Science.gov

Sample records for african development coordination

  1. Astronomy for African development

    NASA Astrophysics Data System (ADS)

    Govender, Kevindran

    2011-06-01

    In recent years there have been a number of efforts across Africa to develop the field of astronomy as well as to reap benefit from astronomy for African people. This presentation will discuss the case of the SALT (Southern African Large Telescope) Collateral Benefits Programme (SCBP) which was set up to ensure societal benefit from astronomy. With African society as the target, the SCBP has embarked on various projects from school level education to public understanding of science to socio-economic development, the latter mainly being felt in the rural communities surrounding the South African Astronomical Observatory (home to SALT). A development plan for ``Astronomy in Africa'' will also be discussed. This plan has been drawn up with input from all over Africa and themed ``Astronomy for Education''. The Africa case stands as a good example for the IYA cornerstone project ``Developing Astronomy Globally'' which focuses on developing regions.

  2. Coordinate Standard Measurement Development

    SciTech Connect

    Hanshaw, R.A.

    2000-02-18

    A Shelton Precision Interferometer Base, which is used for calibration of coordinate standards, was improved through hardware replacement, software geometry error correction, and reduction of vibration effects. Substantial increases in resolution and reliability, as well as reduction in sampling time, were achieved through hardware replacement; vibration effects were reduced substantially through modification of the machine component dampening and software routines; and the majority of the machine's geometry error was corrected through software geometry error correction. Because of these modifications, the uncertainty of coordinate standards calibrated on this device has been reduced dramatically.

  3. Political Implications of the Southern African Development Community Agenda on Educational Development in the Region.

    ERIC Educational Resources Information Center

    Nziramasanga, Caiphas T.

    This paper briefly describes the historical development of the Southern African Development Coordination Conference (SADCC) from its roots in 1980 and examines the work of the Southern African Development Community (SADC) today. The objectives of the SADCC are listed from the 1980 declaration and the achievement of those objectives are assessed.…

  4. Transportation in African Development.

    ERIC Educational Resources Information Center

    Altschul, Robert D.

    1980-01-01

    Examines the structure, role, and needs of Africa's national and intracontinental transportation system. Characteristics of rail, water, road, and air transportation are examined. The conclusion is that high investment in transportation systems is essential to the development process. (Author/KC)

  5. Developing anatomical terms in an African language.

    PubMed

    Madzimbamuto, Farai Daniel

    2012-03-01

    Clinical and technical information imparted in most African languages involves inexact terminology and code switching, so it lacks the explanatory power characterised by the English language. African languages are absent in the tertiary science education environment and forums where African scientists could present scientific material in the medium of African languages. This limits the development of African languages in the scientific domain. There has recently been a trend in several African languages to develop and intellectualise them, especially in the field of medical sciences. The ChiShona language is used to explore the ability of an African language to develop new terminology, to name the vertebral skeleton and describe it scientifically. It uses word compounding to demonstrate terminology development. ChiShona has similarities with several hundred other Bantu languages in East, Central and Southern Africa. Advancing this language can promote similar developments in others, making them more explanatory for the lay public and health professionals. PMID:22380900

  6. 75 FR 2844 - African Development Foundation, Board of Directors Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-19

    ...; ] AFRICAN DEVELOPMENT FOUNDATION African Development Foundation, Board of Directors Meeting Time: Tuesday, January 26, 2010, 8:30 a.m. to 1 p.m. Place: African Development Foundation, Conference Room, 1400...

  7. 75 FR 14418 - African Development Foundation, Board of Directors Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-25

    ...; ] AFRICAN DEVELOPMENT FOUNDATION African Development Foundation, Board of Directors Meeting Time: Tuesday, April 13, 2010, 9:30 a.m. to 1 p.m. Place: African Development Foundation, Conference Room, 1400...

  8. 75 FR 45600 - African Development Foundation, Board of Directors Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-03

    ...; ] AFRICAN DEVELOPMENT FOUNDATION African Development Foundation, Board of Directors Meeting Time: Tuesday, August 17, 2010, 8:30 a.m. to 1 p.m. Place: African Development Foundation, Conference Room, 1400...

  9. Development of Coordination in Time Estimation

    ERIC Educational Resources Information Center

    Kiefer, Adam W.; Wallot, Sebastian; Gresham, Lori J.; Kloos, Heidi; Riley, Michael A.; Shockley, Kevin; Van Orden, Guy

    2014-01-01

    How to best characterize cognitive development? The claim put forward in this article is that development is the improvement of a kind of coordination among a variety of factors. To determine the development of coordination in a cognitive task, children between 4 and 12 years of age and adults participated in a time estimation task: They had to…

  10. African Outreach Workshop 1974.

    ERIC Educational Resources Information Center

    Schmidt, Nancy J.

    This report discusses the 1974 African Outreach Workshop planned and coordinated by the African Studies Program at the University of Illinois at Urbana-Champaign. Its major aim was to assist teachers in developing curriculum units on African using materials available in their local community. A second aim was for the African Studies Program to…

  11. Coordinating chemists for global development

    NASA Astrophysics Data System (ADS)

    2016-06-01

    Chemistry research and education face challenges anywhere in the world, but more so in less developed -- or less stable -- economies. These countries and their more economically fortunate neighbours can all contribute to the development of chemistry and its ability to tackle local and global issues.

  12. Multiplayer Activities That Develop Mathematical Coordination.

    ERIC Educational Resources Information Center

    Bricker, Lauren J.; Tanimoto, Steven L.; Rothenberg, Alex I.; Hutama, Danny C.; Wong, Tina H.

    Four computer applications are presented that encourage students to develop "mathematical coordination"--the ability to manipulate numerical variables in cooperation with other students so as to achieve a definite goal. The programs enable a form of computer-supported cooperative learning (CSCL). This paper describes the rationale and design of…

  13. Some Growth Points in African Child Development Research

    ERIC Educational Resources Information Center

    Serpell, Robert; Marfo, Kofi

    2014-01-01

    We reflect on ways in which research presented in earlier chapters responds to challenges of generating an African child development field and identify additional issues calling for the field's attention. The chapters collectively display a variety of African contexts and reflexive evidence of the authors' African cultural roots.…

  14. 76 FR 43649 - Board of Directors Meeting; African Development Foundation, Board of Directors Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-21

    ...; ] AFRICAN DEVELOPMENT FOUNDATION Board of Directors Meeting; African Development Foundation, Board of Directors Meeting Time: Tuesday, August 2, 2011, 9 a.m. to 12 p.m. Place: African Development...

  15. Women and the social construction of gender in African development.

    PubMed

    Kalu, A C

    1996-01-01

    Because a footnote of Marxism teaches that capitalism must first destroy primitive cultures that lack a dynamic social change mechanism and then rejuvenate them as modern industrialized states, the economic and cultural bases of social relationships in developing countries have been deemed irrelevant. In a similar way, Western feminist paradigms fail to acknowledge epistemological differences from those of African women. This article explores these contradictions and analyzes social change mechanisms within the Igbo culture in Africa that were stunted by colonialism. The first topic considered is the relationship of African literature (using Toni Morrison's "Beloved" as a point of reference) with sustainable African development and African women. The remainder of the article is devoted to an examination of the role of women in light of precolonial and colonial literary traditions. It is noted that continued use of Western feudal and capitalist terms for self-identification alienates Africans from Africa's problems. Traditional African thought assigned women the power to feed the family and to serve as protectors of children and society, and ancestral wisdom directed how societies responded to threats, took charge of their world, and resolved conflict. Problems faced by contemporary African researchers are shown to center on the dilemma faced by those who wish to design a program that analyzes the content of African development and provides contemporary solutions without completely deriving the program completely from contemporary thought. It is, thus, concluded that redefinition of the African development agenda must involve recognition of the essential role of African women as a change agent and a rearticulation of the male role within traditional thought. PMID:12292424

  16. Women and the social construction of gender in African development.

    PubMed

    Kalu, A C

    1996-01-01

    Because a footnote of Marxism teaches that capitalism must first destroy primitive cultures that lack a dynamic social change mechanism and then rejuvenate them as modern industrialized states, the economic and cultural bases of social relationships in developing countries have been deemed irrelevant. In a similar way, Western feminist paradigms fail to acknowledge epistemological differences from those of African women. This article explores these contradictions and analyzes social change mechanisms within the Igbo culture in Africa that were stunted by colonialism. The first topic considered is the relationship of African literature (using Toni Morrison's "Beloved" as a point of reference) with sustainable African development and African women. The remainder of the article is devoted to an examination of the role of women in light of precolonial and colonial literary traditions. It is noted that continued use of Western feudal and capitalist terms for self-identification alienates Africans from Africa's problems. Traditional African thought assigned women the power to feed the family and to serve as protectors of children and society, and ancestral wisdom directed how societies responded to threats, took charge of their world, and resolved conflict. Problems faced by contemporary African researchers are shown to center on the dilemma faced by those who wish to design a program that analyzes the content of African development and provides contemporary solutions without completely deriving the program completely from contemporary thought. It is, thus, concluded that redefinition of the African development agenda must involve recognition of the essential role of African women as a change agent and a rearticulation of the male role within traditional thought.

  17. Development of Interpersonal Coordination between Peers during a Drumming Task

    ERIC Educational Resources Information Center

    Endedijk, Hinke M.; Ramenzoni, Veronica C. O.; Cox, Ralf F. A.; Cillessen, Antonius H. N.; Bekkering, Harold; Hunnius, Sabine

    2015-01-01

    During social interaction, the behavior of interacting partners becomes coordinated. Although interpersonal coordination is well-studied in adults, relatively little is known about its development. In this project we explored how 2-, 3-, and 4-year-old children spontaneously coordinated their drumming with a peer. Results showed that all children…

  18. African American Biographies: A Collection Development Challenge.

    ERIC Educational Resources Information Center

    Woody, Donna

    2000-01-01

    Discusses the lack of African American biographies for elementary school libraries and reports the results of a study that surveyed publishers from the Children's Book Council. Examines book reviews, discusses the number of sports figures included, and considers problems with a lack of appropriate materials to support the curriculum. (LRW)

  19. DEVELOPMENT OF CHILDREN'S ABILITY TO COORDINATE PERSPECTIVES.

    ERIC Educational Resources Information Center

    MILLER, JACK W.

    THE PERSPECTIVE ABILITY TEST INVOLVED 285 CHILDREN BETWEEN 66 AND 155 MONTHS OF AGE. TO MEASURE ABILITY TO COORDINATE PERSPECTIVE, THE RESEARCHER BUILT A CIRCULAR TABLE WITH AN ISLAND DISC MODELED AND PAINTED TO REPRESENT WATERS AND MOUNTAINOUS LAND. TWENTY COLOR PHOTOGRAPHS WERE TAKEN FROM DIFFERENT EQUALLY SPACED VANTAGE POINTS. THE SUBJECTS…

  20. Development of the Coordination between Posture and Manual Control

    ERIC Educational Resources Information Center

    Haddad, Jeffrey M.; Claxton, Laura J.; Keen, Rachel; Berthier, Neil E.; Riccio, Gary E.; Hamill, Joseph; Van Emmerik, Richard E. A.

    2012-01-01

    Studies have suggested that proper postural control is essential for the development of reaching. However, little research has examined the development of the coordination between posture and manual control throughout childhood. We investigated the coordination between posture and manual control in children (7- and 10-year-olds) and adults during…

  1. The Origin and Development of the African Evaluation Guidelines

    ERIC Educational Resources Information Center

    Rouge, Jean-Charles

    2004-01-01

    In May 1990, the first evaluation seminar in Africa took place in Cote d'Ivoire. It was the first in a series of regional seminars on evaluation planned by the Development Assistance Committee (DAC) of the Organization for Economic Cooperation and Development (OECD). The seminar was jointly presented by the DAC and African Development Bank (ADB).…

  2. Accentuating River Border Conflicts and Water Privatization:The Southern African Development Community

    NASA Astrophysics Data System (ADS)

    Al-Essawi, Mohammed H. K.; Ntuli, Elijah M.

    The Southern African Development Community (SADC) is an international organization that has been in existence since 1980. Previously known as the Southern African Development Coordination Conference (SADCC), its primary aim was to coordinate development projects in order to lessen economic dependence on the then apartheid South Africa. Over the years, the coordination of such developmental projects has increasingly demanded a collective utilization of resources, such as energy, health and water sectors, among others. However, national boarders have also been pivotal in not only conflict management aspects, but also as protocolly agreed-upon component defining SADC`s contemporary international relations and legal regime. In the context of the accessibility and insufficiency of resources, our findings show that water as a resource has not only sparked inter-boarder issues, but also internal resistance from non-governmental organizations and major labor organizations in the SADC region. Policy formulation and implementation (under the international law umbrella) remain a greatest challenge in addressing the pressing issues of water privatization through political means.

  3. Pulmonary Function in Children with Development Coordination Disorder

    ERIC Educational Resources Information Center

    Wu, Sheng K.; Cairney, John; Lin, Hsiao-Hui; Li, Yao-Chuen; Song, Tai-Fen

    2011-01-01

    The purpose of this study was to compare pulmonary function in children with developmental coordination disorder (DCD) with children who are typically developing (TD), and also analyze possible gender differences in pulmonary function between these groups. The Movement ABC test was used to identify the movement coordination ability of children.…

  4. Coordination and Teacher Development in an Online Learning Environment

    ERIC Educational Resources Information Center

    Ernest, Pauline; Hopkins, Joseph

    2006-01-01

    This paper shares some of the experiences in online coordination and teacher development which have emerged in the English Language Department at the "Universitat Oberta de Catalunya". The advantages and disadvantages of coordination in an asynchronous computer-mediated environment form the backdrop to those issues which we consider to be vital,…

  5. Developing generalism in the South African context.

    PubMed

    Howe, Amanda C; Mash, Robert J; Hugo, Jannie F M

    2013-10-11

    The largest impact on the South African burden of disease will be made in community-based and primary healthcare (PHC) settings and not in referral hospitals. Medical generalism is an approach to the delivery of healthcare that routinely applies a broad and holistic perspective to the patient's problems and is a feature of PHC. A multi-professional team of generalists, who share similar values and principles, is needed to make this a reality. Ward-based outreach teams include community health workers and nurses with essential support from doctors. Expert generalists - family physicians - are required to support PHC as well as provide care at the district hospital. All require sufficient training, at scale, with greater collaboration and integration between training programmes. District clinical specialist teams are both an opportunity and a threat. The value of medical generalism needs to be explained, advocated and communicated more actively. 

  6. The Washington State System for Coordination of Staff Development. The Staff Development Coordination Study. Final Report.

    ERIC Educational Resources Information Center

    Washington Office of the State Superintendent of Public Instruction, Olympia.

    This report outlines the roles and responsibilities, pertaining to the improvement amd coordination of statewide teacher inservice, of the Superintendent of Public Instruction (SPI) in the state of Washington. After a field-based research study was conducted, a system was devised by which the SPI can improve coordination of staff development…

  7. Recent developments in methods for identifying reaction coordinates.

    PubMed

    Li, Wenjin; Ma, Ao

    2014-01-01

    In the study of rare events in complex systems with many degrees of freedom, a key element is to identify the reaction coordinates of a given process. Over recent years, a number of methods and protocols have been developed to extract the reaction coordinates based on limited information from molecular dynamics simulations. In this review, we provide a brief survey over a number of major methods developed in the past decade, some of which are discussed in greater detail, to provide an overview of the problems that are partially solved and challenges that still remain. A particular emphasis has been placed on methods for identifying reaction coordinates that are related to the committor.

  8. Linguistic Struggles within and beyond the Southern African Development Community

    ERIC Educational Resources Information Center

    Bagwasi, Mompoloki Mmangaka

    2012-01-01

    This paper argues that the linguistic struggles faced by the Southern African Development Community (the SADC) represent common linguistic struggles found in Africa and the world where some languages are accused of dominating, stifling and suppressing others. However, the language situation within the SADC is interesting because it offers us a…

  9. Leadership Development and the African American Male College Student Experience

    ERIC Educational Resources Information Center

    Oaks, D'Arcy John; Duckett, Kirstan; Suddeth, Todd; Kennedy-Phillips, Lance

    2013-01-01

    Qualitative interviews were employed to assess the effectiveness of a leadership program geared toward African American male personal and professional development, and to examine the relationship between program participation and connectedness. Elements of both social engagement (mentoring and being mentored, peer-to-peer relationships, and…

  10. 78 FR 22225 - Meeting: African Development Foundation, Board of Directors Executive Session Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    ...; ] AFRICAN DEVELOPMENT FOUNDATION Board of Directors Executive Session Meeting Meeting: African Development Foundation, Board of Directors Executive Session Meeting Time: Tuesday, April 23, 2013 11:15 a.m. to 2:15...

  11. Cancer care coordination: building a platform for the development of care coordinator roles and ongoing evaluation.

    PubMed

    Freijser, Louise; Naccarella, Lucio; McKenzie, Rosemary; Krishnasamy, Meinir

    2015-01-01

    Continuity of care is integral to the quality and safety of care provided to people with cancer and their carers. Further evidence is required to examine the contribution Nurse Cancer Care Coordinator (NCCC) roles make in improving the continuity. The aim of the present study was to clarify the assumptions underpinning the NCCC roles and provide a basis for ongoing evaluation. The project comprised a literature review and a qualitative study to develop program logic. The participants who were purposively sampled included policy makers, practitioners, patient advocates, and researchers. Both the literature and participant reports found that NCCC roles are diverse and responsive to contextual influences to coordinate care at the individual (patient), organisational, and systems levels. The application of the program logic for the development of NCCC roles was explored. The conceptualisation of NCCC roles was also examined in relation to Boundary Spanning and Relational Coordination theory. Further research is required to examine how NCCCs contribute to improving equity, safety, quality and coordination of care. The project has implications for research, policy and practice, and makes explicit existing assumptions to provide a platform for further development and evaluation of these roles. PMID:26509202

  12. 22 CFR 1508.635 - May the African Development Foundation settle a debarment or suspension action?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true May the African Development Foundation settle a debarment or suspension action? 1508.635 Section 1508.635 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION... Actions § 1508.635 May the African Development Foundation settle a debarment or suspension action? Yes,...

  13. 22 CFR 1508.635 - May the African Development Foundation settle a debarment or suspension action?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 2 2013-04-01 2009-04-01 true May the African Development Foundation settle a debarment or suspension action? 1508.635 Section 1508.635 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION... Actions § 1508.635 May the African Development Foundation settle a debarment or suspension action? Yes,...

  14. 22 CFR 1508.635 - May the African Development Foundation settle a debarment or suspension action?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 2 2012-04-01 2009-04-01 true May the African Development Foundation settle a debarment or suspension action? 1508.635 Section 1508.635 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION... Actions § 1508.635 May the African Development Foundation settle a debarment or suspension action? Yes,...

  15. 22 CFR 1508.635 - May the African Development Foundation settle a debarment or suspension action?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 2 2014-04-01 2014-04-01 false May the African Development Foundation settle a debarment or suspension action? 1508.635 Section 1508.635 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION... Actions § 1508.635 May the African Development Foundation settle a debarment or suspension action? Yes,...

  16. 22 CFR 1508.635 - May the African Development Foundation settle a debarment or suspension action?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 2 2011-04-01 2009-04-01 true May the African Development Foundation settle a debarment or suspension action? 1508.635 Section 1508.635 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION... Actions § 1508.635 May the African Development Foundation settle a debarment or suspension action? Yes,...

  17. Coordinated development of leading biomass pretreatment technologies.

    PubMed

    Wyman, Charles E; Dale, Bruce E; Elander, Richard T; Holtzapple, Mark; Ladisch, Michael R; Lee, Y Y

    2005-12-01

    For the first time, a single source of cellulosic biomass was pretreated by leading technologies using identical analytical methods to provide comparative performance data. In particular, ammonia explosion, aqueous ammonia recycle, controlled pH, dilute acid, flowthrough, and lime approaches were applied to prepare corn stover for subsequent biological conversion to sugars through a Biomass Refining Consortium for Applied Fundamentals and Innovation (CAFI) among Auburn University, Dartmouth College, Michigan State University, the National Renewable Energy Laboratory, Purdue University, and Texas A&M University. An Agricultural and Industrial Advisory Board provided guidance to the project. Pretreatment conditions were selected based on the extensive experience of the team with each of the technologies, and the resulting fluid and solid streams were characterized using standard methods. The data were used to close material balances, and energy balances were estimated for all processes. The digestibilities of the solids by a controlled supply of cellulase enzyme and the fermentability of the liquids were also assessed and used to guide selection of optimum pretreatment conditions. Economic assessments were applied based on the performance data to estimate each pretreatment cost on a consistent basis. Through this approach, comparative data were developed on sugar recovery from hemicellulose and cellulose by the combined pretreatment and enzymatic hydrolysis operations when applied to corn stover. This paper introduces the project and summarizes the shared methods for papers reporting results of this research in this special edition of Bioresource Technology.

  18. Development of an International School Nurse Asthma Care Coordination Model

    PubMed Central

    Garwick, Ann W.; Svavarsdóttir, Erla Kolbrun; Seppelt, Ann M.; Looman, Wendy S.; Anderson, Lori S.; Örlygsdóttir, Brynja

    2015-01-01

    Aim To identify and compare how school nurses in Reykjavik, Iceland and St. Paul, Minnesota coordinated care for youth with asthma (ages 10–18) and to develop an asthma school nurse care coordination model. Background Little is known about how school nurses coordinate care for youth with asthma in different countries. Design A qualitative descriptive study design using focus group data. Methods Six focus groups with 32 school nurses were conducted in Reykjavik (n=17) and St. Paul (n=15) using the same protocol between September 2008 – January 2009. Descriptive content analytic and constant comparison strategies were used to categorize and compare how school nurses coordinated care, which resulted in the development of an International School Nurse Asthma Care Coordination Model. Findings Participants in both countries spontaneously described a similar asthma care coordination process that involved information gathering, assessing risk for asthma episodes, prioritizing health care needs and anticipating and planning for student needs at the individual and school levels. This process informed how they individualized symptom management, case management and/or asthma education. School nurses played a pivotal part in collaborating with families, school and health care professionals to ensure quality care for youth with asthma. Conclusions Results indicate a high level of complexity in school nurses’ approaches to asthma care coordination that were responsive to the diverse and changing needs of students in school settings. The conceptual model derived provides a framework for investigators to use in examining the asthma care coordination process of school nurses in other geographic locations. PMID:25223389

  19. Cilia and coordination of signaling networks during heart development

    PubMed Central

    Koefoed, Karen; Veland, Iben Rønn; Pedersen, Lotte Bang; Larsen, Lars Allan; Christensen, Søren Tvorup

    2014-01-01

    Primary cilia are unique sensory organelles that coordinate a wide variety of different signaling pathways to control cellular processes during development and in tissue homeostasis. Defects in function or assembly of these antenna-like structures are therefore associated with a broad range of developmental disorders and diseases called ciliopathies. Recent studies have indicated a major role of different populations of cilia, including nodal and cardiac primary cilia, in coordinating heart development, and defects in these cilia are associated with congenital heart disease. Here, we present an overview of the role of nodal and cardiac primary cilia in heart development. PMID:24345806

  20. The Professional Development of High School Chemistry Coordinators

    ERIC Educational Resources Information Center

    Hofstein, Avi; Carmeli, Miriam; Shore, Relly

    2004-01-01

    The implementation of new content and pedagogical standards in science education necessitates intensive, long-term professional development of science teachers. In this paper, we describe the rationale and structure of a comprehensive and intensive professional development program of school-based leaders, namely school chemistry coordinators. The…

  1. The income-climate trap of health development: a comparative analysis of African and Non-African countries.

    PubMed

    Tang, Kam Ki; Petrie, Dennis; Rao, D S Prasada

    2009-10-01

    This article conducts a comparative analysis of the interrelationship between climate, life expectancy and income between African and non-African countries. To put the analysis in a broader context of development, the paper develops an income-climate trap model that explains the multi-directional interaction between income, climate and life expectancy. It is suggested that the interaction can give rise to either a virtuous cycle of prosperity or a vicious cycle of poverty. Applying the model to a data set of 158 countries, we find that climate is a more important determinant of life expectancy in African countries than in non-African countries. We provide further empirical evidence that while climate is important in determining both life expectancy and income, income can in turn moderate the adverse effects of climate on life expectancy. In the past two decades, the income level of non-African countries has grown significantly while that of African countries has largely been stagnant, implying that the future development of African countries remains highly vulnerable to adverse climatic conditions. These findings have important implications in the context of climate change, as global warming is likely to create worsening climatic conditions that could see many less developed countries sinking deeper into an income-climate trap of underdevelopment in health.

  2. Using ICTs (Educationally) for Development in an African Context: Possibilities and Limitations

    ERIC Educational Resources Information Center

    Carrim, Nazir; Taruvinga, Mandi

    2015-01-01

    This article examines the possibilities and limitations of using ICTs for development in an African context from an education perspective. Although we provide an account of the Pan-African Agenda on integrating ICTs, which covers many countries on the African continent, our focus is specifically on using ICTs for development in a South African…

  3. Biomass energy use in developing countries: An African perspective

    SciTech Connect

    Karekezi, S.; Ewagata, E.

    1994-09-01

    Biomass forms the bulk of the energy supply of the developing world with the largest share consumed in the household sector as either fuelwood or charcoal for cooking, lighting and space heating. However there are a number of constraints facing the use of biomass if it is to be sustainable. Stephen Karekezi and Esther Ewagata of the African Energy Policy Research Network (AFREPREN) outline these constraints and discuss the modernisation of the traditional technologies now underway.

  4. A Case Study of Coordination in Distributed Agile Software Development

    NASA Astrophysics Data System (ADS)

    Hole, Steinar; Moe, Nils Brede

    Global Software Development (GSD) has gained significant popularity as an emerging paradigm. Companies also show interest in applying agile approaches in distributed development to combine the advantages of both approaches. However, in their most radical forms, agile and GSD can be placed in each end of a plan-based/agile spectrum because of how work is coordinated. We describe how three GSD projects applying agile methods coordinate their work. We found that trust is needed to reduce the need of standardization and direct supervision when coordinating work in a GSD project, and that electronic chatting supports mutual adjustment. Further, co-location and modularization mitigates communication problems, enables agility in at least part of a GSD project, and renders the implementation of Scrum of Scrums possible.

  5. Recent developments in methods for identifying reaction coordinates

    PubMed Central

    Li, Wenjin; Ma, Ao

    2014-01-01

    In the study of rare events in complex systems with many degrees of freedom, a key element is to identify the reaction coordinates of a given process. Over recent years, a number of methods and protocols have been developed to extract the reaction coordinates based on limited information from molecular dynamics simulations. In this review, we provide a brief survey over a number of major methods developed in the past decade, some of which are discussed in greater detail, to provide an overview of the problems that are partially solved and challenges that still remain. A particular emphasis has been placed on methods for identifying reaction coordinates that are related to the committor. PMID:25197161

  6. Bioenergy for sustainable development: An African context

    NASA Astrophysics Data System (ADS)

    Mangoyana, Robert Blessing

    This paper assesses the sustainability concerns of bioenergy systems against the prevailing and potential long term conditions in Sub-Saharan Africa with a special attention on agricultural and forestry waste, and cultivated bioenergy sources. Existing knowledge and processes about bioenergy systems are brought into a “sustainability framework” to support debate and decisions about the implementation of bioenergy systems in the region. Bioenergy systems have been recommended based on the potential to (i) meet domestic energy demand and reduce fuel importation (ii) diversify rural economies and create employment (iii) reduce poverty, and (iv) provide net energy gains and positive environmental impacts. However, biofuels will compete with food crops for land, labour, capital and entrepreneurial skills. Moreover the environmental benefits of some feedstocks are questionable. These challenges are, however, surmountable. It is concluded that biomass energy production could be an effective way to achieve sustainable development for bioenergy pathways that (i) are less land intensive, (ii) have positive net energy gains and environmental benefits, and (iii) provide local socio-economic benefits. Feasibility evaluations which put these issues into perspective are vital for sustainable application of agricultural and forest based bioenergy systems in Sub-Saharan Africa. Such evaluations should consider the long run potential of biofuels accounting for demographic, economic and technological changes and the related implications.

  7. Coordinated Networks--A Method for Community Development.

    ERIC Educational Resources Information Center

    Sorter, Bruce W.; Simpkinson, Charles H.

    1979-01-01

    Describes a strategy for a community development program that was to identify and connect needs and services through coordinated networks of organized citizens, businesses, agency staff, and local government. Reports that the strategy resulted in such programs as a county information service, a family life center, an interagency council, and a…

  8. Impact of Career Development Program Upon Local Coordinators. Final Report.

    ERIC Educational Resources Information Center

    Mulford, Charles L.; And Others

    The general objective of this study was to investigate the effectiveness of the OCD Career Development Program. The specific objectives were to determine the program's impact on the local civil defense coordinator's knowledge of and ability to build and operate a viable local civil defense organization and to link the official (vertical) civil…

  9. Mentoring and Professional Identity Development for African American Female Doctoral Students: An Exploratory Study

    ERIC Educational Resources Information Center

    Curry, Nettavia Doreen

    2011-01-01

    This dissertation examines the impact mentoring relationships, between African American women doctoral students and faculty members, has on the students' professional identity development. Of particular interest is an examination of whether matched mentoring relationships between African American women doctoral students and African American female…

  10. Impact of College Environments on the Spiritual Development of African American Students

    ERIC Educational Resources Information Center

    Weddle-West, Karen; Hagan, Waldon Joseph; Norwood, Kristie M.

    2013-01-01

    This study focused on the impact of college environments on the spiritual development of African American students. Using the Armstrong Measure of Spirituality (AMOS) survey administered to 125 African American college students, the study sought to ascertain whether or not there were differences in spirituality as reported by African American…

  11. The Development of an African-Centered School--The First 20 Years

    ERIC Educational Resources Information Center

    Squire, Michelle Suzette

    2012-01-01

    This research study is a case study of the development of an African-centered school over a 20-year period. The study describes how the kindergarten-through-eighth-grade institution was established. Interview questions focused on: 1. Establishment of an African-centered institution 2. Challenges of setting up an African-centered institution 3.…

  12. The Professional Development of High School Chemistry Coordinators

    NASA Astrophysics Data System (ADS)

    Hofstein, Avi; Carmeli, Miriam; Shore, Relly

    2004-02-01

    The implementation of new content and pedagogical standards in science education necessitates intensive, long-term professional development of science teachers. In this paper, we describe the rationale and structure of a comprehensive and intensive professional development program of school-based leaders, namely school chemistry coordinators. The year-long program was designed so that the chemistry teachers who enrolled in the program were able to develop in three interrelated aspects: content knowledge, pedagogical content knowledge, and leadership ability. Several strategies for the development of these aspects were adopted from Loucks-Horsley, Hewson, Love, & Stiles (1998). The evaluation of the program focused on the changes that participating teachers underwent regarding their personal beliefs and their functioning as school chemistry coordinators in their schools.

  13. African women, industrialization and another development. A global perspective.

    PubMed

    Steady, F C

    1982-01-01

    Historically, the women of Africa have been differentially integrated into the world economic system, serving primarily as a labor reserve and a mainstay for the subsistence and reproductive sectors. If and when necessary, female proletarianization can come into effect. African women, by virtue of their strategic role in traditional food systems, have acquired certain skills compatible with labor intensive food processing industries. Consequently, in some countries they have been involved in the handling, processing, and packing of food. In many 3rd world nations regulations protecting minimum wage levels do not exist and collective bargaining activities are not strongly in force. Economic hardship and the desperate need to survive can lead some groups to accept even lower wages. Consequently, although the employment of women at lower wages violates the principle of equal pay for equal work, agroindustries with monopolies can deliberately and with impunity hire women at lower wages than men. In general, when women are hired in industries the nature of their employment is precarious, frequently being of a casual and seasonal nature and in greatest demand during peak periods. In an effort to understand the implications of industrialization for African women a global perspective is necessary, for at present the incorporation of the African women in direct industrialization is minimal. Racism has played an important role in the exploitation of the African continent, and no serious study of class and gender inequality in Africa can overlook that important fact. Numerous studies have shown how industry perpetuates the sexual division of labor. Even in the industrialized nations, women often have held the least paid and most precarious jobs in industry. Women's vulnerability is further worsened by several factors, the most obvious being their reproductive capabilities. In addition to being more vulnerable to industrial hazards, their employment can be truncated by

  14. African women, industrialization and another development. A global perspective.

    PubMed

    Steady, F C

    1982-01-01

    Historically, the women of Africa have been differentially integrated into the world economic system, serving primarily as a labor reserve and a mainstay for the subsistence and reproductive sectors. If and when necessary, female proletarianization can come into effect. African women, by virtue of their strategic role in traditional food systems, have acquired certain skills compatible with labor intensive food processing industries. Consequently, in some countries they have been involved in the handling, processing, and packing of food. In many 3rd world nations regulations protecting minimum wage levels do not exist and collective bargaining activities are not strongly in force. Economic hardship and the desperate need to survive can lead some groups to accept even lower wages. Consequently, although the employment of women at lower wages violates the principle of equal pay for equal work, agroindustries with monopolies can deliberately and with impunity hire women at lower wages than men. In general, when women are hired in industries the nature of their employment is precarious, frequently being of a casual and seasonal nature and in greatest demand during peak periods. In an effort to understand the implications of industrialization for African women a global perspective is necessary, for at present the incorporation of the African women in direct industrialization is minimal. Racism has played an important role in the exploitation of the African continent, and no serious study of class and gender inequality in Africa can overlook that important fact. Numerous studies have shown how industry perpetuates the sexual division of labor. Even in the industrialized nations, women often have held the least paid and most precarious jobs in industry. Women's vulnerability is further worsened by several factors, the most obvious being their reproductive capabilities. In addition to being more vulnerable to industrial hazards, their employment can be truncated by

  15. Migration dynamics, entrepreneurship, and African development: Lessons from Malawi

    PubMed Central

    Thomas, Kevin J. A.; Inkpen, Christopher

    2014-01-01

    Using data from Malawi, this study situates the discourse on migration, entrepreneurship, and development within the context of Africa’s social realities. It examines self-employment differences among three groups of migrants and corresponding group differences in agricultural and non-agricultural self-employment. International migrants are found to be more engaged in self-employment than internal-migrants. However, our results suggest that previous findings on the development-related contributions of returning migrants from the West need to be appropriately contextualized. When returnees from the West invest in self-employment, they typically shy away from Africa’s largest economic sector - agriculture. In contrast, levels of self-employment, especially in agricultural self-employment, are highest among returning migrants and immigrants from other African countries, especially from those nearby. We also underscore the gendered dimensions of migrants’ contribution to African development by demonstrating that female migrants are more likely to be self-employed in agriculture than male migrants. Furthermore, as human-capital increases, migrants are more likely to concentrate their self-employment activities in non-agricultural activities and not in the agricultural sector. The study concludes by using these findings to discuss key implications for policy and future research. PMID:25598569

  16. Pre-colonial Ethnic Institutions and Contemporary African Development*

    PubMed Central

    Michalopoulos, Stelios; Papaioannou, Elias

    2013-01-01

    We investigate the role of deeply-rooted pre-colonial ethnic institutions in shaping comparative regional development within African countries. We combine information on the spatial distribution of ethnicities before colonization with regional variation in contemporary economic performance, as proxied by satellite images of light density at night. We document a strong association between pre-colonial ethnic political centralization and regional development. This pattern is not driven by differences in local geographic features or by other observable ethnic-specific cultural and economic variables. The strong positive association between pre-colonial political complexity and contemporary development obtains also within pairs of adjacent ethnic homelands with different legacies of pre-colonial political institutions. PMID:25089052

  17. Building up indigenous technological capabilities in African developing countries

    SciTech Connect

    Lubunga, P.S.

    1985-01-01

    For all the vast natural resources and the praiseworthy efforts of governments and peoples, the African economy still remains basically underdeveloped. Faced with this situation, there have been increased awareness and concern in recent years among political leaders, decision-makers, and socioeconomic planners of the fact that the chronic low-level productivity in almost all spheres of economic activity in that region can be attributed, to a large extent, to the low level of indigenous capability and appropriate utilization of science and technology. Few countries in Africa, however, as yet have a science and technology policy formulated toward long-term goals and objectives, and for overall economic and social development. There is, therefore, an urgent need to develop progressively the systems and methodology for identifying, selecting, and planning indigenous scientific and technological activity. International cooperation can be useful, but only within the context of a strong national capability. 14 references.

  18. Why Patient Centered Care Coordination Is Important in Developing Countries?

    PubMed Central

    Luna, D.; Marcelo, A.; Househ, M.; Mandirola, H.; Curioso, W.; Pazos, P.; Villalba, C.

    2015-01-01

    Summary Patient Centered Care Coordination (PCCC) focuses on the patient health care needs. PCCC involves the organization, the patients and their families, that must coordinate resources in order to accomplish the goals of PCCC. In developing countries, where disparities are frequent, PCCC could improve clinical outcomes, costs and patients satisfaction. Objective the IMIA working group Health Informatics for Development analyzes the benefits, identifies the barriers and proposes strategies to reach PCCC. Methods Discussions about PCCC emerged from a brief guide that posed questions about what is PCCC, why consider PCCC important, barriers to grow in this direction and ask about resources considered relevant in the topic. Results PCCC encompasses a broad definition, includes physical, mental, socio-environmental and self care. Even benefits are proved, in developing countries the lack of a comprehensive and integrated healthcare network is one of the main barriers to reach this objective. Working hard to reach strong health policies, focus on patients, and optimizing the use of resources could improve the performance in the devolvement of PCCC programs. International collaboration could bring benefits. We believe information IT, and education in this field will play an important role in PCCC. Conclusion PCCC in developing countries has the potential to improve quality of care. Education, IT, policies and cultural issues must be addressed in an international collaborative context in order to reach this goal. PMID:26123907

  19. The Story of South African Academic Development in International Perspective: Have We Lost the Plot?

    ERIC Educational Resources Information Center

    Volbrecht, T.

    2003-01-01

    South African Academic Development (AD) emerged as a liberatory educational and social movement in the 1980s. AD (often called educational development) has burgeoned as an international phenomenon, but with a focus on quality rather than on liberation. South African AD now seems to be struggling to construct its post-apartheid identity, if one…

  20. Career Development for African American and Latina Females. ERIC/CUE Digest, Number 125

    ERIC Educational Resources Information Center

    Weiler, Jeanne

    Low-income African American and Latina adolescent females need extensive support for developing and implementing career plans. This digest discusses ways schools and other institutions can provide an education that furthers career development. Interventions that have been shown to be effective with disadvantaged African American and Latina female…

  1. Racial Identity Development and Academic Achievement of Academically Gifted African American Students: Implications for School Counselors

    ERIC Educational Resources Information Center

    Spencer, Natalie F.; Dowden, Angel Riddick

    2014-01-01

    Gifted African American students are underrepresented and underserved in gifted education. The current article provides an overview of proper identification, racial identity development implications, psycho-social concerns and the importance of family involvement in the development of gifted African American students. A case study is presented to…

  2. Changing Urbanization Trends and Human Needs in Developing African Nations.

    ERIC Educational Resources Information Center

    Underwood, Willard A.; Ferguson, Ralph E.

    The purpose of this paper is to analyze the increasing migration of African tribal members to urban centers and the resulting redefinition of cultural norms, social pressures, and human needs. First, several misconceptions about African societies are examined by briefly reviewing Africa's tribal history. Next, the phenomenon of tribalism is…

  3. The Effectiveness of Career Development Seminars on African American Premedical Students: A Program Evaluation Using the Medical Career Development Inventory.

    ERIC Educational Resources Information Center

    Henry, Paul; And Others

    1992-01-01

    Examined impact of Medical Education Preparatory Program, structured career planning program, on career maturity scores of 61 African-American premedical students as measured by Medical Career Development Inventory (MCDI). Results revealed significant increases in career development levels, as measured by MCDI, of African-American students after…

  4. A Teacher Proposed Heuristic for ICT Professional Teacher Development and Implementation in the South African Context

    ERIC Educational Resources Information Center

    du Plessis, Andre; Webb, Paul

    2012-01-01

    This qualitative interpretive exploratory case study investigated a sample of South African teachers' perceptions of the requirements for successful implementation of Information and Communication Technology (ICT) Professional Teacher Development (PTD) within disadvantaged South African township schools in the Port Elizabeth district in South…

  5. Language Policy and Practice in the Multilingual Southern African Development Community

    ERIC Educational Resources Information Center

    Mooko, Theophilus

    2009-01-01

    This study explores the language policy and practice of the Southern African Development Community (SADC), an African regional economic organisation made up of 14 member states (Angola, Botswana, Democratic Republic of Congo, Lesotho, Madagascar, Malawi, Mauritius, Mozambique, Namibia, South Africa, Swaziland, United Republic of Tanzania, Zambia…

  6. Contextual Influences on Gendered Racial Identity Development of African American Young Women

    ERIC Educational Resources Information Center

    Thomas, Anita Jones; Hoxha, Denada; Hacker, Jason Daniel

    2013-01-01

    The aim of the study was to identify the contextual factors and socialization experiences most salient to the identity development of African American girls. Seventeen African American young women participated in dyadic focus groups. Themes that emerged included exposure to stereotypes, negative classroom environments, and parental and peer…

  7. African American Males and Literacy Development in Contexts That Are Characteristically Urban

    ERIC Educational Resources Information Center

    Tatum, Alfred W.; Muhammad, Gholnecsar E.

    2012-01-01

    Advancing the literacy development of African American males in contexts that are characteristically urban has been a challenging task for educators across the P-12 spectrum. Frames that have been traditionally used to improve the reading achievement of African American males have not reversed trends in reading achievement that find many of these…

  8. Reflections on Academic Development: What We Can Learn from the South African Experience. Technical Report.

    ERIC Educational Resources Information Center

    Epstein, Ruth

    A study examined academic literacy in high-risk South African students entering postsecondary education, and the relationship of academic literacy to instructional development. Data were gathered in discussions with academic staff at South African universities and technikons and at the University of Saskatchewan. The report begins with background…

  9. Anxiety Psychopathology in African American Adults: Literature Review and Development of an Empirically Informed Sociocultural Model

    ERIC Educational Resources Information Center

    Hunter, Lora Rose; Schmidt, Norman B.

    2010-01-01

    In this review, the extant literature concerning anxiety psychopathology in African American adults is summarized to develop a testable, explanatory framework with implications for future research. The model was designed to account for purported lower rates of anxiety disorders in African Americans compared to European Americans, along with other…

  10. Development of infant leg coordination: Exploiting passive torques.

    PubMed

    Sargent, Barbara; Scholz, John; Reimann, Hendrik; Kubo, Masayoshi; Fetters, Linda

    2015-08-01

    Leg joint coordination systematically changes over the first months of life, yet there is minimal data on the underlying change in muscle torques that might account for this change in coordination. The purpose of this study is to investigate the contribution of torque changes to early changes in leg joint coordination. Kicking actions were analyzed of 10 full-term infants between 6 and 15-weeks of age using three-dimensional kinematics and kinetics. We found 11 of 15 joint angle pairs demonstrated a change from more in-phase intralimb coordination at 6-weeks to less in-phase coordination at 15-weeks. Although the magnitude of joint torques normalized to the mass of the leg remained relatively consistent, we noted more complex patterns of torque component contribution across ages. By focusing on the change in torques associated with hip-knee joint coordination, we found that less in-phase hip-knee joint coordination at 15-weeks was associated with decreased influence of knee muscle torque and increased influence of knee gravitational and motion-dependent torques, supporting that infants coordinate hip muscle torque with passive knee gravitational and motion-dependent torques to generate kicks with reduced active knee muscle torque. We propose that between 6 and 15-weeks of age less in-phase hip-knee coordination emerges as infants exploit passive dynamics in the coordination of hip and knee motions.

  11. Coordinated observations of the magnetosphere - The development of a substorm.

    NASA Technical Reports Server (NTRS)

    Mende, S. B.; Sharp, R. D.; Shelley, E. G.; Haerendel, G.; Hones, E. W.

    1972-01-01

    Coordinated observations of a substorm are reported by using data from all-sky camera (ASCA) stations near the northern conjugate of the ATS 5 geostationary satellite, plasma and magnetic-field experiments on the ATS 5 satellite, Vela 5B at 18 earth radii in the magnetotail, the Heos 1 interplanetary probe, and ground-based magnetograms. The substorm event occurred after a very quiet day and was preceded by a development period during which the interplanetary field turned southward and the plasma energy density increased near the earth on the nightside. This period was also evidenced by a depression of the midlatitude H component of the geomagnetic field at the earth's surface. The auroral breakup was preceded by the appearance of quiet arcs, the leveling off of the plasma energy density increase at ATS, and the disappearance of the tail plasma at 18 earth radii.

  12. 22 CFR 1508.135 - May the African Development Foundation exclude a person who is not currently participating in a...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true May the African Development Foundation exclude a... Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 1508.135 May the African Development Foundation exclude a person who is not...

  13. 22 CFR 1508.135 - May the African Development Foundation exclude a person who is not currently participating in a...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 2 2011-04-01 2009-04-01 true May the African Development Foundation exclude a... Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 1508.135 May the African Development Foundation exclude a person who is not...

  14. 22 CFR 1508.135 - May the African Development Foundation exclude a person who is not currently participating in a...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 2 2014-04-01 2014-04-01 false May the African Development Foundation exclude....135 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 1508.135 May the African Development Foundation exclude a person who is not...

  15. 22 CFR 1508.135 - May the African Development Foundation exclude a person who is not currently participating in a...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 2 2013-04-01 2009-04-01 true May the African Development Foundation exclude a... Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 1508.135 May the African Development Foundation exclude a person who is not...

  16. 22 CFR 1508.135 - May the African Development Foundation exclude a person who is not currently participating in a...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 2 2012-04-01 2009-04-01 true May the African Development Foundation exclude a... Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 1508.135 May the African Development Foundation exclude a person who is not...

  17. Development and validation of a diabetes self-management instrument for older African-Americans.

    PubMed

    McCaskill, Gina M; Bolland, Kathleen A; Burgio, Kathryn L; Leeper, James

    2016-01-01

    The objective of this study was to develop and validate a new diabetes self-management instrument for older African-Americans 65 years of age and older. The Self-Care Utility Geriatric African-American Rating (SUGAAR) was developed using the American Diabetes Association's standards for the management of type 2 diabetes in older adults and cognitive interviews with older African-Americans. The instrument underwent extensive review by a panel of experts, two rounds of cognitive interviews, and a pilot test before it was administered in an interview format to 125 community-dwelling older African-Americans. The instrument demonstrated content validity and significant, but modest, convergent validity with items from an established diabetes self-management instrument. Social workers and health care professionals can use the SUGARR to assess diabetes self-management and to identify areas for education and support for older African-Americans with type 2 diabetes.

  18. Variation in enamel development of South African fossil hominids.

    PubMed

    Lacruz, Rodrigo S; Rozzi, Fernando Ramirez; Bromage, Timothy G

    2006-12-01

    Dental tissues provide important insights into aspects of hominid palaeobiology that are otherwise difficult to obtain from studies of the bony skeleton. Tooth enamel is formed by ameloblasts, which demonstrate daily secretory rhythms developing tissue-specific structures known as cross striations, and longer period markings called striae of Retzius. These enamel features were studied in the molars of two well known South African hominid species, Australopithecus africanus and Paranthropus robustus. Using newly developed portable confocal microscopy, we have obtained cross striation periodicities (number of cross striations between adjacent striae) for the largest sample of hominid teeth reported to date. These data indicate a mean periodicity of seven days in these small-bodied hominids. Important differences were observed in the inferred mechanisms of enamel development between these taxa. Ameloblasts maintain high rates of differentiation throughout cervical enamel development in P. robustus but not in A. africanus. In our sample, there were fewer lateral striae of Retzius in P. robustus than in A. africanus. In a molar of P. robustus, lateral enamel formed in a much shorter time than cuspal enamel, and the opposite was observed in two molars of A. africanus. In spite of the greater occlusal area and enamel thickness of the molars of both fossil species compared with modern humans, the total crown formation time of these three fossil molars was shorter than the corresponding tooth type in modern humans. Our results provide support for previous conclusions that molar crown formation time was short in Plio-Pleistocene hominids, and strongly suggest the presence of different mechanisms of amelogenesis, and thus tooth development, in these taxa.

  19. African-American lesbian identity management and identity development in the context of family and community.

    PubMed

    Miller, Shannon J

    2011-01-01

    Don't Ask, Don't Tell is gaining attention in family studies literature as a cultural specific context to understand lesbian, gay, and bisexual visibility in African-American families and communities. This policy suggests that sexual minorities are accepted within African-American families and communities as long as they do not label themselves or acknowledge publicly that they engage in same-sex relationships. The narratives of two African-American lesbians (aged 26 and 27 years) are chronicled in the present study to reveal their lesbian identity development, lesbian identity management, and how they defined and navigated Don't Ask, Don't Tell. They encountered challenges and successes in a quest to find communities that would embrace and affirm their multiple marginalized identities. Their stories are offered as a point of entry to further inquiry concerning African-American lesbian visibility and identity proclamation within African-American families and communities.

  20. Final Report: African Power/Energy and Environmental Development Plan, July 1, 1994 - August 21, 1999

    SciTech Connect

    Butler, John M.

    1999-08-21

    In 1994 AEF signed a Cooperative Agreement with DOE to address a program called the African Power /Energy and Environmental Development Plan. The Program initially addressed five area: (1) Historical Black Colleges and Universities Energy/Environmental Program; (2) The Department of Energy and United States Private Industry Africa Program; (3) The Annual United States Energy Study Tour; (4) South African Training Program, and (5) South African Environmental Program. The programs were implemented in conjunction with DOE, institutions, agencies and the private sector support in the USA and within African nations. AEF has worked with government and technical representatives from 13 African nations and expanded the program to address sponsorship of South African students in Historical Black Colleges and Universities, supporting DOE trade missions through participation and planning, and giving presentations in the U.S., and Africa regarding business opportunities in the African energy sector. The programs implemented have also opened doors for the US private sector to seek business opportunities in Africa and for African nations to gain exposure to US products and services.

  1. Multinational, freshwater biomonitoring programs in the developing world: lessons learned from African and Southeast Asian river surveys.

    PubMed

    Resh, Vincent H

    2007-05-01

    Biomonitoring programs are widely used in developed countries. They also offer many advantages in assessing ecological consequences of perturbations in developing countries, including reducing the equipment-operation, maintenance, and training costs associated with physicochemical monitoring. Three case histories of river biomonitoring using freshwater organisms (fish, benthic macroinvertebrates, diatoms, zooplankton) are described that involve (1) documentation of environmental effects from long-term, large-scale applications of insecticides to control insect-vectors of river blindness (onchocerciasis) in 11 West African countries; (2) water quality assessments and restoration planning in and around national parks in three East African countries; and (3) evaluation of overall ecological health of the Lower Mekong River in four Southeast Asian countries. As in developed countries, benthic macroinvertebrates are the organisms most widely used in biomonitoring in developing countries. Conflicting opinions of system resilience and whether expected changes are within natural variation may result in differences in underlying hypotheses proposed, study designs implemented, and study execution; each may lead to uncorrectable bias. Direct transfers of approaches used from developed to developing countries are often appropriate; however, techniques dependent on pollution-tolerance values are often region specific and not transferable. Typically expressed concerns about applications of biomonitoring in developing countries include poor coordination among agencies; lack of legislation, identification keys, and trained personnel; and incomplete information on how tropical rivers function. Problems are real but solvable, as evident from accomplishments in several multicountry programs in developing countries. Developed countries requiring coordinated monitoring of international rivers may benefit from examining successful programs under way in developing countries.

  2. Glaucoma Medication Adherence among African Americans: Program Development

    PubMed Central

    Dreer, Laura E.; Girkin, Christopher A.; Campbell, Lisa; Wood, Andy; Gao, Liyan; Owsley, Cynthia

    2014-01-01

    Purpose To elucidate barriers and facilitators related to glaucoma medication adherence among African Americans (AA) with glaucoma and to elicit input from a community-based participatory research team in order to guide the development of a culturally informed, health promotion program for improving glaucoma medication adherence among AA’s. Methods The nominal group technique (NGT), a highly structured focus group methodology, was implemented with 12 separate groups of AA’s patients with glaucoma (N = 89) to identify barriers and facilitators related to glaucoma medication usage. Participant rank-ordering votes were summed across groups and categorized into themes. Next, an individually and culturally targeted health promotion program promoting appropriate medication adherence was developed based on focus group results and input from a community-based participatory research team. Results The top five barriers included problems with 1) forgetfulness, 2) side effects, 3) cost/affordability, 4) eye drop administration, and 5) the eye drop schedule. The most salient top five facilitators were 1) fear or thoughts about the consequences of not taking eye drops, 2) use of memory aids, cues, or strategies, 3) maintaining a regular routine or schedule for eye drop administration, 4) ability to afford eye drops, and 5) keeping eye drops in the same area. The resulting health promotion program was based on a multi-component empowerment framework that included glaucoma education, motivational interviewing, and problem-solving training to improve glaucoma medication adherence. Conclusions Barriers and facilitators related to glaucoma medication adherence among AA’s are multifactorial. Based on the NGT themes and input from the community-based participatory research team, a culturally informed, health promotion program was designed and holds great promise for improving medication adherence among this vulnerable population. PMID:23873033

  3. Measuring Financial Literacy: Developing and Testing a Measurement Instrument with a Selected Group of South African Military Officers

    ERIC Educational Resources Information Center

    Schwella, E.; van Nieuwenhuyzen, Bernard J.

    2014-01-01

    Are South Africans financially literate, and how can this be measured? Until 2009 there was no South African financial literacy measure and, therefore, the aim was to develop a South African measurement instrument that is scientific, socially acceptable, valid and reliable. To achieve this aim a contextual and conceptual analysis of financial…

  4. Development of Auxiliaries in Young Children Learning African American English

    ERIC Educational Resources Information Center

    Newkirk-Turner, Brandi L.; Oetting, Janna B.; Stockman, Ida J.

    2016-01-01

    Purpose: We examined language samples of young children learning African American English (AAE) to determine if and when their use of auxiliaries shows dialect-universal and dialect-specific effects. Method: The data were longitudinal language samples obtained from two children, ages 18 to 36 months, and three children, ages 33 to 51 months.…

  5. [Coupling coordinated development of ecological-economic system in Loess Plateau].

    PubMed

    Zhang, Qing-Feng; Wu, Fa-Qi; Wang, Li; Wang, Jian

    2011-06-01

    Based on system theory, a coupling coordinated development model of ecological-economic system in Loess Plateau was established, and the evaluation criteria and basic types of the coordinated development of the ecological-economic system were proposed. The county-level coupling coordinated development of the ecological-economic system was also discussed, based on the local characteristics. The interactions between the ecological and economic systems in Loess Plateau could be divided into four stages, i.e., seriously disordered development stage, mild-disordered development stage, low-level coordinated development stage, and high level well-coordinated development stage. At each stage, there existed a cyclic process of profit and loss-antagonist-running-dominant-synchronous development. The coupling development degree of the ecological-economic system in Loess Plateau was overall at a lower level, being about 62.7% of the counties at serious disorder, 30.1% of the counties at mild disorder, and 7.1% of the counties at low but coordinated level. The coupling development degree based on the model established in this study could better reflect the current social-economic and ecological environment situations, especially the status of coordination. To fully understand the coupling of ecological-economic system and to adopt appropriate development mode would be of significance to promote the county-level coordinated development in Loess Plateau.

  6. The Development of Categorical and Coordinate Spatial Relations

    ERIC Educational Resources Information Center

    Bullens, Jessue; Postma, Albert

    2008-01-01

    Two classes of spatial relations can be distinguished in between and within object representations. Kosslyn [Kosslyn, S. M. (1987). "Seeing and imagining in the cerebral hemispheres: A computational approach." "Psychological Review," 94, 148-175] suggested that the right hemisphere (RH) is specialized for processing coordinate (metric) spatial…

  7. Anxiety psychopathology in African American adults: literature review and development of an empirically informed sociocultural model.

    PubMed

    Hunter, Lora Rose; Schmidt, Norman B

    2010-03-01

    In this review, the extant literature concerning anxiety psychopathology in African American adults is summarized to develop a testable, explanatory framework with implications for future research. The model was designed to account for purported lower rates of anxiety disorders in African Americans compared to European Americans, along with other ethnoracial differences reported in the literature. Three specific beliefs or attitudes related to the sociocultural experience of African Americans are identified: awareness of racism, stigma of mental illness, and salience of physical illnesses. In our model, we propose that these psychological processes influence interpretations and behaviors relevant to the expression of nonpathological anxiety as well as features of diagnosable anxiety conditions. Moreover, differences in these processes may explain the differential assessed rates of anxiety disorders in African Americans. The model is discussed in the context of existing models of anxiety etiology. Specific follow-up research is also suggested, along with implications for clinical assessment, diagnosis, and treatment.

  8. The impact of HIV/AIDS on human development in African countries

    PubMed Central

    2009-01-01

    Background In the present paper, we consider the impact of HIV/AIDS on human development in African countries, showing that, beyond health issues, this disease should and must be seen as a global development concern, affecting all components of human development. Consequently, we stress the necessity of multidisciplinary approaches that model, estimate and predict the real impact of HIV/AIDS on human development of African countries in order to optimise the strategies proposed by national countries, international institutions and their partners. Methods In our search strategy, we relied on secondary information, mainly through National Human Development Reports of some African countries and regular publications released by the United Nations (UN), United Nations Development Programme (UNDP), World Health Organization (WHO) and the World Bank. We restricted ourselves to reports dealing explicitly with the impact of HIV/AIDS on human development in African countries. Results and discussion HIV/AIDS is affecting the global human development of African countries through its devastating impact on health and demographic indicators such as life expectancy at birth, healthcare assistance, age and sex distribution, economic indicators like income, work force, and economic growth, education and knowledge acquisition and other indicators like governance, gender inequality and human rights. Conclusion On the basis of the national reports reviewed, it appears clearly that HIV/AIDS is no longer a crisis only for the healthcare sector, but presents a challenge to all sectors. Consequently, HIV/AIDS is a development question and should be viewed as such. The disease is impeding development by imposing a steady decline in the key indicators of human development and hence reversing the social and economic gains that African countries are striving to attain. Being at the same time a cause and consequence of poverty and underdevelopment, it constitutes a challenge to human security

  9. The Development of Motor Coordination in Drosophila Embryos

    PubMed Central

    Crisp, Sarah; Evers, Jan Felix; Fiala, André; Bate, Michael

    2012-01-01

    We use non-invasive muscle imaging to study onset of motor activity and emergence of coordinated movement in Drosophila embryos. Earliest movements are myogenic and neurally controlled muscle contractions first appear with the onset of bursting activity 17 hours after egg laying. Initial episodes of activity are poorly organised and coordinated crawling sequences only begin to appear after a further hour of bursting. Thus network performance improves during this first period of activity. The embryo continues to exhibit bursts of crawling like sequences until shortly before hatching, while other reflexes also mature. Bursting does not begin as a reflex response to sensory input but appears to reflect the onset of spontaneous activity in the motor network. It does not require GABA-ergic transmission, and using a light activated channel to excite the network we demonstrate activity dependent depression that may cause burst termination. PMID:18927150

  10. Coordinating Social-Emotional and Character Development (SECD) Initiatives Improves School Climate and Student Learning

    ERIC Educational Resources Information Center

    Elias, Maurice J.; DeFini, Jennifer; Bergmann, Jennifer

    2010-01-01

    Many schools attempt to implement multiple programs to promote positive young adolescent development; however, these programs are often fragmented and lack coordination. The authors describe an initiative designed to help schools coordinate their social-emotional and character development (SECD) efforts to improve school climate and help students…

  11. 15 CFR 930.153 - Coordination between States in developing coastal management policies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Coordination between States in developing coastal management policies. Coastal States are encouraged to give... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Coordination between States in developing coastal management policies. 930.153 Section 930.153 Commerce and Foreign Trade...

  12. How Can Agile Practices Minimize Global Software Development Co-ordination Risks?

    NASA Astrophysics Data System (ADS)

    Hossain, Emam; Babar, Muhammad Ali; Verner, June

    The distribution of project stakeholders in Global Software Development (GSD) projects provides significant risks related to project communication, coordination and control processes. There is growing interest in applying agile practices in GSD projects in order to leverage the advantages of both approaches. In some cases, GSD project managers use agile practices to reduce project distribution challenges. We use an existing coordination framework to identify GSD coordination problems due to temporal, geographical and socio-cultural distances. An industry-based case study is used to describe, explore and explain the use of agile practices to reduce development coordination challenges.

  13. Developing culturally competent marriage and family therapists: treatment guidelines for non-African-American therapists working with African-American families.

    PubMed

    Bean, Roy A; Perry, Benjamin J; Bedell, Tina M

    2002-04-01

    To serve African-American families effectively, marriage and family therapists need to develop a level of cultural competence. This content analysis of the relevant treatment literature was conducted to examine the most common expert recommendations for family therapy with African Americans. Fifteen specific guidelines were generated, including orient the family to therapy, do not assume familiarity, address issue of racism, intervene multi-systemically, do home visits, use problem-solving focus, involve religious leader, incorporate the father, and acknowledge strengths. Conceptual and empirical support for each guideline is discussed, and conclusions are made regarding culturally competent therapy with African-American families.

  14. Parental Factors that Influence the Career Development of College-Bound African American High School Seniors

    ERIC Educational Resources Information Center

    Bostic, Shenice S.

    2010-01-01

    Parents have been identified as being the most influential factor upon their children career development. There are various factors that influence the career development of individuals from different ethnic backgrounds. The purpose of the study was to identify parental factors that influence the career development of college-bound African American…

  15. Capacity development for health research in Africa: experiences managing the African Doctoral Dissertation Research Fellowship Program

    PubMed Central

    2010-01-01

    Africa's progress depends on her capacity to generate, adapt, and use scientific knowledge to meet regional health and development needs. Yet, Africa's higher education institutions that are mandated to foster this capacity lack adequate resources to generate and apply knowledge, raising the need for innovative approaches to enhance research capacity. In this paper, we describe a newly-developed program to support PhD research in health and population sciences at African universities, the African Doctoral Dissertation Research Fellowship (ADDRF) Program. We also share our experiences implementing the program. As health research capacity-strengthening in Africa continues to attract attention and as the need for such programs to be African-led is emphasized, our experiences in developing and implementing the ADDRF offer invaluable lessons to other institutions undertaking similar initiatives. PMID:20587016

  16. A Developing Framework for the Development, Implementation and Maintenance of HIV Interventions in the African American Church

    PubMed Central

    Stewart, Jennifer M.

    2016-01-01

    The African American church has promoted the health of African Americans through supporting interventions that target a wide variety of diseases, and it is a crucial community partner in the development of HIV prevention interventions. Although research has described the development of church-based HIV interventions, there is a significant lack of frameworks and approaches available to guide the implementation and maintenance of HIV interventions within church-based settings. A developing framework of a comprehensive church-based intervention, derived from an ethnographic study about the development, implementation, and maintenance of an HIV/AIDS Ministry within an African American church is presented. This approach can provide guidance to support the development, implementation, and maintenance of HIV interventions in faith settings. PMID:25702738

  17. Changes in Interhemispheric Transfer Rate and the Development of Bimanual Coordination during Childhood.

    ERIC Educational Resources Information Center

    Fagard, Jacqueline; Hardy-Leger, Isabelle; Kervella, Claude; Marks, Anne

    2001-01-01

    Studied the effect of interhemispheric communication development on age-related changes in bimanual coordination. Findings indicated that improved interhemispheric communication contributes to progress in bimanual coordination, especially that which requires resisting the attraction of mirror movements in order to rotate both hands with parallel…

  18. 22 CFR 1508.615 - How does the African Development Foundation notify a person of a suspension or debarment action?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 2 2012-04-01 2009-04-01 true How does the African Development Foundation... DEVELOPMENT FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General Principles Relating to Suspension and Debarment Actions § 1508.615 How does the African Development Foundation notify a person of...

  19. 22 CFR 1508.615 - How does the African Development Foundation notify a person of a suspension or debarment action?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true How does the African Development Foundation... DEVELOPMENT FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General Principles Relating to Suspension and Debarment Actions § 1508.615 How does the African Development Foundation notify a person of...

  20. 22 CFR 1508.615 - How does the African Development Foundation notify a person of a suspension or debarment action?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 2 2014-04-01 2014-04-01 false How does the African Development Foundation... DEVELOPMENT FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General Principles Relating to Suspension and Debarment Actions § 1508.615 How does the African Development Foundation notify a person of...

  1. 22 CFR 1508.615 - How does the African Development Foundation notify a person of a suspension or debarment action?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 2 2011-04-01 2009-04-01 true How does the African Development Foundation... DEVELOPMENT FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General Principles Relating to Suspension and Debarment Actions § 1508.615 How does the African Development Foundation notify a person of...

  2. 22 CFR 1508.615 - How does the African Development Foundation notify a person of a suspension or debarment action?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 2 2013-04-01 2009-04-01 true How does the African Development Foundation... DEVELOPMENT FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General Principles Relating to Suspension and Debarment Actions § 1508.615 How does the African Development Foundation notify a person of...

  3. FET College Lecturers: The "Devolving" Link in the South African Skills Development Equation

    ERIC Educational Resources Information Center

    Akoojee, Salim

    2008-01-01

    National attention on the role of skills development has focused on the role of Further Education and Training (FET) colleges in providing intermediate-level education and training necessary to meet the South African national development challenge. In particular, attention has been focused on reorganisation and rationalisation of college…

  4. Development and validation of measures of religious involvement and the cancer experience among African Americans

    PubMed Central

    Holt, Cheryl L.; Caplan, Lee; Schulz, Emily; Blake, Victor; Southward, Vivian L.; Buckner, Ayanna V.

    2013-01-01

    Research indicates that African Americans diagnosed with cancer tend to use religion in coping, however less is known about the specific role that religion plays in the coping process. Based on previous qualitative work, five instruments were developed to assess the role of religious involvement in cancer coping: God as helper, God as healer, Faith in healing, Control over cancer, and New perspective. The instruments were administered to 100 African Americans with cancer. Each exhibited high internal reliability, and concurrent and discriminant validity. These instruments may have applied value for the development of church-based cancer support/survivorship interventions. PMID:19383653

  5. The role of small satellites in the development of the South African space programme

    NASA Astrophysics Data System (ADS)

    Martinez, Peter

    In the 1990s a team of scientists and engineers at Stellenbosch University built the first South African satellite to fly in space, the 64-kg Sunsat. This university-based satellite programme took advantage of the skills and facilities developed in the previous South African space programme of the 1980s and early 1990s, which had developed a much larger satellite (Greensat), but was cancelled in the mid-1990s prior to launch. Sunsat incorporated a number of novel capabilities for a microsatellite platform, and interest was shown in these technologies by other groups developing similar satellites. As the University was not the ideal environment to develop the commercial potential of these microsatellite technologies, a company called Sunspace was later established, thus creating industrial capacity in South Africa in a niche area of space technology. This new industrial capability, together with the infrastructure from the previous space programme, have created a foundation upon which to build the new South African space programme. This paper discusses the historical, current and possible future roles of small satellites in the development of the South African space programme.

  6. The Impact of Racial Identity and Consciousness Development of African American Male Academic Achievement: Implications for Counseling

    ERIC Educational Resources Information Center

    Whiteside, Dora

    2007-01-01

    The purpose of this study was to examine the effect of racial identity/consciousness development on the academic achievement of African American male college freshmen. In the late 1900s Black identity models were developed to help African Americans grasp hold of who they were, as they lived in the residues of the peculiar institution of slavery.…

  7. 22 CFR 1508.630 - May the African Development Foundation impute conduct of one person to another?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 2 2014-04-01 2014-04-01 false May the African Development Foundation impute... FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General Principles Relating to Suspension and Debarment Actions § 1508.630 May the African Development Foundation impute conduct of one...

  8. 22 CFR 1508.610 - What procedures does the African Development Foundation use in suspension and debarment actions?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Foundation use in suspension and debarment actions? 1508.610 Section 1508.610 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General Principles Relating to Suspension and Debarment Actions § 1508.610 What procedures does the African Development Foundation use...

  9. 22 CFR 1508.610 - What procedures does the African Development Foundation use in suspension and debarment actions?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Foundation use in suspension and debarment actions? 1508.610 Section 1508.610 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General Principles Relating to Suspension and Debarment Actions § 1508.610 What procedures does the African Development Foundation use...

  10. 22 CFR 1508.610 - What procedures does the African Development Foundation use in suspension and debarment actions?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Foundation use in suspension and debarment actions? 1508.610 Section 1508.610 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General Principles Relating to Suspension and Debarment Actions § 1508.610 What procedures does the African Development Foundation use...

  11. 22 CFR 1508.630 - May the African Development Foundation impute conduct of one person to another?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 2 2011-04-01 2009-04-01 true May the African Development Foundation impute... FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General Principles Relating to Suspension and Debarment Actions § 1508.630 May the African Development Foundation impute conduct of one...

  12. 22 CFR 1508.630 - May the African Development Foundation impute conduct of one person to another?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true May the African Development Foundation impute... FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General Principles Relating to Suspension and Debarment Actions § 1508.630 May the African Development Foundation impute conduct of one...

  13. 22 CFR 1508.630 - May the African Development Foundation impute conduct of one person to another?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 2 2012-04-01 2009-04-01 true May the African Development Foundation impute... FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General Principles Relating to Suspension and Debarment Actions § 1508.630 May the African Development Foundation impute conduct of one...

  14. 22 CFR 1508.610 - What procedures does the African Development Foundation use in suspension and debarment actions?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Foundation use in suspension and debarment actions? 1508.610 Section 1508.610 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General Principles Relating to Suspension and Debarment Actions § 1508.610 What procedures does the African Development Foundation use...

  15. 22 CFR 1508.610 - What procedures does the African Development Foundation use in suspension and debarment actions?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Foundation use in suspension and debarment actions? 1508.610 Section 1508.610 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General Principles Relating to Suspension and Debarment Actions § 1508.610 What procedures does the African Development Foundation use...

  16. 22 CFR 1508.630 - May the African Development Foundation impute conduct of one person to another?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 2 2013-04-01 2009-04-01 true May the African Development Foundation impute... FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General Principles Relating to Suspension and Debarment Actions § 1508.630 May the African Development Foundation impute conduct of one...

  17. International Development and Research Capacities: Increasing Access to African Scholarly Publishing

    ERIC Educational Resources Information Center

    Metcalfe, Amy Scott; Esseh, Samuel; Willinsky, John

    2009-01-01

    This paper examines the evolving relationship between Canada and the African academic research community through the promotion of a concept known as Information and Communication Technology for Development (ICT4D) and with an eye to its implications for increasing the circulation of research through such means as open access (OA) publishing…

  18. Problematising the Standardisation of Leadership and Management Development in South African Schools

    ERIC Educational Resources Information Center

    Williams, Clarence

    2015-01-01

    In 2007 the Department of Education introduced the standards-based Advanced Certificate in Education: School Management and Leadership. The standardisation of leadership and management development in South African schools has been uncritically accepted by most academics and professionals. The purpose of this article is to problematise the…

  19. Religion, Spirituality, and Career Development in African American College Students: A Qualitative Inquiry

    ERIC Educational Resources Information Center

    Constantine, Madonna G.; Miville, Marie L.; Warren, Anika K.; Gainor, Kathy A.; Lewis-Coles, Ma'at E. L.

    2006-01-01

    The authors explored through semistructured interviews the interrelationships of religion, spirituality, and career development in a sample of 12 African American undergraduate students. Using consensual qualitative research methodology (C. E. Hill, B. J. Thompson, & E. N. Williams, 1997), they identified 6 primary domains or themes related to…

  20. 3 CFR - Eligibility of the Southern African Development Community To Receive Defense Articles and Defense...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Amended, and the Arms Export Control Act, as Amended Memorandum for the Secretary of State Pursuant to the authority vested in me by the Constitution and the laws of the United States, including section 503(a) of... African Development Community will strengthen the security of the......

  1. Migration from Developing Countries: The Case of South African Teachers to the United Kingdom

    ERIC Educational Resources Information Center

    De Villiers, Rian

    2007-01-01

    The United Kingdom (particularly England) is the main developed country that recruits teachers from South Africa. This article provides an overview of teacher migration from South Africa to the United Kingdom over the past decade. The research focuses on the following aspects of migration: the recruitment of South African teachers; motivation for…

  2. The Features of Development in the Pacific Countries of the African, Caribbean and Pacific Group

    ERIC Educational Resources Information Center

    Cuenca Garcia, Eduardo; Rodriguez Martin, Jose Antonio; Navarro Pabsdorf, Margarita

    2010-01-01

    In this article we present a new proposal for the measurement of development, applied to the Pacific Countries of the African, Caribbean and Pacific Group (ACP), conditional on their insularity, and with privileged relations with the European Union. Our index has been constructed attending to the criteria defined in the Goals of the Millennium…

  3. African American Family Life: Ecological and Cultural Diversity. Duke Series in Child Development and Public Policy

    ERIC Educational Resources Information Center

    McLoyd, Vonnie C., Ed.; Hill, Nancy E., Ed.; Dodge, Kenneth A., Ed.

    2005-01-01

    This volume brings together leading experts from different disciplines to offer new perspectives on contemporary African American families. A wealth of knowledge is presented on the heterogeneity of Black family life today; the challenges and opportunities facing parents, children, and communities; and the impact on health and development of key…

  4. A Phenomenological Study on the Leadership Development of African American Women Executives in Academia and Business

    ERIC Educational Resources Information Center

    Davis, Deanna Rachelle

    2012-01-01

    The purpose of this qualitative phenomenological study was to explore the intersectionality of race and gender for African American women through their lived experiences of how they developed into leaders. This research study was designed to determine how the intersection of race and gender identities contributed to the elements of leadership…

  5. Developing a Cancer Prevention Programme for African-American Daughters and Mothers

    ERIC Educational Resources Information Center

    Annang, Lucy; Spencer, S. Melinda; Jackson, Dawnyéa; Rosemond, Tiara N.; Best, Alicia L.; Williams, Leah R.; Carlos, Bethany

    2015-01-01

    Objective: To describe how nominal group technique was used to inform the development of a breast and cervical cancer awareness programme for African-American adult daughters and mothers. Design: A qualitative approach using nominal group technique. Setting: A mid-sized city in the Southern USA. Method: Nominal group technique was used with 30…

  6. Development and Validation of the Adolescent Racial and Ethnic Socialization Scale (ARESS) in African American Families

    ERIC Educational Resources Information Center

    Brown, Tiffany L.; Krishnakumar, Ambika

    2007-01-01

    Racial and ethnic socialization are an integral part of African American parenting strategies. Varied conceptualizations and operationalizations of racial and ethnic socialization exist within the literature with limited evidence of the validity of existing measures. The purpose of this study is to develop a comprehensive definition of racial and…

  7. Variable Use of Features Associated with African American English by Typically Developing Children

    ERIC Educational Resources Information Center

    Jackson, Janice E.; Pearson, Barbara Zurer

    2010-01-01

    Purpose: The well-known decline in the use of African American English (AAE) features by groups of school-aged AAE-speaking children was reexamined for patterns of overt-, zero-, and mixed-marking for individual features and individual speakers. Methods: Seven hundred twenty-nine typically developing children between the ages of 4 and 12--511…

  8. Lessons learned in developing a culturally adapted intervention for African-American families coping with parental cancer.

    PubMed

    Davey, Maureen P; Kissil, Karni; Lynch, Laura; Harmon, La-Rhonda; Hodgson, Nancy

    2012-12-01

    Prior clinical research supports the effectiveness of cancer support groups for cancer patients and their families, yet African-American families continue to be underrepresented in cancer support groups and in cancer clinical research studies. In order to fill this gap, we developed and evaluated a culturally adapted family support group for African-American families coping with parental cancer. We encountered unexpected challenges in overcoming barriers to recruitment, partnering with oncology providers, and building trust with the African-American community and African-American families coping with parental cancer. We describe actions taken during the two phases of this study and lessons learned along the way about recruiting and engaging African-American families in cancer support group studies, partnering with oncology providers, networking with the African-American community, and the importance of demonstrating cultural sensitivity to overcome the understandable historical legacy of mistrust.

  9. DEVELOPMENT OF MULTI-COORDINATE VOCABULARY, PLASMA PHYSICS.

    ERIC Educational Resources Information Center

    LERNER, RITA G.

    DESCRIBED IS THE DEVELOPMENT OF A THESAURUS FOR THE FIELD OF PLASMA PHYSICS, SIMILAR TO THE ONE PREVIOUSLY DEVELOPED FOR CHEMICAL PHYSICS, FOR USE WITH COMPUTER-ORIENTED RETRIEVAL SYSTEMS. AN EXPERT IN THE FIELD OF PLASMA PHYSICS SELECTED TERMS IMPORTANT TO THE INFORMATION USER FROM THE PLASMA LITERATURE. THE HIERARCHY OF CLASSIFICATION UTILIZES…

  10. The Development of Coordinated Communication in Infants at Heightened Risk for Autism Spectrum Disorder

    PubMed Central

    Parladé, Meaghan V.; Iverson, Jana M.

    2015-01-01

    This study evaluated the extent to which developmental change in coordination of social communication in early infancy differentiates children eventually diagnosed with ASD from those not likely to develop the disorder. A prospective longitudinal design was used to compare 9 infants at heightened risk for ASD (HR) later diagnosed with ASD, to 13 HR infants with language delay, 28 HR infants with no diagnosis, and 30 low risk infants. Hierarchical Linear Modeling (HLM) analyses revealed that ASD infants exhibited significantly slower growth in coordinations overall and in gestures coordinated with vocalizations, even relative to HR infants with language delay. Disruption in the development of gesture-vocalization coordinations may result in negative cascading effects that negatively impact later social and linguistic development. PMID:25689930

  11. Coordinating Low Emission Development in Columbia (Fact Sheet)

    SciTech Connect

    Watson, A.; Butheau, M.; Sandor, D.

    2013-11-01

    Colombia's economy has grown more than 4 percent per year for a decade, but climate change is posing new risks to sustaining that development. With the nation's coastal areas, mountain ranges, rain forests, plains, and river basins vulnerable to changing weather patterns and growing seasons, Colombia is building resilience to climate change while working to curb emissions and pursue new options for low emission development.

  12. Design and production of an atlas for diplomacy in Zimbabwe and the Southern African Development Community

    USGS Publications Warehouse

    Crawford, T.W.; Larson, C.R.; Granneman, B.J.; Evans, G.A.; Gacke, C.K.; Pearson, D.R.

    1999-01-01

    An atlas of Zimbabwe and the Southern African Development Community was designed and produced for use by American diplomats in Zimbabwe. Two copies of the bound atlas are used by the Embassy of the United States of America (U.S. Embassy) and the Mission of the U.S. Agency for International Development (USAID) in Harare, Zimbabwe, to orient visitors and discuss matters of diplomacy and development in Zimbabwe and the Southern African Development Community. The atlas contains maps derived from satellite images showing features of the physical geography of Southern Africa and Zimbabwe and plastic overlays showing rivers and lakes and manmade features, such as major roads, railroads, and cities. The atlas is an important tool that American diplomats can use to orient participants in discussions of the environment and to develop agreements for management of the environment in Zimbabwe and Southern Africa.

  13. Developing spiritually framed breast cancer screening messages in consultation with African American women.

    PubMed

    Best, Alicia L; Spencer, Mindi; Hall, Ingrid J; Friedman, Daniela B; Billings, Deborah

    2015-01-01

    Despite efforts to increase breast cancer screening (BCS) among African American women, disparities in breast cancer mortality persist. Culturally framed health communication may provide a useful strategy to address this issue. Spirituality not only represents an integral aspect of African American culture, but it has also been identified as a potential barrier to BCS among this population. Rather than continuing to focus on spirituality as a barrier, there is an opportunity to develop promotional messages that tap into the protective properties of spirituality among this population. The goals of this study were to engage a group of African American women to identify important spiritual elements to be included in health communication materials, and to subsequently develop a spiritually framed BCS message in response to their feedback. Three nominal group sessions were conducted with 15 African American women. Results revealed three important spiritual elements that can be incorporated into BCS health messages: (a) the body as a temple; (b) going to the doctor does not make you faithless; and (c) God did not give us the spirit of fear. These elements were used to draft a spiritually framed BCS message. Next, 20 face-to-face semistructured interviews were conducted to help finalize the spiritually framed BCS message for use in a future study on culturally framed health communication.

  14. Developing spiritually framed breast cancer screening messages in consultation with African American women.

    PubMed

    Best, Alicia L; Spencer, Mindi; Hall, Ingrid J; Friedman, Daniela B; Billings, Deborah

    2015-01-01

    Despite efforts to increase breast cancer screening (BCS) among African American women, disparities in breast cancer mortality persist. Culturally framed health communication may provide a useful strategy to address this issue. Spirituality not only represents an integral aspect of African American culture, but it has also been identified as a potential barrier to BCS among this population. Rather than continuing to focus on spirituality as a barrier, there is an opportunity to develop promotional messages that tap into the protective properties of spirituality among this population. The goals of this study were to engage a group of African American women to identify important spiritual elements to be included in health communication materials, and to subsequently develop a spiritually framed BCS message in response to their feedback. Three nominal group sessions were conducted with 15 African American women. Results revealed three important spiritual elements that can be incorporated into BCS health messages: (a) the body as a temple; (b) going to the doctor does not make you faithless; and (c) God did not give us the spirit of fear. These elements were used to draft a spiritually framed BCS message. Next, 20 face-to-face semistructured interviews were conducted to help finalize the spiritually framed BCS message for use in a future study on culturally framed health communication. PMID:24837069

  15. Poverty and the Development of African American Children: Testing an Adaptation of McLoyd's Theoretical Model with the NLSY.

    ERIC Educational Resources Information Center

    Nievar, M. Angela; Luster, Tom

    Based on McLoyd's (1990) model of African American children's development, this study examined the linkages between poverty, maternal psychological distress, marital conflict, the home environment, and children's outcomes among a sample of 805 African American 4- to 9-year-olds whose families were interviewed in 1992 as part of the National…

  16. Learning Other People's History: Pre-Service Teachers' Developing African American Historical Knowledge

    ERIC Educational Resources Information Center

    King, LaGarrett Jarriel

    2014-01-01

    Drawing from the historical lens of cultural memory, I examined the development of three social studies pre-service teachers' African American history knowledge. The participants were engaged in a rigorous summer reading program dedicated to learning African American history. This qualitative case study examined both pre and post…

  17. Education for Democracy: Using the Classroom Community of Inquiry to Develop Habits of Reflective Judgement in South African Schools

    ERIC Educational Resources Information Center

    Green, Lena

    2009-01-01

    This paper reports on an initiative to introduce, not the Philosophy for Children (P4C) programme itself, but its principles and some of its practices, into South African schools. The paper points out the conceptual links between P4C and the understanding of human development that underpins the new South African curriculum, and provides a brief…

  18. Primary Science Curriculum Development in Africa--Strategies, Problems and Prospects with Particular Reference to the African Primary Science Programme.

    ERIC Educational Resources Information Center

    Bajah, Sam Tunde

    1981-01-01

    The African Primary Science Programme (APSP) was one of the three major projects in Africa sponsored by Educational Services Incorporated (ESI), later the Educational Development Center (EDC), Newton, Massachusetts. The problems of introducing this programme in the anglophone African States and its implications for science education are discussed.…

  19. African Regional Seminar for Advanced Training In Systematic Curriculum Development and Evaluation. (Achimota, Ghana, 14 July--15 August 1975). Report.

    ERIC Educational Resources Information Center

    Swedish International Development Authority (SIDA).

    This report summarizes the African Regional Seminar for Advanced Training in Systematic Curriculum Development and Evaluation that was held at Achimota, Ghana, July 14-August 15 1975. Attending the seminar were 67 participants from 12 African countries, including Cameroon, Gambia, Ghana, Kenya, Liberia, Malawi, Nigeria, Sierra Leone, Swaziland,…

  20. DEVELOPMENT OF A MULTI-COORDINATE VOCABULARY, CHEMICAL PHYSICS.

    ERIC Educational Resources Information Center

    LERNER, RITA G.

    THIS PAPER DESCRIBES A METHOD (SCHEME) FOR THE DEVELOPMENT OF A VOCABULARY IN THE FIELD OF CHEMICAL PHYSICS FROM PRIMARY JOURNAL ARTICLES. ALL TERMS APPEARING IN A RECENT JOURNAL (VOL. 39, JOURNAL OF CHEMICAL PHYSICS) JUDGED TO BE IMPORTANT WERE DIVIDED INTO THREE CATEGORIES--(1) PROPERTIES, PROCESSES, PHENOMENA, (2) OBJECTS, INCLUDING SYSTEMS AND…

  1. A Coordinated Decentralized Approach to Online Project Development

    ERIC Educational Resources Information Center

    Mykota, David

    2013-01-01

    With the growth rate of online learning outpacing traditional face-to-face instruction, universities are beginning to recognize the importance of strategic planning in its development. Making the case for online learning requires sound project management practices and an understanding of the business models on which it is predicated. The objective…

  2. Positive youth development among African American adolescents: examining single parents as a factor.

    PubMed

    Roberts, Shani R; Lewis, Rhonda K; Carmack, Chakema

    2011-01-01

    Over the past few decades researchers have begun to examine the importance of understanding positive youth development and the many contexts in which youth find themselves. The social contexts in which adolescent development occurs are varied and complex, particularly the development among African American youth. African American youth are faced with a number of challenges including living in single-parent homes, high teen pregnancy rates, and poor neighborhoods, yet many of these youth continue to thrive. The purpose of this study was to examine the relationship between family structure (single-parenting) and adolescent outcomes such as educational aspirations and sexual activity among African American adolescent youth aged 12-17. Approximately 462 African American youth were surveyed. A number of positive results emerged; for instance, there was a negative correlation between family structure and educational aspirations. The number of parents in the home did not interfere with youth wanting to complete high school and go on to college (r = - .218, r² = .04, p < .05). The results also showed that as educational aspirations increased, the number of sexual partners decreased (r = - .141, meaning that the more adolescents reported a desire to complete high school, they were less likely to report having sexual intercourse. These positive results should be promoted among African American youth so that those faced with these challenges will note that others have overcome and accomplished their goals. In this population educational aspirations were important. Limitations and future research are discussed. PMID:21992021

  3. Fatherhood Intervention Development in Collaboration with African American Non-resident Fathers

    PubMed Central

    Julion, Wrenetha A.; Breitenstein, Susan M.; Waddell, Donald

    2012-01-01

    Because interventions developed in partnership with African American fathers not residing with their children are virtually non-existent, existing interventions fail to address the multiple factors that constrain these fathers’ positive involvement with their children. We developed a video tape fatherhood intervention: Building Bridges to Fatherhood. In collaboration with a Fathers Advisory Council composed of 12 African American fathers, we used Aranda’s framework for community-based nursing intervention development to design the intervention. Data from 13 focus group meetings show Advisory Council members’ insights on program structure and content, fathers’ commitment to their children and communities, and the benefits they garnered from Council participation. The implications for involving fathers in intervention development include using relevant language, vernacular, and interpersonal interactions. PMID:22685066

  4. Perceptions of Course Coordinators and Course Writers for Developing Distance Learning Material

    ERIC Educational Resources Information Center

    Imran Yousuf, Muhammad; Anwar, Muhammad Nadeem; Sarwar, Muhammad

    2008-01-01

    The main aim of this research is to better understand and draw perceptions of course writers and course coordinators towards the process of developing distance learning material. For developing good self-instructional material cooperative efforts among course development personnel are essential. The study indicates the areas where contradiction is…

  5. Development and Validation of the Body Size Scale for Assessing Body Weight Perception in African Populations

    PubMed Central

    Cohen, Emmanuel; Bernard, Jonathan Y.; Ponty, Amandine; Ndao, Amadou; Amougou, Norbert; Saïd-Mohamed, Rihlat; Pasquet, Patrick

    2015-01-01

    Background The social valorisation of overweight in African populations could promote high-risk eating behaviours and therefore become a risk factor of obesity. However, existing scales to assess body image are usually not accurate enough to allow comparative studies of body weight perception in different African populations. This study aimed to develop and validate the Body Size Scale (BSS) to estimate African body weight perception. Methods Anthropometric measures of 80 Cameroonians and 81 Senegalese were used to evaluate three criteria of adiposity: body mass index (BMI), overall percentage of fat, and endomorphy (fat component of the somatotype). To develop the BSS, the participants were photographed in full face and profile positions. Models were selected for their representativeness of the wide variability in adiposity with a progressive increase along the scale. Then, for the validation protocol, participants self-administered the BSS to assess self-perceived current body size (CBS), desired body size (DBS) and provide a “body self-satisfaction index.” This protocol included construct validity, test-retest reliability and convergent validity and was carried out with three independent samples of respectively 201, 103 and 1115 Cameroonians. Results The BSS comprises two sex-specific scales of photos of 9 models each, and ordered by increasing adiposity. Most participants were able to correctly order the BSS by increasing adiposity, using three different words to define body size. Test-retest reliability was consistent in estimating CBS, DBS and the “body self-satisfaction index.” The CBS was highly correlated to the objective BMI, and two different indexes assessed with the BSS were consistent with declarations obtained in interviews. Conclusion The BSS is the first scale with photos of real African models taken in both full face and profile and representing a wide and representative variability in adiposity. The validation protocol proved its

  6. Understanding the findings of resilience-related research for fostering the development of African American adolescents.

    PubMed

    Barrow, Frederica H; Armstrong, Mary I; Vargo, Amy; Boothroyd, Roger A

    2007-04-01

    African American youth face a number of challenges to prosocial development that the majority of American youth never encounter. Despite this, the research clearly documents that African American youth often are resilient in the face of these challenges. This article explores various factors associated with resilience in African American children and their implications for practitioners. An ecologic framework described by Bronfenbrenner is used as an organizing framework for understanding interventions at the micro-, mezzo-, and exo-system levels. In this article, the importance of identity formation, maintenance of social networks, and exposure to safe and supportive environments is expressed in conjunction with recommendations for practitioners. Practitioners are encouraged to stress the promotion of ethnic and racial identity and self-efficacy with the youth and their family and the involvement of the youth and family in meaningful activities through local community centers, schools, churches, and other organizations serving youth. A case study of an African American girl, from age 16 into adulthood and motherhood, is presented to illustrate the interplay between protective and risk factors.

  7. Topographic development in the late Neogene and the impact on African vegetation

    NASA Astrophysics Data System (ADS)

    Jung, Gerlinde; Prange, Matthias; Schulz, Michael

    2014-05-01

    Hominid evolution, specifically the split of the hominid-chimpansee lineages in the late Miocene has long been hypothesized to be linked to the retreat of the tropical rainforest in Africa in the late Miocene. A main cause for the climatic and vegetation change often considered was uplift of Africa but also uplift of the Himalaya and the Tibetan Plateau was suggested to have contributed to an intensification of the African-Asian monsoon system and hence impacted rainfall distribution over Eastern Africa. In contrast, more recent proxy data suggest that open grassland habitats were available to human ancestors and apes long before their divergence and that there is no evidence for a closed rainforest in the late Miocene. We use the coupled global circulation model CCSM3 with an online coupled dynamic vegetation module to investigate the impact of the uplift processes on the African-Asian monsoon circulation and consequent changes in tropical African vegetation. The model is run with a resolution of T85 (~1.4°) for the atmosphere and land surface and a variable resolution for the computation of ocean and sea ice down to a meridional grid spacing of 0.3° around the equator. We performed a set of sensitivity experiments, altering elevations of the Himalaya and the Tibet Plateau and of East and South Africa separately and in combination from half to full present day level. The simulations confirm the dominant impact of the East and South African uplift for climate and vegetation development of the African tropics. Only a weak, but significant, impact of the prescribed Asian Uplift on African monsoon and vegetation development could be detected. Himalaya/Tibet Plateau uplift lead to slightly dryer conditions in Central Africa and small increases in rainfall over East Africa. According to the model simulations topographic uplift of Africa significantly altered rainfall in Central Africa, which coincides with proxy records from the Congo basin showing a change towards

  8. African policy linking education and development: Standard criticisms and a new departure

    NASA Astrophysics Data System (ADS)

    Krieger, Milton

    1988-09-01

    Two generations of effort (from the 1920s to the 1960s) by pioneer African nationalists to use schools as the chief catalyst for national development strategy was followed by a generation of scholarship (from the 1960s to the 1980s) that was massively sceptical of their assumptions linking education, causally and positively, to development. The pioneers' writings and experiments, especially in southern Nigeria, are recounted in this paper's first section. The second section surveys the critical literature which experience, on the whole, justifies. The third and concluding section identifies a tangent of analysis which, it is argued, shifts the ground of the debate and supports more hopeful prospects for the current African generation's effort to link education and development productively. Evidence and comment are drawn principally from Anglophone West Africa, but there are inferences clearly to be drawn for general circumstances south of the Sahara.

  9. Coordination of Endoplasmic Reticulum (ER) Signaling During Maize Seed Development

    SciTech Connect

    Boston, Rebecca S.

    2010-11-20

    Seed storage reserves represent one of the most important sources of renewable fixed carbon and nitrogen found in nature. Seeds are well-adapted for diverting metabolic resources to synthesize storage proteins as well as enzymes and structural proteins needed for their transport and packaging into membrane bound storage protein bodies. Our underlying hypothesis is that the endoplasmic reticulum (ER) stress response provides the critical cellular control of metabolic flux required for optimal accumulation of storage reserves in seeds. This highly conserved response is a cellular mechanism to monitor the protein folding environment of the ER and restore homeostasis in the presence of unfolded or misfolded proteins. In seeds, deposition of storage proteins in protein bodies is a highly specialized process that takes place even in the presence of mutant proteins that no longer fold and package properly. The capacity of the ER to deposit these aberrant proteins in protein bodies during a period that extends several weeks provides an excellent model for deconvoluting the ER stress response of plants. We have focused in this project on the means by which the ER senses and responds to functional perturbations and the underlying intracellular communication that occurs among biosynthetic, trafficking and degradative pathways for proteins during seed development.

  10. Kit signaling is required for development of coordinated motility patterns in zebrafish gastrointestinal tract.

    PubMed

    Rich, Adam; Gordon, Scott; Brown, Chris; Gibbons, Simon J; Schaefer, Katherine; Hennig, Grant; Farrugia, Gianrico

    2013-06-01

    Interstitial cells of Cajal (ICC) provide a pacemaker signal for coordinated motility patterns in the mammalian gastrointestinal (GI) tract. Kit signaling is required for development and maintenance of ICC, and these cells can be identified by Kit-like immunoreactivity. The zebrafish GI tract has two distinct ICC networks similar to mammals, suggesting a similar role in the generation of GI motility; however, a functional role for Kit-positive cells in zebrafish has not been determined. Analysis of GI motility in intact zebrafish larvae was performed during development and after disruption of Kit signaling. Development of coordinated motility patterns occurred after 5 days post-fertilization (dpf) and correlated with appearance of Kit-positive cells. Disruptions of Kit signaling using the Kit antagonist imatinib mesylate, and in Sparse, a null kita mutant, also disrupted development of coordinated motility patterns. These data suggest that Kit signaling is necessary for development of coordinated motility patterns and that Kit-positive cells in zebrafish are necessary for coordinated motility patterns.

  11. Factors Contributing to the Development of an HIV Ministry within an African American Church

    PubMed Central

    Stewart, Jennifer M.; Dancy, Barbara L.

    2012-01-01

    Having an HIV ministry within a church depends on the religious culture of that church. However, little is known about how a church’s religious culture influences an HIV ministry. This study’s purpose was to examine how an African American church’s religious culture supported the development, implementation, and maintenance of an HIV ministry within the church. An ethnographic case study research design was used. Data were collected through interviews, non-participant and participant observations, review of pertinent documents, and survey of congregants. Results revealed the following as important for an HIV ministry: (a) a belief in helping others and treating everyone with respect and dignity, (b) feelings of compassion toward individuals infected with HIV, and (c) HIV education. This information can assist in developing interventions to enhance the African American church movement toward HIV ministries. PMID:22212914

  12. Development and characterization of microsatellite markers in the African deciduous tree Terminalia superba (Combretaceae)1

    PubMed Central

    Demenou, Boris B.; Migliore, Jérémy; Tosso, Felicien; Kaymak, Esra; Hardy, Olivier J.

    2015-01-01

    Premise of the study: Microsatellites were designed and characterized in the African timber forest tree Terminalia superba (Combretaceae). Due to their high variability, these markers are suitable to investigate gene flow patterns and the structure of genetic diversity. Methods and Results: From a genomic library obtained by next-generation sequencing, seven monomorphic and 14 polymorphic microsatellite loci were developed. The polymorphic microsatellites displayed two to 27 alleles (mean 11.4; expected heterozygosity range 0.283–0.940, mean 0.736) in one population from southeastern Cameroon. Genotypes were typical of an outbreeding diploid species, although null alleles explain a significant heterozygote deficit in three loci. Cross-amplification in three congeneric species (T. ivorensis, T. avicennioides, and T. mantaly) failed, suggesting that T. superba is rather divergent. Conclusions: This set of newly developed microsatellite markers will be useful for assessing the genetic diversity, population structure, and demographic history of T. superba in tropical African forests. PMID:26697276

  13. DEVELOPING A COORDINATED INFORMATION PROGRAM FOR GEOLOGICAL SCIENTISTS IN THE UNITED STATES.

    ERIC Educational Resources Information Center

    CREAGER, WILLIAM A.; SMITH, FOSTER D.

    A PLAN FOR THE DEVELOPMENT OF A COORDINATED INFORMATION PROGRAM FOR GEOLOGICAL SCIENTISTS IN THE UNITED STATES IS DISCUSSED IN DETAIL IN THIS REPORT. THE AMERICAN GEOLOGICAL INSTITUTE APPOINTED A COMMITTEE ON SCIENCE INFORMATION TO DEVELOP A NEW NETWORK FOR COMMUNICATION. THE NEED AROSE FROM A REALIZATION OF SEVERAL DEFICIENCIES OF PRESENT…

  14. Coordination of Organic Curriculum Development in the School District of Philadelphia, Pennsylvania. Final Report.

    ERIC Educational Resources Information Center

    Love, George H.

    This document describes the efforts of program administrators to implement an organic curriculum in a Philadelphia, Pennsylvania, high school. The chief program administrator coordinated the activities of eight advisory subcommittees, curriculum development personnel, staff development, and community relations. Organic curriculum is a learner-…

  15. The African Development Bank and women's health: a cross-national analysis of structural adjustment and maternal mortality.

    PubMed

    Coburn, Carolyn; Restivo, Michael; Shandra, John M

    2015-05-01

    We conduct a cross-national analysis to test the hypothesis that African Development Bank (AfDB) structural adjustment lending adversely impacts maternal mortality in Sub-Saharan Africa. We analyze data for thirty-five Sub-Saharan African nations with up to four time points (1990, 1995, 2000, and 2005) with generalized least squares random effects regression models and modified two-step Heckman models that correct for potential endogeneity regarding whether or not a Sub-Saharan African nations receives an AfDB structural adjustment loan. We find support for our hypothesis that indicates that Sub-Saharan African nations that receive an AfDB structural adjustment loan tend to have higher levels of maternal mortality than Sub-Saharan African nations that do not receive such a loan. This finding remains stable even when controlling for endogeneity. We conclude by talking about the theoretical and methodological implications along with possible directions for future research.

  16. Television for Development. The African Experience. IDRC Manuscript Report.

    ERIC Educational Resources Information Center

    McLellan, Iain

    Based on visits to and interviews in 14 countries (Senegal, The Gambia, Niger, Ivory Coast, Nigeria, Zaire, Congo, Zambia, Zimbabwe, Cameroon, the United States, France, Italy, and Canada) this report provides a detailed accounting of the present and potential use of television to support development through non-formal educational programming in…

  17. A Phenomenological Investigation on the Role of Mentoring in the Academic Development of African American Male Secondary Students

    NASA Astrophysics Data System (ADS)

    Inge, Jillian

    The purpose of this phenomenological study was to examine how the construct of mentoring by African American males can support the academic development of African American male students. Since African American male students perform significantly lower in academic subjects than their counterparts of other ethnicities, there is an exigent need for change in this area. Built upon the conceptual framework of communal interactions and identity, the inquiry questioned the experiences of mentors for African American male secondary students, and their perceptions of the influence of a mentoring relationship when the mentor and mentee are of similar backgrounds. Participants in this study were 7 African American males who had mentored or were currently mentoring African American male students. Data, obtained through semi structured interviews and focus group interviews, were coded for themes that reflected the experiences of mentors in mentoring African American males. Mentors in this study reported that students with whom they share similar backgrounds and experiences were better able to relate to them than those who had dissimilar backgrounds and experiences. In addition, mentors reported their mentees were more likely to envision themselves in professional areas beyond their perceived cultural norm when they routinely interact with successful African American males from various fields; thus, it was important for mentors to provide opportunities for students to interact with professionals. Contributions to social change will emerge as African American male mentors understand and employ their roles as a fundamental component in the academic development of African American male secondary students and thus empower this population of students to achieve academic success and to serve in a capacity that nurtures their immediate surroundings.

  18. A method to evaluate coordination between regional economic, social development and water resources

    NASA Astrophysics Data System (ADS)

    Zhou, S. B.; Qi, W. T.; Du, A. M.; He, H.

    2016-08-01

    Coordination between regional economic, social development and water resources is the key factor for the sustainable development of regions. Scientific evaluation of the coordination and analysis of similar reasons will improve the management level of decision-makers. The Coupling Coordination Degree model (CCD) developed on synergistic theory is now considered as a better method to evaluate coordination between systems. But, there are still some deficiencies. This paper attempts to improve the method in two aspects,: (1) introduce Full Permutation Polygon Synthesis Illustration method (FPPSI) to replace the two key steps of the present CCD model. To realize the data standardization and the comprehensive evaluation of system state, and to achieve the analysis of corresponding reasons. And (2) calculate the coupling coordination degrees of systems’ evolution speeds instead of comprehensive evaluation indexes, which will fully reflect the dynamic interaction between systems. To verify the feasibility of the method, Taihu Basin is taken as a case study. Results demonstrate that the improved CCD model is not only able to reflect the dynamic interaction between systems adequately, but also visually presents the specific reasons through geometrical illustration.

  19. Coordinating Permit Offices and the Development of Utility-Scale Geothermal Energy (Presentation)

    SciTech Connect

    Levine, A.; Young, K.; Witherbee, K.

    2013-10-01

    Permitting is a major component of the geothermal development process. Better coordination across government agencies could reduce uncertainty of the process and the actual time of permitting. This presentation highlights various forms of coordinating permit offices at the state and federal level in the western United States, discusses inefficiencies and mitigation techniques for permitting natural resource projects, analyzes whether various approaches are easily adaptable to utility-scale geothermal development, and addresses advantages and challenges for coordinating permit offices. Key successful strategies identified include: 1. Flexibility in implementing the approach (i.e. less statutory requirements for the approach); 2. Less dependence on a final environmental review for information sharing and permit coordination; 3. State and federal partnerships developed through memorandum of understanding to define roles and share data and/or developer information. A few of the most helpful techniques include: 1. A central point of contact for the developer to ask questions surrounding the project; 2. Pre-application meetings to assist the developer in identifying all of the permits, regulatory approvals, and associated information or data required; 3. A permit schedule or timeline to set expectations for the developer and agencies; 4. Consolidating the public notice, comment, and hearing period into fewer hearings held concurrently.

  20. On the Ethnic Origins of African Development: Chiefs and Precolonial Political Centralization

    PubMed Central

    Michalopoulos, Stelios; Papaioannou, Elias

    2015-01-01

    We report on recent findings of a fruitful research agenda that explores the importance of ethnic-specific traits in shaping African development. First, using recent surveys from Sub-Saharan African countries, we document that individuals identify with their ethnic group as often as with the nation pointing to the salience of ethnicity. Second, we focus on the various historical and contemporary functions of tribal leaders (chiefs) and illustrate their influence on various aspects of the economy and the polity. Third, we elaborate on a prominent dimension of ethnicity, that of the degree of complexity of pre-colonial political organization. Building on insights from the African historiography, we review recent works showing a strong association between pre-colonial centralization and contemporary comparative development both across and within countries. We also document that the link between pre-colonial political centralization and regional development -as captured by satellite images of light density at night-is particularly strong in areas outside the vicinity of the capitals, where due to population mixing and the salience of national institutions ethnic traits play a lesser role. Overall, our evidence is supportive to theories and narratives on the presence of a “dual” economic and institutional environment in Africa. PMID:27011760

  1. African land ecology: opportunities and constraints for agricultural development.

    PubMed

    Voortman, Roelf L; Sonneveld, Ben G J S; Keyzer, Michiel A

    2003-08-01

    Compared to other continents, the economic growth performance of Sub-Saharan Africa has been poor over the last four decades. Likewise, progress in agricultural development has been limited and the Green Revolution left Africa almost untouched. The question raised in the literature is whether the poor performance is a question of poor policies or of an unfavorable biophysical environment (policy versus destiny). This paper, with a broad perspective, analyzes adaptation of current land use to environmental conditions in Africa and compares the physical resource base of Africa with Asia. In doing so, we search for unifying principles that can have operational consequences for agricultural development. We argue that some specificities of the natural resource base, namely local homogeneity and spatial diversity of the predominant Basement Complex soils, imply that simple fertilizer strategies may not produce the yield increases obtained elsewhere.

  2. When "Prof" Speaks, Who Listens? The African Elite and the Use of African Languages for Education and Development in African Communities

    ERIC Educational Resources Information Center

    Trudell, Barbara

    2010-01-01

    The role of African languages in formal and nonformal learning is the subject of increasing local, national and international interests. Cognitive and pedagogical reasons abound for using the language best understood by the learner. However, many nonpedagogical factors related to politics, economics, language attitudes and colonial history are…

  3. African Mask-Making Workshop: Professional Development Experiences of Diverse Participants

    ERIC Educational Resources Information Center

    Rule, Audrey C.; Montgomery, Sarah E.; Kirkland-Holmes, Gloria; Watson, Dwight C.; Ayesiga, Yvonne

    2015-01-01

    Diverse education professionals learned about African cultures in a workshop experience by making African masks using authentic symbolism. Analysis of reflections to evaluate the workshop for applicability to participants with and without African heritage showed that both groups expanded their cultural knowledge of traditional African ethnic…

  4. Development of an Empirically Based Preventive Intervention for Depression in Preadolescent African American Girls.

    PubMed

    Duffy, Sophia; Brown, Tasha M; Katsonga-Phiri, Tiamo; Bouris, Alida; Grant, Kathryn E; Keenan, Kate

    2016-05-01

    We describe the development, feasibility, and acceptability of a novel preventive intervention for depression in African American girls living in urban poverty. Our approach targeted individual and interpersonal vulnerabilities that have been shown to confer risk for depression in samples of African American girls living in low-income, urban settings, including suppression of negative emotion and lack of assertiveness with peers, memory for positive emotion, active coping, and family connection. Focus groups and an open trial were conducted to refine the goals and mechanisms for skill building. A randomized controlled trial (RCT) of the new program (Cities Mother-Daughter Project) was conducted with 3rd-5th grade students from Chicago Public Schools (CPS). Three cycles of screening, randomization, and deployment were conducted to assess feasibility, satisfaction, and usability. Results indicate that feasibility was weak; whereas, satisfaction and usability were high. Future directions for testing efficacy are discussed. PMID:26846917

  5. Development of a Culturally Targeted Smoking Cessation Intervention for African American Smokers

    PubMed Central

    Matthews, Alicia K.; Sánchez-Johnsen, Lisa; King, Andrea

    2013-01-01

    In this paper we describe the development a culturally targeted (CT) smoking cessation intervention for low-to-middle income African–American smokers. Based on theoretically based guidelines, modifications were made to a standard treatment manual for group-based smoking cessation counseling that incorporates cognitive-behavioral, motivational, and twelve step skills. Approximately 41% of the standard treatment materials were modified, and four new modules were developed. A pilot study was conducted to compare acceptability, feasibility and early outcome indicates in African American smokers randomized to the CT intervention compared with existing data from African American smokers treated using a non-targeted standard approach (ST). Outcomes from the CT pilot study were promising: results showed high levels of feasibility, acceptability and better adherence to nicotine replacement therapy, higher quit rates, and better retention and follow-up compared with the ST. Findings suggest that a culturally targeted and intensive group based smoking cessation treatment is plausibly effective in improving smoking cessation outcomes in African American smokers, warranting a larger randomized trial. PMID:19728056

  6. The Complexity of Developing Properly Trained Education Professionals for African American Children: Exploring an African Indigenous Socialization Process

    ERIC Educational Resources Information Center

    Shockley, Kmt G.

    2011-01-01

    African centered educationists view the problems that Black children are facing in schools as a part of the disenfranchisement and disorganization of the Black community at large. In that vein, they do not believe that the problems which Black children are experiencing in America's public (and many private) schools are solvable by taking them out…

  7. Coordination of Organic Curriculum Development in the Public Schools of Portland, Oregon. Final Report.

    ERIC Educational Resources Information Center

    Ayers, Lawrence W., Jr.

    This document describes the efforts of program administrators to implement an organic curriculum in the John Adams High School in Portland, Oregon. The chief program administrator coordinated efforts to develop individualized instructional materials, to revamp school organization, and to create a fully differentiated staff. Organic curriculum is a…

  8. Transfer of Training in an Academic Leadership Development Program for Program Coordinators

    ERIC Educational Resources Information Center

    Ladyshewsky, Richard K.; Flavell, Helen

    2012-01-01

    The higher education sector has increasingly begun to pay more attention to academic leadership. This qualitative study explores how such an investment in a 20-week leadership development program influenced the behaviour of 10 academic staff in the role of program coordinator 6 to 12 months following participation in the program. Otherwise known…

  9. The Development of Coordinated Communication in Infants at Heightened Risk for Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Parladé, Meaghan V.; Iverson, Jana M.

    2015-01-01

    This study evaluated the extent to which developmental change in coordination of social communication in early infancy differentiates children eventually diagnosed with ASD from those not likely to develop the disorder. A prospective longitudinal design was used to compare nine infants at heightened risk for ASD (HR) later diagnosed with ASD, to…

  10. Physiologic Development of Tongue-Jaw Coordination from Childhood to Adulthood

    ERIC Educational Resources Information Center

    Cheng, Hei Yan; Murdoch, Bruce E.; Goozee, Justine V.; Scott, Dion

    2007-01-01

    Purpose: This investigation aimed to examine the development of tongue-jaw coordination during speech from childhood to adolescence. Method: Electromagnetic articulography was used to track tongue and jaw motion in 48 children and adults (aged 6-38 years) during productions of /t/ and /k/ embedded in sentences. Results: The coordinative…

  11. Coordination of Organic Curriculum Development in the Public Schools in Houston, Texas. Final Report.

    ERIC Educational Resources Information Center

    Pace, Arthur L.

    Between May 1967 and June 1970, the Houston Independent School District in consortium with 14 others contracted with USOE to coordinate the development of an organic curriculum. The project's purpose was to create a climate for change, while interpreting for Houston secondary schools the objectives of a plan that would be: relevant, based on…

  12. Recent developments in gold(I) coordination chemistry: luminescence properties and bioimaging opportunities.

    PubMed

    Langdon-Jones, Emily E; Pope, Simon J A

    2014-09-18

    The fascinating biological activity of gold coordination compounds has led to the development of a wide range of complexes. The precise biological action of such species is often poorly understood and the ability to map gold distribution in cellular environments is key. This article discusses the recent progress in luminescent Au(I) complexes whilst considering their utility in bioimaging and therapeutics.

  13. Enhancing Prospective Teachers' Coordination of Center and Spread: A Window into Teacher Education Material Development

    ERIC Educational Resources Information Center

    Lee, Hollylynne S.; Lee, J. Todd

    2011-01-01

    This paper describes a development and evaluation process used to create teacher education materials that help prepare middle and secondary mathematics teachers to teach data analysis and probability concepts with technology tools. One aspect of statistical reasoning needed for teaching is the ability to coordinate understandings of center and…

  14. Postnatal development of lateralized motor preference in the African grey parrot (Psittacus erithacus).

    PubMed

    Snyder, P J; Bonner, J A

    2001-01-01

    The parrot appears to provide a potentially unique animal model of handedness in humans, but few (if any) observational studies of early postnatal development of postural/motor asymmetries have been published. We studied three African Grey hatchlings, raised without human physical contact, for the first 5 months of life. All three animals failed to show consistent postural and/or motor asymmetries until the end of the 4 postnatal week. These results appear to be comparable to data from prior studies with human infants. Delayed development of lateral motor and/or postural preferences may represent an evolutionarily adaptive strategy for altricial animals.

  15. Contrasting a non-developing African mesoscale convective system with the precursor to Hurricane Helene (2006)

    NASA Astrophysics Data System (ADS)

    Rivera, G.; Fuentes, J. D.; Evans, J. L.; Hamilton, H. L.

    2015-12-01

    Mesoscale convective systems (MCSs) in West Africa traverse strong thermodynamic gradients during their westward propagation from land to ocean. Some of the systems continue to develop after crossing the coastline and may ultimately develop into tropical cyclones, while others do not. Understanding the lifecycle behavior of these convective systems and the factors that contribute to their continuous development as they transition from a continental environment to a marine environment poses a challenge. We examine the difference between two MCSs, one that continued to develop when it crossed the West African coast and one that did not, using European Centre for Medium-Range Weather Forecasts (ECMWF) Re-Analysis (ERA Interim) and Tropical Rainfall Measurement Mission (TRMM) 3B42 data. The non-developing MCS that intensified briefly while over land, weakened as soon as it crossed the coast. Preliminary results show that the developing MCS interacted with two cyclonic vortices, one associated with an African Easterly Wave that was propagating towards the coast and the other vortex generated by the topography near the coast.

  16. Developing community based rehabilitation for cancer survivors: organizing for coordination and coherence in practice

    PubMed Central

    2013-01-01

    Background Increasing incidences of cancer combined with prolonged survival have raised the need for developing community based rehabilitation. The objectives of the analysis were to describe and interpret the key issues related to coordination and coherence of community-based cancer rehabilitation in Denmark and to provide insights relevant for other contexts. Methods Twenty-seven rehabilitation managers across 15 municipalities in Denmark comprised the sample. The study was designed with a combination of data collection methods including questionnaires, individual interviews, and focus groups. A Grounded Theory approach was used to analyze the data. Results A lack of shared cultures among health care providers and systems of delivery was a primary barrier to collaboration which was essential for establishing coordination of care. Formal multidisciplinary steering committees, team-based organization, and informal relationships were fundamental for developing coordination and coherence. Conclusions Coordination and coherence in community-based rehabilitation relies on increased collaboration, which may best be optimized by use of shared frameworks within and across systems. Results highlight the challenges faced in practical implementation of community rehabilitation and point to possible strategies for its enhancement. PMID:24004881

  17. Collaboration, Communication and Co-ordination in Agile Software Development Practice

    NASA Astrophysics Data System (ADS)

    Robinson, Hugh; Sharp, Helen

    This chapter analyses the results of a series of observational studies of agile software developmentagile software development teams, identifying commonalities in collaboration, co-ordination and communication activities. Pairing and customer collaborationcustomer collaboration are focussed on to illustrate the nature of collaboration and communication, as are two simple physical artefacts that emerged through analysis as being an information-rich focal point for the co-ordination of collaboration and communication activities. The analysis shows that pairingpairing has common characteristics across all teams, while customer collaboration differs between the teams depending on the application and organisational context of development.

  18. The African Development Bank, structural adjustment, and child mortality: a cross-national analysis of Sub-Saharan Africa.

    PubMed

    Pandolfelli, Lauren E; Shandra, John M

    2013-01-01

    We conduct a cross-national analysis to test the hypothesis that African Development Bank (AfDB) structural adjustment adversely impacts child mortality in Sub-Saharan Africa. We use generalized least square random effects regression models and two-step Heckman models that correct for selection bias using data on 35 nations with up to four time points (1990, 1995, 2000, and 2005). We find substantial support for our hypothesis, which indicates that Sub-Saharan African nations that receive an AfDB structural adjustment loan tend to have higher levels of child mortality than Sub-Saharan African nations that do not receive such a loan. This finding remains stable even when controlling for selection bias on whether or not a Sub-Saharan African nation receives an AfDB structural adjustment loan. We conclude by discussing the methodological implications of the article, policy suggestions, and possible directions for future research.

  19. Deciding among Theories of the Development of Coordination in Child Speech. Papers and Reports on Child Language Development, No. 13.

    ERIC Educational Resources Information Center

    de Villiers, Jill; And Others

    The development of sentence coordination in children using sentences conjoined by "and" was studied to test the adequacy of the transformationally based derivational theory of complexity. Two cross-sectional experiments were conducted using 18 sentence types with children between the ages of three and five. One experiment used an elicited…

  20. 22 CFR 1508.620 - Do Federal agencies coordinate suspension and debarment actions?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Do Federal agencies coordinate suspension and debarment actions? 1508.620 Section 1508.620 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE... § 1508.620 Do Federal agencies coordinate suspension and debarment actions? Yes, when more than...

  1. Towards a Sustainable Counterbalanced Development: Educational Cooperation between China and African Countries

    ERIC Educational Resources Information Center

    Daddi, Ketema Meskela; Zhu, Hong

    2009-01-01

    In the last half a century an extensive cooperation between China and African countries have been launched, of which exchange and cooperation in education is one of the most important forms. In this aspect, China has played an important role in student exchange and education programs for African educational officials. However, African countries…

  2. A Case Study of the Development of African American Women Executives

    ERIC Educational Resources Information Center

    Brooks Greaux, Lisa

    2010-01-01

    Even in an era when the country elected an African American man as President of the United States, there is still a paucity of African American women executives within Fortune 500 companies. Although more African American women have joined the ranks of corporate management over the last two decades, the numbers, when compared to those of White…

  3. Development of the Little Developmental Coordination Disorder Questionnaire for Preschoolers and Preliminary Evidence of Its Psychometric Properties in Israel

    ERIC Educational Resources Information Center

    Rihtman, Tanya; Wilson, Brenda N.; Parush, Shula

    2011-01-01

    Purpose: The early identification of motor coordination challenges before school age may enable close monitoring of a child's development and perhaps ameliorate some of the social, psychological and behavioral sequela that often accompany unrecognized Developmental Coordination Disorder (DCD). The purpose of this study was to develop and assess…

  4. Text Messaging to Improve Hypertension Medication Adherence in African Americans: BPMED Intervention Development and Study Protocol

    PubMed Central

    Artinian, Nancy T; Schwiebert, Loren; Yarandi, Hossein; Levy, Phillip D

    2015-01-01

    Background Hypertension (HTN) is a major public health concern in the United States, with almost 78 million Americans age 20 years and over suffering from the condition. Moreover, HTN is a key risk factor for health disease and stroke. African Americans disproportionately shoulder the burdens of HTN, with greater prevalence, disease severity, earlier onset, and more HTN-related complications than age-matched whites. Medication adherence for the treatment of HTN is poor, with estimates indicating that only about half of hypertensive patients are adherent to prescribed medication regimens. Although no single intervention for improving medication adherence has emerged as superior to others, text message medication reminders have the potential to help improve medication adherence in African Americans with uncontrolled HTN as mobile phone adoption is very high in this population. Objective The purpose of this two-phased study was to develop (Phase I) and test in a randomized controlled trial (RCT) (Phase II) a text message system, BPMED, to improve the quality of medication management through increasing medication adherence in African Americans with uncontrolled HTN. Methods In Phase I, we recruited 16 target end-users from a primary care clinic, to assist in the development of BPMED through participating in one of three focus groups. Focus groups sought to gain patient perspectives on HTN, medication adherence, mobile phone use, and the use of text messaging to support medication adherence. Potential intervention designs were presented to participants, and feedback on the designs was solicited. In Phase II, we conducted two pilot RCTs to determine the feasibility, acceptability, and preliminary efficacy of BPMED in primary care and emergency department settings. Both pilot studies recruited approximately 60 participants, who were randomized equally between usual care and the BPMED intervention. Results Although data collection is now complete, data analysis from the

  5. Multimodality in infancy: vocal-motor and speech-gesture coordinations in typical and atypical development

    PubMed Central

    Iverson, Jana M.

    2011-01-01

    From very early in life, expressive behavior is multimodal, with early behavioral coordinations being refined and strengthened over time as they become used for the communication of meaning. Of these communicative coordinations, those that involve gesture and speech have received perhaps the greatest empirical attention, but little is known about the developmental origins of the gesture-speech link. One possibility is that the origins of speech-gesture coordinations lie in hand-mouth linkages that are observed in the everyday sensorimotor activity of very young infants who do not yet use the hand or mouth to communicate meaning. In this article, I review evidence suggesting that the study of gesture-speech links and developmentally prior couplings between the vocal and motor systems in infancy can provide valuable insight into a number of later developments that reflect the cognitive interdependence of gesture and speech. These include aspects of language development and delay, the infant origins of the adult speech-gesture system, and early signs of autism spectrum disorder. Implications of these findings for studying the development of multimodal communication are considered. PMID:21494413

  6. Protein levels and colony development of Africanized and European honey bees fed natural and artificial diets.

    PubMed

    Morais, M M; Turcatto, A P; Pereira, R A; Francoy, T M; Guidugli-Lazzarini, K R; Gonçalves, L S; de Almeida, J M V; Ellis, J D; De Jong, D

    2013-12-19

    Pollen substitute diets are a valuable resource for maintaining strong and health honey bee colonies. Specific diets may be useful in one region or country and inadequate or economically unviable in others. We compared two artificial protein diets that had been formulated from locally-available ingredients in Brazil with bee bread and a non-protein sucrose diet. Groups of 100 newly-emerged, adult workers of Africanized honey bees in Brazil and European honey bees in the USA were confined in small cages and fed on one of four diets for seven days. The artificial diets included a high protein diet made of soy milk powder and albumin, and a lower protein level diet consisting of soy milk powder, brewer's yeast and rice bran. The initial protein levels in newly emerged bees were approximately 18-21 µg/µL hemolymph. After feeding on the diets for seven days, the protein levels in the hemolymph were similar among the protein diet groups (~37-49 µg/µL after seven days), although Africanized bees acquired higher protein levels, increasing 145 and 100% on diets D1 and D2, respectively, versus 83 and 60% in the European bees. All the protein diets resulted in significantly higher levels of protein than sucrose solution alone. In the field, the two pollen substitute diets were tested during periods of low pollen availability in the field in two regions of Brazil. Food consumption, population development, colony weight, and honey production were evaluated to determine the impact of the diets on colony strength parameters. The colonies fed artificial diets had a significant improvement in all parameters, while control colonies dwindled during the dearth period. We conclude that these two artificial protein diets have good potential as pollen substitutes during dearth periods and that Africanized bees more efficiently utilize artificial protein diets than do European honey bees.

  7. FIDDLE: A Computer Code for Finite Difference Development of Linear Elasticity in Generalized Curvilinear Coordinates

    NASA Technical Reports Server (NTRS)

    Kaul, Upender K.

    2005-01-01

    A three-dimensional numerical solver based on finite-difference solution of three-dimensional elastodynamic equations in generalized curvilinear coordinates has been developed and used to generate data such as radial and tangential stresses over various gear component geometries under rotation. The geometries considered are an annulus, a thin annular disk, and a thin solid disk. The solution is based on first principles and does not involve lumped parameter or distributed parameter systems approach. The elastodynamic equations in the velocity-stress formulation that are considered here have been used in the solution of problems of geophysics where non-rotating Cartesian grids are considered. For arbitrary geometries, these equations along with the appropriate boundary conditions have been cast in generalized curvilinear coordinates in the present study.

  8. Need for a roadmap for development of a coordinated national registry programme.

    PubMed

    Wilkins, S; Best, R L; Evans, S M

    2015-11-01

    Clinical quality registries are an overlooked and under-funded arm of clinical research in Australia. Registries are databases for patients with a particular disease, or who undergo a procedure, or use a health resource. Registries, where properly funded and universally adopted, have provided substantial benefits to the quality of healthcare and, in some cases, have had demonstrable effect in reducing costs. There is a lack of a coordinated programme for both funding and development of registries in Australia. A coordinated effort is required to address key gaps in registry coverage and ensure registries comply with appropriate technical and operating principles, and target areas where registries can add value to the health system. This will ensure that Australia is competitive with its international peers in this dynamic environment.

  9. The role of coordination chemistry in the development of copper and rhenium radiopharmaceuticals.

    PubMed

    Donnelly, Paul S

    2011-02-01

    There are several isotopes of copper and rhenium that are of interest in the development of new molecular imaging or radiotherapeutic agents. This perspective article highlights the role of coordination chemistry in the design of copper and rhenium radiopharmaceuticals engineered to selectively target tissue of interest such as cancer cells or pathological features associated with Alzheimer's disease. The coordination chemistry of copper bis(thiosemicarbazone) derivatives and copper macrocyclic complexes is discussed in terms of their potential application as targeted positron emission tomography tracers for non-invasive diagnostic imaging. A range of rhenium complexes with different ligands with rhenium in different oxidation states are introduced and their potential to be translated to new radiotherapeutic agents discussed.

  10. The Ebola threat: China's response to the West African epidemic and national development of prevention and control policies and infrastructure.

    PubMed

    Fan, Hao-Jun; Gao, Hong-Wei; Ding, Hui; Zhang, Bi-Ke; Hou, Shi-Ke

    2015-02-01

    There is growing concern in West Africa about the spread of the Ebola hemorrhagic fever virus. With the increasing global public health risk, a coordinated international response is necessary. The Chinese government is prepared to work in collaboration with West African countries to assist in the containment and control of the epidemic through the contribution of medical expertise and mobile laboratory testing teams. Nationally, China is implementing prevention programs in major cities and provinces, the distribution of Ebola test kits, and the deployment of a new national Ebola research laboratory.

  11. The Ebola threat: China's response to the West African epidemic and national development of prevention and control policies and infrastructure.

    PubMed

    Fan, Hao-Jun; Gao, Hong-Wei; Ding, Hui; Zhang, Bi-Ke; Hou, Shi-Ke

    2015-02-01

    There is growing concern in West Africa about the spread of the Ebola hemorrhagic fever virus. With the increasing global public health risk, a coordinated international response is necessary. The Chinese government is prepared to work in collaboration with West African countries to assist in the containment and control of the epidemic through the contribution of medical expertise and mobile laboratory testing teams. Nationally, China is implementing prevention programs in major cities and provinces, the distribution of Ebola test kits, and the deployment of a new national Ebola research laboratory. PMID:25563862

  12. Addressing Low Colorectal Cancer Screening in African Americans: Using Focus Groups to Inform the Development of Effective Interventions.

    PubMed

    May, Folasade P; Whitman, Cynthia B; Varlyguina, Ksenia; Bromley, Erica G; Spiegel, Brennan M R

    2016-09-01

    African Americans have the highest burden of colorectal cancer (CRC) in the United States of America (USA) yet lower CRC screening rates than whites. Although poor screening has prompted efforts to increase screening uptake, there is a persistent need to develop public health interventions in partnership with the African American community. The aim of this study was to conduct focus groups with African Americans to determine preferences for the content and mode of dissemination of culturally tailored CRC screening interventions. In June 2013, 45-75-year-old African Americans were recruited through online advertisements and from an urban Veterans Affairs system to create four focus groups. A semi-structured interview script employing open-ended elicitation was used, and transcripts were analyzed using ATLAS.ti software to code and group data into a concept network. A total of 38 participants (mean age = 54) were enrolled, and 59 ATLAS.ti codes were generated. Commonly reported barriers to screening included perceived invasiveness of colonoscopy, fear of pain, and financial concerns. Facilitators included poor diet/health and desire to prevent CRC. Common sources of health information included media and medical providers. CRC screening information was commonly obtained from medical personnel or media. Participants suggested dissemination of CRC screening education through commercials, billboards, influential African American public figures, Internet, and radio. Participants suggested future interventions include culturally specific information, including details about increased risk, accessing care, and dispelling of myths. Public health interventions to improve CRC screening among African Americans should employ media outlets, emphasize increased risk among African Americans, and address race-specific barriers. Specific recommendations are presented for developing future interventions. PMID:25963898

  13. Addressing Low Colorectal Cancer Screening in African Americans: Using Focus Groups to Inform the Development of Effective Interventions.

    PubMed

    May, Folasade P; Whitman, Cynthia B; Varlyguina, Ksenia; Bromley, Erica G; Spiegel, Brennan M R

    2016-09-01

    African Americans have the highest burden of colorectal cancer (CRC) in the United States of America (USA) yet lower CRC screening rates than whites. Although poor screening has prompted efforts to increase screening uptake, there is a persistent need to develop public health interventions in partnership with the African American community. The aim of this study was to conduct focus groups with African Americans to determine preferences for the content and mode of dissemination of culturally tailored CRC screening interventions. In June 2013, 45-75-year-old African Americans were recruited through online advertisements and from an urban Veterans Affairs system to create four focus groups. A semi-structured interview script employing open-ended elicitation was used, and transcripts were analyzed using ATLAS.ti software to code and group data into a concept network. A total of 38 participants (mean age = 54) were enrolled, and 59 ATLAS.ti codes were generated. Commonly reported barriers to screening included perceived invasiveness of colonoscopy, fear of pain, and financial concerns. Facilitators included poor diet/health and desire to prevent CRC. Common sources of health information included media and medical providers. CRC screening information was commonly obtained from medical personnel or media. Participants suggested dissemination of CRC screening education through commercials, billboards, influential African American public figures, Internet, and radio. Participants suggested future interventions include culturally specific information, including details about increased risk, accessing care, and dispelling of myths. Public health interventions to improve CRC screening among African Americans should employ media outlets, emphasize increased risk among African Americans, and address race-specific barriers. Specific recommendations are presented for developing future interventions.

  14. Coordinated Development of Muscles and Tendon-Like Structures: Early Interactions in the Drosophila Leg

    PubMed Central

    Soler, Cedric; Laddada, Lilia; Jagla, Krzysztof

    2016-01-01

    The formation of the musculoskeletal system is a remarkable example of tissue assembly. In both vertebrates and invertebrates, precise connectivity between muscles and skeleton (or exoskeleton) via tendons or equivalent structures is fundamental for movement and stability of the body. The molecular and cellular processes underpinning muscle formation are well-established and significant advances have been made in understanding tendon development. However, the mechanisms contributing to proper connection between these two tissues have received less attention. Observations of coordinated development of tendons and muscles suggest these tissues may interact during the different steps in their development. There is growing evidence that, depending on animal model and muscle type, these interactions can take place from progenitor induction to the final step of the formation of the musculoskeletal system. Here, we briefly review and compare the mechanisms behind muscle and tendon interaction throughout the development of vertebrates and Drosophila before going on to discuss our recent findings on the coordinated development of muscles and tendon-like structures in Drosophila leg. By altering apodeme formation (the functional Drosophila equivalent of tendons in vertebrates) during the early steps of leg development, we affect the spatial localization of subsequent myoblasts. These findings provide the first evidence of the developmental impact of early interactions between muscle and tendon-like precursors, and confirm the appendicular Drosophila muscle system as a valuable model for studying these processes. PMID:26869938

  15. Regulatory challenges for GM crops in developing economies: the African experience.

    PubMed

    Nang'ayo, Francis; Simiyu-Wafukho, Stella; Oikeh, Sylvester O

    2014-12-01

    Globally, transgenic or genetically modified (GM) crops are considered regulated products that are subject to regulatory oversight during trans-boundary movement, testing and environmental release. In Africa, regulations for transgenic crops are based on the outcomes of the historic Earth Summit Conference held in Rio, Brazil two decades ago, namely, the adoption of the Convention on Biological Diversity (CBD) and the subsequent adoption of the Cartagena Protocol on Biosafety. To exploit the potential benefits of transgenic crops while safeguarding the potential risks on human health and environment, most African countries have signed and ratified the CBD and the Cartagena Protocol on Biosafety. Consequently, these countries are required to take appropriate legal, administrative and other measures to ensure that the handling and utilization of living modified organisms are undertaken in a manner that reduces the risks to humans and the environment. These countries are also expected to provide regulatory oversight on transgenic crops through functional national biosafety frameworks (NBFs). While in principle this approach is ideal, NBFs in most African countries are steeped in a host of policy, legal and operational challenges that appear to be at cross-purposes with the noble efforts of seeking to access, test and deliver promising GM crops for use by resource-limited farmers in Africa. In this paper we discuss the regulatory challenges faced during the development and commercialization of GM crops based on experiences from countries in Sub-Saharan Africa.

  16. African Primary Care Research: Choosing a topic and developing a proposal

    PubMed Central

    2014-01-01

    Abstract This is the first in a series of articles on primary care research in the African context. The aim of the series is to help build capacity for primary care research amongst the emerging departments of family medicine and primary care on the continent. Many of the departments are developing Masters of Medicine programmes in Family Medicine and their students will all be required to complete research studies as part of their degree. This series is being written with this audience in particular in mind – both the students who must conceptualise and implement a research project as well as their supervisors who must assist them. This article gives an overview of the African primary care context, followed by a typology of primary care research. The article then goes on to assist the reader with choosing a topic and defining their research question. Finally the article addresses the structure and contents of a research proposal and the ethical issues that should be considered. PMID:26245432

  17. African primary care research: choosing a topic and developing a proposal.

    PubMed

    Mash, Bob

    2014-02-06

    This is the first in a series of articles on primary care research in the African context. The aim of the series is to help build capacity for primary care research amongst the emerging departments of family medicine and primary care on the continent. Many of the departments are developing Masters of Medicine programmes in Family Medicine and their students will all be required to complete research studies as part of their degree. This series is being written with this audience in particular in mind--both the students who must conceptualise and implement a research project as well as their supervisors who must assist them.This article gives an overview of the African primary care context, followed by a typology of primary care research. The article then goes on to assist the reader with choosing a topic and defining their research question. Finally the article addresses the structure and contents of a research proposal and the ethical issues that should be considered.

  18. Managing Information for Development in the 21st Century: Prospects for African Libraries, Challenges to the World.

    ERIC Educational Resources Information Center

    Nwalo, Kenneth Ivo Ngozi

    This paper discusses the role information can play in the development of African countries in the 21st century. It stresses that development information can only be guaranteed when libraries in Africa computerize their systems, form networks for resource sharing, and take advantage of the benefits of information technology (IT), especially CD-ROM…

  19. The Influence of Cognitive Development and Perceived Racial Discrimination on the Psychological Well-Being of African American Youth

    ERIC Educational Resources Information Center

    Seaton, Eleanor K.

    2010-01-01

    The present study examined the influence of cognitive development in the relationship between multiple types of racial discrimination and psychological well-being. A sample of 322 African American adolescents (53% female), aged 13-18, completed measures of cognitive development, racial discrimination, self-esteem and depressive symptoms. Based on…

  20. The Development of Education Systems in Postcolonial Africa: A Study of a Selected Number of African Countries.

    ERIC Educational Resources Information Center

    Nieuwenhuis, F. J.

    This study traces educational policy development and implementation in the postcolonial era in eight sub-Saharan African countries. A basic premise is that the education system in any country is a result of interacting forces in the unique historical development of the country. The volume analyzes the forces in terms of their relevance and…

  1. A Study of First-Generation African American and Latino Undergraduates Developing Sociopolitical Consciousness in Introductory Sociology Classes

    ERIC Educational Resources Information Center

    Castillo-Montoya, Milagros

    2013-01-01

    This study examines the development of first-generation African American and Latino college students' sociopolitical consciousness in the context of their learning of sociology as a component of their liberal education studies. Given the paucity of research on how college students develop sociopolitical consciousness, this study addresses: (1) the…

  2. 22 CFR 1508.645 - Do other Federal agencies know if the African Development Foundation agrees to a voluntary...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Development Foundation agrees to a voluntary exclusion? 1508.645 Section 1508.645 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General Principles Relating to... Foundation agrees to a voluntary exclusion? (a) Yes, we enter information regarding a voluntary...

  3. 22 CFR 1508.645 - Do other Federal agencies know if the African Development Foundation agrees to a voluntary...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Development Foundation agrees to a voluntary exclusion? 1508.645 Section 1508.645 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General Principles Relating to... Foundation agrees to a voluntary exclusion? (a) Yes, we enter information regarding a voluntary...

  4. 22 CFR 1508.645 - Do other Federal agencies know if the African Development Foundation agrees to a voluntary...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Development Foundation agrees to a voluntary exclusion? 1508.645 Section 1508.645 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General Principles Relating to... Foundation agrees to a voluntary exclusion? (a) Yes, we enter information regarding a voluntary...

  5. 22 CFR 1508.645 - Do other Federal agencies know if the African Development Foundation agrees to a voluntary...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Development Foundation agrees to a voluntary exclusion? 1508.645 Section 1508.645 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General Principles Relating to... Foundation agrees to a voluntary exclusion? (a) Yes, we enter information regarding a voluntary...

  6. 22 CFR 1508.645 - Do other Federal agencies know if the African Development Foundation agrees to a voluntary...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Development Foundation agrees to a voluntary exclusion? 1508.645 Section 1508.645 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General Principles Relating to... Foundation agrees to a voluntary exclusion? (a) Yes, we enter information regarding a voluntary...

  7. The African Capacity Building Initiative: Toward Improved Policy Analysis and Development Management in Sub-Saharan Africa.

    ERIC Educational Resources Information Center

    World Bank, Washington, DC.

    The objective of the African Capacity Building Initiative is to build and strengthen local capabilities for policy analysis and development management in Sub-Saharan Africa. This report examines the nature and magnitude of the problem, which basically consists of a shortage of development management skills combined with weakness in the area of…

  8. Some Notes on the Teaching of African and Latin American Politics and Political Development in the United States

    ERIC Educational Resources Information Center

    Kenski, Henry C.; Kenski, Margaret Corgan

    1976-01-01

    Presents comparative 1973 survey data on teaching African politics, Latin American politics, and political development courses in the United States. The authors investigated the (1) use of teaching techniques and evaluation of their effectiveness, and (2) theoretical approaches to political development that were found useful. (Author/ND)

  9. Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex

    PubMed Central

    Rapoport, Stanley I.; Primiani, Christopher T.; Chen, Chuck T.; Ahn, Kwangmi; Ryan, Veronica H.

    2015-01-01

    Background Phosphoinositides, lipid-signaling molecules, participate in diverse brain processes within a wide metabolic cascade. Hypothesis Gene transcriptional networks coordinately regulate the phosphoinositide cascade during human brain Development and Aging. Methods We used the public BrainCloud database for human dorsolateral prefrontal cortex to examine age-related expression levels of 49 phosphoinositide metabolic genes during Development (0 to 20+ years) and Aging (21+ years). Results We identified three groups of partially overlapping genes in each of the two intervals, with similar intergroup correlations despite marked phenotypic differences between Aging and Development. In each interval, ITPKB, PLCD1, PIK3R3, ISYNA1, IMPA2, INPPL1, PI4KB, and AKT1 are in Group 1, PIK3CB, PTEN, PIK3CA, and IMPA1 in Group 2, and SACM1L, PI3KR4, INPP5A, SYNJ1, and PLCB1 in Group 3. Ten of the genes change expression nonlinearly during Development, suggesting involvement in rapidly changing neuronal, glial and myelination events. Correlated transcription for some gene pairs likely is facilitated by colocalization on the same chromosome band. Conclusions Stable coordinated gene transcriptional networks regulate brain phosphoinositide metabolic pathways during human Development and Aging. PMID:26168237

  10. Racism, Racial Resilience, and African American Youth Development: Person-Centered Analysis as a Tool to Promote Equity and Justice.

    PubMed

    Neblett, Enrique W; Sosoo, Effua E; Willis, Henry A; Bernard, Donte L; Bae, Jiwoon; Billingsley, Janelle T

    2016-01-01

    Racism constitutes a significant risk to the healthy development of African American youth. Fortunately, however, not all youth who experience racism evidence negative developmental outcomes. In this chapter, we examine person-centered analysis (PCA)-a quantitative technique that investigates how variables combine across individuals-as a useful tool for elucidating racial and ethnic protective processes that mitigate the negative impact of racism. We review recent studies employing PCA in examinations of racial identity, racial socialization, and other race-related experiences, as well as how these constructs correlate with and impact African American youth development. We also consider challenges and limitations of PCA and conclude with a discussion of future research and how PCA might be used to promote equity and justice for African American and other racial and ethnic minority youth who experience racism.

  11. Racism, Racial Resilience, and African American Youth Development: Person-Centered Analysis as a Tool to Promote Equity and Justice.

    PubMed

    Neblett, Enrique W; Sosoo, Effua E; Willis, Henry A; Bernard, Donte L; Bae, Jiwoon; Billingsley, Janelle T

    2016-01-01

    Racism constitutes a significant risk to the healthy development of African American youth. Fortunately, however, not all youth who experience racism evidence negative developmental outcomes. In this chapter, we examine person-centered analysis (PCA)-a quantitative technique that investigates how variables combine across individuals-as a useful tool for elucidating racial and ethnic protective processes that mitigate the negative impact of racism. We review recent studies employing PCA in examinations of racial identity, racial socialization, and other race-related experiences, as well as how these constructs correlate with and impact African American youth development. We also consider challenges and limitations of PCA and conclude with a discussion of future research and how PCA might be used to promote equity and justice for African American and other racial and ethnic minority youth who experience racism. PMID:27474422

  12. Co-ordination of Flower Development Through Epigenetic Regulation in Two Model Species: Rice and Arabidopsis.

    PubMed

    Guo, Siyi; Sun, Bo; Looi, Liang-Sheng; Xu, Yifeng; Gan, Eng-Seng; Huang, Jiangbo; Ito, Toshiro

    2015-05-01

    Angiosperms produce flowers for reproduction. Flower development is a multistep developmental process, beginning with the initiation of the floral meristems, followed by floral meristem identity specification and maintenance, organ primordia initiation, floral organ identity specification, floral stem cell termination and finally floral organ maturation. During flower development, each of a large number of genes is expressed in a spatiotemporally regulated manner. Underlying these molecular and phenotypic events are various genetic and epigenetic pathways, consisting of diverse transcription factors, chromatin-remodeling factors and signaling molecules. Over the past 30 years, genetic, biochemical and genomic assays have revealed the underlying genetic frameworks that control flower development. Here, we will review the transcriptional regulation of flower development in two model species: Arabidopsis thaliana and rice (Oryza sativa). We focus on epigenetic regulation that functions to co-ordinate transcription pathways in flower development.

  13. Cranial nerve development requires co-ordinated Shh and canonical Wnt signaling.

    PubMed

    Kurosaka, Hiroshi; Trainor, Paul A; Leroux-Berger, Margot; Iulianella, Angelo

    2015-01-01

    Cranial nerves govern sensory and motor information exchange between the brain and tissues of the head and neck. The cranial nerves are derived from two specialized populations of cells, cranial neural crest cells and ectodermal placode cells. Defects in either cell type can result in cranial nerve developmental defects. Although several signaling pathways are known to regulate cranial nerve formation our understanding of how intercellular signaling between neural crest cells and placode cells is coordinated during cranial ganglia morphogenesis is poorly understood. Sonic Hedgehog (Shh) signaling is one key pathway that regulates multiple aspects of craniofacial development, but whether it co-ordinates cranial neural crest cell and placodal cell interactions during cranial ganglia formation remains unclear. In this study we examined a new Patched1 (Ptch1) loss-of-function mouse mutant and characterized the role of Ptch1 in regulating Shh signaling during cranial ganglia development. Ptch1(Wig/ Wig) mutants exhibit elevated Shh signaling in concert with disorganization of the trigeminal and facial nerves. Importantly, we discovered that enhanced Shh signaling suppressed canonical Wnt signaling in the cranial nerve region. This critically affected the survival and migration of cranial neural crest cells and the development of placodal cells as well as the integration between neural crest and placodes. Collectively, our findings highlight a novel and critical role for Shh signaling in cranial nerve development via the cross regulation of canonical Wnt signaling. PMID:25799573

  14. Cranial Nerve Development Requires Co-Ordinated Shh and Canonical Wnt Signaling

    PubMed Central

    Kurosaka, Hiroshi; Trainor, Paul A.; Leroux-Berger, Margot; Iulianella, Angelo

    2015-01-01

    Cranial nerves govern sensory and motor information exchange between the brain and tissues of the head and neck. The cranial nerves are derived from two specialized populations of cells, cranial neural crest cells and ectodermal placode cells. Defects in either cell type can result in cranial nerve developmental defects. Although several signaling pathways are known to regulate cranial nerve formation our understanding of how intercellular signaling between neural crest cells and placode cells is coordinated during cranial ganglia morphogenesis is poorly understood. Sonic Hedgehog (Shh) signaling is one key pathway that regulates multiple aspects of craniofacial development, but whether it co-ordinates cranial neural crest cell and placodal cell interactions during cranial ganglia formation remains unclear. In this study we examined a new Patched1 (Ptch1) loss-of-function mouse mutant and characterized the role of Ptch1 in regulating Shh signaling during cranial ganglia development. Ptch1Wig/ Wig mutants exhibit elevated Shh signaling in concert with disorganization of the trigeminal and facial nerves. Importantly, we discovered that enhanced Shh signaling suppressed canonical Wnt signaling in the cranial nerve region. This critically affected the survival and migration of cranial neural crest cells and the development of placodal cells as well as the integration between neural crest and placodes. Collectively, our findings highlight a novel and critical role for Shh signaling in cranial nerve development via the cross regulation of canonical Wnt signaling. PMID:25799573

  15. Opg, Rank, and Rankl in tooth development: co-ordination of odontogenesis and osteogenesis.

    PubMed

    Ohazama, A; Courtney, J-M; Sharpe, P T

    2004-03-01

    Osteoprotegerin (OPG), receptor activator of nuclear factor-kappaB (RANK), and RANK ligand (RANKL) are mediators of various cellular interactions, including bone metabolism. We analyzed expression of these three genes during murine odontogenesis from epithelial thickening to cytodifferentiation stages. Opg showed expression in the thickening and bud epithelium. Expression of Opg and Rank was observed in both the internal and the external enamel epithelium as well as in the dental papilla mesenchyme. Although Rankl expression was not detected in tooth epithelium or mesenchyme, it was expressed in pre-osteogenic mesenchymal cells close to developing tooth germs. All three genes were detected in developing dentary bone at P0. The addition of exogenous OPG to explant cultures of tooth primordia produced a delay in tooth development that resulted in reduced mineralization. We propose that the spatiotemporal expression of these molecules in early tooth and bone primordia cells has a role in co-ordinating bone and tooth development.

  16. Guiding language development: how African American mothers and their infants structure play interactions.

    PubMed

    Hammer, C S; Weiss, A L

    1999-10-01

    This investigation explored how African American mothers and their infants at the single-word stage of development structured their play and communicated with one another. Six mother-child dyads of low socioeconomic status (SES) and six of middle SES were observed at play. Few group differences were found, with the majority of the differences involving language behaviors. The middle-SES dyads included language goals more often in their play. Middle-SES infants initiated play verbally more frequently and produced over twice as many vocalizations as their low-SES peers. In addition, middle-SES mothers used a wider variety of words when playing with their children than their low-SES counterparts. A range of play styles was found within both groups. These were categorized into three general play styles: mothers and children actively involved in play; mothers' involvement varied; and children actively engaged and mothers attentive.

  17. Early educational foundations for the development of civic responsibility: an African experience.

    PubMed

    Serpell, Robert; Mumba, Paul; Chansa-Kabali, Tamara

    2011-01-01

    An innovative curriculum designed to foster the development of social responsibility among pre-adolescent children was introduced at a rural Zambian primary school. The curriculum invoked Child-to-Child principles focusing on health education, advancing a synthesis of Western psychological theories and African cultural traditions. The teacher sought to democratize the educational process through cooperative learning in mixed-gender, mixed-social-class, and mixed-ability study groups. Learners engaged in community service activities and contributed to the nurturant care of younger children. Young adults interviewed seventeen years after completing the program recalled their experience and reflected on how it had promoted their personal agency, cooperative disposition, and civic responsibility in early adulthood.

  18. African Aesthetics

    ERIC Educational Resources Information Center

    Abiodun, Rowland

    2001-01-01

    No single traditional discipline can adequately supply answers to the many unresolved questions in African art history. Because of the aesthetic, cultural, historical, and, not infrequently, political biases, already built into the conception and development of Western art history, the discipline of art history as defined and practiced in the West…

  19. Developmental and ethnic issues experienced by emerging adult African American women related to developing a mature love relationship.

    PubMed

    Tyson, Sheryl Y

    2012-01-01

    This qualitative study explored perspectives of emerging adult African American women on the development of mature love relationships. Inductive analysis of focus group interviews, conducted with a purposive sample of 31 African American women, yielded themes related to relationship goals and characteristics, and interpersonal and societal challenges to finding the right partner and developing a mature love relationship. Core categories that emerged from analysis of the discussions were (1) age and relationship goal differences within the emerging adult group, (2) mature love relationship goals and characteristics, (3) interpersonal obstacles to finding the right partner, and (4) societal obstacles to finding the right partner. Two approaches-black womanist/feminist thought (Collins, 2000 ; Walker, 1983 ) and relationship maturity theory (Paul & White, 1990 )-were then combined to explain the influence of historic and contemporary interpersonal and societal factors on developmental and ethnic issues that challenge positive gender identity formation, hasten intimacy maturity, and hinder the development of mature love relationships among emerging adult African American women. For these women, premature responsibility, especially early caregiver burden, was related to the early development of intimacy capacity and the desire for a mature love relationship, to be protected, and to have someone to help carry the load. Interracial dating, negative stereotypic images of African American women, and even positive images of enduring black love relationships posed difficult challenges to positive identity formation and intimacy maturity. A primary challenge was to counteract negative stereotypic images, so that they could develop their own self-identities as women and as relationship partners.

  20. Motor skills in Brazilian children with developmental coordination disorder versus children with motor typical development.

    PubMed

    Cardoso, Ana Amélia; Magalhães, Livia Castro; Rezende, Marcia Bastos

    2014-12-01

    The aims of the study were to compare the performance of children with probable developmental coordination disorder (DCD) and motor typically developing peers on items from the Assessment of Motor Coordination and Dexterity (AMCD), to determine whether age, gender and type of school had significant impact on the scores of the AMCD items, to estimate the frequency of DCD among Brazilian children ages 7 and 8 years and to investigate whether children with DCD exhibit more symptoms of attention deficit and hyperactivity disorder than children with motor typical development. A total of 793 children were screened by the Developmental Coordination Disorder Questionnaire - Brazilian version (DCDQ-Brazil); 90 were identified as at risk for DCD; 91 matched controls were selected from the remaining participants. Children in both groups were evaluated with the AMCD, the Movement Assessment Battery for Children (MABC-II) and Raven's coloured progressive matrices. Thirty-four children were classified as probable DCD, as defined by a combination of the DCDQ-Brazil and MABC-II scores (fifth percentile). The final frequency of DCD among children ages 7 and 8 years was 4.3%. There were significant differences between children with and without DCD on the majority of AMCD items, indicating its potential for identifying DCD in Brazilian children. The use of a motor test (MABC-II) that is not validated for the Brazilian children is a limitation of the present study. Further studies should investigate whether the AMCD is useful for identifying DCD in other age groups and in children from different regions of Brazil. The application of the AMCD may potentially contribute in improving occupational therapy practice in Brazil and in identifying children that could benefit from occupational therapy services.

  1. Inverse Effects on Growth and Development Rates by Means of Endocrine Disruptors in African Clawed Frog Tadpoles ("Xenopus Laevis")

    ERIC Educational Resources Information Center

    Hackney, Zachary Carl

    2007-01-01

    Previous work on fish, frogs, and salamanders, showed the ability for estrogen (EE2) and anthropogenic endocrine disruptors to skew sex ratios and cause hermaphrodism. This study addressed the effects of estrogens on growth and development rates of African clawed frog tadpoles ("Xenopus laevis") during their gender determination stages. The…

  2. The Impact of Racial Identity and Consciousness Development on African American Female Academic Achievement: Implications for Counseling

    ERIC Educational Resources Information Center

    Glass, Charles R.

    2007-01-01

    The purpose of this study will be to examine the effect of racial identity/consciousness (RIC) on the academic achievement of African American female college freshmen. This causal-comparative study is intended to provide research based info ration concerning the impact of racial identity/consciousness development on the academic achievement of…

  3. Service Quality and Students' Satisfaction with the Professional Teacher Development Programmes by Distance Mode in a South African University

    ERIC Educational Resources Information Center

    Oduaran, A. B.

    2011-01-01

    This article reports on the relationship between seven factors that described dimensions of education service quality and overall service quality on one hand, and students' satisfaction with the professional teacher development programmes by distance mode in a South African University on the other. We sought to find out whether students enrolled…

  4. The Development of a Freshman Orientation Course for African-American Students with a Focus on Afrocentricity.

    ERIC Educational Resources Information Center

    Daughtry, Leslie M.

    To address the needs of African American students at Beaver College in Glenside (Pennsylvania), a one-credit freshman orientation course on Afrocentricity was developed. The course was intended to increase the comfort level between the institution and its culturally diverse students and add additional support for increased retention of African…

  5. Circles of Care: Development and Initial Evaluation of a Peer Support Model for African Americans with Advanced Cancer

    ERIC Educational Resources Information Center

    Hanson, Laura C.; Armstrong, Tonya D.; Green, Melissa A.; Hayes, Michelle; Peacock, Stacie; Elliot-Bynum, Sharon; Goldmon, Moses V.; Corbie-Smith, Giselle; Earp, Jo Anne

    2013-01-01

    Peer support interventions extend care and health information to underserved populations yet rarely address serious illness. Investigators from a well-defined academic-community partnership developed and evaluated a peer support intervention for African Americans facing advanced cancer. Evaluation methods used the Reach, Efficacy, Adoption,…

  6. A Comparison of Oral and Written English Styles in African American Students at Different Stages of Writing Development

    ERIC Educational Resources Information Center

    Ivy, Lennette J.; Masterson, Julie J.

    2011-01-01

    Purpose: The purpose of this investigation was to compare the rates of using African American English (AAE) grammatical features in spoken and written language at different points in literacy development. Based on Kroll's model (1981), a high degree of similarity in use between the modalities was expected at Grade 3, and lower similarity was…

  7. Improving Ground Penetrating Radar Imaging in High Loss Environments by Coordinated System Development, Data Processing, Numerical Modeling, & Visualization

    SciTech Connect

    Wright, David L.

    2004-12-01

    Improving Ground Penetrating Radar Imaging in High Loss Environments by Coordinated System Development, Data Processing, Numerical Modeling, and Visualization Methods with Applications to Site Characterization EMSP Project 86992 Progress Report as of 9/2004.

  8. Sustainable Development and African Local Government: Can Electronic Training Help Build Capacities?

    ERIC Educational Resources Information Center

    Johnson, Hazel; Thomas, Alan

    2007-01-01

    A recent study carried out by European and African organizations into the potential for electronic distance training (EDT) on sustainability in African local governments concluded that EDT was both "useful and feasible". This article reflects on some of the theoretical and practical implications of that study. It focuses on the connection between…

  9. Reexaming the Development of African American English: Evidence from Isolated Communities.

    ERIC Educational Resources Information Center

    Wolfram, Walt

    2003-01-01

    Examines several longstanding, isolated biracial sociolinguistic situations in the coastal and Appalachian regions of North Carolina: a core community of African Americans and two case studies of isolated speakers. Compares diagnostic phonological and morphosyntactic variables for speakers representing different generations of African American and…

  10. African American Students in Private, Independent Schools: Parents and School Influences on Racial Identity Development

    ERIC Educational Resources Information Center

    DeCuir-Gunby, Jessica T.; Martin, Pamela P.; Cooper, Shauna M.

    2012-01-01

    Although much research has focused on the public school experiences of African American students, few studies exist that explore their race-related experiences within an independent, private school context. Studies have suggested that, while private, independent schools may elevate the quality of African American students' education, many of these…

  11. Developing Long-Term Physical Activity Participation: A Grounded Theory Study with African American Women

    ERIC Educational Resources Information Center

    Harley, Amy E.; Buckworth, Janet; Katz, Mira L.; Willis, Sharla K.; Odoms-Young, Angela; Heaney, Catherine A.

    2009-01-01

    Regular physical activity is linked to a reduced risk of obesity and chronic disease. African American women bear a disproportionate burden from these conditions and many do not get the recommended amount of physical activity. Long-term success of interventions to initiate and maintain a physically active lifestyle among African American women has…

  12. Formative research to develop a lifestyle application (app) for African American breast cancer survivors

    PubMed Central

    Smith, Selina A.; Whitehead, Mary S.; Sheats, Joyce Q.; Fontenot, Brittney; Alema-Mensah, Ernest; Ansa, Benjamin

    2016-01-01

    Background There is a proliferation of lifestyle-oriented mobile technologies; however, few have targeted users. Through intervention mapping, investigators and community partners completed Steps 1–3 (needs assessment, formulation of change objectives, and selection of theory-based methods) of a process to develop a mobile cancer prevention application (app) for cancer prevention. The aim of this qualitative study was to complete Step 4 (intervention development) by eliciting input from African American (AA) breast cancer survivors (BCSs) to guide app development. Methods Four focus group discussions (n=60) and three individual semi-structured interviews (n=36) were conducted with AA BCSs (40–72 years of age) to assess barriers and strategies for lifestyle change. All focus groups and interviews were recorded and transcribed verbatim. Data were analyzed with NVivo qualitative data analysis software version 10, allowing categories, themes, and patterns to emerge. Results Three categories and related themes emerged from the analysis: 1) perceptions about modifiable risk factors; 2) strategies related to adherence to cancer prevention guidelines; and 3) app components to address barriers to adherence. Participant perceptions, strategies, and recommended components guided development of the app. Conclusions For development of a mobile cancer prevention app, these findings will assist investigators in targeting features that are usable, acceptable, and accessible for AA BCSs. PMID:27583307

  13. Coordinated changes in dendritic arborization and synaptic strength during neural circuit development

    PubMed Central

    Peng, Yi-Rong; He, Shan; Marie, Helene; Zeng, Si-Yu; Ma, Jun; Tan, Zhu-Jun; Lee, Soo Yeun; Malenka, Robert C.; Yu, Xiang

    2009-01-01

    Neural circuit development requires concurrent morphological and functional changes. Here we identify coordinated and inversely correlated changes in dendritic morphology and mEPSC amplitude following increased neural activity. We show that over-expression of β-catenin, a molecule that increases total dendritic length, mimics the effects of increased neuronal activity by scaling down mEPSC amplitudes, while postsynaptic expression of a protein that sequesters β-catenin reverses the effects of activity on reducing mEPSC amplitudes. These results were confirmed immunocytochemically as changes in the size and density of surface synaptic AMPA receptor clusters. In individual neurons there was an inverse linear relationship between total dendritic length and average mEPSC amplitude. Importantly, β-catenin over-expression in vivo promoted dendritic growth and reduced mEPSC amplitudes. Together, these results demonstrate that coordinated changes in dendritic morphology and unitary excitatory synaptic strength may serve as an important intrinsic mechanism that helps prevent neurons from over-excitation during neural circuit development. PMID:19146814

  14. Nitric oxide coordinates cell proliferation and cell movements during early development of Xenopus.

    PubMed

    Peunova, Natalia; Scheinker, Vladimir; Ravi, Kandasamy; Enikolopov, Grigori

    2007-12-15

    The establishment of a vertebrate body plan during embryogenesis is achieved through precise coordination of cell proliferation and morphogenetic cell movements. Here we show that nitric oxide (NO) suppresses cell division and facilitates cell movements during early development of Xenopus, such that inhibition of NO synthase (NOS) increases proliferation in the neuroectoderm and suppresses convergent extension in the axial mesoderm and neuroectoderm. NO controls cell division and cell movement through two separate signaling pathways. Both rely on RhoA-ROCK signaling but can be distinguished by the involvement of either guanylate cyclase or the planar cell polarity regulator Dishevelled. Through the cGMP-dependent pathway, NO suppresses cell division by negatively regulating RhoA and controlling the nuclear distribution of ROCK and p21WAF1. Through the cGMP-independent pathway, NO facilitates cell movement by regulating the intracellular distribution and level of Dishevelled and the activity of RhoA, thereby controlling the activity of ROCK and regulating actin cytoskeleton remodeling and cell polarization. Concurrent control by NO helps ensure that the crucial processes of cell proliferation and morphogenetic movements are coordinated during early development.

  15. Balancing Water Uptake and Loss through the Coordinated Regulation of Stomatal and Root Development.

    PubMed

    Hepworth, Christopher; Turner, Carla; Landim, Marcela Guimaraes; Cameron, Duncan; Gray, Julie E

    2016-01-01

    Root development is influenced by nutrient and water availabilities. Plants are able to adjust many attributes of their root in response to environmental signals including the size and shape of the primary root, lateral roots and root hairs. Here we investigated the response of roots to changes in the levels of leaf transpiration associated with altered stomatal frequency. We found that plants with high stomatal density and conductance produce a larger rooting area and as a result have enhanced phosphate uptake capacity whereas plants with low stomatal conductance produce a smaller root. Manipulating the growth environment of plants indicated that enhanced root growth is most likely a result of an increased demand for water rather than phosphate. Plants manipulated to have an increase or reduction in root hair growth show a reduction or increase respectively, in stomatal conductance and density. Our results demonstrate that plants can balance their water uptake and loss through coordinated regulation of both stomatal and root development. PMID:27275842

  16. Promoting Coordinated Development of Community-Based Information Standards for Modeling in Biology: The COMBINE Initiative

    PubMed Central

    Hucka, Michael; Nickerson, David P.; Bader, Gary D.; Bergmann, Frank T.; Cooper, Jonathan; Demir, Emek; Garny, Alan; Golebiewski, Martin; Myers, Chris J.; Schreiber, Falk; Waltemath, Dagmar; Le Novère, Nicolas

    2015-01-01

    The Computational Modeling in Biology Network (COMBINE) is a consortium of groups involved in the development of open community standards and formats used in computational modeling in biology. COMBINE’s aim is to act as a coordinator, facilitator, and resource for different standardization efforts whose domains of use cover related areas of the computational biology space. In this perspective article, we summarize COMBINE, its general organization, and the community standards and other efforts involved in it. Our goals are to help guide readers toward standards that may be suitable for their research activities, as well as to direct interested readers to relevant communities where they can best expect to receive assistance in how to develop interoperable computational models. PMID:25759811

  17. Balancing Water Uptake and Loss through the Coordinated Regulation of Stomatal and Root Development

    PubMed Central

    Hepworth, Christopher; Turner, Carla; Landim, Marcela Guimaraes; Cameron, Duncan; Gray, Julie E.

    2016-01-01

    Root development is influenced by nutrient and water availabilities. Plants are able to adjust many attributes of their root in response to environmental signals including the size and shape of the primary root, lateral roots and root hairs. Here we investigated the response of roots to changes in the levels of leaf transpiration associated with altered stomatal frequency. We found that plants with high stomatal density and conductance produce a larger rooting area and as a result have enhanced phosphate uptake capacity whereas plants with low stomatal conductance produce a smaller root. Manipulating the growth environment of plants indicated that enhanced root growth is most likely a result of an increased demand for water rather than phosphate. Plants manipulated to have an increase or reduction in root hair growth show a reduction or increase respectively, in stomatal conductance and density. Our results demonstrate that plants can balance their water uptake and loss through coordinated regulation of both stomatal and root development. PMID:27275842

  18. Developing Efficient Coordination Schemes to Control Over-Pumping in the Heihe River Basin, China

    NASA Astrophysics Data System (ADS)

    Pedrazzini, G.

    2015-12-01

    Many wicked water resources problems are approached in a social planner perspective. This not always matches the real institutional and policy-making context, where, rather, multiple decision-makers (DMs) can act independently, or weakly cooperate, ultimately producing system-wide inefficient trade-offs. The idea in this work is to adopt a more realistic approach, where the multi-DMs nature of the problem is preserved and the uncoordinated DMs are driven, thorough coordination mechanisms, towards a more system-wide efficient solution. An agent-based modelling framework linked to a surface and groundwater model is used to design these coordination mechanisms as constraints to the independent agents (i.e., DMs) behaviour. In the Heihe Basin the ongoing introduction of smart meter IC-card systems on farmers' pumping wells will soon allow monitoring and control of abstractions with the goal of preventing further depletion of the resource. The major interest of policy makers in the region concerns the development of new and the improvement of existing legislation on pricing schemes and/or groundwater quotas. The model outcome where agents act rationally but selfishly is compared to the optimal solution at system-level assuming perfect coordination and cooperation. The optimal solutions with respect to the given utility functions are computed using nonlinear optimization with a rolling out time horizon. The Pareto-Frontier is synthesized through an exhaustive sampling of the weight coefficient space and related to the current and to the historical management of the last 4 decades. The best parameter values for the proposed coordination mechanisms are determined and the alternatives are compared with respect to their efficiency and acceptability. Preliminary results suggest that a regulatory tax on groundwater of about a factor 10 of the current resource fee is required to increase the elasticity of the groundwater demand curve such that reducing consumption becomes

  19. Mice lacking the transcription factor SHOX2 display impaired cerebellar development and deficits in motor coordination.

    PubMed

    Rosin, Jessica M; McAllister, Brendan B; Dyck, Richard H; Percival, Christopher J; Kurrasch, Deborah M; Cobb, John

    2015-03-01

    Purkinje cells of the developing cerebellum secrete the morphogen sonic hedgehog (SHH), which is required to maintain the proliferative state of granule cell precursors (GCPs) prior to their differentiation and migration to form the internal granule layer (IGL). Despite a wealth of knowledge regarding the function of SHH during cerebellar development, the upstream regulators of Shh expression during this process remain largely unknown. Here we report that the murine short stature homeobox 2 (Shox2) gene is required for normal Shh expression in dorsal-residing Purkinje cells. Using two different Cre drivers, we show that elimination of Shox2 in the brain results in developmental defects in the inferior colliculus and cerebellum. Specifically, loss of Shox2 in the cerebellum results in precocious differentiation and migration of GCPs from the external granule layer (EGL) to the IGL. This correlates with premature bone morphogenetic protein 4 (Bmp4) expression in granule cells of the dorsal cerebellum. The size of the neonatal cerebellum is reduced in Shox2-mutant animals, which is consistent with a reduction in the number of GCPs present in the EGL, and could account for the smaller vermis and thinner IGL present in adult Shox2mutants. Shox2-mutant mice also display reduced exploratory activity, altered gait and impaired motor coordination. Our findings are the first to show a role for Shox2 in brain development. We provide evidence that Shox2 plays an important role during cerebellar development, perhaps to maintain the proper balance of Shh and Bmp expression levels in the dorsal vermis, and demonstrate that in the absence of Shox2, mice display both cerebellar impairments and deficits in motor coordination, ultimately highlighting the importance of Shox2 in the cerebellum.

  20. [Status of research and development for control of tropical diseases: hypocrisy, indifference or lack of coordination].

    PubMed

    Millet, P

    2006-12-01

    Tropical diseases neglected by the pharmaceutical industry usually involve developing countries. Neglected diseases can now be divided into two groups. The first includes the big three infections i.e., malaria, HIV/AIDS, and tuberculosis, that present strategic and political overtones. The second group includes a host of other fatal infections including worms, trypanosomiasis, and leishmaniasis. Fundamental research on neglected diseases has been highly productive, but there has been little success in transferring research findings to a pharmaceutical industry unwilling to take the risks associated with developing new drugs on its own. However several public-private initiatives have revived hopes of developing new products with growing involvement of industries in developing countries (India and Brazil) despite the high risks associated with fluctuating demand for medicines or funding shortages. To meet the need for testing new drugs, more clinical facilities and better patient recruitment will be needed in endemic countries. Although these new efforts to control neglected diseases are encouraging, there is now a need for coordination. Clinical research in developing countries must be organized in compliance with international principles of ethics. Testing must be aimed at validating fundamental data from industrialized countries. Appropriate incentives must be given to ensure that pharmaceutical companies use research findings for new product development. In this context, the time seems ripe for the establishment of an independent laboratory for technological innovation in neglected diseases. Such a facility could not only validate scientific data but also supervise the development of clinical applications from research data.

  1. [Status of research and development for control of tropical diseases: hypocrisy, indifference or lack of coordination].

    PubMed

    Millet, P

    2006-12-01

    Tropical diseases neglected by the pharmaceutical industry usually involve developing countries. Neglected diseases can now be divided into two groups. The first includes the big three infections i.e., malaria, HIV/AIDS, and tuberculosis, that present strategic and political overtones. The second group includes a host of other fatal infections including worms, trypanosomiasis, and leishmaniasis. Fundamental research on neglected diseases has been highly productive, but there has been little success in transferring research findings to a pharmaceutical industry unwilling to take the risks associated with developing new drugs on its own. However several public-private initiatives have revived hopes of developing new products with growing involvement of industries in developing countries (India and Brazil) despite the high risks associated with fluctuating demand for medicines or funding shortages. To meet the need for testing new drugs, more clinical facilities and better patient recruitment will be needed in endemic countries. Although these new efforts to control neglected diseases are encouraging, there is now a need for coordination. Clinical research in developing countries must be organized in compliance with international principles of ethics. Testing must be aimed at validating fundamental data from industrialized countries. Appropriate incentives must be given to ensure that pharmaceutical companies use research findings for new product development. In this context, the time seems ripe for the establishment of an independent laboratory for technological innovation in neglected diseases. Such a facility could not only validate scientific data but also supervise the development of clinical applications from research data. PMID:17286017

  2. Does the coordination of verbal and motor information explain the development of counting in children?

    PubMed

    Camos, V; Barrouillet, P; Fayol, M

    2001-03-01

    Counting is often considered to be the coordination of two actions: saying the number-words and pointing to each object. We report three experiments to test the hypothesis that this coordination requires the use of the central executive (A. D. Baddeley, 1990), and that the cost of coordination decreases with age. Participants were 5- and 9-year-old children and adults. At all ages tested, the manipulation of the difficulty of each component affected counting performance but did not make coordination more difficult. These results suggest that, at least from the age 5, counting is a procedure in which the control of coordination is not attention demanding. PMID:11222001

  3. Development of a body condition scoring index for female African elephants validated by ultrasound measurements of subcutaneous fat.

    PubMed

    Morfeld, Kari A; Lehnhardt, John; Alligood, Christina; Bolling, Jeff; Brown, Janine L

    2014-01-01

    Obesity-related health and reproductive problems may be contributing to non-sustainability of zoo African elephant (Loxodonta africana) populations. However, a major constraint in screening for obesity in elephants is lack of a practical method to accurately assess body fat. Body condition scoring (BCS) is the assessment of subcutaneous fat stores based on visual evaluation and provides an immediate appraisal of the degree of obesity of an individual. The objective of this study was to develop a visual BCS index for female African elephants and validate it using ultrasound measures of subcutaneous fat. To develop the index, standardized photographs were collected from zoo (n = 50) and free-ranging (n = 57) female African elephants for identifying key body regions and skeletal features, which were then used to visually determine body fat deposition patterns. This information was used to develop a visual BCS method consisting of a list of body regions and the physical criteria for assigning an overall score on a 5-point scale, with 1 representing the lowest and 5 representing the highest levels of body fat. Results showed that as BCS increased, ultrasound measures of subcutaneous fat thickness also increased (P<0.01), indicating the scores closely coincide with physical measures of fat reserves. The BCS index proved to be reliable and repeatable based on high intra- and inter-assessor agreement across three assessors. In comparing photographs of wild vs. captive African elephants, the median BCS in the free-ranging individuals (BCS = 3, range 1-5) was lower (P<0.001) than that of the zoo population (BCS = 4, range 2-5). In sum, we have developed the first validated BCS index for African elephants. This tool can be used to examine which factors impact body condition in zoo and free-ranging elephants, providing valuable information on how it affects health and reproductive potential of individual elephants.

  4. Fat-Dachsous Signaling Coordinates Cartilage Differentiation and Polarity during Craniofacial Development

    PubMed Central

    Le Pabic, Pierre; Ng, Carrie; Schilling, Thomas F.

    2014-01-01

    Organogenesis requires coordinated regulation of cellular differentiation and morphogenesis. Cartilage cells in the vertebrate skeleton form polarized stacks, which drive the elongation and shaping of skeletal primordia. Here we show that an atypical cadherin, Fat3, and its partner Dachsous-2 (Dchs2), control polarized cell-cell intercalation of cartilage precursors during craniofacial development. In zebrafish embryos deficient in Fat3 or Dchs2, chondrocytes fail to stack and misregulate expression of sox9a. Similar morphogenetic defects occur in rerea/atr2a −/− mutants, and Fat3 binds REREa, consistent with a model in which Fat3, Dchs2 and REREa interact to control polarized cell-cell intercalation and simultaneously control differentiation through Sox9. Chimaeric analyses support such a model, and reveal long-range influences of all three factors, consistent with the activation of a secondary signal that regulates polarized cell-cell intercalation. This coordinates the spatial and temporal morphogenesis of chondrocytes to shape skeletal primordia and defects in these processes underlie human skeletal malformations. Similar links between cell polarity and differentiation mechanisms are also likely to control organ formation in other contexts. PMID:25340762

  5. Monitoring and Evaluation of African Women in Agricultural Research and Development (AWARD): An Exemplar of Managing for Impact in Development Evaluation

    ERIC Educational Resources Information Center

    Brandon, Paul R.; Smith, Nick L.; Ofir, Zenda; Noordeloos, Marco

    2014-01-01

    In this Exemplars case, the fifth and final under the direction of the current coeditors, the authors present a reflective account of an ongoing, complex, multiyear, multinational monitoring and evaluation (M&E) system conducted for African Women in Agricultural Research and Development (AWARD), an international development program. The…

  6. Using the health belief model to develop culturally appropriate weight-management materials for African-American women.

    PubMed

    James, Delores C S; Pobee, Joseph W; Oxidine, D'lauren; Brown, Latonya; Joshi, Gungeet

    2012-05-01

    African-American women have the highest prevalence of adult obesity in the United States. They are less likely to participate in weight-loss programs and tend to have a low success rate when they do so. The goal of this project was to explore the use of the Health Belief Model in developing culturally appropriate weight-management programs for African-American women. Seven focus groups were conducted with 50 African-American women. The Health Belief Model was used as the study's theoretical framework. Participants made a clear delineation between the terms healthy weight, overweight, and obese. Sexy, flirtatious words, such as thick, stacked, and curvy were often used to describe their extra weight. Participants accurately described the health risks of obesity. Most believed that culture and genetics made them more susceptible to obesity. The perceived benefits of losing weight included reduced risk for health problems, improved physical appearance, and living life to the fullest. Perceived barriers included a lack of motivation, reliable dieting information, and social support. Motivators to lose weight included being diagnosed with a health problem, physical appearance, and saving money on clothes. Self-efficacy was primarily affected by a frustrated history of dieting. The data themes suggest areas that should be addressed when developing culturally appropriate weight-loss messages, programs, and materials for African-American women. PMID:22709771

  7. Microsatellite development and flow cytometry in the African tree genus Afzelia (Fabaceae, Caesalpinioideae) reveal a polyploid complex1

    PubMed Central

    Donkpegan, Armel S. L.; Doucet, Jean-Louis; Dainou, Kasso; Hardy, Olivier J.

    2015-01-01

    • Premise of the study: Microsatellites were developed in the vulnerable African rainforest tree Afzelia bipindensis to investigate gene flow patterns. • Methods and Results: Using 454 GS-FLX technique, 16 primer sets were identified and optimized, leading to 11 polymorphic and readable markers displaying each six to 25 alleles in a population. Up to four alleles per individual were found in each of the loci, without evidence of fixed heterozygosity, suggesting an autotetraploid genome. Cross-amplification succeeded for all loci in the African rainforest species A. pachyloba and A. bella, which appeared tetraploid, and for most loci in the African woodland species A. africana and A. quanzensis, which appeared diploid, but failed in the Asian species A. xylocarpa. Flow cytometry confirmed the suspected differences in ploidy. • Conclusions: African Afzelia species are diploid or tetraploid, a situation rarely documented in tropical trees. These newly developed microsatellites will help in the study of their mating system and gene flow patterns. PMID:25606356

  8. Development of a nanoparticulate formulation of diminazene to treat African trypanosomiasis

    NASA Astrophysics Data System (ADS)

    Kroubi, Maya; Daulouede, Sylvie; Karembe, Hamadi; Jallouli, Youssef; Howsam, Mike; Mossalayi, Djavad; Vincendeau, Philippe; Betbeder, Didier

    2010-12-01

    There is a real need to develop new therapeutic strategies for African trypanosomiasis infections. In our study, we developed a new drug delivery system of diminazene (DMZ), a trypanocidal drug registered for veterinary use. This drug candidate presents a limited efficacy, a poor affinity for brain tissue and instability. The development of colloidal formulations based on a porous cationic nanoparticle with an oily core (70DGNP + ), has potentially two advantages: stabilization of the drug and potential targeting of the parasite. We analyzed two processes of drug loading: in process (DMZ was added during the preparation of 70DGNP + at 80 °C) and post-loading (DMZ was mixed with a 70DGNP + solution at room temperature). Poor stability of the drug was observed using the in process technique. When using the post-loading technique over 80% drug entrapment efficiency was obtained at a ratio of DMZ:phospholipids (wt:wt) < 5%. Moreover, DMZ loaded into 70DGNP + was found to be protected against oxidation and was stable for at least six months at 4 °C. Finally, in vitro tests on T.b. brucei showed an increased efficacy of DMZ loaded in 70DGNP + .

  9. Temperature-independent energy expenditure in early development of the African clawed frog Xenopus laevis

    NASA Astrophysics Data System (ADS)

    Nagano, Yatsuhisa; Ode, Koji L.

    2014-08-01

    The thermal dissipation of activated eggs and embryos undergoing development from cleavage to the tailbud stage of the African clawed frog Xenopus laevis was measured as a function of incubation time at temperatures ranging from T = 288.2 K to 295.2 K, using a high-precision isothermal calorimeter. A23187-mediated activation of mature eggs induced stable periodic thermal oscillations lasting for 8-34 h. The frequency agreed well with the cell cycle frequency of initial cleavages at the identical temperature. In the developing embryo, energy metabolism switches from embryonic to adult features during gastrulation. The thermal dissipation after gastrulation fit well with a single modified Avrami equation, which has been used for modeling crystal-growth. Both the oscillation frequency of the activated egg and the growth rate of the embryo strongly depend on temperature with the same apparent activation energy of approximately 87 kJ mole-1. This result suggests that early development proceeds as a single biological time, attributable to a single metabolic rate. A temperature-independent growth curve was derived by scaling the thermogram to the biological time, indicating that the amount of energy expenditure during each developmental stage is constant over the optimal temperature range.

  10. Developing a reversible rapid coordinate transformation model for the cylindrical projection

    NASA Astrophysics Data System (ADS)

    Ye, Si-jing; Yan, Tai-lai; Yue, Yan-li; Lin, Wei-yan; Li, Lin; Yao, Xiao-chuang; Mu, Qin-yun; Li, Yong-qin; Zhu, De-hai

    2016-04-01

    Numerical models are widely used for coordinate transformations. However, in most numerical models, polynomials are generated to approximate "true" geographic coordinates or plane coordinates, and one polynomial is hard to make simultaneously appropriate for both forward and inverse transformations. As there is a transformation rule between geographic coordinates and plane coordinates, how accurate and efficient is the calculation of the coordinate transformation if we construct polynomials to approximate the transformation rule instead of "true" coordinates? In addition, is it preferable to compare models using such polynomials with traditional numerical models with even higher exponents? Focusing on cylindrical projection, this paper reports on a grid-based rapid numerical transformation model - a linear rule approximation model (LRA-model) that constructs linear polynomials to approximate the transformation rule and uses a graticule to alleviate error propagation. Our experiments on cylindrical projection transformation between the WGS 84 Geographic Coordinate System (EPSG 4326) and the WGS 84 UTM ZONE 50N Plane Coordinate System (EPSG 32650) with simulated data demonstrate that the LRA-model exhibits high efficiency, high accuracy, and high stability; is simple and easy to use for both forward and inverse transformations; and can be applied to the transformation of a large amount of data with a requirement of high calculation efficiency. Furthermore, the LRA-model exhibits advantages in terms of calculation efficiency, accuracy and stability for coordinate transformations, compared to the widely used hyperbolic transformation model.

  11. Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor.

    PubMed

    Peng, Tien; Tian, Ying; Boogerd, Cornelis J; Lu, Min Min; Kadzik, Rachel S; Stewart, Kathleen M; Evans, Sylvia M; Morrisey, Edward E

    2013-08-29

    Co-development of the cardiovascular and pulmonary systems is a recent evolutionary adaption to terrestrial life that couples cardiac output with the gas exchange function of the lung. Here we show that the murine pulmonary vasculature develops even in the absence of lung development. We have identified a population of multipotent cardiopulmonary mesoderm progenitors (CPPs) within the posterior pole of the heart that are marked by the expression of Wnt2, Gli1 and Isl1. We show that CPPs arise from cardiac progenitors before lung development. Lineage tracing and clonal analysis demonstrates that CPPs generate the mesoderm lineages within the cardiac inflow tract and lung including cardiomyocytes, pulmonary vascular and airway smooth muscle, proximal vascular endothelium, and pericyte-like cells. CPPs are regulated by hedgehog expression from the foregut endoderm, which is required for connection of the pulmonary vasculature to the heart. Together, these studies identify a novel population of multipotent cardiopulmonary progenitors that coordinates heart and lung co-development that is required for adaptation to terrestrial existence.

  12. Development of multiplex serological assay for the detection of human African trypanosomiasis.

    PubMed

    Nzou, Samson Muuo; Fujii, Yoshito; Miura, Masashi; Mwau, Matilu; Mwangi, Anne Wanjiru; Itoh, Makoto; Salam, Md Abdus; Hamano, Shinjiro; Hirayama, Kenji; Kaneko, Satoshi

    2016-04-01

    Human African trypanosomiasis (HAT) is a disease caused by Kinetoplastid infection. Serological tests are useful for epidemiological surveillance. The aim of this study was to develop a multiplex serological assay for HAT to assess the diagnostic value of selected HAT antigens for sero-epidemiological surveillance. We cloned loci encoding eight antigens from Trypanosoma brucei gambiense, expressed the genes in bacterial systems, and purified the resulting proteins. Antigens were subjected to Luminex multiplex assays using sera from HAT and VL patients to assess the antigens' immunodiagnostic potential. Among T. b. gambiense antigens, the 64-kDa and 65-kDa invariant surface glycoproteins (ISGs) and flagellar calcium binding protein (FCaBP) had high sensitivity for sera from T. b. gambiense patients, yielding AUC values of 0.871, 0.737 and 0.858 respectively in receiver operating characteristics (ROC) analysis. The ISG64, ISG65, and FCaBP antigens were partially cross-reactive to sera from Trypanosoma brucei rhodesiense patients. The GM6 antigen was cross-reactive to sera from T. b. rhodesiense patients as well as to sera from VL patients. Furthermore, heterogeneous antibody responses to each individual HAT antigen were observed. Testing for multiple HAT antigens in the same panel allowed specific and sensitive detection. Our results demonstrate the utility of applying multiplex assays for development and evaluation of HAT antigens for use in sero-epidemiological surveillance.

  13. Understanding global health and development partnerships: Perspectives from African and global health system professionals.

    PubMed

    Barnes, Amy; Brown, Garrett W; Harman, Sophie

    2016-06-01

    Partnership is a key idea in current debates about global health and development assistance, yet little is known about what partnership means to those who are responsible for operationalising it or how it is experienced in practice. This is particularly the case in the context of African health systems. This paper explores how health professionals working in global health hubs and the health systems of South Africa, Tanzania and Zambia understand and experience partnership. Drawing on semi-structured interviews with 101 professionals based in each country, Washington DC and Geneva between October 2012 and June 2013, the paper makes four key arguments. First, partnership has a legitimating function in global health policy processes for international development institutions, government agencies and civil society organisations alike. Second, the practice of partnership generates idiosyncratic and complicated relationships that health professionals have to manage and navigate, often informally. Third, partnership is shaped by historical legacies, critical events, and independent consultants. Fourth, despite being an accepted part of global health policy, there is little shared understanding of what good partnership is meant to include or resemble in practice. Knowing more about the specific socio-cultural and political dynamics of partnership in different health system contexts is critical to equip health professionals with the skills to build the informal relations that are essential to effective partnership engagement. PMID:27155226

  14. Health inequalities: promoting policy changes in utilizing transformation development by empowering African American communities in reducing health disparities.

    PubMed

    Kennedy, Bernice Roberts

    2013-01-01

    Social inequalities in the United States resulted in negative health outcomes for the African Americans. Their stressful living conditions of poverty, discrimination, racism, abuse and rejection from American society contribute to their negative health outcomes. The lifestyles of African Americans have been influenced by poverty and prior injustices, which have molded their worldview of health and illness. Dr. Martin Luther King, national civil rights leader, brought about social change with much prayer; however, he went a step further with collective gatherings to include the power of non-violence massive public demonstrations. This paper is an analytical review of the literature addressing social inequalities impacting on health inequalities of African Americans resulting in health disparities. Policy changes are propose by implementing transformation development and community empowerment models as frameworks for community/public health nurses in guiding African American communities with addressing health disparities. These models empower members of the community to participate in a collaborative effort in making political and social changes to improve their overall health outcomes.

  15. Health inequalities: promoting policy changes in utilizing transformation development by empowering African American communities in reducing health disparities.

    PubMed

    Kennedy, Bernice Roberts

    2013-01-01

    Social inequalities in the United States resulted in negative health outcomes for the African Americans. Their stressful living conditions of poverty, discrimination, racism, abuse and rejection from American society contribute to their negative health outcomes. The lifestyles of African Americans have been influenced by poverty and prior injustices, which have molded their worldview of health and illness. Dr. Martin Luther King, national civil rights leader, brought about social change with much prayer; however, he went a step further with collective gatherings to include the power of non-violence massive public demonstrations. This paper is an analytical review of the literature addressing social inequalities impacting on health inequalities of African Americans resulting in health disparities. Policy changes are propose by implementing transformation development and community empowerment models as frameworks for community/public health nurses in guiding African American communities with addressing health disparities. These models empower members of the community to participate in a collaborative effort in making political and social changes to improve their overall health outcomes. PMID:24575590

  16. Implementing the millennium development food security goals Challenges of the southern African context

    NASA Astrophysics Data System (ADS)

    Love, David; Twomlow, Steve; Mupangwa, Walter; van der Zaag, Pieter; Gumbo, Bekithemba

    The Millennium Development Goals’ target to halve the proportion of people who suffer from hunger is extremely important in southern Africa, where food security has become increasingly problematic over the last 20 years. One “quick-win” proposal is replenishment of soil nutrients for smallholder farmers, through free or subsidised chemical fertilisers. Other proposals include appropriate irrigation technology, improved inputs and interventions targeted at women. Analysis of over 10 years of agro-hydrological and agro-economic studies from southern African show that a different approach is required to interventions proposed. There are sustainability problems with free chemical fertiliser due to transport costs and ancillary costs. Furthermore, recent studies in Zimbabwe and Mozambique show that significant increases in yield can only be obtained when soil fertility management is combined with good crop husbandry, e.g. timely planting and weeding. Ongoing replenishment of fertility would be dependent on a continued free or subsidised fertiliser supply, and transport system. Increasing access to irrigation will help, but is not the only solution and cannot reach even a majority of farmers. It has been determined that short dryspells are often the major cause of low yields in sub-Saharan Africa. Soil-water conservation approaches, e.g. winter weeding and conservation tillage, can reduce risk and increase yield. The following specific recommendations are made for urgent interventions to contribute sustainably to food security in southern Africa: (i) To increases access to fertiliser, consider development of strong input markets at end-user level. (ii) Intensification of technology transfer, focusing on capacity building for transfer of existing technologies and much closer collaboration between state and NGO sectors, agronomists and water engineers. (iii) Increasing the uptake of soil-water conservation methods, including conservation tillage and weeding, and

  17. The influence of cognitive development and perceived racial discrimination on the psychological well-being of African American youth.

    PubMed

    Seaton, Eleanor K

    2010-06-01

    The present study examined the influence of cognitive development in the relationship between multiple types of racial discrimination and psychological well-being. A sample of 322 African American adolescents (53% female), aged 13-18, completed measures of cognitive development, racial discrimination, self-esteem and depressive symptoms. Based on the cognitive development measure, youth were categorized as having pre-formal or formal reasoning abilities. The results indicate no significant differences in perceptions of individual, cultural or collective/institutional racism between pre-formal reasoning and formal reasoning adolescents. However, the results do suggest that perceptions of collective/institutional racism were more harmful for the self-esteem of pre-formal reasoning youth than the self-esteem of formal reasoning youth. The implications for the racial discrimination literature among African American adolescents are discussed.

  18. Solving Bernstein's problem: a proposal for the development of coordinated movement by selection.

    PubMed

    Sporns, O; Edelman, G M

    1993-08-01

    In recent years, many established concepts in the theory of human motor development have undergone profound change, and our knowledge has increased greatly. Nevertheless, some outstanding problems remain unsolved. A central problem concerns the redundancy of effective movements, first pointed out by N. A. Bernstein. The human motor system is mechanically complex and can make use of a large number of degrees of freedom. The controlled operation of such a system requires a reduction of mechanical redundancy, effectively by reducing the number of degrees of freedom. More recent work has shown that this problem is hard to solve explicitly by computing solutions to the equations of motion of the system. Equally challenging to traditional computational approaches is the fact the motor systems show remarkable adaptability and flexibility in the presence of changing biomechanical properties of motor organs during development and when faced with different environmental conditions or tasks. Solutions to these problems would have a large impact on a variety of issues in child development. In this article, we stress the importance of the somatic selection of neuronal groups in maps for the progressive transformation of a primary movement repertoire into a set of motor synergies and adaptive action patterns. We present results from computer simulations of a simple motor system that works according to such selectional principles. This approach suggests a provisional solution to Bernstein's problem and provides new parameters to guide experimental approaches to the development of sensorimotor coordination.

  19. Solving Bernstein's problem: a proposal for the development of coordinated movement by selection.

    PubMed

    Sporns, O; Edelman, G M

    1993-08-01

    In recent years, many established concepts in the theory of human motor development have undergone profound change, and our knowledge has increased greatly. Nevertheless, some outstanding problems remain unsolved. A central problem concerns the redundancy of effective movements, first pointed out by N. A. Bernstein. The human motor system is mechanically complex and can make use of a large number of degrees of freedom. The controlled operation of such a system requires a reduction of mechanical redundancy, effectively by reducing the number of degrees of freedom. More recent work has shown that this problem is hard to solve explicitly by computing solutions to the equations of motion of the system. Equally challenging to traditional computational approaches is the fact the motor systems show remarkable adaptability and flexibility in the presence of changing biomechanical properties of motor organs during development and when faced with different environmental conditions or tasks. Solutions to these problems would have a large impact on a variety of issues in child development. In this article, we stress the importance of the somatic selection of neuronal groups in maps for the progressive transformation of a primary movement repertoire into a set of motor synergies and adaptive action patterns. We present results from computer simulations of a simple motor system that works according to such selectional principles. This approach suggests a provisional solution to Bernstein's problem and provides new parameters to guide experimental approaches to the development of sensorimotor coordination. PMID:8404271

  20. Dendritic Cells Coordinate the Development and Homeostasis of Organ-Specific Regulatory T Cells.

    PubMed

    Leventhal, Daniel S; Gilmore, Dana C; Berger, Julian M; Nishi, Saki; Lee, Victoria; Malchow, Sven; Kline, Douglas E; Kline, Justin; Vander Griend, Donald J; Huang, Haochu; Socci, Nicholas D; Savage, Peter A

    2016-04-19

    Although antigen recognition mediated by the T cell receptor (TCR) influences many facets of Foxp3(+) regulatory T (Treg) cell biology, including development and function, the cell types that present antigen to Treg cells in vivo remain largely undefined. By tracking a clonal population of Aire-dependent, prostate-specific Treg cells in mice, we demonstrated an essential role for dendritic cells (DCs) in regulating organ-specific Treg cell biology. We have shown that the thymic development of prostate-specific Treg cells required antigen presentation by DCs. Moreover, Batf3-dependent CD8α(+) DCs were dispensable for the development of this clonotype and had negligible impact on the polyclonal Treg cell repertoire. In the periphery, CCR7-dependent migratory DCs coordinated the activation of organ-specific Treg cells in the prostate-draining lymph nodes. Our results demonstrate that the development and peripheral regulation of organ-specific Treg cells are dependent on antigen presentation by DCs, implicating DCs as key mediators of organ-specific immune tolerance.

  1. Ovary and Gametophyte Development Are Coordinately Regulated by Auxin and Ethylene following Pollination.

    PubMed

    Zhang, X. S.; O'Neill, S. D.

    1993-04-01

    The differentiation and development of ovules in orchid flowers are pollination dependent. To define the developmental signals and timing of critical events associated with ovule differentiation, we have examined factors that regulate the initial events in megasporogenesis and female gametophyte development and characterized its progression toward maturity and fertilization. Two days after pollination, ovary wall epidermal cells begin to elongate and form hair cells; this is the earliest visible morphological change, and it occurs at least 3 days prior to pollen germination, indicating that signals associated with pollination itself trigger these early events. The effects of inhibitors of ethylene biosynthesis on early morphological changes indicated that ethylene, in the presence of auxin, is required to initiate ovary development and, indirectly, subsequent ovule differentiation. Surprisingly, pollen germination and growth were also strongly inhibited by inhibitors of ethylene biosynthesis, indicating that male gametophyte development is also regulated by ethylene. Detailed characterization of the development of both the female and male gametophyte in pollinated orchid flowers indicated that pollen tubes entered the ovary and grew along the ovary wall for 10 to 35 days, at which time growth was arrested. Approximately 40 days after pollination, coincident with ovule differentiation as indicated by the presence of a single archesporial cell, the direction of pollen tube growth became redirected toward the ovule, suggesting a chemical signaling between the developing ovule and male gametophyte. Taken together, these results indicate that both auxin and ethylene contribute to the regulation of both ovary and ovule development and to the coordination of development of male and female gametophytes.

  2. Dental caries development among African-American children: results from a 4-year longitudinal study

    PubMed Central

    Lim, Sungwoo; Tellez, Marisol; Ismail, Amid I.

    2015-01-01

    Objective To examine dental caries development and caries risk factors among preschool African-American children from low-income families in Detroit, Michigan over a four- year window. Methods Data came from a representative sample of 1,021 children (zero to five years) and their caregivers in Detroit. The baseline participants in 2002–03 (W1) were reexamined in 2004–05 (W2) and 2007 (W3). Caries was measured using the International Caries Detection and Assessment System. Bivariate and multivariate analyses for repeated data were conducted to explore associations between caries increment outcomes and demographics, access to dental care, oral health-related behaviors, and social and physical environments. Results The mean number of new NCCL (non-cavitated caries lesions) was 2.8 between W1 and W2 and 2.6 between W2 and W3, while the mean number of new CCL (cavitated caries lesions) was 2.0 and 2.0, respectively, during the same time periods. In younger children (< three years old in W1) higher number of new NCCL than new CCL were observed in both W1–W2 and W2–W3. The risk of new NCCL was associated with child’s soda intake and caregiver’s age. For the risk of new CCL, significant risk factors included baseline NCCL, baseline CCL, as well as child’s age. Baseline caries and child’s soda intake were also associated with the risk of developing new decayed, missing, and filled tooth surfaces. Conclusions Higher number of new NCCL relative to CCL was developed among low-income Africa-American children during early childhood. New caries development was associated with baseline caries and child’s soda intake. PMID:25441657

  3. Reproduction, larval growth, and reproductive development in African clawed frogs (Xenopus laevis) exposed to atrazine.

    PubMed

    Du Preez, Louis H; Kunene, Nisile; Everson, Gideon J; Carr, James A; Giesy, John P; Gross, Timothy S; Hosmer, Alan J; Kendall, Ronald J; Smith, Ernest E; Solomon, Keith R; Van Der Kraak, Glen J

    2008-03-01

    Reproductive success and development of F2 offspring from F1 adult African clawed frogs (Xenopus laevis) exposed to atrazine throughout larval development and as sexually mature adults was examined. Larval X. laevis were exposed to one of four nominal concentrations of atrazine (0, 1, 10, 25 microg atrazine/l) beginning 96 hr after fertilization and continuing through two years post-metamorphosis. Clutch size and survival of offspring were used as measurement endpoints to gauge reproductive success of the F1 frogs. Larval survivorship and time to metamorphosis were used to gauge developmental success of the F2 offspring from atrazine-exposed frogs. Testes in F1 and F2 frogs were examined for incidence of anomalies, such as testicular ovarian follicles, and sex ratios in F2 offspring were investigated to determine if exposure to atrazine caused trans-generational effects (effects on F2 individuals due to exposure of F1 individuals). There were no effects of any of the studied concentrations of atrazine on clutch size of F1 frogs. There were also no effects on hatching success or time to metamorphosis. Sex ratios did not differ between F2 offspring among treatments. There was no evidence to suggest a transgenerational effect of atrazine on spawning success or reproductive development of X. laevis. This is consistent with the presence of robust populations of X. laevis in areas where they are exposed to atrazine that has been used for several decades for weed control in production of corn. Our observations also are consistent with the results of most other studies of frogs where no effects were found to be associated with exposure to atrazine. Our data do not support the hypothesis that atrazine significantly affects reproductive fitness and development of frogs.

  4. Professional development and poststructural analysis: Stories of African-American science teachers

    NASA Astrophysics Data System (ADS)

    Moore, Felicia Michelle

    2003-10-01

    This interpretivist study focused on the professional development of three African American science teachers from a small rural school district, Carver School District (pseudonym), in the southeastern United States. Stories teachers shared of their experiences in teaching and learning science and in their professional development were analyzed using a feminist poststructural analysis of power, knowledge/meaning, language, and difference. For science teaching, power was viewed as a form of ownership or possession and also as effect and processes that impact teaching, learning, and professional development. Teachers through instructional practices exerted a certain amount of power in their classrooms. Teaching practices heavily influenced student learning in science classrooms. For teacher professional development, power was viewed as effecting relationships between administration, peers, and students as a shifting force within different social contexts. Science teachers were perceived as objects of the system and as active social agents who in particular relations of power acted in their best interests as they developed as science teachers. Teachers negotiated for themselves certain power relations to do as they wished for teaching science and for participating in teacher professional development activities. Power was an inherent and critically important aspect in understanding what science teachers do in their classrooms, in teaching and learning science, and in developing as science teachers. Knowledge was closely tied to relations of power in that teachers acquired knowledge about themselves, their teaching of science, and their students from their past experiences and professional development activities. Through language, interactions between teachers and students enabled or disabled access to the culture of power via instructional practices. Language was implicated in teacher professional development as a powerful force for advancing or hindering teachers

  5. Recent Updates on Development of Drug Molecules for Human African Trypanosomiasis.

    PubMed

    Singh Grewal, Ajmer; Pandita, Deepti; Bhardwaj, Shashikant; Lather, Viney

    2016-01-01

    Human African trypanosomiasis (HAT, better called as sleeping sickness), caused by two morphologically identicalprotozoan parasite Trypanosoma bruceiis transmitted by the bite of tsetse flies of Glossinagenus, mainly in the rural areas of the sub-Saharan Africa. HAT is one of the neglected tropical diseases and is characterized by sleep disturbance as the main symptom, hence is called as sleeping sickness. As it is epidemic in the poorest population of Africa, there is limited availability of safe and cost-effective tools for controlling the disease. Trypanosoma bruceigambiense causes sleeping sickness in Western and Central Africa, whereas Trypanosoma bruceirhodesiense is the reason for prevalence of sleeping sickness in Eastern and Southern Africa. For the treatment of sleeping sickness, only five drugs have been approved suramin, pentamidine, melarsoprol, eflornithine and nifurtimox. Various small molecules of diverse chemical nature have been synthesized for targeting HAT and many of them are in the clinical trialsincluding fexinidazole (phase I completed) and SCYX-7158 (advanced in phase I). The present work has been planned to review various types of small molecules developed in the last 10 years having potent antitrypanosoma activity likely to be beneficial in sleeping sickness along with different natural anti-HAT agents. PMID:27072715

  6. EuCARD 2010: European coordination of accelerator research and development

    NASA Astrophysics Data System (ADS)

    Romaniuk, Ryszard S.

    2010-09-01

    Accelerators are basic tools of the experimental physics of elementary particles, nuclear physics, light sources of the fourth generation. They are also used in myriad other applications in research, industry and medicine. For example, there are intensely developed transmutation techniques for nuclear waste from nuclear power and atomic industries. The European Union invests in the development of accelerator infrastructures inside the framework programs to build the European Research Area. The aim is to build new accelerator research infrastructures, develop the existing ones, and generally make the infrastructures more available to competent users. The paper summarizes the first year of activities of the EU FP7 Project Capacities EuCARD -European Coordination of Accelerator R&D. EuCARD is a common venture of 37 European Accelerator Laboratories, Institutes, Universities and Industrial Partners involved in accelerator sciences and technologies. The project, initiated by ESGARD, is an Integrating Activity co-funded by the European Commission under Framework Program 7 - Capacities for a duration of four years, starting April 1st, 2009. Several teams from this country participate actively in this project. The contribution from Polish research teams concerns: photonic and electronic measurement - control systems, RF-gun co-design, thin-film superconducting technology, superconducting transport infrastructures, photon and particle beam measurements and control.

  7. Coordination of Plastid and Light Signaling Pathways upon Development of Arabidopsis Leaves under Various Photoperiods

    PubMed Central

    Lepistö, Anna; Rintamäki, Eevi

    2012-01-01

    Plants synchronize their cellular and physiological functions according to the photoperiod (the length of the light period) in the cycle of 24 h. Photoperiod adjusts several traits in the plant life cycle, including flowering and senescence in annuals and seasonal growth cessation in perennials. Photoperiodic development is controlled by the coordinated action of photoreceptors and the circadian clock. During the past 10 years, remarkable progress has been made in understanding the molecular mechanism of the circadian clock, especially with regard to the transition of Arabidopsis from the vegetative growth to the reproductive phase. Besides flowering photoperiod also modifies plant photosynthetic structures and traits. Light signals controlling biogenesis of chloroplasts and development of leaf photosynthetic structures are perceived both by photoreceptors and in chloroplasts. In this review, we provide evidence suggesting that the photoperiodic development of Arabidopsis leaves mimics the acclimation of plant to various light intensities. Furthermore, the chloroplast-to-nucleus retrograde signals that adjust acclimation to light intensity are proposed to contribute also to the signaling pathways that control photoperiodic acclimation of leaves. PMID:22199239

  8. Developmental and ethnic issues experienced by emerging adult African American women related to developing a mature love relationship.

    PubMed

    Tyson, Sheryl Y

    2012-01-01

    This qualitative study explored perspectives of emerging adult African American women on the development of mature love relationships. Inductive analysis of focus group interviews, conducted with a purposive sample of 31 African American women, yielded themes related to relationship goals and characteristics, and interpersonal and societal challenges to finding the right partner and developing a mature love relationship. Core categories that emerged from analysis of the discussions were (1) age and relationship goal differences within the emerging adult group, (2) mature love relationship goals and characteristics, (3) interpersonal obstacles to finding the right partner, and (4) societal obstacles to finding the right partner. Two approaches-black womanist/feminist thought (Collins, 2000 ; Walker, 1983 ) and relationship maturity theory (Paul & White, 1990 )-were then combined to explain the influence of historic and contemporary interpersonal and societal factors on developmental and ethnic issues that challenge positive gender identity formation, hasten intimacy maturity, and hinder the development of mature love relationships among emerging adult African American women. For these women, premature responsibility, especially early caregiver burden, was related to the early development of intimacy capacity and the desire for a mature love relationship, to be protected, and to have someone to help carry the load. Interracial dating, negative stereotypic images of African American women, and even positive images of enduring black love relationships posed difficult challenges to positive identity formation and intimacy maturity. A primary challenge was to counteract negative stereotypic images, so that they could develop their own self-identities as women and as relationship partners. PMID:22224965

  9. Effect of water hardness on oocyte quality and embryo development in the African clawed frog (Xenopus laevis).

    PubMed

    Godfrey, Earl W; Sanders, George E

    2004-04-01

    Husbandry and health of the African clawed frog, Xenopus laevis, greatly influences the quality of oocytes produced. One factor affecting oocyte quality is the water conditions in which females are maintained. Dechlorination and adequate salt concentration are known to affect oocytes, but water hardness has not been considered an important factor in Xenopus husbandry by the research community. We found that, when females were kept in soft water or water with marine salts alone, even when it was cooled to 17 to 18 degrees C, the quality of oocytes decreased; only 20 to 25% of resulting embryos developed to tailbud stages. Survival and normal development of embryos increased significantly within one month of addition to the laboratory housing water of salts that mimic conditions in African Rift Valley lakes. These salts greatly increased water hardness; development of embryos to tailbud stages remained high (50 to 70% on average) for more than a year after their addition to the water housing females. Water from South African ponds where X. laevis are collected, and from wells used by the major suppliers of X. laevis, also was moderately to very hard. Our results suggest that X. laevis is naturally adapted to hard water, and indicate that increasing general hardness during laboratory housing is more important for oocyte quality and embryo development than is increasing carbonate hardness (alkalinity) in the water used to house females.

  10. Development of a spiritually based educational program to increase colorectal cancer screening among African American men and women.

    PubMed

    Holt, Cheryl L; Roberts, Chastity; Scarinci, Isabel; Wiley, Shereta R; Eloubeidi, Mohamad; Crowther, Martha; Bolland, John; Litaker, Mark S; Southward, Vivian; Coughlin, Steven S

    2009-07-01

    This study describes the development of a spiritually based intervention to increase colorectal cancer screening through African American churches by framing the health message with spiritual themes and scripture. The intervention development phase consisted of ideas from an advisory panel and core content identified in focus groups. In the pilot-testing phase, prototypes of the intervention materials were tested for graphic appeal in additional focus groups, and content was tested for acceptability and comprehension in cognitive interviews. Participants preferred materials showing a variety of African Americans in real settings, bright color schemes, and an uplifting message emphasizing prevention and early detection. Spiritual themes such as stewardship over the body, being well to serve God, and using faith to overcome fear, were well received. The materials were then finalized for implementation and will be used by community health advisors to encourage screening. PMID:19657823

  11. What some African development plans say on population related issues in development.

    PubMed

    1983-01-01

    This discussion reviews what development plans say about population related issues in development in the countries of Botswana, Kenya, Lesotho, Senegal, Nigeria, Ivory Coast, Seychelles, Sierra Leone, Somalia Democratic Republic, Sudan, The United Republic of Cameroon, Tanzania, Zambia, and Zimbabwe. Botswana's 1970-73 development plan recognized the need to have fewer children who would be better fed, well clothed, properly housed, and better educated. The government set a target of population growth not to exceed 2.5% for the 1970-80 period. The government of Kenya has expressed much concern about population growth and is devoted to continuing and strengthening the official family planning program instituted in 1967. Lesotho's 1980-81 to 1984-85 development plan emphasizes the need to enhance the well-being of the rural population. The orientation of the health sector strategy is towards primary health care, health education, family planning, water supply, sanitation, and nutrition. Nigeria's 1975-80 plan indicates that demographic factors do not appear as yet to constitute a significant or serious obstacle to domestic economic progress. The objective of the Ivory Coast's 1976-80 plan for economic, social, and cultural development is to increase population since the Ivory Coast still seems to be an underpopulated country. The 1979-83 National Development Plan of Seychelles includes the following objectives: to remedy the housing problem, to achieve full employment, and to introduce responsible family planning. Sierra Leone's development plan for 1974-75 to 1978-79 did not indicate a need to decrease population growth. Population variables in relation to development are not well articulated in the plan of the Somalia Democratic Republic. Like many other developing countries, Sudan's plan has objectives to improve all aspects of the standard of living. It recognizes the serious problem of absorbing a larger population in urban areas. In Tanzania family planning is

  12. Coordinator's Handbook. Research & Development Series No. 119-B. Career Planning Support System.

    ERIC Educational Resources Information Center

    Lowry, Cheryl Meredith; And Others

    This coordinator's handbook, one of a set of twelve documents describing the Career Planning Support System (CPSS) and its use, is designed as a project management tool and provides step-by-step procedures for planning, leading, and coordinating CPSS activities. (CPSS is a comprehensive guidance program management system which offers the school…

  13. The Development and Standardization of the Adult Developmental Co-Ordination Disorders/Dyspraxia Checklist (ADC)

    ERIC Educational Resources Information Center

    Kirby, Amanda; Edwards, Lisa; Sugden, David; Rosenblum, Sara

    2010-01-01

    Developmental Co-ordination Disorder (DCD), also known as Dyspraxia in the United Kingdom (U.K.), is a developmental disorder affecting motor co-ordination. In the past this was regarded as a childhood disorder, however there is increasing evidence that a significant number of children will continue to have persistent difficulties into adulthood.…

  14. Coordinated regulation of apical hook development by gibberellins and ethylene in etiolated Arabidopsis seedlings

    PubMed Central

    An, Fengying; Zhang, Xing; Zhu, Ziqiang; Ji, Yusi; He, Wenrong; Jiang, Zhiqiang; Li, Mingzhe; Guo, Hongwei

    2012-01-01

    Dark-grown Arabidopsis seedlings develop an apical hook when germinating in soil, which protects the cotyledons and apical meristematic tissues when protruding through the soil. Several hormones are reported to distinctly modulate this process. Previous studies have shown that ethylene and gibberellins (GAs) coordinately regulate the hook development, although the underlying molecular mechanism is largely unknown. Here we showed that GA3 enhanced while paclobutrazol repressed ethylene- and EIN3-overexpression (EIN3ox)-induced hook curvature, and della mutant exhibited exaggerated hook curvature, which required an intact ethylene signaling pathway. Genetic study revealed that GA-enhanced hook development was dependent on HOOKLESS 1 (HLS1), a central regulator mediating the input of the multiple signaling pathways during apical hook development. We further found that GA3 induced (and DELLA proteins repressed) HLS1 expression in an ETHYLENE INSENSITIVE 3/EIN3-LIKE 1 (EIN3/EIL1)-dependent manner, whereby EIN3/EIL1 activated HLS1 transcription by directly binding to its promoter. Additionally, DELLA proteins were found to interact with the DNA-binding domains of EIN3/EIL1 and repress EIN3/EIL1-regulated HLS1 expression. Treatment with naphthylphthalamic acid, a polar auxin transport inhibitor, repressed the constitutively exaggerated hook curvature of EIN3ox line and della mutant, supporting that auxin functions downstream of the ethylene and GA pathways in hook development. Taken together, our results identify EIN3/EIL1 as a new class of DELLA-associated transcription factors and demonstrate that GA promotes apical hook formation in cooperation with ethylene partly by inducing the expression of HLS1 via derepression of EIN3/EIL1 functions. PMID:22349459

  15. Psychopathology, adversity, and creativity: diversifying experiences in the development of eminent African Americans.

    PubMed

    Damian, Rodica Ioana; Simonton, Dean Keith

    2015-04-01

    Symptoms associated with mental illness have been hypothesized to relate to creative achievement because they act as diversifying experiences. However, this theory has only been tested on predominantly majority-culture samples. Do tendencies toward mental illness still predict eminent creativity when they coexist with other diversifying experiences, such as early parental death, minority-status, or poverty? These alternative diversifying experiences can be collectively referred to as examples of developmental adversity. This conjecture was tested on a significant sample of 291 eminent African Americans who, by the nature of their status as long-term minorities, would experience more developmental adversity. Replicating majority-culture patterns, African American artists showed higher mental illness rates than African American scientists. Yet the absolute percentages were significantly lower for the African Americans, regardless of profession. Furthermore, mental illness predicted higher eminence levels only for the African American artists, an effect that diminished when controlling for developmental adversity. Because the latter predicted eminence for both artists and scientists, the "madness-to-genius" link probably represents just 1 of several routes by which diversifying experiences can influence eminence. The same developmental ends can be attained by different means. This inference warrants further research using other eminent creators emerging from minority culture populations.

  16. Co-ordinated brain and craniofacial development depend upon Patched1/XIAP regulation of cell survival.

    PubMed

    Aoto, Kazushi; Trainor, Paul A

    2015-02-01

    Congenital brain and craniofacial defects often occur together as a consequence of their developmental dependency on common progenitor tissue interactions and signaling pathways during embryogenesis. A classic example of this is perturbation of midline embryo development, and disruption of Hedgehog (Hh) signaling in the pathogenesis of holoprosencephaly. However, our understanding of how Hh signaling governs cell and tissue survival remains incomplete. Patched1 (Ptch1) is a well-known receptor for Hh ligands and Ptch1 overexpression is associated with cell and tissue-specific apoptosis. Here, we demonstrate that the X-linked inhibitory apoptosis protein (XIAP) associates with the C terminus of Ptch1 (Ptch1-C) in primary cilia to inhibit Ptch1-mediated cell death. Consistent with this observation, inhibition of XIAP suppresses cell proliferation, resulting in cell death and pathogenesis of an Hh loss-of-function phenotype. Thus, co-ordinated development of the brain and face is dependent in part upon XIAP mediation of Hh/Ptch1-regulated cell survival and apoptosis during embryogenesis. PMID:25292199

  17. Meis1 coordinates a network of genes implicated in eye development and microphthalmia.

    PubMed

    Marcos, Séverine; González-Lázaro, Monica; Beccari, Leonardo; Carramolino, Laura; Martin-Bermejo, Maria Jesus; Amarie, Oana; Mateos-San Martín, Daniel; Torroja, Carlos; Bogdanović, Ozren; Doohan, Roisin; Puk, Oliver; Hrabě de Angelis, Martin; Graw, Jochen; Gomez-Skarmeta, Jose Luis; Casares, Fernando; Torres, Miguel; Bovolenta, Paola

    2015-09-01

    Microphthalmos is a rare congenital anomaly characterized by reduced eye size and visual deficits of variable degree. Sporadic and hereditary microphthalmos have been associated with heterozygous mutations in genes fundamental for eye development. Yet, many cases are idiopathic or await the identification of molecular causes. Here we show that haploinsufficiency of Meis1, which encodes a transcription factor with evolutionarily conserved expression in the embryonic trunk, brain and sensory organs, including the eye, causes microphthalmic traits and visual impairment in adult mice. By combining analysis of Meis1 loss-of-function and conditional Meis1 functional rescue with ChIP-seq and RNA-seq approaches we show that, in contrast to its preferential association with Hox-Pbx BSs in the trunk, Meis1 binds to Hox/Pbx-independent sites during optic cup development. In the eye primordium, Meis1 coordinates, in a dose-dependent manner, retinal proliferation and differentiation by regulating genes responsible for human microphthalmia and components of the Notch signaling pathway. In addition, Meis1 is required for eye patterning by controlling a set of eye territory-specific transcription factors, so that in Meis1(-/-) embryos boundaries among the different eye territories are shifted or blurred. We propose that Meis1 is at the core of a genetic network implicated in eye patterning/microphthalmia, and represents an additional candidate for syndromic cases of these ocular malformations.

  18. Coordinated in-situ observation of developing hurricanes using atmospheric balloons - a Model Predictive Control approach

    NASA Astrophysics Data System (ADS)

    Meneghello, Gianluca; Bewley, Thomas

    2014-11-01

    Current operational methods used to monitor the development of hurricanes and typhoons include radar and satellite imagery as well as dropsondes parachuted from repeated aircraft flights above the hurricane itself. The accurate in-situ measurements provided by dropsondes are especially valuable for generating an accurate forecast of a hurricane's evolution and landfall. Unfortunately, the data from dropsondes is expensive to obtain (requiring many hazardous high-altitude flights) and limited both spatially (to the vertical profile of its path) and temporally (to the ten or twenty minutes it takes to fall). We show in the present work how receding-horizon MPC can be used to coordinate a formation of sensor-laden atmospheric balloons, distributing them quasi-uniformly across a realistic developing hurricane flowfield for days at a time. Several atmospheric balloons can be released from a high-altitude aircraft, or launched from a ship at sea level, and distributed over the hurricane thereafter. Certain target orbits of interest in the hurricane can be continuously sampled by some balloons, while other balloons make continuous sweeps between the eye and the spiral rain bands. Various solution methods for the optimal control problem arising within the MPC framework are considered.

  19. The TEA transcription factor Tec1 links TOR and MAPK pathways to coordinate yeast development.

    PubMed

    Brückner, Stefan; Kern, Sandra; Birke, Raphael; Saugar, Irene; Ulrich, Helle D; Mösch, Hans-Ulrich

    2011-10-01

    In Saccharomyces cerevisiae, the TEA transcription factor Tec1 controls several developmental programs in response to nutrients and pheromones. Tec1 is targeted by the pheromone-responsive Fus3/Kss1 mitogen-activated protein kinase (MAPK) cascade, which destabilizes the transcription factor to ensure efficient mating of sexual partner cells. The regulation of Tec1 by signaling pathways that control cell division and development in response to nutrients, however, is not known. Here, we show that Tec1 protein stability is under control of the nutrient-sensitive target of rapamycin complex 1 (TORC1) signaling pathway via the Tip41-Tap42-Sit4 branch. We further show that degradation of Tec1 upon inhibition of TORC1 by rapamycin does not involve polyubiquitylation and appears to be proteasome independent. However, rapamycin-induced Tec1 degradation depends on the HECT ubiquitin ligase Rsp5, which physically interacts with Tec1 via conserved PxY motives. We further demonstrate that rapamycin and mating pheromone control Tec1 protein stability through distinct mechanisms by targeting different domains of the transcription factor. Finally, we show that Tec1 is a positive regulator of yeast chronological lifespan (CLS), a known TORC1-regulated process. Our findings indicate that in yeast, Tec1 links TORC1 and MAPK signaling pathways to coordinate control of cellular development in response to different stimuli. PMID:21840851

  20. Weak Coordination as a Powerful Means for Developing Broadly Useful C–H Functionalization Reactions

    PubMed Central

    Engle, Keary M.; Mei, Tian-Sheng; Wasa, Masayuki

    2011-01-01

    functional group (or groups) can be used to chelate the metal catalyst and position it for selective C–H cleavage. Precoordination can overcome the paraffin nature of C–H bonds by increasing the effective concentration of the substrate so that it needn't be used as solvent. From a synthetic perspective, it is desirable to use a functional group that is an intrinsic part of the substrate so that extra steps for installation and removal of an external directing group can be avoided. In this way, dramatic increases in molecular complexity can be accomplished in a single stroke through stereo- and site-selective introduction of a new functional group. Although reactivity is a major challenge (as with first functionalization), the philosophy in further functionalization differs—the major challenge is developing reactions that work with predictable selectivity in intricately functionalized contexts on commonly occurring structural motifs. In this Account, we focus on an emergent theme within the further functionalization literature: the use of commonly occurring functional groups to direct C–H cleavage through weak coordinations. We discuss our motivation for studying Pd-catalyzed C–H functionalization assisted by weakly coordinating functional groups and chronicle our endeavors to bring reactions of this type to fruition. Through this approach, we have developed reactions with a diverse range of substrates and coupling partners, with the broad scope likely stemming from higher reactivity of the less stable cyclopalladated intermediates held in place by weak coordinations. PMID:22166158

  1. Development of an atmospheric model based on a generalized vertical coordinate. Final report, September 12, 1991--August 31, 1997

    SciTech Connect

    Arakawa, Akio; Konor, C.S.

    1997-12-31

    There are great conceptual advantages in the use of an isentropic vertical coordinate in atmospheric models. Design of such a model, however, requires to overcome computational problems due to intersection of coordinate surfaces with the earth`s surface. Under this project, the authors have completed the development of a model based on a generalized vertical coordinate, {zeta} = F({Theta}, p, p{sub s}), in which an isentropic coordinate can be combined with a terrain-following {sigma}-coordinate a smooth transition between the two. One of the key issues in developing such a model is to satisfy the consistency between the predictions of pressure and potential temperature. In the model, the consistency is satisfied by the use of an equation that determines the vertical mass flux. A procedure to properly choose {zeta} = F({Theta}, p, p{sub s}) is also developed, which guarantees that {zeta} is a monotonic function of height even when unstable stratification occurs. There are two versions of the model constructed in parallel: one is the middle-latitude {beta}-plane version and the other is the global version. Both of these versions include moisture prediction, relaxed large-scale condensation and relaxed moist-convective adjustment schemes. A well-mixed planetary boundary layer (PBL) is also added.

  2. Sequential and Coordinated Actions of c-Myc and N-Myc Control Appendicular Skeletal Development

    PubMed Central

    Ota, Sara; Akiyama, Haruhiko; Keene, Douglas R.; Hurlin, Peter J.

    2011-01-01

    Background During limb development, chondrocytes and osteoblasts emerge from condensations of limb bud mesenchyme. These cells then proliferate and differentiate in separate but adjacent compartments and function cooperatively to promote bone growth through the process of endochondral ossification. While many aspects of limb skeletal formation are understood, little is known about the mechanisms that link the development of undifferentiated limb bud mesenchyme with formation of the precartilaginous condensation and subsequent proliferative expansion of chondrocyte and osteoblast lineages. The aim of this study was to gain insight into these processes by examining the roles of c-Myc and N-Myc in morphogenesis of the limb skeleton. Methodology/Principal Findings To investigate c-Myc function in skeletal development, we characterized mice in which floxed c-Myc alleles were deleted in undifferentiated limb bud mesenchyme with Prx1-Cre, in chondro-osteoprogenitors with Sox9-Cre and in osteoblasts with Osx1-Cre. We show that c-Myc promotes the proliferative expansion of both chondrocytes and osteoblasts and as a consequence controls the process of endochondral growth and ossification and determines bone size. The control of proliferation by c-Myc was related to its effects on global gene transcription, as phosphorylation of the C-Terminal Domain (pCTD) of RNA Polymerase II, a marker of general transcription initiation, was tightly coupled to cell proliferation of growth plate chondrocytes where c-Myc is expressed and severely downregulated in the absence of c-Myc. Finally, we show that combined deletion of N-Myc and c-Myc in early limb bud mesenchyme gives rise to a severely hypoplastic limb skeleton that exhibits features characteristic of individual c-Myc and N-Myc mutants. Conclusions/Significance Our results show that N-Myc and c-Myc act sequentially during limb development to coordinate the expansion of key progenitor populations responsible for forming the limb

  3. Computer-developed construction of analytic expressions for the coordinates and partial derivatives of Jupiter's Galilean satellites

    NASA Technical Reports Server (NTRS)

    Lieske, J. H.

    1975-01-01

    A method for improving Sampson's (1910, 1912, 1921) original work in developing series expressions for accurate coordinates of the Galilean satellites is discussed. The method, which utilizes computer-based algebraic manipulation software, was developed to reconstruct Sampson's theory, remove existing errors, introduce neglected effects, and provide analytic expressions for the coordinates as well as for the partial derivatives with respect to orbital parameters, Jupiter's mass and oblateness, the satellite masses, and Jupiter's pole and rotation period. The software system, capable of handling Poisson series with up to 73 polynomial variables and 28 trigonometric arguments, is described. The preliminary solution is presented, and procedures are outlined for calculating perturbations and eliminating auxiliary parameters.

  4. Coordinated expression of H3K9 histone methyltransferases during tooth development in mice.

    PubMed

    Kamiunten, Taichi; Ideno, Hisashi; Shimada, Akemi; Nakamura, Yoshiki; Kimura, Hiroshi; Nakashima, Kazuhisa; Nifuji, Akira

    2015-03-01

    Tissue-specific gene expression is subjected to epigenetic and genetic regulation. Posttranslational modifications of histone tails alter the accessibility of nuclear proteins to DNA, thus affecting the activity of the regulatory complex of nuclear proteins. Methylation at histone 3 lysine 9 (H3K9) is a crucial modification that affects gene expression and cell differentiation. H3K9 is known to have 0-3 methylation states, and these four methylated states are determined by the expression of sets of histone methyltransferases. During development, teeth are formed through mutual interactions between the mesenchyme and epithelium via a process that is subjected to the epigenetic regulation. In this study, we examined the expression of all H3K9 methyltransferases (H3K9MTases) during mouse tooth development. We found that four H3K9MTases-G9a, Glp, Prdm2, and Suv39h1-were highly expressed in the tooth germ, with expression peaks at around embryonic days 16.5 and 17.5 in mice. Immunohistochemical and in situ hybridization analyses revealed that all four H3K9MTases were enriched in the mesenchyme more than in the epithelium. Substrates of H3K9MTases, H3K9me1, H3K9me2, and H3K9me3 were also enriched in the mesenchyme. Taken together, these data suggested that coordinated expression of four H3K9MTases in the dental mesenchyme might play important roles in tooth development.

  5. Mouse limb skeletal growth and synovial joint development are coordinately enhanced by Kartogenin

    PubMed Central

    Decker, Rebekah S.; Koyama, Eiki; Enomoto-Iwamoto, Motomi; Maye, Peter; Rowe, David; Zhu, Shoutian; Schultz, Peter G.; Pacifici, Maurizio

    2014-01-01

    Limb development requires the coordinated growth of several tissues and structures including long bones, joints and tendons, but the underlying mechanisms are not wholly clear. Recently, we identified a small drug-like molecule -we named Kartogenin (KGN)- that greatly stimulates chondrogenesis in marrow-derived mesenchymal stem cells (MSCs) and enhances cartilage repair in mouse osteoarthritis (OA) models. To determine whether limb developmental processes are regulated by KGN, we tested its activity on committed preskeletal mesenchymal cells from mouse embryo limb buds and whole limb explants. KGN did stimulate cartilage nodule formation and more strikingly, boosted digit cartilaginous anlaga elongation, synovial joint formation and interzone compaction, tendon maturation as monitored by ScxGFP, and interdigit invagination. To identify mechanisms, we carried out gene expression analyses and found that several genes, including those encoding key signaling proteins, were up-regulated by KGN. Amongst highly up-regulated genes were those encoding hedgehog and TGFβ superfamily members, particularly TFGβ1. The former response was verified by increases in Gli1-LacZ activity and Gli1 mRNA expression. Exogenous TGFβ1 stimulated cartilage nodule formation to levels similar to KGN, and KGN and TGFβ1 both greatly enhanced expression of lubricin/Prg4 in articular superficial zone cells. KGN also strongly increased the cellular levels of phospho-Smads that mediate canonical TGFβ and BMP signaling. Thus, limb development is potently and harmoniously stimulated by KGN. The growth effects of KGN appear to result from its ability to boost several key signaling pathways and in particular TGFβ signaling, working in addition to and/or in concert with the filamin A/CBFβ/RUNX1 pathway we identified previously to orchestrate overall limb development. KGN may thus represent a very powerful tool not only for OA therapy, but also limb regeneration and tissue repair strategies. PMID

  6. Path optimization by a variational reaction coordinate method. I. Development of formalism and algorithms

    SciTech Connect

    Birkholz, Adam B.; Schlegel, H. Bernhard

    2015-12-28

    The development of algorithms to optimize reaction pathways between reactants and products is an active area of study. Existing algorithms typically describe the path as a discrete series of images (chain of states) which are moved downhill toward the path, using various reparameterization schemes, constraints, or fictitious forces to maintain a uniform description of the reaction path. The Variational Reaction Coordinate (VRC) method is a novel approach that finds the reaction path by minimizing the variational reaction energy (VRE) of Quapp and Bofill. The VRE is the line integral of the gradient norm along a path between reactants and products and minimization of VRE has been shown to yield the steepest descent reaction path. In the VRC method, we represent the reaction path by a linear expansion in a set of continuous basis functions and find the optimized path by minimizing the VRE with respect to the linear expansion coefficients. Improved convergence is obtained by applying constraints to the spacing of the basis functions and coupling the minimization of the VRE to the minimization of one or more points along the path that correspond to intermediates and transition states. The VRC method is demonstrated by optimizing the reaction path for the Müller-Brown surface and by finding a reaction path passing through 5 transition states and 4 intermediates for a 10 atom Lennard-Jones cluster.

  7. Path optimization by a variational reaction coordinate method. I. Development of formalism and algorithms.

    PubMed

    Birkholz, Adam B; Schlegel, H Bernhard

    2015-12-28

    The development of algorithms to optimize reaction pathways between reactants and products is an active area of study. Existing algorithms typically describe the path as a discrete series of images (chain of states) which are moved downhill toward the path, using various reparameterization schemes, constraints, or fictitious forces to maintain a uniform description of the reaction path. The Variational Reaction Coordinate (VRC) method is a novel approach that finds the reaction path by minimizing the variational reaction energy (VRE) of Quapp and Bofill. The VRE is the line integral of the gradient norm along a path between reactants and products and minimization of VRE has been shown to yield the steepest descent reaction path. In the VRC method, we represent the reaction path by a linear expansion in a set of continuous basis functions and find the optimized path by minimizing the VRE with respect to the linear expansion coefficients. Improved convergence is obtained by applying constraints to the spacing of the basis functions and coupling the minimization of the VRE to the minimization of one or more points along the path that correspond to intermediates and transition states. The VRC method is demonstrated by optimizing the reaction path for the Müller-Brown surface and by finding a reaction path passing through 5 transition states and 4 intermediates for a 10 atom Lennard-Jones cluster.

  8. Coordinating progenitor cell cycle exit and differentiation in the developing vertebrate retina.

    PubMed

    Miles, Amanda; Tropepe, Vincent

    2016-01-01

    The proper development of the vertebrate retina relies heavily on producing the correct number and type of differentiated retinal cell types. To achieve this, proliferating retinal progenitor cells (RPCs) must exit the cell cycle at an appropriate time and correctly express a subset of differentiation markers that help specify retinal cell fate. Homeobox genes, which encode a family of transcription factors, have been accredited to both these processes, implicated in the transcriptional regulation of important cell cycle components, such as cyclins and cyclin-dependent kinases, and proneural genes. This dual regulation of homeobox genes allows these factors to help co-ordinate the transition from the proliferating RPC to postmitotic, differentiated cell. However, understanding the exact molecular targets of these factors remains a challenging task. This commentary highlights the current knowledge we have about how these factors regulate cell cycle progression and differentiation, with particular emphasis on a recent discovery from our lab demonstrating an antagonistic relationship between Vsx2 and Dmbx1 to control RPC proliferation. Future studies should aim to further understand the direct transcriptional targets of these genes, additional co-factors/interacting proteins and the possible recruitment of epigenetic machinery by these homeobox genes. PMID:27604453

  9. Path optimization by a variational reaction coordinate method. I. Development of formalism and algorithms

    NASA Astrophysics Data System (ADS)

    Birkholz, Adam B.; Schlegel, H. Bernhard

    2015-12-01

    The development of algorithms to optimize reaction pathways between reactants and products is an active area of study. Existing algorithms typically describe the path as a discrete series of images (chain of states) which are moved downhill toward the path, using various reparameterization schemes, constraints, or fictitious forces to maintain a uniform description of the reaction path. The Variational Reaction Coordinate (VRC) method is a novel approach that finds the reaction path by minimizing the variational reaction energy (VRE) of Quapp and Bofill. The VRE is the line integral of the gradient norm along a path between reactants and products and minimization of VRE has been shown to yield the steepest descent reaction path. In the VRC method, we represent the reaction path by a linear expansion in a set of continuous basis functions and find the optimized path by minimizing the VRE with respect to the linear expansion coefficients. Improved convergence is obtained by applying constraints to the spacing of the basis functions and coupling the minimization of the VRE to the minimization of one or more points along the path that correspond to intermediates and transition states. The VRC method is demonstrated by optimizing the reaction path for the Müller-Brown surface and by finding a reaction path passing through 5 transition states and 4 intermediates for a 10 atom Lennard-Jones cluster.

  10. Development of the fluid-type transport code on the flux coordinates in a tokamak

    NASA Astrophysics Data System (ADS)

    Honda, Mitsuru; Fukuyama, Atsushi

    2016-11-01

    The one-dimensional fluid-type transport code, TASK/TX, is developed compatible with the flux coordinates in a tokamak. Unlike diffusive transport equations usually adopted in conventional transport codes, the governing equations conform to a two-fluid model consisting of Maxwell's equations and the multiple fluid moment equations for each species.Quasi-neutrality and ambipolar flux conditions are not imposed, which are inherently satisfied as a consequence of the equation system solved. The neoclassical particle flux is not approximated by the flux-gradient relationship, and the total particle flux composed of the neoclassical and turbulent contributions is directly treated as the dependent variable. The quantities related to neoclassical transport are intrinsically calculated without external neoclassical transport modules. In other words, TASK/TX by itself has the function of a neoclassical transport solver based on the moment approach as well. Several numerical tests clearly reveal the unique features of TASK/TX not possessed by conventional transport codes.

  11. Communication and Development: African and Afro-American Parallels. Journalism Monographs, No. 28.

    ERIC Educational Resources Information Center

    Dodson, Don; Hachten, William A.

    The communication patterns among Africans and American blacks are rooted in similarities. Both groups are constricted within societal communication networks, with blacks occupying peripheral positions. Special cognitive and linguistic handicaps erect obstinate barriers to reforms in the distribution and reciprocity of power. The assertion of black…

  12. South African Teacher Voices: Recurring Resistances and Reconstructions for Teacher Education and Development

    ERIC Educational Resources Information Center

    Samuel, Michael

    2014-01-01

    This paper will focus on the shifts in discourses about teacher education and teacher voice within the South African research and policy environment over the last four decades. The alignment of the political and educational agenda in providing resistance to the apartheid system culminated in 1994, the start of the new democracy. The preceding…

  13. African American and Youth Culture as a Bridge To Writing Development. Final Report.

    ERIC Educational Resources Information Center

    Mahiri, Jabari

    A study examined whether the familiarity and competence that many African American students have with elements of rap music and culture could be used as a bridge to the production of other literate texts. Two high-school English teachers, one teaching at Fremont High School, East Oakland and the other teaching at Berkeley High School in Berkeley,…

  14. Male and Female: Career Development of African American College Athletes and Non-Athletes

    ERIC Educational Resources Information Center

    Alexander, Jamie Dowdy

    2015-01-01

    Tendency to foreclose on careers, vocational exploration, and career commitment were examined in relationship to racial-ethnic socialization, parental responsiveness, and career-related verbal encouragement and emotional support among 228 African American male and female college athletes and non-athletes. A number of tests were conducted to test…

  15. African Scientific Network: A model to enhance scientific research in developing countries

    NASA Astrophysics Data System (ADS)

    Kebede, Abebe

    2002-03-01

    Africa has over 350 higher education institutions with a variety of experiences and priorities. The primary objectives of these institutions are to produce white-collar workers, teachers, and the work force for mining, textiles, and agricultural industries. The state of higher education and scientific research in Africa have been discussed in several conferences. The proposals that are generated by these conferences advocate structural changes in higher education, North-South institutional linkages, mobilization of the African Diaspora and funding. We propose a model African Scientific Network that would facilitate and enhance international scientific partnerships between African scientists and their counterparts elsewhere. A recent article by James Lamout (Financial Times, August 2, 2001) indicates that emigration from South Africa alone costs $8.9 billion in lost human resources. The article also stated that every year 23,000 graduates leave Africa for opportunities overseas, mainly in Europe, leaving only 20,000 scientists and engineers serving over 600 million people. The International Organization for Migration states that the brain drain of highly skilled professionals from Africa is making economic growth and poverty alleviation impossible across the continent. In our model we will focus on a possible networking mechanism where the African Diaspora will play a major role in addressing the financial and human resources needs of higher education in Africa

  16. African American Culture and Physical Skill Development Programs: The Effect on Golf after Tiger Woods.

    ERIC Educational Resources Information Center

    Roberson, Venita

    2003-01-01

    Examines the root causes of the slow rate of change in how professional trainers in traditionally white mainstream athletics have approached the pedagogical aspect of their work. Many African Americans and Latinos are entering fields that were once traditionally white. Explores the nature of this asymmetrical relationship, discussing a culturally…

  17. The African University and the Challenge of Endogenous Development in Africa.

    ERIC Educational Resources Information Center

    Sherman, Mary Antoninette Brown

    This paper addresses the need of institutions located within Africa, particularly institutions of higher education, to fulfill the task of generating and applying knowledge relevant to solving the economic, food, and health problems that plague the continent. The paper examines the nature of African universities and the historical context in which…

  18. South African Rural Teachers' Reflections on Their Problems of Practice: Taking Modest Steps in Professional Development

    ERIC Educational Resources Information Center

    Bansilal, Sarah; Rosenberg, Thelma

    2011-01-01

    This article reports on a study that was conducted with 41 rural teachers drawn from a larger sample of 691 teachers who were enrolled for an in-service programme at a South African university. As part of the assessment of a research component of the programme, teachers were asked to report on how they designed and carried out an intervention to…

  19. Developing Self-Expression and Community among South African Women with Persona Doll Making

    ERIC Educational Resources Information Center

    Garcia, Dorothy Yumi

    2014-01-01

    Township-dwelling Black South African women must cope with an array of traumatizing stressors that stunt individual voice and diminish the creation of supportive female communities. At issue was the capacity of women under these conditions to thrive as individuals and contributing members of society, thus the rationale for this project study. The…

  20. The Development of an African-Centered Urban High School by Trial and Error

    ERIC Educational Resources Information Center

    Robinson, Theresa Y.; Jeremiah, Maxine

    2011-01-01

    As part of the Small Schools movement in Chicago Public Schools, a high school dedicated to African-centered education was chartered. The virtues of Ma'at and the Nguzo Saba, otherwise known as the seven principles of Kwanza, were the foundational principles of the school and were to be integrated into all of the practices and policies of the…

  1. Examining church capacity to develop and disseminate a religiously appropriate HIV tool kit with African American churches.

    PubMed

    Berkley-Patton, Jannette; Thompson, Carole Bowe; Martinez, David Alfonso; Hawes, Starlyn Montez; Moore, Erin; Williams, Eric; Wainright, Cassandra

    2013-06-01

    Increasingly, African American churches have been called upon to assist in efforts to address HIV/AIDS in underserved communities. African Americans churches may be well-positioned to provide HIV education, screening, and support services, particularly if they are equipped with church-appropriate, easy-to-deliver HIV tools that can be implemented through the naturalistic church environment. To inform the development of a church-based HIV tool kit, we examined church capacity with African American church leaders (N = 124 participants; n = 58 churches represented by senior pastors). Nearly all participants (96%) wanted to learn more about HIV and how to discuss it with their parishioners. Regarding church capacity, most of their representative churches held three regular services each week, facilitated various inreach and community outreach ministries, and had paid staff and computers. Also, many of their churches facilitated HIV/AIDS education/prevention and adolescent sex education activities. Guided by church capacity findings, an ecological framework, and a CBPR approach, we describe the resulting church-based HIV Tool Kit that "fits" naturalistically within a multilevel church infrastructure, builds upon churches' HIV-related experience, and equips faith leaders to efficiently promote HIV services with the communities they serve.

  2. The Impact of Teacher Observations with Coordinated Professional Development on Student Performance: A 27-State Program Evaluation

    ERIC Educational Resources Information Center

    Shaha, Steven H.; Glassett, Kelly F.; Copas, Aimee

    2015-01-01

    The impact of teacher observations in alignment with professional development (PD) on teacher efficacy was quantified for 292 schools in 110 districts within 27 U.S. States. Teacher observations conducted by school leaders or designated internal coaches were coordinated with PD offerings aligned with intended teacher improvements. The PD involved…

  3. Students' Coordination of Geometric Reasoning and Measuring Strategies on a Fixed Perimeter Task: Developing Mathematical Understanding of Linear Measurement

    ERIC Educational Resources Information Center

    Barrett, Jeffrey E.; Clements, Douglas H.; Klanderman, David; Pennisi, Sarah-Jean; Polaki, Mokaeane V.

    2006-01-01

    This article examines students' development of levels of understanding for measurement by describing the coordination of geometric reasoning with measurement and numerical strategies. In analyzing the reasoning and argumentation of 38 Grade 2 through Grade 10 students on linear measure tasks, we found support for the application and elaboration of…

  4. Activity Participation Intensity Is Associated with Skeletal Development in Pre-Pubertal Children with Developmental Coordination Disorder

    ERIC Educational Resources Information Center

    Tsang, William W. N.; Guo, X.; Fong, Shirley S. M.; Mak, Kwok-Kei; Pang, Marco Y. C.

    2012-01-01

    Purpose: This study aimed (1) to compare the skeletal maturity and activity participation pattern between children with and without developmental coordination disorder (DCD); and (2) to determine whether activity participation pattern was associated with the skeletal development among children with DCD. Materials and methods: Thirty-three children…

  5. Developing a New System to Measure Outcomes in a Service Coordination Program for Youth with Severe Emotional Disturbance

    ERIC Educational Resources Information Center

    Shannon, Lisa M.; Walker, Robert; Blevins, Michele

    2009-01-01

    This paper presents information on re-developing an outcome evaluation for a state-funded program providing service coordination utilizing wraparound to youth with severe emotional disturbance (SED) and their families. Originally funded by the Robert Wood Johnson Foundation, the Kentucky IMPACT program has existed statewide since 1990. Changing…

  6. Coordinated Health and Human Resources Development: Report of a WHO Study Group. Technical Report Series No. 801.

    ERIC Educational Resources Information Center

    World Health Organization, Geneva (Switzerland).

    This report explores the theory and practice of coordinated health and human resources development as a concept that can help guard against the production of inappropriate categories or numbers of health personnel. The report concentrates of what can be done to make education and training programs more directly responsive to the priority needs in…

  7. Coordination and Integration of Military Education with National Career Education. Phase I: Career Development in Selected Occupations.

    ERIC Educational Resources Information Center

    Brown, Michael W.; And Others

    The report describes the initial phase of a study of coordination and integration of career education in the military with the national career education effort. The study was undertaken in recognition of the potential significance of the military as a career education resource in society, and in recognition of the need to develop a concept of…

  8. "The Spiral Model for the Development of Coordination": A Learning Model Based on Eshkol-Wachman Movement Notation (EWMN)

    ERIC Educational Resources Information Center

    Al-Dor, Nira

    2006-01-01

    The objective of this study is to present "The Spiral Model for the Development of Coordination" (SMDC), a learning model that reflects the complexity and possibilities embodied in the learning of movement notation Eshkol-Wachman (EWMN), an Israeli invention. This model constituted the infrastructure for a comprehensive study that examined the…

  9. Psychometric Properties of the Caregiver Assessment of Movement Participation Scale for Screening Children with Development Coordination Disorders

    ERIC Educational Resources Information Center

    Tsang, Kwan Lan; Bond, Trevor; Lo, Sing Kai

    2010-01-01

    Using Rasch analysis, the psychometric properties of a newly developed 35-item parent-proxy instrument, the Caregiver Assessment of Movement Participation (CAMP), designed to measure movement participation problems in children with Developmental Coordination Disorder, were examined. The CAMP was administered to 465 school children aged 5-10 years.…

  10. The importance of foetal movement for co-ordinated cartilage and bone development in utero

    PubMed Central

    Shea, C. A.; Rolfe, R. A.; Murphy, P.

    2015-01-01

    Construction of a functional skeleton is accomplished through co-ordination of the developmental processes of chondrogenesis, osteogenesis, and synovial joint formation. Infants whose movement in utero is reduced or restricted and who subsequently suffer from joint dysplasia (including joint contractures) and thin hypo-mineralised bones, demonstrate that embryonic movement is crucial for appropriate skeletogenesis. This has been confirmed in mouse, chick, and zebrafish animal models, where reduced or eliminated movement consistently yields similar malformations and which provide the possibility of experimentation to uncover the precise disturbances and the mechanisms by which movement impacts molecular regulation. Molecular genetic studies have shown the important roles played by cell communication signalling pathways, namely Wnt, Hedgehog, and transforming growth factor-beta/bone morphogenetic protein. These pathways regulate cell behaviours such as proliferation and differentiation to control maturation of the skeletal elements, and are affected when movement is altered. Cell contacts to the extra-cellular matrix as well as the cytoskeleton offer a means of mechanotransduction which could integrate mechanical cues with genetic regulation. Indeed, expression of cytoskeletal genes has been shown to be affected by immobilisation. In addition to furthering our understanding of a fundamental aspect of cell control and differentiation during development, research in this area is applicable to the engineering of stable skeletal tissues from stem cells, which relies on an understanding of developmental mechanisms including genetic and physical criteria. A deeper understanding of how movement affects skeletogenesis therefore has broader implications for regenerative therapeutics for injury or disease, as well as for optimisation of physical therapy regimes for individuals affected by skeletal abnormalities. Cite this article: Bone Joint Res 2015;4:105–116 PMID:26142413

  11. Development and testing of a 25-item patient satisfaction scale for black South African diabetic outpatients.

    PubMed

    Westaway, M S; Rheeder, P; van Zyl, D G; Seager, J R

    2002-08-01

    Although there is general agreement that patient satisfaction is an integral component of service quality, there is a paucity of South African research on reliable and valid satisfaction measures and the effects of health status on satisfaction. A 25-item patient satisfaction scale was developed and tested for evaluating the quality of health care for black diabetic outpatients. It was hypothesised that: (1) the underlying dimensions of patient satisfaction were interpersonal and organisational; and (2) patients in poor health would be less satisfied with the quality of their care than patients in good health. The questionnaire was administered to 263 black outpatients from Pretoria Academic Hospital and Kalafong Hospital. Factor analysis was conducted on the patient satisfaction scale and three factors, accounting for 71% of the variance, were extracted. The major items on Factor I were helpfulness, communication, support and consideration, representing the interpersonal dimension. Factors II and III were mainly concerned with service logistics and technical expertise, with the emphasis on waiting time, follow-up and thoroughness of examination. The three factors had excellent reliability coefficients, ranging between 0.82 (technical), 0.85 (logistics) and 0.98 (interpersonal). Multiple analyses of co-variance showed that patients in poor general health were significantly less satisfied with the logistical (p = 0.004) and technical (p = 0.007) quality of their care than patients in good health; patients in poor mental health were significantly less satisfied with the interpersonal quality of their care (p = 0.05) than patients in good mental health. These findings provided support for both hypotheses and suggested that patients in poor health attend to different aspects of their care than patients in good health. Of more importance to clinical practice, the results endorsed the need for a multidisciplinary health team comprising nurse/social worker (Factor I

  12. Collaborative development of clinical trials education programs for African-American community-based organizations.

    PubMed

    Blakeney, Natasha; Michaels, Margo; Green, Melissa; Richmond, Alan; Long, Debra; Robinson, William S; Spicer, Carmelita; Elliott-Bynum, Sharon; Corbie-Smith, Giselle

    2015-06-01

    This paper describes the use of a unique "Learning and Feedbackˮ approach to customize cancer clinical trials education programs for Community Bridges, a peer training intervention designed for African-American communities in North Carolina. Generic community education modules were demonstrated with key community leaders who were designated as trainers. Quantitative and qualitative assessments were provided on understanding of content, comfort with material, and cultural relevance. The generic materials were adapted into three revised modules, all featuring key messages about cancer clinical trials, discussion regarding distrust of medical research, common misconceptions about trials, patient protections, and a call to action to prompt increased inquiry about locally available trials. The revised modules were then used as part of a train-the-trainer program with 12 African-American community leaders. ENACCT's use of the Learning and Feedback process is an innovative method for culturally adapting clinical trials education.

  13. Collaborative development of clinical trials education programs for African-American community-based organizations.

    PubMed

    Blakeney, Natasha; Michaels, Margo; Green, Melissa; Richmond, Alan; Long, Debra; Robinson, William S; Spicer, Carmelita; Elliott-Bynum, Sharon; Corbie-Smith, Giselle

    2015-06-01

    This paper describes the use of a unique "Learning and Feedbackˮ approach to customize cancer clinical trials education programs for Community Bridges, a peer training intervention designed for African-American communities in North Carolina. Generic community education modules were demonstrated with key community leaders who were designated as trainers. Quantitative and qualitative assessments were provided on understanding of content, comfort with material, and cultural relevance. The generic materials were adapted into three revised modules, all featuring key messages about cancer clinical trials, discussion regarding distrust of medical research, common misconceptions about trials, patient protections, and a call to action to prompt increased inquiry about locally available trials. The revised modules were then used as part of a train-the-trainer program with 12 African-American community leaders. ENACCT's use of the Learning and Feedback process is an innovative method for culturally adapting clinical trials education. PMID:24906502

  14. Development of motor coordination and cerebellar structure in male and female rat neonates exposed to hypergravity

    NASA Astrophysics Data System (ADS)

    Nguon, K.; Ladd, B.; Baxter, M. G.; Sajdel-Sulkowska, E. M.

    2006-01-01

    We previously reported that the developing rat cerebellum is affected by exposure to hypergravity. In the present study, we explored the hypothesis that the changes in cerebellar structure in hypergravity-exposed rat neonates may affect their motor coordination. Furthermore, we hypothesized that the changes observed at 1.5G will be magnified at higher gravitational loading. To test this hypothesis, we compared motor behavior, cerebellar structure, and protein expression in rat neonates exposed to 1.5 1.75G on a 24-ft centrifuge daily for 22.5 h starting on gestational day (G) 10, through birth on G22/G23 and through postnatal day (P) 21. Exposure to hypergravity impacted the neurodevelopmental process as indicated by: (1) impaired righting response on P3, more than doubling the righting time at 1.75G, and (2) delayed onset of the startle response by one day, from P9 in controls to P10 in hypergravity-exposed pups. Hypergravity exposure resulted in impaired motor functions as evidenced by performance on a rotarod on P21; the duration of the stay on the rotarod recorded for 1.75G pups of both sexes was one tenth that of the stationary control (SC) pups. These changes in motor behavior were associated with cerebellar changes: (1) cerebellar mass on P6 was decreased by 7.5% in 1.5G-exposed male pups, 27.5% in 1.75G-exposed male pups, 17.5% in 1.5G-exposed female pups, and 22.5% in 1.75G female pups and (2) changes in the expression of glial and neuronal proteins. The results of this study suggest that perinatal exposure to hypergravity affects cerebellar development as evidenced by decreased cerebellar mass and altered cerebellar protein expression; cerebellar changes observed in hypergravity-exposed rat neonates are associated with impaired motor behavior. Furthermore, the response to hypergravity appears to be different in male and female neonates. If one accepts that the hypergravity paradigm is a useful animal model with which to predict those biological processes

  15. Timing Abilities among Children with Developmental Coordination Disorders (DCD) in Comparison to Children with Typical Development

    ERIC Educational Resources Information Center

    Rosenblum, Sara; Regev, Noga

    2013-01-01

    Timing ability is essential for common everyday performance. The aim of the study was to compare timing abilities and temporal aspects of handwriting performance and relationships between these two components among children with Developmental Coordination Disorders (DCD) and a control group. Forty two children, 21 diagnosed as DCD and 21 with…

  16. 76 FR 41987 - Interagency Working Group on Coordination of Domestic Energy Development and Permitting in Alaska

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-15

    ..., or agents, or any other person. (Presidential Sig.) THE WHITE HOUSE, July 12, 2011. [FR Doc. 2011... July 15, 2011 Part V The President Executive Order 13580--Interagency Working Group on Coordination of...-- #0;The President ] Executive Order 13580 of July 12, 2011 Interagency Working Group on...

  17. Coordinator's Training Guide. Research & Development Series No. 119-A. Career Planning Support System.

    ERIC Educational Resources Information Center

    Shaltry, Paul; Kester, Ralph J.

    One of a set of twelve documents describing the Career Planning Support System (CPSS) and its use, this guide is designed to help the CPSS coordinator become familiar with CPSS and his or her role. (The Career Planning Support System is a comprehensive guidance program management system which (1) provides techniques to improve a high school's…

  18. Specification of parameters for development of a spatial database for drought monitoring and famine early warning in the African Sahel

    NASA Technical Reports Server (NTRS)

    Rochon, Gilbert L.

    1989-01-01

    Parameters were described for spatial database to facilitate drought monitoring and famine early warning in the African Sahel. The proposed system, referred to as the African Drought and Famine Information System (ADFIS) is ultimately recommended for implementation with the NASA/FEMA Spatial Analysis and Modeling System (SAMS), a GIS/Dymanic Modeling software package, currently under development. SAMS is derived from FEMA'S Integration Emergency Management Information System (IEMIS) and the Pacific Northwest Laborotory's/Engineering Topographic Laboratory's Airland Battlefield Environment (ALBE) GIS. SAMS is primarily intended for disaster planning and resource management applications with the developing countries. Sources of data for the system would include the Developing Economics Branch of the U.S. Dept. of Agriculture, the World Bank, Tulane University School of Public Health and Tropical Medicine's Famine Early Warning Systems (FEWS) Project, the USAID's Foreign Disaster Assistance Section, the World Resources Institute, the World Meterological Institute, the USGS, the UNFAO, UNICEF, and the United Nations Disaster Relief Organization (UNDRO). Satellite imagery would include decadal AVHRR imagery and Normalized Difference Vegetation Index (NDVI) values from 1981 to the present for the African continent and selected Landsat scenes for the Sudan pilot study. The system is initially conceived for the MicroVAX 2/GPX, running VMS. To facilitate comparative analysis, a global time-series database (1950 to 1987) is included for a basic set of 125 socio-economic variables per country per year. A more detailed database for the Sahelian countries includes soil type, water resources, agricultural production, agricultural import and export, food aid, and consumption. A pilot dataset for the Sudan with over 2,500 variables from the World Bank's ANDREX system, also includes epidemiological data on incidence of kwashiorkor, marasmus, other nutritional deficiencies, and

  19. Development, implementation and evaluation of a unique African-American faith-based approach to increase automobile restraint use.

    PubMed Central

    Falcone, Richard A.; Brentley, Anita L.; Ricketts, Crystal D.; Allen, Sheryl E.; Garcia, Victor F.

    2006-01-01

    OBJECTIVE: Despite generalized intervention programs, restraint use among African Americans remains below national levels, especially among children. This study describes the development and implementation of a community participatory faith-based youth injury prevention program. METHODS: Through a partnership with the African-American faith-based community and our injury prevention group, a unique multigenerational intervention program was developed targeting motor vehicle restraint use. Once developed, the program was initially evaluated by comparing outcomes between control and intervention churches. The main objective was to observe adult and pediatric restraint use before and after program implementation. RESULTS: Overall, there was excellent recognition and participation in the program. Following program implementation, significant improvements were observed in restraint use compared to control churches. In particular, there was a 72% reduction in unrestrained children, a 25% increase in children being secured in the rear-seat position and a nearly 20% increase in driver restraint use. CONCLUSIONS: The development and implementation of a culturally sensitive intervention program can significantly improve restraint use in a minority population. Partnering with the community in all phases of the program is essential to its success. PMID:16916133

  20. Development of a Coordinated National Soil Moisture Network: A Pilot Study

    NASA Astrophysics Data System (ADS)

    Lucido, J. M.; Quiring, S. M.; Verdin, J. P.; Pulwarty, R. S.; Baker, B.; Cosgrove, B.; Escobar, V. M.; Strobel, M.

    2014-12-01

    Soil moisture data is critical for accurate drought prediction, flood forecasting, climate modeling, prediction of crop yields and water budgeting. However, soil moisture data are collected by many agencies and organizations in the United States using a variety of instruments and methods for varying applications. These data are often distributed and represented in disparate formats, posing significant challenges for use. In recognition of these challenges, the President's Climate Action Plan articulated the need for a coordinated national soil moisture network. In response to this action plan, a team led by the National Integrated Drought Information System has begun to develop a framework for this network and has instituted a proof-of-concept pilot study. This pilot is located in the south-central plains of the US, and will serve as a reference architecture for the requisite data systems and inform the design of the national network. The pilot comprises both in-situ and modeled soil moisture datasets (historical and real-time) and will serve the following use cases: operational drought monitoring, experimental land surface modeling, and operational hydrological modeling. The pilot will be implemented using a distributed network design in order to serve dispersed data in real-time directly from data providers. Standard service protocols will be used to enable future integration with external clients. The pilot network will additionally contain a catalog of data sets and web service endpoints, which will be used to broker web service calls. A mediation and aggregation service will then intelligently request, compile, and transform the distributed datasets from their native formats into a standardized output. This mediation framework allows data to be hosted and maintained locally by the data owners while simplifying access through a single service interface. These data services will then be used to create visualizations, for example, views of the current soil

  1. Development of a database for prompt gamma-ray neutron activation analysis: Summary report of the third research coordination meeting

    SciTech Connect

    Lindstrom, Richard M.; Firestone, Richard B.; Pavi, ???

    2003-04-01

    The main discussions and conclusions from the Third Co-ordination Meeting on the Development of a Database for Prompt Gamma-ray Neutron Activation Analysis are summarized in this report. All results were reviewed in detail, and the final version of the TECDOC and the corresponding software were agreed upon and approved for preparation. Actions were formulated with the aim of completing the final version of the TECDOC and associated software by May 2003.

  2. Skeletal development in the African elephant and ossification timing in placental mammals.

    PubMed

    Hautier, Lionel; Stansfield, Fiona J; Allen, W R Twink; Asher, Robert J

    2012-06-01

    We provide here unique data on elephant skeletal ontogeny. We focus on the sequence of cranial and post-cranial ossification events during growth in the African elephant (Loxodonta africana). Previous analyses on ossification sequences in mammals have focused on monotremes, marsupials, boreoeutherian and xenarthran placentals. Here, we add data on ossification sequences in an afrotherian. We use two different methods to quantify sequence heterochrony: the sequence method and event-paring/Parsimov. Compared with other placentals, elephants show late ossifications of the basicranium, manual and pedal phalanges, and early ossifications of the ischium and metacarpals. Moreover, ossification in elephants starts very early and progresses rapidly. Specifically, the elephant exhibits the same percentage of bones showing an ossification centre at the end of the first third of its gestation period as the mouse and hamster have close to birth. Elephants show a number of features of their ossification patterns that differ from those of other placental mammals. The pattern of the initiation of the ossification evident in the African elephant underscores a possible correlation between the timing of ossification onset and gestation time throughout mammals.

  3. The Role of Neighborhood in the Development of Aggression in Urban African American Youth: A Multilevel Analysis.

    PubMed

    Romero, Edna; Richards, Maryse H; Harrison, Patrick R; Garbarino, James; Mozley, Michaela

    2015-09-01

    The purpose of this study was to examine the role of neighborhood disadvantage and perceptions of neighborhood on the development of aggressive behavior among a sample of urban low-income African American middle school aged youth (mean age = 11.65 years). Results of hierarchical linear modeling indicated that youth experienced significant changes in rates of aggression across the three middle school years, and that on average, negative youth perceptions of neighborhood predicted increases in aggression. Both parent and youth perceptions of neighborhood disadvantage trended toward significance as a moderator between objective neighborhood characteristics and aggression. These results are in accordance with past research, which suggests that personal evaluations of the disadvantage of a neighborhood influence child development and behavior. Future studies should examine the role that perceptions play in youth development, as well as in interventions geared towards thwarting youth aggression.

  4. The UCAR Africa Initiative: Enabling African Solutions to African Needs

    NASA Astrophysics Data System (ADS)

    Pandya, R.; Bruintjes, R.; Foote, B.; Heck, S.; Hermann, S.; Hoswell, L.; Konate, M.; Kucera, P.; Laing, A.; Lamptey, B.; Moncrieff, M.; Ramamurthy, M.; Roberts, R.; Spangler, T.; Traoré, A.; Yoksas, T.; Warner, T.

    2007-12-01

    The University Corporation for Atmospheric Research (UCAR) Africa Initiative (AI) is a coordinated effort aimed at building sustainable partnerships between UCAR and African institutions in order to pursue research and applications for the benefit of the African people. The initiative is based on four fundamental operating principles, concisely summarized by the overall philosophy of enabling African solutions to African needs. The four principles are: • Collaborate with African institutions • Focus on institutional capacity building and research support • Explore science research themes critical to Africa and important for the world • Leverage the research infrastructure in UCAR to add value These principles are realized in a set of pilot activities, chosen for their high probability of short-term results and ability to set the stage for longer-term collaboration. The three pilot activities are listed below. 1. A modest radar network and data-distribution system in Mali and Burkina Faso, including a data-sharing MOU between the Mail and Burkina Faso Weather Services. 2. A partnership among UCAR, the Ghana Meteorological Agency, and the Ghana university community to develop an operational Weather Research and Forecasting (WRF) model for West Africa. The output is used by researchers and operational forecasters in Africa. Model output is also part of a demonstration project that aims to allow humanitarian agencies to share geo-referenced information in Africa via a web portal. 3. A workshop in Ouagadougou, Burkina Faso from April 2-6, 2007, with the theme Improving Lives by Understanding Weather. The workshop, co-organized with Programme SAAGA and the Commité Permanent Inter-Etats de Lutte Contre la Sécheresse dans le Sahel (CILSS), included over 80 participants from 18 countries, and produced a set of recommendations for continued collaboration. Our presentation will provide an update of these pilot activities and point to future directions. Recognizing

  5. Effects of Individual and School-Level Characteristics on a Child’s Gross Motor Coordination Development

    PubMed Central

    Chaves, Raquel; Baxter-Jones, Adam; Gomes, Thayse; Souza, Michele; Pereira, Sara; Maia, José

    2015-01-01

    The aim of this study was to identify child and school-level characteristics that explained inter-individual differences in gross motor coordination (GMC). Participants (n = 390), recruited from 18 Portuguese primary schools, were aged 6 to 10 years of age. Birth weight, body fat (BF), physical activity (PA), physical fitness (PF) and GMC were assessed. School size, setting, infrastructure and physical education classes were considered as school context markers. A multilevel modeling approach was used to identify hierarchical effects (child and school levels). It was found that children-level variables (sex, PF, and BF) significantly explained 63% of the 90% variance fraction at the individual level; boys outperformed girls (p < 0.05), individuals with higher BF were less coordinated (p < 0.05), and those with higher PF were more coordinated (p < 0.05). School-variables (e.g. school size and playing surface) explained 84% of the 10% variation fraction. These findings confirm the roles of sex, PFS and BF. Interestingly they also suggest that the school environment plays a minor but significant role in GMC development. However, it is important to stress that the school context and conditions can also play an important role in a child’s motor development, providing adequate and enriching motor opportunities. PMID:26264007

  6. The politics of African energy development: Ethiopia's hydro-agricultural state-building strategy and clashing paradigms of water security.

    PubMed

    Verhoeven, Harry

    2013-11-13

    As key economic, ecological and demographic trends converge to reshape Africa and its relationship with the outside world, a new politics is emerging in the twenty-first century around the water-food-energy nexus, which is central to the continent's relevance in the global economy. On the one hand, Malthusian anxieties are proliferating; pessimists link population growth and growing water scarcity to state failure and 'water wars'. On the other hand, entrepreneurs, sovereign wealth funds and speculators consider Africa's potential in water resources, energy production and food output as one of the last great untapped opportunities for the global economy: Africa is on the brink of an agro-industrial transformation. This article examines how African actors are not merely responding to economic and environmental changes but also thinking politically about water, food and energy security. Many of them are seizing the new opportunities to redefine their national politics, their relationship with local communities and their ties with external players, regionally and globally. Ethiopia's project of hydro-agricultural state-building helps to identify the most important fault lines of this new politics at the national, local and international level. The politics of water security and energy development simultaneously puts African states and their populations on the defensive, as they grapple with huge challenges, but also provides them with unique opportunities to take advantage of a more favourable global configuration of forces.

  7. The politics of African energy development: Ethiopia's hydro-agricultural state-building strategy and clashing paradigms of water security.

    PubMed

    Verhoeven, Harry

    2013-11-13

    As key economic, ecological and demographic trends converge to reshape Africa and its relationship with the outside world, a new politics is emerging in the twenty-first century around the water-food-energy nexus, which is central to the continent's relevance in the global economy. On the one hand, Malthusian anxieties are proliferating; pessimists link population growth and growing water scarcity to state failure and 'water wars'. On the other hand, entrepreneurs, sovereign wealth funds and speculators consider Africa's potential in water resources, energy production and food output as one of the last great untapped opportunities for the global economy: Africa is on the brink of an agro-industrial transformation. This article examines how African actors are not merely responding to economic and environmental changes but also thinking politically about water, food and energy security. Many of them are seizing the new opportunities to redefine their national politics, their relationship with local communities and their ties with external players, regionally and globally. Ethiopia's project of hydro-agricultural state-building helps to identify the most important fault lines of this new politics at the national, local and international level. The politics of water security and energy development simultaneously puts African states and their populations on the defensive, as they grapple with huge challenges, but also provides them with unique opportunities to take advantage of a more favourable global configuration of forces. PMID:24080620

  8. Successes and challenges of north–south partnerships – key lessons from the African/Asian Regional Capacity Development projects

    PubMed Central

    Färnman, Rosanna; Diwan, Vishal; Zwarenstein, Merrick; Atkins, Salla

    2016-01-01

    Introduction Increasing efforts are being made globally on capacity building. North–south research partnerships have contributed significantly to enhancing the research capacity in low- and middle-income countries (LMICs) over the past few decades; however, a lack of skilled researchers to inform health policy development persists, particularly in LMICs. The EU FP7 funded African/Asian Regional Capacity Development (ARCADE) projects were multi-partner consortia aimed to develop a new generation of highly trained researchers from universities across the globe, focusing on global health-related subjects: health systems and services research and research on social determinants of health. This article aims to outline the successes, challenges and lessons learned from the life course of the projects, focusing on the key outputs and experiences of developing and implementing these two projects together with sub-Saharan African, Asian and European institution partners. Design Sixteen participants from 12 partner institutions were interviewed. The data were analysed using thematic content analysis, which resulted in four themes and three sub-categories. These data were complemented by a review of project reports. Results The results indicated that the ARCADE projects have been successful in developing and delivering courses, and have reached over 920 postgraduate students. Some partners thought the north–south and south–south partnerships that evolved during the project were the main achievement. However, others found there to be a ‘north–south divide’ in certain aspects. Challenges included technical constraints and quality assurance. Additionally, adapting new teaching and learning methods into current university systems was challenging, combined with not being able to award students with credits for their degrees. Conclusion The ARCADE projects were introduced as an innovative and ambitious project idea, although not designed appropriately for all partner

  9. Addressing the Issue of Gender Equity in the Presidency of the University System in the Southern African Development Community (SADC) Region

    ERIC Educational Resources Information Center

    Guramatunhu-Mudiwa, Precious

    2010-01-01

    The Southern African Development Community (SADC) is a regional economic grouping of 15 countries whose common vision is to promote economic, social and political development and growth. Arguably, sustainable growth can be realized if there is equal access to all positions of power and influence in the area, but an investigation of 117…

  10. Human Capital Development (HCD) through Open, Distance and E-Learning: Evidence from Corporate Annual Reports (CARs) of Top South African Listed Companies

    ERIC Educational Resources Information Center

    Adelowotan, Mo

    2014-01-01

    This paper discusses the role of open, distance and e-learning in the development of human resources by examining human capital development related disclosures in the corporate annual reports (CARs) of top South African listed companies. The study employed content analysis method to analyse the CARs of these companies with the aid of qualitative…

  11. Inequities and Lack of Professionalisation of Early Childhood Development Practice Hinder Opportunities for Mathematics Stimulation and Realisation of South African Policy on Quality Education for All

    ERIC Educational Resources Information Center

    Feza, Nosisi

    2014-01-01

    White Paper 5's aim is to provide South Africa's children with a solid foundation for lifelong learning and development. Children need to be nurtured and developed holistically for them to participate efficiently in their democratic society. However, South African students continue to perform poorly in Trends in International Mathematics…

  12. An Exploratory Study of Fathers’ Parenting Stress and Toddlers’ Social Development in Low-Income African American Families

    PubMed Central

    Cabrera, Natasha; Mitchell, Stephanie

    2010-01-01

    The present study tested Abidin’s (1992) parenting stress model in a sample of low-income African American fathers and their toddlers, specifically examining the mediation effect of fathers’ engagement (self-report and observed) on the association between parenting stress and children’s social competence and problem behavior. We found that fathers reported moderate levels of parenting stress, but we found no evidence of a direct effect of stress on children’s social development. However, parenting stress predicted more engagement in management, which predicted children’s increased problem behaviour. These findings highlight the effect of fathering stress on specific forms of father engagement that affect toddlers’ social development. PMID:20190875

  13. Intervention Mapping as a Participatory Approach to Developing an HIV prevention Intervention in Rural African American Communities

    PubMed Central

    Corbie-Smith, Giselle; Akers, Aletha; Blumenthal, Connie; Council, Barbara; Wynn, Mysha; Muhammad, Melvin; Stith, Doris

    2011-01-01

    Southeastern states are among the hardest hit by the HIV epidemic in this country, and racial disparities in HIV rates are high in this region. This is particularly true in our communities of interest in rural eastern North Carolina. Although most recent efforts to prevent HIV attempt to address multiple contributing factors, we have found few multilevel HIV interventions that have been developed, tailored or tested in rural communities for African Americans. We describe how Project GRACE integrated Intervention Mapping (IM) methodology with community based participatory research (CBPR) principles to develop a multi-level, multi-generational HIV prevention intervention. IM was carried out in a series of steps from review of relevant data through producing program components. Through the IM process, all collaborators agreed that we needed a family-based intervention involving youth and their caregivers. We found that the structured approach of IM can be adapted to incorporate the principles of CBPR. PMID:20528128

  14. Patient-Centered mHealth Living Donor Transplant Education Program for African Americans: Development and Analysis

    PubMed Central

    Sieverdes, John Christopher; Nemeth, Lynne S; Magwood, Gayenell S; Baliga, Prabhakar K; Chavin, Kenneth D; Brunner-Jackson, Brenda; Patel, Sachin K; Ruggiero, Kenneth J

    2015-01-01

    Background There is a critical need to expand the pool of available kidneys for African Americans who are on the transplant wait-list due to the disproportionally lower availability of deceased donor kidneys compared with other races/ethnic groups. Encouraging living donation is one method to fill this need. Incorporating mHealth strategies may be a way to deliver educational and supportive services to African American transplant-eligible patients and improve reach to those living in remote areas or unable to attend traditional group-session-based programs. Before program development, it is essential to perform formative research with target populations to determine acceptability and cultivate a patient-centered and culturally relevant approach to be used for program development. Objective The objectives of this study were to investigate African American kidney transplant recipients’ and kidney donors’/potential donors’ attitudes and perceptions toward mobile technology and its viability in an mHealth program aimed at educating patients about the process of living kidney donation. Methods Using frameworks from the technology acceptance model and self-determination theory, 9 focus groups (n=57) were administered to African Americans at a southeastern medical center, which included deceased/living donor kidney recipients and living donors/potential donors. After a demonstration of a tablet-based video education session and explanation of a group-based videoconferencing session, focus groups examined members’ perceptions about how educational messages should be presented on topics pertaining to the process of living kidney donation and the transplantation. Questionnaires were administered on technology use and perceptions of the potential program communication platform. Transcripts were coded and themes were examined using NVivo 10 software. Results Qualitative findings found 5 major themes common among all participants. These included the following: (1

  15. Development of a 3D immersive videogame to improve arm-postural coordination in patients with TBI

    PubMed Central

    2011-01-01

    Background Traumatic brain injury (TBI) disrupts the central and executive mechanisms of arm(s) and postural (trunk and legs) coordination. To address these issues, we developed a 3D immersive videogame-- Octopus. The game was developed using the basic principles of videogame design and previous experience of using videogames for rehabilitation of patients with acquired brain injuries. Unlike many other custom-designed virtual environments, Octopus included an actual gaming component with a system of multiple rewards, making the game challenging, competitive, motivating and fun. Effect of a short-term practice with the Octopus game on arm-postural coordination in patients with TBI was tested. Methods The game was developed using WorldViz Vizard software, integrated with the Qualysis system for motion analysis. Avatars of the participant's hands precisely reproducing the real-time kinematic patterns were synchronized with the simulated environment, presented in the first person 3D view on an 82-inch DLP screen. 13 individuals with mild-to-moderate manifestations of TBI participated in the study. While standing in front of the screen, the participants interacted with a computer-generated environment by popping bubbles blown by the Octopus. The bubbles followed a specific trajectory. Interception of the bubbles with the left or right hand avatar allowed flexible use of the postural segments for balance maintenance and arm transport. All participants practiced ten 90-s gaming trials during a single session, followed by a retention test. Arm-postural coordination was analysed using principal component analysis. Results As a result of the short-term practice, the participants improved in game performance, arm movement time, and precision. Improvements were achieved mostly by adapting efficient arm-postural coordination strategies. Of the 13 participants, 10 showed an immediate increase in arm forward reach and single-leg stance time. Conclusion These results support the

  16. Development of a spiritually based educational intervention to increase informed decision making for prostate cancer screening among church-attending African American men.

    PubMed

    Holt, Cheryl L; Wynn, Theresa A; Southward, Penny; Litaker, Mark S; Jeames, Sanford; Schulz, Emily

    2009-09-01

    One way of developing culturally relevant health communication in the African American church setting is to develop spiritually based interventions, in which the health message is framed by relevant spiritual themes and scripture. In this article we describe the development of a community health advisor(CHA)-led intervention aimed at increasing informed decision making (IDM) for prostate cancer screening among church-attending African American men. Full-color print educational booklets were developed and pilot tested with extensive community participation of church-attending African American men age-eligible for screening. The intervention development phase consisted of ideas solicited from an advisory panel of African American men (N = 10), who identified core content and developed the spiritual themes. In the intervention pilot testing phase, prototypes of the intervention materials were pilot tested for graphic appeal in two focus groups (N = 16), and content was tested for acceptability and comprehension using individual cognitive response interviews (N = 10). Recommendations were made for project branding and logo and for use of graphics of real people in the educational materials. Significant feedback was obtained from the focus groups, on the graphics, colors, fonts, continuity, titles, and booklet size/shape. The importance of working closely with the community when developing interventions is discussed, as well as the importance of pilot testing of educational materials. PMID:19731129

  17. CRMP4 and CRMP2 Interact to Coordinate Cytoskeleton Dynamics, Regulating Growth Cone Development and Axon Elongation.

    PubMed

    Tan, Minghui; Cha, Caihui; Ye, Yongheng; Zhang, Jifeng; Li, Sumei; Wu, Fengming; Gong, Sitang; Guo, Guoqing

    2015-01-01

    Cytoskeleton dynamics are critical phenomena that underpin many fundamental cellular processes. Collapsin response mediator proteins (CRMPs) are highly expressed in the developing nervous system, mediating growth cone guidance, neuronal polarity, and axonal elongation. However, whether and how CRMPs associate with microtubules and actin coordinated cytoskeletal dynamics remain unknown. In this study, we demonstrated that CRMP2 and CRMP4 interacted with tubulin and actin in vitro and colocalized with the cytoskeleton in the transition-zone in developing growth cones. CRMP2 and CRMP4 also interacted with one another coordinately to promote growth cone development and axonal elongation. Genetic silencing of CRMP2 enhanced, whereas overexpression of CRMP2 suppressed, the inhibitory effects of CRMP4 knockdown on axonal development. In addition, knockdown of CRMP2 or overexpression of truncated CRMP2 reversed the promoting effect of CRMP4. With the overexpression of truncated CRMP2 or CRMP4 lacking the cytoskeleton interaction domain, the promoting effect of CRMP was suppressed. These data suggest a model in which CRMP2 and CRMP4 form complexes to bridge microtubules and actin and thus work cooperatively to regulate growth cone development and axonal elongation.

  18. Orthopedic coordination of dentofacial development in skeletal Class II malocclusion in conjunction with edgewise therapy. Part I.

    PubMed

    Bass, N M

    1983-11-01

    The skeletal Class II malocclusion may be considered to develop as a failure of the coordinating process to maintain harmonious relationships within the developing dentofacial apparatus. If the skeletal elements are too far apart for adaptation to occur and/or if there are functional abnormalities of the orofacial musculature which inhibit coordination from taking place, a malocclusion will result. An orthopedic technique and appliance system has been developed with the intention of improving those factors responsible for the development and perpetuation of the skeletal Class II malocclusion in a primary stage of treatment. This is accomplished by means of restraint and redirection of forward maxillary growth and an increase in the velocity of mandibular growth. Concurrently, adverse soft-tissue influences are eliminated or ameliorated. Edgewise appliance therapy is subsequently carried out for the final correction. The subject is considered in two articles. This first article describes the effects of the restraint of maxillary growth on craniofacial development and the dental changes produced by a maxillary removable splint with extraoral traction and shows how they can be used clinically for correction of the skeletal Class II malocclusion. The experimental and clinical evidence supporting this approach is considered, and case histories show the clinical use of the maxillary splint. This form of maxillary therapy for the skeletal Class II malocclusion has limitations, and it is desirable for it to be incorporated into a comprehensive orthopedic system.

  19. Coordinate systems and transformations for 3D modeling: the unifying concept in the RADIUS common development environment

    NASA Astrophysics Data System (ADS)

    Quam, Lynn H.; Heller, Aaron J.

    1996-02-01

    The RADIUS Common Development Environment pulls together many diverse functions into an integrated whole. The main goal of the environment is to provide a system to do interactive modeling of 3-dimensional scenes from multiple images, as well as, providing an infrastructure to support the research in and implementation of image understanding-based algorithms for this and other tasks. The RCDE contains facilities for: CAD-system-like 3D modeling; image processing; electronic-light-table image viewing and exploitation; frame and non-frame camera photogrammetry; and photo realistic rendering. The major achievement of the system is the high level of integration and interoperability between and among these facilities. The key realization that enables this is that every entity represented in the RCDE has an associated local coordinate system. This includes cartographic and cultural features, images and sub-images, text annotations, graphical user interface elements, photogrammetric conjugate points and even the earth itself. These entities are tied together through a flexible and efficient network of coordinate transformations. This allows each type of data to be represented, manipulated, and displayed in the most convenient and precise form, without sacrificing functionality or generality, in addition to enabling the fusion of different types of geometric data. In this paper, we explain the coordinate system representations and transformation facilities in the RCDE and outline some of the rationale and strategies behind the current design and implementation. Also included are examples drawn from its use in the government sponsored RADIUS program.

  20. Reducing childhood obesity through coordinated care: Development of a park prescription program.

    PubMed

    Messiah, Sarah E; Jiang, Sandy; Kardys, Jack; Hansen, Eric; Nardi, Maria; Forster, Lourdes

    2016-08-01

    Major hindrances to controlling the current childhood obesity epidemic include access to prevention and/or treatment programs that are affordable, provide minimal barriers for participation, and are available to the general public. Moreover, successful childhood obesity prevention efforts will require coordinated partnerships in multiple sectors such as government, health care, school/afterschool, and the community but very few documented sustainable programs currently exist. Effective, community-based health and wellness programs with a focus on maintaining healthy weight via physical activity and healthy eating have the potential to be a powerful referral resource for pediatricians and other healthcare professionals who have young patients who are overweight/obese. The Miami Dade County Department of Parks, Recreation and Open Spaces in partnership with the University of Miami UHealth Systems have created a "Park Prescription Program (Parks Rx 4Health(TM))" that formally coordinates pediatricians, families, parents, caregivers, and child/adolescents to provide daily obesity-prevention activities. This Parks Rx 4Health(TM) program that we describe here allows UHealth pediatricians to seamlessly refer their overweight and obese patients to Fit2Play(TM), an evidence-based, park-based afterschool health and wellness program. Measurable outcomes that include body mass index, blood pressure, fitness, and nutrition knowledge are being collected at baseline and at 3-and 6-mo after referral to document patient progress. Results are then shared with the referring physician so they can follow up with the patient if necessary. Identifying successful models that integrate primary care, public health, and community-based efforts is important to accelerating progress in preventing childhood obesity. Effective, community-based health and wellness programs with a focus on physical activity and nutrition education could be a powerful referral resource for pediatricians who have

  1. Reducing childhood obesity through coordinated care: Development of a park prescription program

    PubMed Central

    Messiah, Sarah E; Jiang, Sandy; Kardys, Jack; Hansen, Eric; Nardi, Maria; Forster, Lourdes

    2016-01-01

    Major hindrances to controlling the current childhood obesity epidemic include access to prevention and/or treatment programs that are affordable, provide minimal barriers for participation, and are available to the general public. Moreover, successful childhood obesity prevention efforts will require coordinated partnerships in multiple sectors such as government, health care, school/afterschool, and the community but very few documented sustainable programs currently exist. Effective, community-based health and wellness programs with a focus on maintaining healthy weight via physical activity and healthy eating have the potential to be a powerful referral resource for pediatricians and other healthcare professionals who have young patients who are overweight/obese. The Miami Dade County Department of Parks, Recreation and Open Spaces in partnership with the University of Miami UHealth Systems have created a “Park Prescription Program (Parks Rx 4HealthTM)” that formally coordinates pediatricians, families, parents, caregivers, and child/adolescents to provide daily obesity-prevention activities. This Parks Rx 4HealthTM program that we describe here allows UHealth pediatricians to seamlessly refer their overweight and obese patients to Fit2PlayTM, an evidence-based, park-based afterschool health and wellness program. Measurable outcomes that include body mass index, blood pressure, fitness, and nutrition knowledge are being collected at baseline and at 3-and 6-mo after referral to document patient progress. Results are then shared with the referring physician so they can follow up with the patient if necessary. Identifying successful models that integrate primary care, public health, and community-based efforts is important to accelerating progress in preventing childhood obesity. Effective, community-based health and wellness programs with a focus on physical activity and nutrition education could be a powerful referral resource for pediatricians who have

  2. Reducing childhood obesity through coordinated care: Development of a park prescription program

    PubMed Central

    Messiah, Sarah E; Jiang, Sandy; Kardys, Jack; Hansen, Eric; Nardi, Maria; Forster, Lourdes

    2016-01-01

    Major hindrances to controlling the current childhood obesity epidemic include access to prevention and/or treatment programs that are affordable, provide minimal barriers for participation, and are available to the general public. Moreover, successful childhood obesity prevention efforts will require coordinated partnerships in multiple sectors such as government, health care, school/afterschool, and the community but very few documented sustainable programs currently exist. Effective, community-based health and wellness programs with a focus on maintaining healthy weight via physical activity and healthy eating have the potential to be a powerful referral resource for pediatricians and other healthcare professionals who have young patients who are overweight/obese. The Miami Dade County Department of Parks, Recreation and Open Spaces in partnership with the University of Miami UHealth Systems have created a “Park Prescription Program (Parks Rx 4HealthTM)” that formally coordinates pediatricians, families, parents, caregivers, and child/adolescents to provide daily obesity-prevention activities. This Parks Rx 4HealthTM program that we describe here allows UHealth pediatricians to seamlessly refer their overweight and obese patients to Fit2PlayTM, an evidence-based, park-based afterschool health and wellness program. Measurable outcomes that include body mass index, blood pressure, fitness, and nutrition knowledge are being collected at baseline and at 3-and 6-mo after referral to document patient progress. Results are then shared with the referring physician so they can follow up with the patient if necessary. Identifying successful models that integrate primary care, public health, and community-based efforts is important to accelerating progress in preventing childhood obesity. Effective, community-based health and wellness programs with a focus on physical activity and nutrition education could be a powerful referral resource for pediatricians who have

  3. Developing a Patient Care Co-ordination Centre in Trafford, England: lessons from the International Foundation for Integrated Care (IFIC)/Advancing Quality Alliance integrated care fellowship experience.

    PubMed

    Gregory, Michael

    2015-01-01

    The NHS and Social Care in England are facing one of the biggest financial challenges for a generation. Commissioners and providers need to work on collaborative schemes to manage the increasing demand on health and social care within a period of financial constraint. Different forms of care co-ordination have been developed at different levels across the world. In the north-west of England, the Trafford health and social care economy have been working through a competitive dialogue process with industry to develop an innovative and dynamic solution to deliver seamless co-ordination for all patients and service users. The strategy is to develop a new Patient Care Co-ordination Centre, which will be responsible for the delivery of co-ordinated, quality care. The Patient Care Co-ordination Centre will work at clinical, service, functional and community levels across multiple providers covering risk stratification, preventative, elective and unscheduled care. I am the clinical lead for the Patient Care Co-ordination Centre and during my year as an Advancing Quality Alliance Integrated Care Fellow, I have had the opportunity to study examples of care coordination from UK and international sites. The learning from these visits has been assimilated into the design process of the Patient Care Co-ordination Centre.

  4. Development of ten microsatellite loci in the invasive giant African land snail, Achatina (=Lissachatina) fulica Bowdich, 1822

    USGS Publications Warehouse

    Morrison, Cheryl L.; Springmann, Marcus J.; Iwanowicz, Deborah D.; Wade, Christopher M.

    2015-01-01

    A suite of tetra-nucleotide microsatellite loci were developed for the invasive giant African land snail, Achatina (=Lissachatina) fulica Bowdich, 1822, from Ion Torrent next-generation sequencing data. Ten of the 96 primer sets tested amplified consistently in 30 snails from Miami, Florida, plus 12 individuals representative of their native East Africa, Indian and Pacific Ocean regions. The loci displayed moderate levels of allelic diversity (average 5.6 alleles/locus) and heterozygosity (average 42 %). Levels of genetic diversity were sufficient to produce unique multi-locus genotypes and detect phylogeographic structuring among regional samples. The invasive A. fulica can cause extensive damage to important food crops and natural resources, including native flora and fauna. The loci characterized here will be useful for determining the origins and tracking the spread of invasions, detecting fine-scale spatial structuring and estimating demographic parameters.

  5. Fertilization and development of eggs of the South African clawed toad, Xenopus laevis, on sounding rockets in space

    NASA Astrophysics Data System (ADS)

    Ubbels, Geertje A.; Berendsen, Willem; Kerkvliet, Sonja; Narraway, Jenny

    Egg rotation and centrifugation experiments strongly suggest a role for gravity in the determination of the spatial structure of amphibian embryos. Decisive experiments can only be made in Space. Eggs of Xenopus laevis, the South African clawed toad, were the first vertebrate eggs which were successfully fertilized on Sounding Rockets in Space. Unfixed, newly fertilized eggs survived reentry, and a reasonable number showed a seemingly normal gastrulation but died between gastrulation and neurulation. Only a few reached the larval stage, but these developed abnormally. In the future, we inted to test whether this abnormal morphogenesis is due to reentry perturbations, or due to a real microgravity effect, through perturbation of the reinitiation of meiosis and other processes, or started by later sperm penetration.

  6. Development and Evaluation of a Complementary and Alternative Medicine Use Survey in African-Americans with Acquired Immune Deficiency Syndrome

    PubMed Central

    Sterk, Claire; McCarty, Frances; Hankerson-Dyson, Dana; DiClemente, Ralph

    2010-01-01

    Abstract Objectives The purpose of the current study was to develop and evaluate the psychometric properties of a culturally- and stage-of-disease-appropriate measure of complementary and alternative medicine (CAM) use among a population of African-American individuals with acquired immune deficiency syndrome (AIDS) using a mixed-method design. Design Data were collected in two phases. In phase 1, qualitative data were used to refine an existing CAM measure for the specific study population in the present study. In phase 2, this refined instrument was implemented in a larger sample. The resulting numeric data were analyzed to evaluate the psychometric properties of the revised CAM instrument. Setting Data were collected from patients who were receiving care from the infectious disease clinic of a large, public, urban hospital in the Southeastern United States. Subjects Patients were eligible to participate if they (1) were receiving their care from the clinic, (2) had an AIDS diagnosis, (3) were identified as African-American, (4) were ≥21 years of age, (5) spoke English, and (6) were not cognitively impaired. Measures Focus groups in phase 1 were conducted with a semistructured focus group guide. Participants also completed a basic sociodemographic survey. Phase 2 participants used programmed laptops to answer questions about their CAM use and several sociodemographic questions. Results Information from the focus groups prompted some substantive revisions in the already-existing CAM survey. The revised instrument had satisfactory face validity and adequate test–retest reliability (r = 0.79). Furthermore, the instrument factored in a manner that was interpretable and consistent with prior findings. Conclusions In order for human immunodeficiency virus health care providers to provide the best care to their patients, they need to be informed about the types and frequency of CAM use among their patients. This can be accomplished by methodologically developing

  7. African Regional Symposium on Telematics for Development. Report and Recommendations = Colloque regional africain la telematique au service du developpement. Rapport et recommandations (Addis Ababa, Ethiopia, April 3-7, 1995).

    ERIC Educational Resources Information Center

    International Telecommunication Union, Geneva (Switzerland).

    The African Regional Symposium on Telematics for Development was organized in view of the special educational and communication needs of Africa in a time of accelerating change and development of information technologies. The symposium brought together more than 150 African specialists, and over 40 participants from other regions and development…

  8. The miR156-SPL9-DFR pathway coordinates the relationship between development and abiotic stress tolerance in plants.

    PubMed

    Cui, Long-Gang; Shan, Jun-Xiang; Shi, Min; Gao, Ji-Ping; Lin, Hong-Xuan

    2014-12-01

    Young organisms have relatively strong resistance to diseases and adverse conditions. When confronted with adversity, the process of development is delayed in plants. This phenomenon is thought to result from the rebalancing of energy, which helps plants to coordinate the relationship between development and stress tolerance; however, the molecular mechanism underlying this phenomenon remains mysterious. In this study, we found that miR156 integrates environmental signals to ensure timely flowering, thus enabling the completion of breeding. Under stress conditions, miR156 is induced to maintain the plant in the juvenile state for a relatively long period of time, whereas under favorable conditions, miR156 is suppressed to accelerate the developmental transition. Blocking the miR156 signaling pathway in Arabidopsis thaliana with 35S::MIM156 (via target mimicry) increased the sensitivity of the plant to stress treatment, whereas overexpression of miR156 increased stress tolerance. In fact, this mechanism is also conserved in Oryza sativa (rice). We also identified downstream genes of miR156, i.e. SQUAMOSA PROMOTER BINDING PROTEIN-LIKE 9 (SPL9) and DIHYDROFLAVONOL-4-REDUCTASE (DFR), which take part in this process by influencing the metabolism of anthocyanin. Our results uncover a molecular mechanism for plant adaptation to the environment through the miR156-SPLs-DFR pathway, which coordinates development and abiotic stress tolerance. PMID:25345491

  9. The miR156-SPL9-DFR pathway coordinates the relationship between development and abiotic stress tolerance in plants.

    PubMed

    Cui, Long-Gang; Shan, Jun-Xiang; Shi, Min; Gao, Ji-Ping; Lin, Hong-Xuan

    2014-12-01

    Young organisms have relatively strong resistance to diseases and adverse conditions. When confronted with adversity, the process of development is delayed in plants. This phenomenon is thought to result from the rebalancing of energy, which helps plants to coordinate the relationship between development and stress tolerance; however, the molecular mechanism underlying this phenomenon remains mysterious. In this study, we found that miR156 integrates environmental signals to ensure timely flowering, thus enabling the completion of breeding. Under stress conditions, miR156 is induced to maintain the plant in the juvenile state for a relatively long period of time, whereas under favorable conditions, miR156 is suppressed to accelerate the developmental transition. Blocking the miR156 signaling pathway in Arabidopsis thaliana with 35S::MIM156 (via target mimicry) increased the sensitivity of the plant to stress treatment, whereas overexpression of miR156 increased stress tolerance. In fact, this mechanism is also conserved in Oryza sativa (rice). We also identified downstream genes of miR156, i.e. SQUAMOSA PROMOTER BINDING PROTEIN-LIKE 9 (SPL9) and DIHYDROFLAVONOL-4-REDUCTASE (DFR), which take part in this process by influencing the metabolism of anthocyanin. Our results uncover a molecular mechanism for plant adaptation to the environment through the miR156-SPLs-DFR pathway, which coordinates development and abiotic stress tolerance.

  10. Developing and testing lay literature about breast cancer screening for African American women.

    PubMed

    Coleman, Elizabeth Ann; Coon, Sharon; Mohrmann, Carolyn; Hardin, Susan; Stewart, Beth; Gibson, Regina Shoate; Cantrell, Mary; Lord, Janet; Heard, Jeanne

    2003-01-01

    Written materials about breast cancer screening for African American women with low literacy skills are needed. Available materials were not at or below third-grade reading levels, were not culturally sensitive, and were not accurate in illustrating correct breast self-examination (BSE) techniques. Focus groups representing the target population helped the authors design a pamphlet describing how to perform BSE and a motivational picture book to help women overcome barriers to screening. The authors chose a food theme for the cover of the pamphlet written at a third-grade level and suggested a photographic version. In the motivational book, two women address barriers to screening and replace myths and fears with facts and actions. Data from 162 women showed that they learned from both the photographic and illustrated versions. Women in the photographic group found significantly more lumps in the silicone models, so the authors chose that version to use in final testing. Finally, nurses pretested a group of patients before they reviewed the materials and post-tested another group after they reviewed them. The group who had reviewed the materials had greater knowledge of and intent to follow the guidelines and received higher scores on BSE techniques.

  11. APC/C-Cdh1 coordinates neurogenesis and cortical size during development

    NASA Astrophysics Data System (ADS)

    Delgado-Esteban, Maria; García-Higuera, Irene; Maestre, Carolina; Moreno, Sergio; Almeida, Angeles

    2013-12-01

    The morphology of the adult brain is the result of a delicate balance between neural progenitor proliferation and the initiation of neurogenesis in the embryonic period. Here we assessed whether the anaphase-promoting complex/cyclosome (APC/C) cofactor, Cdh1—which regulates mitosis exit and G1-phase length in dividing cells—regulates neurogenesis in vivo. We use an embryo-restricted Cdh1 knockout mouse model and show that functional APC/C-Cdh1 ubiquitin ligase activity is required for both terminal differentiation of cortical neurons in vitro and neurogenesis in vivo. Further, genetic ablation of Cdh1 impairs the ability of APC/C to promote neurogenesis by delaying the exit of the progenitor cells from the cell cycle. This causes replicative stress and p53-mediated apoptotic death resulting in decreased number of cortical neurons and cortex size. These results demonstrate that APC/C-Cdh1 coordinates cortical neurogenesis and size, thus posing Cdh1 in the molecular pathogenesis of congenital neurodevelopmental disorders, such as microcephaly.

  12. Development of a Coordinated National Soil Moisture Network: A Pilot Study

    NASA Astrophysics Data System (ADS)

    Quiring, S. M.; Lucido, J. M.; Winslow, L.; Ford, T.; Bijoy Baruah, P.; Verdin, J. P.; Pulwarty, R. S.; Strobel, M.

    2015-12-01

    Soil moisture is critical for accurate drought assessment and forecasting, identifying flood potential, climate modeling, estimation of crop yields and water budgeting. However, soil moisture data are collected by many agencies and organizations in the United States using a variety of instruments and methods for varying applications. These data are often distributed and represented in disparate formats, posing significant challenges for reuse. Recognizing this need, the President's Climate Action Plan called for the creation of a coordinated national soil moisture network. In response, a team led by the National Integrated Drought Information System has completed a proof-of-concept pilot project. The pilot comprises both in-situ and assimilated soil moisture datasets. It focuses on providing real-time soil moisture data via standard web services to feed map-based visualization tools in order to meet the following use cases: operational drought monitoring, experimental land surface modeling, and operational hydrological modeling. The result of this pilot is a reference architecture that will inform the implementation of the national network.

  13. Using Rolling to Develop Neuromuscular Control and Coordination of the Core and Extremities of Athletes

    PubMed Central

    Voight, Michael L.; Cook, Gray; Gill, Lance

    2009-01-01

    Rolling is a movement pattern seldom used by physical therapists for assessment and intervention with adult clientele with normal neurologic function. Rolling, as an adult motor skill, combines the use of the upper extremities, core, and lower extremities in a coordinated manner to move from one posture to another. Rolling is accomplished from prone to supine and supine to prone, although the method by which it is performed varies among adults. Assessment of rolling for both the ability to complete the task and bilateral symmetry may be beneficial for use with athletes who perform rotationally-biased sports such as golf, throwing, tennis, and twisting sports such as dance, gymnastics, and figure skating. Additionally, when used as intervention techniques, the rolling patterns have the ability to affect dysfunction of the upper quarter, core, and lower quarter. By applying proprioceptive neuromuscular facilitation (PNF) principles, the therapist may assist patients and clients who are unable to complete a rolling pattern. Examples given in the article include distraction/elongation, compression, and manual contacts to facilitate proper rolling. The combined experience of the four authors is used to describe techniques for testing, assessment, and treatment of dysfunction, using case examples that incorporate rolling. The authors assert that therapeutic use of the developmental pattern of rolling with techniques derived from PNF is a hallmark in rehabilitation of patients with neurologic dysfunction, but can be creatively and effectively utilized in musculoskeletal rehabilitation. PMID:21509112

  14. [Coupling coordination evaluation method between eco-environment quality and economic development level in contiguous special poverty-stricken areas of China].

    PubMed

    Wang, Yan-hui; Li, Jing-yi

    2015-05-01

    It is one of the important strategies in the new period of national poverty alleviation and development to maintain the basic balance between the ecological environment and economic development, and to promote the coordinated sustainable development of economy and ecological environment. Taking six contiguous special poverty-stricken areas as the study areas, a coupling coordination evaluation method between eco-environment quality and economic development level in contiguous special poverty-stricken areas was explored in this paper. The region' s ecological poverty index system was proposed based on the natural attribute of ecological environment, and the ecological environment quality evaluation method was built up by using AHP weighting method, followed by the design of the coupling coordination evaluation method between the ecological environment indices and the county economic poverty comprehensive indices. The coupling coordination degrees were calculated and their spatial representation differentiations were analyzed respectively at district, province, city, and county scales. Results showed that approximately half of the counties in the study areas achieved the harmoniously coordinated development. However, the ecological environmental quality and the economic development in most counties could not be synchronized, where mountains, rivers and other geographic features existed roughly as a dividing line of the coordinated development types. The phenomena of dislocation between the ecological environment and economic development in state-level poor counties were more serious than those of local poor counties. PMID:26571673

  15. [Coupling coordination evaluation method between eco-environment quality and economic development level in contiguous special poverty-stricken areas of China].

    PubMed

    Wang, Yan-hui; Li, Jing-yi

    2015-05-01

    It is one of the important strategies in the new period of national poverty alleviation and development to maintain the basic balance between the ecological environment and economic development, and to promote the coordinated sustainable development of economy and ecological environment. Taking six contiguous special poverty-stricken areas as the study areas, a coupling coordination evaluation method between eco-environment quality and economic development level in contiguous special poverty-stricken areas was explored in this paper. The region' s ecological poverty index system was proposed based on the natural attribute of ecological environment, and the ecological environment quality evaluation method was built up by using AHP weighting method, followed by the design of the coupling coordination evaluation method between the ecological environment indices and the county economic poverty comprehensive indices. The coupling coordination degrees were calculated and their spatial representation differentiations were analyzed respectively at district, province, city, and county scales. Results showed that approximately half of the counties in the study areas achieved the harmoniously coordinated development. However, the ecological environmental quality and the economic development in most counties could not be synchronized, where mountains, rivers and other geographic features existed roughly as a dividing line of the coordinated development types. The phenomena of dislocation between the ecological environment and economic development in state-level poor counties were more serious than those of local poor counties.

  16. Incorporating the Notion of Recontextualisation in Academic Literacies Research: The Case of a South African Vocational Web Design and Development Course

    ERIC Educational Resources Information Center

    Coleman, Lynn

    2012-01-01

    This article describes a small scale ethnographically oriented research study seeking to contribute to understanding student academic literacy practices in a South African vocational, web design and development course. In this course digital multimodal assessments are the main means whereby students demonstrate their learning. The findings of the…

  17. Technical Education and Vocational Training in Central Africa. Feasibility Survey of the Regional Development of Rapid Vocational Training: Cameroon, Central African Republic, Chad, and Gabon.

    ERIC Educational Resources Information Center

    Organization for Rehabilitation through Training, Geneva (Switzerland).

    This final report is the result of a survey requested by the United States Agency for International Development (USAID) and undertaken by the Organization for Rehabilitation through Training (ORT) of four countries (Cameroon, Chad, Central African Republic, and Gabon) and a conference on vocational training sponsored by the Economic and Customs…

  18. The Audio-Visual Services in Fifteen African Countries. Comparative Study on the Administration of Audio-Visual Services in Advanced and Developing Countries. Part Four. First Edition.

    ERIC Educational Resources Information Center

    Jongbloed, Harry J. L.

    As the fourth part of a comparative study on the administration of audiovisual services in advanced and developing countries, this UNESCO-funded study reports on the African countries of Cameroun, Republic of Central Africa, Dahomey, Gabon, Ghana, Kenya, Libya, Mali, Nigeria, Rwanda, Senegal, Swaziland, Tunisia, Upper Volta and Zambia. Information…

  19. Women Reading for Education, Affinity & Development (WREAD): An Evaluation of a Semistructured Reading Discussion Group for African American Female Adult-Literacy Students with Histories of Trauma

    ERIC Educational Resources Information Center

    Jones, Jayatta D.

    2012-01-01

    Women Reading for Education, Affinity & Development (WREAD), a reading discussion group geared toward African American female adult-literacy students with self-defined histories of trauma, was an outgrowth of research identifying links between trauma, women's struggles with literacy, and the need to be conscious of emotional health…

  20. Effects of a Preschool Intervention on Cognitive Development among East-African Preschool Children: A Flexibly Time-Coded Growth Model

    ERIC Educational Resources Information Center

    Malmberg, Lars-Erik; Mwaura, Peter; Sylva, Kathy

    2011-01-01

    The aim of the study is to investigate the effects of the Madrasa Resource Center (MRC), a child-centered intervention program, on East-African (Kenya, Zanzibar, and Uganda) preschool children's cognitive development. Altogether 321 children (153 non-intervention and 168 intervention) participated in a cross-sequential study over three time-points…

  1. Cumulative Psychosocial and Medical Risk as Predictors of Early Infant Development and Parenting Stress in an African-American Preterm Sample

    ERIC Educational Resources Information Center

    Candelaria, Margo A.; O'Connell, Melissa A.; Teti, Douglas M.

    2006-01-01

    The present study examined predictive linkages between cumulative psychosocial and medical risk, assessed neonatally, and infant development and parenting stress at 4 months of infant corrected age. Predominantly low-income, African-American mothers and their preterm infants served as participants. Cumulative psychosocial risk predicted early…

  2. From Boys to KINGS: Examining the Perceptions and Perspectives of African American Male Participants of the 100 KINGS Youth Development Program

    ERIC Educational Resources Information Center

    Smith, Rodney D.

    2011-01-01

    This study explored the perceptions and perspectives of African American male students with regard to their experiences in a youth development initiative sponsored by a community-based organization. This examination aimed to ascertain the aspects of the program that, first, prompted the students to be a part of the initiative, but also those…

  3. Development and Implementation of an AIDS Prevention Program for African-American Women at a Child Care Center.

    ERIC Educational Resources Information Center

    Moten-Tolson, Paula

    This program was designed to provide Acquired Immune Deficiency Syndrome (AIDS) prevention education for African-American women of child bearing age at a child care center which serves low income high risk families. The primary goal was to reduce the risk of African-American women at the child care center for contracting the Human Immunodeficiency…

  4. Report on BAAL "Language in Africa" SIG Meetings Reading in African Languages: Developing Literacies and Reading Methodologies

    ERIC Educational Resources Information Center

    Wildsmith-Cromarty, Rosemary

    2015-01-01

    This report describes ongoing research on reading in African languages. It draws mainly on contributions from two British Association for Applied Linguistics (BAAL) "Language in Africa" (LiA) Special Interest Group (SIG) meetings: the LiA SIG strand at BAAL 2013 and the seminar on "Reading Methodologies in African Languages"…

  5. Fear of Neighborhood Violence During Adolescence Predicts Development of Obesity a Decade Later: Gender Differences Among African Americans

    PubMed Central

    Assari, Shervin; Moghani Lankarani, Maryam; Caldwell, Cleopatra Howard; Zimmerman, Marc A

    2016-01-01

    Background African American youth are more likely than other racial and ethnic groups to be obese. African American youth are also more likely to live in disadvantaged neighborhoods which increase their victimization, observation, and fear of violence. Objectives This study tested if victimization, observation, and fear of violence in the neighborhood during adolescence predict trajectory of body mass index (BMI) in the 3rd decade of life in African Americans. Patients and Methods Data came from an 18-year community-based cohort. We used multi-group latent growth curve modeling for data analysis, considering neighborhood violence at age 15 (i.e. victimization, observation, and fear) as predictors, and the linear slope for the average change in BMI from age 21 to 32 as the outcome, with age and socioeconomic status (i.e. intact family and parental employment) as covariates. Results Fear of neighborhood violence at age 15 was predictive of an increase in BMI from age 21 to 32 among female but not male African Americans. Victimization and observation of violence at age 15 did not predict BMI change from age 21 to 32 among female or male African Americans. Conclusions Fear of neighborhood violence is a contributing factor to increased risk of obesity for female African American youth who live in disadvantaged areas. This finding has implications for prevention of obesity among African American women who are at highest risk for obesity in the United States. Initiatives that enhance neighborhood safety are critical strategies for obesity prevention among African American women.

  6. The Impact of Oakland Freedom School's Summer Youth Program on the Psychosocial Development of African American Youth

    ERIC Educational Resources Information Center

    Bethea, Sharon L.

    2012-01-01

    The present investigation considers the program outcomes of one community youth project, Leadership Excellence Inc., Oakland Freedom Schools. Oakland Freedom Schools are culturally relevant 6-week summer Language Arts enrichment programs for primarily inner-city African American youth aged 5 to 14 years. In this study, 79 African American youth…

  7. The Relationship between Media Influence and Ethnic Identity Development among Low-Income African American and White Adolescent Girls

    ERIC Educational Resources Information Center

    Byrd, Kenycia

    2013-01-01

    The purpose of this study was to examine the relationship between media influence and ethnic identity among low-income African American and White adolescent girls. According to the U.S. Census (2008), 98% of Americans have a television in their home. Prior research suggests that low-income African American adolescents are exposed to more media…

  8. Perceptions of family history and genetic testing and feasibility of pedigree development among African Americans with hypertension

    PubMed Central

    Pettey, Christina M; McSweeney, Jean C; Stewart, Katharine E; Price, Elvin T; Cleves, Mario A; Heo, Seongkum; Souder, Elaine

    2016-01-01

    Background Pedigree development, family history, and genetic testing are thought to be useful in improving outcomes of chronic illnesses such as hypertension (HTN). However, the clinical utility of pedigree development is still unknown. Further, little is known about African Americans’ (AAs’) perceptions of family history and genetic testing. Aims This study examined the feasibility of developing pedigrees for AAs with HTN and explored perceptions of family history and genetic research among AAs with HTN. Methods The US Surgeon General’s My Family Health Portrait was administered, and 30–60 minute in-person individual interviews were conducted. Descriptive statistics were used to analyze pedigree data. Interview transcripts were analyzed with content analysis and constant comparison. Results Twenty-nine AAs with HTN were recruited from one free clinic (15 women, 14 men; mean age 49 years, SD 9.6). Twenty-six (90%) reported their family history in sufficient detail to develop a pedigree. Perceptions of family history included knowledge of HTN in the family, culturally influenced family teaching about HTN, and response to family history of HTN. Most participants agreed to future genetic testing and DNA collection because they wanted to help others; some said they needed more information and others expressed a concern for privacy. Conclusion The majority of AAs in this sample possessed extensive knowledge of HTN within their family and were able to develop a three generation pedigree with assistance. The majority were willing to participate in future genetic research. PMID:25322748

  9. The African yam bean seed lectin affects the development of the cowpea weevil but does not affect the development of larvae of the legume pod borer.

    PubMed

    Machuka, J S; Okeola, O G; Chrispeels, M J; Jackai, L E

    2000-03-01

    Artificial feeding assays were used to study the effect of purified galactose-specific lectins from African yam beans (Sphenostylis stenocarpa) on development of larvae of the cowpea weevil, Callosobruchus maculatus (Coleoptera : Bruchidae) and the legume pod-borer, Maruca vitrata (Lepidoptera : Pyrialidae). Inhibition of development of C. maculatus was observed when larvae were fed on artificial cowpea seeds containing 0.2%, 2.0% and 5.0% (wt/wt) of dietary lectin. Larval mortality was between 30% and 88%, while delays in total developmental time ranged between 7 and 13 days. The lectin had no effect on development of larvae of M. vitrala, when tested through topical artificial diet incorporation assays, except at the extremely high dose of 35% dietary level.

  10. Development of pendulum mechanism and kinematic coordination from the first unsupported steps in toddlers.

    PubMed

    Ivanenko, Yuri P; Dominici, Nadia; Cappellini, Germana; Dan, Bernard; Cheron, Guy; Lacquaniti, Francesco

    2004-10-01

    The inverted pendulum model in which the centre of mass of the body vaults over the stance leg in an arc represents a basic mechanism of bipedal walking. Is the pendulum mechanism innate, or is it learnt through walking experience? We studied eight toddlers (about 1 year old) at their first unsupported steps, 18 older children (1.3-13 years old), and ten adults. Two infants were also tested repeatedly over a period of 4 months before the onset of independent walking. Pendulum mechanism was quantified from the kinematics of the greater trochanter, correlation between kinetic and gravitational potential energy of the centre of body mass obtained from the force plate recordings, and percentage of recovery of mechanical energy. In toddlers, these parameters deviated significantly (P<10(-5)) from those of older children and adults, indicating that the pendulum mechanism is not implemented at the onset of unsupported locomotion. Normalising the speed with the Froude number showed that the percentage of recovery of mechanical energy in children older than 2 years was roughly similar to that of the adults (less than 5% difference), in agreement with previous results. By contrast, the percentage of recovery in toddlers was much lower (by about 50%). Pendulum-like behaviour and fixed coupling of the angular motion of the lower limb segments rapidly co-evolved toward mature values within a few months of independent walking experience. Independent walking experience acts as a functional trigger of the developmental changes, as shown by the observation that gait parameters remained unchanged until the age of the first unsupported steps, and then rapidly matured after that age. The findings suggest that the pendulum mechanism is not an inevitable mechanical consequence of a system of linked segments, but requires active neural control and an appropriate pattern of inter-segmental coordination.

  11. Astrocyte morphology, heterogeneity, and density in the developing African giant rat (Cricetomys gambianus).

    PubMed

    Olude, Matthew A; Mustapha, Oluwaseun A; Aderounmu, Oluwatunde A; Olopade, James O; Ihunwo, Amadi O

    2015-01-01

    Astrocyte morphologies and heterogeneity were described in male African giant rats (AGR; Cricetomys gambianus, Waterhouse) across three age groups (five neonates, five juveniles, and five adults) using Silver impregnation method and immunohistochemistry against glial fibrillary acidic protein. Immunopositive cell signaling, cell size and population were least in neonates, followed by adults and juveniles, respectively. In neonates, astrocyte processes were mostly detected within the glia limitans of the mid and hind brain; their cell bodies measuring 32 ± 4.8 μm in diameter against 91 ± 5.4 μm and 75 ± 1.9 μm in juveniles and adults, respectively. Astrocyte heterogeneity in juvenile and adult groups revealed eight subtypes to include fibrous astrocytes chiefly in the corpus callosum and brain stem, protoplasmic astrocytes in the cortex and dentate gyrus (DG); radial glia were found along the olfactory bulb (OB) and subventricular zone (SVZ); velate astrocytes were mainly found in the cerebellum and hippocampus; marginal astrocytes close to the pia mater; Bergmann glia in the molecular layer of the cerebellum; perivascular and periventricular astrocytes in the cortex and third ventricle, respectively. Cell counts from twelve anatomical regions of the brain were significantly higher in juveniles than in adults (p ≤ 0.01) using unpaired student t-test in the cerebral cortex, pia, corpus callosum, rostral migratory stream, DG, and cerebellum. Highest astrocyte count was found in the DG, while the least count was in the brain stem and sub cortex. Astrocytes along the periventricular layer of the OB are believed to be part of the radial glia system that transport newly formed cells towards the hippocampus and play roles in neurogenesis migration and homeostasis in the AGR. Therefore, astrocyte heterogeneity was examined across age groups in the AGR to determine whether age influences astrocytes population in different regions of the AGR brain and discuss possible

  12. Shared Platform for South African Earth and Environmental Observation Systems: Recent Developments and Improvements

    NASA Astrophysics Data System (ADS)

    Hugo, Wim

    2013-04-01

    Over the past 3 years, SAEON has worked with a number of stakeholders and funders to establish a shared platform for the management of dissemination of E&EO research outputs, data sets, and services. This platform is strongly aligned with GEO principles and architecture, allowing direct integration with the GEOSS Broker. The platform has two important characteristics: 1. It reduces the cost and lead time of provision of similar infrastructure for future initiatives. 2. The platform is domain-agnostic to some degree, and can be used for non E&EO applications. Projects to achive this is under way at present. The paper describes the application of the platform for a variety of user communities and initiatives (SAEON Data Portal, South African Earth Observation System, Risk and Vulnerability Atlas, BioEnergy Atlas, National Spatial Information Framework, ICSU World Data System Components, and many more), and demonstrates use cases utilising a distributed, service oriented architecture. Significant improvements have been made to the interoperability functions available to end users and content providers, and these are demonstrated and discussed in detail. Functions include • Creation and persistence of composite maps, as well as time series or scatter charts, supporting a variety of standardized data sources. • Search facilities have been extended to allow analysis and filtering of primary search results, and to deal with large meta-data collections. • In addition, data sources, data listings, news items, images, search results, and other platform content can, with increasing flexibility, be accessed as standardized services that are processed in standardized clients, allowing creation of a rich user interface, and permitting the inclusion of platform functionality into external websites and resources. This shift to explicit service-oriented, peer-to-peer architecture is a preparation for increased distributed processing and content composition, and will support

  13. Development and Implementation of Mass Media Campaigns to Delay Sexual Initiation Among African American and White Youth

    PubMed Central

    NOAR, SETH M.; ZIMMERMAN, RICK S.; PALMGREEN, PHILIP; CUPP, PAMELA K.; FLOYD, BRENIKKI R.; MEHROTRA, PURNIMA

    2015-01-01

    Reducing new HIV/STD infections among at-risk adolescents requires developing and evaluating evidence-based health communication approaches. Research over-whelmingly supports the conclusion that early sexual initiation is associated with STDs and other negative outcomes in later years (e.g., unintended pregnancy). The authors’ research group secured funding from the National Institute of Mental Health to develop, implement, and rigorously evaluate televised mass media campaigns to delay initiation of sexual intercourse among African American and White adolescents in two cities in the Southeastern United States. The focus of the present study is on the development and implementation of the campaigns, including (a) rationale and theoretical underpinnings; (b) collection, screening, and assessment of existing public service announcements; (c) development of new public service announcements; (d) study design and campaign airing plan; and (e) message exposure achieved in the campaigns. Health communication campaigns hold much promise in reaching at-risk adolescent populations with targeted, timely, and relevant risk-reduction messages. PMID:24093220

  14. Timing and tempo: Exploring the complex association between pubertal development and depression in African American and European American girls

    PubMed Central

    Keenan, Kate; Culbert, Kristen; Grimm, Kevin J.; Hipwell, Alison; Stepp, Stephanie

    2014-01-01

    The relative contribution of pubertal timing and tempo to the development of depression has not been tested in a large, representative sample, nor has the interface among pubertal maturation, depression, and race. Participants were a community-based sample of 2,450 girls from the Pittsburgh Girls Study (PGS) who were interviewed annually from ages 9 to 17 years. Pubertal timing and tempo were characterized as a unitary construct and also separately for pubic hair and breast development using child and maternal report. Depression symptoms were assessed annually. African-American females had higher depression symptoms and progressed through puberty earlier, but at a slower tempo than European American girls. Girls with earlier timing had higher levels of depression symptoms at age 10 years. Slower tempo was associated with higher depression symptoms at age 10, and faster tempo was associated with increases in depression from ages 10 to 13. As well, race moderated the associations among timing, tempo, and depression symptoms, and the association between race and depression was partially mediated by pubertal timing and tempo. Pubertal timing and tempo and race contribute to the developmental course of depression from early to late adolescence. The pattern of association varies as a function of the developmental window within which depression is assessed. Thus, repeated measures of depression symptoms and puberty across the span of pubertal development are necessary for exploring the relative importance of dimensions of pubertal development to depression etiology. PMID:25314262

  15. Timing and tempo: Exploring the complex association between pubertal development and depression in African American and European American girls.

    PubMed

    Keenan, Kate; Culbert, Kristen M; Grimm, Kevin J; Hipwell, Alison E; Stepp, Stephanie D

    2014-11-01

    The relative contribution of pubertal timing and tempo to the development of depression has not been tested in a large, representative sample, nor has the interface among pubertal maturation, depression, and race been tested. Participants were a community-based sample of 2,450 girls from the Pittsburgh Girls Study who were interviewed annually from ages 9 to 17 years. Pubertal timing and tempo were characterized as a unitary construct and also separately for pubic hair and breast development using child and maternal report. Depression symptoms were assessed annually. African American girls had higher depression symptoms and progressed through puberty earlier, but at a slower tempo than European American girls. Girls with earlier timing had higher levels of depression symptoms at age 10 years. Slower tempo was associated with higher depression symptoms at age 10, and faster tempo was associated with increases in depression from ages 10 to 13. As well, race moderated the associations among timing, tempo, and depression symptoms, and the association between race and depression was partially mediated by pubertal timing and tempo. Pubertal timing and tempo and race contribute to the developmental course of depression from early to late adolescence. The pattern of association varies as a function of the developmental window within which depression is assessed. Thus, repeated measures of depression symptoms and puberty across the span of pubertal development are necessary for exploring the relative importance of dimensions of pubertal development to depression etiology.

  16. Uncovering Black/African American and Latina/o students' motivation to learn science: Affordances to science identity development

    NASA Astrophysics Data System (ADS)

    Mahfood, Denise Marcia

    The following dissertation reports on a qualitative exploration that serves two main goals: (1) to qualitatively define and highlight science motivation development of Black/African American and Latina/o students as they learn science in middle school, high school, and in college and (2) to reveal through personal narratives how successful entry and persistence in science by this particular group is linked to the development of their science identities. The targeted population for this study is undergraduate students of color in science fields at a college or university. The theoretical frameworks for this study are constructivist theory, motivation theory, critical theory, and identity theories. The methodological approach is narrative which includes students' science learning experiences throughout the course of their academic lives. I use The Science Motivation Questionnaire II to obtain baseline data to quantitatively assess for motivation to learn science. Data from semi-structured interviews from selected participants were collected, coded, and configured into a story, and emergent themes reveal the important role of science learning in both informal and formal settings, but especially in informal settings that contribute to better understandings of science and the development of science identities for these undergraduate students of color. The findings have implications for science teaching in schools and teacher professional development in science learning.

  17. Estrogen promotes the development of mouse cumulus cells in coordination with oocyte-derived GDF9 and BMP15.

    PubMed

    Sugiura, Koji; Su, You-Qiang; Li, Qinglei; Wigglesworth, Karen; Matzuk, Martin M; Eppig, John J

    2010-12-01

    The differentiation and function of cumulus cells depend upon oocyte-derived paracrine factors, but studies on the estrogen receptor knockout mice suggested that estrogen also participates in these processes. This study investigates the possible coordination of estrogen and oocytes in the development and function of cumulus cells using cumulus expansion and the expression of transcripts required for expansion as functional endpoints. Preantral granulosa cell-oocyte complexes developed in vitro with 17β-estradiol (E2) exhibited increased levels of cumulus expansion and Has2 transcripts, encoding hyaluronan synthase 2, compared with those developed without E2. Moreover, cumulus cell-oocyte complexes (COCs) isolated from antral follicles and maintained in culture without E2 exhibited reduced cumulus expansion and Has2 mRNA levels compared with freshly isolated COCs. Exogenous E2, provided during the maintenance culture, alleviated these deficiencies. However, when oocytes were removed from COCs, E2 supplementation did not maintain competence to undergo expansion; the presence in culture of either fully grown oocytes or recombinant growth differentiation factor 9 (GDF9) was required. Recombinant bone morphogenetic protein 15, but not fibroblast growth factor 8, augmented the GDF9 effect. Oocytes or GDF9 suppressed cumulus cell levels of Nrip1 transcripts encoding nuclear receptor-interacting protein 1, a potential inhibitor of estrogen receptor signals. Therefore, E2 and oocyte-derived paracrine factors GDF9 and bone morphogenetic protein 15 coordinate to promote the development of cumulus cells and maintain their competence to undergo expansion. Furthermore, suppression of Nrip1 expression in cumulus cells by oocyte may be one mechanism mediating cross talk between oocyte and E2 signals that promotes follicular development.

  18. Research on the Coordinative Development of Regional Higher Education and Economy

    ERIC Educational Resources Information Center

    Hong, Yingjun

    2012-01-01

    In the current society, economic development in any region has to rely on higher education. Conversely, higher education cannot do without regional economic development in order to achieve greater progress in scale and level. Starting with the function of higher education in Wenzhou, this paper analyzes the reality and problems in Wenzhou's higher…

  19. Attributing the Success to the Coordinated Development of Education and the Economy.

    ERIC Educational Resources Information Center

    Zheng, Hongjie; and Han, Qinglin

    1990-01-01

    Describes the role of education in the development of the economy of a village in Sichuan province. Uses the planning employed by this village as a model and furnishes examples of specific steps taken to confront multiple problems in providing education for growth and economic development. (NL)

  20. Assessment of the National Wind Coordinating Collaborative: Addressing Environmental and Siting Issues Associated with Wind Energy Development

    SciTech Connect

    Van Cleve, Frances B.; States, Jennifer C.

    2010-11-09

    The National Wind Coordinating Collaborative (NWCC) is a consensus-based stakeholder group comprised of representatives from the utility, wind industry, environmental, consumer, regulatory, power marketer, agricultural, tribal, economic development, and state and federal government sectors. The purpose of the NWCC is to support the development of an environmentally, economically, and politically sustainable commercial market for wind power (NWCC 2010). The NWCC has been funded by the U.S. Department of Energy (DOE) since its inception in 1994. In order to evaluate the impact of the work of the NWCC and how this work aligns with DOE’s strategic priorities, DOE tasked Pacific Northwest National Laboratory (PNNL) to conduct a series of informal interviews with a small sample of those involved with NWCC.

  1. Development of a model of machine hand eye coordination and program specifications for a topological machine vision system

    NASA Technical Reports Server (NTRS)

    1972-01-01

    A unified approach to computer vision and manipulation is developed which is called choreographic vision. In the model, objects to be viewed by a projected robot in the Viking missions to Mars are seen as objects to be manipulated within choreographic contexts controlled by a multimoded remote, supervisory control system on Earth. A new theory of context relations is introduced as a basis for choreographic programming languages. A topological vision model is developed for recognizing objects by shape and contour. This model is integrated with a projected vision system consisting of a multiaperture image dissector TV camera and a ranging laser system. System program specifications integrate eye-hand coordination and topological vision functions and an aerospace multiprocessor implementation is described.

  2. Lessons Learned from the Development and Implementation of Two Internet-enhanced Culturally Relevant Physical Activity Interventions for Young Overweight African-American Women

    PubMed Central

    Joseph, Rodney P.; Pekmezi, Dori W.; Allison, Jeroan J.; Durant, Nefertiti H.

    2014-01-01

    This research team has designed and implemented 2 culturally relevant, Internet-enhanced physical activity (PA) interventions for overweight/obese African-American female college students. Presumably, these are the only prospectively designed, culturally relevant interventions using the Internet to promote PA among African-American women. Due to the limited research on this topic, the experiences associated the design and implementation of these studies were syntesized and 5 key lessons learned from this research were formulated. Findings provide insight for researchers to consider when developing Internet-based PA promotion interventions for African-American women. Lessons learned included: 1) Elicit and incorporate feedback from the target population throughout development of an Internet-based PA promotion tool; 2) Incorporate new and emerging technologies into Internet-enhanced PA programs; 3) Maintain frequent participant contact and provide frequent incentives to promote participant engagement; 4) Supplement Internet-based efforts with face-to-face interactions; 5) Include diverse images of African-American women and culturally relevant PA-related information in Internet-based PA promotion materials. PMID:25653465

  3. MicroRNA-8 promotes robust motor axon targeting by coordinate regulation of cell adhesion molecules during synapse development

    PubMed Central

    Lu, Cecilia S.; Zhai, Bo; Mauss, Alex; Landgraf, Matthias; Gygi, Stephen; Van Vactor, David

    2014-01-01

    Neuronal connectivity and specificity rely upon precise coordinated deployment of multiple cell-surface and secreted molecules. MicroRNAs have tremendous potential for shaping neural circuitry by fine-tuning the spatio-temporal expression of key synaptic effector molecules. The highly conserved microRNA miR-8 is required during late stages of neuromuscular synapse development in Drosophila. However, its role in initial synapse formation was previously unknown. Detailed analysis of synaptogenesis in this system now reveals that miR-8 is required at the earliest stages of muscle target contact by RP3 motor axons. We find that the localization of multiple synaptic cell adhesion molecules (CAMs) is dependent on the expression of miR-8, suggesting that miR-8 regulates the initial assembly of synaptic sites. Using stable isotope labelling in vivo and comparative mass spectrometry, we find that miR-8 is required for normal expression of multiple proteins, including the CAMs Fasciclin III (FasIII) and Neuroglian (Nrg). Genetic analysis suggests that Nrg and FasIII collaborate downstream of miR-8 to promote accurate target recognition. Unlike the function of miR-8 at mature larval neuromuscular junctions, at the embryonic stage we find that miR-8 controls key effectors on both sides of the synapse. MiR-8 controls multiple stages of synapse formation through the coordinate regulation of both pre- and postsynaptic cell adhesion proteins. PMID:25135978

  4. MicroRNA-8 promotes robust motor axon targeting by coordinate regulation of cell adhesion molecules during synapse development.

    PubMed

    Lu, Cecilia S; Zhai, Bo; Mauss, Alex; Landgraf, Matthias; Gygi, Stephen; Van Vactor, David

    2014-09-26

    Neuronal connectivity and specificity rely upon precise coordinated deployment of multiple cell-surface and secreted molecules. MicroRNAs have tremendous potential for shaping neural circuitry by fine-tuning the spatio-temporal expression of key synaptic effector molecules. The highly conserved microRNA miR-8 is required during late stages of neuromuscular synapse development in Drosophila. However, its role in initial synapse formation was previously unknown. Detailed analysis of synaptogenesis in this system now reveals that miR-8 is required at the earliest stages of muscle target contact by RP3 motor axons. We find that the localization of multiple synaptic cell adhesion molecules (CAMs) is dependent on the expression of miR-8, suggesting that miR-8 regulates the initial assembly of synaptic sites. Using stable isotope labelling in vivo and comparative mass spectrometry, we find that miR-8 is required for normal expression of multiple proteins, including the CAMs Fasciclin III (FasIII) and Neuroglian (Nrg). Genetic analysis suggests that Nrg and FasIII collaborate downstream of miR-8 to promote accurate target recognition. Unlike the function of miR-8 at mature larval neuromuscular junctions, at the embryonic stage we find that miR-8 controls key effectors on both sides of the synapse. MiR-8 controls multiple stages of synapse formation through the coordinate regulation of both pre- and postsynaptic cell adhesion proteins.

  5. Gesture production in school vs. clinical samples of children with Developmental Coordination Disorder (DCD) and typically developing children.

    PubMed

    Sinani, Charikleia; Sugden, David A; Hill, Elisabeth L

    2011-01-01

    Dyspraxia, a difficulty in executing an operationalised act, has been associated with Developmental Coordination Disorder (DCD). However, issues relating to the area such as comparisons across modalities, comparisons of school vs. clinical populations, and developmental delay vs. pathology have not been addressed in the same, comprehensive study. In the current study, therefore, familiar gesture production in DCD was addressed in a comprehensive manner to follow-up outstanding issues from previous studies: The production of familiar gestures and praxis imagery in a school (n=26) vs. clinic sample (n=19) of children with DCD was examined in relation to typically developing age matched (n=24) all aged from 9 to 11 years, and two groups of younger children within the age ranges of 5-6 (n=23) and 4-5 (n=26) years. Overall, children with Developmental Coordination Disorder showed an impaired ability to produce familiar gestures compared to their typical peers, and this was dependant on the type of gesture and presentation modality. Differences were found between school and clinic samples of children with DCD, suggestive of the recruitment of different underlying mechanisms in the two samples. The results have a bearing on our understanding of the relationship of developmental dyspraxia to DCD, as well as of the issue of developmental delay vs. pathology. PMID:21353461

  6. "The problem with running"--comparing the propulsion strategy of children with developmental coordination disorder and typically developing children.

    PubMed

    Diamond, Nicola; Downs, Jenny; Morris, Susan

    2014-01-01

    Children with Developmental Coordination Disorder (DCD) often have difficulties running. This study compared strategies of propulsion and power generation at the ankle during late stance/early swing in both walking and running in children with and without DCD. Eleven children (six male) aged nine to 12 years with DCD were matched by sex and age with 11 typically developing (TD) children. Gait kinematics and kinetics were measured during 4 gait types; normal walking, fast walking, jogging and sprinting using three-dimensional motion analysis. Propulsion strategy during gait was calculated as ankle power divided by the sum of ankle and hip power (A2/A2+H3). The children with DCD ran slower than the TD children (mean difference [MD] when jogging 0.3m/s and sprinting 0.8m/s). Adjusting for speed, those with DCD had smaller propulsion strategy values during jogging (p=0.001) and sprinting (p=0.012), explained by reduced ankle power generation at push off (A2) (jogging, MD 2.5 W/kg, p<0.001) and greater hip flexor power generation at pull off (H3) (jogging, MD 0.75 W/kg, p=0.013). Similar findings were observed during sprinting. Children with DCD ran with a slow and less efficient running style compared with TD children. Physiotherapy targeting running-specific needs in relation to ankle muscle strength and coordination could enable more participation in running activities.

  7. Combining detrital geochronology and sedimentology to assess basin development in the Rukwa Rift of the East African Rift System

    NASA Astrophysics Data System (ADS)

    Hilbert-Wolf, Hannah; Roberts, Eric; Mtelela, Cassy; Downie, Bob

    2015-04-01

    We have employed a multifaceted approach to sedimentary provenance analysis in order to assess the timing and magnitude of tectonic events, sedimentation, and landscape development in the Western Branch of the East African Rift System. Our approach, termed 'Sedimentary Triple Dating', integrates: (1) U-Pb dating via LA-ICPMS; (2) fission track; and (3) (U-Th)/He thermochronology of detrital zircon and apatite. We integrate geochronology, thermochronology, and provenance analysis to relate the initiation of rifting events to regional dynamic uplift, sedimentation patterns, and interpret the far-reaching climatic and evolutionary effects of fluctuating rift flank topography in the Rukwa Rift, a segment of the Western Branch. This work provides additional data to support the recent concept of synchronous development of the Western and Eastern branches of the East African Rift System ~25 Ma, and better constrains the age, location and provenance of subsequent rifting and sedimentation events in the Rukwa Rift Basin. Investigation of well cuttings and outcrop samples from the Neogene-Recent Lake Beds Succession in the Rukwa Rift Basin revealed a suite of previously unrecognized tuffaceous deposits at the base of the succession. A population of euhedral, magmatic zircons from a basal Lake Beds tuff and Miocene-Pliocene detrital zircons from well cuttings suggest that Neogene rift reactivation and volcanism began ~9-10 Ma. This timing is consistent with demonstrated rifting in Uganda and Malawi, as well as with the initiation of volcanism in the Rungwe Volcanic Province at the southern end of the Rukwa Rift, and the estimated development of Lake Tanganyika to the north. Moreover, there appear to be a suite of unconformity bounded stratigraphic units that make up the Lower Lake Beds succession, and detrital zircon maximum depositional ages from these units suggests episodic sedimentation in the rift, punctuated by long hiatuses or uplift, rather than steady subsidence and

  8. Voices of Identity and Responsibility: A Description of the Development of Identity, Using Cross' Theory of Nigrescence, and the Manifestation of Responsibility among African-American Urban School Principals

    ERIC Educational Resources Information Center

    Byrd, Clavon, Sr.

    2009-01-01

    This research described the retrospective formation of identity and manifestation of responsibility of four African-American female leaders who served as urban school principals. Cross (1971, 1991) determined that African-Americans undergo a four step process of identity development that he coined Nigrescence. Within these four stages of identity…

  9. Oligodendrocyte ablation affects the coordinated interaction between granule and Purkinje neurons during cerebellum development

    SciTech Connect

    Collin, Ludovic; Doretto, Sandrine; Malerba, Monica; Ruat, Martial; Borrelli, Emiliana . E-mail: borrelli@uci.edu

    2007-08-01

    Oligodendrocytes (OLs) are the glial cells of the central nervous system (CNS) classically known to be devoted to the formation of myelin sheaths around most axons of the vertebrate brain. We have addressed the role of these cells during cerebellar development, by ablating OLs in vivo. Previous analyses had indicated that OL ablation during the first six postnatal days results into a striking cerebellar phenotype, whose major features are a strong reduction of granule neurons and aberrant Purkinje cells development. These two cell types are highly interconnected during cerebellar development through the production of molecules that help their proliferation, differentiation and maintenance. In this article, we present data showing that OL ablation has major effects on the physiology of Purkinje (PC) and granule cells (GC). In particular, OL ablation results into a reduction of sonic hedgehog (Shh), Brain Derived Neurotrophic Factor (BDNF), and Reelin (Rln) expression. These results indicate that absence of OLs profoundly alters the normal cerebellar developmental program.

  10. Coordination of Organic Curriculum Development in the Public Schools of Mineola, New York. Final Report.

    ERIC Educational Resources Information Center

    Spack, Eliot G.

    This report describes organic curriculum development, the redefinition of goals, and the overhaul of the educational process in the public schools of Mineola, New York. In May 1967, superintendents met in Florida to establish the initial network for the program entitled the Educational System for the Seventies (ES '70). This report reflects the…

  11. Developing Coordinated, Multimodal, School Based Treatment for Young Adolescents with ADHD

    ERIC Educational Resources Information Center

    Evans, Steven W.; Timmins, Bebhinn; Sibley, Maggie; White, L. Casey; Serpell, Zewelanji N.; Schultz, Brandon

    2006-01-01

    Adolescents with ADHD experience serious impairment that taxes our education, mental health, and healthcare systems as well as the children and families. The development and evaluation of effective treatments for these youth have lagged far behind that of many other disorders and age groups. This manuscript describes the treatment development…

  12. Direct Radiative Effect of Mineral Dust on the Development of African Easterly Waves in Late Summer, 2003-07

    SciTech Connect

    Ma, Po-Lun; Zhang, Kai; Shi, Jainn Jong; Matsui, Toshihisa; Arking, Albert

    2012-12-19

    Episodic events of both Saharan dust outbreaks and African easterly waves (AEWs) are observed to move westward over the eastern tropical Atlantic Ocean. The relationship between the warm, dry, and dusty Saharan air layer on the nearby storms has been the subject of considerable debate. In this study, the Weather Research and Forecasting model is used to investigate the radiative effect of dust on the development of AEWs during August and September, the months of maximumtropical cyclone activity, in years 2003–07. The simulations show that dust radiative forcing enhances the convective instability of the environment. As a result, mostAEWsintensify in the presence of a dust layer. The Lorenz energy cycle analysis reveals that the dust radiative forcing enhances the condensational heating, which elevates the zonal and eddy available potential energy. In turn, available potential energy is effectively converted to eddy kinetic energy, in which local convective overturning plays the primary role. The magnitude of the intensification effect depends on the initial environmental conditions, including moisture, baroclinity, and the depth of the boundary layer. The authors conclude that dust radiative forcing, albeit small, serves as a catalyst to promote local convection that facilitates AEW development.

  13. Direct Radiative Effect of Mineral Dust on the Development of African Easterly Wave in Late Summer, 2003-2007

    NASA Technical Reports Server (NTRS)

    Ma, Po-Lun; Zhang, Kai; Shi, Jainn Jong; Matsui, Toshihisa; Arking, Albert

    2012-01-01

    Episodic events of both Saharan dust outbreaks and African Easterly Waves (AEWs) are observed to move westward over the eastern tropical Atlantic Ocean. The relationship between the warm, dry, and dusty Saharan Air Layer (SAL) on the nearby storms has been the subject of considerable debate. In this study, the Weather Research and Forecasting (WRF) model is used to investigate the radiative effect of dust on the development of AEWs during August and September, the months of maximum tropical cyclone activity, in years 2003-2007. The simulations show that dust radiative forcing enhances the convective instability of the environment. As a result, most AEWs intensify in the presence of a dust layer. The Lorenz energy cycle analysis reveals that the dust radiative forcing enhances the condensational heating, which elevates the zonal and eddy available potential energy. In turn, available potential energy is effectively converted to eddy kinetic energy, in which local convective overturning plays the primary role. The magnitude of the intensification effect depends on the initial environmental conditions, including moisture, baroclinity, and the depth of the boundary layer. We conclude that dust radiative forcing, albeit small, serves as a catalyst to promote local convection that facilitates AEW development.

  14. Development of a duplex lateral flow assay for simultaneous detection of antibodies against African and Classical swine fever viruses.

    PubMed

    Sastre, Patricia; Pérez, Teresa; Costa, Sofia; Yang, Xiaoping; Räber, Alex; Blome, Sandra; Goller, Katja V; Gallardo, Carmina; Tapia, Istar; García, Julia; Sanz, Antonio; Rueda, Paloma

    2016-09-01

    Classical swine fever (CSF) and African swine fever (ASF) are both highly contagious diseases of domestic pigs and wild boar and are clinically indistinguishable. For both diseases, antibody detection is an integral and crucial part of prevention and control measures. The purpose of our study was to develop and initially validate a duplex pen-side test for simultaneous detection and differentiation of specific antibodies against CSF virus (CSFV) and ASF virus (ASFV). The test was based on the major capsid protein VP72 of ASFV and the structural protein E2 of CSFV, both considered the most immunogenic proteins of these viruses. The performance of the pen-side test was evaluated using a panel of porcine samples consisting of experimental, reference, and field sera, with the latter collected from European farms free of both diseases. The new lateral flow assay was able to detect specific antibodies to ASFV or CSFV, showing good levels of sensitivity and specificity. These preliminary data indicate the potential of the newly developed pen-side test for rapid differential detection of antibodies found in the 2 diseases, which is of particular importance in the field and in front-line laboratories where equipment and skilled personnel are limited and control of ASF and CSF is crucial. PMID:27400954

  15. Health Care in the Community: Developing Academic/Practice Partnerships for Care Coordination and Managing Transitions.

    PubMed

    Fortier, Mary E; Perron, Tracy; Fountain, Donna M; Hinic, Katherine; Vargas, Maryelena; Swan, Beth Ann; Heelan-Fancher, Lisa

    2015-01-01

    The delivery of health care is quickly changing from an acute care to a community-based setting. Faculty development and mastery in the use of new technologies, such as high-definition simulation and virtual communities are crucial for effective student learning outcomes. Students' benefits include opportunities for hands-on experience in various patient care scenarios, realtime faculty feedback regarding their critical reasoning and clinical performance, interdisciplinary collaboration, and access to a nonthreatening learning environment. The results of this study provide some evidence of the benefits of developing faculty and nursing curricula that addresses the shift from an ilness-based, acute hospital model, to a community and population health-based preventive model. PMID:26259341

  16. Development of a sensor coordinated kinematic model for neural network controller training

    NASA Technical Reports Server (NTRS)

    Jorgensen, Charles C.

    1990-01-01

    A robotic benchmark problem useful for evaluating alternative neural network controllers is presented. Specifically, it derives two camera models and the kinematic equations of a multiple degree of freedom manipulator whose end effector is under observation. The mapping developed include forward and inverse translations from binocular images to 3-D target position and the inverse kinematics of mapping point positions into manipulator commands in joint space. Implementation is detailed for a three degree of freedom manipulator with one revolute joint at the base and two prismatic joints on the arms. The example is restricted to operate within a unit cube with arm links of 0.6 and 0.4 units respectively. The development is presented in the context of more complex simulations and a logical path for extension of the benchmark to higher degree of freedom manipulators is presented.

  17. Simulation of mesogenic diruthenium tetracarboxylates: Development of a force field for coordination polymers of the MMX type.

    PubMed

    Castro, Maria Ana; Roitberg, Adrian E; Cukiernik, Fabio D

    2013-06-01

    A classical molecular mechanics force field, able to simulate coordination polymers (CP) based on ruthenium carboxylates (Ru2 (O2CReq )4 Lax) (eq = equatorial group containing aliphatic chains, Lax = axial ligand), has been developed. New parameters extracted from experimental data and quantum calculations on short aliphatic chains model systems were included in the generalized AMBER force field. The proposed parametrization was evaluated using model systems with known structure, containing either short or long aliphatic chains; experimental results were reproduced satisfactorily. This modified force field, although in a preliminary stage, could then be applied to long chain liquid crystalline compounds. The resulting atomistic simulations allowed assessing the relative influence of the factors determining the CP conformation, determinant for the physical properties of these materials. PMID:23436725

  18. Coordination of tooth morphogenesis and neuronal development through tissue interactions: lessons from mouse models.

    PubMed

    Luukko, Keijo; Kettunen, Päivi

    2014-07-15

    In addition to being an advantageous model to investigate general molecular mechanisms of organ formation, the tooth is a distinct target organ for peripheral nerve innervation. These nerves are required for the function and protection of the teeth and, as shown in fish, also for their regeneration. This review focuses on recent findings of the local tissue interactions and molecular signaling mechanisms that regulate the early nerve arrival and patterning of mouse mandibular molar tooth sensory innervation. Dental sensory nerve growth and patterning is a stepwise process that is intimately linked to advancing tooth morphogenesis. In particular, nerve growth factor and semaphorin 3A serve as essential functions during and are iteratively used at different stages of tooth innervation. The tooth germ controls development of its own nerve supply, and similar to the development of the tooth organ proper, tissue interactions between dental epithelial and mesenchymal tissues control the establishment of tooth innervation. Tgf-β, Wnt, and Fgf signaling, which regulate tooth formation, are implicated to mediate these interactions. Therefore, tissue interactions mediated by conserved signal families may constitute key mechanism for the integration of tooth organogenesis and development of its peripheral nerve supply.

  19. Transforming Growth Factors β Coordinate Cartilage and Tendon Differentiation in the Developing Limb Mesenchyme*

    PubMed Central

    Lorda-Diez, Carlos I.; Montero, Juan A.; Martinez-Cue, Carmen; Garcia-Porrero, Juan A.; Hurle, Juan M.

    2009-01-01

    Transforming growth factor β (TGFβ) signaling has an increasing interest in regenerative medicine as a potential tool to repair cartilages, however the chondrogenic effect of this pathway in developing systems is controversial. Here we have analyzed the function of TGFβ signaling in the differentiation of the developing limb mesoderm in vivo and in high density micromass cultures. In these systems highest signaling activity corresponded with cells at stages preceding overt chondrocyte differentiation. Interestingly treatments with TGFβs shifted the differentiation outcome of the cultures from chondrogenesis to fibrogenesis. This phenotypic reprogramming involved down-regulation of Sox9 and Aggrecan and up-regulation of Scleraxis, and Tenomodulin through the Smad pathway. We further show that TGFβ signaling up-regulates Sox9 in the in vivo experimental model system in which TGFβ treatments induce ectopic chondrogenesis. Looking for clues explaining the dual role of TGFβ signaling, we found that TGFβs appear to be direct inducers of the chondrogenic gene Sox9, but the existence of transcriptional repressors of TGFβ signaling modulates this role. We identified TGF-interacting factor Tgif1 and SKI-like oncogene SnoN as potential candidates for this inhibitory function. Tgif1 gene regulation by TGFβ signaling correlated with the differential chondrogenic and fibrogenic effects of this pathway, and its expression pattern in the limb marks the developing tendons. In functional experiments we found that Tgif1 reproduces the profibrogenic effect of TGFβ treatments. PMID:19717568

  20. Co-ordinated ocular development from human iPS cells and recovery of corneal function.

    PubMed

    Hayashi, Ryuhei; Ishikawa, Yuki; Sasamoto, Yuzuru; Katori, Ryosuke; Nomura, Naoki; Ichikawa, Tatsuya; Araki, Saori; Soma, Takeshi; Kawasaki, Satoshi; Sekiguchi, Kiyotoshi; Quantock, Andrew J; Tsujikawa, Motokazu; Nishida, Kohji

    2016-03-17

    The eye is a complex organ with highly specialized constituent tissues derived from different primordial cell lineages. The retina, for example, develops from neuroectoderm via the optic vesicle, the corneal epithelium is descended from surface ectoderm, while the iris and collagen-rich stroma of the cornea have a neural crest origin. Recent work with pluripotent stem cells in culture has revealed a previously under-appreciated level of intrinsic cellular self-organization, with a focus on the retina and retinal cells. Moreover, we and others have demonstrated the in vitro induction of a corneal epithelial cell phenotype from pluripotent stem cells. These studies, however, have a single, tissue-specific focus and fail to reflect the complexity of whole eye development. Here we demonstrate the generation from human induced pluripotent stem cells of a self-formed ectodermal autonomous multi-zone (SEAM) of ocular cells. In some respects the concentric SEAM mimics whole-eye development because cell location within different zones is indicative of lineage, spanning the ocular surface ectoderm, lens, neuro-retina, and retinal pigment epithelium. It thus represents a promising resource for new and ongoing studies of ocular morphogenesis. The approach also has translational potential and to illustrate this we show that cells isolated from the ocular surface ectodermal zone of the SEAM can be sorted and expanded ex vivo to form a corneal epithelium that recovers function in an experimentally induced animal model of corneal blindness.

  1. IVS Technology Coordinator Report

    NASA Technical Reports Server (NTRS)

    Whitney, Alan

    2013-01-01

    This report of the Technology Coordinator includes the following: 1) continued work to implement the new VLBI2010 system, 2) the 1st International VLBI Technology Workshop, 3) a VLBI Digital- Backend Intercomparison Workshop, 4) DiFX software correlator development for geodetic VLBI, 5) a review of progress towards global VLBI standards, and 6) a welcome to new IVS Technology Coordinator Bill Petrachenko.

  2. Fear of Neighborhood Violence During Adolescence Predicts Development of Obesity a Decade Later: Gender Differences Among African Americans

    PubMed Central

    Assari, Shervin; Moghani Lankarani, Maryam; Caldwell, Cleopatra Howard; Zimmerman, Marc A

    2016-01-01

    Background African American youth are more likely than other racial and ethnic groups to be obese. African American youth are also more likely to live in disadvantaged neighborhoods which increase their victimization, observation, and fear of violence. Objectives This study tested if victimization, observation, and fear of violence in the neighborhood during adolescence predict trajectory of body mass index (BMI) in the 3rd decade of life in African Americans. Patients and Methods Data came from an 18-year community-based cohort. We used multi-group latent growth curve modeling for data analysis, considering neighborhood violence at age 15 (i.e. victimization, observation, and fear) as predictors, and the linear slope for the average change in BMI from age 21 to 32 as the outcome, with age and socioeconomic status (i.e. intact family and parental employment) as covariates. Results Fear of neighborhood violence at age 15 was predictive of an increase in BMI from age 21 to 32 among female but not male African Americans. Victimization and observation of violence at age 15 did not predict BMI change from age 21 to 32 among female or male African Americans. Conclusions Fear of neighborhood violence is a contributing factor to increased risk of obesity for female African American youth who live in disadvantaged areas. This finding has implications for prevention of obesity among African American women who are at highest risk for obesity in the United States. Initiatives that enhance neighborhood safety are critical strategies for obesity prevention among African American women. PMID:27679791

  3. Technology coordination

    NASA Technical Reports Server (NTRS)

    Hartman, Steven

    1992-01-01

    Viewgraphs on technology coordination are provided. Topics covered include: technology coordination process to date; goals; how the Office of Aeronautics and Space Technology (OAST) can support the Office of Space Science and Applications (OSSA); how OSSA can support OAST; steps to technology transfer; and recommendations.

  4. African Centered Knowledge: A British Perspective.

    ERIC Educational Resources Information Center

    Christian, Mark

    2001-01-01

    Considers the impact of African centered knowledge within the United Kingdom. Recent development of African Diaspora studies has forged links between various black Atlantic communities. The United Kingdom has experienced positive grassroots community response to the work of noted African centered scholars, yet within the British academy,…

  5. Revisiting a "study of moral development in the South African context" by Smith and Parekh.

    PubMed

    Snarey, J; Keljo, K

    1996-12-01

    Smith and Parekh's 1996 study underscored the importance of studying the influence of racism upon moral development. Alternative interpretations of their findings suggest fruitful directions for research.

  6. Internet Use in the Developing World: A Case Study of an African University

    ERIC Educational Resources Information Center

    Poda, Ibrahim; Murry, John W., Jr.; Miller, Michael T.

    2006-01-01

    The internet has become an indispensable tool in the twenty first century. However, the development may be slowed by a lack of appropriate facilities in less developed nations. A study of existing facilities in Burkina Faso was undertaken to answer five questions on the participants' perspectives on internet usage: (a) how do the participants…

  7. University as Regional Development Agent: A Counterfactual Analysis of an African University

    ERIC Educational Resources Information Center

    Fongwa, Samuel N.; Wangenge-Ouma, Gerald

    2015-01-01

    The contribution of universities to regional development has in the last few decades gained significant currency. Inter alia, this contribution has been through steered national, regional, and institutional policies aimed at enhancing national development, good governance, human capital creation and innovation in an increasing knowledge-dependent…

  8. Challenges to African Development: The Medium of Instruction in Uganda's Education System

    ERIC Educational Resources Information Center

    Mulumba, Mathias Bwanika; Masaazi, Fred Masagazi

    2012-01-01

    Education, whether formal or informal, is perceived as development and language is the major medium of instruction and communication through which knowledge is transmitted. Documented substantial evidence indicates that Africa was on a positive trend to steady development before colonialism set in. Colonialism ushered in a foreign medium of…

  9. Racial Identity and the Development of Body Image Issues among African American Adolescent Girls

    ERIC Educational Resources Information Center

    Hesse-Biber, Sharlene Nagy; Howling, Stephanie A.; Leavy, Patricia; Lovejoy, Meg

    2004-01-01

    This study focuses on the impact of race, and its intersection with gender, in influencing and/or preventing the development of disordered body image. Specifically, Black samples are examined to see the role that racial identity plays in the process of developing such attitudes. Using qualitative data analysis methods rooted in grounded theory,…

  10. Community and Parent Involvement in Early Childhood Development: The South African Experience.

    ERIC Educational Resources Information Center

    Atmore, Eric; And Others

    Noting that disadvantaged communities in South Africa can be empowered by involving parents and communities in the development of preschool education programs, this report presents the achievements of South Africa's Early Childhood Education and Care (educare) programs. Educare aims to develop the young child's potential to be a meaningful part of…

  11. Private Schooling in Less Economically Developed Countries: Asian and African Perspectives

    ERIC Educational Resources Information Center

    Srivastava, Prachi, Ed.; Walford, Geoffrey, Ed.

    2007-01-01

    The increased marketisation and privatisation of schooling in economically developing countries struggling to achieve Education for All and Millennium Development Goals warrants a focused examination of the phenomenon. However, there is little work on the nature and extent of private provision in countries that, on the one hand, are striving to…

  12. Effects of 17alpha-methyltestosterone on seminal vesicle development and semen release response in the African catfish, Clarias gariepinus.

    PubMed

    Viveiros, A T; Eding, E H; Komen, J

    2001-11-01

    The effects of 17alpha-methyltestosterone on seminal vesicle development in the African catfish, Clarias gariepinus, were investigated in an attempt to improve semen collection from this species. Treatment of larvae with dietary 17alpha-methyltestosterone at 50 mg kg(-1) for days 12-33 or days 12-40 after hatching, or at 20 mg kg(-1) for days 12-26, 12-33, 12-40 or 12-47 after hatching inhibited the development of the seminal vesicle finger-like extensions in male catfish, but did not affect the sex ratio. The minimum effective dose and period of treatment to inhibit seminal vesicle development in all male catfish treated with 17alpha-methyltestosterone was 20 mg kg(-1) for days 12-40 after hatching. Male catfish from this treatment group developed normal testes that, in some cases, contained a few oocytes, which tended to disappear before sexual maturation. After sexual maturation, the semen release response was evaluated in males with incomplete seminal vesicles. Fluid with viable spermatozoa was obtained after two consecutive injections of carp pituitary suspension, from 10 of 19 males that had been fed 20 mg 17alpha-methyltestosterone kg(-1) for days 12-40 or days 12-47 after hatching, but from only 4 of 15 males that did not receive any dietary steroid. Intratesticular semen quality was not affected by 17alpha-methyltestosterone treatment. The results of this study demonstrate that the absence of seminal vesicle extensions induced by treatment with 17alpha-methyltestosterone facilitated the collection of semen by stripping from this species of fish.

  13. Extent of East-african nurse leaders' participation in health policy development.

    PubMed

    Shariff, N; Potgieter, E

    2012-01-01

    This paper reports part of a bigger study whose aim was to develop an empowerment model that could be used to enhance nurse leaders' participation in health policy development. A Delphi survey was applied which included the following criteria: expert panelists, iterative rounds, statistical analysis, and consensus building. The expert panelists were purposively selected and included national nurse leaders in leadership positions at the nursing professional associations, nursing regulatory bodies, ministries of health, and universities in East Africa. The study was conducted in three iterative rounds. The results reported here were gathered as part of the first round of the study and that examined the extent of nurse leaders' participation in health policy development. Seventy-eight (78) expert panelists were invited to participate in the study, and the response rate was 47%. Data collection was done with the use of a self-report questionnaire. Data analysis was done by use of SPSS and descriptive statistics were examined. The findings indicated that nurse leaders participate in health policy development though participation is limited and not consistent across all the stages of health policy development. The recommendations from the findings are that health policy development process needs to be pluralistic and inclusive of all nurse leaders practicing in positions related to policy development and the process must be open to their ideas and suggestions.

  14. History of the development of the East African Rift System: A series of interpreted maps through time

    NASA Astrophysics Data System (ADS)

    Macgregor, Duncan

    2015-01-01

    This review paper presents a series of time reconstruction maps of the 'East African Rift System' ('EARS'), illustrating the progressive development of fault trends, subsidence, volcanism and topography. These maps build on previous basin specific interpretations and integrate released data from recent petroleum drilling. N-S trending EARS rifting commenced in the petroliferous South Lokichar Basin of northern Kenya in the Late Eocene to Oligocene, though there seem to be few further deep rifts of this age other than those immediately adjoining it. At various times during the Mid-Late Miocene, a series of small rifts and depressions formed between Ethiopia and Malawi, heralding the main regional rift subsidence phase and further rift propagation in the Plio-Pleistocene. A wide variation is thus seen in the ages of initiation of EARS basins, though the majority of fault activity, structural growth, subsidence, and associated uplift of East Africa seem to have occurred in the last 5-9 Ma, and particularly in the last 1-2 Ma. These perceptions are key to our understanding of the influence of the diverse tectonic histories on the petroleum prospectivity of undrilled basins.

  15. A population genetic database of cat breeds developed in coordination with a domestic cat STR multiplex.

    PubMed

    Menotti-Raymond, Marilyn; David, Victor A; Weir, Bruce S; O'Brien, Stephen J

    2012-05-01

    A simple tandem repeat (STR) PCR-based typing system developed for the genetic individualization of domestic cat samples has been used to generate a population genetic database of domestic cat breeds. A panel of 10 tetranucleotide STR loci and a gender-identifying sequence tagged site (STS) were co-amplified in genomic DNA of 1043 individuals representing 38 cat breeds. The STR panel exhibits relatively high heterozygosity in cat breeds, with an average 10-locus heterozygosity of 0.71, which represents an average of 38 breed-specific heterozygosities for the 10-member panel. When the entire set of breed individuals was analyzed as a single population, a heterozygosity of 0.87 was observed. Heterozygosities obtained for the 10 loci range from 0.72 to 0.96. The power for genetic individualization of domestic cat samples of the multiplex is high, with a probability of match (p(m)) of 6.2E-14, using a conservative θ = 0.05.

  16. Revisiting a "study of moral development in the South African context" by Smith and Parekh.

    PubMed

    Snarey, J; Keljo, K

    1996-12-01

    Smith and Parekh's 1996 study underscored the importance of studying the influence of racism upon moral development. Alternative interpretations of their findings suggest fruitful directions for research. PMID:8969122

  17. 77 FR 21995 - Trade Facilitation in the East African Community: Recent Developments and Potential Benefits...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-12

    ..., Institution of Investigation and Request for Written Statements AGENCY: United States International Trade Commission. ACTION: Institution of investigation and request for written statements. SUMMARY: Following... Developments and Potential Benefits. DATES: May 10, 2012: Deadline for filing written submissions. July 2,...

  18. Coordination of Division and Development Influences Complex Multicellular Behavior in Agrobacterium tumefaciens

    PubMed Central

    Fuqua, Clay

    2013-01-01

    The α-Proteobacterium Agrobacterium tumefaciens has proteins homologous to known regulators that govern cell division and development in Caulobacter crescentus, many of which are also conserved among diverse α-Proteobacteria. In light of recent work demonstrating similarity between the division cycle of C. crescentus and that of A. tumefaciens, the functional conservation for this presumptive control pathway was examined. In C. crescentus the CtrA response regulator serves as the master regulator of cell cycle progression and cell division. CtrA activity is controlled by an integrated pair of multi-component phosphorelays: PleC/DivJ-DivK and CckA-ChpT-CtrA. Although several of the conserved orthologues appear to be essential in A. tumefaciens, deletions in pleC or divK were isolated and resulted in cell division defects, diminished swimming motility, and a decrease in biofilm formation. A. tumefaciens also has two additional pleC/divJ homologue sensor kinases called pdhS1 and pdhS2, absent in C. crescentus. Deletion of pdhS1 phenocopied the ΔpleC and ΔdivK mutants. Cells lacking pdhS2 morphologically resembled wild-type bacteria, but were decreased in swimming motility and elevated for biofilm formation, suggesting that pdhS2 may serve to regulate the motile to non-motile switch in A. tumefaciens. Genetic analysis suggests that the PleC/DivJ-DivK and CckA-ChpT-CtrA phosphorelays in A. tumefaciens are vertically-integrated, as in C. crescentus. A gain-of-function mutation in CckA (Y674D) was identified as a spontaneous suppressor of the ΔpleC motility phenotype. Thus, although the core architecture of the A. tumefaciens pathway resembles that of C. crescentus there are specific differences including additional regulators, divergent pathway architecture, and distinct target functions. PMID:23437210

  19. Poisson Coordinates.

    PubMed

    Li, Xian-Ying; Hu, Shi-Min

    2013-02-01

    Harmonic functions are the critical points of a Dirichlet energy functional, the linear projections of conformal maps. They play an important role in computer graphics, particularly for gradient-domain image processing and shape-preserving geometric computation. We propose Poisson coordinates, a novel transfinite interpolation scheme based on the Poisson integral formula, as a rapid way to estimate a harmonic function on a certain domain with desired boundary values. Poisson coordinates are an extension of the Mean Value coordinates (MVCs) which inherit their linear precision, smoothness, and kernel positivity. We give explicit formulas for Poisson coordinates in both continuous and 2D discrete forms. Superior to MVCs, Poisson coordinates are proved to be pseudoharmonic (i.e., they reproduce harmonic functions on n-dimensional balls). Our experimental results show that Poisson coordinates have lower Dirichlet energies than MVCs on a number of typical 2D domains (particularly convex domains). As well as presenting a formula, our approach provides useful insights for further studies on coordinates-based interpolation and fast estimation of harmonic functions.

  20. Rhythmic motor activity and interlimb co-ordination in the developing pouch young of a wallaby (Macropus eugenii).

    PubMed Central

    Ho, S M

    1997-01-01

    1. The forelimb motor behaviour of developing wallaby was studied. A clock-like alternating movement was reactivated whenever the animal was removed from the pouch. 2. Forelimb stepping frequency increased during the first 3 weeks of development, while the phase relationship remained constant. Forelimb activity could be affected by altering the afferent feedback from the contralateral limb, or an increase in ambient temperature. 3. In vitro experiments were performed using an isolated brainstem-spinal cord preparation from animals up to 6 weeks postnatal. Fictive locomotor activity could be evoked by electrical stimulation or bath-applied NMDA (< 10 microM). 4. Bath-applied strychnine (10-25 microM) and bicuculline (10-50 microM) disrupted the phase relationship between motor pools, while rhythmic motor discharge remained in the absence of these inhibitory pathways. 5. The present findings indicate that the pattern generator that underlies the robust forelimb movement during the first journey to the pouch is retained for different motor functions during in-pouch development. The neural network that underlies such behaviour can be divided into two major components, a rhythm generator within each hemicord, and a pattern co-ordinating pathway which involve both glycinergic and GABAergic interneurones. PMID:9218221

  1. Coordination of precision grip in 2-6 years-old children with autism spectrum disorders compared to children developing typically and children with developmental disabilities.

    PubMed

    David, Fabian J; Baranek, Grace T; Wiesen, Chris; Miao, Adrienne F; Thorpe, Deborah E

    2012-01-01

    Impaired motor coordination is prevalent in children with Autism Spectrum Disorders (ASD) and affects adaptive skills. Little is known about the development of motor patterns in young children with ASD between 2 and 6 years of age. The purpose of the current study was threefold: (1) to describe developmental correlates of motor coordination in children with ASD, (2) to identify the extent to which motor coordination deficits are unique to ASD by using a control group of children with other developmental disabilities (DD), and (3) to determine the association between motor coordination variables and functional fine motor skills. Twenty-four children with ASD were compared to 30 children with typical development (TD) and 11 children with DD. A precision grip task was used to quantify and analyze motor coordination. The motor coordination variables were two temporal variables (grip to load force onset latency and time to peak grip force) and two force variables (grip force at onset of load force and peak grip force). Functional motor skills were assessed using the Fine Motor Age Equivalents of the Vineland Adaptive Behavior Scale and the Mullen Scales of Early Learning. Mixed regression models were used for all analyses. Children with ASD presented with significant motor coordination deficits only on the two temporal variables, and these variables differentiated children with ASD from the children with TD, but not from children with DD. Fine motor functional skills had no statistically significant associations with any of the motor coordination variables. These findings suggest that subtle problems in the timing of motor actions, possibly related to maturational delays in anticipatory feed-forward mechanisms, may underlie some motor deficits reported in children with ASD, but that these issues are not unique to this population. Further research is needed to investigate how children with ASD or DD compensate for motor control deficits to establish functional skills.

  2. Expression and Sequence Evolution of Aromatase cyp19a1 and Other Sexual Development Genes in East African Cichlid Fishes

    PubMed Central

    Böhne, Astrid; Heule, Corina; Boileau, Nicolas; Salzburger, Walter

    2013-01-01

    Sex determination mechanisms are highly variable across teleost fishes and sexual development is often plastic. Nevertheless, downstream factors establishing the two sexes are presumably conserved. Here, we study sequence evolution and gene expression of core genes of sexual development in a prime model system in evolutionary biology, the East African cichlid fishes. Using the available five cichlid genomes, we test for signs of positive selection in 28 genes including duplicates from the teleost whole-genome duplication, and examine the expression of these candidate genes in three cichlid species. We then focus on a particularly striking case, the A- and B-copies of the aromatase cyp19a1, and detect different evolutionary trajectories: cyp19a1A evolved under strong positive selection, whereas cyp19a1B remained conserved at the protein level, yet is subject to regulatory changes at its transcription start sites. Importantly, we find shifts in gene expression in both copies. Cyp19a1 is considered the most conserved ovary-factor in vertebrates, and in all teleosts investigated so far, cyp19a1A and cyp19a1B are expressed in ovaries and the brain, respectively. This is not the case in cichlids, where we find new expression patterns in two derived lineages: the A-copy gained a novel testis-function in the Ectodine lineage, whereas the B-copy is overexpressed in the testis of the speciest-richest cichlid group, the Haplochromini. This suggests that even key factors of sexual development, including the sex steroid pathway, are not conserved in fish, supporting the idea that flexibility in sexual determination and differentiation may be a driving force of speciation. PMID:23883521

  3. Participation of South African youth in the design and development of AIDS photocomics. 1997-98.

    PubMed

    Toroyan, Tamitza; Reddy, Priscilla S

    In response to an increasing incidence in HIV prevalence among South Africa's youth, a group of interdisciplinary professionals have developed a series of photocomics to address issues around HIV/AIDS communication and sexually transmitted diseases. This article examines the theory behind the use of photocomics in health, and the way the stories work to influence behavior. Results from evaluation of the comics support their use as tools with which to increase information and knowledge while role modeling desirable behavior. Lastly, the article describes the participatory process by which youth were involved in the process of developing and producing the comics. This method of developing culturally relevant and appealing health media is recommended for use in future health promotion strategies that seek to transcend a narrower approach of provision of health information and work to address the social factors that influence youth's decision making.

  4. The human immunodeficiency virus and the cardiometabolic syndrome in the developing world: an African perspective.

    PubMed

    Mutimura, Eugene; Crowther, Nigel J; Stewart, Aimee; Cade, W Todd

    2008-01-01

    The advent of highly active antiretroviral therapy (HAART) has transformed human immunodeficiency virus (HIV)/AIDS into a manageable chronic disorder. Clinical care, however, needs to address the metabolic, anthropometric, and cardiovascular changes associated with HIV infection and HAART. Studies in developing countries suggest an increasing incidence of HIV-associated cardiometabolic syndrome (CMS), especially in urban settings. Predictions indicate that the greatest increase in the prevalence of diabetes will occur in Africa over the next 2 decades due to lifestyle changes. This, coupled with increased access to HAART, may exponentially increase the prevalence of CMS in developing countries, where HIV infection is prevalent. Appropriate evaluation and intervention programs need to be implemented in the developing world, especially sub-Saharan Africa, to curtail HIV-related CMS. This should include routine cardiovascular risk assessments, management of HIV infection with more "metabolically friendly" HAART, and encouragement of lifestyle modifications, particularly smoking cessation, weight management, regular exercise, and adherence to a healthy diet.

  5. The Story of a Library: Research and Development in an African Village

    ERIC Educational Resources Information Center

    Parry, Kate

    2009-01-01

    Background: Although education in Africa is expanding, little is being done to support learners' literacy outside the school. Rural people have little access to books and so cannot develop their reading skills. Purpose of Study: The project described here has both an educational and a research purpose: to complement formal schooling by making…

  6. Information Access in Niger: Development of a West African Special Library.

    ERIC Educational Resources Information Center

    Baldwin, Charlene M.; Varady, Robert G.

    1989-01-01

    Description of a program sponsored by the University of Arizona's Office of Arid Land Studies to improve management of information resources of the Ministry of Planning of Niger covers: (1) assessment of existing services; (2) operational policy development; (3) implementation of a computerized cataloging system; (4) the organizational plan; and…

  7. Life-Wide Learning and Early Reading Development in Twelve African and Asian Sites

    ERIC Educational Resources Information Center

    Dowd, Amy Jo; Friedlander, Elliott; Jonason, Christine; Leer, Jane; Sorensen, Lisa Zook; D'Sa, Nikhit; Guajardo, Jarret; Pava, Clara; Pisani, Lauren

    2016-01-01

    For decades, the international education community has focused on schools as the primary vehicle of learning. However, learning assessments in dozens of developing nations show that repeated attempts to affect student learning in schools have largely failed. Because students with perfect attendance in low-resource settings spend less than 25…

  8. Succession Planning and Leadership Development for School Principals: Comparing English and South African Approaches

    ERIC Educational Resources Information Center

    Bush, Tony

    2011-01-01

    Succession planning has become increasingly important because of the shortage of headship applicants in England, and in many other countries. Leadership development is a central part of any succession planning strategy. This article compares the findings from two longitudinal studies, in England and South Africa, where the governments are seeking…

  9. Import Dependent Technology and the Dilemma of Development among Independent African Nations.

    ERIC Educational Resources Information Center

    Musa, M. B.

    1985-01-01

    The author notes that there is nothing intrinsically wrong with the importation of technology but that development based on such a policy should take cognizance of at least the following two fundamental questions: (1) What kind of technology? and (2) What is the purpose for which a piece of technology is being imported? (Author/CT)

  10. Reframing Professional Development for South African Schools: An Appreciative Inquiry Approach

    ERIC Educational Resources Information Center

    Steyn, G. M.

    2012-01-01

    Often research on the professional development (PD) of staff is framed within a problem-based context that focuses on the PD-related problems experienced by staff. This study pursued a different approach by using the appreciative inquiry (AI) theoretical perspective to study the positive experiences of staff in respect of PD and their desire to…

  11. Handwriting Manual for Primary Teachers in Somalia. African Studies in Curriculum Development & Evaluation No. 61.

    ERIC Educational Resources Information Center

    Dirie, Mohamed Farah

    Concern over the poor and illegible handwriting of the students in Somalia led to the development of this handwriting manual for primary school teachers to: (1) give teachers guidance in teaching handwriting; (2) help teachers in the methodology of teaching handwriting; (3) let teachers know the easier ways of making cheap and obtainable materials…

  12. Changing Discourses of Academic Development at a South African Technikon 1991 to 2002

    ERIC Educational Resources Information Center

    McKenna, S.

    2003-01-01

    This article considers the discourses used by students, mainstream lecturers and academic development lecturers in their evaluations of language interventions at Technikon Natal from 1991 to 2002. The discourses under scrutiny are those of academic literacy: the beliefs, attitudes, values and norms necessary for "epistemological access to higher…

  13. Challenges and Opportunities for Teacher Professional Development in Interactive Use of Technology in African Schools

    ERIC Educational Resources Information Center

    Hennessy, Sara; Haßler, Bjoern; Hofmann, Riikka

    2015-01-01

    This article examines the supporting and constraining factors influencing professional learning about interactive teaching and mobile digital technology use in low-resourced basic schools in sub-Saharan Africa. It draws on a case study of iterative development and refinement of a school-based, peer-facilitated professional learning programme…

  14. Health Workforce Development: A Needs Assessment Study in French Speaking African Countries

    ERIC Educational Resources Information Center

    Chastonay, Philippe; Moretti, Roberto; Zesiger, Veronique; Cremaschini, Marco; Bailey, Rebecca; Pariyo, George; Kabengele, Emmanuel Mpinga

    2013-01-01

    In 2006, WHO alerted the world to a global health workforce crisis, demonstrated through critical shortages of health workers, primarily in Sub-Saharan Africa (WHO in World Health Report, 2006). The objective of our study was to assess, in a participative way, the educational needs for public health and health workforce development among potential…

  15. Possibilities and pitfalls for modern biotechnology in the development of African genetic toxicology

    SciTech Connect

    Anwar, Wagida A. . E-mail: wagidaanwar@yahoo.com

    2005-09-01

    Developing countries are currently going through a transitional phase facing the new challenges of globalization and its potential negative impact. Research policy should highlight the need to mobilize resources for human resource development, networking, improved research culture, information sharing, and pragmatic use of research findings. Advancement in molecular genetics whether at the educational or research level should greatly progress in developing countries so as to improve diagnosis, treatment, understanding of disease risk factors, and prevention. Currently, there is a growing interest to genetic toxicology research, the use of different biomarkers, and genetic susceptibility testing, which can contribute effectively in risk assessment. Africa has unique environmental exposures and public health circumstances, which make it ideal for environmental mutagenicity and carcinogenicity research. There are exposures to chemical genotoxicants (e.g., automobile exhaust, pesticides, metals, and cytotoxic drugs) and to lifestyle factors (e.g., consumption of tobacco products) that have been linked to the expression of biological effects and to increased risk for cancer. Infections can be associated with cancer development when the environmental factors interact with the infection and lead to the enhancement of the carcinogenic process. The high prevalence of viral pathogens and the improper use of pesticides may endanger biological functions beyond those for which they originally manufactured. Biomarkers are used to detect the effects of pesticides before adverse clinical health occurs. The scientific community plays a crucial role in understanding the environmental causes of human health problems and through its collaboration with communities, industries, and government agencies can help in resolving health problems.

  16. African Early Childhood Development Curriculum and Pedagogy for Turkana Nomadic Pastoralist Communities of Kenya

    ERIC Educational Resources Information Center

    Ng'asike, John T.

    2014-01-01

    Western conceptions of child development and the models of early education they engender predominantly shape services for young children in the first eight years of life all over Africa. This chapter brings a reconceptualist perspective to the critique of Kenya's continuing failure to ground early childhood programs and services in local…

  17. Exploring Blended Learning for Science Teacher Professional Development in an African Context

    ERIC Educational Resources Information Center

    Boitshwarelo, Bopelo

    2009-01-01

    This paper explores a case of teacher professional development in Botswana where a blended learning solution was attempted. The analysis of the implementation environment reveals deficiencies in policy, schools (workplaces), and training providers. The paper concludes with three recommendations: 1) Schools should support ongoing teacher learning…

  18. Leadership Development in South African Higher Education: The Heart of the Matter

    ERIC Educational Resources Information Center

    Zuber-Skerritt, O.

    2007-01-01

    An extensive literature on leadership theories and models concerns large organizations in industry and has been developed mostly by outside researchers with expertise in conducting large surveys on and interviews with "subjects" in leadership positions. Recently, such theories have been adopted or adapted to higher education in South Africa. These…

  19. Institutional Context Matters: The Professional Development of Academics as Teachers in South African Higher Education

    ERIC Educational Resources Information Center

    Leibowitz, Brenda; Bozalek, Vivienne; van Schalkwyk, Susan; Winberg, Christine

    2015-01-01

    This study features the concept of "context" and how various macro, meso and micro features of the social system play themselves out in any setting. Using South Africa as an example, it explores the features that may constrain or enable professional development, quality teaching and the work of teaching and learning centres at eight…

  20. A Comprehensive Competence-Based Approach in Curriculum Development: Experiences from African and European Contexts

    ERIC Educational Resources Information Center

    Parent, F.; Baulana, R.; Kahombo, G.; Coppieters, Y.; Garant, M.; De Ketele, J.-M.

    2011-01-01

    Objective: To describe the methodological steps of developing an integrated reference guide for competences according to the profile of the healthcare professionals concerned. Design: Human resources in healthcare represent a complex issue, which needs conceptual and methodological frameworks and tools to help one understand reality and the limits…

  1. Culture, Indigenous Knowledge Systems and Sustainable Development: A Critical View of Education in an African Context

    ERIC Educational Resources Information Center

    Breidlid, Anders

    2009-01-01

    The article's focus is the relationship between culture, indigenous knowledge systems (IKS), sustainable development and education in Africa. It analyzes the concept of sustainability with particular reference to education and indigenous knowledge systems. In particular the article analyzes the documents from the World Summit in Johannesburg in…

  2. The Development of Higher Education and Social Change: An Ethiopian Experience. African Series 2.

    ERIC Educational Resources Information Center

    Wagaw, Teshome G.

    This book describes the development of institutions of higher education in Ethiopia and the roles they played in the transformation of traditional Ethiopian society. It shows that although other modernizing agencies such as a standing army, parliament, trade unions, and lower institutions of learning may play significant roles in social and…

  3. Rapid Development of gp120-Focused Neutralizing B Cell Responses during Acute Simian Immunodeficiency Virus Infection of African Green Monkeys

    PubMed Central

    Amos, Joshua D.; Himes, Jonathon E.; Armand, Lawrence; Gurley, Thaddeus C.; Martinez, David R.; Colvin, Lisa; Beck, Krista; Overman, R. Glenn; Liao, Hua-Xin; Moody, M. Anthony

    2015-01-01

    ABSTRACT The initial phases of acute human immunodeficiency virus type 1 (HIV-1) infection may be critical for development of effective envelope (Env)-specific antibodies capable of impeding the establishment of the latent pool of HIV-1-infected CD4+ T cells, preventing virus-induced immune hyperactivation to limit disease progression and blocking vertical virus transmission. However, the initial systemic HIV-1 Env-specific antibody response targets gp41 epitopes and fails to control acute-phase viremia. African-origin, natural simian immunodeficiency virus (SIV) hosts do not typically progress to AIDS and rarely postnatally transmit virus to their infants, despite high milk viral loads. Conversely, SIV-infected rhesus macaques (RMs), Asian-origin nonnatural SIV hosts, sustain pathogenic SIV infections and exhibit higher rates of postnatal virus transmission. In this study, of acute SIV infection, we compared the initial systemic Env-specific B cell responses of AGMs and RMs in order to probe potential factors influencing the lack of disease progression observed in AGMs. AGMs developed higher-magnitude plasma gp120-specific IgA and IgG responses than RMs, whereas RMs developed more robust gp140-directed IgG responses. These gp120-focused antibody responses were accompanied by rapid autologous neutralizing responses during acute SIV infection in AGMs compared to RMs. Moreover, acute SIV infection elicited a higher number of circulating Env-specific memory B cells in peripheral blood of AGMs than in the blood of RMs. These findings indicate that AGMs have initial systemic Env-specific B cell responses to SIV infection distinct from those of a nonnatural SIV host, resulting in more functional SIV-specific humoral responses, which may be involved in impairing pathogenic disease progression and minimizing postnatal transmission. IMPORTANCE Due to the worldwide prevalence of HIV-1 infections, development of a vaccine to prevent infection or limit the viral reservoir

  4. Development of an Experimental African Drought Monitoring and Seasonal Forecasting System: A First Step towards a Global Drought Information System

    NASA Astrophysics Data System (ADS)

    Wood, E. F.; Chaney, N.; Sheffield, J.; Yuan, X.

    2012-12-01

    Extreme hydrologic events in the form of droughts are a significant source of social and economic damage. Internationally, organizations such as UNESCO, the Group on Earth Observations (GEO), and the World Climate Research Programme (WCRP) have recognized the need for drought monitoring, especially for the developing world where drought has had devastating impacts on local populations through food insecurity and famine. Having the capacity to monitor droughts in real-time, and to provide drought forecasts with sufficient warning will help developing countries and international programs move from the management of drought crises to the management of drought risk. While observation-based assessments, such as those produced by the US Drought Monitor, are effective for monitoring in countries with extensive observation networks (of precipitation in particular), their utility is lessened in areas (e.g., Africa) where observing networks are sparse. For countries with sparse networks and weak reporting systems, remote sensing observations can provide the real-time data for the monitoring of drought. More importantly, these datasets are now available for at least a decade, which allows for the construction of a climatology against which current conditions can be compared. In this presentation we discuss the development of our multi-lingual experimental African Drought Monitor (ADM) (see http://hydrology.princeton.edu/~nchaney/ADM_ML). At the request of UNESCO, the ADM system has been installed at AGRHYMET, a regional climate and agricultural center in Niamey, Niger and at the ICPAC climate center in Nairobi, Kenya. The ADM system leverages off our U.S. drought monitoring and forecasting system (http://hydrology.princeton.edu/forecasting) that uses the NLDAS data to force the VIC land surface model (LSM) at 1/8th degree spatial resolution for the estimation of our soil moisture drought index (Sheffield et al., 2004). For the seasonal forecast of drought, CFSv2 climate

  5. GHG emission factors developed for the recycling and composting of municipal waste in South African municipalities.

    PubMed

    Friedrich, Elena; Trois, Cristina

    2013-11-01

    GHG (greenhouse gas) emission factors for waste management are increasingly used, but such factors are very scarce for developing countries. This paper shows how such factors have been developed for the recycling of glass, metals (Al and Fe), plastics and paper from municipal solid waste, as well as for the composting of garden refuse in South Africa. The emission factors developed for the different recyclables in the country show savings varying from -290kg CO2 e (glass) to -19111kg CO2 e (metals - Al) per tonne of recyclable. They also show that there is variability, with energy intensive materials like metals having higher GHG savings in South Africa as compared to other countries. This underlines the interrelation of the waste management system of a country/region with other systems, in particular with energy generation, which in South Africa, is heavily reliant on coal. This study also shows that composting of garden waste is a net GHG emitter, releasing 172 and 186kg CO2 e per tonne of wet garden waste for aerated dome composting and turned windrow composting, respectively. The paper concludes that these emission factors are facilitating GHG emissions modelling for waste management in South Africa and enabling local municipalities to identify best practice in this regard.

  6. A Complex Regulatory Network Coordinating Cell Cycles During C. elegans Development Is Revealed by a Genome-Wide RNAi Screen

    PubMed Central

    Roy, Sarah H.; Tobin, David V.; Memar, Nadin; Beltz, Eleanor; Holmen, Jenna; Clayton, Joseph E.; Chiu, Daniel J.; Young, Laura D.; Green, Travis H.; Lubin, Isabella; Liu, Yuying; Conradt, Barbara; Saito, R. Mako

    2014-01-01

    The development and homeostasis of multicellular animals requires precise coordination of cell division and differentiation. We performed a genome-wide RNA interference screen in Caenorhabditis elegans to reveal the components of a regulatory network that promotes developmentally programmed cell-cycle quiescence. The 107 identified genes are predicted to constitute regulatory networks that are conserved among higher animals because almost half of the genes are represented by clear human orthologs. Using a series of mutant backgrounds to assess their genetic activities, the RNA interference clones displaying similar properties were clustered to establish potential regulatory relationships within the network. This approach uncovered four distinct genetic pathways controlling cell-cycle entry during intestinal organogenesis. The enhanced phenotypes observed for animals carrying compound mutations attest to the collaboration between distinct mechanisms to ensure strict developmental regulation of cell cycles. Moreover, we characterized ubc-25, a gene encoding an E2 ubiquitin-conjugating enzyme whose human ortholog, UBE2Q2, is deregulated in several cancers. Our genetic analyses suggested that ubc-25 acts in a linear pathway with cul-1/Cul1, in parallel to pathways employing cki-1/p27 and lin-35/pRb to promote cell-cycle quiescence. Further investigation of the potential regulatory mechanism demonstrated that ubc-25 activity negatively regulates CYE-1/cyclin E protein abundance in vivo. Together, our results show that the ubc-25-mediated pathway acts within a complex network that integrates the actions of multiple molecular mechanisms to control cell cycles during development. PMID:24584095

  7. A Drosophila XPD model links cell cycle coordination with neuro-development and suggests links to cancer

    PubMed Central

    Stettler, Karin; Li, Xiaoming; Sandrock, Björn; Braga-Lagache, Sophie; Heller, Manfred; Dümbgen, Lutz; Suter, Beat

    2015-01-01

    XPD functions in transcription, DNA repair and in cell cycle control. Mutations in human XPD (also known as ERCC2) mainly cause three clinical phenotypes: xeroderma pigmentosum (XP), Cockayne syndrome (XP/CS) and trichothiodystrophy (TTD), and only XP patients have a high predisposition to developing cancer. Hence, we developed a fly model to obtain novel insights into the defects caused by individual hypomorphic alleles identified in human XP-D patients. This model revealed that the mutations that displayed the greatest in vivo UV sensitivity in Drosophila did not correlate with those that led to tumor formation in humans. Immunoprecipitations followed by targeted quantitative MS/MS analysis showed how different xpd mutations affected the formation or stability of different transcription factor IIH (TFIIH) subcomplexes. The XP mutants most clearly linked to high cancer risk, Xpd R683W and R601L, showed a reduced interaction with the core TFIIH and also an abnormal interaction with the Cdk-activating kinase (CAK) complex. Interestingly, these two XP alleles additionally displayed high levels of chromatin loss and free centrosomes during the rapid nuclear division phase of the Drosophila embryo. Finally, the xpd mutations showing defects in the coordination of cell cycle timing during the Drosophila embryonic divisions correlated with those human mutations that cause the neurodevelopmental abnormalities and developmental growth defects observed in XP/CS and TTD patients. PMID:25431422

  8. Development of a probing system for a micro-coordinate measuring machine by utilizing shear-force detection

    NASA Astrophysics Data System (ADS)

    Ito, So; Kodama, Issei; Gao, Wei

    2014-06-01

    This paper introduces a newly developed probing system for a micro-coordinate measurement machine (micro-CMM) based on an interaction force generated by the water layer on the surface of the measuring object. In order to measure the dimensions of the micrometric structures, a probing system using a nanopipette ball stylus has been developed. A glass microsphere with diameter of 9 µm is used as a stylus tip of the probing system. The glass nanopipette, which is fabricated from a capillary glass tube by a thermal pulling process, is employed as a stylus shaft to improve the fixation strength of the stylus tip. The approach between the stylus tip and the surface of the measuring object can be detected by utilizing the method of shear-force detection. The stylus is oscillated in the lateral direction at its resonant frequency to detect an interaction force owing to the viscoelasticity of the meniscus layer existing on the surface of the measuring object. The oscillation amplitude is decreased by the shear-force applied to the stylus tip. In this study, the basic characteristics of the probing system including sensitivity, resolution and reproducibility are investigated. The experimental result of dimensional measurement of micrometer-scale structure is presented.

  9. VP2 Exchange and NS3/NS3a Deletion in African Horse Sickness Virus (AHSV) in Development of Disabled Infectious Single Animal Vaccine Candidates for AHSV

    PubMed Central

    van de Water, Sandra G. P.; van Gennip, René G. P.; Potgieter, Christiaan A.; Wright, Isabel M.

    2015-01-01

    ABSTRACT African horse sickness virus (AHSV) is a virus species in the genus Orbivirus of the family Reoviridae. There are nine serotypes of AHSV showing different levels of cross neutralization. AHSV is transmitted by species of Culicoides biting midges and causes African horse sickness (AHS) in equids, with a mortality rate of up to 95% in naive horses. AHS has become a serious threat for countries outside Africa, since endemic Culicoides species in moderate climates appear to be competent vectors for the related bluetongue virus (BTV). To control AHS, live-attenuated vaccines (LAVs) are used in Africa. We used reverse genetics to generate “synthetic” reassortants of AHSV for all nine serotypes by exchange of genome segment 2 (Seg-2). This segment encodes VP2, which is the serotype-determining protein and the dominant target for neutralizing antibodies. Single Seg-2 AHSV reassortants showed similar cytopathogenic effects in mammalian cells but displayed different growth kinetics. Reverse genetics for AHSV was also used to study Seg-10 expressing NS3/NS3a proteins. We demonstrated that NS3/NS3a proteins are not essential for AHSV replication in vitro. NS3/NS3a of AHSV is, however, involved in the cytopathogenic effect in mammalian cells and is very important for virus release from cultured insect cells in particular. Similar to the concept of the bluetongue disabled infectious single animal (BT DISA) vaccine platform, an AHS DISA vaccine platform lacking NS3/NS3a expression was developed. Using exchange of genome segment 2 encoding VP2 protein (Seg-2[VP2]), we will be able to develop AHS DISA vaccine candidates for all current AHSV serotypes. IMPORTANCE African horse sickness virus is transmitted by species of Culicoides biting midges and causes African horse sickness in equids, with a mortality rate of up to 95% in naive horses. African horse sickness has become a serious threat for countries outside Africa, since endemic Culicoides species in moderate

  10. Coordinated development. Sichuan province.

    PubMed

    Zhang, J

    1994-03-01

    The director of the Guangyuan Family Planning Commission notes the abject poverty which he observed upon assuming a post in the township hospital in 1967. Many farmers were still very poor in the late 1980s with 44.0% of the residents in Wuangcang County living in poverty. The high birth rate of 26/1000 made many families destitute even after government assistance had already helped them alleviate poverty. The county government realized that linking anti-poverty measures with family planning promotion was needed to help farmers emerge from poverty. The government in 1986 therefore began to provide materials and money to impoverished families with annual income under $70.18 and having less than 500 kilograms of grain for food per year. These families were encouraged to learn more productive farming techniques and advised to practice family planning. A new employment promotion system was also introduced in 1985 to induce farmers from low-output farmland to move into township enterprises. The township began to run coal mines, cement factories, and construction and transportation companies. The total output value of these rural enterprises in 1992 amounted to $5.26 million and absorbed more than 2200 farmers as laborers. A 38-kilometer-long road was also constructed. People's income increased rapidly, they enjoyed higher living standards, and most couples began opting to bear fewer children. PMID:12287773

  11. Development of the Ways Of Helping Questionnaire: a measure of preferred coping strategies for older African American cancer survivors.

    PubMed

    Hamilton, Jill B; Stewart, Barbara J; Crandell, Jamie L; Lynn, Mary R

    2009-06-01

    Although researchers have identified beneficial coping strategies for cancer patients, existing coping measures do not capture the preferred coping strategies of older African American cancer survivors. A new measure, the Ways of Helping Questionnaire (WHQ), was evaluated with 385 African American cancer survivors. Validity evidence from factor analysis resulted in 10 WHQ subscales (Others There for Me, Physical and Treatment Care Needs, Help from God, Church Family Support, Helping Others, Being Strong for Others, Encouraging My Healthy Behaviors, Others Distract Me, Learning about Cancer, and Distracting Myself). Reliability evidence was generally strong. Evidence regarding hypothesized relationships with measures of well-being and another coping measure was mixed. The WHQ's content coverage makes it especially relevant for older African American cancer survivors. PMID:19259991

  12. Development and Validation of a High-Density SNP Genotyping Array for African Oil Palm.

    PubMed

    Kwong, Qi Bin; Teh, Chee Keng; Ong, Ai Ling; Heng, Huey Ying; Lee, Heng Leng; Mohamed, Mohaimi; Low, Joel Zi-Bin; Apparow, Sukganah; Chew, Fook Tim; Mayes, Sean; Kulaveerasingam, Harikrishna; Tammi, Martti; Appleton, David Ross

    2016-08-01

    High-density single nucleotide polymorphism (SNP) genotyping arrays are powerful tools that can measure the level of genetic polymorphism within a population. To develop a whole-genome SNP array for oil palms, SNP discovery was performed using deep resequencing of eight libraries derived from 132 Elaeis guineensis and Elaeis oleifera palms belonging to 59 origins, resulting in the discovery of >3 million putative SNPs. After SNP filtering, the Illumina OP200K custom array was built with 170 860 successful probes. Phenetic clustering analysis revealed that the array could distinguish between palms of different origins in a way consistent with pedigree records. Genome-wide linkage disequilibrium declined more slowly for the commercial populations (ranging from 120 kb at r(2) = 0.43 to 146 kb at r(2) = 0.50) when compared with the semi-wild populations (19.5 kb at r(2) = 0.22). Genetic fixation mapping comparing the semi-wild and commercial population identified 321 selective sweeps. A genome-wide association study (GWAS) detected a significant peak on chromosome 2 associated with the polygenic component of the shell thickness trait (based on the trait shell-to-fruit; S/F %) in tenera palms. Testing of a genomic selection model on the same trait resulted in good prediction accuracy (r = 0.65) with 42% of the S/F % variation explained. The first high-density SNP genotyping array for oil palm has been developed and shown to be robust for use in genetic studies and with potential for developing early trait prediction to shorten the oil palm breeding cycle.

  13. GHG emission factors developed for the recycling and composting of municipal waste in South African municipalities

    SciTech Connect

    Friedrich, Elena Trois, Cristina

    2013-11-15

    Highlights: • GHG emission factors for local recycling of municipal waste are presented. • GHG emission factors for two composting technologies for garden waste are included. • Local GHG emission factors were compared to international ones and discussed. • Uncertainties and limitations are presented and areas for new research highlighted. - Abstract: GHG (greenhouse gas) emission factors for waste management are increasingly used, but such factors are very scarce for developing countries. This paper shows how such factors have been developed for the recycling of glass, metals (Al and Fe), plastics and paper from municipal solid waste, as well as for the composting of garden refuse in South Africa. The emission factors developed for the different recyclables in the country show savings varying from −290 kg CO{sub 2} e (glass) to −19 111 kg CO{sub 2} e (metals – Al) per tonne of recyclable. They also show that there is variability, with energy intensive materials like metals having higher GHG savings in South Africa as compared to other countries. This underlines the interrelation of the waste management system of a country/region with other systems, in particular with energy generation, which in South Africa, is heavily reliant on coal. This study also shows that composting of garden waste is a net GHG emitter, releasing 172 and 186 kg CO{sub 2} e per tonne of wet garden waste for aerated dome composting and turned windrow composting, respectively. The paper concludes that these emission factors are facilitating GHG emissions modelling for waste management in South Africa and enabling local municipalities to identify best practice in this regard.

  14. Development and Validation of a High-Density SNP Genotyping Array for African Oil Palm.

    PubMed

    Kwong, Qi Bin; Teh, Chee Keng; Ong, Ai Ling; Heng, Huey Ying; Lee, Heng Leng; Mohamed, Mohaimi; Low, Joel Zi-Bin; Apparow, Sukganah; Chew, Fook Tim; Mayes, Sean; Kulaveerasingam, Harikrishna; Tammi, Martti; Appleton, David Ross

    2016-08-01

    High-density single nucleotide polymorphism (SNP) genotyping arrays are powerful tools that can measure the level of genetic polymorphism within a population. To develop a whole-genome SNP array for oil palms, SNP discovery was performed using deep resequencing of eight libraries derived from 132 Elaeis guineensis and Elaeis oleifera palms belonging to 59 origins, resulting in the discovery of >3 million putative SNPs. After SNP filtering, the Illumina OP200K custom array was built with 170 860 successful probes. Phenetic clustering analysis revealed that the array could distinguish between palms of different origins in a way consistent with pedigree records. Genome-wide linkage disequilibrium declined more slowly for the commercial populations (ranging from 120 kb at r(2) = 0.43 to 146 kb at r(2) = 0.50) when compared with the semi-wild populations (19.5 kb at r(2) = 0.22). Genetic fixation mapping comparing the semi-wild and commercial population identified 321 selective sweeps. A genome-wide association study (GWAS) detected a significant peak on chromosome 2 associated with the polygenic component of the shell thickness trait (based on the trait shell-to-fruit; S/F %) in tenera palms. Testing of a genomic selection model on the same trait resulted in good prediction accuracy (r = 0.65) with 42% of the S/F % variation explained. The first high-density SNP genotyping array for oil palm has been developed and shown to be robust for use in genetic studies and with potential for developing early trait prediction to shorten the oil palm breeding cycle. PMID:27112659

  15. The history of African trypanosomiasis

    PubMed Central

    Steverding, Dietmar

    2008-01-01

    The prehistory of African trypanosomiasis indicates that the disease may have been an important selective factor in the evolution of hominids. Ancient history and medieval history reveal that African trypanosomiasis affected the lives of people living in sub-Saharan African at all times. Modern history of African trypanosomiasis revolves around the identification of the causative agents and the mode of transmission of the infection, and the development of drugs for treatment and methods for control of the disease. From the recent history of sleeping sickness we can learn that the disease can be controlled but probably not be eradicated. Current history of human African trypanosomiasis has shown that the production of anti-sleeping sickness drugs is not always guaranteed, and therefore, new, better and cheaper drugs are urgently required. PMID:18275594

  16. Coordination of cellular events that precede reproductive onset in Acetabularia acetabulum: evidence for a 'loop' in development.

    PubMed

    Runft, L L; Mandoli, D F

    1996-04-01

    Amputated apices from vegetative wildtype cells of the uninucleate green alga Acetabularia acetabulum can differentiate a reproductive structure of 'cap' in the absence of the nucleus (Hämmerling, J. (1932) Biologisches Zentralblatt 52, 42-61). To define the limits of the ability of wildtype cells to control reproductive differentiation, we determined when during development apices from wildtype cells first acquired the ability to make a cap in the absence of the nucleus and, conversely, when cells with a nucleus lost the ability to recover from the loss of their apices. To see when the apex acquired the ability to make a cap without the nucleus, we removed apices from cells varying either the developmental age of the cells or the cellular volume left with the apex. Cells must have attained the adult phase of development before the enucleate apex could survive amputation and make a cap. Apices removed from cells early in adult growth required more cell volume to make a cap without the nucleus than did apices removed from cells late in adult growth. To define the limits of the cell to recapitulate development when reproduction falters, we analyzed development in cells whose caps either had been amputated or had spontaneously aborted. After loss of the first cap, cells repeated part of vegetative growth and then made a second cap. The ability to make a second cap after amputation of the first one was lost 15-20 days after cap initiation. Our data suggest that internal cues, cell age and size, are used to regulate reproductive onset in Acetabularia acetabulum and add to our understanding of how reproduction is coordinated in this giant cell.

  17. Developing and Evaluating Supplementary Science Readers for Primary 3 Pupils in Uganda. African Studies in Curriculum Development & Evaluation.

    ERIC Educational Resources Information Center

    Kiyimba, David S.

    Five science reading booklets were developed to foster the development of communication, observation, and experimentation skills in Uganda elementary school students. Topics selected, resulting from interviews with teachers and students, included: 1) rain; 2) round worms; 3) caterpillars; 4) butterflies; and 5) insects in the school ground.…

  18. Laboratory Diagnosis of Tick-Borne African Relapsing Fevers: Latest Developments

    PubMed Central

    Fotso Fotso, Aurélien; Drancourt, Michel

    2015-01-01

    In Africa, relapsing fevers caused by ectoparasite-borne Borrelia species are transmitted by ticks, with the exception of Borrelia recurrentis, which is a louse-borne spirochete. These tropical diseases are responsible for mild to deadly spirochetemia. Cultured Borrelia crocidurae, Borrelia duttonii, and Borrelia hispanica circulate alongside at least six species that have not yet been cultured in vectors. Direct diagnosis is hindered by the use of non-specific laboratory tools. Indeed, microscopic observation of Borrelia spirochaeta in smears of peripheral blood taken from febrile patients lacks sensitivity and specificity. Although best visualized using dark-field microscopy, the organisms can also be detected using Wright–Giemsa or acridine orange stains. PCR-based detection of specific sequences in total DNA extracted from a specimen can be used to discriminate different relapsing fever Borreliae. In our laboratory, we developed a multiplex real-time PCR assay for the specific detection of B. duttonii/recurrentis and B. crocidurae: multispacer sequence typing accurately identified cultured relapsing fever borreliae and revealed diversity among them. Other molecular typing techniques, such as multilocus sequence analysis of tick-borne relapsing fever borreliae, showed the potential risk of human infection in Africa. Recent efforts to culture and sequence relapsing fever borreliae have provided new information for reassessment of the diversity of these bacteria. Recently, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry has been reported as a means of identifying cultured borreliae and of identifying both vectors and vectorized pathogens such as detecting relapsing fever borreliae directly in ticks. The lack of a rapid diagnosis test restricts the management of such diseases. We produced monoclonal antibodies against B. crocidurae in order to develop cheap assays for the rapid detection of relapsing fever borreliae. In this paper, we

  19. Pubertal development in HIV-infected African children on first-line antiretroviral therapy

    PubMed Central

    Szubert, Alexander J.; Musiime, Victor; Bwakura-Dangarembizi, Mutsawashe; Nahirya-Ntege, Patricia; Kekitiinwa, Adeodata; Gibb, Diana M.; Nathoo, Kusum; Prendergast, Andrew J.; Walker, A. Sarah

    2015-01-01

    Objectives: To estimate age at attaining Tanner stages in Ugandan/Zimbabwean HIV-infected children initiating antiretroviral therapy (ART) in older childhood and investigate predictors of delayed puberty, particularly age at ART initiation. Design: Observational analysis within a randomized trial. Methods: Tanner staging was assessed every 24 weeks from 10 years of age, menarche every 12 weeks and height every 4–6 weeks. Age at attaining different Tanner stages was estimated using normal interval regression, considering predictors using multivariable regression. Growth was estimated using multilevel models with child-specific intercepts and trajectories. Results: Median age at ART initiation was 9.4 years (inter-quartile range 7.8, 11.3) (n = 582). At the first assessment, the majority (80.2%) were in Tanner stage 1; median follow-up with staging was 2.8 years. There was a strong delaying effect of older age at ART initiation on age at attaining all Tanner stages (P < 0.05) and menarche (P = 0.02); in boys the delaying effect generally weakened with older age. There were additional significant delays associated with greater impairments in pre-ART height-for-age Z-score (P < 0.05) in both sexes and pre-ART BMI-for-age in girls (P < 0.05). There was no evidence that pre-ART immuno-suppression independently delayed puberty or menarche. However, older children/adolescents had significant growth spurts in intermediate Tanner stages, and were still significantly increasing their height when in Tanner stage 5 (P < 0.01). Conclusion: Delaying ART initiation until older childhood substantially delays pubertal development and menarche, independently of immuno-suppression. This highlights that factors other than CD4+, such as pubertal development, need consideration when making decisions about timing of ART initiation in older children. PMID:25710288

  20. Laboratory Diagnosis of Tick-Borne African Relapsing Fevers: Latest Developments.

    PubMed

    Fotso Fotso, Aurélien; Drancourt, Michel

    2015-01-01

    In Africa, relapsing fevers caused by ectoparasite-borne Borrelia species are transmitted by ticks, with the exception of Borrelia recurrentis, which is a louse-borne spirochete. These tropical diseases are responsible for mild to deadly spirochetemia. Cultured Borrelia crocidurae, Borrelia duttonii, and Borrelia hispanica circulate alongside at least six species that have not yet been cultured in vectors. Direct diagnosis is hindered by the use of non-specific laboratory tools. Indeed, microscopic observation of Borrelia spirochaeta in smears of peripheral blood taken from febrile patients lacks sensitivity and specificity. Although best visualized using dark-field microscopy, the organisms can also be detected using Wright-Giemsa or acridine orange stains. PCR-based detection of specific sequences in total DNA extracted from a specimen can be used to discriminate different relapsing fever Borreliae. In our laboratory, we developed a multiplex real-time PCR assay for the specific detection of B. duttonii/recurrentis and B. crocidurae: multispacer sequence typing accurately identified cultured relapsing fever borreliae and revealed diversity among them. Other molecular typing techniques, such as multilocus sequence analysis of tick-borne relapsing fever borreliae, showed the potential risk of human infection in Africa. Recent efforts to culture and sequence relapsing fever borreliae have provided new information for reassessment of the diversity of these bacteria. Recently, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry has been reported as a means of identifying cultured borreliae and of identifying both vectors and vectorized pathogens such as detecting relapsing fever borreliae directly in ticks. The lack of a rapid diagnosis test restricts the management of such diseases. We produced monoclonal antibodies against B. crocidurae in order to develop cheap assays for the rapid detection of relapsing fever borreliae. In this paper, we

  1. Antral follicles develop in xenografted cryopreserved African elephant (Loxodonta africana) ovarian tissue.

    PubMed

    Gunasena, K T; Lakey, J R; Villines, P M; Bush, M; Raath, C; Critser, E S; McGann, L E; Critser, J K

    1998-10-01

    The preservation of germ plasm from endangered species could augment captive breeding programs aimed at maintaining genetic diversity. Mammalian female germ plasm (oocytes) is extremely difficult to collect and cryopreserve; however, a promising alternative is the cryopreservation of ovarian tissue. In the present study, athymic nude (nu/nu) Balb/C mice were used to evaluate in vivo viability of cryopreserved ovarian tissue from Institute of Cancer Research genotype (ICR) mice or elephants. Female mice were ovariectomized prior to transplant of cryopreserved-thawed ovarian tissue from ICR mice (n=4) or elephants (n=6). Control mice were sham operated (n=4) or ovariectomized (n=5). Transplants were in the ovarian bursa, enabling in vivo ovulation and pregnancies from allografts. Vaginal cytology was monitored daily, and the intervals between and duration of epithelial cells present in smears were evaluated. Appearance of epithelial cells in sham-operated and allografted mice were at intervals of 4.3+/-0.6 and 3.3+/-0.5 days, lasting for 1.4+/-0.1 and 1.6+/-0.2 days, respectively. Sporadic incidence of epithelial cells in ovariectomized animals occurred at longer intervals (8.6+/-3.8 days). Females with xenografted elephant ovarian tissue demonstrated epithelial cells in vaginal smears at intervals of 4.5+/-1.0 days, for 2.5+/-0.5 days duration, which was significantly longer than the other groups (P < 0.05). Histological evaluation of tissues at the time of epithelial cells in smears demonstrated well-developed antral follicles, although oocytes were of poor morphological appearance or only cumulus-like complexes were seen. The nude mouse model is effective for assessing cryopreserved ovarian tissue xenograft function which can support the development of antral follicles.

  2. "African Connection."

    ERIC Educational Resources Information Center

    Adelman, Cathy; And Others

    This interdisciplinary unit provides students in grades kindergarten through seventh grade an opportunity to understand diversity through a study of Africa as a diverse continent. The project is designed to provide all elementary students with cultural enrichment by exposing them to African music, art, storytelling, and movement. This project can…

  3. Preliminary studies developing methods for the control of Chrysomya putoria, the African latrine fly, in pit latrines in The Gambia

    PubMed Central

    Lindsay, T C; Jawara, M; D'Alessandro, U; Pinder, M; Lindsay, S W

    2013-01-01

    Objective To explore ways of controlling Chrysomya putoria, the African latrine fly, in pit latrines. As pit latrines are a major source of these flies, eliminating these important breeding sites is likely to reduce village fly populations, and may reduce the spread of diarrhoeal pathogens. Methods We treated 24 latrines in a Gambian village: six each with (i) pyriproxyfen, an insect juvenile hormone mimic formulated as Sumilarv® 0.5G, a 0.5% pyriproxyfen granule, (ii) expanded polystyrene beads (EPB), (iii) local soap or (iv) no treatment as controls. Flies were collected using exit traps placed over the drop holes, weekly for five weeks. In a separate study, we tested whether latrines also function as efficient flytraps using the faecal odours as attractants. We constructed six pit latrines each with a built-in flytrap and tested their catching efficiency compared to six fish-baited box traps positioned 10 m from the latrine. Focus group discussions conducted afterwards assessed the acceptability of the flytrap latrines. Results Numbers of emerging C. putoria were reduced by 96.0% (95% CIs: 94.5–97.2%) 4–5 weeks after treatment with pyriproxyfen; by 64.2% (95% CIs: 51.8–73.5%) after treatment with local soap; by 41.3% (95% CIs = 24.0–54.7%) after treatment with EPB 3–5 weeks after treatment. Flytraps placed on latrines collected C. putoria and were deemed acceptable to local communities. Conclusions Sumilarv 0.5G shows promise as a chemical control agent, whilst odour-baited latrine traps may prove a useful method of non-chemical fly control. Both methods warrant further development to reduce fly production from pit latrines. A combination of interventions may prove effective for the control of latrine flies and the diseases they transmit. PMID:23198767

  4. Regional trade and the nutrition transition: opportunities to strengthen NCD prevention policy in the Southern African Development Community

    PubMed Central

    Thow, Anne Marie; Sanders, David; Drury, Eliza; Puoane, Thandi; Chowdhury, Syeda N.; Tsolekile, Lungiswa; Negin, Joel

    2015-01-01

    Background Addressing diet-related non-communicable diseases (NCDs) will require a multisectoral policy approach that includes the food supply and trade, but implementing effective policies has proved challenging. The Southern African Development Community (SADC) has experienced significant trade and economic liberalization over the past decade; at the same time, the nutrition transition has progressed rapidly in the region. This analysis considers the relationship between regional trade liberalization and changes in the food environment associated with poor diets and NCDs, with the aim of identifying feasible and proactive policy responses to support healthy diets. Design Changes in trade and investment policy for the SADC were documented and compared with time-series graphs of import data for soft drinks and snack foods to assess changes in imports and source country in relation to trade and investment liberalization. Our analysis focuses on regional trade flows. Results Diets and the burden of disease in the SADC have changed since the 1990s in parallel with trade and investment liberalization. Imports of soft drinks increased by 76% into SADC countries between 1995 and 2010, and processed snack foods by 83%. South Africa acts as a regional trade and investment hub; it is the major source of imports and investment related to these products into other SADC countries. At the same time, imports of processed foods and soft drinks from outside the region – largely from Asia and the Middle East – are increasing at a dramatic rate with soft drink imports growing by almost 1,200% and processed snack foods by 750%. Conclusions There is significant intra-regional trade in products associated with the nutrition transition; however, growing extra-regional trade means that countries face new pressures in implementing strong policies to prevent the increasing burden of diet-related NCDs. Implementation of a regional nutrition policy framework could complement the SADC

  5. Development of a field-friendly technique for fecal steroid extraction and storage using the African wild dog (Lycaon pictus).

    PubMed

    Santymire, R M; Armstrong, D M

    2010-01-01

    Hormonal analysis provides information about wildlife populations, but is difficult to conduct in the field. Our goal was to develop a rapid and effective field method for fecal steroid analysis by comparing: (1) three extraction methods (laboratory (LAB), homogenize (HO) and handshake (HS)) and (2) two storage methods (solid-phase extraction (SPE) tubes vs. plastic tubes (PT)). Samples (n=23) from captive African wild dogs (Lycaon pictus) were thoroughly mixed, three aliquots of each were weighed ( approximately 0.5 g) and 5 ml of 90% ethanol was added. For LAB, samples were agitated (mixer setting 60; 30 min), centrifuged (1,500 rpm; 20 min) and poured into glass tubes. Or aliquots were HO (1 min) or HS (1 min) and poured through filter paper into glass tubes. Samples were split, analyzed for corticosterone (C) and testosterone (T) metabolites using enzyme immunoassays or stored in SPE or PT. Samples were stored (room temperature) for 30, 60 or 180 days, reconstituted in buffer and analyzed. Mean C and T recoveries of HO were greater (P=0.03) than HS compared with LAB, which was similar to HO (P>0.05). After 30 days <21% of C and T was recovered from SPE, but approximately 100% of each was recovered from HO-PT and HS-PT. Similarly, after 60 and 180 days, approximately 100% of C and T was recovered from HO-PT and HS-PT. Results demonstrated that, for C and T, HO was more comparable (P<0.001) to LAB than HS and PT storage was more efficient than SPE (P<0.001).

  6. Development and Use of a Serum Bactericidal Assay Using Pooled Human Complement To Assess Responses to a Meningococcal Group A Conjugate Vaccine in African Toddlers

    PubMed Central

    Lynn, Freyja; Mocca, Brian; Borrow, Ray; Findlow, Helen; Hassan-King, Musa; Preziosi, Marie-Pierre; Idoko, Olubukola; Sow, Samba; Kulkarni, Prasad; LaForce, F. Marc

    2014-01-01

    A meningococcal group A polysaccharide (PS) conjugate vaccine (PsA-TT) has been developed for African countries affected by epidemic meningitis caused by Neisseria meningitidis. Complement-mediated serum bactericidal antibody (SBA) assays are used to assess protective immune responses to meningococcal vaccination. Human complement (hC′) was used in early studies demonstrating antibody-mediated protection against disease, but it is difficult to obtain and standardize. We developed and evaluated a method for sourcing hC′ and then used the SBA assay with hC′ (hSBA) to measure bactericidal responses to PsA-TT vaccination in 12- to 23-month-old African children. Sera with active complement from 100 unvaccinated blood donors were tested for intrinsic bactericidal activity, SBA titer using rabbit complement (rSBA), and anti-group A PS antibody concentration. Performance criteria and pooling strategies were examined and then verified by comparisons of three independently prepared hC′ lots in two laboratories. hSBA titers of clinical trial sera were then determined using this complement sourcing method. Two different functional antibody tests were necessary for screening hC′. hSBA titers determined using three independent lots of pooled hC′ were within expected assay variation among lots and between laboratories. In African toddlers, PsA-TT elicited higher hSBA titers than meningococcal polysaccharide or Hib vaccines. PsA-TT immunization or PS challenge of PsA-TT-primed subjects resulted in vigorous hSBA memory responses, and titers persisted in boosted groups for over a year. Quantifying SBA using pooled hC′ is feasible and showed that PsA-TT was highly immunogenic in African toddlers. PMID:24671551

  7. African early childhood development curriculum and pedagogy for Turkana nomadic pastoralist communities of Kenya.

    PubMed

    Ng'asike, John T

    2014-01-01

    Western conceptions of child development and the models of early education they engender predominantly shape services for young children in the first eight years of life all over Africa. This chapter brings a reconceptualist perspective to the critique of Kenya's continuing failure to ground early childhood programs and services in local cultural conceptions, developmental values, childrearing practices, and the practical day-to-day realities of children's learning through participation and apprenticeship in the contexts of family routines, community experiences, and economic survival activities. The chapter draws on work I have conducted in nomadic pastoralist communities in Kenya. That research reveals the disconcerting reality that (a) early childhood education programs privilege Western pedagogical practices over equally effective and locally more relevant ones, and (b) local communities are increasingly resentful of an educational system that alienates their children from their cultural roots in the name of modernization. Asserting the educational value of indigenous knowledge, I present a framework for integrating that knowledge and the naturalistic learning processes in local contexts into instructional programs in formal ECE settings. PMID:25512045

  8. Does atrazine affect larval development and sexual differentiation of South African clawed frogs?

    PubMed

    Kloas, Werner; Lutz, Ilka; Urbatzka, Ralph; Springer, Tim; Krueger, Hank; Wolf, Jeffrey; Holden, Larry; Hosmer, Alan

    2009-04-01

    The potential impact of atrazine (ATZ) on gonadal malformations in larval Xenopus laevis has been controversially discussed, and a hypothesis has been generated that ATZ might induce the estrogen-synthesizing enzyme aromatase, leading to feminization or demasculinization. Recently, extensive long-term studies clearly indicate that no adverse effect of ATZ on larval development and sexual differentiation could be found. Therefore, to determine potential transient impacts of ATZ on sexual differentiation processes, short-term exposures were conducted using tadpoles treated for 4 days with ATZ at 25 microg/L. The expression levels of the key players for sexual differentiation in amphibians were determined in the brain, assessing aromatase, 5alpha-reductase type 1 (S1) and type 2 (S2), and the gonadotropins luteinizing hormone and follicle-stimulating hormone, and in the gonads, measuring aromatase, S1, and S2, by means of quantitative RT-PCR. No significant changes in any of these parameters have been found, implicating, in accordance with recent long-term exposures, that no aromatase induction by ATZ could be observed, and it seems likely that no further endocrine mechanism of ATZ affecting sexual differentiation in X. laevis exists.

  9. Altered cerebellum development and impaired motor coordination in mice lacking the Btg1 gene: Involvement of cyclin D1.

    PubMed

    Ceccarelli, Manuela; Micheli, Laura; D'Andrea, Giorgio; De Bardi, Marco; Scheijen, Blanca; Ciotti, MariaTeresa; Leonardi, Luca; Luvisetto, Siro; Tirone, Felice

    2015-12-01

    Cerebellar granule neurons develop postnatally from cerebellar granule precursors (GCPs), which are located in the external granule layer (EGL) where they massively proliferate. Thereafter, GCPs become postmitotic, migrate inward to form the internal granule layer (IGL), further differentiate and form synapses with Purkinje cell dendrites. We previously showed that the Btg family gene, Tis21/Btg2, is required for normal GCP migration. Here we investigated the role in cerebellar development of the related gene, Btg1, which regulates stem cell quiescence in adult neurogenic niches, and is expressed in the cerebellum. Knockout of Btg1 in mice caused a major increase of the proliferation of the GCPs in the EGL, whose thickness increased, remaining hyperplastic even after postnatal day 14, when the EGL is normally reduced to a few GCP layers. This was accompanied by a slight decrease of differentiation and migration of the GCPs and increase of apoptosis. The GCPs of double Btg1/Tis21-null mice presented combined major defects of proliferation and migration outside the EGL, indicating that each gene plays unique and crucial roles in cerebellar development. Remarkably, these developmental defects lead to a permanent increase of the adult cerebellar volume in Btg1-null and double mutant mice, and to impairment in all mutants, including Tis21-null, of the cerebellum-dependent motor coordination. Gain- and loss-of-function strategies in a GCP cell line revealed that Btg1 regulates the proliferation of GCPs selectively through cyclin D1. Thus, Btg1 plays a critical role for cerebellar maturation and function.

  10. Emergence of Rich-Club Topology and Coordinated Dynamics in Development of Hippocampal Functional Networks In Vitro

    PubMed Central

    Charlesworth, Paul; Kitzbichler, Manfred G.; Paulsen, Ole

    2015-01-01

    Recent studies demonstrated that the anatomical network of the human brain shows a “rich-club” organization. This complex topological feature implies that highly connected regions, hubs of the large-scale brain network, are more densely interconnected with each other than expected by chance. Rich-club nodes were traversed by a majority of short paths between peripheral regions, underlining their potential importance for efficient global exchange of information between functionally specialized areas of the brain. Network hubs have also been described at the microscale of brain connectivity (so-called “hub neurons”). Their role in shaping synchronous dynamics and forming microcircuit wiring during development, however, is not yet fully understood. The present study aimed to investigate the role of hubs during network development, using multi-electrode arrays and functional connectivity analysis during spontaneous multi-unit activity (MUA) of dissociated primary mouse hippocampal neurons. Over the first 4 weeks in vitro, functional connectivity significantly increased in strength, density, and size, with mature networks demonstrating a robust modular and small-world topology. As expected by a “rich-get-richer” growth rule of network evolution, MUA graphs were found to form rich-clubs at an early stage in development (14 DIV). Later on, rich-club nodes were a consistent topological feature of MUA graphs, demonstrating high nodal strength, efficiency, and centrality. Rich-club nodes were also found to be crucial for MUA dynamics. They often served as broker of spontaneous activity flow, confirming that hub nodes and rich-clubs may play an important role in coordinating functional dynamics at the microcircuit level. PMID:25855164

  11. The Birth of a South African Child Development Center for 2- to 6-Year-Olds: An International Partnership

    ERIC Educational Resources Information Center

    DeMarie, Darlene; Cherian, Lily

    2012-01-01

    Providing high-quality education and care for young children at a historically Black university in rural South Africa was a challenging task. But despite many obstacles, two teacher educators (an American and a South African) worked together, partnered with a surprising collection of others, seized every possible opportunity, and persisted, seeing…

  12. Ethics, Power, and Privilege: Salient Issues in the Development of Multicultural Competencies for Teachers Serving African American Children with Disabilities.

    ERIC Educational Resources Information Center

    Day-Vines, Norma L.

    2000-01-01

    This article addresses educators' ethical responsibility for recognizing the inherent dignity and worth of African American students with disabilities. It opens with a brief overview of multicultural education and continues with a three-pronged model for addressing multicultural competencies: awareness, knowledge, and skills. Strategies for…

  13. Nutrition and Physical Activity Knowledge Assessment: Development of Questionnaires and Evaluation of Reliability in African American and Latino Children

    ERIC Educational Resources Information Center

    Roberts, Lindsay S.; Sharma, Sushma; Hudes, Mark L.; Fleming, Sharon E.

    2012-01-01

    Background: African-American and Latino children living in neighborhoods with a low-socioeconomic index are more at risk of obesity-associated metabolic disease than their higher socioeconomic index and/or white peers. Currently, consistent and reliable questionnaires to evaluate nutrition and physical activity knowledge in these children are…

  14. The Role of Literary Mentors in Writing Development: How African American Women's Literature Supported the Writings of Adolescent Girls

    ERIC Educational Resources Information Center

    Muhammad, Gholnecsar E.

    2015-01-01

    Coupling Royster's (2000) conceptual framework of "zamani" with Rosenblatt's (1978) reader response theory, the researcher explores the ways African American women's writings supported, nurtured, and "mentored" the writings of adolescent girls. Findings show that the mentor texts helped in generating ideas for writing, thinking…

  15. Effects of Robust Vocabulary Instruction and Multicultural Text on the Development of Word Knowledge among African American Children

    ERIC Educational Resources Information Center

    Lovelace, Sherri; Stewart, Sharon R.

    2009-01-01

    Purpose: To examine the effect of a systematic vocabulary instructional technique in African American 2nd-grade children with below average vocabulary skills. An additional goal was to examine the role of book type in the retention of novel vocabulary words. Method: Using an adapted alternating treatments design, storybooks were used as a source…

  16. African-American English and Reading Achievement: The Relationships among Dialect Awareness, Dialect Shifting and Reading Development

    ERIC Educational Resources Information Center

    Sajous-Brady, Daphne Lucienne

    2012-01-01

    When children begin to connect spoken speech to print, regardless of their language, they all encounter disparities between oral and written representations. Children who speak the African-American English (AAE) dialect at home and in their communities may encounter an even greater number of disparities between oral and written representations…

  17. New Branches from Old Roots: Experts Respond to Questions about African American English Development and Language Intervention

    ERIC Educational Resources Information Center

    Burns, Frances A.; Velleman, Shelley L.; Green, Lisa J.; Roeper, Tom

    2010-01-01

    This article uses a question-and-answer format to respond to questions about working with children who speak African American English (AAE) in clinical and educational contexts. The respondents urge speech-language pathologists to appreciate AAE as students' first language, to view all language for its communicative potential, and to remain aware…

  18. Developing Culturally Responsive Surveys: Lessons in Development, Implementation, and Analysis from Brazil's African Descent Communities

    ERIC Educational Resources Information Center

    Bowen, Merle L.; Tillman, Ayesha S.

    2015-01-01

    Considerable empirical research, along with a growing body of conceptual and theoretical literature, exists on the role of culture and context in evaluation. Less scholarship has examined culturally responsive surveys in the context of international evaluation. In this article, the authors present lessons learned from the development,…

  19. Elevated and sustained desire for sweet taste in african-americans: a potential factor in the development of obesity.

    PubMed

    Schiffman, S S; Graham, B G; Sattely-Miller, E A; Peterson-Dancy, M

    2000-10-01

    Oral habituation is a relatively long-lasting decrease in oral responsiveness that results from the repeated presentation of a single stimulus. The purpose of this study was to evaluate the degree of habituation to sweet-tasting foods and to determine whether there are differences in the rate of habituation between African Americans and European Americans. These two groups were compared because the prevalence of obesity and obesity-related disorders such as diabetes and hypertension is significantly higher among African Americans than among European Americans. Nine different commercial foods and beverages that differed in sweetness intensity and caloric density served as stimuli. Subjects tasted and rated each food once per minute for a 30-min period on scales related to desire for another taste of the same sample and desire for a different taste. The stimuli and portion size for each of the 30 samples were two candy bars (Ultra Slim-Fast Cocoa Almond Crunch Bar, 1/16 of a bar; Natural Nectar Peanut Butter Granola Bar, 1/16 of a bar), three beverages (Nestea Lemon Flavored Instant Tea with NutraSweet, 5 mL; Welch's Grape Juice, 5 mL; Pink Swimmingo Kool-Aid, 5 mL), two gelatin desserts (Cherry Flavored Jell-O Gelatin, 5 g; Cherry Flavored Jell-O Gelatin with NutraSweet, 5 g), one enteral nutrition drink (Vanilla Ensure Plus, 5 mL), and one pudding (Ultra Slim-Fast Chocolate Pudding, 5 g). Subjects consumed the entire portion of each sample. Habituation occurred for seven of the nine foods as judged by a decrease in the desire for another taste of the same food. The degree of habituation for European Americans and African Americans was similar except for the sweetest food (Cherry Flavored Jell-O Gelatin with NutraSweet), for which African Americans showed no habituation. The degree of habituation in both groups was unrelated to caloric density. Overall, young African Americans had a significantly greater desire for another taste of the same food than did young

  20. SiHLEWeb.com: Development and Usability Testing of an Evidence-Based HIV/STI Prevention Website for Female African-American Adolescents

    PubMed Central

    Danielson, Carla Kmett; McCauley, Jenna L.; Gros, Kirstin Stauffacher; Jones, Andrea M.; Barr, Simone C.; Borkman, April L.; Bryant, Brittany G.; Ruggiero, Kenneth J.

    2014-01-01

    African-American adolescent girls are at disproportionate risk for HIV infection. Although numerous evidence-based risk-reduction interventions exist, dissemination and implementation resources remain limited, and prevention services remain notably inaccessible to the very populations at highest risk for HIV infection. Internet delivery of HIV risk-reduction programming has promise as a mechanism for extending the reach of existing prevention efforts and overcoming barriers associated with traditional service delivery. This article: (1) details the development process for the creation of SiHLEWeb, a web-adapted version of an evidence-based, culturally-informed HIV prevention program traditionally delivered to female African-American adolescents via an in-person group format; and (2) presents findings from quantitative and qualitative usability testing conducted among 18 African-American girls (13–18). Results suggest that users found the website improved knowledge and learning, was helpful, efficient to use, and generally attractive. Users reported some concerns about website navigation. Implications for internet delivery of health prevention programming are discussed. PMID:25167865

  1. SiHLEWeb.com: Development and usability testing of an evidence-based HIV prevention website for female African-American adolescents.

    PubMed

    Danielson, Carla Kmett; McCauley, Jenna L; Gros, Kirstin Stauffacher; Jones, Andrea M; Barr, Simone C; Borkman, April L; Bryant, Brittany G; Ruggiero, Kenneth J

    2016-06-01

    African-American adolescent girls are at disproportionate risk for HIV infection. Although numerous evidence-based risk-reduction interventions exist, dissemination and implementation resources remain limited, and prevention services remain notably inaccessible to the very populations at highest risk for HIV infection. Internet delivery of HIV risk-reduction programming has promise as a mechanism for extending the reach of existing prevention efforts and overcoming barriers associated with traditional service delivery. This article (1) details the development process for the creation of SiHLEWeb, a web-adapted version of an evidence-based, culturally informed HIV prevention program traditionally delivered to female African-American adolescents via an in-person group format, and (2) presents findings from quantitative and qualitative usability testing conducted among 18 African-American girls (13-18 years). Results suggest that users found the website improved knowledge and learning, was helpful, efficient to use, and generally attractive. Users reported some concerns about website navigation. Implications for Internet delivery of health prevention programming are discussed.

  2. Applying Metaphors for Learning to Continuing Professional Development (CPD), in the Context of a Course for Special Educational Needs Coordinators (SENCOs)

    ERIC Educational Resources Information Center

    Pearson, Sue; Scott, Phil; Sugden, David

    2011-01-01

    The literature suggests that understandings of teaching and learning can be classified around two metaphors: acquisition and participation. It is further argued that neither metaphor is sufficient and that both are necessary. Drawing on material from a larger study related to the professional development of Special Educational Needs Coordinators,…

  3. Coordinated Collection Development via CD-ROM. A Pilot Project Granted by LSCA Title III Funds to Crosby Library, Gonzaga University. Final Narrative Report.

    ERIC Educational Resources Information Center

    Peterson, Elaine; Carr, Mary M.

    Three colleges in the state of Washington--Gonzaga College (Crosby Library), Whitworth College, and Eastern Washington University--received grants from the Fred Meyer Charitable Trust and the Library Services and Construction Act to facilitate coordinated collection development in the areas of education and business/economics, so that their…

  4. Assessment of the Communicative and Coordination Skills of Children with Autism Spectrum Disorders and Typically Developing Children Using Social Signal Processing

    ERIC Educational Resources Information Center

    Delaherche, Emilie; Chetouani, Mohamed; Bigouret, Fabienne; Xavier, Jean; Plaza, Monique; Cohen, David

    2013-01-01

    To cooperate with a partner, it is essential to communicate by sharing information through all available avenues, including hand gestures, gazes, head gestures and naturally, speech. In this paper, we compare the communicative and coordination skills of children with typical development to those of children with Autism Spectrum Disorders (ASDs) in…

  5. COORDINATED AV.

    ERIC Educational Resources Information Center

    CLEAVES, PAUL C.; AND OTHERS

    THE INSTRUCTIONAL MATERIALS CENTER IS LOCATED IN THE LOCAL HIGH SCHOOL AND SUPPLIES ALL SCHOOLS IN THE AREA. AUDIOVISUAL EQUIPMENT ORDERS, AFTER SELECTIONS ARE MADE BY THE CLASSROOM TEACHER, ARE PROCESSED BY THE CENTER, CONFIRMED AND DELIVERED BY TRUCK THREE TIMES EACH WEEK. EACH SCHOOL HAS A BUILDING COORDINATOR WHO CHECKS THE ORDERS INTO THE…

  6. Evaluation of potential variables contributing to the development and duration of plantar lesions in a population of aquarium-maintained African penguins (Spheniscus demersus).

    PubMed

    Erlacher-Reid, Claire; Dunn, J Lawrence; Camp, Tracy; Macha, Laurie; Mazzaro, Lisa; Tuttle, Allison D

    2012-01-01

    Bumblefoot (pododermatitis), often described as the most significant environmental disease of captive penguins, is commonly due to excessive pressure or trauma on the plantar surface of the avian foot, resulting in inflammation or necrosis and causing severe swelling, abrasions, or cracks in the skin. Although not formally evaluated in penguins, contributing factors for bumblefoot are thought to be similar to those initiating the condition in raptors and poultry. These factors include substrate, body weight, and lack of exercise. The primary purpose of this retrospective study was to evaluate variables potentially contributing to the development and duration of plantar lesions in aquarium-maintained African penguins (Spheniscus demersus), including sex, weight, age, season, exhibit activity, and territory substrate. Results indicate that males develop significantly more plantar lesions than females. Penguins weighing between 3.51 and 4.0 kg develop plantar lesions significantly more often than penguins weighing between 2.5 and 3.5 kg, and because male African penguins ordinarily weigh significantly more than females, weight is likely a contributing factor in the development of lesions in males compared with females. Significantly more plantar lesions were observed in penguins standing for greater than 50% of their time on exhibit than swimming. Penguins occupying smooth concrete territories developed more plantar lesions compared with penguins occupying grate territories. Recommendations for minimizing bumblefoot in African penguins include training penguins for monthly foot examinations for early detection of plantar lesions predisposing for the disease, encouraging swimming activity, and replacing smooth surfaces on exhibit with surfaces providing variable degrees of pressure and texture on the feet. PMID:21557300

  7. Evaluation of potential variables contributing to the development and duration of plantar lesions in a population of aquarium-maintained African penguins (Spheniscus demersus).

    PubMed

    Erlacher-Reid, Claire; Dunn, J Lawrence; Camp, Tracy; Macha, Laurie; Mazzaro, Lisa; Tuttle, Allison D

    2012-01-01

    Bumblefoot (pododermatitis), often described as the most significant environmental disease of captive penguins, is commonly due to excessive pressure or trauma on the plantar surface of the avian foot, resulting in inflammation or necrosis and causing severe swelling, abrasions, or cracks in the skin. Although not formally evaluated in penguins, contributing factors for bumblefoot are thought to be similar to those initiating the condition in raptors and poultry. These factors include substrate, body weight, and lack of exercise. The primary purpose of this retrospective study was to evaluate variables potentially contributing to the development and duration of plantar lesions in aquarium-maintained African penguins (Spheniscus demersus), including sex, weight, age, season, exhibit activity, and territory substrate. Results indicate that males develop significantly more plantar lesions than females. Penguins weighing between 3.51 and 4.0 kg develop plantar lesions significantly more often than penguins weighing between 2.5 and 3.5 kg, and because male African penguins ordinarily weigh significantly more than females, weight is likely a contributing factor in the development of lesions in males compared with females. Significantly more plantar lesions were observed in penguins standing for greater than 50% of their time on exhibit than swimming. Penguins occupying smooth concrete territories developed more plantar lesions compared with penguins occupying grate territories. Recommendations for minimizing bumblefoot in African penguins include training penguins for monthly foot examinations for early detection of plantar lesions predisposing for the disease, encouraging swimming activity, and replacing smooth surfaces on exhibit with surfaces providing variable degrees of pressure and texture on the feet.

  8. The Design and Evaluation of African Language Learning Materials. Proceedings of the Spring 1984 Conference on Developing Guidelines for the Evaluation of African Language Learning Materials (East Lansing, Michigan, April 13-14, 1984).

    ERIC Educational Resources Information Center

    Dwyer, David J., Ed.

    Representatives from major institutions teaching African languages convened to discuss the design of African language textbooks and to propose guidelines for the writing of new textbooks and evaluation of existing ones. Conference papers include: "Language Acquisition Theory and Materials Construction" (Stephen Krashen); "The Structures of Verbal…

  9. Obesity and African Americans

    MedlinePlus

    ... Data > Minority Population Profiles > Black/African American > Obesity Obesity and African Americans African American women have the ... ss6304.pdf [PDF | 3.38MB] HEALTH IMPACT OF OBESITY More than 80 percent of people with type ...

  10. African American Advanced Placement chemistry students and their developing study habits: A phenomenologically-based interpretive study

    NASA Astrophysics Data System (ADS)

    Rasmussen, Natalie D.

    The academic achievement gap between African American and White students has gained much attention in recent years. Much has been written about the causes of and reasons for this problem ranging from the vestigial effects of slavery to poor parenting. Much less has been written or understood about its solution. While it is impossible for educators to change the pasts of their African American students, it is possible to effect change for the few minutes in which they are in direct contact with them each day. If African American science students are taught effective study skills and habits, then perhaps they might have the tools to close the achievement gap themselves. The participants in this phenomenologically based interpretive study were five African American Advanced Placement Chemistry students from an inner-city high school. Three in-depth interviews were conducted with each of the participants during the beginning, middle and end of a semester. The purpose of the interviews was to locate the students in terms of their thought processes, experiences and perceived barriers concerning the nature and practice of effective study and retention of chemistry content. The interviews were recorded and transcribed. The texts were then analyzed for common themes. Five common themes emerged from the interviews. These were: (1) Homework vs. Study: a distinction between homework---which students knew how to approach; and study---which they did not. (2) Student Effort: their changing perception of adequate and effective study practices while in a rigorous course. (3) Teacher Rigor: they perceived high expectations and challenging work as a sign of respect from their teachers. (4) Parental Involvement: students' admission that they desired more input from parents regarding their academic performance. (5) Racial Considerations: their need to disprove negative stereotypes and their personal observations regarding racial differences in studying. A discussion of the themes and

  11. Physical Education for Poorly Co-ordinated Children. The Promotion of Body Awareness and the Development of Basic Skills.

    ERIC Educational Resources Information Center

    Watson, Bevilie R.

    This book deals with the promotion of body awareness through use of educational gymnastics, with handicapped or non-handicapped but poorly coordinated children of all age levels. The method provides an analytical approach to movement, encourages children to listen to language, and assists them in creating their own activities. The activities and…

  12. Gesture Production in School vs. Clinical Samples of Children with Developmental Coordination Disorder (DCD) and Typically Developing Children

    ERIC Educational Resources Information Center

    Sinani, Charikleia; Sugden, David A.; Hill, Elisabeth L.

    2011-01-01

    Dyspraxia, a difficulty in executing an operationalised act, has been associated with Developmental Coordination Disorder (DCD). However, issues relating to the area such as comparisons across modalities, comparisons of school vs. clinical populations, and developmental delay vs. pathology have not been addressed in the same, comprehensive study.…

  13. Images of Male Friendships: An Investigation of How African American Undergraduate Men Develop Interpersonal Relationships with Other Men at a Predominantly White Institution

    ERIC Educational Resources Information Center

    McGowan, Brian Lamont

    2013-01-01

    African American men enter postsecondary institutions having been socialized to adopt stereotypical notions of masculinity. These traditional expectations of masculinity play a role in how African American men negotiate relationships with their male counterparts on the campus. African American men cultivate close relationships with other men to…

  14. DEVELOPING AND EXPLOITING A UNIQUE SEISMIC DATA SET FROM SOUTH AFRICAN GOLD MINES FOR SOURCE CHARACTERIZATION AND WAVE PROPAGATION

    SciTech Connect

    Julia, J; Nyblade, A A; Gok, R; Walter, W R; Linzer, L; Durrheim, R

    2008-07-08

    In this project, we are developing and exploiting a unique seismic data set to address the characteristics of small seismic events and the associated seismic signals observed at local (< 200 km) and regional (< 2000 km) distances. The dataset is being developed using mining-induced events from 3 deep gold mines in South Africa recorded on inmine networks (< 1 km) comprised of tens of high-frequency sensors, a network of 4 broadband stations installed as part of this project at the surface around the mines (1-10 km), and a network of existing broadband seismic stations at local/regional distances (50-1000 km) from the mines. After 1 year of seismic monitoring of mine activity (2007), over 10,000 events in the range -3.4 < ML < 4.4 have been catalogued and recorded by the in-mine networks. Events with positive magnitudes are generally well recorded by the surface-mine stations, while magnitudes 3.0 and larger are seen at regional distances (up to {approx}600 km) in high-pass filtered recordings. We have analyzed in-mine recordings in detail at one of the South African mines (Savuka) to (i) improve on reported hypocentral locations, (ii) verify sensor orientations, and (iii) determine full moment tensor solutions. Hypocentral relocations on all catalogued events have been obtained from P- and S-wave travel-times reported by the mine network operator through an automated procedure that selects travel-times falling on Wadati lines with slopes in the 0.6-0.7 range; sensor orientations have been verified and, when possible, corrected by correlating P-, SV-, and SH-waveforms obtained from theoretical and empirical (polarization filter) rotation angles; full moment tensor solutions have been obtained by inverting P-, SV-, and SH- spectral amplitudes measured on the theoretically rotated waveforms with visually assigned polarities. The relocation procedure has revealed that origin times often necessitate a negative correction of a few tenths of second and that hypocentral

  15. International Assistance for Low-Emission Development Planning: Coordinated Low Emissions Assistance Network (CLEAN) Inventory of Activities and Tools--Preliminary Trends

    SciTech Connect

    Cox, S.; Benioff, R.

    2011-05-01

    The Coordinated Low Emissions Assistance Network (CLEAN) is a voluntary network of international practitioners supporting low-emission planning in developing countries. The network seeks to improve quality of support through sharing project information, tools, best practices and lessons, and by fostering harmonized assistance. CLEAN has developed an inventory to track and analyze international technical support and tools for low-carbon planning activities in developing countries. This paper presents a preliminary analysis of the inventory to help identify trends in assistance activities and tools available to support developing countries with low-emission planning.

  16. Race, health, and the African Diaspora.

    PubMed

    Spigner, Clarence

    Health inequalities exist throughout the African Diaspora and are viewed in this article as largely color-coded. In developed, developing, and undeveloped nations today, "racial" stratification is consistently reflected in an inability to provide adequate health regardless of national policy or ideology. For instance, African Americans experience less than adequate health care very similar to Blacks in Britain, in spite of each nations differing health systems. Latin America's Africana Negra communities experience poorer health similar to Blacks throughout the Caribbean. The African continent itself is arguably the poorest on earth. A common history of racism correlates with health disparities across the African Diaspora.

  17. Genome-Wide Association Study to Identify Single Nucleotide Polymorphisms (SNPs) Associated With the Development of Erectile Dysfunction in African-American Men After Radiotherapy for Prostate Cancer

    SciTech Connect

    Kerns, Sarah L.; Ostrer, Harry; Stock, Richard; Li, William; Pearlman, Alexander; Campbell, Christopher; Shao Yongzhao; Stone, Nelson; Kusnetz, Lynda; Rosenstein, Barry S.

    2010-12-01

    Purpose: To identify single nucleotide polymorphisms (SNPs) associated with erectile dysfunction (ED) among African-American prostate cancer patients treated with external beam radiation therapy. Methods and Materials: A cohort of African-American prostate cancer patients treated with external beam radiation therapy was observed for the development of ED by use of the five-item Sexual Health Inventory for Men (SHIM) questionnaire. Final analysis included 27 cases (post-treatment SHIM score {<=}7) and 52 control subjects (post-treatment SHIM score {>=}16). A genome-wide association study was performed using approximately 909,000 SNPs genotyped on Affymetrix 6.0 arrays (Affymetrix, Santa Clara, CA). Results: We identified SNP rs2268363, located in the follicle-stimulating hormone receptor (FSHR) gene, as significantly associated with ED after correcting for multiple comparisons (unadjusted p = 5.46 x 10{sup -8}, Bonferroni p = 0.028). We identified four additional SNPs that tended toward a significant association with an unadjusted p value < 10{sup -6}. Inference of population substructure showed that cases had a higher proportion of African ancestry than control subjects (77% vs. 60%, p = 0.005). A multivariate logistic regression model that incorporated estimated ancestry and four of the top-ranked SNPs was a more accurate classifier of ED than a model that included only clinical variables. Conclusions: To our knowledge, this is the first genome-wide association study to identify SNPs associated with adverse effects resulting from radiotherapy. It is important to note that the SNP that proved to be significantly associated with ED is located within a gene whose encoded product plays a role in male gonad development and function. Another key finding of this project is that the four SNPs most strongly associated with ED were specific to persons of African ancestry and would therefore not have been identified had a cohort of European ancestry been screened. This study

  18. Charting the pipeline: Identifying the critical elements in the development of successful African American scientists, engineers, and mathematicians

    NASA Astrophysics Data System (ADS)

    Williams, Brian Anthony

    Many educational researchers are concerned with the apparent poor performance of different racial and ethnic groups in the fields of science, engineering, and mathematics in the United States. Despite improvements in the performance of African Americans, Hispanic Americans, and Native Americans in these areas over the past decade, these groups are still less likely to enroll in advanced math and science courses or score at or above the proficient level in mathematics. Furthermore, these groups continue to be underrepresented in the nation's technical and scientific workforce. The purpose of this study was to identify the critical elements related to the success of African Americans in science, engineering, and mathematics. Specifically, this study was designed to answer the following questions as they pertained to African American graduate students: What factors were perceived to have contributed to the students' initial interest in science, engineering, or mathematics? What factors were perceived to have contributed to the students' decisions to continue their studies in their specific areas of interest? What factors, associated with the K--12 schooling experience, were perceived to have contributed to the students' success in science, engineering, or mathematics? The data for the study were acquired from interviews with 32 African American students (16 males and 16 females) who were engaged in graduate work in science, engineering, or mathematics. Four major themes emerged from the analysis of the interview data. The first was that all students were involved in experiences that allowed a significant level of participation in science, engineering, and mathematics. Second, all of the students experienced some form of positive personal intervention by another person. Third, all students possessed perceptions of these fields that involved some sort of positive outcome. Finally, all of the of the students believed they possessed intrinsic qualities that qualified and

  19. Zn(II)-coordination modulated ligand photophysical processes – the development of fluorescent indicators for imaging biological Zn(II) ions

    PubMed Central

    Yuan, Zhao; Simmons, J. Tyler; Sreenath, Kesavapillai

    2014-01-01

    Molecular photophysics and metal coordination chemistry are the two fundamental pillars that support the development of fluorescent cation indicators. In this article, we describe how Zn(II)-coordination alters various ligand-centered photophysical processes that are pertinent to developing Zn(II) indicators. The main aim is to show how small organic Zn(II) indicators work under the constraints of specific requirements, including Zn(II) detection range, photophysical requirements such as excitation energy and emission color, temporal and spatial resolutions in a heterogeneous intracellular environment, and fluorescence response selectivity between similar cations such as Zn(II) and Cd(II). In the last section, the biological questions that fluorescent Zn(II) indicators help to answer are described, which have been motivating and challenging this field of research. PMID:25071933

  20. Developing a computer touch-screen interactive colorectal screening decision aid for a low-literacy African American population: lessons learned.

    PubMed

    Bass, Sarah Bauerle; Gordon, Thomas F; Ruzek, Sheryl Burt; Wolak, Caitlin; Ruggieri, Dominique; Mora, Gabriella; Rovito, Michael J; Britto, Johnson; Parameswaran, Lalitha; Abedin, Zainab; Ward, Stephanie; Paranjape, Anuradha; Lin, Karen; Meyer, Brian; Pitts, Khaliah

    2013-07-01

    African Americans have higher colorectal cancer (CRC) mortality than White Americans and yet have lower rates of CRC screening. Increased screening aids in early detection and higher survival rates. Coupled with low literacy rates, the burden of CRC morbidity and mortality is exacerbated in this population, making it important to develop culturally and literacy appropriate aids to help low-literacy African Americans make informed decisions about CRC screening. This article outlines the development of a low-literacy computer touch-screen colonoscopy decision aid using an innovative marketing method called perceptual mapping and message vector modeling. This method was used to mathematically model key messages for the decision aid, which were then used to modify an existing CRC screening tutorial with different messages. The final tutorial was delivered through computer touch-screen technology to increase access and ease of use for participants. Testing showed users were not only more comfortable with the touch-screen technology but were also significantly more willing to have a colonoscopy compared with a "usual care group." Results confirm the importance of including participants in planning and that the use of these innovative mapping and message design methods can lead to significant CRC screening attitude change.