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Sample records for african americans genetic

  1. The Genetic Structure and History of Africans and African Americans

    PubMed Central

    Tishkoff, Sarah A.; Reed, Floyd A.; Friedlaender, Françoise R.; Ehret, Christopher; Ranciaro, Alessia; Froment, Alain; Hirbo, Jibril B.; Awomoyi, Agnes A.; Bodo, Jean-Marie; Doumbo, Ogobara; Ibrahim, Muntaser; Juma, Abdalla T.; Kotze, Maritha J.; Lema, Godfrey; Moore, Jason H.; Mortensen, Holly; Nyambo, Thomas B.; Omar, Sabah A.; Powell, Kweli; Pretorius, Gideon S.; Smith, Michael W.; Thera, Mahamadou A.; Wambebe, Charles; Weber, James L.; Williams, Scott M.

    2010-01-01

    Africa is the source of all modern humans, but characterization of genetic variation and of relationships among populations across the continent has been enigmatic. We studied 121 African populations, four African American populations, and 60 non-African populations for patterns of variation at 1327 nuclear microsatellite and insertion/deletion markers. We identified 14 ancestral population clusters in Africa that correlate with self-described ethnicity and shared cultural and/or linguistic properties. We observed high levels of mixed ancestry in most populations, reflecting historical migration events across the continent. Our data also provide evidence for shared ancestry among geographically diverse hunter-gatherer populations (Khoesan speakers and Pygmies). The ancestry of African Americans is predominantly from Niger-Kordofanian (~71%), European (~13%), and other African (~8%) populations, although admixture levels varied considerably among individuals. This study helps tease apart the complex evolutionary history of Africans and African Americans, aiding both anthropological and genetic epidemiologic studies. PMID:19407144

  2. Genetic bottlenecks, perceived racism, and hypertension risk among African Americans and first-generation African immigrants.

    PubMed

    Poston, W S; Pavlik, V N; Hyman, D J; Ogbonnaya, K; Hanis, C L; Haddock, C K; Hyder, M L; Foreyt, J P

    2001-05-01

    The complexity of factors influencing the development of hypertension (HTN) in African Americans has given rise to theories suggesting that genetic changes occurred due to selection pressures/genetic bottleneck effects (ie, constriction of existing genetic variability) over the course of the slave trade. Ninety-nine US-born and 86 African-born health professionals were compared in a cross-sectional survey examining genetic and psychosocial predictors of HTN. We examined the distributions of three genetic loci (G-protein, AGT-235, and ACE I/D) that have been associated with increased HTN risk. There were no significant differences between US-born African Americans and African-born immigrants in the studied genetic loci or biological variables (eg, plasma renin and angiotensin converting enzyme activity), except that the AGT-235 homozygous T genotype was somewhat more frequent among African-born participants than US-born African Americans. Only age, body mass index, and birthplace consistently demonstrated associations with HTN status. Thus, there was no evidence of a genetic bottleneck in the loci studied, ie, that US-born African Americans have different genotype distributions that increase their risk for HTN. In fact, some of the genotypic distributions evidenced lower frequencies of HTN-related alleles among US-born African Americans, providing evidence of European admixture. The consistent finding that birthplace (ie, US vs Africa) was associated with HTN, even though it was not always significant, suggests potential and unmeasured cultural, lifestyle, and environmental differences between African immigrants and US-born African Americans that are protective against HTN.

  3. Donation Intentions for Cancer Genetics Research Among African Americans

    PubMed Central

    McDonald, Jasmine A.; Weathers, Benita; Barg, Frances K.; Troxel, Andrea B.; Shea, Judy A.; Bowen, Deborah; Guerra, Carmen E.

    2012-01-01

    Aims: Scientific agencies rely on individuals to donate their DNA to support research on chronic conditions that disproportionately affect African Americans; however, donation is variable in this population. The purpose of this study was to identify sociodemographic characteristics, health care variables, and cultural values having significant independent associations with intentions to donate blood or saliva samples for cancer genetics research among African American adults. Method: Cross-sectional survey of donation intentions. Results: The majority of respondents (73%) were willing to donate a biological sample for cancer genetics research. The results of the multivariate regression model found that respondents who received care at a facility other than a doctor's office (e.g., community center) were about five times more likely to be willing to donate a sample for cancer genetics research (odds ratio [OR]=5.28, 95% confidence interval [CI]=1.16–24.12, p=0.03); whereas, greater levels of religiosity (OR=0.09, 95% CI=0.01–0.75, p=0.02) and present temporal orientation (OR=0.23, 95% CI=0.06–0.79, p=0.02) were associated with a lower likelihood of donating a sample. Conclusion: Efforts to enhance donation of biological samples for cancer genetics research may need to target diverse clinical sites for recruitment. Additionally, recruitment materials may need to address cultural values related to religiosity and present temporal orientation. PMID:22224593

  4. African Genetic Ancestry is Associated with Sleep Depth in Older African Americans

    PubMed Central

    Halder, Indrani; Matthews, Karen A.; Buysse, Daniel J.; Strollo, Patrick J.; Causer, Victoria; Reis, Steven E.; Hall, Martica H.

    2015-01-01

    Study Objectives: The mechanisms that underlie differences in sleep characteristics between European Americans (EA) and African Americans (AA) are not fully known. Although social and psychological processes that differ by race are possible mediators, the substantial heritability of sleep characteristics also suggests genetic underpinnings of race differences. We hypothesized that racial differences in sleep phenotypes would show an association with objectively measured individual genetic ancestry in AAs. Design: Cross sectional. Setting: Community-based study. Participants: Seventy AA adults (mean age 59.5 ± 6.7 y; 62% female) and 101 EAs (mean age 60.5 ± 7 y, 39% female). Measurements and Results: Multivariate tests were used to compare the Pittsburgh Sleep Quality Index (PSQI) and in-home polysomnographic measures of sleep duration, sleep efficiency, apnea-hypopnea index (AHI), and indices of sleep depth including percent visually scored slow wave sleep (SWS) and delta EEG power of EAs and AAs. Sleep duration, efficiency, and sleep depth differed significantly by race. Individual % African ancestry (%AF) was measured in AA subjects using a panel of 1698 ancestry informative genetic markers and ranged from 10% to 88% (mean 67%). Hierarchical linear regression showed that higher %AF was associated with lower percent SWS in AAs (β (standard error) = −4.6 (1.5); P = 0.002), and explained 11% of the variation in SWS after covariate adjustment. A similar association was observed for delta power. No association was observed for sleep duration and efficiency. Conclusion: African genetic ancestry is associated with indices of sleep depth in African Americans. Such an association suggests that part of the racial differences in slow-wave sleep may have genetic underpinnings. Citation: Halder I, Matthews KA, Buysse DJ, Strollo PJ, Causer V, Reis SE, Hall MH. African genetic ancestry is associated with sleep depth in older African Americans. SLEEP 2015;38(8):1185–1193

  5. Inclusion of African Americans in genetic studies: what is the barrier?

    PubMed

    Hartz, Sarah M; Johnson, Eric O; Saccone, Nancy L; Hatsukami, Dorothy; Breslau, Naomi; Bierut, Laura J

    2011-08-01

    To facilitate an increase in the amount of data on minority subjects collected for genetic databases, the authors attempted to clarify barriers to African-American participation in genetic studies. They randomly sampled 78,072 subjects from the community (Missouri Family Registry, 2002-2007). Of these, 28,658 participated in a telephone screening interview, 3,179 were eligible to participate in the genetic study, and 1,919 participated in the genetic study. Response rates were examined in relation to the proportion of subjects in the area who were African-American according to US Census 2000 zip code demographic data. Compared with zip codes with fewer than 5% African Americans (average = 2% African-American), zip codes with at least 60% African Americans (average = 87% African-American) had higher proportions of subjects with an incorrect address or telephone number but lower proportions of subjects who did not answer the telephone and subjects who refused the telephone interview (P < 0.0001). Based on reported race from the telephone screening, 71% of eligible African Americans and 57% of eligible European Americans participated in the genetic study (P < 0.0001). The results of this study suggest that increasing the number of African Americans in genetic databases may be achieved by increasing efforts to locate and contact them.

  6. Novel genetic predictors of venous thromboembolism risk in African Americans

    PubMed Central

    Hernandez, Wenndy; Gamazon, Eric R.; Smithberger, Erin; O’Brien, Travis J.; Harralson, Arthur F.; Tuck, Matthew; Barbour, April; Kittles, Rick A.; Cavallari, Larisa H.

    2016-01-01

    Venous thromboembolism (VTE) is the third most common life-threatening cardiovascular condition in the United States, with African Americans (AAs) having a 30% to 60% higher incidence compared with other ethnicities. The mechanisms underlying population differences in the risk of VTE are poorly understood. We conducted the first genome-wide association study in AAs, comprising 578 subjects, followed by replication of highly significant findings in an independent cohort of 159 AA subjects. Logistic regression was used to estimate the association between genetic variants and VTE risk. Through bioinformatics analysis of the top signals, we identified expression quantitative trait loci (eQTLs) in whole blood and investigated the messenger RNA expression differences in VTE cases and controls. We identified and replicated single-nucleotide polymorphisms on chromosome 20 (rs2144940, rs2567617, and rs1998081) that increased risk of VTE by 2.3-fold (P < 6 × 10−7). These risk variants were found in higher frequency among populations of African descent (>20%) compared with other ethnic groups (<10%). We demonstrate that SNPs on chromosome 20 are cis-eQTLs for thrombomodulin (THBD), and the expression of THBD is lower among VTE cases compared with controls (P = 9.87 × 10−6). We have identified novel polymorphisms associated with increased risk of VTE in AAs. These polymorphisms are predominantly found among populations of African descent and are associated with THBD gene expression. Our findings provide new molecular insight into a mechanism regulating VTE susceptibility and identify common genetic variants that increase the risk of VTE in AAs, a population disproportionately affected by this disease. PMID:26888256

  7. A review of genetics, arterial stiffness, and blood pressure in African Americans.

    PubMed

    Hall, Jennifer L; Duprez, Daniel A; Barac, Ana; Rich, Stephen S

    2012-06-01

    The prevalence of hypertension in African Americans in the USA is among the highest in the world and increasing. The identification of genes and pathways regulating blood pressure in African Americans has been challenging. An early predictor of hypertension is arterial stiffness. The prevalence of arterial stiffness is significantly higher in African Americans compared to Caucasians. Approximately 20 % of the variance in arterial stiffness is estimated to be heritable. Identifying genes and biological pathways regulating arterial stiffness may provide insight into the genetics underlying the increased risk of hypertension in African Americans. This paper reviews the genetic findings to date in the area of arterial stiffness and blood pressure in African Americans with an emphasis on the current limitations and new efforts to move the field forward.

  8. The Genetic Ancestry of African Americans, Latinos, and European Americans across the United States

    PubMed Central

    Bryc, Katarzyna; Durand, Eric Y.; Macpherson, J. Michael; Reich, David; Mountain, Joanna L.

    2015-01-01

    Over the past 500 years, North America has been the site of ongoing mixing of Native Americans, European settlers, and Africans (brought largely by the trans-Atlantic slave trade), shaping the early history of what became the United States. We studied the genetic ancestry of 5,269 self-described African Americans, 8,663 Latinos, and 148,789 European Americans who are 23andMe customers and show that the legacy of these historical interactions is visible in the genetic ancestry of present-day Americans. We document pervasive mixed ancestry and asymmetrical male and female ancestry contributions in all groups studied. We show that regional ancestry differences reflect historical events, such as early Spanish colonization, waves of immigration from many regions of Europe, and forced relocation of Native Americans within the US. This study sheds light on the fine-scale differences in ancestry within and across the United States and informs our understanding of the relationship between racial and ethnic identities and genetic ancestry. PMID:25529636

  9. The genetic ancestry of African Americans, Latinos, and European Americans across the United States.

    PubMed

    Bryc, Katarzyna; Durand, Eric Y; Macpherson, J Michael; Reich, David; Mountain, Joanna L

    2015-01-01

    Over the past 500 years, North America has been the site of ongoing mixing of Native Americans, European settlers, and Africans (brought largely by the trans-Atlantic slave trade), shaping the early history of what became the United States. We studied the genetic ancestry of 5,269 self-described African Americans, 8,663 Latinos, and 148,789 European Americans who are 23andMe customers and show that the legacy of these historical interactions is visible in the genetic ancestry of present-day Americans. We document pervasive mixed ancestry and asymmetrical male and female ancestry contributions in all groups studied. We show that regional ancestry differences reflect historical events, such as early Spanish colonization, waves of immigration from many regions of Europe, and forced relocation of Native Americans within the US. This study sheds light on the fine-scale differences in ancestry within and across the United States and informs our understanding of the relationship between racial and ethnic identities and genetic ancestry.

  10. The genetic ancestry of African Americans, Latinos, and European Americans across the United States.

    PubMed

    Bryc, Katarzyna; Durand, Eric Y; Macpherson, J Michael; Reich, David; Mountain, Joanna L

    2015-01-01

    Over the past 500 years, North America has been the site of ongoing mixing of Native Americans, European settlers, and Africans (brought largely by the trans-Atlantic slave trade), shaping the early history of what became the United States. We studied the genetic ancestry of 5,269 self-described African Americans, 8,663 Latinos, and 148,789 European Americans who are 23andMe customers and show that the legacy of these historical interactions is visible in the genetic ancestry of present-day Americans. We document pervasive mixed ancestry and asymmetrical male and female ancestry contributions in all groups studied. We show that regional ancestry differences reflect historical events, such as early Spanish colonization, waves of immigration from many regions of Europe, and forced relocation of Native Americans within the US. This study sheds light on the fine-scale differences in ancestry within and across the United States and informs our understanding of the relationship between racial and ethnic identities and genetic ancestry. PMID:25529636

  11. Impact of malaria on genetic polymorphism and genetic diseases in Africans and African Americans.

    PubMed Central

    Miller, L H

    1994-01-01

    The high mortality from malaria in sub-Sahara Africa selected multiple genes that give the population a selective advantage. Identification of the genetic basis for resistance may suggest unusual approaches to development of malarial vaccines and antimalarial drugs. Some of these genes may be deleterious, although of selective advantage within the African setting, and need to be identified for counseling for disease prevention. PMID:8146132

  12. African American Women’s Limited Knowledge and Experiences with Genetic Counseling for Hereditary Breast Cancer

    PubMed Central

    Sheppard, Vanessa B.; Graves, Kristi D.; Christopher, Juleen; Hurtado-de-Mendoza, Alejandra; Talley, Costellia; Williams, Karen Patricia

    2014-01-01

    Genetic counseling and testing for hereditary breast cancer have the potential benefit of early detection and early interventions in African American women. However, African American women have low use of these services compared to White women. We conducted two focus groups with African American women diagnosed with breast cancer (affected group, n=13) and women with at least one first-degree relative with breast/ovarian cancer (unaffected group, n= 8). A content analysis approach was employed to analyze interview data. Breast cancer survivors had more knowledge about genetic counseling and testing than participants who were unaffected with cancer. However, knowledge about genetic counseling was limited in both groups. Barriers to pursuing genetic counseling and testing included poor understanding of the genetic counseling and testing process, fear of carrying the mutation, concerns about discrimination, and cost. Motivators to participate in genetic counseling and testing included desire to help family members, insurance coverage, and potential of benefiting the larger African American community. Education efforts are needed to increase genetic counseling and testing awareness in the African American community. PMID:24186304

  13. African American women's limited knowledge and experiences with genetic counseling for hereditary breast cancer.

    PubMed

    Sheppard, Vanessa B; Graves, Kristi D; Christopher, Juleen; Hurtado-de-Mendoza, Alejandra; Talley, Costellia; Williams, Karen Patricia

    2014-06-01

    Genetic counseling and testing for hereditary breast cancer have the potential benefit of early detection and early interventions in African American women. However, African American women have low use of these services compared to White women. We conducted two focus groups with African American women diagnosed with breast cancer (affected group, n = 13) and women with at least one first-degree relative with breast/ovarian cancer (unaffected group, n = 8). A content analysis approach was employed to analyze interview data. Breast cancer survivors had more knowledge about genetic counseling and testing than participants who were unaffected with cancer. However, knowledge about genetic counseling was limited in both groups. Barriers to pursuing genetic counseling and testing included poor understanding of the genetic counseling and testing process, fear of carrying the mutation, concerns about discrimination, and cost. Motivators to participate in genetic counseling and testing included desire to help family members, insurance coverage, and potential of benefiting the larger African American community. Education efforts are needed to increase genetic counseling and testing awareness in the African American community.

  14. A Comprehensive Genetic Association Study of Alzheimer Disease in African Americans

    PubMed Central

    Logue, Mark W.; Schu, Matthew; Vardarajan, Badri N.; Buros, Jacki; Green, Robert C.; Go, Rodney C. P.; Griffith, Patrick; Obisesan, Thomas O.; Shatz, Rhonna; Borenstein, Amy; Cupples, L. Adrienne; Lunetta, Kathryn L.; Fallin, M. Daniele; Baldwin, Clinton T.; Farrer, Lindsay A.

    2012-01-01

    Objectives To evaluate the association of genetic variation with late-onset Alzheimer disease (AD) in African Americans, including genes implicated in recent genome-wide association studies of whites. Design We analyzed a genome-wide set of 2.5 million imputed markers to evaluate the genetic basis of AD in an African American population. Subjects Five hundred thirteen well-characterized African American AD cases and 496 cognitively normal African American control subjects. Setting Data were collected from multiple sites as part of the Multi-Institutional Research on Alzheimer Genetic Epidemiology (MIRAGE) Study and the Henry Ford Health System as part of the Genetic and Environmental Risk Factors for Alzheimer Disease Among African Americans (GenerAAtions) Study. Results Several significant single-nucleotide polymorphisms (SNPs) were observed in the region of the apolipoprotein E gene (APOE). After adjusting for the confounding effects of APOE genotype, one of these SNPs, rs6859 in PVRL2, remained significantly associated with AD (P=.0087). Association was also observed with SNPs in CLU, PICALM, BIN1, EPHA1, MS4A, ABCA7, and CD33, although the effect direction for some SNPs and the most significant SNPs differed from findings in data sets consisting of whites. Finally, using the African American genome-wide association study data set as a discovery sample, we obtained suggestive evidence of association with SNPs for several novel candidate genes. Conclusions Some genes contribute to AD pathogenesis in both white and African American cohorts, although it is unclear whether the causal variants are the same. A larger African American sample will be needed to confirm novel gene associations, which may be population specific. PMID:22159054

  15. African American Health

    MedlinePlus

    ... specific health concerns. Differences in the health of groups can result from Genetics Environmental factors Access to care Cultural factors On this page, you'll find links to health issues that affect African Americans.

  16. African Ancestry Analysis and Admixture Genetic Mapping for Proliferative Diabetic Retinopathy in African Americans

    PubMed Central

    Tandon, Arti; Chen, Ching J.; Penman, Alan; Hancock, Heather; James, Maurice; Husain, Deeba; Andreoli, Christopher; Li, Xiaohui; Kuo, Jane Z.; Idowu, Omolola; Riche, Daniel; Papavasilieou, Evangelia; Brauner, Stacey; Smith, Sataria O.; Hoadley, Suzanne; Richardson, Cole; Kieser, Troy; Vazquez, Vanessa; Chi, Cheryl; Fernandez, Marlene; Harden, Maegan; Cotch, Mary Frances; Siscovick, David; Taylor, Herman A.; Wilson, James G.; Reich, David; Wong, Tien Y.; Klein, Ronald; Klein, Barbara E. K.; Rotter, Jerome I.; Patterson, Nick; Sobrin, Lucia

    2015-01-01

    Purpose. To examine the relationship between proportion of African ancestry (PAA) and proliferative diabetic retinopathy (PDR) and to identify genetic loci associated with PDR using admixture mapping in African Americans with type 2 diabetes (T2D). Methods. Between 1993 and 2013, 1440 participants enrolled in four different studies had fundus photographs graded using the Early Treatment Diabetic Retinopathy Study scale. Cases (n = 305) had PDR while controls (n = 1135) had nonproliferative diabetic retinopathy (DR) or no DR. Covariates included diabetes duration, hemoglobin A1C, systolic blood pressure, income, and education. Genotyping was performed on the Affymetrix platform. The association between PAA and PDR was evaluated using logistic regression. Genome-wide admixture scanning was performed using ANCESTRYMAP software. Results. In the univariate analysis, PDR was associated with increased PAA (odds ratio [OR] = 1.36, 95% confidence interval [CI] = 1.16–1.59, P = 0.0002). In multivariate regression adjusting for traditional DR risk factors, income and education, the association between PAA and PDR was attenuated and no longer significant (OR = 1.21, 95% CI = 0.59–2.47, P = 0.61). For the admixture analyses, the maximum genome-wide score was 1.44 on chromosome 1. Conclusions. In this largest study of PDR in African Americans with T2D to date, an association between PAA and PDR is not present after adjustment for clinical, demographic, and socioeconomic factors. No genome-wide significant locus (defined as having a locus-genome statistic > 5) was identified with admixture analysis. Further analyses with even larger sample sizes are needed to definitively assess if any admixture signal for DR is present. PMID:26098467

  17. Diabetes in African Americans

    PubMed Central

    Marshall, M

    2005-01-01

    African Americans have a high risk for type 2 diabetes. Genetic traits, the prevalence of obesity, and insulin resistance all contribute to the risk of diabetes in the African American community. African Americans have a high rate of diabetic complications, because of poor glycaemic control and racial disparities in health care in the USA. African Americans with diabetes may have an atypical presentation that simulates type 1 diabetes, but then their subsequent clinical course is typical of type 2 diabetes. Culturally sensitive strategies, structured disease management protocols, and the assistance of nurses, diabetic educators, and other health care professionals are effective in improving the outcome of diabetes in the African American community. PMID:16344294

  18. Knowledge, beliefs and practices of African-American nurses regarding genetics/genomics.

    PubMed

    Spruill, Ida; Coleman, Bernice; Collins-McNeil, Janice

    2009-12-01

    In an effort to increase the awareness of genetics among African-American nurses, a pilot study was conducted with members of the National Black Nurses Association (NBNA) in order to assess the interest, knowledge, and practice of African-American nurses regarding genetics and to identify program needs. Self-administered surveys were distributed to a convenience sample of 77 African-American nurses (N=77) attending the 2006 Annual Conference of the National Black Nurses Association (NBNA) in Hollywood, Florida. Measures of central tendency and frequencies were used to analyze the data. Over half the sample (56%) self-reported their knowledge of genetics as being only fair or poor; however, 56% were interested in genetic awareness training, and 93.5% were willing to participate in planned genomic education. An unexpected finding was that 77.9% believed that genetic tests could be used to discriminate against minorities. Although this sample reported limited genetics/genomic knowledge, their interest in genetics training and the incorporation of genetics into daily practice was high. These data can be used to support the development and implementation of culturally appropriate genetic awareness training. Challenges for the organization include identification of the type of venue to use for genetic/genomic awareness training and identification of resources and partnerships to support NBNA members in gaining genetic awareness training.

  19. Knowledge, beliefs and practices of African-American nurses regarding genetics/genomics.

    PubMed

    Spruill, Ida; Coleman, Bernice; Collins-McNeil, Janice

    2009-12-01

    In an effort to increase the awareness of genetics among African-American nurses, a pilot study was conducted with members of the National Black Nurses Association (NBNA) in order to assess the interest, knowledge, and practice of African-American nurses regarding genetics and to identify program needs. Self-administered surveys were distributed to a convenience sample of 77 African-American nurses (N=77) attending the 2006 Annual Conference of the National Black Nurses Association (NBNA) in Hollywood, Florida. Measures of central tendency and frequencies were used to analyze the data. Over half the sample (56%) self-reported their knowledge of genetics as being only fair or poor; however, 56% were interested in genetic awareness training, and 93.5% were willing to participate in planned genomic education. An unexpected finding was that 77.9% believed that genetic tests could be used to discriminate against minorities. Although this sample reported limited genetics/genomic knowledge, their interest in genetics training and the incorporation of genetics into daily practice was high. These data can be used to support the development and implementation of culturally appropriate genetic awareness training. Challenges for the organization include identification of the type of venue to use for genetic/genomic awareness training and identification of resources and partnerships to support NBNA members in gaining genetic awareness training. PMID:20364722

  20. African-American heredity prostate cancer study: a model for genetic research.

    PubMed

    Powell, I J; Carpten, J; Dunston, G; Kittles, R; Bennett, J; Hoke, G; Pettaway, C; Weinrich, S; Vijayakumar, S; Ahaghotu, C A; Boykin, W; Mason, T; Royal, C; Baffoe-Bonnie, A; Bailey-Wilson, J; Berg, K; Trent, J; Collins, F

    2001-04-01

    A genome-wide scan of high-risk prostate cancer families in North America has demonstrated linkage of a particular marker to Chromosome 1q (HPC1). An even greater proportion of African-American families have shown linkage to HPC1. Therefore, investigators at the National Human Genome Research Institute (NHGRI) in collaboration with Howard University and a predominantly African-American group of urologists established the African-American Hereditary Prostate Cancer (AAHPC) Study Network to confirm the suggested linkage of HPC in African Americans with a gene on Chromosome 1. Blood samples from recruited families were sent to Howard University for extraction of DNA. The DNA was sent to NHGRI at NIH where the genotyping and genetic sequence analysis was conducted. Genotype data are merged with pedigree information so that statistical analysis can be performed to establish potential linkage. From March 1, 1998, to June 1, 1999, a total of 40 African-American families have been recruited who met the study criteria. Preliminary results suggest that racial/ethnicity grouping may affect the incidence and extent of linkage of prostate cancer to specific loci. The importance of these findings lays in the future treatment of genetic-based diseases.

  1. Obesity and African Americans

    MedlinePlus

    ... Data > Minority Population Profiles > Black/African American > Obesity Obesity and African Americans African American women have the ... ss6304.pdf [PDF | 3.38MB] HEALTH IMPACT OF OBESITY More than 80 percent of people with type ...

  2. Characterizing genetic risk at known prostate cancer susceptibility loci in African Americans.

    PubMed

    Haiman, Christopher A; Chen, Gary K; Blot, William J; Strom, Sara S; Berndt, Sonja I; Kittles, Rick A; Rybicki, Benjamin A; Isaacs, William B; Ingles, Sue A; Stanford, Janet L; Diver, W Ryan; Witte, John S; Chanock, Stephen J; Kolb, Suzanne; Signorello, Lisa B; Yamamura, Yuko; Neslund-Dudas, Christine; Thun, Michael J; Murphy, Adam; Casey, Graham; Sheng, Xin; Wan, Peggy; Pooler, Loreall C; Monroe, Kristine R; Waters, Kevin M; Le Marchand, Loic; Kolonel, Laurence N; Stram, Daniel O; Henderson, Brian E

    2011-05-01

    GWAS of prostate cancer have been remarkably successful in revealing common genetic variants and novel biological pathways that are linked with its etiology. A more complete understanding of inherited susceptibility to prostate cancer in the general population will come from continuing such discovery efforts and from testing known risk alleles in diverse racial and ethnic groups. In this large study of prostate cancer in African American men (3,425 prostate cancer cases and 3,290 controls), we tested 49 risk variants located in 28 genomic regions identified through GWAS in men of European and Asian descent, and we replicated associations (at p≤0.05) with roughly half of these markers. Through fine-mapping, we identified nearby markers in many regions that better define associations in African Americans. At 8q24, we found 9 variants (p≤6×10(-4)) that best capture risk of prostate cancer in African Americans, many of which are more common in men of African than European descent. The markers found to be associated with risk at each locus improved risk modeling in African Americans (per allele OR = 1.17) over the alleles reported in the original GWAS (OR = 1.08). In summary, in this detailed analysis of the prostate cancer risk loci reported from GWAS, we have validated and improved upon markers of risk in some regions that better define the association with prostate cancer in African Americans. Our findings with variants at 8q24 also reinforce the importance of this region as a major risk locus for prostate cancer in men of African ancestry.

  3. Genetics of Alzheimer's disease in Caribbean Hispanic and African American populations.

    PubMed

    Reitz, Christiane; Mayeux, Richard

    2014-04-01

    Late-onset Alzheimer's disease (LOAD), which is characterized by progressive deterioration in cognition, function, and behavior, is the most common cause of dementia and the sixth leading cause of all deaths, placing a considerable burden on Western societies. Most studies aiming to identify genetic susceptibility factors for LOAD have focused on non-Hispanic white populations. This is, in part related to differences in linkage disequilibrium and allele frequencies between ethnic groups that could lead to confounding. However, in addition, non-Hispanic white populations are simply more widely studied. As a consequence, minorities are genetically underrepresented despite the fact that in several minority populations living in the same community as whites (including African American and Caribbean Hispanics), LOAD incidence is higher. This review summarizes the current knowledge on genetic risk factors associated with LOAD risk in Caribbean Hispanics and African Americans and provides suggestions for future research. We focus on Caribbean Hispanics and African Americans because they have a high LOAD incidence and a body of genetic studies on LOAD that is based on samples with genome-wide association studies data and reasonably large effect sizes to yield generalizable results.

  4. The Primary Open-Angle African-American Glaucoma Genetics (POAAGG) Study: Baseline Demographics

    PubMed Central

    Charlson, Emily S.; Sankar, Prithvi S.; Miller-Ellis, Eydie; Regina, Meredith; Fertig, Raymond; Salinas, Julia; Pistilli, Maxwell; Salowe, Rebecca J.; Rhodes, Allison L.; Merritt, William T.; Chua, Michael; Trachtman, Benjamin T.; Gudiseva, Harini V.; Collins, David W.; Chavali, Venkata Ramana Murthy; Nichols, Charles; Henderer, Jeffrey; Ying, Gui-shuang; Varma, Rohit; Jorgenson, Eric

    2014-01-01

    Objective To describe the baseline characteristics of the Primary Open-Angle African-American Glaucoma Genetics (POAAGG) study cohort, the largest African-American primary open-angle glaucoma (POAG) population recruited at a single institution (University of Pennsylvania, Department of Ophthalmology, Scheie Eye Institute) to date. Design Population-based, cross-sectional, case-control study. Participants 2,520 African-American subjects 35 years and older, recruited from the greater Philadelphia, Pennsylvania area. Methods Each subject underwent a detailed interview and eye examination. The interview assessed demographic, behavioral, medical, and ocular risk factors. Current zip codes surrounding the University of Pennsylvania were recorded and United States census data were queried to infer socioeconomic status. The eye exam included measurement of visual acuity and intraocular pressure, a detailed anterior and posterior segment examination including gonioscopy, dilated fundus and optic disc examination, visual fields, stereo disc photography, optical coherence tomography imaging, and measurement of central corneal thickness. Main Outcome Measures The baseline characteristics of gender, age, and glaucoma diagnosis were collected. Body mass index (BMI), hypertension, diabetes, and alcohol and tobacco use, as well as ocular conditions including blindness, cataract, non-proliferative diabetic retinopathy, age-related macular degeneration, and use of ocular medication and surgery, were examined. Median population density, income, education level, and other socioeconomic measures were determined for the study cohort. Results Of the 2,520 African-Americans recruited to the POAAGG study to date, 2,067 (82.0%) including 807 controls and 1,260 POAG cases met all inclusion criteria and completed the detailed clinical ocular exam. Cases were more likely to have a lower BMI (p<0.01) and report a history of blindness (visual acuity of 20/200 or worse, p<0.001), while controls

  5. Fine-mapping of breast cancer susceptibility loci characterizes genetic risk in African Americans

    PubMed Central

    Chen, Fang; Chen, Gary K.; Millikan, Robert C.; John, Esther M.; Ambrosone, Christine B.; Bernstein, Leslie; Zheng, Wei; Hu, Jennifer J.; Ziegler, Regina G.; Deming, Sandra L.; Bandera, Elisa V.; Nyante, Sarah; Palmer, Julie R.; Rebbeck, Timothy R.; Ingles, Sue A.; Press, Michael F.; Rodriguez-Gil, Jorge L.; Chanock, Stephen J.; Le Marchand, Loïc; Kolonel, Laurence N.; Henderson, Brian E.; Stram, Daniel O.; Haiman, Christopher A.

    2011-01-01

    Genome-wide association studies (GWAS) have revealed 19 common genetic variants that are associated with breast cancer risk. Testing of the index signals found through GWAS and fine-mapping of each locus in diverse populations will be necessary for characterizing the role of these risk regions in contributing to inherited susceptibility. In this large study of breast cancer in African-American women (3016 cases and 2745 controls), we tested the 19 known risk variants identified by GWAS and replicated associations (P < 0.05) with only 4 variants. Through fine-mapping, we identified markers in four regions that better capture the association with breast cancer risk in African Americans as defined by the index signal (2q35, 5q11, 10q26 and 19p13). We also identified statistically significant associations with markers in four separate regions (8q24, 10q22, 11q13 and 16q12) that are independent of the index signals and may represent putative novel risk variants. In aggregate, the more informative markers found in the study enhance the association of these risk regions with breast cancer in African Americans [per allele odds ratio (OR) = 1.18, P = 2.8 × 10−24 versus OR = 1.04, P = 6.1 × 10−5]. In this detailed analysis of the known breast cancer risk loci, we have validated and improved upon markers of risk that better characterize their association with breast cancer in women of African ancestry. PMID:21852243

  6. Genetic Influences on Plasma Homocysteine Levels in African Americans and Yoruba Nigerians.

    PubMed

    Kim, Sungeun; Nho, Kwangsik; Ramanan, Vijay K; Lai, Dongbing; Foroud, Tatiana M; Lane, Katie; Murrell, Jill R; Gao, Sujuan; Hall, Kathleen S; Unverzagt, Frederick W; Baiyewu, Olusegun; Ogunniyi, Adesola; Gureje, Oye; Kling, Mitchel A; Doraiswamy, P Murali; Kaddurah-Daouk, Rima; Hendrie, Hugh C; Saykin, Andrew J

    2015-01-01

    Plasma homocysteine, a metabolite involved in key cellular methylation processes seems to be implicated in cognitive functions and cardiovascular health with its high levels representing a potential modifiable risk factor for Alzheimer's disease (AD) and other dementias. A better understanding of the genetic factors regulating homocysteine levels, particularly in non-white populations, may help in risk stratification analyses of existing clinical trials and may point to novel targets for homocysteine-lowering therapy. To identify genetic influences on plasma homocysteine levels in individuals with African ancestry, we performed a targeted gene and pathway-based analysis using a priori biological information and then to identify new association performed a genome-wide association study. All analyses used combined data from the African American and Yoruba cohorts from the Indianapolis-Ibadan Dementia Project. Targeted analyses demonstrated significant associations of homocysteine and variants within the CBS (Cystathionine beta-Synthase) gene. We identified a novel genome-wide significant association of the AD risk gene CD2AP (CD2-associated protein) with plasma homocysteine levels in both cohorts. Minor allele (T) carriers of identified CD2AP variant (rs6940729) exhibited decreased homocysteine level. Pathway enrichment analysis identified several interesting pathways including the GABA receptor activation pathway. This is noteworthy given the known antagonistic effect of homocysteine on GABA receptors. These findings identify several new targets warranting further investigation in relation to the role of homocysteine in neurodegeneration.

  7. Overlapping dopaminergic pathway genetic susceptibility to heroin and cocaine addictions in African Americans.

    PubMed

    Levran, Orna; Randesi, Matthew; da Rosa, Joel Correa; Ott, Jurg; Rotrosen, John; Adelson, Miriam; Kreek, Mary Jeanne

    2015-05-01

    Drugs of abuse activate the mesolimbic dopaminergic pathway. Genetic variations in the dopaminergic system may contribute to drug addiction. Several processes are shared between cocaine and heroin addictions but some neurobiological mechanisms may be specific. This study examined the association of 98 single nucleotide polymorphisms in 13 dopamine-related genes with heroin addiction (OD) and/or cocaine addiction (CD) in a sample of 801 African Americans (315 subjects with OD ± CD, 279 subjects with CD, and 207 controls). Single-marker analyses provided nominally significant evidence for associations of 24 SNPs) in DRD1, ANKK1/DRD2, DRD3, DRD5, DBH, DDC, COMT and CSNK1E. A DRD2 7-SNPs haplotype that includes SNPs rs1075650 and rs2283265, which were shown to alter D2S/D2L splicing, was indicated in both addictions. The Met allele of the functional COMT Val158Met was associated with protection from OD. None of the signals remained significant after correction for multiple testing. The study results are in accordance with the results of previous studies, including our report of association of DRD1 SNP rs5326 with OD. The findings suggest the presence of an overlap in genetic susceptibility for OD and CD, as well as shared and distinct susceptibility for OD in subjects of African and European descent. PMID:25875614

  8. The Genetic Contribution of West-African Ancestry to Protection against Central Obesity in African-American Men but Not Women: Results from the ARIC and MESA Studies

    PubMed Central

    Klimentidis, Yann C.; Arora, Amit; Zhou, Jin; Kittles, Rick; Allison, David B.

    2016-01-01

    Over 80% of African-American (AA) women are overweight or obese. A large racial disparity between AA and European-Americans (EA) in obesity rates exists among women, but curiously not among men. Although socio-economic and/or cultural factors may partly account for this race-by-sex interaction, the potential involvement of genetic factors has not yet been investigated. Among 2814 self-identified AA in the Atherosclerosis Risk in Communities study, we estimated each individual's degree of West-African genetic ancestry using 3437 ancestry informative markers. We then tested whether sex modifies the association between West-African genetic ancestry and body mass index (BMI), waist-circumference (WC), and waist-to-hip ratio (WHR), adjusting for income and education levels, and examined associations of ancestry with the phenotypes separately in males and females. We replicated our findings in the Multi-Ethnic Study of Atherosclerosis (n = 1611 AA). In both studies, we find that West-African ancestry is negatively associated with obesity, especially central obesity, among AA men, but not among AA women (pinteraction = 4.14 × 10−5 in pooled analysis of WHR). In conclusion, our results suggest that the combination of male gender and West-African genetic ancestry is associated with protection against central adiposity, and suggest that the large racial disparity that exists among women, but not men, may be at least partly attributed to genetic factors. PMID:27313598

  9. Genetic variants in microRNAs and breast cancer risk in African American and European American women

    PubMed Central

    Yao, Song; Graham, Kelly; Shen, Jie; Sucheston Campbell, Lara E.; Singh, Prashant; Zirpoli, Gary; Roberts, Michelle; Ciupak, Gregory; Davis, Warren; Hwang, Helena; Khoury, Thaer; Bovbjerg, Dana H.; Jandorf, Lina; Pawlish, Karen S.; Bandera, Elisa V.; Liu, Song; Ambrosone, Christine B.; Zhao, Hua

    2013-01-01

    MicroRNAs (miRNAs) are an integral part of the post-transcriptional machinery of gene expression and have been implicated in the carcinogenic cascade. Single nucleotide polymorphisms (SNPs) in miRNAs and risk of breast cancer have been evaluated in populations of European or Asian ancestry, but not among women of African ancestry. Here we examined 145 SNPs in 6 miRNA processing genes and in 78 miRNAs which target genes known to be important in breast cancer among 906 African American (AA) and 653 European American (EA) cases and controls enrolled in the Women’s Circle of Health Study (WCHS). Allele frequencies of most SNPs (87%) differed significantly by race. We found a number of SNPs in miRNAs and processing genes in association with breast cancer overall or stratified by estrogen receptor (ER) status. Several associations were significantly different by race, with none of the associations being significant in both races. Using a polygenic risk score to combine the effects of multiple SNPs, we found significant associations with the score in each subgroup analysis. For ER-positive cancer, each unit increment of the risk score was associated with a 51% increased risk in AAs (OR=1.51, 95% CI=1.30–1.74, p=3.3*10−8) and a 73% increased risk in EAs (OR=1.73, 95% CI=1.45–2.06, p=1.4*10−9). These data show, for the first time, that miRNA-related genetic variations may underlie the etiology of breast cancer in both populations of African and European ancestries. Future studies are needed to validate our findings and to explore the underlying mechanisms. PMID:24062209

  10. 16 Extraordinary African Americans.

    ERIC Educational Resources Information Center

    Lobb, Nancy

    This collection for children tells the stories of 16 African Americans who helped make America what it is today. African Americans can take pride in the heritage of these contributors to society. Biographies are given for the following: (1) Sojourner Truth, preacher and abolitionist; (2) Frederick Douglass, abolitionist; (3) Harriet Tubman, leader…

  11. Understanding African American Males

    ERIC Educational Resources Information Center

    Bell, Edward Earl

    2010-01-01

    The purpose of this study was to assess the socialization skills, self-esteem, and academic readiness of African American males in a school environment. Discussions with students and the School Perceptions Questionnaire provided data for this investigation. The intended targets for this investigation were African American students; however, there…

  12. Brief Report: Under-Representation of African Americans in Autism Genetic Research--A Rationale for Inclusion of Subjects Representing Diverse Family Structures

    ERIC Educational Resources Information Center

    Hilton, Claudia L.; Fitzgerald, Robert T.; Jackson, Kelley M.; Maxim, Rolanda A.; Bosworth, Christopher C.; Shattuck, Paul T.; Geschwind, Daniel H.; Constantino, John N.

    2010-01-01

    African American children with autism are seriously under-represented in existing genetic registries and biomedical research studies of autism. We estimated the number of African American children with autism in the St. Louis region using CDC surveillance data and present the outcomes of a concerted effort to enroll approximately one-third of that…

  13. African ancestry and its correlation to type 2 diabetes in African Americans: a genetic admixture analysis in three U.S. population cohorts.

    PubMed

    Cheng, Ching-Yu; Reich, David; Haiman, Christopher A; Tandon, Arti; Patterson, Nick; Selvin, Elizabeth; Elizabeth, Selvin; Akylbekova, Ermeg L; Brancati, Frederick L; Coresh, Josef; Boerwinkle, Eric; Altshuler, David; Taylor, Herman A; Henderson, Brian E; Wilson, James G; Kao, W H Linda

    2012-01-01

    The risk of type 2 diabetes is approximately 2-fold higher in African Americans than in European Americans even after adjusting for known environmental risk factors, including socioeconomic status (SES), suggesting that genetic factors may explain some of this population difference in disease risk. However, relatively few genetic studies have examined this hypothesis in a large sample of African Americans with and without diabetes. Therefore, we performed an admixture analysis using 2,189 ancestry-informative markers in 7,021 African Americans (2,373 with type 2 diabetes and 4,648 without) from the Atherosclerosis Risk in Communities Study, the Jackson Heart Study, and the Multiethnic Cohort to 1) determine the association of type 2 diabetes and its related quantitative traits with African ancestry controlling for measures of SES and 2) identify genetic loci for type 2 diabetes through a genome-wide admixture mapping scan. The median percentage of African ancestry of diabetic participants was slightly greater than that of non-diabetic participants (study-adjusted difference = 1.6%, P<0.001). The odds ratio for diabetes comparing participants in the highest vs. lowest tertile of African ancestry was 1.33 (95% confidence interval 1.13-1.55), after adjustment for age, sex, study, body mass index (BMI), and SES. Admixture scans identified two potential loci for diabetes at 12p13.31 (LOD = 4.0) and 13q14.3 (Z score = 4.5, P = 6.6 × 10(-6)). In conclusion, genetic ancestry has a significant association with type 2 diabetes above and beyond its association with non-genetic risk factors for type 2 diabetes in African Americans, but no single gene with a major effect is sufficient to explain a large portion of the observed population difference in risk of diabetes. There undoubtedly is a complex interplay among specific genetic loci and non-genetic factors, which may both be associated with overall admixture, leading to the observed ethnic differences in diabetes risk.

  14. Overlapping Dopaminergic Pathway Genetic Susceptibility for Heroin and Cocaine Addictions in African Americans

    PubMed Central

    Levran, Orna; Randesi, Matthew; da Rosa, Joel Correa; Ott, Jurg; Rotrosen, John; Adelson, Miriam; Kreek, Mary Jeanne

    2015-01-01

    Summary Drugs of abuse activate the mesolimbic dopaminergic pathway. Genetic variations in the dopaminergic system may contribute to vulnerability to drug addiction. Several processes are shared between cocaine and heroin addictions but some neurobiological mechanisms and environmental influence may be specific. This study examined the association of 98 single nucleotide polymorphisms (SNPs) in 13 dopamine pathway-related genes with heroin and/or cocaine addiction in a sample of 801 African Americans (315 subjects with heroin addiction (OD), with or without cocaine (CD) or alcohol addiction (AD), 279 subjects with CD, with or without AD, and 207 controls). Single-marker analyses provided nominally significant evidence for associations of 24 SNPs in DRD1, ANKK1/DRD2, DRD3, DRD5, DBH, DDC, COMT and CSNK1E with OD and/or CD. A DRD2 7-SNPs haplotype block that includes SNPs rs1075650 and rs2283265, which were shown to alter D2S/D2L splicing, was indicated in both addictions. The Met allele of the COMT Val158Met functional variant was associated with protection from OD. None of the signals remained significant after correction for multiple testing. The study results are in accordance with the results of several previous studies, including our report of association of DRD1 SNP rs5326 with OD in a smaller sample from this cohort. The findings suggest the presence of an overlap in the genetic liability for heroin and cocaine addictions, as well as shared and distinct liability for OD in subjects of African and European descent. PMID:25875614

  15. Genetic variants of GSNOR and ADRB2 influence response to albuterol in African-American children with severe asthma.

    PubMed

    Moore, Paul E; Ryckman, Kelli K; Williams, Scott M; Patel, Neal; Summar, Marshall L; Sheller, James R

    2009-07-01

    African Americans are disproportionately affected by asthma. Social and economic factors play a role in this disparity, but there is evidence that genetic factors may also influence the development of asthma and response to therapy in African American children. Our hypothesis is that variations in asthma related genes contribute to the observed asthma disparities by influencing the response to asthma-specific therapy. In order to test this hypothesis, we characterized the clinical response to asthma-specific therapy in 107 African American children who presented to the emergency room in status asthmaticus, with a primary outcome indicator of length of time on continuous albuterol. Single locus analysis indicated that genotype variation in glutathione-dependent S-nitrosoglutathione reductase (GSNOR) is associated with a decreased response to asthma treatment in African American children. A post hoc multi-locus analysis revealed that a combination of four single nucleotide polymorphisms (SNPs) within GSNOR, adrenergic receptor beta 2, and carbamoyl phosphate synthetase-1 give a 70% predictive value for lack of response to therapy. This predictive model needs replication in other cohorts of patients with asthma, but suggests gene-gene interactions may have greater significance than that identified with single variants. Our findings also suggest that genetic variants may contribute to the observed population disparities in asthma. PMID:19514054

  16. A genetic association study of activated partial thromboplastin time in European Americans and African Americans: the ARIC Study.

    PubMed

    Weng, Lu-Chen; Cushman, Mary; Pankow, James S; Basu, Saonli; Boerwinkle, Eric; Folsom, Aaron R; Tang, Weihong

    2015-04-15

    Reduced activated partial thromboplastin time (aPTT) is a risk marker for incident and recurrent venous thromboembolism (VTE). Genetic factors influencing aPTT are not well understood, especially in populations of non-European ancestry. The present study aimed to identify aPTT-related gene variants in both European Americans (EAs) and African Americans (AAs). We conducted a genetic association study for aPTT in 9719 EAs and 2799 AAs from the Atherosclerosis Risk in Communities (ARIC) study. Using the Candidate Gene Association Resource (CARe) consortium candidate gene array, the analyses were based on ∼50 000 SNPs in ∼2000 candidate genes. In EAs, the analyses identified a new independent association for aPTT in F5 (rs2239852, P-value = 1.9 × 10(-8)), which clusters with a coding variant rs6030 (P-value = 7.8 × 10(-7)). The remaining significant signals were located on F5, HRG, KNG1, F11, F12 and ABO and have been previously reported in EA populations. In AAs, significant signals were identified in KNG1, HRG, F12, ABO and VWF, with the leading variants in KNG1, HRG and F12 being the same as in the EAs; the significant variant in VWF (rs2229446, P-value = 1.2 × 10(-6)) was specific to the AA sample (minor allele frequency = 19% in AAs and 0.2% in EAs) and has not been previously reported. This is the first study to report aPTT-related genetic variants in AAs. Our findings in AAs demonstrate transferability of previously reported associations with KNG1, HRG and F12 in EAs. We also identified new associations at F5 in EAs and VWF in AAs that have not been previously reported for aPTT. PMID:25552651

  17. A genetic association study of activated partial thromboplastin time in European Americans and African Americans: the ARIC Study

    PubMed Central

    Weng, Lu-Chen; Cushman, Mary; Pankow, James S.; Basu, Saonli; Boerwinkle, Eric; Folsom, Aaron R.; Tang, Weihong

    2015-01-01

    Reduced activated partial thromboplastin time (aPTT) is a risk marker for incident and recurrent venous thromboembolism (VTE). Genetic factors influencing aPTT are not well understood, especially in populations of non-European ancestry. The present study aimed to identify aPTT-related gene variants in both European Americans (EAs) and African Americans (AAs). We conducted a genetic association study for aPTT in 9719 EAs and 2799 AAs from the Atherosclerosis Risk in Communities (ARIC) study. Using the Candidate Gene Association Resource (CARe) consortium candidate gene array, the analyses were based on ∼50 000 SNPs in ∼2000 candidate genes. In EAs, the analyses identified a new independent association for aPTT in F5 (rs2239852, P-value = 1.9 × 10−8), which clusters with a coding variant rs6030 (P-value = 7.8 × 10−7). The remaining significant signals were located on F5, HRG, KNG1, F11, F12 and ABO and have been previously reported in EA populations. In AAs, significant signals were identified in KNG1, HRG, F12, ABO and VWF, with the leading variants in KNG1, HRG and F12 being the same as in the EAs; the significant variant in VWF (rs2229446, P-value = 1.2 × 10−6) was specific to the AA sample (minor allele frequency = 19% in AAs and 0.2% in EAs) and has not been previously reported. This is the first study to report aPTT-related genetic variants in AAs. Our findings in AAs demonstrate transferability of previously reported associations with KNG1, HRG and F12 in EAs. We also identified new associations at F5 in EAs and VWF in AAs that have not been previously reported for aPTT. PMID:25552651

  18. Host Genetics, Steatosis and Insulin Resistance among African Americans and Caucasian Americans with Hepatitis C Virus Genotype-1 Infection

    PubMed Central

    Iuliano, A. Danielle; Feingold, Eleanor; Wahed, Abdus S.; Kleiner, David E.; Belle, Steven H.; Conjeevaram, Hari S.; Zmuda, Joseph; Liang, T. Jake; Yee, Leland J.

    2009-01-01

    Hepatic steatosis is the accumulation of fat in liver cells. Insulin resistance (IR) occurs when normal amounts of insulin do not stimulate insulin activity in cells. Both conditions have been described in hepatitis C virus (HCV) infection and are thought to be biologically related. This study examined the association of genetic variants with steatosis and IR among 167 African Americans and 184 Caucasian Americans with HCV genotype-1. Steatosis was defined as at least 5% of fat in cells on liver biopsy. IR was quantified as a score greater than 2 from the Homeostasis Model Assessment, version 2.2 (HOMA2-IR). Associations were investigated by estimating odds ratios separately by race. Statistically significant associations (p < 0.05) were observed for variants in interleukin-10 (IL10), leptin receptor (LEPR), interleukin-6 (IL6) and transforming growth factor beta-1 (TGF-β1) for both outcomes. Some significant interactions were observed between IL10, LEPR andTGF-β1 polymorphisms and HOMA2-IR scores when examining steatosis. The interaction of HOMA2-IR and IL10 was consistent in both races whereas for LEPR and TGF-β1 the interactions were statistically significant in only one of the racial groups. These results could imply that some IL10, LEPR and TGF-β1 polymorphisms may modify an association between steatosis and IR. PMID:19401628

  19. An initial investigation of associations between dopamine-linked genetic variation and smoking motives in African Americans.

    PubMed

    Bidwell, L C; McGeary, J E; Gray, J C; Palmer, R H C; Knopik, V S; MacKillop, J

    2015-11-01

    Nicotine dependence (ND) is a heterogeneous phenotype with complex genetic influences that may vary across ethnicities. The use of intermediate phenotypes may clarify genetic influences and reveal specific etiological pathways. Prior work in European Americans has found that the four Primary Dependence Motives (PDM) subscales (Automaticity, Craving, Loss of Control, and Tolerance) of the Wisconsin Inventory of Smoking Motives represent core features of nicotine dependence and are promising intermediate phenotypes for understanding genetic pathways to ND. However, no studies have examined PDM as an intermediate phenotype in African American smokers, an ethnic population that displays unique patterns of smoking and genetic variation. In the current study, 268 African American daily smokers completed a phenotypic assessment and provided a sample of DNA. Associations among haplotypes in the NCAM1-TTC12-ANKK1-DRD2 gene cluster, a dopamine-related gene region associated with ND, PDM intermediate phenotypes, and ND were examined. Dopamine-related genetic variation in the DBH and COMT genes was also considered on an exploratory basis. Mediational analysis was used to test the indirect pathway from genetic variation to smoking motives to nicotine dependence. NCAM1-TTC12-ANKK1-DRD2 region variation was significantly associated with the Automaticity subscale and, further, Automaticity significantly mediated associations among NCAM1-TTC12-ANKK1-DRD2 cluster variants and ND. DBH was also significantly associated with Automaticity, Craving, and Tolerance; Automaticity and Tolerance also served as mediators of the DBH-ND relationship. These results suggest that PDM, Automaticity in particular, may be a viable intermediate phenotype for understanding dopamine-related genetic influences on ND in African American smokers. Findings support a model in which putatively dopaminergic variants exert influence on ND through an effect on patterns of automatic routinized smoking. PMID

  20. Reflections and perspectives of African-American community leaders regarding genetics and genomics research: sentiment and wisdom of Sankofa.

    PubMed

    Underwood, Sandra Millon; Buseh, Aaron G; Stevens, Patricia E; Townsend, Leolia; Kelber, Sheryl T

    2013-07-01

    Advances in genetic and genomic research are shifting the typical disease timeline. For those afflicted by disease and for population groups known to experience excess disease-related morbidity and mortality, the ability to use genetics and genomics to predict an individuals' predisposition for developing a disease and/or to anticipate an individual's response to treatments holds tremendous promise. Over the past two decades several public and private institutions within the United States have been established for the purpose of collecting and storing biological specimens for the purpose of conducting genetic/genomic research. Multiple reports indicate that the involvement of racial/ethnic minority participants in these bio-repositories is limited. Little is known about the willingness of African-Americans, one of the largest and most vulnerable racial/ethnic population groups, to participate in genetic research, genomic research, and to contribute biological specimens to bio-repositories. An exploratory study was undertaken using principles of community engagement and community-based participatory research to examine the perspectives of leaders within the African-American community about participation in genetics research, genomics research, and bio-banking. Semi-structured focus groups with twenty-one African-American community leaders were the primary means of gathering the study data. Reflections and commentary of the community leaders were interspersed with sentiments of "Sankofa." The emergent themes, health-related disparities, historical injustices in medical research, the promise of genetic and genomic research, and genetics/genomic research engagement, implicated the importance of conducting genetics/genomics research in the context of the community interdependent with efforts to address determinants of health and health disparities.

  1. Educating African American Males

    ERIC Educational Resources Information Center

    Bell, Edward E.

    2010-01-01

    Background: Schools across America spend money, invest in programs, and sponsor workshops, offer teacher incentives, raise accountability standards, and even evoke the name of Obama in efforts to raise the academic achievement of African American males. Incarceration and college retention rates point to a dismal plight for many African American…

  2. Common biological networks underlie genetic risk for alcoholism in African- and European-American populations.

    PubMed

    Kos, M Z; Yan, J; Dick, D M; Agrawal, A; Bucholz, K K; Rice, J P; Johnson, E O; Schuckit, M; Kuperman, S; Kramer, J; Goate, A M; Tischfield, J A; Foroud, T; Nurnberger, J; Hesselbrock, V; Porjesz, B; Bierut, L J; Edenberg, H J; Almasy, L

    2013-07-01

    Alcohol dependence (AD) is a heritable substance addiction with adverse physical and psychological consequences, representing a major health and economic burden on societies worldwide. Genes thus far implicated via linkage, candidate gene and genome-wide association studies (GWAS) account for only a small fraction of its overall risk, with effects varying across ethnic groups. Here we investigate the genetic architecture of alcoholism and report on the extent to which common, genome-wide SNPs collectively account for risk of AD in two US populations, African-Americans (AAs) and European-Americans (EAs). Analyzing GWAS data for two independent case-control sample sets, we compute polymarker scores that are significantly associated with alcoholism (P = 1.64 × 10(-3) and 2.08 × 10(-4) for EAs and AAs, respectively), reflecting the small individual effects of thousands of variants derived from patterns of allelic architecture that are population specific. Simulations show that disease models based on rare and uncommon causal variants (MAF < 0.05) best fit the observed distribution of polymarker signals. When scoring bins were annotated for gene location and examined for constituent biological networks, gene enrichment is observed for several cellular processes and functions in both EA and AA populations, transcending their underlying allelic differences. Our results reveal key insights into the complex etiology of AD, raising the possibility of an important role for rare and uncommon variants, and identify polygenic mechanisms that encompass a spectrum of disease liability, with some, such as chloride transporters and glycine metabolism genes, displaying subtle, modifying effects that are likely to escape detection in most GWAS designs.

  3. Genetic variants in the mTOR pathway and breast cancer risk in African American women.

    PubMed

    Cheng, Ting-Yuan David; Ambrosone, Christine B; Hong, Chi-Chen; Lunetta, Kathryn L; Liu, Song; Hu, Qiang; Yao, Song; Sucheston-Campbell, Lara; Bandera, Elisa V; Ruiz-Narváez, Edward A; Haddad, Stephen; Troester, Melissa A; Haiman, Christopher A; Bensen, Jeannette T; Olshan, Andrew F; Palmer, Julie R; Rosenberg, Lynn

    2016-01-01

    The phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin (mTOR) pathway has been implicated in breast carcinogenesis. However, there has been no large-scale investigation of genetic variants in the mTOR pathway and breast cancer risk. We examined 28847 single-nucleotide polymorphisms (SNPs) in 61 mTOR pathway genes in the African American Breast Cancer Epidemiology and Risk consortium of 3663 cases [1983 estrogen receptor-positive (ER+) and 1098 ER-negative (ER-)] and 4687 controls. Gene-level analyses were conducted using the adaptive rank truncated product (ARTP) test for 10773 SNPs that were not highly correlated (r (2) < 0.8), and SNP-level analyses were conducted with logistic regression. Among genes that were prioritized (nominal P < 0.05, ARTP tests), associations were observed for intronic SNPs TSC2 rs181088346 [odds ratio (OR) of each copy of variant allele = 0.77, 95% confidence interval (CI) = 0.65-0.88 for all breast cancer] and BRAF rs114729114 (OR = 1.53, 95% CI = 1.24-1.91 for all breast cancer and OR = 2.03, 95% CI = 1.50-2.76 for ER- tumors). For ER- tumors, intronic SNPs PGF rs11542848 (OR = 1.38, 95% CI = 1.15-1.66) and rs61759375 (OR = 1.34, 95% CI = 1.14-1.57) and MAPK3 rs78564187 (OR = 1.26, 95% CI = 1.11-1.43) were associated with increased risk. These SNPs were significant at a gene-wide level (Bonferroni-corrected P < 0.05). The variant allele of RPS6KB2 rs35363135, a synonymous coding SNP, was more likely to be observed in ER- than ER+ tumors (OR = 1.18, 95% CI = 1.05-1.31, gene-wide Bonferroni-corrected P = 0.06). In conclusion, specific mTOR pathway genes are potentially important to breast cancer risk and to the ER negativity in African American women. PMID:26577839

  4. African-Americans and Alzheimer's

    MedlinePlus

    ... Share Plus on Google Plus African-Americans and Alzheimer's alz.org | IHaveAlz Introduction 10 Warning Signs Brain ... African-Americans are at a higher risk for Alzheimer's disease. Many Americans dismiss the warning signs of ...

  5. Stress, relationship satisfaction, and health among African American women: Genetic moderation of effects.

    PubMed

    Lei, Man-Kit; Beach, Steven R H; Simons, Ronald L; Barr, Ashley B; Cutrona, Carolyn E; Philibert, Robert A

    2016-03-01

    We examined whether romantic relationship satisfaction would serve as a link between early and later stressors which in turn would influence the thyroid function index (TFI), an indicator of physiological stress response. Using the framework of genetic susceptibility theory combined with hypotheses derived from the vulnerability-stress-adaptation and stress-generation models, we tested whether the hypothesized mediational model would be conditioned by 5-HTTLPR genotype, with greater effects and stronger evidence of mediation among carriers of the "s" allele. In a sample of African American women in romantic relationships (n = 270), we found that 5-HTTLPR moderated each stage of the hypothesized mediational model in a "for better or for worse" manner. That is genetic polymorphisms function to exacerbate not only the detrimental impact of negative environments (i.e., "for worse effects") but also the beneficial impact of positive environments (i.e., "for better effects"). The effect of early stress on relationship satisfaction was greater among carriers of the "short" allele than among those who did not carry the short allele, and was significantly different in both the "for better" and "for worse" direction. Likewise, the effect of relationship satisfaction on later stressors was moderated in a "for better "or "for worse" manner. Finally, impact on physiological stress, indexed using TFI level, indicated that the impact of later stressors on TFI level was greater in the presence of the short allele, and also followed a "for better" or "for worse" pattern. As expected, the proposed mediational model provided a better fit for "s" allele carriers.

  6. Stress, relationship satisfaction, and health among African American women: Genetic moderation of effects.

    PubMed

    Lei, Man-Kit; Beach, Steven R H; Simons, Ronald L; Barr, Ashley B; Cutrona, Carolyn E; Philibert, Robert A

    2016-03-01

    We examined whether romantic relationship satisfaction would serve as a link between early and later stressors which in turn would influence the thyroid function index (TFI), an indicator of physiological stress response. Using the framework of genetic susceptibility theory combined with hypotheses derived from the vulnerability-stress-adaptation and stress-generation models, we tested whether the hypothesized mediational model would be conditioned by 5-HTTLPR genotype, with greater effects and stronger evidence of mediation among carriers of the "s" allele. In a sample of African American women in romantic relationships (n = 270), we found that 5-HTTLPR moderated each stage of the hypothesized mediational model in a "for better or for worse" manner. That is genetic polymorphisms function to exacerbate not only the detrimental impact of negative environments (i.e., "for worse effects") but also the beneficial impact of positive environments (i.e., "for better effects"). The effect of early stress on relationship satisfaction was greater among carriers of the "short" allele than among those who did not carry the short allele, and was significantly different in both the "for better" and "for worse" direction. Likewise, the effect of relationship satisfaction on later stressors was moderated in a "for better "or "for worse" manner. Finally, impact on physiological stress, indexed using TFI level, indicated that the impact of later stressors on TFI level was greater in the presence of the short allele, and also followed a "for better" or "for worse" pattern. As expected, the proposed mediational model provided a better fit for "s" allele carriers. PMID:26376424

  7. The Other African Americans.

    ERIC Educational Resources Information Center

    Matory, J. Lorand

    Black North America is ethnically and culturally diverse. It contains many groups who do not call themselves or have not always called themselves "Negro,""Black,""African-American," and so forth, such as Louisiana Creoles of color and many of the Indian tribes east of the Mississippi. There are also numerous North American ethnic groups of African…

  8. Comparison of Statistical Methods for Estimating Genetic Admixture in a Lung Cancer Study of African Americans and Latinos

    PubMed Central

    Selvin, Steve; Hansen, Helen M.; Barcellos, Lisa F.; Wrensch, Margaret R.; Sison, Jennette D.; Quesenberry, Charles P.; Kittles, Rick A.; Silva, Gabriel; Buffler, Patricia A.; Seldin, Michael F.; Wiencke, John K.

    2008-01-01

    A variety of methods are available for estimating genetic admixture proportions in populations; however, few investigators have conducted detailed comparisons using empirical data. The authors characterized admixture proportions among self-identified African Americans (n = 535) and Latinos (n = 412) living in the San Francisco Bay Area who participated in a lung cancer case-control study (1998–2003). Individual estimates of genetic ancestry based on 184 informative markers were obtained from a Bayesian approach and 2 maximum likelihood approaches and were compared using descriptive statistics, Pearson correlation coefficients, and Bland-Altman plots. Case-control differences in individual admixture proportions were assessed using 2-sample t tests and logistic regression analysis. Results indicated that Bayesian and frequentist approaches to estimating admixture provide similar estimates and inferences. No difference was observed in admixture proportions between African-American cases and controls, but Latino cases and controls significantly differed according to Amerindian and European genetic ancestry. Differences in admixture proportions between Latino cases and controls were not unexpected, since cases were more likely to have been born in the United States. Genetic admixture proportions provide a quantitative measure of ancestry differences among Latinos that can be used in analyses of genetic risk factors. PMID:18791191

  9. Genetics of coronary artery calcification among African Americans, a meta-analysis

    PubMed Central

    2013-01-01

    Background Coronary heart disease (CHD) is the major cause of death in the United States. Coronary artery calcification (CAC) scores are independent predictors of CHD. African Americans (AA) have higher rates of CHD but are less well-studied in genomic studies. We assembled the largest AA data resource currently available with measured CAC to identify associated genetic variants. Methods We analyzed log transformed CAC quantity (ln(CAC + 1)), for association with ~2.5 million single nucleotide polymorphisms (SNPs) and performed an inverse-variance weighted meta-analysis on results for 5,823 AA from 8 studies. Heritability was calculated using family studies. The most significant SNPs among AAs were evaluated in European Ancestry (EA) CAC data; conversely, the significance of published SNPs for CAC/CHD in EA was queried within our AA meta-analysis. Results Heritability of CAC was lower in AA (~30%) than previously reported for EA (~50%). No SNP reached genome wide significance (p < 5E-08). Of 67 SNPs with p < 1E-05 in AA there was no evidence of association in EA CAC data. Four SNPs in regions previously implicated in CAC/CHD (at 9p21 and PHACTR1) in EA reached nominal significance for CAC in AA, with concordant direction. Among AA, rs16905644 (p = 4.08E-05) had the strongest association in the 9p21 region. Conclusions While we observed substantial heritability for CAC in AA, we failed to identify loci for CAC at genome-wide significant levels despite having adequate power to detect alleles with moderate to large effects. Although suggestive signals in AA were apparent at 9p21 and additional CAC and CAD EA loci, overall the data suggest that even larger samples and an ethnic specific focus will be required for GWAS discoveries for CAC in AA populations. PMID:23870195

  10. The African American Image in American Cinema.

    ERIC Educational Resources Information Center

    Bourne, St. Clair

    1990-01-01

    Political conditions have influenced the screen images of U.S. cinema, and the images of African Americans have reflected prevailing social stereotypes. The history of African-American representation in films is traced, and it is noted that the tendency to portray African Americans stereotypically has not changed. (SLD)

  11. Meta-analysis of genome-wide association studies identifies genetic risk factors for stroke in African-Americans

    PubMed Central

    Carty, Cara L.; Keene, Keith L.; Cheng, Yu-Ching; Meschia, James F.; Chen, Wei-Min; Nalls, Mike; Bis, Joshua C.; Kittner, Steven J.; Rich, Stephen S.; Tajuddin, Salman; Zonderman, Alan B.; Evans, Michele K.; Langefeld, Carl D.; Gottesman, Rebecca; Mosley, Thomas H.; Shahar, Eyal; Woo, Daniel; Yaffe, Kristine; Liu, YongMei; Sale, Michèle M.; Dichgans, Martin; Malik, Rainer; Longstreth, WT; Mitchell, Braxton D.; Psaty, Bruce M.; Kooperberg, Charles; Reiner, Alexander; Worrall, Bradford B.; Fornage, Myriam

    2015-01-01

    Background and Purpose The majority of genome-wide association studies (GWAS) of stroke have focused on European-ancestry populations; however, none has been conducted in African-Americans despite the disproportionately high burden of stroke in this population. The Consortium of Minority Population genome-wide Association Studies of Stroke (COMPASS) was established to identify stroke susceptibility loci in minority populations. Methods Using METAL, we conducted meta-analyses of GWAS in 14,746 African-Americans (1,365 ischemic and 1,592 total stroke cases) from COMPASS, and tested SNPs with P<10−6 for validation in METASTROKE, a consortium of ischemic stroke genetic studies in European-ancestry populations. We also evaluated stroke loci previously identified in European-ancestry populations. Results The 15q21.3 locus linked with lipid levels and hypertension was associated with total stroke (rs4471613, P=3.9×10−8) in African-Americans. Nominal associations (P<10−6) for total or ischemic stroke were observed for 18 variants in or near genes implicated in cell cycle/ mRNA pre-splicing (PTPRG, CDC5L), platelet function (HPS4), blood-brain barrier permeability (CLDN17), immune response (ELTD1, WDFY4, IL1F10-IL1RN), and histone modification (HDAC9). Two of these loci achieved nominal significance in METASTROKE: 5q35.2 (P=0.03), and 1p31.1 (P=0.018). Four of 7 previously reported ischemic stroke loci (PITX2, HDAC9, CDKN2A/CDKN2B and ZFHX3) were nominally associated (P<0.05) with stroke in COMPASS. Conclusions We identified a novel SNP associated with total stroke in African-Americans and found that ischemic stroke loci identified in European-ancestry populations may also be relevant for African-Americans. Our findings support investigation of diverse populations to identify and characterize genetic risk factors, and the importance of shared genetic risk across populations. PMID:26089329

  12. Perceptions of African-American Health Professionals and Community Members on Participation of Children and Pregnant Women in Genetic Research

    PubMed Central

    Ngui, Emmanuel M.; Warner, Teddy D.; Roberts, Laura Weiss

    2014-01-01

    Background As genetic research gains more prominence in society, ethical concerns and the need for safeguards in the participation of children and pregnant women have increased. This study examined the perspectives of African-American health professional and community members on genetic research involving children and pregnant women. Methods We used a mixed methods approach to collect and analyze survey data and qualitative data from focus groups of community members and structured interviews of health professionals. Results We found that community members had significantly more favorable attitudes toward participation of children and pregnant women in genetic research than health professionals. Health professionals did not differ significantly from community members in their perceived understanding of genetic research. Emergent themes included limited knowledge of genetic research and distinction of biomedical research and clinical care, ethical concerns about confidentiality, and potential harm and the need to protect children and pregnant women. Participants expressed high interest and favorable attitude towards genetic research, despite limited genetic knowledge and concerns of potential harm to children and pregnant women. Some participants felt that genetic research findings could help dispel stigma and reduce discrimination, especially in mental illness. Conclusion Findings suggest that the recruitment of participants into genetic research should directly address privacy and benefit concerns, and limited knowledge of physical and mental illness genetic research. There is a critical need to invest and engage racial/ethnic communities early, provide education on genetics, mental illness, and translate and share research findings with these communities. PMID:24216722

  13. The Potential for Enhancing the Power of Genetic Association Studies in African Americans through the Reuse of Existing Genotype Data

    PubMed Central

    Chen, Gary K.; Millikan, Robert C.; John, Esther M.; Ambrosone, Christine B.; Bernstein, Leslie; Zheng, Wei; Hu, Jennifer J.; Chanock, Stephen J.; Ziegler, Regina G.; Bandera, Elisa V.; Henderson, Brian E.; Haiman, Christopher A.; Stram, Daniel O.

    2010-01-01

    We consider the feasibility of reusing existing control data obtained in genetic association studies in order to reduce costs for new studies. We discuss controlling for the population differences between cases and controls that are implicit in studies utilizing external control data. We give theoretical calculations of the statistical power of a test due to Bourgain et al (Am J Human Genet 2003), applied to the problem of dealing with case-control differences in genetic ancestry related to population isolation or population admixture. Theoretical results show that there may exist bounds for the non-centrality parameter for a test of association that places limits on study power even if sample sizes can grow arbitrarily large. We apply this method to data from a multi-center, geographically-diverse, genome-wide association study of breast cancer in African-American women. Our analysis of these data shows that admixture proportions differ by center with the average fraction of European admixture ranging from approximately 20% for participants from study sites in the Eastern United States to 25% for participants from West Coast sites. However, these differences in average admixture fraction between sites are largely counterbalanced by considerable diversity in individual admixture proportion within each study site. Our results suggest that statistical correction for admixture differences is feasible for future studies of African-Americans, utilizing the existing controls from the African-American Breast Cancer study, even if case ascertainment for the future studies is not balanced over the same centers or regions that supplied the controls for the current study. PMID:20824062

  14. Contribution of Genome-Wide HCV Genetic Differences to Outcome of Interferon-Based Therapy in Caucasian American and African American Patients

    PubMed Central

    Donlin, Maureen J.; Cannon, Nathan A.; Aurora, Rajeev; Li, Jia; Wahed, Abdus S.; Di Bisceglie, Adrian M.; Tavis, John E.

    2010-01-01

    Background Hepatitis C virus (HCV) has six major genotypes, and patients infected with genotype 1 respond less well to interferon-based therapy than other genotypes. African American patients respond to interferon α-based therapy at about half the rate of Caucasian Americans. The effect of HCV's genetic variation on treatment outcome in both racial groups is poorly understood. Methodology We determined the near full-length pre-therapy consensus sequences from 94 patients infected with HCV genotype 1a or 1b undergoing treatment with peginterferon α-2a and ribavirin through the Virahep-C study. The sequences were stratified by genotype, race and treatment outcome to identify HCV genetic differences associated with treatment efficacy. Principal Findings HCV sequences from patients who achieved sustained viral response were more diverse than sequences from non-responders. These inter-patient diversity differences were found primarily in the NS5A gene in genotype 1a and in core and NS2 in genotype 1b. These differences could not be explained by host selection pressures. Genotype 1b but not 1a African American patients had viral genetic differences that correlated with treatment outcome. Conclusions & Significance Higher inter-patient viral genetic diversity correlated with successful treatment, implying that there are HCV genotype 1 strains with intrinsic differences in sensitivity to therapy. Core, NS3 and NS5A have interferon-suppressive activities detectable through in vitro assays, and hence these activities also appear to function in human patients. Both preferential infection with relatively resistant HCV variants and host-specific factors appear to contribute to the unusually poor response to therapy in African American patients. PMID:20140258

  15. Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study

    PubMed Central

    Fox, Ervin R.; Young, J. Hunter; Li, Yali; Dreisbach, Albert W.; Keating, Brendan J.; Musani, Solomon K.; Liu, Kiang; Morrison, Alanna C.; Ganesh, Santhi; Kutlar, Abdullah; Ramachandran, Vasan S.; Polak, Josef F.; Fabsitz, Richard R.; Dries, Daniel L.; Farlow, Deborah N.; Redline, Susan; Adeyemo, Adebowale; Hirschorn, Joel N.; Sun, Yan V.; Wyatt, Sharon B.; Penman, Alan D.; Palmas, Walter; Rotter, Jerome I.; Townsend, Raymond R.; Doumatey, Ayo P.; Tayo, Bamidele O.; Mosley, Thomas H.; Lyon, Helen N.; Kang, Sun J.; Rotimi, Charles N.; Cooper, Richard S.; Franceschini, Nora; Curb, J. David; Martin, Lisa W.; Eaton, Charles B.; Kardia, Sharon L.R.; Taylor, Herman A.; Caulfield, Mark J.; Ehret, Georg B.; Johnson, Toby; Chakravarti, Aravinda; Zhu, Xiaofeng; Levy, Daniel; Munroe, Patricia B.; Rice, Kenneth M.; Bochud, Murielle; Johnson, Andrew D.; Chasman, Daniel I.; Smith, Albert V.; Tobin, Martin D.; Verwoert, Germaine C.; Hwang, Shih-Jen; Pihur, Vasyl; Vollenweider, Peter; O'Reilly, Paul F.; Amin, Najaf; Bragg-Gresham, Jennifer L.; Teumer, Alexander; Glazer, Nicole L.; Launer, Lenore; Zhao, Jing Hua; Aulchenko, Yurii; Heath, Simon; Sõber, Siim; Parsa, Afshin; Luan, Jian'an; Arora, Pankaj; Dehghan, Abbas; Zhang, Feng; Lucas, Gavin; Hicks, Andrew A.; Jackson, Anne U.; Peden, John F.; Tanaka, Toshiko; Wild, Sarah H.; Rudan, Igor; Igl, Wilmar; Milaneschi, Yuri; Parker, Alex N.; Fava, Cristiano; Chambers, John C.; Kumari, Meena; JinGo, Min; van der Harst, Pim; Kao, Wen Hong Linda; Sjögren, Marketa; Vinay, D.G.; Alexander, Myriam; Tabara, Yasuharu; Shaw-Hawkins, Sue; Whincup, Peter H.; Liu, Yongmei; Shi, Gang; Kuusisto, Johanna; Seielstad, Mark; Sim, Xueling; Nguyen, Khanh-Dung Hoang; Lehtimäki, Terho; Matullo, Giuseppe; Wu, Ying; Gaunt, Tom R.; Charlotte Onland-Moret, N.; Cooper, Matthew N.; Platou, Carl G.P.; Org, Elin; Hardy, Rebecca; Dahgam, Santosh; Palmen, Jutta; Vitart, Veronique; Braund, Peter S.; Kuznetsova, Tatiana; Uiterwaal, Cuno S.P.M.; Campbell, Harry; Ludwig, Barbara; Tomaszewski, Maciej; Tzoulaki, Ioanna; Palmer, Nicholette D.; Aspelund, Thor; Garcia, Melissa; Chang, Yen-Pei C.; O'Connell, Jeffrey R.; Steinle, Nanette I.; Grobbee, Diederick E.; Arking, Dan E.; Hernandez, Dena; Najjar, Samer; McArdle, Wendy L.; Hadley, David; Brown, Morris J.; Connell, John M.; Hingorani, Aroon D.; Day, Ian N.M.; Lawlor, Debbie A.; Beilby, John P.; Lawrence, Robert W.; Clarke, Robert; Collins, Rory; Hopewell, Jemma C.; Ongen, Halit; Bis, Joshua C.; Kähönen, Mika; Viikari, Jorma; Adair, Linda S.; Lee, Nanette R.; Chen, Ming-Huei; Olden, Matthias; Pattaro, Cristian; Hoffman Bolton, Judith A.; Köttgen, Anna; Bergmann, Sven; Mooser, Vincent; Chaturvedi, Nish; Frayling, Timothy M.; Islam, Muhammad; Jafar, Tazeen H.; Erdmann, Jeanette; Kulkarni, Smita R.; Bornstein, Stefan R.; Grässler, Jürgen; Groop, Leif; Voight, Benjamin F.; Kettunen, Johannes; Howard, Philip; Taylor, Andrew; Guarrera, Simonetta; Ricceri, Fulvio; Emilsson, Valur; Plump, Andrew; Barroso, Inês; Khaw, Kay-Tee; Weder, Alan B.; Hunt, Steven C.; Bergman, Richard N.; Collins, Francis S.; Bonnycastle, Lori L.; Scott, Laura J.; Stringham, Heather M.; Peltonen, Leena; Perola, Markus; Vartiainen, Erkki; Brand, Stefan-Martin; Staessen, Jan A.; Wang, Thomas J.; Burton, Paul R.; SolerArtigas, Maria; Dong, Yanbin; Snieder, Harold; Wang, Xiaoling; Zhu, Haidong; Lohman, Kurt K.; Rudock, Megan E.; Heckbert, Susan R.; Smith, Nicholas L.; Wiggins, Kerri L.; Shriner, Daniel; Veldre, Gudrun; Viigimaa, Margus; Kinra, Sanjay; Prabhakaran, Dorairajan; Tripathy, Vikal; Langefeld, Carl D.; Rosengren, Annika; Thelle, Dag S.; MariaCorsi, Anna; Singleton, Andrew; Forrester, Terrence; Hilton, Gina; McKenzie, Colin A.; Salako, Tunde; Iwai, Naoharu; Kita, Yoshikuni; Ogihara, Toshio; Ohkubo, Takayoshi; Okamura, Tomonori; Ueshima, Hirotsugu; Umemura, Satoshi; Eyheramendy, Susana; Meitinger, Thomas; Wichmann, H.-Erich; Cho, Yoon Shin; Kim, Hyung-Lae; Lee, Jong-Young; Scott, James; Sehmi, Joban S.; Zhang, Weihua; Hedblad, Bo; Nilsson, Peter; Smith, George Davey; Wong, Andrew; Narisu, Narisu; Stančáková, Alena; Raffel, Leslie J.; Yao, Jie; Kathiresan, Sekar; O'Donnell, Chris; Schwartz, Steven M.; Arfan Ikram, M.; Longstreth, Will T.; Seshadri, Sudha; Shrine, Nick R.G.; Wain, Louise V.; Morken, Mario A.; Swift, Amy J.; Laitinen, Jaana; Prokopenko, Inga; Zitting, Paavo; Cooper, Jackie A.; Humphries, Steve E.; Danesh, John; Rasheed, Asif; Goel, Anuj; Hamsten, Anders; Watkins, Hugh; Bakker, Stephan J.L.; van Gilst, Wiek H.; Janipalli, Charles S.; Radha Mani, K.; Yajnik, Chittaranjan S.; Hofman, Albert; Mattace-Raso, Francesco U.S.; Oostra, Ben A.; Demirkan, Ayse; Isaacs, Aaron; Rivadeneira, Fernando; Lakatta, Edward G.; Orru, Marco; Scuteri, Angelo; Ala-Korpela, Mika; Kangas, Antti J.; Lyytikäinen, Leo-Pekka; Soininen, Pasi; Tukiainen, Taru; Würz, Peter; Twee-Hee Ong, Rick; Dörr, Marcus; Kroemer, Heyo K.; Völker, Uwe; Völzke, Henry; Galan, Pilar; Hercberg, Serge; Lathrop, Mark; Zelenika, Diana; Deloukas, Panos; Mangino, Massimo; Spector, Tim D.; Zhai, Guangju; Meschia, James F.; Nalls, Michael A.; Sharma, Pankaj; Terzic, Janos; Kranthi Kumar, M.J.; Denniff, Matthew; Zukowska-Szczechowska, Ewa; Wagenknecht, Lynne E.; Fowkes, Gerald R.; Charchar, Fadi J.; Schwarz, Peter E.H.; Hayward, Caroline; Guo, Xiuqing; Bots, Michiel L.; Brand, Eva; Samani, Nilesh J.; Polasek, Ozren; Talmud, Philippa J.; Nyberg, Fredrik; Kuh, Diana; Laan, Maris; Hveem, Kristian; Palmer, Lyle J.; van der Schouw, Yvonne T.; Casas, Juan P.; Mohlke, Karen L.; Vineis, Paolo; Raitakari, Olli; Wong, Tien Y.; Shyong Tai, E.; Laakso, Markku; Rao, Dabeeru C.; Harris, Tamara B.; Morris, Richard W.; Dominiczak, Anna F.; Kivimaki, Mika; Marmot, Michael G.; Miki, Tetsuro; Saleheen, Danish; Chandak, Giriraj R.; Coresh, Josef; Navis, Gerjan; Salomaa, Veikko; Han, Bok-Ghee; Kooner, Jaspal S.; Melander, Olle; Ridker, Paul M.; Bandinelli, Stefania; Gyllensten, Ulf B.; Wright, Alan F.; Wilson, James F.; Ferrucci, Luigi; Farrall, Martin; Tuomilehto, Jaakko; Pramstaller, Peter P.; Elosua, Roberto; Soranzo, Nicole; Sijbrands, Eric J.G.; Altshuler, David; Loos, Ruth J.F.; Shuldiner, Alan R.; Gieger, Christian; Meneton, Pierre; Uitterlinden, Andre G.; Wareham, Nicholas J.; Gudnason, Vilmundur; Rettig, Rainer; Uda, Manuela; Strachan, David P.; Witteman, Jacqueline C.M.; Hartikainen, Anna-Liisa; Beckmann, Jacques S.; Boerwinkle, Eric; Boehnke, Michael; Larson, Martin G.; Järvelin, Marjo-Riitta; Psaty, Bruce M.; Abecasis, Gonçalo R.; Elliott, Paul; van Duijn , Cornelia M.; Newton-Cheh, Christopher

    2011-01-01

    The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic variants at 13 loci that are associated with blood pressure. It is unknown if these variants confer susceptibility in people of African ancestry. Here, we examined genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs. Genotypes included genome-wide single-nucleotide polymorphism (SNP) data utilizing the Affymetrix 6.0 array with imputation to 2.5 million HapMap SNPs and candidate gene SNP data utilizing a 50K cardiovascular gene-centric array (ITMAT-Broad-CARe [IBC] array). For Affymetrix data, the strongest signal for DBP was rs10474346 (P= 3.6 × 10−8) located near GPR98 and ARRDC3. For SBP, the strongest signal was rs2258119 in C21orf91 (P= 4.7 × 10−8). The top IBC association for SBP was rs2012318 (P= 6.4 × 10−6) near SLC25A42 and for DBP was rs2523586 (P= 1.3 × 10−6) near HLA-B. None of the top variants replicated in additional AA (n = 11 882) or European-American (n = 69 899) cohorts. We replicated previously reported European-American blood pressure SNPs in our AA samples (SH2B3, P= 0.009; TBX3-TBX5, P= 0.03; and CSK-ULK3, P= 0.0004). These genetic loci represent the best evidence of genetic influences on SBP and DBP in AAs to date. More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexity. PMID:21378095

  16. Heart failure in African Americans: disparities can be overcome.

    PubMed

    Sharma, Alok; Colvin-Adams, Monica; Yancy, Clyde W

    2014-05-01

    African Americans are disproportionately affected by heart failure, with a high prevalence at an early age. Hypertension, diabetes, obesity, and chronic kidney disease are all common in African Americans and all predispose to heart failure. Neurohormonal imbalances, endothelial dysfunction, genetic polymorphisms, and socioeconomic factors also contribute. In general, the same evidence-based treatment guidelines that apply to white patients with heart failure also apply to African Americans. However, the combination of hydralazine and isosorbide dinitrate is advised specifically for African Americans.

  17. Common genetic influences on the timing of first use for alcohol, cigarettes, and cannabis in young African-American women

    PubMed Central

    Sartor, Carolyn E.; Agrawal, Arpana; Lynskey, Michael T.; Bucholz, Kathleen K.; Madden, Pamela A.F.; Heath, Andrew C.

    2011-01-01

    The risks associated with early age at initiation for alcohol, cigarette, and cannabis use are well documented, yet the timing of first use has rarely been studied in genetically informative frameworks, leaving the relative contributions of genetic and environmental factors to age at initiation largely unknown. The current study assessed overlap in heritable and environmental influences on the timing of initiation across these three substances in African-American women, using a sample of 462 female twins (100 monozygotic and 131 dizygotic pairs) from the Missouri Adolescent Female Twin Study. Mean age at the time of interview was 25.1 years. Ages at first use of alcohol, cigarettes, and cannabis were gathered in diagnostic interviews administered over the telephone. Standard genetic analyses were conducted with substance use initiation variables categorized as never, late, and early onset. Variance in the timing of first use was attributable in large part to genetic sources: 44% for alcohol, 62% for cigarettes, and 77% for cannabis. Genetic correlations across substances ranged from 0.25 to 0.70. Shared environmental influences were modest for alcohol (10%) and absent for cigarettes and cannabis. Findings contrast with reports from earlier studies based on primarily Caucasian samples, which have suggested a substantial role for shared environment on substance use initiation when measured as lifetime use. By characterizing onset as timing of first use, we may be tapping a separate construct. Differences in findings may also reflect a distinct etiological pathway for substance use initiation in African-American women that could not be detected in previous studies. PMID:19261395

  18. Genetic variants in one-carbon metabolism genes and breast cancer risk in European American and African American women.

    PubMed

    Gong, Zhihong; Yao, Song; Zirpoli, Gary; David Cheng, Ting-Yuan; Roberts, Michelle; Khoury, Thaer; Ciupak, Gregory; Davis, Warren; Pawlish, Karen; Jandorf, Lina; Bovbjerg, Dana H; Bandera, Elisa V; Ambrosone, Christine B

    2015-08-01

    Folate-mediated one-carbon metabolism plays critical roles in DNA synthesis, repair and DNA methylation. The impact of single nucleotide polymorphisms (SNPs) in folate-metabolizing enzymes has been investigated in risk of breast cancer among European or Asian populations, but not among women of African ancestry. We conducted a comprehensive analysis of SNPs in eleven genes involved in one-carbon metabolism and risk of breast cancer in 1,275 European-American (EA) and 1,299 African-American (AA) women who participated in the Women's Circle of Health Study. Allele frequencies varied significantly between EA and AA populations. A number of these SNPs, specifically in genes including MTR, MTRR, SHMT1, TYMS and SLC19A1, were associated with overall breast cancer risk, as well as risk by estrogen receptor (ER) status, in either EA or AA women. Associations appeared to be modified by dietary folate intake. Although single-SNP associations were not statistically significant after correcting for multiple comparisons, polygenetic score analyses revealed significant associations with breast cancer risk. Per unit increase of the risk score was associated with a modest 19 to 50% increase in risk of breast cancer overall, ER positive or ER negative cancer (all p < 0.0005) in EAs or AAs. In summary, our data suggest that one-carbon metabolizing gene polymorphisms could play a role in breast cancer and that may differ between EA and AA women.

  19. Brief report: Under-representation of African americans in autism genetic research: a rationale for inclusion of subjects representing diverse family structures.

    PubMed

    Hilton, Claudia L; Fitzgerald, Robert T; Jackson, Kelley M; Maxim, Rolanda A; Bosworth, Christopher C; Shattuck, Paul T; Geschwind, Daniel H; Constantino, John N

    2010-05-01

    African American children with autism are seriously under-represented in existing genetic registries and biomedical research studies of autism. We estimated the number of African American children with autism in the St. Louis region using CDC surveillance data and present the outcomes of a concerted effort to enroll approximately one-third of that population into either of two large national genetic autism registries. The results revealed that even after traditional barriers to research participation were addressed and all contacted families expressed a willingness to participate, 67% of the reachable families were disqualified from participation because of family structure alone. Comprehensive efforts-including expansion of eligibility to families of diverse structure-are warranted to facilitate the inclusion of African American children in biomedical research.

  20. Multiple sclerosis susceptibility alleles in African Americans

    PubMed Central

    Johnson, Britt A.; Wang, Joanne; Taylor, Elise M.; Caillier, Stacy J.; Herbert, Joseph; Khan, Omar A.; Cross, Anne H.; De Jager, Philip L.; Gourraud, Pierre-Antoine F.; Cree, Bruce C.A.; Hauser, Stephen L.; Oksenberg, Jorge R.

    2009-01-01

    Multiple sclerosis (MS) is an autoimmune demyelinating disease characterized by complex genetics and multifaceted gene-environment interactions. Compared to whites, African Americans have a lower risk for developing MS, but African Americans with MS have a greater risk of disability. These differences between African Americans and whites may represent differences in genetic susceptibility and/or environmental factors. SNPs from 12 candidate genes have recently been identified and validated with MS risk in white populations. We performed a replication study using 918 cases and 656 unrelated controls to test whether these candidate genes are also associated with MS risk in African Americans. CD6, CLEC16a, EVI5, GPC5, and TYK2 contained SNPs that are associated with MS risk in the African American dataset. EVI5 showed the strongest association outside the MHC (rs10735781, OR = 1.233, 95% CI = 1.06–1.43, P value = 0.006). In addition, RGS1 appears to affect age of onset whereas TNFRSF1A appears to be associated with disease progression. None of the tested variants showed results that were statistically in-consistent with the effects established in whites. The results are consistent with shared disease genetic mechanisms among individuals of European and African ancestry. PMID:19865102

  1. Sleep paralysis in African Americans with panic disorder.

    PubMed

    Paradis, Cheryl M; Friedman, Steven

    2005-03-01

    Studies have reported a wide range in lifetime prevalence of sleep paralysis (SP). This variation may stem from cultural factors, stressful life events and genetic differences in studied populations. We found that recurrent SP was more common among African-American participants, especially those with panic disorder. Recurrent SP was reported by 59% of African Americans with panic disorder, 7% of whites with panic disorder, 23% of African-American community volunteers and 6% of white community volunteers. Significantly more early life stressors were reported by African Americans than whites. Higher levels of psychosocial stressors, including poverty, racism and acculturation, may contribute to the higher rates of SP experienced by African Americans.

  2. Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network

    PubMed Central

    Malinowski, Jennifer R.; Denny, Joshua C.; Bielinski, Suzette J.; Basford, Melissa A.; Bradford, Yuki; Peissig, Peggy L.; Carrell, David; Crosslin, David R.; Pathak, Jyotishman; Rasmussen, Luke; Pacheco, Jennifer; Kho, Abel; Newton, Katherine M.; Li, Rongling; Kullo, Iftikhar J.; Chute, Christopher G.; Chisholm, Rex L.; Jarvik, Gail P.; Larson, Eric B.; McCarty, Catherine A.; Masys, Daniel R.; Roden, Dan M.; de Andrade, Mariza; Ritchie, Marylyn D.; Crawford, Dana C.

    2014-01-01

    Thyroid stimulating hormone (TSH) hormone levels are normally tightly regulated within an individual; thus, relatively small variations may indicate thyroid disease. Genome-wide association studies (GWAS) have identified variants in PDE8B and FOXE1 that are associated with TSH levels. However, prior studies lacked racial/ethnic diversity, limiting the generalization of these findings to individuals of non-European ethnicities. The Electronic Medical Records and Genomics (eMERGE) Network is a collaboration across institutions with biobanks linked to electronic medical records (EMRs). The eMERGE Network uses EMR-derived phenotypes to perform GWAS in diverse populations for a variety of phenotypes. In this report, we identified serum TSH levels from 4,501 European American and 351 African American euthyroid individuals in the eMERGE Network with existing GWAS data. Tests of association were performed using linear regression and adjusted for age, sex, body mass index (BMI), and principal components, assuming an additive genetic model. Our results replicate the known association of PDE8B with serum TSH levels in European Americans (rs2046045 p = 1.85×10−17, β = 0.09). FOXE1 variants, associated with hypothyroidism, were not genome-wide significant (rs10759944: p = 1.08×10−6, β = −0.05). No SNPs reached genome-wide significance in African Americans. However, multiple known associations with TSH levels in European ancestry were nominally significant in African Americans, including PDE8B (rs2046045 p = 0.03, β = −0.09), VEGFA (rs11755845 p = 0.01, β = −0.13), and NFIA (rs334699 p = 1.50×10−3, β = −0.17). We found little evidence that SNPs previously associated with other thyroid-related disorders were associated with serum TSH levels in this study. These results support the previously reported association between PDE8B and serum TSH levels in European Americans and emphasize the need for additional genetic

  3. Association of aldosterone synthase polymorphism (CYP11B2 -344T>C) and genetic ancestry with atrial fibrillation and serum aldosterone in African Americans with heart failure.

    PubMed

    Bress, Adam; Han, Jin; Patel, Shitalben R; Desai, Ankit A; Mansour, Ibrahim; Groo, Vicki; Progar, Kristin; Shah, Ebony; Stamos, Thomas D; Wing, Coady; Garcia, Joe G N; Kittles, Rick; Cavallari, Larisa H

    2013-01-01

    The objective of this study was to examine the extent to which aldosterone synthase genotype (CYP11B2) and genetic ancestry correlate with atrial fibrillation (AF) and serum aldosterone in African Americans with heart failure. Clinical data, echocardiographic measurements, and a genetic sample for determination of CYP11B2 -344T>C (rs1799998) genotype and genetic ancestry were collected from 194 self-reported African Americans with chronic, ambulatory heart failure. Genetic ancestry was determined using 105 autosomal ancestry informative markers. In a sub-set of patients (n = 126), serum was also collected for determination of circulating aldosterone. The CYP11B2 -344C allele frequency was 18% among the study population, and 19% of patients had AF. Multiple logistic regression revealed that the CYP11B2 -344CC genotype was a significant independent predictor of AF (OR 12.7, 95% CI 1.60-98.4, p = 0.0150, empirical p = 0.011) while holding multiple clinical factors, left atrial size, and percent European ancestry constant. Serum aldosterone was significantly higher among patients with AF (p = 0.036), whereas increased West African ancestry was inversely correlated with serum aldosterone (r = -0.19, p = 0.037). The CYP11B2 -344CC genotype was also overrepresented among patients with extreme aldosterone elevation (≥90th percentile, p = 0.0145). In this cohort of African Americans with chronic ambulatory heart failure, the CYP11B2 -344T>C genotype was a significant independent predictor of AF while holding clinical, echocardiographic predictors, and genetic ancestry constant. In addition, increased West African ancestry was associated with decreased serum aldosterone levels, potentially providing an explanation for the lower risk for AF observed among African Americans.

  4. IGF2R Genetic Variants, Circulating IGF2 Concentrations and Colon Cancer Risk in African Americans and Whites

    PubMed Central

    Hoyo, Cathrine; Murphy, Susan K.; Schildkraut, Joellen M.; Vidal, Adriana C.; Skaar, David; Millikan, Robert C.; Galanko, Joseph; Sandler, Robert S.; Jirtle, Randy; Keku, Temitope

    2012-01-01

    The Mannose 6 Phosphate/Insulin-like Growth Factor Receptor-2 (IGF2R) encodes a type-1 membrane protein that modulates availability of the potent mitogen, IGF2. We evaluated the associations between IGF2R non-synonymous genetic variants (c.5002G>A, Gly1619Arg(rs629849), and c.901C>G, Leu252Val(rs8191754)), circulating IGF2 levels, and colon cancer (CC) risk among African American and White participants enrolled in the North Carolina Colon Cancer Study (NCCCS). Generalized linear models were used to compare circulating levels of IGF2 among 298 African American and 518 White controls. Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association of IGF2R genetic variants and CC risk. Women homozygous for the IGF2R c.5002 G>A allele, had higher mean levels of circulating IGF2, 828 (SD=321) ng/ml compared to non-carriers, 595 (SD=217) ng/ml (p-value=0.01). This pattern was not apparent in individuals homozygous for the IGF2R c.901 C>G variant. Whites homozygous for the IGF2R c.901 C>G variant trended towards a higher risk of CC, OR=2.2 [95% CI(0.9–5.4)], whereas carrying the IGF2R c.5002 G>A variant was not associated with CC risk. Our findings support the hypothesis that being homozygous for the IGF2R c.5002 G>A modulates IGF2 circulating levels in a sex-specific manner, and while carrying the IGF2R c.901 C>G may increase cancer risk, the mechanism may not involve modulation of circulating IGF2. PMID:22377707

  5. Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.

    PubMed

    Ng, Maggie C Y; Shriner, Daniel; Chen, Brian H; Li, Jiang; Chen, Wei-Min; Guo, Xiuqing; Liu, Jiankang; Bielinski, Suzette J; Yanek, Lisa R; Nalls, Michael A; Comeau, Mary E; Rasmussen-Torvik, Laura J; Jensen, Richard A; Evans, Daniel S; Sun, Yan V; An, Ping; Patel, Sanjay R; Lu, Yingchang; Long, Jirong; Armstrong, Loren L; Wagenknecht, Lynne; Yang, Lingyao; Snively, Beverly M; Palmer, Nicholette D; Mudgal, Poorva; Langefeld, Carl D; Keene, Keith L; Freedman, Barry I; Mychaleckyj, Josyf C; Nayak, Uma; Raffel, Leslie J; Goodarzi, Mark O; Chen, Y-D Ida; Taylor, Herman A; Correa, Adolfo; Sims, Mario; Couper, David; Pankow, James S; Boerwinkle, Eric; Adeyemo, Adebowale; Doumatey, Ayo; Chen, Guanjie; Mathias, Rasika A; Vaidya, Dhananjay; Singleton, Andrew B; Zonderman, Alan B; Igo, Robert P; Sedor, John R; Kabagambe, Edmond K; Siscovick, David S; McKnight, Barbara; Rice, Kenneth; Liu, Yongmei; Hsueh, Wen-Chi; Zhao, Wei; Bielak, Lawrence F; Kraja, Aldi; Province, Michael A; Bottinger, Erwin P; Gottesman, Omri; Cai, Qiuyin; Zheng, Wei; Blot, William J; Lowe, William L; Pacheco, Jennifer A; Crawford, Dana C; Grundberg, Elin; Rich, Stephen S; Hayes, M Geoffrey; Shu, Xiao-Ou; Loos, Ruth J F; Borecki, Ingrid B; Peyser, Patricia A; Cummings, Steven R; Psaty, Bruce M; Fornage, Myriam; Iyengar, Sudha K; Evans, Michele K; Becker, Diane M; Kao, W H Linda; Wilson, James G; Rotter, Jerome I; Sale, Michèle M; Liu, Simin; Rotimi, Charles N; Bowden, Donald W

    2014-08-01

    Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies (GWAS) in individuals of European ancestry. In order to investigate the genetic architecture of T2D in African Americans, the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium examined 17 GWAS on T2D comprising 8,284 cases and 15,543 controls in African Americans in stage 1 analysis. Single nucleotide polymorphisms (SNPs) association analysis was conducted in each study under the additive model after adjustment for age, sex, study site, and principal components. Meta-analysis of approximately 2.6 million genotyped and imputed SNPs in all studies was conducted using an inverse variance-weighted fixed effect model. Replications were performed to follow up 21 loci in up to 6,061 cases and 5,483 controls in African Americans, and 8,130 cases and 38,987 controls of European ancestry. We identified three known loci (TCF7L2, HMGA2 and KCNQ1) and two novel loci (HLA-B and INS-IGF2) at genome-wide significance (4.15 × 10(-94)African Americans. Overall, this study identified two novel susceptibility loci for T2D in African Americans. A substantial number of previously reported loci are transferable to African Americans after accounting for linkage disequilibrium, enabling fine mapping of causal variants in trans-ethnic meta-analysis studies. PMID:25102180

  6. Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.

    PubMed

    Ng, Maggie C Y; Shriner, Daniel; Chen, Brian H; Li, Jiang; Chen, Wei-Min; Guo, Xiuqing; Liu, Jiankang; Bielinski, Suzette J; Yanek, Lisa R; Nalls, Michael A; Comeau, Mary E; Rasmussen-Torvik, Laura J; Jensen, Richard A; Evans, Daniel S; Sun, Yan V; An, Ping; Patel, Sanjay R; Lu, Yingchang; Long, Jirong; Armstrong, Loren L; Wagenknecht, Lynne; Yang, Lingyao; Snively, Beverly M; Palmer, Nicholette D; Mudgal, Poorva; Langefeld, Carl D; Keene, Keith L; Freedman, Barry I; Mychaleckyj, Josyf C; Nayak, Uma; Raffel, Leslie J; Goodarzi, Mark O; Chen, Y-D Ida; Taylor, Herman A; Correa, Adolfo; Sims, Mario; Couper, David; Pankow, James S; Boerwinkle, Eric; Adeyemo, Adebowale; Doumatey, Ayo; Chen, Guanjie; Mathias, Rasika A; Vaidya, Dhananjay; Singleton, Andrew B; Zonderman, Alan B; Igo, Robert P; Sedor, John R; Kabagambe, Edmond K; Siscovick, David S; McKnight, Barbara; Rice, Kenneth; Liu, Yongmei; Hsueh, Wen-Chi; Zhao, Wei; Bielak, Lawrence F; Kraja, Aldi; Province, Michael A; Bottinger, Erwin P; Gottesman, Omri; Cai, Qiuyin; Zheng, Wei; Blot, William J; Lowe, William L; Pacheco, Jennifer A; Crawford, Dana C; Grundberg, Elin; Rich, Stephen S; Hayes, M Geoffrey; Shu, Xiao-Ou; Loos, Ruth J F; Borecki, Ingrid B; Peyser, Patricia A; Cummings, Steven R; Psaty, Bruce M; Fornage, Myriam; Iyengar, Sudha K; Evans, Michele K; Becker, Diane M; Kao, W H Linda; Wilson, James G; Rotter, Jerome I; Sale, Michèle M; Liu, Simin; Rotimi, Charles N; Bowden, Donald W

    2014-08-01

    Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies (GWAS) in individuals of European ancestry. In order to investigate the genetic architecture of T2D in African Americans, the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium examined 17 GWAS on T2D comprising 8,284 cases and 15,543 controls in African Americans in stage 1 analysis. Single nucleotide polymorphisms (SNPs) association analysis was conducted in each study under the additive model after adjustment for age, sex, study site, and principal components. Meta-analysis of approximately 2.6 million genotyped and imputed SNPs in all studies was conducted using an inverse variance-weighted fixed effect model. Replications were performed to follow up 21 loci in up to 6,061 cases and 5,483 controls in African Americans, and 8,130 cases and 38,987 controls of European ancestry. We identified three known loci (TCF7L2, HMGA2 and KCNQ1) and two novel loci (HLA-B and INS-IGF2) at genome-wide significance (4.15 × 10(-94)African Americans. Overall, this study identified two novel susceptibility loci for T2D in African Americans. A substantial number of previously reported loci are transferable to African Americans after accounting for linkage disequilibrium, enabling fine mapping of causal variants in trans-ethnic meta-analysis studies.

  7. Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes

    PubMed Central

    Chen, Brian H.; Li, Jiang; Chen, Wei-Min; Guo, Xiuqing; Liu, Jiankang; Bielinski, Suzette J.; Yanek, Lisa R.; Nalls, Michael A.; Comeau, Mary E.; Rasmussen-Torvik, Laura J.; Jensen, Richard A.; Evans, Daniel S.; Sun, Yan V.; An, Ping; Patel, Sanjay R.; Lu, Yingchang; Long, Jirong; Armstrong, Loren L.; Wagenknecht, Lynne; Yang, Lingyao; Snively, Beverly M.; Palmer, Nicholette D.; Mudgal, Poorva; Langefeld, Carl D.; Keene, Keith L.; Freedman, Barry I.; Mychaleckyj, Josyf C.; Nayak, Uma; Raffel, Leslie J.; Goodarzi, Mark O.; Chen, Y-D Ida; Taylor, Herman A.; Correa, Adolfo; Sims, Mario; Couper, David; Pankow, James S.; Boerwinkle, Eric; Adeyemo, Adebowale; Doumatey, Ayo; Chen, Guanjie; Mathias, Rasika A.; Vaidya, Dhananjay; Singleton, Andrew B.; Zonderman, Alan B.; Igo, Robert P.; Sedor, John R.; Kabagambe, Edmond K.; Siscovick, David S.; McKnight, Barbara; Rice, Kenneth; Liu, Yongmei; Hsueh, Wen-Chi; Zhao, Wei; Bielak, Lawrence F.; Kraja, Aldi; Province, Michael A.; Bottinger, Erwin P.; Gottesman, Omri; Cai, Qiuyin; Zheng, Wei; Blot, William J.; Lowe, William L.; Pacheco, Jennifer A.; Crawford, Dana C.; Grundberg, Elin; Rich, Stephen S.; Hayes, M. Geoffrey; Shu, Xiao-Ou; Loos, Ruth J. F.; Borecki, Ingrid B.; Peyser, Patricia A.; Cummings, Steven R.; Psaty, Bruce M.; Fornage, Myriam; Iyengar, Sudha K.; Evans, Michele K.; Becker, Diane M.; Kao, W. H. Linda; Wilson, James G.; Rotter, Jerome I.; Sale, Michèle M.; Liu, Simin; Rotimi, Charles N.; Bowden, Donald W.

    2014-01-01

    Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies (GWAS) in individuals of European ancestry. In order to investigate the genetic architecture of T2D in African Americans, the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium examined 17 GWAS on T2D comprising 8,284 cases and 15,543 controls in African Americans in stage 1 analysis. Single nucleotide polymorphisms (SNPs) association analysis was conducted in each study under the additive model after adjustment for age, sex, study site, and principal components. Meta-analysis of approximately 2.6 million genotyped and imputed SNPs in all studies was conducted using an inverse variance-weighted fixed effect model. Replications were performed to follow up 21 loci in up to 6,061 cases and 5,483 controls in African Americans, and 8,130 cases and 38,987 controls of European ancestry. We identified three known loci (TCF7L2, HMGA2 and KCNQ1) and two novel loci (HLA-B and INS-IGF2) at genome-wide significance (4.15×10−94African Americans. Overall, this study identified two novel susceptibility loci for T2D in African Americans. A substantial number of previously reported loci are transferable to African Americans after accounting for linkage disequilibrium, enabling fine mapping of causal variants in trans-ethnic meta-analysis studies. PMID:25102180

  8. African American Administrators and Staff

    ERIC Educational Resources Information Center

    Wright, Dianne; Taylor, Janice D.; Burrell, Charlotte; Stewart, Gregory

    2006-01-01

    This article explores the issues of African American participation in the administrative ranks of the academy. The authors find that African Americans tend to hold positions that are marginal in academic organizations, lacking power and influence, and that not much has changed over recent decades. Forces influencing this condition are explored,…

  9. African-American Children's Literature.

    ERIC Educational Resources Information Center

    Kline, Lucinda

    This paper examines the history of African American children's literature, the present-day status of it, and ventures predictions about its future. The paper also considers the historic and social factors of the debate about whether an author who is not African American can write a book that will/should be accepted in this category of children's…

  10. African-American Sacred Music.

    ERIC Educational Resources Information Center

    Bailey, A. Peter

    1991-01-01

    The history of African-American sacred music is traced from the time of slavery to the present interest in gospel music. The religious music of African Americans is geared toward liberation themes. It is important that this music does not dilute its power through cross-over with other music forms. (SLD)

  11. Cancer statistics for African Americans.

    PubMed

    Ghafoor, Asma; Jemal, Ahmedin; Cokkinides, Vilma; Cardinez, Cheryll; Murray, Taylor; Samuels, Alicia; Thun, Michael J

    2002-01-01

    The American Cancer Society provides estimates on the number of new cancer cases and deaths, and compiles health statistics on African Americans in a biennial publication, Cancer Facts and Figures for African Americans. The compiled statistics include cancer incidence, mortality, survival, and lifestyle behaviors using the most recent data on incidence and survival from the National Cancer Institute's (NCI) Surveillance, Epidemiology, and End Results (SEER) program, mortality data from the National Center for Health Statistics (NCHS), and behavioral information from the Behavior Risk Factor Surveillance System (BRFSS), Youth Risk Behavior Surveillance System (YRBSS), and National Health Interview Survey (NHIS). It is estimated that 132,700 new cases of cancer and 63,100 deaths will occur among African Americans in the year 2003. Although African Americans have experienced higher incidence and mortality rates of cancer than whites for many years, incidence rates have declined by 2.7 percent per year in African-American males since 1992, while stabilizing in African-American females. During the same period, death rates declined by 2.1 percent and 0.4 percent per year among African-American males and females, respectively. The decrease in both incidence and death rates from cancer among African-American males was the largest of any racial or ethnic group. Nonetheless, African Americans still carry the highest cancer burden among US racial and ethnic groups. Most cancers detectable by screening are diagnosed at a later stage and survival rates are lower within each stage of disease in African Americans than in whites. The extent to which these disparities reflect unequal access to health care versus other factors is an active area of research.

  12. Genetic variation of the whole ICAM4 gene in Caucasians and African Americans

    PubMed Central

    Srivastava, Kshitij; Almarry, Noorah Salman; Flegel, Willy A.

    2014-01-01

    Background Landsteiner-Wiener (LW) is the human blood group system no. 16, which comprises 2 antithetical antigens, LWa and LWb and the high prevalence antigen LWab. LW is encoded by the Intracellular Adhesion Molecule 4 (ICAM4) gene. The ICAM4 protein is part of the Rhesus complex in the red cell membrane and is involved in cell-cell adhesion. Methods We developed a method to sequence the whole 1.9 kb ICAM4 gene from genomic DNA in 1 amplicon. We determined the nucleotide sequence of exons 1 to 3, the 2 introns and 402 bp 5′-UTR and 347 bp 3′-UTR in 97 Caucasian and 91 African American individuals. Results Seven variant ICAM4 alleles were found, distinct from the wild type ICAM4 allele (GenBank KF712272), known as LW*05 and encoding LWa. An effect of the LWa/LWb amino acid substitution on the protein structure was predicted by 2 of the 3 computational modeling programs used. Conclusions We describe a practical approach for sequencing and determining the ICAM4 alleles using genomic DNA. LW*05 is the ancestral allele, which had also been observed in a Neandertal sample. All 7 variant alleles are immediate derivatives of the prevalent LW*05 and caused by 1 single nucleotide polymorphism (SNP) in each allele. Our data were consistent with the NHLBI GO Exome Sequencing Project (ESP) and the dbSNP databases, as all SNPs had been observed before. Our study has the advantage over the other databases in that it adds haplotype (allele) information for the ICAM4 gene, clinically relevant in the field of transfusion medicine. PMID:24673173

  13. Genetic variations in vitamin D-related pathways and breast cancer risk in African American women in the AMBER consortium.

    PubMed

    Yao, Song; Haddad, Stephen A; Hu, Qiang; Liu, Song; Lunetta, Kathryn L; Ruiz-Narvaez, Edward A; Hong, Chi-Chen; Zhu, Qianqian; Sucheston-Campbell, Lara; Cheng, Ting-Yuan David; Bensen, Jeannette T; Johnson, Candace S; Trump, Donald L; Haiman, Christopher A; Olshan, Andrew F; Palmer, Julie R; Ambrosone, Christine B

    2016-05-01

    Studies of genetic variations in vitamin D-related pathways and breast cancer risk have been conducted mostly in populations of European ancestry, and only sparsely in African Americans (AA), who are known for a high prevalence of vitamin D deficiency. We analyzed 24,445 germline variants in 63 genes from vitamin D-related pathways in the African American Breast Cancer Epidemiology and Risk (AMBER) consortium, including 3,663 breast cancer cases and 4,687 controls. Odds ratios (OR) were derived from logistic regression models for overall breast cancer, by estrogen receptor (ER) status (1,983 ER positive and 1,098 ER negative), and for case-only analyses of ER status. None of the three vitamin D-related pathways were associated with breast cancer risk overall or by ER status. Gene-level analyses identified associations with risk for several genes at a nominal p ≤ 0.05, particularly for ER- breast cancer, including rs4647707 in DDB2. In case-only analyses, vitamin D metabolism and signaling pathways were associated with ER- cancer (pathway-level p = 0.02), driven by a single gene CASR (gene-level p = 0.001). The top SNP in CASR was rs112594756 (p = 7 × 10(-5), gene-wide corrected p = 0.01), followed by a second signal from a nearby SNP rs6799828 (p = 1 × 10(-4), corrected p = 0.03). In summary, several variants in vitamin D pathways were associated with breast cancer risk in AA women. In addition, CASR may be related to tumor ER status, supporting a role of vitamin D or calcium in modifying breast cancer phenotypes. PMID:26650177

  14. Genetic variations in vitamin D-related pathways and breast cancer risk in African American women in the AMBER consortium.

    PubMed

    Yao, Song; Haddad, Stephen A; Hu, Qiang; Liu, Song; Lunetta, Kathryn L; Ruiz-Narvaez, Edward A; Hong, Chi-Chen; Zhu, Qianqian; Sucheston-Campbell, Lara; Cheng, Ting-Yuan David; Bensen, Jeannette T; Johnson, Candace S; Trump, Donald L; Haiman, Christopher A; Olshan, Andrew F; Palmer, Julie R; Ambrosone, Christine B

    2016-05-01

    Studies of genetic variations in vitamin D-related pathways and breast cancer risk have been conducted mostly in populations of European ancestry, and only sparsely in African Americans (AA), who are known for a high prevalence of vitamin D deficiency. We analyzed 24,445 germline variants in 63 genes from vitamin D-related pathways in the African American Breast Cancer Epidemiology and Risk (AMBER) consortium, including 3,663 breast cancer cases and 4,687 controls. Odds ratios (OR) were derived from logistic regression models for overall breast cancer, by estrogen receptor (ER) status (1,983 ER positive and 1,098 ER negative), and for case-only analyses of ER status. None of the three vitamin D-related pathways were associated with breast cancer risk overall or by ER status. Gene-level analyses identified associations with risk for several genes at a nominal p ≤ 0.05, particularly for ER- breast cancer, including rs4647707 in DDB2. In case-only analyses, vitamin D metabolism and signaling pathways were associated with ER- cancer (pathway-level p = 0.02), driven by a single gene CASR (gene-level p = 0.001). The top SNP in CASR was rs112594756 (p = 7 × 10(-5), gene-wide corrected p = 0.01), followed by a second signal from a nearby SNP rs6799828 (p = 1 × 10(-4), corrected p = 0.03). In summary, several variants in vitamin D pathways were associated with breast cancer risk in AA women. In addition, CASR may be related to tumor ER status, supporting a role of vitamin D or calcium in modifying breast cancer phenotypes.

  15. Lung cancer risk in relation to genetic polymorphisms of microsomal epoxide hydrolase among African-Americans and Caucasians in Los Angeles County.

    PubMed

    London, S J; Smart, J; Daly, A K

    2000-05-01

    Microsomal epoxide hydrolase participates in the metabolism of benzo[a]pyrene, an important carcinogen in tobacco smoke. Two relatively common polymorphisms of the microsomal epoxide hydrolase gene that influence enzyme activity have been described. An association between genetic variation in microsomal epoxide hydrolase and lung cancer risk has been reported in one of two studies of Caucasians. We examined the relation between these two polymorphisms and lung cancer risk among 337 incident cases and 700 population controls of African-American and Caucasian ethnicity enrolled in a case-control study in Los Angeles County. African-Americans, homozygous for the exon 3 variant allele conferring reduced activity, were at decreased risk of lung cancer (odds ratio (OR)=0.08, 95% CI 0.01-0.62). When data from both the exon 3 and exon 4 polymorphisms were combined into indices of predicted microsomal epoxide hydrolase activity, a decreased risk was seen among African-American subjects with very low predicted activity OR=0.10 (95% CI 0.01-0.83). No comparable association was seen among Caucasians. Although the three published results for Caucasians are somewhat variable, the association among African-Americans in these data provides some support for the hypothesis that genetically reduced microsomal epoxide hydrolase activity may be protective against lung cancer.

  16. Common genetic variation near the connexin-43 gene is associated with resting heart rate in African Americans: A genome-wide association study of 13,372 participants

    PubMed Central

    Deo, R.; Nalls, M.A.; Avery, C.L.; Smith, J.G.; Evans, D.S.; Keller, M.F.; Butler, A.M.; Buxbaum, S.G.; Li, G.; Quibrera, P. Miguel; Smith, E.N.; Tanaka, T.; Akylbekova, E.L.; Alonso, A.; Arking, D.E.; Benjamin, E.J.; Berenson, G.S.; Bis, J.C.; Chen, L.Y.; Chen, W.; Cummings, S.R.; Ellinor, P.T.; Evans, M.K.; Ferrucci, L.; Fox, E.R.; Heckbert, S.R.; Heiss, G.; Hsueh, W.C.; Kerr, K.F.; Limacher, M.C.; Liu, Y.; Lubitz, S.A.; Magnani, J.W.; Mehra, R.; Marcus, G.M.; Murray, S.S.; Newman, A.B.; Njajou, O.; North, K.E.; Paltoo, D.N.; Psaty, B.M.; Redline, S.S.; Reiner, A.P.; Robinson, J.G.; Rotter, J.I.; Samdarshi, T.E.; Schnabel, R.B.; Schork, N.J.; Singleton, A.B.; Siscovick, D.; Soliman, E.Z.; Sotoodehnia, N.; Srinivasan, S.R.; Taylor, H.A.; Trevisan, M.; Zhang, Z.; Zonderman, A.B.; Newton-Cheh, C.; Whitsel, E.A.

    2013-01-01

    BACKGROUND Genome-wide association studies have identified several genetic loci associated with variation in resting heart rate in European and Asian populations. No study has evaluated genetic variants associated with heart rate in African Americans. OBJECTIVE To identify novel genetic variants associated with resting heart rate in African Americans. METHODS Ten cohort studies participating in the Candidate-gene Association Resource and Continental Origins and Genetic Epidemiology Network consortia performed genome-wide genotyping of single nucleotide polymorphisms (SNPs) and imputed 2,954,965 SNPs using HapMap YRI and CEU panels in 13,372 participants of African ancestry. Each study measured the RR interval (ms) from 10-second resting 12-lead electrocardiograms and estimated RR-SNP associations using covariate-adjusted linear regression. Random-effects meta-analysis was used to combine cohort-specific measures of association and identify genome-wide significant loci (P ≤ 2.5 × 10−8). RESULTS Fourteen SNPs on chromosome 6q22 exceeded the genome-wide significance threshold. The most significant association was for rs9320841 (+13 ms per minor allele; P = 4.98 × 10−15). This SNP was approximately 350 kb downstream of GJA1, a locus previously identified as harboring SNPs associated with heart rate in Europeans. Adjustment for rs9320841 also attenuated the association between the remaining 13 SNPs in this region and heart rate. In addition, SNPs in MYH6, which have been identified in European genome-wide association study, were associated with similar changes in the resting heart rate as this population of African Americans. CONCLUSIONS An intergenic region downstream of GJA1 (the gene encoding connexin 43, the major protein of the human myocardial gap junction) and an intragenic region within MYH6 are associated with variation in resting heart rate in African Americans as well as in populations of European and Asian origin. PMID:23183192

  17. Exploring the genetic architecture of alcohol dependence in African-Americans via analysis of a genomewide set of common variants.

    PubMed

    Yang, Can; Li, Cong; Kranzler, Henry R; Farrer, Lindsay A; Zhao, Hongyu; Gelernter, Joel

    2014-05-01

    Alcohol dependence (AD) is a complex psychiatric disorder that affects about 12.5 % of US adults. Genetic factors play a major role in the development of AD. We conducted a genomewide association study in 2,875 African-Americans including 1,719 AD cases and 1,156 controls. We used the Illumina Omni 1-Quad microarray, which yielded 769,498 single-nucleotide polymorphisms (SNPs) after quality control. To explore the genetic architecture of AD, we estimated the variance that could be explained by all SNPs and subsets of SNPs using two different approaches to genome partitioning. We found that 23.9 % (s.e. 9.3 %) of the phenotypic variance could be explained by using all of the common SNPs on the array. We also found a significant linear relationship between the proportion of the top SNPs used and the phenotypic variance explained by them. Based on genome partitioning of common variants, we also observed a significant linear relationship between the variance explained by a chromosome and its length. Chromosome 4, known to contain several AD risk genes, accounted for excess risk in proportion to its length. By functional partitioning, we found that the genetic variants within 20 kb of genes explained 17.5 % (s.e. 11.4 %) of the phenotypic variance. Our findings are consistent with the generally accepted view that AD is a highly polygenic trait, i.e., the genetic risk in AD appears to be conferred by multiple variants, each of which may have a small or moderate effect.

  18. Successfully Educating Our African-American Students

    ERIC Educational Resources Information Center

    Moncree-Moffett, Kareem

    2013-01-01

    The purpose of this empirical study was to explore the lived experiences of African American retired female teachers who have prior experience with educating urban African American students in public schools. Also explored are the experiences of active African American female teachers of urban African American students and comparisons are…

  19. An African-American family with dystonia.

    PubMed

    Puschmann, Andreas; Xiao, Jianfeng; Bastian, Robert W; Searcy, Jill A; LeDoux, Mark S; Wszolek, Zbigniew K

    2011-08-01

    The genetic cause of late-onset focal and segmental dystonia remains unknown in most individuals. Recently, mutations in Thanatos-associated protein domain containing, apoptosis associated protein 1 (THAP1) have been described in DYT6 dystonia and associated with some cases of familial and sporadic late-onset dystonia in Caucasians. We are not aware of any previous descriptions of familial dystonia in African-Americans or reports of THAP1 mutations in African-Americans. Herein, we characterize an African-American (AA) kindred with late-onset primary dystonia, clinically and genetically. The clinical phenotype included cervical, laryngeal and hand-forearm dystonia. Symptoms were severe and disabling for several family members, whereas others only displayed mild signs. There were no accompanying motor or cognitive signs. In this kindred, age of onset ranged from 45 to 50 years and onset was frequently sudden, with symptoms developing within weeks or months. DYT1 was excluded as the cause of dystonia in this kindred. The entire genomic region of THAP1, including non-coding regions, was sequenced. We identified 13 sequence variants in THAP1, although none co-segregated with dystonia. A novel THAP1 variant (c.-237-3G>T/A) was found in 3/84 AA dystonia patient alleles and 3/212 AA control alleles, but not in 5870 Caucasian alleles. In summary, although previously unreported, familial primary dystonia does occur in African-Americans. Genetic analysis of the entire genomic region of THAP1 revealed a novel variant that was specific for African-Americans. Therefore, genetic testing for dystonia and future studies of candidate genes must take genetic background into consideration. PMID:21601506

  20. An African-American Family with Dystonia

    PubMed Central

    Puschmann, Andreas; Xiao, Jianfeng; Bastian, Robert W.; Searcy, Jill A.; LeDoux, Mark S.; Wszolek, Zbigniew K.

    2011-01-01

    The genetic cause of late-onset focal and segmental dystonia remains unknown in most individuals. Recently, mutations in Thanatos-associated protein domain containing, apoptosis associated protein 1 (THAP1) have been described in DYT6 dystonia and associated with some cases of familial and sporadic late-onset dystonia in Caucasians. We are not aware of any previous descriptions of familial dystonia in African Americans or reports of THAP1 mutations in African Americans. Herein, we characterize an African-American (AA) kindred with late-onset primary dystonia, clinically and genetically. The clinical phenotype included cervical, laryngeal and hand-forearm dystonia. Symptoms were severe and disabling for several family members, whereas others only displayed mild signs. There were no accompanying motor or cognitive signs. In this kindred, age of onset ranged from 45 to 50 years and onset was frequently sudden, with symptoms developing within weeks or months. DYT1 was excluded as the cause of dystonia in this kindred. The entire genomic region of THAP1, including non-coding regions, was sequenced. We identified 13 sequence variants in THAP1, although none co-segregated with dystonia. A novel THAP1 variant (c.-237-3G>T/A) was found in 3/84 AA dystonia patient alleles and 3/212 AA control alleles, but not in 5,870 Caucasian alleles. In summary, although previously unreported, familial primary dystonia does occur in African Americans. Genetic analysis of the entire genomic region of THAP1 revealed a novel variant that was specific for African Americans. Therefore, genetic testing for dystonia and future studies of candidate genes must take genetic background into consideration. PMID:21601506

  1. Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT).

    PubMed

    Reiner, Alexander P; Lettre, Guillaume; Nalls, Michael A; Ganesh, Santhi K; Mathias, Rasika; Austin, Melissa A; Dean, Eric; Arepalli, Sampath; Britton, Angela; Chen, Zhao; Couper, David; Curb, J David; Eaton, Charles B; Fornage, Myriam; Grant, Struan F A; Harris, Tamara B; Hernandez, Dena; Kamatini, Naoyuki; Keating, Brendan J; Kubo, Michiaki; LaCroix, Andrea; Lange, Leslie A; Liu, Simin; Lohman, Kurt; Meng, Yan; Mohler, Emile R; Musani, Solomon; Nakamura, Yusuke; O'Donnell, Christopher J; Okada, Yukinori; Palmer, Cameron D; Papanicolaou, George J; Patel, Kushang V; Singleton, Andrew B; Takahashi, Atsushi; Tang, Hua; Taylor, Herman A; Taylor, Kent; Thomson, Cynthia; Yanek, Lisa R; Yang, Lingyao; Ziv, Elad; Zonderman, Alan B; Folsom, Aaron R; Evans, Michele K; Liu, Yongmei; Becker, Diane M; Snively, Beverly M; Wilson, James G

    2011-06-01

    Total white blood cell (WBC) and neutrophil counts are lower among individuals of African descent due to the common African-derived "null" variant of the Duffy Antigen Receptor for Chemokines (DARC) gene. Additional common genetic polymorphisms were recently associated with total WBC and WBC sub-type levels in European and Japanese populations. No additional loci that account for WBC variability have been identified in African Americans. In order to address this, we performed a large genome-wide association study (GWAS) of total WBC and cell subtype counts in 16,388 African-American participants from 7 population-based cohorts available in the Continental Origins and Genetic Epidemiology Network. In addition to the DARC locus on chromosome 1q23, we identified two other regions (chromosomes 4q13 and 16q22) associated with WBC in African Americans (P<2.5×10(-8)). The lead SNP (rs9131) on chromosome 4q13 is located in the CXCL2 gene, which encodes a chemotactic cytokine for polymorphonuclear leukocytes. Independent evidence of the novel CXCL2 association with WBC was present in 3,551 Hispanic Americans, 14,767 Japanese, and 19,509 European Americans. The index SNP (rs12149261) on chromosome 16q22 associated with WBC count is located in a large inter-chromosomal segmental duplication encompassing part of the hydrocephalus inducing homolog (HYDIN) gene. We demonstrate that the chromosome 16q22 association finding is most likely due to a genotyping artifact as a consequence of sequence similarity between duplicated regions on chromosomes 16q22 and 1q21. Among the WBC loci recently identified in European or Japanese populations, replication was observed in our African-American meta-analysis for rs445 of CDK6 on chromosome 7q21 and rs4065321 of PSMD3-CSF3 region on chromosome 17q21. In summary, the CXCL2, CDK6, and PSMD3-CSF3 regions are associated with WBC count in African American and other populations. We also demonstrate that large inter-chromosomal duplications can

  2. Hepatitis C in African Americans.

    PubMed

    Saab, Sammy; Jackson, Christian; Nieto, Jose; Francois, Fritz

    2014-10-01

    The care of hepatitis C virus (HCV) in African Americans represents an opportunity to address a major health disparity in medicine. In all facets of HCV infection, African Americans are inexplicably affected, including in the prevalence of the virus, which is higher among them compared with most of the racial and ethnic groups. Ironically, although fibrosis rates may be slow, hepatocellular carcinoma and mortality rates appear to be higher among African Americans. Sustained viral response (SVR) rates have historically significantly trailed behind Caucasians. The reasons for this gap in SVR are related to both viral and host factors. Moreover, low enrollment rates in clinical trials hamper the study of the efficacy of anti-viral therapy. Nevertheless, the gap in SVR between African Americans and Caucasians may be narrowing with the use of direct-acting agents. Gastroenterologists, hepatologists, primary care physicians, and other health-care providers need to address modifiable risk factors that affect the natural history, as well as treatment outcomes, for HCV among African Americans. Efforts need to be made to improve awareness among health-care providers to address the differences in screening and referral patterns for African Americans.

  3. Novel recurrently mutated genes in African American colon cancers

    PubMed Central

    Guda, Kishore; Veigl, Martina L.; Varadan, Vinay; Nosrati, Arman; Ravi, Lakshmeswari; Lutterbaugh, James; Beard, Lydia; Willson, James K. V.; Sedwick, W. David; Wang, Zhenghe John; Molyneaux, Neil; Miron, Alexander; Adams, Mark D.; Elston, Robert C.; Markowitz, Sanford D.; Willis, Joseph E.

    2015-01-01

    We used whole-exome and targeted sequencing to characterize somatic mutations in 103 colorectal cancers (CRC) from African Americans, identifying 20 new genes as significantly mutated in CRC. Resequencing 129 Caucasian derived CRCs confirmed a 15-gene set as a preferential target for mutations in African American CRCs. Two predominant genes, ephrin type A receptor 6 (EPHA6) and folliculin (FLCN), with mutations exclusive to African American CRCs, are by genetic and biological criteria highly likely African American CRC driver genes. These previously unsuspected differences in the mutational landscapes of CRCs arising among individuals of different ethnicities have potential to impact on broader disparities in cancer behaviors. PMID:25583493

  4. Novel recurrently mutated genes in African American colon cancers.

    PubMed

    Guda, Kishore; Veigl, Martina L; Varadan, Vinay; Nosrati, Arman; Ravi, Lakshmeswari; Lutterbaugh, James; Beard, Lydia; Willson, James K V; Sedwick, W David; Wang, Zhenghe John; Molyneaux, Neil; Miron, Alexander; Adams, Mark D; Elston, Robert C; Markowitz, Sanford D; Willis, Joseph E

    2015-01-27

    We used whole-exome and targeted sequencing to characterize somatic mutations in 103 colorectal cancers (CRC) from African Americans, identifying 20 new genes as significantly mutated in CRC. Resequencing 129 Caucasian derived CRCs confirmed a 15-gene set as a preferential target for mutations in African American CRCs. Two predominant genes, ephrin type A receptor 6 (EPHA6) and folliculin (FLCN), with mutations exclusive to African American CRCs, are by genetic and biological criteria highly likely African American CRC driver genes. These previously unsuspected differences in the mutational landscapes of CRCs arising among individuals of different ethnicities have potential to impact on broader disparities in cancer behaviors. PMID:25583493

  5. Genetic variations in the Hippo signaling pathway and breast cancer risk in African American women in the AMBER Consortium.

    PubMed

    Zhang, Jianmin; Yao, Song; Hu, Qiang; Zhu, Qianqian; Liu, Song; Lunetta, Kathryn L; Haddad, Stephen A; Yang, Nuo; Shen, He; Hong, Chi-Chen; Sucheston-Campbell, Lara; Ruiz-Narvaez, Edward A; Bensen, Jeannette T; Troester, Melissa A; Bandera, Elisa V; Rosenberg, Lynn; Haiman, Christopher A; Olshan, Andrew F; Palmer, Julie R; Ambrosone, Christine B

    2016-10-01

    The Hippo signaling pathway regulates cellular proliferation and survival, thus exerting profound effects on normal cell fate and tumorigenesis. Dysfunction of the Hippo pathway components has been linked with breast cancer stem cell regulation, as well as breast tumor progression and metastasis. TAZ, a key component of the Hippo pathway, is highly expressed in triple negative breast cancer; however, the associations of genetic variations in this important pathway with breast cancer risk remain largely unexplored. Here, we analyzed 8309 germline variants in 15 genes from the Hippo pathway with a total of 3663 cases and 4687 controls from the African American Breast Cancer Epidemiology and Risk Consortium. Odds ratios (ORs) were estimated using logistic regression for overall breast cancer, by estrogen receptor (ER) status (1983 ER positive and 1098 ER negative), and for case-only analyses by ER status. The Hippo signaling pathway was significantly associated with ER-negative breast cancer (pathway level P = 0.02). Gene-based analyses revealed that CDH1 was responsible for the pathway association (P < 0.01), with rs4783673 in CDH1 statistically significant after gene-level adjustment for multiple comparisons (P = 9.2×10(-5), corrected P = 0.02). rs142697907 in PTPN14 was associated with ER-positive breast cancer and rs2456773 in CDK1 with ER-negativity in case-only analysis after gene-level correction for multiple comparisons (corrected P < 0.05). In conclusion, common genetic variations in the Hippo signaling pathway may contribute to both ER-negative and ER+ breast cancer risk in AA women.

  6. Genetic meta-analysis of 15,901 African Americans identifies variation in EXOC3L1 is associated with HDL concentration.

    PubMed

    Lanktree, Matthew B; Elbers, Clara C; Li, Yun; Zhang, Guosheng; Duan, Qing; Karczewski, Konrad J; Guo, Yiran; Tragante, Vinicius; North, Kari E; Cushman, Mary; Asselbergs, Folkert W; Wilson, James G; Lange, Leslie A; Drenos, Fotios; Reiner, Alex P; Barnes, Michael R; Keating, Brendan J

    2015-09-01

    Meta-analyses of European populations has successfully identified genetic variants in over 150 loci associated with lipid levels, but results from additional ethnicities remain limited. Previously, we reported two novel lipid loci identified in a sample of 7,657 African Americans using a gene-centric array including 50,000 SNPs in 2,100 candidate genes. Initial discovery and follow-up of signals with P < 10(-5) in additional African American samples confirmed CD36 and ICAM1. Using an additional 8,244 African American female samples from the Women's Health Initiative SNP Health Association Resource genome-wide association study dataset, we further examined the previous meta-analyses results by attempting to replicate 20 additional putative lipid signals with P < 10(-4). Replication confirmed rs868213, located in a splice donor region of exocyst complex component 3-like 1 (EXOC3L1) as a novel signal for HDL (additive allelic effect β = 0.02; P = 1.4 × 10(-8); meta-analyses of discovery and replication). EXOC3L1 is strongly expressed in vascular endothelium and forms part of the exocyst complex, a key facilitator of the trafficking of lipid receptors. Increasing sample sizes for genetic studies in nonEuropean populations will continue to improve our understanding of lipid metabolism. PMID:26199122

  7. Genetic meta-analysis of 15,901 African Americans identifies variation in EXOC3L1 is associated with HDL concentration.

    PubMed

    Lanktree, Matthew B; Elbers, Clara C; Li, Yun; Zhang, Guosheng; Duan, Qing; Karczewski, Konrad J; Guo, Yiran; Tragante, Vinicius; North, Kari E; Cushman, Mary; Asselbergs, Folkert W; Wilson, James G; Lange, Leslie A; Drenos, Fotios; Reiner, Alex P; Barnes, Michael R; Keating, Brendan J

    2015-09-01

    Meta-analyses of European populations has successfully identified genetic variants in over 150 loci associated with lipid levels, but results from additional ethnicities remain limited. Previously, we reported two novel lipid loci identified in a sample of 7,657 African Americans using a gene-centric array including 50,000 SNPs in 2,100 candidate genes. Initial discovery and follow-up of signals with P < 10(-5) in additional African American samples confirmed CD36 and ICAM1. Using an additional 8,244 African American female samples from the Women's Health Initiative SNP Health Association Resource genome-wide association study dataset, we further examined the previous meta-analyses results by attempting to replicate 20 additional putative lipid signals with P < 10(-4). Replication confirmed rs868213, located in a splice donor region of exocyst complex component 3-like 1 (EXOC3L1) as a novel signal for HDL (additive allelic effect β = 0.02; P = 1.4 × 10(-8); meta-analyses of discovery and replication). EXOC3L1 is strongly expressed in vascular endothelium and forms part of the exocyst complex, a key facilitator of the trafficking of lipid receptors. Increasing sample sizes for genetic studies in nonEuropean populations will continue to improve our understanding of lipid metabolism.

  8. The role of genetic and environmental factors in cardiovascular disease in African Americans.

    PubMed

    Cooper, R

    1999-03-01

    Considerable interest has been focused over the years on estimating the relative importance of genetic and environmental factors on differences in rates of cardiovascular disease in blacks and whites. However, recent advances in molecular science have helped to illuminate the underlying complexity of this problem. Attempts to impute the genetic component from "what was left over" after control for a limited set of environmental exposures is increasingly recognized as naive. The requirements for a model that could account for interactions between genetic and environmental factors far exceeds the precision of our measurements. Although it is obvious that blacks experience not only unique environmental exposures, such as white racism, but more intense exposure to common factors, such as obesity, current methods make it very difficult to summarize these effects. Simpler models, using data from large samples, could provide greater precision and might illuminate the exposure-outcome relationships common to all groups. Meanwhile, efforts to identify genetic underpinnings of complex disorders will have to reach a much higher level of development before useful conclusions can be reached about the magnitude and variation of effects between racial and ethnic groups.

  9. The management of hypertension in African Americans.

    PubMed

    Ferdinand, Keith C; Armani, Annemarie M

    2007-06-01

    The prevalence of hypertension in blacks in the United States is among the highest in the world. Compared with whites, blacks develop hypertension at an earlier age, their average blood pressures are much higher and they experience worse disease severity. Consequently, blacks have a 1.3 times greater rate of nonfatal stroke, 1.8 times greater rate of fatal stroke, 1.5 times greater rate of heart disease death, 4.2 times greater rate of end-stage kidney disease, and a 50% higher frequency of heart failure; overall, mortality due to hypertension and its consequences is 4 to 5 times more likely in African Americans than in whites. The increased prevalence of hypertension and excessive target organ damage is due to a combination of genetic and, most likely, environmental factors. There are no clinical trial data at present to suggest that lower-than-usual BP targets should be set for high-risk demographic groups such as African Americans. The primary means of prevention and early treatment of hypertension in African Americans will be the appropriate use of lifestyle modification. The International Society of Hypertension in Blacks guidelines realize that most patients will require combination therapy, many of them first-line, to reach appropriate BP goals. Although certain classes and combinations of antihypertensive agents have been well-established to be effective, the choice of drugs for combination therapy in African American patients may be different. Within the African American group, the responsiveness to monotherapy with ACE inhibitors, angiotensin receptor blockers, and beta blockers may be less than the responsiveness to diuretics and calcium channel blockers, but these differences are corrected when diuretics are added to the neurohormonal antagonists. Of note, African American patients with systolic BP >15 mm Hg or a diastolic BP >10 mm Hg above goal should be treated with first-line combination therapy.

  10. Genetic Risk Factors for Type 2 Diabetes with Pharmacologic Intervention in African-American Patients with Schizophrenia or Schizoaffective Disorder

    PubMed Central

    MR, Irvin; HW, Wiener; RP, Perry; RM, Savage; CP, Go R

    2009-01-01

    An increased prevalence of type 2 diabetes (T2D) in schizophrenia (SCZ) patients has been observed. Exposure to antipsychotics (APs) has been shown to induce metabolic dysregulation in some patients but not all treated patients. We hypothesized important candidate genes for T2D may increase risk for T2D in African-American patients with SCZ or schizoaffective disorder. The PAARTNERS study comprises African-American families with at least one proband with SCZ or schizoaffective disorder. The current study of PAARTNERS SCZ and schizoaffective disorder cases (N=820) examined single nucleotide polymorphisms (SNPs) within select T2D candidate genes including transcription factor like 7 (TCF7L2), calpain 10 (CAPN10), and ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENNP1) for association with prevalent T2D. We report association of TCF7L2 (rs7903146) with T2D under both an additive and recessive model for the risk allele T. Specifically, the odds ratio (OR) for having T2D was 1.4 (p=0.03) under an additive model and 2.4 (p=0.004) under a recessive model. We also report a marginally significant TCF7L2 by AP treatment interaction that should be investigated in future studies. CAPN10 (rs3792267) was marginally associated with T2D with OR=1.5 (p=0.08) when considering the model GG vs. AG/AA with risk allele G. ENPP1 (rs1044498) was not associated with T2D. We conclude TCF7L2, a risk factor for T2D in the general population, is also a risk factor for T2D in African-American patients with SCZ or schizoaffective disorder. Research is needed to determine if T2D associated polymorphisms are of interest in the pharmacogenetics and future treatment choices of antipsychotics in African-American patients. PMID:19643578

  11. African American Suicide

    MedlinePlus

    ... accounted for 83.8% of Caucasian elderly suicides. • Firearms were the predominant method of suicide among African ... per 100,000 annually. Source: Centers for Disease Control and Prevention. National Vital Statistics System. Mortality Data. ...

  12. Heart failure in African Americans.

    PubMed

    Yancy, Clyde W

    2005-10-10

    The demographics of the United States are changing, and in the next few decades there will no longer be a racial/ethnic majority population. Increased awareness of cardiovascular disease (CVD) in special populations is warranted as these populations increase. Heart failure carries a substantial burden on those affected, particularly African Americans, who have a disproportionate burden of heart disease. Current treatments for heart failure include angiotensin-converting enzyme inhibitors, beta-blockers, angiotensin II-receptor antagonists, and vasodilating agents. This review discusses the unique characteristics of CVD in African Americans and addresses the need for targeted treatments to reduce the excess burden found in this population.

  13. African American Males. A Critical Link in the African American Family.

    ERIC Educational Resources Information Center

    Jones, Dionne J., Ed.

    African Americans are experiencing extreme stress in the United States, and African-American males appear to suffer the most. The chapters in this volume examine some of the issues confronting African-American men today. They include: (1) "Introduction" (Dionne J. Jones); (2) "Reaffirming Young African American Males: Mentoring and Community…

  14. Genetic Determinants of Pelvic Organ Prolapse among African American and Hispanic Women in the Women's Health Initiative.

    PubMed

    Giri, Ayush; Wu, Jennifer M; Ward, Renee M; Hartmann, Katherine E; Park, Amy J; North, Kari E; Graff, Mariaelisa; Wallace, Robert B; Bareh, Gihan; Qi, Lihong; O'Sullivan, Mary J; Reiner, Alexander P; Edwards, Todd L; Velez Edwards, Digna R

    2015-01-01

    Current evidence suggests a multifactorial etiology to pelvic organ prolapse (POP), including genetic predisposition. We conducted a genome-wide association study of POP in African American (AA) and Hispanic (HP) women from the Women's Health Initiative Hormone Therapy study. Cases were defined as any POP (grades 1-3) or moderate/severe POP (grades 2-3), while controls had grade 0 POP. We performed race-specific multiple logistic regression analyses between SNPs imputed to 1000 genomes in relation to POP (grade 0 vs 1-3; grade 0 vs 2-3) adjusting for age at diagnosis, body mass index, parity, and genetic ancestry. There were 1274 controls and 1427 cases of any POP and 317 cases of moderate/severe POP. Although none of the analyses reached genome-wide significance (p<5x10-8), we noted variants in several loci that met p<10-6. In race-specific analysis of grade 0 vs 2-3, intronic SNPs in the CPE gene (rs28573326, OR:2.14; 95% CI 1.62-2.83; p = 1.0x10-7) were associated with POP in AAs, and SNPs in the gene AL132709.5 (rs1950626, OR:2.96; 95% CI 1.96-4.48, p = 2.6x10-7) were associated with POP in HPs. Inverse variance fixed-effect meta-analysis of the race-specific results showed suggestive signals for SNPs in the DPP6 gene (rs11243354, OR:1.36; p = 4.2x10-7) in the grade 0 vs 1-3 analyses and for SNPs around PGBD5 (rs740494, OR:2.17; p = 8.6x10-7) and SHC3 (rs2209875, OR:0.60; p = 9.3x10-7) in the grade 0 vs 2-3 analyses. While we did not identify genome-wide significant findings, we document several SNPs reaching suggestive statistical significance. Further interrogation of POP in larger minority samples is warranted. PMID:26545240

  15. Genetic Determinants of Pelvic Organ Prolapse among African American and Hispanic Women in the Women’s Health Initiative

    PubMed Central

    Ward, Renee M.; Hartmann, Katherine E.; Park, Amy J.; North, Kari E.; Graff, Mariaelisa; Wallace, Robert B.; Bareh, Gihan; Qi, Lihong; O'Sullivan, Mary J.; Reiner, Alexander P.; Edwards, Todd L.; Velez Edwards, Digna R.

    2015-01-01

    Current evidence suggests a multifactorial etiology to pelvic organ prolapse (POP), including genetic predisposition. We conducted a genome-wide association study of POP in African American (AA) and Hispanic (HP) women from the Women’s Health Initiative Hormone Therapy study. Cases were defined as any POP (grades 1–3) or moderate/severe POP (grades 2–3), while controls had grade 0 POP. We performed race-specific multiple logistic regression analyses between SNPs imputed to 1000 genomes in relation to POP (grade 0 vs 1–3; grade 0 vs 2–3) adjusting for age at diagnosis, body mass index, parity, and genetic ancestry. There were 1274 controls and 1427 cases of any POP and 317 cases of moderate/severe POP. Although none of the analyses reached genome-wide significance (p<5x10-8), we noted variants in several loci that met p<10−6. In race-specific analysis of grade 0 vs 2–3, intronic SNPs in the CPE gene (rs28573326, OR:2.14; 95% CI 1.62–2.83; p = 1.0x10-7) were associated with POP in AAs, and SNPs in the gene AL132709.5 (rs1950626, OR:2.96; 95% CI 1.96–4.48, p = 2.6x10-7) were associated with POP in HPs. Inverse variance fixed-effect meta-analysis of the race-specific results showed suggestive signals for SNPs in the DPP6 gene (rs11243354, OR:1.36; p = 4.2x10-7) in the grade 0 vs 1–3 analyses and for SNPs around PGBD5 (rs740494, OR:2.17; p = 8.6x10-7) and SHC3 (rs2209875, OR:0.60; p = 9.3x10-7) in the grade 0 vs 2–3 analyses. While we did not identify genome-wide significant findings, we document several SNPs reaching suggestive statistical significance. Further interrogation of POP in larger minority samples is warranted. PMID:26545240

  16. Freedom Road: Adult Education of African Americans.

    ERIC Educational Resources Information Center

    Peterson, Elizabeth A., Ed.

    This book contains six chapters by various authors about the history of African Americans' contributions and participation in adult education. The book reports on how some African American leaders saw the connection between education and the eventual freedom or uplift of the African American people. Following a foreword (Phyllis M. Cunningham) and…

  17. Engaging African Americans in Smoking Cessation Programs

    ERIC Educational Resources Information Center

    Wallen, Jacqueline; Randolph, Suzanne; Carter-Pokras, Olivia; Feldman, Robert; Kanamori-Nishimura, Mariano

    2014-01-01

    Background: African Americans are disproportionately exposed to and targeted by prosmoking advertisements, particularly menthol cigarette ads. Though African Americans begin smoking later than whites, they are less likely to quit smoking than whites. Purpose: This study was designed to explore African American smoking cessation attitudes,…

  18. African American Teaching and the Matriarchal Performance.

    ERIC Educational Resources Information Center

    Jeffries, Rhonda Baynes

    This paper discusses the role of matriarchs in African-American culture, explaining that traditionally, African-American matriarchs arise from a combination of African norms and American social positions that naturally forces them to assume leadership conditions. The roles these women assume are a response to the desire to survive in a society…

  19. Complex Syntax Production of African American Preschoolers.

    ERIC Educational Resources Information Center

    Jackson, Sandra C.; Roberts, Joanne E.

    2001-01-01

    This study examined changes in the complex syntax production of 85 African American preschoolers and the role of child (gender, age, African American English) and family (home environment) factors. Age, gender, and home environment effects were found for the amount of complex language used. African American English was not related to amount of…

  20. The Great Migration and African-American Genomic Diversity

    PubMed Central

    Barakatt, Maxime; Gignoux, Christopher R.; Errington, Jacob; Blot, William J.; Bustamante, Carlos D.; Kenny, Eimear E.; Williams, Scott M.; Aldrich, Melinda C.; Gravel, Simon

    2016-01-01

    We present a comprehensive assessment of genomic diversity in the African-American population by studying three genotyped cohorts comprising 3,726 African-Americans from across the United States that provide a representative description of the population across all US states and socioeconomic status. An estimated 82.1% of ancestors to African-Americans lived in Africa prior to the advent of transatlantic travel, 16.7% in Europe, and 1.2% in the Americas, with increased African ancestry in the southern United States compared to the North and West. Combining demographic models of ancestry and those of relatedness suggests that admixture occurred predominantly in the South prior to the Civil War and that ancestry-biased migration is responsible for regional differences in ancestry. We find that recent migrations also caused a strong increase in genetic relatedness among geographically distant African-Americans. Long-range relatedness among African-Americans and between African-Americans and European-Americans thus track north- and west-bound migration routes followed during the Great Migration of the twentieth century. By contrast, short-range relatedness patterns suggest comparable mobility of ∼15–16km per generation for African-Americans and European-Americans, as estimated using a novel analytical model of isolation-by-distance. PMID:27232753

  1. The Great Migration and African-American Genomic Diversity.

    PubMed

    Baharian, Soheil; Barakatt, Maxime; Gignoux, Christopher R; Shringarpure, Suyash; Errington, Jacob; Blot, William J; Bustamante, Carlos D; Kenny, Eimear E; Williams, Scott M; Aldrich, Melinda C; Gravel, Simon

    2016-05-01

    We present a comprehensive assessment of genomic diversity in the African-American population by studying three genotyped cohorts comprising 3,726 African-Americans from across the United States that provide a representative description of the population across all US states and socioeconomic status. An estimated 82.1% of ancestors to African-Americans lived in Africa prior to the advent of transatlantic travel, 16.7% in Europe, and 1.2% in the Americas, with increased African ancestry in the southern United States compared to the North and West. Combining demographic models of ancestry and those of relatedness suggests that admixture occurred predominantly in the South prior to the Civil War and that ancestry-biased migration is responsible for regional differences in ancestry. We find that recent migrations also caused a strong increase in genetic relatedness among geographically distant African-Americans. Long-range relatedness among African-Americans and between African-Americans and European-Americans thus track north- and west-bound migration routes followed during the Great Migration of the twentieth century. By contrast, short-range relatedness patterns suggest comparable mobility of ∼15-16km per generation for African-Americans and European-Americans, as estimated using a novel analytical model of isolation-by-distance. PMID:27232753

  2. The Great Migration and African-American Genomic Diversity.

    PubMed

    Baharian, Soheil; Barakatt, Maxime; Gignoux, Christopher R; Shringarpure, Suyash; Errington, Jacob; Blot, William J; Bustamante, Carlos D; Kenny, Eimear E; Williams, Scott M; Aldrich, Melinda C; Gravel, Simon

    2016-05-01

    We present a comprehensive assessment of genomic diversity in the African-American population by studying three genotyped cohorts comprising 3,726 African-Americans from across the United States that provide a representative description of the population across all US states and socioeconomic status. An estimated 82.1% of ancestors to African-Americans lived in Africa prior to the advent of transatlantic travel, 16.7% in Europe, and 1.2% in the Americas, with increased African ancestry in the southern United States compared to the North and West. Combining demographic models of ancestry and those of relatedness suggests that admixture occurred predominantly in the South prior to the Civil War and that ancestry-biased migration is responsible for regional differences in ancestry. We find that recent migrations also caused a strong increase in genetic relatedness among geographically distant African-Americans. Long-range relatedness among African-Americans and between African-Americans and European-Americans thus track north- and west-bound migration routes followed during the Great Migration of the twentieth century. By contrast, short-range relatedness patterns suggest comparable mobility of ∼15-16km per generation for African-Americans and European-Americans, as estimated using a novel analytical model of isolation-by-distance.

  3. Classic African American Children's Literature

    ERIC Educational Resources Information Center

    McNair, Jonda C.

    2010-01-01

    The purpose of this article is to assert that there are classic African American children's books and to identify a sampling of them. The author presents multiple definitions of the term classic based on the responses of children's literature experts and relevant scholarship. Next, the manner in which data were collected and analyzed in regard to…

  4. Wellness among African American Counselors

    ERIC Educational Resources Information Center

    Day-Vines, Norma L.; Holcomb-McCoy, Cheryl

    2007-01-01

    Although there are various definitions of wellness, few conceptual definitions have addressed the contextual dimensions of wellness relative to African American counselors. The authors present an overview of generic models of wellness, discuss factors that both inhibit and promote wellness, offer some culture-specific models of wellness, and…

  5. African American Men in College

    ERIC Educational Resources Information Center

    Cuyjet, Michael J., Ed.

    2006-01-01

    This book is a much-needed resource that includes examples of real-world programs and activities to enhance academic success in the college environment for African American men. The examples are collected from a variety of institutions across the country. With contributions from leading practitioners and scholars in the field, this book explores…

  6. Perceptions of African American and European American Teachers on the Education of African American Boys

    ERIC Educational Resources Information Center

    Bacon, Ellen; Banks, Joy; Young, Kathryn; Jackson, Francesina R.

    2007-01-01

    The authors interviewed 27 teachers (16 African American and 11 European American) on instructional factors contributing to overidentification of behavior problems in African American boys. Interviews focused on teachers' perspectives of effective teachers, teacher-student relationships, and communication styles. Analysis of the interviews showed…

  7. Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study

    PubMed Central

    Perera, Minoli A; Cavallari, Larisa H; Limdi, Nita A; Gamazon, Eric R; Konkashbaev, Anuar; Daneshjou, Roxana; Pluzhnikov, Anna; Crawford, Dana C; Wang, Jelai; Liu, Nianjun; Tatonetti, Nicholas; Bourgeois, Stephane; Takahashi, Harumi; Bradford, Yukiko; Burkley, Benjamin M; Desnick, Robert J; Halperin, Jonathan L; Khalifa, Sherief I; Langaee, Taimour Y; Lubitz, Steven A; Nutescu, Edith A; Oetjens, Matthew; Shahin, Mohamed H; Patel, Shitalben R; Sagreiya, Hersh; Tector, Matthew; Weck, Karen E; Rieder, Mark J; Scott, Stuart A; Wu, Alan HB; Burmester, James K; Wadelius, Mia; Deloukas, Panos; Wagner, Michael J; Mushiroda, Taisei; Kubo, Michiaki; Roden, Dan M; Cox, Nancy J; Altman, Russ B; Klein, Teri E; Nakamura, Yusuke; Johnson, Julie A

    2013-01-01

    Summary Background VKORC1 and CYP2C9 are important contributors to warfarin dose variability, but explain less variability for individuals of African descent than for those of European or Asian descent. We aimed to identify additional variants contributing to warfarin dose requirements in African Americans. Methods We did a genome-wide association study of discovery and replication cohorts. Samples from African-American adults (aged ≥18 years) who were taking a stable maintenance dose of warfarin were obtained at International Warfarin Pharmacogenetics Consortium (IWPC) sites and the University of Alabama at Birmingham (Birmingham, AL, USA). Patients enrolled at IWPC sites but who were not used for discovery made up the independent replication cohort. All participants were genotyped. We did a stepwise conditional analysis, conditioning first for VKORC1 −1639G→A, followed by the composite genotype of CYP2C9*2 and CYP2C9*3. We prespecified a genome-wide significance threshold of p<5×10−8 in the discovery cohort and p<0·0038 in the replication cohort. Findings The discovery cohort contained 533 participants and the replication cohort 432 participants. After the prespecified conditioning in the discovery cohort, we identified an association between a novel single nucleotide polymorphism in the CYP2C cluster on chromosome 10 (rs12777823) and warfarin dose requirement that reached genome-wide significance (p=1·51×10−8). This association was confirmed in the replication cohort (p=5·04×10−5); analysis of the two cohorts together produced a p value of 4·5×10−12. Individuals heterozygous for the rs12777823 A allele need a dose reduction of 6·92 mg/week and those homozygous 9·34 mg/week. Regression analysis showed that the inclusion of rs12777823 significantly improves warfarin dose variability explained by the IWPC dosing algorithm (21% relative improvement). Interpretation A novel CYP2C single nucleotide polymorphism exerts a clinically relevant

  8. African American Preschoolers' Language, Emergent Literacy Skills, and Use of African American English: A Complex Relation

    ERIC Educational Resources Information Center

    Connor, Carol McDonald; Craig, Holly K.

    2006-01-01

    Purpose: This study examined the relation between African American preschoolers' use of African American English (AAE) and their language and emergent literacy skills in an effort to better understand the perplexing and persistent difficulties many African American children experience learning to read proficiently. Method: African American…

  9. The landscape of recombination in African Americans.

    PubMed

    Hinch, Anjali G; Tandon, Arti; Patterson, Nick; Song, Yunli; Rohland, Nadin; Palmer, Cameron D; Chen, Gary K; Wang, Kai; Buxbaum, Sarah G; Akylbekova, Ermeg L; Aldrich, Melinda C; Ambrosone, Christine B; Amos, Christopher; Bandera, Elisa V; Berndt, Sonja I; Bernstein, Leslie; Blot, William J; Bock, Cathryn H; Boerwinkle, Eric; Cai, Qiuyin; Caporaso, Neil; Casey, Graham; Cupples, L Adrienne; Deming, Sandra L; Diver, W Ryan; Divers, Jasmin; Fornage, Myriam; Gillanders, Elizabeth M; Glessner, Joseph; Harris, Curtis C; Hu, Jennifer J; Ingles, Sue A; Isaacs, William; John, Esther M; Kao, W H Linda; Keating, Brendan; Kittles, Rick A; Kolonel, Laurence N; Larkin, Emma; Le Marchand, Loic; McNeill, Lorna H; Millikan, Robert C; Murphy, Adam; Musani, Solomon; Neslund-Dudas, Christine; Nyante, Sarah; Papanicolaou, George J; Press, Michael F; Psaty, Bruce M; Reiner, Alex P; Rich, Stephen S; Rodriguez-Gil, Jorge L; Rotter, Jerome I; Rybicki, Benjamin A; Schwartz, Ann G; Signorello, Lisa B; Spitz, Margaret; Strom, Sara S; Thun, Michael J; Tucker, Margaret A; Wang, Zhaoming; Wiencke, John K; Witte, John S; Wrensch, Margaret; Wu, Xifeng; Yamamura, Yuko; Zanetti, Krista A; Zheng, Wei; Ziegler, Regina G; Zhu, Xiaofeng; Redline, Susan; Hirschhorn, Joel N; Henderson, Brian E; Taylor, Herman A; Price, Alkes L; Hakonarson, Hakon; Chanock, Stephen J; Haiman, Christopher A; Wilson, James G; Reich, David; Myers, Simon R

    2011-07-20

    Recombination, together with mutation, gives rise to genetic variation in populations. Here we leverage the recent mixture of people of African and European ancestry in the Americas to build a genetic map measuring the probability of crossing over at each position in the genome, based on about 2.1 million crossovers in 30,000 unrelated African Americans. At intervals of more than three megabases it is nearly identical to a map built in Europeans. At finer scales it differs significantly, and we identify about 2,500 recombination hotspots that are active in people of West African ancestry but nearly inactive in Europeans. The probability of a crossover at these hotspots is almost fully controlled by the alleles an individual carries at PRDM9 (P value < 10(-245)). We identify a 17-base-pair DNA sequence motif that is enriched in these hotspots, and is an excellent match to the predicted binding target of PRDM9 alleles common in West Africans and rare in Europeans. Sites of this motif are predicted to be risk loci for disease-causing genomic rearrangements in individuals carrying these alleles. More generally, this map provides a resource for research in human genetic variation and evolution.

  10. Perceptions of family history and genetic testing and feasibility of pedigree development among African Americans with hypertension

    PubMed Central

    Pettey, Christina M; McSweeney, Jean C; Stewart, Katharine E; Price, Elvin T; Cleves, Mario A; Heo, Seongkum; Souder, Elaine

    2016-01-01

    Background Pedigree development, family history, and genetic testing are thought to be useful in improving outcomes of chronic illnesses such as hypertension (HTN). However, the clinical utility of pedigree development is still unknown. Further, little is known about African Americans’ (AAs’) perceptions of family history and genetic testing. Aims This study examined the feasibility of developing pedigrees for AAs with HTN and explored perceptions of family history and genetic research among AAs with HTN. Methods The US Surgeon General’s My Family Health Portrait was administered, and 30–60 minute in-person individual interviews were conducted. Descriptive statistics were used to analyze pedigree data. Interview transcripts were analyzed with content analysis and constant comparison. Results Twenty-nine AAs with HTN were recruited from one free clinic (15 women, 14 men; mean age 49 years, SD 9.6). Twenty-six (90%) reported their family history in sufficient detail to develop a pedigree. Perceptions of family history included knowledge of HTN in the family, culturally influenced family teaching about HTN, and response to family history of HTN. Most participants agreed to future genetic testing and DNA collection because they wanted to help others; some said they needed more information and others expressed a concern for privacy. Conclusion The majority of AAs in this sample possessed extensive knowledge of HTN within their family and were able to develop a three generation pedigree with assistance. The majority were willing to participate in future genetic research. PMID:25322748

  11. The landscape of recombination in African Americans

    PubMed Central

    Hinch, Anjali G.; Tandon, Arti; Patterson, Nick; Song, Yunli; Rohland, Nadin; Palmer, Cameron D.; Chen, Gary K.; Wang, Kai; Buxbaum, Sarah G.; Akylbekova, Meggie; Aldrich, Melinda C.; Ambrosone, Christine B.; Amos, Christopher; Bandera, Elisa V.; Berndt, Sonja I.; Bernstein, Leslie; Blot, William J.; Bock, Cathryn H.; Boerwinkle, Eric; Cai, Qiuyin; Caporaso, Neil; Casey, Graham; Cupples, L. Adrienne; Deming, Sandra L.; Diver, W. Ryan; Divers, Jasmin; Fornage, Myriam; Gillanders, Elizabeth M.; Glessner, Joseph; Harris, Curtis C.; Hu, Jennifer J.; Ingles, Sue A.; Isaacs, Williams; John, Esther M.; Kao, W. H. Linda; Keating, Brendan; Kittles, Rick A.; Kolonel, Laurence N.; Larkin, Emma; Le Marchand, Loic; McNeill, Lorna H.; Millikan, Robert C.; Murphy, Adam; Musani, Solomon; Neslund-Dudas, Christine; Nyante, Sarah; Papanicolaou, George J.; Press, Michael F.; Psaty, Bruce M.; Reiner, Alex P.; Rich, Stephen S.; Rodriguez-Gil, Jorge L.; Rotter, Jerome I.; Rybicki, Benjamin A.; Schwartz, Ann G.; Signorello, Lisa B.; Spitz, Margaret; Strom, Sara S.; Thun, Michael J.; Tucker, Margaret A.; Wang, Zhaoming; Wiencke, John K.; Witte, John S.; Wrensch, Margaret; Wu, Xifeng; Yamamura, Yuko; Zanetti, Krista A.; Zheng, Wei; Ziegler, Regina G.; Zhu, Xiaofeng; Redline, Susan; Hirschhorn, Joel N.; Henderson, Brian E.; Taylor, Herman A.; Price, Alkes L.; Hakonarson, Hakon; Chanock, Stephen J.; Haiman, Christopher A.; Wilson, James G.; Reich, David; Myers, Simon R.

    2011-01-01

    Recombination, together with mutation, is the ultimate source of genetic variation in populations. We leverage the recent mixture of people of African and European ancestry in the Americas to build a genetic map measuring the probability of crossing-over at each position in the genome, based on about 2.1 million crossovers in 30,000 unrelated African Americans. At intervals of more than three megabases it is nearly identical to a map built in Europeans. At finer scales it differs significantly, and we identify about 2,500 recombination hotspots that are active in people of West African ancestry but nearly inactive in Europeans. The probability of a crossover at these hotspots is almost fully controlled by the alleles an individual carries at PRDM9 (P<10−245). We identify a 17 base pair DNA sequence motif that is enriched in these hotspots, and is an excellent match to the predicted binding target of African-enriched alleles of PRDM9. PMID:21775986

  12. Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25.

    PubMed

    Chen, Li-Shiun; Saccone, Nancy L; Culverhouse, Robert C; Bracci, Paige M; Chen, Chien-Hsiun; Dueker, Nicole; Han, Younghun; Huang, Hongyan; Jin, Guangfu; Kohno, Takashi; Ma, Jennie Z; Przybeck, Thomas R; Sanders, Alan R; Smith, Jennifer A; Sung, Yun Ju; Wenzlaff, Angie S; Wu, Chen; Yoon, Dankyu; Chen, Ying-Ting; Cheng, Yu-Ching; Cho, Yoon Shin; David, Sean P; Duan, Jubao; Eaton, Charles B; Furberg, Helena; Goate, Alison M; Gu, Dongfeng; Hansen, Helen M; Hartz, Sarah; Hu, Zhibin; Kim, Young Jin; Kittner, Steven J; Levinson, Douglas F; Mosley, Thomas H; Payne, Thomas J; Rao, D C; Rice, John P; Rice, Treva K; Schwantes-An, Tae-Hwi; Shete, Sanjay S; Shi, Jianxin; Spitz, Margaret R; Sun, Yan V; Tsai, Fuu-Jen; Wang, Jen C; Wrensch, Margaret R; Xian, Hong; Gejman, Pablo V; He, Jiang; Hunt, Steven C; Kardia, Sharon L; Li, Ming D; Lin, Dongxin; Mitchell, Braxton D; Park, Taesung; Schwartz, Ann G; Shen, Hongbing; Wiencke, John K; Wu, Jer-Yuarn; Yokota, Jun; Amos, Christopher I; Bierut, Laura J

    2012-05-01

    Recent meta-analyses of European ancestry subjects show strong evidence for association between smoking quantity and multiple genetic variants on chromosome 15q25. This meta-analysis extends the examination of association between distinct genes in the CHRNA5-CHRNA3-CHRNB4 region and smoking quantity to Asian and African American populations to confirm and refine specific reported associations. Association results for a dichotomized cigarettes smoked per day phenotype in 27 datasets (European ancestry (N = 14,786), Asian (N = 6,889), and African American (N = 10,912) for a total of 32,587 smokers) were meta-analyzed by population and results were compared across all three populations. We demonstrate association between smoking quantity and markers in the chromosome 15q25 region across all three populations, and narrow the region of association. Of the variants tested, only rs16969968 is associated with smoking (P < 0.01) in each of these three populations (odds ratio [OR] = 1.33, 95% CI = 1.25-1.42, P = 1.1 × 10(-17) in meta-analysis across all population samples). Additional variants displayed a consistent signal in both European ancestry and Asian datasets, but not in African Americans. The observed consistent association of rs16969968 with heavy smoking across multiple populations, combined with its known biological significance, suggests rs16969968 is most likely a functional variant that alters risk for heavy smoking. We interpret additional association results that differ across populations as providing evidence for additional functional variants, but we are unable to further localize the source of this association. Using the cross-population study paradigm provides valuable insights to narrow regions of interest and inform future biological experiments.

  13. Hair care practices in African American women.

    PubMed

    Quinn, Chemene R; Quinn, Timothy M; Kelly, A Paul

    2003-10-01

    Hair care in African American women is wrought with historical and cultural issues. Dermatologists need to improve their understanding of hair and scalp disorders in their African American patient population by being informed about the styling methods commonly used by and for these patients. The styling habits described in this article are intended to encompass the hairstyles adapted by a wide range of African American women with varying hair textures.

  14. Suicidal Behaviors in the African American Community

    PubMed Central

    Crosby, Alex; Molock, Sherry Davis

    2006-01-01

    This article reviews the risk and protective factors associated with suicidal thoughts and behaviors in the African American community. The authors provide a brief review of the history of suicide research in African American communities and critique some of the paradigms and underlying assumptions that have made it difficult to address the problem of suicidal behaviors in the African American community. The article also summarizes the articles that are presented in this special edition of the Journal of Black Psychology on suicidality in the African American community. PMID:17047727

  15. Genetic variants in IGF-I, IGF-II, IGFBP-3, and adiponectin genes and colon cancer risk in African Americans and Whites

    PubMed Central

    Keku, Temitope O.; Vidal, Adriana; Oliver, Shannon; Hoyo, Catherine; Hall, Ingrid J.; Omofoye, Seun; McDoom, Maya; Worley, Kendra; Galanko, Joseph; Sandler, Robert S.; Millikan, Robert

    2014-01-01

    Purpose Evaluating genetic susceptibility may clarify effects of known environmental factors and also identify individuals at high risk. We evaluated the association of four insulin-related pathway gene polymorphisms in insulin-like growth factor-1 (IGF-I) (CA)n repeat, insulin-like growth factor-2 (IGF-II) (rs680), insulin-like growth factor binding protein-3 (IGFBP-3) (rs2854744), and adiponectin (APM1 rs1501299) with colon cancer risk, as well as relationships with circulating IGF-I, IGF-II, IGFBP-3, and C-peptide in a population-based study. Methods Participants were African Americans (231cases, 306 controls) and Whites (297 cases, 530 controls). Consenting subjects provided blood specimens, and lifestyle/diet information. Genotyping for all genes except IGF-I was performed by the 5′-exonuclease (Taqman) assay. The IGF-I (CA)n repeat was assayed by PCR, and fragment analysis. Circulating proteins were measured by enzyme immunoassays. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression. Results The IGF-I (CA)19 repeat was higher in White controls (50%) than African American controls (31%). Whites homozygous for the IGF-I (CA)19 repeat had a nearly two fold increase in risk of colon cancer (OR=1.77; 95%CI=1.15–2.73), but not African Americans (OR= 0.73, 95%CI 0.50–1.51). We observed an inverse association between the IGF-II Apa1 A-variant and colon cancer risk (OR= 0.49, 95%CI 0.28–0.88) in Whites only. Carrying the IGFBP-3 variant alleles was associated with lower IGFBP-3 protein levels, a difference most pronounced in Whites (p- trend < 0.05). Conclusions These results support an association between insulin pathway-related genes and elevated colon cancer risk in Whites but not in African Americans. PMID:22565227

  16. African American Therapists Working with African American Families: An Exploration of the Strengths Perspective in Treatment

    ERIC Educational Resources Information Center

    Bell-Tolliver, Laverne; Burgess, Ruby; Brock, Linda J.

    2009-01-01

    With the exception of Hill's (1971, 1999) work, historically much of the literature on African American families has focused more on pathology than strengths. This study used interviews with 30 African American psychotherapists, self-identified as employing a strengths perspective with African American families, to investigate which strengths they…

  17. Genetic variants in one-carbon metabolism genes and breast cancer risk in European American (EA) and African American (AA) women

    PubMed Central

    Gong, Zhihong; Yao, Song; Zirpoli, Gary; Cheng, Ting-Yuan David; Roberts, Michelle; Khoury, Thaer; Ciupak, Gregory; Davis, Warren; Pawlish, Karen; Jandorf, Lina; Bovbjerg, Dana H.; Bandera, Elisa V.; Ambrosone, Christine B.

    2015-01-01

    Folate-mediated one-carbon metabolism plays critical roles in DNA synthesis, repair, and DNA methylation. The impact of single nucleotide polymorphisms (SNPs) in folate-metabolizing enzymes has been investigated in risk of breast cancer among European or Asian populations, but not among women of African ancestry. We conducted a comprehensive analysis of SNPs in eleven genes involved in one-carbon metabolism and risk of breast cancer in 1,275 European-American (EA) and 1,299 African-American (AA) women who participated in the Women’s Circle of Health Study. Allele frequencies varied significantly between EA and AA populations. A number of these SNPs, specifically in genes including MTR, MTRR, SHMT1, TYMS, and SLC19A1, were associated with overall breast cancer risk, as well as risk by estrogen receptor (ER) status, in either EA or AA women. Associations appeared to be modified by dietary folate intake. Although single-SNP associations were not statistically significant after correcting for multiple comparisons, polygenetic score analyses revealed significant associations with breast cancer risk. Per unit increase of the risk score was associated with a modest 19% to 50% increase in risk of breast cancer overall, ER positive or ER negative cancer (all P<0.0005) in EAs or AAs. In summary, our data suggest that one-carbon metabolizing gene polymorphisms could play a role in breast cancer and that may differ between EA and AA women. PMID:25598430

  18. Coming of Age: African American Male Rites-of-Passage.

    ERIC Educational Resources Information Center

    Hill, Paul, Jr.

    An overview is provided of issues confronting the African American male, along with a strategy to nurture a new generation of African American males. Chapters 1 and 2 focus on the social status and new demographics of the African American male and the external threats that are devastating to the African American male and the African American…

  19. Improving African American Achievement in Geometry Honors

    ERIC Educational Resources Information Center

    Mims, Adrian B.

    2010-01-01

    This case study evaluated the significance of implementing an enrichment mathematics course during the summer to rising African American ninth graders entitled, "Geometry Honors Preview." In the past, 60 to 70 percent of African American students in this school district had withdrawn from Geometry Honors by the second academic quarter. This study…

  20. Cancer and the African American Experience

    Cancer.gov

    The first plenary of the EPEC-O (Education in Palliative and End-of-Life Care for Oncology) Self-Study: Cultural Considerations When Caring for African Americans explores the many factors that lead to inequalities in cancer care outcomes for African Americans.

  1. African American Undergraduates and the Academic Library

    ERIC Educational Resources Information Center

    Whitmire, Ethelene

    2006-01-01

    This study examines the academic library experiences of African American undergraduates attending a research university in the Midwest. Data collection techniques included questionnaires and ethnographic observations. The results indicated that African American undergraduates are using the academic library primarily to read and to study with their…

  2. Smoking Cessation in African-Americans.

    ERIC Educational Resources Information Center

    Ahluwalia, Jasjit S.

    1996-01-01

    Because the smoking behavior of African Americans differs considerably from that of other groups, researchers examined differences between African Americans who did and did not use the nicotine patch as an adjunct to counseling and education for smoking cessation. Results indicated the nicotine patch significantly improved six-month cessation…

  3. The African American Woman. Runta (Truth).

    ERIC Educational Resources Information Center

    Jackson, Monica L.; Watson, Betty Collier, Ed.

    1989-01-01

    The African American woman has commanded widespread public attention, but popular misconceptions of her socioeconomic role and status differ sharply from her actual situation. The following basic characteristics of the contemporary African American woman, drawn from census figures, are outlined: (1) demographically, females comprise a majority of…

  4. A Mirror Image African American Student Reflections

    ERIC Educational Resources Information Center

    Cannon Dawson, Candice

    2012-01-01

    This dissertation is a narrative inquiry research project that focuses on the collegiate experiences of African American students at both historically black colleges and universities (HBCUs) and predominantly white institutions (PWIs). I look at how African American college students who engage in race or culturally specific activities, the degree…

  5. African American Art: A Los Angeles Legacy.

    ERIC Educational Resources Information Center

    Walker, Harriet

    This curriculum unit focuses on the importance of Los Angeles (California) as a center for African American art and shows how African American artists have developed their own styles and how critics and collectors have encouraged them. The unit consists of four lessons, each of which can stand alone or be used in conjunction with the others. It…

  6. Heart Truth for African American Women

    MedlinePlus

    THE HEART TRUTH ® FOR AFRICAN AMERICAN WOMEN: AN ACTION PLAN When you hear the term “heart disease,” what’s your first reaction? Like many women, you may ... in four women dies of heart disease. For African American women, the risk of heart disease is especially ...

  7. Hidden Education among African Americans during Slavery

    ERIC Educational Resources Information Center

    Gundaker, Grey

    2007-01-01

    Background/Context: Historical studies examine aspects of African American education in and out of school in detail (Woodson 1915, 1933, Bullock 1970, Anderson 1988, Morris 1982, Rachal 1986, Rose 1964, Webber 1978, Williams 2005). Scholars of African American literacy have noted ways that education intersects other arenas such as religion and…

  8. African American Teachers and Culturally Relevant Pedagogy.

    ERIC Educational Resources Information Center

    Foster, Michele

    An overview is presented of research on African American teachers, addressing the large body of literature written by policy analysts, first-person narratives, and the sociological and anthropological literature. Policy research has identified the small number of African American teachers and has studied some reasons for this shortage and some of…

  9. Reading Comprehension among African American Graduate Students

    ERIC Educational Resources Information Center

    Onwuegbuzie, Anthony J.; Mayes, Eric; Arthur, Leslie; Johnson, Joseph; Robinson, Veronica; Ashe, Shante; Elbedour, Salman; Collins, Kathleen M. T.

    2004-01-01

    A study was conducted to examine the reading comprehension performance of African American graduate students. The result showed that though the African American sample attained statistically significantly higher levels of reading comprehension than a normative sample of undergraduate students, they achieved lower levels of reading comprehension…

  10. Microevolution of African American dental morphology.

    PubMed

    Edgar, Heather J H

    2007-04-01

    The African American (AA) gene pool is primarily the result of gene flow between two biologically disparate groups: West Africans (WA) and Americans of western European descent (EA). This research utilizes characteristics of dental morphology to trace genetic relationships among WA, western Europeans (EU), AA, and European Americans. Dental morphological traits are useful for this purpose because they are heritable, do not remodel during life (although they can be lost to wear or pathology), and can be compared equally among samples from past and present populations. The results of this research provide new information about human microevolution through time and space in a biocultural setting. The mean measure of divergence is used to analyze dental morphological data from 1,265 individuals in 25 samples grouped by ancestry and time. Three hypotheses associated with admixture in AA are tested. When compared with known history, results from dental morphological data are equivocal in documenting admixture in AA. Dental morphological traits do appear to reflect admixture in AA. However, changes in trait frequencies do not closely correspond with important cultural events and trends such as the institutionalized racism of the Civil War and Jim Crow era. Results are mixed concerning whether AA with greater admixture were more likely to take part in the Great Migration to southern urban centers and to the North.

  11. African Americans and the medical establishment.

    PubMed

    Smith, C

    1999-09-01

    The African American community's response to the AIDS epidemic has reflected the profound mistrust of the medical establishment which many African Americans feel. Among African Americans, the belief that the epidemic originated in a genocidal plot is widespread. It is thought that organized medicine has been significantly involved in this plot. If we look at African Americans' historical relationship to the medical establishment from the era of slavery to the recent past, the suspicious attitudes which make such beliefs possible can be seen as an intelligible response to a new disease which disproportionately affects African Americans. Successful medical and public health responses to the epidemic have depended and will continue to depend upon overcoming the historical legacy of suspicion and gaining the trust of the community.

  12. Misconceptions of depression in african americans.

    PubMed

    Sohail, Zohaib; Bailey, Rahn Kennedy; Richie, William D

    2014-01-01

    Major depression is a very common disabling disorder. Although the relationship between race and depression is complex, depression affects all races, all ethnic and geographic locations as well as all age groups. The prevalence of depression in African Americans is controversial, due to the paucity of research. The deficit in the knowledge and skills in treating depression in African Americans have not been adequately addressed so far. Inadequate and insufficient data on African Americans contributes to the problems of under diagnoses, misdiagnosis, and under treatment of depression. This article will highlight the existing problem of depression in Afro American with a focus on diagnostic and treatment issues.

  13. Review: Heart failure with preserved ejection fraction in African Americans.

    PubMed

    Shah, Sachil

    2012-01-01

    Heart failure (HF) affects 5,700 000 people in the United States, with heart failure with preserved ejection fraction (HFPEF) being responsible for between 30%-50% of acute admissions. Epidemiological studies and HF registries have found HFPEF patients to be older, hypertensive and to have a history of atrial fibrillation. These findings, however, may not be fully applicable to African Americans, as they have been poorly studied making up only a minority of the test subjects. This review article is intended to discuss the pathophysiology and epidemiology of HFPEF within African Americans, highlight the differences compared to Caucasian populations and review current treatment guidelines. Studies looking at African Americans in particular have shown them to be younger, female and have worse diastolic dysfunction compared to Caucasian populations. African Americans also have been shown to have a worse mortality outcome especially in patients without coronary artery disease. The treatment of HFPEF is primarily symptomatic with no survival benefit seen in randomized controlled trials. Mechanisms postulated for the worse prognosis in African Americans with HFPEF include: greater incidence of hypertension and diastolic dysfunction, undefined race-driven genetic predispositions or relative resistance to medications that treat HF in general. The biological predispositions may also be compounded by inequality of healthcare access; something still felt to exist today. Prospective studies and randomized controlled trials need to be conducted with particular emphasis on African American populations to fully elucidate this disease and to formulate race specific treatment outcomes for the future.

  14. Racism: perceptions of distress among African Americans.

    PubMed

    Thompson, Vetta L Sanders

    2002-04-01

    Some scholars have suggested that stressful living conditions are a major source of mental disorder among African Americans (Krieger, 1999; Neighbors, 1990; Kessler & Neighbors, 1986). There has, however, been debate as to whether this higher level of distress is due to racism or the fact that African Americans are more often of lower socioeconomic status. Stressors that play a significant role in mental disorder might be expected to occur more frequently among African Americans than the general population. This paper attempts to provide empirical support for the notion that racism is a separate and unique source of stress for African Americans. Specifically, it was hypothesized that African Americans would report more experiences of (1) daily stress and (2) racism than other groups and (3) the impact of racial stress would be greater among African Americans. One hundred and fifty six participants completed the Daily Stress Inventory and the Experience of Discrimination questionnaire. Multivariate analysis of variance indicated that African Americans reported higher impact of discrimination scores than European Americans. There were no gender or ethnicity differences in daily stress or the number of racial incidents reported. The implications of the data are discussed.

  15. Genome-Wide Association Meta-Analyses to Identify Common Genetic Variants Associated with Hallux Valgus in Caucasian and African Americans

    PubMed Central

    Hsu, Yi-Hsiang; Liu, Youfang; Hannan, Marian T.; Maixner, William; Smith, Shad B.; Diatchenko, Luda; Golightly, Yvonne M.; Menz, Hylton B.; Kraus, Virginia B.; Doherty, Michael; Wilson, A.G.; Jordan, Joanne M.

    2016-01-01

    Objective Hallux valgus (HV) affects ~36% of Caucasian adults. Although considered highly heritable, the underlying genetic determinants are unclear. We conducted the first genome-wide association study (GWAS) aimed to identify genetic variants associated with HV. Methods HV was assessed in 3 Caucasian cohorts (n=2,263, n=915, and n=1,231 participants, respectively). In each cohort, a GWAS was conducted using 2.5M imputed single nucleotide polymorphisms (SNPs). Mixed-effect regression with the additive genetic model adjusted for age, sex, weight and within-family correlations was used for both sex-specific and combined analyses. To combine GWAS results across cohorts, fixed-effect inverse-variance meta-analyses were used. Following meta-analyses, top-associated findings were also examined in an African American cohort (n=327). Results The proportion of HV variance explained by genome-wide genotyped SNPs was 50% in men and 48% in women. A higher proportion of genetic determinants of HV was sex-specific. The most significantly associated SNP in men was rs9675316 located on chr17q23-a24 near the AXIN2 gene (p=5.46×10−7); the most significantly associated SNP in women was rs7996797 located on chr13q14.1-q14.2 near the ESD gene (p=7.21×10−7). Genome-wide significant SNP-by-sex interaction was found for SNP rs1563374 located on chr11p15.1 near the MRGPRX3 gene (interaction p-value =4.1×10−9). The association signals diminished when combining men and women. Conclusion Findings suggest that the potential pathophysiological mechanisms of HV are complex and strongly underlined by sex-specific interactions. The identified genetic variants imply contribution of biological pathways observed in osteoarthritis as well as new pathways, influencing skeletal development and inflammation. PMID:26337638

  16. Genetic moderation of child maltreatment effects on depression and internalizing symptoms by 5-HTTLPR, BDNF, NET, and CRHR1 genes in African-American children

    PubMed Central

    Cicchetti, Dante; Rogosch, Fred A.

    2014-01-01

    Genetic moderation of the effects of child maltreatment on depression and internalizing symptoms was investigated in a sample of low-income maltreated and nonmaltreated African-American children (N = 1,096). Lifetime child maltreatment experiences were independently coded from Child Protective Services records and maternal report. Child depression and internalizing problems were assessed in the context of a summer research camp by self-report (Children’s Depression Inventory, CDI) and adult counselor-report (Teacher Report Form, TRF). DNA was obtained from buccal cell or saliva samples and genotyped for polymorphisms of the following genes: 5-HTTLPR, BDNF, NET, and CRHR1. ANCOVAs with age and gender as covariates were conducted, with maltreatment status and respective polymorphism as main effects and their GxE interactions. Maltreatment consistently was associated with higher CDI and TRF symptoms. Results for child self-report symptoms indicated a GxE interaction for BDNF and maltreatment. Additionally, BDNF and tri-allelic 5-HTTLPR interacted with child maltreatment in a GxGxE interaction. Analyses for counselor-report of child anxiety/depression symptoms on the TRF indicated moderation of child maltreatment effects by tri-allelic 5-HTTLPR. These effects were elaborated based on variation in developmental timing of maltreatment experiences. NET was found to further moderate the GxE interaction of 5-HTTLPR and maltreatment status revealing a GxGxE interaction. This GxGxE was extended by consideration of variation in maltreatment subtype experiences. Finally, GxGxE effects were observed for the co-action of BDNF and the CRHR1 haplotype. The findings illustrate the variable influence of specific genotypes in GxE interactions based on variation in maltreatment experiences and the importance of a multi-genic approach for understanding influences on depression and internalizing symptoms among African-American children. PMID:25422957

  17. The Epworth Score in African American Populations

    PubMed Central

    Hayes, Amanda L.; Spilsbury, James C.; Patel, Sanjay R.

    2009-01-01

    Introduction: African Americans have elevated scores on the Epworth Sleepiness Scale (ESS) compared to whites. The reason for this difference is not clear. Methods: Responses to the ESS were assessed in 687 patients (52.3% African American) referred to a hospital-based sleep clinic. Differences in total ESS score and the scores on individual Epworth questions were compared in African Americans and whites. Findings were validated in an independent sleep apnea research cohort of 712 subjects (57.3% African Americans). Results: African Americans in the clinic-based population had a higher mean ESS score than whites (11.4 ± 0.3 vs. 9.8 ± 0.3, p < 0.0001). This difference persisted after adjusting for sleepiness risk factors. In adjusted analyses including responses to the other ESS questions, African Americans scored significantly greater on 3 of the 8 ESS component questions: questions 2-“Watching TV,” 6-“Sitting and talking to someone,” and 7-“Sitting quietly after lunch without alcohol.” In the validation cohort, African Americans also had a higher mean ESS score (9.1 ± 0.3, vs. 8.2 ± 0.3, p = 0.04). In addition they had significantly elevated scores on questions 6 and 7 (p = 0.0002, p = 0.012 respectively) even after adjusting for responses to the other Epworth questions. Conclusions: African Americans have greater sleepiness than whites as assessed by the ESS; this is independent of sleepiness risk factors. The difference appears due primarily to differences in responses to questions 6 and 7 of the ESS questions suggesting a difference in the interpretation of these 2 questions. Citation: Hayes AL; Spilsbury JC; Patel SR. The Epworth score in African American populations. J Clin Sleep Med 2009;5(4):344-348. PMID:19968012

  18. Substance abuse in African American women.

    PubMed

    Wingo, L K

    2001-01-01

    Substance abuse is a serious problem from which, regardless of sex or race, no one is immune. Each racial and gender group has specific etiological factors relating to the use of illicit drugs. Data regarding substance abuse in African American women has only recently begun to emerge in the literature. Issues such as socio-economic, racism, and sexism, place African American women at particular risk for substance abuse. Limited availability to treatment, a lack of appropriate treatment and poor social supports impact recovery and places these women at risk for relapse. This article provides an overview of the current literature regarding substance abuse, treatment and recovery in African American women.

  19. Assessing spirituality in mentally ill African Americans.

    PubMed

    Perdue, Bobbie; Johnson, Deanna; Singley, Doretha; Jackson, Cheylon

    2006-01-01

    The case scenario illustrates the advantage of using spirituality as a tool for recovery when working with mentally ill African American clients. Often spiritual and clinical perspectives are seen as contradictory. But for African Americans, these perspectives can be mutually reinforcing. Spirituality can serve as a resource of strength. It can provide emotional consolation, inspiration, guidance, and security. It can foster personal responsibility, identity, respect for ethical codes and community building. Mental Health professionals who use spirituality as a tool for recovery can expect to have better client outcomes when working with African Americans than those who do not.

  20. Fatigue Severity among African Americans: Gender and Age Interactions.

    ERIC Educational Resources Information Center

    Song, Sharon; Jason, Leonard A.; Taylor, Renee R.; Torres-Harding, Susan R.; Helgerson, Jena; Witter, Elizabeth

    2002-01-01

    Investigated the relationship between fatigue, age, and gender among African Americans, Caucasians, and Latinos. Survey results found significant age and gender interactions among African Americans and Caucasians. African American women and older African American men had the highest fatigue rates. There was no significant difference in levels of…

  1. The African-American History of Martha's Vineyard.

    ERIC Educational Resources Information Center

    Weintraub, Elaine

    1993-01-01

    Reports on research into African American history and experiences in Martha's Vineyard (Massachusetts). Examines primary sources and oral traditions of African American cultural and social history from 1703 to the present. Discusses African American sailors, race relations, and contributions by African American individuals to the community. (CFR)

  2. The effect of neighborhood disadvantage, social ties, and genetic variation on the antisocial behavior of African American women: a multilevel analysis.

    PubMed

    Lei, Man-Kit; Simons, Ronald L; Edmond, Mary Bond; Simons, Leslie Gordon; Cutrona, Carolyn E

    2014-11-01

    Social disorganization theory posits that individuals who live in disadvantaged neighborhoods are more likely to engage in antisocial behavior than are those who live in advantaged neighborhoods and that neighborhood disadvantage asserts this effect through its disruptive impact on social ties. Past research on this framework has been limited in two respects. First, most studies have concentrated on adolescent males. In contrast, the present study focused on a sample of adult African American females. Second, past research has largely ignored individual-level factors that might explain why people who grow up in disadvantaged neighborhoods often do not engage in antisocial behavior. We investigated the extent to which genetic variation contributes to heterogeneity of response to neighborhood conditions. We found that the impact of neighborhood disadvantage on antisocial behavior was mediated by neighborhood social ties. Further, the analysis indicated that the effects of neighborhood disadvantage and social ties on antisocial behavior were moderated by genetic polymorphisms. Examination of these moderating effects provided support for the differential susceptibility model of Gene × Environment. The effect of Gene × Neighborhood Disadvantage on antisocial behavior was mediated by the effect of Gene × Neighborhood Social Ties, providing support for an expanded view of social disorganization theory.

  3. The effect of neighborhood disadvantage, social ties, and genetic variation on the antisocial behavior of African American women: A multilevel analysis

    PubMed Central

    LEI, MAN-KIT; SIMONS, RONALD L.; EDMOND, MARY BOND; SIMONS, LESLIE GORDON; CUTRONA, CAROLYN E.

    2015-01-01

    Social disorganization theory posits that individuals who live in disadvantaged neighborhoods are more likely to engage in antisocial behavior than are those who live in advantaged neighborhoods and that neighborhood disadvantage asserts this effect through its disruptive impact on social ties. Past research on this framework has been limited in two respects. First, most studies have concentrated on adolescent males. In contrast, the present study focused on a sample of adult African American females. Second, past research has largely ignored individual-level factors that might explain why people who grow up in disadvantaged neighborhoods often do not engage in antisocial behavior. We investigated the extent to which genetic variation contributes to heterogeneity of response to neighborhood conditions. We found that the impact of neighborhood disadvantage on antisocial behavior was mediated by neighborhood social ties. Further, the analysis indicated that the effects of neighborhood disadvantage and social ties on antisocial behavior were moderated by genetic polymorphisms. Examination of these moderating effects provided support for the differential susceptibility model of Gene×Environment. The effect of Gene×Neighborhood Disadvantage on antisocial behavior was mediated by the effect of Gene×Neighborhood Social Ties, providing support for an expanded view of social disorganization theory. PMID:24713449

  4. African American Women's Preparation for Childbirth From the Perspective of African American Health-Care Providers.

    PubMed

    Abbyad, Christine; Robertson, Trina Reed

    2011-01-01

    Preparation for birthing has focused primarily on Caucasian women. No studies have explored African American women's birth preparation. From the perceptions of 12 African American maternity health-care providers, this study elicited perceptions of the ways in which pregnant African American women prepare for childbirth. Focus group participants answered seven semistructured questions. Four themes emerged: connecting with nurturers, traversing an unresponsive system, the need to be strong, and childbirth classes not a priority. Recommendations for nurses and childbirth educators include: (a) self-awareness of attitudes toward African Americans, (b) empowering of clients for birthing, (c) recognition of the role that pregnant women's mothers play, (d) tailoring of childbirth classes for African American women, and (e) research on how racism influences pregnant African American women's preparation for birthing.

  5. Cognition and Health in African American Men

    PubMed Central

    Sims, Regina C.; Thorpe, Roland J.; Gamaldo, Alyssa A.; Aiken-Morgan, Adrienne T.; Hill, LaBarron K.; Allaire, Jason C.; Whitfield, Keith E.

    2015-01-01

    Objective Despite high rates of poor health outcomes, little attention has been focused on associations between prominent health factors and cognitive function in African American men, exclusively. The objective was to examine relationships between cardiovascular and pulmonary health, and cognitive function in African American men. Method Data from 257 men were pooled from two studies of African American aging. The mean age of participants was 58.15 and mean educational attainment was 11.78 years. Participants provided self-reported health and demographic information, completed cognitive measures, and had their blood pressure and peak expiratory flow assessed. Results After adjustment, significant relationships were found between average peak expiratory flow rate (APEFR) and cognitive performance measures. Discussion Results suggest that lung function is important to consider when examining cognitive function in African American men. Understanding the role of health in cognition and implications for quality of life in this population will be critical as life expectancies increase. PMID:25053802

  6. Health Conditions Common in African American Women

    MedlinePlus

    ... health. Return to top Health conditions common in African-American women Asthma Breast cancer Cancer Cervical cancer Diabetes Glaucoma and cataracts Heart disease High blood pressure High cholesterol HIV/AIDS Infant death Kidney disease Lupus Mental health ...

  7. African-Americans and Heart Disease, Stroke

    MedlinePlus

    ... more about African-Americans and stroke at our Power To End Stroke website This content was last reviewed July 2015. ... Attack • Heart Failure (HF) • Heart Valve Problems and Disease • High Blood ...

  8. Mellonee Burnim on African American Music.

    ERIC Educational Resources Information Center

    Campbell, Patricia Shehan

    1995-01-01

    Describes the role and influence of Mellonee Burnim on U.S. music education. Discusses the origins and impact of African American gospel music. Includes a list of selected resources and two lesson plans featuring gospel music. (CFR)

  9. Discussing Cancer: Communication with African Americans

    PubMed Central

    Caito, Nikki; Hood, Sula; Thompson, Vetta L. Sanders

    2015-01-01

    Regular screening for colorectal cancer (CRC) facilitates earlier detection, lowers mortality, and may reduce incidence through detection and removal of pre-cancerous polyps. Optimizing health professional delivery of CRC screening information and recommendations can assist in reducing CRC disparity in the African American community. This paper presents qualitative data on African Americans’ attitudes about health professional CRC communications based on the analysis of focus groups (N=79). Using a social-ecological framework, colorectal cancer and professional communication themes are examined to offer four general and nine cancer specific theoretically based and culturally appropriate strategies for improving health professional cancer communication with African Americans. PMID:25050658

  10. Refining the association of MHC with multiple sclerosis in African Americans.

    PubMed

    McElroy, Joseph P; Cree, Bruce A C; Caillier, Stacy J; Gregersen, Peter K; Herbert, Joseph; Khan, Omar A; Freudenberg, Jan; Lee, Annette; Bridges, S Louis; Hauser, Stephen L; Oksenberg, Jorge R; Gourraud, Pierre-Antoine

    2010-08-01

    Multiple sclerosis (MS) is a common demyelinating disease of the central nervous system mediated by autoimmune and neurodegenerative pathogenic mechanisms. Multiple genes account for its moderate heritability, but the only genetic region shown to have a large replicable effect on MS susceptibility is the major histocompatibility complex (MHC). Strong linkage disequilibrium (LD) across the MHC has made it difficult to fully characterize individual genetic contributions of this region to MS risk in previous studies. African Americans are at a lower risk for MS when compared with northern Europeans and Americans of European descent, but greater haplotypic diversity and distinct patterns of LD suggest that this population may be particularly informative for fine-mapping efforts. To examine the role of the MHC in African American MS, a case-control association study was performed with 499 African American MS patients and 750 African American controls that were genotyped for 6040 MHC region single nucleotide polymorphisms (SNPs). A replication data set consisting of 451 African American patients and 718 African American controls was genotyped for selected SNPs. Two MHC class II SNPs, rs2647040 and rs3135021, were significant in the replication cohort and partially tagged DRB1*15 alleles. Surprisingly, in comparison to similar studies of individuals of European descent, the MHC seems to play a smaller role in MS susceptibility in African Americans, consistent with pervasive genetic heterogeneity across ancestral groups, and may explain the difference in MS susceptibility between African Americans and individuals of European descent.

  11. Refining the association of MHC with multiple sclerosis in African Americans

    PubMed Central

    McElroy, Joseph P.; Cree, Bruce A. C.; Caillier, Stacy J.; Gregersen, Peter K.; Herbert, Joseph; Khan, Omar A.; Freudenberg, Jan; Lee, Annette; Bridges, S. Louis; Hauser, Stephen L.; Oksenberg, Jorge R.; Gourraud, Pierre-Antoine

    2010-01-01

    Multiple sclerosis (MS) is a common demyelinating disease of the central nervous system mediated by autoimmune and neurodegenerative pathogenic mechanisms. Multiple genes account for its moderate heritability, but the only genetic region shown to have a large replicable effect on MS susceptibility is the major histocompatibility complex (MHC). Strong linkage disequilibrium (LD) across the MHC has made it difficult to fully characterize individual genetic contributions of this region to MS risk in previous studies. African Americans are at a lower risk for MS when compared with northern Europeans and Americans of European descent, but greater haplotypic diversity and distinct patterns of LD suggest that this population may be particularly informative for fine-mapping efforts. To examine the role of the MHC in African American MS, a case–control association study was performed with 499 African American MS patients and 750 African American controls that were genotyped for 6040 MHC region single nucleotide polymorphisms (SNPs). A replication data set consisting of 451 African American patients and 718 African American controls was genotyped for selected SNPs. Two MHC class II SNPs, rs2647040 and rs3135021, were significant in the replication cohort and partially tagged DRB1*15 alleles. Surprisingly, in comparison to similar studies of individuals of European descent, the MHC seems to play a smaller role in MS susceptibility in African Americans, consistent with pervasive genetic heterogeneity across ancestral groups, and may explain the difference in MS susceptibility between African Americans and individuals of European descent. PMID:20466734

  12. The Impact of Stress on the Life History Strategies of African American Adolescents: Cognitions, Genetic Moderation, and the Role of Discrimination

    ERIC Educational Resources Information Center

    Gibbons, Frederick X.; Roberts, Megan E.; Gerrard, Meg; Li, Zhigang; Beach, Steven R. H.; Simons, Ronald L.; Weng, Chih-Yuan; Philibert, Robert A.

    2012-01-01

    The impact of 3 different sources of stress--environmental, familial (e.g., low parental investment), and interpersonal (i.e., racial discrimination)--on the life history strategies (LHS) and associated cognitions of African American adolescents were examined over an 11-year period (5 waves, from age 10.5 to 21.5). Analyses indicated that each one…

  13. Teaching African American Youth: Learning from the Lives of Three African American Social Studies Teachers

    ERIC Educational Resources Information Center

    McBride, Chantee Earl

    2010-01-01

    This study examines the life histories of three African American social studies teachers, focusing on the evolution and changes in their identities, perspectives, and attitudes related to their profession and instructional practice. In addition, the study addresses the significance of the teachers' racialized experiences as African Americans and…

  14. African American Pastors' Beliefs and Actions Regarding Childhood Incest in the African American Community

    ERIC Educational Resources Information Center

    Wells, Tesia Denis

    2012-01-01

    This quantitative study sought to explore African American pastors' beliefs and actions regarding childhood incest in the African American community and their decisions to inform the proper authorities. This exploratory study was developed in order to draw both public and academic attention to the understudied phenomenon of childhood incest…

  15. Research with African Americans: Lessons Learned about Recruiting African American Women

    ERIC Educational Resources Information Center

    Coker, Angela D.; Huang, Hsin-Hsin; Kashubeck-West, Susan

    2009-01-01

    The authors briefly explore literature related to recruiting African American research participants, reflect on their experiences conducting body image research with a sample of African American college women in an earlier study (S. Kashubeck-West et al., 2008), and discuss some methodological and cultural challenges that they encountered during…

  16. Prevalence of Stuttering in African American Preschoolers

    ERIC Educational Resources Information Center

    Proctor, Adele; Yairi, Ehud; Duff, Melissa C.; Zhang, Jie

    2008-01-01

    Purpose: In this study, the authors sought to determine the prevalence of stuttering in African American (AA) 2- to 5-year-olds as compared with same-age European Americans (EAs). Method: A total of 3,164 children participated: 2,223 AAs and 941 EAs. Data were collected using a 3-pronged approach that included investigators' individual…

  17. A comparison of type 2 diabetes risk allele load between African Americans and European Americans.

    PubMed

    Keaton, Jacob M; Cooke Bailey, Jessica N; Palmer, Nicholette D; Freedman, Barry I; Langefeld, Carl D; Ng, Maggie C Y; Bowden, Donald W

    2014-12-01

    The prevalence of type 2 diabetes (T2D) is greater in populations of African descent compared to European-descent populations. Genetic risk factors may underlie the disparity in disease prevalence. Genome-wide association studies (GWAS) have identified >60 common genetic variants that contribute to T2D risk in populations of European, Asian, African and Hispanic descent. These studies have not comprehensively examined population differences in cumulative risk allele load. To investigate the relationship between risk allele load and T2D risk, 46 T2D single nucleotide polymorphisms (SNPs) in 43 loci from GWAS in European, Asian, and African-derived populations were genotyped in 1,990 African Americans (n = 963 T2D cases, n = 1,027 controls) and 1,644 European Americans (n = 719 T2D cases, n = 925 controls) ascertained and recruited using a common protocol in the southeast United States. A genetic risk score (GRS) was constructed from the cumulative risk alleles for each individual. In African American subjects, risk allele frequencies ranged from 0.024 to 0.964. Risk alleles from 26 SNPs demonstrated directional consistency with previous studies, and 3 SNPs from ADAMTS9, TCF7L2, and ZFAND6 showed nominal evidence of association (p < 0.05). African American individuals carried 38-67 (53.7 ± 4.0, mean ± SD) risk alleles. In European American subjects, risk allele frequencies ranged from 0.084 to 0.996. Risk alleles from 36 SNPs demonstrated directional consistency, and 10 SNPs from BCL11A, PSMD6, ADAMTS9, ZFAND3, ANK1, CDKN2A/B, TCF7L2, PRC1, FTO, and BCAR1 showed evidence of association (p < 0.05). European American individuals carried 38-65 (50.9 ± 4.4) risk alleles. African Americans have a significantly greater burden of 2.8 risk alleles (p = 3.97 × 10(-89)) compared to European Americans. However, GRS modeling showed that cumulative risk allele load was associated with risk of T2D in European Americans, but only marginally in African Americans. This result

  18. A Comparison of Type 2 Diabetes Risk Allele Load between African Americans and European Americans

    PubMed Central

    Keaton, Jacob M.; Cooke Bailey, Jessica N.; Palmer, Nicholette D.; Freedman, Barry I.; Langefeld, Carl D.; Ng, Maggie C. Y.; Bowden, Donald W.

    2014-01-01

    The prevalence of type 2 diabetes (T2D) is greater in populations of African descent compared to European-descent populations. Genetic risk factors may underlie the disparity in disease prevalence. Genome-wide association studies (GWAS) have identified >60 common genetic variants that contribute to T2D risk in populations of European, Asian, African, and Hispanic descent. These studies have not comprehensively examined population differences in cumulative risk allele load. To investigate the relationship between risk allele load and T2D risk, 46 T2D single nucleotide polymorphisms (SNPs) in 43 loci from GWAS in European, Asian, and African derived populations were genotyped in 1,990 African Americans (n=963 T2D cases, n=1,027 controls) and 1,644 European Americans (n=719 T2D cases, n=925 controls) ascertained and recruited using a common protocol in the southeast United States. A genetic risk score (GRS) was constructed from the cumulative risk alleles for each individual. In African American subjects, risk allele frequencies ranged from 0.024 to 0.964. Risk alleles from 26 SNPs demonstrated directional consistency with previous studies, and 3 SNPs from ADAMTS9, TCF7L2, and ZFAND6 showed nominal evidence of association (p<0.05). African American individuals carried 38–67 (53.7 ± 4.0, mean ± SD) risk alleles. In European American subjects, risk allele frequencies ranged from 0.084 to 0.996. Risk alleles from 36 SNPs demonstrated directional consistency, and 10 SNPs from BCL11A, PSMD6, ADAMTS9, ZFAND3, ANK1, CDKN2A/B, TCF7L2, PRC1, FTO, and BCAR1 showed evidence of association (p<0.05). European American individuals carried 38–65 (50.9 ± 4.4) risk alleles. African Americans have a significantly greater burden of 2.9 risk alleles (p=3.97×10−89) compared to European Americans. However, GRS modeling showed that cumulative risk allele load was associated with risk of T2D in European Americans, but only marginally in African Americans. This result suggests that

  19. Cues used for distinguishing African American and European American voices

    NASA Astrophysics Data System (ADS)

    Thomas, Erik R.; Lass, Norman J.

    2005-04-01

    Past studies have shown that listeners can distinguish most African American and European American voices, but how they do so is poorly understood. Three experiments were designed to investigate this problem. Recordings of African American and European American college students performing various reading tasks were used as the basis for stimuli in all three. In the first experiment, stimuli were subjected to monotonization, lowpass filtering at 660 Hz, and no modification. In the second, stimuli featuring certain ethnically diagnostic vowels and control stimuli were subjected to monotonization, conversion of vowels to schwa, or no modification. In the third, stimuli featuring diagnostic vowels and control stimuli were modified so that the intonation of paired African American and European American speakers was swapped. In all three experiments, African American and European American listeners in North Carolina and European American listeners in West Virginia identified the ethnicity of the speaker of each stimulus. Vowel quality emerged as the most consistent cue for identifications. However, listeners accessed other cues differently for male and female speakers. Breathiness was correlated with identifications of male speakers but not of female speakers. F0-related factors proved more important for female speakers than for male speakers. [Work supported by NSF.

  20. Conducting Precision Medicine Research with African Americans

    PubMed Central

    Halbert, Chanita Hughes; McDonald, Jasmine; Vadaparampil, Susan; Rice, LaShanta; Jefferson, Melanie

    2016-01-01

    Importance Precision medicine is an approach to detecting, treating, and managing disease that is based on individual variation in genetic, environmental, and lifestyle factors. Precision medicine is expected to reduce health disparities, but this will be possible only if studies have adequate representation of racial minorities. Objective It is critical to anticipate the rates at which individuals from diverse populations are likely to participate in precision medicine studies as research initiatives are being developed. We evaluated the likelihood of participating in a clinical study for precision medicine. Design, Setting, Participants Observational study conducted between October 2010 and February 2011 in a national sample of African Americans. Main Outcome Measure Intentions to participate in a government sponsored study that involves providing a biospecimen and generates data that could be shared with other researchers to conduct future studies. Results One third of respondents would participate in a clinical study for precision medicine. Only gender had a significant independent association with participation intentions. Men had a 1.86 (95% CI = 1.11, 3.12, p = 0.02) increased likelihood of participating in a precision medicine study compared to women in the model that included overall barriers and facilitators. In the model with specific participation barriers, distrust was associated with a reduced likelihood of participating in the research described in the vignette (OR = 0.57, 95% CI = 0.34, 0.96, p = 0.04). Conclusion and Relevance African Americans may have low enrollment in PMI research. As PMI research is implemented, extensive efforts will be needed to ensure adequate representation. Additional research is needed to identify optimal ways of ethically describing precision medicine studies to ensure sufficient recruitment of racial minorities. PMID:27441706

  1. Cancer statistics for African Americans, 2013.

    PubMed

    DeSantis, Carol; Naishadham, Deepa; Jemal, Ahmedin

    2013-05-01

    In this article, the American Cancer Society estimates the number of new cancer cases and deaths for African Americans and compiles the most recent data on cancer incidence, mortality, survival, and screening prevalence based upon incidence data from the National Cancer Institute, the Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries and mortality data from the National Center for Health Statistics. It is estimated that 176,620 new cases of cancer and 64,880 deaths will occur among African Americans in 2013. From 2000 to 2009, the overall cancer death rate among males declined faster among African Americans than whites (2.4% vs 1.7% per year), but among females, the rate of decline was similar (1.5% vs 1.4% per year, respectively). The decrease in cancer death rates among African American males was the largest of any racial or ethnic group. The reduction in overall cancer death rates since 1990 in men and 1991 in women translates to the avoidance of nearly 200,000 deaths from cancer among African Americans. Five-year relative survival is lower for African Americans than whites for most cancers at each stage of diagnosis. The extent to which these disparities reflect unequal access to health care versus other factors remains an active area of research. Overall, progress in reducing cancer death rates has been made, although more can and should be done to accelerate this progress through ensuring equitable access to cancer prevention, early detection, and state-of-the-art treatments.

  2. African American Educational Leadership in the School Superintendency

    ERIC Educational Resources Information Center

    Smith, Eva C.

    2013-01-01

    African American educational leadership has long been part of American education and African American activism to resist oppression. However, the field of educational leadership has rarely included the contributions of African American leaders, particularly women leaders, into mainstream leadership theory and practices. This omission is difficult…

  3. Persistence among African American Males in the Honors College

    ERIC Educational Resources Information Center

    Anderson Goins, Johnell Roxann

    2014-01-01

    Retaining African American students, specifically African American males, is an issue that plagues the American higher education system. Research shows that African American male students are the lowest represented group in the gifted studies programs (Ford, 2010). Lockie and Burke (1999); Chen and DeJardins (2010) and Bell (2010a) found that…

  4. Dialect Leveling and /ai/ Monopthongization among African American Detroiters.

    ERIC Educational Resources Information Center

    Anderson, Bridget L.

    2002-01-01

    Presents evidence that Detroit African Americans are participating in a recent sound change that is typically associated with some White but not African American varieties in the American South. Reports a leveling pattern in which /ai/ monothongization has expanded to the salient pre-voiceless context in Detroit African American English (AAE).…

  5. Major depressive disorder in the African American population.

    PubMed

    Bailey, Rahn K; Patel, Milapkumar; Barker, Narviar C; Ali, Shahid; Jabeen, Shagufta

    2011-07-01

    Depression is a common mental disorder that presents with depressed mood. It can become chronic or recurrent and lead to substantial impairment in an individual's ability to function. At this level, it is identified as major depressive disorder (MDD). Depression and MDD occur across all racial and ethnic groups. Although many depressed patients are treated in primary care, depression in these settings has been underdetected and undertreated. African Americans, especially, who suffer from depression are frequently underdiagnosed and inadequately managed in primary care due to patient, physician, and treatment setting factors. Patient factors include being poor, uninsured, restrictive insurance policies, biological-genetic vulnerability, nonresponsiveness to traditional pharmacological interventions, and stigma (i.e., attitudes and perceptions of mental illness). Physician factors include diagnosis and assessment, physician characteristics, physician bias, and culture; and treatment setting factors include systemic variables such as lack of or poor access to health care, racism, environment, and patient management. African Americans are less likely to receive proper diagnosis and treatment, more likely to have depression for long periods of time, and more likely to suffer greater disability from depression. Understanding patient, physician, and treatment setting factors as contributing barriers that impede effective diagnosis and treatment of depression and MDD in African Americans is critical to effective patient management and discovery. Greater African American participation in clinical research trials also is needed to effectively improve, diagnose, and treat depression in African Americans. This article examines depression among African Americans in the context of gender, culture, and psychosocial determinants, and their engagement in clinical trials.

  6. Colorectal Cancer in African Americans: An Update

    PubMed Central

    Williams, Renee; White, Pascale; Nieto, Jose; Vieira, Dorice; Francois, Fritz; Hamilton, Frank

    2016-01-01

    This review is an update to the American College of Gastroenterology (ACG) Committee on Minority Affairs and Cultural Diversity's paper on colorectal cancer (CRC) in African Americans published in 2005. Over the past 10 years, the incidence and mortality rates of CRC in the United States has steadily declined. However, reductions have been strikingly much slower among African Americans who continue to have the highest rate of mortality and lowest survival when compared with all other racial groups. The reasons for the health disparities are multifactorial and encompass physician and patient barriers. Patient factors that contribute to disparities include poor knowledge of benefits of CRC screening, limited access to health care, insurance status along with fear and anxiety. Physician factors include lack of knowledge of screening guidelines along with disparate recommendations for screening. Earlier screening has been recommended as an effective strategy to decrease observed disparities; currently the ACG and American Society of Gastrointestinal Endoscopists recommend CRC screening in African Americans to begin at age 45. Despite the decline in CRC deaths in all racial and ethnic groups, there still exists a significant burden of CRC in African Americans, thus other strategies including educational outreach for health care providers and patients and the utilization of patient navigation systems emphasizing the importance of screening are necessary. These strategies have been piloted in both local communities and Statewide resulting in notable significant decreases in observed disparities. PMID:27467183

  7. Colorectal Cancer in African Americans: An Update.

    PubMed

    Williams, Renee; White, Pascale; Nieto, Jose; Vieira, Dorice; Francois, Fritz; Hamilton, Frank

    2016-01-01

    This review is an update to the American College of Gastroenterology (ACG) Committee on Minority Affairs and Cultural Diversity's paper on colorectal cancer (CRC) in African Americans published in 2005. Over the past 10 years, the incidence and mortality rates of CRC in the United States has steadily declined. However, reductions have been strikingly much slower among African Americans who continue to have the highest rate of mortality and lowest survival when compared with all other racial groups. The reasons for the health disparities are multifactorial and encompass physician and patient barriers. Patient factors that contribute to disparities include poor knowledge of benefits of CRC screening, limited access to health care, insurance status along with fear and anxiety. Physician factors include lack of knowledge of screening guidelines along with disparate recommendations for screening. Earlier screening has been recommended as an effective strategy to decrease observed disparities; currently the ACG and American Society of Gastrointestinal Endoscopists recommend CRC screening in African Americans to begin at age 45. Despite the decline in CRC deaths in all racial and ethnic groups, there still exists a significant burden of CRC in African Americans, thus other strategies including educational outreach for health care providers and patients and the utilization of patient navigation systems emphasizing the importance of screening are necessary. These strategies have been piloted in both local communities and Statewide resulting in notable significant decreases in observed disparities. PMID:27467183

  8. Gastrointestinal Symptoms among African Americans Undergoing Hemodialysis.

    PubMed

    Daniels, Glenda; Robinson, Janie R; Walker, Charles; Pennings, Jacquelyn S; Anderson, Staci T

    2015-01-01

    The incidence of end stage renal disease is more than three times higher in African Americans. Treatment regimens contribute to gastrointestinal (GI) complaints. This study's purpose was to examine the incidence of GI symptoms in African-American patients undergoing hemodialysis. Younger participants were more likely to report mild indigestion, while older participants reported severe indigestion or none at all. Females were more likely to report gastrointestinal symptoms. Commonly reported co-morbidities included hypertension, diabetes, and heart disease. Time on hemodialysis ranged from 1 to 279 months. Those who had been on hemodialysis the longest were more likely to report acid reflux, stomach rumbling and mild diarrhea. This study provides a foundation for early identification of GI symptoms in African-Americans patients undergoing hemodialysis.

  9. Admixture mapping of lung cancer in 1812 African-Americans.

    PubMed

    Schwartz, Ann G; Wenzlaff, Angela S; Bock, Cathryn H; Ruterbusch, Julie J; Chen, Wei; Cote, Michele L; Artis, Amanda S; Van Dyke, Alison L; Land, Susan J; Harris, Curtis C; Pine, Sharon R; Spitz, Margaret R; Amos, Christopher I; Levin, Albert M; McKeigue, Paul M

    2011-03-01

    Lung cancer continues to be the leading cause of cancer death in the USA and the best example of a cancer with undisputed evidence of environmental risk. However, a genetic contribution to lung cancer has also been demonstrated by studies of familial aggregation, family-based linkage, candidate gene studies and most recently genome-wide association studies (GWAS). The African-American population has been underrepresented in these genetic studies and has patterns of cigarette use and linkage disequilibrium that differ from patterns in other populations. Therefore, studies in African-Americans can provide complementary data to localize lung cancer susceptibility genes and explore smoking dependence-related genes. We used admixture mapping to further characterize genetic risk of lung cancer in a series of 837 African-American lung cancer cases and 975 African-American controls genotyped at 1344 ancestry informative single-nucleotide polymorphisms. Both case-only and case-control analyses were conducted using ADMIXMAP adjusted for age, sex, pack-years of smoking, family history of lung cancer, history of emphysema and study site. In case-only analyses, excess European ancestry was observed over a wide region on chromosome 1 with the largest excess seen at rs6587361 for non-small-cell lung cancer (NSCLC) (Z-score = -4.33; P = 1.5 × 10⁻⁵) and for women with NSCLC (Z-score = -4.82; P = 1.4 × 10⁻⁶). Excess African ancestry was also observed on chromosome 3q with a peak Z-score of 3.33 (P = 0.0009) at rs181696 among ever smokers with NSCLC. These results add to the findings from the GWAS in Caucasian populations and suggest novel regions of interest.

  10. What about African Americans and High Blood Pressure?

    MedlinePlus

    ANSWERS by heart Lifestyle + Risk Reduction High Blood Pressure What About African Americans and High Blood Pressure? The prevalence of high blood pressure in African Americans is among the highest in ...

  11. Genetics Home Reference: African iron overload

    MedlinePlus

    ... of a genetic condition? Genetic and Rare Diseases Information Center Frequency African iron overload is common in rural areas of central and ... more about the gene associated with African iron overload SLC40A1 Related Information What is a gene? What is a gene ...

  12. Health parties for African American study recruitment.

    PubMed

    Sadler, Georgia Robins; York, Crystal; Madlensky, Lisa; Gibson, Kathi; Wasserman, Linda; Rosenthal, Eric; Barbier, Leslie; Newman, Vicky A; Tso, Cindy

    2006-01-01

    Innovative strategies are needed to increase minorities' research participation. Using existing social networks within the African American community, "home health parties" were tested as a way to recruit African American women to a breast cancer control study. Parties included social, educational, and recruitment components. All women attending health parties consented, completed a survey, and received the study's preliminary breast cancer risk assessment. There were no differences in rates of participation for subsequent study components between women recruited via parties versus other methods. Health parties are viable recruitment strategies, reduce barriers to participation, provide a supportive environment, and are relatively inexpensive. PMID:17020516

  13. African-Americans and Hispanics remain at lower risk of ovarian cancer than non-Hispanic Whites after considering non-genetic risk factors and oophorectomy rates

    PubMed Central

    Wu, Anna H; Pearce, Celeste L; Tseng, Chiu-Chen; Pike, Malcolm C

    2015-01-01

    Background Risk factors for invasive epithelial ovarian cancer (IEOC) among Hispanics and African Americans are under-studied despite notable differences in incidence relative to non-Hispanic Whites. Methods We used multivariate logistic regression to examine parity, oral contraceptive use, tubal ligation, endometriosis, family history of ovarian cancer, and talc use and risk of IEOC among Hispanics (308 cases, 380 controls), African Americans (128 cases, 143 controls) and non-Hispanic Whites (1265 cases, 1868 controls) using four case-control studies we conducted in Los Angeles County. We expressed each of these factors in the form of increasing risk and calculated population attributable risk percentage (PAR%) estimates for the six risk factors separately and jointly in the three groups. Results The risk associations with these six well-accepted factors were comparable in the three groups. The significant racial/ethnic differences in the prevalence of these factors and differences in their oophorectomy rates explained 31% of the lower incidence in African Americans compared to non-Hispanic Whites, but only 13% of the lower incidence in Hispanics. The PAR%s ranged from 27.5% to 31.0% for no tubal ligation, 15.9% to 22.2% for not using oral contraceptives, and 12.2% to 15.1% for using talc in the three groups. Conclusions All six risk factors are comparably important in the three groups. Differences in the prevalence of these factors and their oophorectomy rates explained approximately one-third of the difference in incidence between African Americans and non-Hispanic Whites. Impact Devising strategies to lessen the burden of IEOC will be applicable to all three racial/ethnic groups. PMID:25873577

  14. Race, Culture, and the Education of African Americans

    ERIC Educational Resources Information Center

    Lynn, Marvin

    2006-01-01

    In this essay, Marvin Lynn explores a range of perspectives on African American education, with particular focus on three works: "Black American Students in an Affluent Suburb: A Study of Academic Disengagement," by social anthropologist John Ogbu; "African-Centered Pedagogy: Developing Schools of Achievement for African American Children," by…

  15. Effective Coping Strategies Employed in African-American Relationships.

    ERIC Educational Resources Information Center

    Washington, Novella Channell

    Living in a society that is quick to label and condemn, has been, and continues to be a source of pain for African-Americans. However, society's microscope has for sometime had a one dimensional lens, particularly when examining the coping styles of African-American male-female relationships within the African-American family. There exists a great…

  16. Exposure of African-American Youth to Alcohol Advertising.

    ERIC Educational Resources Information Center

    2003

    The marketing of alcohol products in African-American communities has, on occasion, stirred national controversy and met with fierce resistance from African Americans and others. Despite occasional media and community spotlights on the marketing of alcohol products in the African-American community, there has been no systematic review of the…

  17. Seeing African Americans as Competent Parents: Implications for Family Counselors

    ERIC Educational Resources Information Center

    Adkison-Bradley, Carla

    2011-01-01

    One of the primary roles of parents is to guide and socialize children to make meaningful life choices. African American parents, in particular, have the additional tasks of preparing their children to thrive in an environment that has historically been hostile toward African Americans. Yet, many African American parents are often depicted as…

  18. An Exploration of African American Students' Attitudes toward Online Learning

    ERIC Educational Resources Information Center

    Okwumabua, Theresa M.; Walker, Kristin M.; Hu, Xiangen; Watson, Andrea

    2011-01-01

    The current work presents exploratory research findings concerning African American students' attitudes toward online learning. The Online Tutoring Attitudes Scale (OTAS; Graff, 2003) was administered to 124 African American students in a positive youth development program. Findings suggest that African American students' attitudes toward…

  19. African-American Artists in Context: The Philadelphia Art Museum.

    ERIC Educational Resources Information Center

    Verdino-Sullivan, Carla Maria

    1992-01-01

    Reviews two exhibits of visual art at the Philadelphia (Pennsylvania) Art Museum, "Works by African-Americans," which showcases the contributions of nineteenth- and twentieth-century African-American artists; and "Pertaining to Philadelphia," acquisitions from the collection of Julius Bloch, an artist and mentor to many African American artists in…

  20. African American Acculturation and Black Racial Identity: A Preliminary Investigation.

    ERIC Educational Resources Information Center

    Pope-Davis, Donald B.; Liu, William M.; Ledesma-Jones, Shannon; Nevitt, Jonathan

    2000-01-01

    Examines the relationship between acculturation and racial identity among African Americans. One hundred eighty-seven African American students completed the Black Racial Identity Attitude Scale and the African American Acculturation Scale (AAAS). Acculturation was associated with three of the five AAAS subscales: Dissonance, Immersion, and…

  1. African American Males in Counseling: Who's Pulling the Trigger Now?

    ERIC Educational Resources Information Center

    Bethea-Whitfield, Patricia

    African American males face numerous challenges to their physical and psychological well-being. This project is a survey of the literature and trends relative to African American males from 1987 to the present. In reviewing the fifteen years since Parham and McDavis published their now famous article on African American men as an endangered…

  2. Registers in the Academic Writing of African American College Students

    ERIC Educational Resources Information Center

    Syrquin, Anna F.

    2006-01-01

    The study examines the development of the registers of academic writing by African American college-level students through style and grammar: indirection inherent in the oral culture of the African American community and the paratactic functions of "because." Discourse analysis of 74 samples of academic writing by 20 African American undergraduate…

  3. Representing African American Women in U.S. History Textbooks

    ERIC Educational Resources Information Center

    Schocker, Jessica B.; Woyshner, Christine

    2013-01-01

    This article addresses the dearth of African American women in high school U.S. history textbooks. The authors conducted a content analysis of the images in an African American history textbook and found that black women are underrepresented. Women are found in less than 15 percent of the images in the African American history text, while they…

  4. Perceptions of Domestic Violence: A Dialogue with African American Women

    ERIC Educational Resources Information Center

    Bent-Goodley, Tricia B.

    2004-01-01

    Although empirical research has accumulated over the past 20 years regarding African Americans and domestic violence, many questions remain about African American perceptions of domestic violence. This article explores African American women's perceptions about domestic violence through three focus groups held at a New York social services agency.…

  5. From Crisis to Empowerment: African American Women in Community Colleges

    ERIC Educational Resources Information Center

    Bates, Marcie Ann

    2012-01-01

    Social challenges tear at the fabric of the African American family, revealing complexities that identify a de facto leader, the African American woman. She exists in a chasm of overt circumstances which heavily influences her successes. The purpose of this study is to identify factors that motivated seven female African American community college…

  6. Help-Seeking Attitudes among African American College Students

    ERIC Educational Resources Information Center

    So, Dominicus W.; Gilbert, Stefanie; Romero, Sergio

    2005-01-01

    Traditionally, African American students display a low-rate of seeking mental health treatment. Issues such as mistrust of White therapists, attitudes toward mental health problems, and African American spirituality affect their help-seeking behavior. The present study examined a sample of 134 African American students at a Historically Black…

  7. Going to School: The African-American Experience.

    ERIC Educational Resources Information Center

    Lomotey, Kofi, Ed.

    This volume presents the views of a range of African-American educators on questions related to African-American academic achievement. The concern in this volume is with the persistent, pervasive, and disproportionate underachievement of African-American students. The book is divided into four parts. Part 1, "Problem Identification," comprises the…

  8. Parent Support and African American Adolescents' Career Self-Efficacy

    ERIC Educational Resources Information Center

    Alliman-Brissett, Annette E.; Turner, Sherri L.; Skovholt, Thomas M.

    2004-01-01

    Research has shown that African American adolescents are not being prepared to enter the workforce at the same rates as adolescents from other ethnic groups. While educational and career options were unavailable to African Americans in previous eras, today educational and career opportunities abound, yet many young African Americans are not in a…

  9. Oral Cancer in African Americans: Addressing Health Disparities

    ERIC Educational Resources Information Center

    Dodd, Virginia J.; Watson, Jennifer M.; Choi, Youjin; Tomar, Scott L.; Logan, Henrietta L.

    2008-01-01

    Objectives: To explore factors underlying African Americans' perceptions of oral cancer and the oral cancer exam. Study findings were used to guide development of oral cancer messages designed to increase oral cancer exams among African Americans. Methods: Focus groups were conducted to understand African Americans' attitudes and expectations…

  10. Perceptions of Discrimination and Achievement in African American Students.

    ERIC Educational Resources Information Center

    Rowley, Stephanie Johnson

    This study explored the processes that lead to relatively lower academic performance among African American students. It has been suggested that African American students perceive that, because of discrimination, education is less useful as a tool for upward mobility for African Americans than it is for members of other ethnic groups. The nature…

  11. Gender Differences in African American Attitudes toward Gay Males.

    ERIC Educational Resources Information Center

    Battle, Juan; Lemelle, Anthony J., Jr.

    2002-01-01

    Used data from the 1993 National Black Politics Study to examine the way gender worked in explaining African American attitudes toward gay men. Results indicated that African American females expressed more positive attitudes toward homosexual men than did African American males, and of the variables examined (including age, church attendance,…

  12. Effect of Genetic African Ancestry on eGFR and Kidney Disease.

    PubMed

    Udler, Miriam S; Nadkarni, Girish N; Belbin, Gillian; Lotay, Vaneet; Wyatt, Christina; Gottesman, Omri; Bottinger, Erwin P; Kenny, Eimear E; Peter, Inga

    2015-07-01

    Self-reported ancestry, genetically determined ancestry, and APOL1 polymorphisms are associated with variation in kidney function and related disease risk, but the relative importance of these factors remains unclear. We estimated the global proportion of African ancestry for 9048 individuals at Mount Sinai Medical Center in Manhattan (3189 African Americans, 1721 European Americans, and 4138 Hispanic/Latino Americans by self-report) using genome-wide genotype data. CKD-EPI eGFR and genotypes of three APOL1 coding variants were available. In admixed African Americans and Hispanic/Latino Americans, serum creatinine values increased as African ancestry increased (per 10% increase in African ancestry, creatinine values increased 1% in African Americans and 0.9% in Hispanic/Latino Americans; P≤1x10(-7)). eGFR was likewise significantly associated with African genetic ancestry in both populations. In contrast, APOL1 risk haplotypes were significantly associated with CKD, eGFR<45 ml/min per 1.73 m(2), and ESRD, with effects increasing with worsening disease states and the contribution of genetic African ancestry decreasing in parallel. Using genetic ancestry in the eGFR equation to reclassify patients as black on the basis of ≥50% African ancestry resulted in higher eGFR for 14.7% of Hispanic/Latino Americans and lower eGFR for 4.1% of African Americans, affecting CKD staging in 4.3% and 1% of participants, respectively. Reclassified individuals had electrolyte values consistent with their newly assigned CKD stage. In summary, proportion of African ancestry was significantly associated with normal-range creatinine and eGFR, whereas APOL1 risk haplotypes drove the associations with CKD. Recalculation of eGFR on the basis of genetic ancestry affected CKD staging and warrants additional investigation.

  13. Effect of Genetic African Ancestry on eGFR and Kidney Disease

    PubMed Central

    Nadkarni, Girish N.; Belbin, Gillian; Lotay, Vaneet; Wyatt, Christina; Gottesman, Omri; Bottinger, Erwin P.; Kenny, Eimear E.; Peter, Inga

    2015-01-01

    Self-reported ancestry, genetically determined ancestry, and APOL1 polymorphisms are associated with variation in kidney function and related disease risk, but the relative importance of these factors remains unclear. We estimated the global proportion of African ancestry for 9048 individuals at Mount Sinai Medical Center in Manhattan (3189 African Americans, 1721 European Americans, and 4138 Hispanic/Latino Americans by self-report) using genome-wide genotype data. CKD-EPI eGFR and genotypes of three APOL1 coding variants were available. In admixed African Americans and Hispanic/Latino Americans, serum creatinine values increased as African ancestry increased (per 10% increase in African ancestry, creatinine values increased 1% in African Americans and 0.9% in Hispanic/Latino Americans; P≤1x10−7). eGFR was likewise significantly associated with African genetic ancestry in both populations. In contrast, APOL1 risk haplotypes were significantly associated with CKD, eGFR<45 ml/min per 1.73 m2, and ESRD, with effects increasing with worsening disease states and the contribution of genetic African ancestry decreasing in parallel. Using genetic ancestry in the eGFR equation to reclassify patients as black on the basis of ≥50% African ancestry resulted in higher eGFR for 14.7% of Hispanic/Latino Americans and lower eGFR for 4.1% of African Americans, affecting CKD staging in 4.3% and 1% of participants, respectively. Reclassified individuals had electrolyte values consistent with their newly assigned CKD stage. In summary, proportion of African ancestry was significantly associated with normal-range creatinine and eGFR, whereas APOL1 risk haplotypes drove the associations with CKD. Recalculation of eGFR on the basis of genetic ancestry affected CKD staging and warrants additional investigation. PMID:25349204

  14. I too, am America: a review of research on systemic lupus erythematosus in African-Americans.

    PubMed

    Williams, Edith M; Bruner, Larisa; Adkins, Alyssa; Vrana, Caroline; Logan, Ayaba; Kamen, Diane; Oates, James C

    2016-01-01

    Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disorder that can cause significant morbidity and mortality. A large body of evidence has shown that African-Americans experience the disease more severely than other racial-ethnic groups. Relevant literature for the years 2000 to August 2015 were obtained from systematic searches of PubMed, Scopus, and the EBSCOHost platform that includes MEDLINE, CINAHL, etc. to evaluate research focused on SLE in African-Americans. Thirty-six of the 1502 articles were classified according to their level of evidence. The systematic review of the literature reported a wide range of adverse outcomes in African-American SLE patients and risk factors observed in other mono and multi-ethnic investigations. Studies limited to African-Americans with SLE identified novel methods for more precise ascertainment of risk and observed novel findings that hadn't been previously reported in African-Americans with SLE. Both environmental and genetic studies included in this review have highlighted unique African-American populations in an attempt to isolate risk attributable to African ancestry and observed increased genetic influence on overall disease in this cohort. The review also revealed emerging research in areas of quality of life, race-tailored interventions, and self-management. This review reemphasizes the importance of additional studies to better elucidate the natural history of SLE in African-Americans and optimize therapeutic strategies for those who are identified as being at high risk. PMID:27651918

  15. I too, am America: a review of research on systemic lupus erythematosus in African-Americans

    PubMed Central

    Williams, Edith M; Bruner, Larisa; Adkins, Alyssa; Vrana, Caroline; Logan, Ayaba; Kamen, Diane; Oates, James C

    2016-01-01

    Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disorder that can cause significant morbidity and mortality. A large body of evidence has shown that African-Americans experience the disease more severely than other racial-ethnic groups. Relevant literature for the years 2000 to August 2015 were obtained from systematic searches of PubMed, Scopus, and the EBSCOHost platform that includes MEDLINE, CINAHL, etc. to evaluate research focused on SLE in African-Americans. Thirty-six of the 1502 articles were classified according to their level of evidence. The systematic review of the literature reported a wide range of adverse outcomes in African-American SLE patients and risk factors observed in other mono and multi-ethnic investigations. Studies limited to African-Americans with SLE identified novel methods for more precise ascertainment of risk and observed novel findings that hadn't been previously reported in African-Americans with SLE. Both environmental and genetic studies included in this review have highlighted unique African-American populations in an attempt to isolate risk attributable to African ancestry and observed increased genetic influence on overall disease in this cohort. The review also revealed emerging research in areas of quality of life, race-tailored interventions, and self-management. This review reemphasizes the importance of additional studies to better elucidate the natural history of SLE in African-Americans and optimize therapeutic strategies for those who are identified as being at high risk.

  16. I too, am America: a review of research on systemic lupus erythematosus in African-Americans

    PubMed Central

    Williams, Edith M; Bruner, Larisa; Adkins, Alyssa; Vrana, Caroline; Logan, Ayaba; Kamen, Diane; Oates, James C

    2016-01-01

    Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disorder that can cause significant morbidity and mortality. A large body of evidence has shown that African-Americans experience the disease more severely than other racial-ethnic groups. Relevant literature for the years 2000 to August 2015 were obtained from systematic searches of PubMed, Scopus, and the EBSCOHost platform that includes MEDLINE, CINAHL, etc. to evaluate research focused on SLE in African-Americans. Thirty-six of the 1502 articles were classified according to their level of evidence. The systematic review of the literature reported a wide range of adverse outcomes in African-American SLE patients and risk factors observed in other mono and multi-ethnic investigations. Studies limited to African-Americans with SLE identified novel methods for more precise ascertainment of risk and observed novel findings that hadn't been previously reported in African-Americans with SLE. Both environmental and genetic studies included in this review have highlighted unique African-American populations in an attempt to isolate risk attributable to African ancestry and observed increased genetic influence on overall disease in this cohort. The review also revealed emerging research in areas of quality of life, race-tailored interventions, and self-management. This review reemphasizes the importance of additional studies to better elucidate the natural history of SLE in African-Americans and optimize therapeutic strategies for those who are identified as being at high risk. PMID:27651918

  17. African American Biographies: A Collection Development Challenge.

    ERIC Educational Resources Information Center

    Woody, Donna

    2000-01-01

    Discusses the lack of African American biographies for elementary school libraries and reports the results of a study that surveyed publishers from the Children's Book Council. Examines book reviews, discusses the number of sports figures included, and considers problems with a lack of appropriate materials to support the curriculum. (LRW)

  18. Paranoid Ideation among Elderly African American Persons.

    ERIC Educational Resources Information Center

    Bazargan, Mohsen; Bazargan, Shahrzad; King, Lewis

    2001-01-01

    A cross sectional study involving 998 independently living elderly African Americans used the Brief Symptom Inventory to measure paranoid ideation and 14 independent variables including demographic characteristics, cognitive deficit, and depression. Paranoid ideation was found in 10% of the sample. Regression analysis revealed 6 of 14 independent…

  19. African American English: A Linguistic Introduction.

    ERIC Educational Resources Information Center

    Green, Lisa J.

    This introduction to African American English (AAE) looks at the grammar as a whole, describing patterns in sentence structure, sound system, word formation, and word use in AAE. The book uses linguistic description and data from conversation to explain that AAE is not a compilation of random deviations from mainstream English but rather a…

  20. African American Students' Attitudes toward Entrepreneurship Education.

    ERIC Educational Resources Information Center

    Ede, Fred O.; Panigrahi, Bhagaban; Calcich, Stephen E.

    1998-01-01

    A survey of 171 African-American students found that 72% came from nonentrepreneurial family backgrounds; only 24.5% intended to start their own businesses, there were no gender differences in entrepreneurship attitudes, and seniors and those from entrepreneurial backgrounds were more favorable toward entrepreneurship. (SK)

  1. Sun protection behaviors among African Americans.

    PubMed

    Hall, H I; Rogers, J D

    1999-01-01

    The anatomic distribution of some skin cancers suggests that sun exposure may be an etiologic factor for skin cancer among African Americans. Yet little is known about sun protection behaviors among African Americans. We analyzed data from the 1992 National Health Interview Survey (N = 1,583) to determine the prevalence of sun protection behaviors and sun sensitivity. About 6% of African Americans reported being extremely sensitive to the sun and severe sunburning, and 9% reported mild burns. Overall, 53% of respondents (47% of men and 57% of women) reported that they were very likely to wear protective clothing, seek shade, or use sunscreen lotion. Women were more likely than men to report seeking shade and using sunscreen. Sun protection behaviors were more frequently reported by those who sunburn more easily and were positively associated with age. Use of sunscreen was positively associated with income and education. Education about sun protection and early detection may help reduce the morbidity and mortality of skin cancer among African Americans.

  2. African American Women Counselors, Wellness, and Spirituality

    ERIC Educational Resources Information Center

    Knowles, Debora; Bryant, Rhonda M.

    2011-01-01

    Given their tremendous professional responsibilities, professional counselors face daunting challenges to remaining healthy and avoiding role stress and overload. This article explores the intersection of race, gender, wellness, and spirituality in the self-care of African American women counselors. The authors give particular attention to…

  3. African-American Males: Education or Incarceration.

    ERIC Educational Resources Information Center

    Green, Robert L.

    This paper analyzes the relationship between levels of educational attainment and outcomes for African American males, in particular the likelihood of conflict with the criminal justice system. The analysis begins with a look at society's belief system and political and economic forces, and argues that these have combined to promote failure among…

  4. African American Female Superintendents: Resilient School Leaders

    ERIC Educational Resources Information Center

    Johnson, Bernadeia H.

    2012-01-01

    Six African American female superintendents who had served as superintendents in at least 2 school districts were interviewed to understand ways in which they responded to barriers and adversity in their roles, with a particular emphasis on issues related to sexism and racism. Study participants shared that they work to engage the community and…

  5. Educational Resilience in African American Adolescents

    ERIC Educational Resources Information Center

    Cunningham, Michael; Swanson, Dena Phillips

    2010-01-01

    The purpose of this article was to examine factors within the school context that facilitates educational resilience among African American high school students. The authors expected academic self-esteem to be positively associated with future expectations (academic and general). They expected perceptions of school-based social support to have…

  6. Legacy of a Pioneer African American Educator

    ERIC Educational Resources Information Center

    Cazers, Gunars; Curtner-Smith, Matthew

    2013-01-01

    Purpose: The purpose was to reconstruct the historical and legendary contribution of one exemplary African American physical education teacher educator who lived and worked in the Deep South prior to and immediately following the 1954 Brown v. Board of Education court case. The following questions guided data collection and analysis: To what…

  7. African American's Perceptions of Psychotherapy and Psychotherapists.

    ERIC Educational Resources Information Center

    Thompson, Vetta L. Sanders; Akbar, Maysa D.; Bazile, Anita

    The attitudes and beliefs about utilization of mental health services of 201 African Americans, 18 years and older, are explored. One hundred and thirty-four females and 66 males participated in mixed sex focus groups conducted in an urban, Midwestern city. Discussion probes addressed participant perceptions of psychotherapists and psychotherapy,…

  8. Violent Behaviors among African-American Adolescents.

    ERIC Educational Resources Information Center

    Garrett, Darhyl

    1995-01-01

    Explores the development of behaviors by using Erik Erikson's psychosocial developmental theory, with emphasis on adolescents. Examines factors, such as identity versus identity diffusion, that may be contributing to increasing acts of violence by African American adolescents. Other factors are examined that may contribute to increased violence.…

  9. 2000 African American History Month Celebration Luncheon

    NASA Technical Reports Server (NTRS)

    2000-01-01

    In the Early Space Exploration Conference Center at the KSC Visitor Complex, Dr. Julian M. Earls (left), deputy director for Operations, Glenn Research Center, receives a plaque from astronaut Joan Higginbotham (right) during the 2000 African American History Month Celebration Luncheon. Dr. Earls was guest speaker at the luncheon.

  10. African American Homeschooling Practices: Empirical Evidence

    ERIC Educational Resources Information Center

    Mazama, Ama

    2016-01-01

    Despite a significant increase in scholarly interest for homeschooling, some of its most critical aspects, such as instructional daily practices, remain grossly understudied. This essay thus seeks to fill that void by presenting empirical evidence regarding the homeschooling practices of a specific group, African Americans. Most specifically, the…

  11. 2000 African American History Month Celebration Luncheon

    NASA Technical Reports Server (NTRS)

    2000-01-01

    In the Early Space Exploration Conference Center at the KSC Visitor Complex, the planning committee for the 2000 African American History Month Celebration Luncheon gather in the lobby. At the far left is Mack McKinney, chief, Programs Resources Management, who was chairperson for the event.

  12. 2000 African American History Month Celebration Luncheon

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Mack McKinney (left), chief, Programs Resources Management, and Delores Abraham (right), with the Astronaut office, flank one of the posters decorating the Early Space Exploration Conference Center at the KSC Visitor Complex for the 2000 African American History Month Celebration Luncheon. McKinney is chairperson for the event.

  13. Marginality Theory and the African American Student.

    ERIC Educational Resources Information Center

    Grant, G. Kathleen; Breese, Jeffrey R.

    1997-01-01

    Reports on a study of African-American college students at a state university in the Midwest. The study examined the effects of marginality on their college experience and performance. Identifies six reactions to marginality and provides case study examples of each. Includes extensive references and verbatim comments from the students. (MJP)

  14. Depressive Symptoms in African-American Women.

    ERIC Educational Resources Information Center

    Reed, Michael K.; And Others

    1996-01-01

    Examined the prevalence of depressive symptoms in an African American female college student sample (n=78) using the Minnesota Multiphasic Personality Inventory (MMPI2) and the Beck Depression Inventory (BDI). MMPI-2 was a more conservative scale than BDI in identifying depressive symptom levels. Discusses stress inoculation methods to assist…

  15. Cultural Considerations When Caring for African Americans

    Cancer.gov

    The EPEC-O (Education in Palliative and End-of-Life Care for Oncology) Self-Study: Cultural Considerations When Caring for African Americans is a free comprehensive multimedia curricula for health professionals caring for persons with cancer and their families.

  16. Promotive Parenting Practices among African American Mothers

    ERIC Educational Resources Information Center

    Williams-Wheeler, Meeshay

    2011-01-01

    The purpose of this study was to examine communication/reasoning, behavioral control, and trust as predictors of resourcefulness among African American children during middle childhood (6-12 years of age). Mothers who practice promotive socialization strategies are more likely to rear children who are socially competent and well adjusted. Multiple…

  17. African American College Women's Suicide Buffers.

    ERIC Educational Resources Information Center

    Marion, Michelle S.; Range, Lillian M.

    2003-01-01

    To examine the relationships buffers may have with suicide ideation, 300 African American female college students completed measures of suicide ideation and buffers. Three variables accounted for a significant and unique portion of the variance in suicide ideation: family support, a view that suicide is unacceptable, and a collaborative religious…

  18. Gout and African Americans: Reducing disparities.

    PubMed

    Kumar, Bharat; Lenert, Petar

    2016-09-01

    African Americans are more likely to suffer from gout and are less likely to receive optimal treatment for it. Physicians should be aware of risk factors for gout and professional guidelines for treating acute attacks and high uric acid levels, and should help develop strategies to reduce disparities in healthcare delivery. PMID:27618355

  19. Careers of African Americans in Academic Astronomy.

    ERIC Educational Resources Information Center

    Fikes, Robert Jr.

    2000-01-01

    Though traditionally the field of academic astronomy has belonged almost exclusively to whites, today several black scholars are beginning to make their mark in this scientific discipline. Profiles a group of contemporary African American scholars who are astronomers and astrophysicists, noting that there are at least four black graduate students…

  20. African Americans in Television: An Afrocentric Analysis.

    ERIC Educational Resources Information Center

    Tait, Alice A.; Perry, Robert L.

    1994-01-01

    Proposes that, historically and contemporarily, African Americans were and are severely underrepresented in the Eurocentric press, portrayed stereotypically, depicted in low-status occupational roles, and denied news or public affairs programs to adequately serve their informational needs. Theories on mass media's impact on society and individuals…

  1. Language and the African American Child

    ERIC Educational Resources Information Center

    Green, Lisa J.

    2011-01-01

    How do children acquire African American English? How do they develop the specific language patterns of their communities? Drawing on spontaneous speech samples and data from structured elicitation tasks, this book explains the developmental trends in the children's language. It examines topics such as the development of tense/aspect marking,…

  2. The myth of meritocracy and African American health.

    PubMed

    Kwate, Naa Oyo A; Meyer, Ilan H

    2010-10-01

    Recent theoretical and empirical studies of the social determinants of health inequities have shown that economic deprivation, multiple levels of racism, and neighborhood context limit African American health chances and that African Americans' poor health status is predicated on unequal opportunity to achieve the American Dream. President Obama's election has been touted as a demonstration of American meritocracy-the belief that all may obtain the American Dream-and has instilled hope in African Americans. However, we argue that in the context of racism and other barriers to success, meritocratic ideology may act as a negative health determinant for African Americans.

  3. The myth of meritocracy and African American health.

    PubMed

    Kwate, Naa Oyo A; Meyer, Ilan H

    2010-10-01

    Recent theoretical and empirical studies of the social determinants of health inequities have shown that economic deprivation, multiple levels of racism, and neighborhood context limit African American health chances and that African Americans' poor health status is predicated on unequal opportunity to achieve the American Dream. President Obama's election has been touted as a demonstration of American meritocracy-the belief that all may obtain the American Dream-and has instilled hope in African Americans. However, we argue that in the context of racism and other barriers to success, meritocratic ideology may act as a negative health determinant for African Americans. PMID:20724679

  4. The Myth of Meritocracy and African American Health

    PubMed Central

    Meyer, Ilan H.

    2010-01-01

    Recent theoretical and empirical studies of the social determinants of health inequities have shown that economic deprivation, multiple levels of racism, and neighborhood context limit African American health chances and that African Americans' poor health status is predicated on unequal opportunity to achieve the American Dream. President Obama's election has been touted as a demonstration of American meritocracy—the belief that all may obtain the American Dream—and has instilled hope in African Americans. However, we argue that in the context of racism and other barriers to success, meritocratic ideology may act as a negative health determinant for African Americans. PMID:20724679

  5. "Brothers Gonna Work It Out:" Understanding the Pedagogic Performance of African American Male Teachers Working with African American Male Students

    ERIC Educational Resources Information Center

    Brown, Anthony L.

    2009-01-01

    Drawing from ethnographic data, this paper explores how African American male teachers working with African American male students performed their pedagogy. This paper highlights how teachers' understanding of African American males social and educational needs shaped their pedagogical performance. Interestingly however, teachers' performance was…

  6. Predicting Non-African American Lesbian and Heterosexual Preadoptive Couples' Openness to Adopting an African American Child

    ERIC Educational Resources Information Center

    Goldberg, Abbie E.; Smith, JuliAnna Z.

    2009-01-01

    Despite increases in transracial adoption, African American children remain the least likely to be adopted. No research has examined the factors that predict prospective adopters' willingness to adopt an African American child. This study used multilevel modeling to examine predictors of willingness to adopt an African American child in a sample…

  7. A Call to Action to Raise Achievement for African American Students. Student Achievement Policy Brief #1: African American Students

    ERIC Educational Resources Information Center

    Kober, Nancy

    2010-01-01

    One out of every six public school students in the U.S. is African American. The achievement of African American students as a group will have a significant impact on the nation's economic strength and social well-being. This brief looks at the performance of African American students on state reading and mathematics tests and considers the policy…

  8. African American Evaluations of Black English and Standard American English.

    ERIC Educational Resources Information Center

    White, Michael J.; Vandiver, Beverly J.; Becker, Maria L.; Overstreet, Belinda G.; Temple, Linda E.; Hagan, Kelly L.; Mandelbaum, Emily P.

    1998-01-01

    Studied the perceptions of 55 African American undergraduates about Black English. Students identified as not having a committed Black identity evaluated Black English as lower in status than those students with a committed Black identity. Black English was not perceived as reflecting higher social solidarity. (SLD)

  9. The African-American Legacy in American Literature.

    ERIC Educational Resources Information Center

    Abarry, Abu

    1990-01-01

    Reviews the contributions of African-American poetry to the development of English literature from the earliest Black orator through the works of Langston Hughes. Emphasizes the work of Phillis Wheatley, Paul Lawrence Dunbar,"The New Negro" writers, and Hughes. (FMW)

  10. Spirituality and Academic Performance among African American College Students.

    ERIC Educational Resources Information Center

    Walker, Katrina L.; Dixon, Vicki

    2002-01-01

    Investigated spirituality and religious participation among African American and European American college students. Student surveys indicated that African Americans had higher levels of spiritual beliefs and religious participation than did European Americans. Correlation analysis indicated that spiritual beliefs and religious participation were…

  11. Koreans in the Hood: Conflict with African Americans.

    ERIC Educational Resources Information Center

    Kim, Kwang Chung, Ed.

    The essays in this collection examine relationships between the Korean American and African American communities in Los Angeles, Chicago, and New York. The contrast between the economic power and lack of political power of Korean Americans and the political power and lack of economic power of African Americans is traced. Essays 2-5 cover Los…

  12. Lift every voice: voices of African-American lesbian elders.

    PubMed

    Woody, Imani

    2015-01-01

    Old lesbians of African descent have experienced racism, heterosexism, homophobia, and ageism. This article explores the topics of aging, ageism, heterosexism, and minority stress among older African-American lesbians. The narratives and subsequent analysis offer significant contributions to the dialogue regarding Black aging lesbians in the aging and lesbian, gay, bisexual, and transgender (LGBT) communities generally and in the African-American and African-American lesbian communities specifically.

  13. KSC kicks off African-American History Month

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Clothed in her traditional African garb, Michelle Amos, mistress of ceremonies, welcomes the audience on Feb. 3 at the kick-off of African-American History Month. The theme for this year's observation is 'Heritage and Horizons: The African-American Legacy and the Challenges of the 21st Century.' February is designated each year as a time to celebrate the achievements and contributions of African Americans to Kennedy Space Center, NASA and the nation.

  14. Assessment of the Status of African-Americans. Volume III: The Education of African-Americans.

    ERIC Educational Resources Information Center

    Willie, Charles V., Ed.; Garibaldi, Antoine M., Ed.; Reed, Wornie L., Ed.

    In 1987 a project was undertaken to assess the status of African Americans in the United States in the topical areas to be addressed by the National Research Council's Study Committee on the Status of Black Americans: education, employment, income and occupations, political participation and the administration of justice, social and cultural…

  15. Age, gender and health among African Americans.

    PubMed

    Fitzpatrick, T R; Thanh, V T

    1997-01-01

    Public policy and epidemiological studies have not adequately addressed age and gender differences on important health dimensions among African Americans. The purpose of this study was to examine gender and health among five age groups of African Americans. A sample of 1,174 respondents age 24 to 85 was selected from the 1986 Americans' Changing Lives (ACL) Study. Regression analysis was performed using a hierarchical model to examine age and gender on five dimensions of health: functional health, chronic conditions, satisfaction with health, self-ratings of health, and activities of daily living (ADL) limitations controlling for age, education, income, and marital status among five age groups of African Americans. Results revealed that in the 24-39 age group, men had fewer chronic conditions and less ADL limitations, yet rated their health poorer than their female counterparts. In the 75 and over age group men had better functional health yet were less satisfied with their health than women. Control variables were significantly related to objective and subjective dimensions of health especially among the younger age groups. Overall, gender differences persist mainly among the youngest and oldest age groups despite variations in the above demographic variables. Implications for social work practice and future research are discussed.

  16. Informing cancer prevention strategies for African Americans: the relationship of African American acculturation to fruit, vegetable, and fat intake.

    PubMed

    Ard, Jamy D; Skinner, Celette Sugg; Chen, Chuhe; Aickin, Mikel; Svetkey, Laura P

    2005-06-01

    Acculturation has been associated with health-related behaviors in African Americans. We sought to determine if there is a relationship between acculturation and dietary intake in African Americans. African Americans in the PREMIER trial completed the African American Acculturation Scale (AAAS) and 2 nonconsecutive 24-h dietary recalls (n = 238). Analysis of variance (ANOVA) and canonical correlation were used to assess relationships between acculturation and dietary intakes. Canonical correlation (p = 0.05) showed that traditional African Americans had lower intakes of fruits/vegetables and milk/dairy with higher intakes of fats, meat, and nuts. This pattern was supported by differences in the ANOVA. African American acculturation is related to dietary intake. These findings have implications for the design of cancer-related public health messages targeted to African Americans. PMID:16015458

  17. Conducting Children's Health Insurance Outreach in African American Communities.

    ERIC Educational Resources Information Center

    Patterson, Jacqueline

    In 1998, 19.7 percent of African American children were uninsured. Since a majority of African American children live in families with incomes below 200 percent of the federal poverty line, they are eligible for free or low-cost insurance coverage. This report presents strategies for facilitating the recruitment and enrollment of African American…

  18. African American Studies in the 21st Century.

    ERIC Educational Resources Information Center

    Gates, Henry Louis, Jr.

    1992-01-01

    Explores the future of African-American studies. African-American studies should be the home of free inquiry into the complexity of being of African descent in the world, rather than a closed-shop or a resurrected version of thought police. A true proliferation of ideologies and methodologies is required. (SLD)

  19. Charting the Ancestry of African Americans

    PubMed Central

    Salas, Antonio; Carracedo, Ángel; Richards, Martin; Macaulay, Vincent

    2005-01-01

    The Atlantic slave trade promoted by West European empires (15th–19th centuries) forcibly moved at least 11 million people from Africa, including about one-third from west-central Africa, to European and American destinations. The mitochondrial DNA (mtDNA) genome has retained an imprint of this process, but previous analyses lacked west-central African data. Here, we make use of an African database of 4,860 mtDNAs, which include 948 mtDNA sequences from west-central Africa and a further 154 from the southwest, and compare these for the first time with a publicly available database of 1,148 African Americans from the United States that contains 1,053 mtDNAs of sub-Saharan ancestry. We show that >55% of the U.S. lineages have a West African ancestry, with <41% coming from west-central or southwestern Africa. These results are remarkably similar to the most up-to-date analyses of the historical record. PMID:16175514

  20. African American Culture and Hypertension Prevention

    PubMed Central

    Peters, Rosalind M.; Aroian, Karen J.; Flack, John M.

    2009-01-01

    A qualitative study was done to explore attitudes and beliefs of African Americans regarding hypertension-preventive self-care behaviors. Five focus groups, with 34 participants, were held using interview questions loosely based on the Theory of Planned Behavior (TPB). Analysis revealed themes broadly consistent with the TPB, and also identified an overarching theme labeled “circle of culture.” The circle is a metaphor for ties that bind individuals within the larger African American community, and provides boundaries for culturally acceptable behaviors. Three sub-themes were identified: one describes how health behaviors are “passed from generation to generation,” another reflects a sense of being “accountable” to others within the culture; and the third reflects negative views taken toward people who are “acting different,” moving outside the circle of culture. Findings provide an expanded perspective of the TPB by demonstrating the influence of culture and collective identify on attitude formation and health-related behaviors among African Americans. PMID:17056776

  1. Neuropsychological screening tests in African Americans.

    PubMed Central

    Lampley-Dallas, V. T.

    2001-01-01

    Neuropsychological tests are instruments used to diagnose a variety of cognitive conditions. This article will review a few of the brief scales commonly used in screening for dementia. It will also discuss the properties of and problems with some of the brief scales that are commonly used to screen African Americans for dementia, highlighting the various biases. The Mini-Mental State Examination (MMSE) is the most widely known and utilized cognitive impairment instrument in the United States. Whether or not it is biased to race after adjusting the scores for educational attainment remains controversial. The Blessed Information-Memory-Concentration Test (BIMC), Blessed Orientation-Memory-Concentration Test (BOMC), Short Portable Mental Status Questionnaire (SPMSQ), and Neurobehavioral Cognitive Status Examination (NCSE) are other screening tests used to diagnose dementia. Some of these tests have been found to misclassify many more African Americans as demented compared to the proportion of whites that are misclassified. The Cambridge Cognitive Examination (CAMCOG) is the only brief neuropsychological scale designed to actually diagnose early dementia, but it is not known if it is biased for African Americans. PMID:11560287

  2. Fine-mapping IGF1 and prostate cancer risk in African Americans: the multiethnic cohort study.

    PubMed

    Giorgi, Elena E; Stram, Daniel O; Taverna, Darin; Turner, Stephen D; Schumacher, Fredrick; Haiman, Christopher A; Lum-Jones, Annette; Tirikainen, Maarit; Caberto, Christian; Duggan, David; Henderson, Brian E; Le Marchand, Loic; Cheng, Iona

    2014-09-01

    Genetic variation at insulin-like growth factor 1 (IGF1) has been linked to prostate cancer risk. However, the specific predisposing variants have not been identified. In this study, we fine-mapped the IGF1 locus for prostate cancer risk in African Americans. We conducted targeted Roche GS-Junior 454 resequencing of a 156-kb region of IGF1 in 80 African American aggressive prostate cancer cases. Three hundred and thirty-four IGF1 SNPs were examined for their association with prostate cancer risk in 1,000 African American prostate cancer cases and 991 controls. The top associated SNP in African Americans, rs148371593, was examined in an additional 3,465 prostate cancer cases and 3,425 controls of non-African American ancestry-European Americans, Japanese Americans, Latinos, and Native Hawaiians. The overall association of 334 IGF1 SNPs and prostate cancer risk was assessed using logistic kernel-machine methods. The association between each SNP and prostate cancer risk was evaluated through unconditional logistic regression. A false discovery rate threshold of q < 0.1 was used to determine statistical significance of associations. We identified 8 novel IGF1 SNPs. The cumulative effect of the 334 IGF1 SNPs was not associated with prostate cancer risk (P = 0.13) in African Americans. Twenty SNPs were nominally associated with prostate cancer at P < 0.05. The top associated SNP among African Americans, rs148371593 [minor allele frequency (MAF) = 0.03; P = 0.0014; q > 0.1], did not reach our criterion of statistical significance. This polymorphism was rare in non-African Americans (MAF < 0.003) and was not associated with prostate cancer risk (P = 0.98). Our findings do not support the role of IGF1 variants and prostate cancer risk among African Americans.

  3. American Society of Human Genetics

    MedlinePlus

    ... Researchers Say October 20, 2016 Researchers Explore How Zika Infection Causes Microcephaly October 19, 2016 The American Society of Human Genetics, Incorporated 9650 Rockville Pike • Bethesda, Maryland 20814 ...

  4. Pharmacogenetic-guided Warfarin Dosing Algorithm in African-Americans.

    PubMed

    Alzubiedi, Sameh; Saleh, Mohammad I

    2016-01-01

    We aim to develop warfarin dosing algorithm for African-Americans. We explored demographic, clinical, and genetic data from a previously collected cohort of 163 African-American patients with a stable warfarin dose. We explored 2 approaches to develop the algorithm: multiple linear regression and artificial neural network (ANN). The clinical significance of the 2 dosing algorithms was evaluated by calculating the percentage of patients whose predicted dose of warfarin was within 20% of the actual dose. Linear regression model and ANN model predicted the ideal dose in 52% and 48% of the patients, respectively. The mean absolute error using linear regression model was estimated to be 10.8 mg compared with 10.9 mg using ANN. Linear regression and ANN models identified several predictors of warfarin dose including age, weight, CYP2C9 genotype *1/*1, VKORC1 genotype, rs12777823 genotype, rs2108622 genotype, congestive heart failure, and amiodarone use. In conclusion, we developed a warfarin dosing algorithm for African-Americans. The proposed dosing algorithm has the potential to recommend warfarin doses that are close to the appropriate doses. The use of more sophisticated ANN approach did not result in improved predictive performance of the dosing algorithm except for patients of a dose of ≥49 mg/wk.

  5. Pharmacogenetic-guided Warfarin Dosing Algorithm in African-Americans.

    PubMed

    Alzubiedi, Sameh; Saleh, Mohammad I

    2016-01-01

    We aim to develop warfarin dosing algorithm for African-Americans. We explored demographic, clinical, and genetic data from a previously collected cohort of 163 African-American patients with a stable warfarin dose. We explored 2 approaches to develop the algorithm: multiple linear regression and artificial neural network (ANN). The clinical significance of the 2 dosing algorithms was evaluated by calculating the percentage of patients whose predicted dose of warfarin was within 20% of the actual dose. Linear regression model and ANN model predicted the ideal dose in 52% and 48% of the patients, respectively. The mean absolute error using linear regression model was estimated to be 10.8 mg compared with 10.9 mg using ANN. Linear regression and ANN models identified several predictors of warfarin dose including age, weight, CYP2C9 genotype *1/*1, VKORC1 genotype, rs12777823 genotype, rs2108622 genotype, congestive heart failure, and amiodarone use. In conclusion, we developed a warfarin dosing algorithm for African-Americans. The proposed dosing algorithm has the potential to recommend warfarin doses that are close to the appropriate doses. The use of more sophisticated ANN approach did not result in improved predictive performance of the dosing algorithm except for patients of a dose of ≥49 mg/wk. PMID:26355760

  6. Mayo's Older African Americans Normative Studies: WMS-R norms for African American elders.

    PubMed

    Lucas, John A; Ivnik, Robert J; Smith, Glenn E; Ferman, Tanis J; Willis, Floyd B; Petersen, Ronald C; Graff-Radford, Neill R

    2005-06-01

    Norms for African American elders on the Wechsler Memory Scale-Revised (WMS-R) were derived from a sample of 309 community-dwelling individuals participating in Mayo's Older African Americans Normative Studies (MOAANS). Normative estimates are provided for traditional WMS-R subtest scores and for supplemental procedures to evaluate forgetting rates and recognition memory. Tables are provided to convert raw WMS-R subtest and supplemental scores to age-corrected scaled scores. These may be further adjusted for years of education, if desired, by applying regression-based corrections. We anticipate that these data will enhance the diagnostic utility and clinical interpretation of WMS-R performance in older African Americans.

  7. Retention of African American Faculty in Research Universities

    ERIC Educational Resources Information Center

    Awe, Clara

    2006-01-01

    Most literature on the American professorate provides a culture of evidence that suggests that the above account represents the typical experience endured by many African American faculty members and other faculty of color. African American faculty remain under-represented in predominantly White research universities. The number of African…

  8. 75 FR 6081 - National African American History Month, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-05

    ... African American History Month, 2010 By the President of the United States of America A Proclamation In... slavery and oppression, the hope of progress, and the triumph of the American Dream. African American..., I, BARACK OBAMA, President of the United States of America, by virtue of the authority vested in...

  9. Discrimination, Mastery, and Depressive Symptoms among African American Men

    ERIC Educational Resources Information Center

    Watkins, Daphne C.; Hudson, Darrell L.; Caldwell, Cleopatra Howard; Siefert, Kristine; Jackson, James S.

    2011-01-01

    Purpose: This study examines the influence of discrimination and mastery on depressive symptoms for African American men at young (18-34), middle (35-54), and late (55+) adulthood. Method: Analyses are based on responses from 1,271 African American men from the National Survey of American Life (NSAL). Results: Discrimination was significantly…

  10. The Future of African-Americans to the Year 2000.

    ERIC Educational Resources Information Center

    Congressional Task Force on the Future of African-Americans, Washington, DC.

    This study considers the present condition of African-Americans and makes projections for the year 2000, emphasizing the relative conditions of European-Americans and African-Americans, and considering the public and private policy implications of these projections. Section 1, an overview of the subject, covers the following topics: (1) "The…

  11. Phonological Awareness Skills in Young African American English Speakers

    ERIC Educational Resources Information Center

    Mitri, Souraya Mansour; Terry, Nicole Patton

    2014-01-01

    The purpose of this study was to examine African American children's performance on a phonological awareness task that included items reflecting differences between African American English (AAE) and mainstream American English. The relationship between spoken production of AAE forms and performance on phonological awareness, vocabulary, and…

  12. Defining and overcoming barriers between Euro-American chaplains and African American families.

    PubMed

    Bradley, Joe

    2009-01-01

    This article describes various communication barriers between Euro-American chaplains and African American families which prevent effective spiritual care. These barriers include covert and deeply internalized racism, belief in false ideologies, persistent stereotyping, and being unaware of white privilege. Proposes potential solutions of acknowledging ones own race; becoming sensitive to the history and continuing oppression of Euro-Americans toward African Americans; building multicultural competence through education; and building equal-status relationships with African American individuals.

  13. Perspectives from the historic African American medical institutions.

    PubMed

    Epps, C H

    1999-05-01

    The historically African American medical schools have been at the center of medical education for African American physicians in the United States since the Howard University College of Medicine opened in 1868. Although there were more than a dozen African American medical schools established during the next few decades, as propriety or church affiliated schools, only two survived the Flexner Report in 1910. Howard University (1868) and Meharry (1876) survived and trained generations of African Americans. These two schools educated approximately 85% of all African American physicians whereas the majority medical schools educated 15% for more than half of the twentieth century. As the result of a series of lawsuits filed by the National Association for the Advancement of Colored People, civil rights legislation and affirmative action programs, the numbers of the schools that now admitted African Americans increased and the total numbers of African American medical students increased when discrimination was prohibited in 1966. The percentage of African American medical students attending predominantly white institutions increased by 25% in 1948, by 47% in 1968, by 61% in 1983 and to 84% in 1990. Two additional predominantly African American medical schools were established: the Charles R. Drew Medical School, Los Angeles (affiliated with the University of California, Los Angeles) in 1966, and Morehouse Medical School, Atlanta, which admitted its first class in 1978. Recent court decisions prohibiting schools from considering race as factor in admission and the end of affirmative action programs have resulted in a drop in total minority enrollment. The historically African American medical schools, that admitted approximately 15% of the African American medical students during the era of affirmative action programs, will see this percentage decrease as the majority institutions admit fewer African American medical students and minority students. In the United States

  14. KSC kicks off African-American History Month

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Michelle Amos, mistress of ceremonies for the kick-off of African-American History Month, works with the audience to assist them in the pronunciation of a few token words in native Swahili. The theme for this year's observation is 'Heritage and Horizons: The African-American Legacy and the Challenges of the 21st Century.' February is designated each year as a time to celebrate the achievements and contributions of African Americans to Kennedy Space Center, NASA and the nation.

  15. African American women and breastfeeding: an integrative literature review.

    PubMed

    Spencer, Becky S; Grassley, Jane S

    2013-07-01

    The purpose of this article is to present a review of literature regarding factors that influence breastfeeding intentions, initiation, and duration in the African American population. Research related to health disparities experienced by African Americans in the United States, as well as research regarding the protective benefits of breastfeeding for those specific health disparities, are also presented. Community and institutional interventions and promotional campaigns aimed at increasing initiation and duration of breastfeeding in the African American population are discussed. Future research regarding African American women's breastfeeding experiences using Black feminist thought as a theoretical foundation is recommended.

  16. Critical social theory and the domination of African American Women.

    PubMed

    Davis, S P

    1995-01-01

    This historical reconstruction of the experiences of African American women in America from slavery to the present exposes the prevailing and enduring system of White male domination. From White men having control of their reproductive choices, to conspiracy to withhold the right to vote, African American women were victims of both sexism and racism. Later, as a result of the myth conceived by White sociologists of the super African American woman, further divisiveness became apparent in the African American home. As African American women took advantage of educational opportunities only to find that there was a dearth of similarly educated African American males to marry, increasing numbers of African American men were reported as parties to violent acts, drugs or illness. All of these variables are conjectured as impacting on the African American woman's experience. Lastly, data were presented depicting the increasing trend of African American women marrying White men, and the emergence of a more diverse workforce. It was concluded that economics serve as a catalyst for this change in human relations.

  17. Perspectives of African-American women on infant mortality.

    PubMed

    Barnes, Glenna L

    2008-01-01

    Twice as many African-American infants die each year when compared to White infants. This study explores the lived experiences of African-American women to identify factors related to this racial gap in infant mortality. Thirteen African-American women from two Virginia towns participated in either a focus group or in-depth interviews. Content and interpretive analysis revealed several themes. Participants indicated that the experiences of stress and racism are constant factors in African-American women's lives and are inseparable from their pregnancy experiences. Participants noted the importance of social support and the health care provider-client relationship for positive pregnancy outcomes.

  18. African American legislators' perceptions of firearm violence prevention legislation.

    PubMed

    Payton, Erica; Thompson, Amy; Price, James H; Sheu, Jiunn-Jye; Dake, Joseph A

    2015-06-01

    Firearm mortality is the leading cause of death for young African American males, however, few studies have focused on racial/ethnic minority populations and firearm violence. The National Black Caucus of State Legislators advocates for legislation that promotes the health of African Americans. Thus, the purpose of this study was to collect baseline data on African American legislators' perceptions regarding firearm violence in the African American community. A cross-sectional study of African American legislators (n = 612) was conducted to investigate the research questions. Of the 612 questionnaires mailed, 12 were not deliverable, and 170 were returned (28%). Utilizing a three wave mailing process, African American legislators were invited to participate in the study. The majority (88%) of respondents perceived firearm violence to be very serious among African Americans. Few (10%) legislators perceived that addressing legislative issues would be an effective strategy in reducing firearm violence among African Americans. The majority (72%) of legislators perceived the most effective strategy to reducing firearm violence in the African American community should focus on addressing societal issues (e.g. crime and poverty). After adjusting for the number of perceived barriers, the number of perceived benefits was a significant predictor of legislators' perceived effectiveness of firearm violence prevention legislation for 8 of the 24 potential firearm violence prevention legislative bills.

  19. Black and Blue: Depression and African American Men.

    PubMed

    Plowden, Keith O; Thompson Adams, Linda; Wiley, Dana

    2016-10-01

    Depression is a common mental disorder affecting individuals. Although many strides have been made in the area of depression, little is known about depression in special populations, especially African American men. African American men often differ in their presentation of depression and are often misdiagnosed. African American men are at greater risk for depression, but they are less likely to participate in mental health care. This article explores depression in African American by looking at environmental factors, sigma, role, and other unique to this populations, such as John Henryism. Interventions to encourage early screening and participation in care are also discussed.

  20. Ending the epidemic of heterosexual HIV transmission among African Americans.

    PubMed

    Adimora, Adaora A; Schoenbach, Victor J; Floris-Moore, Michelle A

    2009-11-01

    This article examines factors responsible for the stark racial disparities in HIV infection in the U.S. and the now concentrated epidemic among African Americans. Sexual network patterns characterized by concurrency and mixing among different subpopulations, together with high rates of other sexually transmitted infections, facilitate dissemination of HIV among African Americans. The social and economic environment in which many African Americans live shapes sexual network patterns and increases personal infection risk almost independently of personal behavior. The African-American HIV epidemic constitutes a national crisis whose successful resolution will require modifying the social and economic systems, structures, and processes that facilitate HIV transmission in this population.

  1. Ending the Epidemic of Heterosexual HIV Transmission Among African Americans

    PubMed Central

    Adimora, Adaora A.; Schoenbach, Victor J.; Floris-Moore, Michelle A.

    2014-01-01

    This article examines factors responsible for the stark racial disparities in HIV infection in the U.S. and the now concentrated epidemic among African Americans. Sexual network patterns characterized by concurrency and mixing among different subpopulations, together with high rates of other sexually transmitted infections, facilitate dissemination of HIV among African Americans. The social and economic environment in which many African Americans live shapes sexual network patterns and increases personal infection risk almost independently of personal behavior. The African American HIV epidemic constitutes a national crisis whose successful resolution will require modifying the social and economic systems, structures, and processes that facilitate HIV transmission in this population. PMID:19840704

  2. HIV health crisis and African Americans: a cultural perspective.

    PubMed

    Plowden, K; Miller, J L; James, T

    2000-01-01

    While incidence of new HIV infections have decreased in the overall population, the numbers continue to rise in African-Americans creating a serious health emergency. Studies seem to imply that part of the rise is due to HIV beliefs and high risk behaviors among African Americans. Due to certain societal factors, African Americans appear to be at greater risk for contracting the virus. This article will examine these critical social factors and their impact on this current state of emergency in the African American community using Leininger's theory of Culture Care and Universality. Implications for health providers are also addressed. PMID:11760310

  3. African American Literature, 1989-94: An Annotated Bibliography.

    ERIC Educational Resources Information Center

    Miller, R. Baxter; Butts, Tracy; Jones, Sharon

    1997-01-01

    Contains an annotated bibliography of African American literature (published between 1989 and 1994), including anthologies, fiction, poetry, drama, criticism, cultural studies, biography, interviews, and letters. (TB)

  4. Novel Risk Factors for Type 2 Diabetes in African-Americans.

    PubMed

    Chatterjee, Ranee; Maruthur, Nisa M; Edelman, David

    2015-12-01

    In the USA, compared to whites, African-Americans are disproportionately impacted by the diabetes epidemic. Traditional diabetes risk factors, such as obesity, are more common among African-Americans, but these traditional risk factors do not explain all of the disparity in diabetes risk. Recent research has identified novel environmental, lifestyle, physiologic, and genetic risk factors for diabetes, some of which appear to impact African-Americans more than whites. This manuscript reviews the recent literature to highlight some of these novel risk factors that may be contributing to the racial disparity in diabetes risk. Further study is needed of the modifiable risk factors for development of interventions to reduce the risk of diabetes in African-Americans, as well as other high-risk populations.

  5. Raising Cultural Awareness of Second Grade African American Students Using Mexican American Children's Literature

    ERIC Educational Resources Information Center

    Pugh, Sandra Lyniece

    2009-01-01

    An increase in the Mexican American population within the predominantly African American community and school was the basis of this qualitative study. The purpose of the study was to introduce African American second grade students to authentic Mexican and Mexican American children's literature. Interactive read-alouds of nonfiction and realistic…

  6. Screening for Depression in African American Churches

    PubMed Central

    Hankerson, Sidney H.; Lee, Young A; Brawley, David K.; Braswell, Kenneth; Wickramaratne, Priya J.; Weissman, Myrna M.

    2015-01-01

    Introduction Substantial racial/ethnic disparities exist in the identification and management of major depression.1 Faith-Based Health Promotion interventions reduce disparities in health screenings for numerous medical conditions.2 However, the feasibility of systematically screening for depression in faith-based settings has not been investigated. The purpose of this study was to assess the feasibility of using a validated instrument to screen for depression in African American churches. Methods Participants were recruited between October and November 2012 at three predominantly African American churches in New York City. A participatory research approach was used to determine screening days. The Patient Health Questionnaire-9 (PHQ-9) was administered to 122 participants. Positive depression screen was defined as a PHQ-9 score ≥10. Descriptive statistics were used to report sample characteristics, prevalence of participants who screened positive, and history of help seeking. Logistic regression analyses were conducted to determine the association of positive depression screen and sociodemographic characteristics. Initial analyses were conducted in 2013, with additional analyses in 2014. Results The prevalence estimate for positive depression screen was 19.7%. More men (22.5%) screened positive than women (17.7%). Total household income was inversely related to positive depression screen. A similar percentage of respondents had previously sought help from primary care providers as from clergy. Conclusions It was feasible to screen for depression with the PHQ-9 in African American churches. The prevalence of positive depression screen was high, especially among black men. Churches may be an important setting in which to identify depressive symptoms in this underserved population. PMID:26232907

  7. Equipping African American Clergy to Recognize Depression.

    PubMed

    Anthony, Jean Spann; Morris, Edith; Collins, Charles W; Watson, Albert; Williams, Jennifer E; Ferguson, Bʼnai; Ruhlman, Deborah L

    2016-01-01

    Many African Americans (AAs) use clergy as their primary source of help for depression, with few being referred to mental health providers. This study used face-to-face workshops to train AA clergy to recognize the symptoms and levels of severity of depression. A pretest/posttest format was used to test knowledge (N = 42) about depression symptoms. Results showed that the participation improved the clergy's ability to recognize depression symptoms. Faith community nurses can develop workshops for clergy to improve recognition and treatment of depression.

  8. Equipping African American Clergy to Recognize Depression.

    PubMed

    Anthony, Jean Spann; Morris, Edith; Collins, Charles W; Watson, Albert; Williams, Jennifer E; Ferguson, Bʼnai; Ruhlman, Deborah L

    2016-01-01

    Many African Americans (AAs) use clergy as their primary source of help for depression, with few being referred to mental health providers. This study used face-to-face workshops to train AA clergy to recognize the symptoms and levels of severity of depression. A pretest/posttest format was used to test knowledge (N = 42) about depression symptoms. Results showed that the participation improved the clergy's ability to recognize depression symptoms. Faith community nurses can develop workshops for clergy to improve recognition and treatment of depression. PMID:27610907

  9. Active surveillance of prostate cancer in African American men.

    PubMed

    Silberstein, Jonathan L; Feibus, Allison H; Maddox, Michael M; Abdel-Mageed, Asim B; Moparty, Krishnarao; Thomas, Raju; Sartor, Oliver

    2014-12-01

    Active surveillance (AS) is a treatment strategy for prostate cancer (PCa) whereby patients diagnosed with PCa undergo ongoing characterization of their disease with the intent of avoiding radical treatment. Previously, AS has been demonstrated to be a reasonable option for men with low-risk PCa, but existing cohorts largely consist of Caucasian Americans. Because African Americans have a greater incidence, more aggressive, and potentially more lethal PCa than Caucasian Americans, it is unclear if AS is appropriate for African Americans. We performed a review of the available literature on AS with a focus on African Americans.

  10. Discrimination, Mastery, and Depressive Symptoms Among African American Men

    PubMed Central

    Watkins, Daphne C.; Hudson, Darrell L.; Caldwell, Cleopatra Howard; Siefert, Kristine; Jackson, James S.

    2013-01-01

    Purpose This study examines the influence of discrimination and mastery on depressive symptoms for African American men at young (18–34), middle (35–54), and late (55+) adulthood. Method Analyses are based on responses from 1,271 African American men from the National Survey of American Life (NSAL). Results Discrimination was significantly related to depressive symptoms for men ages 35 to 54 and mastery was found to be protective against depressive symptoms for all men. Compared to African American men in the young and late adult groups, discrimination remained a statistically significant predictor of depressive symptoms for men in the middle group once mastery was included. Implications Findings demonstrate the distinct differences in the influence of discrimination on depressive symptoms among adult African American males and the need for future research that explores the correlates of mental health across age groups. Implications for social work research and practice with African American men are discussed. PMID:24436576

  11. Sex-biased gene flow in African Americans but not in American Caucasians.

    PubMed

    Gonçalves, V F; Prosdocimi, F; Santos, L S; Ortega, J M; Pena, S D J

    2007-01-01

    We have previously shown evidence of strong sex-biased genetic blending in the founding and ongoing history of the Brazilian population, with the African and Amerindian contribution being highest from maternal lineages (as measured by mitochondrial DNA) and the European contribution foremost from paternal lineages (estimated from Y-chromosome haplogroups). The same phenomenon has been observed in several other Latin American countries, suggesting that it might constitute a universal characteristic of the Iberian colonization of the Americas. However, it has also recently been detected in the Black population of the United States. We thus wondered if the same could be observed in American Caucasians. To answer that question, we retrieved 1387 hypervariable I Caucasian mitochondrial DNA sequences from the FBI population database and established their haplogroups and continental geographical sources. In sharp contrast with the situation of the Caucasian population of Latin American countries, only 3.1% of the American Caucasian sequences had African and/or Amerindian origin. To explain this discrepancy we propose that the finding of elevated genomic contributions from European males and Amerindian or African females depends not only on the occurrence of directional mating, but also on the "racial" categorization of the children born from these relations. In this respect, social practices in Latin America and in the United States diverge considerably; in the former socially significant "races" are normally designated according to physical appearance, while in the latter descent appears to be the most important factor. PMID:17573655

  12. Mitochondrial DNA diversity in the African American population

    PubMed Central

    Johnson, Derek C.; Shrestha, Sadeep; Wiener, Howard W.; Makowsky, Robert; Kurundkar, Ashish; Wilson, Craig M.; Aissani, Brahim

    2014-01-01

    Genetic polymorphism along mitochondrial DNA (mtDNA) defines population-specific signatures called mtDNA haplogroups. Estimation of mtDNA haplogroup distribution may be prone to errors, notably if the study sample is not drawn from a multicenter cohort. Here, we report on mtDNA diversity in a sample of African American individuals (n = 343) enrolled in a multicenter cohort. Sequencing of the hypervariable regions I and II of the D-loop control region showed that the most common mitochondrial variants are 73G, 146C, 150T, 152C, 189G, 16278T, and 16311C. In agreement with the published data, we observed 17 common mtDNA haplogroups: L0, L1, L1b, L1c, L2, L2a, L2b, L2c, L2e, L3, L3b, L3d, L3e, L3f, L3h, L3x, and L4. The most commonly observed haplogroup is L2a (19.8%), followed by L1b (10.2%). Overall, the observed mtDNA haplogroup distribution in our study is similar to those published for the African American and the African populations. PMID:24102597

  13. Africans and Black Americans in the United States: Social Distance and Differential Acculturation.

    ERIC Educational Resources Information Center

    Emoungu, Paul-Albert

    1992-01-01

    Presents an exploratory examination of the causes of social distance characterizing the association between Africans and African Americans. African American's perceptions about Africa and Africans are assessed through anecdotes and impressions, and thoughts and criticisms of Africans about African Americans are considered. A social science…

  14. Genetic Associations of PPARGC1A with Type 2 Diabetes: Differences among Populations with African Origins

    PubMed Central

    Cheema, Amanpreet K.; Li, Tan; Liuzzi, Juan P.; Zarini, Gustavo G.; Dorak, Mehmet T.; Huffman, Fatma G.

    2015-01-01

    The aim of this study was to assess the differences in correlation of PPARGC1A polymorphisms with type 2 diabetes (T2D) risk in adults of African origins: African Americans and Haitian Americans. The case-control study consisted of >30 years old, self-identified Haitian Americans (n = 110 cases and n = 116 controls) and African Americans (n = 124 cases and n = 122 controls) living in South Florida with and without T2D. Adjusted logistic regression indicated that both SNP rs7656250 (OR = 0.22, P = 0.005) and rs4235308 (OR = 0.42, P = 0.026) showed protective association with T2D in Haitian Americans. In African Americans, however, rs4235308 showed significant risk association with T2D (OR = 2.53, P = 0.028). After stratification with sex, in Haitian Americans, both rs4235308 (OR = 0.38, P = 0.026) and rs7656250 (OR = 0.23, P = 0.006) showed protective association with T2D in females whereas in African American males rs7656250 had statistically significant protective effect on T2D (OR = 0.37, P = 0.043). The trends observed for genetic association of PPARGC1A SNPs, rs4235308, and rs7656250 for T2D between Haitian Americans and African Americans point out differences in Black race and warrant replicative study with larger sample size. PMID:25977930

  15. Primary care for young African American men.

    PubMed

    Rich, J A

    2001-01-01

    Young African American men in the inner city have higher rates of mortality and morbidity from potentially preventable causes than other American men of the same age. They suffer disproportionately high rates of preventable illness from violence, sexually transmitted diseases, and HIV infection. These young men present with problems related to sexual concerns, mental health issues, substance abuse, and violence. They also report substantial risk-taking behaviors, including unprotected sex, substance use, and weapon carrying, as well as exposure to violence. Access to and use of preventive primary care services has been limited for these patients in the past because of financial barriers and competing social issues. Racism and historical oppression have created barriers of mistrust for young men of color. Factors that contribute to their adverse health status, as well as ways to address these problems, are discussed.

  16. Problems of Transition for African Students in an American University.

    ERIC Educational Resources Information Center

    Adelegan, Francis O.; Parks, David J.

    1985-01-01

    Surveyed Black East African, Black West African and Arabic North African students (N=33) enrolled in an American university to identify their problems and personal attributes and environmental conditions influencing their experience. Discusses social, transportation, food, loneliness, and other problems. (MCF)

  17. New insights on the risk for cardiovascular disease in African Americans: the role of added sugars.

    PubMed

    Saab, Karim R; Kendrick, Jessica; Yracheta, Joseph M; Lanaspa, Miguel A; Pollard, Maisha; Johnson, Richard J

    2015-02-01

    African Americans are at increased risk for cardiovascular and metabolic diseases, including obesity, high BP, diabetes, CKD, myocardial infarction, and stroke. Here we summarize the current risks and provide an overview of the underlying risk factors that may account for these associations. By reviewing the relationship between cardiovascular and renal diseases and the African-American population during the early 20th century, the historic and recent associations of African heritage with cardiovascular disease, and modern population genetics, it is possible to assemble strong hypotheses for the primary underlying mechanisms driving the increased frequency of disease in African Americans. Our studies suggest that underlying genetic mechanisms may be responsible for the increased frequency of high BP and kidney disease in African Americans, with particular emphasis on the role of APOL1 polymorphisms in causing kidney disease. In contrast, the Western diet, particularly the relatively high intake of fructose-containing sugars and sweetened beverages, appears to be the dominant force driving the increased risk of diabetes, obesity, and downstream complications. Given that intake of added sugars is a remediable risk factor, we recommend clinical trials to examine the reduction of sweetened beverages as a primary means for reducing cardiovascular risk in African Americans. PMID:25090991

  18. New Insights on the Risk for Cardiovascular Disease in African Americans: The Role of Added Sugars

    PubMed Central

    Saab, Karim R.; Kendrick, Jessica; Yracheta, Joseph M.; Lanaspa, Miguel A.; Pollard, Maisha

    2015-01-01

    African Americans are at increased risk for cardiovascular and metabolic diseases, including obesity, high BP, diabetes, CKD, myocardial infarction, and stroke. Here we summarize the current risks and provide an overview of the underlying risk factors that may account for these associations. By reviewing the relationship between cardiovascular and renal diseases and the African-American population during the early 20th century, the historic and recent associations of African heritage with cardiovascular disease, and modern population genetics, it is possible to assemble strong hypotheses for the primary underlying mechanisms driving the increased frequency of disease in African Americans. Our studies suggest that underlying genetic mechanisms may be responsible for the increased frequency of high BP and kidney disease in African Americans, with particular emphasis on the role of APOL1 polymorphisms in causing kidney disease. In contrast, the Western diet, particularly the relatively high intake of fructose-containing sugars and sweetened beverages, appears to be the dominant force driving the increased risk of diabetes, obesity, and downstream complications. Given that intake of added sugars is a remediable risk factor, we recommend clinical trials to examine the reduction of sweetened beverages as a primary means for reducing cardiovascular risk in African Americans. PMID:25090991

  19. Social Support Structures and African-American Marriages.

    ERIC Educational Resources Information Center

    Curry-El, Judith A.; And Others

    An issue currently facing the African-American community is the incidence of divorce, which is presently at a higher rate than that of other groups. This study focused on the supportive networks of African-American couples utilizing a network analysis approach to examine the relationship between the networks, and marital satisfaction among the…

  20. "Workin' on the Railroad": African American Labor History

    ERIC Educational Resources Information Center

    Maher, Rebecca

    2004-01-01

    In the spring of 2003, the author worked with a team of eighth grade teachers at Asheville Middle School in North Carolina on a project that combined fine art, music, the history of the railroads, and the African American experience in the state and nation. In her classroom, students interviewed a retired train conductor, who was African American,…

  1. Perceptions of Teacher Expectations by African American High School Students

    ERIC Educational Resources Information Center

    Pringle, Beverley E.; Lyons, James E.; Booker, Keonya C.

    2010-01-01

    African American high school students are performing behind their White classmates regardless of whether they are in majority or minority populations at school. Teacher expectations, among school-related factors that can impact the academic achievement of African American high school students, are the focus of this study. Interviews were conducted…

  2. Perceived Racism as a Predictor of Paranoia among African Americans

    ERIC Educational Resources Information Center

    Combs, Dennis R.; Penn, David L.; Cassisi, Jeffrey; Michael, Chris; Wood, Terry; Wanner, Jill; Adams, Scott

    2006-01-01

    Recent theoretical models suggest that perceived racism acts as a stressor for African Americans and may be associated with a variety of negative psychological consequences, notably paranoia. Paranoia among African Americans is believed to reflect the lower end of the paranoia continuum based on experiences with racism. Thus, it may be beneficial…

  3. Resiliency Instructional Tactics: African American Students with Learning Disabilities

    ERIC Educational Resources Information Center

    Jones, Vita L.

    2011-01-01

    Schools and classrooms, if well conceived, can serve as protective environments for the positive development of African American students with learning disabilities (LD) (Keogh & Weisner, 1993). Many African American students who lack resiliency often struggle with life's challenges and may be predisposed to negative outcomes in life, so the focus…

  4. The African American Family and AIDS: Counseling Issues and Strategies.

    ERIC Educational Resources Information Center

    Rowe, Patrick; Beamish, Patricia M.

    This document discusses the application of a systems approach for family counseling for African American families with a family member infected with Acquired Immune Deficiency Syndrome (AIDS). It begins by citing statistics that illustrate that there exists a disproportionate representation of cases of AIDS among African Americans. A discussion on…

  5. African Americans' Access to Vocational Rehabilitation Services after Antidiscrimination Legislation

    ERIC Educational Resources Information Center

    Mwachofi, Ari K.

    2008-01-01

    The purpose of this study was to determine changes in African Americans' access to occasional rehabilitation (VR) services subsequent to landmark legislative and judicial antidiscrimination provisions of the mid-20th century. This study compared African American VR access before the antidiscrimination legislation in 1937 and after the legislation…

  6. The Classroom and the Community: African American Youth Speak Out.

    ERIC Educational Resources Information Center

    Clardy, Pauline; Cole-Robinson, Cynthia; Jones, Terrence O'C.; Michie, Gregory

    In studying urban schools, researchers have identified several critical curriculum issues related to the miseducation and alienation of African American students. This paper looks at three such issues: the disconnection between the school curriculum and African American students' cultural backgrounds and environments (e.g., black dialect versus…

  7. African Americans Who Teach German Language and Culture.

    ERIC Educational Resources Information Center

    Fikes, Robert Jr.

    2001-01-01

    A large number of black scholars have pursued advanced degrees in the German language, history, and culture. Describes the history of African American interest in the German language and culture, highlighting various black scholars who have studied German over the years. Presents data on African Americans in German graduate programs and examines…

  8. African American English: Implications for School Counseling Professionals

    ERIC Educational Resources Information Center

    Day-Vines, Norma L.; Barto, Heather H.; Booker, Beverly L.; Smith, Kim V.; Barna, Jennifer; Maiden, Brian S.; Zegley, Linda; Felder, Monique T.

    2009-01-01

    African American English (AAE) refers to the systematic, rule-governed linguistic patterns of found among African Americans. This article provides an overview of AAE. More specifically, the article enumerates the historical underpinnings associated with AAE, identifies a representative set of AAE characteristics, reviews relevant research, and…

  9. Race Consciousness. African-American Studies for the New Century.

    ERIC Educational Resources Information Center

    Fossett, Judith Jackson, Ed.; Tucker, Jeffrey A., Ed.

    This collection of essays represents new scholarship in African American studies, drawing lessons from the past and providing insights into current intellectual trends. Topics such as the culture of America as a culture of race, legacies of slavery and colonialism, crime and welfare politics, and African American cultural studies are addressed.…

  10. Higher Education and the Early Education of African American Ministers

    ERIC Educational Resources Information Center

    Cooks, Michael

    2010-01-01

    The education of African American ministers in the United States has been little researched. Numerous books address the profession of ministry and the education of Blacks in general, but most do not specifically address issues pertaining to the professional education of Black ministers. The majority of the hurdles African Americans faced were…

  11. Perceived Racism and Encouragement among African American Adults

    ERIC Educational Resources Information Center

    Rowles, Joanna; Duan, Changming

    2012-01-01

    Racial discrimination has negatively affected African Americans in the United States for centuries and produced one of the most publicly recognized histories of social oppression. Extensive research has shown the deleterious effects of racism on African American people and clearly demonstrated that perceived racism and discrimination may…

  12. Boys into Men: Raising Our African American Teenage Sons.

    ERIC Educational Resources Information Center

    Boyd-Franklin, Nancy; Franklin, A. J.

    This guide to rearing African American boys offers simple and effective strategies for problem-solving, improving communication, and instilling a positive racial identity. The book draws on strong African American family values and cultural and spiritual strengths. The chapters are: (1) "You Must Act As If It Is Impossible To Fail: Challenges in…

  13. African-American Students' Expectations about Counseling: A Comparative Investigation.

    ERIC Educational Resources Information Center

    Kemp, Arthur D.

    1994-01-01

    Compared African American college students' counseling expectations at two universities with different racial majorities. The type of university attended exerted the most powerful effect on counseling expectations of subjects. Counseling professionals must help African American students fully understand issues such as confidentiality, privacy, and…

  14. A Rationale for Creating African-American Immersion Schools.

    ERIC Educational Resources Information Center

    Holt, Kenneth C.

    1991-01-01

    The traditional U.S. classroom's milieu has distorted and refused to recognize the language and cultural richness of African-American students. Milwaukee's two immersion schools, Victor Berger Elementary School and Parkman Middle School, place the African-American students and their culture at the center of the educational process. Results have…

  15. African American History as Depicted in Recently Published Children's Books

    ERIC Educational Resources Information Center

    Lamme, Linda Leonard; Astengo, Be; Lowery, Ruth McCoy; Masla, Diane; Russo, Roseanne; Savage, Debbie; Shelton, Nancy Rankie

    2002-01-01

    Exciting stories about African Americans in recently published historical fiction books for children concern Pea Island Life-Station, a private school for African American girls, a biracial slave, a black woman who homesteads for land in 1889, and an orphan who travels on his own to Flint, Michigan, during the Depression. Much of this history…

  16. Clustering of Risk Behaviours among African American Adults

    ERIC Educational Resources Information Center

    Baruth, M.; Addy, C. L.; Wilcox, S.; Dowda, M.

    2012-01-01

    Objectives: Individuals may engage in more than one risk behaviour at any given time. The extent to which risk behaviours cluster among African American adults has been largely unexplored. This study examined the prevalence and clustering of three risk behaviours among African American church members: smoking; low moderate-to-vigorous intensity…

  17. The Guide for Choosing African American Parenting Curricula.

    ERIC Educational Resources Information Center

    Wingo, Robin R.; Mertensmeyer, Carol

    This guide is designed to help professionals working with African American parents to be better prepared to select culturally sensitive materials, to program more effectively, and to draw from the richness within the African American culture. The guide is one in a series of culturally specific guides produced as part of ParentLink's Review of…

  18. Enriching Inclusive Learning: African Americans in Historic Costume

    ERIC Educational Resources Information Center

    Ratute, Ashley; Marcketti, Sara B.

    2009-01-01

    Educating students to embrace diversity and value all people is a core value of educators in family and consumer sciences (FCS). For instructors in FCS, integrating the contributions of African Americans--particularly in textiles and clothing--can be an inclusive learning opportunity. The authors compiled resources on African Americans and…

  19. African American English: An Interview with Marcyliena Morgan.

    ERIC Educational Resources Information Center

    Rymes, Betsy

    1995-01-01

    Discusses an interview in which Marcyliena Morgan elaborates on the necessity to analyze both microlinguistic issues of grammar and phonology as well as larger issues of discourse pragmatics and language ideology. The interview touches on African American poetry, the convergence of African American and standard English, and oases and indirectness.…

  20. 20 African-Americans Your Students Should Meet

    ERIC Educational Resources Information Center

    Bardeen, Tara

    2008-01-01

    There is more to Black History Month than honoring Martin Luther King Jr. Black History Month is a time to honor the significant contributions of African-Americans throughout history. This article presents 20 super-achievers new generation of African-Americans heroes students should meet: (1) Kimberly Oliver; (2) John Lewis; (3) Rita Dove; (4)…

  1. Effective Education of African American Exceptional Learners: New Perspectives.

    ERIC Educational Resources Information Center

    Ford, Bridgie Alexis, Ed.; And Others

    This book presents 11 author-contributed papers covering the theory and practice of effective assessment and instruction of African American students with exceptionalities, including both disabilities and giftedness. Emphasis is on effective delivery of empowering services to African American youth and their families. The first seven papers have…

  2. Serving African American Children: Child Welfare Perspectives Series.

    ERIC Educational Resources Information Center

    Jackson, Sondra, Ed.; Brissett-Chapman, Sheryl, Ed.

    This collection brings together articles by African American authors who are committed to research, policies, and programs affecting African American children and families. The articles are grouped into sections on policy, research, and practice issues; clinical techniques and treatment models; and new perspectives in child welfare. The following…

  3. A Profile of Bereavement Supports in African American Church Congregations.

    ERIC Educational Resources Information Center

    Moore, Penelope J.; Hazell, LaVone V.; Honeyghan, Edna M.

    Bereavement educators, counselors, clergy, and other specialists have observed that African Americans tend to under-utilize end-of-life palliative care services and general bereavement resources. The literature suggests that involving clergy in outreach to the African American community may be a viable strategy for developing bereavement supports.…

  4. African American Homeschooling and the Question of Curricular Cultural Relevance

    ERIC Educational Resources Information Center

    Mazama, Ama; Lundy, Garvey

    2013-01-01

    Homeschooling, and academic interest in this phenomenon, have increased tremendously over the last decade. The surge of African American involvement in the homeschool movement has also become noticeable. However, there continues to be a general paucity of research on the motivations of African American parents that choose homeschooling. In order…

  5. Social Achievement Goals: Validation among Rural African American Adolescents

    ERIC Educational Resources Information Center

    Jones, Martin H.; Mueller, Christian E.; Royal, Kenneth D.; Shim, Sungok Serena; Hart, Caroline O.

    2013-01-01

    Little extant research attempts to understand why rural African Americans engage in social relationships with peers in school. This is somewhat surprising as rural students' peer interactions often affect their scholastic desires, and peers can alter African Americans' academic performance. Hence, the current study examined both the…

  6. Interaction of African American Learners Online: An Adult Education Perspective

    ERIC Educational Resources Information Center

    Kang, Haijun; Yang, Yang

    2016-01-01

    This study examines how various life factors and personal attributes affect African American adult learners' use of the three types of learning interaction-learner-content, learner-instructor, and learner-learner. Multivariate multiple regression analyses were used. The aggregate effect of life factors on African American adult learners' use of…

  7. Designing Effective Library Services for African American Youth

    ERIC Educational Resources Information Center

    Hughes-Hassell, Sandra

    2013-01-01

    President Obama signed the "White House Initiative on Educational Excellence for African Americans" on July 26, 2012. This executive order recognizes that many "African Americans lack equal access to highly effective teachers and principals, safe schools, and challenging college preparatory classes, and disproportionately experience…

  8. Asthma Management Disparities: A Photovoice Investigation with African American Youth

    ERIC Educational Resources Information Center

    Evans-Agnew, Robin

    2016-01-01

    Disparities in asthma management are a burden on African American youth. The objective of this study is to describe and compare the discourses of asthma management disparities (AMDs) in African American adolescents in Seattle to existing youth-related asthma policies in Washington State. Adolescents participated in a three-session photovoice…

  9. The Relationship between African American Enculturation and Racial Identity

    ERIC Educational Resources Information Center

    Cokley, Kevin; Helm, Katherine

    2007-01-01

    This study investigated how predictive the Cross Racial Identity Scale (CRIS; B. J. Vandiver, W. E. Cross, F. C. Worrell, & P. Fhagen-Smith, 2002), a measure of Black racial identity, was of African American cultural practices, beliefs, and attitudes (i.e., enculturation) as measured by the African American Acculturation Scale-33 (H. Landrine & E.…

  10. Psychosocial Correlates of Smoking Trajectories Among Urban African American Adolescents

    ERIC Educational Resources Information Center

    Fergus, Stevenson; Zimmerman, Marc A.; Caldwell, Cleopatra H.

    2005-01-01

    Little is known of smoking trajectories or of the correlates of smoking trajectories among African American youth. Ninth-grade African American adolescents (n = 566) were interviewed in Year 1 and then were subsequently interviewed annually for 3 additional years. Five trajectories of cigarette smokers were identified: abstainers,…

  11. Judgement Accuracy in Body Preferences among African Americans.

    ERIC Educational Resources Information Center

    Patel, Kushal A.; Gray, James J.

    2001-01-01

    Examined whether African Americans accurately estimated levels of thinness preferred by the opposite gender. College students rated pictures of figures approximating their current figure, their ideal figure, the figure most likely to attract the opposite gender, and the opposite gender figure they found most attractive. African American women…

  12. Support Needs of Overweight African American Women for Weight Loss

    ERIC Educational Resources Information Center

    Thomas, Janet L.; Stewart, Diana W.; Lynam, Ian M.; Daley, Christine M.; Befort, Christie; Scherber, Robyn M.; Mercurio, Andrea E.; Okuyemi, Kolawole S.; Ahluwalia, Jasjit S.

    2009-01-01

    Objectives: To examine social support needs of obese and overweight African American women for weight loss. Methods: Focus groups were conducted with overweight and obese African American women. Data were analyzed using standard grounded theory text analysis. Results: Our middle-aged (45.7 years; SD = 12.6) women (N = 66) were interested in…

  13. Stalling Out: The Relative Progress of African Americans.

    ERIC Educational Resources Information Center

    Tidwell, Billy J.

    The socioeconomic progress of African Americans appears to be in a stalled state. This study analyzes the progress of African Americans toward parity with Whites over a 15- to 20-year period in the following areas: (1) employment; (2) economic development; (3) education; (4) health; (5) housing; and (6) political empowerment. For individual…

  14. Food Group Categories of Low-Income African American Women

    ERIC Educational Resources Information Center

    Lynch, Elizabeth B.; Holmes, Shane

    2011-01-01

    Objective: Describe lay food group categories of low-income African American women and assess the overlap of lay food groups and MyPyramid food groups. Design: A convenience sample of African American mothers from a low-income Chicago neighborhood performed a card-sorting task in which they grouped familiar food items into food groups. Setting:…

  15. Parental Attachments and Psychological Distress among African American College Students

    ERIC Educational Resources Information Center

    Love, Keisha McGhee

    2008-01-01

    African American college students attending predominately White institutions often encounter stressors that their Caucasian peers do not experience. Because of these unique stressors, African American students are more prone to experience psychological distress. Identifying factors that counteract psychological distress among these students is…

  16. Brother to Brother: Success for African-American Males

    ERIC Educational Resources Information Center

    Henningsen, Stephanie

    2005-01-01

    This article discusses Brother to Brother, a program designed to help African-American men stay in college and graduate. St. Petersburg College formed this program seven years ago as a means not only of recruiting male African-American students, but also to identify issues that cause them to be at risk for dropping out and to use retention…

  17. Beyond Statistics: African American Male Persistence in Community College

    ERIC Educational Resources Information Center

    Dickens, Manuel Dewayne

    2012-01-01

    The purpose of this qualitative case study that consists of six African American male participants is to examine, describe, and analyze African American male persistence factors at a community college in the midwest of the United States. The study uses qualitative content analysis as a research method that provides a systematic and objective means…

  18. African Americans Respond Poorly to Hepatitis C Treatment

    ERIC Educational Resources Information Center

    Black Issues in Higher Education, 2004

    2004-01-01

    African Americans have a significantly lower response rate to treatment for chronic hepatitis C than non-Hispanic Whites, according to a new study led by Duke University Medical Center researchers. Some African Americans--19 percent--did respond to the drug combination of peginterferon alfa-2b and ribavirin. But in non-Hispanic Whites with the…

  19. A Snapshot of African Americans in Higher Education. Mini Brief

    ERIC Educational Resources Information Center

    Institute for Higher Education Policy, 2010

    2010-01-01

    In recognition of national African-American History Month, the Institute for Higher Education Policy wishes to highlight the trends and present-day experiences of African-American college students. Recognizing that the society benefits tremendously from an educated citizenry, there must be a renewed commitment to ensuring educational opportunity,…

  20. African-American Press Coverage of Clarence Thomas Nomination.

    ERIC Educational Resources Information Center

    Fearn-Banks, Kathleen

    1994-01-01

    Examines pressures facing the African American press by focusing on its coverage of the 1991 nomination of Clarence Thomas to the United States Supreme Court. Discusses the dilemma these newspapers faced in choosing between supporting African Americans and supporting civil rights, with their mixed coverage of the story reflecting this dilemma. (SR)

  1. African-American Grandmothers as Health Educators in the Family

    ERIC Educational Resources Information Center

    Watson, Jeffrey A.; Randolph, Suzanne M.; Lyons, James L.

    2005-01-01

    More than 18,000 adolescents die each year in the United States from bicycle, motorcycle, car, and truck accidents. This study sought to understand the role of African-American grandmothers as prevention-oriented health educators in the family. Full Model Fitted Regression Analyses were conducted on a sample of African-American grandmothers (N =…

  2. The Struggle of African American Students in the Public Schools

    ERIC Educational Resources Information Center

    Mubenga, Pascal

    2006-01-01

    The long road of slavery from generation to generation has left a legacy in the mind of African American students that has impacted their achievements in schools. In this project, the struggle of African American students in the public school education will be analyzed from the historical standpoint of view and its impact on their achievements.…

  3. African American College Students: Establishing HIV Prevention Programs.

    ERIC Educational Resources Information Center

    Duncan, Cecil

    African American college students are among the age group of African Americans who are at significantly higher risk for heterosexual transmission of human immunodeficiency virus (HIV). Much of the research in this area suggests that for the majority of these students, there is little or no relationship between the knowledge of HIV transmission and…

  4. Patterns of Violent Behavior and Victimization among African American Youth.

    ERIC Educational Resources Information Center

    McGee, Zina T.

    1999-01-01

    Reviews types of reported problems among African American youth exposed to violence and victimization. A substantial number of African American youth reported being exposed to direct victimization while in transit to and from school. Discusses the impact of violence on mental health status, in that subjects exposed to violence exhibited…

  5. Experiences of African American Empowerment: A Jamesian Perspective on Agency

    ERIC Educational Resources Information Center

    Curtis-Tweed, Phyllis

    2003-01-01

    This essay draws from the work of William James and three African American pragmatists, W.E.B. Du Bois, Ralph Ellison and Cornel West, to explore the moral relevance of the self as an empowered agent among African American youth. The focus is on Jamesian agency as a function of the individual's awareness of options in context, the self-empowerment…

  6. Academic Achievement and the Third Grade African American Male

    ERIC Educational Resources Information Center

    Shropshire, Delia F. B.

    2013-01-01

    The purpose of the study was to determine to what extent teaching style relates to third grade African American male academic achievement. The problem in this study addressed the factors affecting the academic achievement of the African American third grade male. This problem led the researcher to investigate the teaching styles of the…

  7. Counseling African American Clients: Professional Counselors and Religious Institutions

    ERIC Educational Resources Information Center

    Ennis, Willie, Jr.; Ennis, Willie, III; Durodoye, Beth A.; Ennis-Cole, Demetria; Bolden, Vernie L.

    2004-01-01

    In this article the authors describe a model counseling ministry within an African American church and discuss how the larger body of professional counselors can interface with similar programs and institutions that are a source of strength for many African Americans. Implications of the model for professional counselors are also discussed. The…

  8. African-American College Students' Perceptions Of Sexual Coercion

    ERIC Educational Resources Information Center

    Mouzon, LaTonya D.; Battle, Alicia; Clark, Kevin P.; Coleman, Stephanie; Ogletree, Roberta J.

    2005-01-01

    While the phenomenon of sexual coercion has been studied extensively, little is known about African-American college students' perceptions about verbal sexual coercion. Using a phenomenological approach, the researchers conducted five focus group interviews with 39 African-American students (20 females, 19 males) at a large Midwestern university…

  9. Indigenous Systems within the African-American Community

    ERIC Educational Resources Information Center

    Marbley, Aretha Faye; Rouson, Leon

    2011-01-01

    For the African-American family, life ain't been no crystal stair. The African-American family has trotted for over 400 years through a wilderness of racism, poverty, discrimination of all kinds, crossing seas of monsters and forests of demons. Yet, despite the numerous obstacles and attacks that society has mounted against it since slavery, the…

  10. "Teaching while Black": Narratives of African American Student Affairs Faculty

    ERIC Educational Resources Information Center

    Patton, Lori D.; Catching, Christopher

    2009-01-01

    African American faculty have historically been underrepresented within predominantly white institutions (PWIs) and deal with academic isolation, marginalization of their scholarship, and racial hostility. Little is known about the experiences of African American faculty who teach in student affairs graduate programs. The purpose of this study was…

  11. Raising African American Student Achievement: California Goals, Local Outcomes

    ERIC Educational Resources Information Center

    EdSource, 2008

    2008-01-01

    Although academic performance is a concern, African American students represent less than 8 percent of California's K-12 students, and at times get lost in California policy debates about improving student performance. Findings of this study indicate that: (1) California's African American students are concentrated in relatively few counties and…

  12. Culturally Competent Counseling for Religious and Spiritual African American Adolescents

    ERIC Educational Resources Information Center

    Moore-Thomas, Cheryl; Day-Vines, Norma L.

    2008-01-01

    Religion and spirituality are deeply rooted in traditional African American culture. Data suggest that African American adolescents maintain higher baseline rates of religious activities and beliefs than their peers (Bachman, Johnston, & O'Malley, 2005; Smith, Faris, Denton, & Regnerus, 2003). Recognizing these data, this article examines…

  13. Lessons Learned: Research within an Urban, African American District

    ERIC Educational Resources Information Center

    Scott, Kimberly Ann

    2012-01-01

    For an African American female researcher whose race, class, and gender work as oppressive intersecting units shaping my contextualized experiences, meaning-making, and self-definition, the implications of my work with African American communities are complicated. In this article, I draw on culturally sensitive research practices, critical race…

  14. Dimensions of Academic Contingencies among African American College Students

    ERIC Educational Resources Information Center

    Griffin, Tiffany Monique; Chavous, Tabbye; Cogburn, Courtney; Branch, LaToya; Sellers, Robert

    2012-01-01

    Drawing from existing literature, the authors conceptualized a two-dimensional framework of African American students' academic contingencies of self-worth. The results from exploratory and confirmatory factor analyses with a sample of African American college freshmen (N = 330) supported this prediction. Self-Worth Dependent academic…

  15. Perceived value in food selection when dining out: comparison of African Americans and Euro-Americans.

    PubMed

    Vinci, Debra M; Philipp, Steven F

    2007-06-01

    This descriptive study compares African Americans' and Euro-Americans' perceived value of food selection pertaining to cost, portion size, and meal satisfaction when eating away from home. A stratified sample was drawn from a southern U.S. metropolitan area (N= 1,011; 486 African American, 525 Euro-American). Analysis showed no difference between African-American and Euro-American adults by sex or how often they dined out. These two groups significantly differed across years of education, age, and answering 14 of 18 rated statements on value perceptions. African-Americans' value perceptions were influenced more by lower cost foods and larger portion sizes than those of Euro-Americans. For meal satisfaction, African Americans were more likely to agree with statements that indicate preferring foods high in energy and low in essential micronutrient density. This study supports the need for more investigation.

  16. Horizontal and vertical dimensions of individualism-collectivism: a comparison of African Americans and European Americans.

    PubMed

    Komarraju, Meera; Cokley, Kevin O

    2008-10-01

    The current study examined ethnic differences in horizontal and vertical dimensions of individualism and collectivism among 96 African American and 149 European American college students. Participants completed the 32-item Singelis et al. (1995) Individualism/Collectivism Scale. Multivariate analyses of variance results yielded a main effect for ethnicity, with African Americans being significantly higher on horizontal individualism and European Americans being higher on horizontal collectivism and vertical individualism. A moderated multiple regression analysis indicated that ethnicity significantly moderated the relationship between individualism and collectivism. Individualism and collectivism were significantly and positively associated among African Americans, but not associated among European Americans. In addition, collectivism was related to grade point average for African Americans but not for European Americans. Contrary to the prevailing view of individualism-collectivism being unipolar, orthogonal dimensions, results provide support for individualism-collectivism to be considered as unipolar, related dimensions for African Americans.

  17. African-American caregivers' breast health behavior.

    PubMed

    Inoue, Megumi; Pickard, Joseph G; Welch-Saleeby, Patricia; Johnson, Sharon

    2009-10-01

    This study utilizes a stress and coping framework which includes cognitive appraisal, personal and environmental resources, coping and stress to examine factors related to African-American caregivers' breast cancer screenings, including mammograms, clinical examinations and self-examinations. Using data from the Black Rural and Urban Caregivers Mental Health and Functioning Study, we performed separate logistic regressions for each type of breast cancer screening. Results reveal that having a regular doctor checkup (coping), care recipients having a cancer diagnosis (cognitive appraisal, and living in urban areas (environment resources) are associated with receiving a mammogram. Having greater income, having at least a high school degree (both personal resources) and having a regular doctor checkup (coping) are associated with receiving a clinical examination. Increased caregiver strain (stress), being 40 years old or older, social support (coping) and living in rural areas are associated with performing a self-examination. Targeting African-American caregivers, particularly in rural areas, for increased education on the importance of receiving breast cancer screenings is crucial to addressing health disparities. Making resources available, encouraging caregivers to get a clinical examination and a mammogram and directing public education toward caregivers are important points of intervention.

  18. Correlates of African American Men's Sexual Schemas

    PubMed Central

    Morales, Dawn A.; Coyne-Beasley, Tamera; St. Lawrence, Janet

    2013-01-01

    Sexual schemas are cognitive representations of oneself as a sexual being and aid in the processing of sexually relevant information. We examined the relationship between sociosexuality (attitudes about casual sex), masculine ideology (attitudes toward traditional men and male roles), and cultural centrality (strength of identity with racial group) as significant psychosocial and sociocultural predictors in shaping young, heterosexual African American men's sexual schemas. A community sample (n=133) of men in a southeastern city of the United States completed quantitative self-report measures examining their attitudes and behavior related to casual sex, beliefs about masculinity, racial and cultural identity, and self-views of various sexual aspects of themselves. Results indicated that masculine ideology and cultural centrality were both positively related to men's sexual schemas. Cultural centrality explained 12 % of the variance in level of sexual schema, and had the strongest correlation of the predictor variables with sexual schema (r=.36). The need for more attention to the bidirectional relationships between masculinity, racial/cultural identity, and sexual schemas in prevention, intervention, and public health efforts for African American men is discussed. PMID:24031118

  19. Physical activity participation in African American churches.

    PubMed

    Bopp, Melissa; Wilcox, Sara; Laken, Marilyn; McClorin, Lottie

    2009-01-01

    The potential benefit of physical activity (PA) programs delivered through churches is largely unexamined. This study examined availability of PA programs, interpersonal support for PA, and PA participation in African-American churches. Individuals from a random sample of 20 churches in South Carolina participated in a telephone survey (N = 571). Forty two percent of respondents reported PA programs at their churches. Walking programs (20%), aerobics (22%) or a combination of both (20%) were most common. Respondents who reported having these programs were more likely to meet PA recommendations than those who did not (p = 0.05). Larger churches were more likely to offer PA programs (p = 0.02) than small or medium sized churches. Only 24% of respondents had spoken with the health director at their church about participating in a PA program, and only 25% and 33% had ever spoken with another church member about a PA program or were encouraged to join a PA program, respectively. Individuals with more interpersonal support from other church members for PA were significantly more likely to meet PA recommendations (p = 0.01). This study indicates that program and interpersonal supports within African American churches may offer a venue for increasing PA among members.

  20. Training African-American residents in the 20th century.

    PubMed

    Green-McKenzie, Judith

    2004-03-01

    Bellevue Hospital, the oldest public hospital in the United States and a lineal descendant of an infirmary for slaves, accepted its first African-American resident, Dr. Ubert Conrad Vincent, in 1918. This occurred at a time when many medical centers were not accepting African-American residents. At the end of WWII, one-third of the accredited medical schools still barred African Americans. However, Bellevue Hospital continued to train African-American residents. Between the 1920s and 1940s four African Americans matriculated at Bellevue Hospital. There were six in the 1950s, four in the 1960s, and 25 in the 1970s. By the 1980s, 40 African Americans matriculated, and between 1990 and 1995, 61 matriculated. Despite its historic first, Bellevue lagged slightly behind the national average. While the number of African-American residents occupying U.S. residency slots increased from 2.8% in 1978 to 6.5% in 1996, African Americans comprised 3.6% of residency slots at Bellevue between 1985-1995. Currently, only 7% of practicing physicians and 5% in faculty positions are latino, African-American, and Native American. Increasing the number of under-represented minority (URM) physicians is important to the United States, as URM physicians are more likely to serve the poor and uninsured, therefore improving the overall healthcare of the underprivileged. A study by the Association of American Medical Colleges indicated that minority medical school graduates were five times more likely to report that they planned to serve minority populations than other graduates. In their position paper, the American College of Physicians expressed the belief that increasing the number of URM physicians will help reduce healthcare disparities that can hurt minority populations and lead to poor health outcomes. The Supreme Court acknowledged the importance of racial diversity by upholding the University of Michigan affirmative action admissions policy in its June 2003 ruling. URM physicians are

  1. An African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African Americans.

    PubMed

    Kelley, James M; Hughes, Laura B; Faggard, Jeffrey D; Danila, Maria I; Crawford, Monica H; Edberg, Yuanqing; Padilla, Miguel A; Tiwari, Hemant K; Westfall, Andrew O; Alarcón, Graciela S; Conn, Doyt L; Jonas, Beth L; Callahan, Leigh F; Smith, Edwin A; Brasington, Richard D; Allison, David B; Kimberly, Robert P; Moreland, Larry W; Edberg, Jeffrey C; Bridges, S Louis

    2009-03-01

    Cytotoxic T-lymphocyte associated protein 4 (CTLA4) is a negative regulator of T-cell proliferation. Polymorphisms in CTLA4 have been inconsistently associated with susceptibility to rheumatoid arthritis (RA) in populations of European ancestry but have not been examined in African Americans. The prevalence of RA in most populations of European and Asian ancestry is approximately 1.0%; RA is purportedly less common in black Africans, with little known about its prevalence in African Americans. We sought to determine if CTLA4 polymorphisms are associated with RA in African Americans. We performed a 2-stage analysis of 12 haplotype tagging single nucleotide polymorphisms (SNPs) across CTLA4 in a total of 505 African American RA patients and 712 African American controls using Illumina and TaqMan platforms. The minor allele (G) of the rs231778 SNP was 0.054 in RA patients, compared to 0.209 in controls (4.462 x 10(-26), Fisher's exact). The presence of the G allele was associated with a substantially reduced odds ratio (OR) of having RA (AG+GG genotypes vs. AA genotype, OR 0.19, 95% CI: 0.13-0.26, p = 2.4 x 10(-28), Fisher's exact), suggesting a protective effect. This SNP is polymorphic in the African population (minor allele frequency [MAF] 0.09 in the Yoruba population), but is very rare in other groups (MAF = 0.002 in 530 Caucasians genotyped for this study). Markers associated with RA in populations of European ancestry (rs3087243 [+60C/T] and rs231775 [+49A/G]) were not replicated in African Americans. We found no confounding of association for rs231778 after stratifying for the HLA-DRB1 shared epitope, presence of anti-cyclic citrullinated peptide antibody, or degree of admixture from the European population. An African ancestry-specific genetic variant of CTLA4 appears to be associated with protection from RA in African Americans. This finding may explain, in part, the relatively low prevalence of RA in black African populations.

  2. Africans in the American Labor Market.

    PubMed

    Elo, Irma T; Frankenberg, Elizabeth; Gansey, Romeo; Thomas, Duncan

    2015-10-01

    The number of migrants to the United States from Africa has grown exponentially since the 1930s. For the first time in America's history, migrants born in Africa are growing at a faster rate than migrants from any other continent. The composition of African-origin migrants has also changed dramatically: in the mid-twentieth century, the majority were white and came from only three countries; but today, about one-fifth are white, and African-origin migrants hail from across the entire continent. Little is known about the implications of these changes for their labor market outcomes in the United States. Using the 2000-2011 waves of the American Community Survey, we present a picture of enormous heterogeneity in labor market participation, sectoral choice, and hourly earnings of male and female migrants by country of birth, race, age at arrival in the United States, and human capital. For example, controlling a rich set of human capital and demographic characteristics, some migrants-such as those from South Africa/Zimbabwe and Cape Verde, who typically enter on employment visas-earn substantial premiums relative to other African-origin migrants. These premiums are especially large among males who arrived after age 18. In contrast, other migrants-such as those from Sudan/Somalia, who arrived more recently, mostly as refugees-earn substantially less than migrants from other African countries. Understanding the mechanisms generating the heterogeneity in these outcomes-including levels of socioeconomic development, language, culture, and quality of education in countries of origin, as well as selectivity of those who migrate-figures prominently among important unresolved research questions. PMID:26304845

  3. Africans in the American Labor Market.

    PubMed

    Elo, Irma T; Frankenberg, Elizabeth; Gansey, Romeo; Thomas, Duncan

    2015-10-01

    The number of migrants to the United States from Africa has grown exponentially since the 1930s. For the first time in America's history, migrants born in Africa are growing at a faster rate than migrants from any other continent. The composition of African-origin migrants has also changed dramatically: in the mid-twentieth century, the majority were white and came from only three countries; but today, about one-fifth are white, and African-origin migrants hail from across the entire continent. Little is known about the implications of these changes for their labor market outcomes in the United States. Using the 2000-2011 waves of the American Community Survey, we present a picture of enormous heterogeneity in labor market participation, sectoral choice, and hourly earnings of male and female migrants by country of birth, race, age at arrival in the United States, and human capital. For example, controlling a rich set of human capital and demographic characteristics, some migrants-such as those from South Africa/Zimbabwe and Cape Verde, who typically enter on employment visas-earn substantial premiums relative to other African-origin migrants. These premiums are especially large among males who arrived after age 18. In contrast, other migrants-such as those from Sudan/Somalia, who arrived more recently, mostly as refugees-earn substantially less than migrants from other African countries. Understanding the mechanisms generating the heterogeneity in these outcomes-including levels of socioeconomic development, language, culture, and quality of education in countries of origin, as well as selectivity of those who migrate-figures prominently among important unresolved research questions.

  4. Africans in the American Labor Market

    PubMed Central

    Elo, Irma T.; Frankenberg, Elizabeth; Gansey, Romeo; Thomas, Duncan

    2015-01-01

    The number of migrants to the United States from Africa has grown exponentially since the 1930s. For the first time in America’s history, migrants born in Africa are growing at a faster rate than migrants from any other continent. The composition of African-origin migrants has also changed dramatically: in the mid-twentieth century, the majority were white and came from only three countries; but today, about one-fifth are white, and African-origin migrants hail from across the entire continent. Little is known about the implications of these changes for their labor market outcomes in the United States. Using the 2000–2011 waves of the American Community Survey, we present a picture of enormous heterogeneity in labor market participation, sectoral choice, and hourly earnings of male and female migrants by country of birth, race, age at arrival in the United States, and human capital. For example, controlling a rich set of human capital and demographic characteristics, some migrants—such as those from South Africa/Zimbabwe and Cape Verde, who typically enter on employment visas—earn substantial premiums relative to other African-origin migrants. These premiums are especially large among males who arrived after age 18. In contrast, other migrants—such as those from Sudan/Somalia, who arrived more recently, mostly as refugees—earn substantially less than migrants from other African countries. Understanding the mechanisms generating the heterogeneity in these outcomes—including levels of socioeconomic development, language, culture, and quality of education in countries of origin, as well as selectivity of those who migrate—remain important unresolved research questions. PMID:26304845

  5. Tenancy and African American Marriage in the Postbellum South.

    PubMed

    Bloome, Deirdre; Muller, Christopher

    2015-10-01

    The pervasiveness of tenancy in the postbellum South had countervailing effects on marriage between African Americans. Tenancy placed severe constraints on African American women's ability to find independent agricultural work. Freedwomen confronted not only planters' reluctance to contract directly with women but also whites' refusal to sell land to African Americans. Marriage consequently became one of African American women's few viable routes into the agricultural labor market. We find that the more counties relied on tenant farming, the more common was marriage among their youngest and oldest African American residents. However, many freedwomen resented their subordinate status within tenant marriages. Thus, we find that tenancy contributed to union dissolution as well as union formation among freedpeople. Microdata tracing individuals' marital transitions are consistent with these county-level results.

  6. Tenancy and African American Marriage in the Postbellum South

    PubMed Central

    Bloome, Deirdre; Muller, Christopher

    2015-01-01

    The pervasiveness of tenancy in the postbellum South had countervailing effects on marriage between African Americans. Tenancy placed severe constraints on African American women’s ability to find independent agricultural work. Freedwomen confronted not only planters’ reluctance to contract directly with women but also whites’ refusal to sell land to African Americans. Marriage consequently became one of African American women’s few viable routes into the agricultural labor market. We find that the more counties relied on tenant farming, the more common was marriage among their youngest and oldest African American residents. However, many freedwomen resented their subordinate status within tenant marriages. Thus, we find that tenancy contributed to union dissolution as well as union formation among freedpeople. Microdata tracing individuals’ marital transitions are consistent with these county-level results. PMID:26223562

  7. Hypertension in African Americans and its related chronic diseases.

    PubMed

    Moulton, Sandra A

    2009-01-01

    Hypertension is prevalent in African Americans and it is associated with three chronic diseases namely; stroke, kidney disease, and heart disease. The literature examines the prevalence of hypertension in African Americans in relation to other groups. Not only do African Americans have higher rates of organ damage, but also stroke and heart disease mortality caused, at least in part, by hypertension. Health professionals, especially nurses, should be proactive in detecting hypertension in African Americans and be more aggressive in controlling and treating this high-risk group. Health education regarding the dangers of hypertension should be the primary focus of healthcare professionals to decrease and prevent mortality and morbidity in the African Americans with hypertension.

  8. Chronic Pain in Older African American Grandparent Caregivers.

    PubMed

    Booker, Staja Q

    2016-06-01

    African American grandparent caregiving is increasing, and evidence shows that grandparent caregiving influences health and its management. As older adults age, their potential of experiencing chronic pain increases, and this is profound given that physiological research shows that African Americans, aside from aging, may have a predisposition for developing chronic pain. Research shows older African Americans experience significant chronic pain, but few have discussed the implications of managing chronic pain in older African Americans who have added parental responsibility. Many older African Americans receive home healthcare services and there is a unique role for home healthcare clinicians in caring for this vulnerable population. This article discusses the impact of pain on caregiving, challenges in pain management, and practice and policy implications to assist home healthcare clinicians maintain the safety and protection of both the older grandparent and grandchildren. PMID:27243429

  9. African Americans, hypertension and the renin angiotensin system

    PubMed Central

    Williams, Sandra F; Nicholas, Susanne B; Vaziri, Nosratola D; Norris, Keith C

    2014-01-01

    African Americans have exceptionally high rates of hypertension and hypertension related complications. It is commonly reported that the blood pressure lowering efficacy of renin angiotensin system (RAS) inhibitors is attenuated in African Americans due to a greater likelihood of having a low renin profile. Therefore these agents are often not recommended as initial therapy in African Americans with hypertension. However, the high prevalence of comorbid conditions, such as diabetes, cardiovascular and chronic kidney disease makes treatment with RAS inhibitors more compelling. Despite lower circulating renin levels and a less significant fall in blood pressure in response to RAS inhibitors in African Americans, numerous clinical trials support the efficacy of RAS inhibitors to improve clinical outcomes in this population, especially in those with hypertension and risk factors for cardiovascular and related diseases. Here, we discuss the rationale of RAS blockade as part of a comprehensive approach to attenuate the high rates of premature morbidity and mortality associated with hypertension among African Americans. PMID:25276290

  10. Culturally specific dance to reduce obesity in African American women.

    PubMed

    Murrock, Carolyn J; Gary, Faye A

    2010-07-01

    This article provides evidence of a culturally specific dance intervention to decrease obesity as measured by body fat and body mass index (BMI) in African American women. A community partnership was formed with two African American churches to develop an intervention to address the issue of obesity. The culturally specific dance intervention was delivered two times per week for 8 weeks, choreographed to gospel music selected by the experimental group participants, and taught by an African American woman. Body fat and BMI were assessed at three time points and revealed significant differences between the two groups. Attending a minimum of 7 classes was enough to show an observed dose effect and the intervention was found to be culturally specific by understanding their roles as African American women. This community partnership was an effective way to promote a church-based, culturally specific dance intervention to improve the health of African American women. PMID:19098267

  11. Culturally Specific Dance to Reduce Obesity in African American Women

    PubMed Central

    Murrock, Carolyn J.; Gary, Faye A.

    2013-01-01

    This article provides evidence of a culturally specific dance intervention to decrease obesity as measured by body fat and body mass index (BMI) in African American women. A community partnership was formed with two African American churches to develop an intervention to address the issue of obesity. The culturally specific dance intervention was delivered two times per week for 8 weeks, choreographed to gospel music selected by the experimental group participants, and taught by an African American woman. Body fat and BMI were assessed at three time points and revealed significant differences between the two groups. Attending a minimum of 7 classes was enough to show an observed dose effect and the intervention was found to be culturally specific by understanding their roles as African American women. This community partnership was an effective way to promote a church-based, culturally specific dance intervention to improve the health of African American women. PMID:19098267

  12. Tenancy and African American Marriage in the Postbellum South.

    PubMed

    Bloome, Deirdre; Muller, Christopher

    2015-10-01

    The pervasiveness of tenancy in the postbellum South had countervailing effects on marriage between African Americans. Tenancy placed severe constraints on African American women's ability to find independent agricultural work. Freedwomen confronted not only planters' reluctance to contract directly with women but also whites' refusal to sell land to African Americans. Marriage consequently became one of African American women's few viable routes into the agricultural labor market. We find that the more counties relied on tenant farming, the more common was marriage among their youngest and oldest African American residents. However, many freedwomen resented their subordinate status within tenant marriages. Thus, we find that tenancy contributed to union dissolution as well as union formation among freedpeople. Microdata tracing individuals' marital transitions are consistent with these county-level results. PMID:26223562

  13. The Impact of Stress on the Life History Strategies of African American Adolescents: Cognitions, Genetic Moderation, and the Role of Discrimination

    PubMed Central

    Gibbons, Frederick X.; Roberts, Megan E.; Gerrard, Meg; Li, Zhigang; Beach, Steven R. H.; Simons, Ronald L.; Weng, Chih-Yuan; Philibert, Robert A.

    2013-01-01

    The impact of three different sources of stress—environmental, familial (e.g., low parental investment), and interpersonal (i.e., racial discrimination)—on the life history strategies (LHS) and associated cognitions of African American adolescents were examined over an 11-year period (five waves, from age 10.5 to 21.5). Analyses indicated that each one of the sources of stress was associated with faster LHS cognitions (e.g., tolerance of deviance, willingness to engage in risky sex), which, in turn, predicted faster LHS behaviors (e.g., frequent sexual behavior). LHS then negatively predicted outcome (resilience) at age 21.5; i.e., faster LHS → less resilience. In addition, presence of the risk (“sensitivity”) alleles of two monoamine-regulating genes, the serotonin transporter gene (5HTTLPR) and the dopamine D4 receptor gene (DRD4) moderated the impact of perceived racial discrimination on LHS cognitions: Participants with more risk alleles (higher “sensitivity”) reported: faster LHS cognitions at age 18 and less resilience at age 21, if they had experienced higher amounts of discrimination ; and slower LHS and more resilience if they had experienced smaller amounts of discrimination. Implications for LHS theories are discussed. PMID:22251000

  14. Implicit Stereotyping and Medical Decisions: Unconscious Stereotype Activation in Practitioners' Thoughts About African Americans

    PubMed Central

    Stone, Jeff; Childs, Amanda

    2012-01-01

    Objectives. We investigated whether stereotypes unconsciously influence the thinking and behavior of physicians, as they have been shown to do in other professional settings, such as among law enforcement personnel and teachers. Methods. We conducted 2 studies to examine whether stereotypes are implicitly activated in physicians. Study 1 assessed what diseases and treatments doctors associate with African Americans. Study 2 presented these (and control terms) to doctors as part of a computerized task. Subliminal images of African American and White men appeared prior to each word, and reaction times to words were recorded. Results. When primed with an African American face, doctors reacted more quickly for stereotypical diseases, indicating an implicit association of certain diseases with African Americans. These comprised not only diseases African Americans are genetically predisposed to, but also conditions and social behaviors with no biological association (e.g., obesity, drug abuse). Conclusions. We found implicit stereotyping among physicians; faces they never consciously saw altered performance. This suggests that diagnoses and treatment of African American patients may be biased, even in the absence of the practitioner's intent or awareness. PMID:22420815

  15. The Role of African American-Owned Radio in Health Promotion: Community Service Projects Targeting Young African American Males.

    ERIC Educational Resources Information Center

    Johnson, Phylis; Birk, Thomas A.

    1993-01-01

    Surveys African-American-owned radio stations to determine how effective they are in addressing health issues among African Americans. Responses from more than 50 stations indicate that they serve as change agents by encouraging community partnerships and emphasizing drug awareness, nonviolent behavior, education, and other health issues. (SLD)

  16. Conceptualizing the African American Mathematics Teacher as a Key Figure in the African American Education Historical Narrative

    ERIC Educational Resources Information Center

    Clark, Lawrence M.; Jones Frank, Toya; Davis, Julius

    2013-01-01

    Background/Context: Historians and researchers have documented and explored the work and role of African American teachers in the U.S. educational system, yet there has been limited attention to the specific work, role, and experiences of African American mathematics teachers. To meaningfully and responsibly conceptualize the role of African…

  17. African American Male Achievement: Using a Tenet of Critical Theory to Explain the African American Male Achievement Disparity

    ERIC Educational Resources Information Center

    Palmer, Robert T.; Maramba, Dina C.

    2011-01-01

    Although African Americans continue to demonstrate a desire for education, Black male enrollment and completion rates in higher education are dismal when compared to other ethnic groups. Researchers and scholars have noted various theories and philosophies responsible for the academic disengagement of African American men in higher education. This…

  18. Relationships among obesity, inflammation, and insulin resistance in African Americans and West Africans.

    PubMed

    Doumatey, Ayo P; Lashley, Kerrie S; Huang, Hanxia; Zhou, Jie; Chen, Guanjie; Amoah, Albert; Agyenim-Boateng, Kofi; Oli, Johnnie; Fasanmade, Olufemi; Adebamowo, Clement A; Adeyemo, Adebowale A; Rotimi, Charles N

    2010-03-01

    Several research studies in different populations indicate that inflammation may be the link between obesity and insulin resistance (IR). However, this relationship has not been adequately explored among African Americans, an ethnic group with disproportionately high rates of obesity and IR. In this study, we conducted a comparative study of the relationship among adiposity, inflammation, and IR in African Americans and West Africans, the ancestral source population for African Americans. The associations between obesity markers (BMI and waist-to-hip ratio (WHR)), inflammatory markers (high-sensitivity C-reactive protein (hsCRP), haptoglobin, interleukin (IL)-6, and tumor necrosis factor (TNF)-alpha), and IR (homeostasis model assessment of insulin resistance (HOMA(IR))) were evaluated in 247 West Africans and 315 African Americans. In average, African Americans were heavier than the West Africans (by an average of 1.6 BMI units for women and 3 BMI units for men). Plasma hsCRP, haptoglobin, and IL-6 (but not TNF-alpha level) were higher in African Americans than in West Africans. In both populations, BMI was associated with markers of inflammation and with HOMA(IR), and these associations remained significant after adjusting for sex and age. However, the pattern of associations between measured inflammatory markers and IR was different between the two groups. In West Africans, hsCRP was the only inflammatory marker associated with IR. In contrast, hsCRP, haptoglobin, and IL-6 were all associated with IR in African Americans. Interestingly, none of the associations between markers of inflammation and IR remained significant after adjusting for BMI. This finding suggests that in African Americans, the relationship between inflammatory markers and IR is mediated by adiposity.

  19. An ImmunoChip study of multiple sclerosis risk in African Americans.

    PubMed

    Isobe, Noriko; Madireddy, Lohith; Khankhanian, Pouya; Matsushita, Takuya; Caillier, Stacy J; Moré, Jayaji M; Gourraud, Pierre-Antoine; McCauley, Jacob L; Beecham, Ashley H; Piccio, Laura; Herbert, Joseph; Khan, Omar; Cohen, Jeffrey; Stone, Lael; Santaniello, Adam; Cree, Bruce A C; Onengut-Gumuscu, Suna; Rich, Stephen S; Hauser, Stephen L; Sawcer, Stephen; Oksenberg, Jorge R

    2015-06-01

    The aims of this study were: (i) to determine to what degree multiple sclerosis-associated loci discovered in European populations also influence susceptibility in African Americans; (ii) to assess the extent to which the unique linkage disequilibrium patterns in African Americans can contribute to localizing the functionally relevant regions or genes; and (iii) to search for novel African American multiple sclerosis-associated loci. Using the ImmunoChip custom array we genotyped 803 African American cases with multiple sclerosis and 1516 African American control subjects at 130 135 autosomal single nucleotide polymorphisms. We conducted association analysis with rigorous adjustments for population stratification and admixture. Of the 110 non-major histocompatibility complex multiple sclerosis-associated variants identified in Europeans, 96 passed stringent quality control in our African American data set and of these, >70% (69) showed over-representation of the same allele amongst cases, including 21 with nominally significant evidence for association (one-tailed test P < 0.05). At a further eight loci we found nominally significant association with an alternate correlated risk-tagging single nucleotide polymorphism from the same region. Outside the regions known to be associated in Europeans, we found seven potentially associated novel candidate multiple sclerosis variants (P < 10(-4)), one of which (rs2702180) also showed nominally significant evidence for association (one-tailed test P = 0.034) in an independent second cohort of 620 African American cases and 1565 control subjects. However, none of these novel associations reached genome-wide significance (combined P = 6.3 × 10(-5)). Our data demonstrate substantial overlap between African American and European multiple sclerosis variants, indicating common genetic contributions to multiple sclerosis risk.

  20. An ImmunoChip study of multiple sclerosis risk in African Americans

    PubMed Central

    Isobe, Noriko; Madireddy, Lohith; Khankhanian, Pouya; Matsushita, Takuya; Caillier, Stacy J.; Moré, Jayaji M.; Gourraud, Pierre-Antoine; McCauley, Jacob L.; Beecham, Ashley H.; Piccio, Laura; Herbert, Joseph; Khan, Omar; Cohen, Jeffrey; Stone, Lael; Santaniello, Adam; Cree, Bruce A. C.; Onengut-Gumuscu, Suna; Rich, Stephen S.; Hauser, Stephen L.; Sawcer, Stephen

    2015-01-01

    The aims of this study were: (i) to determine to what degree multiple sclerosis-associated loci discovered in European populations also influence susceptibility in African Americans; (ii) to assess the extent to which the unique linkage disequilibrium patterns in African Americans can contribute to localizing the functionally relevant regions or genes; and (iii) to search for novel African American multiple sclerosis-associated loci. Using the ImmunoChip custom array we genotyped 803 African American cases with multiple sclerosis and 1516 African American control subjects at 130 135 autosomal single nucleotide polymorphisms. We conducted association analysis with rigorous adjustments for population stratification and admixture. Of the 110 non-major histocompatibility complex multiple sclerosis-associated variants identified in Europeans, 96 passed stringent quality control in our African American data set and of these, >70% (69) showed over-representation of the same allele amongst cases, including 21 with nominally significant evidence for association (one-tailed test P < 0.05). At a further eight loci we found nominally significant association with an alternate correlated risk-tagging single nucleotide polymorphism from the same region. Outside the regions known to be associated in Europeans, we found seven potentially associated novel candidate multiple sclerosis variants (P < 10−4), one of which (rs2702180) also showed nominally significant evidence for association (one-tailed test P = 0.034) in an independent second cohort of 620 African American cases and 1565 control subjects. However, none of these novel associations reached genome-wide significance (combined P = 6.3 × 10−5). Our data demonstrate substantial overlap between African American and European multiple sclerosis variants, indicating common genetic contributions to multiple sclerosis risk. PMID:25818868

  1. African ancestry, lung function and the effect of genetics

    PubMed Central

    Wehrmeister, Fernando C.; Hartwig, Fernando P.; Perez-Padilla, Rogelio; Gigante, Denise P.; Barros, Fernando C.; Oliveira, Isabel O.; Ferreira, Gustavo D.; Horta, Bernardo L.

    2015-01-01

    African-Americans have smaller lung function compared with European-Americans. The aim of this study was to disentangle the contribution of genetics from other variables on lung function. A cohort was followed from birth to 30 years of age in Brazil. Several variables were collected: genomic analysis based on DNA; forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) obtained by spirometry; height measured by anthropometrists; and thorax circumference evaluated by photonic scanner. Crude and adjusted linear regression models were calculated according to African ancestry. The sample comprised 2869 participants out of 3701 members of the cohort. Males with higher African ancestry by DNA analysis had a smaller FEV1 (−0.13 L, 95% CI −0.23– −0.03 L) and FVC (−0.21 L, 95% CI −0.32– −0.09 L) compared with those with less African ancestry, having accounted for height, sitting to standing height ratio and other confounders. Similar effects were seen in females. After adjustment, ancestry remained significantly associated with lung function, but the large effect of adjustment for confounding among males (but not females) does not allow us to exclude the possibility that residual confounding may still account for these findings. PMID:25700383

  2. Attachment Style Differences and Depression in African American and European American College Women: Normative Adaptations?

    ERIC Educational Resources Information Center

    Cooley, Eileen L.; Garcia, Amber L.

    2012-01-01

    This study examined ethnic differences in attachment styles and depression among African American and European American college women. African American women reported less favorable views of others, which suggests that attachment styles emphasizing caution in relationships may be normative and adaptive for these women. There were no differences…

  3. HLA disease association and protection in HIV infection among African Americans and Caucasians.

    PubMed

    Cruse, J M; Brackin, M N; Lewis, R E; Meeks, W; Nolan, R; Brackin, B

    1991-01-01

    In a previous investigation, we demonstrated an increased progression of overt AIDS in the African American population compared to the Caucasian population as reflected by the significantly lower absolute number of CD4+ lymphocytes detected in the African American population in an earlier study. The present study elucidates some of the possible genetic factors which may contribute to disease association or protection against HIV infection. The HLA phenotypes expressed as A, B, C, DR and DQw antigens were revealed by the Amos-modified typing procedure. NIH scoring was utilized to designate positive cells taking up trypan blue. A test of proportion equivalent to the chi 2 approximation was used to compare the disease population (n = 62; 38 African Americans, 24 Caucasians) to race-matched normal heterosexual local controls (323 African Americans, 412 Caucasians). Significant p values were corrected for the number of HLA antigens tested. HLA markers associated with possible protection from infection for African Americans were Cw4 and DRw6, whereas Caucasians expressed none. Disease association markers present in the African American population were A31, B35, Cw6, Cw7, DR5, DR6, DRw11, DRw12, DQw6 and DQw7, whereas in the Caucasian population A28, Aw66, Aw48, Bw65, Bw70, Cw7, DRw10, DRw12, DQw6 and DQw7 were demonstrated. The highest phenotypic frequency for a disease association marker in the study was for HLA-DR5 (62.9%) in the HIV-infected African American population without Kaposi's sarcoma compared to a frequency of 28.9% for the regional control group (p = 0.0012). We conclude that genetic factors do have a role in HIV infection since only 50-60% of those exposed to the AIDS virus will become infected. PMID:1910527

  4. Racism and hypertension among African Americans.

    PubMed

    Peters, Rosalind M

    2004-10-01

    The purpose of this study was to examine the relationship of racism and blood pressure (BP). Participants were 162 urban African American adults. Measurements included the Racism and Life Experiences Scale, Krieger Racial Discrimination Questionnaire, State-Trait Personality Inventory (anxiety and depression), State-Trait Anger Expression Inventory, and automated measures of BP. Correlational and multiple regression analyses were done to examine relationships among key variables, t tests and ANOVA tested group differences by age, gender, and racism category. There was a high prevalence of perceived racism, which was not associated with higher BP. The racism/BP relationship was moderated by age with significant age related differences noted. Older participants (40 years or older) experienced more distress from racism, more anger suppression, and higher BP but lower levels of stress emotions. The highest levels of BP were noted in older adults reporting the lowest level of perceived racism, raising the issue of "internalized oppression."

  5. Genetic variation in CYP4A11 and blood pressure response to mineralocorticoid receptor antagonism or ENaC inhibition: an exploratory pilot study in African Americans.

    PubMed

    Laffer, Cheryl L; Elijovich, Fernando; Eckert, George J; Tu, Wanzhu; Pratt, J Howard; Brown, Nancy J

    2014-07-01

    An rs3890011 variant of CYP4A11, which is in linkage disequilibrium with the loss-of-function variant rs1126742, is associated with hypertension in humans. In mice, Cyp4a deficiency results in salt-sensitive hypertension through activation of ENaC. We tested the hypothesis that the rs3890011 variant is associated with blood pressure response to drugs acting via the ENaC pathway. African Americans with volume-dependent, resistant hypertension were randomized to treatment with placebo, spironolactone, amiloride, or combination. Blood pressure responses were analyzed by CYP4A11 genotypes. Rs3890011 (GG:GC:CC = 20:35:28) and rs1126742 (TT:TC:CC = 45:31:7) were in linkage disequilibrium (D' = 1, r = 0.561). Expected small number of rs1126742 CC homozygotes precluded analysis of the effect of this genotype on treatment responses. Spironolactone reduced blood pressure in rs3890011 GG and GC individuals, but not in CC homozygotes (P = .002), whereas amiloride reduced blood pressure similarly in all rs3890011 genotypes. The antihypertensive effects of spironolactone and amiloride were comparable in GG and GC participants, but only amiloride reduced pressure in CC homozygotes (-6.3 ± 7.3/-3.2 ± 4.0 vs. +6.8 ± 7.9/+4.8 ± 8.6 mm Hg, P < .01/<.05). The aldosterone response to spironolactone was also blunted in the CC genotype. In individuals homozygous for the CYP4A11 rs3890011 C allele, blood pressure is resistant to mineralocorticoid receptor antagonism, but sensitive to ENaC inhibition, consistent with ENaC activation. Studies in a larger population are needed to replicate these findings. PMID:25064769

  6. Common Variation in Vitamin D Pathway Genes Predicts Circulating 25-Hydroxyvitamin D Levels among African Americans

    PubMed Central

    Signorello, Lisa B.; Shi, Jiajun; Cai, Qiuyin; Zheng, Wei; Williams, Scott M.; Long, Jirong; Cohen, Sarah S.; Li, Guoliang; Hollis, Bruce W.; Smith, Jeffrey R.; Blot, William J.

    2011-01-01

    Vitamin D is implicated in a wide range of health outcomes, and although environmental predictors of vitamin D levels are known, the genetic drivers of vitamin D status remain to be clarified. African Americans are a group at particularly high risk for vitamin D insufficiency but to date have been virtually absent from studies of genetic predictors of circulating vitamin D levels. Within the Southern Community Cohort Study, we investigated the association between 94 single nucleotide polymorphisms (SNPs) in five vitamin D pathway genes (GC, VDR, CYP2R1, CYP24A1, CYP27B1) and serum 25-hydroxyvitamin D (25(OH)D) levels among 379 African American and 379 Caucasian participants. We found statistically significant associations with three SNPs (rs2298849 and rs2282679 in the GC gene, and rs10877012 in the CYP27B1 gene), although only for African Americans. A genotype score, representing the number of risk alleles across the three SNPs, alone accounted for 4.6% of the variation in serum vitamin D among African Americans. A genotype score of 5 (vs. 1) was also associated with a 7.1 ng/mL reduction in serum 25(OH)D levels and a six-fold risk of vitamin D insufficiency (<20 ng/mL) (odds ratio 6.0, p = 0.01) among African Americans. With African ancestry determined from a panel of 276 ancestry informative SNPs, we found that high risk genotypes did not cluster among those with higher African ancestry. This study is one of the first to investigate common genetic variation in relation to vitamin D levels in African Americans, and the first to evaluate how vitamin D-associated genotypes vary in relation to African ancestry. These results suggest that further evaluation of genetic contributors to vitamin D status among African Americans may help provide insights regarding racial health disparities or enable the identification of subgroups especially in need of vitamin D-related interventions. PMID:22205958

  7. Diagnosis of fragile X syndrome: a qualitative study of African American families.

    PubMed

    Visootsak, Jeannie; Charen, Krista; Rohr, Julia; Allen, Emily; Sherman, Stephanie

    2012-12-01

    Fragile X syndrome (FXS) is an inherited genetic condition with critical consequences to the proband and family members at all levels in the generations. Although evidence demonstrates that the rates of diagnosis for FXS are the same in all racial groups, age of diagnosis in African American children has been reported to occur later than in Caucasian children. Additionally, African American families are seriously under-represented in existing FXS research studies. As such, it is important to understand the possible disparities in the underlying factors to receiving a diagnosis in African American families with FXS. Herein, a qualitative approach was adopted to describe the overall FXS diagnosis experiences (pre-diagnosis, diagnosis, and post-diagnosis stages) of a convenience sample of 10 African American mothers. We identified three major findings among our participants: (1) FXS testing is not ordered immediately once a parent expresses concerns of developmental delays to the pediatricians, (2) the diagnosis is sometimes delivered in an insensitive manner with information often being outdated and unbalanced towards negative aspects, (3) communication issues among family members exists once the diagnosis is discovered. Although these qualitative data may not be representative of the whole group, these findings have significant implications for genetic counseling and our understanding in providing support and advocacy for African American families with FXS.

  8. Parenting Needs of Urban, African American Fathers.

    PubMed

    Smith, Tyler K; Tandon, S Darius; Bair-Merritt, Megan H; Hanson, Janice L

    2015-07-01

    Fathers play a critical role in children's development; similarly, fatherhood positively affects men's health. Among the larger population of fathers relatively little is known about the parenting knowledge of urban, African American fathers. Focusing on urban, African American fathers, the objectives of this study were to (1) understand the primary sources from which fathers learn about parenting, (2) determine where and how fathers prefer to receive future parenting education, and (3) explore the information perceived as most valuable to fathers and how this compares with the recommended anticipatory guidance (Bright Futures-based) delivered during well visits. Five focus groups, with a total of 21 participants, were conducted with urban fathers at a community-based organization. Study eligibility included being more than 18 years old, English speaking, and having at least one child 0 to 5 years old. During the focus groups, fathers were asked where they received parenting information, how and where they preferred to receive parenting information, and what they thought about Bright Futures parenting guidelines. Fathers most commonly described receiving parenting information from their own relatives rather than from their child's health care provider. Most fathers preferred to learn parenting from a person rather than a technology-based source and expressed interest in learning more about parenting at community-based locations. Although fathers viewed health care providers' role as primarily teaching about physical health, they valued Bright Futures anticipatory guidance about parenting. Fathers valued learning about child rearing, health, and development. Augmenting physician counseling about Bright Futures with community-based parenting education may be beneficial for fathers.

  9. Attention-deficit/hyperactivity disorder in African American youth.

    PubMed

    Bailey, Rahn K; Ali, Shahid; Jabeen, Shagufta; Akpudo, Hilary; Avenido, Jaymie U; Bailey, Theresa; Lyons, Jessica; Whitehead, Amelia A

    2010-10-01

    This article examines attention-deficit/hyperactivity disorder (ADHD) in African American youth. Tackling the myths and misinformation surrounding ADHD in the African American community can be one of the most difficult issues in mental illness circles. There is a lot of conflicting information about how African Americans are diagnosed, examined, and treated. This article clarifies some of the misconceptions and offers some comprehensibility to the issue of ADHD in African American youth. The incidence of ADHD is probably similar in African Americans and Caucasians. However, fewer African Americans are diagnosed with and treated for ADHD. That reality flies in the face of some perceptions in many African American communities. Reasons for this disparity have not been fully clarified and are most likely complex and numerous. Some barriers to treatment are driven by the beliefs of patients and their families, while others are the result of limitations in the health care system. Patient-driven obstacles to care include inadequate knowledge of symptoms, treatment, and consequences of untreated ADHD and fear of overdiagnosis and misdiagnosis. System-driven limitations include a lack of culturally competent health care providers, stereotyping or biases, and failure of clinicians to evaluate the child in multiple settings before diagnosis. PMID:20697849

  10. The Relationship between Pain, Disability, and Sex in African Americans.

    PubMed

    Walker, Janiece L; Thorpe, Roland J; Harrison, Tracie C; Baker, Tamara A; Cary, Michael; Szanton, Sarah L; Allaire, Jason C; Whitfield, Keith E

    2016-10-01

    Older African Americans consistently report diminished capacities to perform activities of daily living (ADL) compared with other racial groups. The extent to which bodily pain is related to declining abilities to perform ADL/ADL disability in African Americans remains unclear, as does whether this relationship exists to the same degree in African American men and women. For nurses to provide optimal care for older African Americans, a better understanding of the relationship between bodily pain and ADL disability and how it may differ by sex is needed. The aim of this study was to examine whether pain, age, education, income, marital status and/or comorbid conditions were associated with ADL disabilities in older African American women and men. This was a cross-sectional descriptive study. The sample included 598 participants (446 women, 152 men) from the first wave of the Baltimore Study on Black Aging. African American women (odds ratio [OR] = 4.06; 95% confidence interval [CI] 2.63-6.26) and African American men (OR = 6.44; 95% CI = 2.84-14.57) who reported bodily pain had greater ADL disability than those who did not report bodily pain. Having two or more comorbid conditions also was significantly associated with ADL disability in African American women (OR = 3.95; 95% CI: 2.09-7.47). Further work is needed to understand pain differences between older African American women and men to develop interventions that can be tailored to meet the individual pain needs of both groups.

  11. Under the shadow of Tuskegee: African Americans and health care.

    PubMed Central

    Gamble, V N

    1997-01-01

    The Tuskegee Syphilis Study continues to cast its long shadow on the contemporary relationship between African Americans and the biomedical community. Numerous reports have argued that the Tuskegee Syphilis Study is the most important reason why many African Americans distrust the institutions of medicine and public health. Such an interpretation neglects a critical historical point: the mistrust predated public revelations about the Tuskegee study. This paper places the syphilis study within a broader historical and social context to demonstrate that several factors have influenced--and continue to influence--African American's attitudes toward the biomedical community. PMID:9366634

  12. Support Needs of Overweight African American Women for Weight Loss

    PubMed Central

    Thomas, Janet L.; Stewart, Diana W.; Lynam, Ian M.; Daley, Christine M.; Befort, Christie; Scherber, Robyn M.; Mercurio, Andrea E.; Okuyemi, Kolawole S.; Ahluwalia, Jasjit S.

    2014-01-01

    Objectives To examine social support needs of obese and over-weight African American women for weight loss. Methods Focus groups were conducted with over-weight and obese African American women. Data were analyzed using standard grounded theory text analysis. Results Our middle-aged (45.7 years; SD=12.6) women (N = 66) were interested in receiving support from others focused on the health benefits of weight loss. Behaviors perceived as supportive include co-participating in exercise, providing nutrition education, using positive reinforcements, and avoiding criticism. Conclusions: African American women are interested in a program designed to increase social support for their weight loss. PMID:19182980

  13. Factors That Contribute to Learning Difference among African American and Caucasian Students.

    ERIC Educational Resources Information Center

    White, Stephen Earl

    This report examines the learning styles of Caucasian and African-American students. While research supports the claim that low academic achievement is prevalent in the minority community, there is no consensus regarding the causes. There are two schools of thought that involve (1) the cognitive deficit or genetic cause, and (2) the cultural…

  14. Is No Child Left Behind "Wise Schooling" for African American Male Students?

    ERIC Educational Resources Information Center

    McMillian, M. Monique

    2004-01-01

    To improve achievement among African American students, education professionals must pay special attention to African American male achievement and reframe the academic achievement gap as a treatment gap. Engagement studies suggest that African American students, and African American boys in particular, are susceptible to academic disengagement.…

  15. African American Culture and Heritage in Higher Education Research and Practice.

    ERIC Educational Resources Information Center

    Freeman, Kassie, Ed.

    Fifteen papers examine the cultural context and history of African Americans in higher education research and practice. Papers are grouped in three parts: African American culture in higher education research; African American higher education research issues and paradigms; and African American culture and higher education policy and practice.…

  16. The English History of African American English. Language and Society Series; 28.

    ERIC Educational Resources Information Center

    Poplack, Shana, Ed.

    Essays on the history of African American Vernacular English (AAVE) include: an introduction to the evolution of AAVE within the African American diaspora (Shana Poplack); "Rephrasing the Copula: Contraction and Zero in Early African American English" (James A. Walker); "Reconstructing the Source of Early African American English Plural Marking: A…

  17. Incremental impact of breast cancer SNP panel on risk classification in a screening population of white and African American women

    PubMed Central

    McCarthy, Anne Marie; Armstrong, Katrina; Handorf, Elizabeth; Jones, Marisa; Chen, Jinbo; Demeter, Mirar Bristol; McGuire, Erin; Conant, Emily F; Domchek, Susan M

    2014-01-01

    Breast cancer risk prediction remains imperfect, particularly among non-white populations. This study examines the impact of including single nucleotide polymorphism (SNP) alleles in risk prediction for white and African American women undergoing screening mammogram. Using a prospective cohort study, standard risk information and buccal swabs were collected at the time of screening mammography. A 12 SNP panel was performed by deCODE Genetics. Five-year and lifetime risks incorporating SNPs were calculated by multiplying estimated Breast Cancer Risk Assessment Tool (BCRAT) risk by the total genetic risk ratio. Concordance between the BCRAT and the Combined Model (BCRAT + SNPs) in identifying high-risk women was measured using the kappa statistic. SNP data were available for 813 women (39% African American, 55% white). The mean BCRAT 5-year risk was 1.70% for whites and 1.19% for African Americans. Mean genetic risk ratios were 1.10 in whites and 1.29 in African Americans. Among whites, three SNPs had higher frequencies, and among African Americans, seven SNPs had higher and four had lower high-risk allele frequencies than previously reported. Agreement between the BCRAT and the Combined Model was relatively low for identifying high-risk women (5-year κ=0.53, lifetime κ=0.37). Addition of SNPs had the greatest effect among African Americans, with 13% identified as having high 5-year risk by BCRAT, but 33% by the Combined Model. A greater proportion of African Americans were reclassified as having high 5-year risk than whites using the Combined Model (21% vs. 10%). The addition of SNPs to the BCRAT reclassifies the high-risk status of some women undergoing screening mammography, particularly African Americans. Further research is needed to determine the clinical validity and utility of the SNP panel for use in breast cancer risk prediction, particularly among African Americans for whom these risk alleles have generally not been validated. PMID:23474973

  18. Cultural variation in the social organization of problem solving among African American and European American siblings.

    PubMed

    Budak, Daniel; Chavajay, Pablo

    2012-07-01

    This study examined the social organization of a problem-solving task among 15 African American and 15 European American sibling pairs. The 30 sibling pairs between the ages of 6 and 12 were video recorded constructing a marble track together during a home visit. African American siblings were observed to collaborate more often than European American siblings who were more likely to divide up the labor and direct each other in constructing the marble track. In addition, older European American siblings made more proposals of step plans than older African American siblings. The findings provide insights into the cultural basis of the social organization of problem solving across African American and European American siblings. PMID:22686140

  19. Differences among African Americans and Euro-Americans in reasons for sports participation.

    PubMed

    Philipp, Steven F; Brezina, Sherie

    2002-08-01

    Findings from 829 respondents from the southern United States (323 African American, 506 Euro-American adults) in 64 nonschool leisure locations participating in 19 different sports showed that the African American and Euro-American groups differed significantly on the importance given to 2 of 6 reasons offered for their sports participation, "socializing with others" and "improving skills." Both reasons were rated as of greater importance by African-American respondents. These findings have implications for designing, marketing, and evaluating adult sports opportunities.

  20. The Peoples Multicultural Almanac: America from the 1400s to Present. 365 Days of Contributions by African Americans, Asian Americans, Hispanic Americans, Native Americans, European Americans.

    ERIC Educational Resources Information Center

    Taylor, Earl J., Jr.; And Others

    The Peoples Multicultural Almanac provides five entries for each day in the school year, September through May, organized for the following ethnic groups: (1) African Americans; (2) Asian Americans; (3) European Americans; (4) Hispanic Americans; and (5) Native Americans. The entries highlight significant social, political, historical, cultural,…

  1. Genetic Research and Native American Cultural Issues

    NASA Astrophysics Data System (ADS)

    Romero, Francine; Bemis, Lynne T.; Burhansstipanov, Linda; Dignan, Mark

    Cultural issues relevant to genetic education and research arc the focus of a new and innovative curriculum being developed for Native American college students and health professionals. Genetic Education for Native Americans (GENA) is funded by the National Human Genome Research Institute of the National Institutes of Health. The goal of the GENA project is to provide a balance of scientific and cultural information about genetic research, genetic testing, and careers in genetics for Native American students. This article describes issues related to the implementation of GENA and provides an example of an innovative approach to teaching about genetic research among Native American populations.

  2. Changing psychiatric perception of African-Americans with affective disorders.

    PubMed

    Jarvis, G Eric

    2012-12-01

    This article explored the origins and implications of the underdiagnosis of affective disorders in African-Americans. MEDLINE and old collections were searched using relevant key words. Reference lists from the articles that were gathered from this procedure were reviewed. The historical record indicated that the psychiatric perception of African-Americans with affective disorders changed significantly during the last 200 years. In the antebellum period, the mental disorders of slaves mostly went unnoticed. By the early 20th century, African-Americans were reported to have high rates of manic-depressive disorder compared with whites. By the mid-century, rates of manic-depressive disorder in African-Americans plummeted, whereas depression remained virtually nonexistent. In recent decades, diagnosed depression and bipolar disorder, whether in clinical or research settings, were inexplicably low in African-Americans compared with whites. Given these findings, American psychiatry needs to appraise the deep-seated effects of historical stereotypes on the diagnosis and treatment of African-Americans.

  3. Transthyretin Ile 122: Gene frequency and risk of cardiac amyloidosis in African Americans

    SciTech Connect

    Buxbaum, J. |; Pastore, R.; Yaghoubian, R.

    1994-09-01

    Point mutations in the protein transthyretin (TTR) cause familial amyloidosis involving mainly the heart and peripheral nerves. To determine the TTR Ile 122 gene frequency in African Americans, the allele encoding TTR Ile 122 was identified by PCR-Primer Introduced Restriction Analysis of TTR exon 4 and FokI digestion on 1659 control DNA samples from 1659 African Americans: 64 were heterozygous and one homozygous (allele frequency .02). To determine the risk to gene carriers of developing cardiac amyloidosis, immunohistochemical and genetic studies were performed on amyloid-containing samples identified among 52,370 autopsy samples examined over 32 years. In autopsy samples from patients over age 60, isolated cardiac amyloidosis was more common in African Americans (1.6%) than in White Americans (.40%), suggesting a genetic risk factor. All 29 samples from African Americans were immunohistochemically TTR-positive, and 5 were heterozygous for the TTR Ile 122 allele (17%), as compared with 5/108 heterozygotes (4.6%) among age-matched (over age 60) African American controls without amyloidosis from the same autopsy study (one-tailed P value < .03). Among the 29 amyloid-positive samples were 16 with 1+ or 2+ deposition and 13 with 3+ or 4+ deposition. All 5 TTR Ile 122 heterozygotes had 3+ or 4+ deposition. None of 15 samples from White Americans with cardiac amyloidosis was TTR Ile 122-positive. Extrapolating from the 5/29 samples from which we were able to obtain genetic data, we estimate that 9/54 samples containing cardiac amyloid were TTR Ile 122 heterozygotes. We conclude that heterozygosity for TTR Ile 122 is associated with a greater frequency (relative risk 5.8) and greater severity of cardiac amyloid deposition than in non-carriers of the TTR Ile 122 gene. Of over 40 TTR point mutations associated with amyloidosis described to date, TTR Ile 122 appears to be the most common worldwide and to have the lowest penetrance in causing disease.

  4. Preparing African American Counselor Education Students for the Professorate

    ERIC Educational Resources Information Center

    Johnson, Phillip D.; Bradley, Carla R.; Knight, Donald E.; Bradshaw, Elizabeth S.

    2007-01-01

    The purpose of this article is to highlight the underrepresentation of African American faculty in CACREP-Accredited counseling programs and to discuss ways of creating and sustaining a pipeline of potential counselor educators for the academy. (Contains 1 table.)

  5. Risk of injury in African American hospital workers.

    PubMed

    Simpson, C L; Severson, R K

    2000-10-01

    Very few data exist that describe the risk of injury in African American health care workers, who are highly represented in health care occupations. The present study examined the risk for work-related injury in African American hospital workers. Hospital Occupational Health Service medical records and a hospital human resource database were used to compare risk of injury between African American and white workers after adjusting for gender, age, physical demand of the job, and total hours worked. Risk of work-related injury was 2.3 times higher in African Americans. This difference was not explained by the other independent variables. Differences in injury reporting, intra-job workload, psychosocial factors, and organizational factors are all potential explanations for racial disparity in occupational injury. More research is needed to clarify these findings. PMID:11039167

  6. Assessing Stigma among African Americans Living with HIV

    PubMed Central

    Rao, Deepa; Molina, Yamile; Lambert, Nina; Cohn, Susan E.

    2016-01-01

    Purpose In the present study, we validated a culturally adapted stigma scale designed to assess stigma among African Americans living with HIV. Methods We collected data on the scale using an audio computer assisted self-interview (ACASI) format. We validated the scale with a sample of 62 African American participants living with HIV. Results Findings demonstrated that stigma can be measured succinctly and effectively in a 14-item scale with two subscales measuring enacted and internalized stigma. Discussion We identified many advantages to using the scale, which demonstrated good psychometric properties when used with an audio computer assisted self-interview format and with an African American sample. We recommend this scale’s use in both clinical practice and research study of HIV-stigma reduction interventions with African American populations. PMID:27761520

  7. African Americans and HIV/AIDS: cultural concerns.

    PubMed

    Jordan, Wilbert C; Vaughn, Anita C; Hood, Rodney G

    2004-10-01

    AIDS is a disease that has had a disproportionate effect on African Americans. While there has been significant progress in the treatment of people with HIV infection, there are obstacles to the optimal treatment of African Americans, such as distrust of the medical system, cultural differences between patients and providers, and institutional racism. To optimize treatment of African Americans with HIV/AIDS, health care providers must learn more about cultural issues that impact treatment. The goals of treatment for African Americans with HIV infection are the same as those for all patients: maintain durable suppression of HIV replication, prevent resistance, support optimal immune system function, extend AIDS-free survival time, maximize adherence to antiretroviral regimens, and improve quality of life.

  8. Increasing the adjustment success of the disabled African American.

    PubMed

    Miller, S D

    1993-01-01

    Adjustment to a physically disabling condition is a challenge for any patient who confronts a future of severe impairment and limited mobility. The emotional trauma is usually devastating at least until the initial shock of the disability dissipates. For the disabled African-American patient, the physical and psychic pain are compounded by personal and social factors not experienced in similar intensity by other disabled patients. A conceptual framework for better understanding the nature of the forces that impinge on the ability of the disabled African-American patient to adjust and an understanding of the impact of multi-level systems on the life of the disabled African-American is provided. The influence of racism, be it intentional or unintentional, is explained as it relates to the services and the attitudes of health care systems. The family as a significant and vital system is discussed as the major contributor to the successful adjustment of African-American disabled persons.

  9. KSC kicks off African-American History Month

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Mack McKinney, chief, program resources management at NASA and chairperson for African-American History Month, presents a plaque to Bhetty Waldron at the kick-off ceremony of African-American History Month on Feb. 3 at the NASA Training Auditorium. The award was given in thanks for Waldron's portrayal of Dr. Mary McLeod Bethune and Zora Neal Hurston during the ceremony. The theme for this year's observation is 'Heritage and Horizons: The African-American Legacy and the Challenges of the 21st Century.' February is designated each year as a time to celebrate the achievements and contributions of African Americans to Kennedy Space Center, NASA and the nation.

  10. Directory of Scholarships for African-American Students.

    ERIC Educational Resources Information Center

    Journal of Blacks in Higher Education, 1994

    1994-01-01

    This database lists scholarships specifically available to African American students and some available to minority students in general. Scholarships for undergraduates in general and specific fields and awards for graduate and professional students are listed. (SLD)

  11. Reaching rural African American women difficult. Researcher discusses chief issues.

    PubMed

    2005-06-01

    Poverty and inequality are among the major challenges faced by the rural African American women at risk for HIV infection, and they increase this population's potential for becoming infected, an expert says.

  12. Barriers to using palliative care: insight into African American culture.

    PubMed

    Drisdom, Sheronda

    2013-08-01

    As the hospice care setting becomes more racially and ethnically diverse, attending to the different conditions and needs of various groups is essential to providing optimal care. African Americans make up only a small percentage of hospice users in the United States. This article highlights barriers associated with the underenrollment of African Americans into hospice and palliative care programs. A thorough analysis of the literature was conducted to define hospice and palliative care and assess circumstances that impact the use of hospice services by African Americans. Many African Americans are not choosing hospice care because of cultural issues or knowledge deficits, whether through lack of communication or low literacy. Healthcare providers can begin by familiarizing themselves with hospice organizations and developing and putting into practice strategies to communicate with and educate patients and families about hospice care in a culturally sensitive manner. PMID:23899976

  13. Telephone Surveys Underestimate Cigarette Smoking among African-Americans

    PubMed Central

    Landrine, Hope; Corral, Irma; Simms, Denise Adams; Roesch, Scott C.; Pichon, Latrice C.; Ake, Diane; Villodas, Feion

    2013-01-01

    Background: This study tested the hypothesis that data from random digit-dial telephone surveys underestimate the prevalence of cigarette smoking among African-American adults. Method: A novel, community-sampling method was used to obtain a statewide, random sample of N = 2118 California (CA) African-American/Black adults, surveyed door-to-door. This Black community sample was compared to the Blacks in the CA Health Interview Survey (N = 2315), a statewide, random digit-dial telephone survey conducted simultaneously. Results: Smoking prevalence was significantly higher among community (33%) than among telephone survey (19%) Blacks, even after controlling for sample differences in demographics. Conclusion: Telephone surveys underestimate smoking among African-Americans and probably underestimate other health risk behaviors as well. Alternative methods are needed to obtain accurate data on African-American health behaviors and on the magnitude of racial disparities in them. PMID:24350205

  14. Mandombian Perspective: Constitutive Matrix For African-American Scientists.

    ERIC Educational Resources Information Center

    De Lancey, Frenzella Elaine

    1995-01-01

    Contends that the analysis of a Nigerian chieftain can offer crucial understanding of contemporary African-American scientists. Uses theoretical frame, methodology, and interpretive strategies of Afrocentric theory. Contains 24 references. (DDR)

  15. Transgenerational Consequences of Racial Discrimination for African American Health

    PubMed Central

    Goosby, Bridget J.; Heidbrink, Chelsea

    2014-01-01

    Disparities in African American health remain pervasive and persist transgenerationally. There is a growing consensus that both structural and interpersonal racial discrimination are key mechanisms affecting African American health. The Biopsychosocial Model of Racism as a Stressor posits that the persistent stress of experiencing discrimination take a physical toll on the health of African Americans and is ultimately manifested in the onset of illness. However, the degree to which the health consequences of racism and discrimination can be passed down from one generation to the next is an important avenue of exploration. In this review, we discuss and link literature across disciplines demonstrating the harmful impact of racism on African American physical health and the health of their offspring. PMID:24855488

  16. Transgenerational Consequences of Racial Discrimination for African American Health.

    PubMed

    Goosby, Bridget J; Heidbrink, Chelsea

    2013-08-01

    Disparities in African American health remain pervasive and persist transgenerationally. There is a growing consensus that both structural and interpersonal racial discrimination are key mechanisms affecting African American health. The Biopsychosocial Model of Racism as a Stressor posits that the persistent stress of experiencing discrimination take a physical toll on the health of African Americans and is ultimately manifested in the onset of illness. However, the degree to which the health consequences of racism and discrimination can be passed down from one generation to the next is an important avenue of exploration. In this review, we discuss and link literature across disciplines demonstrating the harmful impact of racism on African American physical health and the health of their offspring.

  17. Factors influencing medical information seeking among African American cancer patients.

    PubMed

    Matthews, Alicia K; Sellergren, Sarah A; Manfredi, Clara; Williams, Maryann

    2002-01-01

    Qualitative research methods were used to explore factors that may affect medical information seeking, treatment engagement, and emotional adjustment among African American cancer patients. Focus group findings suggest that an array of cultural and socioeconomic factors plays important roles in the behavior of African American cancer patients. Participants described a number of important barriers and facilitators of medical information seeking and treatment participation. Factors linked to the health care-related behaviors and adjustment of African American cancer patients included limited knowledge and misinformation about cancer, mistrust of the medical community, concerns about privacy, lack of insurance, religious beliefs, and emotional issues such as fear and stigma associated with seeking emotional support. Recommendations are made that may assist mental and physical health providers in improving patient information and mental and physical health outcomes of African American cancer patients.

  18. African American and European American Mothers’ Beliefs about Negative Emotions and Emotion Socialization Practices

    PubMed Central

    Nelson, Jackie A.; Leerkes, Esther M.; O’Brien, Marion; Calkins, Susan D.; Marcovitch, Stuart

    2012-01-01

    SYNOPSIS Objective Mothers’ beliefs about their children’s negative emotions and their emotion socialization practices were examined. Design Sixty-five African American and 137 European American mothers of 5-year-old children reported their beliefs and typical responses to children’s negative emotions, and mothers’ emotion teaching practices were observed. Results African American mothers reported that the display of negative emotions was less acceptable than European American mothers, and African American mothers of boys perceived the most negative social consequences for the display of negative emotions. African American mothers reported fewer supportive responses to children’s negative emotions than European Americans and more nonsupportive responses to children’s anger. African American mothers of boys also reported more nonsupportive responses to submissive negative emotions than African American mothers of girls. However, no differences were found by ethnicity or child gender in observed teaching about emotions. Group differences in mothers’ responses to negative emotions were explained, in part, by mothers’ beliefs about emotions. Conclusions Differences in beliefs and practices may reflect African American mothers’ efforts to protect their children from discrimination. PMID:22639552

  19. Fine-mapping and initial characterization of QT interval loci in African Americans.

    PubMed

    Avery, Christy L; Sethupathy, Praveen; Buyske, Steven; He, Qianchuan; Lin, Dan-Yu; Arking, Dan E; Carty, Cara L; Duggan, David; Fesinmeyer, Megan D; Hindorff, Lucia A; Jeff, Janina M; Klein, Liviu; Patton, Kristen K; Peters, Ulrike; Shohet, Ralph V; Sotoodehnia, Nona; Young, Alicia M; Kooperberg, Charles; Haiman, Christopher A; Mohlke, Karen L; Whitsel, Eric A; North, Kari E

    2012-01-01

    The QT interval (QT) is heritable and its prolongation is a risk factor for ventricular tachyarrhythmias and sudden death. Most genetic studies of QT have examined European ancestral populations; however, the increased genetic diversity in African Americans provides opportunities to narrow association signals and identify population-specific variants. We therefore evaluated 6,670 SNPs spanning eleven previously identified QT loci in 8,644 African American participants from two Population Architecture using Genomics and Epidemiology (PAGE) studies: the Atherosclerosis Risk in Communities study and Women's Health Initiative Clinical Trial. Of the fifteen known independent QT variants at the eleven previously identified loci, six were significantly associated with QT in African American populations (P≤1.20×10(-4)): ATP1B1, PLN1, KCNQ1, NDRG4, and two NOS1AP independent signals. We also identified three population-specific signals significantly associated with QT in African Americans (P≤1.37×10(-5)): one at NOS1AP and two at ATP1B1. Linkage disequilibrium (LD) patterns in African Americans assisted in narrowing the region likely to contain the functional variants for several loci. For example, African American LD patterns showed that 0 SNPs were in LD with NOS1AP signal rs12143842, compared with European LD patterns that indicated 87 SNPs, which spanned 114.2 Kb, were in LD with rs12143842. Finally, bioinformatic-based characterization of the nine African American signals pointed to functional candidates located exclusively within non-coding regions, including predicted binding sites for transcription factors such as TBX5, which has been implicated in cardiac structure and conductance. In this detailed evaluation of QT loci, we identified several African Americans SNPs that better define the association with QT and successfully narrowed intervals surrounding established loci. These results demonstrate that the same loci influence variation in QT across multiple

  20. Lack of Association of the APOL1 G3 Haplotype in African Americans with ESRD

    PubMed Central

    Ng, Maggie C.Y.; Langefeld, Carl D.; Divers, Jasmin; Lea, Janice P.; Okusa, Mark D.; Kimberly, Robert P.; Bowden, Donald W.

    2015-01-01

    Apolipoprotein L1 gene (APOL1) G1 and G2 variants are strongly associated with progressive nondiabetic nephropathy in populations with recent African ancestry. Selection for these variants occurred as a result of protection from human African trypanosomiasis (HAT). Resequencing of this region in 10 genetically and geographically distinct African populations residing in HAT endemic regions identified eight single nucleotide polymorphisms (SNPs) in strong linkage disequilibrium and comprising a novel G3 haplotype. To determine whether the APOL1 G3 haplotype was associated with nephropathy, G1, G2, and G3 SNPs and 70 ancestry informative markers spanning the genome were genotyped in 937 African Americans with nondiabetic ESRD, 965 African Americans with type 2 diabetes–associated ESRD, and 1029 non-nephropathy controls. In analyses adjusting for age, sex, APOL1 G1/G2 risk (recessive), and global African ancestry, the G3 haplotype was not significantly associated with ESRD (P=0.05 for nondiabetic ESRD, P=0.57 for diabetes-associated ESRD, and P=0.27 for all-cause ESRD). We conclude that variation in APOL1 G3 makes a nominal, if any, contribution to ESRD in African Americans; G1 and G2 variants explain the vast majority of nondiabetic nephropathy susceptibility. PMID:25249559

  1. Lack of Association of the APOL1 G3 Haplotype in African Americans with ESRD.

    PubMed

    Palmer, Nicholette D; Ng, Maggie C Y; Langefeld, Carl D; Divers, Jasmin; Lea, Janice P; Okusa, Mark D; Kimberly, Robert P; Bowden, Donald W; Freedman, Barry I

    2015-05-01

    Apolipoprotein L1 gene (APOL1) G1 and G2 variants are strongly associated with progressive nondiabetic nephropathy in populations with recent African ancestry. Selection for these variants occurred as a result of protection from human African trypanosomiasis (HAT). Resequencing of this region in 10 genetically and geographically distinct African populations residing in HAT endemic regions identified eight single nucleotide polymorphisms (SNPs) in strong linkage disequilibrium and comprising a novel G3 haplotype. To determine whether the APOL1 G3 haplotype was associated with nephropathy, G1, G2, and G3 SNPs and 70 ancestry informative markers spanning the genome were genotyped in 937 African Americans with nondiabetic ESRD, 965 African Americans with type 2 diabetes-associated ESRD, and 1029 non-nephropathy controls. In analyses adjusting for age, sex, APOL1 G1/G2 risk (recessive), and global African ancestry, the G3 haplotype was not significantly associated with ESRD (P=0.05 for nondiabetic ESRD, P=0.57 for diabetes-associated ESRD, and P=0.27 for all-cause ESRD). We conclude that variation in APOL1 G3 makes a nominal, if any, contribution to ESRD in African Americans; G1 and G2 variants explain the vast majority of nondiabetic nephropathy susceptibility.

  2. Use and Misuse of Speech Diagnostics for African American Students

    ERIC Educational Resources Information Center

    Baugh, John

    2015-01-01

    Many African American students have been tested using speech pathology diagnostics that are ill suited to their distinctive linguistic circumstances. Slave descendants of African origin share a unique linguistic heritage in contrast and comparison to every other immigrant group residing within America. In an effort to overcome the legacy of…

  3. Title I: African-American Studies Program. Student Workbook.

    ERIC Educational Resources Information Center

    Wilson, Linda

    This is a student workbook in African American studies used in the Detroit, Michigan public schools in 1978-79. The workbook contains student exercises in African history, culture, geography, languages, architecture, folktales, food, and artifacts. The continent of Africa is covered in units on Egypt, North Africa, West Africa, Central Africa, and…

  4. In Our Own Image: An African American History.

    ERIC Educational Resources Information Center

    Rochester City School District, NY.

    This textbook for elementary school children is a history of African Americans from 800 A.D. to 1992 in 24 chapters. Each chapter closes with a review that lists vocabulary words to learn, and offers thinking and writing questions. Some chapters also contain activity sheets. Chapter topics include African origins, black explorers and settlers in…

  5. Sweet Words So Brave: The Story of African American Literature.

    ERIC Educational Resources Information Center

    Brodie, James Michael; Curry, Barbara K.

    This illustrated book introduces readers to African American literature by telling the story of the men and women who contributed to this body of work. The book begins by recounting the Africans' journey into slavery and how they kept their stories alive by telling them to one another, and by handing them down from generation to generation.…

  6. Outcomes in African Americans and Hispanics with lupus nephritis.

    PubMed

    Contreras, G; Lenz, O; Pardo, V; Borja, E; Cely, C; Iqbal, K; Nahar, N; de La Cuesta, C; Hurtado, A; Fornoni, A; Beltran-Garcia, L; Asif, A; Young, L; Diego, J; Zachariah, M; Smith-Norwood, B

    2006-05-01

    Poor outcomes have been reported in African Americans and Hispanics compared to Caucasians with lupus nephritis. The purpose of this retrospective analysis was to identify independent predictors of outcomes in African Americans and Hispanics with lupus nephritis. In total, 93 African Americans, 100 Hispanics, and 20 Caucasians with a mean age of 28 +/- 13 years and an annual household income of 32.9 +/- 17.3 (in 1000 US dollars) were studied. World Health Organization (WHO) lupus nephritis classes II, III, IV, and V were seen in 9, 13, 52, and 26%, respectively. Important baseline differences were higher mean arterial pressure (MAP) in African Americans compared to Hispanics and Caucasians (107 +/- 19, 102 +/- 15, and 99 +/- 13 mmHg, P < 0.05), and higher serum creatinine (1.66 +/- 1.3, 1.25 +/- 1.0, and 1.31 +/- 1.0 mg/dl, P < 0.025). African Americans had lower hematocrit compared to Hispanics and Caucasians (29 +/- 5, and 31 +/- 6, and 32 +/- 7%, P < 0.05), and lower annual household income (30.8 +/- 14.9, 33.1 +/- 15.9, and 42.2 +/- 29.3 in 1000 US dollars; P < 0.05). Lower prevalence of WHO class IV was seen in Caucasians (30%) compared to Hispanics (57%, P = 0.03) and African Americans (51%, P = 0.09). Development of doubling creatinine or end-stage renal disease was higher in African Americans and Hispanics than in Caucasians (31, 18, and 10%; P < 0.05), as was the development of renal events or death (34, 20, and 10%; P < 0.025). Our results suggest that both biological factors indicating an aggressive disease and low household income are common in African Americans and Hispanics with lupus nephritis, and outcomes in these groups are worse than in Caucasians.

  7. Marital Satisfaction among African Americans and Black Caribbeans: Findings from the National Survey of American Life

    ERIC Educational Resources Information Center

    Bryant, Chalandra M.; Taylor, Robert Joseph; Lincoln, Karen D.; Chatters, Linda M.; Jackson, James S.

    2008-01-01

    This study examines the correlates of marital satisfaction using data from a national probability sample of African Americans (N = 962) and Black Caribbeans (N = 560). Findings reveal differences between African Americans and Black Caribbeans, and men and women within those groups, in the predictors of marital satisfaction. Black Caribbean women…

  8. A Comparison of Depressive Symptoms in African Americans and Caucasian Americans.

    ERIC Educational Resources Information Center

    Ayalon, Liat; Young, Michael A.

    2003-01-01

    Examined group differences in depressive symptomatology among African Americans and whites seeking psychotherapy. African Americans reported less pessimism, dissatisfaction, self-blame, and suicidal ideation and more sense of punishment and weight change, but for reasons unrelated to depression. Self-dislike was a stronger manifestation of…

  9. Cultural In-Group Advantage: Emotion Recognition in African American and European American Faces and Voices

    ERIC Educational Resources Information Center

    Wickline, Virginia B.; Bailey, Wendy; Nowicki, Stephen

    2009-01-01

    The authors explored whether there were in-group advantages in emotion recognition of faces and voices by culture or geographic region. Participants were 72 African American students (33 men, 39 women), 102 European American students (30 men, 72 women), 30 African international students (16 men, 14 women), and 30 European international students…

  10. An Empirical Examination of Inter-Ethnic Stereotypes: Comparing Asian American and African American Employees.

    ERIC Educational Resources Information Center

    Gilbert, Jackie; Carr-Ruffino, Norma; Ivancevich, John M.; Lownes-Jackson, Millicent

    2003-01-01

    Undergraduates (n=127) read career histories (including photographs) of fictitious employees in a 2x2x2 design depicting job type (engineer/human resources), ethnicity (Asian or African American), and gender, with the same qualifications and performance information. African-American males were rated most negatively on work characteristics;…

  11. Intentions to Donate to a Biobank in a National Sample of African Americans

    PubMed Central

    McDonald, Jasmine A.; Vadaparampil, Susan; Bowen, Deborah; Magwood, Gayenell; Obeid, Jihad S.; Jefferson, Melanie; Drake, Richard; Gebregziabher, Mulugeta; Halbert, Chanita Hughes

    2015-01-01

    Background/Aims Despite the investments being made to develop biobanks, African Americans are under-represented in genomic studies. We identified factors having significant independent associations with intentions to donate personal health information and blood and/or tissue samples to a biobank in a national, random sample of African Americans (n=1,033). Methods National survey conducted from October 2010 through February 2011. Results 23% of respondents reported that it was not at all likely that they would donate to a biobank, 18% reported a little likely, 36% reported somewhat likely, and 23% reported very likely. Respondents who were likely to donate to a biobank had greater positive expectations about participating in cancer genetics research and reported more participation facilitators relative to barriers. Respondents who were distrustful of researchers had a significantly lower likelihood of being willing to donate to a biobank compared to those who were less distrustful. Conclusions African Americans have diverse attitudes about participating in genetics research and many are likely to donate to a biobank based on expectations of positive outcomes. It may be important to address attitudes about genetics research as part of recruitment to enhance the quality of informed consent for participation in biobanks among African Americans. PMID:24942180

  12. Advancing breast cancer survivorship among African-American women.

    PubMed

    Coughlin, Steven S; Yoo, Wonsuk; Whitehead, Mary S; Smith, Selina A

    2015-09-01

    Advances have occurred in breast cancer survivorship but, for many African-American women, challenges and gaps in relevant information remain. This article identifies opportunities to address disparities in breast cancer survival and quality of life, and thereby to increase breast cancer survivorship among African-American women. For breast cancer survivors, common side effects, lasting for long periods after cancer treatment, include fatigue, loss of strength, difficulty sleeping, and sexual dysfunction. For addressing physical and mental health concerns, a variety of interventions have been evaluated, including exercise and weight training, dietary interventions, yoga and mindfulness-based stress reduction, and support groups or group therapy. Obesity has been associated with breast cancer recurrence and poorer survival. Relative to white survivors, African-American breast cancer survivors are more likely to be obese and less likely to engage in physical activity, although exercise improves overall quality of life and cancer-related fatigue. Considerable information exists about the effectiveness of such interventions for alleviating distress and improving quality of life among breast cancer survivors, but few studies have focused specifically on African-American women with a breast cancer diagnosis. Studies have identified a number of personal factors that are associated with resilience, increased quality of life, and positive adaptation to a breast cancer diagnosis. There is a need for a better understanding of breast cancer survivorship among African-American women. Additional evaluations of interventions for improving the quality of life and survival of African-American breast cancer survivors are desirable. PMID:26303657

  13. African Americans in bereavement: grief as a function of ethnicity.

    PubMed

    Laurie, Anna; Neimeyer, Robert A

    2008-01-01

    Few empirical studies have explored the grieving process among different ethnic groups within the United States, and very little is known about how African Americans and Caucasians may differ in their experience of loss. The purpose of this study was to examine the African-American experience of grief, with particular emphasis on issues of identity change, interpersonal dimensions of the loss, and continuing attachments with the deceased. Participants were 1,581 bereaved college students (940 Caucasians and 641 African Americans) attending classes at a large southern university. Each participant completed the Inventory of Complicated Grief-Revised, the Continuing Bonds Scale, and questions regarding the circumstances surrounding his or her loss. Results revealed that African Americans experienced more frequent bereavement by homicide, maintenance of a stronger continuing bond with the deceased, greater grief for the loss of extended kin beyond the immediate family, and a sense of support in their grief, despite their tendency to talk less with others about the loss or seek professional support for it. Overall, African Americans reported higher levels of complicated grief symptoms than Caucasians, especially when they spent less time speaking to others about their loss experience. Implications of these findings for bereavement support services for African Americans were briefly noted.

  14. African American leadership groups: smoking with the enemy

    PubMed Central

    Yerger, V; Malone, R

    2002-01-01

    Background: Among all racial and ethnic groups in the USA, African Americans bear the greatest burden from tobacco related disease. The tobacco industry has been highly influential in the African American community for decades, providing funding and other resources to community leaders and emphasising publicly its support for civil rights causes and groups, while ignoring the negative health effects of its products on those it claims to support. However, the industry's private business reasons for providing such support were unknown. Objective: To understand how and for what purposes the tobacco industry sought to establish and maintain relationships with African American leaders. Methods: Review and analysis of over 700 previously secret internal tobacco industry documents available on the internet. Results: The tobacco industry established relationships with virtually every African American leadership organisation and built longstanding social connections with the community, for three specific business reasons: to increase African American tobacco use, to use African Americans as a frontline force to defend industry policy positions, and to defuse tobacco control efforts. Conclusion: As the tobacco industry expands its global reach, public health advocates should anticipate similar industry efforts to exploit the vulnerabilities of marginalised groups. The apparent generosity, inclusion, and friendship proffered by the industry extract a price from groups in the health of their members. Helping groups anticipate such efforts, confront industry co-optation, and understand the hidden costs of accepting tobacco industry largesse should be part of worldwide tobacco control efforts. PMID:12432159

  15. Bessie Coleman, First African American Pilot

    NASA Technical Reports Server (NTRS)

    1921-01-01

    Born on January 26, 1892 in Atlanta, Texas to a family of sharecroppers, Bessie Coleman grew up in poverty. Her father abandoned the family when she was nine, and her elder brothers soon left as well, leaving her mother with the four youngest of her thirteen children. While taking care of her younger sisters, Bessie completed all eight available years of primary education, excelling in math. She enrolled at the Colored Agricultural and Normal University in Langston, Oklahoma in 1910, but lack of funds forced her to leave after only one term. Five years later, she left the South and moved to Chicago to join two of her brothers, Walter and John, where she worked as a beautician for several years. An avid reader, she learned about World War I pilots in the newspaper and became intrigued by the prospect of flying. As a black woman, she had no chance of acceptance at any American pilot school, so she moved to France in 1919 and enrolled at the Ecole d'Aviation des Freres Caudon at Le Crotoy. After returning briefly to the United States, she spent one more term in France practicing more advanced flying before finally settling back in her birth country. She did exhibition flying and gave lectures across the country from 1922 to 1926. While flying, she refused to perform unless the audiences were desegregated. She was test flying a new plane on April 30, 1926 when it malfunctioned, killing both her and the mechanic who was piloting it. Her career as the world's first African American pilot inspired many who followed.

  16. Obesity and Pulmonary Function in African Americans

    PubMed Central

    Mehari, Alem; Afreen, Samina; Ngwa, Julius; Setse, Rosanna; Thomas, Alicia N.; Poddar, Vishal; Davis, Wayne; Polk, Octavius D.; Hassan, Sheik; Thomas, Alvin V.

    2015-01-01

    Background Obesity prevalence in United States (US) adults exceeds 30% with highest prevalence being among blacks. Obesity is known to have significant effects on respiratory function and obese patients commonly report respiratory complaints requiring pulmonary function tests (PFTs). However, there is no large study showing the relationship between body mass index (BMI) and PFTs in healthy African Americans (AA). Objective To determine the effect of BMI on PFTs in AA patients who did not have evidence of underlying diseases of the respiratory system. Methods We reviewed PFTs of 339 individuals sent for lung function testing who had normal spirometry and lung diffusion capacity for carbon monoxide (DLCO) with wide range of BMI. Results Functional residual capacity (FRC) and expiratory reserve volume (ERV) decreased exponentially with increasing BMI, such that morbid obesity resulted in patients breathing near their residual volume (RV). However, the effects on the extremes of lung volumes, at total lung capacity (TLC) and residual volume (RV) were modest. There was a significant linear inverse relationship between BMI and DLCO, but the group means values remained within the normal ranges even for morbidly obese patients. Conclusions We showed that BMI has significant effects on lung function in AA adults and the greatest effects were on FRC and ERV, which occurred at BMI values < 30 kg/m2. These physiological effects of weight gain should be considered when interpreting PFTs and their effects on respiratory symptoms even in the absence of disease and may also exaggerate existing lung diseases. PMID:26488406

  17. Illness beliefs in African Americans with hypertension.

    PubMed

    Pickett, Stephanie; Allen, Wilfred; Franklin, Mary; Peters, Rosalind M

    2014-02-01

    Guided by Leventhal's common sense model of illness representations, this study examined the relationship between hypertension beliefs and self-care behaviors necessary for blood pressure (BP) control in a sample of 111 community-dwelling African Americans with hypertension. Participants completed the revised Illness Perception Questionnaire, BP Self-Care Scale, and a demographic data sheet, and had BP measured. Analyses revealed that beliefs about the causes of hypertension differed by gender and educational level. Stress-related causal attributions accounted for 34.7% of the variance in hypertension beliefs. Participants who believed stress or external factors caused hypertension were less likely to engage in healthy self-care behaviors (e.g., keeping doctor visits, eating low-salt, low-fat diets). Results suggest that patients who are nonadherent with hypertension self-care recommendations may hold hypertension beliefs that are not consistent with the medically endorsed views of this disease. To more effectively treat and control BP, providers should assess patients' hypertension beliefs.

  18. Racism and cardiovascular disease in African Americans.

    PubMed

    Wyatt, Sharon B; Williams, David R; Calvin, Rosie; Henderson, Frances C; Walker, Evelyn R; Winters, Karen

    2003-06-01

    This article provides an overview of the evidence on the ways racism can affect the disproportionate rates of cardiovascular disease (CVD) in African Americans. It describes the significant health disparities in CVD for blacks and whites and suggests that racial disparities should be understood within the context of persistent inequities in societal institutions and relations. Evidence and potential pathways for exploring effects of 3 levels of racism on cardiovascular health risk factors and outcomes are reviewed. First, institutional racism can lead to limited opportunities for socioeconomic mobility, differential access to goods and resources, and poor living conditions that can adversely affect cardiovascular health. Second, perceived/personally mediated racism acts as a stressor and can induce psychophysiological reactions that negatively affect cardiovascular health. Third, in race-conscious societies, such as the United States, the negative self-evaluations of accepting negative cultural stereotypes as true (internalized racism) can have deleterious effects on cardiovascular health. Few population-based studies have examined the relationship between racism and CVD. The findings, though suggestive of a positive association, are neither consistent nor clear. The research agenda of the Jackson Heart Study in addressing the role of racism in CVD is presented.

  19. An Investigation of African American Parents' Perception of School Leaders as It Relates to Parent Engagement and the African American Male Student

    ERIC Educational Resources Information Center

    Currie, Delvon Denise

    2013-01-01

    The purpose of this study was to investigate African American parents' perception of school leaders as it relates to parent engagement and the African American male student. Specifically, this study addressed African American parents' perceptions of the quality of their child's education and the quality of communication they received from their…

  20. The Influence of the African American Father on Level of Self-Efficacy, Career Achievement, and Aspirations of His African American Daughter

    ERIC Educational Resources Information Center

    Stewart, April E.

    2014-01-01

    The purpose of this correlational study was to investigate the influence of perceived and desired paternal involvement of the African American father on his African American daughter. The research problem is how father involvement may influence self-efficacy, career achievements, and aspirations of African American females. This study sought to…

  1. Consequences of learning about historical racism among European American and African American children.

    PubMed

    Hughes, Julie M; Bigler, Rebecca S; Levy, Sheri R

    2007-01-01

    Knowledge about racism is a critical component of educational curricula and contemporary race relations. To examine children's responses to learning about racism, European American (Study 1; N= 48) and African American (Study 2; N= 69) elementary-aged children (ages 6-11) received history lessons that included information about racism experienced by African Americans (racism condition), or otherwise identical lessons that omitted this information (control condition). Children's racial attitudes and cognitive and affective responses to the lessons were assessed. Among European American children, racism condition participants showed less biased attitudes toward African Americans than control condition participants. Among African American children, attitudes did not vary by condition. Children in the two conditions showed several different cognitive and affective responses to the lessons.

  2. Providing Culturally Relevant Mental Health Services: Collaboration between Psychology and the African American Church.

    ERIC Educational Resources Information Center

    Queener, John E.; Martin, Juanita K.

    2001-01-01

    Presents a model of collaboration between psychologists and the African American church, discussing the connection between African psychology and religion, examining barriers to and strategies for collaboration between psychologists and the African American church, and describing the collaborative model called the African American Counseling Team.…

  3. Crossing Cultures in Marriage: Implications for Counseling African American/African Couples

    ERIC Educational Resources Information Center

    Durodoye, Beth A.; Coker, Angela D.

    2008-01-01

    A wealth of literature exists regarding intermarriage between White and ethnic minority couples. Noticeably lacking, however, is information considering within-group diversity amongst Black couples. This paper will focus on cultural dynamics that may operate with African American and African couples residing in the United States. Through an…

  4. The Long Path to Higher Education for African Americans

    ERIC Educational Resources Information Center

    Duster, Troy

    2009-01-01

    When one considers the possibilities for a new progressive era in American higher education, the author contends that it is wise to review the past because there are lessons to be learned. In fact, the latter part of the 20th century was one of great progress for diversity in higher education, generally speaking, and for African Americans in…

  5. Key Competencies: African and Afro-American Studies, Secondary Education.

    ERIC Educational Resources Information Center

    Philadelphia School District, PA. Office of Curriculum and Instruction.

    This booklet identifies major competencies for African and Afro-American studies courses in grades seven through 12 in the Philadelphia school system. Afro-American studies are viewed as (1) developing students' ability to gain insights and destroy stereotypes and (2) providing a frame of reference for understanding the forces which have shaped…

  6. Factors Affecting African American Counselors' Job Satisfaction: A National Survey

    ERIC Educational Resources Information Center

    Jones, Cravor; Hohensil, Thomas H.; Burge, Penny

    2009-01-01

    Although there are many job satisfaction studies, research related to the job satisfaction of African American counselors (AACs) is negligible. The purpose of this study was to investigate the job satisfaction of AACs. A total of 182 employed AACs who were members of the American Counseling Association (ACA) completed a modified Minnesota…

  7. Hispanic versus African American Girls: Body Image, Nutrition, and Puberty

    ERIC Educational Resources Information Center

    Talpade, Medha

    2008-01-01

    Public health research has been dominated by the biomedical model, which does not appear to be appropriate for studying public health variables across different populations. For example, when comparing the Hispanic American (HA) and African American (AA) population in the U.S., there are similarities on several demographic and public health…

  8. Welfare Systems and African-Americans: Historical Notes

    ERIC Educational Resources Information Center

    Nicholson, Rosetta

    1975-01-01

    An historical discussion of the relationship of American welfare systems to African-Americans, stating that Europeans, primarily from England, reluctantly established meagre, inhumane welfare systems based on seventeenth century English philosophy and tradition for members of their own nationality group after more than two centuries of poverty in…

  9. Vital Signs: The State of African Americans in Higher Education.

    ERIC Educational Resources Information Center

    Cross, Theodore L.; And Others

    1994-01-01

    Presents a statistical record of the progress of African Americans in institutions of higher education in the United States. Statistics include trends in black enrollment, library resources in historically black colleges, leading foundation grants, blacks in business schools, and comparative analysis of Asian Americans and blacks in higher…

  10. The Secrets of My Success: An African American Librarian.

    ERIC Educational Resources Information Center

    Kemp, Roberta

    1994-01-01

    Relates the experiences of an African-American woman who won an ALA (American Library Association) scholarship to attend library school. Topics discussed include leadership programs; changing careers; finances; ALA conference experiences; ALA's Black Caucus; and working part-time while attending school part-time. (LRW)

  11. Cultural Enrichment: Connecting African American Elementary Children to Academic Achievement

    ERIC Educational Resources Information Center

    Winston, Deborah L.

    2011-01-01

    A large, growing number of mis-educated American citizens are being produced by America's public schools. Many of these students are being funneled into the penal system shortly after dropping out of high school. This phenomenon is especially prevalent among African American male students, many of whom have withdrawn academically years prior…

  12. Marriage, Money, and African American Mothers' Self-Esteem

    ERIC Educational Resources Information Center

    Mandara, Jelani; Johnston, Jamie S.; Murray, Carolyn B.; Varner, Fatima

    2008-01-01

    This study examined the effects of marital status and family income on the self-esteem of 292 African American mothers. Counter to previous studies with European American mothers, family income moderated the effects of marital status. Those mothers with higher family income had higher self-esteem, regardless of their marital status. For those with…

  13. The Amistad Research Center: Documenting the African American Experience.

    ERIC Educational Resources Information Center

    Chepesiuk, Ron

    1993-01-01

    Describes the Amistad Research Center housed at Tulane University which is a repository of primary documents on African-American history. Topics addressed include the development and growth of the collection; inclusion of the American Missionary Association archives; sources of support; civil rights; and collecting for the future. (LRW)

  14. Domestic Transracial Adoption: In the Words of African American Adoptees

    ERIC Educational Resources Information Center

    Smith, Ellen M.

    2013-01-01

    Domestic transracial adoption has sparked more controversy than any other type of adoption. For the purposes of this study domestic transracial adoption is defined as European American parents adopting African American children. Many of the studies completed are contradictory and fail to control for variables that affect the outcome such as age of…

  15. Cultural Dysthymia: An Unrecognized Disorder among African Americans?

    ERIC Educational Resources Information Center

    Vontress, Clemmont E.; Woodland, Calvin E.; Epp, Lawrence

    2007-01-01

    Many African Americans experience low-grade depression, referred to as dysthymia in the Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev.; American Psychiatric Association, 2000). After more than 250 years of enslavement, prejudice, and discrimination, dysthymia is reflected in chronic low-grade sadness, anger, hostility,…

  16. Exercise economy in African American and European American women.

    PubMed

    Hunter, Gary R; McCarthy, John P; Bamman, Marcas M; Larson-Meyer, D Enette; Fisher, Gordon; Newcomer, Bradley R

    2011-08-01

    We have previously shown that Achilles tendon length is related to walking economy on the flat, presumably because of increased stretch-shortening cycle elastic energy savings. In addition, greater walking economy in African American (AA) women compared to European American (EA) women is explained by longer Achilles tendons in AA women. The purposes of this study were to determine whether economy while walking up a grade and during isometric plantar flexion, two tasks expected to produce proportionately less energy savings from elastic savings are different between AA and EA women. We evaluated walking economy at 4.8 km/h at 0 and 2.5% grade in 48 AA and 48 EA premenopausal women. Plantar flexor muscle metabolic economy (force/ATP) was also evaluated using (31) phosphate magnetic resonance spectroscopy ((31)P-MRS). AA women walked on the flat more economically (net VO(2), AA 8.3 and EA 8.9 ml kg(-1) min(-1), P = 0.04). No significant ethnic differences were observed while walking up a 2.5% grade or in (31)P-MRS determined plantar flexor muscle metabolic economy. These data support our previous study's suggestion that AA women are more economical while walking on the flat. On the other hand, in activities in which stretch-shortening cycle elastic energy savings would be expected to be reduced (grade walking and isometric force production), no differences in economy during grade walking or isometric force production were observed suggesting that biomechanical, i.e. stretch-shortening cycle elastic energy savings differences rather biochemical differences contribute to the better flat walking economy observed in AA women.

  17. Exercise economy in African American and European American women

    PubMed Central

    McCarthy, John P.; Bamman, Marcas M.; Larson-Meyer, D. Enette; Fisher, Gordon; Newcomer, Bradley R.

    2011-01-01

    We have previously shown that Achilles tendon length is related to walking economy on the flat, presumably because of increased stretch–shortening cycle elastic energy savings. In addition, greater walking economy in African American (AA) women compared to European American (EA) women is explained by longer Achilles tendons in AA women. The purposes of this study were to determine whether economy while walking up a grade and during isometric plantar flexion, two tasks expected to produce proportionately less energy savings from elastic savings are different between AA and EA women. We evaluated walking economy at 4.8 km/h at 0 and 2.5% grade in 48 AA and 48 EA premenopausal women. Plantar flexor muscle metabolic economy (force/ATP) was also evaluated using 31 phosphate magnetic resonance spectroscopy (31P-MRS). AA women walked on the flat more economically (net VO2, AA 8.3 and EA 8.9 ml kg−1 min−1, P = 0.04). No significant ethnic differences were observed while walking up a 2.5% grade or in 31P-MRS determined plantar flexor muscle metabolic economy. These data support our previous study’s suggestion that AA women are more economical while walking on the flat. On the other hand, in activities in which stretch–shortening cycle elastic energy savings would be expected to be reduced (grade walking and isometric force production), no differences in economy during grade walking or isometric force production were observed suggesting that biomechanical, i.e. stretch–shortening cycle elastic energy savings differences rather biochemical differences contribute to the better flat walking economy observed in AA women. PMID:21229260

  18. HIV/AIDS in African Americans. National Minority AIDS Council.

    PubMed

    1998-06-01

    The National Minority AIDS Council (NMAC) answered the call of the Congressional Black Caucus by asking President Clinton to declare a state of emergency on HIV and AIDS among African-Americans. The Centers for Disease Control and Prevention (CDC) estimates that of the seven Americans infected with HIV every hour, three are African-Americans. NMAC is calling on Federal, State, and local government leaders to implement widespread public information and education campaigns that target African-Americans, and that address voluntary HIV testing, dispel the shame and stigma associated with HIV/AIDS, discuss the needs of gay African-American men, address the accessibility of appropriate resources for HIV treatment, coordinate the expansion of drug prevention and treatment programs, implement a national needle exchange policy, and allocate funds for researching HIV treatment in minority populations. Dr. Beny Primm, vice-chair of NMAC, states that efforts to fight HIV/AIDS must be integrated with other obstacles affecting the African-American community.

  19. Nursing's role in racism and African American women's health.

    PubMed

    Eliason, M J

    1999-01-01

    African American women's health has been neglected in the nursing and other health care literature, in spite of evidence that they are among the most vulnerable populations in the United States today. In this article, I highlight the health disparities between African American and European American women, discuss possible reasons for the disparities, and propose that nursing as a profession has been complicit in perpetuating the racism of health care and society. Although the focus is on nursing research and practice, it is likely that other health care disciplines perpetuate racism in similar ways.

  20. Culturally sensitive oral health educational materials for older African Americans.

    PubMed

    Slaughter, Ann; Evans, Lois K

    2007-11-01

    Oral diseases disproportionately affect older Americans from minority populations. Approaches to reducing such disparities include increasing community-based interventions that target vulnerable older adults. To help in developing and implementing such programs, the U.S. Department of Health and Human Services suggests using the MAP-IT technique, from a strategic planning guide to address public health issues in the community. This approach served as the method of investigation for the Take Charge of Your Oral Health educational program, a health promotion initiative targeting older African Americans. This paper describes the development and evaluation of the program. A total of 111 African American elders from 7 senior sites in Philadelphia participated in the program. A 6-item pre-test and post-test indicated a significant improvement in mean test scores from baseline (p,.001). The program demonstrated merit in improving oral health knowledge among community-residing, inner city, older African Americans.

  1. A small number of candidate gene SNPs reveal continental ancestry in African Americans.

    PubMed

    Kodaman, Nuri; Aldrich, Melinda C; Smith, Jeffrey R; Signorello, Lisa B; Bradley, Kevin; Breyer, Joan; Cohen, Sarah S; Long, Jirong; Cai, Qiuyin; Giles, Justin; Bush, William S; Blot, William J; Matthews, Charles E; Williams, Scott M

    2013-01-01

    Using genetic data from an obesity candidate gene study of self-reported African Americans and European Americans, we investigated the number of Ancestry Informative Markers (AIMs) and candidate gene SNPs necessary to infer continental ancestry. Proportions of African and European ancestry were assessed with STRUCTURE (K = 2), using 276 AIMs. These reference values were compared to estimates derived using 120, 60, 30, and 15 SNP subsets randomly chosen from the 276 AIMs and from 1144 SNPs in 44 candidate genes. All subsets generated estimates of ancestry consistent with the reference estimates, with mean correlations greater than 0.99 for all subsets of AIMs, and mean correlations of 0.99 ± 0.003; 0.98 ± 0.01; 0.93 ± 0.03; and 0.81 ± 0.11 for subsets of 120, 60, 30, and 15 candidate gene SNPs, respectively. Among African Americans, the median absolute difference from reference African ancestry values ranged from 0.01 to 0.03 for the four AIMs subsets and from 0.03 to 0.09 for the four candidate gene SNP subsets. Furthermore, YRI/CEU Fst values provided a metric to predict the performance of candidate gene SNPs. Our results demonstrate that a small number of SNPs randomly selected from candidate genes can be used to estimate admixture proportions in African Americans reliably.

  2. The Ball Curve: Calculated Racism and the Stereotype of African American Men.

    ERIC Educational Resources Information Center

    Hall, Ronald E.

    2001-01-01

    Discusses the impact of racial stereotyping on the performance of African American and European American athletes, providing an alternative to race-based intelligence differentials. Focuses on stereotypes of African American men; the Bell Curve; the high proportion of African Americans in U.S. athletics; and masculinity and the stereotype of the…

  3. Feature Articles on African Americans in Sports Illustrated in the 1990s

    ERIC Educational Resources Information Center

    Angela Lumpkin

    2009-01-01

    This descriptive study examined whether the coverage of African Americans in the feature articles in Sports Illustrated during the 1990s was representative of their participation levels. Nearly half of the articles featured European Americans; about one-third featured African Americans. More African Americans were featured in basketball, boxing,…

  4. Assessment of the Status of African-Americans. Volume V: Health and Medical Care of African-Americans.

    ERIC Educational Resources Information Center

    Reed, Wornie L.; Darity, William, Sr.; Roman, Stanford; Baquet, Claudia; Roberson, Norma L.

    In 1987 a project was undertaken to assess the status of African Americans in the United States in the topical areas to be addressed by the National Research Council's Study Committee on the Status of Black Americans: education, employment, income and occupations, political participation and the administration of justice, social and cultural…

  5. School and Peer Influences on the Academic Outcomes of African American Adolescents

    PubMed Central

    Estrada-Martinez, Lorena; Colin, Rosa J.; Jones, Brittni D.

    2015-01-01

    Little scholarship explores how adolescents’ beliefs about school and peers influence the academic outcomes of African American boys and girls. The sample included 612 African American boys (N=307, Mage=16.84) and girls (N=305, Mage=16.79). Latent class analysis (LCA) revealed unique patterns for African American boys and girls. Findings indicate that for African American boys, school attachment was protective, despite having peers who endorsed negative achievement values. Furthermore, socio-economic (SES) status was associated with higher grade point averages (GPA) for African American girls. Overall, these findings underscore the unique role of school, peer, and gendered experiences in lives of African American adolescents. PMID:26277404

  6. A prospective study of serum 25-hydroxyvitamin d levels and mortality among African Americans and non-African Americans.

    PubMed

    Signorello, Lisa B; Han, Xijing; Cai, Qiuyin; Cohen, Sarah S; Cope, Elizabeth L; Zheng, Wei; Blot, William J

    2013-01-15

    The beneficial biologic effects attributed to vitamin D suggest a potential to influence overall mortality. Evidence addressing this hypothesis is limited, especially for African Americans who have a high prevalence of vitamin D insufficiency. The authors conducted a nested case-control study within the prospective Southern Community Cohort Study to relate baseline serum levels of 25-hydroxyvitamin D (25(OH)D) with subsequent mortality. Cases were 1,852 participants who enrolled from 2002 to 2009 and died >12 months postenrollment. Controls (n = 1,852) were matched on race, sex, age, enrollment site, and blood collection date. The odds ratios for quartile 1 (<10.18 ng/mL) versus quartile 4 (>21.64 ng/mL) levels of 25(OH)D were 1.60 (95% confidence interval (CI): 1.20, 2.14) for African Americans and 2.11 (95% CI: 1.39, 3.21) for non-African Americans. The effects were strongest for circulatory disease death, where quartile 1 versus quartile 4 odds ratios were 2.53 (95% CI: 1.44, 4.46) and 3.25 (95% CI: 1.33, 7.93) for African Americans and non-African Americans, respectively. The estimated odds of total mortality were minimized in the 25(OH)D range of 35-40 ng/mL. These findings provide support for the hypothesis that vitamin D status may have an important influence on mortality for both African Americans and non-African Americans.

  7. Cultural Variations in Parenting: Perceptions of Caucasian, African-American, Hispanic, and Asian-American Parents.

    ERIC Educational Resources Information Center

    Julian, Teresa W.; And Others

    1994-01-01

    Examined cultural variations in parenting attitudes, behavior, and involvement of mothers and fathers in two-parent families. Findings from Caucasian (n=2,642), African-American (n=469), Hispanic-American (n=357), and Asian-American (n=49) parents revealed that, as group, ethnic parents indicated greater general emphasis on children exerting…

  8. Perceptions of Support Among Older African American Cancer Survivors

    PubMed Central

    Hamilton, Jill B.; Moore, Charles E.; Powe, Barbara D.; Agarwal, Mansi; Martin, Pamela

    2010-01-01

    Purpose/Objectives To explore the perceived social support needs among older adult African American cancer survivors. Research Approach Qualitative design using grounded theory techniques. Setting Outpatient oncology clinics in the southeastern United States. Participants Focus groups with 22 older adult African American cancer survivors. Methodologic Approach Purposeful sampling technique was used to identify focus group participants. In-depth interviews were conducted and participants were interviewed until informational redundancy was achieved. Main Research Variables Social support needs of older adult African American patients with cancer. Findings Social support was influenced by (a) symptoms and treatment side effects, (b) perceptions of stigma and fears expressed by family and friends, (c) cultural beliefs about cancer, and (d) desires to lessen any burden or disruption to the lives of family and friends. Survivors navigated within and outside of their networks to get their social support needs met. In some instances, survivors socially withdrew from traditional sources of support for fear of being ostracized. Survivors also described feeling hurt, alone, and socially isolated when completely abandoned by friends. Conclusions The support from family, friends, and fellow church members is important to positive outcomes among older African American cancer survivors. However, misconceptions, fears, and negative cultural beliefs persist within the African American community and negatively influence the social support available to this population. Interpretations Early identification of the factors that influence social support can facilitate strategies to improve outcomes and decrease health disparities among this population. PMID:20591808

  9. African-American youth: essential prevention strategies for every pediatrician.

    PubMed

    Murray-Garcia, J

    1995-07-01

    National statistics of morbidity and mortality warrant our urgent attention to the issue of effective prevention strategies among African-Americans. Implicit, explicit, and often internalized messages of inferior value, negative expectations, and expendability remain a part of everyday life for African-American youth. This sociopolitical disenfranchisement has a direct impact on their health and development and on our ability to provide effective preventive and therapeutic intervention. Pediatricians enjoy a deserved perception of expertise in those areas that bear directly on the healthy physical and psychosocial development of all children. We have not heretofore optimally exploited this perceived and real expertise in prevention efforts among African-American children. We ourselves are in need of reeducation. We need to first shatter the insidious conceptual barriers of our own impotence as well as the perceived impotence of African-American patients in our collective abilities to inspire and affect change. On a patient-by-patient basis, among our regional pediatric communities and in the public policy arena, we can be involved in the process that restores to our African-American patients a sense of full citizenship and potential within our society. Without adoption of this process of sociopolitical reenfranchisement, our best-intended efforts at prevention in this community will always tragically fall short of their full and critically needed potential.

  10. The Diabetic Health of African American Grandmothers Raising their Grandchildren

    PubMed Central

    Carthron, Dana L.; Busam, Maria Rivera

    2016-01-01

    PURPOSE The purpose of this study is to compare the health of primary caregiving African American grandmothers with diabetes with African American women with diabetes who were not primary caregivers. DESIGN Using a comparative, descriptive, cross-sectional design, 34 African American primary caregiving grandmothers were compared with 34 non-caregiving women with diabetes mellitus; women aged 55–75 years were recruited for this study throughout the central Arkansas. METHODS To measure the overall health, data on blood pressure, body mass index measurements, HbA1c levels, total cholesterol, and urine protein and creatinine levels were collected from all the participants. RESULTS Statistically significant differences between the caregivers and non-caregivers groups in systolic pressure (t = −3.42, P = 0.001) and diastolic pressure (t = −3.790, P = 0.000) and urine protein (W = 294.00, P = 0.000) were noted. Additionally, a clinically significant difference in HbA1c was noted between groups. CONCLUSION Differences in systolic and diastolic pressures, urine protein, and clinically significant differences in HbA1c suggest that African American primary caregiving grandmothers with diabetes mellitus may have more difficulty in maintaining their diabetic health than non-caregiving African American women. PMID:27398044

  11. Unheard Voices: African American Fathers Speak about their Parenting Practices

    PubMed Central

    Doyle, Otima; Clark, Trenette T.; Cryer-Coupet, Qiana; Nebbitt, Von E.; Goldston, David B.; Estroff, Sue E.; Magan, Ifrah

    2015-01-01

    Researchers have called for qualitative investigations into African American fathers’ parenting practices that consider their social context and identify specific practices. Such investigations can inform the way we conceptualize African American fathers’ parenting practices, which can in turn contribute to prevention interventions with at-risk youth. We conducted semi-structured, qualitative interviews about parenting with 30 self-identified, African American, biological fathers of pre-adolescent sons at-risk for developing aggressive behaviors, depressive symptoms, or both. Fathers provided descriptions of their parenting practices, which were at times influenced by their environmental context, fathers’ residential status, and masculine ideologies. Our systematic analysis revealed four related themes that emerged from the data: managing emotions, encouragement, discipline, and monitoring. Of particular note, fathers in the current sample emphasized the importance of teaching their sons to manage difficult emotions, largely utilized language consistent with male ideologies (i.e., encouragement rather than love or nurturance), and engaged in high levels of monitoring and discipline in response to perceived environmental challenges and the developmental needs of their sons. The findings provide deeper insight into the parenting practices of African American fathers who are largely understudied, and often misunderstood. Further, these findings highlight considerations that may have important implications for father-focused prevention interventions that support African American fathers, youth, and families. PMID:26366126

  12. Assessment of religious and spiritual capital in African American communities.

    PubMed

    Holt, Cheryl L; Schulz, Emily; Williams, Beverly; Clark, Eddie M; Wang, Min Qi; Southward, Penny L

    2012-12-01

    African American faith communities are an important source of social capital. The present study adapted a theory-based social capital instrument to result in religious (e.g., from organized worship) and spiritual (e.g., from relationship with higher power) capital measures. Data from a national sample of 803 African Americans suggest the instruments have high internal reliability and are distinct from general religiosity. Measurement models confirmed factor structures. Religious capital was positively associated with self-rated health status. Religious and spiritual capital were negatively associated with depressive symptoms, but these associations largely became nonsignificant in multivariate models that controlled for demographic characteristics. An exception is for spiritual capital in the form of community participation, which retained a negative association with depressive symptoms. These instruments may have applied value for health promotion research and practice in African American communities.

  13. Culturally Conscientious Pain Measurement in Older African Americans.

    PubMed

    Booker, Staja Q; Herr, Keela A; Tripp-Reimer, Toni

    2016-10-01

    Despite considerable pain disparities across the care continuum, pain is an understudied health problem in older ethnic minority groups, such as African Americans. Quality pain measurement is a core task in pain management and a mechanism by which pain disparities may be reduced. Pain measurement includes the methods (e.g., assessment approaches, tools) and metrics that researchers and clinicians use to understand the characteristics of pain. However, there are significant issues and gaps that negatively affect pain measurement in older African Americans. Of concern is insufficient representation in pain research, which impedes the testing and refinement of many standardized self-report, behavioral and surrogate report, physiological, and composite measures of pain. The purposes for this article are to discuss the status of pain measurement and factors that affect our knowledge on pain measurement in older African Americans, and to provide guidance for culturally conscientious pain measurement using the available literature. PMID:27174228

  14. Culturally Conscientious Pain Measurement in Older African Americans.

    PubMed

    Booker, Staja Q; Herr, Keela A; Tripp-Reimer, Toni

    2016-10-01

    Despite considerable pain disparities across the care continuum, pain is an understudied health problem in older ethnic minority groups, such as African Americans. Quality pain measurement is a core task in pain management and a mechanism by which pain disparities may be reduced. Pain measurement includes the methods (e.g., assessment approaches, tools) and metrics that researchers and clinicians use to understand the characteristics of pain. However, there are significant issues and gaps that negatively affect pain measurement in older African Americans. Of concern is insufficient representation in pain research, which impedes the testing and refinement of many standardized self-report, behavioral and surrogate report, physiological, and composite measures of pain. The purposes for this article are to discuss the status of pain measurement and factors that affect our knowledge on pain measurement in older African Americans, and to provide guidance for culturally conscientious pain measurement using the available literature.

  15. Fatalistic Beliefs about Cancer Prevention among Older African American Men

    PubMed Central

    Manning, Mark; Shires, Deirdre; Chapman, Robert A.; Burnett, Janice

    2014-01-01

    Objectives Evidence suggests that minority groups are more likely to exhibit fatalistic beliefs about cancer prevention (FBCP); defined as confusion, pessimism, and helplessness about one’s ability to prevent cancer. This study examines socioeconomic and psychosocial predictors of FBCP among older African American men. Methods African American men (N=1,666) enrolled in Medicare and participating in a longitudinal study on patient navigation were surveyed. Measures included three FBCP constructs, demographic items, and physical and mental health variables. Binary logistic regression was performed. Results The average participant was 73.6 years old; 76.5% felt helpless, 44.2% were confused, and 40.7% were pessimistic about the ability to prevent cancer. As education increased, so did all three FBCP. Being downhearted was predictive of confused and helpless beliefs. Discussion It is critical for health practitioners to understand how psychosocial and economic challenges influence beliefs that may impede cancer prevention efforts for older African American men. PMID:25651585

  16. HIV/AIDS stigma and religiosity among African American women.

    PubMed

    Muturi, Nancy; An, Soontae

    2010-06-01

    African American women are disproportionately affected by HIV/AIDS compared with other ethnicities, accounting for two-thirds (67%) of all women diagnosed with HIV. Despite their increased risk of HIV infection, few studies have been conducted to understand culture-specific factors leading to their vulnerability. Given the central role of religious organizations in African American communities, this study explored whether and to what extent religiosity plays a role in stigma toward HIV/AIDS. Results of hierarchical regression showed that after controlling for key factors, religiosity was a significant factor predicting the level of religious stigma. Those with high religiosity displayed significantly higher stigma, associating HIV/AIDS with a curse or punishment from God. Verbatim responses to an open-ended question also revealed seemingly ingrained prejudice against HIV/AIDS from a religious perspective. The findings point to the important role of faith-based organizations (FBOs) in addressing HIV/AIDS issues within African American communities.

  17. The African-American cancer crisis, Part II: A prescription.

    PubMed

    Byrd, W M; Clayton, L A

    1993-01-01

    To appreciate the causes of the African-American cancer crisis, contemporary myths and perceptual gaps regarding cancer in blacks must be analyzed and placed in historical context. Since ancient times, racism has permeated western scientific, medical, and social cultures. Yet contemporary analysts typically frame a 370-year-old African-American health deficit in nonracial terms, and ignore both the metamorphosis of racism and the impact of racism on the prevention, diagnosis, and treatment of cancer; exposure to cancer-causing industrial pollutants; educational opportunities for black health professionals and policymakers, and other factors. If the African-American cancer crisis is to be halted, the growing divergence between urgent needs and meager resources devoted to preventing, detecting, and treating cancer in blacks must be sharply reversed.

  18. Health and nutritional status of old-old African Americans.

    PubMed

    Bernard, M A; Anderson, C; Forgey, M

    1995-01-01

    This study reports the initial results of a baseline cross-sectional evaluation of the health and nutritional status of 58 old-old African Americans, 74 years of age and older, residing in low income housing complexes in metropolitan Oklahoma City. Although the population had a high overall functional status, cognitive status, and mood, there were a number of nutritional parameters suggestive of nutritional risk. In particular, 20% of subjects had relatively low serum albumin levels, 14% had serum cholesterol levels below 160 mg/dl, and a subset of the population reported low intake during 24 hour dietary recall. The National Center and Caucus on Black Aged report that 60% of African American elders live at or below the poverty level. These study findings suggest that the present cohort of African American elders may be at nutritional risk.

  19. African-American Women's Perceptions and Experiences About Breastfeeding.

    PubMed

    Obeng, Cecilia S; Emetu, Roberta E; Curtis, Terry J

    2015-01-01

    There are health benefits to breastfeeding for both mothers and their children. The preventive health effects of breastfeeding continue into adulthood, lowering rate of various chronic illnesses. African-American women, especially of lower socioeconomic status, are less likely to breastfeed in comparison to their racial and ethnic counterparts. The purpose of this study is to explore how African-American women experience breastfeeding in the early stages of postpartum care. Two focus groups (N = 20, 10 in each group) were conducted with African-American mothers. Results revealed that participants felt that there were health benefits to breastfeeding, and organizations such as Women, Infants, and Children (WIC) provided support. However, participants stated that lack of information, negative perceptions, and unforeseen circumstances were barriers to breastfeeding. This study proposes support and interventions for this group to increase breastfeeding among this population. PMID:26734597

  20. Incarceration, African Americans, and HIV: Advancing a Research Agenda

    PubMed Central

    Harawa, Nina; Adimora, Adaora

    2010-01-01

    Incarceration is a crisis among African-Americans, and the prevalence of HIV/AIDS in incarcerated men and women is three to five times that of the general population. We explore the potential implications of the widespread incarceration of African Americans on HIV risk and HIV outcomes in 1) the current and formerly incarcerated, 2) their sexual partners, and 3) the communities impacted by incarceration. We set forth a research agenda for understanding and ameliorating the negative impacts incarceration and conclude that African-American populations’ ability to successfully address the HIV/AIDS epidemic requires a coordinated and evidence-based response to the challenge of effectively preventing, managing, and treating HIV in populations affected by incarceration. PMID:18277809

  1. African American women's breast memories, cancer beliefs, and screening behaviors.

    PubMed

    Thomas, Eileen C

    2004-01-01

    African American women experience higher breast cancer mortality and lower survival rates compared with white women of comparable age and cancer stage. The literature is lacking in studies that address the influence of past events on current health behaviors among women of diverse cultural groups. This qualitative exploratory study used participant narratives to examine associations between women's memories and feelings concerning their breasts and current breast cancer screening behaviors. Twelve professional African American women, aged 42 to 64 years, shared stories about memories and feelings regarding their breasts. Codes grouped together with related patterns and recurrences revealed categories that encompassed the language and culture of the participants. The categories identified were Seasons of Breast Awareness, Womanhood, Self-Portraits, Breast Cancer and Cancer Beliefs, Breast Cancer Screening Experiences, and Participants' Advice for Change. These categories provide direction for further exploration of barriers to health promotion practices among African American women and women in general.

  2. Breast cancer incidence and mortality in a Caribbean population: comparisons with African-Americans.

    PubMed

    Hennis, Anselm J; Hambleton, Ian R; Wu, Suh-Yuh; Leske, Maria Cristina; Nemesure, Barbara

    2009-01-15

    We describe breast cancer incidence and mortality in the predominantly African-origin population of Barbados, which shares an ancestral origin with African-Americans. Age-standardized incidence rates were calculated from histologically confirmed breast cancer cases identified during a 45-month period (July 2002-March 2006). Mortality rates were estimated from death registrations over 10-years starting January 1995. There were 396 incident cases of breast cancer for an incidence rate of 78.1 (95% confidence interval (CI) 70.5-86.3), standardized to the US population. Breast cancer incidence in African-Americans between 2000 and 2004 was 143.7 (142.0-145.5) per 100,000. Incidence peaked at 226.6 (174.5-289.4) per 100,000 among Barbadian women aged 50-54 years, and declined thereafter, a pattern in marked contrast to trends in African-American women, whose rates continued to increase to a peak of 483.5 per 100,000 in those aged 75-79 years. Incidence rate ratios comparing Barbadian and African-American women showed no statistically significant differences among women aged>or=55 years (pAfrican-American women may suggest a greater contribution from genetic factors in younger women, and from environmental factors in older women. Studies in intermediate risk populations, such as Barbados, may assist the understanding of racial disparities in breast cancer.

  3. Psychocultural Correlates of Mental Health Service Utilization Among African American and European American Girls

    PubMed Central

    Hipwell, Alison E.; Stepp, Stephanie D.; Keenan, Kate

    2015-01-01

    Structural equation modeling was used to examine the effects of cultural factors (ethnic identity, perceived discrimination), family relations, and child problem type on mental health service utilization in a community sample of 1,480 adolescent girls (860 African American, 620 European American) between ages 15 and 17 years enrolled in the Pittsburgh Girls Study. Results revealed ethnic identity, caregiver attachment, and conduct disorder were related to service use among African American girls. Among European American girls, correlate patterns differed by clinical need. Findings highlight the need for research on health disparities to examine racially specific influences on service utilization. PMID:25380787

  4. Characterizing and explaining differences in cognitive test performance between African American and European American older adults

    PubMed Central

    Morgan, Adrienne T. Aiken; Marsiske, Michael; Whitfield, Keith E.

    2007-01-01

    The present study examined differences in cognitive performance of African American and European American older adults on cognitive and intellectual measures, and the extent to which literacy status or reading level was useful in explaining these group differences. African American elders performed more poorly than European American elders on twelve of thirteen cognitive tests administered, p < .05. After controlling for reading level achievement, differences in performance became non-significant for five of these twelve tests. Nonetheless, some differences persisted, suggesting that other potential mediators of race differences remain to be explored in future research. PMID:18189169

  5. African American Smokers’ Intention to Use Pharmacotherapy for Cessation

    PubMed Central

    Lynam, Ian; Catley, Delwyn; Harris, Kari Jo; Goggin, Kathy; Berkley-Patton, Jannette; Thomas, Janet

    2012-01-01

    Objectives To use the theory of planned behavior to identify predictors of intentions to use cessation aids when quitting smoking. Methods African American smokers completed a survey to assess intentions, attitudes, and normative and control beliefs regarding the use of smoking cessation aids. Results Participants held mildly positive attitudes regarding the use of cessation aids. Beliefs related to the utility of aids, support of referents, and accessibility of a doctor were most strongly associated with intention to use cessation aids. Conclusions African American smokers may be amenable to the use of cessation aids, and specific beliefs may be targets for intervention. PMID:22584089

  6. African American families' expectations and intentions for mental health services.

    PubMed

    Thompson, Richard; Dancy, Barbara L; Wiley, Tisha R A; Najdowski, Cynthia J; Perry, Sylvia P; Wallis, Jason; Mekawi, Yara; Knafl, Kathleen A

    2013-09-01

    A cross-sectional qualitative descriptive design was used to examine the links among expectations about, experiences with, and intentions toward mental health services. Individual face-to-face interviews were conducted with a purposive sample of 32 African American youth/mothers dyads. Content analysis revealed that positive expectations were linked to positive experiences and intentions, that negative expectations were not consistently linked to negative experiences or intentions, nor were ambivalent expectations linked to ambivalent experiences or intentions. Youth were concerned about privacy breeches and mothers about the harmfulness of psychotropic medication. Addressing these concerns may promote African Americans' engagement in mental health services.

  7. Barriers to breastfeeding among African American adolescent mothers.

    PubMed

    Brownell, Kim; Hutton, Laurencia; Hartman, Jacqueline; Dabrow, Sharon

    2002-01-01

    The purpose of this study was to define the barriers to breastfeeding in the inner city African American adolescent mother. The study was conducted at Johnnie Ruth Clarke Health Center in St. Petersburg, Florida from October 1999 to February 2000. The study population included 25 African American adolescent mothers between the ages of 15 and 21 years. The results indicate that these mothers possess adequate knowledge about the benefits of breast milk. The greatest barriers to breastfeeding included pain, embarrassment, and lack of interest. These concerns are appropriate given their developmental stage; however, interventions are necessary to address these issues.

  8. Understanding African American's religious beliefs and organ donation intentions.

    PubMed

    Robinson, Dana H Z; Klammer, Susan M Gerbensky; Perryman, Jennie P; Thompson, Nancy J; Arriola, Kimberly R Jacob

    2014-12-01

    African Americans are overrepresented on the organ transplant waiting list and underrepresented among organ and tissue donors. One of the most highly noted reasons for lack of donation is the perception that donation is contrary to religious beliefs. The purpose of this cross-sectional study is to explore the complexities of religion (beliefs, religiosity, and religious involvement) and its association with willingness to donate and the written expression of donation intentions. Findings from a sample of 505 African American participants suggest that religion is a multidimensional construct and results differ depending on how the construct is measured and operationalized.

  9. The genetics of East African populations: a Nilo-Saharan component in the African genetic landscape.

    PubMed

    Dobon, Begoña; Hassan, Hisham Y; Laayouni, Hafid; Luisi, Pierre; Ricaño-Ponce, Isis; Zhernakova, Alexandra; Wijmenga, Cisca; Tahir, Hanan; Comas, David; Netea, Mihai G; Bertranpetit, Jaume

    2015-01-01

    East Africa is a strategic region to study human genetic diversity due to the presence of ethnically, linguistically, and geographically diverse populations. Here, we provide new insight into the genetic history of populations living in the Sudanese region of East Africa by analysing nine ethnic groups belonging to three African linguistic families: Niger-Kordofanian, Nilo-Saharan and Afro-Asiatic. A total of 500 individuals were genotyped for 200,000 single-nucleotide polymorphisms. Principal component analysis, clustering analysis using ADMIXTURE, FST statistics, and the three-population test were used to investigate the underlying genetic structure and ancestry of the different ethno-linguistic groups. Our analyses revealed a genetic component for Sudanese Nilo-Saharan speaking groups (Darfurians and part of Nuba populations) related to Nilotes of South Sudan, but not to other Sudanese populations or other sub-Saharan populations. Populations inhabiting the North of the region showed close genetic affinities with North Africa, with a component that could be remnant of North Africans before the migrations of Arabs from Arabia. In addition, we found very low genetic distances between populations in genes important for anti-malarial and anti-bacterial host defence, suggesting similar selective pressures on these genes and stressing the importance of considering functional pathways to understand the evolutionary history of populations.

  10. The genetics of East African populations: a Nilo-Saharan component in the African genetic landscape

    PubMed Central

    Dobon, Begoña; Hassan, Hisham Y.; Laayouni, Hafid; Luisi, Pierre; Ricaño-Ponce, Isis; Zhernakova, Alexandra; Wijmenga, Cisca; Tahir, Hanan; Comas, David; Netea, Mihai G.; Bertranpetit, Jaume

    2015-01-01

    East Africa is a strategic region to study human genetic diversity due to the presence of ethnically, linguistically, and geographically diverse populations. Here, we provide new insight into the genetic history of populations living in the Sudanese region of East Africa by analysing nine ethnic groups belonging to three African linguistic families: Niger-Kordofanian, Nilo-Saharan and Afro-Asiatic. A total of 500 individuals were genotyped for 200,000 single-nucleotide polymorphisms. Principal component analysis, clustering analysis using ADMIXTURE, FST statistics, and the three-population test were used to investigate the underlying genetic structure and ancestry of the different ethno-linguistic groups. Our analyses revealed a genetic component for Sudanese Nilo-Saharan speaking groups (Darfurians and part of Nuba populations) related to Nilotes of South Sudan, but not to other Sudanese populations or other sub-Saharan populations. Populations inhabiting the North of the region showed close genetic affinities with North Africa, with a component that could be remnant of North Africans before the migrations of Arabs from Arabia. In addition, we found very low genetic distances between populations in genes important for anti-malarial and anti-bacterial host defence, suggesting similar selective pressures on these genes and stressing the importance of considering functional pathways to understand the evolutionary history of populations. PMID:26017457

  11. Human Behavioral Genetics, Scarr's Theory, and Her Views on Interventions: A Critical Review and Commentary on Their Implications for African American Children.

    ERIC Educational Resources Information Center

    Jackson, Jacquelyne Faye

    1993-01-01

    Key components of human behavioral genetics and Sandra Scarr's work of the past two decades are critically reviewed based on scholarship in animal neuropsychology and clinical and educational psychology. Scarr's opinion that interventions to enhance intellectual development are ineffectual for children from abuse- and neglect-free backgrounds is…

  12. Equality for all? White Americans' willingness to address inequality with Asian and African Americans.

    PubMed

    Bikmen, Nida; Durkin, Kristine

    2014-10-01

    White Americans' willingness to engage in dialogues about intergroup commonalities and power inequalities with Asian and African Americans were examined in two experiments. Because Whites perceive that African Americans experience greater discrimination than do Asian Americans, we predicted that they would be more willing to engage in dialogues that would interrogate injustice and inequality with them. We also explored the role of common in-group identity (as Americans) on willingness for dialogue about inequality. In both studies, Whites were less interested in engaging in power talk with Asian Americans than with African Americans, but the difference in willingness for commonality talk was smaller. Asian Americans were perceived as experiencing lower levels of discrimination (Studies 1 and 2) and identify less with America (Study 2) both of which predicted lower willingness for power talk with them. Common in-group identity manipulations had marginal effects on willingness for power talk with African Americans and no effect on power talk with Asian Americans. Implications for improving social disparities between various groups were discussed.

  13. Equality for all? White Americans' willingness to address inequality with Asian and African Americans.

    PubMed

    Bikmen, Nida; Durkin, Kristine

    2014-10-01

    White Americans' willingness to engage in dialogues about intergroup commonalities and power inequalities with Asian and African Americans were examined in two experiments. Because Whites perceive that African Americans experience greater discrimination than do Asian Americans, we predicted that they would be more willing to engage in dialogues that would interrogate injustice and inequality with them. We also explored the role of common in-group identity (as Americans) on willingness for dialogue about inequality. In both studies, Whites were less interested in engaging in power talk with Asian Americans than with African Americans, but the difference in willingness for commonality talk was smaller. Asian Americans were perceived as experiencing lower levels of discrimination (Studies 1 and 2) and identify less with America (Study 2) both of which predicted lower willingness for power talk with them. Common in-group identity manipulations had marginal effects on willingness for power talk with African Americans and no effect on power talk with Asian Americans. Implications for improving social disparities between various groups were discussed. PMID:24749499

  14. Adverse birth outcomes in African American women: the social context of persistent reproductive disadvantage.

    PubMed

    Dominguez, Tyan Parker

    2011-01-01

    African Americans have the highest rates of infant mortality and adverse birth outcomes of all major racial/ethnic groups in the United States. The long-standing nature of this disparity suggests the need to shift epidemiologic focus from individual-level risk factors to the larger social forces that shape disease risk in populations. In this article, the African American reproductive disadvantage is discussed within the context of American race relations. The review of the literature focuses on racism as a social determinant of race-based disparities in adverse birth outcomes with specific attention to the viability of genetic explanations, the role of socioeconomic factors, the multidimensional nature of racism, and the stress-induced physiologic pathways by which racism may negatively affect pregnancy. Implications for social work research and practice also are discussed.

  15. The Effects of Age at Kindergarten Entry on the Reading Proficiency of African American and European American Students

    ERIC Educational Resources Information Center

    Easton-Brooks, Donald; Brown, Amber

    2010-01-01

    European American students are more likely delayed entrance in kindergarten than African American students. This study examined whether age at kindergarten entry influences the reading proficiency skills of African American and European American students at the start of kindergarten, at the end of first grade, and at the end of third grade. Using…

  16. Participation in Extracurricular Activities in the Middle School Years: Are There Developmental Benefits for African American and European American Youth?

    ERIC Educational Resources Information Center

    Fredricks, Jennifer A.; Eccles, Jacquelynne S.

    2008-01-01

    In this study, we examined the associations between organized activity participation during early adolescence and adjustment in a large and economically diverse sample of African American and European American youth. The sample included 1,047 youth (51% female and 49% male and 67% African American and 33% European American). We used analysis of…

  17. Effects of Ethnically Diverse Photographic Stimuli on Preference and Discourse Tasks in African American and Caucasian American Adults

    ERIC Educational Resources Information Center

    Ramkissoon, Ishara; Dagenais, Paul A.; Evans, Kelli J.; Camp, Travis J.; Ferguson, Neina N.

    2013-01-01

    This study determined whether using photographic stimuli displaying different ethnicity (African American vs. Caucasian American) influenced preference, word count, and number of content units produced by African American or Caucasian American participants. Six photograph pairs depicting common scenes were developed, differing only by model…

  18. Parental Attachment, Self-Esteem, and Antisocial Behaviors among African American, European American, and Mexican American Adolescents.

    ERIC Educational Resources Information Center

    Arbona, Consuelo; Power, Thomas G.

    2003-01-01

    Examines the relation of mother and father attachment to self-esteem and self-reported involvement in antisocial behaviors among African American, European American, and Mexican American high school students. Findings indicated that adolescents from the 3 ethnic/racial groups did not differ greatly in their reported attachment. (Contains 70…

  19. Cognitive Skill, Skill Demands of Jobs, and Earnings among Young European American, African American, and Mexican American Workers.

    ERIC Educational Resources Information Center

    Farkas, George; And Others

    1997-01-01

    Analyses of National Longitudinal Survey data indicate that cognitive skill level affects access to high-skill occupations and earnings. Lower cognitive skill levels for African Americans and U.S.-born Mexican Americans explain a substantial proportion of income differences between these groups and European Americans but not the gender gap in pay…

  20. Normative Developmental Trajectories of Aggressive Behaviors in African American, American Indian, Asian American, Caucasian, and Hispanic Children and Early Adolescents

    ERIC Educational Resources Information Center

    Vazsonyi, Alexander T.; Keiley, Margaret K.

    2007-01-01

    The current 5-year accelerated longitudinal investigation modeled the developmental trajectories of aggressive behaviors in 10,107 predominantly minority (greater than 70%; African American, American Indian, Asian American, and Hispanic) children and early adolescents (Kindergarten through 8th grade, 49% female youth) from lower to lower-middle…

  1. Annotated Selected Bibliography & Index for Teaching African-American Learners: Culturally Responsive Pedagogy Project.

    ERIC Educational Resources Information Center

    Hilliard, Asa G.

    This annotated bibliography and index presents nearly 2,000 references that are substantially unique to African or African American teaching and learning. Designed to support teacher education, the bibliography features references that were chosen if they were culturally relevant, recognized the African or African American experience, and drew…

  2. American Ethnic Literatures. Native American, African American, Chicano/Latino, and Asian American Writers and Their Backgrounds. An Annotated Bibliography. Magill Bibliographies.

    ERIC Educational Resources Information Center

    Peck, David R.

    This volume is a serious effort to provide a guide to the range of creative and scholarly work in the four major American ethnic literatures. The burst in creative energy among Native Americans, African Americans, Hispanic Americans, and Asian Americans has made it difficult for teachers to keep up with the primary literature, let alone the…

  3. Use of isosorbide dinitrate and hydralazine in African-Americans with heart failure 9 years after the African-American Heart Failure Trial.

    PubMed

    Ferdinand, Keith Copelin; Elkayam, Uri; Mancini, Donna; Ofili, Elizabeth; Piña, Ileana; Anand, Inder; Feldman, Arthur Michael; McNamara, Dennis; Leggett, Christopher

    2014-07-01

    The 2013 American College of Cardiology Foundation/American Heart Association guidelines recommend combined isosorbide dinitrate (ISDN) and hydralazine to reduce mortality and morbidity for African-Americans with symptomatic heart failure (HF) and reduced ejection fraction, currently receiving optimal medical therapy (class I, level A). Nitrates can alleviate HF symptoms, but continuous use is limited by tolerance. Hydralazine may mitigate nitrate tolerance, and the ISDN-hydralazine combination in the Vasodilators in Heart Failure Trial (V-HeFT) I improved survival and exercise tolerance in men with dilated cardiomyopathy or HF with reduced ejection fraction, most notably in self-identified black participants. In the subsequent V-HeFT II, survival was greater with enalapril than with ISDN-hydralazine in the overall cohort, but mortality rate was similar in the enalapril and ISDN-hydralazine groups in the self-identified black patients. Consequently, in the African-American Heart Failure Trial (A-HeFT) in self-identified black patients with symptomatic HF, adding a fixed-dose combination ISDN-hydralazine to modern guideline-based care improved outcomes versus placebo, including all-cause mortality, and led to early trial termination. Hypertension underlies HF, especially in African-Americans; the A-HeFT and its substudies demonstrated not only improvements in echocardiographic parameters, morbidity, and mortality but also a decrease in hospitalizations, potentially affecting burgeoning HF health-care costs. Genetic characteristics may, therefore, determine response to ISDN-hydralazine, and the Genetic Risk Assessment in Heart Failure substudy demonstrated important hypothesis-generating pharmacogenetic data.

  4. An assessment of home remedy use by African Americans.

    PubMed Central

    Boyd, E. L.; Taylor, S. D.; Shimp, L. A.; Semler, C. R.

    2000-01-01

    This analysis represents the first national look at family and individual use of home remedies by African Americans. The purpose is to examine home remedy usage by African-American individuals and their families and assess the relationship between sociodemographic characteristics and home remedy usage for African-American families and African-American individuals. Using logistic regression, a secondary analysis of the National Survey on Black Americans (NSBA) data (N = 2107) was conducted to examine factors associated with home remedy use. Multivariate analysis indicated that parent's education, importance of religion, living with a grandparent, and living in a rural area were associated with families' use of home remedies. Age, gender, living with a grandparent, education, and geographic region were associated with individual home remedy use. The results of this research may provide insight to health care practitioners in their challenge of appropriately integrating self-care practices (i.e., home remedy use) and the use of the formal health care system among the patients that utilize both "scientific" and "folk" medical systems. When possible, treatment plans should be adapted to consider patients' demographics, health beliefs, and self-care practices. Health care providers should encourage patient and family involvement and dialogue regarding therapeutic approaches. As more information becomes available, health care practitioners will be better able to ascertain the possible health consequences of concurrent usage of home remedies and prescription drug therapies. PMID:10946530

  5. Size and form of the human temporomandibular joint in African-Americans and Caucasians.

    PubMed

    Magnusson, Cecilia; Magnusson, Tomas

    2012-04-01

    The aim of this study was to examine contemporary human skull material for possible differences between Caucasians and African-Americans in respect to size and form of the temporomandibular condyles. The material consisted of a total of 129 Caucasian skulls (94 males and 35 females) and 76 African-American skulls (40 males and 36 females). Their mean age at death was 46 years for the Caucasians (range: 19-89 years) and 37 years for the African-Americans (range: 18-70 years). The mediolateral and anteroposterior dimensions of the 410 condyles were measured, and the condylar form was estimated using both anterior and superior views. No statistically significant differences could be found between Caucasians and African-Americans for any of the recorded variables. In conclusion, the present results lend no support for the existence of ethnic differences between the two groups examined in respect of temporomandibular joint size and form. It is likely that other factors such as evolution, overall cranial size, dietary differences, and genetic factors, irrespective of ethnicity, can explain the differences found in different skull samples.

  6. Chromosome 22q11.2 deletion syndrome in African-American patients: a diagnostic challenge.

    PubMed

    Veerapandiyan, Aravindhan; Abdul-Rahman, Omar A; Adam, Margaret P; Lyons, Michael J; Manning, Melanie; Coleman, Karlene; Kobrynski, Lisa; Taneja, Deeksha; Schoch, Kelly; Zimmerman, Holly H; Shashi, Vandana

    2011-09-01

    Chromosome 22q11.2 deletion syndrome (22q11DS) is associated with numerous and variable clinical manifestations including conotruncal heart abnormalities, palatal anomalies, hypoparathyroidism, immune deficiency, and cognitive deficits. The clinical suspicion of this syndrome is often heightened by the presence of characteristic facial features. A previous report highlighted the under-diagnosis of this condition in African Americans, thought to be related to a paucity of typical facial features. We ascertained the largest cohort (n = 50) of African-American individuals with 22q11DS reported thus far, across five genetics centers in the United States and report on their facial and other phenotypic features. About 3/4 of our cohort has at least one dysmorphic facial feature. Auricular abnormalities, especially small ears, are the most common dysmorphic facial feature followed by nasal and ocular abnormalities. Skeletal findings are seen in about 2/3 of our cohort, higher than the typical frequency reported in 22q11DS. Cardiac anomalies, developmental delay, and palatal abnormalities are seen at a lower frequency in our cohort. Thus, it is evident that the features traditionally associated with 22q11DS are difficult to recognize in African-American individuals with this syndrome, due to both altered frequencies of major anomalies and a non-classic facial appearance. Therefore, a high index of suspicion is needed to recognize 22q11DS in African-American individuals. PMID:21834039

  7. Perspectives of African Americans on Lung Cancer: A Qualitative Analysis

    PubMed Central

    Waldman, Laura Tesler; Browning, Emily; Gagne, Joshua; Emmons, Karen

    2015-01-01

    Background. Disparities in incidence and mortality for lung cancer in African Americans are well documented; however, the extent to which disparities reflect differences in patient perceptions of tobacco and lung cancer treatment is unclear. The objective of this study was to explore African Americans’ knowledge of lung cancer, perceived risk, interest in smoking cessation, attitudes toward lung cancer treatment, and lung cancer diagnosis and treatment experiences. Patients and Methods. The cohort comprised 32 African-American current and former smokers without a cancer diagnosis who participated in focus groups and 10 African Americans with lung cancer who participated in in-depth interviews. Transcripts were analyzed using a modified grounded theory approach. Results. Participants without a cancer diagnosis were aware of the link between smoking and lung cancer, the common symptoms of the disease, and its poor prognosis. They desired specific, personalized smoking-cessation information. If diagnosed, the majority reported, they would seek medical care. Most believed that insurance and socioeconomic factors were more likely to affect treatment access than racial discrimination. Participants with a cancer diagnosis were also aware of the relationship between smoking and lung cancer. They felt their treatment plans were appropriate and trusted their physicians. Most did not believe that race affected their care. Conclusion. This qualitative study suggests that African-American smokers are aware of the relationship between smoking and lung cancer and are interested in smoking-cessation treatment. These data also indicate that lung cancer disparities are unlikely to be associated with differential willingness to receive care but that African Americans may perceive financial and insurance barriers to lung cancer treatment. PMID:25795634

  8. Their Highest Potential: An African American School Community in the Segregated South.

    ERIC Educational Resources Information Center

    Walker, Vanessa Siddle

    The history of the public schooling of African Americans during legalized segregation has focused almost exclusively on the inferior education that African American students received. In the national memory, African Americans have been victims of Whites who questioned the utility of providing Blacks with anything more than a rudimentary education…

  9. What's So "Powerful" about African American Children's Literature?: Let's Ask the Students.

    ERIC Educational Resources Information Center

    Hefflin, Bena R.

    2003-01-01

    Outlines what educators and academics describe as the "power" of children's literature and multicultural children's literature, which includes African American children's literature. Explores what four African American third-graders have to say about the "power" of six African American children's books. Concludes with the patterns and implications…

  10. 'Rise 'n' Shine: Catholic Education and the African-American Community.

    ERIC Educational Resources Information Center

    Chineworth, Mary Alice, Ed.

    African-Americans have been present in Catholic schools since their beginnings in the United States. The six essays in this book examine Catholic education from the perspective of the African-American Catholic. The essays underscore the continued challenge for continuing Catholic schools in the African-American community. They include: (1) an…

  11. School Programs for African American Males. ERIC CUE Digest No. 72.

    ERIC Educational Resources Information Center

    Ascher, Carol

    New educational programs are attempting to meet the needs of male African American students. The new programs vary widely in approach, scope, content, and targeted age group. However, they all focus on helping African American male youth develop productive behaviors and values by bringing them into contact with African American male adults. The…

  12. Mentoring and Professional Identity Development for African American Female Doctoral Students: An Exploratory Study

    ERIC Educational Resources Information Center

    Curry, Nettavia Doreen

    2011-01-01

    This dissertation examines the impact mentoring relationships, between African American women doctoral students and faculty members, has on the students' professional identity development. Of particular interest is an examination of whether matched mentoring relationships between African American women doctoral students and African American female…

  13. African American Young Adult Smoking Initiation: Identifying Intervention Points and Prevention Opportunities

    ERIC Educational Resources Information Center

    Cheney, Marshall K.; Mansker, Jacqueline

    2014-01-01

    Background: African Americans have one of the lowest smoking rates as teens yet have one of the highest smoking rates as adults. Approximately 40% of African Americans who have ever smoked started smoking between the ages of 18 and 21. Purpose: This study aimed to identify why African American young adults began smoking in young adulthood and what…

  14. The All White World of Children's Books & African American Children's Literature.

    ERIC Educational Resources Information Center

    Osa, Osayimwense, Ed.

    The essays in this collection explore African American children's literature and the view it provides of the African American community. Of particular interest is the relationship between African American folktales and those of subSaharan Africa. The following essays are included: (1) "The All-White World of Children's Books" (Nancy Larrick); (2)…

  15. Positionality of African Americans and a Theoretical Accommodation of It: Rethinking Science Education Research

    ERIC Educational Resources Information Center

    Parsons, Eileen R. Carlton

    2008-01-01

    This essay addresses a call for research involving African Americans to interpret data from the historical, contemporary, and cultural experiences of African Americans. The essay argues for a science education research approach that explicitly considers the positionality of African Americans in the United States. This positionality involves the…

  16. Aspects of the Student Engagement of African American Men in Community College

    ERIC Educational Resources Information Center

    Romney, Paulette B.

    2012-01-01

    High attrition rates of African American college students' is a continuing concern of higher education administrators. This is particularly true of African American men attending community college. African American men consistently experience low levels of scholastic achievement as a result of entering college underprepared, with academic deficits…

  17. Performance of African American Preschool and Kindergarten Students on the Expressive Vocabulary Test

    ERIC Educational Resources Information Center

    Thomas-Tate, Shurita; Washington, Julie; Craig, Holly; Packard, Mary

    2006-01-01

    Purpose: To examine the validity of the Expressive Vocabulary Test (EVT; K. Williams, 1997) for assessing the expressive vocabulary skills of African American students. Method/Results: One hundred sixty-five African American preschool and kindergarten students were administered the EVT. The mean EVT score for these African American students was…

  18. African Americans Majoring in Science at Predominantly White Universities (A Review of the Literature)

    ERIC Educational Resources Information Center

    Green, Andre; Glasson, George

    2009-01-01

    One of the most significant problems facing science education is the under-representation of African Americans in science related fields (Young, 2005). African American constitute a little more than 12% of the United States population. However, as recently as 1999 African Americans only comprised only 3.4% of persons working in science and…

  19. Lifting the Voices of High-Achieving, Middle-Class, African American Students

    ERIC Educational Resources Information Center

    Brown, Stacey Marvetta

    2012-01-01

    The state of African American education is complex. Beginning in the 17th century, African Americans fought for an education that allowed them to read and write. During the 21st century, African Americans value on education extends beyond only reading and writing to using these skills and other skills to maintain strong academic and leadership…

  20. Orienting African American Male Adolescents toward Meaningful Literacy Exchanges with Texts

    ERIC Educational Resources Information Center

    Tatum, Alfred W.

    2014-01-01

    Drawing from a sociohistorical understanding of the roles of texts for African American males and data from a recent survey of teens' meaningful experiences with texts, the author provides a general understanding of the roles of texts among African American males and African American male adolescents' meaningful relationships with texts. These…