the Main Cropping System Experiment (MCSE) at the W. K. Kellogg Biological Station Long-Term Ecological Research (KBS-LTER) in Michigan, USA, from 1996 to 2011. We used models derived from population ecology to explore how weed diversity, temperature, and precipitation interact with crop yields. Using three types of models that considered internal and external (climate and weeds) factors, with additive or non-linear variants, we found that changes in weed diversity were associated with changes in rates of crop yield increase over time for both maize and soybeans. The intrinsic capacity for soybean yield increase in response to the environment was greater under more diverse weed communities. Soybean production risks were greatest in the least weed diverse systems, in which each weed species lost was associated with progressively greater crop yield losses. Managing for weed community diversity, while suppressing dominant, highly competitive weeds, may be a helpful strategy for supporting long term increases in soybean productivity. In maize, there was a negative and non-additive response of yields to the interaction between weed diversity and minimum air temperatures. When cold temperatures constrained potential maize productivity through limited resources, negative interactions with weed diversity became more pronounced. We suggest that: (1) maize was less competitive in cold years allowing higher weed diversity and the dominance of some weed species; or (2) that cold years resulted in increased weed richness and prevalence of competitive weeds, thus reducing crop yields. Therefore, we propose to control dominant weed species especially in the years of low yield and extreme minimum temperatures to improve maize yields

  9. Mesocosm experiments to assess factors affecting phosphorus retention and release in an extended Wisconsin wetland

    USGS Publications Warehouse

    Elder, J.F.; Manion, B.J.; Goddard, G.L.

    1997-01-01

    Phosphorus retention by wetland sediments and vegetation was investigated in Jackson Creek wetland, an extension of an existing prairie marsh in southeastern Wisconsin. The extended wetland construction was undertaken in 1992-93 to help reduce the phosphorus loading to a downstream eutrophic lake. Two approaches were used to study potential and actual phosphorus retention in the system. Mesocosm experiments of 20-40 days duration indicated that retention of total and dissolved reactive phosphorus in mesocosm cells containing macrophytes and/or sediments was reduced by factors of 2-20 relative to cells containing only water or a copper algicide to suppress metabolic activity. In contrast to the nutrient trapping function, these results show a potential for net phosphorus release that can be associated with increased biological richness. Measurements of water flow and nutrient loads at the wetland's inflow and outflow points demonstrated 9-39% net uptake of phosphorus on an annual scale but frequent occurrences of net phosphorus release over shorter (one-month) time scales. These episodes of release are most likely during the summer months. Thus, the wetland role in phosphorus cycling is not one of a true source or sink, although the annual budget data alone suggest substantial net retention. Effective management of the wetland for its nutrient trapping potential can be hindered by this oversimplification. The system is instead subject to relatively short-term alternation between net import and export. The periodic phosphorus export, although representing a small fraction of net annual import, could be critical for growth of macrophyte and algal communities downstream.

  10. Chamber QoE: a multi-instrumental approach to explore affective aspects in relation to quality of experience

    NASA Astrophysics Data System (ADS)

    De Moor, Katrien; Mazza, Filippo; Hupont, Isabelle; Ríos Quintero, Miguel; Mäki, Toni; Varela, Martín.

    2014-02-01

    Evaluating (audio)visual quality and Quality of Experience (QoE) from the user's perspective, has become a key element in optimizing users' experiences and their quality. Traditionally, the focus lies on how multi-level quality features are perceived by a human user. The interest has however gradually expanded towards human cognitive, affective and behavioral processes that may impact on, be an element of, or be influenced by QoE, and which have been underinvestigated so far. In addition, there is a major discrepancy between the new, broadly supported and more holistic conceptualization of QoE proposed by Le Callet et al. (2012) and traditional, standardized QoE assessment. This paper explores ways to tackle this discrepancy by means of a multi-instrumental approach. More concretely, it presents results from a lab study on video quality (N=27), aimed at going beyond the dominant QoE assessment paradigm and at exploring affective aspects in relation to QoE and in relation to perceived overall quality. Four types of data were collected: `traditional' QoE self-report measures were complemented with `alternative', emotional state- and user engagement-related self-report measures to evaluate QoE. In addition, we collected EEG (physiological) data, gazetracking data and facial expressions (behavioral) data. The video samples used in test were longer in duration than is common in standard tests allowing us to study e.g. more realistic experience and deeper user engagement. Our findings support the claim that the traditional QoE measures need to be reconsidered and extended with additional, affective staterelated measures.

  11. Bimodal loop-gap resonator

    NASA Astrophysics Data System (ADS)

    Piasecki, W.; Froncisz, W.; Hyde, James S.

    1996-05-01

    A bimodal loop-gap resonator for use in electron paramagnetic resonance (EPR) spectroscopy at S band is described. It consists of two identical one-loop-one-gap resonators in coaxial juxtaposition. In one mode, the currents in the two loops are parallel and in the other antiparallel. By introducing additional capacitors between the loops, the frequencies of the two modes can be made to coincide. Details are given concerning variable coupling to each mode, tuning of the resonant frequency of one mode to that of the other, and adjustment of the isolation between modes. An equivalent circuit is given and network analysis carried out both experimentally and theoretically. EPR applications are described including (a) probing of the field distributions with DPPH, (b) continuous wave (cw) EPR with a spin-label line sample, (c) cw electron-electron double resonance (ELDOR), (d) modulation of saturation, and (e) saturation-recovery (SR) EPR. Bloch induction experiments can be performed when the sample extends half way through the structure, but microwave signals induced by Mx and My components of magnetization cancel when it extends completely through. This latter situation is particularly favorable for SR, modulation of saturation, and ELDOR experiments, which depend on observing Mz indirectly using a second weak observing microwave source.

  12. Close-loop simulation of the medial olivocochlear anti-masking effects

    NASA Astrophysics Data System (ADS)

    Liu, Yi-Wen; Yu, Lu-Ming; Wu, Po-Jui

    2015-12-01

    The medial olivocochlear reflex (MOCR) is known to affect cochlear signal processing via the electromechanical changes it induces in outer hair cells (OHCs). Experiments showed that electrically stimulating the MOC efferents (i.e., open-loop stimulation) suppresses cochlear responses to acoustic noise while enhancing the response to tone bursts if the signal-to-noise ratio is sufficiently high [5]. However, such experiments did not reveal precisely how MOCR affects cochlear signal processing in a close loop. Presently we have built an integrated computer model for the MOCR pathway; the constituting sub-models include a model for cochlear mechanics with electromotile OHCs [11], a neurotransmitter release model for the synapse between inner hair cells (IHCs) and spiral ganglion cells [16], an electrical model for the T-multipolar (TM) cells in the cochlear nucleus [6], a relay from TM cells to the MOC interneurons, and a convolution kernel describing the change of OHC potassium conductance triggered by the MOC inhibitory post synaptic potentials. Thus, close-loop responses of the entire system can be simulated for arbitrary acoustic stimuli. Both open-loop and close-loop simulations demonstrate a decrease in the auditory nerve fiber (ANF) response to noise but an increase in the response to high-level tone bursts. The present integrated computer model can potentially be used for testing hypotheses regarding the physiological mechanisms for MOC anti-masking effects.

  13. Individual experience and evolutionary history of predation affect expression of heritable variation in fish personality and morphology.

    PubMed

    Dingemanse, Niels J; Van der Plas, Fons; Wright, Jonathan; Réale, Denis; Schrama, Maarten; Roff, Derek A; Van der Zee, Els; Barber, Iain

    2009-04-07

    Predation plays a central role in evolutionary processes, but little is known about how predators affect the expression of heritable variation, restricting our ability to predict evolutionary effects of predation. We reared families of three-spined stickleback Gasterosteus aculeatus from two populations-one with a history of fish predation (predator sympatric) and one without (predator naive)-and experimentally manipulated experience of predators during ontogeny. For a suite of ecologically relevant behavioural ('personality') and morphological traits, we then estimated two key variance components, additive genetic variance (VA) and residual variance (VR), that jointly shape narrow-sense heritability (h2=VA/(VA+VR)). Both population and treatment differentially affected VA versus VR, hence h2, but only for certain traits. The predator-naive population generally had lower VA and h2 values than the predator-sympatric population for personality behaviours, but not morphological traits. Values of VR and h2 were increased for some, but decreased for other personality traits in the predator-exposed treatment. For some personality traits, VA and h2 values were affected by treatment in the predator-naive population, but not in the predator-sympatric population, implying that the latter harboured less genetic variation for behavioural plasticity. Replication and experimental manipulation of predation regime are now needed to confirm that these population differences were related to variation in predator-induced selection. Cross-environment genetic correlations (rA) were tight for most traits, suggesting that predator-induced selection can affect the evolution of the same trait expressed in the absence of predators. The treatment effects on variance components imply that predators can affect evolution, not only by acting directly as selective agents, but also by influencing the expression of heritable variation.

  14. Loop quantum cosmology gravitational baryogenesis

    NASA Astrophysics Data System (ADS)

    Odintsov, S. D.; Oikonomou, V. K.

    2016-11-01

    Loop quantum cosmology is an appealing quantum completion of classical cosmology, which brings along various theoretical features which in many cases offer a remedy for or modify various classical cosmology aspects. In this paper we address the gravitational baryogenesis mechanism in the context of loop quantum cosmology. As we demonstrate, when loop quantum cosmology effects are taken into account in the resulting Friedmann equations for a flat Friedmann-Robertson-Walker Universe, then even for a radiation-dominated Universe, the predicted baryon-to-entropy ratio from the gravitational baryogenesis mechanism is non-zero, in contrast to the Einstein-Hilbert case, in which case the baryon-to-entropy ratio is zero. We also discuss various other cases apart from the radiation domination case, and we discuss how the baryon-to-entropy ratio is affected from the parameters of the quantum theory. In addition, we use illustrative exact solutions of loop quantum cosmology and we investigate under which circumstances the baryon-to-entropy ratio can be compatible with the observational constraints.

  15. Researchers' choice of the number and range of levels in experiments affects the resultant variance-accounted-for effect size.

    PubMed

    Okada, Kensuke; Hoshino, Takahiro

    2016-08-08

    In psychology, the reporting of variance-accounted-for effect size indices has been recommended and widely accepted through the movement away from null hypothesis significance testing. However, most researchers have paid insufficient attention to the fact that effect sizes depend on the choice of the number of levels and their ranges in experiments. Moreover, the functional form of how and how much this choice affects the resultant effect size has not thus far been studied. We show that the relationship between the population effect size and number and range of levels is given as an explicit function under reasonable assumptions. Counterintuitively, it is found that researchers may affect the resultant effect size to be either double or half simply by suitably choosing the number of levels and their ranges. Through a simulation study, we confirm that this relation also applies to sample effect size indices in much the same way. Therefore, the variance-accounted-for effect size would be substantially affected by the basic research design such as the number of levels. Simple cross-study comparisons and a meta-analysis of variance-accounted-for effect sizes would generally be irrational unless differences in research designs are explicitly considered.

  16. Glycoprotein Degradation in the Blind Loop Syndrome

    PubMed Central

    Prizont, Roberto

    1981-01-01

    Contents obtained from jejunum of normal controls, self-emptying and self-filling blind loop rats were analyzed for the presence of glycoprotein-degrading glycosidases. The blind loop syndrome was documented by the increased fat excretion and slower growth rate of self-filling blind loop rats 6 wk after surgery. With p-nitrophenylglycosides as substrate, the specific activity of α-N-acetylgalactosaminidase, a potential blood group A destroying glycosidase, was 0.90±0.40 mU/mg of protein. This level was 23-fold higher than the specific activity of normal controls. In partially purified self-filling blind loop contents, the activity of α-N-acetylgalactosaminidase was 9- to 70-fold higher than activities of self-emptying and normal controls. Antibiotic treatment with chloromycetin and polymyxin decreased 24-fold the glycosidase levels in self-filling blind loops. In experiments with natural substrate, the blood group A titer of a20,000g supernate from normal jejunal homogenates decreased 128-fold after 24-h incubation with blind loop contents. Normal contents failed to diminish the blood group reactivity of the natural substrate. Furthermore, blind loop contents markedly decreased the blood group A titer of isolated brush borders. Incubation between blind loop bacteria and mucosal homogenates or isolated brush borders labeled with d-[U-14C]glucosamine revealed increased production of labeled ether extractable organic acids. Likewise, intraperitoneal injection of d-[U-14C]glucosamine into self-filling blind loop rats resulted in incorporation of the label into luminal short chain fatty acids. These results suggest that glycosidases may provide a mechanism by which blind loop bacteria obtain sugars from intestinal glycoproteins. The released sugars are used and converted by bacteria into energy and organic acids. This use of the host's glycoproteins would allow blind loop bacteria to grow and survive within the lumen independent of exogenous sources. PMID:6257760

  17. Formation of Chromosomal Domains by Loop Extrusion.

    PubMed

    Fudenberg, Geoffrey; Imakaev, Maxim; Lu, Carolyn; Goloborodko, Anton; Abdennur, Nezar; Mirny, Leonid A

    2016-05-31

    Topologically associating domains (TADs) are fundamental structural and functional building blocks of human interphase chromosomes, yet the mechanisms of TAD formation remain unclear. Here, we propose that loop extrusion underlies TAD formation. In this process, cis-acting loop-extruding factors, likely cohesins, form progressively larger loops but stall at TAD boundaries due to interactions with boundary proteins, including CTCF. Using polymer simulations, we show that this model produces TADs and finer-scale features of Hi-C data. Each TAD emerges from multiple loops dynamically formed through extrusion, contrary to typical illustrations of single static loops. Loop extrusion both explains diverse experimental observations-including the preferential orientation of CTCF motifs, enrichments of architectural proteins at TAD boundaries, and boundary deletion experiments-and makes specific predictions for the depletion of CTCF versus cohesin. Finally, loop extrusion has potentially far-ranging consequences for processes such as enhancer-promoter interactions, orientation-specific chromosomal looping, and compaction of mitotic chromosomes.

  18. Assessing metacognitive skills in waking and sleep: a psychometric analysis of the Metacognitive, Affective, Cognitive Experience (MACE) questionnaire.

    PubMed

    Kahan, Tracey L; Sullivan, Kieran T

    2012-03-01

    The Metacognitive, Affective, Cognitive Experience (MACE) questionnaire was designed to assess metacognition across sleep and waking (Kahan & LaBerge, 1996). The present research evaluates the psychometric properties of the MACE. Data from two recent studies (N=185) were used to assess the inter-item consistency, test-retest reliability, and factorial, convergent, and discriminant validity of the MACE. Results show that the MACE is a reliable measure with good construct validity. Exploratory factor analyses revealed one self-regulation and two monitoring factors. One monitoring factor emphasized monitoring internal conditions; the other emphasized monitoring external conditions. This factor structure is consistent with the Metacognitive Model (Nelson & Narens, 1990). Tests of convergent and discriminant validity suggest that the MACE is assessing metacognition and is appropriately related to similar constructs such as mindfulness and self-consciousness. The implication of these findings as well as suggestions for research and clinical applications of the MACE are discussed.

  19. Grain boundary loops in graphene

    NASA Astrophysics Data System (ADS)

    Cockayne, Eric; Rutter, Gregory M.; Guisinger, Nathan P.; Crain, Jason N.; First, Phillip N.; Stroscio, Joseph A.

    2011-05-01

    Topological defects can affect the physical properties of graphene in unexpected ways. Harnessing their influence may lead to enhanced control of both material strength and electrical properties. Here we present a class of topological defects in graphene composed of a rotating sequence of dislocations that close on themselves, forming grain boundary loops that either conserve the number of atoms in the hexagonal lattice or accommodate vacancy or interstitial reconstruction, while leaving no unsatisfied bonds. One grain boundary loop is observed as a “flower” pattern in scanning tunneling microscopy studies of epitaxial graphene grown on SiC(0001). We show that the flower defect has the lowest energy per dislocation core of any known topological defect in graphene, providing a natural explanation for its growth via the coalescence of mobile dislocations.

  20. Detecting neutrino magnetic moments with conducting loops

    NASA Astrophysics Data System (ADS)

    Apyan, Aram; Apyan, Armen; Schmitt, Michael

    2008-02-01

    It is well established that neutrinos have mass, yet it is very difficult to measure those masses directly. Within the standard model of particle physics, neutrinos will have an intrinsic magnetic moment proportional to their mass. We examine the possibility of detecting the magnetic moment using a conducting loop. According to Faraday’s law of induction, a magnetic dipole passing through a conducting loop induces an electromotive force in the loop. We compute this electromotive force for neutrinos in several cases, based on a fully covariant formulation of the problem. We discuss prospects for a real experiment, as well as the possibility to test the relativistic formulation of intrinsic magnetic moments.

  1. Hardware-in-the-loop simulation experiment for semi-active vibration control of lateral vibrations of railway vehicle by magneto-rheological fluid damper

    NASA Astrophysics Data System (ADS)

    Kwak, Moon K.; Lee, Jae-Ha; Yang, Dong-Ho; You, Won-Hee

    2014-07-01

    The active lateral suspension (ALS) of a train consists of either active or semi-active technologies. However, such an active system on a real railway vehicle is not easy to test because of cost and time. In this study, a hardware-in-the-loop simulation (HILS) system is developed to test the ALS. To this end, the dynamic model of a railway vehicle is equipped with the actuator, two bogies and four-wheel sets, and the ALS is used. The proposed HILS system consists of an alternating current servo motor connected to a ball-screw mechanism and a digital control system. The digital control system implements the dynamic model and the control algorithm. The design and manufacture of the HILS system are explained in detail. Both the passive damper and the magneto-rheological (MR) fluid damper are tested using the HILS system, where the sky-hook control algorithm was applied for the MR fluid damper. Experimental results show that the proposed HILS system can be effectively used for the performance estimation of the ALS.

  2. Experience of affects predicting sense of self and others in short-term dynamic and cognitive therapy.

    PubMed

    Berggraf, Lene; Ulvenes, Pål G; Oktedalen, Tuva; Hoffart, Asle; Stiles, Tore; McCullough, Leigh; Wampold, Bruce E

    2014-06-01

    The present study examined whether levels of activating affects (AA) and inhibitory affects (IA) were related to change toward more compassionate and realistic levels of sense of self (SoS) and sense of others (SoO). The sample included 47 patients diagnosed with cluster C personality disorders, who received 40 sessions of either cognitive therapy or short-term dynamic therapy (see the randomized controlled trial study, Svartberg, Stiles, & Seltzer, 2004). A total of 927 videotaped sessions were rated with the use of the observational instrument, Achievement of Therapeutic Objectives Scale. Longitudinal multilevel modeling enabled the examination of both between-person effects and within-person changes in level of AA and IA. Patients with better ability to experience AA at the start of therapy displayed significantly higher SoS and SoO across sessions compared with other patients. Patients who experienced higher levels of IA at the start of therapy displayed lower levels of SoS across sessions. A patient experiencing more AA than usual for him/her self within a session predicted an increased level of SoS and SoO at the next measuring point. There were no different change patterns in the 2 treatment groups. Results suggest that focus within therapy sessions on increasing patients' AA can help facilitate change in SoS and SoO toward more compassionate and realistic quality.

  3. Decisions at the Brink: Locomotor Experience Affects Infants' Use of Social Information on an Adjustable Drop-off.

    PubMed

    Karasik, Lana B; Tamis-LeMonda, Catherine S; Adolph, Karen E

    2016-01-01

    How do infants decide what to do at the brink of a precipice? Infants could use two sources of information to guide their actions: perceptual information generated by their own exploratory activity and social information offered by their caregivers. The current study investigated the role of locomotor experience in using social information-both encouragement and discouragement-for descending drop-offs. Mothers of 30 infants (experienced 12-month-old crawlers, novice 12-month-old walkers, and experienced 18-month-old walkers) encouraged and discouraged descent on a gradation of drop-offs (safe "steps" and risky "cliffs"). Novice walkers descended more frequently than experienced crawlers and walkers and fell while attempting to walk over impossibly high cliffs. All infants showed evidence of integrating perceptual and social information, but locomotor experience affected infants' use of social messages, especially on risky drop-offs. Experienced crawlers and walkers selectively deferred to social information when perceptual information is ambiguous. In contrast, novice walkers took mothers' advice inconsistently and only at extreme drop-offs.

  4. Optimization of parameters affecting signal intensity in an LTQ-orbitrap in negative ion mode: A design of experiments approach.

    PubMed

    Lemonakis, Nikolaos; Skaltsounis, Alexios-Leandros; Tsarbopoulos, Anthony; Gikas, Evagelos

    2016-01-15

    A multistage optimization of all the parameters affecting detection/response in an LTQ-orbitrap analyzer was performed, using a design of experiments methodology. The signal intensity, a critical issue for mass analysis, was investigated and the optimization process was completed in three successive steps, taking into account the three main regions of an orbitrap, the ion generation, the ion transmission and the ion detection regions. Oleuropein and hydroxytyrosol were selected as the model compounds. Overall, applying this methodology the sensitivity was increased more than 24%, the resolution more than 6.5%, whereas the elapsed scan time was reduced nearly to its half. A high-resolution LTQ Orbitrap Discovery mass spectrometer was used for the determination of the analytes of interest. Thus, oleuropein and hydroxytyrosol were infused via the instruments syringe pump and they were analyzed employing electrospray ionization (ESI) in the negative high-resolution full-scan ion mode. The parameters of the three main regions of the LTQ-orbitrap were independently optimized in terms of maximum sensitivity. In this context, factorial design, response surface model and Plackett-Burman experiments were performed and analysis of variance was carried out to evaluate the validity of the statistical model and to determine the most significant parameters for signal intensity. The optimum MS conditions for each analyte were summarized and the method optimum condition was achieved by maximizing the desirability function. Our observation showed good agreement between the predicted optimum response and the responses collected at the predicted optimum conditions.

  5. Breeding experience and population density affect the ability of a songbird to respond to future climate variation

    PubMed Central

    Wilson, Scott; Norris, D. Ryan; Wilson, Amy G; Arcese, Peter

    2007-01-01

    Predicting how populations respond to climate change requires an understanding of whether individuals or cohorts within populations vary in their response to climate variation. We used mixed-effects models on a song sparrow (Melospiza melodia) population in British Columbia, Canada, to examine differences among females and cohorts in their average breeding date and breeding date plasticity in response to the El Niño Southern Oscillation. Climatic variables, age and population density were strong predictors of timing of breeding, but we also found considerable variation among individual females and cohorts. Within cohorts, females differed markedly in their breeding date and cohorts also differed in their average breeding date and breeding date plasticity. The plasticity of a cohort appeared to be due primarily to an interaction between the environmental conditions (climate and density) experienced at different ages rather than innate inter-cohort differences. Cohorts that expressed higher plasticity in breeding date experienced warmer El Niño springs in their second or third breeding season, suggesting that prior experience affects how well individuals responded to abnormal climatic conditions. Cohorts born into lower density populations also expressed higher plasticity in breeding date. Interactions between age, experience and environmental conditions have been reported previously for long-lived taxa. Our current results indicate that similar effects operate in a short-lived, temperate songbird. PMID:17698488

  6. Decisions at the Brink: Locomotor Experience Affects Infants’ Use of Social Information on an Adjustable Drop-off

    PubMed Central

    Karasik, Lana B.; Tamis-LeMonda, Catherine S.; Adolph, Karen E.

    2016-01-01

    How do infants decide what to do at the brink of a precipice? Infants could use two sources of information to guide their actions: perceptual information generated by their own exploratory activity and social information offered by their caregivers. The current study investigated the role of locomotor experience in using social information—both encouragement and discouragement—for descending drop-offs. Mothers of 30 infants (experienced 12-month-old crawlers, novice 12-month-old walkers, and experienced 18-month-old walkers) encouraged and discouraged descent on a gradation of drop-offs (safe “steps” and risky “cliffs”). Novice walkers descended more frequently than experienced crawlers and walkers and fell while attempting to walk over impossibly high cliffs. All infants showed evidence of integrating perceptual and social information, but locomotor experience affected infants’ use of social messages, especially on risky drop-offs. Experienced crawlers and walkers selectively deferred to social information when perceptual information is ambiguous. In contrast, novice walkers took mothers’ advice inconsistently and only at extreme drop-offs. PMID:27375507

  7. Do you see what I see? The difference between dog and human visual perception may affect the outcome of experiments.

    PubMed

    Pongrácz, Péter; Ujvári, Vera; Faragó, Tamás; Miklósi, Ádám; Péter, András

    2017-04-07

    The visual sense of dogs is in many aspects different than that of humans. Unfortunately, authors do not explicitly take into consideration dog-human differences in visual perception when designing their experiments. With an image manipulation program we altered stationary images, according to the present knowledge about dog-vision. Besides the effect of dogs' dichromatic vision, the software shows the effect of the lower visual acuity and brightness discrimination, too. Fifty adult humans were tested with pictures showing a female experimenter pointing, gazing or glancing to the left or right side. Half of the pictures were shown after they were altered to a setting that approximated dog vision. Participants had difficulty to find out the direction of glancing when the pictures were in dog-vision mode. Glances in dog-vision setting were followed less correctly and with a slower response time than other cues. Our results are the first that show the visual performance of humans under circumstances that model how dogs' weaker vision would affect their responses in an ethological experiment. We urge researchers to take into consideration the differences between perceptual abilities of dogs and humans, by developing visual stimuli that fit more appropriately to dogs' visual capabilities.

  8. Are People Emotionally Predisposed to Experience Lower Quality of Life? The Impact of Negative Affectivity on Quality of Life in Patients Recovering from Cardiac Surgery

    ERIC Educational Resources Information Center

    Panagopoulou, Efharis; Montgomery, Anthony J.; Benos, Alexis; Maes, Stan

    2006-01-01

    Negative affectivity has been defined as a predisposition to experience intense states of negative emotions. As a trait concept it is a dimension that reflects stable and pervasive differences in negative mood and self-concept. There has been systematic evidence linking negative affectivity to anxiety, depression, psychosomatic complaints, pain…

  9. Does Vicarious Experience of Suffering Affect Empathy for an Adversary? The Effects of Israelis' Visits to Auschwitz on Their Empathy for Palestinians

    ERIC Educational Resources Information Center

    Shechter, Hava; Salomon, Gavriel

    2005-01-01

    Empathy for the adversary is part of peace education. Does the vicarious experience of suffering affect empathy towards the suffering of an adversary? Specifically, does the visit of Israeli youth to Auschwitz affect their empathy toward the Palestinians? Three hundred and nine high school students participated in the study: One half went on the…

  10. A magnetohydrodynamic theory of coronal loop transients

    NASA Technical Reports Server (NTRS)

    Yeh, T.

    1982-01-01

    The physical and geometrical characteristics of solar coronal loop transients are described in an MHD model based on Archimedes' MHD buoyancy force. The theory was developed from interpretation of coronagraphic data, particularly from Skylab. The brightness of a loop is taken to indicate the electron density, and successive pictures reveal the electron enhancement in different columns. The forces which lift the loop off the sun surface are analyzed as an MHD buoyancy force affecting every mass element by imparting an inertial force necessary for heliocentrifugal motion. Thermal forces are responsible for transferring the ambient stress to the interior of the loop to begin the process. The kinematic and hydrostatic buoyancy overcome the gravitational force, and a flux rope can then curve upward, spiralling like a corkscrew with varying cross section around the unwinding solar magnetic field lines.

  11. Loss of Rare Fish Species from Tropical Floodplain Food Webs Affects Community Structure and Ecosystem Multifunctionality in a Mesocosm Experiment

    PubMed Central

    Pendleton, Richard M.; Hoeinghaus, David J.; Gomes, Luiz C.; Agostinho, Angelo A.

    2014-01-01

    Experiments with realistic scenarios of species loss from multitrophic ecosystems may improve insight into how biodiversity affects ecosystem functioning. Using 1000 L mesocoms, we examined effects of nonrandom species loss on community structure and ecosystem functioning of experimental food webs based on multitrophic tropical floodplain lagoon ecosystems. Realistic biodiversity scenarios were developed based on long-term field surveys, and experimental assemblages replicated sequential loss of rare species which occurred across all trophic levels of these complex food webs. Response variables represented multiple components of ecosystem functioning, including nutrient cycling, primary and secondary production, organic matter accumulation and whole ecosystem metabolism. Species richness significantly affected ecosystem function, even after statistically controlling for potentially confounding factors such as total biomass and direct trophic interactions. Overall, loss of rare species was generally associated with lower nutrient concentrations, phytoplankton and zooplankton densities, and whole ecosystem metabolism when compared with more diverse assemblages. This pattern was also observed for overall ecosystem multifunctionality, a combined metric representing the ability of an ecosystem to simultaneously maintain multiple functions. One key exception was attributed to time-dependent effects of intraguild predation, which initially increased values for most ecosystem response variables, but resulted in decreases over time likely due to reduced nutrient remineralization by surviving predators. At the same time, loss of species did not result in strong trophic cascades, possibly a result of compensation and complexity of these multitrophic ecosystems along with a dominance of bottom-up effects. Our results indicate that although rare species may comprise minor components of communities, their loss can have profound ecosystem consequences across multiple trophic

  12. Loss of rare fish species from tropical floodplain food webs affects community structure and ecosystem multifunctionality in a mesocosm experiment.

    PubMed

    Pendleton, Richard M; Hoeinghaus, David J; Gomes, Luiz C; Agostinho, Angelo A

    2014-01-01

    Experiments with realistic scenarios of species loss from multitrophic ecosystems may improve insight into how biodiversity affects ecosystem functioning. Using 1000 L mesocoms, we examined effects of nonrandom species loss on community structure and ecosystem functioning of experimental food webs based on multitrophic tropical floodplain lagoon ecosystems. Realistic biodiversity scenarios were developed based on long-term field surveys, and experimental assemblages replicated sequential loss of rare species which occurred across all trophic levels of these complex food webs. Response variables represented multiple components of ecosystem functioning, including nutrient cycling, primary and secondary production, organic matter accumulation and whole ecosystem metabolism. Species richness significantly affected ecosystem function, even after statistically controlling for potentially confounding factors such as total biomass and direct trophic interactions. Overall, loss of rare species was generally associated with lower nutrient concentrations, phytoplankton and zooplankton densities, and whole ecosystem metabolism when compared with more diverse assemblages. This pattern was also observed for overall ecosystem multifunctionality, a combined metric representing the ability of an ecosystem to simultaneously maintain multiple functions. One key exception was attributed to time-dependent effects of intraguild predation, which initially increased values for most ecosystem response variables, but resulted in decreases over time likely due to reduced nutrient remineralization by surviving predators. At the same time, loss of species did not result in strong trophic cascades, possibly a result of compensation and complexity of these multitrophic ecosystems along with a dominance of bottom-up effects. Our results indicate that although rare species may comprise minor components of communities, their loss can have profound ecosystem consequences across multiple trophic

  13. Multiprotein DNA Looping

    NASA Astrophysics Data System (ADS)

    Vilar, Jose M. G.; Saiz, Leonor

    2006-06-01

    DNA looping plays a fundamental role in a wide variety of biological processes, providing the backbone for long range interactions on DNA. Here we develop the first model for DNA looping by an arbitrarily large number of proteins and solve it analytically in the case of identical binding. We uncover a switchlike transition between looped and unlooped phases and identify the key parameters that control this transition. Our results establish the basis for the quantitative understanding of fundamental cellular processes like DNA recombination, gene silencing, and telomere maintenance.

  14. Hexachlorobenzene dechlorination as affected by organic fertilizer and urea applications in two rice planted paddy soils in a pot experiment.

    PubMed

    Liu, C Y; Jiang, X; Yang, X L; Song, Y

    2010-01-15

    Reductive dechlorination is a crucial pathway for HCB degradation, the applications of organic materials and nitrogen can alter microbial activity and redox potential of soils, thus probably influence HCB dechlorination. To evaluate hexachlorobenzene (HCB) dechlorination as affected by organic fertilizer (OF) and urea applications in planted paddy soils, a pot experiment was conducted in two types of soils, Hydragric Acrisols (Ac) and Gleyi-Stagnic Anthrosols (An). After 18 weeks of experiment, HCB residues decreased by 28.2-37.5% of the initial amounts in Ac, and 42.1-70.9% in An. The amounts of HCB metabolites showed that dechlorination rates in An were higher than in Ac, which was mainly attributed to the higher pH and dissolved organic carbon (DOC) content of An. Both in Ac and An, the additions of 1% and 2% OF had negative effect on HCB dechlorination, which was probably because excessive nitrogen in OF decreased degraders' activity and the degradation of organic carbon in OF accepted electrons. The application of 0.03% urea could enhance HCB dechlorination rates slightly, while 0.06% urea accelerated HCB dechlorination significantly both in Ac and An. It could be assumed that urea served as an electron donor and stimulated degraders to dechlorinate HCB. In addition, the methanogenic bacteria were involved in dechlorination process, and reductive dechlorination in planted paddy soil might be impeded for the aerenchyma and O(2) supply into the rhizosphere. Results indicated that soil types, rice root system, methanogenic bacteria, OF and urea applications all had great effects on dechlorination process.

  15. Introduction to Loop Heat Pipes

    NASA Technical Reports Server (NTRS)

    Ku, Jentung

    2015-01-01

    This is the presentation file for the short course Introduction to Loop Heat Pipes, to be conducted at the 2015 Thermal Fluids and Analysis Workshop, August 3-7, 2015, Silver Spring, Maryland. This course will discuss operating principles and performance characteristics of a loop heat pipe. Topics include: 1) pressure profiles in the loop; 2) loop operating temperature; 3) operating temperature control; 4) loop startup; 4) loop shutdown; 5) loop transient behaviors; 6) sizing of loop components and determination of fluid inventory; 7) analytical modeling; 8) examples of flight applications; and 9) recent LHP developments.

  16. Ultraviolet plumage ornamentation affects social mate choice and sperm competition in bluethroats (Aves: Luscinia s. svecica): a field experiment

    PubMed Central

    Johnsen, A.; Andersson, S.; rnborg, J.; Lifjeld, J. T.

    1998-01-01

    The blue throat feathers of male bluethroats (Luscinia s. svecica) show a reflectance peak in the ultraviolet (UV) waveband (320 to 400 nm). The throat is actively displayed during courtship, suggesting a role for sexual selection on an ultraviolet signal. Indeed, a recent aviary experiment demonstrated that females discriminated against males with artificially reduced UV reflectance (Andersson and Amundsen 1997). Here, we report the results of a similar experimental manipulation applied on free-ranging males. UV-reduced (UVR) males had a lower success in attracting mates, as judged from a significantly later start of egg laying, compared with control (C) males. UVR males also spent significantly less time advertising for additional mates when their own mate was fertile, and they had a lower success in achieving extra-pair fertilizations. Furthermore, UVR males tended to guard their mates more closely and lose more paternity in their own brood than C males did. We conclude that the treatment affected both social and extra-pair mate choice. This is the first experimental evidence that UV signalling influences male mating success in free-ranging birds.

  17. Evaluation of the legal consequences of action affects neural activity and emotional experience during the resolution of moral dilemmas.

    PubMed

    Pletti, Carolina; Sarlo, Michela; Palomba, Daniela; Rumiati, Rino; Lotto, Lorella

    2015-03-01

    In any modern society killing is regarded as a severe violation of the legal codes that is subjected to penal judgment. Therefore, it is likely that people take legal consequences into account when deciding about the hypothetical killing of one person in classic moral dilemmas, with legal concerns contributing to decision-making. In particular, by differing for the degree of intentionality and emotional salience, Footbridge- and Trolley-type dilemmas might promote differential assignment of blame and punishment while implicating the same severity of harm. The present study was aimed at comparing the neural activity, subjective emotional reactions, and behavioral choices in two groups of participants who either took (Legal group) or did not take (No Legal group) legal consequences into account when deciding on Footbridge-type and Trolley-type moral dilemmas. Stimulus- and response-locked ERPs were measured to investigate the neural activity underlying two separate phases of the decision process. No difference in behavioral choices was found between groups. However, the No Legal group reported greater overall emotional impact, associated with lower preparation for action, suggesting greater conflict between alternative motor responses representing the different decision choices. In contrast, the Legal group showed an overall dampened affective experience during decision-making associated with greater overall action readiness and intention to act, reflecting lower conflict in responding. On these bases, we suggest that in moral dilemmas legal consequences of actions provide a sort of reference point on which people can rely to support a decision, independent of dilemma type.

  18. Factors affecting the views and experiences of women living in the city centre of Manisa, Turkey, regarding domestic violence.

    PubMed

    2015-09-21

    Domestic violence against women is an important social and public health problem worldwide resulting from unequal power relationships between men and women. The purpose of the present cross-sectional descriptive study was to determine the factors affecting the views and experiences of women living in the city centre of Manisa, Turkey, regarding domestic violence. The data were collected from a representative sample of women (n = 873) in 2012. The socio-demographic questionnaire and the World Health Organization's Multi-country Study on Women's Health and Domestic Violence Against Women were used for data collection. The study results revealed that of the women, 14.8% were exposed to physical violence, 7.9% to sexual violence, 20.2% to emotional violence/abuse and 11.2% to economic violence/abuse within the last 12 months. Lower income level, lower social status, lower educational level, unemployment, being exposed to parental violence during childhood and being married to husbands exposed to parental violence during childhood were associated risk factors with domestic violence. The study results indicate that domestic violence against women is a common phenomenon in Manisa.

  19. Do benefits in kind or refunds affect health service utilization and health outcomes? A natural experiment from Japan.

    PubMed

    Takaku, Reo; Bessho, Shun-Ichiro

    2017-03-12

    Although the payment systems of public health insurance vary greatly across countries, we still have limited knowledge of their effects. To quantify the changes from a benefits in kind system to a refund system, we exploit the largest physician strike in Japan since the Second World War. During the strike in 1971 led by the Japan Medical Association (JMA), JMA physicians resigned as health insurance doctors, but continued to provide medical care and even health insurance treatment in some areas. This study uses the regional differences in resignation rates as a natural experiment to examine the effect of the payment method of health insurance on medical service utilization and health outcomes. In the main analysis, aggregated monthly prefectural data are used (N=46). Our estimation results indicate that if the participation rate of the strike had increased by 1% point and proxy claims were refused completely, the number of cases of insurance benefits and the total amount of insurance benefits would have decreased by 0.78% and 0.58%, respectively compared with the same month in the previous year. Moreover, the average amount of insurance benefits per claim increased since patients with relatively less serious diseases might have sought health care less often. Finally, our results suggest that the mass of resignations did not affect death rates.

  20. Explaining Warm Coronal Loops

    NASA Technical Reports Server (NTRS)

    Klimchuk, James A.; Karpen, Judy T.; Patsourakos, Spiros

    2008-01-01

    One of the great mysteries of coronal physics that has come to light in the last few years is the discovery that warn (- 1 INK) coronal loops are much denser than expected for quasi-static equilibrium. Both the excess densities and relatively long lifetimes of the loops can be explained with bundles of unresolved strands that are heated impulsively to very high temperatures. Since neighboring strands are at different stages of cooling, the composite loop bundle is multi-thermal, with the distribution of temperatures depending on the details of the "nanoflare storm." Emission hotter than 2 MK is predicted, but it is not clear that such emission is always observed. We consider two possible explanations for the existence of over-dense warm loops without corresponding hot emission: (1) loops are bundles of nanoflare heated strands, but a significant fraction of the nanoflare energy takes the form of a nonthermal electron beam rather then direct plasma heating; (2) loops are bundles of strands that undergo thermal nonequilibrium that results when steady heating is sufficiently concentrated near the footpoints. We present numerical hydro simulations of both of these possibilities and explore the observational consequences, including the production of hard X-ray emission and absorption by cool material in the corona.

  1. DNA Looping, Supercoiling and Tension

    NASA Astrophysics Data System (ADS)

    Finzi, Laura

    2007-11-01

    In complex organisms, activation or repression of gene expression by proteins bound to enhancer or silencer elements located several kilobases away from the promoter is a well recognized phenomenon. However, a mechanistic understanding of any of these multiprotein interactions is still incomplete. Part of the difficulty in characterizing long-range interactions is the complexity of the regulatory systems and also an underestimation of the effect of DNA supercoiling and tension. Supercoiling is expected to promote interactions between DNA sites because it winds the DNA into compact plectonemes in which distant DNA segments more frequently draw close. The idea that DNA is also under various levels of tension is becoming more widely accepted. Forces that stretch the double helix in vivo are the electrostatic repulsion among the negatively charged phosphate groups along the DNA backbone, the action of motor enzymes perhaps acting upon a topologically constrained sequence of DNA or chromosome segregation during cell mitosis following DNA replication. Presently, little is known about the tension acting on DNA in vivo, but characterization of how physiological regulatory processes, such as loop formation, depend on DNA tension in vitro will indicate the stretching force regimes likely to exist in vivo. In this light, the well studied CI protein of bacteriophage l, which was recently found to cause a of 3.8 kbp loop in DNA, is an ideal system in which to characterize long-range gene regulation. The large size of the loop lends itself to single-molecule techniques, which allow characterization of the dynamics of CI-mediated l DNA looping under controlled levels of supercoiling and tension. Such experiments are being used to discover the principles of long-range interactions in l and in more complex systems.

  2. Decay-less kink oscillations in coronal loops

    NASA Astrophysics Data System (ADS)

    Anfinogentov, S.; Nisticò, G.; Nakariakov, V. M.

    2013-12-01

    Context. Kink oscillations of coronal loops in an off-limb active region are detected with the Imaging Assembly Array (AIA) instruments of the Solar Dynamics Observatory (SDO) at 171 Å. Aims: We aim to measure periods and amplitudes of kink oscillations of different loops and to determinate the evolution of the oscillation phase along the oscillating loop. Methods: Oscillating coronal loops were visually identified in the field of view of SDO/AIA and STEREO/EUVI-A: the loop length was derived by three-dimensional analysis. Several slits were taken along the loops to assemble time-distance maps. We identified oscillatory patterns and retrieved periods and amplitudes of the oscillations. We applied the cross-correlation technique to estimate the phase shift between oscillations at different segments of oscillating loops. Results: We found that all analysed loops show low-amplitude undamped transverse oscillations. Oscillation periods of loops in the same active region range from 2.5 to 11 min, and are different for different loops. The displacement amplitude is lower than 1 Mm. The oscillation phase is constant along each analysed loop. The spatial structure of the phase of the oscillations corresponds to the fundamental standing kink mode. We conclude that the observed behaviour is consistent with the empirical model in terms of a damped harmonic resonator affected by a non-resonant continuously operating external force. A movie is available in electronic form at http://www.aanda.org

  3. Mutation of mapped TIA-1/TIAR binding sites in the 3' terminal stem-loop of West Nile virus minus-strand RNA in an infectious clone negatively affects genomic RNA amplification.

    PubMed

    Emara, Mohamed M; Liu, Hsuan; Davis, William G; Brinton, Margo A

    2008-11-01

    Previous data showed that the cellular proteins TIA-1 and TIAR bound specifically to the West Nile virus 3' minus-strand stem-loop [WNV3'(-)SL] RNA (37) and colocalized with flavivirus replication complexes in WNV- and dengue virus-infected cells (21). In the present study, the sites on the WNV3'(-)SL RNA required for efficient in vitro T-cell intracellular antigen-related (TIAR) and T-cell intracellular antigen-1 (TIA-1) protein binding were mapped to short AU sequences (UAAUU) located in two internal loops of the WNV3'(-)SL RNA structure. Infectious clone RNAs with all or most of the binding site nucleotides in one of the 3' (-)SL loops deleted or substituted did not produce detectable virus after transfection or subsequent passage. With one exception, deletion/mutation of a single terminal nucleotide in one of the binding sequences had little effect on the efficiency of protein binding or virus production, but mutation of a nucleotide in the middle of a binding sequence reduced both the in vitro protein binding efficiency and virus production. Plaque size, intracellular genomic RNA levels, and virus production progressively decreased with decreasing in vitro TIAR/TIA-1 binding activity, but the translation efficiency of the various mutant RNAs was similar to that of the parental RNA. Several of the mutant RNAs that inefficiently interacted with TIAR/TIA-1 in vitro rapidly reverted in vivo, indicating that they could replicate at a low level and suggesting that an interaction between TIAR/TIA-1 and the viral 3'(-)SL RNA is not required for initial low-level symmetric RNA replication but instead facilitates the subsequent asymmetric amplification of genome RNA from the minus-strand template.

  4. Changing nutrient stoichiometry affects phytoplankton production, DOP accumulation and dinitrogen fixation - a mesocosm experiment in the eastern tropical North Atlantic

    NASA Astrophysics Data System (ADS)

    Meyer, J.; Löscher, C. R.; Neulinger, S. C.; Reichel, A. F.; Loginova, A.; Borchard, C.; Schmitz, R. A.; Hauss, H.; Kiko, R.; Riebesell, U.

    2016-02-01

    Ocean deoxygenation due to climate change may alter redox-sensitive nutrient cycles in the marine environment. The productive eastern tropical North Atlantic (ETNA) upwelling region may be particularly affected when the relatively moderate oxygen minimum zone (OMZ) deoxygenates further and microbially driven nitrogen (N) loss processes are promoted. Consequently, water masses with a low nitrogen to phosphorus (N : P) ratio could reach the euphotic layer, possibly influencing primary production in those waters. Previous mesocosm studies in the oligotrophic Atlantic Ocean identified nitrate availability as a control of primary production, while a possible co-limitation of nitrate and phosphate could not be ruled out. To better understand the impact of changing N : P ratios on primary production and N2 fixation in the ETNA surface ocean, we conducted land-based mesocosm experiments with natural plankton communities and applied a broad range of N : P ratios (2.67-48). Silicic acid was supplied at 15 µmol L-1 in all mesocosms. We monitored nutrient drawdown, biomass accumulation and nitrogen fixation in response to variable nutrient stoichiometry. Our results confirmed nitrate to be the key factor determining primary production. We found that excess phosphate was channeled through particulate organic matter (POP) into the dissolved organic matter (DOP) pool. In mesocosms with low inorganic phosphate availability, DOP was utilized while N2 fixation increased, suggesting a link between those two processes. Interestingly this observation was most pronounced in mesocosms where nitrate was still available, indicating that bioavailable N does not necessarily suppress N2 fixation. We observed a shift from a mixed cyanobacteria-proteobacteria dominated active diazotrophic community towards a diatom-diazotrophic association of the Richelia-Rhizosolenia symbiosis. We hypothesize that a potential change in nutrient stoichiometry in the ETNA might lead to a general shift within

  5. Small Unmanned Aircraft Systems Integration into the National Airspace System Visual-Line-of-Sight Human-in-the-Loop Experiment

    NASA Technical Reports Server (NTRS)

    Trujillo, Anna C.; Ghatas, Rania W.; Mcadaragh, Raymon; Burdette, Daniel W.; Comstock, James R.; Hempley, Lucas E.; Fan, Hui

    2015-01-01

    As part of the Unmanned Aircraft Systems (UAS) in the National Airspace System (NAS) project, research on integrating small UAS (sUAS) into the NAS was underway by a human-systems integration (HSI) team at the NASA Langley Research Center. Minimal to no research has been conducted on the safe, effective, and efficient manner in which to integrate these aircraft into the NAS. sUAS are defined as aircraft weighing 55 pounds or less. The objective of this human system integration team was to build a UAS Ground Control Station (GCS) and to develop a research test-bed and database that provides data, proof of concept, and human factors guidelines for GCS operations in the NAS. The objectives of this experiment were to evaluate the effectiveness and safety of flying sUAS in Class D and Class G airspace utilizing manual control inputs and voice radio communications between the pilot, mission control, and air traffic control. The design of the experiment included three sets of GCS display configurations, in addition to a hand-held control unit. The three different display configurations were VLOS, VLOS + Primary Flight Display (PFD), and VLOS + PFD + Moving Map (Map). Test subject pilots had better situation awareness of their vehicle position, altitude, airspeed, location over the ground, and mission track using the Map display configuration. This configuration allowed the pilots to complete the mission objectives with less workload, at the expense of having better situation awareness of other aircraft. The subjects were better able to see other aircraft when using the VLOS display configuration. However, their mission performance, as well as their ability to aviate and navigate, was reduced compared to runs that included the PFD and Map displays.

  6. Gene repression by minimal lac loops in vivo.

    PubMed

    Bond, Laura M; Peters, Justin P; Becker, Nicole A; Kahn, Jason D; Maher, L James

    2010-12-01

    The inflexibility of double-stranded DNA with respect to bending and twisting is well established in vitro. Understanding apparent DNA physical properties in vivo is a greater challenge. Here, we exploit repression looping with components of the Escherichia coli lac operon to monitor DNA flexibility in living cells. We create a minimal system for testing the shortest possible DNA repression loops that contain an E. coli promoter, and compare the results to prior experiments. Our data reveal that loop-independent repression occurs for certain tight operator/promoter spacings. When only loop-dependent repression is considered, fits to a thermodynamic model show that DNA twisting limits looping in vivo, although the apparent DNA twist flexibility is 2- to 4-fold higher than in vitro. In contrast, length-dependent resistance to DNA bending is not observed in these experiments, even for the shortest loops constraining <0.4 persistence lengths of DNA. As observed previously for other looping configurations, loss of the nucleoid protein heat unstable (HU) markedly disables DNA looping in vivo. Length-independent DNA bending energy may reflect the activities of architectural proteins and the structure of the DNA topological domain. We suggest that the shortest loops are formed in apical loops rather than along the DNA plectonemic superhelix.

  7. Investigation of Low Power Operation in a Loop Heat Pipe

    NASA Technical Reports Server (NTRS)

    Ku, Jentung; Ottenstein, Laura; Rogers, Paul; Cheung, Kwok; Powers, Edward I. (Technical Monitor)

    2001-01-01

    This paper presents test results of an experimental study of low power operation in a loop heat pipe. The main objective was to demonstrate how changes in the vapor void fraction inside the evaporator core would affect the loop behavior, The fluid inventory and the relative tilt between the evaporator and the compensation chamber were varied so as to create different vapor void fractions in the evaporator core. The effect on the loop start-up, operating temperature, and capillary limit was investigated. Test results indicate that the vapor void fraction inside the evaporator core is the single most important factor in determining the loop operation at low powers.

  8. Modulation of DNA loop lifetimes by the free energy of loop formation

    PubMed Central

    Chen, Yi-Ju; Johnson, Stephanie; Mulligan, Peter; Spakowitz, Andrew J.; Phillips, Rob

    2014-01-01

    Storage and retrieval of the genetic information in cells is a dynamic process that requires the DNA to undergo dramatic structural rearrangements. DNA looping is a prominent example of such a structural rearrangement that is essential for transcriptional regulation in both prokaryotes and eukaryotes, and the speed of such regulations affects the fitness of individuals. Here, we examine the in vitro looping dynamics of the classic Lac repressor gene-regulatory motif. We show that both loop association and loop dissociation at the DNA-repressor junctions depend on the elastic deformation of the DNA and protein, and that both looping and unlooping rates approximately scale with the looping J factor, which reflects the system’s deformation free energy. We explain this observation by transition state theory and model the DNA–protein complex as an effective worm-like chain with twist. We introduce a finite protein–DNA binding interaction length, in competition with the characteristic DNA deformation length scale, as the physical origin of the previously unidentified loop dissociation dynamics observed here, and discuss the robustness of this behavior to perturbations in several polymer parameters. PMID:25411314

  9. Toward a Theory and Practice for Whole-Person Learning: Reconceptualizing Experience and the Role of Affect.

    ERIC Educational Resources Information Center

    Yorks, Lyle; Kasl, Elizabeth

    2002-01-01

    A pragmatic perspective favors reflective discourse over affect. Heron's theory of personhood takes a phenomenological approach to affective learning. Strategies from this approach can be applied to the phenomenon of learning-within-relationship, in which individuals engage their own whole-person learning and that of others. (Contains 36…

  10. Smart feedback loops

    NASA Astrophysics Data System (ADS)

    Chepurnov, A. S.; Gribov, I. V.; Gudkov, K. A.; Shumakov, A. V.; Shvedunov, V. I.

    1994-12-01

    It is necessary to find the golden mean in allocating the processing resources of a computer control system. Traditionally, feedback loops operate at the lower levels to ensure safe and stable operation of the accelerator. At present we use analogue and digital feedback loops. Some systems, such as the RF, require more complex algorithms. A possible way of providing these, using digital signal processors is described. The results of tests with the Race-Track Microtron Linac are given and the sources of the main internal and external disturbances have been analysed.

  11. Concentric Loop Surface Coil

    NASA Astrophysics Data System (ADS)

    Hernández-Flores, R.; Rodríguez-González, A. O.; Salgado-Lujambio, P.; Barrios-Alvarez, F. A.

    2002-08-01

    A surface coil for MRI consisted of two concentric loops was developed for brain imaging. Prior to build the coil prototype, the magnetic field (B1) generated by the coil was numerically simulated. This field simulation is based on the Biot-Savart law for the circular- and square-shaped loops. From these theoretical results, we can appreciate an improvement on the B1 homogeneity. Brain images obtained at 1.5 Tesla show a good sensitivity in a particular region of interest. Also, these images compared well against images obtained with a circular-shaped coil. This receiver coil can generate high quality brain images.

  12. Wilson-loop instantons

    NASA Technical Reports Server (NTRS)

    Lee, Kimyeong; Holman, Richard; Kolb, Edward W.

    1987-01-01

    Wilson-loop symmetry breaking is considered on a space-time of the form M4 x K, where M4 is a four-dimensional space-time and K is an internal space with nontrivial and finite fundamental group. It is shown in a simple model that the different vacua obtained by breaking a non-Abelian gauge group by Wilson loops are separated in the space of gauge potentials by a finite energy barrier. An interpolating gauge configuration is then constructed between these vacua and shown to have minimum energy. Finally some implications of this construction are discussed.

  13. Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes

    PubMed Central

    Sanborn, Adrian L.; Rao, Suhas S. P.; Huang, Su-Chen; Durand, Neva C.; Huntley, Miriam H.; Jewett, Andrew I.; Bochkov, Ivan D.; Chinnappan, Dharmaraj; Cutkosky, Ashok; Li, Jian; Geeting, Kristopher P.; Gnirke, Andreas; Melnikov, Alexandre; McKenna, Doug; Stamenova, Elena K.; Lander, Eric S.; Aiden, Erez Lieberman

    2015-01-01

    We recently used in situ Hi-C to create kilobase-resolution 3D maps of mammalian genomes. Here, we combine these maps with new Hi-C, microscopy, and genome-editing experiments to study the physical structure of chromatin fibers, domains, and loops. We find that the observed contact domains are inconsistent with the equilibrium state for an ordinary condensed polymer. Combining Hi-C data and novel mathematical theorems, we show that contact domains are also not consistent with a fractal globule. Instead, we use physical simulations to study two models of genome folding. In one, intermonomer attraction during polymer condensation leads to formation of an anisotropic “tension globule.” In the other, CCCTC-binding factor (CTCF) and cohesin act together to extrude unknotted loops during interphase. Both models are consistent with the observed contact domains and with the observation that contact domains tend to form inside loops. However, the extrusion model explains a far wider array of observations, such as why loops tend not to overlap and why the CTCF-binding motifs at pairs of loop anchors lie in the convergent orientation. Finally, we perform 13 genome-editing experiments examining the effect of altering CTCF-binding sites on chromatin folding. The convergent rule correctly predicts the affected loops in every case. Moreover, the extrusion model accurately predicts in silico the 3D maps resulting from each experiment using only the location of CTCF-binding sites in the WT. Thus, we show that it is possible to disrupt, restore, and move loops and domains using targeted mutations as small as a single base pair. PMID:26499245

  14. Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes.

    PubMed

    Sanborn, Adrian L; Rao, Suhas S P; Huang, Su-Chen; Durand, Neva C; Huntley, Miriam H; Jewett, Andrew I; Bochkov, Ivan D; Chinnappan, Dharmaraj; Cutkosky, Ashok; Li, Jian; Geeting, Kristopher P; Gnirke, Andreas; Melnikov, Alexandre; McKenna, Doug; Stamenova, Elena K; Lander, Eric S; Aiden, Erez Lieberman

    2015-11-24

    We recently used in situ Hi-C to create kilobase-resolution 3D maps of mammalian genomes. Here, we combine these maps with new Hi-C, microscopy, and genome-editing experiments to study the physical structure of chromatin fibers, domains, and loops. We find that the observed contact domains are inconsistent with the equilibrium state for an ordinary condensed polymer. Combining Hi-C data and novel mathematical theorems, we show that contact domains are also not consistent with a fractal globule. Instead, we use physical simulations to study two models of genome folding. In one, intermonomer attraction during polymer condensation leads to formation of an anisotropic "tension globule." In the other, CCCTC-binding factor (CTCF) and cohesin act together to extrude unknotted loops during interphase. Both models are consistent with the observed contact domains and with the observation that contact domains tend to form inside loops. However, the extrusion model explains a far wider array of observations, such as why loops tend not to overlap and why the CTCF-binding motifs at pairs of loop anchors lie in the convergent orientation. Finally, we perform 13 genome-editing experiments examining the effect of altering CTCF-binding sites on chromatin folding. The convergent rule correctly predicts the affected loops in every case. Moreover, the extrusion model accurately predicts in silico the 3D maps resulting from each experiment using only the location of CTCF-binding sites in the WT. Thus, we show that it is possible to disrupt, restore, and move loops and domains using targeted mutations as small as a single base pair.

  15. The Energy Landscape of Hyperstable LacI-DNA Loops

    NASA Astrophysics Data System (ADS)

    Kahn, Jason

    2009-03-01

    The Escherichia coli LacI protein represses transcription of the lac operon by blocking access to the promoter through binding at a promoter-proximal DNA operator. The affinity of tetrameric LacI (and therefore the repression efficiency) is enhanced by simultaneous binding to an auxiliary operator, forming a DNA loop. Hyperstable LacI-DNA loops were previously shown to be formed on DNA constructs that include a sequence-directed bend flanked by operators. Biochemical experiments showed that two such constructs (9C14 and 11C12) with different helical phasing between the operators and the DNA bend form different DNA loop shapes. The geometry and topology of the loops and the relevance of alternative conformations suggested by probable flexible linkers in LacI remain unclear. Bulk and single molecule fluorescence resonance energy transfer (SM-FRET, with D. English) experiments on a dual fluorophore-labeled 9C14-LacI loop demonstrate that it adopts a single, stable, rigid closed-form loop conformation. Here, we characterize the LacI-9C14 loop by SM-FRET as a function of inducer isopropyl-β,D-thiogalactoside (IPTG) concentration. Energy transfer measurements reveal partial but incomplete destabilization of loop formation by IPTG. Surprisingly, there is no change in the energy transfer efficiency of the remaining looped population. Models for the regulation of the lac operon often assume complete disruption of LacI-operator complexes upon inducer binding to LacI. Our work shows that even at saturating IPTG there is still a significant population of LacI-DNA complexes in a looped state, in accord with previous in vivo experiments that show incomplete induction (with J. Maher). Finally, we will report progress on characterizing the ``energy landscape'' for DNA looping upon systematic variation of the DNA linkers between the operators and the bending locus. Rod mechanics simulations (with N. Perkins) provide testable predictions on loop stability, topology, and FRET.

  16. Livermore Compiler Analysis Loop Suite

    SciTech Connect

    Hornung, R. D.

    2013-03-01

    LCALS is designed to evaluate compiler optimizations and performance of a variety of loop kernels and loop traversal software constructs. Some of the loop kernels are pulled directly from "Livermore Loops Coded in C", developed at LLNL (see item 11 below for details of earlier code versions). The older suites were used to evaluate floating-point performances of hardware platforms prior to porting larger application codes. The LCALS suite is geared toward assissing C++ compiler optimizations and platform performance related to SIMD vectorization, OpenMP threading, and advanced C++ language features. LCALS contains 20 of 24 loop kernels from the older Livermore Loop suites, plus various others representative of loops found in current production appkication codes at LLNL. The latter loops emphasize more diverse loop constructs and data access patterns than the others, such as multi-dimensional difference stencils. The loops are included in a configurable framework, which allows control of compilation, loop sampling for execution timing, which loops are run and their lengths. It generates timing statistics for analysis and comparing variants of individual loops. Also, it is easy to add loops to the suite as desired.

  17. Multiday Fully Closed Loop Insulin Delivery in Monitored Outpatient Conditions

    ClinicalTrials.gov

    2014-04-29

    To Demonstrate That the Closed Loop System Can be Used Safely Over a Few Consecutive Days.; To Assess Effectiveness in Maintaining Patients' Glucose Levels in the Target Range of 70 to 180 mg/dl, Measured by Blood Glucose Sensor.; To Evaluate the User Experience With a Closed Loop System

  18. "You're Facing That Machine but There's a Human Being behind It": Students' Affective Experiences on an Online Doctoral Programme

    ERIC Educational Resources Information Center

    Kennedy, Eileen; Gray, Morag

    2016-01-01

    Online students use highly emotional language to describe their experiences, indicating that learners do feel a great deal online. This paper draws on Wetherell's exploration of affective practice to theorise learners' responses to the pedagogical and technological online environment. Findings of a research project that focused on two cohorts of…

  19. Counting primary loops in polymer gels

    PubMed Central

    Zhou, Huaxing; Woo, Jiyeon; Cok, Alexandra M.; Wang, Muzhou; Olsen, Bradley D.; Johnson, Jeremiah A.

    2012-01-01

    Much of our fundamental knowledge related to polymer networks is built on an assumption of ideal end-linked network structure. Real networks invariably possess topological imperfections that negatively affect mechanical properties; modifications of classical network theories have been developed to account for these defects. Despite decades of effort, there are no known experimental protocols for precise quantification of even the simplest topological network imperfections: primary loops. Here we present a simple conceptual framework that enables primary loop quantification in polymeric materials. We apply this framework to measure the fraction of primary loop junctions in trifunctional PEG-based hydrogels. We anticipate that the concepts described here will open new avenues of theoretical and experimental research related to polymer network structure. PMID:23132947

  20. DC servomechanism parameter identification: a Closed Loop Input Error approach.

    PubMed

    Garrido, Ruben; Miranda, Roger

    2012-01-01

    This paper presents a Closed Loop Input Error (CLIE) approach for on-line parametric estimation of a continuous-time model of a DC servomechanism functioning in closed loop. A standard Proportional Derivative (PD) position controller stabilizes the loop without requiring knowledge on the servomechanism parameters. The analysis of the identification algorithm takes into account the control law employed for closing the loop. The model contains four parameters that depend on the servo inertia, viscous, and Coulomb friction as well as on a constant disturbance. Lyapunov stability theory permits assessing boundedness of the signals associated to the identification algorithm. Experiments on a laboratory prototype allows evaluating the performance of the approach.

  1. NETL - Chemical Looping Reactor

    SciTech Connect

    2013-07-24

    NETL's Chemical Looping Reactor unit is a high-temperature integrated CLC process with extensive instrumentation to improve computational simulations. A non-reacting test unit is also used to study solids flow at ambient temperature. The CLR unit circulates approximately 1,000 pounds per hour at temperatures around 1,800 degrees Fahrenheit.

  2. Closing the Loop Sampler.

    ERIC Educational Resources Information Center

    California Integrated Waste Management Board, Sacramento.

    Closing the Loop (CTL) is a science curriculum designed to introduce students to integrated waste management through awareness. This document presents five lesson plans focusing on developing an understanding of natural resources, solid wastes, conservation, and the life of landfills. Contents include: (1) "What Are Natural Resources?"; (2)…

  3. NETL - Chemical Looping Reactor

    ScienceCinema

    None

    2016-07-12

    NETL's Chemical Looping Reactor unit is a high-temperature integrated CLC process with extensive instrumentation to improve computational simulations. A non-reacting test unit is also used to study solids flow at ambient temperature. The CLR unit circulates approximately 1,000 pounds per hour at temperatures around 1,800 degrees Fahrenheit.

  4. A monolithic 3D-0D coupled closed-loop model of the heart and the vascular system: Experiment-based parameter estimation for patient-specific cardiac mechanics.

    PubMed

    Hirschvogel, Marc; Bassilious, Marina; Jagschies, Lasse; Wildhirt, Stephen M; Gee, Michael W

    2016-10-15

    A model for patient-specific cardiac mechanics simulation is introduced, incorporating a 3-dimensional finite element model of the ventricular part of the heart, which is coupled to a reduced-order 0-dimensional closed-loop vascular system, heart valve, and atrial chamber model. The ventricles are modeled by a nonlinear orthotropic passive material law. The electrical activation is mimicked by a prescribed parameterized active stress acting along a generic muscle fiber orientation. Our activation function is constructed such that the start of ventricular contraction and relaxation as well as the active stress curve's slope are parameterized. The imaging-based patient-specific ventricular model is prestressed to low end-diastolic pressure to account for the imaged, stressed configuration. Visco-elastic Robin boundary conditions are applied to the heart base and the epicardium to account for the embedding surrounding. We treat the 3D solid-0D fluid interaction as a strongly coupled monolithic problem, which is consistently linearized with respect to 3D solid and 0D fluid model variables to allow for a Newton-type solution procedure. The resulting coupled linear system of equations is solved iteratively in every Newton step using 2  ×  2 physics-based block preconditioning. Furthermore, we present novel efficient strategies for calibrating active contractile and vascular resistance parameters to experimental left ventricular pressure and stroke volume data gained in porcine experiments. Two exemplary states of cardiovascular condition are considered, namely, after application of vasodilatory beta blockers (BETA) and after injection of vasoconstrictive phenylephrine (PHEN). The parameter calibration to the specific individual and cardiovascular state at hand is performed using a 2-stage nonlinear multilevel method that uses a low-fidelity heart model to compute a parameter correction for the high-fidelity model optimization problem. We discuss 2 different low

  5. Early and Later Experience with One Younger Sibling Affects Face Processing Abilities of 6-Year-Old Children

    ERIC Educational Resources Information Center

    Cassia, Viola Macchi; Proietti, Valentina; Pisacane, Antonella

    2013-01-01

    Available evidence indicates that experience with one face from a specific age group improves face-processing abilities if acquired within the first 3 years of life but not in adulthood. In the current study, we tested whether the effects of early experience endure at age 6 and whether the first 3 years of life are a sensitive period for the…

  6. Do Proficiency and Study-Abroad Experience Affect Speech Act Production? Analysis of Appropriateness, Accuracy, and Fluency

    ERIC Educational Resources Information Center

    Taguchi, Naoko

    2011-01-01

    This cross-sectional study examined the effect of general proficiency and study-abroad experience in production of speech acts among learners of L2 English. Participants were 25 native speakers of English and 64 Japanese college students of English divided into three groups. Group 1 (n = 22) had lower proficiency and no study-abroad experience.…

  7. Does the Lack of Hands-On Experience in a Remotely Delivered Laboratory Course Affect Student Learning?

    ERIC Educational Resources Information Center

    Abdel-Salam, Tarek; Kauffman, Paul J.; Crossman, Gary

    2006-01-01

    Educators question whether performing a laboratory experiment as an observer (non-hands-on), such as conducted in a distance education context, can be as effective a learning tool as personally performing the experiment in a laboratory environment. The present paper investigates this issue by comparing the performance of distance education…

  8. Iterative LQG Controller Design Through Closed-Loop Identification

    NASA Technical Reports Server (NTRS)

    Hsiao, Min-Hung; Huang, Jen-Kuang; Cox, David E.

    1996-01-01

    This paper presents an iterative Linear Quadratic Gaussian (LQG) controller design approach for a linear stochastic system with an uncertain open-loop model and unknown noise statistics. This approach consists of closed-loop identification and controller redesign cycles. In each cycle, the closed-loop identification method is used to identify an open-loop model and a steady-state Kalman filter gain from closed-loop input/output test data obtained by using a feedback LQG controller designed from the previous cycle. Then the identified open-loop model is used to redesign the state feedback. The state feedback and the identified Kalman filter gain are used to form an updated LQC controller for the next cycle. This iterative process continues until the updated controller converges. The proposed controller design is demonstrated by numerical simulations and experiments on a highly unstable large-gap magnetic suspension system.

  9. COLD TEST LOOP INTEGRATED TEST LOOP RESULTS

    SciTech Connect

    Abraham, TJ

    2003-10-22

    A testing facility (Cold Test Loop) was constructed and operated to demonstrate the efficacy of the Accelerated Waste Retrieval (AWR) Project's planned sluicing approach to the remediation of Silos 1 and 2 at the Fernald Environmental Management Project near Cincinnati, Ohio. The two silos contain almost 10,000 tons of radium-bearing low-level waste, which consists primarily of solids of raffinates from processing performed on ores from the Democratic Republic of Congo (commonly referred to as ''Belgium Congo ores'') for the recovery of uranium. These silos are 80 ft in diameter, 36 ft high to the center of the dome, and 26.75 ft to the top of the vertical side walls. The test facility contained two test systems, each designed for a specific purpose. The first system, the Integrated Test Loop (ITL), a near-full-scale plant including the actual equipment to be installed at the Fernald Site, was designed to demonstrate the sluicing operation and confirm the selection of a slurry pump, the optimal sluicing nozzle operation, and the preliminary design material balance. The second system, the Component Test Loop (CTL), was designed to evaluate many of the key individual components of the waste retrieval system over an extended run. The major results of the initial testing performed during July and August 2002 confirmed that the AWR approach to sluicing was feasible. The ITL testing confirmed the following: (1) The selected slurry pump (Hazleton 3-20 type SHW) performed well and is suitable for AWR application. However, the pump's motor should be upgraded to a 200-hp model and be driven by a 150-hp variable-frequency drive (VFD). A 200-hp VFD is not much more expensive and would allow the pump to operate at full speed. (2) The best nozzle performance was achieved by using 15/16-in. nozzles operated alternately. This configuration appeared to most effectively mine the surrogate. (3) The Solartron densitometer, which was tested as an alternative mass flow measurement

  10. High-performers use the phonological loop less to process mental arithmetic during working memory tasks.

    PubMed

    Otsuka, Yuki; Osaka, Naoyuki

    2015-01-01

    This study investigated the effects of three working memory components-the central executive, phonological loop, and visuospatial sketchpad-on performance differences in complex mental arithmetic between individuals. Using the dual-task method, we examined how performance during two-digit addition was affected by load on the central executive (random tapping condition), phonological loop (articulatory suppression condition), and visuospatial sketchpad (spatial tapping condition) compared to that under no load (control condition) in high- and low-performers of complex mental arithmetic in Experiment 1. Low-performers showed an increase in errors under the random tapping and articulatory suppression conditions, whereas high-performers showed an increase of errors only under the random tapping condition. In Experiment 2, we conducted similar experiments on only the high-performers but used a shorter presentation time of each number. We found the same pattern for performing complex mental arithmetic as seen in Experiment 1. These results indicate that high-performers might reduce their dependence on the phonological loop, because the central executive enables them to choose a strategy in which they use less working memory capacity.

  11. How Mg(2+) ion and water network affect the stability and structure of non-Watson-Crick base pairs in E. coli loop E of 5S rRNA: a molecular dynamics and reference interaction site model (RISM) study.

    PubMed

    Shanker, Sudhanshu; Bandyopadhyay, Pradipta

    2016-08-02

    The non-Watson-Crick (non-WC) base pairs of Escherichia coli loop E of 5S rRNA are stabilized by Mg(2+) ions through water-mediated interaction. It is important to know the synergic role of Mg(2+) and the water network surrounding Mg(2+) in stabilizing the non-WC base pairs of RNA. For this purpose, free energy change of the system is calculated using molecular dynamics (MD) simulation as Mg(2+) is pulled from RNA, which causes disturbance of the water network. It was found that Mg(2+) remains hexahydrated unless it is close to or far from RNA. In the pentahydrated form, Mg(2+) interacts directly with RNA. Water network has been identified by two complimentary methods; MD followed by a density-based clustering algorithm and three-dimensional-reference interaction site model. These two methods gave similar results. Identification of water network around Mg(2+) and non-WC base pairs gives a clue to the strong effect of water network on the stability of this RNA. Based on sequence analysis of all Eubacteria 5s rRNA, we propose that hexahydrated Mg(2+) is an integral part of this RNA and geometry of base pairs surrounding it adjust to accommodate the [Formula: see text]. Overall the findings from this work can help in understanding the basis of the complex structure and stability of RNA with non-WC base pairs.

  12. Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses.

    PubMed

    Rudinskiy, Nikita; Hawkes, Jonathan M; Wegmann, Susanne; Kuchibhotla, Kishore V; Muzikansky, Alona; Betensky, Rebecca A; Spires-Jones, Tara L; Hyman, Bradley T

    2014-06-10

    Intraneuronal neurofibrillary tangles (NFTs) - a characteristic pathological feature of Alzheimer's and several other neurodegenerative diseases - are considered a major target for drug development. Tangle load correlates well with the severity of cognitive symptoms and mouse models of tauopathy are behaviorally impaired. However, there is little evidence that NFTs directly impact physiological properties of host neurons. Here we used a transgenic mouse model of tauopathy to study how advanced tau pathology in different brain regions affects activity-driven expression of immediate-early gene Arc required for experience-dependent consolidation of long-term memories. We demonstrate in vivo that visual cortex neurons with tangles are as likely to express comparable amounts of Arc in response to structured visual stimulation as their neighbors without tangles. Probability of experience-dependent Arc response was not affected by tau tangles in both visual cortex and hippocampal pyramidal neurons as determined postmortem. Moreover, whole brain analysis showed that network-wide activity-driven Arc expression was not affected by tau pathology in any of the brain regions, including brain areas with the highest tangle load. Our findings suggest that intraneuronal NFTs do not affect signaling cascades leading to experience-dependent gene expression required for long-term synaptic plasticity.

  13. Parameterizing loop fusion for automated empirical tuning

    SciTech Connect

    Zhao, Y; Yi, Q; Kennedy, K; Quinlan, D; Vuduc, R

    2005-12-15

    Traditional compilers are limited in their ability to optimize applications for different architectures because statically modeling the effect of specific optimizations on different hardware implementations is difficult. Recent research has been addressing this issue through the use of empirical tuning, which uses trial executions to determine the optimization parameters that are most effective on a particular hardware platform. In this paper, we investigate empirical tuning of loop fusion, an important transformation for optimizing a significant class of real-world applications. In spite of its usefulness, fusion has attracted little attention from previous empirical tuning research, partially because it is much harder to configure than transformations like loop blocking and unrolling. This paper presents novel compiler techniques that extend conventional fusion algorithms to parameterize their output when optimizing a computation, thus allowing the compiler to formulate the entire configuration space for loop fusion using a sequence of integer parameters. The compiler can then employ an external empirical search engine to find the optimal operating point within the space of legal fusion configurations and generate the final optimized code using a simple code transformation system. We have implemented our approach within our compiler infrastructure and conducted preliminary experiments using a simple empirical search strategy. Our results convey new insights on the interaction of loop fusion with limited hardware resources, such as available registers, while confirming conventional wisdom about the effectiveness of loop fusion in improving application performance.

  14. Assessment of Habitat Suitability Is Affected by Plant-Soil Feedback: Comparison of Field and Garden Experiment

    PubMed Central

    Hemrová, Lucie; Knappová, Jana; Münzbergová, Zuzana

    2016-01-01

    Background Field translocation experiments (i.e., the introduction of seeds or seedlings of different species into different localities) are commonly used to study habitat associations of species, as well as factors limiting species distributions and local abundances. Species planted or sown in sites where they naturally occur are expected to perform better or equally well compared to sites at which they do not occur or are rare. This, however, contrasts with the predictions of the Janzen-Connell hypothesis and commonly reported intraspecific negative plant-soil feedback. The few previous studies indicating poorer performance of plants at sites where they naturally occur did not explore the mechanisms behind this pattern. Aims and Methods In this study, we used field translocation experiments established using both seeds and seedlings to study the determinants of local abundance of four dominant species in grasslands. To explore the possible effects of intraspecific negative plant-soil feedback on our results, we tested the effect of local species abundance on the performance of the plants in the field experiment. In addition, we set up a garden experiment to explore the intensity of intraspecific as well as interspecific feedback between the dominants used in the experiment. Key Results In some cases, the distribution and local abundances of the species were partly driven by habitat conditions at the sites, and species performed better at their own sites. However, the prevailing pattern was that the local dominants performed worse at sites where they naturally occur than at any other sites. Moreover, the success of plants in the field experiment was lower in the case of higher intraspecific abundance prior to experimental setup. In the garden feedback experiment, two of the species performed significantly worse in soils conditioned by their species than in soils conditioned by the other species. In addition, the performance of the plants was significantly

  15. How Workplace Experiences While at School Affect Career Pathways. A National Vocational Education and Training Research and Evaluation Program Report

    ERIC Educational Resources Information Center

    Smith, Erica; Green, Annette

    2005-01-01

    This report describes and analyses how the work activities undertaken by students while at school affect their post-school pathways into and between work and study. Increasingly, students are involved with workplaces while still at school. The three major ways in which this is happening (in order of extent of engagement) are through work…

  16. Does the Grammatical Count/Mass Distinction Affect Semantic Representations? Evidence from Experiments in English and Japanese

    ERIC Educational Resources Information Center

    Iwasaki, Noriko; Vinson, David P.; Vigliocco, Gabriella

    2010-01-01

    We investigate linguistic relativity effects by examining whether the grammatical count/mass distinction in English affects English speakers' semantic representations of noun referents, as compared with those of Japanese speakers, whose language does not grammatically distinguish nouns for countability. We used two tasks which are sensitive to…

  17. Loop Heat Pipes and Capillary Pumped Loops: An Applications Perspective

    NASA Technical Reports Server (NTRS)

    Butler, Dan; Ku, Jentung; Swanson, Theodore; Obenschain, Arthur F. (Technical Monitor)

    2001-01-01

    Capillary pumped loops (CPLS) and loop heat pipes (LHPS) are versatile two-phase heat transfer devices which have recently gained increasing acceptance in space applications. Both systems work based on the same principles and have very similar designs. Nevertheless, some differences exist in the construction of the evaporator and the hydro-accumulator, and these differences lead to very distinct operating characteristics for each loop. This paper presents comparisons of the two loops from an applications perspective, and addresses their impact on spacecraft design, integration, and test. Some technical challenges and issues for both loops are also addressed.

  18. Genetic and environmental causes of individual differences in daily life positive affect and reward experience and its overlap with stress-sensitivity.

    PubMed

    Menne-Lothmann, Claudia; Jacobs, Nele; Derom, Catherine; Thiery, Evert; van Os, Jim; Wichers, Marieke

    2012-09-01

    Momentary positive affect (PA) and reward experience may underlie subjective wellbeing, and index mental health resilience. This study examines their underlying sources of variation and the covariation with stress-sensitivity. The experience sampling method was used to collect multiple appraisals of mood and daily life events in 520 female twins. Structural equation model fitting was employed to determine sources of variation of PA, reward experience, and the association between reward experience and stress-sensitivity. PA was best explained by shared and non-shared environmental factors, and reward experience by non-shared environmental factors only, although the evidence was also suggestive of a small genetic contribution. Reward experience and stress-sensitivity showed no association. PA was not heritable. Most-if not all-variance of reward experience was explained by environmental influences. Stress-sensitivity, indexing depression vulnerability, and reward experience were non-overlapping, suggesting that resilience traits are independent from stress-sensitivity levels in a general population sample.

  19. Aurora Australis, Sinuous Loop

    NASA Technical Reports Server (NTRS)

    1991-01-01

    This view of the Aurora Australis or Southern Lights (location unknown) shows a sinuous looping band of airglow above the Earth Limb. Calculated to be in the 80 - 120 km altitude region, auroral activity is due to exitation of atomic oxygen in the upper atmosphere by radiation from the van Allen Radiation Belts and is most common above the 65 degree north and south latitude range during the spring and fall of the year.

  20. Loop Quantum Cosmology.

    PubMed

    Bojowald, Martin

    2005-01-01

    Quantum gravity is expected to be necessary in order to understand situations where classical general relativity breaks down. In particular in cosmology one has to deal with initial singularities, i.e., the fact that the backward evolution of a classical space-time inevitably comes to an end after a finite amount of proper time. This presents a breakdown of the classical picture and requires an extended theory for a meaningful description. Since small length scales and high curvatures are involved, quantum effects must play a role. Not only the singularity itself but also the surrounding space-time is then modified. One particular realization is loop quantum cosmology, an application of loop quantum gravity to homogeneous systems, which removes classical singularities. Its implications can be studied at different levels. Main effects are introduced into effective classical equations which allow to avoid interpretational problems of quantum theory. They give rise to new kinds of early universe phenomenology with applications to inflation and cyclic models. To resolve classical singularities and to understand the structure of geometry around them, the quantum description is necessary. Classical evolution is then replaced by a difference equation for a wave function which allows to extend space-time beyond classical singularities. One main question is how these homogeneous scenarios are related to full loop quantum gravity, which can be dealt with at the level of distributional symmetric states. Finally, the new structure of space-time arising in loop quantum gravity and its application to cosmology sheds new light on more general issues such as time.

  1. Loop Quantum Cosmology.

    PubMed

    Bojowald, Martin

    2008-01-01

    Quantum gravity is expected to be necessary in order to understand situations in which classical general relativity breaks down. In particular in cosmology one has to deal with initial singularities, i.e., the fact that the backward evolution of a classical spacetime inevitably comes to an end after a finite amount of proper time. This presents a breakdown of the classical picture and requires an extended theory for a meaningful description. Since small length scales and high curvatures are involved, quantum effects must play a role. Not only the singularity itself but also the surrounding spacetime is then modified. One particular theory is loop quantum cosmology, an application of loop quantum gravity to homogeneous systems, which removes classical singularities. Its implications can be studied at different levels. The main effects are introduced into effective classical equations, which allow one to avoid the interpretational problems of quantum theory. They give rise to new kinds of early-universe phenomenology with applications to inflation and cyclic models. To resolve classical singularities and to understand the structure of geometry around them, the quantum description is necessary. Classical evolution is then replaced by a difference equation for a wave function, which allows an extension of quantum spacetime beyond classical singularities. One main question is how these homogeneous scenarios are related to full loop quantum gravity, which can be dealt with at the level of distributional symmetric states. Finally, the new structure of spacetime arising in loop quantum gravity and its application to cosmology sheds light on more general issues, such as the nature of time.

  2. Loops of Jupiter

    NASA Astrophysics Data System (ADS)

    Opolski, Antoni

    2014-12-01

    Professor Antoni Opolski was actively interested in astronomy after his retirement in 1983. He especially liked to study the works of the famous astronomer Copernicus getting inspiration for his own work. Opolski started his work on planetary loops in 2011 continuing it to the end of 2012 . During this period calculations, drawings, tables, and basic descriptions of all the planets of the Solar System were created with the use of a piece of paper and a pencil only. In 2011 Antoni Opolski asked us to help him in editing the manuscript and preparing it for publication. We have been honored having the opportunity to work on articles on planetary loops with Antoni Opolski in his house for several months. In the middle of 2012 the detailed material on Jupiter was ready. However, professor Opolski improved the article by smoothing the text and preparing new, better drawings. Finally the article ''Loops of Jupiter'', written by the 99- year old astronomer, was published in the year of his 100th birthday.

  3. Verification of Loop Diagnostics

    NASA Technical Reports Server (NTRS)

    Winebarger, A.; Lionello, R.; Mok, Y.; Linker, J.; Mikic, Z.

    2014-01-01

    Many different techniques have been used to characterize the plasma in the solar corona: density-sensitive spectral line ratios are used to infer the density, the evolution of coronal structures in different passbands is used to infer the temperature evolution, and the simultaneous intensities measured in multiple passbands are used to determine the emission measure. All these analysis techniques assume that the intensity of the structures can be isolated through background subtraction. In this paper, we use simulated observations from a 3D hydrodynamic simulation of a coronal active region to verify these diagnostics. The density and temperature from the simulation are used to generate images in several passbands and spectral lines. We identify loop structures in the simulated images and calculate the loop background. We then determine the density, temperature and emission measure distribution as a function of time from the observations and compare with the true temperature and density of the loop. We find that the overall characteristics of the temperature, density, and emission measure are recovered by the analysis methods, but the details of the true temperature and density are not. For instance, the emission measure curves calculated from the simulated observations are much broader than the true emission measure distribution, though the average temperature evolution is similar. These differences are due, in part, to inadequate background subtraction, but also indicate a limitation of the analysis methods.

  4. Chemical Looping Combustion Kinetics

    SciTech Connect

    Edward Eyring; Gabor Konya

    2009-03-31

    One of the most promising methods of capturing CO{sub 2} emitted by coal-fired power plants for subsequent sequestration is chemical looping combustion (CLC). A powdered metal oxide such as NiO transfers oxygen directly to a fuel in a fuel reactor at high temperatures with no air present. Heat, water, and CO{sub 2} are released, and after H{sub 2}O condensation the CO{sub 2} (undiluted by N{sub 2}) is ready for sequestration, whereas the nickel metal is ready for reoxidation in the air reactor. In principle, these processes can be repeated endlessly with the original nickel metal/nickel oxide participating in a loop that admits fuel and rejects ash, heat, and water. Our project accumulated kinetic rate data at high temperatures and elevated pressures for the metal oxide reduction step and for the metal reoxidation step. These data will be used in computational modeling of CLC on the laboratory scale and presumably later on the plant scale. The oxygen carrier on which the research at Utah is focused is CuO/Cu{sub 2}O rather than nickel oxide because the copper system lends itself to use with solid fuels in an alternative to CLC called 'chemical looping with oxygen uncoupling' (CLOU).

  5. Using Wenger's Social Theory of Learning to Examine University Teachers' Understanding of How Instructional Technology Affects Their Experience in Practice

    ERIC Educational Resources Information Center

    Adams, Laura L.

    2010-01-01

    The purpose of this study was to take an exploratory look at how university teachers come to understand their experience in educational practice and their professional role as teachers who integrate instructional technology into their coursework using the framework provided by Wenger's Social Theory of Learning. University faculty who teach in a…

  6. Teachers' and Caregivers' Perceptions of Gender Differences in Educational Experiences of Children Affected by Parental AIDS in Western Kenya

    ERIC Educational Resources Information Center

    Jepkemboi, Grace; Aldridge, Jerry

    2009-01-01

    The purpose of this qualitative case study was to describe the perceptions of teachers and caregivers concerning gender differences in the educational experiences of children influenced by the HIV status of their parents or orphaned by AIDS in 7 orphanage schools of Western Kenya. 12 teachers and 8 caregivers participated in the study. Data were…

  7. A Model of Research Group Microclimate: Environmental and Cultural Factors Affecting the Experiences of Overseas Research Students in the UK

    ERIC Educational Resources Information Center

    Walsh, Elaine

    2010-01-01

    Researchers from outside the European Union represent an increasing proportion of the UK doctoral student body. However, relatively little research exists on their experience from their own perspective. This research, based on interviews with students from a range of countries and scientific and engineering disciplines, seeks to address that…

  8. Gaining a "Sense of Place": Students' Affective Experiences of Place Leading to Transformative Learning on International Fieldwork

    ERIC Educational Resources Information Center

    Simm, David; Marvell, Alan

    2015-01-01

    This paper reveals the extent to which undergraduate students demonstrate transformative learning whilst on international fieldwork in Barcelona, Spain. Groups of students create a series of discrete active learning situations that allow them and their peers to engage more fully with their locale and in turn experience a deeper understanding of…

  9. Transforming Misconceptions: Using Transformative Experience to Promote Positive Affect and Conceptual Change in Students Learning about Biological Evolution

    ERIC Educational Resources Information Center

    Heddy, Benjamin C.; Sinatra, Gale M.

    2013-01-01

    Teaching and learning about complex scientific content, such as biological evolution, is challenging in part because students have a difficult time seeing the relevance of evolution in their everyday lives. The purpose of this study was to explore the effectiveness of the Teaching for Transformative Experiences in Science (TTES) model (Pugh, 2002)…

  10. Assessing Dispositions in Pre-Service Teachers: Does Setting or Experience Affect Dispositions? A Mixed-Methods Study

    ERIC Educational Resources Information Center

    Frederiksen, Heidi

    2010-01-01

    The purpose of this study was to determine whether there was a significant difference between the perceived dispositions in pre-service teachers in urban settings versus non-urban settings. It was also the intent of this study to describe the change in perceived dispositions throughout pre-service teachers' internship experiences. Graduate…

  11. Does CenteringPregnancy Group Prenatal Care Affect the Birth Experience of Underserved Women? A Mixed Methods Analysis.

    PubMed

    Liu, Rhianon; Chao, Maria T; Jostad-Laswell, Ariana; Duncan, Larissa G

    2017-04-01

    We examined the birth experience of immigrant and minority women and how CenteringPregnancy (Centering), a model of group prenatal care and childbirth education, influenced that experience. In-depth interviews and surveys were conducted with a sample of racially diverse Centering participants about their birth experiences. Interview transcripts were analyzed thematically. Study participants (n = 34) were primarily low-income, Spanish-speaking immigrants with an average age of 29.7. On a scale from 1 (not satisfied) to 10 (very satisfied), women reported high satisfaction with birth (9.0) and care (9.3). In interviews, they expressed appreciation for the choice to labor with minimal medical intervention. Difficulties with communication arose from fragmented labor and delivery care by multiple providers. Centering provided women with pain coping skills, a familiar birth attendant, and knowledge to advocate for themselves. High reported satisfaction may obscure challenges to providing high quality childbirth care for marginalized women. Further study should examine the potential of Centering to positively impact underserved women's birth experiences.

  12. Sandia Sodium Purification Loop (SNAPL) description and operations manual

    SciTech Connect

    Acton, R.U.; Weatherbee, R.L.; Smith, L.A.; Mastin, F.L.; Nowotny, K.E.

    1985-08-01

    Sandia's Sodium Purification Loop was constructed to purify sodium for fast reactor safety experiments. An oxide impurity of less than 10 parts per million is required by these in-pile experiments. Commercial, reactor grade sodium is purchased in 180 kg drums. The sodium is melted and transferred into the unit. The unit is of a loop design and purification is accomplished by ''cold trapping.'' Sodium purified in this loop has been chemically analysed at one part per million oxygen by weight. 5 refs., 22 figs., 7 tabs.

  13. Examining the relationship between immediate serial recall and immediate free recall: common effects of phonological loop variables but only limited evidence for the phonological loop.

    PubMed

    Spurgeon, Jessica; Ward, Geoff; Matthews, William J

    2014-07-01

    We examined the contribution of the phonological loop to immediate free recall (IFR) and immediate serial recall (ISR) of lists of between one and 15 words. Following Baddeley (1986, 2000, 2007, 2012), we assumed that visual words could be recoded into the phonological store when presented silently but that recoding would be prevented by concurrent articulation (CA; Experiment 1). We further assumed that the use of the phonological loop would be evidenced by greater serial recall for lists of phonologically dissimilar words relative to lists of phonologically similar words (Experiments 2A and 2B). We found that in both tasks, (a) CA reduced recall; (b) participants recalled short lists from the start of the list, leading to enhanced forward-ordered recall; (c) participants were increasingly likely to recall longer lists from the end of the list, leading to extended recency effects; (d) there were significant phonological similarity effects in ISR and IFR when both were analyzed using serial recall scoring; (e) these were reduced by free recall scoring and eliminated by CA; and (f) CA but not phonological similarity affected the tendency to initiate recall with the first list item. We conclude that similar mechanisms underpin ISR and IFR. Critically, the phonological loop is not strictly necessary for the forward-ordered recall of short lists on both tasks but may augment recall by increasing the accessibility of the list items (relative to CA), and in so doing, the order of later items is preserved better in phonologically dissimilar than in phonologically similar lists.

  14. Is a closing "GA pair" a rule for stable loop-loop RNA complexes?

    PubMed

    Ducongé, F; Di Primo, C; Toulme, J J

    2000-07-14

    RNA hairpin aptamers specific for the trans-activation-responsive (TAR) RNA element of human immunodeficiency virus type 1 were identified by in vitro selection (Ducongé, F., and Toulmé, J. J. (1999) RNA 5, 1605-1614). The high affinity sequences selected at physiological magnesium concentration (3 mm) were shown to form a loop-loop complex with the targeted TAR RNA. The stability of this complex depends on the aptamer loop closing "GA pair" as characterized by preliminary electrophoretic mobility shift assays. Thermal denaturation monitored by UV-absorption spectroscopy and binding kinetics determined by surface plasmon resonance show that the GA pair is crucial for the formation of the TAR-RNA aptamer complex. Both thermal denaturation and surface plasmon resonance experiments show that any other "pairs" leads to complexes whose stability decreases in the order AG > GG > GU > AA > GC > UA > CA, CU. The binding kinetics indicate that stability is controlled by the off-rate rather than by the on-rate. Comparison with the complex formed with the TAR* hairpin, a rationally designed TAR RNA ligand (Chang, K. Y., and Tinoco, I. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 8705-8709), demonstrates that the GA pair is a key determinant which accounts for the 50-fold increased stability of the TAR-aptamer complex (K(d) = 2.0 nm) over the TAR-TAR* one (K(d) = 92. 5 nm) at physiological concentration of magnesium. Replacement of the wild-type GC pair next to the loop of RNA I' by a GA pair stabilizes the RNA I'-RNA II' loop-loop complex derived from the one involved in the control of the ColE1 plasmid replication. Thus, the GA pair might be the preferred one for stable loop-loop interactions.

  15. Discrete symmetries in covariant loop quantum gravity

    NASA Astrophysics Data System (ADS)

    Rovelli, Carlo; Wilson-Ewing, Edward

    2012-09-01

    We study time-reversal and parity—on the physical manifold and in internal space—in covariant loop gravity. We consider a minor modification of the Holst action which makes it transform coherently under such transformations. The classical theory is not affected but the quantum theory is slightly different. In particular, the simplicity constraints are slightly modified and this restricts orientation flips in a spin foam to occur only across degenerate regions, thus reducing the sources of potential divergences.

  16. Mangrove Crab Ucides cordatus Removal Does Not Affect Sediment Parameters and Stipule Production in a One Year Experiment in Northern Brazil

    PubMed Central

    2016-01-01

    Mangrove crabs influence ecosystem processes through bioturbation and/or litter feeding. In Brazilian mangroves, the abundant and commercially important crab Ucides cordatus is the main faunal modifier of microtopography establishing up to 2 m deep burrows. They process more than 70% of the leaf litter and propagule production, thus promoting microbial degradation of detritus and benefiting microbe-feeding fiddler crabs. The accelerated nutrient turn-over and increased sediment oxygenation mediated by U. cordatus may enhance mangrove tree growth. Such positive feed-back loop was tested in North Brazil through a one year crab removal experiment simulating increased harvesting rates in a mature Rhizophora mangle forest. Investigated response parameters were sediment salinity, organic matter content, CO2 efflux rates of the surface sediment, and reduction potential. We also determined stipule fall of the mangrove tree R. mangle as a proxy for tree growth. Three treatments were applied to twelve experimental plots (13 m × 13 m each): crab removal, disturbance control and control. Within one year, the number of U. cordatus burrows inside the four removal plots decreased on average to 52% of the initial number. Despite this distinct reduction in burrow density of this large bioturbator, none of the measured parameters differed between treatments. Instead, most parameters were clearly influenced by seasonal changes in precipitation. Hence, in the studied R. mangle forest, abiotic factors seem to be more important drivers of ecosystem processes than factors mediated by U. cordatus, at least within the studied timespan of one year. PMID:27907093

  17. Unraveling the Relationship between Motor Symptoms, Affective States and Contextual Factors in Parkinson’s Disease: A Feasibility Study of the Experience Sampling Method

    PubMed Central

    Kuijf, Mark L.; Van Oostenbrugge, Robert J.; van Os, Jim; Leentjens, Albert F. G.

    2016-01-01

    Background In Parkinson's disease (PD), the complex relationship between motor symptoms, affective states, and contextual factors remains to be elucidated. The Experience Sampling Method provides (ESM) a novel approach to this issue. Using a mobile device with a special purpose application (app), motor symptoms, affective states and contextual factors are assessed repeatedly at random moments in the flow of daily life, yielding an intensive time series of symptoms and experience. The aim of this study was to study the feasibility of this method. Method We studied the feasibility of a five-day period of ESM in PD and its ability to objectify diurnal fluctuations in motor symptom severity and their relation with affect and contextual factors in five PD patients with motor fluctuations. Results Participants achieved a high compliance, with 84% of assessment moments completed without disturbance of daily activities. The utility of the device was rated 8 on a 10-point scale. We were able to capture extensive diurnal fluctuations that were not revealed by routine clinical assessment. In addition, we were able to detect clinically relevant associations between motor symptoms, emotional fluctuations and contextual factors at an intra-individual level. Conclusions ESM represents a viable and novel approach to elucidate relationships between motor symptoms, affective states and contextual factors at the level of individual subjects. ESM holds promise for clinical practice and scientific research. PMID:26962853

  18. Silence and the shaping of memory: how distracted listeners affect speakers' subsequent recall of a computer game experience.

    PubMed

    Pasupathi, Monisha; Hoyt, Tim

    2010-02-01

    The present study focused on how distracted listening affects subsequent memory for narrated events. Undergraduate students experienced a computer game in the lab and talked about it with either a responsive or distracted friend. One month later, those who initially spoke with distracted listeners showed lower retention of information about the computer game, and their subsequent memories were also less consistent with their initial conversational recall. Differences in subsequent memory across initial listener condition appeared likely to be mediated by differences in the initial conversations elicited by responsive and unresponsive listeners. Results are discussed in terms of their implications for the social shaping of memory and identity.

  19. Physiological fluctuations in brain temperature as a factor affecting electrochemical evaluations of extracellular glutamate and glucose in behavioral experiments.

    PubMed

    Kiyatkin, Eugene A; Wakabayashi, Ken T; Lenoir, Magalie

    2013-05-15

    The rate of any chemical reaction or process occurring in the brain depends on temperature. While it is commonly believed that brain temperature is a stable, tightly regulated homeostatic parameter, it fluctuates within 1-4 °C following exposure to salient arousing stimuli and neuroactive drugs, and during different behaviors. These temperature fluctuations should affect neural activity and neural functions, but the extent of this influence on neurochemical measurements in brain tissue of freely moving animals remains unclear. In this Review, we present the results of amperometric evaluations of extracellular glutamate and glucose in awake, behaving rats and discuss how naturally occurring fluctuations in brain temperature affect these measurements. While this temperature contribution appears to be insignificant for glucose because its extracellular concentrations are large, it is a serious factor for electrochemical evaluations of glutamate, which is present in brain tissue at much lower levels, showing smaller phasic fluctuations. We further discuss experimental strategies for controlling the nonspecific chemical and physical contributions to electrochemical currents detected by enzyme-based biosensors to provide greater selectivity and reliability of neurochemical measurements in behaving animals.

  20. Ericaceous dwarf shrubs affect ectomycorrhizal fungal community of the invasive Pinus strobus and native Pinus sylvestris in a pot experiment.

    PubMed

    Kohout, Petr; Sýkorová, Zuzana; Bahram, Mohammad; Hadincová, Věroslava; Albrechtová, Jana; Tedersoo, Leho; Vohník, Martin

    2011-07-01

    This study aimed to elucidate the relationship between ericaceous understorey shrubs and the diversity and abundance of ectomycorrhizal fungi (EcMF) associated with the invasive Pinus strobus and native Pinus sylvestris. Seedlings of both pines were grown in mesocosms and subjected to three treatments simulating different forest microhabitats: (a) grown in isolation and grown with (b) Vaccinium myrtillus or (c) Vaccinium vitis-idaea. Ericaceous plants did not act as a species pool of pine mycobionts and inhibited the ability of the potentially shared species Meliniomyces bicolor to form ectomycorrhizae. Similarly, Ericaceae significantly reduced the formation of Thelephora terrestris ectomycorrhizae in P. sylvestris. EcMF species composition in the mesocosms was strongly affected by both the host species and the presence of an ericaceous neighbour. When grown in isolation, P. strobus root tips were predominantly colonised by Wilcoxina mikolae, whereas those of P. sylvestris were more commonly colonised by Suillus and Rhizopogon spp. Interestingly, these differences were less evident (Suillus + Rhizopogon spp.) or absent (W. mikolae) when the pines were grown with Ericaceae. P. strobus exclusively associated with Rhizopogon salebrosus s.l., suggesting the presence of host specificity at the intrageneric level. Ericaceous plants had a positive effect on colonisation of P. strobus root tips by R. salebrosus s.l. This study demonstrates that the interaction of selective factors such as host species and presence of ericaceous plants may affect the realised niche of the ectomycorrhizal fungi.

  1. Coupled dual loop absorption heat pump

    DOEpatents

    Sarkisian, Paul H.; Reimann, Robert C.; Biermann, Wendell J.

    1985-01-01

    A coupled dual loop absorption system which utilizes two separate complete loops. Each individual loop operates at three temperatures and two pressures. This low temperature loop absorber and condenser are thermally coupled to the high temperature loop evaporator, and the high temperature loop condenser and absorber are thermally coupled to the low temperature generator.

  2. Similarity Metrics for Closed Loop Dynamic Systems

    NASA Technical Reports Server (NTRS)

    Whorton, Mark S.; Yang, Lee C.; Bedrossian, Naz; Hall, Robert A.

    2008-01-01

    To what extent and in what ways can two closed-loop dynamic systems be said to be "similar?" This question arises in a wide range of dynamic systems modeling and control system design applications. For example, bounds on error models are fundamental to the controller optimization with modern control design methods. Metrics such as the structured singular value are direct measures of the degree to which properties such as stability or performance are maintained in the presence of specified uncertainties or variations in the plant model. Similarly, controls-related areas such as system identification, model reduction, and experimental model validation employ measures of similarity between multiple realizations of a dynamic system. Each area has its tools and approaches, with each tool more or less suited for one application or the other. Similarity in the context of closed-loop model validation via flight test is subtly different from error measures in the typical controls oriented application. Whereas similarity in a robust control context relates to plant variation and the attendant affect on stability and performance, in this context similarity metrics are sought that assess the relevance of a dynamic system test for the purpose of validating the stability and performance of a "similar" dynamic system. Similarity in the context of system identification is much more relevant than are robust control analogies in that errors between one dynamic system (the test article) and another (the nominal "design" model) are sought for the purpose of bounding the validity of a model for control design and analysis. Yet system identification typically involves open-loop plant models which are independent of the control system (with the exception of limited developments in closed-loop system identification which is nonetheless focused on obtaining open-loop plant models from closed-loop data). Moreover the objectives of system identification are not the same as a flight test and

  3. Inhibitory Control, but Not Prolonged Object-Related Experience Appears to Affect Physical Problem-Solving Performance of Pet Dogs

    PubMed Central

    Müller, Corsin A.; Riemer, Stefanie; Virányi, Zsófia; Huber, Ludwig; Range, Friederike

    2016-01-01

    Human infants develop an understanding of their physical environment through playful interactions with objects. Similar processes may influence also the performance of non-human animals in physical problem-solving tasks, but to date there is little empirical data to evaluate this hypothesis. In addition or alternatively to prior experiences, inhibitory control has been suggested as a factor underlying the considerable individual differences in performance reported for many species. Here we report a study in which we manipulated the extent of object-related experience for a cohort of dogs (Canis familiaris) of the breed Border Collie over a period of 18 months, and assessed their level of inhibitory control, prior to testing them in a series of four physical problem-solving tasks. We found no evidence that differences in object-related experience explain variability in performance in these tasks. It thus appears that dogs do not transfer knowledge about physical rules from one physical problem-solving task to another, but rather approach each task as a novel problem. Our results, however, suggest that individual performance in these tasks is influenced in a complex way by the subject’s level of inhibitory control. Depending on the task, inhibitory control had a positive or a negative effect on performance and different aspects of inhibitory control turned out to be the best predictors of individual performance in the different tasks. Therefore, studying the interplay between inhibitory control and problem-solving performance will make an important contribution to our understanding of individual and species differences in physical problem-solving performance. PMID:26863141

  4. Inhibitory Control, but Not Prolonged Object-Related Experience Appears to Affect Physical Problem-Solving Performance of Pet Dogs.

    PubMed

    Müller, Corsin A; Riemer, Stefanie; Virányi, Zsófia; Huber, Ludwig; Range, Friederike

    2016-01-01

    Human infants develop an understanding of their physical environment through playful interactions with objects. Similar processes may influence also the performance of non-human animals in physical problem-solving tasks, but to date there is little empirical data to evaluate this hypothesis. In addition or alternatively to prior experiences, inhibitory control has been suggested as a factor underlying the considerable individual differences in performance reported for many species. Here we report a study in which we manipulated the extent of object-related experience for a cohort of dogs (Canis familiaris) of the breed Border Collie over a period of 18 months, and assessed their level of inhibitory control, prior to testing them in a series of four physical problem-solving tasks. We found no evidence that differences in object-related experience explain variability in performance in these tasks. It thus appears that dogs do not transfer knowledge about physical rules from one physical problem-solving task to another, but rather approach each task as a novel problem. Our results, however, suggest that individual performance in these tasks is influenced in a complex way by the subject's level of inhibitory control. Depending on the task, inhibitory control had a positive or a negative effect on performance and different aspects of inhibitory control turned out to be the best predictors of individual performance in the different tasks. Therefore, studying the interplay between inhibitory control and problem-solving performance will make an important contribution to our understanding of individual and species differences in physical problem-solving performance.

  5. Closing the loop.

    PubMed

    Dassau, E; Atlas, E; Phillip, M

    2011-02-01

    Closed-loop algorithms can be found in every aspect of everyday modern life. Automation and control are used constantly to provide safety and to improve quality of life. Closed-loop systems and algorithms can be found in home appliances, automobiles, aviation and more. Can one imagine nowadays driving a car without ABS, cruise control or even anti-sliding control? Similar principles of automation and control can be used in the management of diabetes mellitus (DM). The idea of an algorithmic/technological way to control glycaemia is not new and has been researched for more than four decades. However, recent improvements in both glucose-sensing technology and insulin delivery together with advanced control and systems engineering made this dream of an artificial pancreas possible. The artificial pancreas may be the next big step in the treatment of DM since the use of insulin analogues. An artificial pancreas can be described as internal or external devices that use continuous glucose measurements to automatically manage exogenous insulin delivery with or without other hormones in an attempt to restore glucose regulation in individuals with DM using a control algorithm. This device as described can be internal or external; can use different types of control algorithms with bi-hormonal or uni-hormonal design; and can utilise different ways to administer them. The different designs and implementations have transitioned recently from in silico simulations to clinical evaluation stage with practical applications in mind. This may mark the beginning of a new era in diabetes management with the introduction of semi-closed-loop systems that can prevent or minimise nocturnal hypoglycaemia, to hybrid systems that will manage blood glucose (BG) levels with minimal user intervention to finally fully automated systems that will take the user out of the loop. More and more clinical trials will be needed for the artificial pancreas to become a reality but initial encouraging

  6. Does women's education affect breast cancer risk and survival? Evidence from a population based social experiment in education.

    PubMed

    Palme, Mårten; Simeonova, Emilia

    2015-07-01

    Breast cancer is a notable exception to the well documented positive education gradient in health. A number of studies have found that highly educated women are more likely to be diagnosed with the disease. Breast cancer is therefore often labeled as a "welfare disease". However, it has not been established whether the strong positive correlation holds up when education is exogenously determined. We estimate the causal effect of education on the probability of being diagnosed with breast cancer by exploiting an education reform that extended compulsory schooling and was implemented as a social experiment. We find that the incidence of breast cancer increased for those exposed to the reform.

  7. Complications after Loop Ileostomy Closure: A Retrospective Analysis of 132 Patients

    PubMed Central

    Poskus, Eligijus; Kildusis, Edvinas; Smolskas, Edgaras; Ambrazevicius, Marijus; Strupas, Kestutis

    2014-01-01

    Summary Background Closure of a loop ileostomy is a relatively simple procedure although many studies have demonstrated high morbidity rates following it. Methods to reduce the number of complications, such as timing of closure or different surgical closure techniques, are investigated. The aim of this study was to evaluate the experience of the Abdominal Surgery Center at Vilnius University Hospital (VUH) ‘Santariskiu klinikos’ to review the complications after closure of loop ileostomy and to identify potential risk factors for postoperative complications. Methods Data from 132 patients who underwent closure of loop ileostomy from 2003 to 2013 at the Abdominal Surgery Center of VUH were collected, including demographics, causes of ileostomy formation, additional diseases, time from creation to closure of ileostomy, anastomotic technique, duration of the operation, postoperative complications, and hospital stay after surgery. The operations were performed by 15 surgeons with varying experience assisted by surgical residents. Experience in ileostomy closure was defined by the number of procedures performed. Results Complications occurred in 24 patients (18.2%), with 20 of them having surgical complications: bowel obstruction (9 (6.8%)), wound infection (4 (3.0%)), peritonitis due to anastomotic leak (3 (2.3%)), intra-abdominal abscess (2 (1.5%)), anastomotic leak with enterocutaneous fistula (1 (0.76%)), and bleeding (1 (0.76%)). 4 patients had non-surgical complications: postoperative diarrhea (2 (1.5%)), urinary retention (1 (0.76%)), and deep vein thrombosis (1 (0.76%)). Most complications were classified as group II according to the Clavien-Dindo classification. 2 patients died (1.5%). The anastomotic technique used did not affect the outcome. The experience of the surgeon as judged by the frequency of the procedure was the main factor affecting postoperative morbidity significantly (p = 0.03). Conclusion Our study revealed that the rate of postoperative

  8. Magnetic Field in the Gravitationally Stratified Coronal Loops

    NASA Astrophysics Data System (ADS)

    Dwivedi, B. N.; Srivastava, A. K.

    2015-03-01

    We study the effect of gravitational stratification on the estimation of magnetic fields in the coronal loops. By using the method of MHD seismology of kink waves for the estimation of magnetic field of coronal loops, we derive a new formula for the magnetic field considering the effect of gravitational stratification. The fast-kink wave is a potential diagnostic tool for the estimation of magnetic field in fluxtubes. We consider the eleven kink oscillation cases observed by TRACE between July 1998 and June 2001. We calculate magnetic field in the stratified loops ( B str) and compare them with the previously calculated absolute magnetic field ( B abs). The gravitational stratification efficiently affects the magnetic field estimation in the coronal loops as it affects also the properties of kink waves. We find ≈22% increment in the magnetic field for the smallest ( L = 72 Mm) while ≈ 42% increment in the absolute magnetic field for the longest ( L = 406 Mm) coronal loops. The magnetic fields B str and B abs also increase with the number density, if the loop length does not vary much. The increment in the magnetic field due to gravitational stratification is small at the lower number densities, however, it is large at the higher number densities. We find that damping time of kink waves due to phase-mixing is less in the case of gravitationally stratified loops compared to nonstratified ones. This indicates the more rapid damping of kink waves in the stratified loops. In conclusion, we find that the gravitational stratification efficiently affects the estimation of magnetic field and damping time estimation especially in the longer coronal loops.

  9. Understanding how drivers learn to anticipate risk on the road: A laboratory experiment of affective anticipation of road hazards.

    PubMed

    Kinnear, Neale; Kelly, Steve W; Stradling, Stephen; Thomson, James

    2013-01-01

    This study examines whether there is evidence that converging theories from the domains of risk and decision making, neuroscience, and psychology can improve our understanding of how drivers learn to appraise on-the-road hazards. Within the domain of decision making it is suggested that there are two distinct ways in which humans appraise risk: risk as feelings and risk as analysis. Meanwhile, current neurological theory, in the form of the Somatic Marker Hypothesis, supports the role of feelings and emotion as an evolved automated system of human risk appraisal that biases judgment and decision making. This study used skin conductance responses (SCRs) to measure learner, novice and experienced drivers' psycho-physiological responses to the development of driving hazards. Experienced drivers were twice as likely to produce an SCR to developing hazards as novice drivers and three times as likely when compared with learner drivers. These differences maintained significance when age, gender and exposure were controlled for. Further analysis revealed that novice drivers who had less than 1000 miles driving experience had anticipatory physiological responses similar to learner drivers, whereas novices who had driven more than 1000 miles had scores approaching those of experienced drivers. This demonstrated a learning curve mediated by driving experience supporting experiential learning as proposed within the Somatic Marker Hypothesis. A differentiation between cognitive and psycho-physiological responses was also found supporting theory that distinguishes between conscious and non-conscious risk appraisal.

  10. Experience-Driven Differences in Childhood Cortisol Predict Affect-Relevant Brain Function and Coping in Adolescent Monozygotic Twins

    PubMed Central

    Burghy, Cory A.; Fox, Michelle E.; Cornejo, M. Daniela; Stodola, Diane E.; Sommerfeldt, Sasha L.; Westbrook, Cecilia A.; Van Hulle, Carol; Schmidt, Nicole L.; Goldsmith, H. Hill; Davidson, Richard J.; Birn, Rasmus M.

    2016-01-01

    Stress and emotion involve diverse developmental and individual differences. Partially attributed to the development of the prefrontal cortex (PFC), the amygdala, and hypothalamic-pituitary-adrenal axis, the precise genetic and experiential contributions remain unknown. In previous work, childhood basal cortisol function predicted adolescent resting-state functional connectivity (rs-FC) and psychopathology. To parse experience-driven (non-genetic) contributions, we investigated these relations with a monozygotic (MZ) twin design. Specifically, we examined whether intrapair differences in childhood afternoon cortisol levels predicted cotwin differences in adolescent brain function and coping. As expected, intrapair differences in childhood cortisol forecast amygdala-perigenual PFC rs-FC (R2 = 0.84, FWE-corrected p = 0.01), and amygdala recovery following unpleasant images (R2 = 0.40, FWE-corrected p < 0.05), such that the cotwin with higher childhood cortisol evinced relatively lower rs-FC and poorer amygdala recovery in adolescence. Cotwin differences in amygdala recovery also predicted coping styles. These data highlight experience-dependent change in childhood and adolescence. PMID:27872489

  11. How Body Orientation Affects Concepts of Space, Time and Valence: Functional Relevance of Integrating Sensorimotor Experiences during Word Processing

    PubMed Central

    Ruiz Fernandez, Susana; Bury, Nils-Alexander; Gerjets, Peter; Fischer, Martin H.; Bock, Otmar L.

    2016-01-01

    The aim of the present study was to test the functional relevance of the spatial concepts UP or DOWN for words that use these concepts either literally (space) or metaphorically (time, valence). A functional relevance would imply a symmetrical relationship between the spatial concepts and words related to these concepts, showing that processing words activate the related spatial concepts on one hand, but also that an activation of the concepts will ease the retrieval of a related word on the other. For the latter, the rotation angle of participant’s body position was manipulated either to an upright or a head-down tilted body position to activate the related spatial concept. Afterwards participants produced in a within-subject design previously memorized words of the concepts space, time and valence according to the pace of a metronome. All words were related either to the spatial concept UP or DOWN. The results including Bayesian analyses show (1) a significant interaction between body position and words using the concepts UP and DOWN literally, (2) a marginal significant interaction between body position and temporal words and (3) no effect between body position and valence words. However, post-hoc analyses suggest no difference between experiments. Thus, the authors concluded that integrating sensorimotor experiences is indeed of functional relevance for all three concepts of space, time and valence. However, the strength of this functional relevance depends on how close words are linked to mental concepts representing vertical space. PMID:27812155

  12. Loop expansion and the bosonic representation of loop quantum gravity

    NASA Astrophysics Data System (ADS)

    Bianchi, E.; Guglielmon, J.; Hackl, L.; Yokomizo, N.

    2016-10-01

    We introduce a new loop expansion that provides a resolution of the identity in the Hilbert space of loop quantum gravity on a fixed graph. We work in the bosonic representation obtained by the canonical quantization of the spinorial formalism. The resolution of the identity gives a tool for implementing the projection of states in the full bosonic representation onto the space of solutions to the Gauss and area matching constraints of loop quantum gravity. This procedure is particularly efficient in the semiclassical regime, leading to explicit expressions for the loop expansions of coherent, heat kernel and squeezed states.

  13. High temperature storage loop :

    SciTech Connect

    Gill, David Dennis; Kolb, William J.

    2013-07-01

    A three year plan for thermal energy storage (TES) research was created at Sandia National Laboratories in the spring of 2012. This plan included a strategic goal of providing test capability for Sandia and for the nation in which to evaluate high temperature storage (>650ÀC) technology. The plan was to scope, design, and build a flow loop that would be compatible with a multitude of high temperature heat transfer/storage fluids. The High Temperature Storage Loop (HTSL) would be reconfigurable so that it was useful for not only storage testing, but also for high temperature receiver testing and high efficiency power cycle testing as well. In that way, HTSL was part of a much larger strategy for Sandia to provide a research and testing platform that would be integral for the evaluation of individual technologies funded under the SunShot program. DOEs SunShot program seeks to reduce the price of solar technologies to 6/kWhr to be cost competitive with carbon-based fuels. The HTSL project sought to provide evaluation capability for these SunShot supported technologies. This report includes the scoping, design, and budgetary costing aspects of this effort

  14. Ekpyrotic loop quantum cosmology

    SciTech Connect

    Wilson-Ewing, Edward

    2013-08-01

    We consider the ekpyrotic paradigm in the context of loop quantum cosmology. In loop quantum cosmology the classical big-bang singularity is resolved due to quantum gravity effects, and so the contracting ekpyrotic branch of the universe and its later expanding phase are connected by a smooth bounce. Thus, it is possible to explicitly determine the evolution of scalar perturbations, from the contracting ekpyrotic phase through the bounce and to the post-bounce expanding epoch. The possibilities of having either one or two scalar fields have been suggested for the ekpyrotic universe, and both cases will be considered here. In the case of a single scalar field, the constant mode of the curvature perturbations after the bounce is found to have a blue spectrum. On the other hand, for the two scalar field ekpyrotic model where scale-invariant entropy perturbations source additional terms in the curvature perturbations, the power spectrum in the post-bounce expanding cosmology is shown to be nearly scale-invariant and so agrees with observations.

  15. Atmospheric CO2 level affects plants' carbon use efficiency: insights from a 13C labeling experiment on sunflower stands

    NASA Astrophysics Data System (ADS)

    Gong, Xiaoying; Schäufele, Rudi; Schnyder, Hans

    2015-04-01

    The increase of atmospheric CO2 concentration has been shown to stimulate plant photosynthesis and (to a lesser extent) growth, thereby acting as a possible sink for the additional atmospheric CO2. However, this effect is dependent on the efficiency with which plants convert atmospheric carbon into biomass carbon, since a considerable proportion of assimilated carbon is returned to the atmosphere via plant respiration. As a core parameter for carbon cycling, carbon use efficiency of plants (CUE, the ratio of net primary production to gross primary production) quantifies the proportion of assimilated carbon that is incorporated into plant biomass. CUE has rarely been assessed based on measurements of complete carbon balance, due to methodological difficulties in measuring respiration rate of plants in light. Moreover, foliar respiration is known to be inhibited in light, thus foliar respiration rate is generally lower in light than in dark. However, this phenomenon, termed as inhibition of respiration in light (IRL), has rarely been assessed at the stand-scale and been incorporated into the calculation of CUE. Therefore, how CUE responses to atmospheric CO2 levels is still not clear. We studied CUE of sunflower stands grown at sub-ambient CO2 level (200 μmol mol-1) and elevated CO2 level (1000 μmol mol-1) using mesocosm-scale gas exchange facilities which enabled continuous measurements of 13CO2/12CO2 exchange. Appling steady-state 13C labeling, fluxes of respiration and photosynthesis in light were separated, and tracer kinetic in respiration was analyzed. This study provides the first data on CUE at a mesocosm-level including respiration in light in different CO2 environments. We found that CUE of sunflower was lower at an elevated CO2 level than at a sub-ambient CO2 level; and the ignorance of IRL lead to erroneous estimations of CUE. Variation in CUE at atmospheric CO2 levels was attributed to several mechanisms. In this study, CO2 enrichment i) affected the

  16. Sexual experience and temperament affect the response of Merino ewes to the ram effect during the anoestrous season.

    PubMed

    Chanvallon, A; Blache, D; Chadwick, A; Esmaili, T; Hawken, P A R; Martin, G B; Viñoles, C; Fabre-Nys, C

    2010-06-01

    In seasonally anoestrous ewes of many breeds, the introduction of rams triggers an increase in gonadotrophin secretion that induces ovulation, a phenomenon known as the 'ram effect'. The ram effect is a practical method for mating ewes outside the natural breeding season, and also can provide synchronised lambing, but the variability of the response, especially in young animals, reduces its potential for widespread application. The aim of our study was to assess two factors that are thought to contribute to the variability in young ewes: temperament and sexual experience. We used anovulatory ewes from a flock that had been genetically selected for 'calm' or 'nervous' temperament and compared the endocrine and ovarian responses to the ram effect in four groups (each n=15): 'calm' and parous (3-6 years old); 'calm' and nulliparous (2 years old); 'nervous' and parous; and 'nervous' and nulliparous. Parous ewes, independently of their temperament, exhibited a faster endocrine response and a higher proportion of females cycling after ram introduction than nulliparous ewes. 'Nervous' ewes exhibited a higher proportion of females cycling after ram introduction than calm ewes, but only in the nulliparous group. We conclude that temperament exerts little influence on the response to the ram effect in sexually experienced ewes, and that females of 'nervous' temperament appear to respond better when sexually 'naive'. Both sexual experience and temperament need to be taken into consideration when flock management involves the ram effect. Finally, some ewes were cyclic at ram introduction, yet exhibited an increase in LH secretion even in the presence of high concentrations of progesterone. The mechanism by which the inhibitory effect of progesterone on LH secretion was bypassed needs to be clarified.

  17. Feeding Experience Affects the Behavioral Response of Polyphagous Gypsy Moth Caterpillars to Herbivore-induced Poplar Volatiles.

    PubMed

    McCormick, Andrea C; Reinecke, Andreas; Gershenzon, Jonathan; Unsicker, Sybille B

    2016-05-01

    Plant volatiles influence host selection of herbivorous insects. Since volatiles often vary in space and time, herbivores (especially polyphagous ones) may be able to use these compounds as cues to track variation in host plant quality based on their innate abilities and previous experience. We investigated the behavioral response of naïve (fed on artificial diet) and experienced (fed on poplar) gypsy moth (Lymantria dispar) caterpillars, a polyphagous species, towards constitutive and herbivore-induced black poplar (Populus nigra) volatiles at different stages of herbivore attack. In Y-tube olfactometer assays, both naïve and experienced caterpillars were attracted to constitutive volatiles and volatiles released after short-term herbivory (up to 6 hr). Naïve caterpillars also were attracted to volatiles released after longer-term herbivory (24-30 hr), but experienced caterpillars preferred the odor of undamaged foliage. A multivariate statistical analysis comparing the volatile emission of undamaged plants vs. plants after short and longer-term herbivory, suggested various compounds as being responsible for distinguishing between the odors of these plants. Ten compounds were selected for individual testing of caterpillar behavioral responses in a four-arm olfactometer. Naïve caterpillars spent more time in arms containing (Z)-3-hexenol and (Z)-3-hexenyl acetate than in solvent permeated arms, while avoiding benzyl cyanide and salicyl aldehyde. Experienced caterpillars avoided benzyl cyanide and preferred (Z)-3-hexenyl acetate and the homoterpene (E)-4,8-dimethyl-1,3,7-nonatriene (DMNT) over solvent. Only responses to DMNT were significantly different when comparing experienced and naïve caterpillars. The results show that gypsy moth caterpillars display an innate behavioral response towards constitutive and herbivore-induced plant volatiles, but also that larval behavior is plastic and can be modulated by previous feeding experience.

  18. THE NEW U. S. IMMIGRANTS: HOW DO THEY AFFECT OUR UNDERSTANDING OF THE AFRICAN-AMERICAN EXPERIENCE?

    PubMed Central

    Bean, Frank D.; Feliciano, Cynthia; Lee, Jennifer; Van Hook, Jennifer

    2011-01-01

    The implications of recent immigration for race relations in the United States depend importantly on family cultural orientations among Mexican Americans and how this group is culturally perceived by Anglos. Because Moynihan's 1965 work (in)famously emphasized the need to change black family culture in order to ameliorate black poverty, his work still holds implications for understanding how cultural orientations affect changing color lines. Unfortunately, his partially insightful analyses inadequately foresaw that policies designed to alleviate poverty through the modification of family cultural patterns are likely to fail without parallel changes in structural opportunities. Similar limitations also often emerge from mis-characterizations of Mexican origin family cultural situations, which all too often are incongruously reified as either being unduly familistic (thus falsely implying Mexican origin families foster self-sufficiency) or largely governed by culture of poverty tendencies (thus inaccurately suggesting Mexican origin families depend on welfare). Here we review research suggesting that Mexican origin families are neither substantially familistic nor disproportionately susceptible to moral hazard, thus indicating that future Mexican origin economic advancement is likely to turn on the availability of structural opportunities. In-depth interviews with Anglos further suggest that Mexicans are not culturally viewed with the same degree of prejudice and discrimination as blacks, implying that the integration of Mexicans into American society, contingent on adequate economic opportunity, will probably progress more steadily than often feared, while that of blacks may proceed more slowly than often expected. PMID:22199397

  19. The double loop mattress suture

    PubMed Central

    Biddlestone, John; Samuel, Madan; Creagh, Terry; Ahmad, Tariq

    2014-01-01

    An interrupted stitch type with favorable tissue characteristics will reduce local wound complications. We describe a novel high-strength, low-tension repair for the interrupted closure of skin, cartilage, and muscle, the double loop mattress stitch, and compare it experimentally with other interrupted closure methods. The performance of the double loop mattress technique in porcine cartilage and skeletal muscle is compared with the simple, mattress, and loop mattress interrupted sutures in both a novel porcine loading chamber and mechanical model. Wound apposition is assessed by electron microscopy. The performance of the double loop mattress in vivo was confirmed using a series of 805 pediatric laparotomies/laparoscopies. The double loop mattress suture is 3.5 times stronger than the loop mattress in muscle and 1.6 times stronger in cartilage (p ≤ 0.001). Additionally, the double loop mattress reduces tissue tension by 66% compared with just 53% for the loop mattress (p ≤ 0.001). Wound gapping is equal, and wound eversion appears significantly improved (p ≤ 0.001) compared with the loop mattress in vitro. In vivo, the double loop mattress performs as well as the loop mattress and significantly better than the mattress stitch in assessments of wound eversion and dehiscence. There were no episodes of stitch extrusion in our series of patients. The mechanical advantage of its intrinsic pulley arrangement gives the double loop mattress its favorable properties. Wound dehiscence is reduced because this stitch type is stronger and exerts less tension on the tissue than the mattress stitch. We advocate the use of this novel stitch wherever a high-strength, low-tension repair is required. These properties will enhance wound repair, and its application will be useful to surgeons of all disciplines. PMID:24698436

  20. Heterotrophic respiration in drained tropical peat is greatly affected by temperature—a passive ecosystem cooling experiment

    NASA Astrophysics Data System (ADS)

    Jauhiainen, Jyrki; Kerojoki, Otto; Silvennoinen, Hanna; Limin, Suwido; Vasander, Harri

    2014-10-01

    Vast areas of deforested tropical peatlands do not receive noteworthy shading by vegetation, which increases the amount of solar radiation reaching the peat surface. Peat temperature dynamics and heterotrophic carbon dioxide (CO2), nitrous oxide (N2O) and methane (CH4) fluxes were monitored under four shading conditions, i.e. unshaded, 28%, 51% and 90% shading at experiment sites established on reclaimed fallow agricultural- and degraded sites in Central Kalimantan, Indonesia. Groundwater tables on the sites were at about 50 cm depth, the sites were maintained vegetation free and root ingrowth to gas flux monitoring locations was prevented. Half of the four shading areas received NPK-fertilization 50 kg ha-1 for each of N, P and K during the experiment and the other half was unfertilized. Increases in shading created a lasting decrease in peat temperatures, and decreased diurnal temperature fluctuations, in comparison to less shaded plots. The largest peat temperature difference in the topmost 50 cm peat profile was between the unshaded and 90% shaded surface, where the average temperatures at 5 cm depth differed up to 3.7 °C, and diurnal temperatures at 5 cm depth varied up to 4.2 °C in the unshaded and 0.4 °C in the 90% shaded conditions. Highest impacts on the heterotrophic CO2 fluxes caused by the treatments were on agricultural land, where 90% shading from the full exposure resulted in a 33% lower CO2 emission average on the unfertilized plots and a 66% lower emission average on the fertilized plots. Correlation between peat temperature and CO2 flux suggested an approximately 8% (unfertilized) and 25% (fertilized) emissions change for each 1 °C temperature change at 5 cm depth on the agricultural land. CO2 flux responses to the treatments remained low on degraded peatland. Fertilized conditions negatively correlated with N2O efflux with increases in temperature, suggesting a 12-36% lower efflux for each 1 °C increase in peat temperature (at 5 cm depth) at

  1. Enhancement of surface nonwettability by grafting loops.

    PubMed

    Pei, Han-Wen; Liu, Xiao-Li; Liu, Hong; Zhu, You-Liang; Lu, Zhong-Yuan

    2017-02-08

    We present a computer simulation study on the nonwettability of a flat surface tethered with deformable looped polymer chains. Two kinds of loops are studied: monodispersed loops (loops with the same length) and polydispersed loops (loops with different lengths). Both kinds of loops include two arrangements: with regularly tethered sites and with randomly tethered sites. Regularly grafted loops form typical grooves on the surface, while randomly grafted loops form a more rugged surface. For monodispersed loops, we analyze the factors that influence the nonwettability when varying the rigidity of the loops. The loops are divided into two categories based on their rigidity according to our previous analysis procedure (Phys. Chem. Chem. Phys., 2016, 18, 18767-18775): rigid loops and flexible loops. It is found that the loop can partially form a re-entrant-like structure, which is helpful to increase the nonwettability of the surface. The surfaces with grafted loops have increased nonwettability, especially those grafted with flexible chains. However, the contact angle on the loop structure cannot further increase for the rigid chains due to a large top layer density (Phys. Chem. Chem. Phys., 2016, 18, 18767-18775). For polydispersed loops, the contact angle is highly related to the rigidity of the long loops that contact the droplet. Different from monodispersed loops, the mechanism of the nonwettability of polydispersed loops is attributed to the supporting ability (rigidity) of long loops.

  2. Alternative DNA loops regulate the arabinose operon in Escherichia coli.

    PubMed

    Huo, L; Martin, K J; Schleif, R

    1988-08-01

    The araCBAD regulatory region of Escherichia coli contains two divergently oriented promoters and three sites to which AraC, the regulatory protein of the operon, can bind. This paper presents the results of in vivo dimethyl sulfate "footprinting" experiments to monitor occupancy of the three AraC sites and measurements of activity of the two promoters. These measurements were made both in the absence of the inducer arabinose and at various times after arabinose addition to growing cells containing the wild-type ara regulatory region or the regulatory region containing various deletions and point mutations. The data lead to the conclusion that two different DNA loops can form in the ara regulatory region. These loops are generated by AraC protein molecules binding to two different DNA sites and binding to each other. One of these loops predominates in the absence of arabinose and plays a major role in repressing activity of one of the promoters. Upon the addition of arabinose the amount of the first loop type, the repression loop, decreases and the amount of a second loop increases. Formation of this second loop precludes the counterproductive formation of the repression loop.

  3. Motor imagery of locomotion with an additional load: actual load experience does not affect differences between physical and mental durations.

    PubMed

    Munzert, Jörn; Blischke, Klaus; Krüger, Britta

    2015-03-01

    Motor imagery relies strongly on motor representations. Currently, it is widely accepted that both the imagery and execution of actions share the same neural representations (Jeannerod, Neuroimage 14:S103-S109, 2001). Comparing mental with actual movement durations opens a window through which to examine motor representations and how they relate to cognitive motor processes. The present experiment examined mental durations reported by participants standing upright who imagined walking either with or without an additional load while actually carrying or not carrying that same load. Results showed a robust effect of longer durations when imagining the additional load during mental walking, whereas physical walking with an additional load did not extend movement durations accordingly. However, experiencing an actual load during imagery did not influence mental durations substantially. This dissociation of load-related effects can be interpreted as being due to an interaction of motor processes and their cognitive representation along with a reduction in neural activity in vestibular and somatosensory areas during imagery of locomotion. It is argued that this effect might be specific to locomotion and not generalize to a broader range of movements.

  4. The Dynamic Reactance Interaction – How Vested Interests Affect People’s Experience, Behavior, and Cognition in Social Interactions

    PubMed Central

    Steindl, Christina; Jonas, Eva

    2015-01-01

    In social interactions, individuals may sometimes pursue their own interests at the expense of their interaction partner. Such self-interested behaviors impose a threat to the interaction partner’s freedom to act. The current article investigates this threat in the context of interdependence and reactance theory. We explore how vested interests influence reactance process stages of an advisor–client interaction. We aim to explore the interactional process that evolves. In two studies, participants took the perspective of a doctor (advisor) or a patient (client). In both studies we incorporated a vested interest. In Study 1 (N = 82) we found that in response to a vested interest of their interaction partner, patients indicated a stronger experience of reactance, more aggressive behavioral intentions, and more biased cognitions than doctors. A serial multiple mediation revealed that a vested interest engendered mistrust toward the interaction partner and this mistrust led to an emerging reactance process. Study 2 (N = 207) further demonstrated that doctors expressed their reactance in a subtle way: they revealed a classic confirmation bias when searching for additional information on their preliminary decision preference, indicating stronger defense motivation. We discuss how these findings can help us to understand how social interactions develop dynamically. PMID:26640444

  5. Contingency learning is not affected by conflict experience: Evidence from a task conflict-free, item-specific Stroop paradigm.

    PubMed

    Levin, Yulia; Tzelgov, Joseph

    2016-02-01

    A contingency learning account of the item-specific proportion congruent effect has been described as an associative stimulus-response learning process that has nothing to do with controlling the Stroop conflict. As supportive evidence, contingency learning has been demonstrated with response conflict-free stimuli, such as neutral words. However, what gives rise to response conflict and to Stroop interference in general is task conflict. The present study investigated whether task conflict can constitute a trigger or, alternatively, a booster to the contingency learning process. This was done by employing a "task conflict-free" condition (i.e., geometric shapes) and comparing it with a "task conflict" condition (i.e., neutral words). The results showed a significant contingency learning effect in both conditions, refuting the possibility that contingency learning is triggered by the presence of a task conflict. Contingency learning was also not enhanced by the task conflict experience, indicating its complete insensitivity to Stroop conflict(s). Thus, the results showed no evidence that performance optimization as a result of contingency learning is greater under conflict, implying that contingency learning is not recruited to assist the control system to overcome conflict.

  6. Unstable anisotropic loop quantum cosmology

    SciTech Connect

    Nelson, William; Sakellariadou, Mairi

    2009-09-15

    We study stability conditions of the full Hamiltonian constraint equation describing the quantum dynamics of the diagonal Bianchi I model in the context of loop quantum cosmology. Our analysis has shown robust evidence of an instability in the explicit implementation of the difference equation, implying important consequences for the correspondence between the full loop quantum gravity theory and loop quantum cosmology. As a result, one may question the choice of the quantization approach, the model of lattice refinement, and/or the role of the ambiguity parameters; all these should, in principle, be dictated by the full loop quantum gravity theory.

  7. Loop-the-Loop: Bringing Theory into Practice

    ERIC Educational Resources Information Center

    Suwonjandee, N.; Asavapibhop, B.

    2012-01-01

    During the Thai high-school physics teacher training programme, we used an aluminum loop-the-loop system built by the Institute for the Promotion of Teaching Science and Technology (IPST) to demonstrate a circular motion and investigate the concept of the conservation of mechanical energy. There were 27 high-school teachers from three provinces,…

  8. Formation of chromosomal domains in interphase by loop extrusion

    NASA Astrophysics Data System (ADS)

    Fudenberg, Geoffrey

    While genomes are often considered as one-dimensional sequences, interphase chromosomes are organized in three dimensions with an essential role for regulating gene expression. Recent studies have shown that Topologically Associating Domains (TADs) are fundamental structural and functional building blocks of human interphase chromosomes. Despite observations that architectural proteins, including CTCF, demarcate and maintain the borders of TADs, the mechanisms underlying TAD formation remain unknown. Here we propose that loop extrusion underlies the formation TADs. In this process, cis-acting loop-extruding factors, likely cohesins, form progressively larger loops, but stall at TAD boundaries due to interactions with boundary proteins, including CTCF. This process dynamically forms loops of various sizes within but not between TADs. Using polymer simulations, we find that loop extrusion can produce TADs as determined by our analyses of the highest-resolution experimental data. Moreover, we find that loop extrusion can explain many diverse experimental observations, including: the preferential orientation of CTCF motifs and enrichments of architectural proteins at TAD boundaries; TAD boundary deletion experiments; and experiments with knockdown or depletion of CTCF, cohesin, and cohesin-loading factors. Together, the emerging picture from our work is that TADs are formed by rapidly associating, growing, and dissociating loops, presenting a clear framework for understanding interphase chromosomal organization.

  9. Dynamic PID loop control

    SciTech Connect

    Pei, L.; Klebaner, A.; Theilacker, J.; Soyars, W.; Martinez, A.; Bossert, R.; DeGraff, B.; Darve, C.; /Fermilab

    2011-06-01

    The Horizontal Test Stand (HTS) SRF Cavity and Cryomodule 1 (CM1) of eight 9-cell, 1.3GHz SRF cavities are operating at Fermilab. For the cryogenic control system, how to hold liquid level constant in the cryostat by regulation of its Joule-Thompson JT-valve is very important after cryostat cool down to 2.0 K. The 72-cell cryostat liquid level response generally takes a long time delay after regulating its JT-valve; therefore, typical PID control loop should result in some cryostat parameter oscillations. This paper presents a type of PID parameter self-optimal and Time-Delay control method used to reduce cryogenic system parameters oscillation.

  10. Pulse thermal loop

    NASA Technical Reports Server (NTRS)

    Weislogel, Mark M. (Inventor)

    2002-01-01

    A pulse thermal loop heat transfer system includes a means to use pressure rises in a pair of evaporators to circulate a heat transfer fluid. The system includes one or more valves that iteratively, alternately couple the outlets the evaporators to the condenser. While flow proceeds from one of the evaporators to the condenser, heating creates a pressure rise in the other evaporator, which has its outlet blocked to prevent fluid from exiting the other evaporator. When the flow path is reconfigured to allow flow from the other evaporator to the condenser, the pressure in the other evaporator is used to circulate a pulse of fluid through the system. The reconfiguring of the flow path, by actuating or otherwise changing the configuration of the one or more valves, may be triggered when a predetermined pressure difference between the evaporators is reached.

  11. Vortex loops and Majoranas

    SciTech Connect

    Chesi, Stefano; Jaffe, Arthur; Loss, Daniel; Pedrocchi, Fabio L.

    2013-11-15

    We investigate the role that vortex loops play in characterizing eigenstates of interacting Majoranas. We give some general results and then focus on ladder Hamiltonian examples as a test of further ideas. Two methods yield exact results: (i) A mapping of certain spin Hamiltonians to quartic interactions of Majoranas shows that the spectra of these two examples coincide. (ii) In cases with reflection-symmetric Hamiltonians, we use reflection positivity for Majoranas to characterize vortices in the ground states. Two additional methods suggest wider applicability of these results: (iii) Numerical evidence suggests similar behavior for certain systems without reflection symmetry. (iv) A perturbative analysis also suggests similar behavior without the assumption of reflection symmetry.

  12. Loop Quantum Gravity.

    PubMed

    Rovelli, Carlo

    2008-01-01

    The problem of describing the quantum behavior of gravity, and thus understanding quantum spacetime, is still open. Loop quantum gravity is a well-developed approach to this problem. It is a mathematically well-defined background-independent quantization of general relativity, with its conventional matter couplings. Today research in loop quantum gravity forms a vast area, ranging from mathematical foundations to physical applications. Among the most significant results obtained so far are: (i) The computation of the spectra of geometrical quantities such as area and volume, which yield tentative quantitative predictions for Planck-scale physics. (ii) A physical picture of the microstructure of quantum spacetime, characterized by Planck-scale discreteness. Discreteness emerges as a standard quantum effect from the discrete spectra, and provides a mathematical realization of Wheeler's "spacetime foam" intuition. (iii) Control of spacetime singularities, such as those in the interior of black holes and the cosmological one. This, in particular, has opened up the possibility of a theoretical investigation into the very early universe and the spacetime regions beyond the Big Bang. (iv) A derivation of the Bekenstein-Hawking black-hole entropy. (v) Low-energy calculations, yielding n-point functions well defined in a background-independent context. The theory is at the roots of, or strictly related to, a number of formalisms that have been developed for describing background-independent quantum field theory, such as spin foams, group field theory, causal spin networks, and others. I give here a general overview of ideas, techniques, results and open problems of this candidate theory of quantum gravity, and a guide to the relevant literature.

  13. Uranyl Nitrate Flow Loop

    SciTech Connect

    Ladd-Lively, Jennifer L

    2008-10-01

    The objectives of the work discussed in this report were to: (1) develop a flow loop that would simulate the purified uranium-bearing aqueous stream exiting the solvent extraction process in a natural uranium conversion plant (NUCP); (2) develop a test plan that would simulate normal operation and disturbances that could be anticipated in an NUCP; (3) use the flow loop to test commercially available flowmeters for use as safeguards monitors; and (4) recommend a flowmeter for production-scale testing at an NUCP. There has been interest in safeguarding conversion plants because the intermediate products [uranium dioxide (UO{sub 2}), uranium tetrafluoride (UF{sub 4}), and uranium hexafluoride (UF{sub 6})] are all suitable uranium feedstocks for producing special nuclear materials. Furthermore, if safeguards are not applied virtually any nuclear weapons program can obtain these feedstocks without detection by the International Atomic Energy Agency (IAEA). Historically, IAEA had not implemented safeguards until the purified UF{sub 6} product was declared as feedstock for enrichment plants. H. A. Elayat et al. provide a basic definition of a safeguards system: 'The function of a safeguards system on a chemical conversion plant is in general terms to verify that no useful nuclear material is being diverted to use in a nuclear weapons program'. The IAEA now considers all highly purified uranium compounds as candidates for safeguarding. DOE is currently interested in 'developing instruments, tools, strategies, and methods that could be of use to the IAEA in the application of safeguards' for materials found in the front end of the nuclear fuel cycle-prior to the production of the uranium hexafluoride or oxides that have been the traditional starting point for IAEA safeguards. Several national laboratories, including Oak Ridge, Los Alamos, Lawrence Livermore, and Brookhaven, have been involved in developing tools or techniques for safeguarding conversion plants. This study

  14. Embodying Deficiency Through ‘Affective Practice’: Shame, Relationality, and the Lived Experience of Social Class and Gender in Higher Education

    PubMed Central

    Loveday, Vik

    2015-01-01

    Based on empirical research with participants from working-class backgrounds studying and working in higher education in England, this article examines the lived experience of shame. Building on a feminist Bourdieusian approach to social class analysis, the article contends that ‘struggles for value’ within the field of higher education precipitate classed judgements, which have the potential to generate shame. Through an examination of the ‘affective practice’ of judgement, the article explores the contingencies that precipitate shame and the embodiment of deficiency. The article links the classed and gendered dimensions of shame with valuation, arguing that the fundamental relationality of social class and gender is not only generative of shame, but that shame helps in turn to structure both working-class experience and a view of the working classes as ‘deficient’. PMID:28018006

  15. Soil seed banks and their germination responses to cadmium and salinity stresses in coastal wetlands affected by reclamation and urbanization based on indoor and outdoor experiments.

    PubMed

    Bai, Junhong; Huang, Laibin; Gao, Zhaoqin; Lu, Qiongqiong; Wang, Junjing; Zhao, Qingqing

    2014-09-15

    Indoor and outdoor seedling emergence experiments were conducted to thoroughly investigate germination patterns as affected by reclamation and urbanization, the ecological characteristics of soil seed banks, and their relationships with environmental factors in both urbanized and reclaimed regions of the Pearl River Delta in coastal wetlands. The germination rate of the soil seed bank was higher in the indoor experiment compared with that in the outdoor experiment, whereas the number and destiny of the germinated seedlings were greater in the outdoor experiment. The species diversity and number, as well as the richness and evenness indices, were higher in the urbanized region compared with the reclaimed region. However, the dominance and Sørensen similarity indices were greater in the reclaimed region compared with those indices in the urbanized region. Higher salinity and Cadmium (Cd) levels could inhibit seed germination; however, their suitable ranges (i.e. [0-2,000 mg kg(-1)] for salinity and [0-4.0 mg kg(-1)] for available Cd) can activate seedling emergence, and more seedlings germinated under the intersectional levels at 0.34 mg kg(-1) available Cd and 778.6 mg kg(-1) salinity. Seawater intrusion caused by the sea level rise will possibly result in the salt-tolerant community in this area due to increasing salinity.

  16. RCD+: Fast loop modeling server

    PubMed Central

    López-Blanco, José Ramón; Canosa-Valls, Alejandro Jesús; Li, Yaohang; Chacón, Pablo

    2016-01-01

    Modeling loops is a critical and challenging step in protein modeling and prediction. We have developed a quick online service (http://rcd.chaconlab.org) for ab initio loop modeling combining a coarse-grained conformational search with a full-atom refinement. Our original Random Coordinate Descent (RCD) loop closure algorithm has been greatly improved to enrich the sampling distribution towards near-native conformations. These improvements include a new workflow optimization, MPI-parallelization and fast backbone angle sampling based on neighbor-dependent Ramachandran probability distributions. The server starts by efficiently searching the vast conformational space from only the loop sequence information and the environment atomic coordinates. The generated closed loop models are subsequently ranked using a fast distance-orientation dependent energy filter. Top ranked loops are refined with the Rosetta energy function to obtain accurate all-atom predictions that can be interactively inspected in an user-friendly web interface. Using standard benchmarks, the average root mean squared deviation (RMSD) is 0.8 and 1.4 Å for 8 and 12 residues loops, respectively, in the challenging modeling scenario in where the side chains of the loop environment are fully remodeled. These results are not only very competitive compared to those obtained with public state of the art methods, but also they are obtained ∼10-fold faster. PMID:27151199

  17. Improved code-tracking loop

    NASA Technical Reports Server (NTRS)

    Laflame, D. T.

    1980-01-01

    Delay-locked loop tracks pseudonoise codes without introducing dc timing errors, because it is not sensitive to gain imbalance between signal processing arms. "Early" and "late" reference codes pass in combined form through both arms, and each arm acts on both codes. Circuit accomodates 1 dB weaker input signals with tracking ability equal to that of tau-dither loops.

  18. Experiences in the management of anastomotic leakages and analysis of the factors affecting leakage healing in patients with esophagogastric junction cancer

    PubMed Central

    Ding, Ningning; He, Jie; Gao, Shugeng; Zhao, Yue; Yang, Ding; Sun, Kelin; Cheng, Guiyu; Mu, Juwei; Xue, Qi; Wang, Dali; Zhao, Jun; Gao, Yushun; Liu, Xiangyang; Fang, Dekang; Li, Jian; Wang, Yonggang; Huang, Jinfeng; Wang, Bing; Zhang, Liangze

    2017-01-01

    Background It was reported in the literatures that the incidence of anastomotic leakage in patients with esophagogastric junction cancer decreased due to application of staplers and closure devices as well as gastric conduit technique in recent years, however, it increased slightly at our center since widely using the above devices and gastric conduit techniques from 2009. The objective of this study was to summarize our experiences in the management of anastomotic leakages and analyze the factors affecting leakage healing in the patients with esophagogastric junction cancer after surgical resection in recent 6 years. Methods All patients who received surgical resections for esophagogastric junction cancer and diagnosed anastomotic leak at our center between January 2009 and December 2014 were retrospectively analyzed, we also enrolled the patients who had a longer hospital stay (>30 days) as they may develop anastomotic leak. The binary logistic regression in SPSS 16.0 was applied to analyze the factors that may affect leakage healing. Results Of the 1,815 surgically treated esophagogastric junction cancer patients, 91 cases were diagnosed anastomotic leakage postoperatively. The patients were divided into two groups based on the median leakage healing time (40 days) in this series: fast healing group (37 cases) and slowly healing group (54 cases). All factors that may affect the leakage healing were put into analysis by using binary logistic regression. The results of the analysis showed that leakage size (OR =1.073, P=0.004), thoracic drainage (OR =12.937, P=0.037) and smoking index ≤400 (OR =1.001, P=0.04) significantly affected the healing time, while drinking history (P=0.177), duration of fever after anastomotic leak developed (P=0.084), and hypoproteinemia after leak (P=0.169) also apparently but not significantly affect the healing time. Conclusions Though many factors may affect leakage healing in the esophagogastric junction carcinoma patients, leakage

  19. Wilson Loop Diagrams and Positroids

    NASA Astrophysics Data System (ADS)

    Agarwala, Susama; Marin-Amat, Eloi

    2017-03-01

    In this paper, we study a new application of the positive Grassmannian to Wilson loop diagrams (or MHV diagrams) for scattering amplitudes in N= 4 Super Yang-Mill theory ( N = 4 SYM). There has been much interest in studying this theory via the positive Grassmannians using BCFW recursion. This is the first attempt to study MHV diagrams for planar Wilson loop calculations (or planar amplitudes) in terms of positive Grassmannians. We codify Wilson loop diagrams completely in terms of matroids. This allows us to apply the combinatorial tools in matroid theory used to identify positroids (non-negative Grassmannians) to Wilson loop diagrams. In doing so, we find that certain non-planar Wilson loop diagrams define positive Grassmannians. While non-planar diagrams do not have physical meaning, this finding suggests that they may have value as an algebraic tool, and deserve further investigation.

  20. Loop-bed combustion apparatus

    DOEpatents

    Shang, Jer-Yu; Mei, Joseph S.; Slagle, Frank D.; Notestein, John E.

    1984-01-01

    The present invention is directed to a combustion apparatus in the configuration of a oblong annulus defining a closed loop. Particulate coal together with a sulfur sorbent such as sulfur or dolomite is introduced into the closed loop, ignited, and propelled at a high rate of speed around the loop. Flue gas is withdrawn from a location in the closed loop in close proximity to an area in the loop where centrifugal force imposed upon the larger particulate material maintains these particulates at a location spaced from the flue gas outlet. Only flue gas and smaller particulates resulting from the combustion and innerparticle grinding are discharged from the combustor. This structural arrangement provides increased combustion efficiency due to the essentially complete combustion of the coal particulates as well as increased sulfur absorption due to the innerparticle grinding of the sorbent which provides greater particle surface area.

  1. Higher dimensional loop quantum cosmology

    NASA Astrophysics Data System (ADS)

    Zhang, Xiangdong

    2016-07-01

    Loop quantum cosmology (LQC) is the symmetric sector of loop quantum gravity. In this paper, we generalize the structure of loop quantum cosmology to the theories with arbitrary spacetime dimensions. The isotropic and homogeneous cosmological model in n+1 dimensions is quantized by the loop quantization method. Interestingly, we find that the underlying quantum theories are divided into two qualitatively different sectors according to spacetime dimensions. The effective Hamiltonian and modified dynamical equations of n+1 dimensional LQC are obtained. Moreover, our results indicate that the classical big bang singularity is resolved in arbitrary spacetime dimensions by a quantum bounce. We also briefly discuss the similarities and differences between the n+1 dimensional model and the 3+1 dimensional one. Our model serves as a first example of higher dimensional loop quantum cosmology and offers the possibility to investigate quantum gravity effects in higher dimensional cosmology.

  2. A Generalized Theory of DNA Looping and Cyclization

    NASA Astrophysics Data System (ADS)

    Wilson, David; Lillian, Todd; Perkins, Noel; Tkachenko, Alexei; Meiners, Jens-Christian

    2010-03-01

    We have developed a semi-analytic method for calculating the Stockmayer Jacobson J-factor for protein mediated DNA loops. The formation of DNA loops on the order of a few persistence lengths is a key component in many biological regulatory functions. The binding of LacI protein within the Lac Operon of E.coli serves as the canonical example for loop regulated transcription. We use a non-linear rod model to determine the equilibrium shape of the inter-operator DNA loop under prescribed binding constraints while taking sequence-dependent curvature and elasticity into account. Then we construct a Hamiltonian that describes thermal fluctuations about the open and looped equilibrium states, yielding the entropic and enthalpic costs of loop formation. Our work demonstrates that even for short sequences of the order one persistence length, entropic terms contribute substantially to the J factor. We also show that entropic considerations are able to determine the most favorable binding topology. The J factor can be used to compare the relative loop lifetimes of various DNA sequences, making it a useful tool in sequence design. A corollary of this work is the computation of an effective torsional persistence length, which demonstrates how torsion bending coupling in a constrained geometry affects the conversion of writhe to twist.

  3. Peritonitis due to iatrogenic colpotomy after large loop excision of the transformation zone (LLETZ) in a patient with cervical intraepithelial neoplasia III: our experience of a rare case with review of the literature.

    PubMed

    Varras, M; Akrivis, C; Anastasiadis, A; Lekkas, G; Diakakis, G

    2012-01-01

    A case of peritonitis as an unusual complication of LLETZ (large loop excision of the transformation zone) for the treatment of CIN III associated with unrecognized iatrogenic posterior colpotomy is presented. After the procedure, the patient developed fever 38.3 degrees C and diffused severe pelvic pain. The contributing factors, prevention and management of this complication are discussed. Also, the complications of cold knife cervical conization and LLETZ procedure are reviewed.

  4. Studying DNA Looping by Single-Molecule FRET

    PubMed Central

    Le, Tung T.; Kim, Harold D.

    2014-01-01

    Bending of double-stranded DNA (dsDNA) is associated with many important biological processes such as DNA-protein recognition and DNA packaging into nucleosomes. Thermodynamics of dsDNA bending has been studied by a method called cyclization which relies on DNA ligase to covalently join short sticky ends of a dsDNA. However, ligation efficiency can be affected by many factors that are not related to dsDNA looping such as the DNA structure surrounding the joined sticky ends, and ligase can also affect the apparent looping rate through mechanisms such as nonspecific binding. Here, we show how to measure dsDNA looping kinetics without ligase by detecting transient DNA loop formation by FRET (Fluorescence Resonance Energy Transfer). dsDNA molecules are constructed using a simple PCR-based protocol with a FRET pair and a biotin linker. The looping probability density known as the J factor is extracted from the looping rate and the annealing rate between two disconnected sticky ends. By testing two dsDNAs with different intrinsic curvatures, we show that the J factor is sensitive to the intrinsic shape of the dsDNA. PMID:24998459

  5. The T-loop region of animal mitochondrial tRNA(Ser)(AGY) is a main recognition site for homologous seryl-tRNA synthetase.

    PubMed Central

    Ueda, T; Yotsumoto, Y; Ikeda, K; Watanabe, K

    1992-01-01

    Recognition sites of bovine mitochondrial serine tRNA specific for condons AGY [tRNA(Ser) (AGY)] by the cognate mitochondrial seryl-tRNA synthetase were studied using a range of tRNA(Ser)(AGY) variants which were obtained by the in vitro transcription of synthetic tRNA genes with T7 RNA polymerase. Base replacements in the anticodon and discriminator sites did not affect serine acceptance. However, deletion and/or replacement in the T-loop region completely deprived the variants of their charging activities. Point mutation experiments in this region also showed that the adenosine residue in the middle of the T-loop (position 58), which is involved in tertiary interaction between the T-loop and the truncated D-arm [de Bruijn and Klug, 1983] played a significant role in the recognition process by the synthetase. PMID:1375735

  6. Restriction enzyme cutting site distribution regularity for DNA looping technology.

    PubMed

    Shang, Ying; Zhang, Nan; Zhu, Pengyu; Luo, Yunbo; Huang, Kunlun; Tian, Wenying; Xu, Wentao

    2014-01-25

    The restriction enzyme cutting site distribution regularity and looping conditions were studied systematically. We obtained the restriction enzyme cutting site distributions of 13 commonly used restriction enzymes in 5 model organism genomes through two novel self-compiled software programs. All of the average distances between two adjacent restriction sites fell sharply with increasing statistic intervals, and most fragments were 0-499 bp. A shorter DNA fragment resulted in a lower looping rate, which was also directly proportional to the DNA concentration. When the length was more than 500 bp, the concentration did not affect the looping rate. Therefore, the best known fragment length was longer than 500 bp, and did not contain the restriction enzyme cutting sites which would be used for digestion. In order to make the looping efficiencies reach nearly 100%, 4-5 single cohesive end systems were recommended to digest the genome separately.

  7. A Culture-Behavior-Brain Loop Model of Human Development.

    PubMed

    Han, Shihui; Ma, Yina

    2015-11-01

    Increasing evidence suggests that cultural influences on brain activity are associated with multiple cognitive and affective processes. These findings prompt an integrative framework to account for dynamic interactions between culture, behavior, and the brain. We put forward a culture-behavior-brain (CBB) loop model of human development that proposes that culture shapes the brain by contextualizing behavior, and the brain fits and modifies culture via behavioral influences. Genes provide a fundamental basis for, and interact with, the CBB loop at both individual and population levels. The CBB loop model advances our understanding of the dynamic relationships between culture, behavior, and the brain, which are crucial for human phylogeny and ontogeny. Future brain changes due to cultural influences are discussed based on the CBB loop model.

  8. Modeling loop entropy.

    PubMed

    Chirikjian, Gregory S

    2011-01-01

    Proteins fold from a highly disordered state into a highly ordered one. Traditionally, the folding problem has been stated as one of predicting "the" tertiary structure from sequential information. However, new evidence suggests that the ensemble of unfolded forms may not be as disordered as once believed, and that the native form of many proteins may not be described by a single conformation, but rather an ensemble of its own. Quantifying the relative disorder in the folded and unfolded ensembles as an entropy difference may therefore shed light on the folding process. One issue that clouds discussions of "entropy" is that many different kinds of entropy can be defined: entropy associated with overall translational and rotational Brownian motion, configurational entropy, vibrational entropy, conformational entropy computed in internal or Cartesian coordinates (which can even be different from each other), conformational entropy computed on a lattice, each of the above with different solvation and solvent models, thermodynamic entropy measured experimentally, etc. The focus of this work is the conformational entropy of coil/loop regions in proteins. New mathematical modeling tools for the approximation of changes in conformational entropy during transition from unfolded to folded ensembles are introduced. In particular, models for computing lower and upper bounds on entropy for polymer models of polypeptide coils both with and without end constraints are presented. The methods reviewed here include kinematics (the mathematics of rigid-body motions), classical statistical mechanics, and information theory.

  9. Implementing the CASPiE course-based research experience at the United States Military Academy: Affective responses and effects on critical thinking

    NASA Astrophysics Data System (ADS)

    Chase, Anthony Michael

    The Center for Authentic Science Practices in Education (CASPiE) pioneered a course-based research experience approach to teaching chemistry laboratory courses. The method had previously been studied in a variety of institutional settings. Recently, the United States Military Academy at West Point decided to develop CASPiE-style modules for the introductory honors chemistry course. This research setting presents clean experimental-control comparisons and a group of faculty who were completely new to the method. Equipping students with authentic research experiences early in their education is important regardless of the institution. However, cadets at a military academy must make decisions relatively early (the outset of their second year) as to what their career trajectory will be as eventual officers. In the new CASPiE-based experience, cadets are given the opportunity to select from one of three different modules (analytical chemistry, toxicology, and chemical engineering) in which to participate during the course. These three modules represent subsections of an overall Army waste-to-energy research project. Cadets generate unique hypotheses, real data, and research posters towards the advancement of the project. Posters are then presented in a session. that includes an audience of project stakeholders, course instructors, and other academy faculty and staff. Here, I will present my research methods, evaluative procedures, and findings in the affective domain, critical thinking, and laboratory content comprehension.

  10. Wilson loops in minimal surfaces

    SciTech Connect

    Drukker, Nadav; Gross, David J.; Ooguri, Hirosi

    1999-04-27

    The AdS/CFT correspondence suggests that the Wilson loop of the large N gauge theory with N = 4 supersymmetry in 4 dimensions is described by a minimal surface in AdS{sub 5} x S{sup 5}. The authors examine various aspects of this proposal, comparing gauge theory expectations with computations of minimal surfaces. There is a distinguished class of loops, which the authors call BPS loops, whose expectation values are free from ultra-violet divergence. They formulate the loop equation for such loops. To the extent that they have checked, the minimal surface in AdS{sub 5} x S{sup 5} gives a solution of the equation. The authors also discuss the zig-zag symmetry of the loop operator. In the N = 4 gauge theory, they expect the zig-zag symmetry to hold when the loop does not couple the scalar fields in the supermultiplet. They will show how this is realized for the minimal surface.

  11. Olfactory experience affects the response of meadow voles to the opposite-sex scent donor of mixed-sex over-marks

    PubMed Central

    Ferkin, Michael H.; Ferkin, Daniel A.; Ferkin, Benjamin D.; Vlautin, Christian T.

    2010-01-01

    Scent marking and over-marking are important forms of communication between the sexes for many terrestrial mammals. Over the course of three experiments, we determined whether the amount of time individuals investigate the scent marks of opposite-sex conspecifics is affected by four days of olfactory experience with those conspecifics. In experiment 1, female meadow voles, Microtus pennsylvanicus, spent more time investigating the scent mark of the novel male conspecific than that of the familiar male donor, whereas male voles spent similar amounts of time investigating the scent mark of the familiar female and a novel female conspecific. In experiment 2, voles were exposed to a mixed-sex over-mark in which subjects did not have four days of olfactory experience with either the top-scent donor or the bottom-scent donor. During the test phase, male and female voles spent more time investigating the scent mark of the opposite-sex conspecific that provided the top-scent mark than that of a novel, opposite-sex conspecific. Male and female voles spent similar amounts of time investigating the scent mark of the bottom-scent donor and that of a novel opposite-sex conspecific. In experiment 3, voles were exposed to a mixed-sex over-mark that contained the scent mark of an opposite-sex conspecific with which they had four days of olfactory experience. During the test phase, male voles spent more time investigating the mark of the familiar, top-scent female than the scent mark of a novel female donor but spent similar amounts of time investigating the mark of the familiar, bottom-scent female and that of a novel female donor. In contrast, female voles spent more time investigating the mark of a novel male donor than that of either the familiar, top-scent male or that of the familiar, bottom-scent male. The sex differences in the responses of voles to scent marks and mixed-sex over-marks are discussed in relation to the natural history and non-monogamous mating system of

  12. The Seasonality Of The Loop Current

    NASA Astrophysics Data System (ADS)

    Hall, Cody Alan

    A total of 20 Loop Current eddy separation event dates were derived from Seasat and ERS-1 satellite altimetry, Coastal Zone Color Scanner chlorophyll-a images, Advanced Very High Resolution Radiometer sea surface temperature images, Horizon Marine, Inc. EddyWatch(TM) reports, and Climatology and Simulation of Eddies Eddy Joint Industry Project Gulf Eddy Model analyses spanning mid-1978 - 1992. There were many inconsistencies between the new "pre-altimetry" reanalysis dates derived from mostly non-altimeter data and dates published in past literature based on earlier versions of the pre-altimetry record. The reanalysis dates were derived from a larger compilation of data types and, consequently, were not as affected by intermittent and seasonal data outages common with past records. Therefore, the reanalysis dates are likely more accurate. About 30 Loop Current eddy separation dates were derived from altimetry data spanning 1993 -- 2012. The pre-altimetry and altimetry reanalysis dates along with similar altimetry dates published in other literature exhibit statistically significant seasonality. Eddy separation events are more likely in the months March, August, and September, and less likely in December. Reanalysis event dates were objectively divided into "spring" and "fall" seasons using a k-means clustering algorithm. The estimated spring and fall season centers are March 2nd and August 23 rd, respectively, with seasonal boundaries on May 22nd and December 3rd. The altimetry data suggest that Loop Current intrusion/retreat is dominantly an annual process. Loop Current metrics such as maximum northern boundary latitude and area are relatively high from January through about July and low in September and October. February metrics are statistically different than metrics in either October or November or both. This annual process is primarily driven by and dynamically linked to geostrophic currents seaward of the Campeche Bank shelf break forced by Kelvin waves

  13. Digital phase-locked loop

    NASA Technical Reports Server (NTRS)

    Cliff, R. A. (Inventor)

    1975-01-01

    An digital phase-locked loop is provided for deriving a loop output signal from an accumulator output terminal. A phase detecting exclusive OR gate is fed by the loop digital input and output signals. The output of the phase detector is a bi-level digital signal having a duty cycle indicative of the relative phase of the input and output signals. The accumulator is incremented at a first rate in response to a first output level of the phase detector and at a second rate in response to a second output level of the phase detector.

  14. Open loop distribution system design

    SciTech Connect

    Glamocanin, V. ); Filipovic, V. . Elektrotechnicki fakulet)

    1993-10-01

    The ability to supply consumers of an urban area, with minimum interruption during a feeder segment or substation transformer outage, is assured by a uniform cable size of the feeder segments along the entire loop. Based on the criterion of the uniform cable size, a loop configuration is obtained first by minimizing the installation costs, and then an open loop solution is found by minimizing the power losses. Heuristic rules are proposed and used to obtain an initial solution, as well as to improve current solutions.

  15. Are feedback loops destructive to synchronization?

    NASA Astrophysics Data System (ADS)

    Sheshbolouki, A.; Zarei, M.; Sarbazi-Azad, H.

    2015-08-01

    We study the effects of directionality on synchronization of dynamical networks. Performing the linear stability analysis and the numerical simulation of the Kuramoto model in directed networks, we show that balancing in- and out-degrees of all nodes enhances the synchronization of sparse networks, especially in networks with high clustering coefficient and homogeneous degree distribution. Furthermore, by omitting all the feedback loops, we show that while hierarchical directed acyclic graphs are structurally highly synchronizable, their global synchronization is too sensitive to the choice of natural frequencies and is strongly affected by noise.

  16. Local adaptations to frost in marginal and central populations of the dominant forest tree Fagus sylvatica L. as affected by temperature and extreme drought in common garden experiments.

    PubMed

    Kreyling, Juergen; Buhk, Constanze; Backhaus, Sabrina; Hallinger, Martin; Huber, Gerhard; Huber, Lukas; Jentsch, Anke; Konnert, Monika; Thiel, Daniel; Wilmking, Martin; Beierkuhnlein, Carl

    2014-03-01

    Local adaptations to environmental conditions are of high ecological importance as they determine distribution ranges and likely affect species responses to climate change. Increased environmental stress (warming, extreme drought) due to climate change in combination with decreased genetic mixing due to isolation may lead to stronger local adaptations of geographically marginal than central populations. We experimentally observed local adaptations of three marginal and four central populations of Fagus sylvaticaL., the dominant native forest tree, to frost over winter and in spring (late frost). We determined frost hardiness of buds and roots by the relative electrolyte leakage in two common garden experiments. The experiment at the cold site included a continuous warming treatment; the experiment at the warm site included a preceding summer drought manipulation. In both experiments, we found evidence for local adaptation to frost, with stronger signs of local adaptation in marginal populations. Winter frost killed many of the potted individuals at the cold site, with higher survival in the warming treatment and in those populations originating from colder environments. However, we found no difference in winter frost tolerance of buds among populations, implying that bud survival was not the main cue for mortality. Bud late frost tolerance in April differed between populations at the warm site, mainly because of phenological differences in bud break. Increased spring frost tolerance of plants which had experienced drought stress in the preceding summer could also be explained by shifts in phenology. Stronger local adaptations to climate in geographically marginal than central populations imply the potential for adaptation to climate at range edges. In times of climate change, however, it needs to be tested whether locally adapted populations at range margins can successfully adapt further to changing conditions.

  17. Pre-learning stress differentially affects long-term memory for emotional words, depending on temporal proximity to the learning experience.

    PubMed

    Zoladz, Phillip R; Clark, Brianne; Warnecke, Ashlee; Smith, Lindsay; Tabar, Jennifer; Talbot, Jeffery N

    2011-07-06

    Stress exerts a profound, yet complex, influence on learning and memory and can enhance, impair or have no effect on these processes. Here, we have examined how the administration of stress at different times before learning affects long-term (24-hr) memory for neutral and emotional information. Participants submerged their dominant hand into a bath of ice cold water (Stress) or into a bath of warm water (No stress) for 3 min. Either immediately (Exp. 1) or 30 min (Exp. 2) after the water bath manipulation, participants were presented with a list of 30 words varying in emotional valence. The next day, participants' memory for the word list was assessed via free recall and recognition tests. In both experiments, stressed participants exhibited greater blood pressure, salivary cortisol levels, and subjective pain and stress ratings than non-stressed participants in response to the water bath manipulation. Stress applied immediately prior to learning (Exp. 1) enhanced the recognition of positive words, while stress applied 30 min prior to learning (Exp. 2) impaired free recall of negative words. Participants' recognition of positive words in Experiment 1 was positively associated with their heart rate responses to the water bath manipulation, while participants' free recall of negative words in Experiment 2 was negatively associated with their blood pressure and cortisol responses to the water bath manipulation. These findings indicate that the differential effects of pre-learning stress on long-term memory may depend on the temporal proximity of the stressor to the learning experience and the emotional nature of the to-be-learned information.

  18. Optical loop framing

    SciTech Connect

    Kalibjian, R.; Chong, Y.P.; Prono, D.S.; Cavagnolo, H.R.

    1984-06-01

    The ATA provides an electron beam pulse of 70-ns duration at a 1-Hz rate. Our present optical diagnostics technique involve the imaging of the visible light generated by the beam incident onto the plant of a thin sheet of material. It has already been demonstrated that the light generated has a sufficiently fast temporal reponse in performing beam diagnostics. Notwithstanding possible beam emittance degradation due to scattering in the thin sheet, the observation of beam spatial profiles with relatively high efficiencies has provided data complementary to that obtained from beam wall current monitors and from various x-ray probes and other electrical probes. The optical image sensor consists of a gated, intensified television system. The gate pulse of the image intensifier can be appropriately delayed to give frames that are time-positioned from the head to the tail of the beam with a minimum gate time of 5-ns. The spatial correlation of the time frames from pulse to pulse is very good for a stable electron beam; however, when instabilities do occur, it is difficult to properly assess the spatial composition of the head and the tail of the beam on a pulse-to-pulse basis. Multiple gating within a pulse duration becomes desirable but cannot be performed because the recycle time (20-ms) of the TV system is much longer than the beam pulse. For this reason we have developed an optical-loop framing technique that will allow the recording of two frames within one pulse duration with our present gated/intensified TV system.

  19. Vortex Loops at the Superfluid Lambda Transition: An Exact Theory?

    NASA Technical Reports Server (NTRS)

    Williams, Gary A.

    2003-01-01

    A vortex-loop theory of the superfluid lambda transition has been developed over the last decade, with many results in agreement with experiments. It is a very simple theory, consisting of just three basic equations. When it was first proposed the main uncertainty in the theory was the use Flory scaling to find the fractal dimension of the random-walking vortex loops. Recent developments in high-resolution Monte Carlo simulations have now made it possible to verify the accuracy of this Flory-scaling assumption. Although the loop theory is not yet rigorously proven to be exact, the Monte Carlo results show at the least that it is an extremely good approximation. Recent loop calculations of the critical Casimir effect in helium films in the superfluid phase T < Tc will be compared with similar perturbative RG calculations in the normal phase T > Tc; the two calculations are found to match very nicely right at Tc.

  20. Affective processing requires awareness.

    PubMed

    Lähteenmäki, Mikko; Hyönä, Jukka; Koivisto, Mika; Nummenmaa, Lauri

    2015-04-01

    Studies using backward masked emotional stimuli suggest that affective processing may occur outside visual awareness and imply primacy of affective over semantic processing, yet these experiments have not strictly controlled for the participants' awareness of the stimuli. Here we directly compared the primacy of affective versus semantic categorization of biologically relevant stimuli in 5 experiments (n = 178) using explicit (semantic and affective discrimination; Experiments 1-3) and implicit (semantic and affective priming; Experiments 4-5) measures. The same stimuli were used in semantic and affective tasks. Visual awareness was manipulated by varying exposure duration of the masked stimuli, and subjective level of stimulus awareness was measured after each trial using a 4-point perceptual awareness scale. When participants reported no awareness of the stimuli, semantic and affective categorization were at chance level and priming scores did not differ from zero. When participants were even partially aware of the stimuli, (a) both semantic and affective categorization could be performed above chance level with equal accuracy, (b) semantic categorization was faster than affective categorization, and (c) both semantic and affective priming were observed. Affective categorization speed was linearly dependent on semantic categorization speed, suggesting dependence of affective processing on semantic recognition. Manipulations of affective and semantic categorization tasks revealed a hierarchy of categorization operations beginning with basic-level semantic categorization and ending with superordinate level affective categorization. We conclude that both implicit and explicit affective and semantic categorization is dependent on visual awareness, and that affective recognition follows semantic categorization.

  1. Through the looking glass: an exploratory study of the lived experiences and unmet needs of families affected by Von Hippel-Lindau disease.

    PubMed

    Kasparian, Nadine A; Rutstein, Alison; Sansom-Daly, Ursula M; Mireskandari, Shab; Tyler, Janet; Duffy, Jessica; Tucker, Katherine M

    2015-01-01

    Despite well-established protocols for the medical management of Von Hippel-Lindau disease (VHL), families affected by this rare tumour syndrome continue to face numerous psychological, social, and practical challenges. To our knowledge, this is one of the first qualitative studies to explore the psychosocial difficulties experienced by families affected by VHL. A semi-structured interview was developed to explore patients' and carers' experiences of VHL along several life domains, including: self-identity and self-esteem, interpersonal relationships, education and career opportunities, family communication, physical health and emotional well-being, and supportive care needs. Quantitative measures were also used to examine the prevalence of anxiety, depression, and disease-specific distress in this sample. Participants were recruited via the Hereditary Cancer Clinic at the Prince of Wales Hospital in Sydney, Australia. A total of 23 individual telephone interviews were conducted (15 patients, 8 carers), yielding a response rate of 75%. A diverse range of experiences were reported, including: sustained uncertainty about future tumour development, frustration regarding the need for lifelong medical screening, strained family relationships, difficulties communicating with others about VHL, perceived social isolation and limited career opportunities, financial and care-giving burdens, complex decisions in relation to childbearing, and difficulties accessing expert medical and psychosocial care. Participants also provided examples of psychological growth and resilience, and voiced support for continued efforts to improve supportive care services. More sophisticated systems for connecting VHL patients and their families with holistic, empathic, and person-centred medical and psychosocial care are urgently needed.

  2. VERSATILE TWO-AXIS OPEN-LOOP SOLAR TRACKER CONTROLLER*

    SciTech Connect

    Ward, Christina D; Maxey, L Curt; Evans III, Boyd Mccutchen; Lapsa, Melissa Voss

    2008-01-01

    A versatile single-board controller for two-axis solar tracking applications has been developed and tested on operating solar tracking systems with over two years of field experience. The operating experience gained from the two systems and associated modifications are discussed as representative examples of the practical issues associated with implementing a new two-axis solar tracker design. In this research, open and closed loop control methods were evaluated; however, only the open loop method met the 0.125 tracking accuracy requirement and the requirement to maintain pointing accuracy in hazy and scattered cloudy skies. The open loop algorithm was finally implemented in a microcontroller-based tracking system. Methods of applying this controller hardware to different tracker geometries and hardware are discussed along with the experience gained to date.

  3. The challenging environment on board the International Space Station affects endothelial cell function by triggering oxidative stress through thioredoxin interacting protein overexpression: the ESA-SPHINX experiment.

    PubMed

    Versari, Silvia; Longinotti, Giulia; Barenghi, Livia; Maier, Jeanette Anne Marie; Bradamante, Silvia

    2013-11-01

    Exposure to microgravity generates alterations that are similar to those involved in age-related diseases, such as cardiovascular deconditioning, bone loss, muscle atrophy, and immune response impairment. Endothelial dysfunction is the common denominator. To shed light on the underlying mechanism, we participated in the Progress 40P mission with Spaceflight of Human Umbilical Vein Endothelial Cells (HUVECs): an Integrated Experiment (SPHINX), which consisted of 12 in-flight and 12 ground-based control modules and lasted 10 d. Postflight microarray analysis revealed 1023 significantly modulated genes, the majority of which are involved in cell adhesion, oxidative phosphorylation, stress responses, cell cycle, and apoptosis. Thioredoxin-interacting protein was the most up-regulated (33-fold), heat-shock proteins 70 and 90 the most down-regulated (5.6-fold). Ion channels (TPCN1, KCNG2, KCNJ14, KCNG1, KCNT1, TRPM1, CLCN4, CLCA2), mitochondrial oxidative phosphorylation, and focal adhesion were widely affected. Cytokine detection in the culture media indicated significant increased secretion of interleukin-1α and interleukin-1β. Nitric oxide was found not modulated. Our data suggest that in cultured HUVECs, microgravity affects the same molecular machinery responsible for sensing alterations of flow and generates a prooxidative environment that activates inflammatory responses, alters endothelial behavior, and promotes senescence.

  4. Loop Electrosurgical Excision Procedure (LEEP)

    MedlinePlus

    ... that acts like a scalpel (surgical knife). An electric current is passed through the loop, which cuts away ... A procedure in which an instrument works with electric current to destroy tissue. Local Anesthesia: The use of ...

  5. Integrated optical phase locked loop.

    SciTech Connect

    Lentine, Anthony L.; Kim, Jungwon; Trotter, Douglas Chandler; DeRose, Christopher T.; Kartner, Franz X.; Byun, Hyunil; Nejadmalayeri, Amir H.; Watts, Michael R.; Zortman, William A.

    2010-12-01

    A silicon photonics based integrated optical phase locked loop is utilized to synchronize a 10.2 GHz voltage controlled oscillator with a 509 MHz mode locked laser, achieving 32 fs integrated jitter over 300 kHz bandwidth.

  6. SDO Sees Flourishing Magnetic Loops

    NASA Video Gallery

    A bright set of loops near the edge of the sun’s face grew and shifted quickly after the magnetic field was disrupted by a small eruption on Nov. 25, 2015. Charged particles emitting light in extre...

  7. SDO Sees Brightening Magnetic Loops

    NASA Video Gallery

    Two active regions sprouted arches of bundled magnetic loops in this video from NASA’s Solar Dynamics Observatory taken on Nov. 11-12, 2015. Charged particles spin along the magnetic field, tracing...

  8. Observations of loops and prominences

    NASA Technical Reports Server (NTRS)

    Strong, Keith T.

    1994-01-01

    We review recent observations by the Yohkoh-SXT (Soft X-ray Telescope) in collaboration with other spacecraft and ground-based observatories of coronal loops and prominences. These new results point to problems that SoHO will be able to address. With a unique combination of rapid-cadence digital imaging (greater than or equal to 32 s full-disk and greater than or equal to 2 s partial-frame images), high spatial resolution (greater than or equal to 2.5 arcsec pixels), high sensitivity (EM less than or equal to 10(exp 42) cm(exp -3)), a low-scatter mirror, and large dynamic range, SXT can observe a vast range of targets on the Sun. Over the first 21 months of Yohkoh operations SXT has taken over one million images of the corona and so is building up an invaluable long-term database on the large-scale corona and loop geometry. The most striking thing about the SXT images is the range of loop sizes and shapes. The active regions are a bright tangle of magnetic field lines, surrounded by a network of large-scale quiet-Sun loops stretching over distances in excess of 105 km. The cross-section of most loops seems to be constant. Loops displaying significant Gamma's are the exception, not the rule, implying the presence of widespread currents in the corona. All magnetic structures show changes. Time scales range from seconds to months. The question of how these structures are formed, become filled with hot plasma, and are maintained is still open. While we see the propagation of brightenings along the length of active-region loops and in X-ray jets with velocities of several hundred km/s, much higher velocities are seen in the quiet Sun. In XBP flares, for example, velocities of over 1000 km/s are common. Active-region loops seem to be in constant motion, moving slowly outward, carrying plasma with them. During flares, loops often produce localized brightenings at the base and later at the apex of the loop. Quiescent filaments and prominences have been observed regularly

  9. LETS: An Expressional Loop Notation.

    DTIC Science & Technology

    1982-10-01

    r - ..’ -rI- x- - r ,11 V~ The Expressional Metaphor 2- Waters i "The Expressional Metaphor ’lhe key property of expressions which makes them...development of a notation which has the property of decomposability. Viewing Loops as Expressions Involving Sequences In order to represent loops as...a DEFUNS or LETS. For example, the function EPLIST takes in a discnbodied plist and returns two values: a sequence of the property names. and a

  10. Closed loop spray cooling apparatus

    NASA Technical Reports Server (NTRS)

    Alger, D. L.; Schwab, W. B.; Furman, E. R. (Inventor)

    1979-01-01

    A closed loop apparatus for jet spraying coolant against the back of a radiation target is described. The coolant is circulated through a closed loop with a bubble of inert gas being maintained around the spray. Mesh material is disposed between the bubble and the surface of the liquid coolant which is below the bubble at a predetermined level. In a second arrangement no inert gas is used, the bubble consists of vapor produced when the coolant is sprayed against the target.

  11. High temperature loop heat pipes

    SciTech Connect

    Anderson, W.G.; Bland, J.J.; Fershtater, Y.; Goncharov, K.A.; Nikitkin, M.; Juhasz, A.

    1995-12-31

    Advantages of loop heat pipes over conventional heat pipes include self-priming during start-up, improved tolerance for noncondensible gas, and ability for ground testing in any orientation. The applications for high temperature, alkali-metal working fluid loop heat pipes include space radiators, and bimodal systems. A high temperature loop heat pipe was fabricated and tested at 850 K, using cesium as the working fluid. Previous loop heat pipes were tested with ambient temperature working fluids at temperatures below about 450 K. The loop heat pipe had a titanium envelope, and a titanium aluminide wick. The maximum cesium loop heat pipe power was only about 600 watts, which was lower the predicted 1,000 W power. The power limitation may be due to a wettability problem with the cesium not completely wetting the titanium aluminide wick. This would reduce the pumping capability of the wick, and the maximum power that the heat pipe could carry. This problem could be solved by using a refractory metal powder wick, since the alkali metals are known to wet refractory metal wicks.

  12. THE CORONAL LOOP INVENTORY PROJECT

    SciTech Connect

    Schmelz, J. T.; Pathak, S.; Christian, G. M.; Dhaliwal, R. S. S.; Paul, K. S.

    2015-11-01

    Most coronal physicists now seem to agree that loops are composed of tangled magnetic strands and have both isothermal and multithermal cross-field temperature distributions. As yet, however, there is no information on the relative importance of each of these categories, and we do not know how common one is with respect to the other. In this paper, we investigate these temperature properties for all loop segments visible in the 171-Å image of AR 11294, which was observed by the Atmospheric Imaging Assembly (AIA) on 2011 September 15. Our analysis revealed 19 loop segments, but only 2 of these were clearly isothermal. Six additional segments were effectively isothermal, that is, the plasma emission to which AIA is sensitive could not be distinguished from isothermal emission, within measurement uncertainties. One loop had both isothermal transition region and multithermal coronal solutions. Another five loop segments require multithermal plasma to reproduce the AIA observations. The five remaining loop segments could not be separated reliably from the background in the crucial non-171-Å AIA images required for temperature analysis. We hope that the direction of coronal heating models and the efforts modelers spend on various heating scenarios will be influenced by these results.

  13. Loop Models from SOHO Observations

    NASA Astrophysics Data System (ADS)

    Landini, M.; Brković , A.; Landi, E.; Rüedi, I.; Solanki, S.

    1999-01-01

    The Coronal Diagnostic Spectrometer (CDS) on SOHO is a grazing/normal incidence spectrograph, aimed to produce stigmatic spectra of selected regions of the solar surface in six spectral windows of the extreme ultraviolet from 150 Å to 785 Å (Harrison et al. 1995). In the present work, CDS, EIT, MDI and Yohkoh observations of active region lops have been analyzed. These observations are part of JOP 54. CDS monochromatic images from lines at different temperatures have been co-aligned with EIT and MDI images, and loop structures have been clearly identified using Fe XVI emission lines. Density sensitive lines and lines from adjacent stages of ionization of Fe ions have been used to measure electron density and temperature along the loop length; these measurements have been used to determine the electron pressure along the loop and test the constant pressure assumption commonly used in loop modeling. The observations have been compared with a static, isobaric loop model (Landini and Monsignori Fossi 1975) assuming a temperature-constant heating function in the energy balance equation. Good agreement is found for the temperature distribution along the loop at the coronal level. The model pressure is somewhat higher than obtained from density sensitive line ratios.

  14. Early experience and domestication affect auditory discrimination learning, open field behaviour and brain size in wild Mongolian gerbils and domesticated laboratory gerbils (Meriones unguiculatus forma domestica).

    PubMed

    Stuermer, Ingo W; Wetzel, Wolfram

    2006-10-02

    The influence of early experience and strain differences on auditory discrimination learning, open field behaviour and brain size was investigated in wild-type Mongolian gerbils (strain Ugoe:MU95) raised in the wild (wild F-0) or in the laboratory (wild F-1) and in domesticated Laboratory Gerbils (LAB). Adult males were conditioned for 10 days in a shuttle box go/no-go paradigm to discriminate two frequency-modulated tones. Significant learning was established within 5 days in wild F-0 and within 3 days in wild F-1 and LAB. Spontaneous jumps in the shuttle box (inter-trial crossings) were frequently seen in wild F-0 and F-1, but rarely in LAB. All groups exhibited nearly the same ability to remember after 2 weeks without training. In the open field test applied on 5 consecutive days, no differences in locomotion patterns and inner field preferences were found. Rearing frequency decreased over 5 days in wild gerbils. Running distances (4-6m/min) were similar in wild F-0 and LAB, but higher in wild F-1. The ratio of brain size to body weight did not differ between wild F-0 and F-1, but was 17.1% lower in LAB. Correspondingly high brain weights in wild F-1 and F-0 support our domestication hypothesis and negate any serious effect of early experience or captivity on brain size in Mongolian gerbils. In contrast, wild F-1 raised in the laboratory show a rapid improvement in learning performance, indicating that early experience rather that genetic differences between strains affect shuttle box discrimination learning in gerbils.

  15. The Splitting Loope

    ERIC Educational Resources Information Center

    Wilkins, Jesse L. M.; Norton, Anderson

    2011-01-01

    Teaching experiments have generated several hypotheses concerning the construction of fraction schemes and operations and relationships among them. In particular, researchers have hypothesized that children's construction of splitting operations is crucial to their construction of more advanced fractions concepts (Steffe, 2002). The authors…

  16. Observational constraints on loop quantum cosmology.

    PubMed

    Bojowald, Martin; Calcagni, Gianluca; Tsujikawa, Shinji

    2011-11-18

    In the inflationary scenario of loop quantum cosmology in the presence of inverse-volume corrections, we give analytic formulas for the power spectra of scalar and tensor perturbations convenient to compare with observations. Since inverse-volume corrections can provide strong contributions to the running spectral indices, inclusion of terms higher than the second-order runnings in the power spectra is crucially important. Using the recent data of cosmic microwave background and other cosmological experiments, we place bounds on the quantum corrections.

  17. Protein Loop Closure Using Orientational Restraints from NMR Data

    NASA Astrophysics Data System (ADS)

    Tripathy, Chittaranjan; Zeng, Jianyang; Zhou, Pei; Donald, Bruce Randall

    same data shows that our algorithm is able to achieve higher accuracy: a 3- to 6-fold improvement in backbone RMSD. In addition, computational experiments on synthetic RDC data for a set of protein loops of length 4, 8 and 12 used in previous studies show that, whenever sparse RDCs can be measured, our algorithm can compute longer loops with high accuracy. These results demonstrate that our algorithm can be successfully applied to compute loops with high accuracy from a limited amount of NMR data. Our algorithm will be useful to determine high-quality complete protein backbone conformations, which will benefit the nuclear Overhauser effect (NOE) assignment process in high-resolution protein structure determination.

  18. Direct observation of interstitial dislocation loop coarsening in α-iron.

    PubMed

    Moll, S; Jourdan, T; Lefaix-Jeuland, H

    2013-07-05

    Interstitial loop coarsening by Ostwald ripening can provide insight into single point defects but is very difficult to observe in α-iron and many other metals where nanoscale vacancy clusters dissociate and annihilate loops. We show that by implanting helium in the samples at a carefully chosen energy, it is possible to observe Ostwald ripening of loops by transmission electron microscopy during in situ isochronal annealings. This coarsening of loops results in a sharp increase of the mean loop radius at around 850 K. Using cluster dynamics simulations, we demonstrate that loops evolve due to vacancy emission and that such experiments give a robust estimation of the sum of the formation and migration free energies of vacancies. In particular, our results are in good agreement with self-diffusion experiments and confirm that entropic contributions are large for the vacancy in α-iron.

  19. Three-Loop Radiative-Recoil Corrections to Hyperfine Splitting in Muonium: Diagrams with Polarization Loops

    SciTech Connect

    Eides, Michael I.; Shelyuto, Valery A.

    2009-09-25

    We consider three-loop radiative-recoil corrections to hyperfine splitting in muonium generated by the diagrams with electron and muon vacuum polarizations. We calculate single-logarithmic and nonlogarithmic contributions of order alpha{sup 3}(m/M)E{sub F} generated by gauge invariant sets of diagrams with electron and muon polarization insertions in the electron and muon factors. Combining these corrections with the older results, we obtain total contribution to hyperfine splitting generated by all diagrams with electron and muon polarization loops. The calculation of this contribution completes an important stage in the implementation of the program of reduction of the theoretical uncertainty of hyperfine splitting below 10 Hz. The new results improve the theory of hyperfine splitting and affect the value of the electron-muon mass ratio extracted from experimental data on muonium hyperfine splitting.

  20. Efficiently computing exact geodesic loops within finite steps.

    PubMed

    Xin, Shi-Qing; He, Ying; Fu, Chi-Wing

    2012-06-01

    Closed geodesics, or geodesic loops, are crucial to the study of differential topology and differential geometry. Although the existence and properties of closed geodesics on smooth surfaces have been widely studied in mathematics community, relatively little progress has been made on how to compute them on polygonal surfaces. Most existing algorithms simply consider the mesh as a graph and so the resultant loops are restricted only on mesh edges, which are far from the actual geodesics. This paper is the first to prove the existence and uniqueness of geodesic loop restricted on a closed face sequence; it contributes also with an efficient algorithm to iteratively evolve an initial closed path on a given mesh into an exact geodesic loop within finite steps. Our proposed algorithm takes only an O(k) space complexity and an O(mk) time complexity (experimentally), where m is the number of vertices in the region bounded by the initial loop and the resultant geodesic loop, and k is the average number of edges in the edge sequences that the evolving loop passes through. In contrast to the existing geodesic curvature flow methods which compute an approximate geodesic loop within a predefined threshold, our method is exact and can apply directly to triangular meshes without needing to solve any differential equation with a numerical solver; it can run at interactive speed, e.g., in the order of milliseconds, for a mesh with around 50K vertices, and hence, significantly outperforms existing algorithms. Actually, our algorithm could run at interactive speed even for larger meshes. Besides the complexity of the input mesh, the geometric shape could also affect the number of evolving steps, i.e., the performance. We motivate our algorithm with an interactive shape segmentation example shown later in the paper.

  1. Filter for third order phase locked loops

    NASA Technical Reports Server (NTRS)

    Crow, R. B.; Tausworthe, R. C. (Inventor)

    1973-01-01

    Filters for third-order phase-locked loops are used in receivers to acquire and track carrier signals, particularly signals subject to high doppler-rate changes in frequency. A loop filter with an open-loop transfer function and set of loop constants, setting the damping factor equal to unity are provided.

  2. Kalman Orbit Optimized Loop Tracking

    NASA Technical Reports Server (NTRS)

    Young, Lawrence E.; Meehan, Thomas K.

    2011-01-01

    Under certain conditions of low signal power and/or high noise, there is insufficient signal to noise ratio (SNR) to close tracking loops with individual signals on orbiting Global Navigation Satellite System (GNSS) receivers. In addition, the processing power available from flight computers is not great enough to implement a conventional ultra-tight coupling tracking loop. This work provides a method to track GNSS signals at very low SNR without the penalty of requiring very high processor throughput to calculate the loop parameters. The Kalman Orbit-Optimized Loop (KOOL) tracking approach constitutes a filter with a dynamic model and using the aggregate of information from all tracked GNSS signals to close the tracking loop for each signal. For applications where there is not a good dynamic model, such as very low orbits where atmospheric drag models may not be adequate to achieve the required accuracy, aiding from an IMU (inertial measurement unit) or other sensor will be added. The KOOL approach is based on research JPL has done to allow signal recovery from weak and scintillating signals observed during the use of GPS signals for limb sounding of the Earth s atmosphere. That approach uses the onboard PVT (position, velocity, time) solution to generate predictions for the range, range rate, and acceleration of the low-SNR signal. The low- SNR signal data are captured by a directed open loop. KOOL builds on the previous open loop tracking by including feedback and observable generation from the weak-signal channels so that the MSR receiver will continue to track and provide PVT, range, and Doppler data, even when all channels have low SNR.

  3. Loop gravity: An application and an extension

    NASA Astrophysics Data System (ADS)

    Taveras, Victor Manuel

    In this thesis we address two issues in the area of loop quantum gravity. The first concerns the semiclassical limit in loop quantum cosmology via the use of so-called effective equations. In loop quantum cosmology the quantum dynamics is well understood. We can approximate the full quantum dynamics in the infinite dimensional Hilbert space by projecting it on a finite dimensional submanifold thereof, spanned by suitably chosen semiclassical states. This submanifold is isomorphic with the classical phase space and the projected dynamical flow provides effective equations incorporating the leading quantum corrections to the classical equations of motion. Numerical work has been done in the full theory using quantum states which are semiclassical at late times. These states follow the classical trajectory until the density is on the order of 1% of the Planck density then deviate strongly from the classical trajectory. The effective equations we obtain reproduce this behavior to surprising accuracy. The second issue concerns generalizations of the classical action which is the starting point for loop quantum gravity. In loop quantum gravity one begins with the Einstein-Hilbert action, modified by the addition of the so-called Holst term. Classically, this term does not affect the equations of motion, but it leads to a well-known quantization ambiguity in the quantum theory parametrized by the Barbero-Immirzi parameter, which rescales the eigenvalues of the area and volume operators. We consider the theory obtained by promoting the Barbero-Immirzi parameter to a field. The resulting theory, called Modified Holst Gravity, is equivalent to General Relativity coupled to a pseudo-scalar field. However, this theory turns out to have an unconventional kinetic term for the Barbero-Immirzi field and a rather unnatural coupling with fermions. We then propose a further generalization of the Holst action, which we call Modified Nieh-Yan Gravity, which yields a theory of gravity

  4. Self-sustained hydrodynamic oscillations in a natural-circulation two-phase-flow boiling loop

    NASA Technical Reports Server (NTRS)

    Jain, K. C.

    1969-01-01

    Results of an experimental and theoretical study of factors affecting self-sustaining hydrodynamic oscillations in boiling-water loops are reported. Data on flow variables, and the effects of geometry, subcooling and pressure on the development of oscillatory behavior in a natural-circulation two-phase-flow boiling loop are included.

  5. Study of the open loop and closed loop oscillator techniques

    SciTech Connect

    Baker, Benjamin; Riley, Tony; Langbehn, Adam; Imel, George R.; Benzerga, M. Lamine; Aryal, Harishchandra

    2015-07-01

    This paper presents some aspects of a five year study undertaken at Idaho State University of the measurement of very small worth reactivity samples comparing open and closed loop oscillator techniques. The study conclusively demonstrated the equivalency of the two techniques with regard to uncertainties in reactivity values, i.e., limited by reactor noise. As those results are thoroughly documented in recent publications, in this paper we will concentrate on the support work that was necessary. For example, we describe in some detail the construction and calibration of a pilot rod for the closed loop system. We discuss the campaign to measure the required reactor parameters necessary for inverse-kinetics. Finally, we briefly discuss the transfer of the open loop technique to other reactor systems. (authors)

  6. Lattice calculation of the Polyakov loop and Polyakov loop correlators

    NASA Astrophysics Data System (ADS)

    Weber, Johannes Heinrich

    2017-03-01

    We discuss calculations of the Polyakov loop and of Polyakov loop correlators using lattice gauge theory. We simulate QCD with 2+1 flavors and almost physical quark masses using the highly improved staggered quark action (HISQ).We demonstrate that the entropy derived from the Polyakov loop is a good probe of color screening. In particular, it allows for scheme independent and quantitative conclusions about the deconfinement aspects of the crossover and for a rigorous study of the onset of weak-coupling behavior at high temperatures. We examine the correlators for small and large separations and identify vacuum-like and screening regimes in the thermal medium. We demonstrate that gauge-independent screening properties can be obtained even from gauge-fixed singlet correlators and that we can pin down the asymptotic regime.

  7. Study of the Open Loop and Closed Loop Oscillator Techniques

    SciTech Connect

    Imel, George R.; Baker, Benjamin; Riley, Tony; Langbehn, Adam; Aryal, Harishchandra; Benzerga, M. Lamine

    2015-04-11

    This report presents the progress and completion of a five-year study undertaken at Idaho State University of the measurement of very small worth reactivity samples comparing open and closed loop oscillator techniques.The study conclusively demonstrated the equivalency of the two techniques with regard to uncertainties in reactivity values, i.e., limited by reactor noise. As those results are thoroughly documented in recent publications, in this report we will concentrate on the support work that was necessary. For example, we describe in some detail the construction and calibration of a pilot rod for the closed loop system. We discuss the campaign to measure the required reactor parameters necessary for inverse-kinetics. Finally, we briefly discuss the transfer of the open loop technique to other reactor systems.

  8. Manipulation of ultracold atoms using double-loop microtraps

    NASA Astrophysics Data System (ADS)

    van Wijngaarden, W. A.; Jian, B.; Mouraviev, A.

    2016-05-01

    Ultracold atoms created using microtraps are being used in an increasing number of diverse applications. This paper reviews the double-loop microtrap which consists of two concentric circular wire loops carrying oppositely oriented currents. This generates a magnetic field configuration that traps a magnetic dipole in three-dimensions. The position of the trapped atoms relative to the atom chip surface containing the microwire loops, can be precisely controlled by applying different currents in the two loops or alternatively using a so called bias magnetic field oriented perpendicular to the chip surface. Double-loop microtraps can be daisy chained in series to create a one- or two-dimensional microtrap array. Experiments that have demonstrated a double-loop microtrap array are discussed. Future possibilities are presented as to how atoms can be transferred between adjacent microtraps as well as the use of an additional micro sized Ioffe coil to create a trap having a nonzero magnetic field minimum to reduce atom loss by suppressing Majorana transitions.

  9. Complete maps of molecular-loop conformational spaces.

    PubMed

    Porta, Josep M; Ros, Lluís; Thomas, Federico; Corcho, Francesc; Cantó, Josep; Pérez, Juan Jesús

    2007-10-01

    This paper presents a numerical method to compute all possible conformations of distance-constrained molecular loops, i.e., loops where some interatomic distances are held fixed, while others can vary. The method is general (it can be applied to single or multiple intermingled loops of arbitrary topology) and complete (it isolates all solutions, even if they form positive-dimensional sets). Generality is achieved by reducing the problem to finding all embeddings of a set of points constrained by pairwise distances, which can be formulated as computing the roots of a system of Cayley-Menger determinants. Completeness is achieved by expressing these determinants in Bernstein form and using a numerical algorithm that exploits such form to bound all root locations at any desired precision. The method is readily parallelizable, and the current implementation can be run on single- or multiprocessor machines. Experiments are included that show the method's performance on rigid loops, mobile loops, and multiloop molecules. In all cases, complete maps including all possible conformations are obtained, thus allowing an exhaustive analysis and visualization of all pseudo-rotation paths between different conformations satisfying loop closure.

  10. Benthic metal fluxes and sediment diagenesis in a water reservoir affected by acid mine drainage: A laboratory experiment and reactive transport modeling

    NASA Astrophysics Data System (ADS)

    Torres, E.; Ayora, C.; Jiménez-Arias, J. L.; García-Robledo, E.; Papaspyrou, S.; Corzo, A.

    2014-08-01

    Reservoirs are one of the primary water supply sources. Knowledge of the metal fluxes at the water-sediment interfaces of reservoirs is essential for predicting their ecological quality. Redox oscillations in the water column are promoted by stratification; turnover events may significantly alter metal cycling, especially in reservoirs impacted by acid mine drainage (AMD). To study this phenomenon, an experiment was performed under controlled laboratory conditions. Sediment cores from an AMD-affected reservoir were maintained in a tank with reservoir water for approximately two months and subjected to alternating oxic-hypoxic conditions. A detailed metal speciation in solid phases of the sediment was initially performed by sequential extraction, and pore water was analyzed at the end of each redox period. Tank water metals concentrations were systematically monitored throughout the experiment. The experimental results were then used to calibrate a diffusion-reaction model and quantify the reaction rates and sediment-water fluxes. Under oxic conditions, pH, Fe and As concentrations decreased in the tank due to schwertmannite precipitation, whereas the concentrations of Al, Zn, Cu, Ni, and Co increased due to Al(OH)3 and sulfide dissolution. The reverse trends occurred under hypoxic conditions. Under oxic conditions, the fluxes calculated by applying Fick’s first law to experimental concentration gradients contradicted the fluxes expected based on the evolution of the tank water. According to the reactive transport calculations, this discrepancy can be attributed to the coarse resolution of sediment sampling. The one-cm-thick slices failed to capture effectively the notably narrow (1-2 mm) concentration peaks of several elements in the shallow pore water resulting from sulfide and Al(OH)3 dissolution. The diffusion-reaction model, extended to the complete year, computed that between 25% and 50% of the trace metals and less than 10% of the Al that precipitated under

  11. Loop coupled resonator optical waveguides.

    PubMed

    Song, Junfeng; Luo, Lian-Wee; Luo, Xianshu; Zhou, Haifeng; Tu, Xiaoguang; Jia, Lianxi; Fang, Qing; Lo, Guo-Qiang

    2014-10-06

    We propose a novel coupled resonator optical waveguide (CROW) structure that is made up of a waveguide loop. We theoretically investigate the forbidden band and conduction band conditions in an infinite periodic lattice. We also discuss the reflection- and transmission- spectra, group delay in finite periodic structures. Light has a larger group delay at the band edge in a periodic structure. The flat band pass filter and flat-top group delay can be realized in a non-periodic structure. Scattering matrix method is used to calculate the effects of waveguide loss on the optical characteristics of these structures. We also introduce a tunable coupling loop waveguide to compensate for the fabrication variations since the coupling coefficient of the directional coupler in the loop waveguide is a critical factor in determining the characteristics of a loop CROW. The loop CROW structure is suitable for a wide range of applications such as band pass filters, high Q microcavity, and optical buffers and so on.

  12. Bandwidth controller for phase-locked-loop

    NASA Technical Reports Server (NTRS)

    Brockman, Milton H. (Inventor)

    1992-01-01

    A phase locked loop utilizing digital techniques to control the closed loop bandwidth of the RF carrier phase locked loop in a receiver provides high sensitivity and a wide dynamic range for signal reception. After analog to digital conversion, a digital phase locked loop bandwidth controller provides phase error detection with automatic RF carrier closed loop tracking bandwidth control to accommodate several modes of transmission.

  13. Student investigations of the forces in a roller coaster loop

    NASA Astrophysics Data System (ADS)

    Pendrill, Ann-Marie

    2013-11-01

    How does the experience of a riding in a roller coaster loop depend on your position in the train? This question has been investigated by first year engineering physics students by using multiple representations of force and motion. Theoretical considerations for a circular loop show that the differences between the forces on a rider in the front, middle or back of the train depend on the ratio between train length and radius of the loop, which can be estimated from a photograph. Numerical computations complement the analysis of a video clip, accelerometer data, and measurements of the time needed for the train to move over the highest point. A roller coaster ride gives striking examples of Newton's laws applied to your own body, and demonstrates that the experience depends on the vector character of velocity and acceleration.

  14. Thermal Vacuum Testing of a Helium Loop Heat Pipe for Large Area Cryocooling

    NASA Technical Reports Server (NTRS)

    Ku, Jentung; Robinson, Franklin

    2016-01-01

    A loop heat pipe must start successfully before it can commence its service. The startup transient represents one of the most complex phenomena in the loop heat pipe operation. This paper discusses various aspects of loop heat pipe startup behaviors. Topics include the four startup scenarios, the initial fluid distribution between the evaporator and reservoir that determines the startup scenario, factors that affect the fluid distribution between the evaporator and reservoir, difficulties encountered during the low power startup, and methods to enhance the startup success. Also addressed are the pressure spike and pressure surge during the startup transient, and repeated cycles of loop startup and shutdown under certain conditions.

  15. The aeta - pinatubo loop.

    PubMed

    Marler, Thomas E

    2011-11-01

    The impact of Mount Pinatubo's 1991 eruption on the traditional use of natural resources by the indigenous Aeta was devastating. The damage resulted in the immediate and sustained disconnection of traditional knowledge from the biological resources integral to practice that knowledge. The relatively slow ecosystem recovery a full 20 years after the event hinders the transfer of traditional knowledge to younger generations of Aeta. Their traditional knowledge is at risk of disappearing from the cultural fabric of the Philippines. In seeking to adapt, decisions by the Aeta to accept the development of foreign-designed ecotourism enterprises may negatively affect natural ecosystem recovery. Alternatives to the existing ecotourism practices may be warranted to safeguard Aeta traditional knowledge.

  16. Digital phase-lock loop

    NASA Technical Reports Server (NTRS)

    Thomas, Jr., Jess B. (Inventor)

    1991-01-01

    An improved digital phase lock loop incorporates several distinctive features that attain better performance at high loop gain and better phase accuracy. These features include: phase feedback to a number-controlled oscillator in addition to phase rate; analytical tracking of phase (both integer and fractional cycles); an amplitude-insensitive phase extractor; a more accurate method for extracting measured phase; a method for changing loop gain during a track without loss of lock; and a method for avoiding loss of sampled data during computation delay, while maintaining excellent tracking performance. The advantages of using phase and phase-rate feedback are demonstrated by comparing performance with that of rate-only feedback. Extraction of phase by the method of modeling provides accurate phase measurements even when the number-controlled oscillator phase is discontinuously updated.

  17. Therapygenetics in mindfulness-based cognitive therapy: do genes have an impact on therapy-induced change in real-life positive affective experiences?

    PubMed

    Bakker, J M; Lieverse, R; Menne-Lothmann, C; Viechtbauer, W; Pishva, E; Kenis, G; Geschwind, N; Peeters, F; van Os, J; Wichers, M

    2014-04-22

    Positive affect (PA) has an important role in resilience against depression and has been shown to increase with mindfulness-based cognitive therapy (MBCT). To elucidate the underlying mechanisms of change in PA as well as develop insights that may benefit personalized medicine, the current study examined the contribution of genetic variation to individual differences in change in PA in response to MBCT. Individuals (n=126) with residual depressive symptoms were randomized to either an MBCT group or treatment as usual. PA was assessed using experience sampling methodology (ESM). Single-nucleotide polymorphisms (SNPs) in genes known to be involved in reward functioning were selected. SNPs in the genes for brain-derived neurotrophic factor (BDNF), the muscarinic acetylcholine receptor M2 (CHRM2), the dopamine receptor D4 (DRD4) and the μ1 opioid receptor (OPRM1) significantly moderated the impact of treatment condition over time on PA. Genetic variation in the genes for CHRM2 and OPRM1 specifically had an impact on the level of PA following MBCT. The current study shows that variation in response to MBCT may be contingent on genetic factors associated with the regulation of PA. These findings contribute to our understanding of the processes moderating response to treatment and prediction of treatment outcome.

  18. Many Ways to Loop DNA

    PubMed Central

    Griffith, Jack D.

    2013-01-01

    In the 1960s, I developed methods for directly visualizing DNA and DNA-protein complexes using an electron microscope. This made it possible to examine the shape of DNA and to visualize proteins as they fold and loop DNA. Early applications included the first visualization of true nucleosomes and linkers and the demonstration that repeating tracts of adenines can cause a curvature in DNA. The binding of DNA repair proteins, including p53 and BRCA2, has been visualized at three- and four-way junctions in DNA. The trombone model of DNA replication was directly verified, and the looping of DNA at telomeres was discovered. PMID:24005675

  19. All digital pulsewidth control loop

    NASA Astrophysics Data System (ADS)

    Huang, Hong-Yi; Jan, Shiun-Dian; Pu, Ruei-Iun

    2013-03-01

    This work presents an all-digital pulsewidth control loop (ADPWCL). The proposed system accepts a wide range of input duty cycles and performs a fast correction to the target output pulsewidth. An all-digital delay-locked loop (DLL) with fast locking time using a simplified time to digital converter and a new differential two-step delay element is proposed. The area of the delay element is much smaller than that in conventional designs, while having the same delay range. A test chip is verified in a 0.18-µm CMOS process. The measured duty cycle ranges from 4% to 98% with 7-bit resolution.

  20. Reionization from cosmic string loops

    SciTech Connect

    Olum, Ken D.; Vilenkin, Alexander

    2006-09-15

    Loops formed from a cosmic string network at early times would act as seeds for early formation of halos, which would form galaxies and lead to early reionization. With reasonable guesses about astrophysical and string parameters, the cosmic string scale G{mu} must be no more than about 3x10{sup -8} to avoid conflict with the reionization redshift found by WMAP. The bound is much stronger for superstring models with a small string reconnection probability. For values near the bound, cosmic string loops may explain the discrepancy between the WMAP value and theoretical expectations.

  1. Automated Detection of Solar Loops by the Oriented Connectivity Method

    NASA Technical Reports Server (NTRS)

    Lee, Jong Kwan; Newman, Timothy S.; Gary, G. Allen

    2004-01-01

    An automated technique to segment solar coronal loops from intensity images of the Sun s corona is introduced. It exploits physical characteristics of the solar magnetic field to enable robust extraction from noisy images. The technique is a constructive curve detection approach, constrained by collections of estimates of the magnetic fields orientation. Its effectiveness is evaluated through experiments on synthetic and real coronal images.

  2. Speed-Accuracy Trade-Off in Skilled Typewriting: Decomposing the Contributions of Hierarchical Control Loops

    ERIC Educational Resources Information Center

    Yamaguchi, Motonori; Crump, Matthew J. C.; Logan, Gordon D.

    2013-01-01

    Typing performance involves hierarchically structured control systems: At the higher level, an outer loop generates a word or a series of words to be typed; at the lower level, an inner loop activates the keystrokes comprising the word in parallel and executes them in the correct order. The present experiments examined contributions of the outer-…

  3. Soil microbial biomass and community structure affected by repeated additions of sewage sludge in four Swedish long-term field experiments

    NASA Astrophysics Data System (ADS)

    Börjesson, G.; Kätterer, T.; Kirchmann, H.

    2012-04-01

    Soil organic matter is a key attribute of soil fertility. The pool of soil organic C can be increased, either by mineral fertilisers or by adding organic amendments such as sewage sludge. Sewage sludge has positive effects on agricultural soils through the supply of organic matter and essential plant nutrients, but sludge may also contain unwanted heavy metals, xenobiotic substances and pathogens. One obvious effect of long-term sewage sludge addition is a decrease in soil pH, caused by N mineralisation followed by nitrification, sulphate formation and presence of organic acids with the organic matter added. The objective of this study was to investigate the effect of sewage sludge on the microbial biomass and community structure. Materials and methods We analysed soil samples from four sites where sewage sludge has been repeatedly applied in long-term field experiments situated in different parts of Sweden; Ultuna (59°49'N, 17°39'E, started 1956), Lanna (58°21'N, 13°06'E, started 1997-98), Petersborg (55°32'N, 13°00'E, started 1981) and Igelösa (55°45'N, 13°18'E, started 1981). In these four experiments, at least one sewage sludge treatment is included in the experimental design. In the Ultuna experiment, all organic fertilisers, including sewage sludge, are applied every second year, corresponding to 4 ton C ha-1. The Lanna experiment has a similar design, with 8 ton dry matter ha-1 applied every second year. Lanna also has an additional treatment in which metal salts (Cd, Cu, Ni and Zn) are added together with sewage sludge. At Petersborg and Igelösa, two levels of sewage sludge (4 or 12 ton dry matter ha-1 every 4th year) are compared with three levels of NPK fertiliser (0 N, ½ normal N and normal N). Topsoil samples (0-20 cm depth) from the four sites were analysed for total C, total N, pH and PLFAs (phospholipid fatty acids). In addition, crop yields were recorded. Results At all four sites, sewage sludge has had a positive effect on crop yields

  4. Telomeres thrown for a loop.

    PubMed

    Haber, James E

    2004-11-19

    A remarkable paper from the de Lange lab (Wang et al., 2004) in a recent issue of Cell reveals that homologous recombination can result in the abrupt shortening of telomeres in a process that appears to involve reciprocal crossing over within the t-loop structure that protects chromosome ends.

  5. Ponderomotive Acceleration in Coronal Loops

    NASA Astrophysics Data System (ADS)

    Dahlburg, R. B.; Laming, J. M.; Taylor, B. D.; Obenschain, K.

    2016-11-01

    Ponderomotive acceleration has been asserted to be a cause of the first ionization potential (FIP) effect, the well-known enhancement in abundance by a factor of 3-4 over photospheric values of elements in the solar corona with FIP less than about 10 eV. It is shown here by means of numerical simulations that ponderomotive acceleration occurs in solar coronal loops, with the appropriate magnitude and direction, as a “by-product” of coronal heating. The numerical simulations are performed with the HYPERION code, which solves the fully compressible three-dimensional magnetohydrodynamic equations including nonlinear thermal conduction and optically thin radiation. Numerical simulations of coronal loops with an axial magnetic field from 0.005 to 0.02 T and lengths from 25,000 to 75,000 km are presented. In the simulations the footpoints of the axial loop magnetic field are convected by random, large-scale motions. There is a continuous formation and dissipation of field-aligned current sheets, which act to heat the loop. As a consequence of coronal magnetic reconnection, small-scale, high-speed jets form. The familiar vortex quadrupoles form at reconnection sites. Between the magnetic footpoints and the corona the reconnection flow merges with the boundary flow. It is in this region that the ponderomotive acceleration occurs. Mirroring the character of the coronal reconnection, the ponderomotive acceleration is also found to be intermittent.

  6. A modified PN code tracking loop - Its performance analysis and comparative evaluation

    NASA Astrophysics Data System (ADS)

    Yost, R. A.; Boyd, R. W.

    1982-05-01

    A modified PN code tracking loop (MCTL) has been reported by Yost and Boyd (1980). The MCTL makes it possible to reduce the hardware complexity of a noncoherent delay lock loop in multiple data rate applications. The MCTL utilizes the on-time or data channel as the reference. This concept eliminates the need for the traditional loop's sum channel (early signal plus late signal) and, hence, the hardware associated with that channel. This saving may be substantial if the channel were to be optimized for a number of different data rates. With the elimination of an entire IF channel, the MCTL complexity is nearly equivalent to the dithering loop for PN code tracking considered by Hartmann (1974). However, the MCTL does not suffer the loss in tracking performance (with respect to the traditional loop) that the dithering loop experiences.

  7. MHD Modeling of Coronal Loops: the Transition Region Throat

    NASA Technical Reports Server (NTRS)

    Guarrasi, M.; Reale, F.; Orlando, S.; Mignone, A.; Klimchuk, J. A.

    2014-01-01

    Context. The expansion of coronal loops in the transition region may considerably influence the diagnostics of the plasma emission measure. The cross-sectional area of the loops is expected to depend on the temperature and pressure, and might be sensitive to the heating rate. Aims. The approach here is to study the area response to slow changes in the coronal heating rate, and check the current interpretation in terms of steady heating models. Methods. We study the area response with a time-dependent 2D magnetohydrodynamic (MHD) loop model, including the description of the expanding magnetic field, coronal heating and losses by thermal conduction, and radiation from optically thin plasma. We run a simulation for a loop 50 Mm long and quasi-statically heated to about 4 millikelvin. Results. We find that the area can change substantially with the quasi-steady heating rate, e.g., by approx. 40% at 0.5 millikelvin as the loop temperature varies between 1 millikelvin and 4 millikelvin, and, therefore, affects the interpretation of the differential emission measure vs. temperature (DEM(T)) curves.

  8. Perception as a closed-loop convergence process

    PubMed Central

    Ahissar, Ehud; Assa, Eldad

    2016-01-01

    Perception of external objects involves sensory acquisition via the relevant sensory organs. A widely-accepted assumption is that the sensory organ is the first station in a serial chain of processing circuits leading to an internal circuit in which a percept emerges. This open-loop scheme, in which the interaction between the sensory organ and the environment is not affected by its concurrent downstream neuronal processing, is strongly challenged by behavioral and anatomical data. We present here a hypothesis in which the perception of external objects is a closed-loop dynamical process encompassing loops that integrate the organism and its environment and converging towards organism-environment steady-states. We discuss the consistency of closed-loop perception (CLP) with empirical data and show that it can be synthesized in a robotic setup. Testable predictions are proposed for empirical distinction between open and closed loop schemes of perception. DOI: http://dx.doi.org/10.7554/eLife.12830.001 PMID:27159238

  9. How the Awareness of u-Healthcare Service and Health Conditions Affect Healthy Lifestyle: An Empirical Analysis Based on a u-Healthcare Service Experience

    PubMed Central

    Youm, Sekyoung

    2015-01-01

    Abstract Objective: The objectives of this study are (1) to establish a ubiquitous healthcare (u-healthcare) center for those who wish to use u-healthcare, allowing them to experience the service, and (2) to evaluate the users' awareness and expectations of the service based on their overall assessment. Materials and Methods: To establish the u-healthcare center, a kiosk, devices for health checkup, a body-type examination system, and a physical fitness assessment system were installed. Also, a u-healthcare Web site was developed. A survey was conducted on 280 individuals who visited the u-healthcare center and used the service, to determine (1) individual awareness of u-healthcare before using the service and their change of perception after use, (2) factors that affect the use of u-healthcare, and (3) the effects of disease awareness on exercise habits. Results: Only 25.4% of the participants were aware of u-healthcare, and only 36% who saw the u-healthcare center recognized that it was where the u-healthcare service was provided. The group of individuals who were willing to use the u-healthcare showed statistically significant differences in their satisfaction with the overall environment of the center, as well as the specificity of the descriptions, examination results, kindness of the staff, and their responses. Additionally, the group of individuals who were diagnosed with chronic diseases and the group who were not showed statistically significant differences in the number of days on which they exercised lightly or took a walk. Conclusions: To promote the usage of u-healthcare service, the understanding of the service and the credibility of examination results need to be increased by sharing successful cases. Furthermore, to expand the use of the system that allows a person to regularly check his or her state of health, a lifelong periodical management system linked with another medical welfare program will be needed. PMID:25635473

  10. Can proctoring affect the learning curve of robotic-assisted laparoscopic pyeloplasty? Experience at a high-volume pediatric robotic surgery center.

    PubMed

    Bowen, Diana K; Lindgren, Bruce W; Cheng, Earl Y; Gong, Edward M

    2017-03-01

    We sought to determine if the learning curve in pediatric robotic-assisted laparoscopic pyeloplasty (RALP) for an experienced open surgeon (OS) converting to robotics would be affected by proctoring from an experienced robotic surgeon (RS), and/or the experience of training within the framework of an established robotics program. We reviewed pediatric RALP cases by three surgeons at our institution, including the OS, RS, and a new fellowship-trained surgeon (FTS). We compared the first eight independent RALPs for the OS with the most recent ten RALPs for the RS. As an ancillary analysis, to isolate the impact of proctoring and of a robotics program, we reviewed the first ten cases of the FTS as well the first and last eight cases of the RS at a prior institution. A total of 44 patient charts were reviewed, with a mean follow-up time of 16 months (range 6.7-45 months). Radiologic improvement was seen in all patients with the exception of one who required reoperative pyeloplasty. The FTS, RS, and OS had similar mean operative times; however; when comparing robotic cases at the beginning of each of their learning curves, shorter operative times were achieved by the proctored surgeon (OS). Finally, comparing two RALP cohorts by the RS at his prior institution revealed longer operative times with an inexperienced robotics team. We demonstrate that an experienced open surgeon and fellowship-trained surgeon can quickly attain levels of expertise with pediatric RALP within an established robotic surgical program.

  11. How do soil texture, plant community composition and earthworms affected the infiltration rate in a grassland plant diversity experiment depending on season?

    NASA Astrophysics Data System (ADS)

    Fischer, Christine; Britta, Merkel; Nico, Eisenhauer; Christiane, Roscher; Sabine, Attinger; Stefan, Scheu; Anke, Hildebrandt

    2013-04-01

    Background and aims: In this study we analyzed the influences of plant community characteristics, soil texture and earthworm presence on infiltration rates on a managed grassland plant diversity experiment assessing the role of biotic and abiotic factors on soil hydrology. Methods: We measured infiltration using a hood infiltrometer in subplots with ambient and reduced earthworm density (earthworm extraction) nested in plots of different plant species richness (1, 4, and 16), plant functional group number and composition (1 to 4; legumes, grasses, small herbs, tall herbs) in early summer (June) and autumn (September, October) 2011. Results: The presence of certain plant functional groups such as grasses and legumes influenced infiltration rates and this effect enhanced during the growing season. Infiltration was significantly higher in plots containing legumes than in plots without, and it was significantly lower in the presence of grasses than in their absence. In early summer, earthworm presence and biomass increased the infiltration rates, independently of plant species richness. In October, plant species richness only affected infiltration rates in reduced earthworm plots. At the end of the growing season earthworm populations were negatively influenced by grasses and positively by legumes. In September, infiltration rates were positive related to the proportion of finer grains. The correlation disappears when removing all plots containing legumes from the sample. For all measurements the infiltration rates decreases from early summer to autumn at the matric potentials at pressure zero and -0.02 m, but not for smaller macropores at matric potentials -0.04 and -0.06m. Conclusions: Considering infiltration rates as ecosystem function, this function will largely depend on the ecosystem composition and season, not on biodiversity per se. Our results indicate that biotic factors are of overriding influence for shaping infiltration rates mainly for larger macropores

  12. Development of closed loop roll control for magnetic balance systems

    NASA Technical Reports Server (NTRS)

    Covert, E. E.; Haldeman, C. W.; Ramohalli, G.; Way, P.

    1982-01-01

    This research was undertaken with the goal of demonstrating closed loop control of the roll degree of freedom on the NASA prototype magnetic suspension and balance system at the MIT Aerophysics Laboratory, thus, showing feasibility for a roll control system for any large magnetic balance system which might be built in the future. During the research under this grant, study was directed toward the several areas of torque generation, position sensing, model construction and control system design. These effects were then integrated to produce successful closed loop operation of the analogue roll control system. This experience indicated the desirability of microprocessor control for the angular degrees of freedom.

  13. Theoretical and Experimental Dissection of DNA Loop-Mediated Repression

    NASA Astrophysics Data System (ADS)

    Boedicker, James Q.; Garcia, Hernan G.; Phillips, Rob

    2013-01-01

    Transcriptional networks across all domains of life feature a wide range of regulatory architectures. Theoretical models now make clear predictions about how key parameters describing those architectures modulate gene expression, and the ability to construct genetic circuits with tunable parameters enables precise tests of such models. We dissect gene regulation through DNA looping by tuning network parameters such as repressor copy number, DNA binding strengths, and loop length in both thermodynamic models and experiments. Our results help clarify the short-length mechanical properties of DNA.

  14. A triple helix-loop-helix/basic helix-loop-helix cascade controls cell elongation downstream of multiple hormonal and environmental signaling pathways in Arabidopsis.

    PubMed

    Bai, Ming-Yi; Fan, Min; Oh, Eunkyoo; Wang, Zhi-Yong

    2012-12-01

    Environmental and endogenous signals, including light, temperature, brassinosteroid (BR), and gibberellin (GA), regulate cell elongation largely by influencing the expression of the paclobutrazol-resistant (PRE) family helix-loop-helix (HLH) factors, which promote cell elongation by interacting antagonistically with another HLH factor, IBH1. However, the molecular mechanism by which PREs and IBH1 regulate gene expression has remained unknown. Here, we show that IBH1 interacts with and inhibits a DNA binding basic helix-loop-helix (bHLH) protein, HBI1, in Arabidopsis thaliana. Overexpression of HBI1 increased hypocotyl and petiole elongation, whereas dominant inactivation of HBI1 and its homologs caused a dwarf phenotype, indicating that HBI1 is a positive regulator of cell elongation. In vitro and in vivo experiments showed that HBI1 directly bound to the promoters and activated two EXPANSIN genes encoding cell wall-loosening enzymes; HBI1's DNA binding and transcriptional activities were inhibited by IBH1, but the inhibitory effects of IBH1 were abolished by PRE1. The results indicate that PREs activate the DNA binding bHLH factor HBI1 by sequestering its inhibitor IBH1. Altering each of the three factors affected plant sensitivities to BR, GA, temperature, and light. Our study demonstrates that PREs, IBH1, and HBI1 form a chain of antagonistic switches that regulates cell elongation downstream of multiple external and endogenous signals.

  15. Molecular recognition of 6'-N-5-hexynoate kanamycin A and RNA 1x1 internal loops containing CA mismatches.

    PubMed

    Tran, Tuan; Disney, Matthew D

    2011-02-15

    In our previous study to identify the RNA internal loops that bind an aminoglycoside derivative, we determined that 6'-N-5-hexynoate kanamycin A prefers to bind 1x1 nucleotide internal loops containing C·A mismatches. In this present study, the molecular recognition between a variety of RNAs that are mutated around the C·A loop and the ligand was investigated. Studies show that both loop nucleotides and loop closing pairs affect binding affinity. Most interestingly, it was shown that there is a correlation between the thermodynamic stability of the C·A internal loops and ligand affinity. Specifically, C·A loops that had relatively high or low stability bound the ligand most weakly whereas loops with intermediate stability bound the ligand most tightly. In contrast, there is no correlation between the likelihood that a loop forms a C-A(+) pair at lower pH and ligand affinity. It was also found that a 1x1 nucleotide C·A loop that bound to the ligand with the highest affinity is identical to the consensus site in RNAs that are edited by adenosine deaminases acting on RNA type 2 (ADAR2). These studies provide a detailed investigation of factors affecting small molecule recognition of internal loops containing C·A mismatches, which are present in a variety of RNAs that cause disease.

  16. Using DNA looping to measure sequence dependent DNA elasticity

    NASA Astrophysics Data System (ADS)

    Kandinov, Alan; Raghunathan, Krishnan; Meiners, Jens-Christian

    2012-10-01

    We are using tethered particle motion (TPM) microscopy to observe protein-mediated DNA looping in the lactose repressor system in DNA constructs with varying AT / CG content. We use these data to determine the persistence length of the DNA as a function of its sequence content and compare the data to direct micromechanical measurements with constant-force axial optical tweezers. The data from the TPM experiments show a much smaller sequence effect on the persistence length than the optical tweezers experiments.

  17. Operational Results of a Closed Brayton Cycle Test-Loop

    NASA Astrophysics Data System (ADS)

    Wright, Steven A.; Fuller, Robert; Lipinski, Ronald J.; Nichols, Kenneth; Brown, Nicholas

    2005-02-01

    A number of space and terrestrial power system designs plan to use nuclear reactors that are coupled to Closed-loop Brayton Cycle (CBC) systems to generate electrical power. Because very little experience exists regarding the operational behavior of these systems, Sandia National Laboratories (through its Laboratory Directed Research and Development program) is developing a closed-loop test bed that can be used to determine the operational behavior of these systems and to validate models for these systems. Sandia has contracted Barber-Nichols Corporation to design, fabricate, and assemble a Closed-loop Brayton Cycle (CBC) system. This system was developed by modifying commercially available hardware. It uses a 30 kWe Capstone C-30 gas-turbine unit (www.capstoneturbine.com) with a modified housing that permits the attachment of an electrical heater and a water cooled chiller that are connected to the turbo-machinery in a closed loop. The test-loop reuses the Capstone turbine, compressor, and alternator. The Capstone system's nominal operating point is 1150 K turbine inlet temperature at 96,000 rpm. The annular recuperator and portions of the Capstone control system (inverter) and starter system are also reused. The rotational speed of the turbo-machinery is controlled either by adjusting the alternator load by either using the electrical grid or a separate load bank. This report describes the test-loop hardware SBL-30 (Sandia Brayton Loop-30kWe). Also presented are results of early testing and modeling of the unit. The SBL-30 hardware is currently configured with a heater that is limited to 80 kWth with a maximum outlet temperature of ˜1000 K.

  18. Electrical resistance of complex two-dimensional structures of loops

    NASA Astrophysics Data System (ADS)

    Gomes, M. A. F.; Hora, R. R.; Brito, V. P.

    2011-06-01

    This work presents a study of the dc electrical resistance of a recently discovered hierarchical two-dimensional system which has a complex topology consisting of a distribution of disordered macroscopic loops with no characteristic size and a distribution of several types of contacts between loops. In addition to its intrinsic interest in the important context of low-dimensional systems and crumpled systems, the structures under study are of relevance in a number of areas including soft condensed matter and packing of DNA in viral capsids. In the particular case discussed here, the loops are made of layers of graphite with a height of tens of nanometers deposited on a substrate of cellulose. Experiments with these systems indicate an anomalous electrical resistance of sub-diffusive type. The results reported here are explained with scaling arguments and computer simulation. A comparison with the dc electrical properties of percolation clusters is made, and some other experimental issues as future prospects are commented.

  19. Expansion-loop enclosure resolves subsea line problems

    SciTech Connect

    Rich, S.K.; Alleyne, A.G.

    1998-08-03

    Recent design and construction of a Gulf of Mexico subsea pipeline illustrate the use of buried, enclosed expansion loops to resolve problems from expansion and upheaval buckling. Buried, subsea pipelines operating at high temperatures and pressures experience extreme compressive loads caused by the axial restraint of the soil. The high axial forces combined with imperfections in the seabed may overstress the pipeline or result in upheaval buckling. Typically, expansion loops, or doglegs, are installed to protect the pipeline risers from expansion and to alleviate axial forces. Buried expansion loops, however, are rendered virtually ineffective by the lateral restraint of the soil. Alternative methods to reduce expansion may increase the potential of upheaval buckling or overstressing the pipeline. Therefore, system design must consider expansion and upheaval buckling together. Discussed here are methods of prevention and control of expansion and upheaval buckling, evaluating the impact on the overall system.

  20. Self-contact modeling on beams experiencing loop formation

    NASA Astrophysics Data System (ADS)

    Gay Neto, Alfredo; Pimenta, Paulo M.; Wriggers, Peter

    2015-01-01

    Many engineering scenarios involve contact between beam structures or, eventually, self-contact. Specifically when dealing with a beam submitted to large torsion loads and considering large displacements and rotations, it is possible to occur self-contact. Beams with low bending stiffness loaded with large torsion can present a loop, followed by self-contact and sometimes a snarl formation. This work presents a numerical model and numerical procedures to solve such a kind of self-contact in beams under loop formation. Numerical examples are presented in the context of initially straight nitinol beams. Numerical tests showed that friction may influence loop and snarling formation. Numerical models could predict self-contact occurrence events with good agreement with experimental results already published in literature. Snarling patterns (when occurred) were also predicted correctly, but with delay when compared to experiments. This delay showed to be friction-dependent.

  1. Loop and water effect on stability of intertriplex DNA

    NASA Astrophysics Data System (ADS)

    Yang, Linjing; Lee, Imshik; Wang, Chen; Li, Qing; Bai, Chunli

    1998-02-01

    Stability of four intratriplexes and one intertriplex influenced by loops and water have been investigated by molecular mechanics calculation. The four intratriplexes are 5'-d(TC) 6-d(T) m-d(CT) 6-d(C) n-d(AG) 6-3' ( m, n = 3 or 4), the corresponding intertriplex is d(TC) 6∗d(AG) 6·d(CT) 6 (·, Watson-Crick hydrogen bond; ∗, Hoogsteen hydrogen bond). We studied in detail how loops and water would effect intra- and interstrand interactions of the five triplexes, respectively. The results showed that the existence of loops may have limited impact on the stability of the concerned triplex structures, regardless of water environment. In contrast, water molecules do have appreciable effects on triplex stability. Sugar conformations of the five triplexes were also discussed in this paper. The theoretical results are in good agreement with the FT-IR experiments.

  2. Evolution in a Braided Loop Ensemble

    NASA Video Gallery

    This braided loop has several loops near the 'base' that appear to be unwinding with significant apparent outflow. This is evidence of untwisting, and the braided structure also seeming to unwind w...

  3. Anomalous shape of magnetic loops in the Rayleigh region

    NASA Astrophysics Data System (ADS)

    Seeck, St.; Lambeck, M.

    1995-11-01

    According to its congruency property, the Preisach model demands an equivalent shape of magnetic minor loops, the so-called Rayleigh loops. We measured these loops with an inductive setup and noticed a different anomalous shape of Rayleigh loops which depends on the magnetic history. Special materials (particularly recording media) show a concave-convex shape in contrast to the normal biconvex shape. This anomalous shape can be explained by combining the Preisach model with the Stoner-Wohlfarth model. It follows from this explanation that the degree of the anomaly depends on the material, especially in how far it fulfills the conditions of the Stoner-Wohlfarth model. The experiments show the effect that is expected according to the material. In this way the measurement of the anomalous Rayleigh loops can be used as a new method to test the Stoner-Wohlfarth properties of a material. This is more effective than using the Henkel plot [G. Bertotti and V. Basso, J. Appl. Phys. 73, 5827 (1993)].

  4. Run-time parallelization and scheduling of loops

    NASA Technical Reports Server (NTRS)

    Saltz, Joel H.; Mirchandaney, Ravi; Baxter, Doug

    1988-01-01

    The class of problems that can be effectively compiled by parallelizing compilers is discussed. This is accomplished with the doconsider construct which would allow these compilers to parallelize many problems in which substantial loop-level parallelism is available but cannot be detected by standard compile-time analysis. We describe and experimentally analyze mechanisms used to parallelize the work required for these types of loops. In each of these methods, a new loop structure is produced by modifying the loop to be parallelized. We also present the rules by which these loop transformations may be automated in order that they be included in language compilers. The main application area of the research involves problems in scientific computations and engineering. The workload used in our experiment includes a mixture of real problems as well as synthetically generated inputs. From our extensive tests on the Encore Multimax/320, we have reached the conclusion that for the types of workloads we have investigated, self-execution almost always performs better than pre-scheduling. Further, the improvement in performance that accrues as a result of global topological sorting of indices as opposed to the less expensive local sorting, is not very significant in the case of self-execution.

  5. Mechanism of promoter repression by Lac repressor-DNA loops.

    PubMed

    Becker, Nicole A; Peters, Justin P; Maher, L James; Lionberger, Troy A

    2013-01-07

    The Escherichia coli lactose (lac) operon encodes the first genetic switch to be discovered, and lac remains a paradigm for studying negative and positive control of gene expression. Negative control is believed to involve competition of RNA polymerase and Lac repressor for overlapping binding sites. Contributions to the local Lac repressor concentration come from free repressor and repressor delivered to the operator from remote auxiliary operators by DNA looping. Long-standing questions persist concerning the actual role of DNA looping in the mechanism of promoter repression. Here, we use experiments in living bacteria to resolve four of these questions. We show that the distance dependence of repression enhancement is comparable for upstream and downstream auxiliary operators, confirming the hypothesis that repressor concentration increase is the principal mechanism of repression loops. We find that as few as four turns of DNA can be constrained in a stable loop by Lac repressor. We show that RNA polymerase is not trapped at repressed promoters. Finally, we show that constraining a promoter in a tight DNA loop is sufficient for repression even when promoter and operator do not overlap.

  6. Optimum design of hybrid phase locked loops

    NASA Technical Reports Server (NTRS)

    Lee, P.; Yan, T.

    1981-01-01

    The design procedure of phase locked loops is described in which the analog loop filter is replaced by a digital computer. Specific design curves are given for the step and ramp input changes in phase. It is shown that the designed digital filter depends explicitly on the product of the sampling time and the noise bandwidth of the phase locked loop. This technique of optimization can be applied to the design of digital analog loops for other applications.

  7. Fragmentation of cosmic-string loops

    NASA Technical Reports Server (NTRS)

    York, Thomas

    1989-01-01

    The fragmentation of cosmic string loops is discussed, and the results of a simulation of this process are presented. The simulation can evolve any of a large class of loops essentially exactly, including allowing fragments that collide to join together. Such reconnection enhances the production of small fragments, but not drastically. With or without reconnections, the fragmentation process produces a collection of nonself-intersecting loops whose typical length is on the order of the persistence length of the initial loop.

  8. Data-aided carrier tracking loops

    NASA Technical Reports Server (NTRS)

    Lindsey, W. C.; Simon, M. K.

    1973-01-01

    Power in composite signal sidebands is used to enhance signal-to-noise ratio in carrier tracking loop, thereby reducing radio loss and decreasing probability of receiver error. By adding quadrature channel to phase-lock-loop detector circuit of receiver, dc component can be fed back into carrier tracking loop.

  9. Interaction of dislocations with carbon-decorated dislocation loops in bcc Fe: an atomistic study.

    PubMed

    Terentyev, Dmitry; Anento, Napoleón; Serra, Anna

    2012-11-14

    Properties of ferritic Fe-based alloys are highly sensitive to the carbon content dissolved in the matrix because interstitial carbon is known to strongly interact with lattice point defects and dislocations. As a result, the accumulation of radiation defects and its impact on the change of mechanical properties is also affected by the presence of dissolved interstitial carbon. This work contributes to an understanding of how interstitial carbon atoms influence the properties of small dislocation loops, which form directly in collision cascades upon neutron or ion irradiation and are 'invisible' to (i.e. undetectable by) standard experimental techniques applied to reveal nano-structural damage in metals. We have carried out MD simulations to investigate how the trapping of 1/2 inner product 111 dislocation loops at thermally stable carbon-vacancy complexes, known to form under irradiation, affects the interaction of these dislocation loops with dislocations in bcc Fe. We have considered loops of size 1 and 3.5 nm, which represent experimentally invisible and visible defects, respectively. The obtained results point at the strong suppression of the drag of carbon-decorated loops by dislocations. In the case of direct interaction between dislocation and carbon-decorated loops, invisible loops are found to act as obstacles whose strength is at least twice as high compared to that of undecorated ones. Additional strengthening due to the carbon decoration on the visible loops was also regularly registered. The reasons for the additional strengthening have been rationalized and discussed. It is demonstrated that carbon decoration/segregation at dislocation loops affects not only accumulation of radiation damage under prolonged irradiation but also alters the post-irradiation plastic deformation mechanisms. For the first time, we provide evidence that undetectable dislocation loops decorated by carbon do contribute to the radiation hardening.

  10. Loop connectors in dentogenic diastema

    PubMed Central

    Nayar, Sanjna; Jayesh, Raghevendra; Venkateshwaran; Dinakarsamy, V.

    2015-01-01

    Patients with a missing tooth along with diastema have limited treatment options to restore the edentulous space. The use of a conventional fixed partial denture (FPD) to replace the missing tooth may result in too wide anterior teeth leading to poor esthetics. Loss of anterior teeth with existing diastema may result in excess space available for pontic. This condition presents great esthetic challenge for prosthodontist. If implant supported prosthesis is not possible because of inadequate bone support, FPD along with loop connector may be a treatment option to maintain the diastema and provide optimal esthetic restoration. Here, we report a clinical case where FPD along with loop connector was used to achieve esthetic rehabilitation in maxillary anterior region in which midline diastema has been maintained. PMID:26015732

  11. Microgyroscope with closed loop output

    NASA Technical Reports Server (NTRS)

    Challoner, A. Dorian (Inventor); Gutierrez, Roman C. (Inventor); Tang, Tony K. (Inventor); Cargille, Donald R. (Inventor)

    2002-01-01

    A micro-gyroscope (10) having closed loop operation by a control voltage (V.sub.TY), that is demodulated by an output signal of the sense electrodes (S1, S2), providing Coriolis torque rebalance to prevent displacement of the micro-gyroscope (10) on the output axis (y-axis). The present invention provides wide-band, closed-loop operation for a micro-gyroscope (10) and allows the drive frequency to be closely tuned to a high Q sense axis resonance. A differential sense signal (S1-S2) is compensated and fed back by differentially changing the voltage on the drive electrodes to rebalance Coriolis torque. The feedback signal is demodulated in phase with the drive axis signal (K.sub..omega..crclbar..sub.x) to produce a measure of the Coriolis force.

  12. Loop Variables in String Theory

    NASA Astrophysics Data System (ADS)

    Sathiapalan, B.

    The loop variable approach is a proposal for a gauge-invariant generalization of the sigma-model renormalization group method of obtaining equations of motion in string theory. The basic guiding principle is space-time gauge invariance rather than world sheet properties. In essence it is a version of Wilson's exact renormalization group equation for the world sheet theory. It involves all the massive modes and is defined with a finite world sheet cutoff, which allows one to go off the mass-shell. On shell the tree amplitudes of string theory are reproduced. The equations are gauge-invariant off shell also. This paper is a self-contained discussion of the loop variable approach as well as its connection with the Wilsonian RG.

  13. Some factors affecting the metering of subcooled water with a choked venturi

    SciTech Connect

    Fincke, J.R.; Collins, D.R.

    1981-01-01

    A series of experiments was performed to characterize the subcooled choking process in a convergent-divergent nozzle with a constant-area throat. The experiments were conducted in a low-pressure flow loop capable of a maximum water flow rate of 5.5 L/s with a pressure head of 300 kPa. The pressure and temperature upstream of the nozzle in the flow loop were adjusted between 90 and 300 kPa and 53 and 96/sup 0/C, respectively. The variables measured in this study of critical flow phenomena were the flow rate, upstream pressure and temperature, and the axial wall pressure profiles in the nozzle. Critical mass flow rate data were acquired along five isotherms as a function of stagnation pressure. Factors affecting metering performance are examined.

  14. Loops in inflationary correlation functions

    NASA Astrophysics Data System (ADS)

    Tanaka, Takahiro; Urakawa, Yuko

    2013-12-01

    We review the recent progress regarding the loop corrections to the correlation functions in the inflationary universe. A naive perturbation theory predicts that the loop corrections generated during inflation suffer from various infrared (IR) pathologies. Introducing an IR cutoff by hand is neither satisfactory nor enough to fix the problem of a secular growth, which may ruin the predictive power of inflation models if the inflation lasts sufficiently long. We discuss the origin of the IR divergences and explore the regularity conditions of the loop corrections for the adiabatic perturbation, the iso-curvature perturbation, and the tensor perturbation, in turn. These three kinds of perturbations have qualitative differences, but in discussing the IR regularity there is a feature common to all cases, which is the importance of the proper identification of observable quantities. Genuinely, observable quantities should respect the gauge invariance from the view point of a local observer. Interestingly, we find that the requirement of the IR regularity restricts the allowed quantum states.

  15. Closed-loop active optical system control

    NASA Astrophysics Data System (ADS)

    Sparks, T. E.

    1980-01-01

    A control system, based on a real-time lateral shear interferometer has been developed for use in control during thermal tests and static error compensation experiments. The minicomputer which controls the interferometer and provides its service functions also controls the active system, thereby giving flexibility to the algorithm. The minicomputer system contains 288 K bytes of memory and 15 M bytes of disk storage. The interferometer system employed is composed of the measuring head and its support electronics, a video display on which wavefront contour maps are generated, and a DECwriter operator console. The versatility provided by the use of a general purpose interferometer system allows for interactive control of the closed-loop process. Various arithmetic capabilities such as the addition of wavefronts, division by a constant, and fitting of wavefront data with Zernike polynomials, allow for measurements to be averaged and for removal of alignment errors before correction is performed.

  16. Loran digital phase-locked loop and RF front-end system error analysis

    NASA Technical Reports Server (NTRS)

    Mccall, D. L.

    1979-01-01

    An analysis of the system performance of the digital phase locked loops (DPLL) and RF front end that are implemented in the MINI-L4 Loran receiver is presented. Three of the four experiments deal with the performance of the digital phase locked loops. The other experiment deals with the RF front end and DPLL system error which arise in the front end due to poor signal to noise ratios. The ability of the DPLLs to track the offsets is studied.

  17. Dynamic Aperture-based Solar Loop Segmentation

    NASA Technical Reports Server (NTRS)

    Lee, Jon Kwan; Newman, Timothy S.; Gary, G. Allen

    2006-01-01

    A new method to automatically segment arc-like loop structures from intensity images of the Sun's corona is introduced. The method constructively segments credible loop structures by exploiting the Gaussian-like shape of loop cross-sectional intensity profiles. The experimental results show that the method reasonably segments most of the well-defined loops in coronal images. The method is only the second published automated solar loop segmentation method. Its advantage over the other published method is that it operates independently of supplemental time specific data.

  18. Modeling Phase-Locked Loops Using Verilog

    DTIC Science & Technology

    2007-11-01

    a charge pump, the phase detector has a tri-state output that can drive a opamp loop filter directly. This signal is conditioned by the charge pump...then it can directly drive an opamp based loop filter. Most loop filters are based upon an integrator loop. The integrator loop filter is advantageous...replaced with an accumulator. The opamp circuit can be replaced by a digital filter using Z-transform theory z=exp(jwT), where T is the sampling

  19. Estimation of the current driven by residual loop voltage in LHCD plasma on EAST Tokamak

    NASA Astrophysics Data System (ADS)

    Zhang, X. M.; Yu, L. M.; Wan, B. N.; Xue, E. B.; Fang, Y.; Shi, K. Y.; EAST Team

    2016-02-01

    The lower hybrid wave current drive (LHCD) is one of the efficient methods of driving the non-inductive current required for Tokamak operating in steady-state. Residual loop voltage exists in Tokamak when the non-inductive current is not fully driven. Residual loop voltage also accelerates the fast electrons generated by the lower hybrid wave (LHW), which can drive extra current and combine with the current driven by the LHW. It is generally difficult to separate these two different components of driven current in the experiment. In this paper, the currents driven by LHCD and residual loop voltage are separated directly by solving the Fokker-Plank equation numerically. The fraction of the current driven by residual loop voltage compared to the current driven by LHW is evaluated on the experimental advanced superconducting tokamak (EAST). The current driven by residual loop voltage is several percent of the currents driven by the LHCD when the residual loop voltage is small, but it increases with the residual loop voltage up to 25% when the residual loop voltage is about 2 V. The hot electrical conductivity is deduced from the net current driven by the residual loop voltage. Its distribution profile is related to the fast electron distribution driven by LHW.

  20. SIMULATIONS OF SOLAR JETS CONFINED BY CORONAL LOOPS

    SciTech Connect

    Wyper, P. F.; DeVore, C. R. E-mail: c.richard.devore@nasa.gov

    2016-03-20

    Coronal jets are collimated, dynamic events that occur over a broad range of spatial scales in the solar corona. In the open magnetic field of coronal holes, jets form quasi-radial spires that can extend far out into the heliosphere, while in closed-field regions the jet outflows are confined to the corona. We explore the application of the embedded-bipole model to jets occurring in closed coronal loops. In this model, magnetic free energy is injected slowly by footpoint motions that introduce twist within the closed dome of the jet source region, and is released rapidly by the onset of an ideal kink-like instability. Two length scales characterize the system: the width (N) of the jet source region and the footpoint separation (L) of the coronal loop that envelops the jet source. We find that both the conditions for initiation and the subsequent dynamics are highly sensitive to the ratio L/N. The longest-lasting and most energetic jets occur along long coronal loops with large L/N ratios, and share many of the features of open-field jets, while smaller L/N ratios produce shorter-duration, less energetic jets that are affected by reflections from the far-loop footpoint. We quantify the transition between these behaviors and show that our model replicates key qualitative and quantitative aspects of both quiet Sun and active-region loop jets. We also find that the reconnection between the closed dome and surrounding coronal loop is very extensive: the cumulative reconnected flux at least matches the total flux beneath the dome for small L/N, and is more than double that value for large L/N.