Science.gov

Sample records for age hazard ratio

  1. Inferences about ungulate population dynamics derived from age ratios

    USGS Publications Warehouse

    Harris, N.C.; Kauffman, M.J.; Mills, L.S.

    2008-01-01

    Age ratios (e.g., calf:cow for elk and fawn:doe for deer) are used regularly to monitor ungulate populations. However, it remains unclear what inferences are appropriate from this index because multiple vital rate changes can influence the observed ratio. We used modeling based on elk (Cervus elaphus) life-history to evaluate both how age ratios are influenced by stage-specific fecundity and survival and how well age ratios track population dynamics. Although all vital rates have the potential to influence calf:adult female ratios (i.e., calf:xow ratios), calf survival explained the vast majority of variation in calf:adult female ratios due to its temporal variation compared to other vital rates. Calf:adult female ratios were positively correlated with population growth rate (??) and often successfully indicated population trajectories. However, calf:adult female ratios performed poorly at detecting imposed declines in calf survival, suggesting that only the most severe declines would be rapidly detected. Our analyses clarify that managers can use accurate, unbiased age ratios to monitor arguably the most important components contributing to sustainable ungulate populations, survival rate of young and ??. However, age ratios are not useful for detecting gradual declines in survival of young or making inferences about fecundity or adult survival in ungulate populations. Therefore, age ratios coupled with independent estimates of population growth or population size are necessary to monitor ungulate population demography and dynamics closely through time.

  2. Moving beyond the hazard ratio in quantifying the between-group difference in survival analysis.

    PubMed

    Uno, Hajime; Claggett, Brian; Tian, Lu; Inoue, Eisuke; Gallo, Paul; Miyata, Toshio; Schrag, Deborah; Takeuchi, Masahiro; Uyama, Yoshiaki; Zhao, Lihui; Skali, Hicham; Solomon, Scott; Jacobus, Susanna; Hughes, Michael; Packer, Milton; Wei, Lee-Jen

    2014-08-01

    In a longitudinal clinical study to compare two groups, the primary end point is often the time to a specific event (eg, disease progression, death). The hazard ratio estimate is routinely used to empirically quantify the between-group difference under the assumption that the ratio of the two hazard functions is approximately constant over time. When this assumption is plausible, such a ratio estimate may capture the relative difference between two survival curves. However, the clinical meaning of such a ratio estimate is difficult, if not impossible, to interpret when the underlying proportional hazards assumption is violated (ie, the hazard ratio is not constant over time). Although this issue has been studied extensively and various alternatives to the hazard ratio estimator have been discussed in the statistical literature, such crucial information does not seem to have reached the broader community of health science researchers. In this article, we summarize several critical concerns regarding this conventional practice and discuss various well-known alternatives for quantifying the underlying differences between groups with respect to a time-to-event end point. The data from three recent cancer clinical trials, which reflect a variety of scenarios, are used throughout to illustrate our discussions. When there is not sufficient information about the profile of the between-group difference at the design stage of the study, we encourage practitioners to consider a prespecified, clinically meaningful, model-free measure for quantifying the difference and to use robust estimation procedures to draw primary inferences. PMID:24982461

  3. The Old-Age Healthy Dependency Ratio in Europe.

    PubMed

    Muszyńska, Magdalena M; Rau, Roland

    2012-09-01

    The aim of this study is to answer the question of whether improvements in the health of the elderly in European countries could compensate for population ageing on the supply side of the labour market. We propose a state-of-health-specific (additive) decomposition of the old-age dependency ratio into an old-age healthy dependency ratio and an old-age unhealthy dependency ratio in order to participate in a discussion of the significance of changes in population health to compensate for the ageing of the labour force. Applying the proposed indicators to the Eurostat's population projection for the years 2010-2050, and assuming there will be equal improvements in life expectancy and healthy life expectancy at birth, we discuss various scenarios concerning future of the European labour force. While improvements in population health are anticipated during the years 2010-2050, the growth in the number of elderly people in Europe may be expected to lead to a rise in both healthy and unhealthy dependency ratios. The healthy dependency ratio is, however, projected to make up the greater part of the old-age dependency ratio. In the European countries in 2006, the value of the old-age dependency ratio was 25. But in the year 2050, with a positive migration balance over the years 2010-2050, there would be 18 elderly people in poor health plus 34 in good health per 100 people in the current working age range of 15-64. In the scenarios developed in this study, we demonstrate that improvements in health and progress in preventing disability will not, by themselves, compensate for the ageing of the workforce. However, coupled with a positive migration balance, at the level and with the age structure assumed in the Eurostat's population projections, these developments could ease the effect of population ageing on the supply side of the European labour market.

  4. A balanced hazard ratio for risk group evaluation from survival data.

    PubMed

    Branders, Samuel; Dupont, Pierre

    2015-07-30

    Common clinical studies assess the quality of prognostic factors, such as gene expression signatures, clinical variables or environmental factors, and cluster patients into various risk groups. Typical examples include cancer clinical trials where patients are clustered into high or low risk groups. Whenever applied to survival data analysis, such groups are intended to represent patients with similar survival odds and to select the most appropriate therapy accordingly. The relevance of such risk groups, and of the related prognostic factors, is typically assessed through the computation of a hazard ratio. We first stress three limitations of assessing risk groups through the hazard ratio: (1) it may promote the definition of arbitrarily unbalanced risk groups; (2) an apparently optimal group hazard ratio can be largely inconsistent with the p-value commonly associated to it; and (3) some marginal changes between risk group proportions may lead to highly different hazard ratio values. Those issues could lead to inappropriate comparisons between various prognostic factors. Next, we propose the balanced hazard ratio to solve those issues. This new performance metric keeps an intuitive interpretation and is as simple to compute. We also show how the balanced hazard ratio leads to a natural cut-off choice to define risk groups from continuous risk scores. The proposed methodology is validated through controlled experiments for which a prescribed cut-off value is defined by design. Further results are also reported on several cancer prognosis studies, and the proposed methodology could be applied more generally to assess the quality of any prognostic markers.

  5. Calibrating recruitment estimates for mourning doves from harvest age ratios

    USGS Publications Warehouse

    Miller, David A.; Otis, David L.

    2010-01-01

    We examined results from the first national-scale effort to estimate mourning dove (Zenaida macroura) age ratios and developed a simple, efficient, and generalizable methodology for calibrating estimates. Our method predicted age classes of unknown-age wings based on backward projection of molt distributions from fall harvest collections to preseason banding. We estimated 1) the proportion of late-molt individuals in each age class, and 2) the molt rates of juvenile and adult birds. Monte Carlo simulations demonstrated our estimator was minimally biased. We estimated model parameters using 96,811 wings collected from hunters and 42,189 birds banded during preseason from 68 collection blocks in 22 states during the 2005–2007 hunting seasons. We also used estimates to derive a correction factor, based on latitude and longitude of samples, which can be applied to future surveys. We estimated differential vulnerability of age classes to harvest using data from banded birds and applied that to harvest age ratios to estimate population age ratios. Average, uncorrected age ratio of known-age wings for states that allow hunting was 2.25 (SD 0.85) juveniles:adult, and average, corrected ratio was 1.91 (SD 0.68), as determined from harvest age ratios from an independent sample of 41,084 wings collected from random hunters in 2007 and 2008. We used an independent estimate of differential vulnerability to adjust corrected harvest age ratios and estimated the average population age ratio as 1.45 (SD 0.52), a direct measure of recruitment rates. Average annual recruitment rates were highest east of the Mississippi River and in the northwestern United States, with lower rates between. Our results demonstrate a robust methodology for calibrating recruitment estimates for mourning doves and represent the first large-scale estimates of recruitment for the species. Our methods can be used by managers to correct future harvest survey data to generate recruitment estimates for use in

  6. Cumulative Hazard Ratio Estimation for Treatment Regimes in Sequentially Randomized Clinical Trials

    PubMed Central

    Tang, Xinyu; Wahed, Abdus S.

    2014-01-01

    The proportional hazards model is widely used in survival analysis to allow adjustment for baseline covariates. The proportional hazard assumption may not be valid for treatment regimes that depend on intermediate responses to prior treatments received, and it is not clear how such a model can be adapted to clinical trials employing more than one randomization. Besides, since treatment is modified post-baseline, the hazards are unlikely to be proportional across treatment regimes. Although Lokhnygina and Helterbrand (Biometrics 63: 422–428, 2007) introduced the Cox regression method for two-stage randomization designs, their method can only be applied to test the equality of two treatment regimes that share the same maintenance therapy. Moreover, their method does not allow auxiliary variables to be included in the model nor does it account for treatment effects that are not constant over time. In this article, we propose a model that assumes proportionality across covariates within each treatment regime but not across treatment regimes. Comparisons among treatment regimes are performed by testing the log ratio of the estimated cumulative hazards. The ratio of the cumulative hazard across treatment regimes is estimated using a weighted Breslow-type statistic. A simulation study was conducted to evaluate the performance of the estimators and proposed tests. PMID:26085847

  7. 230Th/U ages Supporting Hanford Site-Wide Probabilistic Seismic Hazard Analysis

    SciTech Connect

    Paces, James B.

    2014-08-31

    This product represents a USGS Administrative Report that discusses samples and methods used to conduct uranium-series isotope analyses and resulting ages and initial 234U/238U activity ratios of pedogenic cements developed in several different surfaces in the Hanford area middle to late Pleistocene. Samples were collected and dated to provide calibration of soil development in surface deposits that are being used in the Hanford Site-Wide probabilistic seismic hazard analysis conducted by AMEC. The report includes description of sample locations and physical characteristics, sample preparation, chemical processing and mass spectrometry, analytical results, and calculated ages for individual sites. Ages of innermost rinds on a number of samples from five sites in eastern Washington are consistent with a range of minimum depositional ages from 17 ka for cataclysmic flood deposits to greater than 500 ka for alluvium at several sites.

  8. 230Th/U ages Supporting Hanford Site‐Wide Probabilistic Seismic Hazard Analysis

    USGS Publications Warehouse

    Paces, James B.

    2014-01-01

    This product represents a USGS Administrative Report that discusses samples and methods used to conduct uranium-series isotope analyses and resulting ages and initial 234U/238U activity ratios of pedogenic cements developed in several different surfaces in the Hanford area middle to late Pleistocene. Samples were collected and dated to provide calibration of soil development in surface deposits that are being used in the Hanford Site-Wide probabilistic seismic hazard analysis conducted by AMEC. The report includes description of sample locations and physical characteristics, sample preparation, chemical processing and mass spectrometry, analytical results, and calculated ages for individual sites. Ages of innermost rinds on a number of samples from five sites in eastern Washington are consistent with a range of minimum depositional ages from 17 ka for cataclysmic flood deposits to greater than 500 ka for alluvium at several sites.

  9. Estimating the relative hazard by the ratio of logarithms of event-free proportions.

    PubMed

    Perneger, Thomas V

    2008-09-01

    Clinical trials typically examine associations between an intervention and the occurrence of a clinical event. The association is often reported as a relative risk, more rarely as an odds ratio. Unfortunately, when the scientific interest lies with the ratio of incidence rates, both these statistics are inaccurate: the odds ratio is too extreme, and the relative risk too conservative. These biases are particularly strong when the outcomes are common. This paper describes an alternative statistic, the ratio of logarithms of event-free proportions (or relative log survival), which is simple to compute yet unbiased vis-à-vis the relative hazard. A formula to compute the sampling error of this statistic is also provided. Multivariate analysis can be conducted using complementary log-log regression. Precise knowledge of event occurrence times is not required for these analyses. Relative log survival may be particularly useful for meta-analyses of trials in which the proportion of events varies between studies.

  10. New Horizons: Dietary protein, ageing and the Okinawan ratio.

    PubMed

    Le Couteur, David G; Solon-Biet, Samantha; Wahl, Devin; Cogger, Victoria C; Willcox, Bradley J; Willcox, D Craig; Raubenheimer, David; Simpson, Stephen J

    2016-07-01

    Nutrition has profound effects on ageing and lifespan. Caloric restriction is the major nutritional intervention that historically has been shown to influence lifespan and/or healthspan in many animal models. Studies have suggested that a reduction in protein intake can also increase lifespan, albeit not as dramatically as caloric restriction. More recent research based on nutritional geometry has attempted to define the effects of nutrition on ageing over a broad landscape of dietary macronutrients and energy content. Such studies in insects and mice indicate that animals with ad libitum access to low-protein, high-carbohydrate diets have longest lifespans. Remarkably, the optimum content and ratio of dietary protein to carbohydrates for ageing in experimental animals are almost identical to those in the traditional diets of the long-lived people on the island of Okinawa. PMID:27130207

  11. Can environmental or occupational hazards alter the sex ratio at birth? A systematic review

    PubMed Central

    Terrell, Metrecia L.; Hartnett, Kathleen P.; Marcus, Michele

    2011-01-01

    More than 100 studies have examined whether environmental or occupational exposures of parents affect the sex ratio of their offspring at birth. For this review, we searched Medline and Web of Science using the terms ‘sex ratio at birth’ and ‘sex ratio and exposure’ for all dates, and reviewed bibliographies of relevant studies to find additional articles. This review focuses on exposures that have been the subject of at least four studies including polychlorinated biphenyls (PCBs), dioxins, pesticides, lead and other metals, radiation, boron, and g-forces. For paternal exposures, only dioxins and PCBs were consistently associated with sex ratios higher or lower than the expected 1.06. Dioxins were associated with a decreased proportion of male births, whereas PCBs were associated with an increased proportion of male births. There was limited evidence for a decrease in the proportion of male births after paternal exposure to DBCP, lead, methylmercury, non-ionizing radiation, ionizing radiation treatment for childhood cancer, boron, or g-forces. Few studies have found higher or lower sex ratios associated with maternal exposures. Studies in humans and animals have found a reduction in the number of male births associated with lower male fertility, but the mechanism by which environmental hazards might change the sex ratio has not yet been established. PMID:24149027

  12. Mark-specific Hazard Ratio Model with Multivariate Continuous Marks: An Application to Vaccine Efficacy

    PubMed Central

    Gilbert, P. B.

    2014-01-01

    Summary In randomized placebo-controlled preventive HIV vaccine efficacy trials, an objective is to evaluate the relationship between vaccine efficacy to prevent infection and genetic distances of the exposing HIV strains to the multiple HIV sequences included in the vaccine construct, where the set of genetic distances is considered as the continuous multivariate ‘mark’ observed in infected subjects only. This research develops a multivariate mark-specific hazard ratio model in the competing risks failure time analysis framework for the assessment of mark-specific vaccine efficacy. It allows improved efficiency of estimation by employing the semiparametric method of maximum profile likelihood estimation in the vaccine-to-placebo mark density ratio model. The model also enables the use of a more efficient estimation method for the overall log hazard ratio in the Cox model. Additionally, we propose testing procedures to evaluate two relevant hypotheses concerning mark-specific vaccine efficacy. The asymptotic properties and finite-sample performance of the inferential procedures are investigated. Finally, we apply the proposed methods to data collected in the Thai RV144 HIV vaccine efficacy trial. PMID:23421613

  13. The performance of different propensity score methods for estimating marginal hazard ratios.

    PubMed

    Austin, Peter C

    2013-07-20

    Propensity score methods are increasingly being used to reduce or minimize the effects of confounding when estimating the effects of treatments, exposures, or interventions when using observational or non-randomized data. Under the assumption of no unmeasured confounders, previous research has shown that propensity score methods allow for unbiased estimation of linear treatment effects (e.g., differences in means or proportions). However, in biomedical research, time-to-event outcomes occur frequently. There is a paucity of research into the performance of different propensity score methods for estimating the effect of treatment on time-to-event outcomes. Furthermore, propensity score methods allow for the estimation of marginal or population-average treatment effects. We conducted an extensive series of Monte Carlo simulations to examine the performance of propensity score matching (1:1 greedy nearest-neighbor matching within propensity score calipers), stratification on the propensity score, inverse probability of treatment weighting (IPTW) using the propensity score, and covariate adjustment using the propensity score to estimate marginal hazard ratios. We found that both propensity score matching and IPTW using the propensity score allow for the estimation of marginal hazard ratios with minimal bias. Of these two approaches, IPTW using the propensity score resulted in estimates with lower mean squared error when estimating the effect of treatment in the treated. Stratification on the propensity score and covariate adjustment using the propensity score result in biased estimation of both marginal and conditional hazard ratios. Applied researchers are encouraged to use propensity score matching and IPTW using the propensity score when estimating the relative effect of treatment on time-to-event outcomes.

  14. Age at marriage, sex-ratios, and ethnic heterogamy.

    PubMed

    Stier, H; Shavit, Y

    1994-05-01

    "This paper focuses on the effects of age at marriage and the sex-ratio on patterns of ethnic homogamy among Israeli women. We hypothesize that later marriages are more likely than early marriages to be heterogamous as the 'marriage market' shifts from school to the work-place. By the same token, when facing severe marriage squeezes women will be forced to out-marry. Employing data from the 1983 census, we model mate selection of women from Afro-Asian and Euro-American origin in various birth-cohorts. The results do not fully support our hypotheses: we find that in and of itself, age at marriage does not enhance ethnic heterogamy."

  15. Age effects in monetary valuation of reduced mortality risks: the relevance of age-specific hazard rates.

    PubMed

    Leiter, Andrea M

    2011-08-01

    This paper highlights the relevance of age-specific hazard rates in explaining the age variation in "value of statistical life" (VSL) figures. The analysis-which refers to a stated preference framework-contributes to the ongoing discussion of whether benefits resulting from reduced mortality risk should be valued differently depending on the age of the beneficiaries. By focussing on a life-threatening environmental phenomenon I show that the consideration of the individual's age-specific hazard rate is important. If a particular risk affects all individuals regardless of their age so that their hazard rate is age-independent, VSL is rather constant for people at different age; if hazard rate varies with age, VSL estimates are sensitive to age. The results provide an explanation for the mixed outcomes in empirical studies and illustrate in which cases an adjustment to age may or may not be justified. Efficient provision of live-saving measures requires that such differences to be taken into account.

  16. Age at marriage in Malaysia: a hazard model of marriage timing.

    PubMed

    Anderson, K H; Hill, M A; Butler, J S

    1987-08-01

    "This paper estimates a proportional hazards model for the timing of age at marriage of women in Malaysia. We hypothesize that age at marriage responds significantly to differences in male and female occupations, race, and age. We find considerable empirical support for the relevance of economic variables in determining age at marriage as well as evidence of strong differences in marriage patterns across races." PMID:12280709

  17. Job Loss, Unemployment and the Incidence of Hazardous Drinking during the Late 2000s Recession in Europe among Adults Aged 50–64 Years

    PubMed Central

    Bosque-Prous, Marina; Espelt, Albert; Sordo, Luis; Guitart, Anna M.; Brugal, M. Teresa; Bravo, Maria J.

    2015-01-01

    Background To estimate the incidence of hazardous drinking in middle-aged people during an economic recession and ascertain whether individual job loss and contextual changes in unemployment influence the incidence rate in that period. Methods Longitudinal study based on two waves of the SHARE project (Survey of Health, Ageing and Retirement in Europe). Individuals aged 50–64 years from 11 European countries, who were not hazardous drinkers at baseline (n = 7,615), were selected for this study. We estimated the cumulative incidence of hazardous drinking (≥40g and ≥20g of pure alcohol on average in men and women, respectively) between 2006 and 2012. Furthermore, in the statistical analysis, multilevel Poisson regression models with robust variance were fitted and obtained Risk Ratios (RR) and their 95% Confidence Intervals (95%CI). Results Over a 6-year period, 505 subjects became hazardous drinkers, with cumulative incidence of 6.6 per 100 persons between 2006 and 2012 (95%CI:6.1–7.2). Age [RR = 1.02 (95%CI:1.00–1.04)] and becoming unemployed [RR = 1.55 (95%CI:1.08–2.23)] were independently associated with higher risk of becoming a hazardous drinker. Conversely, having poorer self-perceived health was associated with lower risk of becoming a hazardous drinker [RR = 0.75 (95%CI:0.60–0.95)]. At country-level, an increase in the unemployment rate during the study period [RR = 1.32 (95%CI:1.17–1.50)] and greater increases in the household disposable income [RR = 0.97 (95%CI:0.95–0.99)] were associated with risk of becoming a hazardous drinker. Conclusions Job loss among middle-aged individuals during the economic recession was positively associated with becoming a hazardous drinker. Changes in country-level variables were also related to this drinking pattern. PMID:26445239

  18. Age Estimation of African Lions Panthera leo by Ratio of Tooth Areas.

    PubMed

    White, Paula A; Ikanda, Dennis; Ferrante, Luigi; Chardonnet, Philippe; Mesochina, Pascal; Cameriere, Roberto

    2016-01-01

    Improved age estimation of African lions Panthera leo is needed to address a number of pressing conservation issues. Here we present a formula for estimating lion age to within six months of known age based on measuring the extent of pulp closure from X-rays, or Ratio Of tooth AReas (ROAR). Derived from measurements taken from lions aged 3-13 years for which exact ages were known, the formula explains 92% of the total variance. The method of calculating the pulp/tooth area ratio, which has been used extensively in forensic science, is novel in the study of lion aging. As a quantifiable measure, ROAR offers improved lion age estimates for population modeling and investigations of age-related mortality, and may assist national and international wildlife authorities in judging compliance with regulatory measures involving age.

  19. Age Estimation of African Lions Panthera leo by Ratio of Tooth Areas.

    PubMed

    White, Paula A; Ikanda, Dennis; Ferrante, Luigi; Chardonnet, Philippe; Mesochina, Pascal; Cameriere, Roberto

    2016-01-01

    Improved age estimation of African lions Panthera leo is needed to address a number of pressing conservation issues. Here we present a formula for estimating lion age to within six months of known age based on measuring the extent of pulp closure from X-rays, or Ratio Of tooth AReas (ROAR). Derived from measurements taken from lions aged 3-13 years for which exact ages were known, the formula explains 92% of the total variance. The method of calculating the pulp/tooth area ratio, which has been used extensively in forensic science, is novel in the study of lion aging. As a quantifiable measure, ROAR offers improved lion age estimates for population modeling and investigations of age-related mortality, and may assist national and international wildlife authorities in judging compliance with regulatory measures involving age. PMID:27089506

  20. Age Estimation of African Lions Panthera leo by Ratio of Tooth Areas

    PubMed Central

    Ikanda, Dennis; Ferrante, Luigi; Chardonnet, Philippe; Mesochina, Pascal; Cameriere, Roberto

    2016-01-01

    Improved age estimation of African lions Panthera leo is needed to address a number of pressing conservation issues. Here we present a formula for estimating lion age to within six months of known age based on measuring the extent of pulp closure from X-rays, or Ratio Of tooth AReas (ROAR). Derived from measurements taken from lions aged 3–13 years for which exact ages were known, the formula explains 92% of the total variance. The method of calculating the pulp/tooth area ratio, which has been used extensively in forensic science, is novel in the study of lion aging. As a quantifiable measure, ROAR offers improved lion age estimates for population modeling and investigations of age-related mortality, and may assist national and international wildlife authorities in judging compliance with regulatory measures involving age. PMID:27089506

  1. Determining the age of cats by pulp cavity/tooth width ratio using dental radiography

    PubMed Central

    Park, Kyoungsun; Ahn, Jaesang; Kang, Sunmee; Lee, Euiri; Kim, Soohyun; Park, Sangwan; Park, Sungwon; Noh, Hyunwoo

    2014-01-01

    The purpose of this study was to evaluate the effect of age on the ratio of pulp cavity/tooth width (P/T ratio) in healthy cats. The dental radiographs of 32 cats (16 males and 16 females) were generated with a digital dental X-ray unit with the animals under general anesthesia. Standardized measurement of the canine teeth was performed by drawing a line on the radiograph perpendicular to the cementoenamel junction (CEJ) of the tooth. There was an inversely proportional correlation between chronological age and the P/T ratio. Moreover, a strong Pearson squared correlation (γ2 = 0.92) was identified by the curved regression model. No significant differences in the P/T ratio based on gender or breed were found. These results suggest that determination of age by P/T ratio could be clinically useful for estimating the chronological age of cats. PMID:25234207

  2. Determining the age of cats by pulp cavity/tooth width ratio using dental radiography.

    PubMed

    Park, Kyoungsun; Ahn, Jaesang; Kang, Sunmee; Lee, Euiri; Kim, Soohyun; Park, Sangwan; Park, Sungwon; Noh, Hyunwoo; Seo, Kangmoon

    2014-12-01

    The purpose of this study was to evaluate the effect of age on the ratio of pulp cavity/tooth width (P/T ratio) in healthy cats. The dental radiographs of 32 cats (16 males and 16 females) were generated with a digital dental X-ray unit with the animals under general anesthesia. Standardized measurement of the canine teeth was performed by drawing a line on the radiograph perpendicular to the cemento- enamel junction (CEJ) of the tooth. There was an inversely proportional correlation between chronological age and the P/T ratio. Moreover, a strong Pearson squared correlation (γ(2) = 0.92) was identified by the curved regression model. No significant differences in the P/T ratio based on gender or breed were found. These results suggest that determination of age by P/T ratio could be clinically useful for estimating the chronological age of cats. PMID:25234207

  3. Gender differences in hazardous drinking among middle-aged in Europe: the role of social context and women’s empowerment

    PubMed Central

    Bosque-Prous, Marina; Borrell, Carme; Bartroli, Montse; Guitart, Anna M.; Villalbí, Joan R.; Brugal, M. Teresa

    2015-01-01

    Background: The aim of this study was to estimate the magnitude of gender differences in hazardous drinking among middle-aged people and to analyse whether these differences are associated with contextual factors, such as public policies or socioeconomic factors. Methods: Cross-sectional design. The study population included 50- to 64-year-old residents of 16 European countries who participated in the Survey of Health, Ageing and Retirement in Europe project conducted in 2010–12 (n = 26 017). We estimated gender differences in hazardous drinking in each country. To determine whether different social context or women’s empowerment variables were associated with gender differences in hazardous drinking, we fitted multilevel Poisson regression models adjusted for various individual and country-level variables, which yielded prevalence ratios and their 95% confidence intervals (95% CI). Results: Prevalence of hazardous drinking was significantly higher in men than women [30.2% (95% CI: 29.1–31.4%) and 18.6% (95% CI: 17.7–19.4%), respectively] in most countries, although the extent of these differences varied between countries. Among individuals aged 50–64 years in Europe, risk of becoming a hazardous drinker was 1.69 times higher (95% CI: 1.45–1.97) in men, after controlling for individual and country-level variables. We also found that lower values of the gender empowerment measure and higher unemployment rates were associated with higher gender differences in hazardous drinking. Conclusion: Countries with the greatest gender differences in hazardous drinking were those with the most restrictions on women’s behaviour, and the greatest gender inequalities in daily life. Lower gender differences in hazardous drinking seem to be related to higher consumption among women. PMID:25616593

  4. Sex ratio of equine offspring is affected by the ages of the mare and stallion.

    PubMed

    Santos, Marianna Machado; Maia, Leonardo Lara; Nobre, Daniel Magalhães; Oliveira Neto, José Ferraz; Garcia, Tiago Rezende; Lage, Maria Coeli Gomes Reis; de Melo, Maria Isabel Vaz; Viana, Walmir Santos; Palhares, Maristela Silveira; da Silva Filho, José Monteiro; Santos, Renato Lima; Valle, Guilherme Ribeiro

    2015-10-15

    The aim of this study was to determine the influence of parental age on the sex ratio of offspring in horses. Two trials were performed. In the first trial, the data from a randomly obtained population with a 1:1 sex ratio of 59,950 Mangalarga Marchador horses born in Brazil from 1990 to 2011 were analyzed. The sex ratios of the offspring were compared among groups according to the mare and the stallion ages (from 3 to 25 years). In the first step of the analysis, the mares and stallions were grouped according to age in 5-year intervals. In the second step, the groups were based on the parental age gap at conception. In the third step, the group of the mares and stallions with similar ages from the second step was subdivided, and the different parental age subgroups that were divided into 5-year intervals were compared. In the fourth step, the sex ratio of the offspring was determined according to the ages of the mares and the stallions at conception. The second trial was based on the data from 253 horses of several breeds that were born after natural gestation into a herd from 1989 to 2010, and the offspring of groups that were younger or older than 15 years were compared. The data from both trials were analyzed using a chi-square test (P ≤ 0.01 for the first trial; and P ≤ 0.05 for the second trial) for the comparisons of the sex ratios. In the first trial, the Spearman test (P ≤ 0.01) was used to verify the correlations between the parental age and the offspring sex ratio. In the first trial, the offspring sex ratio decreased as the mare or stallion age increased, and the decrease was more marked for the mares than for the stallions. In the second trial, the mares older than 15 years had more fillies than the younger mares, but the stallion age had no effect on the sex of the offspring. The first trial, with a large number of horses, revealed the pattern of the distribution of the sex ratios of offspring according to the parental age in horses, whereas the

  5. The Processing of Symbolic and Nonsymbolic Ratios in School-Age Children

    PubMed Central

    Meert, Gaëlle; Grégoire, Jacques; Seron, Xavier; Noël, Marie-Pascale

    2013-01-01

    This study tested the processing of ratios of natural numbers in school-age children. Nine- and eleven-year-olds were presented collections made up of orange and grey dots (i.e., nonsymbolic format) and fractions (i.e., symbolic format). They were asked to estimate ratios between the number of orange dots and the total number of dots and fractions by producing an equivalent ratio of surface areas (filling up a virtual glass). First, we tested whether symbolic notation of ratios affects their processing by directly comparing performance on fractions with that on dot sets. Second, we investigated whether children’s estimates of nonsymbolic ratios of natural numbers relied at least in part on ratios of surface areas by contrasting a condition in which the ratio of surface areas occupied by dots covaried with the ratio of natural numbers and a condition in which this ratio of surface areas was kept constant across ratios of natural numbers. The results showed that symbolic notation did not really have a negative impact on performance among 9-year-olds, while it led to more accurate estimates in 11-year-olds. Furthermore, in dot conditions, children’s estimates increased consistently with ratios between the number of orange dots and the total number of dots even when the ratio of surface areas was kept constant but were less accurate in that condition than when the ratio of surface areas covaried with the ratio of natural numbers. In summary, these results indicate that mental magnitude representation is more accurate when it is activated from symbolic ratios in children as young as 11 years old and that school-age children rely at least in part on ratios of surface areas to process nonsymbolic ratios of natural numbers when given the opportunity to do so. PMID:24312393

  6. Age estimation by pulp/tooth ratio in lower premolars by orthopantomography.

    PubMed

    Cameriere, Roberto; De Luca, Stefano; Alemán, Inmaculada; Ferrante, Luigi; Cingolani, Mariano

    2012-01-10

    Accurate age estimation has always been a problem for forensic scientists, and apposition of secondary dentine is often used as an indicator of age. Since 2004, in order to examine patterns of secondary dentine apposition, Cameriere et al. have been extensively studying the pulp/tooth area ratio of the canines by panoramic and peri-apical X-ray images. The main aim of this paper is to examine the relationship between age and age-related changes in the pulp/tooth area ratio in monoradicular teeth, with the exception of canines, by orthopantomography. A total of 606 orthopantomograms of Spanish white Caucasian patients (289 women and 317 men), aged between 18 and 75 years and coming from Bilbao and Granada (Spain), was analysed. Regression analysis of age of monoradicular teeth indicated that the lower premolars were the most closely correlated with age. An ANCOVA did not show significant differences between men and women. Multiple regression analysis, with age as dependent variable and pulp/tooth area ratio as predictor, yielded several formulae. R(2) ranged from 0.69 to 0.75 for a single lower premolar tooth and from 0.79 to 0.86 for multiple lower premolar teeth. Depending on the available number of premolar teeth, the mean of the absolute values of residual standard error, at 95% confidence interval, ranged between 4.34 and 6.02 years, showing that the pulp/tooth area ratio is a useful variable for assessing age with reasonable accuracy.

  7. Testing seismic hazard models with Be-10 exposure ages for precariously balanced rocks

    NASA Astrophysics Data System (ADS)

    Rood, D. H.; Anooshehpoor, R.; Balco, G.; Brune, J.; Brune, R.; Ludwig, L. Grant; Kendrick, K.; Purvance, M.; Saleeby, I.

    2012-04-01

    Currently, the only empirical tool available to test maximum earthquake ground motions spanning timescales of 10 ky-1 My is the use of fragile geologic features, including precariously balanced rocks (PBRs). The ages of PBRs together with their areal distribution and mechanical stability ("fragility") constrain probabilistic seismic hazard analysis (PSHA) over long timescales; pertinent applications include the USGS National Seismic Hazard Maps (NSHM) and tests for ground motion models (e.g., Cybershake). Until recently, age constraints for PBRs were limited to varnish microlamination (VML) dating techniques and sparse cosmogenic nuclide data; however, VML methods yield minimum limiting ages for individual rock surfaces, and the interpretations of cosmogenic nuclide data were ambiguous because they did not account for the exhumation history of the PBRs or the complex shielding of cosmic rays. We have recently published a robust method for the exposure dating of PBRs combining Be-10 profiles, a numerical model, and a three-dimensional model for each PBR constructed using photogrammetry (Balco et al., 2011, Quaternary Geochronology). Here, we use this method to calculate new exposure ages and fragilities for 6 PBRs in southern California (USA) near the San Andreas, San Jacinto, and Elsinore faults at the Lovejoy Buttes, Round Top, Pacifico, Beaumont South, Perris, and Benton Road sites (in addition to the recently published age of 18.7 +/- 2.8 ka for a PBR at the Grass Valley site). We combine our ages and fragilities for each PBR, and use these data to test the USGS 2008 NSHM PGA with 2% in 50 year probability, USGS 2008 PSHA deaggregations, and basic hazard curves from USGS 2002 NSHM data.

  8. Testing seismic hazard models with Be-10 exposure ages for precariously balanced rocks

    NASA Astrophysics Data System (ADS)

    Rood, D. H.; Anooshehpoor, R.; Balco, G.; Biasi, G. P.; Brune, J. N.; Brune, R.; Grant Ludwig, L.; Kendrick, K. J.; Purvance, M.; Saleeby, I.

    2012-12-01

    Currently, the only empirical tool available to test maximum earthquake ground motions spanning timescales of 10 ky-1 My is the use of fragile geologic features, including precariously balanced rocks (PBRs). The ages of PBRs together with their areal distribution and mechanical stability ("fragility") constrain probabilistic seismic hazard analysis (PSHA) over long timescales; pertinent applications include the USGS National Seismic Hazard Maps (NSHM) and tests for ground motion models (e.g., Cybershake). Until recently, age constraints for PBRs were limited to varnish microlamination (VML) dating techniques and sparse cosmogenic nuclide data; however, VML methods yield minimum limiting ages for individual rock surfaces, and the interpretations of cosmogenic nuclide data were ambiguous because they did not account for the exhumation history of the PBRs or the complex shielding of cosmic rays. We have recently published a robust method for the exposure dating of PBRs combining Be-10 profiles, a numerical model, and a three-dimensional shape model for each PBR constructed using photogrammetry (Balco et al., 2011, Quaternary Geochronology). Here, we use our published method to calculate new exposure ages for PBRs at 6 sites in southern California near the San Andreas, San Jacinto, and Elsinore faults, including: Lovejoy Buttes (9 +/- 1 ka), Round Top (35 +/- 1 ka), Pacifico (19 +/- 1 ka, but with a poor fit to data), Beaumont South (17 +/- 2 ka), Perris (24 +/- 2 ka), and Benton Road (40 +/- 1 ka), in addition to the recently published age of 18.5 +/- 2.0 ka for a PBR at the Grass Valley site. We combine our ages and fragilities for each PBR, and use these data to test the USGS 2008 NSHM PGA with 2% in 50 year probability, USGS 2008 PSHA deaggregations, and basic hazard curves from USGS 2002 NSHM data. Precariously balanced rock in southern California

  9. Age and Sex Ratios in a High-Density Wild Red-Legged Partridge Population

    PubMed Central

    Nadal, Jesús; Ponz, Carolina; Margalida, Antoni

    2016-01-01

    The dynamics of a wild red-legged partridge population were examined over a 14-year period in Spain to identify patterns in age and sex ratios in relation to weather parameters, and to assess the importance of these parameters in population dynamics and management. The results gave age ratios of 1.07 (but 2.13 in July counts), juvenile sex ratios of 1.01 and adult sex ratios of 1.47. Overall, 12% more females were hatched and female juvenile mortality was 7.3% higher than in males. Sex differential mortality explains the 19.2% deficit in adult females, which are more heavily predated than males during the breeding period. Accordingly, age ratios are dependent on sex ratios and both are density dependent. Over time, ratios and density changes appear to be influenced by weather and management. When the habitat is well conserved, partridge population dynamics can be explained by a causal chain: weather operates on net primary production, thereby affecting partridge reproduction and predation and, as a result, age and sex ratios in the October population. A reduction in the impact of predation (i.e. the effects of ground predators on eggs, chicks and breeding females) is the key factor to improve the conservation of partridge populations and associated biological processes. PMID:27508503

  10. Age and Sex Ratios in a High-Density Wild Red-Legged Partridge Population.

    PubMed

    Nadal, Jesús; Ponz, Carolina; Margalida, Antoni

    2016-01-01

    The dynamics of a wild red-legged partridge population were examined over a 14-year period in Spain to identify patterns in age and sex ratios in relation to weather parameters, and to assess the importance of these parameters in population dynamics and management. The results gave age ratios of 1.07 (but 2.13 in July counts), juvenile sex ratios of 1.01 and adult sex ratios of 1.47. Overall, 12% more females were hatched and female juvenile mortality was 7.3% higher than in males. Sex differential mortality explains the 19.2% deficit in adult females, which are more heavily predated than males during the breeding period. Accordingly, age ratios are dependent on sex ratios and both are density dependent. Over time, ratios and density changes appear to be influenced by weather and management. When the habitat is well conserved, partridge population dynamics can be explained by a causal chain: weather operates on net primary production, thereby affecting partridge reproduction and predation and, as a result, age and sex ratios in the October population. A reduction in the impact of predation (i.e. the effects of ground predators on eggs, chicks and breeding females) is the key factor to improve the conservation of partridge populations and associated biological processes. PMID:27508503

  11. Climate hazards, adaptation and "resilience" of societies (early Little Ice Age, west of France).

    NASA Astrophysics Data System (ADS)

    Athimon, Emmanuelle; Maanan, Mohamed

    2016-04-01

    Over the past ten to fifteen years, climate hazards and adaptation have received more attention due to the current climate change. Climate historians have gathered strong evidence that the world's climate has evolved over the past millennium and one of the most significant changes took place during the Little Ice Age. Recently, a set of questions has emerged: what were the effects of the Little Ice Age on human's societies? How did humans adapt to these climate changes? How did they react to extreme weather-related events? Using examples of climate hazards from the West of France during the beginning of the Little Ice Age (xivth-xviith centuries) such as storms, flooding, drought, harsh winters, the poster aims at showing how the past societies can constitute a source of inspiration for present ones. Through schemas, this research exposes the system's rebound capacity, points out the importance of the historical depth in research on human's adaptation and resilience and shows the value of integrating a historical approach. It reveals that History contributes to the knowledge of the relationship between societies and climate hazards. Data on climate hazards and adaptation of societies stem from historical sources such as chronicles, diaries, books of accounts, records of cities repairs. To protect themselves and their goods, medieval and modern societies had developed specific skills, practices and strategies. From the xivth to the xviiith century, there is an increase of defense by dikes in the low Loire, as for example the construction of those amongst Longué and Ponts-de-Cé between the early xivth century and 1407. The French kingdom's authorities also tried increasingly to provide technical, material, logistical and fiscal support: for instance, during the winter 1564-1565, several bridges have been destroyed by a river flooding in Nantes. The King Charles IX then offered to people of Nantes part of the funds from taxes on the main activities such as the

  12. Variations in pulp/tooth area ratio as an indicator of age: a preliminary study.

    PubMed

    Cameriere, Roberto; Ferrante, Luigi; Cingolani, Mariano

    2004-03-01

    This paper details a method for age determination of adults from single rooted teeth. The sample consisted of 100 Italian white Caucasian patients (46 men, 54 women) aged between 18 and 72 years. The single rooted maxillary right canine was utilized in this preliminary study. Pulp/root ration, tooth length, pulp/tooth length ratio, pulp/tooth area and pulp/root width ratios at three different levels were computed. Pearson's correlation coefficients between age and these variables showed that the ratio between pulp and tooth area correlated best with age (r2 = 0.85). Stepwise multiple regression models yielded a linear relationship between pulp/root width at mid-root level and chronological age and a linear relationship when pulp/tooth area was compared to age. Statistical analysis indicated that these two variables explain 84.9% of variations in estimated chronological age. The median of the absolute value of residual errors between actual and estimated ages was less than four years.

  13. Ratio

    NASA Astrophysics Data System (ADS)

    Webster, Nathan A. S.; Pownceby, Mark I.; Madsen, Ian C.; Studer, Andrew J.; Manuel, James R.; Kimpton, Justin A.

    2014-12-01

    Effects of basicity, B (CaO:SiO2 ratio) on the thermal range, concentration, and formation mechanisms of silico-ferrite of calcium and aluminum (SFCA) and SFCA-I iron ore sinter bonding phases have been investigated using an in situ synchrotron X-ray diffraction-based methodology with subsequent Rietveld refinement-based quantitative phase analysis. SFCA and SFCA-I phases are the key bonding materials in iron ore sinter, and improved understanding of the effects of processing parameters such as basicity on their formation and decomposition may assist in improving efficiency of industrial iron ore sintering operations. Increasing basicity significantly increased the thermal range of SFCA-I, from 1363 K to 1533 K (1090 °C to 1260 °C) for a mixture with B = 2.48, to ~1339 K to 1535 K (1066 °C to 1262 °C) for a mixture with B = 3.96, and to ~1323 K to 1593 K (1050 °C to 1320 °C) at B = 4.94. Increasing basicity also increased the amount of SFCA-I formed, from 18 wt pct for the mixture with B = 2.48 to 25 wt pct for the B = 4.94 mixture. Higher basicity of the starting sinter mixture will, therefore, increase the amount of SFCA-I, considered to be more desirable of the two phases. Basicity did not appear to significantly influence the formation mechanism of SFCA-I. It did, however, affect the formation mechanism of SFCA, with the decomposition of SFCA-I coinciding with the formation of a significant amount of additional SFCA in the B = 2.48 and 3.96 mixtures but only a minor amount in the highest basicity mixture. In situ neutron diffraction enabled characterization of the behavior of magnetite after melting of SFCA produced a magnetite plus melt phase assemblage.

  14. Bayesian Reconstruction of Two-Sex Populations by Age: Estimating Sex Ratios at Birth and Sex Ratios of Mortality1

    PubMed Central

    Wheldon, Mark C.; Raftery, Adrian E.; Clark, Samuel J.; Gerland, Patrick

    2014-01-01

    Summary The original version of Bayesian reconstruction, a method for estimating age-specific fertility, mortality, migration and population counts of the recent past with uncertainty, produced estimates for female-only populations. Here we show how two-sex populations can be similarly reconstructed and probabilistic estimates of various sex ratio quantities obtained. We demonstrate the method by reconstructing the populations of India from 1971 to 2001, Thailand from 1960 to 2000, and Laos from 1985 to 2005. We found evidence that in India, sex ratio at birth exceeded its conventional upper limit of 1.06, and, further, increased over the period of study, with posterior probability above 0.9. In addition, almost uniquely, we found evidence that life expectancy at birth (e0) was lower for females than for males in India (posterior probability for 1971–1976 equal to 0.79), although there was strong evidence for a narrowing of the gap through to 2001. In both Thailand and Laos, we found strong evidence for the more usual result that e0 was greater for females and, in Thailand, that the difference increased over the period of study. PMID:26612972

  15. Offspring sex ratio in red-winged blackbirds is dependent on maternal age.

    PubMed

    Blank, J L; Nolan, V

    1983-10-01

    In a marsh-breeding population of red-winged blackbirds, the sex ratio of offspring that survived to leave the nest varied with maternal age. Old mothers produced an excess of male fledglings, middle-aged mothers produced almost equal proportions of males and females, and young mothers produced nearly twice as many females as males. More males than females hatched from the eggs of old mothers, whereas among newly hatched progeny of middle-aged and young mothers the sex ratio did not differ from unity. The hatching rate of eggs of old mothers was unusually low, suggesting that the biased sex ratio of their hatchlings may have been caused by more frequent death of female embryos, although other possibilities can be imagined. Starvation of nestlings after hatching also affected the sex ratio among young that left the nest. When starvation occurred, it fell principally on young produced by the last and next-to-last eggs laid in the clutch. Because old mothers allocated relatively more energy to those eggs than to earlier-laid eggs, whereas young mothers apportioned energy equally to their eggs, few nestlings of old mothers but many nestlings of young mothers starved. Most nestlings that died were male. It followed that the male bias in sex ratio of progeny of old mothers did not change between hatching and nestleaving, but the ratio among progeny of young mothers shifted after hatching to a strong bias favoring females at nest-leaving.

  16. Auditory brainstem response in neonates: influence of gender and weight/gestational age ratio

    PubMed Central

    Angrisani, Rosanna M. Giaffredo; Bautzer, Ana Paula D.; Matas, Carla Gentile; de Azevedo, Marisa Frasson

    2013-01-01

    OBJECTIVE: To investigate the influence of gender and weight/gestational age ratio on the Auditory Brainstem Response (ABR) in preterm (PT) and term (T) newborns. METHODS: 176 newborns were evaluated by ABR; 88 were preterm infants - 44 females (22 small and 22 appropriate for gestational age) and 44 males (22 small and 22 appropriate for gestational age). The preterm infants were compared to 88 term infants - 44 females (22 small and 22 appropriate for gestational age) and 44 males (22 small and 22 appropriate for gestational age). All newborns had bilateral presence of transient otoacoustic emissions and type A tympanometry. RESULTS: No interaural differences were found. ABR response did not differentiate newborns regarding weight/gestational age in males and females. Term newborn females showed statistically shorter absolute latencies (except on wave I) than males. This finding did not occur in preterm infants, who had longer latencies than term newborns, regardless of gender. CONCLUSIONS: Gender and gestational age influence term infants' ABR, with lower responses in females. The weight/gestational age ratio did not influence ABR response in either groups. PMID:24473955

  17. Cation-ratio dating: A new rock varnish age-determination technique

    NASA Astrophysics Data System (ADS)

    Dorn, Ronald I.

    1983-07-01

    Rock varnish coats many surfaces of geomorphic and archaeologic interest in arid lands. All varnish dating techniques are limited by the time lag between the exposure of a surface to subaerial processes and the onset of varnishing. They are valid only where manganese is not remobilized after deposition, for example, in most arid environments. The premise of a new age-determination method, cation-ratio dating, is that the ratio of the more mobile cations (e.g., K and Ca) to titanium in varnish decreases with time. Although there are many inherent assumptions and potential limitations, cation-ratio dating has been verified on relative age-sequences from a Death Valley debris cone, Negev Desert talus flatirons, and prehistoric lake levels at Searles Lake in California. Varnish cation ratios have been calibrated to independently dated surfaces in the Coso volcanic field and vicinity in California. Tentative absolute dates have been assigned to geomorphic surfaces in the Coso area. Cation ratios have been used to distinguish relative ages of archaeologic artifacts in southwestern North America and to demonstrate that varnish at the South Stoddard locality, Mojave Desert, did not form in 25 yr.

  18. Reliability in age determination by pulp/tooth ratio in upper canines in skeletal remains.

    PubMed

    Cameriere, Roberto; Brogi, Giuseppe; Ferrante, Luigi; Mirtella, Dora; Vultaggio, Claudia; Cingolani, Mariano; Fornaciari, Gino

    2006-07-01

    Estimation of age of skeletal remains is one of the most complex questions for anthropologists. The most common macroscopic methods are based on dental wear and histological evaluation of bone remodeling. These methods are often qualitative, require great technical expertise, and have proved inexact in the estimation of ages over 50 years. Certain dental methods investigate the apposition of secondary dentine, in the study of tooth cross-sections, and X-rays to study width, height, and pulp area. The primary author previously proposed a method of estimating the age of a living person based on the pulp/tooth ratio (PTR) method in the upper canines. The aim of the present study is to verify whether the PTR method can also be used to estimate the age at death of skeletal remains. This paper investigates the study of historical samples of known age as a means to validate the proposed method.

  19. Large-scale age-dependent skewed sex ratio in a sexually dimorphic avian scavenger.

    PubMed

    Lambertucci, Sergio A; Carrete, Martina; Donázar, José Antonio; Hiraldo, Fernando

    2012-01-01

    Age-dependent skewed sex ratios have been observed in bird populations, with adult males generally outnumbering females. This trend is mainly driven by higher female mortality, sometimes associated with anthropogenic factors. Despite the large amount of work on bird sex ratios, research examining the spatial stability of adult sex ratios is extremely scarce. The Andean condor (Vultur gryphus) is the only bird of prey with strong sexual dimorphism favouring males (males are 30% heavier than females). By examining data from most of its South-American range, we show that while the juvenile sex ratio is balanced, or even female-skewed, the sex ratio becomes increasing male-skewed with age, with adult males outnumbering females by >20%, and, in some cases by four times more. This result is consistent across regions and independent of the nature of field data. Reasons for this are unknown but it can be hypothesized that the progressive disappearance of females may be associated with mortality caused by anthropogenic factors. This idea is supported by the asymmetric habitat use by the two sexes, with females scavenging in more humanized areas. Whatever the cause, male-skewed adult sex ratios imply that populations of this endangered scavenger face higher risks of extinction than previously believed.

  20. Large-Scale Age-Dependent Skewed Sex Ratio in a Sexually Dimorphic Avian Scavenger

    PubMed Central

    Lambertucci, Sergio A.; Carrete, Martina; Donázar, José Antonio; Hiraldo, Fernando

    2012-01-01

    Age-dependent skewed sex ratios have been observed in bird populations, with adult males generally outnumbering females. This trend is mainly driven by higher female mortality, sometimes associated with anthropogenic factors. Despite the large amount of work on bird sex ratios, research examining the spatial stability of adult sex ratios is extremely scarce. The Andean condor (Vultur gryphus) is the only bird of prey with strong sexual dimorphism favouring males (males are 30% heavier than females). By examining data from most of its South-American range, we show that while the juvenile sex ratio is balanced, or even female-skewed, the sex ratio becomes increasing male-skewed with age, with adult males outnumbering females by >20%, and, in some cases by four times more. This result is consistent across regions and independent of the nature of field data. Reasons for this are unknown but it can be hypothesized that the progressive disappearance of females may be associated with mortality caused by anthropogenic factors. This idea is supported by the asymmetric habitat use by the two sexes, with females scavenging in more humanized areas. Whatever the cause, male-skewed adult sex ratios imply that populations of this endangered scavenger face higher risks of extinction than previously believed. PMID:23029488

  1. Large-scale age-dependent skewed sex ratio in a sexually dimorphic avian scavenger.

    PubMed

    Lambertucci, Sergio A; Carrete, Martina; Donázar, José Antonio; Hiraldo, Fernando

    2012-01-01

    Age-dependent skewed sex ratios have been observed in bird populations, with adult males generally outnumbering females. This trend is mainly driven by higher female mortality, sometimes associated with anthropogenic factors. Despite the large amount of work on bird sex ratios, research examining the spatial stability of adult sex ratios is extremely scarce. The Andean condor (Vultur gryphus) is the only bird of prey with strong sexual dimorphism favouring males (males are 30% heavier than females). By examining data from most of its South-American range, we show that while the juvenile sex ratio is balanced, or even female-skewed, the sex ratio becomes increasing male-skewed with age, with adult males outnumbering females by >20%, and, in some cases by four times more. This result is consistent across regions and independent of the nature of field data. Reasons for this are unknown but it can be hypothesized that the progressive disappearance of females may be associated with mortality caused by anthropogenic factors. This idea is supported by the asymmetric habitat use by the two sexes, with females scavenging in more humanized areas. Whatever the cause, male-skewed adult sex ratios imply that populations of this endangered scavenger face higher risks of extinction than previously believed. PMID:23029488

  2. Sex ratio at reproductive age: changes over the last century in the Italian population.

    PubMed

    Ulizzi, L; Astolfi, P; Zonta, L A

    2001-02-01

    The radical improvement in living conditions experienced in Italy during the last century caused a reduction in male extra-mortality during the prereproductive years. As a consequence, a progressive increase in the sex ratio at the beginning of the reproductive age (15-19 years) occurred, so that in recent times the sex ratio in the young adult population has approached the almost constant value of 1.06 observed at birth. We calculated that the sex composition would be the same in newborns and in young adults in about one generation: obviously, we have to assume that the sex differentials in mortality and migration are constant over time. The 1:1 equilibrium between sexes, which maximizes reproductive success, occurred in the 15-19 age group at the beginning of the century and shifted to the 30-35 age group in the 1990s. We compared the 1993-1995 sex ratios in different age groups in European Union countries and observed that in Italy as well as in other Mediterranean countries the numerical equality between sexes is reached at 30-35 years of age, while in north-central Europe it is reached later, approximately at the end of reproductive life.

  3. Age estimation by pulp/tooth ratio in canines by peri-apical X-rays.

    PubMed

    Cameriere, Roberto; Ferrante, Luigi; Belcastro, Maria Giovanna; Bonfiglioli, Benedetta; Rastelli, Elisa; Cingolani, Mariano

    2007-01-01

    Estimation of age in individuals has received considerable attention in forensic science, in which it is a widely used method for individual identification, together with paleo-demographic analyses to establish mortality patterns in past populations. The present investigation, which is a continuation of a previously published pilot study, was conducted to examine the possible application of the pulp/tooth area ratio by peri-apical images as an indicator of age at death. A total of 200 peri-apical X-rays of upper and lower canines were assembled from 57 male and 43 female skeletons of Caucasian origin, aged between 20 and 79 years. They belong to the Frassetto osteological collection of Sassari (Sardinia) and are housed in the Museum of Anthropology, Department of Experimental and Evolutionistic Biology, University of Bologna. For each skeleton, dental maturity was evaluated by measuring the pulp/tooth area ratio on upper (x(1)) and lower (x(2)) canines. Very good agreement was found between intraobserver measurements. Statistical analysis was performed in order to obtain multiple regression formulae for dental age calculation, with chronological age as dependent variable, and gender, and upper and lower canines as independent variables. Stepwise regression analysis showed that gender did not contribute significantly to the fit (p=0.881) whereas variables x(1) and x(2) and the first-order interaction between them did. These two variables explained 92.5% of variations in estimated chronological age and the residual standard error was 4.06 years. Lastly, two simple linear regression equations were obtained for age estimation using canines from the maxilla and mandible separately. Both models explained 86% of variations in estimated chronological age and allowed an age-at-death estimate with a residual standard error of about 5.4 years.

  4. A comparison of methods used to obtain age ratios of snow and Canada geese

    USGS Publications Warehouse

    Higgins, K.F.; Linder, R.L.; Springer, P.F.

    1969-01-01

    The validity of group counts, cannon-net catches, and hunter-bag checks for estimating productivity of lesser snow geese (Anser caerulescens caerulescens) and small Canada geese (Branta canadensis hutchinsii-parvipes complex) was studied at Sand Lake National Wildlife Refuge during the falls of 1965 and 1966. Age ratios of snow geese obtained from net-trapped samples were significantly higher (P < 0.01) than from group counts at the same site. Immature snow geese were shot in a significantly greater (P < 0.01) proportion than they existed in the population as determined by group counts. Cannon-net catches and hunter-bag checks of snow and Canada geese yielded age ratios which were biased because of behavioral characteristics of the geese. Immatures of both species were less wary of trap equipment and immature snow geese were more vulnerable to the gun than adults. It was believed that age ratios from group counts of snow geese were more representative of the population than those from net catches and hunter-bag checks. Sex ratios of net-trapped geese showed a preponderance of males for adult Canada and adult and immature snow geese, whereas females were predominant in the immature segment of Canada geese. Hunter selectivity of blue- or white-phase snow geese was not observed at Sand Lake Refuge. Differential vulnerability to hunting between snow and Canada geese resulted from differences m feeding-flight behavior.

  5. The Prodigies of The Albano Lake During Roman Age and Natural Hazard Assessment At Roma, Italy.

    NASA Astrophysics Data System (ADS)

    Funiciello, R.; Giordano, G.; de Rita, D.

    Roma is built just 20 km to the northwest of the Pleistocene Colli Albani volcano, but is believed not exposed to relevant natural hazards, except for the Tiber river flood- ings, and local amplification of seismic waves from distal earthquakes. This belief has generally induced modern historians and geologists to discard as SmythologicalT the & cedil;many references to natural prodigies that are reported by many Roman-age historians. Recent studies have demonstrated that the Albano maar, the youngest volcanic cen- tre of the Colli Albani volcano and presently filled by a 175 m deep lake, protracted its activity to the Holocene triggering several catastrophic lahar events, likely related to lake withdrawal, the deposits of which are exposed to the southwest of Roma and reach its periphery. This finding youngs the history of the volcano and makes it rele- vant to pre-historic settlements, which ScarefullyT avoided the Albano maar slopes up & cedil;to the Bronze age. What is still unknown, though, is whether the lake experienced such fluctuations and overspills during historic times. Several Roman authors such as Ti- tus Livius, Dionigi d'Alicarnasso, Plutarco, Germanico, and many others wrote about the then well known 398 BC prodigious event, when, during the war between Roma and the Etruscan city of Veio, the gods anger caused the sudden rise and overspill of the Albano lake, reported as unrelated to climatic events, and the destructive flooding of the countryside. After that event Romans actually built a tunnel-drain which still operates regulating the lake level at 293 m a.s.l., 70 m below the maar rim elevation. Should those chronicles be truthful, we can join the geologic observation of Holocene lahar deposits from lake withdrawal with historical lake withdrawals, reassessing the natural hazard for the city of Roma under a point of view never explored before. This paper carefully explores the historical credibility of the 398 BC lake overspill event and its

  6. Perinatal Exposure to Hazardous Air Pollutants and Autism Spectrum Disorders at Age 8

    PubMed Central

    Kalkbrenner, Amy E.; Daniels, Julie L.; Chen, Jiu-Chiuan; Poole, Charles; Emch, Michael; Morrissey, Joseph

    2010-01-01

    Background Hazardous air pollutants are plausible candidate exposures for autism spectrum disorders. They have been explored in recent studies for their role in the development of these disorders. Methods We used a prevalent case-control design to screen perinatal exposure to 35 hazardous air pollutants for further investigation in autism etiology. We included 383 children with autism spectrum disorders and, as controls, 2829 children with speech and language impairment. All participants were identified from the records-based surveillance of 8-year-old children conducted by the Autism and Developmental Disabilities Monitoring Network in North Carolina (for children born in 1994 and 1996) and West Virginia (born in 1992 and 1994). Exposures to ambient concentrations of metal, particulate, and volatile organic air pollutants in the census tract of the child’s birth residence were assigned from the 1996 National Air Toxics Assessment annual-average model. We estimated odds ratios (ORs) for autism spectrum disorders and corresponding 95% confidence intervals (CIs), comparing across the 20th and 80th percentiles of log-transformed hazardous air pollutant concentration among the selected controls, using semi-Bayes logistic models and adjusting for sampling variables (surveillance year and state), a priori demographic confounders from the birth certificate and census, and covarying air pollutants. Results We estimated many near-null ORs, including those for metals, established human neurodevelopmental toxicants, and several pollutants that were elevated in a similar study in California. Hazardous air pollutants with more precise and elevated OR estimates included methylene chloride, 1.4 (95% CI = 0.7–2.5), quinoline, 1.4 (1.0–2.2), and styrene, 1.8 (1.0–3.1). Conclusions Our screening design was limited by exposure misclassification of air pollutants and the use of an alternate developmental disorder as the control group, both of which may have biased results

  7. Age-related Shifts in Distortion Product Otoacoustic Emissions Peak-ratios and Amplitude Modulation Spectra

    PubMed Central

    Lai, Jesyin; Bartlett, Edward L.

    2015-01-01

    Amplitude modulation (AM) is an important temporal cue for precise speech and complex sound recognition. However, functional decline of the auditory periphery as well as degradation of central auditory processing due to aging can reduce the salience and resolution of temporal cues. Age-related deficits in central temporal processing have previously been observed at more rapid AM frequencies and various AM depths. These centrally observed changes result from cochlear changes compounded with changes along the ascending auditory pathway. In fact, a decrease in ability to detect temporally modulated sounds accurately could originate from changes in cochlear filtering properties and in cochlear mechanics due to aging. Nonetheless, few studies have examined cochlear mechanisms in AM detection. To assess integrity of the mechanical properties of the auditory periphery, distortion product otoacoustic emissions (DPOAEs) are a tool commonly used in clinics and in research. In this study, we measured DPOAEs to reveal age-related changes in peak f2/f1 ratio and degradation in AM detection by basilar membrane vibration. Two tones (f1 and f2, f2>f1) at various f2/f1 ratios and simultaneous presentation of one AM and one pure tone were used as stimuli to evoke DPOAEs. In addition of observing reduced DPOAE amplitudes and steeper slopes in the input-output DPOAE functions, higher peak f2/f1 ratios and broader f2/f1 tuning were also observed in aged animals. Aged animals generally had lower distortion product (DP) and first sideband (SB 1) responses evoked by an f1 pure tone and an f2 AM tone, regardless of whether the AM frequency was 45 Hz or 128 Hz. SB 1 thresholds, which corresponds to the smallest stimulus AM depth that can induce cochlear vibrations at the DP generator locus, were higher in aged animals as well. The results suggest that age-related changes in peak f2/f1 ratio and AM detection by basilar membrane vibration are consistent with a reduction in endocochlear

  8. Hazard Ratio and Repeat Injury for Dementia in Patients With and Without a History of Traumatic Brain Injury: A Population-Based Secondary Data Analysis in Taiwan.

    PubMed

    Chu, Shu-Fen; Chiu, Wen-Ta; Lin, Hui-Wen; Chiang, Yung-Hsiao; Liou, Tsan-Hon

    2016-09-01

    The impact of traumatic brain injury (TBI) on the pathogenic hazard ratio (HR) for dementia patients is still controversial. Some studies have supported the association between TBI and dementia, especially for Alzheimer's disease, and our study determined that the HR of dementia patients with and without a history of TBI or repeated TBI (RTBI). We determined the HR for dementia patients with a diagnosis of TBI (n = 12931) and a comparative cohort with age- and gender-matched controls (n = 51724) during 2004-2005, using Taiwan's National Health Insurance Research Database. The adjusted HR (HR = 3.21) for dementia patients with TBI showed that they were more likely to develop dementia than the comparison cohort. The HR for dementia patients with RTBI was increased to 3.62. The results of this large-scale study suggested that TBI increases dementia risk. Future studies using animal models and epidemiological databases could elucidate medical and biological mechanisms linking TBI and the development of dementia. PMID:27614252

  9. A Stochastic Version of the Brass PF Ratio Adjustment of Age-Specific Fertility Schedules

    PubMed Central

    Baker, Jack; Alcantara, Adélamar; Ruan, Xiaomin

    2011-01-01

    Estimates of age-specific fertility rates based on survey data are known to suffer down-bias associated with incomplete reporting. Previously, William Brass (1964, 1965, 1968) proposed a series of adjustments of such data to reflect more appropriate levels of fertility through comparison with data on children-ever-born by age, a measure of cohort-specific cumulative fertility. His now widely-used Parity/Fertility or PF ratio method makes a number of strong assumptions, which have been the focus of an extended discussion in the literature on indirect estimation. However, while it is clear that the measures used in making adjusted age-specific fertility estimates with this method are captured with statistical uncertainty, little discussion of the nature of this uncertainty around PF-ratio based estimates of fertility has been entertained in the literature. Since both age-specific risk of childbearing and cumulative parity (children ever born) are measured with statistical uncertainty, an unknown credibility interval must surround every PF ratio-based estimate. Using the standard approach, this is unknown, limiting the ability to make statistical comparisons of fertility between groups or to understand stochasticity in population dynamics. This paper makes use of approaches applied to similar problems in engineering, the natural sciences, and decision analysis—often discussed under the title of uncertainty analysis or stochastic modeling—to characterize this uncertainty and to present a new method for making PF ratio-based fertility estimates with 95 percent uncertainty intervals. The implications for demographic analysis, between-group comparisons of fertility, and the field of statistical demography are explored. PMID:21829718

  10. The association between the ratio of monocytes:lymphocytes at age 3 months and risk of tuberculosis (TB) in the first two years of life

    PubMed Central

    2014-01-01

    Background Recent transcriptomic studies revived a hypothesis suggested by historical studies in rabbits that the ratio of peripheral blood monocytes to lymphocytes (ML) is associated with risk of tuberculosis (TB) disease. Recent data confirmed the hypothesis in cattle and in adults infected with HIV. Methods We tested this hypothesis in 1,336 infants (540 HIV-infected, 796 HIV-exposed, uninfected (HEU)) prospectively followed in a randomized controlled trial of isoniazid prophylaxis in Southern Africa, the IMPAACT P1041 study. We modeled the relationship between ML ratio at enrollment (91 to 120 days after birth) and TB disease or death in HIV-infected children and latent Mycobacterium tuberculosis (MTB) infection, TB disease or death in HEU children within 96 weeks (with 12 week window) of randomization. Infants were followed-up prospectively and routinely assessed for MTB exposure and outcomes. Cox proportional hazards models allowing for non-linear associations were used; in all cases linear models were the most parsimonious. Results Increasing ML ratio at baseline was significantly associated with TB disease/death within two years (adjusted hazard ratio (HR) 1.17 per unit increase in ML ratio; 95% confidence interval (CI) 1.01 to 1.34; P = 0.03). Neither monocyte count nor lymphocyte counts alone were associated with TB disease. The association was not statistically dissimilar between HIV infected and HEU children. Baseline ML ratio was associated with composite endpoints of TB disease and death and/or TB infection. It was strongest when restricted to probable and definite TB disease (HR 1.50; 95% CI 1.19 to 1.89; P = 0.006). Therefore, per 0.1 unit increase in the ML ratio at three to four months of age, the hazard of probable or definite TB disease before two years was increased by roughly 4% (95% CI 1.7% to 6.6%). Conclusion Elevated ML ratio at three- to four-months old is associated with increased hazards of TB disease before two years among

  11. Sex ratio of congenital abnormalities in the function of maternal age: a population-based study.

    PubMed

    Csermely, Gyula; Urbán, Robert; Czeizel, Andrew E; Veszprémi, Béla

    2015-05-01

    Maternal age effect is well-known in the origin of numerical chromosomal aberrations and some isolated congenital abnormalities (CAs). The sex ratio (SR), i.e. number of males divided by the number of males and females together, of most CAs deviates from the SR of newborn population (0.51). The objective of this analysis was to evaluate the possible association of maternal age with the SR of isolated CAs in a population-based large dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1996. First, SR of 24 CA entities/groups was estimated in 21,494 patients with isolated CA. In the next step SR of different maternal age groups was compared to the mean SR of the given CA-groups. The SR of four CA-groups showed some deviation in certain maternal age groups. Cases with anencephaly had female excess in young mothers (<25 years). Cases with skull's CAs particularly craniosynostosis had a male excess in cases born to women over 30 years. Two other CA groups (cleft lip ± palate and valvar pulmonic stenosis within the group of right-sided obstructive defect of heart) had significant deviation in SR of certain maternal age groups from the mean SR, but these deviations were not harmonized with joining age groups and thus were considered as a chance effect due to multiple testing. In conclusion, our study did not suggest that in general SR of isolated CAs might be modified by certain maternal age groups with some exception such as anencephaly and craniosynostosis.

  12. Sex ratio of congenital abnormalities in the function of maternal age: a population-based study.

    PubMed

    Csermely, Gyula; Urbán, Robert; Czeizel, Andrew E; Veszprémi, Béla

    2015-05-01

    Maternal age effect is well-known in the origin of numerical chromosomal aberrations and some isolated congenital abnormalities (CAs). The sex ratio (SR), i.e. number of males divided by the number of males and females together, of most CAs deviates from the SR of newborn population (0.51). The objective of this analysis was to evaluate the possible association of maternal age with the SR of isolated CAs in a population-based large dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1996. First, SR of 24 CA entities/groups was estimated in 21,494 patients with isolated CA. In the next step SR of different maternal age groups was compared to the mean SR of the given CA-groups. The SR of four CA-groups showed some deviation in certain maternal age groups. Cases with anencephaly had female excess in young mothers (<25 years). Cases with skull's CAs particularly craniosynostosis had a male excess in cases born to women over 30 years. Two other CA groups (cleft lip ± palate and valvar pulmonic stenosis within the group of right-sided obstructive defect of heart) had significant deviation in SR of certain maternal age groups from the mean SR, but these deviations were not harmonized with joining age groups and thus were considered as a chance effect due to multiple testing. In conclusion, our study did not suggest that in general SR of isolated CAs might be modified by certain maternal age groups with some exception such as anencephaly and craniosynostosis. PMID:25354028

  13. Parkinson disease male-to-female ratios increase with age: French nationwide study and meta-analysis

    PubMed Central

    Moisan, Frédéric; Kab, Sofiane; Mohamed, Fatima; Canonico, Marianne; Le Guern, Morgane; Quintin, Cécile; Carcaillon, Laure; Nicolau, Javier; Duport, Nicolas; Singh-Manoux, Archana; Boussac-Zarebska, Marjorie; Elbaz, Alexis

    2016-01-01

    Background Parkinson’s disease (PD) is 1.5 times more frequent in men than women. Whether age modifies this ratio is unclear. We examined whether male-to-female (M–F) ratios change with age through a French nationwide prevalence/incidence study (2010) and a meta-analysis of incidence studies. Methods We used French national drug claims databases to identify PD cases using a validated algorithm. We computed M–F prevalence/incidence ratios overall and by age using Poisson regression. Ratios were regressed on age to estimate their annual change. We identified all PD incidence studies with age/sex-specific data, and performed a meta-analysis of M–F ratios. Results On the basis of 149 672 prevalent (50% women) and 25 438 incident (49% women) cases, age-standardised rates were higher in men (prevalence=2.865/1000; incidence=0.490/1000 person-years) than women (prevalence=1.934/1000; incidence=0.328/1000 person-years). The overall M–F ratio was 1.48 for prevalence and 1.49 for incidence. Prevalence and incidence M–F ratios increased by 0.05 and 0.14, respectively, per 10 years of age. Incidence was similar in men and women under 50 years (M–F ratio <1.2, p>0.20), and over 1.6 (p<0.001) times higher in men than women above 80 years (p trend <0.001). A meta-analysis of 22 incidence studies (14 126 cases, 46% women) confirmed that M– F ratios increased with age (0.26 per 10 years, p trend=0.005). Conclusions Age-increasing M–F ratios suggest that PD aetiology changes with age. Sex-related risk/protective factors may play a different role across the continuum of age at onset. This finding may inform aetiological PD research. PMID:26701996

  14. Estimating age ratios and size of pacific walrus herds on coastal haulouts using video imaging.

    PubMed

    Monson, Daniel H; Udevitz, Mark S; Jay, Chadwick V

    2013-01-01

    During Arctic summers, sea ice provides resting habitat for Pacific walruses as it drifts over foraging areas in the eastern Chukchi Sea. Climate-driven reductions in sea ice have recently created ice-free conditions in the Chukchi Sea by late summer causing walruses to rest at coastal haulouts along the Chukotka and Alaska coasts, which provides an opportunity to study walruses at relatively accessible locations. Walrus age can be determined from the ratio of tusk length to snout dimensions. We evaluated use of images obtained from a gyro-stabilized video system mounted on a helicopter flying at high altitudes (to avoid disturbance) to classify the sex and age of walruses hauled out on Alaska beaches in 2010-2011. We were able to classify 95% of randomly selected individuals to either an 8- or 3-category age class, and we found measurement-based age classifications were more repeatable than visual classifications when using images presenting the correct head profile. Herd density at coastal haulouts averaged 0.88 walruses/m(2) (std. err. = 0.02), herd size ranged from 8,300 to 19,400 (CV 0.03-0.06) and we documented ∼30,000 animals along ∼1 km of beach in 2011. Within the herds, dependent walruses (0-2 yr-olds) tended to be located closer to water, and this tendency became more pronounced as the herd spent more time on the beach. Therefore, unbiased estimation of herd age-ratios will require a sampling design that allows for spatial and temporal structuring. In addition, randomly sampling walruses available at the edge of the herd for other purposes (e.g., tagging, biopsying) will not sample walruses with an age structure representative of the herd. Sea ice losses are projected to continue, and population age structure data collected with aerial videography at coastal haulouts may provide demographic information vital to ongoing efforts to understand effects of climate change on this species. PMID:23936106

  15. Estimating age ratios and size of Pacific walrus herds on coastal haulouts using video imaging

    USGS Publications Warehouse

    Monson, Daniel H.; Udevitz, Mark S.; Jay, Chadwick V.

    2013-01-01

    During Arctic summers, sea ice provides resting habitat for Pacific walruses as it drifts over foraging areas in the eastern Chukchi Sea. Climate-driven reductions in sea ice have recently created ice-free conditions in the Chukchi Sea by late summer causing walruses to rest at coastal haulouts along the Chukotka and Alaska coasts, which provides an opportunity to study walruses at relatively accessible locations. Walrus age can be determined from the ratio of tusk length to snout dimensions. We evaluated use of images obtained from a gyro-stabilized video system mounted on a helicopter flying at high altitudes (to avoid disturbance) to classify the sex and age of walruses hauled out on Alaska beaches in 2010–2011. We were able to classify 95% of randomly selected individuals to either an 8- or 3-category age class, and we found measurement-based age classifications were more repeatable than visual classifications when using images presenting the correct head profile. Herd density at coastal haulouts averaged 0.88 walruses/m2 (std. err. = 0.02), herd size ranged from 8,300 to 19,400 (CV 0.03–0.06) and we documented ~30,000 animals along ~1 km of beach in 2011. Within the herds, dependent walruses (0–2 yr-olds) tended to be located closer to water, and this tendency became more pronounced as the herd spent more time on the beach. Therefore, unbiased estimation of herd age-ratios will require a sampling design that allows for spatial and temporal structuring. In addition, randomly sampling walruses available at the edge of the herd for other purposes (e.g., tagging, biopsying) will not sample walruses with an age structure representative of the herd. Sea ice losses are projected to continue, and population age structure data collected with aerial videography at coastal haulouts may provide demographic information vital to ongoing efforts to understand effects of climate change on this species.

  16. Estimating age ratios and size of pacific walrus herds on coastal haulouts using video imaging.

    PubMed

    Monson, Daniel H; Udevitz, Mark S; Jay, Chadwick V

    2013-01-01

    During Arctic summers, sea ice provides resting habitat for Pacific walruses as it drifts over foraging areas in the eastern Chukchi Sea. Climate-driven reductions in sea ice have recently created ice-free conditions in the Chukchi Sea by late summer causing walruses to rest at coastal haulouts along the Chukotka and Alaska coasts, which provides an opportunity to study walruses at relatively accessible locations. Walrus age can be determined from the ratio of tusk length to snout dimensions. We evaluated use of images obtained from a gyro-stabilized video system mounted on a helicopter flying at high altitudes (to avoid disturbance) to classify the sex and age of walruses hauled out on Alaska beaches in 2010-2011. We were able to classify 95% of randomly selected individuals to either an 8- or 3-category age class, and we found measurement-based age classifications were more repeatable than visual classifications when using images presenting the correct head profile. Herd density at coastal haulouts averaged 0.88 walruses/m(2) (std. err. = 0.02), herd size ranged from 8,300 to 19,400 (CV 0.03-0.06) and we documented ∼30,000 animals along ∼1 km of beach in 2011. Within the herds, dependent walruses (0-2 yr-olds) tended to be located closer to water, and this tendency became more pronounced as the herd spent more time on the beach. Therefore, unbiased estimation of herd age-ratios will require a sampling design that allows for spatial and temporal structuring. In addition, randomly sampling walruses available at the edge of the herd for other purposes (e.g., tagging, biopsying) will not sample walruses with an age structure representative of the herd. Sea ice losses are projected to continue, and population age structure data collected with aerial videography at coastal haulouts may provide demographic information vital to ongoing efforts to understand effects of climate change on this species.

  17. Estimating Age Ratios and Size of Pacific Walrus Herds on Coastal Haulouts using Video Imaging

    PubMed Central

    Monson, Daniel H.; Udevitz, Mark S.; Jay, Chadwick V.

    2013-01-01

    During Arctic summers, sea ice provides resting habitat for Pacific walruses as it drifts over foraging areas in the eastern Chukchi Sea. Climate-driven reductions in sea ice have recently created ice-free conditions in the Chukchi Sea by late summer causing walruses to rest at coastal haulouts along the Chukotka and Alaska coasts, which provides an opportunity to study walruses at relatively accessible locations. Walrus age can be determined from the ratio of tusk length to snout dimensions. We evaluated use of images obtained from a gyro-stabilized video system mounted on a helicopter flying at high altitudes (to avoid disturbance) to classify the sex and age of walruses hauled out on Alaska beaches in 2010–2011. We were able to classify 95% of randomly selected individuals to either an 8- or 3-category age class, and we found measurement-based age classifications were more repeatable than visual classifications when using images presenting the correct head profile. Herd density at coastal haulouts averaged 0.88 walruses/m2 (std. err. = 0.02), herd size ranged from 8,300 to 19,400 (CV 0.03–0.06) and we documented ∼30,000 animals along ∼1 km of beach in 2011. Within the herds, dependent walruses (0–2 yr-olds) tended to be located closer to water, and this tendency became more pronounced as the herd spent more time on the beach. Therefore, unbiased estimation of herd age-ratios will require a sampling design that allows for spatial and temporal structuring. In addition, randomly sampling walruses available at the edge of the herd for other purposes (e.g., tagging, biopsying) will not sample walruses with an age structure representative of the herd. Sea ice losses are projected to continue, and population age structure data collected with aerial videography at coastal haulouts may provide demographic information vital to ongoing efforts to understand effects of climate change on this species. PMID:23936106

  18. Age- and speed-related differences in harmonic ratios during walking.

    PubMed

    Lowry, K A; Lokenvitz, N; Smiley-Oyen, A L

    2012-02-01

    Harmonic ratios (HRs), derived from trunk accelerations, measure smoothness of trunk motion during gait; higher ratios indicate greater smoothness. Previous research indicates that young adults optimize HRs at preferred pace, exhibiting reduced HRs at speeds faster and slower than preferred. Recent studies examining HRs and other trunk acceleration measures challenge this finding. The purpose of this study was to examine age-related differences in HRs across a range of self-selected overground walking speeds. Anteroposterior (AP), vertical (VT), and mediolateral (ML) HRs were examined in 13 young adults (ages 20-23), 13 healthy older adults (ages 60-69), and 13 healthy old-old adults (ages 80-86) while walking overground at very slow, slow, preferred, fast, and very fast speeds. Young and older adults exhibited similar HRs in all directions of motion across speeds, while old-old adults exhibited lower AP- and VT-HRs. All groups exhibited reduced HRs at speeds slower than preferred. However, there were no differences in HRs between preferred and faster speeds, with the exception of reduced VT-HRs in the very fast condition for the older groups. The ML-HR was not different between groups, and varied less across speeds. Stride time variability exhibited inverse relations with, and independently contributed to, HRs across speeds; lower stride time variability was associated with greater smoothness of trunk motion. Older groups were not disproportionately affected by walking more slowly and smoothness of trunk motion did not show a clear pattern of optimization at preferred pace for any group.

  19. Age estimation using pulp/tooth area ratio in maxillary canines-A digital image analysis

    PubMed Central

    Juneja, Manjushree; Devi, Yashoda B. K.; Rakesh, N.; Juneja, Saurabh

    2014-01-01

    Introduction: Determination of age of a subject is one of the most important aspects of medico-legal cases and anthropological research. Radiographs can be used to indirectly measure the rate of secondary dentine deposition which is depicted by reduction in the pulp area. Materials and Methods: In this study, 200 patients of Karnataka aged between 18-72 years were selected for the study. Panoramic radiographs were made and indirectly digitized. Radiographic images of maxillary canines (RIC) were processed using a computer-aided drafting program (ImageJ). The variables pulp/root length (p), pulp/tooth length (r), pulp/root width at enamel-cementum junction (ECJ) level (a), pulp/root width at mid-root level (c), pulp/root width at midpoint level between ECJ level and mid-root level (b) and pulp/tooth area ratio (AR) were recorded. All the morphological variables including gender were statistically analyzed to derive regression equation for estimation of age. Results: It was observed that 2 variables ‘AR’ and ‘b’ contributed significantly to the fit and were included in the regression model, yielding the formula: Age = 87.305−480.455(AR)+48.108(b). Statistical analysis indicated that the regression equation with selected variables explained 96% of total variance with the median of the residuals of 0.1614 years and standard error of estimate of 3.0186 years. Conclusion: There is significant correlation between age and morphological variables ‘AR’ and ‘b’ and the derived population specific regression equation can be potentially used for estimation of chronological age of individuals of Karnataka origin. PMID:25177137

  20. Feto-maternal heart rate ratio in pregnant bitches: effect of gestational age and maternal size.

    PubMed

    Alonge, S; Mauri, M; Faustini, M; Luvoni, G C

    2016-10-01

    Few information is available on parameters that can be used to objectively assess the foetal health during canine pregnancy. To identify a reliable parameter for the evaluation of foetal well-being, the effect of pre-gestational maternal bodyweight and gestational age on foetal heart rate (FHR) and on feto-maternal heart rate ratio (FHR/MHR) was investigated. Seventeen client-owned pregnant bitches of different pre-gestational maternal bodyweight were examined by serial echo colour Doppler. Only data from 11 uncomplicated pregnancies were included in the statistical analysis. The relationship between FHR, and FHR/MHR, and independent variables was analysed by polynomial regression (p ≤ .05). The FHR and the FHR/MHR significantly fitted a multiple quadratic regression for all independent variables. They both increased from 35 to 20 days before parturition and then a decreasing pattern followed. Higher values of both parameters were observed in bitches of lowest and highest bodyweight. Patterns of FHR and FHR/MHR were similar, but the ratio better describes the effect of the independent variables on the data. Thus, the highest significance of FHR/MHR compared to FHR alone encourages the application of this ratio to evaluate foetal well-being. The equation derived by the regression analysis of FHR/MHR could be applied in clinical practice to obtain its expected values in healthy pregnancies. PMID:27440379

  1. Dispersion of the ratios of cosmogenic isotopes of noble gases in chondrites of different cosmic-ray exposure ages

    NASA Technical Reports Server (NTRS)

    Alexeev, V. A.

    1993-01-01

    The dispersion of ratios of (He-3/Ne-21)c and (Ne-22/Ne-21)c depending on the cosmic-ray exposure ages of meteorites is analyzed. The dispersion is increased as age decreases. This effect may be stipulated by presence of a more significant portion of meteorites of small preatmospheric sizes among meteorites of small radiation ages in comparison to meteorites of higher exposure age.

  2. The Relationship between Neutrophil-to-lymphocyte Ratio and Age-related Macular Degeneration

    PubMed Central

    Ozer, Pinar Altiaylik

    2016-01-01

    Purpose To investigate the possible associations of neutrophil-to-lymphocyte ratio (NLR) and high sensitivity C-reactive protein (hs-CRP) level with age-related macular degeneration (ARMD). Methods Patients were divided to three groups of 40 patients with non-neovascular ARMD (group 1), 40 patients with neovascular ARMD (group 2), and 40 healthy control subjects (group 3). The neutrophil and lymphocyte counts were evaluated using an ABX Pentra DF120/USA biochemical analyzer, and hs-CRP levels were measured using a Beckman Coulter Immage 800. The NLR was measured by dividing neutrophil count by lymphocyte count. Results The patients in group 2 were older and more often diabetic than the patients in groups 1 and 3 (p < 0.001 and p < 0.001, respectively). The NLR level was 1.65 ± 0.71 in group 1, 1.98 ± 0.84 in group 2, and 1.46 ± 0.44 in group 3. The hs-CRP value was 1.98 ± 0.251 mg/L in group 1, 3.242 ± 0.211 mg/L in group 2, and 1.145 ± 0.193 mg/L in group 3. Both NLR and hs-CRP values were significantly higher in group 2 compared to group 3 (p = 0.002 and p = 0.002, respectively). In multivariate analysis, NLR remained an independent predictor of neovascular ARMD (odds ratio, 3.882; 95% confidence interval, 1.574 to 9.576; p = 0.003) together with age (p < 0.001), diabetes mellitus (p = 0.041), and hs-CRP (p = 0.018). Conclusions Our study suggests that increased NLR value is independently associated with neovascular ARMD. PMID:27729758

  3. Age-Ratios and Condition of En Route Migrant Blackpoll Warblers in the British Virgin Islands

    USGS Publications Warehouse

    Boal, Clint W.

    2014-01-01

    The en route migration ecology of Blackpoll Warblers (Setophaga striata) is poorly understood, yet intriguing. Blackpoll Warblers undertake the longest open water migration of any wood warbler species, traveling from northeastern North America to South America, with the first potential landfall being the West Indies. This migration requires substantial energy reserves and subjects Blackpoll Warblers to unpredictable weather events, which may influence survival. Few studies have examined age ratios or condition of Blackpoll Warblers while the warblers are en route through the Caribbean region. I captured and banded Blackpoll Warblers in the British Virgin Islands over 10 consecutive autumn migrations. Ratios of hatch-year to adult Blackpoll Warblers were variable but averaged lower than the ratios reported at continental departure locations. Average mass of Blackpoll Warblers was less than that reported at continental departure locations, with 26% of adults and 40% of hatch-year birds below the estimated fat free mass; hatch-year birds were consistently in poorer condition than adults. Blackpoll Warblers captured in the British Virgin Islands were also in poorer condition than those reported from the Dominican Republic and Barbados; this may be because of the British Virgin Islands being the first landfall after the transatlantic crossing, whereas Blackpoll Warblers arriving at the other Caribbean study locations may have had opportunities for stopover prior to arrival or have departed from farther south on the continent. However, this suggests that the British Virgin Islands likely provide important stopover habitat as a first landfall location for Blackpoll Warblers arriving from the transatlantic migration route.

  4. Hooked on a feeling: emotional labor as an occupational hazard of the post-industrial age.

    PubMed

    Andrews, Bonnie K; Karcz, Susan; Rosenberg, Beth

    2008-01-01

    Emotional labor is a subtle but serious occupational hazard that is likely to spread rapidly as the global service economy continues to grow. Emotional labor requires more than just acting friendly and being helpful to customers; the worker must manage his or her emotions to create a company-dictated experience for customers. The practice of emotional labor in an unsupportive work environment produces work-related stress, which has a wide range of potentially serious health effects. Though many employers do not acknowledge the existence of emotional labor, it is a real occupational hazard that may generate life-altering effects on physical and emotional health. While no official regulations or identification standards specify emotional labor as an occupational hazard, some guidelines exist regarding its outcome: occupational stress. Emotional labor should be recognized as an occupational hazard by the Occupational Safety and Health Administration (OSHA), but this hazard does not lend itself to regulation through standards. The business culture that demands its performance is questioned. PMID:18511400

  5. Hooked on a feeling: emotional labor as an occupational hazard of the post-industrial age.

    PubMed

    Andrews, Bonnie K; Karcz, Susan; Rosenberg, Beth

    2008-01-01

    Emotional labor is a subtle but serious occupational hazard that is likely to spread rapidly as the global service economy continues to grow. Emotional labor requires more than just acting friendly and being helpful to customers; the worker must manage his or her emotions to create a company-dictated experience for customers. The practice of emotional labor in an unsupportive work environment produces work-related stress, which has a wide range of potentially serious health effects. Though many employers do not acknowledge the existence of emotional labor, it is a real occupational hazard that may generate life-altering effects on physical and emotional health. While no official regulations or identification standards specify emotional labor as an occupational hazard, some guidelines exist regarding its outcome: occupational stress. Emotional labor should be recognized as an occupational hazard by the Occupational Safety and Health Administration (OSHA), but this hazard does not lend itself to regulation through standards. The business culture that demands its performance is questioned.

  6. Efficacy of the FEV1/FEV6 ratio compared to the FEV1/FVC ratio for the diagnosis of airway obstruction in subjects aged 40 years or over.

    PubMed

    Rosa, F W; Perez-Padilla, R; Camelier, A; Nascimento, O A; Menezes, A M B; Jardim, J R

    2007-12-01

    The present cross-sectional, population-based study was designed to evaluate the performance of the FEV1/FEV6 ratio for the detection of airway-obstructed subjects compared to the FEV1/FVC <0.70 fixed ratio test, as well as the lower limit of normality (LLN) for 1000 subjects (3)40 years of age in the metropolitan area of São Paulo, SP, Brazil. After the exclusion of 37 (3.7%) spirometries, a total of 963 pre-bronchodilator (BD) and 918 post-BD curves were constructed. The majority of the post-BD curves (93.1%) were of very good quality and achieved grade A (762 curves) or B (93 curves). The FEV1/FEV6 and FEV1/FVC ratios were highly correlated (r(2) = 0.92, P < 0.000). Two receiver operator characteristic curves were constructed in order to express the imbalance between the sensitivity and specificity of the FEV1/FEV6 ratio compared to two FEV1/FVC cut-off points for airway obstruction: equal to 70 (area under the curve = 0.98, P < 0.0001) and the LLN (area under the curve = 0.97, P < 0.0001), in the post-BD curves. According to an FEV1/FVC <0.70, the cut-off point for the FEV1/FEV6 ratio with the highest sum for sensitivity and specificity was 0.75. The FEV1/FEV6 ratio can be considered to be a good alternative to the FEV1/FVC ratio for the diagnosis of airway obstruction, both using a fixed cut-off point or below the LLN as reference. The FEV1/FEV6 ratio has the additional advantage of being an easier maneuver for the subjects and for the lung function technicians, providing a higher reproducibility than traditional spirometry maneuvers.

  7. Lead-uranium ratio of siliceous pitchblende from Great Bear Lake, N. W. T., Canada, and its possible age

    USGS Publications Warehouse

    Marble, J.P.

    1936-01-01

    1. A sample of pitchblende from LaBine Point, Echo Bay, Great Bear Lake, N. W. T., Canada, yields a "corrected" lead-ratio of 0.193, corresponding to an age of 1323 million years. 2. As the atomic weight and isotopic composition of the lead, and the Pa/UI ratio of this same sample have been determined, ages, etc., calculated by different methods should agree. This agreement has not been obtained in all instances, and possible reasons have been outlined. 3. The age found indicates that a possible Keewatin granite may be the source of the pitch-blende.

  8. Auger electron spectroscopy for the determination of sex and age related Ca/P ratio at different bone sites

    SciTech Connect

    Balatsoukas, Ioannis; Kourkoumelis, Nikolaos; Tzaphlidou, Margaret

    2010-10-15

    The Ca/P ratio of normal cortical and trabecular rat bone was measured by Auger electron spectroscopy (AES). Semiquantitative analysis was carried out using ratio techniques to draw conclusions on how age, sex and bone site affect the relative composition of calcium and phosphorus. Results show that Ca/P ratio is not sex dependent; quite the opposite, bone sites exhibit variations in elemental stoichiometry where femoral sections demonstrate higher Ca/P ratio than rear and front tibias. Age-related changes are more distinct for cortical bone in comparison with the trabecular bone. The latter's Ca/P ratio remains unaffected from all the parameters under study. This study confirms that AES is able to successfully quantify bone mineral main elements when certain critical points, related to the experimental conditions, are addressed effectively.

  9. Early-type galaxy archeology: Ages, abundance ratios, and effective temperatures from full-spectrum fitting

    SciTech Connect

    Conroy, Charlie; Graves, Genevieve J.; Van Dokkum, Pieter G.

    2014-01-01

    The stellar populations of galaxies hold vital clues to their formation histories. In this paper we present results based on modeling stacked spectra of early-type galaxies drawn from the Sloan Digital Sky Survey as a function of velocity dispersion, σ, from 90 km s{sup –1} to 300 km s{sup –1}. The spectra are of extremely high quality, with typical signal-to-noise ratio of 1000 Å{sup –1}, and a wavelength coverage of 4000 Å –8800 Å. Our population synthesis model includes variation in 16 elements from C to Ba, a two-component star formation history, the shift in effective temperature, Δ T {sub eff}, of the stars with respect to a solar metallicity isochrone, and the stellar initial mass function, among other parameters. In our approach we fit the full optical spectra rather than a select number of spectral indices and are able to, for the first time, measure the abundances of the elements V, Cr, Mn, Co, and Ni from the integrated light of distant galaxies. Our main results are as follows: (1) light-weighted stellar ages range from 6-12 Gyr from low to high σ; (2) [Fe/H] varies by less than 0.1 dex across the entire sample; (3) Mg closely tracks O, and both increase from ≈0.0 at low σ to ∼0.25 at high σ; Si and Ti show a shallower rise with σ, and Ca tracks Fe rather than O; (4) the iron peak elements V, Cr, Mn, and Ni track Fe, while Co tracks O, suggesting that Co forms primarily in massive stars; (5) C and N track O over the full sample and [C/Fe] and [N/Fe] exceed 0.2 at high σ; and (6) the variation in Δ T {sub eff} with total metallicity closely follows theoretical predictions based on stellar evolution theory. This last result is significant because it implies that we are robustly solving not only for the detailed abundance patterns but also the detailed temperature distributions (i.e., isochrones) of the stars in these galaxies. A variety of tests reveal that the systematic uncertainties in our measurements are probably 0.05 dex or

  10. Use of the p,p'-DDD: p,p'-DDE concentration ratio to trace contaminant migration from a hazardous waste site.

    PubMed

    Pinkney, Alfred E; McGowan, Peter C

    2006-09-01

    For approximately 50 years, beginning in the 1920s, hazardous wastes were disposed in an 11-hectare area of the Marine Corps Base (MCB) Quantico, Virginia, USA known as the Old Landfill. Polychlorinated biphenyls (PCBs) and DDT compounds were the primary contaminants of concern. These contaminants migrated into the sediments of a 78-hectare area of the Potomac River, the Quantico Embayment. Fish tissue contamination resulted in the MCB posting signs along the embayment shoreline warning fishermen to avoid consumption. In this paper, we interpret total PCB (t-PCBs) and total DDT (t-DDT, sum of six DDT, DDD, and DDE isomers) data from monitoring studies. We use the ratio of p,p'-DDD to p,p'-DDE concentrations as a tracer to distinguish site-related from regional contamination. The median DDD/DDE ratio in Quantico Embayment sediments (3.5) was significantly higher than the median ratio (0.71) in sediments from nearby Powells Creek, used as a reference area. In general, t-PCBs and t-DDT concentrations were significantly higher in killifish (Fundulus diaphanus) and carp (Cyprinus carpio) from the Quantico Embayment compared with Powells Creek. For both species, Quantico Embayment fish had mean or median DDD/DDE ratios greater than one. Median ratios were significantly higher in Quantico Embayment (4.6) than Powells Creek (0.28) whole body carp. In contrast, t-PCBs and t-DDT in channel catfish (Ictalurus punctatus) fillets were similar in Quantico Embayment and Powells Creek collections, with median ratios of 0.34 and 0.26, respectively. Differences between species may be attributable to movement (carp and killifish being more localized) and feeding patterns (carp ingesting sediment while feeding). We recommend that environmental scientists use this ratio when investigating sites with DDT contamination.

  11. Characterizing the aging of biomass burning organic aerosol by use of mixing ratios: a meta-analysis of four regions.

    PubMed

    Jolleys, Matthew D; Coe, Hugh; McFiggans, Gordon; Capes, Gerard; Allan, James D; Crosier, Jonathan; Williams, Paul I; Allen, Grant; Bower, Keith N; Jimenez, Jose L; Russell, Lynn M; Grutter, Michel; Baumgardner, Darrel

    2012-12-18

    Characteristic organic aerosol (OA) emission ratios (ERs) and normalized excess mixing ratios (NEMRs) for biomass burning (BB) events have been calculated from ambient measurements recorded during four field campaigns. Normalized OA mass concentrations measured using Aerodyne Research Inc. quadrupole aerosol mass spectrometers (Q-AMS) reveal a systematic variation in average values between different geographical regions. For each region, a consistent, characteristic ratio is seemingly established when measurements are collated from plumes of all ages and origins. However, there is evidence of strong regional and local-scale variability between separate measurement periods throughout the tropical, subtropical, and boreal environments studied. ERs close to source typically exceed NEMRs in the far-field, despite apparent compositional change and increasing oxidation with age. The absence of any significant downwind mass enhancement suggests no regional net source of secondary organic aerosol (SOA) from atmospheric aging of BB sources, in contrast with the substantial levels of net SOA formation associated with urban sources. A consistent trend of moderately reduced ΔOA/ΔCO ratios with aging indicates a small net loss of OA, likely as a result of the evaporation of organic material from initial fire emissions. Variability in ERs close to source is shown to substantially exceed the magnitude of any changes between fresh and aged OA, emphasizing the importance of fuel and combustion conditions in determining OA loadings from biomass burning. PMID:23163290

  12. Canine pulp ratios in estimating pensionable age in subjects with questionable documents of identification.

    PubMed

    Cameriere, Roberto; Ferrante, Luigi

    2011-03-20

    One of the most interesting reasons for needing to estimate age in adult subjects is to ascertain the age of a person of questionable pensionable age. This problem is becoming increasingly important in Europe, owing to the high number of immigrants without valid birth certificates. The aim of this paper is to evaluate the application of the apposition of secondary dentine of canines by the method of Cameriere et al. [10], in order to estimate the pensionable age of subjects without proper birth certificates. Periapical X-rays of 180 canines from 90 subjects aged between 50 and 79, 46 men and 44 women, were analysed. Estimated ages were used to test the medico-legal question as to whether an individual was older or younger than 65 years of age. In subjects under 65, age was correctly evaluated in 91% and 89% of individuals using maxillary and mandibular canines, respectively. In subjects over 65, of pensionable age, estimates were correct in 85% and 88% of cases, respectively. The proportion of individuals with correct classifications was 89% for both maxillary and mandibular canines taken together. In only four subjects, the results of maxillary and mandibular canines were discordant; in the other 86 subjects, the test of maxillary and mandibular canines yielded concordant results. Among the latter, the proportion of individuals who were really aged 65 years or older, and who were correctly estimated as such, was 94%, and the proportion of individuals younger than 65 years of age who were correctly estimated as such was 96%.

  13. Aged and Dependency Ratios among Autism, Intellectual Disability and Other Disabilities: 10-Year Trend Analysis

    ERIC Educational Resources Information Center

    Lin, Jin-Ding; Lin, Lan-Ping; Sung, Chang-Lin; Wu, Jia-Ling

    2011-01-01

    Dependency ratios are useful as general indicators of future economic and social health. The present paper focuses on the description of dependency ratios and over time change in different kind of disability which include autism, intellectual disability, vision, hearing, and limb impairments. We analyzed data mainly from the public web-access…

  14. The effects of aging on the dynamic adsorption of hazardous organic vapors on impregnated activated carbon.

    PubMed

    Amitay-Rosen, Tal; Leibman, Amir; Nir, Ido; Zaltsman, Amalia; Kaplan, Doron

    2015-01-01

    The effects of an eight-year natural aging of ASC impregnated activated carbon on the adsorption capacity and breakthrough times of model organic vapors and of the nerve agent sarin were investigated. Aging delayed methanol breakthrough from dry air on pre-dried carbon, but shortened the breakthrough time of both methanol and hexane under relative humidity (RH) of 30-85% on pre-humidified carbon. Aging also shortened the breakthrough time of the less volatile model compound 2-methoxyethanol, especially under RH of 60-85%. Aging significantly reduced the protection capacity against sarin at RH of 85%. The effects of aging on physisorption are attributed to enhanced hydrogen-bonding capability and strength of the interaction between water and adsorption sites on the carbon surface. PMID:25192468

  15. The effects of aging on the dynamic adsorption of hazardous organic vapors on impregnated activated carbon.

    PubMed

    Amitay-Rosen, Tal; Leibman, Amir; Nir, Ido; Zaltsman, Amalia; Kaplan, Doron

    2015-01-01

    The effects of an eight-year natural aging of ASC impregnated activated carbon on the adsorption capacity and breakthrough times of model organic vapors and of the nerve agent sarin were investigated. Aging delayed methanol breakthrough from dry air on pre-dried carbon, but shortened the breakthrough time of both methanol and hexane under relative humidity (RH) of 30-85% on pre-humidified carbon. Aging also shortened the breakthrough time of the less volatile model compound 2-methoxyethanol, especially under RH of 60-85%. Aging significantly reduced the protection capacity against sarin at RH of 85%. The effects of aging on physisorption are attributed to enhanced hydrogen-bonding capability and strength of the interaction between water and adsorption sites on the carbon surface.

  16. A biological hazard of our age: bracken fern [Pteridium aquilinum (L.) Kuhn]--a review.

    PubMed

    Vetter, János

    2009-03-01

    Bracken fern (Pteridium aquilinum) is the fifth most distributed common weed species of the world. Its ecological distribution is very wide, and the plant can grow and spread successfully on many types of soil. The cover of P. aquilinum is--in some cases--remarkable (e.g., in the United Kingdom). Bracken fern contains different poisonous agents: some cyanogen glycosides, factors (agents) of antithiamine character (thermolabile thiaminase and thermostable other compounds) and factors of carcinogenic activity (first of all ptaquiloside). This paper summarises and reviews different toxicological problems and poisonings caused by bracken fern in ruminants (cattle, sheep) and in non-ruminant animals (horses, pigs, rats, mice, etc.). The carcinogenic properties of the norsesquiterpene-type ptaquiloside make bracken fern a potent, living hazard. Recent investigations have shown that ptaquiloside pollution of different soil layers is a distinct possibility. Ptaquiloside may leach from the soil into the drinking water base. This ecotoxicological aspect seems to be the most hazardous phenomenon in relation to P. aquilinum and ptaquiloside. The carcinogenic effect of ptaquiloside is based on its hydrolysis, which leads to the formation of a dienon intermediate. It can produce DNA adducts, which are responsible for inducing carcinoma.

  17. Effects of Aging and Blood Contamination on the Urinary Protein–Creatinine Ratio in Captive Chimpanzees (Pan troglodytes)

    PubMed Central

    Lammey, Michael L; Ely, John J; Zavaskis, Tony; Videan, Elaine; Sleeper, Meg M

    2011-01-01

    The initial goal of this study was to evaluate proteinuria by using the protein to creatinine (UPC) ratio of urine obtained by cystocentesis of healthy adult captive chimpanzees. Urine samples were collected by using ultrasound-guided cystocentesis from 125 (80 male, 45 female) captive chimpanzees. All samples were collected over a 17-mo time period (August 2008 to January 2010) during the animal's annual physical examination. Samples were assayed at a veterinary diagnostic laboratory. Results indicated that both age and blood contamination affect the UPC ratio and therefore alter the diagnostic utility of the UPC ratio in chimpanzees. In addition, this research establishes reference ranges by age for the UPC ratio in healthy adult chimpanzees. Chimps younger than the median age of 24.6 y have a median UPC ratio of 0.098 (range, 0 to 1.76), whereas older animals have a median UPC of 0.288 (range, 0 to 2.44). Our results likely will enable veterinarians working with chimpanzees to better evaluate their renal function. PMID:21640034

  18. Effects of aging and blood contamination on the urinary protein-creatinine ratio in captive chimpanzees (Pan troglodytes).

    PubMed

    Lammey, Michael L; Ely, John J; Zavaskis, Tony; Videan, Elaine; Sleeper, Meg M

    2011-05-01

    The initial goal of this study was to evaluate proteinuria by using the protein to creatinine (UPC) ratio of urine obtained by cystocentesis of healthy adult captive chimpanzees. Urine samples were collected by using ultrasound-guided cystocentesis from 125 (80 male, 45 female) captive chimpanzees. All samples were collected over a 17-mo time period (August 2008 to January 2010) during the animal's annual physical examination. Samples were assayed at a veterinary diagnostic laboratory. Results indicated that both age and blood contamination affect the UPC ratio and therefore alter the diagnostic utility of the UPC ratio in chimpanzees. In addition, this research establishes reference ranges by age for the UPC ratio in healthy adult chimpanzees. Chimps younger than the median age of 24.6 y have a median UPC ratio of 0.098 (range, 0 to 1.76), whereas older animals have a median UPC of 0.288 (range, 0 to 2.44). Our results likely will enable veterinarians working with chimpanzees to better evaluate their renal function. PMID:21640034

  19. Aspect Ratio Plays a Role in the Hazard Potential of CeO2 Nanoparticles in Mouse Lung and Zebrafish Gastrointestinal Tract

    PubMed Central

    Lin, Sijie; Wang, Xiang; Ji, Zhaoxia; Chang, Chong Hyun; Dong, Yuan; Meng, Huan; Liao, Yu-Pei; Wang, Meiying; Song, Tze-Bin; Kohan, Sirus; Xia, Tian; Zink, Jeffrey I.; Lin, Shuo; Nel, André E.

    2014-01-01

    We have previously demonstrated that there is a relationship between the aspect ratio (AR) of CeO2 nanoparticles and in vitro hazard potential. CeO2 nanorods with AR ≥ 22 induced lysosomal damage and progressive effects on IL-1β production and cytotoxicity in the human myeloid cell line, THP-1. In order to determine whether this toxicological paradigm for long aspect ratio (LAR) CeO2 is also relevant in vivo, we performed comparative studies in the mouse lung and gastrointestinal tract (GIT) of zebrafish larvae. Although oropharyngeal aspiration could induce acute lung inflammation for CeO2 nanospheres and nanorods, only the nanorods with the highest AR (C5) induced significant IL-1β and TGF-β1 production in the bronchoalveolar lavage fluid (BALF) at 21 days but not inducing pulmonary fibrosis. However, after a longer duration (44 days) exposure to 4 mg/kg of the C5 nanorods, more collagen production was seen with CeO2 nanorods vs. nanospheres after correcting for Ce lung burden. Using an oral-exposure model in zebrafish larvae, we demonstrated that C5 nanorods also induced significant growth inhibition, a decrease in body weight, and delayed vertebral calcification. In contrast, CeO2 nanospheres and shorter nanorods had no effect. Histological and transmission electron microscopy (TEM) analyses showed that the key injury mechanism of C5 was in the epithelial lining of the GIT, which demonstrated blunted microvilli and compromised digestive function. All considered, these data demonstrate that, similar to cellular studies, LAR CeO2 nanorods exhibit more toxicity in the lung and GIT, which could be relevant to inhalation and environmental hazard potential. PMID:24720650

  20. Measurements of the cosmic-ray Be/B ratio and the age of cosmic rays

    NASA Technical Reports Server (NTRS)

    Brown, J. W.; Stone, E. C.; Vogt, R. E.

    1974-01-01

    The ratio Be/B depends on whether the confinement time of cosmic rays in the Galaxy is long or short compared to the radioactive half-life of Be-10. We report observations of this ratio which were obtained with a dE/dx-Cerenkov detector launched into a polar orbit on OGO-6 as part of the Caltech Solar and Galactic Cosmic Ray Experiment. Be/B ratios were determined for various rigidity thresholds up to 15 GV. We find no statistically significant rigidity dependence of the ratio, which is 0.41 plus or minus 0.02 when averaged over all observed cutoffs. Additional calculations suggest that if the present fragmentation parameters are correct, then the lifetime of cosmic rays in the Galaxy is less then 10 m.y.

  1. Age estimation from pulp/tooth area ratio in maxillary incisors among Egyptians using dental radiographic images.

    PubMed

    Zaher, Jaklin Fekri; Fawzy, Irene Atef; Habib, Sahar Refaat; Ali, Magdy Mohamed

    2011-02-01

    Age estimation from dental radiographs is a non-destructive, simple method to obtain information. The aim of this study was to determine the reliability of age estimation from Egyptians' incisors radiographs. 144 periapical radiographs of maxillary (central & lateral) incisors (both sexes) aged 12-60 were used. Digital camera was used to image the radiographs. Images were computed and pulp/tooth area ratios were determined by AutoCAD Program. Data were subjected to correlation and regression analysis which showed statistically significant correlation (r = 0.23 &P = 0.006 for maxillary central incisors and r = -0.2 &P = 0.05 for maxillary lateral incisors) between age and pulp tooth area ratio. Linear regression equations were determined separately for both central and lateral incisors along with the corresponding Standard Error of Estimate, which ranged from 1.2 to 5.08 years. Consequently, it was concluded that pulp/tooth area ratios of incisors are reliable for estimation of age among Egyptians in forensic work. PMID:21315299

  2. Does breeding population trajectory and age of nesting females influence disparate nestling sex ratios in two populations of Cooper's hawks?

    PubMed

    Rosenfield, Robert N; Stout, William E; Giovanni, Matthew D; Levine, Noah H; Cava, Jenna A; Hardin, Madeline G; Haynes, Taylor G

    2015-09-01

    Offspring sex ratios at the termination of parental care should theoretically be skewed toward the less expensive sex, which in most avian species would be females, the smaller gender. Among birds, however, raptors offer an unusual dynamic because they exhibit reversed size dimorphism with females being larger than males. And thus theory would predict a preponderance of male offspring. Results for raptors and birds in general have been varied although population-level estimates of sex ratios in avian offspring are generally at unity. Adaptive adjustment of sex ratios in avian offspring is difficult to predict perhaps in part due to a lack of life-history details and short-term investigations that cannot account for precision or repeatability of sex ratios across time. We conducted a novel comparative study of sex ratios in nestling Cooper's hawks (Accipiter cooperii) in two study populations across breeding generations during 11 years in Wisconsin, 2001-2011. One breeding population recently colonized metropolitan Milwaukee and exhibited rapidly increasing population growth, while the ex-Milwaukee breeding population was stable. Following life-history trade-off theory and our prediction regarding this socially monogamous species in which reversed sexual size dimorphism is extreme, first-time breeding one-year-old, second-year females in both study populations produced a preponderance of the smaller and cheaper sex, males, whereas ASY (after-second-year), ≥2-year-old females in Milwaukee produced a nestling sex ratio near unity and predictably therefore a greater proportion of females compared to ASY females in ex-Milwaukee who produced a preponderance of males. Adjustment of sex ratios in both study populations occurred at conception. Life histories and selective pressures related to breeding population trajectory in two age cohorts of nesting female Cooper's hawk likely vary, and it is possible that these differences influenced the sex ratios we documented for

  3. Does breeding population trajectory and age of nesting females influence disparate nestling sex ratios in two populations of Cooper's hawks?

    PubMed

    Rosenfield, Robert N; Stout, William E; Giovanni, Matthew D; Levine, Noah H; Cava, Jenna A; Hardin, Madeline G; Haynes, Taylor G

    2015-09-01

    Offspring sex ratios at the termination of parental care should theoretically be skewed toward the less expensive sex, which in most avian species would be females, the smaller gender. Among birds, however, raptors offer an unusual dynamic because they exhibit reversed size dimorphism with females being larger than males. And thus theory would predict a preponderance of male offspring. Results for raptors and birds in general have been varied although population-level estimates of sex ratios in avian offspring are generally at unity. Adaptive adjustment of sex ratios in avian offspring is difficult to predict perhaps in part due to a lack of life-history details and short-term investigations that cannot account for precision or repeatability of sex ratios across time. We conducted a novel comparative study of sex ratios in nestling Cooper's hawks (Accipiter cooperii) in two study populations across breeding generations during 11 years in Wisconsin, 2001-2011. One breeding population recently colonized metropolitan Milwaukee and exhibited rapidly increasing population growth, while the ex-Milwaukee breeding population was stable. Following life-history trade-off theory and our prediction regarding this socially monogamous species in which reversed sexual size dimorphism is extreme, first-time breeding one-year-old, second-year females in both study populations produced a preponderance of the smaller and cheaper sex, males, whereas ASY (after-second-year), ≥2-year-old females in Milwaukee produced a nestling sex ratio near unity and predictably therefore a greater proportion of females compared to ASY females in ex-Milwaukee who produced a preponderance of males. Adjustment of sex ratios in both study populations occurred at conception. Life histories and selective pressures related to breeding population trajectory in two age cohorts of nesting female Cooper's hawk likely vary, and it is possible that these differences influenced the sex ratios we documented for

  4. Precision and reliability of pulp/tooth area ratio (RA) of second molar as indicator of adult age.

    PubMed

    Cameriere, Roberto; Ferrante, Luigi; Cingolani, Mariano

    2004-11-01

    This paper discusses a method for assessing adult age based on the relationship between age and measurement of the pulp/tooth area ratio (RA) of the second molar teeth. The sample consisted of 312 Italian white Caucasian patients (135 men, 177 women) aged between 14 and 24 years. Orthopantomograph samples (OPGs) were analyzed by the same observer and calibrated by kappa statistics. Probabilities of an individual being older than 18 years of age (adult age) were derived using measurements of the ratio pulp/tooth area (RA) of the second molar teeth and the dichotomized stages of third molar development (Tm) as explanatory variables. These results were exploited to establish a threshold value to assign an individual to juvenile or adult age. A cut-off value of RA* = 0.088 was applied if Tm = 0 and RA* = 0.097 if Tm = 1. The sensitivity of this test was 91% and its specificity 94.5%. The proportion of individuals with correct classifications was 92%.

  5. The second to fourth digit ratio and age at first marriage in semi-nomadic people from Namibia.

    PubMed

    Sorokowski, Piotr; Sorokowska, Agnieszka; Danel, Dariusz; Mberira, Mara L; Pokrywka, Leszek

    2012-06-01

    The second to fourth digit ratio (2D:4D) is used as a potential marker for prenatal androgen exposure. It is associated with many behavioral and biological variables, including fertility and sexual behavior. However, direct association between 2D:4D and reproductive success--in populations where no contraceptives are used--has not been investigated. Here, we present a study conducted among the semi-nomad Himba population living in northern Namibia. 2D:4D ratios were calculated for a sample of this population (N=99; 60 women, 39 men), and the results were correlated with age, marital status, age at first marriage, number of children, and number of marriages. As found in the majority of previous studies, males had lower 2D:4D ratios than females. The 2D:4D ratio did not correlate with number of children. Females and males with a more masculine 2D:4D were married earlier and were more likely to have a husband or wife. We suggest that mating preferences for females with masculine 2D:4D are related to masculinity of phenotypic and personality traits of such women, which are beneficial in harsh environmental conditions and/or higher facial masculinity, which influences the perceived age of an individual. At the same time, masculine (physically strong, dominant, and hardworking) males might gather resources necessary to marry their first wife earlier.

  6. META-ANALYSIS OF THE LIFE STYLE FACTORS RELEVANT TO ENVIRONMENTAL HAZARDS FOR THE AGING POPULATION

    EPA Science Inventory

    The goal of this U.S. Environmental Protection Agency (EPA) study is to characterize activity patterns, physiological changes, and environmental exposures for the aging population. Meta analysis was performed on more than 2000 reviewed articles to evaluate the lifestyle factors ...

  7. The face-time continuum: lifespan changes in facial width-to-height ratio impact aging-associated perceptions.

    PubMed

    Hehman, Eric; Leitner, Jordan B; Freeman, Jonathan B

    2014-12-01

    Aging influences how a person is perceived on multiple dimensions (e.g., physical power). Here we examined how facial structure informs these evolving social perceptions. Recent work examining young adults' faces has revealed the impact of the facial width-to-height ratio (fWHR) on perceived traits, such that individuals with taller, thinner faces are perceived to be less aggressive, less physically powerful, and friendlier. These perceptions are similar to those stereotypically associated with older adults. Examining whether fWHR might contribute to these changing perceptions over the life span, we found that age provides a shifting context through which fWHR differentially impacts aging-related social perceptions (Study 1). In addition, archival analyses (Study 2) established that fWHR decreases across age, and a subsequent study found that fWHR mediated the relationship between target age and multiple aging-related perceptions (Study 3). The findings provide evidence that fWHR decreases across age and influences stereotypical perceptions that change with age. PMID:25278108

  8. Associations of age with serum insulin, proinsulin and the proinsulin-to-insulin ratio: a cross-sectional study

    PubMed Central

    2010-01-01

    Background Insulin responses and insulin levels seem to decline with age. However, the question of beta cell impairment attributable to ageing has been sparsely addressed in population-based studies. Non-fasting insulin levels are determined by the ambient degree of insulin resistance together with the capacity of beta cells to compensate by insulin secretion to prevent hyperglycaemia. A raised proinsulin-to-insulin ratio (proinsulin/insulin) due to impaired processing of proinsulin is an early marker of beta cell dysfunction. We hypothesised that in a general population, signs of beta cell failure with advancing age manifest not only by decreases in random insulin, but also with a corresponding increase in its precursor proinsulin. Methods In the Tromsø Study 1994-95 we measured insulin and proinsulin concentrations in random blood samples from 6212 persons without self-reported diabetes mellitus and plotted the levels as percentiles according to age. In regression analyses we assessed the relationships between age and insulin, proinsulin, and proinsulin/insulin, while adjusting for the concomitant measurements of glucose and other metabolic variables, and the time since the last meal. Results Median insulin concentrations declined significantly with advancing age group in men, but not in women. Proinsulin levels and proinsulin/insulin increased across age groups in both genders. After adjustment, greater age was associated with lower log10(insulin) and higher log10(proinsulin) and log10(proinsulin/insulin) (p = 0.0001 for all). Conclusions Negative associations of age with random insulin levels, together with positive associations of age with proinsulin and proinsulin/insulin, point towards a loss of beta cell function inherent in the ageing process. PMID:21162746

  9. The relationship between paternal age, sex ratios, and aneuploidy frequencies in human sperm, as assessed by multicolor FISH

    SciTech Connect

    Martin, R.H.; Spriggs, E. |; Ko, E.

    1995-12-01

    We studied the frequencies of X- and Y-chromosome bearing sperm, diploidy and disomy for chromosomes 1, 12, X, and Y in sperm from 10 normal men aged 21 - 52 years, to determine whether there was any relationship between donor age and any of these variables. Multicolor FISH was used to control for lack of probe hybridization and to distinguish diploid sperm from disomic sperm. A minimum of 10,000 sperm per donor was evaluated for each chromosome, for a total of 225,846 sperm studied. Sperm were considered disomic if two fluorescent signals were separated by a minimal distance of one signal domain. The mean frequencies of X- and Y-bearing sperm were 50.1% and 49.0%, respectively; not significantly different from 50%. There was no correlation between paternal age and {open_quotes}sex ratio {close_quotes} in sperm. Similarly, there was no association between the frequency of diploid sperm (mean, .16%; range, .06%-.42%) and donor age. For disomy frequencies, there was no relationship between donor age and disomy 12 (mean, .16%; range, .10%-.25%), XX (mean, .07%; range, .03%-.17%), and XY sperm (mean, .16%; range, .08%-.24%). There was a significant increase in the frequency of YY sperm (P = .04; mean, .18%; range, .10%-.43%) and disomy 1 sperm (P = .01; mean, .11%; range, .05%-.18%) with donor age. In summary, our results do not support a correlation between paternal age and sex ratio or diploidy. A relationship between paternal age and disomy was observed for disomy 1 and YY sperm but not for disomy 12, XX or XY sperm. 37 refs., 3 tabs.

  10. The age of illite cement growth, Village Fields area, Southern North Sea: Evidence from K-Ar ages and [sup 18]O/[sup 16]O ratios

    SciTech Connect

    Robinson, A.G.; Coleman, M.L.; Gluyas, J.G. )

    1993-01-01

    In this paper we describe K-Ar radiometric ages and oxygen isotope ratio measurements of illite cements from eolian sandstone samples of the Permian lower Leman Sandstone Formation (Rotliegen-des Group). The samples come from a large (about 100 [times] 100 km) part of the Southern North Sea basin (Village Fields area) and from a range of burial depths (2.8-3.4 km subsea bed). Mean illite ages in the gas fields of Ravenspuran North (164 Ma [+-] 20.1 [2[sigma

  11. Age estimation by pulp/tooth area ratio in canines: study of a Portuguese sample to test Cameriere's method.

    PubMed

    Cameriere, R; Cunha, E; Sassaroli, E; Nuzzolese, E; Ferrante, L

    2009-12-15

    Age estimation in adults is an important problem in both anthropological and forensic fields, and apposition of secondary dentine is often used as an indicator of age. In recent papers, Cameriere et al. studied the pulp/tooth area ratio of canines for this purpose. The present study examines the application of the pulp/tooth area ratio by peri-apical X-ray images as an age indicator in a Portuguese identified sample. The statistical model was then compared with results from an Italian identified sample, to establish whether a common regression model for both samples could be developed. The Portuguese sample consisted of 126 canines of male and 132 of female from subjects 20 to 84 years old, from the osteological collection of the Museum of Anthropology at Coimbra University. The Italian sample consisted of 114 canines of male and 86 of female from subjects 20 to 79 years old, analyzed in Cameriere et al. (2007), and came from the Frassetto osteological collection of Sassari (Sardinia), now housed in the Museum of Anthropology, Department of Experimental and Evolutionistic Biology, University of Bologna. Statistical analysis was performed in order to obtain multiple regression formulas for dental age calculation, with chronological age as dependent variable, and gender and pulp/tooth area ratio on upper (RA(u)) and lower canines (RA(l)) as independent variables. ANCOVA analysis showed that gender was not significant but that variables RA(u) and RA(l) were. The regression model for the Portuguese sample yielded the following equations: Age=101.3-556.68 RA(u) (upper canines) and Age=92.37-492.05 RA(l) (lower canines). Both models explained about 97% of total variance, and mean prediction errors were ME=2.37 years and 2.55 years, respectively. Comparisons between the equation referring to the Portuguese sample and the equivalent linear equations proposed by Cameriere et al. for the Italian sample did not reveal significant differences between the linear models

  12. Age estimation by pulp/tooth ratio in lateral and central incisors by peri-apical X-ray.

    PubMed

    Cameriere, R; Cunha, E; Wasterlain, S N; De Luca, S; Sassaroli, E; Pagliara, F; Nuzzolese, E; Cingolani, M; Ferrante, L

    2013-07-01

    Since 2004, several papers on the analysis of the apposition of secondary dentine have been published. The aim of this paper was to study a sample of peri-apical X-ray images of upper and lower incisors, both lateral and medial, to examine the application of pulp/tooth area ratio as an indicator of age. A sample of 116 individuals, 62 men and 54 women, aged between 18 and 74 years, was studied. Data were fitted with age as a linear function of the pulp/tooth ratio of incisors. The total variance explained by the regression equation ranged from 51.3% of age, when lower lateral incisors were used as explanatory variable, to 81.6% when upper lateral incisors were used. The accuracy of the corresponding regression model yielded ME = 8.44 and 5.34 years, respectively. These results show that, although incisors are less reliable than canines or lower premolars, they can be used to estimate age-at-death when the latter are absent.

  13. Age at sexual maturity, sex ratio, fecundity, and longevity of isolated headwater populations of Westslope cutthroat trout

    USGS Publications Warehouse

    Downs, Christopher C.; White, R.G.; Shepard, B.B.

    1997-01-01

    We sampled 19 isolated headwater populations of westslope cutthroat trout Oncorhynchus clarki lewisi in Montana to provide estimates of fecundity, longevity, sex ratio, and age at sexual maturity. Fecundity was estimated for 31 fish collected from two streams in the upper Missouri River drainage. Females smaller than 149 mm fork length (FL) were generally immature and their fecundities could not be estimated. Mean fecundities (SD) were 227 eggs (41.1) for 150-174-mm fish, 346 eggs (85.6) for 175-199-mm fish, and 459 eggs (150.8) for 200-mm and larger fish. A linear regression model (two stream samples combined) to predict fecundity (E) from fork length was developed (E = -494.9 + 4.4.FL: r2 = 0.51, P < 0.001) for westslope cutthroat trout in the upper Missouri River drainage. Regression slopes of fecundity against fish length differed significantly (P < 0.01) between these and some of the previously studied populations. Steeper slopes were associated with lacustrine-adfluvial populations. The average sex ratio was 1.3 males per female across all sampled streams. Males began to mature sexually at age 2 and all were mature by age 4. Some females (27%) were sexually mature at age 3 and most of them (93%) were mature by age 5. Length was a better predictor of sexual maturity than age. Males matured at 110-160 mm and females at 150-180 mm FL. The maximum estimated age was 8 years based on otoliths from 475 fish collected from our 19 study streams and 14 additional streams.

  14. Age estimation by pulp/tooth ratio in canines by mesial and vestibular peri-apical X-rays.

    PubMed

    Cameriere, Roberto; Ferrante, Luigi; Belcastro, Maria Giovanna; Bonfiglioli, Benedetta; Rastelli, Elisa; Cingolani, Mariano

    2007-09-01

    Changes in the size of the pulp canal, caused by apposition of secondary dentine, are the best morphometric parameters for estimating age by X-rays. The apposition of secondary dentine is the most frequently used method for age estimation in adult subjects. In two previous papers, we studied the application of the pulp/tooth area ratio by peri-apical X-rays as an indicator of age at death. The aim of the present study was to test the accuracy of age evaluation by combined analysis of labio-lingual and mesial peri-apical X-rays of lower and upper canines. A total of 200 such X-rays were assembled from 57 male and 43 female skeletons of Caucasian origin, aged between 20 and 79 years. For each skeleton, dental maturity was evaluated by measuring the pulp/tooth area ratio according to labio-lingual and mesial X-rays on upper (x(1), x(2)) and lower (x(3), x(4)) canines. Very good agreement was found between intra-observer measurements. Statistical analysis showed that all variables x(1), x(2), x(3), and x(4) and the first-order interaction between x(1) and x(3) contributed significantly to the fit, so that they were included in the regression model, yielding the following regression formula: Age = 120.737 - 337.112x(1) - 79.709x(2) - 364.534x(3) - 65.655x(4) + 1531.918x(1)x(3) . The residual standard error of estimated ages was 3.62 years, with 94 degrees of freedom, and the median of the residuals was -0.155 years, with an interquartile range of 4.96 years. The accuracy of the method was ME = 2.8 years, where ME is the mean prediction error. The model also explained 94% of total variance (R(2) = 0.94).

  15. Influence of chemical oxygen demand/total Kjeldahl nitrogen ratio and sludge age on nitrification of nitrogenous wastewater.

    PubMed

    Sharma, R; Gupta, S K

    2004-01-01

    Four laboratory-scale biological nitrification units (influent total Kjeldahl nitrogen [TKN] = 1002 to 1062 mg/L) were operated at chemical oxygen demand (COD)/TKN ratios of approximately 0.5, 1.0,15, and 2.0 and at three different sludge ages of 30, 20, and 10 days to study the influence of COD/TKN, sludge age, COD loading, and TKN loading on nitrification and nitrifiers. Percent nitrification was found to increase with decreases in COD/TKN and increases in sludge age. The average nitrifier concentration increased from 460 mg/L at a COD/TKN of 2.22 and a sludge age of 10 days to 706 mg/L at a COD/TKN of 0.676 and a sludge age of 30 days. The nitrifier fraction was found to be higher at a lower COD/TKN and lower at a higher COD/TKN. The nitrifier fraction increased with the decrease in sludge age and COD loadings and the increase in TKN loadings. The effect of sludge age on the nitrifier fraction was amplified at a COD/ TKN of approximately 0.5 rather than at approximately 2.0. The nitrification rate (kilograms TKN oxidized per kilograms nitrifiers per day) was shown to be dependent on COD/TKN and sludge age. The activity performed by Nitrobacter was affected at all COD/TKN ratios studied as well as at a sludge age of 10 days. This was manifested by the accumulation of high levels of nitrite-nitrogen in the nitrified effluent. The presence of heterotrophs did not affect nitrification rates and the growth of nitrifiers, which were found to be beneficial. High sludge age and COD loadings resulted in a higher sludge volume index of more than 200 mL/g mixed liquor suspended solids. Microscopic examination showed filamentous structure of sludge under these conditions. It is concluded from the investigations that a sludge age of 30 days and a COD/TKN of approximately 1.0 are optimal to yield maximum nitrification and nitrifier growth rates for treating high-strength nitrogenous wastewater.

  16. Increased Waist-to-height Ratio May Contribute to Age-related Increase in Cardiovascular Risk Factors

    PubMed Central

    Akhlaghi, Masoumeh; Kamali, Majid; Dastsouz, Farideh; Sadeghi, Fatemeh; Amanat, Sassan

    2016-01-01

    Background: The risk of cardiovascular diseases (CVDs) increases with age. The objective was to determine whether lifestyle and dietary behaviors and anthropometric measures, which are affected by these behaviors, contribute to the increase of CVD risk factors across age categories of 20–50-year-old. Methods: In a cross-sectional design, 437 adults aged 20–50-year-old were selected from households living in Shiraz. Risk factors of CVD, including body mass index (BMI), waist-to-height ratio (WHtR), blood pressure, fasting blood glucose (FBG), serum triglycerides, total cholesterol, and low- and high-density lipoprotein cholesterol (LDL-C and HDL-C, respectively) as well as lifestyle behaviors (physical activity and smoking), dietary habits, and food intakes were assessed across the age categories of 20–29, 30–39, and 40–50 years. Linear regression was used to examine the contribution of different variables to the age-related increase of CVD risk factors. Results: All CVD risk factors, except for HDL-C, significantly increased across age categories. Older subjects had healthier dietary habits and food intakes, but they possessed nonsignificantly lower physical activity and higher smoking rate compared to younger adults. Adjusting for physical activity, smoking, and BMI did not change the significant positive association between age and CVD risk factors but adjusting for WHtR disappeared associations for blood pressure, triglycerides, and metabolic syndrome although significant associations remained for FBG and total and LDL-C. Conclusions: Age-related increase of CVD risk factors occurred independent of lifestyle habits. WHtR, but not BMI, may partially contribute to the age-related increase in CVD risk factors. PMID:27195100

  17. The dissimilar costs of love and war: age-specific mortality as a function of the operational sex ratio.

    PubMed

    Adler, M I; Bonduriansky, R

    2011-06-01

    Lifespan and ageing are strongly affected by many environmental factors, but the effects of social environment on these life-history traits are not well understood. We examined effects of social interaction on age-specific mortality rate in the sexually dimorphic neriid fly Telostylinus angusticollis. We found that although interaction with other individuals reduced longevity of both sexes, the costs associated with variation in operational sex ratio were sex specific: males' early-life mortality rate increased, and lifespan decreased, with increasing male bias in the sex ratio, whereas surprisingly, the presence of males had no effect on early-life mortality or lifespan of females. Intriguingly, early-life (immediate) mortality costs did not covary with late-life (latent) costs. Rather, both sexes aged most rapidly in a social environment dominated by the opposite sex. Our findings suggest that distinct reproductive activities, such as mating and fighting, impose different age-specific patterns of mortality, and that such costs are strongly sex specific.

  18. High-precision abundances of Sc, Mn, Cu, and Ba in solar twins. Trends of element ratios with stellar age

    NASA Astrophysics Data System (ADS)

    Nissen, P. E.

    2016-09-01

    Aims: A previous study of correlations between element abundances and ages of solar twin stars in the solar neighborhood is extended to include Sc, Mn, Cu, and Ba to obtain new information on the nucleosynthetic history of these elements. Methods: HARPS spectra with S/N ≳ 600 are used to derive very precise (σ ~ 0.01 dex) differential abundances of Sc, Mn, Cu, and Ba for 21 solar twins and the Sun. The analysis is based on MARCS model atmospheres with parameters determined from the excitation and ionization balance of Fe lines. Stellar ages with internal errors less than 1 Gyr are obtained by interpolation in the log g - Teff diagram between isochrones based on the Aarhus Stellar Evolution Code. Results: For stars younger than 6 Gyr, [Sc/Fe], [Mn/Fe], [Cu/Fe], and [Ba/Fe] are tightly correlated with stellar age, which is also the case for the other elements previously studied; linear relations between [X/Fe] and age have χ^2red ˜ 1, and for most stars the residuals do not depend on elemental condensation temperature. For ages between 6 and 9 Gyr, the [X/Fe] - age correlations break down and the stars split up into two groups having respectively high and low [X/Fe] for the odd-Z elements Na, Al, Sc, and Cu. Conclusions: While stars in the solar neighborhood younger than ~ 6 Gyr were formed from interstellar gas with a smooth chemical evolution, older stars seem to have originated from regions enriched by supernovae with different neutron excesses. Correlations between abundance ratios and stellar age suggest that: (i) Sc is made in Type II supernovae along with the α-capture elements; (ii) the Type II to Ia yield ratio is about the same for Mn and Fe; (iii) Cu is mainly made by the weak s-process in massive stars; (iv) the Ba/Y yield ratio for asymptotic giant branch stars increases with decreasing stellar mass; (v) [Y/Mg] and [Y/Al] can be used as chemical clocks when determining ages of solar metallicity stars. Based on data products from observations made

  19. The significance of placental ratios in pregnancies complicated by small for gestational age, preeclampsia, and gestational diabetes mellitus

    PubMed Central

    Kim, Hee Sun; Cho, Soo Hyun; Kwon, Han Sung; Sohn, In Sook

    2014-01-01

    Objective This study aimed to evaluate the placental weight, volume, and density, and investigate the significance of placental ratios in pregnancies complicated by small for gestational age (SGA), preeclampsia (PE), and gestational diabetes mellitus (GDM). Methods Two hundred and fifty-four pregnant women were enrolled from August 2005 through July 2013. Participants were divided into four groups: control (n=82), SGA (n=37), PE (n=102), and GDM (n=33). The PE group was classified as PE without intrauterine growth restriction (n=65) and PE with intrauterine growth restriction (n=37). Birth weight, placental weight, placental volume, placental density, and placental ratios including birth weight/placental weight ratio (BPW) and birth weight/placental volume ratio (BPV) were compared between groups. Results Birth weight, placental weight, and placental volume were lower in the SGA group than in the control group. However, the BPW and BPV did not differ between the two groups. Birth weight, placental weight, placental volume, BPW, and BPV were all significantly lower in the PE group than in the control group. Compared with the control group, birth weight, BPW, and BPV were higher in the GDM group, whereas placental weight and volume did not differ in the two groups. Placental density was not significantly different among the four groups. Conclusion Placental ratios based on placental weight, placental volume, placental density, and birth weight are helpful in understanding the pathophysiology of complicated pregnancies. Moreover, they can be used as predictors of pregnancy complications. PMID:25264525

  20. Growth and haematological response of indigenous Venda chickens aged 8 to 13 weeks to varying dietary lysine to energy ratios.

    PubMed

    Alabi, O J; Ng'ambi, J W; Mbajiorgu, E F; Norris, D; Mabelebele, M

    2015-06-01

    The effect of feeding varying dietary lysine to energy levels on growth and haematological values of indigenous Venda chickens aged 8 - 13 weeks was evaluated. Four hundred and twenty Venda chickens (BW 362 ± 10 g) were allocated to four dietary treatments in a completely randomized design. Each treatment was replicated seven times, and each replicate had fifteen chickens. Four maize-soya beans-based diets were formulated. Each diet had similar CP (150 g/kg DM) and lysine (8 g lysine/kg DM) but varying energy levels (11, 12, 13 and 14 MJ ME/kg DM). The birds were reared in a deep litter house; feed and water were provided ad libitum. Data on growth and haematological values were collected and analysed using one-way analysis of variance. Duncan's test for multiple comparisons was used to test the significant difference between treatment means (p < 0.05). A quadratic equation was used to determine dietary lysine to energy ratios for optimum parameters which were significant difference. Results showed that dietary energy level influenced (p < 0.05) feed intake, feed conversion ratio, live weight, haemoglobin and pack cell volume values of chickens. Dry matter digestibility, metabolizable energy and nitrogen retention not influenced by dietary lysine to energy ratio. Also, white blood cell, red blood cell, mean corpuscular volume, mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration in female Venda chickens aged 91 days were not influenced by dietary lysine to energy ratio. It is concluded that dietary lysine to energy ratios of 0.672, 0.646, 0.639 and 0.649 optimized feed intake, growth rate, FCR and live weight in indigenous female Venda chickens fed diets containing 8 g of lysine/kg DM, 150 g of CP/kg DM and 11 MJ of ME/kg DM. This has implications in diet formulation for indigenous female Venda chickens.

  1. The U/Th production ratio and the age of the Milky Way from meteorites and Galactic halo stars.

    PubMed

    Dauphas, Nicolas

    2005-06-30

    Some heavy elements (with atomic number A > 69) are produced by the 'rapid' (r)-process of nucleosynthesis, where lighter elements are bombarded with a massive flux of neutrons. Although this is characteristic of supernovae and neutron star mergers, uncertainties in where the r-process occurs persist because stellar models are too crude to allow precise quantification of this phenomenon. As a result, there are many uncertainties and assumptions in the models used to calculate the production ratios of actinides (like uranium-238 and thorium-232). Current estimates of the U/Th production ratio range from approximately 0.4 to 0.7. Here I show that the U/Th abundance ratio in meteorites can be used, in conjunction with observations of low-metallicity stars in the halo of the Milky Way, to determine the U/Th production ratio very precisely (0.57(+0.037)(-0.031). This value can be used in future studies to constrain the possible nuclear mass formulae used in r-process calculations, to help determine the source of Galactic cosmic rays, and to date circumstellar grains. I also estimate the age of the Milky Way (14.5(+2.8)(-2.2)Gyr in a way that is independent of the uncertainties associated with fluctuations in the microwave background or models of stellar evolution.

  2. Beryllium geochemistry in soils: Evaluation of 10Be/9Be ratios in authigenic minerals as a basis for age models

    USGS Publications Warehouse

    Barg, E.; Lal, D.; Pavich, M.J.; Caffee, M.W.; Southon, J.R.

    1997-01-01

    Soils contain a diverse and complex set of chemicals and minerals. Being an 'open system', both in the chemical and nuclear sense, soils have defied quantitative nuclear dating. However, based on the published studies of the cosmogenic atmospheric 10Be in soils, its relatively long half-life (1.5 Ma), and the fact that 10Be gets quickly incorporated in most soil minerals, this radionuclide appears to be potentially the most useful for soil dating. We therefore studied the natural variations in the specific activities of 10Be with respect to the isotope 9Be in mineral phases in eight profiles of diverse soils from temperate to tropical climatic regimes and evaluated the implications of the data for determining the time of formation of soil minerals, following an earlier suggestion [Lal et al., 1991. Development of cosmogenic nuclear methods for the study of soil erosion and formation rates. Current Sci. 61, 636-639.]. We find that the 10Be/9Be ratios in both bulk soils and in the authigenic mineral phases are confined within a narrower range than in 10Be concentrations. Also, the highest 10Be/9Be ratios in authigenic minerals are observed at the soil-rock interface as predicted by the model. We present model 10Be/9Be ages of the B-horizon and the corresponding soil formation rates for several soil profiles. The present study demonstrates that the 10Be/9Be ratios in the authigenic phases, e.g. clay and Fe-hydroxides, can indeed be used for obtaining useful model ages for soils younger than 10-15 Ma. However, the present work has to be pushed considerably further, to take into account more realistic age models in which, for instance, downward transport of 10Be and clays, and in-situ dissolution of clay minerals at depths, altering the 10Be/9Be ratios of the acidic solutions, are included. We show that in the case of younger soils (< 1 Ma) studied here, their 10Be inventories and 10Be/9Be ratios have been significantly disturbed possibly by mixing with transported

  3. Growth, age at metamorphosis, and sex ratio of northern brook lamprey in a tributary of southern Lake Superior

    USGS Publications Warehouse

    Purvis, Harold A.

    1970-01-01

    Growth was studied of five year classes of the northern brook lamprey, Ichthyomyzon fossor, collected from the Sturgeon River during intervals between treatment of the stream with a lampricide. Growth varied considerably among year classes. Larvae of the 1963 year class were slightly longer at age II and 30% longer at age III than the III-group larvae of the 1960 year class. About 6% of 558 III-group lampreys of the 1963 year class had metamorphosed by 17 August 1966. Although the sex ratio of larvae was about 1:1, 97% of the metamorphosed lampreys were males. The distribution of pigmentation on the caudal fin and upper lip in ammocoetes less than 40 mm long permitted accurate and rapid separation of northern brook lampreys from the sea lamprey, Petromyzon marinus.

  4. Effect of Maternal Age on the Ratio of Cleavage and Mitochondrial DNA Copy Number in Early Developmental Stage Bovine Embryos

    PubMed Central

    TAKEO, Shun; GOTO, Hiroya; KUWAYAMA, Takehito; MONJI, Yasunori; IWATA, Hisataka

    2012-01-01

    Abstract Age-associated deterioration in both the quality and quantity of mitochondria occurs in older women. The main aim of this study was to examine the effect of age on mitochondrial DNA copy number (mtDNA number) in early developmental stage bovine embryos as well as the dynamics of mtDNA number during early embryo development. Real-time PCR was used to determine mtDNA number. In vitro-produced embryos 48 h after insemination derived from Japanese black cows, ranging in age from 25 to 209 months were categorized based on their cleavage status. There was an overall negative relationship between the age of the cow and cleavage status, to the extent that the ratio of embryos cleaved over the 4-cell stage was greater in younger cows. The mtDNA number did not differ among the cleaved status of embryos. In the next experiment, oocytes collected from each donor cow were divided into 2 groups containing 10 oocytes each, in order to compare the mtDNA number of mature oocytes and early developmental stage embryos within individuals. Upon comparing the mtDNA number between oocytes at the M2 stage and early developmental stage 48 h post insemination, mtDNA number was found to decrease in most cows, but was found to increase in some cows. In conclusion, age affects the cleaving ability of oocytes, and very old cows (> 180 months) tend to have lower mtDNA numbers in their oocytes. The change in mtDNA number during early development varied among individual cows, although overall, it showed a tendency to decrease. PMID:23269452

  5. Human dental age estimation by calculation of pulp-tooth volume ratios yielded on clinically acquired cone beam computed tomography images of monoradicular teeth.

    PubMed

    Star, Hazha; Thevissen, Patrick; Jacobs, Reinhilde; Fieuws, Steffen; Solheim, Tore; Willems, Guy

    2011-01-01

    Secondary dentine is responsible for a decrease in the volume of the dental pulp cavity with aging. The aim of this study is to evaluate a human dental age estimation method based on the ratio between the volume of the pulp and the volume of its corresponding tooth, calculated on clinically taken cone beam computed tomography (CBCT) images from monoradicular teeth. On the 3D images of 111 clinically obtained CBCT images (Scanora(®) 3D dental cone beam unit) of 57 female and 54 male patients ranging in age between 10 and 65 years, the pulp-tooth volume ratio of 64 incisors, 32 canines, and 15 premolars was calculated with Simplant(®) Pro software. A linear regression model was fit with age as dependent variable and ratio as predictor, allowing for interactions of specific gender or tooth type. The obtained pulp-tooth volume ratios were the strongest related to age on incisors.

  6. Accurate age scale of the Dome Fuji ice core, Antarctica from O2/N2 ratio of trapped air

    NASA Astrophysics Data System (ADS)

    Kawamura, K.; Aoki, S.; Nakazawa, T.; Suzuki, K.; Parrenin, F.

    2012-04-01

    Chronology of the first Dome Fuji deep ice core (core length: 2,500 m, ice thickness: 3,035 m) for the age range from 80 kyr to 340 kyr ago was established by orbital tuning of measured O2/N2 ratios in trapped air to local summer insolation, with precision better than about 2,000 years (Kawamura et al., 2007). The O2/N2 ratios found in polar ice cores are slightly lower than the atmospheric ratio because of size-dependent molecular fractionation during bubble close-off. The magnitude of this gas fractionation is believed to be governed by the magnitude of snow metamorphism when the layer was originally at the surface, which in turn is controlled by local summer insolation (Fujita et al., 2009). A strong advantage of the O2/N2 chronology is that there is no need to assume a lag between climatic records in the ice core and orbital forcings, becacuse O2/N2 ratios record local insolation through physical processes. Accuracy of the chronology was validated by comparing the O2/N2 chronology with U-Th radiometric chronology of speleothem records (Cheng et al., 2009) for the ends of Terminations II, III and IV, as well as several large climatic events, for which both ice-core CH4 and speleothem δ18O (a proxy for precipitation) show abrupt shifts as seen in the last glacial period. All ages from O2/N2 and U-Th chronology agreed with each other within ~2,000 yr. The O2/N2 chronology permits comparisons between Antarctic climate, greenhouse gases, astronomically calculated orbital parameters, and radiometrically-dated sea level and monsoon records. Here, we completed the measurements of O2/N2 ratios of the second Dome Fuji ice core, which reached bedrock, for the range from 2,400 to 3,028 m (320 - 700 kyr ago) at approximately 2,000-year time resolution. We made significant improvements in ice core storage practices and mass spectrometry. In particular, the ice core samples were stored at about -50 ° C until the air extraction, except during short periods of transportation

  7. Underestimation of urinary biomarker-to-creatinine ratio resulting from age-related gain in muscle mass in rats.

    PubMed

    Tonomura, Yutaka; Morikawa, Yuji; Takagi, Shingo; Torii, Mikinori; Matsubara, Mitsunobu

    2013-01-01

    Recent efforts have been made to identify useful urinary biomarkers of nephrotoxicity. Furthermore, the application of urine to the other toxicities as new biomarker source has been recently expanded. Meanwhile, correction of urinary biomarker concentrations according to fluctuations in urine flow rate is required for adequate interpretation of the alteration. The urinary biomarker-to-creatinine ratio (UBCR) is widely used because of the convenience, while the urinary biomarker-excretion rate is regarded as the gold standard corrective method. Because creatinine is a catabolite in energy production in muscles, we hypothesized that altered muscle mass could affect creatinine kinetics, ultimately affecting UBCR. However, no study has examined this hypothesis. In this study, we examined the influence of muscle mass gain on UBCR, using male Sprague-Dawley rats during the growth phase, 6-12-week old. Both plasma creatinine and excretion of urinary creatinine (Ucr excretion) showed increases with muscle mass gain in rats, in which the alterations of UBCR were lowered. The renal mRNA level of the organic cation transporter-2 (Oct2), a creatinine transporter, showed an age-related increase, whereas the mRNA level of multidrug and toxin extrusions-1 (Mate1) remained constant. Multiple regression analysis showed that the increase in creatinine clearance highly contributed to the age-related increase in Ucr excretion compared to the mRNA levels of Oct2 and Mate1. This suggested that the age-related increase in Ucr excretion may be attributable to the increased transglomerular passage of creatinine. In conclusion, the results suggest that muscle mass gain can affect creatinine kinetics, leading to underestimation of UBCR. Therefore, it is important to understand the characteristics of the corrective method when using urinary biomarker, the failure of which can result in an incorrect diagnosis.

  8. Age estimation in an Indian population using pulp/tooth volume ratio of mandibular canines obtained from cone beam computed tomography.

    PubMed

    Jagannathan, N; Neelakantan, P; Thiruvengadam, C; Ramani, P; Premkumar, P; Natesan, A; Herald, J S; Luder, H U

    2011-07-01

    The present study assessed the suitability of pulp/tooth volume ratio of mandibular canines for age prediction in an Indian population. Volumetric reconstruction of scanned images of mandibular canines from 140 individuals (aged ten - 70 years), using computed tomography was used to measure pulp and tooth volumes. Age calculated using a formula reported earlier for a Belgian sample, resulted in errors > ten years in almost 86% of the study population. The regression equation obtained for the Indian population: Age = 57.18 + (- 413.41 x pulp/tooth volume ratio), was applied to an independent control group (n = 48), and this resulted in mean absolute errors of 8.54 years which was significantly (p < 0.05) lower than those derived with the Belgian formula. The pulp/tooth volume ratio is a useful indicator of age, although correlations may vary in different populations and hence, specific formulae should be applied for the estimates. PMID:21841263

  9. The Relationship between the Second-to-Fourth Digit Ratio and Behavioral Sexual Dimorphism in School-Aged Children

    PubMed Central

    Mitsui, Takahiko; Araki, Atsuko; Miyashita, Chihiro; Ito, Sachiko; Ikeno, Tamiko; Sasaki, Seiko; Kitta, Takeya; Moriya, Kimihiko; Cho, Kazutoshi; Morioka, Keita; Kishi, Reiko; Shinohara, Nobuo; Takeda, Masayuki; Nonomura, Katsuya

    2016-01-01

    Sexually dimorphic brain development and behavior are known to be influenced by sex hormones exposure in prenatal periods. On the other hand, second-to forth digit ratio (2D/4D) has been used as an indirect method to investigate the putative effects of prenatal exposure to androgen. In the present study, we herein investigated the relationship between gender-role play behavior and the second-to-fourth digit ratio (2D/4D), which has been used as an indirect method to investigate the putative effects of prenatal exposure to androgens, in school-aged children. Among 4981 children who became 8 years old by November 2014 and were contactable for this survey by The Hokkaido Study of Environment and Children's Health, 1631 (32.7%), who had data for 2D/4D and Pre-school Activities Inventory (PSAI) as well as data for the survey at baseline, were available for analysis. Parents sent reports of PSAI on the sex-typical characteristics, preferred toys, and play activities of children, and black and white photocopies of the left and right hand palms via mail. PSAI consisted of 12 masculine items and 12 feminine items, and a composite score was created by subtracting the feminine score from the masculine score, with higher scores representing masculine-typical behavior. While composite scores in PSAI were significantly higher in boys than in girls, 2D/4D was significantly lower in boys than in girls. Although the presence or absence of brothers or sisters affected the composite, masculine, and feminine scored of PSAI, a multivariate regression model revealed that 2D/4D negatively correlated with the composite scores of PSAI in boys, whereas no correlation was found in girls. Although 2D/4D negatively correlated with the masculine score in boys and girls, no correlation was observed between 2D/4D and the feminine score. In conclusion, although social factors, such as the existence of brother or sisters, affect dimorphic brain development and behavior in childhood, the present

  10. The Relationship between the Second-to-Fourth Digit Ratio and Behavioral Sexual Dimorphism in School-Aged Children.

    PubMed

    Mitsui, Takahiko; Araki, Atsuko; Miyashita, Chihiro; Ito, Sachiko; Ikeno, Tamiko; Sasaki, Seiko; Kitta, Takeya; Moriya, Kimihiko; Cho, Kazutoshi; Morioka, Keita; Kishi, Reiko; Shinohara, Nobuo; Takeda, Masayuki; Nonomura, Katsuya

    2016-01-01

    Sexually dimorphic brain development and behavior are known to be influenced by sex hormones exposure in prenatal periods. On the other hand, second-to forth digit ratio (2D/4D) has been used as an indirect method to investigate the putative effects of prenatal exposure to androgen. In the present study, we herein investigated the relationship between gender-role play behavior and the second-to-fourth digit ratio (2D/4D), which has been used as an indirect method to investigate the putative effects of prenatal exposure to androgens, in school-aged children. Among 4981 children who became 8 years old by November 2014 and were contactable for this survey by The Hokkaido Study of Environment and Children's Health, 1631 (32.7%), who had data for 2D/4D and Pre-school Activities Inventory (PSAI) as well as data for the survey at baseline, were available for analysis. Parents sent reports of PSAI on the sex-typical characteristics, preferred toys, and play activities of children, and black and white photocopies of the left and right hand palms via mail. PSAI consisted of 12 masculine items and 12 feminine items, and a composite score was created by subtracting the feminine score from the masculine score, with higher scores representing masculine-typical behavior. While composite scores in PSAI were significantly higher in boys than in girls, 2D/4D was significantly lower in boys than in girls. Although the presence or absence of brothers or sisters affected the composite, masculine, and feminine scored of PSAI, a multivariate regression model revealed that 2D/4D negatively correlated with the composite scores of PSAI in boys, whereas no correlation was found in girls. Although 2D/4D negatively correlated with the masculine score in boys and girls, no correlation was observed between 2D/4D and the feminine score. In conclusion, although social factors, such as the existence of brother or sisters, affect dimorphic brain development and behavior in childhood, the present

  11. The Relationship between the Second-to-Fourth Digit Ratio and Behavioral Sexual Dimorphism in School-Aged Children.

    PubMed

    Mitsui, Takahiko; Araki, Atsuko; Miyashita, Chihiro; Ito, Sachiko; Ikeno, Tamiko; Sasaki, Seiko; Kitta, Takeya; Moriya, Kimihiko; Cho, Kazutoshi; Morioka, Keita; Kishi, Reiko; Shinohara, Nobuo; Takeda, Masayuki; Nonomura, Katsuya

    2016-01-01

    Sexually dimorphic brain development and behavior are known to be influenced by sex hormones exposure in prenatal periods. On the other hand, second-to forth digit ratio (2D/4D) has been used as an indirect method to investigate the putative effects of prenatal exposure to androgen. In the present study, we herein investigated the relationship between gender-role play behavior and the second-to-fourth digit ratio (2D/4D), which has been used as an indirect method to investigate the putative effects of prenatal exposure to androgens, in school-aged children. Among 4981 children who became 8 years old by November 2014 and were contactable for this survey by The Hokkaido Study of Environment and Children's Health, 1631 (32.7%), who had data for 2D/4D and Pre-school Activities Inventory (PSAI) as well as data for the survey at baseline, were available for analysis. Parents sent reports of PSAI on the sex-typical characteristics, preferred toys, and play activities of children, and black and white photocopies of the left and right hand palms via mail. PSAI consisted of 12 masculine items and 12 feminine items, and a composite score was created by subtracting the feminine score from the masculine score, with higher scores representing masculine-typical behavior. While composite scores in PSAI were significantly higher in boys than in girls, 2D/4D was significantly lower in boys than in girls. Although the presence or absence of brothers or sisters affected the composite, masculine, and feminine scored of PSAI, a multivariate regression model revealed that 2D/4D negatively correlated with the composite scores of PSAI in boys, whereas no correlation was found in girls. Although 2D/4D negatively correlated with the masculine score in boys and girls, no correlation was observed between 2D/4D and the feminine score. In conclusion, although social factors, such as the existence of brother or sisters, affect dimorphic brain development and behavior in childhood, the present

  12. Unusual Ratio between Free Thyroxine and Free Triiodothyronine in a Long-Lived Mole-Rat Species with Bimodal Ageing

    PubMed Central

    Henning, Yoshiyuki; Vole, Christiane; Begall, Sabine; Bens, Martin; Broecker-Preuss, Martina; Sahm, Arne; Szafranski, Karol; Burda, Hynek; Dammann, Philip

    2014-01-01

    Ansell's mole-rats (Fukomys anselli) are subterranean, long-lived rodents, which live in eusocial families, where the maximum lifespan of breeders is twice as long as that of non-breeders. Their metabolic rate is significantly lower than expected based on allometry, and their retinae show a high density of S-cone opsins. Both features may indicate naturally low thyroid hormone levels. In the present study, we sequenced several major components of the thyroid hormone pathways and analyzed free and total thyroxine and triiodothyronine in serum samples of breeding and non-breeding F. anselli to examine whether a) their thyroid hormone system shows any peculiarities on the genetic level, b) these animals have lower hormone levels compared to euthyroid rodents (rats and guinea pigs), and c) reproductive status, lifespan and free hormone levels are correlated. Genetic analyses confirmed that Ansell's mole-rats have a conserved thyroid hormone system as known from other mammalian species. Interspecific comparisons revealed that free thyroxine levels of F. anselli were about ten times lower than of guinea pigs and rats, whereas the free triiodothyronine levels, the main biologically active form, did not differ significantly amongst species. The resulting fT4:fT3 ratio is unusual for a mammal and potentially represents a case of natural hypothyroxinemia. Comparisons with total thyroxine levels suggest that mole-rats seem to possess two distinct mechanisms that work hand in hand to downregulate fT4 levels reliably. We could not find any correlation between free hormone levels and reproductive status, gender or weight. Free thyroxine may slightly increase with age, based on sub-significant evidence. Hence, thyroid hormones do not seem to explain the different ageing rates of breeders and non-breeders. Further research is required to investigate the regulatory mechanisms responsible for the unusual proportion of free thyroxine and free triiodothyronine. PMID:25409169

  13. Unusual ratio between free thyroxine and free triiodothyronine in a long-lived mole-rat species with bimodal ageing.

    PubMed

    Henning, Yoshiyuki; Vole, Christiane; Begall, Sabine; Bens, Martin; Broecker-Preuss, Martina; Sahm, Arne; Szafranski, Karol; Burda, Hynek; Dammann, Philip

    2014-01-01

    Ansell's mole-rats (Fukomys anselli) are subterranean, long-lived rodents, which live in eusocial families, where the maximum lifespan of breeders is twice as long as that of non-breeders. Their metabolic rate is significantly lower than expected based on allometry, and their retinae show a high density of S-cone opsins. Both features may indicate naturally low thyroid hormone levels. In the present study, we sequenced several major components of the thyroid hormone pathways and analyzed free and total thyroxine and triiodothyronine in serum samples of breeding and non-breeding F. anselli to examine whether a) their thyroid hormone system shows any peculiarities on the genetic level, b) these animals have lower hormone levels compared to euthyroid rodents (rats and guinea pigs), and c) reproductive status, lifespan and free hormone levels are correlated. Genetic analyses confirmed that Ansell's mole-rats have a conserved thyroid hormone system as known from other mammalian species. Interspecific comparisons revealed that free thyroxine levels of F. anselli were about ten times lower than of guinea pigs and rats, whereas the free triiodothyronine levels, the main biologically active form, did not differ significantly amongst species. The resulting fT4:fT3 ratio is unusual for a mammal and potentially represents a case of natural hypothyroxinemia. Comparisons with total thyroxine levels suggest that mole-rats seem to possess two distinct mechanisms that work hand in hand to downregulate fT4 levels reliably. We could not find any correlation between free hormone levels and reproductive status, gender or weight. Free thyroxine may slightly increase with age, based on sub-significant evidence. Hence, thyroid hormones do not seem to explain the different ageing rates of breeders and non-breeders. Further research is required to investigate the regulatory mechanisms responsible for the unusual proportion of free thyroxine and free triiodothyronine.

  14. Gender ratio in a clinical population sample, age of diagnosis and duration of assessment in children and adults with autism spectrum disorder.

    PubMed

    Rutherford, Marion; McKenzie, Karen; Johnson, Tess; Catchpole, Ciara; O'Hare, Anne; McClure, Iain; Forsyth, Kirsty; McCartney, Deborah; Murray, Aja

    2016-07-01

    This article reports on gender ratio, age of diagnosis and the duration of assessment procedures in autism spectrum disorder diagnosis in a national study which included all types of clinical services for children and adults. Findings are reported from a retrospective case note analysis undertaken with a representative sample of 150 Scottish children and adults recently diagnosed with autism spectrum disorder. The study reports key findings that the gender ratio in this consecutively referred cohort is lower than anticipated in some age groups and reduces with increasing age. The gender ratio in children, together with the significant difference in the mean age of referral and diagnosis for girls compared to boys, adds evidence of delayed recognition of autism spectrum disorder in younger girls. There was no significant difference in duration of assessment for males and females suggesting that delays in diagnosis of females occur prior to referral for assessment. Implications for practice and research are considered.

  15. MASS-TO-LIGHT RATIOS FOR M31 GLOBULAR CLUSTERS: AGE DATING AND A SURPRISING METALLICITY TREND

    SciTech Connect

    Strader, Jay; Huchra, John P.; Smith, Graeme H.; Brodie, Jean P.

    2009-08-15

    We have obtained velocity dispersions from Keck high-resolution integrated spectroscopy of 10 M31 globular clusters (GCs), including three candidate intermediate-age GCs. We show that these candidates have the same V-band mass-to-light (M/L{sub V} ) ratios as the other GCs, implying that they are likely to be old. We also find a trend of derived velocity dispersion with wavelength, but cannot distinguish between a systematic error and a physical effect. Our new measurements are combined with photometric and spectroscopic data from the literature in a re-analysis of all M31 GC M/L{sub V} values. In a combined sample of 27 GCs, we show that the metal-rich GCs have lower M/L{sub V} than the metal-poor GCs, in conflict with predictions from stellar population models. Fragmentary data for other galaxies support this observation. The M31 GC fundamental plane is extremely tight, and we follow up an earlier suggestion by Djorgovski to show that the fundamental plane can be used to estimate accurate distances (potentially 10% or better)

  16. A rapid method for determining arachidonic:eicosapentaenoic acid ratios in whole blood lipids: correlation with erythrocyte membrane ratios and validation in a large Italian population of various ages and pathologies

    PubMed Central

    2010-01-01

    Background Omega-3 and -6 polyunsaturated fatty acids (LCPUFA), are important for good health conditions. They are present in membrane phospholipids. The ratio of total n-6:n-3 LCPUFA and arachidonic acid:eicosapentaenoic acid (AA and EPA), should not exceed 5:1. Increased intake of n-6 and decreased consumption of n-3 has resulted in much higher, ca 10/15:1 ratio in RBC fatty acids with the possible appearance of a pathological "scenario". The determination of RBC phospholipid LCPUFA contents and ratios is the method of choice for assessing fatty acid status but it is labour intensive and time consuming. Aims of the study [i] To describe and validate a rapid method, suitable for large scale population studies, for total blood fatty acid assay; [ii] to verify a possible correlation between total n-6:n-3 ratio and AA:EPA ratios in RBC phospholipids and in whole-blood total lipids, [iii] to assess usefulness of these ratio as biomarkers of LCPUFA status. Methods [1] Healthy volunteers and patients with various pathologies were recruited. [2] Fatty acid analyses by GC of methyl esters from directly derivatized whole blood total lipids and from RBC phospholipids were performed on fasting blood samples from 1432 subjects categorised according to their age, sex and any existing pathologies. AA:EPA ratio and the total n-6:n-3 ratio were determined. Results AA:EPA ratio is a more sensitive and reliable index for determining changes in total blood fatty acid and it is correlated with the ratio derived from extracted RBC phospholipids. Conclusions The described AA:EPA ratio is a simple, rapid and reliable method for determining n-3 fatty acid status. PMID:20105293

  17. Low-speed wind-tunnel investigation of forward-located spoilers and trailing splines as trailing-vortex hazard-alleviation devices on an aspect-ratio-8 wing model

    NASA Technical Reports Server (NTRS)

    Croom, D. R.

    1975-01-01

    An investigation was made in the Langley V/STOL tunnel in order to determine, by the trailing-wing sensor technique, the effectiveness of either a forward-mounted spoiler or a tip-mounted spline as trailing-vortex attenuation devices on an unswept aspect-ratio-8 wing model. The trailing-wing rolling-moment data taken in the tunnel diffuser section show good agreement with the data taken in the tunnel test section. This agreement indicates that reasonable results may be obtained in the Langley V/STOL tunnel in experimental investigations of the trailing-vortex hazard at relatively great distances behind aircraft models.

  18. (CALIFORNIA) META-ANALYSIS OF THE LIFE STYLE FACTORS RELEVANT TO ENVIRONMENTAL HAZARDS FOR THE AGING POPULATION

    EPA Science Inventory

    The goal of this U.S. Environmental Protection Agency (EPA) Aging Initiative study is to characterize activity patterns, physiological changes, and environmental exposures for the aging population. Meta-analysis was performed on more than 2000 reviewed articles to evaluate the l...

  19. Gender Ratio in a Clinical Population Sample, Age of Diagnosis and Duration of Assessment in Children and Adults with Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Rutherford, Marion; McKenzie, Karen; Johnson, Tess; Catchpole, Ciara; O'Hare, Anne; McClure, Iain; Forsyth, Kirsty; McCartney, Deborah; Murray, Aja

    2016-01-01

    This article reports on gender ratio, age of diagnosis and the duration of assessment procedures in autism spectrum disorder diagnosis in a national study which included all types of clinical services for children and adults. Findings are reported from a retrospective case note analysis undertaken with a representative sample of 150 Scottish…

  20. Hazardous Waste

    MedlinePlus

    ... you throw these substances away, they become hazardous waste. Some hazardous wastes come from products in our homes. Our garbage can include such hazardous wastes as old batteries, bug spray cans and paint ...

  1. 40Ar/39Ar laser probe evidence concerning the age and associated hazards of the Lake Nyos Maar, Cameroon

    USGS Publications Warehouse

    Dalrymple, G.B.; Lockwood, J.P.

    1990-01-01

    The waters of Lake Nyos are impounded by a fragile natural dam composed of pyroclastic rocks ejected during the formation of the lake crater (maar). Lateral erosion of this dam has reduced its width from over 500 m to only 45 m. Published whole-rock K-Ar ages of about 100 ka on juvenile basalt from the dam suggests that erosion has been slow and that the dam poses no imminent threat. New apparent 40Ar/39Ar ages of 1.4 to 232 Ma on xenocrystic K-feldspar contained in the basalt show that the xenocrysts, whose source is the 528-Ma crystalline basement, are carriers of inherited radiogenic 40Ar and would cause the whole-rock K-Ar ages to be too old. The best estimate for the age of the maar is provided by a 14C age of 400 ?? 100 yr BP on charcoal from the base of the dam. This young age indicates that the dam is eroding at a relatively rapid rate; its failure, perhaps within a few decades, would result in a major flood and imperil thousands of people living downstream in Cameroon and eastern Nigeria. ?? 1990 Kluwer Academic Publishers.

  2. The role of social networks and media receptivity in predicting age of smoking initiation: a proportional hazards model of risk and protective factors.

    PubMed

    Unger, J B; Chen, X

    1999-01-01

    The increasing prevalence of adolescent smoking demonstrates the need to identify factors associated with early smoking initiation. Previous studies have shown that smoking by social network members and receptivity to pro-tobacco marketing are associated with smoking among adolescents. It is not clear, however, whether these variables also are associated with the age of smoking initiation. Using data from 10,030 California adolescents, this study identified significant correlates of age of smoking initiation using bivariate methods and a multivariate proportional hazards model. Age of smoking initiation was earlier among those adolescents whose friends, siblings, or parents were smokers, and among those adolescents who had a favorite tobacco advertisement, had received tobacco promotional items, or would be willing to use tobacco promotional items. Results suggest that the smoking behavior of social network members and pro-tobacco media influences are important determinants of age of smoking initiation. Because early smoking initiation is associated with higher levels of addiction in adulthood, tobacco control programs should attempt to counter these influences. PMID:10400276

  3. In-office survey of children's hazard exposure in the Chicago area: age-specific exposure information and methodological lessons. Pediatric Practice Research Group.

    PubMed

    Senturia, Y D; Binns, H J; Christoffel, K K; Tanz, R R

    1993-06-01

    Anticipatory guidance on injury prevention should reflect the risks children face, yet hazard exposure information is generally unavailable. The objectives of this study were (1) to obtain information on age-specific exposure of Chicago-area children to amusement park rides, sleds, snow discs, bunkbeds, skateboards, fireworks, toboggans, and air guns and (2) to assess methodological issues in gathering exposure information by parental survey in pediatric practices. Questionnaires were received from 679 families, including 1469 children. The proportion of families with at least one exposed child varied: amusement park rides (94%), sleds (67%), snow discs (25%), bunkbeds (24%), skateboards (22%), fireworks (17%), toboggans (15%), and air guns and rifles (6%). Use of skateboards, air guns and rifles, and bunkbeds was highest in males. Use of skateboards, air guns and rifles, and snow discs peaked among young adolescents (ages 10 to 14), whereas use of sleds, toboggans and amusement park rides peaked among young children (ages 5 to 9) and young adolescents. Use of bunkbeds peaked among young children. Log linear analyses found: the likelihood of exposure to sleds and snow discs was highest in rural communities and for families owning their own home; toboggan exposure was highest among home owners; air gun and rifle exposure was highest in rural areas; fireworks exposure decreased with increased paternal education; exposure to skateboards was highest in single family dwellings and suburban home owners. This study generates the only available current estimates for use of these products, and demonstrates that in-office parental surveys concerning exposure are feasible. The findings can help guide future hazard exposure research and may affect anticipatory guidance in some settings.(ABSTRACT TRUNCATED AT 250 WORDS)

  4. Measurement of the Linear Depolarization Ratio of Aged Dust at Three Wavelengths (355, 532 and 1064 nm) Simultaneously over Barbados

    NASA Astrophysics Data System (ADS)

    Haarig, Moritz; Althausen, Dietrich; Ansmann, Albert; Klepel, André; Baars, Holger; Engelmann, Ronny; Groß, Silke; Freudenthaler, Volker

    2016-06-01

    A ground-based polarization Raman lidar is presented, that is able to measure the depolarization ratio at three wavelengths (355, 532 and 1064 nm) simultaneously. This new feature is implemented for the first time in a Raman lidar. It provides a full dataset of 3 backscatter coefficients, two extinction coefficients and 3 depolarization ratios (3+2+3 lidar system). To ensure the data quality, it has been compared to the well characterized two-wavelength polarization lidar POLIS. Measurements of long-range transported dust have been performed in the framework of the Saharan Aerosol Long-Range Transport and Aerosol-Cloud-Interaction Experiment (SALTRACE) in the Caribbean.

  5. The Left Hand Second to Fourth Digit Ratio (2D:4D) Does Not Discriminate World-Class Female Gymnasts from Age Matched Sedentary Girls

    PubMed Central

    Peeters, Maarten W.; Claessens, Albrecht L.

    2012-01-01

    Introduction The second to fourth-digit-ratio (2D:4D), a putative marker of prenatal androgen action and a sexually dimorphic trait, has been suggested to be related with sports performance, although results are not univocal. If this relation exists, it is most likely to be detected by comparing extreme groups on the continuum of sports performance. Methods In this study the 2D:4D ratio of world-class elite female artistic gymnasts (n = 129), competing at the 1987 Rotterdam World-Championships was compared to the 2D:4D ratio of sedentary age-matched sedentary girls (n = 129), alongside with other anthropometric characteristics including other sexually dimorphic traits such as an androgyny index (Bayer & Bayley) and Heath-Carter somatotype components (endomorphy, mesomorphy, ectomorphy) using AN(C)OVA. 2D:4D was measured on X-rays of the left hand. Results Left hand 2D:4D digit ratio in world class elite female gymnasts (0.921±0.020) did not differ significantly from 2D:4D in age-matched sedentary girls (0.924±0.018), either with or without inclusion of potentially confounding covariates such as skeletal age, height, weight, somatotype components or androgyny index. Height (161.9±6.4 cm vs 155.4±6.6 cm p<0.01), weight (53.9±7.6 kg vs 46.2 6.3 kg p<0.01), BMI (20.51±2.41 kg/m2 vs 19.05±1.56 kg/m2), skeletal age (15.2±1.1 y vs 14.5±1.2 y p>0.01), somatotype components (4.0/3.0/2.9 vs 1.7/3.7/3.2 for endomorphy (p<0.01), mesomorphy (p<0.01) and ectomorphy (p<0.05) respectively) all differed significantly between sedentary girls and elite gymnasts. As expressed by the androgyny index, gymnasts have, on average, broader shoulders relative to their hips, compared to the reference sample. Correlations between the 2D:4D ratio and chronological age, skeletal age, and the anthropometric characteristics are low and not significant. Conclusion Although other anthropometric characteristics of sexual dimorphism were significantly different between the two samples

  6. Radiocarbon ages of Holocene Pelado, Guespalapa, and Chichinautzin scoria cones, south of Mexico City: implications for archaeology and future hazards

    NASA Astrophysics Data System (ADS)

    Siebe, Claus; Rodríguez-Lara, Virgilio; Schaaf, Peter; Abrams, Michael

    Pelado, Guespalapa, and Chichinautzin monogenetic scoria cones located within the Sierra del Chichinautzin Volcanic Field (SCVF) at the southern margin of Mexico City were dated by the radiocarbon method at 10,000, 2,800-4,700, and 1,835 years b.p., respectively. Most previous research in this area was concentrated on Xitle scoria cone, whose lavas destroyed and buried the pre-Hispanic town of Cuicuilco around 1,665+/-35 years b.p. The new dates indicate that the recurrence interval for monogenetic eruptions in the central part of the SCVF and close to the vicinity of Mexico City is <2,500 years. If the entire SCVF is considered, the recurrence interval is <1,700 years. Based on fieldwork and Landsat imagery interpretation a geologic map was produced, morphometric parameters characterizing the cones and lava flows determined, and the areal extent and volumes of erupted products estimated. The longest lava flow was produced by Guespalapa and reached 24 km from its source; total areas covered by lava flows from each eruption range between 54 (Chichinautzin) and 80 km2 (Pelado); and total erupted volumes range between 1 and 2 km3/cone. An average eruption rate for the entire SCVF was estimated at 0.6 km3/1,000 years. These findings are of importance for archaeological as well as volcanic hazards studies in this heavily populated region.

  7. Virtual California, ETAS, and OpenHazards web services: Responding to earthquakes in the age of Big Data

    NASA Astrophysics Data System (ADS)

    Yoder, M. R.; Schultz, K.; Rundle, J. B.; Glasscoe, M. T.; Donnellan, A.

    2014-12-01

    The response to the 2014 m=6 Napa earthquake showcased data driven services and technologies that aided first responders and decision makers to quickly assess damage, estimate aftershock hazard, and efficiently allocate resources where where they were most needed. These tools have been developed from fundamental research as part of a broad collaboration -- facilitated in no small party by the California Earthquake Clearinghouse, between researchers, policy makers, and executive decision makers and practiced and honed during numerous disaster response exercises over the past several years. On 24 August 2014, and the weeks following the m=6 Napa event, it became evident that these technologies will play an important role in the response to natural (and other) disasters in the 21st century. Given the continued rapid growth of computational capabilities, remote sensing technologies, and data gathering capacities -- including by unpiloted aerial vehicles (UAVs), it is reasonable to expect that both the volume and variety of data available during a response scenario will grow significantly in the decades to come. Inevitably, modern Data Science will be critical to effective disaster response in the 21st century. In this work, we discuss the roles that earthquake simulators, statistical seismicity models, and remote sensing technologies played in the the 2014 Napa earthquake response. We further discuss "Big Data" technologies and data models that facilitate the transformation of raw data into disseminable information and actionable products, and we outline a framework for the next generation of disaster response data infrastructure.

  8. Post-caldera volcanism: In situ measurement of U-Pb age and oxygen isotope ratio in Pleistocene zircons from Yellowstone caldera

    USGS Publications Warehouse

    Bindeman, I.N.; Valley, J.W.; Wooden, J.L.; Persing, H.M.

    2001-01-01

    The Yellowstone Plateau volcanic field, the site of some of the largest known silicic volcanic eruptions, is the present location of NE-migrating hotspot volcanic activity. Most volcanic rocks in the Yellowstone caldera (0.6 Ma), which formed in response to the climactic eruption of 1000 km3 of Lava Creek Tuff (LCT), have unusually low oxygen isotope ratios. Ion microprobe analysis of both U-Pb age and ??18O in zircons from these low-??18O lavas reveals evidence of complex inheritance and remelting. A majority of analyzed zircons from low-??18O lavas erupted inside the Yellowstone caldera have cores that range in age from 2.4 to 0.7 Ma, significantly older than their eruption ages (0.5-0.4 Ma). These ages and the high-??18O cores indicate that these lavas are largely derived from nearly total remelting of normal-??18O Huckleberry Ridge Tuff (HRT) and other pre-LCT volcanic rocks. A post-HRT low-??18O lava shows similar inheritance of HRT-age zircons. The recycling of volcanic rocks by shallow remelting can change the water content and eruptive potential of magma. This newly proposed mechanism of intracaldera volcanism is best studied by combining in situ analysis of oxygen and U-Pb isotope ratios of individual crystals. ?? 2001 Elsevier Science B.V. All rights reserved.

  9. Membrane skeletal alterations during in vivo mouse red cell aging. Increase in the band 4.1a:4.1b ratio.

    PubMed Central

    Mueller, T J; Jackson, C W; Dockter, M E; Morrison, M

    1987-01-01

    We have examined membrane protein profiles for alterations during red blood cell aging. To obtain populations of in vivo-aged red cells, we maintained mice in a state of continuous erythropoietic suppression for up to 8 wk using serial hypertransfusion. The circulating t1/2 of red cells from mice which had been erythropoietically suppressed for 8 wk was less than 1 d compared with a t1/2 of 15 d for red cells from normal animals. The most obvious alteration in membrane proteins was an increase in the ratio of the membrane skeletal components 4.1a:4.1b from 0.3 for the normal red cell population to greater than 1 for these old cells. The 4.1a:4.1b ratio thus appears to be a useful index of red cell age. Analyses of the density profile of cells aged in the hypertransfused mice disclosed that these old cells had a density range similar to that of controls, suggesting that cell density does not increase significantly with red cell age in the mouse. Images PMID:3805278

  10. Cytomegalovirus infection: an occupational hazard to kindergarten teachers working with children aged 2.5-6 years.

    PubMed

    Kiss, Philippe; De Bacquer, Dirk; Sergooris, Leen; De Meester, Marc; VanHoorne, Michel

    2002-01-01

    The aims of the study were to evaluate the occupational risk of cytomegalovirus (CMV) infection in kindergarten teachers working with children aged 2.5-6 years, and to determine occupational risk factors within the occupation of kindergarten teaching. A cross-sectional seroprevalence study was conducted in 211 kindergarten teachers and 283 administrative workers. Relevant confounding factors were considered. Overall seropositivity rates ranged from 16.4% in childless women to 33.7% in women with one child or more. Raising own children was the major risk factor for CMV seropositivity: adjusted OR 2.25. Kindergarten teaching showed to have a significantly increased CMV seropositivity rate: adjusted OR 1.54. Among kindergarten teachers, washing hands at school, number and age of the pupils, and seniority had no significant influence on seropositivity. The results indicated an increased risk of CMV infection in kindergarten teachers and an insufficiency of hygienic measures to prevent seropositivity. PMID:12019684

  11. Age estimation from pulp/tooth area ratio (PTR) in an Indian sample: A preliminary comparison of three mandibular teeth used alone and in combination.

    PubMed

    Babshet, Medha; Acharya, Ashith B; Naikmasur, Venkatesh G

    2011-11-01

    Pulp/tooth area ratio (PTR) method of adult dental age estimation has been examined on few tooth types. We assessed the lateral incisor (LI) and first premolar (PM1) in addition to canine (C) - alone and in combination. Periapical radiographs from 61 Indians aged 21-71 years were examined. PTR of LI produced the best age correlation (r = -0.395) followed closely by PM1 (r = -0.362). The canine revealed the lowest correlation (r = -0.206); among tooth combinations, the three teeth taken together had the best R value (-0.438) followed by LI + PM1 (-0.435), LI + C (-0.406) and C + PM1 (-0.37). The standard errors of estimates (S.E.E.) of the regression analyses for the individual teeth and tooth combinations ranged from ±12.13 to 13.08 years, indicating minimal difference in age estimates using solitary or multiple teeth. Errors were higher than in European groups (±2.5-5 years) which may partly owe to moderate age correlation of secondary dentine deposition in Indians. Moreover, facial soft-tissue superimposition in living subjects evaluated herein possibly precluded optimal tooth and pulp canal visualization. These indicate that the PTR method should be used judiciously in age estimation of living Indian adults, although further studies on larger samples with evenly distributed age-groups is necessary for deriving definitive conclusions.

  12. Effects of castration age, dietary protein level and lysine/methionine ratio on animal performance, carcass and meat quality of Friesian steers intensively reared.

    PubMed

    Prado, I N; Campo, M M; Muela, E; Valero, M V; Catalan, O; Olleta, J L; Sañudo, C

    2014-09-01

    The effects of castration age, dietary protein level and the dietary lysine/methionine (lys/met) ratio on animal performance, carcass characteristics and meat quality were studied in 64 intensively reared Friesian steers. Animals underwent castration procedures at 15 days old or at 5 months old. Dietary treatments started at 90 days old, with eight animals from each castration age randomly allocated to each treatment: 14.6% v. 16.8% CP (DM basis), and 3.0 v. 3.4 lys/met, on a 2×2×2 design. The recommended ratio of 3.0 was reached with supplementation of protected methionine. Steers were slaughtered at 443.5±26.2 kg live weight when they reached 12 months old approximately. Average daily gain, cold carcass weight or carcass classification were not affected by any studied effect. Muscle moisture (P=0.024), C18:2n-6 percentage (P=0.047), polyunsaturated fatty acid/saturated fatty acid (P=0.049) and n-6/n-3 (P=0.003) were higher in late castrated animals. Both high levels of dietary protein (P=0.008) and lys/met ratio (P=0.048) increased the percentage of muscle in the carcass. A level of 16.8% of CP in the diet also increased the percentage of monounsaturated fatty acids in the intramuscular fat (P=0.032), whereas a ratio lys/met of 3.4 decreased the percentage of saturated fatty acids (P=0.028). Thus, it is recommended using diets with a high protein level (16.8%) and a high lys/met ratio (3.4) in animals slaughtered at a young age, in order to obtain carcasses with high muscle content without negatively affecting productive traits or intramuscular fat composition.

  13. Relative Hazard Calculation Methodology

    SciTech Connect

    DL Strenge; MK White; RD Stenner; WB Andrews

    1999-09-07

    The methodology presented in this document was developed to provide a means of calculating the RH ratios to use in developing useful graphic illustrations. The RH equation, as presented in this methodology, is primarily a collection of key factors relevant to understanding the hazards and risks associated with projected risk management activities. The RH equation has the potential for much broader application than generating risk profiles. For example, it can be used to compare one risk management activity with another, instead of just comparing it to a fixed baseline as was done for the risk profiles. If the appropriate source term data are available, it could be used in its non-ratio form to estimate absolute values of the associated hazards. These estimated values of hazard could then be examined to help understand which risk management activities are addressing the higher hazard conditions at a site. Graphics could be generated from these absolute hazard values to compare high-hazard conditions. If the RH equation is used in this manner, care must be taken to specifically define and qualify the estimated absolute hazard values (e.g., identify which factors were considered and which ones tended to drive the hazard estimation).

  14. Age, growth, sex ratio, and maturity of the whitefish in central Green Bay and adjacent waters of Lake Michigan

    USGS Publications Warehouse

    Mraz, Donald

    1964-01-01

    This study is based on 1,023 whitefish, Coregonus clupeaformis (Mitchill)--819 in seven samples from five localitites in central Green Bay in 1948-49 and 1851-52 and 204 in a single 1948 collection from northwestern Lake Michigan proper. Records of age indicated unusual strength for only one year class--1943 which strongly dominated the 1948 sample from Lake Michigan and the 1949 sample from Green Bay and was well represented in the 1948 collection from green Bay. Collection of 1951-52 without exception were dominated by age group III. Length distributions of samples varied widely according to the age composition. Among fish more than 2 years old, the length distributions of age groups overlapped broadly. Several 1-inch intervals included fish of four age groups. The length-weight relation varied considerably among central Green Bay samples, but differences among localitites were nearly equalled by the year-to-year difference at a single locality. Lake Michigan whitefish were generally lighter than those from Green Bay. Weight increased to the 3.386 power of length in Green Bay (combined samples) and the 3.359 power in Lake Michigan. Growth in length, calculated by direct proportion from diameter measurements of growth fields on scales, differed among localities in central Green Bay and between samples of different years at a single locality. If permanent locality differences exist they are not large and can be obscured by the evident annual fluctuations of growth. The grand average calculated length of Green Bay whitefish (combined collections) exceeded that of Lake Michigan fish in all years of life. The advantage was greatest (2.2 inches) at 3 years (calculated lengths of 16.0 inches and 13.8 inches) and subsequently declined to 0.5 inch at 9 years (lengths of 24.6 and 24.1 inches). Both groups reached the minimum legal length of 17 inches during the fourth growing season. Green Bay whitefish also had the larger calculated weights. The advantage reached 9

  15. Age-at-death estimation by pulp/tooth area ratio in canines: study of a 20th-century Mexican sample of prisoners to test Cameriere's method.

    PubMed

    De Luca, Stefano; Bautista, Josefina; Alemán, Inmaculada; Cameriere, Roberto

    2011-09-01

    Accurate age estimation has always been a problem for forensic scientists, and apposition of secondary dentine is often used as an indicator of age. Cameriere et al. studied the pulp/tooth area ratio by peri-apical X-ray images of the canines, to observe the apposition of secondary dentine. The present study examines the application of this technique in a Mexican identified sample coming from the Department of Physical Anthropology of the INAH, at Mexico City. The main aim of this work is to test the reliability of this method in a skeletal sample of a specific population, different from the samples used for its development. The obtained regression model explained 96.2% of total variance (R(2) = 0.962) with a standard error of estimate of 1.909 and a standard deviation of 1.947. These results demonstrate great reliability and that the age/secondary dentine relationship is not variable in this specific population.

  16. Determination of the provenance of cocoa by soil protolith ages and assessment of anthropogenic lead contamination by pb/nd and lead isotope ratios.

    PubMed

    Manton, William I

    2010-01-27

    The Pb contents of chocolate and the products it flavors are among the highest of all commonly consumed substances. Others have shown that this Pb is acquired by cocoa beans after harvesting and is concentrated in their shells, portions of which are ground up with the cotyledons during processing. It is shown here that the shells also contain the lanthanides Nd and Sm, which they appear to take up more slowly than Pb when dried on bare soil. Consideration of Pb/Nd ratios, model Sm-Nd ages and the isotope ratios of Pb and Sr indicates that, in the absence of contamination, the relationship between Pb and Nd in shells is y = 13.1x(-0.383), where x is the Nd concentration in microg/kg and y is the Pb/Nd ratio. For cocoa powders, the relationship is y = 114x(-0.988). Samples that plot above these curves are probably contaminated. Model ages indicate where the cocoa of cocoa powders is grown, and these same considerations point to African samples being uncontaminated but samples from Asia containing 50% anthropogenic Pb of Australian origin. No measurable Pb contamination occurs during the transport of beans and the manufacture of chocolate.

  17. The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice

    PubMed Central

    Solon-Biet, Samantha M.; McMahon, Aisling C.; Ballard, J. William O.; Ruohonen, Kari; Wu, Lindsay E.; Cogger, Victoria C.; Warren, Alessandra; Huang, Xin; Pichaud, Nicolas; Melvin, Richard G.; Gokarn, Rahul; Khalil, Mamdouh; Turner, Nigel; Cooney, Gregory J.; Sinclair, David A.; Raubenheimer, David; Le Couteur, David G.; Simpson, Stephen J.

    2016-01-01

    Summary The fundamental questions of what represents a macronutritionally balanced diet and how this maintains health and longevity remain unanswered. Here, the Geometric Framework, a state-space nutritional modeling method, was used to measure interactive effects of dietary energy, protein, fat, and carbohydrate on food intake, cardiometabolic phenotype, and longevity in mice fed one of 25 diets ad libitum. Food intake was regulated primarily by protein and carbohydrate content. Longevity and health were optimized when protein was replaced with carbohydrate to limit compensatory feeding for protein and suppress protein intake. These consequences are associated with hepatic mammalian target of rapamycin (mTOR) activation and mitochondrial function and, in turn, related to circulating branched-chain amino acids and glucose. Calorie restriction achieved by high-protein diets or dietary dilution had no beneficial effects on lifespan. The results suggest that longevity can be extended in ad libitum-fed animals by manipulating the ratio of macronutrients to inhibit mTOR activation. PMID:24606899

  18. Effects of castration age, protein level and lysine/methionine ratio in the diet on colour, lipid oxidation and meat acceptability of intensively reared Friesian steers.

    PubMed

    Prado, I N; Campo, M M; Muela, E; Valero, M V; Catalan, O; Olleta, J L; Sañudo, C

    2015-08-01

    A total of 64 intensively reared Friesian steers were used in a 2×2×2 design to study the effects of age of castration (15 days old v. 5 months old), dietary protein level (14.6% v. 16.8%; DM basis) and lysine/methionine (lys/met) ratio (3.0 v. 3.4) on meat quality. The lys/met ratio of 3.0 was reached with supplementation of protected methionine. Animals were slaughtered at a live weight of 443.5 ± 26.2 kg at around 12 months of age. Colour and lipid oxidation were measured in the longissimus thoracis muscle throughout the 14 days of display under modified atmospheric and commercial display conditions. A panel of 17 consumers assessed daily the visual acceptability of the meat on display. A consumer acceptability eating test was also performed with 120 consumers in meat aged for 7 days under vacuum conditions. Lipid oxidation was not influenced by castration age and the protein level in the diet. Castration age did not affect meat colour, but meat from the low protein level diet and the low lys/met ratio showed higher redness (a*) from 3 days of display onwards. Nevertheless, from 6 days onwards, consumer visual acceptability was below the level of acceptance in all treatments, and even from 5 days onwards in those animals that underwent early castration and were fed either a high protein diet or a combination diet low in protein content and high in lys/met ratio. The best accepted treatments throughout the display period were those from late castrated animals fed a low protein diet, probably related to other visual aspects. However, the best accepted meat after consumption was that from late castrated animals fed high protein and high lys/met. The addition of protected methionine to reach lys/met levels of 3.0 did not improve beef acceptability, with the high protein diet being preferred by consumers in terms of palatability in late castrated animals. PMID:26190253

  19. Effects of castration age, protein level and lysine/methionine ratio in the diet on colour, lipid oxidation and meat acceptability of intensively reared Friesian steers.

    PubMed

    Prado, I N; Campo, M M; Muela, E; Valero, M V; Catalan, O; Olleta, J L; Sañudo, C

    2015-08-01

    A total of 64 intensively reared Friesian steers were used in a 2×2×2 design to study the effects of age of castration (15 days old v. 5 months old), dietary protein level (14.6% v. 16.8%; DM basis) and lysine/methionine (lys/met) ratio (3.0 v. 3.4) on meat quality. The lys/met ratio of 3.0 was reached with supplementation of protected methionine. Animals were slaughtered at a live weight of 443.5 ± 26.2 kg at around 12 months of age. Colour and lipid oxidation were measured in the longissimus thoracis muscle throughout the 14 days of display under modified atmospheric and commercial display conditions. A panel of 17 consumers assessed daily the visual acceptability of the meat on display. A consumer acceptability eating test was also performed with 120 consumers in meat aged for 7 days under vacuum conditions. Lipid oxidation was not influenced by castration age and the protein level in the diet. Castration age did not affect meat colour, but meat from the low protein level diet and the low lys/met ratio showed higher redness (a*) from 3 days of display onwards. Nevertheless, from 6 days onwards, consumer visual acceptability was below the level of acceptance in all treatments, and even from 5 days onwards in those animals that underwent early castration and were fed either a high protein diet or a combination diet low in protein content and high in lys/met ratio. The best accepted treatments throughout the display period were those from late castrated animals fed a low protein diet, probably related to other visual aspects. However, the best accepted meat after consumption was that from late castrated animals fed high protein and high lys/met. The addition of protected methionine to reach lys/met levels of 3.0 did not improve beef acceptability, with the high protein diet being preferred by consumers in terms of palatability in late castrated animals.

  20. Effects of growth hormone, melatonin, oestrogens and phytoestrogens on the oxidized glutathione (GSSG)/reduced glutathione (GSH) ratio and lipid peroxidation in aged ovariectomized rats.

    PubMed

    Baeza, Isabel; Fdez-Tresguerres, Jesús; Ariznavarreta, Carmen; De la Fuente, Mónica

    2010-12-01

    Ovariectomy constitutes a commonly used model in rats and mice for human menopause. After ovariectomy, an imbalance between oxidant production and antioxidant levels appears in favour of the former, with increased oxidative stress and consequently an acceleration of ageing. In the present work, the levels of reduced glutathione (GSH), a relevant antioxidant, and oxidized glutathione (GSSG), an oxidant compound, as well as lipid peroxidation (through malondialdehyde (MDA) levels), were studied in liver, heart, kidney and spleen homogenates of old (24 months of age) unovariectomized and ovariectomized female Wistar rats. The results showed a significant increase of the GSSG/GSH ratio, a marker of oxidative stress, and higher MDA production in all the studied organs of ovariectomized rats as compared with unovariectomized animals. These data confirm the idea that ovariectomy accelerates the ageing process. Administration of growth hormone (GH), melatonin (MEL) and oestrogens (OE), as well as soybean phytoestrogens (PE) for 10 weeks, between 22 and 24 months of age, was able to decrease oxidative stress in the investigated organs of ovariectomized old rats, therefore slowing down the ageing process in those animals.

  1. The effect of age and teat order on alpha1-acid glycoprotein, neutrophil-to-lymphocyte ratio, cortisol, and average daily gain in commercial growing pigs.

    PubMed

    Stull, C L; Kachulis, C J; Farley, J L; Koenig, G J

    1999-01-01

    The objectives of the study were to evaluate age and teat order on a performance trait, average daily gain, and on physiological stress indicators, alpha1-acid glycoprotein (AGP), neutrophil-to-lymphocyte ratio (N:L), and cortisol in commercial growing pigs from weaning to market age. Pigs (n = 129) from five commercial California farms were weighed and blood-sampled at 28-d intervals from 28 to 168 d of age. Laboratory assays were performed from blood samples to quantify cortisol, AGP, and N:L. Age and facility effects (P<.001), but not teat order effects (P>.05), were found for all three physiological traits and ADG. Pigs that routinely suckled from teats 1, 4, or 6 (numbered from anterior to posterior on the upper teat bank) had similar (P>.05) ADG and BW throughout the production cycle. No correlation (P> .05) was found between cortisol, AGP, and N:L. The use of these physiological and production traits as stress and health indices of growing pigs in commercial facilities has limitations in comparing data between facilities or different ages of pigs. PMID:10064029

  2. The age, growth, sexual maturity, and sex ratio of the common whitefish, Coregonus clupeaformis (Mitchill), of Lake Huron

    USGS Publications Warehouse

    Van Oosten, John

    1939-01-01

    During five years (1939-43) of nutritional research on pen-reared bobwhite quail at the Patuxent Research Refuge, Bowie, Maryland, observations on picking among birds of all ages showed the following results: 1. Picking occurred on all grains tested: corn, wheat, oats, oat groats, barley, millet, buckwheat, kaffir, and mixtures of cereals. The lowest incidence was with buckwheat as the sole grain in a growing diet....2. Picking occurred on all levels of fiber from one to 11per cent in a growing diet....3. Picking occurred on various grinds of corn, barley, and oats, but was least when these cereals were ground in a hammer mill with 3/32 inch mesh screen....4. The incidence was as high on diets containing animal protein as on those containing no animal protein. ....5. After picking began, the addition of one or two per cent of salt to the diet for several days was effective, in many instances, in checking the disorder. Results at the Refuge and the answers to questionnaires from 222 private propagators of gamebirds showed that in two-thirds. of the cases, treatment with an increased quantity of salt successfully stopped the trouble. As a preventative, however, salt was of little value. Picking occurred on both low and high levels of salt.....6. Supplementing the regular diet with certain feed concentrates such as fishmeal, soybean oil meal, liver meal, or chopped greens offered in a separate feeder for a day or two, was as efficacious as the addition of salt.....7. More picking occurred among quail chicks on a 22 per cent level of protein than on higher levels.....8. There was less picking on diets relished by the birds than on those seemingly unpalatable.....9. There was no correlation. between the amount of floor space per chick and the incidence of picking.....10. Increasing the feeding and drinking space seemed to have a marked beneficial effect.....11. Some adult birds on wire floors resorted to self-picking of their feet after the toes were frost-bitten.

  3. The Associations of Novel Vitamin D3 Metabolic Gene CYP27A1 Polymorphism, Adiponectin/Leptin Ratio, and Metabolic Syndrome in Middle-Aged Taiwanese Males

    PubMed Central

    Liu, Chia-Chu; Huang, Chun-Nung; Lee, Yung-Chin; Chu, Chih-Sheng; Chang, Chu-Fen; Kuo, Po-Lin; Lai, Wen-Ter

    2015-01-01

    Metabolic syndrome (MetS) confers increased risks of cardiovascular disease (CVD). Both vitamin D3 and adipocytokines (especially adiponectin and leptin) have a great impact on CVD and MetS. In vitamin D3 metabolism, the vitamin D3 25-hydroxylase (CYP27A1) and 25-hydroxyvitamin D3 1-alpha-hydroxylase (CYP27B1) are two key enzymes. This study aimed to examine the influence of vitamin D3 CYP27 single nucleotide polymorphisms (SNPs) on adipocytokines and MetS. Cross-sectional data and DNA samples were collected from male volunteers (n = 649, age: 55.7 ± 4.7 years). Two tagging SNPs, CYP27A1 rs4674344 and CYP27B1 rs10877012, were selected from the HapMap project. MetS was significantly associated with the CYP27A1 rs4674344 SNP (P = 0.04) and the ratio of adiponectin/leptin (A/L ratio) was most correlated to the CYP27A1 rs4674344 SNP, appearing to be significantly lower in T-carriers than in AA subjects (3.7 ± 4.0 versus 5.1 ± 6.0, P = 0.001) and significantly negatively associated after adjustment. For each MetS component associated with the CYP27A1 rs4674344 SNP, the A/L ratios were significantly negative in preclinical stage (condition not meeting the individual criteria), except the blood pressure. In conclusion, CYP27A1 rs4674344 SNP, A/L ratio, and MetS are significantly associated and T-carriers might have a higher risk of developing MetS due to low A/L ratios in the preclinical stage. PMID:25628655

  4. Age-dependent changes in the ratio of (R)- and (S)-2-butanol released by virgin females of Dasylepida ishigakiensis (Coleoptera: Scarabaeidae).

    PubMed

    Fujiwara-Tsujii, N; Yasui, H; Wakamura, S; Mochizuki, F; Arakaki, N

    2012-12-01

    The females of the white grub beetle, Dasylepida ishigakiensis, release two enantiomers of 2-butanol, (R)-2-butanol and (S)-2-butanol. The ratio describing the relative proportions of these two enantiomers (R/S ratio) has not yet been investigated. (R)-2-Butanol has been shown to attract males in laboratory and field experiments, whereas (S)-2-butanol tends to inhibit them. To determine the R/S ratio of the 2-butanol emitted by virgin females, we collected 2-butanol from young (53 days old), mature (63 days old) and old females (73 days old) using water, extracted with an SPME fibre and subsequently injected into GC-MS. The major component of the 2-butanol emitted by the young females was (R)-2-butanol, but as the females aged, the component ratio favoured (S)-2-butanol. Young females released an 80:20 mixture of (R)- and (S)-2-butanol, whereas old females released a 45:55 mixture. The EAG response of male antennae to a 50:50 ratio (racemic mixture) showed a similar dose-response curve to that of (R)-2-butanol. The male orientation responses to (R)-2-butanol decreased when the relative proportion of (S)-2-butanol increased. An inhibitory and/or masking effect of (S)-2-butanol on male orientation behaviour was also observed in the flight tunnel assay. These results suggest that males are more strongly attracted to young females than to old females. We also discuss the possibility of using 2-butanol isomers as a control or monitoring agent for this insect.

  5. Contrasting effects of age on the plasma/whole blood lead ratio in men and women with a history of lead exposure

    SciTech Connect

    Barbosa, Fernando; Curtius, Adilson J.; Buzalaf, Marilia R.; Tanus-Santos, Jose E.

    2006-09-15

    We examined the effect of age and sex on the relationship between the concentrations of Pb in blood (Pb-B) and in plasma (Pb-P) in an adult population with a history of lead exposure. Pb-P was determined by inductively coupled plasma mass spectrometry (ICP-MS) and Pb-B by graphite furnace atomic absorption spectrometry (GF AAS). We studied 154 adults (56 men and 98 women) from 18 to 60-year old. Pb-B levels varied from 10.0 to 428.0 {mu}g/L, with a mean of 76 {mu}g/L. Blood lead levels varied from 10.0 to 428.0 {mu}g/L in men (mean, 98.3 {mu}g/L) and from 10.0 to 263.0 {mu}g/L (mean, 62.8 {mu}g/L) in women. Corresponding Pb-Ps were 0.02-2.9 {mu}g/L (mean, 0.66 {mu}g/L) and 0.02-1.5 {mu}g/L (mean, 0.42 {mu}g/L) in men and women, respectively. The relationship between Pb-B and Pb-P was found to be curvilinear (r=0.757, P<0.001 Spearman's correlation). The two quantities are related by the line y=0.0006x {sup 1492} (y=Pb-P, and x=Pb-B). The %Pb-P/Pb-B ratio ranged from 0.03% to 1.85%. A positive association was found between %Pb-P/Pb-B ratio and Pb-B levels. When data were separated by sex, this association was also relevant for men (y=0.0184x {sup 0.702}) and women (y=0.0534x {sup 0.5209}) (y=%Pb-P/Pb-B and x=Pb-B). Moreover, we found an interesting positive correlation between Log (Pb-P/Pb-B) and age for women (r=0.31, P<0.0001) and a negative correlation for men (r=-0.164, P=0.07). Taken together, these results suggest contrasting effects of age on the plasma/whole blood lead ratio in men and women with a history of lead exposure. Moreover, sex might play an important role in the metabolism of lead, implying further consideration on the kinetic models constructed of lead toxicity.

  6. Hazardous materials

    MedlinePlus

    ... people how to work with hazardous materials and waste. There are many different kinds of hazardous materials, including: Chemicals, like some that are used for cleaning Drugs, like chemotherapy to treat cancer Radioactive material that is used for x-rays or ...

  7. Variance in age-specific sex composition of Pacific halibut catches, and comparison of statistical and genetic methods for reconstructing sex ratios

    NASA Astrophysics Data System (ADS)

    Loher, Timothy; Woods, Monica A.; Jimenez-Hidalgo, Isadora; Hauser, Lorenz

    2016-01-01

    Declines in size at age of Pacific halibut Hippoglossus stenolepis, in concert with sexually-dimorphic growth and a constant minimum commercial size limit, have led to the expectation that the sex composition of commercial catches should be increasingly female-biased. Sensitivity analyses suggest that variance in sex composition of landings may be the most influential source of uncertainty affecting current understanding of spawning stock biomass. However, there is no reliable way to determine sex at landing because all halibut are eviscerated at sea. In 2014, a statistical method based on survey data was developed to estimate the probability that fish of any given length at age (LAA) would be female, derived from the fundamental observation that large, young fish are likely female whereas small, old fish have a high probability of being male. Here, we examine variability in age-specific sex composition using at-sea commercial and closed-season survey catches, and compare the accuracy of the survey-based LAA technique to genetic markers for reconstructing the sex composition of catches. Sexing by LAA performed best for summer-collected samples, consistent with the hypothesis that the ability to characterize catches can be influenced by seasonal demographic shifts. Additionally, differences between survey and commercial selectivity that allow fishers to harvest larger fish within cohorts may generate important mismatch between survey and commercial datasets. Length-at-age-based estimates ranged from 4.7% underestimation of female proportion to 12.0% overestimation, with mean error of 5.8 ± 1.5%. Ratios determined by genetics were closer to true sample proportions and displayed less variability; estimation to within < 1% of true ratios was limited to genetics. Genetic estimation of female proportions ranged from 4.9% underestimation to 2.5% overestimation, with a mean absolute error of 1.2 ± 1.2%. Males were generally more difficult to assign than females: 6.7% of

  8. Lower Protein-to-Carbohydrate Ratio in Maternal Diet is Associated with Higher Childhood Systolic Blood Pressure up to Age Four Years.

    PubMed

    Blumfield, Michelle L; Nowson, Caryl; Hure, Alexis J; Smith, Roger; Simpson, Stephen J; Raubenheimer, David; MacDonald-Wicks, Lesley; Collins, Clare E

    2015-05-01

    The prenatal environment can influence development of offspring blood pressure (BP), which tracks into adulthood. This prospective longitudinal study investigated whether maternal pregnancy dietary intake is associated with the development of child BP up to age four years. Data are from 129 mother-child dyads enrolled in the Women and Their Children's Health study. Maternal diet was assessed using a validated 74-item food frequency questionnaire at 18 to 24 weeks and 36 to 40 weeks, with a reference period of the previous three months. Child systolic and diastolic BP were measured at 3, 6, 9, 12, 24, 36 and 48 months, using an automated BP monitor. Using mixed-model regression analyses adjusted for childhood growth indices, pregnancy intakes of percentage of energy (E%) polyunsaturated fat (β coefficient 0.73; 95% CI 0.003, 1.45; p = 0.045), E% omega-6 fatty acids (β coefficient 0.89; 95% CI 0.09, 1.69; p = 0.03) and protein-to-carbohydrate (P:C) ratio (β coefficient -14.14; 95% CI -27.68, -0.60; p = 0.04) were associated with child systolic BP trajectory up to 4 years. Child systolic BP was greatest at low proportions of dietary protein (<16% of energy) and high carbohydrate (>40% of energy) intakes. There may be an ideal maternal macronutrient ratio associated with optimal infant BP. Maternal diet, which is potentially modifiable, may play an important role in influencing offspring risk of future hypertension.

  9. Carbon Structure Hazard Control

    NASA Technical Reports Server (NTRS)

    Yoder, Tommy; Greene, Ben; Porter, Alan

    2015-01-01

    Carbon composite structures are widely used in virtually all advanced technology industries for a multitude of applications. The high strength-to-weight ratio and resistance to aggressive service environments make them highly desirable. Automotive, aerospace, and petroleum industries extensively use, and will continue to use, this enabling technology. As a result of this broad range of use, field and test personnel are increasingly exposed to hazards associated with these structures. No single published document exists to address the hazards and make recommendations for the hazard controls required for the different exposure possibilities from damaged structures including airborne fibers, fly, and dust. The potential for personnel exposure varies depending on the application or manipulation of the structure. The effect of exposure to carbon hazards is not limited to personnel, protection of electronics and mechanical equipment must be considered as well. The various exposure opportunities defined in this document include pre-manufacturing fly and dust, the cured structure, manufacturing/machining, post-event cleanup, and post-event test and/or evaluation. Hazard control is defined as it is applicable or applied for the specific exposure opportunity. The carbon exposure hazard includes fly, dust, fiber (cured/uncured), and matrix vapor/thermal decomposition products. By using the recommendations in this document, a high level of confidence can be assured for the protection of personnel and equipment.

  10. Reproductive Hazards

    MedlinePlus

    ... and female reproductive systems play a role in pregnancy. Problems with these systems can affect fertility and ... a reproductive hazard can cause different effects during pregnancy, depending on when she is exposed. During the ...

  11. Coastal Hazards.

    ERIC Educational Resources Information Center

    Vandas, Steve

    1998-01-01

    Focuses on hurricanes and tsunamis and uses these topics to address other parts of the science curriculum. In addition to a discussion on beach erosion, a poster is provided that depicts these natural hazards that threaten coastlines. (DDR)

  12. An increased neutrophil-lymphocyte ratio in Alzheimer's disease is a function of age and is weakly correlated with neocortical amyloid accumulation.

    PubMed

    Rembach, Alan; Watt, Andrew D; Wilson, William J; Rainey-Smith, Stephanie; Ellis, Kathryn A; Rowe, Christopher C; Villemagne, Victor L; Macaulay, S Lance; Bush, Ashley I; Martins, Ralph N; Ames, David; Masters, Colin L; Doecke, James D

    2014-08-15

    Inflammation is a hallmark of Alzheimer's disease (AD). Whether directly involved in the pathogenesis, or a downstream consequence of neuronal death, the blood neutrophil-lymphocyte ratio (NLR) is reported to be a putative, non-invasive peripheral biomarker for AD. The aim of this study was to re-evaluate the diagnostic utility of longitudinal measures of the NLR. The NLR was stable across all time-points and weakly correlated with neocortical amyloid burden (R=0.21 at baseline, 0.27 at 18 months, 0.20 at 36 months and 0.10 at 54 months). Cross-sectionally, the NLR was significantly elevated in AD participants as compared to HC participants at baseline (p<0.0001), 18 months (p<0.0001), 36 months (p=0.002) and at 54 months (p=0.007), however only prior to adjustment for age, sex and APOEε4 allele status (p>0.05 at all time-points except for 18 months; p<0.0001). Longitudinally, the NLR was not significantly different between HC and AD participants (p>0.05) adjusted for age, sex and APOEε4 allele status. Comparing the NLR between cognitive transition groups over time (transition towards an AD type dementia), there was no significant difference in the NLR levels between those participants, who did not transition and those participants who did transition, or those in the stable AD group after adjusting for age, sex and APOEε4 allele status (p>0.05). Despite inflammation being a hallmark in AD and previous reports showing that the NLR can discriminate HC from AD patients, our results suggest that the sensitivity of the NLR itself is not robust enough for diagnostic utility. We identified significant relationships cross sectionally (p<0.05 at baseline, 18 months and 36 months) between the NLR and neocortical amyloid burden, but this relationship was lost after longitudinal analyses (p>0.5). The NLR also had limited association with cognitive decline, although in our cohort, the number of participants transitioning was relatively small. In conclusion, the NLR may

  13. An increased neutrophil-lymphocyte ratio in Alzheimer's disease is a function of age and is weakly correlated with neocortical amyloid accumulation.

    PubMed

    Rembach, Alan; Watt, Andrew D; Wilson, William J; Rainey-Smith, Stephanie; Ellis, Kathryn A; Rowe, Christopher C; Villemagne, Victor L; Macaulay, S Lance; Bush, Ashley I; Martins, Ralph N; Ames, David; Masters, Colin L; Doecke, James D

    2014-08-15

    Inflammation is a hallmark of Alzheimer's disease (AD). Whether directly involved in the pathogenesis, or a downstream consequence of neuronal death, the blood neutrophil-lymphocyte ratio (NLR) is reported to be a putative, non-invasive peripheral biomarker for AD. The aim of this study was to re-evaluate the diagnostic utility of longitudinal measures of the NLR. The NLR was stable across all time-points and weakly correlated with neocortical amyloid burden (R=0.21 at baseline, 0.27 at 18 months, 0.20 at 36 months and 0.10 at 54 months). Cross-sectionally, the NLR was significantly elevated in AD participants as compared to HC participants at baseline (p<0.0001), 18 months (p<0.0001), 36 months (p=0.002) and at 54 months (p=0.007), however only prior to adjustment for age, sex and APOEε4 allele status (p>0.05 at all time-points except for 18 months; p<0.0001). Longitudinally, the NLR was not significantly different between HC and AD participants (p>0.05) adjusted for age, sex and APOEε4 allele status. Comparing the NLR between cognitive transition groups over time (transition towards an AD type dementia), there was no significant difference in the NLR levels between those participants, who did not transition and those participants who did transition, or those in the stable AD group after adjusting for age, sex and APOEε4 allele status (p>0.05). Despite inflammation being a hallmark in AD and previous reports showing that the NLR can discriminate HC from AD patients, our results suggest that the sensitivity of the NLR itself is not robust enough for diagnostic utility. We identified significant relationships cross sectionally (p<0.05 at baseline, 18 months and 36 months) between the NLR and neocortical amyloid burden, but this relationship was lost after longitudinal analyses (p>0.5). The NLR also had limited association with cognitive decline, although in our cohort, the number of participants transitioning was relatively small. In conclusion, the NLR may

  14. Reporting Hazards: Their Benefits and Costs.

    ERIC Educational Resources Information Center

    Singer, Eleanor; Endreny, Phyllis

    1987-01-01

    Analyzes the kind and amount of information the media provide about risks and benefits for various hazards. Indicates that the media emphasize hazards that are relatively serious and rare--the combination gives the punch. Ratio of benefits to costs depends upon the particular hazard being covered and reflects general cycles of optimism and…

  15. Shifts in bryophyte carbon isotope ratio across an elevation × soil age matrix on Mauna Loa, Hawaii: do bryophytes behave like vascular plants?

    PubMed

    Waite, Mashuri; Sack, Lawren

    2011-05-01

    The carbon isotope ratio (δ(13)C) of vascular plant leaf tissue is determined by isotope discrimination, primarily mediated by stomatal and mesophyll diffusion resistances and by photosynthetic rate. These effects lead to predictable trends in leaf δ(13)C across natural gradients of elevation, irradiance and nutrient supply. Less is known about shifts in δ(13)C for bryophytes at landscape scale, as bryophytes lack stomata in the dominant gametophyte phase, and thus lack active control over CO(2) diffusion. Twelve bryophyte species were sampled across a matrix of elevation and soil ages on Mauna Loa, Hawaii Island. We tested hypotheses based on previous findings for vascular plants, which tend to have less negative δ(13)C at higher elevations or irradiances, and for leaves with higher leaf mass per area (LMA). Across the matrix, bryophytes spanned the range of δ(13)C values typical of C(3) vascular plants. Bryophytes were remarkably similar to vascular plants in exhibiting less negative δ(13)C with increasing elevation, and with lower overstory cover; additionally δ(13)C was related to bryophyte canopy projected mass per area, a trait analogous to LMA in vascular plants, also correlated negatively with overstory cover. The similarity of responses of δ(13)C in bryophytes and vascular plants to environmental factors, despite differing morphologies and diffusion pathways, points to a strong direct role of photosynthetic rate in determining δ(13)C variation at the landscape scale.

  16. Long-lived crowded-litter mice have an age-dependent increase in protein synthesis to DNA synthesis ratio and mTORC1 substrate phosphorylation.

    PubMed

    Drake, Joshua C; Bruns, Danielle R; Peelor, Frederick F; Biela, Laurie M; Miller, Richard A; Hamilton, Karyn L; Miller, Benjamin F

    2014-11-01

    Increasing mouse litter size [crowded litter (CL)] presumably imposes a transient nutrient stress during suckling and extends lifespan through unknown mechanisms. Chronic calorically restricted and rapamycin-treated mice have decreased DNA synthesis and mTOR complex 1 (mTORC1) signaling but maintained protein synthesis, suggesting maintenance of existing cellular structures. We hypothesized that CL would exhibit similar synthetic and signaling responses to other long-lived models and, by comparing synthesis of new protein to new DNA, that insight may be gained into the potential preservation of existing cellular structures in the CL model. Protein and DNA synthesis was assessed in gastroc complex, heart, and liver of 4- and 7-mo CL mice. We also examined mTORC1 signaling in 3- and 7-mo aged animals. Compared with controls, 4-mo CL had greater DNA synthesis in gastroc complex with no differences in protein synthesis or mTORC1 substrate phosphorylation across tissues. Seven-month CL had less DNA synthesis than controls in heart and greater protein synthesis and mTORC1 substrate phosphorylation across tissues. The increased new protein-to-new DNA synthesis ratio suggests that new proteins are synthesized more so in existing cells at 7 mo, differing from 4 mo, in CL vs. controls. We propose that, in CL, protein synthesis shifts from being directed toward new cells (4 mo) to maintenance of existing cellular structures (7 mo), independently of decreased mTORC1.

  17. Lipid D/H Ratios from Multiple Sources and Deposits Indicate Drier Little Ice Age at Washington Island (4°43`N, 160°25`W), Central Pacific

    NASA Astrophysics Data System (ADS)

    Muegler, I.; Sachse, D.; Sachs, J. P.

    2010-12-01

    To compare the sensitivity of biomarker D/H ratios from two distinct climate archives, a lake and a peat bog on the Tropical Pacific Island of Terrania, compound-specific hydrogen isotope ratios (expressed as δD values) were determined on lipid biomarkers from various biological sources deposited in the two climate archives. At present, Terrania or Washington Island (4°43`N, 160°25`W) permanently lies in the intertropical convergence zone (ITCZ) and receives an annual precipitation of 2,903 mm. The interior of this lens shaped island contains a freshwater lake and peat bogs. Previous studies on the lake sediments found evidence for a substantially drier climate at times during the Little Ice Age (AD 1400-1850) based on the lithologic transition from modern freshwater sediments to a sequence of pure cyanobacterial mat in concert with δD values from total lipid extracts (Sachs et al., 2009). Here we report on δD values from lipids of various sources: dinoflagellate algae (dinosterol and a saturated C30 sterol (4α -methyl-24-ethyl-5α -cholestan-3β-ol), microbial sources (diploptene and nC21 alkane) and higher plants (fern-7-ene, β-sitosterol and stigmastanol). Mean δD values from all lipids, measured in both archives, are significantly enriched in deuterium by between 22 and 86‰ during previously inferred drier climate conditions and simultaneously record the transition towards a freshwater lake at around AD1550. Measured δD values of all lipids cover a wide range from -281‰ to -105‰ during freshwater deposition and from -185‰ to -50‰ when climate was drier. In agreement with the observed isotopic difference between lipids produced via the acetogenic and the mevalonic acid biosynthetic pathway δD values for algae and higher plant sterols are depleted in deuterium relative to the nC21 alkane by 150‰ on average. The consistent δD values from dinosterol and 4α -methyl-24-ethyl-5α -cholestan-3β-ol from the lake and peat deposits signify the

  18. Standardised mortality ratio based on the sum of age and percentage total body surface area burned is an adequate quality indicator in burn care: An exploratory review.

    PubMed

    Steinvall, Ingrid; Elmasry, Moustafa; Fredrikson, Mats; Sjoberg, Folke

    2016-02-01

    Standardised Mortality Ratio (SMR) based on generic mortality predicting models is an established quality indicator in critical care. Burn-specific mortality models are preferred for the comparison among patients with burns as their predictive value is better. The aim was to assess whether the sum of age (years) and percentage total body surface area burned (which constitutes the Baux score) is acceptable in comparison to other more complex models, and to find out if data collected from a separate burn centre are sufficient for SMR based quality assessment. The predictive value of nine burn-specific models was tested by comparing values from the area under the receiver-operating characteristic curve (AUC) and a non-inferiority analysis using 1% as the limit (delta). SMR was analysed by comparing data from seven reference sources, including the North American National Burn Repository (NBR), with the observed mortality (years 1993-2012, n=1613, 80 deaths). The AUC values ranged between 0.934 and 0.976. The AUC 0.970 (95% CI 0.96-0.98) for the Baux score was non-inferior to the other models. SMR was 0.52 (95% CI 0.28-0.88) for the most recent five-year period compared with NBR based data. The analysis suggests that SMR based on the Baux score is eligible as an indicator of quality for setting standards of mortality in burn care. More advanced modelling only marginally improves the predictive value. The SMR can detect mortality differences in data from a single centre. PMID:26700877

  19. Inherited structural cytogenetic abnormalities detected incidentally in fetuses diagnosed prenatally: frequency, parental-age associations, sex-ratio trends, and comparisons with rates of mutants.

    PubMed Central

    Hook, E B; Schreinemachers, D M; Willey, A M; Cross, P K

    1984-01-01

    parental age among the inherited abnormalities was noteworthy. Paternal age was elevated for inherited balanced reciprocal structural abnormalities of paternal origin but not of maternal origin. With regard to sex ratio, there was a greater proportion of females than males among the unbalanced rearrangements both inherited and mutant. There was no obvious sex difference among the balanced rearrangements. PMID:6711562

  20. Effect of polysaccharides extract of rhizoma atractylodis macrocephalae on thymus, spleen and cardiac indexes, caspase-3 activity ratio, Smac/DIABLO and HtrA2/Omi protein and mRNA expression levels in aged rats.

    PubMed

    Guo, Ling; Sun, Yong Le; Wang, Ai Hong; Xu, Chong En; Zhang, Meng Yuan

    2012-10-01

    This study was designed to determine the possible protective effect of polysaccharides extract of rhizoma atractylodis macrocephalae on heart function in aged rats. Polysaccharides extract of rhizoma atractylodis macrocephalae was administered to aged rats. Results showed that thymus, spleen and cardiac indexs were significantly increased, whereas caspase-3 activity ratio, Smac/DIABLO and HtrA2/Omi protein expression, Smac/DIABLO and HtrA2/Omi mRNA expression levels were markedly reduced. It can be concluded that polysaccharides extract of rhizoma atractylodis macrocephalae may enhance immunity and improve heart function in aged rats.

  1. NASA Hazard Analysis Process

    NASA Technical Reports Server (NTRS)

    Deckert, George

    2010-01-01

    This viewgraph presentation reviews The NASA Hazard Analysis process. The contents include: 1) Significant Incidents and Close Calls in Human Spaceflight; 2) Subsystem Safety Engineering Through the Project Life Cycle; 3) The Risk Informed Design Process; 4) Types of NASA Hazard Analysis; 5) Preliminary Hazard Analysis (PHA); 6) Hazard Analysis Process; 7) Identify Hazardous Conditions; 8) Consider All Interfaces; 9) Work a Preliminary Hazard List; 10) NASA Generic Hazards List; and 11) Final Thoughts

  2. Health hazards and medical treatment of volunteers aged 18-30 years working in international social projects of non-governmental organizations (NGO).

    PubMed

    Küpper, T; Rieke, B; Neppach, K; Morrison, A; Martin, J

    2014-01-01

    The specific health risk profile and diversity of treatments sought by young volunteers participating in international social projects should differ from those of their older colleagues. In the absence of any data to identify whether this was correct, a retrospective analysis was performed using a standardized questionnaire. Questions included what diseases occurred, and details of the frequency and types of treatment sought during their stay - (e.g. self-treatment, medical/dental intervention, or local healer). The 153 participants were aged 18-30 years and worked in a non-governmental organization for >6 months. The participants were: 53% female, mean age 20 years, and mean duration of stay was 11.2 months. Their NGO placement abroad was in Latin America 65.4%, 14.4% in Africa, and 9.8% in Asia. 83% of the young volunteers had received some advice regarding travel medicine before their departure. However, they suffered from more injuries compared to private travellers, and febrile infections were more common when compared to older studies. 21.2% suffered from dental problems and 50% of them sought medical treatment. This study highlights a previously unreported higher risk profile of specific health problems occurring in young NGO volunteers, including some potentially life-threatening diagnoses that differed from their older colleagues and normal travellers. It is recommended that young volunteers should receive age specific, comprehensive pre-departure training in health and safety, first aid, and management of common health problems. A medical check-up upon returning home should be mandatory. The provision of a basic first aid kit to each volunteer before departure is also recommended.

  3. Hazards of conveyor belt fires

    SciTech Connect

    Perzak, F.J.; Litton, C.D.; Mura, K.E.; Lazzara, C.P.

    1995-12-31

    This report describes a US Bureau of Mines study on the hazards of large-scale conveyor belt fires in underground coal mines, as a function of both air velocity and distance from belt surface to gallery roof. The fire hazards considered were smoke obscuration, toxic effects of carbon monoxide (CO), and elevated air temperatures downstream of the fire. All of these hazards scale with the ratio of fire intensity to ventilation airflow. These hazards were all found to be greater at the lower belt-to-roof distance, owing to the greater fire intensities that resulted. The hazards of smoke obscuration and elevated CO levels were greater at lower air velocities. Smoke obscuration was found to be the earliest hazard, reaching critical levels before the stages of flame spread. Fire growth rates during rapid flame spread were much greater than rates measured during the early stages of flame spread. Fire growth rates during rapid flame spread were much greater than rates measured during the early stages of belt burning. Data were analyzed to determine the early-warning capability of fire sensors. Smoke sensors provided the earliest warning, followed closely by CO sensors. Thermal sensors did not exhibit any early warning capability.

  4. Health Hazard Evaluations

    MedlinePlus

    ... Products Programs Contact NIOSH HHE Media Health Hazard Evaluations (HHEs) Language: English en Español Recommend on Facebook ... or employers can ask the NIOSH Health Hazard Evaluation (HHE) Program to help learn whether health hazards ...

  5. Relative hazard of radioiodine as a function of (a) radiation quality and (b) age at exposure. Technical report, July 1976-February 1980

    SciTech Connect

    Book, S.A.

    1980-04-01

    To identify the influence of the physical characteristics of radioiodine isotopes and thyroid gland maturity on the effectiveness of radioiodine exposure, two studies were performed: (1) The thyroidal effects of short-lived radioiodines were investigated, using rats to compare the effects of 132I and 131I. The authors found the same effect in goitrogen-stimulated rat thyroid glands (in terms of 50% suppression of thyroid gland weight increase) at doses of about 280 rads from 132I and 2500 rad from 131I, suggesting an approximately 9-fold increase in radiologic effectiveness of 132I over 131I; (2) The differences in age-related radiosensitivity of the guinea pig thyroid gland to radioiodine exposure were examined. Fetal, neonatal, weanling, and adult animals were exposed to single, graded doses of 131I, resulting in thyroid doses up to thousands of rads. Approximately 100 days after dosing, a single microCi of 131I was given and animals were killed 1 day later to provide data on thyroid weight and percent 131I uptake. Results of these data suggested the fetal and weanling thyroid glands were more radiosensitive than the adult thyroids while neonatal thyroids were less sensitive than adults. The extent of the increased radiosensitivity, however, was less than two fold.

  6. Occupational Hazards of Farming

    PubMed Central

    White, Gill; Cessna, Allan

    1989-01-01

    A number of occupational hazards exist for the farmer and farm worker. They include the hazards of farm machinery, biologic and chemical hazards, and social and environmental stresses. Recognizing of these hazards will help the family physician care for farmers and their families. PMID:21248929

  7. The case for dosing dabigatran: how tailoring dose to patient renal function, weight and age could improve the benefit–risk ratio

    PubMed Central

    Safouris, Apostolos; Triantafyllou, Nikos; Parissis, John; Tsivgoulis, Georgios

    2015-01-01

    Dabigatran is increasingly being used in clinical practice for the thromboprophylaxis in atrial fibrillation as a convenient therapy that needs no drug level monitoring. However, analysis of the data of the same clinical trial that led to the adoption of dabigatran in fixed-dosing regimens has indicated a small subgroup of patients that could be either over-treated, risking bleeding, or under-treated, risking embolism. Additional post-marketing data lends support to the favorable therapeutic profile of dabigatran but at the same time raises doubts about patient characteristics such as weight, age, renal function and their pharmacokinetic effects that, in some cases, could be serious enough to expose a minority of patients to risk. We will present a clinical case of a patient with an ischemic stroke while on dabigatran that was found with low dabigatran plasma levels and we will discuss the currently available data on the effects of inherent patient characteristics on dabigatran pharmacokinetics, the clinical impact of dabigatran plasma levels on safety and efficacy as well as the possibility of improving the risk–benefit profile of this agent by tailoring the dose for selected patient groups. PMID:26600870

  8. Age at menarche and digit ratio (2D:4D): relationships with body dissatisfaction, drive for thinness, and bulimia symptoms in women.

    PubMed

    Oinonen, Kirsten A; Bird, Jessica L

    2012-03-01

    This study examined the hypothesis that lower prenatal androgen exposure and earlier puberty are associated with more dysfunctional eating attitudes and behaviors. Relationships between both age at menarche (AAM) and 2D:4D (a marker of prenatal androgen exposure), and EDI-2-Body Dissatisfaction, EDI-2-Drive for Thinness, and EDI-2-Bulimia scores, were examined in women using correlations and regressions. Earlier menarche was associated with higher drive for thinness after controlling for BMI and negative affect, but only in women who were not exclusively heterosexual. Higher 2D:4D was associated with higher Bulimia and Body Dissatisfaction scores, but only in exclusively heterosexual women, and relationships disappeared when covariates were controlled. Later AAM and higher 2D:4D were unique predictors of higher Bulimia scores for exclusive heterosexuals when BMI was controlled. These findings suggest future research should examine sexual orientation as a mediator or moderator of prenatal and postnatal organizational hormonal effects on women's disordered eating attitudes and behaviors.

  9. Hazard function theory for nonstationary natural hazards

    NASA Astrophysics Data System (ADS)

    Read, L.; Vogel, R. M.

    2015-12-01

    Studies from the natural hazards literature indicate that many natural processes, including wind speeds, landslides, wildfires, precipitation, streamflow and earthquakes, show evidence of nonstationary behavior such as trends in magnitudes through time. Traditional probabilistic analysis of natural hazards based on partial duration series (PDS) generally assumes stationarity in the magnitudes and arrivals of events, i.e. that the probability of exceedance is constant through time. Given evidence of trends and the consequent expected growth in devastating impacts from natural hazards across the world, new methods are needed to characterize their probabilistic behavior. The field of hazard function analysis (HFA) is ideally suited to this problem because its primary goal is to describe changes in the exceedance probability of an event over time. HFA is widely used in medicine, manufacturing, actuarial statistics, reliability engineering, economics, and elsewhere. HFA provides a rich theory to relate the natural hazard event series (x) with its failure time series (t), enabling computation of corresponding average return periods and reliabilities associated with nonstationary event series. This work investigates the suitability of HFA to characterize nonstationary natural hazards whose PDS magnitudes are assumed to follow the widely applied Poisson-GP model. We derive a 2-parameter Generalized Pareto hazard model and demonstrate how metrics such as reliability and average return period are impacted by nonstationarity and discuss the implications for planning and design. Our theoretical analysis linking hazard event series x, with corresponding failure time series t, should have application to a wide class of natural hazards.

  10. Household Hazards to Pets

    MedlinePlus

    ... health by becoming aware of the most common health hazards found in many pet-owning households. Hazards in the Kitchen Foods Many foods are perfectly safe for humans, but could be harmful or potentially deadly to ...

  11. Deadly Cold: Health Hazards Due to Cold Weather. An Information Paper by the Subcommittee on Health and Long-Term Care of the Select Committee on Aging. House of Representatives, Ninety-Eighth Congress, Second Session (February 1984).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Select Committee on Aging.

    This paper, on the health hazards of cold weather for elderly persons, presents information from various sources on the death rates in winter throughout the United States. After reviewing the scope of the problem, specific health hazards associated with cold weather are discussed, i.e., hypothermia, fires, carbon monoxide poisoning, and influenza…

  12. Hazard function theory for nonstationary natural hazards

    NASA Astrophysics Data System (ADS)

    Read, L. K.; Vogel, R. M.

    2015-11-01

    Impact from natural hazards is a shared global problem that causes tremendous loss of life and property, economic cost, and damage to the environment. Increasingly, many natural processes show evidence of nonstationary behavior including wind speeds, landslides, wildfires, precipitation, streamflow, sea levels, and earthquakes. Traditional probabilistic analysis of natural hazards based on peaks over threshold (POT) generally assumes stationarity in the magnitudes and arrivals of events, i.e. that the probability of exceedance of some critical event is constant through time. Given increasing evidence of trends in natural hazards, new methods are needed to characterize their probabilistic behavior. The well-developed field of hazard function analysis (HFA) is ideally suited to this problem because its primary goal is to describe changes in the exceedance probability of an event over time. HFA is widely used in medicine, manufacturing, actuarial statistics, reliability engineering, economics, and elsewhere. HFA provides a rich theory to relate the natural hazard event series (X) with its failure time series (T), enabling computation of corresponding average return periods, risk and reliabilities associated with nonstationary event series. This work investigates the suitability of HFA to characterize nonstationary natural hazards whose POT magnitudes are assumed to follow the widely applied Generalized Pareto (GP) model. We derive the hazard function for this case and demonstrate how metrics such as reliability and average return period are impacted by nonstationarity and discuss the implications for planning and design. Our theoretical analysis linking hazard event series X, with corresponding failure time series T, should have application to a wide class of natural hazards with rich opportunities for future extensions.

  13. Hazard function theory for nonstationary natural hazards

    NASA Astrophysics Data System (ADS)

    Read, Laura K.; Vogel, Richard M.

    2016-04-01

    Impact from natural hazards is a shared global problem that causes tremendous loss of life and property, economic cost, and damage to the environment. Increasingly, many natural processes show evidence of nonstationary behavior including wind speeds, landslides, wildfires, precipitation, streamflow, sea levels, and earthquakes. Traditional probabilistic analysis of natural hazards based on peaks over threshold (POT) generally assumes stationarity in the magnitudes and arrivals of events, i.e., that the probability of exceedance of some critical event is constant through time. Given increasing evidence of trends in natural hazards, new methods are needed to characterize their probabilistic behavior. The well-developed field of hazard function analysis (HFA) is ideally suited to this problem because its primary goal is to describe changes in the exceedance probability of an event over time. HFA is widely used in medicine, manufacturing, actuarial statistics, reliability engineering, economics, and elsewhere. HFA provides a rich theory to relate the natural hazard event series (X) with its failure time series (T), enabling computation of corresponding average return periods, risk, and reliabilities associated with nonstationary event series. This work investigates the suitability of HFA to characterize nonstationary natural hazards whose POT magnitudes are assumed to follow the widely applied generalized Pareto model. We derive the hazard function for this case and demonstrate how metrics such as reliability and average return period are impacted by nonstationarity and discuss the implications for planning and design. Our theoretical analysis linking hazard random variable X with corresponding failure time series T should have application to a wide class of natural hazards with opportunities for future extensions.

  14. Hazard function theory for nonstationary natural hazards

    DOE PAGES

    Read, Laura K.; Vogel, Richard M.

    2016-04-11

    Impact from natural hazards is a shared global problem that causes tremendous loss of life and property, economic cost, and damage to the environment. Increasingly, many natural processes show evidence of nonstationary behavior including wind speeds, landslides, wildfires, precipitation, streamflow, sea levels, and earthquakes. Traditional probabilistic analysis of natural hazards based on peaks over threshold (POT) generally assumes stationarity in the magnitudes and arrivals of events, i.e., that the probability of exceedance of some critical event is constant through time. Given increasing evidence of trends in natural hazards, new methods are needed to characterize their probabilistic behavior. The well-developed field ofmore » hazard function analysis (HFA) is ideally suited to this problem because its primary goal is to describe changes in the exceedance probability of an event over time. HFA is widely used in medicine, manufacturing, actuarial statistics, reliability engineering, economics, and elsewhere. HFA provides a rich theory to relate the natural hazard event series (X) with its failure time series (T), enabling computation of corresponding average return periods, risk, and reliabilities associated with nonstationary event series. This work investigates the suitability of HFA to characterize nonstationary natural hazards whose POT magnitudes are assumed to follow the widely applied generalized Pareto model. We derive the hazard function for this case and demonstrate how metrics such as reliability and average return period are impacted by nonstationarity and discuss the implications for planning and design. As a result, our theoretical analysis linking hazard random variable X with corresponding failure time series T should have application to a wide class of natural hazards with opportunities for future extensions.« less

  15. Hazardous Waste Roundup

    ERIC Educational Resources Information Center

    Farenga, Stephen J.; Joyce, Beverly A.; Ness, Daniel

    2004-01-01

    According to the Environmental Protection Agency (EPA), Americans generate approximately 1.6 million tons of hazardous household waste every year. When most people think of hazardous waste, they generally think of materials used in construction, the defense industry, mining, manufacturing, and agriculture. Few people think of hazardous substances…

  16. Effect of the ratio of dietary n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid on broiler breeder performance, egg quality, and yolk fatty acid composition at different breeder ages.

    PubMed

    Koppenol, A; Delezie, E; Aerts, J; Willems, E; Wang, Y; Franssens, L; Everaert, N; Buyse, J

    2014-03-01

    When added to the feed of broiler breeder hens, dietary polyunsaturated fatty acids (FA) can be incorporated into the yolk and therefore become available to the progeny during their early development. The mechanism involved in lipid metabolism and deposition in the egg may be influenced by breeder age. Before the effect of an elevated concentration of certain polyunsaturated FA on the embryo can be investigated, the effect at breeder level and egg quality must be further assessed. The aim of the present experiment was to evaluate the effects of dietary n-6/n-3 ratios and dietary eicosapentaenoic acid (EPA, 20:5 n-3) and docosahexaenoic acid (DHA, 22:6 n-3) ratios, provided to broiler breeder hens, in terms of their zoo technical performance, egg quality, and yolk FA composition. Starting at 6 wk of age, 640 Ross-308 broiler breeder hens were fed 1 of 4 different diets. The control diet was a basal diet, rich in n-6 FA. The 3 other diets were enriched in n-3 FA, formulated to obtain a different EPA/DHA ratio of 1/1 (EPA = DHA), 1/2 (DHA), or 2/1 (EPA). In fact, after analysis the EPA/DHA ratio was 0.8, 0.4, or 2.1, respectively. Dietary EPA and DHA addition did not affect the performance of the breeder hens, except for egg weight. Egg weight was lower (P < 0.001) for all n-3 treatments. Dietary EPA improved number of eggs laid in the first 2 wk of the production cycle (P = 0.029). The absolute and relative yolk weight of eggs laid by EPA = DHA fed hens was lowest (P = 0.004 and P = 0.025, respectively). The EPA and DHA concentrations in the yolk were highly dependent on dietary EPA and DHA concentrations with a regression coefficient equal to 0.89. It can be concluded that dietary EPA and DHA can be incorporated in the breeder egg yolk to become available for the developing embryo, without compromising the performance and egg quality of the flock.

  17. Hazard perception in emergency medical service responders.

    PubMed

    Johnston, K A; Scialfa, C T

    2016-10-01

    The perception of on-road hazards is critically important to emergency medical services (EMS) professionals, the patients they transport and the general public. This study compared hazard perception in EMS and civilian drivers of similar age and personal driving experience. Twenty-nine EMS professionals and 24 non-professional drivers were given a dynamic hazard perception test (HPT). The EMS group demonstrated an advantage in HPT that was independent of simple reaction time, another indication of the validity of the test. These results are also consistent with the view that professional driving experience results in changes in the ability to identify and respond to on-road hazards. Directions for future research include the development of a profession-specific hazard perception tool for both assessment and training purposes.

  18. Hazard perception in emergency medical service responders.

    PubMed

    Johnston, K A; Scialfa, C T

    2016-10-01

    The perception of on-road hazards is critically important to emergency medical services (EMS) professionals, the patients they transport and the general public. This study compared hazard perception in EMS and civilian drivers of similar age and personal driving experience. Twenty-nine EMS professionals and 24 non-professional drivers were given a dynamic hazard perception test (HPT). The EMS group demonstrated an advantage in HPT that was independent of simple reaction time, another indication of the validity of the test. These results are also consistent with the view that professional driving experience results in changes in the ability to identify and respond to on-road hazards. Directions for future research include the development of a profession-specific hazard perception tool for both assessment and training purposes. PMID:27415813

  19. Automated Hazard Analysis

    2003-06-26

    The Automated Hazard Analysis (AHA) application is a software tool used to conduct job hazard screening and analysis of tasks to be performed in Savannah River Site facilities. The AHA application provides a systematic approach to the assessment of safety and environmental hazards associated with specific tasks, and the identification of controls regulations, and other requirements needed to perform those tasks safely. AHA is to be integrated into existing Savannah River site work control andmore » job hazard analysis processes. Utilization of AHA will improve the consistency and completeness of hazard screening and analysis, and increase the effectiveness of the work planning process.« less

  20. Hazard Analysis Database Report

    SciTech Connect

    GRAMS, W.H.

    2000-12-28

    The Hazard Analysis Database was developed in conjunction with the hazard analysis activities conducted in accordance with DOE-STD-3009-94, Preparation Guide for U S . Department of Energy Nonreactor Nuclear Facility Safety Analysis Reports, for HNF-SD-WM-SAR-067, Tank Farms Final Safety Analysis Report (FSAR). The FSAR is part of the approved Authorization Basis (AB) for the River Protection Project (RPP). This document describes, identifies, and defines the contents and structure of the Tank Farms FSAR Hazard Analysis Database and documents the configuration control changes made to the database. The Hazard Analysis Database contains the collection of information generated during the initial hazard evaluations and the subsequent hazard and accident analysis activities. The Hazard Analysis Database supports the preparation of Chapters 3 ,4 , and 5 of the Tank Farms FSAR and the Unreviewed Safety Question (USQ) process and consists of two major, interrelated data sets: (1) Hazard Analysis Database: Data from the results of the hazard evaluations, and (2) Hazard Topography Database: Data from the system familiarization and hazard identification.

  1. Hazard Analysis Database Report

    SciTech Connect

    GAULT, G.W.

    1999-10-13

    The Hazard Analysis Database was developed in conjunction with the hazard analysis activities conducted in accordance with DOE-STD-3009-94, Preparation Guide for US Department of Energy Nonreactor Nuclear Facility Safety Analysis Reports, for the Tank Waste Remediation System (TWRS) Final Safety Analysis Report (FSAR). The FSAR is part of the approved TWRS Authorization Basis (AB). This document describes, identifies, and defines the contents and structure of the TWRS FSAR Hazard Analysis Database and documents the configuration control changes made to the database. The TWRS Hazard Analysis Database contains the collection of information generated during the initial hazard evaluations and the subsequent hazard and accident analysis activities. The database supports the preparation of Chapters 3,4, and 5 of the TWRS FSAR and the USQ process and consists of two major, interrelated data sets: (1) Hazard Evaluation Database--Data from the results of the hazard evaluations; and (2) Hazard Topography Database--Data from the system familiarization and hazard identification.

  2. The Integrated Hazard Analysis Integrator

    NASA Technical Reports Server (NTRS)

    Morris, A. Terry; Massie, Michael J.

    2009-01-01

    Hazard analysis addresses hazards that arise in the design, development, manufacturing, construction, facilities, transportation, operations and disposal activities associated with hardware, software, maintenance, operations and environments. An integrated hazard is an event or condition that is caused by or controlled by multiple systems, elements, or subsystems. Integrated hazard analysis (IHA) is especially daunting and ambitious for large, complex systems such as NASA s Constellation program which incorporates program, systems and element components that impact others (International Space Station, public, International Partners, etc.). An appropriate IHA should identify all hazards, causes, controls and verifications used to mitigate the risk of catastrophic loss of crew, vehicle and/or mission. Unfortunately, in the current age of increased technology dependence, there is the tendency to sometimes overlook the necessary and sufficient qualifications of the integrator, that is, the person/team that identifies the parts, analyzes the architectural structure, aligns the analysis with the program plan and then communicates/coordinates with large and small components, each contributing necessary hardware, software and/or information to prevent catastrophic loss. As viewed from both Challenger and Columbia accidents, lack of appropriate communication, management errors and lack of resources dedicated to safety were cited as major contributors to these fatalities. From the accident reports, it would appear that the organizational impact of managers, integrators and safety personnel contributes more significantly to mission success and mission failure than purely technological components. If this is so, then organizations who sincerely desire mission success must put as much effort in selecting managers and integrators as they do when designing the hardware, writing the software code and analyzing competitive proposals. This paper will discuss the necessary and

  3. Migration and Environmental Hazards

    PubMed Central

    Hunter, Lori M.

    2011-01-01

    Losses due to natural hazards (e.g., earthquakes, hurricanes) and technological hazards (e.g., nuclear waste facilities, chemical spills) are both on the rise. One response to hazard-related losses is migration, with this paper offering a review of research examining the association between migration and environmental hazards. Using examples from both developed and developing regional contexts, the overview demonstrates that the association between migration and environmental hazards varies by setting, hazard types, and household characteristics. In many cases, however, results demonstrate that environmental factors play a role in shaping migration decisions, particularly among those most vulnerable. Research also suggests that risk perception acts as a mediating factor. Classic migration theory is reviewed to offer a foundation for examination of these associations. PMID:21886366

  4. Software safety hazard analysis

    SciTech Connect

    Lawrence, J.D.

    1996-02-01

    Techniques for analyzing the safety and reliability of analog-based electronic protection systems that serve to mitigate hazards in process control systems have been developed over many years, and are reasonably well understood. An example is the protection system in a nuclear power plant. The extension of these techniques to systems which include digital computers is not well developed, and there is little consensus among software engineering experts and safety experts on how to analyze such systems. One possible technique is to extend hazard analysis to include digital computer-based systems. Software is frequently overlooked during system hazard analyses, but this is unacceptable when the software is in control of a potentially hazardous operation. In such cases, hazard analysis should be extended to fully cover the software. A method for performing software hazard analysis is proposed in this paper.

  5. Hazard baseline documentation

    SciTech Connect

    Not Available

    1994-08-01

    This DOE limited technical standard establishes uniform Office of Environmental Management (EM) guidance on hazards baseline documents that identify and control radiological and nonradiological hazards for all EM facilities. It provides a road map to the safety and health hazard identification and control requirements contained in the Department`s orders and provides EM guidance on the applicability and integration of these requirements. This includes a definition of four classes of facilities (nuclear, non-nuclear, radiological, and other industrial); the thresholds for facility hazard classification; and applicable safety and health hazard identification, controls, and documentation. The standard applies to the classification, development, review, and approval of hazard identification and control documentation for EM facilities.

  6. Migration and Environmental Hazards.

    PubMed

    Hunter, Lori M

    2005-03-01

    Losses due to natural hazards (e.g., earthquakes, hurricanes) and technological hazards (e.g., nuclear waste facilities, chemical spills) are both on the rise. One response to hazard-related losses is migration, with this paper offering a review of research examining the association between migration and environmental hazards. Using examples from both developed and developing regional contexts, the overview demonstrates that the association between migration and environmental hazards varies by setting, hazard types, and household characteristics. In many cases, however, results demonstrate that environmental factors play a role in shaping migration decisions, particularly among those most vulnerable. Research also suggests that risk perception acts as a mediating factor. Classic migration theory is reviewed to offer a foundation for examination of these associations.

  7. Volcano Hazards Program

    USGS Publications Warehouse

    Venezky, Dina Y.; Myers, Bobbie; Driedger, Carolyn

    2008-01-01

    Diagram of common volcano hazards. The U.S. Geological Survey Volcano Hazards Program (VHP) monitors unrest and eruptions at U.S. volcanoes, assesses potential hazards, responds to volcanic crises, and conducts research on how volcanoes work. When conditions change at a monitored volcano, the VHP issues public advisories and warnings to alert emergency-management authorities and the public. See http://volcanoes.usgs.gov/ to learn more about volcanoes and find out what's happening now.

  8. Hazardous waste tracking issues

    SciTech Connect

    Marvin, R. )

    1993-08-01

    The concept of cradle-to-grave oversight of hazardous waste was established in 1976 under RCRA. Since then, the multicopy Uniform Hazardous Waste Manifest has been a key component in the federal tracking system. The manifests ensure that generators, transporters and TSDFs maintain documentation of hazardous waste shipments. To a large extent, the tracking system has served its intended purpose; nevertheless, certain shortcomings exist. Anyone involved in shipping hazardous waste should be aware of the system's weaknesses and take appropriate measures to compensate for them.

  9. [Clinical research XXII. From clinical judgment to Cox proportional hazards model].

    PubMed

    Pérez-Rodríguez, Marcela; Rivas-Ruiz, Rodolfo; Palacios-Cruz, Lino; Talavera, Juan O

    2014-01-01

    Survival analyses are commonly used to determine the time of an event (for example, death). However, they can be used also for other clinical outcomes on the condition that these are dichotomous, for example healing time. These analyses only consider the relationship of one variable. However, Cox proportional hazards model is a multivariate analysis of the survival analysis, in which other potentially confounding covariates of the effect of the main maneuver studied, such as age, gender or disease stage, are taken into account. This analysis can include both quantitative and qualitative variables in the model. The measure of association used is called hazard ratio (HR) or relative risk ratio, which is not the same as the relative risk or odds ratio (OR). The difference is that the HR refers to the possibility that one of the groups develops the event before it is compared with the other group. The proportional hazards multivariate model of Cox is the most widely used in medicine when the phenomenon is studied in two dimensions: time and event.

  10. A Windshear Hazard Index

    NASA Technical Reports Server (NTRS)

    Proctor, Fred H.; Hinton, David A.; Bowles, Roland L.

    2000-01-01

    An aircraft exposed to hazardous low-level windshear may suffer a critical loss of airspeed and altitude, thus endangering its ability to remain airborne. In order to characterize this hazard, a nondimensional index was developed based oil aerodynamic principals and understanding of windshear phenomena, 'This paper reviews the development and application of the Bowles F-tactor. which is now used by onboard sensors for the detection of hazardous windshear. It was developed and tested during NASA/I:AA's airborne windshear program and is now required for FAA certification of onboard radar windshear detection systems. Reviewed in this paper are: 1) definition of windshear and description of atmospheric phenomena that may cause hazardous windshear. 2) derivation and discussion of the F-factor. 3) development of the F-factor hazard threshold, 4) its testing during field deployments, and 5) its use in accident reconstructions,

  11. Natural hazards science strategy

    USGS Publications Warehouse

    Holmes, Jr., Robert R.; Jones, Lucile M.; Eidenshink, Jeffery C.; Godt, Jonathan W.; Kirby, Stephen H.; Love, Jeffrey J.; Neal, Christina A.; Plant, Nathaniel G.; Plunkett, Michael L.; Weaver, Craig S.; Wein, Anne; Perry, Suzanne C.

    2012-01-01

    The mission of the U.S. Geological Survey (USGS) in natural hazards is to develop and apply hazard science to help protect the safety, security, and economic well-being of the Nation. The costs and consequences of natural hazards can be enormous, and each year more people and infrastructure are at risk. USGS scientific research - founded on detailed observations and improved understanding of the responsible physical processes - can help to understand and reduce natural hazard risks and to make and effectively communicate reliable statements about hazard characteristics, such as frequency, magnitude, extent, onset, consequences, and where possible, the time of future events. To accomplish its broad hazard mission, the USGS maintains an expert workforce of scientists and technicians in the earth sciences, hydrology, biology, geography, social and behavioral sciences, and other fields, and engages cooperatively with numerous agencies, research institutions, and organizations in the public and private sectors, across the Nation and around the world. The scientific expertise required to accomplish the USGS mission in natural hazards includes a wide range of disciplines that this report refers to, in aggregate, as hazard science. In October 2010, the Natural Hazards Science Strategy Planning Team (H-SSPT) was charged with developing a long-term (10-year) Science Strategy for the USGS mission in natural hazards. This report fulfills that charge, with a document hereinafter referred to as the Strategy, to provide scientific observations, analyses, and research that are critical for the Nation to become more resilient to natural hazards. Science provides the information that decisionmakers need to determine whether risk management activities are worthwhile. Moreover, as the agency with the perspective of geologic time, the USGS is uniquely positioned to extend the collective experience of society to prepare for events outside current memory. The USGS has critical statutory

  12. Hazard potential ranking of hazardous waste landfill sites and risk of congenital anomalies

    PubMed Central

    Vrijheid, M; Dolk, H; Armstrong, B; Boschi, G; Busby, A; Jorgensen, T; Pointer, P

    2002-01-01

    Background: A 33% increase in the risk of congenital anomalies has been found among residents near hazardous waste landfill sites in a European collaborative study (EUROHAZCON). Aims: To develop and evaluate an expert panel scoring method of the hazard potential of EUROHAZCON landfill sites, and to investigate whether sites classified as posing a greater potential hazard are those with a greater risk of congenital anomaly among nearby residents relative to more distant residents. Methods: A total of 1270 cases of congenital anomaly and 2308 non-malformed control births were selected in 14 study areas around 20 landfill sites. An expert panel of four landfill specialists scored each site in three categories—overall, water, and air hazard—based on readily available, documented data on site characteristics. Tertiles of the average ranking scores defined low, medium, and high hazard sites. Calculation of odds ratios was based on distance of residence from the sites, comparing a 0–3 km "proximate" with a 3–7 km "distant" zone. Results: Agreement between experts measured by intraclass correlation coefficients was 0.50, 0.44, and 0.20 for overall, water, and air hazard before a consensus meeting and 0.60, 0.56, and 0.53 respectively after this meeting. There was no evidence for a trend of increasing odds ratios with increasing overall hazard or air hazard. For non-chromosomal anomalies, odds ratios by water hazard category showed an increasing trend of borderline statistical significance (p = 0.06) from 0.79 in the low hazard category, 1.43 in the medium, to 1.60 in the high water hazard category. Conclusions: There is little evidence for a relation between risk of congenital anomaly in proximate relative to distant zones and hazard potential of landfill sites as classified by the expert panel, but without external validation of the hazard potential scoring method interpretation is difficult. Potential misclassification of sites may have reduced our ability to

  13. Elimination of the hazards from hazardous wastes.

    PubMed Central

    Gloyna, E F; Taylor, R D

    1978-01-01

    The "hazard" associated with a waste essentially controls the overall engineering approach to finding suitable alternatives for solving potential disposal problems. It should be recognized that all factors affecting environmental equilibrium must be considered, including product sales, process design, financing, pre- and end-of-pipe treatment, residuals management, and ultimate bioaccumulation of residuals. To meet this challenge, a systems approach to waste treatment and residuals disposal provides a logical approach, but this management concept requires a thorough understanding of the important physical and chemical aspects of the problem, as well as many social implications of the resulting decisions. Thus waste management within a plant necessarily involves process control, pretreatment and end-of-pipe treatment. Further, it follows that residuals management from a disposal point-of-view must ultimately embrace what is called the "multi-barrier concept." In essence, hazard elimination occurs in varying degrees during each phase of a properly engineered system. PMID:738249

  14. Probabilistic Seismic Hazard Analysis

    SciTech Connect

    Not Available

    1988-01-01

    The purpose of Probabilistic Seismic Hazard Analysis (PSHA) is to evaluate the hazard of seismic ground motion at a site by considering all possible earthquakes in the area, estimating the associated shaking at the site, and calculating the probabilities of these occurrences. The Panel on Seismic Hazard Analysis is charged with assessment of the capabilities, limitations, and future trends of PSHA in the context of alternatives. The report identifies and discusses key issues of PSHA and is addressed to decision makers with a modest scientific and technical background and to the scientific and technical community. 37 refs., 19 figs.

  15. Hazardous substance liability insurance

    SciTech Connect

    Not Available

    1982-03-01

    The study was carried out to meet requirements of the Comprehensive Environmental Response, Compensation and Liability Act of 1980. It considers the adequacy and feasibility of private insurance to protect owners and operators of ships covered by the Act and for post-closure financial responsibility for hazardous waste disposal facilities. The report is in three parts: Pt. 1 is an introduction to the hazardous substance insurance problem; Pt. 2 considers the adequacy of private insurance for owners and operators of vessels and facilities; Pt. 3 focuses on the problem of a private insurance alternative to the Post-Closure Liability Fund for 'inactive' hazardous waste disposal facilities.

  16. Parametric Hazard Function Estimation.

    1999-09-13

    Version 00 Phaze performs statistical inference calculations on a hazard function (also called a failure rate or intensity function) based on reported failure times of components that are repaired and restored to service. Three parametric models are allowed: the exponential, linear, and Weibull hazard models. The inference includes estimation (maximum likelihood estimators and confidence regions) of the parameters and of the hazard function itself, testing of hypotheses such as increasing failure rate, and checking ofmore » the model assumptions.« less

  17. Space Debris Hazard Evaluation

    NASA Technical Reports Server (NTRS)

    Davison, Elmer H.; Winslow, Paul C., Jr.

    1961-01-01

    The hazard to space vehicles from natural space debris has been explored. A survey of the available information pertinent to this problem is presented. The hope is that this presentation gives a coherent picture of the knowledge to date in terms of the topic covered. The conclusion reached is that a definite hazard exists but that it can only be poorly assessed on the basis of present information. The need for direct measurement of this hazard is obvious, and some of the problems involved in making these direct measurements have been explored.

  18. Environmentally Related Health Hazards in the Schools.

    ERIC Educational Resources Information Center

    Andrews, James B.; Neuroth, Richard

    The quality of air inside the schoolhouses of America may have a profound effect on students' ability to concentrate on their lessons. The environmental hazards that influence the quality of the indoor air (IAQ) of our schools have not been well understood. Research evidence suggests that school age children and youth (especially those under the…

  19. Hazardous waste landfill leachate characteristics

    SciTech Connect

    Pavelka, C. ); Loehr, R.C. . Environmental and Water Resources Engineering Program); Haikola, B. )

    1993-01-01

    Leachate data from 18 commercial hazardous waste landfills or cells were evaluated to determine overall leachate characteristics and parameters that may affect leachate generation and characteristics. The landfills studied have a wide range of practices, none of which are necessarily representative of the most current landfill design, operating or closure practice in the United States. The leachate samples were from landfills that represented varying waste types, waste age, geographic locations and climate. The parameters evaluated included chemical properties, co-disposal of hazardous and municipal solid wastes, climatic conditions, and waste age in the landfills. The leachate samples had been analyzed for 62 volatiles, 107 semi-volatiles, 16 metals, 28 pesticides, herbicides and insecticides, and 17 other chemicals. The results indicate that: (a) the organics in the leachate with high concentrations had high solubilities and low octanol-water coefficients, (b) landfills in arid climates produced less leachate than those in temperate and sub-tropical climates, and (c) leachate production appeared to be related to use of a cap or cover.

  20. Barrier Island Hazard Mapping.

    ERIC Educational Resources Information Center

    Pilkey, Orrin H.; Neal, William J.

    1980-01-01

    Describes efforts to evaluate and map the susceptibility of barrier islands to damage from storms, erosion, rising sea levels and other natural phenomena. Presented are criteria for assessing the safety and hazard potential of island developments. (WB)

  1. Automated Standard Hazard Tool

    NASA Technical Reports Server (NTRS)

    Stebler, Shane

    2014-01-01

    The current system used to generate standard hazard reports is considered cumbersome and iterative. This study defines a structure for this system's process in a clear, algorithmic way so that standard hazard reports and basic hazard analysis may be completed using a centralized, web-based computer application. To accomplish this task, a test server is used to host a prototype of the tool during development. The prototype is configured to easily integrate into NASA's current server systems with minimal alteration. Additionally, the tool is easily updated and provides NASA with a system that may grow to accommodate future requirements and possibly, different applications. Results of this project's success are outlined in positive, subjective reviews complete by payload providers and NASA Safety and Mission Assurance personnel. Ideally, this prototype will increase interest in the concept of standard hazard automation and lead to the full-scale production of a user-ready application.

  2. California's potential volcanic hazards

    SciTech Connect

    Jorgenson, P. )

    1989-01-01

    Although volcanic eruptions have occurred infrequently in California during the last few thousand years, the potential danger to life and property from volcanoes in the state is great enough to be of concern, according to a recent U.S. Geological Survey (USGS) publication. The 17-page bulletin, Potential Hazards from Future Volcanic Eruptions in California, gives a brief history of volcanic activity in California during the past 100,000 years, descriptions of the types of volcanoes in the state, the types of potentially hazardous volcanic events that could occur, and hazard-zonation maps and tables depicting six areas of the state where volcanic eruptions might occur. The six areas and brief descriptions of their past volcanic history and potential for future volcanic hazards are briefly summarized here.

  3. Hazardous material control

    SciTech Connect

    Not Available

    1990-01-01

    This book covers the following topics. Waste exchange and recycling, the New York State experience. Department of defense hazardous waste minimazation, Recovery of heavy metals from electric arc furnace steelmaking dusts, Small generator cooperative effects economical recycling.

  4. Health Care Wide Hazards

    MedlinePlus

    ... Employee Downloads Additional Information Latex Allergy Legionnaires' Disease Mercury Needlesticks Noise Other Hazards (Lack of) PPE Slips/ ... Staphylococcus aureus Latex Allergy Legionnaires' Disease Needlesticks Noise Mercury Inappropriate PPE Slips/Trips/Falls Stress Tuberculosis Lack ...

  5. Developing hazardous waste programs

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    Developing a fully operational hazardous waste regulatory system requires at least 10 to 15 years—even in countries with strong legal and bureaucratic institutions, according to a report on "The Evolution of Hazardous Waste Programs," which was funded by Resources for the Future (RFF) and the World Bank's South Asia Environment Group, and issued on June 4.The report, which compares the experiences of how four developed and four developing countries have created hazardous waste programs, indicates that hazardous waste issues usually do not become a pressing environmental issue until after countries have dealt with more direct threats to public health, such as contaminated drinking water and air pollution. The countries examined include Indonesia, Thailand, Germany, and the United States.

  6. Probabilistic Tsunami Hazard Analysis

    NASA Astrophysics Data System (ADS)

    Thio, H. K.; Ichinose, G. A.; Somerville, P. G.; Polet, J.

    2006-12-01

    The recent tsunami disaster caused by the 2004 Sumatra-Andaman earthquake has focused our attention to the hazard posed by large earthquakes that occur under water, in particular subduction zone earthquakes, and the tsunamis that they generate. Even though these kinds of events are rare, the very large loss of life and material destruction caused by this earthquake warrant a significant effort towards the mitigation of the tsunami hazard. For ground motion hazard, Probabilistic Seismic Hazard Analysis (PSHA) has become a standard practice in the evaluation and mitigation of seismic hazard to populations in particular with respect to structures, infrastructure and lifelines. Its ability to condense the complexities and variability of seismic activity into a manageable set of parameters greatly facilitates the design of effective seismic resistant buildings but also the planning of infrastructure projects. Probabilistic Tsunami Hazard Analysis (PTHA) achieves the same goal for hazards posed by tsunami. There are great advantages of implementing such a method to evaluate the total risk (seismic and tsunami) to coastal communities. The method that we have developed is based on the traditional PSHA and therefore completely consistent with standard seismic practice. Because of the strong dependence of tsunami wave heights on bathymetry, we use a full waveform tsunami waveform computation in lieu of attenuation relations that are common in PSHA. By pre-computing and storing the tsunami waveforms at points along the coast generated for sets of subfaults that comprise larger earthquake faults, we can efficiently synthesize tsunami waveforms for any slip distribution on those faults by summing the individual subfault tsunami waveforms (weighted by their slip). This efficiency make it feasible to use Green's function summation in lieu of attenuation relations to provide very accurate estimates of tsunami height for probabilistic calculations, where one typically computes

  7. K Basin Hazard Analysis

    SciTech Connect

    PECH, S.H.

    2000-08-23

    This report describes the methodology used in conducting the K Basins Hazard Analysis, which provides the foundation for the K Basins Final Safety Analysis Report. This hazard analysis was performed in accordance with guidance provided by DOE-STD-3009-94, Preparation Guide for U. S. Department of Energy Nonreactor Nuclear Facility Safety Analysis Reports and implements the requirements of DOE Order 5480.23, Nuclear Safety Analysis Report.

  8. K Basins Hazard Analysis

    SciTech Connect

    WEBB, R.H.

    1999-12-29

    This report describes the methodology used in conducting the K Basins Hazard Analysis, which provides the foundation for the K Basins Safety Analysis Report (HNF-SD-WM-SAR-062, Rev.4). This hazard analysis was performed in accordance with guidance provided by DOE-STD-3009-94, Preparation Guide for U. S. Department of Energy Nonreactor Nuclear Facility Safety Analysis Reports and implements the requirements of DOE Order 5480.23, Nuclear Safety Analysis Report.

  9. Geomorphology and natural hazards

    NASA Astrophysics Data System (ADS)

    Gares, Paul A.; Sherman, Douglas J.; Nordstrom, Karl F.

    1994-08-01

    Natural hazards research was initiated in the 1960's by Gilbert White and his students who promulgated a research paradigm that involved assessing risk from a natural event, identifying adjustments to cope with the hazard, determining people's perception of the event, defining the process by which people choose adjustments, and estimating the effects of public policy on the choice process. Studies of the physical system played an important role in early research, but criticismsof the paradigm resulted in a shift to a prominence of social science. Geomorphologists are working to fill gaps in knowledge of the physical aspects of individual hazards, but use of the information by social scientists will only occur if information is presented in a format that is useful to them. One format involves identifying the hazard according to seven physical parameters established by White and his colleagues: magnitude, frequency, duration, areal extent, speed of onset, spatial dispersion, and temporal spacing. Geomorphic hazards are regarded as related to landscape changes that affect human systems. The processes that produce the changes are rarely geomorphic in nature, but are better regarded as atmospheric or hydrologic. An examination of geomorphic hazards in four fields — soil erosion, mass movement, coastal erosion and fluvial erosion — demonstrates that advances in those fields may be evaluated in terms of the seven parameters. Geomorphologists have contributed to hazard research by focusing on the dynamics of the landforms. The prediction of occurence, the determination of spatial and temporal characteristics, the impact of physical characteristics on people's perception, and the impact of physical characteristics on adjustment formulation. Opportunities for geomorphologists to improve our understanding of geomorphic hazards include research into the characteristics of the events particularly with respect to predicting the occurence, and increased evaluation of the

  10. Transportation of Hazardous Materials Emergency Preparedness Hazards Assessment

    SciTech Connect

    Blanchard, A.

    2000-02-28

    This report documents the Emergency Preparedness Hazards Assessment (EPHA) for the Transportation of Hazardous Materials (THM) at the Department of Energy (DOE) Savannah River Site (SRS). This hazards assessment is intended to identify and analyze those transportation hazards significant enough to warrant consideration in the SRS Emergency Management Program.

  11. Wake-Vortex Hazards During Cruise

    NASA Technical Reports Server (NTRS)

    Rossow, Vernon J.; James, Kevin D.; Nixon, David (Technical Monitor)

    1998-01-01

    Even though the hazard posed by lift-generated wakes of subsonic transport aircraft has been studied extensively for approach and departure at airports, only a small amount of effort has gone into the potential hazard at cruise altitude. This paper reports on a studio of the wake-vortex hazard during cruise because encounters may become more prevalent when free-flight becomes available and each aircraft, is free to choose its own route between destinations. In order to address the problem, the various fluid-dynamic stages that vortex wakes usually go through as they age will be described along with estimates of the potential hazard that each stage poses. It appears that a rolling-moment hazard can be just as severe at cruise as for approach at airports, but it only persists for several minutes. However, the hazard posed by the downwash in the wake due to the lift on the generator aircraft persists for tens of minutes in a long narrow region behind the generating aircraft. The hazard consists of severe vertical loads when an encountering aircraft crosses the wake. A technique for avoiding vortex wakes at cruise altitude will be described. To date the hazard posed by lift-generated vortex wakes and their persistence at cruise altitudes has been identified and subdivided into several tasks. Analyses of the loads to be encounter and are underway and should be completed shortly. A review of published literature on the subject has been nearly completed (see text) and photographs of vortex wakes at cruise altitudes have been taken and the various stages of decay have been identified. It remains to study and sort the photographs for those that best illustrate the various stages of decay after they are shed by subsonic transport aircraft at cruise altitudes. The present status of the analysis and the paper are described.

  12. Parity, age at first birth, and risk of death from asthma: evidence from a cohort in taiwan.

    PubMed

    Chen, Chih-Cheng; Chiu, Hui-Fen; Yang, Chun-Yuh

    2014-06-11

    This study was undertaken to examine whether there is an association between age at first birth and parity and risk of asthma death. The study cohort consisted of 1,292,462 women in Taiwan who had a first live birth between 1 January 1978 and 31 December 1987. We tracked each woman from the date of their first childbirth to 31 December 2009, and their vital status was ascertained by linking records with the computerized mortality database. Cox proportional hazard regression models were used to estimate hazard ratios of death from asthma associated with parity and age at first birth. A trend of increasing risk of asthma death was seen with increasing age at first birth. The adjusted hazard ratio was 0.75 (95% confidence interval (CI) = 0.53-1.08) among women with two live births and 0.53 (95% CI = 0.36-0.78) among those with three or more births, compared with women who had one live birth. There was a significant decreasing trend in adjusted hazard ratios of asthma death with increasing parity. This study is the first to provide evidences to support an association between reproductive factors (parity and early age at first birth) and the risk of asthma death.

  13. Two models for evaluating landslide hazards

    USGS Publications Warehouse

    Davis, J.C.; Chung, C.-J.; Ohlmacher, G.C.

    2006-01-01

    Two alternative procedures for estimating landslide hazards were evaluated using data on topographic digital elevation models (DEMs) and bedrock lithologies in an area adjacent to the Missouri River in Atchison County, Kansas, USA. The two procedures are based on the likelihood ratio model but utilize different assumptions. The empirical likelihood ratio model is based on non-parametric empirical univariate frequency distribution functions under an assumption of conditional independence while the multivariate logistic discriminant model assumes that likelihood ratios can be expressed in terms of logistic functions. The relative hazards of occurrence of landslides were estimated by an empirical likelihood ratio model and by multivariate logistic discriminant analysis. Predictor variables consisted of grids containing topographic elevations, slope angles, and slope aspects calculated from a 30-m DEM. An integer grid of coded bedrock lithologies taken from digitized geologic maps was also used as a predictor variable. Both statistical models yield relative estimates in the form of the proportion of total map area predicted to already contain or to be the site of future landslides. The stabilities of estimates were checked by cross-validation of results from random subsamples, using each of the two procedures. Cell-by-cell comparisons of hazard maps made by the two models show that the two sets of estimates are virtually identical. This suggests that the empirical likelihood ratio and the logistic discriminant analysis models are robust with respect to the conditional independent assumption and the logistic function assumption, respectively, and that either model can be used successfully to evaluate landslide hazards. ?? 2006.

  14. Diet, evolution and aging--the pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet.

    PubMed

    Frassetto, L; Morris, R C; Sellmeyer, D E; Todd, K; Sebastian, A

    2001-10-01

    , reduced bone resorption rates, improved nitrogen balance, and mitigated the normally occurring age-related decline in growth hormone secretion--all without restricting dietary NaCl. Moreover, we found that co-administration of an alkalinizing salt of potassium (potassium citrate) with NaCl prevented NaCl from increasing urinary calcium excretion and bone resorption, as occurred with NaCl administration alone. Earlier studies estimated dietary acid load from the amount of animal protein in the diet, inasmuch as protein metabolism yields sulfuric acid as an end-product. In cross-cultural epidemiologic studies, Abelow found that hip fracture incidence in older women correlated with animal protein intake, and they suggested a causal relation to the acid load from protein. Those studies did not consider the effect of potential sources of base in the diet. We considered that estimating the net acid load of the diet (i. e., acid minus base) would require considering also the intake of plant foods, many of which are rich sources of K-base, or more precisely base precursors, substances like organic anions that the body metabolizes to bicarbonate. In following up the findings of Abelow et al., we found that plant food intake tended to be protective against hip fracture, and that hip fracture incidence among countries correlated inversely with the ratio of plant-to-animal food intake. These findings were confirmed in a more homogeneous population of white elderly women residents of the U.S. These findings support affirmative answers to the questions we asked above. Can we provide dietary guidelines for controlling dietary net acid loads to minimize or eliminate diet-induced and age-amplified chronic low-grade metabolic acidosis and its pathophysiological sequelae. We discuss the use of algorithms to predict the diet net acid and provide nutritionists and clinicians with relatively simple and reliable methods for determining and controlling the net acid load of the diet. A more

  15. Chemical process hazards analysis

    SciTech Connect

    1996-02-01

    The Office of Worker Health and Safety (EH-5) under the Assistant Secretary for the Environment, Safety and Health of the US Department (DOE) has published two handbooks for use by DOE contractors managing facilities and processes covered by the Occupational Safety and Health Administration (OSHA) Rule for Process Safety Management of Highly Hazardous Chemicals (29 CFR 1910.119), herein referred to as the PSM Rule. The PSM Rule contains an integrated set of chemical process safety management elements designed to prevent chemical releases that can lead to catastrophic fires, explosions, or toxic exposures. The purpose of the two handbooks, ``Process Safety Management for Highly Hazardous Chemicals`` and ``Chemical Process Hazards Analysis,`` is to facilitate implementation of the provisions of the PSM Rule within the DOE. The purpose of this handbook ``Chemical Process Hazards Analysis,`` is to facilitate, within the DOE, the performance of chemical process hazards analyses (PrHAs) as required under the PSM Rule. It provides basic information for the performance of PrHAs, and should not be considered a complete resource on PrHA methods. Likewise, to determine if a facility is covered by the PSM rule, the reader should refer to the handbook, ``Process Safety Management for Highly Hazardous Chemicals`` (DOE- HDBK-1101-96). Promulgation of the PSM Rule has heightened the awareness of chemical safety management issues within the DOE. This handbook is intended for use by DOE facilities and processes covered by the PSM rule to facilitate contractor implementation of the PrHA element of the PSM Rule. However, contractors whose facilities and processes not covered by the PSM Rule may also use this handbook as a basis for conducting process hazards analyses as part of their good management practices. This handbook explains the minimum requirements for PrHAs outlined in the PSM Rule. Nowhere have requirements been added beyond what is specifically required by the rule.

  16. Muscle Quality and Myosteatosis: Novel Associations With Mortality Risk: The Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study.

    PubMed

    Reinders, Ilse; Murphy, Rachel A; Brouwer, Ingeborg A; Visser, Marjolein; Launer, Lenore; Siggeirsdottir, Kristin; Eiriksdottir, Gudny; Gudnason, Vilmundur; Jonsson, Palmi V; Lang, Thomas F; Harris, Tamara B

    2016-01-01

    Muscle composition may affect mortality risk, but prior studies have been limited to specific samples or less precise determination of muscle composition. We evaluated associations of thigh muscle composition, determined using computed tomography imaging, and knee extension strength with mortality risk among 4,824 participants aged 76.4 (standard deviation (SD), 5.5) years from the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study (2002-2006). Cox proportional hazards models were used to estimate hazard ratios. After 8.8 years of follow-up, there were 1,942 deaths. For men, each SD-increment increase in muscle lean area, muscle quality, and strength was associated with lower mortality risk, with decreases ranging between 11% and 22%. Each SD-increment increase in intermuscular adipose tissue and intramuscular adipose tissue was associated with higher mortality risk (hazard ratio (HR) = 1.13 (95% confidence interval (CI): 1.06, 1.22) and HR = 1.23 (95% CI: 1.15, 1.30), respectively). For women, each SD-increment increase in muscle lean area, muscle quality, and strength was associated with lower mortality risk, with decreases ranging between 12% and 19%. Greater intramuscular adipose tissue was associated with an 8% higher mortality risk (HR = 1.08, 95% CI: 1.01, 1.16). This study shows that muscle composition is associated with mortality risk. These results also show the importance of improving muscle strength and area and lowering muscle adipose tissue infiltration.

  17. The California Hazards Institute

    NASA Astrophysics Data System (ADS)

    Rundle, J. B.; Kellogg, L. H.; Turcotte, D. L.

    2006-12-01

    California's abundant resources are linked with its natural hazards. Earthquakes, landslides, wildfires, floods, tsunamis, volcanic eruptions, severe storms, fires, and droughts afflict the state regularly. These events have the potential to become great disasters, like the San Francisco earthquake and fire of 1906, that overwhelm the capacity of society to respond. At such times, the fabric of civic life is frayed, political leadership is tested, economic losses can dwarf available resources, and full recovery can take decades. A patchwork of Federal, state and local programs are in place to address individual hazards, but California lacks effective coordination to forecast, prevent, prepare for, mitigate, respond to, and recover from, the harmful effects of natural disasters. Moreover, we do not know enough about the frequency, size, time, or locations where they may strike, nor about how the natural environment and man-made structures would respond. As California's population grows and becomes more interdependent, even moderate events have the potential to trigger catastrophes. Natural hazards need not become natural disasters if they are addressed proactively and effectively, rather than reactively. The University of California, with 10 campuses distributed across the state, has world-class faculty and students engaged in research and education in all fields of direct relevance to hazards. For that reason, the UC can become a world leader in anticipating and managing natural hazards in order to prevent loss of life and property and degradation of environmental quality. The University of California, Office of the President, has therefore established a new system-wide Multicampus Research Project, the California Hazards Institute (CHI), as a mechanism to research innovative, effective solutions for California. The CHI will build on the rich intellectual capital and expertise of the Golden State to provide the best available science, knowledge and tools for

  18. IDENTIFICATION OF AIRCRAFT HAZARDS

    SciTech Connect

    K.L. Ashley

    2005-03-23

    Aircraft hazards were determined to be potentially applicable to a repository at Yucca Mountain in the ''Monitored Geological Repository External Events Hazards Screening Analysis'' (BSC 2004, Section 6.4.1). That determination was conservatively based on limited knowledge of flight data in the area of concern and on crash data for aircraft of the type flying near Yucca Mountain. The purpose of this report is to identify specific aircraft hazards that may be applicable to a Monitored Geologic Repository (MGR) at Yucca Mountain using NUREG-0800, ''Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants'' (NRC 1987, Section 3.5.1.6), as guidance for the inclusion or exclusion of identified aircraft hazards. NUREG-0800 is being used here as a reference because some of the same considerations apply. The intended use of this report is to provide inputs for further screening and analysis of the identified aircraft hazards based on the criteria that apply to Category 1 and 2 event sequence analyses as defined in 10 CFR 63.2 (see Section 4). The scope of this technical report includes the evaluation of military, private, and commercial use of airspace in the 100-mile regional setting of the MGR at Yucca Mountain with the potential for reducing the regional setting to a more manageable size after consideration of applicable screening criteria (see Section 7).

  19. Identification of Aircraft Hazards

    SciTech Connect

    K. Ashley

    2006-12-08

    Aircraft hazards were determined to be potentially applicable to a repository at Yucca Mountain in ''Monitored Geological Repository External Events Hazards Screening Analysis'' (BSC 2005 [DIRS 174235], Section 6.4.1). That determination was conservatively based upon limited knowledge of flight data in the area of concern and upon crash data for aircraft of the type flying near Yucca Mountain. The purpose of this report is to identify specific aircraft hazards that may be applicable to a monitored geologic repository (MGR) at Yucca Mountain, using NUREG-0800, ''Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants'' (NRC 1987 [DIRS 103124], Section 3.5.1.6), as guidance for the inclusion or exclusion of identified aircraft hazards. The intended use of this report is to provide inputs for further screening and analysis of identified aircraft hazards based upon the criteria that apply to Category 1 and Category 2 event sequence analyses as defined in 10 CFR 63.2 [DIRS 176544] (Section 4). The scope of this report includes the evaluation of military, private, and commercial use of airspace in the 100-mile regional setting of the repository at Yucca Mountain with the potential for reducing the regional setting to a more manageable size after consideration of applicable screening criteria (Section 7).

  20. Seismic hazard in the eastern United States

    USGS Publications Warehouse

    Mueller, Charles; Boyd, Oliver; Petersen, Mark D.; Moschetti, Morgan P.; Rezaeian, Sanaz; Shumway, Allison

    2015-01-01

    The U.S. Geological Survey seismic hazard maps for the central and eastern United States were updated in 2014. We analyze results and changes for the eastern part of the region. Ratio maps are presented, along with tables of ground motions and deaggregations for selected cities. The Charleston fault model was revised, and a new fault source for Charlevoix was added. Background seismicity sources utilized an updated catalog, revised completeness and recurrence models, and a new adaptive smoothing procedure. Maximum-magnitude models and ground motion models were also updated. Broad, regional hazard reductions of 5%–20% are mostly attributed to new ground motion models with stronger near-source attenuation. The revised Charleston fault geometry redistributes local hazard, and the new Charlevoix source increases hazard in northern New England. Strong increases in mid- to high-frequency hazard at some locations—for example, southern New Hampshire, central Virginia, and eastern Tennessee—are attributed to updated catalogs and/or smoothing.

  1. Hazardous materials dictionary

    SciTech Connect

    Coleman, R.J.

    1987-01-01

    Parallel growth of the chemical industry of emergency response capabilities in the public and private sectors has created a new need for improved communications. A new vocabulary of important terms is emerging in each of the industries that transport, store and handle hazardous materials. This dictionary, representing a compilation of words and phrases from many relevant sources, will help document and standardize the nomenclature of hazardous materials. The authors have screened the technical discourse of the chemical, transportation, petroleum and medical fields, both governmental and private, to determine the most current expressions and their uses. The lexicographic goal has been to identify key terms, ambiguous and multiple meaning words, acronyms, symbols and even slang referring to hazardous materials reactions, storing and handling procedures.

  2. Moral Hazard in Pediatrics.

    PubMed

    Brunnquell, Donald; Michaelson, Christopher M

    2016-07-01

    "Moral hazard" is a term familiar in economics and business ethics that illuminates why rational parties sometimes choose decisions with bad moral outcomes without necessarily intending to behave selfishly or immorally. The term is not generally used in medical ethics. Decision makers such as parents and physicians generally do not use the concept or the word in evaluating ethical dilemmas. They may not even be aware of the precise nature of the moral hazard problem they are experiencing, beyond a general concern for the patient's seemingly excessive burden. This article brings the language and logic of moral hazard to pediatrics. The concept reminds us that decision makers in this context are often not the primary party affected by their decisions. It appraises the full scope of risk at issue when decision makers decide on behalf of others and leads us to separate, respect, and prioritize the interests of affected parties. PMID:27292845

  3. Cardiovascular effects of potential occupational hazards.

    PubMed

    Goldhaber, S Z

    1983-12-01

    Cardiovascular effects of potential occupational hazards have received relatively little attention. The major inhalant occupational exposures of concern are carbon disulfide, nitrates, halogenated hydrocarbons and carbon dioxide. Occupational exposure to certain trace metals may also be associated with adverse cardiovascular effects. Of concern is potential toxicity from cobalt, antimony, lead, cadmium and arsenic. Potential physical hazards exist in association with noise, heat and radiofrequency radiation. In most instances, the data are suggestive rather than conclusive. Further epidemiologic studies with careful control for potentially complicating factors, such as baseline differences in blood pressure, cigarette smoking habits and age, are needed. In some areas where epidemiologic studies have provided clues, the mechanisms of action of potential occupational hazards require further basic scientific investigation.

  4. Hazardous-Materials Robot

    NASA Technical Reports Server (NTRS)

    Stone, Henry W.; Edmonds, Gary O.

    1995-01-01

    Remotely controlled mobile robot used to locate, characterize, identify, and eventually mitigate incidents involving hazardous-materials spills/releases. Possesses number of innovative features, allowing it to perform mission-critical functions such as opening and unlocking doors and sensing for hazardous materials. Provides safe means for locating and identifying spills and eliminates risks of injury associated with use of manned entry teams. Current version of vehicle, called HAZBOT III, also features unique mechanical and electrical design enabling vehicle to operate safely within combustible atmosphere.

  5. Hazard Communication Standard

    SciTech Connect

    Sichak, S.

    1991-01-01

    The current rate of technological advances has brought with it an overwhelming increase in the usage of chemicals in the workplace and in the home. Coupled to this increase has been a heightened awareness in the potential for acute and chronic injuries attributable to chemical insults. The Hazard Communication Standard has been introduced with the desired goal of reducing workplace exposures to hazardous substances and thereby achieving a corresponding reduction in adverse health effects. It was created and proclaimed by the US Department of Labor and regulated by the Occupational Safety and Health Administration. 1 tab.

  6. Geothermal hazards - Mercury emission

    NASA Technical Reports Server (NTRS)

    Siegel, S. M.; Siegel, B. Z.

    1975-01-01

    Enthusiasm for intensified geothermal exploration may induce many participants to overlook a long-term potential toxicity hazard possibly associated with the tapping of magmatic steam. The association of high atmospheric Hg levels with geothermal activity has been established both in Hawaii and Iceland, and it has been shown that mercury can be introduced into the atmosphere from fumaroles, hot springs, and magmatic sources. These arguments, extended to thallium, selenium, and other hazardous elements, underscore the need for environmental monitoring in conjunction with the delivery of magmatic steam to the surface.

  7. Lightning hazards to aircraft

    NASA Technical Reports Server (NTRS)

    Corn, P. B.

    1978-01-01

    Lightning hazards and, more generally, aircraft static electricity are discussed by a representative for the Air Force Flight Dynamics Laboratory. An overview of these atmospheric electricity hazards to aircraft and their systems is presented with emphasis on electrical and electronic subsystems. The discussion includes reviewing some of the characteristics of lightning and static electrification, trends in weather and lightning-related mishaps, some specific threat mechanisms and susceptible aircraft subsystems and some of the present technology gaps. A roadmap (flow chart) is presented to show the direction needed to address these problems.

  8. Landslide hazard mitigation in North America

    USGS Publications Warehouse

    Wieczorek, G.F.; Leahy, P.P.

    2008-01-01

    Active landslides throughout the states and territories of the United States result in extensive property loss and 25-50 deaths per year. The U.S. Geological Survey (USGS) has a long history of detailed examination of landslides since the work of Howe (1909) in the San Juan Mountains of Colorado. In the last four decades, landslide inventory maps and landslide hazard maps have depicted landslides of different ages, identified fresh landslide scarps, and indicated the direction of landslide movement for different regions of the states of Colorado, California, and Pennsylvania. Probability-based methods improve landslide hazards assessments. Rainstorms, earthquakes, wildfires, and volcanic eruptions can trigger landslides. Improvements in remote sensing of rainfall make it possible to issue landslide advisories and warnings for vulnerable areas. From 1986 to 1995, the USGS issued hazard warnings based on rainfall in the San Francisco Bay area. USGS workers also identified rainfall thresholds triggering landslides in Puerto Rico, Hawaii, Washington, and the Blue Ridge Mountains of central Virginia. Detailed onsite monitoring of landslides near highways in California and Colorado aided transportation officials. The USGS developed a comprehensive, multi-sector, and multi-agency strategy to mitigate landslide hazards nationwide. This study formed the foundation of the National Landslide Hazards Mitigation Strategy. The USGS, in partnership with the U.S. National Weather Service and the State of California, began to develop a real-time warning system for landslides from wildfires in Southern California as a pilot study in 2005.

  9. Perceptions of hazard and risk on Santorini

    NASA Astrophysics Data System (ADS)

    Dominey-Howes, Dale; Minos-Minopoulos, Despina

    2004-10-01

    Santorini, Greece is a major explosive volcano. The Santorini volcanic complex is composed of two active volcanoes—Nea Kameni and Mt. Columbo. Holocene eruptions have generated a variety of processes and deposits and eruption mechanisms pose significant hazards of various types. It has been recognized that, for major European volcanoes, few studies have focused on the social aspects of volcanic activity and little work has been conducted on public perceptions of hazard, risk and vulnerability. Such assessments are an important element of establishing public education programmes and developing volcano disaster management plans. We investigate perceptions of volcanic hazards on Santorini. We find that most residents know that Nea Kameni is active, but only 60% know that Mt. Columbo is active. Forty percent of residents fear that negative impacts on tourism will have the greatest effect on their community. In the event of an eruption, 43% of residents would try to evacuate the island by plane/ferry. Residents aged >50 have retained a memory of the effects of the last eruption at the island, whereas younger residents have no such knowledge. We find that dignitaries and municipal officers (those responsible for planning and managing disaster response) are informed about the history, hazards and effects of the volcanoes. However, there is no "emergency plan" for the island and there is confusion between various departments (Civil Defense, Fire, Police, etc.) about the emergency decision-making process. The resident population of Santorini is at high risk from the hazards associated with a future eruption.

  10. Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians.

    PubMed

    Arai, Yasumichi; Martin-Ruiz, Carmen M; Takayama, Michiyo; Abe, Yukiko; Takebayashi, Toru; Koyasu, Shigeo; Suematsu, Makoto; Hirose, Nobuyoshi; von Zglinicki, Thomas

    2015-10-01

    To determine the most important drivers of successful ageing at extreme old age, we combined community-based prospective cohorts: Tokyo Oldest Old Survey on Total Health (TOOTH), Tokyo Centenarians Study (TCS) and Japanese Semi-Supercentenarians Study (JSS) comprising 1554 individuals including 684 centenarians and (semi-)supercentenarians, 167 pairs of centenarian offspring and spouses, and 536 community-living very old (85 to 99 years). We combined z scores from multiple biomarkers to describe haematopoiesis, inflammation, lipid and glucose metabolism, liver function, renal function, and cellular senescence domains. In Cox proportional hazard models, inflammation predicted all-cause mortality with hazard ratios (95% CI) 1.89 (1.21 to 2.95) and 1.36 (1.05 to 1.78) in the very old and (semi-)supercentenarians, respectively. In linear forward stepwise models, inflammation predicted capability (10.8% variance explained) and cognition (8(.)6% variance explained) in (semi-)supercentenarians better than chronologic age or gender. The inflammation score was also lower in centenarian offspring compared to age-matched controls with Δ (95% CI) = - 0.795 (- 1.436 to - 0.154). Centenarians and their offspring were able to maintain long telomeres, but telomere length was not a predictor of successful ageing in centenarians and semi-supercentenarians. We conclude that inflammation is an important malleable driver of ageing up to extreme old age in humans.

  11. Cables and fire hazards

    NASA Technical Reports Server (NTRS)

    Zanelli, C.; Philbrick, S.; Beretta, G.

    1986-01-01

    Besides describing the experiments conducted to develop a nonflammable cable, this article discusses several considerations regarding other hazards which might result from cable fires, particularly the toxicity and opacity of the fumes emitted by the burning cable. In addition, this article examines the effects of using the Oxygen Index as a gauge of quality control during manufacture.

  12. Earthquake hazard hunt

    USGS Publications Warehouse

    MacCabe, M. P.

    1980-01-01

    The Earthquake Hazard Hunt should begin at home, with all family members participating. Foresight, imagination, and commonsense are all that are needed as you go from room to room and imagine what would happen when the Earth and house started to shake. 

  13. Hazardous solvent substitution

    SciTech Connect

    Twitchell, K.E.

    1995-11-01

    Eliminating hazardous solvents is good for the environment, worker safety, and the bottom line. However, even though we are motivated to find replacements, the big question is `What can we use as replacements for hazardous solvents?`You, too, can find replacements for your hazardous solvents. All you have to do is search for them. Search through the vendor literature of hundreds of companies with thousands of products. Ponder the associated material safety data sheets, assuming of course that you can obtain them and, having obtained them, that you can read them. You will want to search the trade magazines and other sources for product reviews. You will want to talk to users about how well the product actually works. You may also want to check US Environmental Protection Agency (EPA) and other government reports for toxicity and other safety information. And, of course, you will want to compare the product`s constituent chemicals with the many hazardous constituency lists to ensure the safe and legal use of the product in your workplace.

  14. Hazardous Wastes from Homes.

    ERIC Educational Resources Information Center

    Lord, John

    The management of waste materials has become more complex with the increase in human population and the development of new substances. This illustrated booklet traces the history of waste management and provides guidelines for individuals and communities in disposing of certain hazardous wastes safely. It addresses such topics as: (1) how people…

  15. PERMITTING HAZARDOUS WASTE INCINERATORS

    EPA Science Inventory

    This publication is a compilation of information presented at a seminar series designed to address the issues that affect the issuance of hazardous waste incineration permits and to improve the overall understanding of trial burn testing. pecifically, the document provides guidan...

  16. Managing Academe's Hazardous Materials.

    ERIC Educational Resources Information Center

    Thompson, Fay

    1991-01-01

    Those responsible for planning and management of colleges and universities must plan comprehensively for hazardous waste disposal. Federal and state regulations are increasing, landfill area is becoming scarce, and incineration costs are rising fast. High-level institutional commitment to a sound campus environment policy is essential. (MSE)

  17. Hazards of Mercury.

    ERIC Educational Resources Information Center

    Environmental Research, 1971

    1971-01-01

    Common concern for the protection and improvement of the environment and the enhancement of human health and welfare underscore the purpose of this special report on the hazards of mercury directed to the Secretary's Pesticide Advisory Committee, Department of Health, Education, and Welfare. The report summarizes the findings of a ten-member study…

  18. The Impact Hazard

    NASA Technical Reports Server (NTRS)

    Morrison, David

    1994-01-01

    The Earth has been subject to hypervelocity impacts from comets and asteroids since its formation, and such impacts have played an important role in the evolution of life on our planet. We now recognize not only the historical role of impacts, but the contemporary hazard posed by such events. In the absence of a complete census of potentially threatening Earth-crossing asteroids or comets (called collectively Near Earth Objects, or NEOs), or even of a comprehensive cur-rent search program to identify NEOs, we can consider the hazard only from a probabilistic perspective. We know the steep power-law relationship between NEO numbers and size, with many more small bodies than large ones. We also know that few objects less than about 50 m in diameter (with kinetic energy near 10 megatons) penetrate the atmosphere and are capable of doing surface damage. But there is a spectrum of possible impact hazards associated with objects from this 10-megaton threshold all the way up to NEOs 5 km or larger in diameter, which are capable of inflicting severe damage on the environment, leading to mass extinction's of species. Detailed analysis has shown that, in general, the larger the object the greater the hazard, even when allowance is made for the infrequency of large impacts. Most of the danger to human life is associated with impacts by objects roughly 2 km or larger (energy greater than 1 million megatons), which can inject sufficient submicrometer dust into the atmosphere to produce a severe short-term global cooling with subsequent loss of crops, leading to starvation. Hazard estimates suggest that the chance of such an event occurring during a human lifetime is about 1:5000, and the global probability of death from such impacts is of the order of 1:20000, values that can be compared with risks associated with other natural hazards such as earthquakes, volcanic eruptions, and severe storms. However, the impact hazard differs from the others in that it can be largely

  19. Tank farms hazards assessment

    SciTech Connect

    Broz, R.E.

    1994-09-30

    Hanford contractors are writing new facility specific emergency procedures in response to new and revised US Department of Energy (DOE) Orders on emergency preparedness. Emergency procedures are required for each Hanford facility that has the potential to exceed the criteria for the lowest level emergency, an Alert. The set includes: (1) a facility specific procedure on Recognition and Classification of Emergencies, (2) area procedures on Initial Emergency Response and, (3) an area procedure on Protective Action Guidance. The first steps in developing these procedures are to identify the hazards at each facility, identify the conditions that could release the hazardous material, and calculate the consequences of the releases. These steps are called a Hazards Assessment. The final product is a document that is similar in some respects to a Safety Analysis Report (SAR). The document could br produced in a month for a simple facility but could take much longer for a complex facility. Hanford has both types of facilities. A strategy has been adopted to permit completion of the first version of the new emergency procedures before all the facility hazards Assessments are complete. The procedures will initially be based on input from a task group for each facility. This strategy will but improved emergency procedures in place sooner and therefore enhance Hanford emergency preparedness. The purpose of this document is to summarize the applicable information contained within the Waste Tank Facility ``Interim Safety Basis Document, WHC-SD-WM-ISB-001`` as a resource, since the SARs covering Waste Tank Operations are not current in all cases. This hazards assessment serves to collect, organize, document and present the information utilized during the determination process.

  20. The Golden Ratio

    ERIC Educational Resources Information Center

    Hyde, Hartley

    2004-01-01

    The Golden Ratio is sometimes called the "Golden Section" or the "Divine Proportion", in which three points: A, B, and C, divide a line in this proportion if AC/AB = AB/BC. "Donald in Mathmagicland" includes a section about the Golden Ratio and the ratios within a five-pointed star or pentagram. This article presents two computing exercises that…

  1. Counterfactual Volcano Hazard Analysis

    NASA Astrophysics Data System (ADS)

    Woo, Gordon

    2013-04-01

    The historical database of past disasters is a cornerstone of catastrophe risk assessment. Whereas disasters are fortunately comparatively rare, near-misses are quite common for both natural and man-made hazards. The word disaster originally means 'an unfavourable aspect of a star'. Except for astrologists, disasters are no longer perceived fatalistically as pre-determined. Nevertheless, to this day, historical disasters are treated statistically as fixed events, although in reality there is a large luck element involved in converting a near-miss crisis situation into a disaster statistic. It is possible to conceive a stochastic simulation of the past to explore the implications of this chance factor. Counterfactual history is the exercise of hypothesizing alternative paths of history from what actually happened. Exploring history from a counterfactual perspective is instructive for a variety of reasons. First, it is easy to be fooled by randomness and see regularity in event patterns which are illusory. The past is just one realization of a variety of possible evolutions of history, which may be analyzed through a stochastic simulation of an array of counterfactual scenarios. In any hazard context, there is a random component equivalent to dice being rolled to decide whether a near-miss becomes an actual disaster. The fact that there may be no observed disaster over a period of time may belie the occurrence of numerous near-misses. This may be illustrated using the simple dice paradigm. Suppose a dice is rolled every month for a year, and an event is recorded if a six is thrown. There is still an 11% chance of no events occurring during the year. A variety of perils may be used to illustrate the use of near-miss information within a counterfactual disaster analysis. In the domain of natural hazards, near-misses are a notable feature of the threat landscape. Storm surges are an obvious example. Sea defences may protect against most meteorological scenarios. However

  2. Autonomous Landing Hazard Avoidance Technology

    NASA Video Gallery

    Future NASA space crafts will be able to safely land on the Moon, Marsand even an asteroid, in potentially hazardous terrain areas, allautonomously. And NASA’s Autonomous Landing Hazard Avoidan...

  3. Seismic hazard maps for Haiti

    USGS Publications Warehouse

    Frankel, Arthur; Harmsen, Stephen; Mueller, Charles; Calais, Eric; Haase, Jennifer

    2011-01-01

    We have produced probabilistic seismic hazard maps of Haiti for peak ground acceleration and response spectral accelerations that include the hazard from the major crustal faults, subduction zones, and background earthquakes. The hazard from the Enriquillo-Plantain Garden, Septentrional, and Matheux-Neiba fault zones was estimated using fault slip rates determined from GPS measurements. The hazard from the subduction zones along the northern and southeastern coasts of Hispaniola was calculated from slip rates derived from GPS data and the overall plate motion. Hazard maps were made for a firm-rock site condition and for a grid of shallow shear-wave velocities estimated from topographic slope. The maps show substantial hazard throughout Haiti, with the highest hazard in Haiti along the Enriquillo-Plantain Garden and Septentrional fault zones. The Matheux-Neiba Fault exhibits high hazard in the maps for 2% probability of exceedance in 50 years, although its slip rate is poorly constrained.

  4. Hazardous waste management

    SciTech Connect

    Miller, S.

    1981-12-01

    An international meeting held at the State Department in Washington, DC on hazardous waste management is discussed. The conference was held by the Committee on the Challenges to Modern Society of the North Atlantic Treaty Organization. Among the wastes considered at the meeting were chromium wastes, lead wastes, pesticides, mercury wastes, nickel wastes, oil refinery wastes, PCBs, cadmium wastes, and others. Radioactive wastes were not considered. Legislation, landfill use, recycling, and the Common Market's approach to these wastes were also discussed. (JMT)

  5. Publication: Evansville hazard maps

    USGS Publications Warehouse

    ,

    2012-01-01

    The Evansville (Indiana) Area Earthquake Hazards Mapping Project was completed in February 2012. It was a collaborative effort among the U.S. Geological Survey and regional partners Purdue University; the Center for Earthquake Research and Information at the University of Memphis; the state geologic surveys of Kentucky, Illinois, and Indiana; the Southwest Indiana Disaster Resistant Community Corporation; and the Central U.S. Earthquake Consortium state geologists.

  6. California's potential volcanic hazards

    USGS Publications Warehouse

    Jorgenson, P.

    1989-01-01

    This is a summary of "Potential Hazards from Future Volcanic Eruptions in California' (USGS Bulletin No. 1847: price $4.75). The chief areas of danger are Lassen Peak, Mount Shasta and Medicine Lake Highland in the north; Clear Lake, Mono Lake and Long Valley in the centre; and Owen's River-Death Valley, Amboy Crater and the Saltan Butter in the south of the State. -A.Scarth

  7. Hazardous factories: Nigerian evidence.

    PubMed

    Oloyede, Olajide

    2005-06-01

    The past 15 years have seen an increasing governmental and corporate concern for the environment worldwide. For governments, information about the environmental performance of the industrial sector is required to inform macro-level decisions about environmental targets such as those required to meet UN directives. However, in many African, Asian, and Latin American countries, researching and reporting company environmental performance is limited. This article serves as a contribution to filling the gap by presenting evidence of physical and chemical risk in Nigerian factories. One hundred and three factories with a total of 5,021 workers were studied. One hundred and twenty physical and chemical hazards were identified and the result shows a high number of workers exposed to such hazards. The study also reveals that workers' awareness level of chemical hazards was high. Yet the danger was perceived in behavioral terms, especially by manufacturing firms, which tend to see environmental investment in an increasingly global economy as detrimental to profitability. PMID:16022703

  8. PUREX facility hazards assessment

    SciTech Connect

    Sutton, L.N.

    1994-09-23

    This report documents the hazards assessment for the Plutonium Uranium Extraction Plant (PUREX) located on the US Department of Energy (DOE) Hanford Site. Operation of PUREX is the responsibility of Westinghouse Hanford Company (WHC). This hazards assessment was conducted to provide the emergency planning technical basis for PUREX. DOE Order 5500.3A requires an emergency planning hazards assessment for each facility that has the potential to reach or exceed the lowest level emergency classification. In October of 1990, WHC was directed to place PUREX in standby. In December of 1992 the DOE Assistant Secretary for Environmental Restoration and Waste Management authorized the termination of PUREX and directed DOE-RL to proceed with shutdown planning and terminal clean out activities. Prior to this action, its mission was to reprocess irradiated fuels for the recovery of uranium and plutonium. The present mission is to establish a passively safe and environmentally secure configuration at the PUREX facility and to preserve that condition for 10 years. The ten year time frame represents the typical duration expended to define, authorize and initiate follow-on decommissioning and decontamination activities.

  9. Identifying and modeling safety hazards

    SciTech Connect

    DANIELS,JESSE; BAHILL,TERRY; WERNER,PAUL W.

    2000-03-29

    The hazard model described in this paper is designed to accept data over the Internet from distributed databases. A hazard object template is used to ensure that all necessary descriptors are collected for each object. Three methods for combining the data are compared and contrasted. Three methods are used for handling the three types of interactions between the hazard objects.

  10. Hazard Maps in the Classroom.

    ERIC Educational Resources Information Center

    Cross, John A.

    1988-01-01

    Emphasizes the use of geophysical hazard maps and illustrates how they can be used in the classroom from kindergarten to college level. Depicts ways that hazard maps of floods, landslides, earthquakes, volcanoes, and multi-hazards can be integrated into classroom instruction. Tells how maps may be obtained. (SLM)

  11. Volcanic hazards to airports

    USGS Publications Warehouse

    Guffanti, M.; Mayberry, G.C.; Casadevall, T.J.; Wunderman, R.

    2009-01-01

    Volcanic activity has caused significant hazards to numerous airports worldwide, with local to far-ranging effects on travelers and commerce. Analysis of a new compilation of incidents of airports impacted by volcanic activity from 1944 through 2006 reveals that, at a minimum, 101 airports in 28 countries were affected on 171 occasions by eruptions at 46 volcanoes. Since 1980, five airports per year on average have been affected by volcanic activity, which indicates that volcanic hazards to airports are not rare on a worldwide basis. The main hazard to airports is ashfall, with accumulations of only a few millimeters sufficient to force temporary closures of some airports. A substantial portion of incidents has been caused by ash in airspace in the vicinity of airports, without accumulation of ash on the ground. On a few occasions, airports have been impacted by hazards other than ash (pyroclastic flow, lava flow, gas emission, and phreatic explosion). Several airports have been affected repeatedly by volcanic hazards. Four airports have been affected the most often and likely will continue to be among the most vulnerable owing to continued nearby volcanic activity: Fontanarossa International Airport in Catania, Italy; Ted Stevens Anchorage International Airport in Alaska, USA; Mariscal Sucre International Airport in Quito, Ecuador; and Tokua Airport in Kokopo, Papua New Guinea. The USA has the most airports affected by volcanic activity (17) on the most occasions (33) and hosts the second highest number of volcanoes that have caused the disruptions (5, after Indonesia with 7). One-fifth of the affected airports are within 30 km of the source volcanoes, approximately half are located within 150 km of the source volcanoes, and about three-quarters are within 300 km; nearly one-fifth are located more than 500 km away from the source volcanoes. The volcanoes that have caused the most impacts are Soufriere Hills on the island of Montserrat in the British West Indies

  12. Permafrost Hazards and Linear Infrastructure

    NASA Astrophysics Data System (ADS)

    Stanilovskaya, Julia; Sergeev, Dmitry

    2014-05-01

    The international experience of linear infrastructure planning, construction and exploitation in permafrost zone is being directly tied to the permafrost hazard assessment. That procedure should also consider the factors of climate impact and infrastructure protection. The current global climate change hotspots are currently polar and mountain areas. Temperature rise, precipitation and land ice conditions change, early springs occur more often. The big linear infrastructure objects cross the territories with different permafrost conditions which are sensitive to the changes in air temperature, hydrology, and snow accumulation which are connected to climatic dynamics. One of the most extensive linear structures built on permafrost worldwide are Trans Alaskan Pipeline (USA), Alaska Highway (Canada), Qinghai-Xizang Railway (China) and Eastern Siberia - Pacific Ocean Oil Pipeline (Russia). Those are currently being influenced by the regional climate change and permafrost impact which may act differently from place to place. Thermokarst is deemed to be the most dangerous process for linear engineering structures. Its formation and development depend on the linear structure type: road or pipeline, elevated or buried one. Zonal climate and geocryological conditions are also of the determining importance here. All the projects are of the different age and some of them were implemented under different climatic conditions. The effects of permafrost thawing have been recorded every year since then. The exploration and transportation companies from different countries maintain the linear infrastructure from permafrost degradation in different ways. The highways in Alaska are in a good condition due to governmental expenses on annual reconstructions. The Chara-China Railroad in Russia is under non-standard condition due to intensive permafrost response. Standards for engineering and construction should be reviewed and updated to account for permafrost hazards caused by the

  13. [Relations of landslide and debris flow hazards to environmental factors].

    PubMed

    Zhang, Guo-ping; Xu, Jing; Bi, Bao-gui

    2009-03-01

    To clarify the relations of landslide and debris flow hazards to environmental factors is of significance to the prediction and evaluation of landslide and debris flow hazards. Base on the latitudinal and longitudinal information of 18431 landslide and debris flow hazards in China, and the 1 km x 1 km grid data of elevation, elevation difference, slope, slope aspect, vegetation type, and vegetation coverage, this paper analyzed the relations of landslide and debris flow hazards in this country to above-mentioned environmental factors by the analysis method of frequency ratio. The results showed that the landslide and debris flow hazards in China more occurred in lower elevation areas of the first and second transitional zones. When the elevation difference within a 1 km x 1 km grid cell was about 300 m and the slope was around 30 degree, there was the greatest possibility of the occurrence of landslide and debris hazards. Mountain forest land and slope cropland were the two land types the hazards most easily occurred. The occurrence frequency of the hazards was the highest when the vegetation coverage was about 80%-90%.

  14. Impact of Increasing Age on Outcomes of Spinal Fusion in Adult Idiopathic Scoliosis

    PubMed Central

    Verla, Terence; Adogwa, Owoicho; Toche, Ulysses; Farber, S. Harrison; Petraglia, Frank; Murphy, Kelly R.; Thomas, Steven; Fatemi, Parastou; Gottfried, Oren; Bagley, Carlos A.; Lad, Shivanand P.

    2016-01-01

    Objective To investigate the role of advancing age on postoperative complications and revision surgery after fusion for scoliosis. Methods A retrospective, cohort study was performed using the Thomson Reuters MarketScan database, examining patients with adult scoliosis who underwent spinal fusion from 2000 to 2009. Primary outcomes included infection, hemorrhage and pulmonary embolism (PE) within 90 days of surgery, and refusion. The effect of increasing age was estimated using the odds ratio (OR) of complications in a multivariate logistic regression analysis, and a Cox proportional hazard model estimated the hazard ratio of refusion. Results A total of 8432 patients were included in this study. Overall, the average age was 53.3 years, with 26.90% males and 39% with a Charlson Comorbidity Score of ≥1. Most patients had commercial insurance (66.81%), with 26.03% and 7.16% covered by Medicare and Medicaid, respectively. Increasing age (per 5-year increment) was a significant predictor of hemorrhagic complication (OR, 1.06; confidence interval [CI], 1.01–1.11; P = 0.0196), PE (OR, 1.09; CI, 1.03–1.16; P = 0.0031), infection (OR, 1.04; CI, 1.01–1.07; P = 0.0053), and refusion (hazard ratio, 1.07; CI, 1.02–1.13; P = 0.0103). Conclusions In this study, age was associated with increased risk of hemorrhage, PE, infection, and refusion. With the aging population, the role of patient age on postoperative healing and outcomes deserves deeper investigation after repair of adult idiopathic scoliosis. PMID:26546999

  15. Radiation Hazard Detector

    NASA Technical Reports Server (NTRS)

    1978-01-01

    NASA technology has made commercially available a new, inexpensive, conveniently-carried device for protection, of people exposed to potentially dangerous levels of microwave radiation. Microwaves are radio emissions of extremely high frequency. They can be hazardous but the degree of hazard is not yet well understood. Generally, it is believed that low intensity radiation of short duration is not harmful but that exposure to high levels can induce deep internal burns, affecting the circulatory and nervous systems, and particularly the eyes. The Department of Labor's Occupational Safety and Health Administration (OSHA) has established an allowable safe threshold of exposure. However, people working near high intensity sources of microwave energy-for example, radar antennas and television transmitters-may be unknowingly exposed to radiation levels beyond the safe limit. This poses not only a personal safety problem but also a problem for employers in terms of productivity loss, workman's compensation claims and possible liability litigation. Earlier-developed monitoring devices which warn personnel of dangerous radiation levels have their shortcomings. They can be cumbersome and awkward to use while working. They also require continual visual monitoring to determine if a person is in a dangerous area of radiation, and they are relatively expensive, another deterrent to their widespread adoption. In response to the need for a cheaper and more effective warning system, Jet Propulsion Laboratory developed, under NASA auspices, a new, battery-powered Microwave Radiation Hazard Detector. To bring the product to the commercial market, California Institute Research Foundation, the patent holder, granted an exclusive license to Cicoil Corporation, Chatsworth, California, an electronic components manufacturer.

  16. Compression Ratio Adjuster

    NASA Technical Reports Server (NTRS)

    Akkerman, J. W.

    1982-01-01

    New mechanism alters compression ratio of internal-combustion engine according to load so that engine operates at top fuel efficiency. Ordinary gasoline, diesel and gas engines with their fixed compression ratios are inefficient at partial load and at low-speed full load. Mechanism ensures engines operate as efficiently under these conditions as they do at highload and high speed.

  17. Offer/Acceptance Ratio.

    ERIC Educational Resources Information Center

    Collins, Mimi

    1997-01-01

    Explores how human resource professionals, with above average offer/acceptance ratios, streamline their recruitment efforts. Profiles company strategies with internships, internal promotion, cooperative education programs, and how to get candidates to accept offers. Also discusses how to use the offer/acceptance ratio as a measure of program…

  18. Detecting isotopic ratio outliers

    SciTech Connect

    Bayne, C.K.; Smith, D.H.

    1985-01-01

    An alternative method is proposed for improving isotopic ratio estimates. This method mathematically models pulse-count data and uses iterative reweighted Poisson regression to estimate model parameters to calculate the isotopic ratios. This computer-oriented approach provides theoretically better methods than conventional techniques to establish error limits and to identify outliers. 6 refs., 3 figs., 3 tabs.

  19. Rocket plume burn hazard.

    PubMed

    Stoll, A M; Piergallini, J R; Chianta, M A

    1980-05-01

    By use of miniature rocket engines, the burn hazard posed by exposure to ejection seat rocket plume flames was determined in the anaesthetized rat. A reference chart is provided for predicting equivalent effects in human skin based on extrapolation of earlier direct measurements of heat input for rat and human burns. The chart is intended to be used in conjunction with thermocouple temperature measurements of the plume environment for design and modification of escape seat system to avoid thermal injury on ejection from multiplace aircraft. PMID:7387571

  20. Landing Hazard Avoidance Display

    NASA Technical Reports Server (NTRS)

    Abernathy, Michael Franklin (Inventor); Hirsh, Robert L. (Inventor)

    2016-01-01

    Landing hazard avoidance displays can provide rapidly understood visual indications of where it is safe to land a vehicle and where it is unsafe to land a vehicle. Color coded maps can indicate zones in two dimensions relative to the vehicles position where it is safe to land. The map can be simply green (safe) and red (unsafe) areas with an indication of scale or can be a color coding of another map such as a surface map. The color coding can be determined in real time based on topological measurements and safety criteria to thereby adapt to dynamic, unknown, or partially known environments.

  1. Toxic Hazards Research Unit

    NASA Technical Reports Server (NTRS)

    Macewen, J. D.; Vernot, E. H.

    1971-01-01

    The activities of the Toxic Hazards Research Unit (THRU) for the period of June 1970 through May 1971 reviewed. Modification of the animal exposure facilities primarily for improved human safety but also for experimental integrity and continuity are discussed. Acute toxicity experiments were conducted on hydrogen fluoride (HF), hydrogen chloride (HCl), nitrogen dioxide (NO2), and hydrogen cyanide (HCN) both singly and in combination with carbon dioxide (CO). Additional acute toxicity experiments were conducted on oxygen difluoride (OF2) and chlorine pentafluoride (ClF5). Subacute toxicity studies were conducted on methylisobutylketone and dichloromethane (methylene dichloride). The interim results of further chronic toxicity experiments on monomethylhydrazine (MMH) are also described.

  2. Hazards of geomagnetic storms

    USGS Publications Warehouse

    Herzog, D.C.

    1992-01-01

    Geomagnetic storms are large and sometimes rapid fluctuations in the Earth's magnetic field that are related to disturbances on the Sun's surface. Although it is not widely recognized, these transient magnetic disturbances can be a significant hazard to people and property. Many of us know that the intensity of the auroral lights increases during magnetic storms, but few people realize that these storms can also cause massive power outages, interrupt radio communications and satellite operations, increase corrosion in oil and gas pipelines, and lead to spuriously high rejection rates in the manufacture of sensitive electronic equipment. 

  3. Specialized ratio analysis.

    PubMed

    Wyer, J C; Salzinger, F H

    1983-01-01

    Many common management techniques have little use in managing a medical group practice. Ratio analysis, however, can easily be adapted to the group practice setting. Acting as broad-gauge indicators, financial ratios provide an early warning of potential problems and can be very useful in planning for future operations. The author has gathered a collection of financial ratios which were developed by participants at an education seminar presented for the Virginia Medical Group Management Association. Classified according to the human element, system component, and financial factor, the ratios provide a good sampling of measurements relevant to medical group practices and can serve as an example for custom-tailoring a ratio analysis system for your medical group.

  4. Hazard proximities of childhood cancers in Great Britain from 1953-80.

    PubMed Central

    Knox, E G; Gilman, E A

    1997-01-01

    STUDY OBJECTIVES: Firstly, to examine relationships between the birth and death addresses of children dying from leukaemia and cancer in Great Britain, and the sites of potential environmental hazards; and secondly to measure relative case densities close to, and at increasing distances from, different hazard types. DESIGN: Home address postcodes (PCs) and their map coordinates were identified at birth and at death in children who died from leukaemia or cancer. Potentially hazardous industrial addresses and PCs were listed from business and other directories, and map coordinates obtained from the Central Postcode Directory or else located directly on Ordnance Survey (OS) maps. Railway lines and motorways were digitised from OS maps. Numbers of deaths (and births) at successive radial distances from these hazards were counted and compared with expected numbers. The latter were based on a count of all PCs at similar distances. Relative case density ratios at successive distances from the hazards were obtained from observed and expected numbers, aggregated over similar sites. This was repeated for different hazard types and results were tested for evidence of systematic centrifugal case density gradients. PARTICIPANTS AND SETTING: All 22,458 children dying from leukaemia or cancer aged 0-15 years, in England, Wales, and Scotland, between 1953 and 1980. MAIN RESULTS: Relative excesses of leukaemias and of solid cancers were found near the following: (1) oil refineries, major oil storage installations, railside oil distribution terminals and factories making bitumen products; (2) motor car factories, coach builders, and car body repairers; (3) major users of petroleum products including manufacturers of solvents, paint sprayers, fibreglass fabricators, paint and varnish makers, plastics and detergent manufacturers, and galvanisers; (4) users of kilns and furnaces including steelworks, power stations, galvanisers, cement makers, brickworks, crematoria and aluminium, zinc

  5. Prenatal famine exposure and adult mortality from cancer, cardiovascular disease, and other causes through age 63 years.

    PubMed

    Ekamper, Peter; van Poppel, Frans; Stein, Aryeh D; Bijwaard, Govert E; Lumey, L H

    2015-02-15

    Nutritional conditions in early life may affect adult health, but prior studies of mortality have been limited to small samples. We evaluated the relationship between pre-/perinatal famine exposure during the Dutch Hunger Winter of 1944-1945 and mortality through age 63 years among 41,096 men born in 1944-1947 and examined at age 18 years for universal military service in the Netherlands. Of these men, 22,952 had been born around the time of the Dutch famine in 6 affected cities; the remainder served as unexposed controls. Cox proportional hazards models were used to estimate hazard ratios for death from cancer, heart disease, other natural causes, and external causes. After 1,853,023 person-years of follow-up, we recorded 1,938 deaths from cancer, 1,040 from heart disease, 1,418 from other natural causes, and 523 from external causes. We found no increase in mortality from cancer or cardiovascular disease after prenatal famine exposure. However, there were increases in mortality from other natural causes (hazard ratio = 1.24, 95% confidence interval: 1.03, 1.49) and external causes (hazard ratio = 1.46, 95% confidence interval: 1.09, 1.97) after famine exposure in the first trimester of gestation. Further follow-up of the cohort is needed to provide more accurate risk estimates of mortality from specific causes of death after nutritional disturbances during gestation and very early life.

  6. Sex-ratio patterns of AIDS patients in Thailand.

    PubMed

    Rerks-Ngarm, S

    1997-01-01

    The summary report of AIDS cases in Thailand, as of 31 July 1996, was reviewed for the information on male-to female sex-ratio. The ratios were recalculated for different risk-factors and for different age-groups annually and cumulatively. The male-to-female ratios calculated for annual case reports are lower than the cumulative number. This finding demonstrates the earlier detection of change in risk behaviour among the general population by the sex-ratio from annual case reports, compared to the ratio from the cumulative number of cases. Among different age-groups, the older age shows the highest male-to-female ratio. The ratio among sexually active age-group (15-49 years of age) is declining during the most recent year. These changes confirm the present pattern of AIDS epidemic in Thailand, the fourth wave among females, followed by the last wave-pediatric AIDS.

  7. Communication in hazardous environments

    SciTech Connect

    Rankin, W N; Herold, T R

    1986-01-01

    Radios were investigated for use in hazardous environments where protective breathing equipment such as plastic suits and respirators interfere with communication. A radio system, manufactured by Communications-Applied technology (C-AT), was identified that was designed specifically for hazardous environment communications. This equipment had been used successfully by the US Army and NASA for several years. C-AT equipment was evaluated in plantwide applications at the Savannah River Plant (SRP) using temporary frequencies obtained by the Department of Energy-Savannah River (DOE-SR). Radios performed well in all applications, which included a tritium facility, high-level caves, a nuclear reactor building, tank farm, and a canyon building interior. Permanent frequencies were obtained by DOE-SR for two complete six-man C-AT systems at SRP. Because of the relatively short range of these systems, replicates will cover all applications of this type of equipment plantwide. Twelve radio systems are currently being used successfully in plantwide applications.

  8. Hazards assessment for the Hazardous Waste Storage Facility

    SciTech Connect

    Knudsen, J.K.; Calley, M.B.

    1994-04-01

    This report documents the hazards assessment for the Hazardous Waste Storage Facility (HWSF) located at the Idaho National Engineering Laboratory. The hazards assessment was performed to ensure that this facility complies with DOE and company requirements pertaining to emergency planning and preparedness for operational emergencies. The hazards assessment identifies and analyzes hazards that are significant enough to warrant consideration in a facility`s operational emergency management program. The area surrounding HWSF, the buildings and structures at HWSF, and the processes used at HWSF are described in this report. All nonradiological hazardous materials at the HWSF were identified (radiological hazardous materials are not stored at HWSF) and screened against threshold quantities according to DOE Order 5500.3A guidance. Two of the identified hazardous materials exceeded their specified threshold quantity. This report discusses the potential release scenarios and consequences associated with an accidental release for each of the two identified hazardous materials, lead and mercury. Emergency considerations, such as emergency planning zones, emergency classes, protective actions, and emergency action levels, are also discussed based on the analysis of potential consequences. Evaluation of the potential consequences indicated that the highest emergency class for operational emergencies at the HWSF would be a Site Area Emergency.

  9. Birthweight ratio revisited.

    PubMed Central

    Brownlee, K G; Ng, P C; Roussounis, S H; Dear, P R

    1991-01-01

    In order to test the hypothesis suggested in a recent report that the birthweight ratio might be a useful predictor of several important clinical outcome measures in babies of less than 31 weeks' gestation, we examined the association between the birthweight ratio and aspects of both short and long term outcome in 436 Leeds babies of less than 31 weeks' gestation. Unlike the report, and contrary to what we had expected, we were unable to find any significant association between birthweight ratio and length of time on the ventilator, mortality, neurological outcome, or intellectual outcome. PMID:2025035

  10. Older drivers' insight into their hazard perception ability.

    PubMed

    Horswill, Mark S; Anstey, Kaarin J; Hatherly, Christopher; Wood, Joanne M; Pachana, Nancy A

    2011-11-01

    Even though the driving ability of older adults may decline with age, there is evidence that some individuals attempt to compensate for these declines using strategies such as restricting their driving exposure. Such compensatory mechanisms rely on drivers' ability to evaluate their own driving performance. This paper focuses on one key aspect of driver ability that is associated with crash risk and has been found to decline with age: hazard perception. Three hundred and seven drivers, aged 65-96, completed a validated video-based hazard perception test. There was no significant relationship between hazard perception test response latencies and drivers' ratings of their hazard perception test performance, suggesting that their ability to assess their own test performance was poor. Also, age-related declines in hazard perception latency were not reflected in drivers' self-ratings. Nonetheless, ratings of test performance were associated with self-reported regulation of driving, as was self-rated driving ability. These findings are consistent with the proposal that, while self-assessments of driving ability may be used by drivers to determine the degree to which they restrict their driving, the problem is that drivershave little insight into their own driving ability. This may impact on the potential road safety benefits of self-restriction of driving because drivers may not have the information needed to optimally self-restrict. Strategies for addressing this problem are discussed.

  11. Blood Cell Palmitoleate-Palmitate Ratio Is an Independent Prognostic Factor for Amyotrophic Lateral Sclerosis

    PubMed Central

    Henriques, Alexandre; Blasco, Hélène; Fleury, Marie-Céline; Corcia, Philippe; Echaniz-Laguna, Andoni; Robelin, Laura; Rudolf, Gabrielle; Lequeu, Thiebault; Bergaentzle, Martine; Gachet, Christian; Pradat, Pierre-François; Marchioni, Eric; Andres, Christian R.; Tranchant, Christine; Gonzalez De Aguilar, Jose-Luis; Loeffler, Jean-Philippe

    2015-01-01

    Growing evidence supports a link between fatty acid metabolism and amyotrophic lateral sclerosis (ALS). Here we determined the fatty acid composition of blood lipids to identify markers of disease progression and survival. We enrolled 117 patients from two clinical centers and 48 of these were age and gender matched with healthy volunteers. We extracted total lipids from serum and blood cells, and separated fatty acid methyl esters by gas chromatography. We measured circulating biochemical parameters indicative of the metabolic status. Association between fatty acid composition and clinical readouts was studied, including ALS functional rating scale-revised (ALSFRS-R), survival, disease duration, site of onset and body mass index. Palmitoleate (16:1) and oleate (18:1) levels, and stearoyl-CoA desaturase indices (16:1/16:0 and 18:1/18:0) significantly increased in blood cells from ALS patients compared to healthy controls. Palmitoleate levels and 16:1/16:0 ratio in blood cells, but not body mass index or leptin concentrations, negatively correlated with ALSFRS-R decline over a six-month period (p<0.05). Multivariate Cox analysis, with age, body mass index, site of onset and ALSFRS-R as covariables, showed that blood cell 16:1/16:0 ratio was an independent prognostic factor for survival (hazard ratio=0.1 per unit of ratio, 95% confidence interval=0.01-0.57, p=0.009). In patients with high 16:1/16:0 ratio, survival at blood collection was extended by 10 months, as compared to patients with low ratio. The 16:1/16:0 index is an easy-to-handle parameter that predicts survival of ALS patients independently of body mass index. It therefore deserves further validation in larger cohorts for being used to assess disease outcome and effects of disease-modifying drugs. PMID:26147510

  12. Hazard assessment of selenium to endangered razorback suckers (Xyrauchen texanus)

    USGS Publications Warehouse

    Hamilton, S.J.; Holley, K.M.; Buhl, K.J.

    2002-01-01

    A hazard assessment was conducted based on information derived from two reproduction studies conducted with endangered razorback suckers (Xyrauchen texanus) at three sites near Grand Junction, CO, USA. Selenium contamination of the upper and lower Colorado River basin has been documented in water, sediment, and biota in studies by US Department of the Interior agencies and academia. Concern has been raised that this selenium contamination may be adversely affecting endangered fish in the upper Colorado River basin. The reproduction studies with razorback suckers revealed that adults readily accumulated selenium in various tissues including eggs, and that 4.6 ??g/g of selenium in food organisms caused increased mortality of larvae. The selenium hazard assessment protocol resulted in a moderate hazard at the Horsethief site and high hazards at the Adobe Creek and North Pond sites. The selenium hazard assessment was considered conservative because an on-site toxicity test with razorback sucker larvae using 4.6 ??g/g selenium in zooplankton caused nearly complete mortality, in spite of the moderate hazard at Horsethief. Using the margin of uncertainty ratio also suggested a high hazard for effects on razorback suckers from selenium exposure. Both assessment approaches suggested that selenium in the upper Colorado River basin adversely affects the reproductive success of razorback suckers. ?? 2002 Elsevier Science B.V. All rights reserved.

  13. Hazard assessment of selenium to endangered razorback suckers (Xyrauchen texanus).

    PubMed

    Hamilton, Steven J; Holley, Kathleen M; Buhl, Kevin J

    2002-05-27

    A hazard assessment was conducted based on information derived from two reproduction studies conducted with endangered razorback suckers (Xyrauchen texanus) at three sites near Grand Junction, CO, USA. Selenium contamination of the upper and lower Colorado River basin has been documented in water, sediment, and biota in studies by US Department of the Interior agencies and academia. Concern has been raised that this selenium contamination may be adversely affecting endangered fish in the upper Colorado River basin. The reproduction studies with razorback suckers revealed that adults readily accumulated selenium in various tissues including eggs, and that 4.6 microg/g of selenium in food organisms caused increased mortality of larvae. The selenium hazard assessment protocol resulted in a moderate hazard at the Horsethief site and high hazards at the Adobe Creek and North Pond sites. The selenium hazard assessment was considered conservative because an on-site toxicity test with razorback sucker larvae using 4.6 microg/g selenium in zooplankton caused nearly complete mortality, in spite of the moderate hazard at Horsethief. Using the margin of uncertainty ratio also suggested a high hazard for effects on razorback suckers from selenium exposure. Both assessment approaches suggested that selenium in the upper Colorado River basin adversely affects the reproductive success of razorback suckers. PMID:12150431

  14. Hazardous solvent source reduction

    SciTech Connect

    Callahan, M.S.; Green, B.

    1995-09-01

    This book is written for the managers, production leaders, and operations staff tasked with the job of eliminating hazardous cleaning solvents from their workplace. Information regarding the location, evaluation, and implementation of environmentally preferred cleaning technologies is offered for a broad range of applications. These include: removal of grease and grime from a piece of equipment during maintenance, cleaning small parts before assembly, defluxing printed circuit boards and assemblies, and stripping paint from field vehicles and aircraft. Moving beyond the limits of source reduction alone, this book provides complete information on the planning, staffing, and execution of a pollution prevention program, alternative and in-use cleaner testing, waste recycling and treatment, air emission control, replacement system design, and system economics. For the environmental specialist, this book helps to bridge the gap between regulatory requirements and shop-floor constraints.

  15. New hazardous waste solutions

    SciTech Connect

    Krukowski, J.

    1993-05-15

    From data supplied by industrial laboratories, from academia, and from the EPA's Superfund Innovative Site Evaluation (SITE) program, this paper presents an informal look at some new and innovative hazardous waste treatment processes. These processes show promise for sparing users off-site disposal costs as well as for remediation of contamination at Superfund or RCRA sites. Included are the following: equipment that will biodegrade water-based paint wastes and pesticide wastes; recycling of potliner and furnace dusts for metal recovery; a process that reduces PCBs and PAHs to lighter hydrocarbons such as methane. Finally, two radiofrequency (RF) processes are described that can be used to remove soil contaminants such as pentachlorophenols, Aroclor 1242, solvents, oils, jet fuel, and pesticides.

  16. Sports: The Infectious Hazards.

    PubMed

    Minooee, Arezou; Wang, Jeff; Gupta, Geeta K

    2015-10-01

    Although the medical complications of sports are usually traumatic in nature, infectious hazards also arise. While blood-borne pathogens such as HIV, hepatitis B, and hepatitis C, cause significant illness, the risk of acquiring these agents during sporting activities is minimal. Skin infections are more commonplace, arising from a variety of microbial agents including bacterial, fungal, and viral pathogens. Sports involving water contact can lead to enteric infections, eye infections, or disseminated infections such as leptospirosis. Mumps, measles, and influenza are vaccine-preventable diseases that have been transmitted during sporting events, both in players and in spectators. Prevention is the key to many of these infections. Players should be vaccinated and should not participate in sports if their infection can be spread by contact, airborne, or droplet transmission.

  17. Secondary impact hazard assessment

    NASA Technical Reports Server (NTRS)

    1986-01-01

    A series of light gas gun shots (4 to 7 km/sec) were performed with 5 mg nylon and aluminum projectiles to determine the size, mass, velocity, and spatial distribution of spall and ejecta from a number of graphite/epoxy targets. Similar determinations were also performed on a few aluminum targets. Target thickness and material were chosen to be representative of proposed Space Station structure. The data from these shots and other information were used to predict the hazard to Space Station elements from secondary particles resulting from impacts of micrometeoroids and orbital debris on the Space Station. This hazard was quantified as an additional flux over and above the primary micrometeoroid and orbital debris flux that must be considered in the design process. In order to simplify the calculations, eject and spall mass were assumed to scale directly with the energy of the projectile. Other scaling systems may be closer to reality. The secondary particles considered are only those particles that may impact other structure immediately after the primary impact. The addition to the orbital debris problem from these primary impacts was not addressed. Data from this study should be fed into the orbital debris model to see if Space Station secondaries make a significant contribution to orbital debris. The hazard to a Space Station element from secondary particles above and beyond the micrometeoroid and orbital debris hazard is categorized in terms of two factors: (1) the 'view factor' of the element to other Space Station structure or the geometry of placement of the element, and (2) the sensitivity to damage, stated in terms of energy. Several example cases were chosen, the Space Station module windows, windows of a Shuttle docked to the Space Station, the habitat module walls, and the photovoltaic solar cell arrays. For the examples chosen the secondary flux contributed no more than 10 percent to the total flux (primary and secondary) above a given calculated

  18. Runoff inundation hazard cartography

    NASA Astrophysics Data System (ADS)

    Pineux, N.; Degré, A.

    2012-04-01

    Between 1998 and 2004, Europe suffered from more than hundred major inundations, responsible for some 700 deaths, for the moving of about half a million of people and the economic losses of at least 25 billions Euros covered by the insurance policies. Within this context, EU launched the 2007/60/CE directive. The inundations are natural phenomenon. They cannot be avoided. Nevertheless this directive permits to better evaluate the risks and to coordinate the management measures taken at member states level. In most countries, inundation maps only include rivers' overflowing. In Wallonia, overland flows and mudflows also cause huge damages, and must be included in the flood hazard map. Indeed, the cleaning operations for a village can lead to an estimated cost of 11 000 €. Average construction cost of retention dams to control off-site damage caused by floods and muddy flows was valued at 380 000€, and yearly dredging costs associated with these retention ponds at 15 000€. For a small city for which a study was done in a more specific way (Gembloux), the mean annual cost for the damages that can generate the runoff is about 20 000€. This cost consists of the physical damages caused to the real estate and movable properties of the residents as well as the emergency operations of the firemen and the city. On top of damages to public infrastructure (clogging of trenches, silting up of retention ponds) and to private property by muddy flows, runoff generates a significant loss of arable land. Yet, the soil resource is not an unlimited commodity. Moreover, sediments' transfer to watercourses alters their physical and chemical quality. And that is not to mention the increased psychological stress for people. But to map overland flood and mud flow hazard is a real challenge. This poster will present the methodology used to in Wallonia. The methodology is based on 3 project rainfalls: 25, 50 and 100 years return period (consistency with the cartography of the

  19. Landslide Hazard in Georgia

    NASA Astrophysics Data System (ADS)

    Gaprindashvili, G.; Tsereteli, E.; Gaprindashvili, M.

    2013-12-01

    In the last decades of the XX century, protect the population from geological hazards, to maintain land and safe operation of the engineering facilities has become the most important social - economic, demographic, political and environmental problems for the whole world. Georgia, with its scales of origination of the natural-catastrophic processes (landslide, mudflow, rockfall, erosion and etc.), their re-occurrence and with the negative results inflicted by these processes to the population, agricultural lands and engineering objects, is one of the most complex mountainous region. The extremely sensitive conditions were conditioned by: 1. Activation of highly intense earthquakes; 2. Activation of the negative meteorological events provoking the disaster processes on the background of global climatic changes and their abnormally frequent occurrence (mostly increased atmospheric precipitations, temperature and humidity); 3. Large-scale Human impact on the environment. Following the problem urgency, a number of departmental and research institutions have made their operations more intense in the given direction within the limits of their competence. First of all, the activity of the Department of Geology of Georgia (which is at present included in the National Environmental Agency of the Ministry of Environment and Natural Resources Protection), which mapped, identified and cataloged the hazardous processes on the territory of the country and identified the spatial limits and developmental regularities of these processes for tens of years. The increased risk of Geological catastrophes in Georgia first of all is caused by insufficient information between society and responsible persons toward this event. The existed situation needs the base assessment of natural disasters level, the identification of events, to determine their caused reasons, to develop special maps in GIS system, and continuous functioning of geo monitoring researches for develop safety early

  20. Landslide Hazard in Georgia

    NASA Astrophysics Data System (ADS)

    Gaprindashvili, George; Tsereteli, Emil; Gaprindashvili, Merab

    2014-05-01

    In the last decades of the XX century, protect the population from geological hazards, to maintain land and safe operation of the engineering facilities has become the most important social - economic, demographic, political and environmental problems for the whole world. Georgia, with its scales of origination of the natural-catastrophic processes (landslide, mudflow, rockfall, erosion and etc.), their re-occurrence and with the negative results inflicted by these processes to the population, agricultural lands and engineering objects, is one of the most complex mountainous region. The extremely sensitive conditions were conditioned by: 1. Activation of highly intense earthquakes; 2. Activation of the negative meteorological events provoking the disaster processes on the background of global climatic changes and their abnormally frequent occurrence (mostly increased atmospheric precipitations, temperature and humidity); 3. Large-scale Human impact on the environment. Following the problem urgency, a number of departmental and research institutions have made their operations more intense in the given direction within the limits of their competence. First of all, the activity of the Department of Geology of Georgia (which is at present included in the National Environmental Agency of the Ministry of Environment and Natural Resources Protection), which mapped, identified and cataloged the hazardous processes on the territory of the country and identified the spatial limits and developmental regularities of these processes for tens of years. The increased risk of Geological catastrophes in Georgia first of all is caused by insufficient information between society and responsible persons toward this event. The existed situation needs the base assessment of natural disasters level, the identification of events, to determine their caused reasons, to develop special maps in GIS system, and continuous functioning of geo monitoring researches for develop safety early

  1. The longer-term effects of a brief hazard perception training intervention in older drivers.

    PubMed

    Horswill, Mark S; Falconer, Emmaline K; Pachana, Nancy A; Wetton, Mark; Hill, Andrew

    2015-03-01

    Previous research has shown that drivers aged over 65 years can improve their scores in video-based hazard perception tests following training interventions. In order to examine the longer-term effects of hazard perception training, we recruited 75 drivers aged 65 and over. They either received a 35-min hazard perception training intervention or a placebo intervention. Significant decreases in hazard perception response time as a result of the training were found immediately after the intervention, and approximately 1 month and 3 months later. There was no significant decay in the training effect over this time period.

  2. Informing Workers of Chemical Hazards: The OSHA Hazard Communication Standard.

    ERIC Educational Resources Information Center

    American Chemical Society, Washington, DC.

    Practical information on how to implement a chemical-related safety program is outlined in this publication. Highlights of the federal Occupational Safety and Health Administrations (OSHA) Hazard Communication Standard are presented and explained. These include: (1) hazard communication requirements (consisting of warning labels, material safety…

  3. Earthquake Hazard and Risk Assessment for Turkey

    NASA Astrophysics Data System (ADS)

    Betul Demircioglu, Mine; Sesetyan, Karin; Erdik, Mustafa

    2010-05-01

    Using a GIS-environment to present the results, seismic risk analysis is considered as a helpful tool to support the decision making for planning and prioritizing seismic retrofit intervention programs at large scale. The main ingredients of seismic risk analysis consist of seismic hazard, regional inventory of buildings and vulnerability analysis. In this study, the assessment of the national earthquake hazard based on the NGA ground motion prediction models and the comparisons of the results with the previous models have been considered, respectively. An evaluation of seismic risk based on the probabilistic intensity ground motion prediction for Turkey has been investigated. According to the Macroseismic approach of Giovinazzi and Lagomarsino (2005), two alternative vulnerability models have been used to estimate building damage. The vulnerability and ductility indices for Turkey have been taken from the study of Giovinazzi (2005). These two vulnerability models have been compared with the observed earthquake damage database. A good agreement between curves has been clearly observed. In additional to the building damage, casualty estimations based on three different methods for each return period and for each vulnerability model have been presented to evaluate the earthquake loss. Using three different models of building replacement costs, the average annual loss (AAL) and probable maximum loss ratio (PMLR) due to regional earthquake hazard have been provided to form a basis for the improvement of the parametric insurance model and the determination of premium rates for the compulsory earthquake insurance in Turkey.

  4. Motorcycling experience and hazard perception.

    PubMed

    Crundall, David; van Loon, Editha; Stedmon, Alex W; Crundall, Elizabeth

    2013-01-01

    Studies of hazard perception skills in car drivers suggest that the ability to spot hazards improves with driving experience. Is this the case with motorcyclists? Sixty-one motorcyclists, split across three groups (novice, experienced and advanced riders) were tested on a hazard perception test containing video clips filmed from the perspective of a motorcyclist. Response times to hazards revealed that the advanced riders (who had completed an advanced riding course) were the fastest, and the experienced riders were the slowest to respond to hazards, with novice riders falling in-between. Advanced riders were also found to make more internal attributions regarding the causes of the hazards than novice riders (though on a general measure of Locus of Control there was no difference between groups). The results demonstrate a link between advanced training and motorcycling hazard perception skill, but raise important concerns about the effects of mere experience on rider safety. This challenges previous conceptions that simply extrapolated from our understanding of the hazard perception skills of car drivers to this particularly vulnerable group of road users.

  5. Michigan Household Hazardous Substance Handbook.

    ERIC Educational Resources Information Center

    Senior, Janet; Stone Nancy

    Common household hazardous substances include cleansers, drain cleaners, automotive products, paints, solvents, and pesticides. This handbook was designed to serve as a resource for people frequently contacted by the public for information on household hazardous substances and wastes. Included in the handbook are: (1) an introduction to Michigan's…

  6. Hazard Tree Management for Camps.

    ERIC Educational Resources Information Center

    Kong, Earl

    2002-01-01

    The principles behind a camp's hazard tree program are, first, identifying and removing those hazards that offer a clear, immediate threat, and then creating a management plan for the other trees. The plan should be written and contain goals and objectives, field evaluations, and treatments. Follow-up evaluations should be done annually and after…

  7. Hazardous waste: cleanup and prevention

    USGS Publications Warehouse

    Vandas, Stephen; Cronin, Nancy L.; Farrar, Frank; Serrano, Guillermo Eliezer Ávila; Yajimovich, Oscar Efraín González; Muñoz, Aurora R.; Rivera, María del C.

    1996-01-01

    Our lifestyles are supported by complex Industrial activities that produce many different chemicals and chemical wastes. The Industries that produce our clothing, cars, medicines, paper, food, fuels, steel, plastics, and electric components use and discard thousands of chemicals every year. At home we may use lawn chemicals, solvents, disinfectants, cleaners, and auto products to Improve our quality of life. A chemical that presents a threat or unreasonable risk to people or the environment Is a hazardous material. When a hazardous material can no longer be used, It becomes a hazardous waste. Hazardous wastes come from a variety of sources, from both present and past activities. Impacts to human health and the environment can result from Improper handling and disposal of hazardous waste.

  8. Age at Graft Loss after Pediatric Kidney Transplantation: Exploring the High-Risk Age Window

    PubMed Central

    Van Arendonk, Kyle J.; James, Nathan T.; Boyarsky, Brian J.; Garonzik-Wang, Jacqueline M.; Orandi, Babak J.; Magee, John C.; Smith, Jodi M.; Colombani, Paul M.

    2013-01-01

    Summary Background and objective The risk of graft loss after pediatric kidney transplantation increases during late adolescence and early adulthood, but the extent to which this phenomenon affects all recipients is unknown. This study explored interactions between recipient factors and this high-risk age window, searching for a recipient phenotype that may be less susceptible during this detrimental age interval. Design, setting, participants, & measurements With use of Scientific Registry of Transplant Recipients data from 1987 to 2010, risk of graft loss across recipient age was quantified using a multivariable piecewise-constant hazard rate model with time-varying coefficients for recipient risk factors. Results Among 16,266 recipients, graft loss during ages ≥17 and <24 years was greater than that for both 3–17 years (adjusted hazard ratio [aHR], 1.61; P<0.001) and ≥24 years (aHR, 1.28; P<0.001). This finding was consistent across age at transplantation, sex, race, cause of renal disease, insurance type, pretransplant dialysis history, previous transplant, peak panel-reactive antibody (PRA), and type of induction immunosuppression. The high-risk window was seen in both living-donor and deceased-donor transplant recipients, at all levels of HLA mismatch, regardless of centers’ pediatric transplant volume, and consistently over time. The relationship between graft loss risk and donor type, PRA, transplant history, insurance type, and cause of renal disease was diminished upon entry into the high-risk window. Conclusions No recipient subgroups are exempt from the dramatic increase in graft loss during late adolescence and early adulthood, a high-risk window that modifies the relationship between typical recipient risk factors and graft loss. PMID:23430210

  9. A Recipe for Ratio

    ERIC Educational Resources Information Center

    Moffett, Pamela

    2012-01-01

    Many learners still struggled to appreciate, and understand the difference between, the concepts of fractions and ratio. This is not just a UK phenomenon, which is demonstrated here by the use of a resource developed by the Wisconsin Centre for Education, in association with the Freudenthal Institute of the University of Utrecht, with a group of…

  10. Area Ratios of Quadrilaterals.

    ERIC Educational Resources Information Center

    Anderson, David R.; Arcidiacono, Michael J.

    1989-01-01

    Shows that the ratio of the area of the quadrilateral formed by joining the kth points to the area of the original quadrilateral is constant whether it is convex or concave quadrilateral. Presents many geoboard or dot paper diagrams and geometrical expresssions. (YP)

  11. Seismic hazard assessments at Islamic Cairo, Egypt

    NASA Astrophysics Data System (ADS)

    Khalil, A. E.; Deif, A.; Abdel Hafiez, H. E.

    2015-12-01

    Islamic Cairo is one of the important Islamic monumental complexes in Egypt, near the center of present-day metropolitan Cairo. The age of these buildings is up to one thousand years. Unfortunately, many of the buildings are suffering from huge mishandling that may lead to mass damage. Many buildings and masjids were partially and totally collapsed because of 12th October 1992 Cairo earthquake that took place at some 25 km from the study area with a magnitude Mw = 5.8. Henceforth, potential damage assessments there are compulsory. The deterministic and probabilistic techniques were used to predict the expected future large earthquakes' strong-motion characteristics in the study area. The current study started with compiling the available studies concerned with the distribution of the seismogenic sources and earthquake catalogs. The deterministic method is used to provide a description of the largest earthquake effect on the area of interest, while the probabilistic method, on the other hand, is used to define the uniform hazard curves at three time periods 475, 950, 2475 years. Both deterministic and probabilistic results were obtained for bedrock conditions and the resulted hazard levels were deaggregated to identify the contribution of each seismic source to the total hazard. Moreover, the results obtained show that the expected seismic activities combined with the present situation of the buildings pose high alert to rescue both the cultural heritage and expected human losses.

  12. Hamburger hazards and emotions.

    PubMed

    Olsen, Nina Veflen; Røssvoll, Elin; Langsrud, Solveig; Scholderer, Joachim

    2014-07-01

    Previous studies indicate that many consumers eat rare hamburgers and that information about microbiological hazards related to undercooked meat not necessarily leads to more responsible behavior. With this study we aim to investigate whether consumers' willingness to eat hamburgers depends on the emotions they experience when confronted with the food. A representative sample of 1046 Norwegian consumers participated in an online experiment. In the first part, participants were randomly divided into two groups. One group was confronted with a picture of a rare hamburger, whereas the other group was confronted with a picture of a well-done hamburger. The respondents were instructed to imagine that they were served the hamburger on the picture and then to indicate which emotions they experienced: fear, disgust, surprise, interest, pleasure, or none of these. In part two, all respondents were confronted with four pictures of hamburgers cooked to different degrees of doneness (rare, medium rare, medium well-done, well-done), and were asked to state their likelihood of eating. We analyzed the data by means of a multivariate probit model and two linear fixed-effect models. The results show that confrontation with rare hamburgers evokes more fear and disgust than confrontation with well-done hamburgers, that all hamburgers trigger pleasure and interest, and that a consumer's willingness to eat rare hamburgers depends on the particular type of emotion evoked. These findings indicate that emotions play an important role in a consumer's likelihood of eating risky food, and should be considered when developing food safety strategies.

  13. Phytoremediation of hazardous wastes

    SciTech Connect

    McCutcheon, S.C.; Wolfe, N.L.; Carreria, L.H.; Ou, T.Y.

    1995-11-01

    A new and innovative approach to phytoremediation (the use of plants to degrade hazardous contaminants) was developed. The new approach to phytoremediation involves rigorous pathway analyses, mass balance determinations, and identification of specific enzymes that break down trinitrotoluene (TNT), other explosives (RDX and HMX), nitrobenzene, and chlorinated solvents (e.g., TCE and PCE) (EPA 1994). As a good example, TNT is completely and rapidly degraded by nitroreductase and laccase enzymes. The aromatic ring is broken and the carbon in the ring fragments is incorporated into new plant fiber, as part of the natural lignification process. Half lives for TNT degradation approach 1 hr or less under ideal laboratory conditions. Continuous-flow pilot studies indicate that scale up residence times in created wetlands may be two to three times longer than in laboratory batch studies. The use of created wetlands and land farming techniques guided by rigorous field biochemistry and ecology promises to be a vital part of a newly evolving field, ecological engineering.

  14. Contaminant Hazard Reviews (compilation)

    USGS Publications Warehouse

    Eisler, R.; Munro, R.E.; Loges, L.M.; Boone, K.; Paul, M.M.; Garrett, L.J.

    2000-01-01

    This compact disc (CD) contains the 35 reports in the Contaminant Hazard Reviews (CHR) that were published originally between 1985 and 1999 in the U.S. Department of the Interior Biological Report series. The CD was produced because printed supplies of these reviews--a total of 105,000--became exhausted and demand remained high. Each review was prepared at the request of environmental specialists of the U.S. Fish and Wildlife Service and each contained specific information on the following: mirex, cadmium, carbofuran, toxaphene, selenium, chromium, polychlorinated biphenyls, dioxins, diazinon, mercury, polycyclic aromatic hydrocarbons, arsenic, chlorpyrifos, lead, tin, index issue, pentachlorophenol, atrazine, molybdenum, boron, chlordane, paraquat, cyanide, fenvalerate, diflubenzuron, zinc, famphur, acrolein, radiation, sodium monofluoroacetate, planar PCBs, silver, copper, nickel, and a cumulative index to chemicals and species. Each report reviewed and synthesized the technical literature on a single contaminant and its effects on terrestrial plants and invertebrates, aquatic plants and animals, avian and mammalian wildlife, and other natural resources. The subtopics include contaminant sources and uses; physical, chemical, and metabolic properties; concentrations in field collections of abiotic materials and living organisms; deficiency effects, where appropriate; lethal and sublethal effects, including effects on survival, growth, reproduction, metabolism, mutagenicity, teratogenicity, and carcinogenicity; proposed criteria for the protection of human health and sensitive natural resources; and recommendations for additional research.

  15. Handbook of hazard communication and OSHA requirements

    SciTech Connect

    Lowry, G.G.

    1985-01-01

    This guide gives an understanding of the OSHA Hazard Communication Standard which regulates hazardous materials in the workplace. Contents include: how to identify hazards in the workplace; characterization of hazards; label design and content; written hazard communication program; employee training; legal responsibilities including penalties and consequences; and a MSDS form.

  16. 49 CFR 386.72 - Imminent hazard.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Imminent hazard. 386.72 Section 386.72... Injunctions and Imminent Hazards § 386.72 Imminent hazard. (a) Whenever it is determined that an imminent hazard exists as a result of the transportation by motor vehicle of a particular hazardous material,...

  17. A low aspect ratio tokamak transmutation system

    NASA Astrophysics Data System (ADS)

    Qiu, L. J.; Wu, Y. C.; Xiao, B. J.; Xu, Q.; Huang, Q. Y.; Wu, B.; Chen, Y. X.; Xu, W. N.; Chen, Y. P.; Liu, X. P.

    2000-03-01

    A low aspect ratio tokamak transmutation system is proposed as an alternative application of fusion energy on the basis of a review of previous studies. This system includes: (1) a low aspect ratio tokamak as fusion neutron driver, (2) a radioactivity-clean nuclear power system as blanket, and (3) a novel concept of liquid metal centre conductor post as part of the toroidal field coils. In the conceptual design, a driver of 100 MW fusion power under 1 MW/m2 neutron wall loading can transmute the amount of high level waste (including minor actinides and fission products) produced by ten standard pressurized water reactors of 1 GW electrical power output. Meanwhile, the system can produce tritium on a self-sustaining basis and an output of about 2 GW of electrical energy. After 30 years of operation, the biological hazard potential level of the whole system will decrease by two orders of magnitude.

  18. 78 FR 42998 - Hazardous Materials: Improving the Safety of Railroad Transportation of Hazardous Materials

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-18

    ... TRANSPORTATION Federal Railroad Administration Hazardous Materials: Improving the Safety of Railroad Transportation of Hazardous Materials AGENCY: Pipeline and Hazardous Materials, Safety Administration (PHMSA... participate in a public meeting addressing the transportation of hazardous materials by rail. FRA and......

  19. Development of evaluation method for software hazard identification techniques

    SciTech Connect

    Huang, H. W.; Chen, M. H.; Shih, C.; Yih, S.; Kuo, C. T.; Wang, L. H.; Yu, Y. C.; Chen, C. W.

    2006-07-01

    This research evaluated the applicable software hazard identification techniques nowadays, such as, Preliminary Hazard Analysis (PHA), Failure Modes and Effects Analysis (FMEA), Fault Tree Analysis (FTA), Markov chain modeling, Dynamic Flow-graph Methodology (DFM), and simulation-based model analysis; and then determined indexes in view of their characteristics, which include dynamic capability, completeness, achievability, detail, signal/noise ratio, complexity, and implementation cost. By this proposed method, the analysts can evaluate various software hazard identification combinations for specific purpose. According to the case study results, the traditional PHA + FMEA + FTA (with failure rate) + Markov chain modeling (with transfer rate) combination is not competitive due to the dilemma for obtaining acceptable software failure rates. However, the systematic architecture of FTA and Markov chain modeling is still valuable for realizing the software fault structure. The system centric techniques, such as DFM and simulation-based model-analysis, show the advantage on dynamic capability, achievability, detail, signal/noise ratio. However, their disadvantages are the completeness complexity and implementation cost. This evaluation method can be a platform to reach common consensus for the stakeholders. Following the evolution of software hazard identification techniques, the evaluation results could be changed. However, the insight of software hazard identification techniques is much more important than the numbers obtained by the evaluation. (authors)

  20. 40 CFR 63.5330 - How do I determine the compliance ratio?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... National Emission Standards for Hazardous Air Pollutants for Leather Finishing Operations Compliance Requirements § 63.5330 How do I determine the compliance ratio? (a) When your source has processed leather...

  1. Landslide hazards and systems analysis: A Central European perspective

    NASA Astrophysics Data System (ADS)

    Klose, Martin; Damm, Bodo; Kreuzer, Thomas

    2016-04-01

    Part of the problem with assessing landslide hazards is to understand the variable settings in which they occur. There is growing consensus that hazard assessments require integrated approaches that take account of the coupled human-environment system. Here we provide a synthesis of societal exposure and vulnerability to landslide hazards, review innovative approaches to hazard identification, and lay a focus on hazard assessment, while presenting the results of historical case studies and a landslide time series for Germany. The findings add to a growing body of literature that recognizes societal exposure and vulnerability as a complex system of hazard interactions that evolves over time as a function of social change and development. We therefore propose to expand hazard assessments by the framework and concepts of systems analysis (e.g., Liu et al., 2007) Results so far have been promising in ways that illustrate the importance of feedbacks, thresholds, surprises, and time lags in the evolution of landslide hazard and risk. In densely populated areas of Central Europe, landslides often occur in urbanized landscapes or on engineered slopes that had been transformed or created intentionally by human activity, sometimes even centuries ago. The example of Germany enables to correlate the causes and effects of recent landslides with the historical transition of urbanization to urban sprawl, ongoing demographic change, and some chronic problems of industrialized countries today, including ageing infrastructures or rising government debts. In large parts of rural Germany, the combination of ageing infrastructures, population loss, and increasing budget deficits starts to erode historical resilience gains, which brings especially small communities to a tipping point in their efforts to risk reduction. While struggling with budget deficits and demographic change, these communities are required to maintain ageing infrastructures that are particularly vulnerable to

  2. [Vibration hazards in quarry workers].

    PubMed

    Sakakibara, H; Miyao, M; Nakagawa, T; Yamada, S; Kobayashi, F; Ono, Y; Iwata, M; Hisanaga, N; Momoi, N

    1984-03-01

    Vibration hazards were surveyed in a population of quarry workers using chipping hammers and to a lesser extent, rock drills. Sixty-nine male quarry workers, aged 49.1 +/- 8.7 and exposed to vibration for 16.4 +/- 5.1 years, were surveyed in 1981-82. They were exposed to vibration for about 2-4 hours per days, mainly under a piece-work pay system. They had a high prevalence of Raynaud's phenomenon (36.2%) and numbness in upper extremities (53.6%). It is considered that the high prevalence was mainly due to large vibration levels in chipping hammers and rock drills and long daily exposure time. The attacks of Raynaud's phenomenon were found predominantly in the left hand, which held chisels, whereas the restriction of motion in the elbow was predominantly in the right arm which pushed chipping hammers. The same 49 male quarry workers in this population were also surveyed in 1976-77 and the prevalence of their complaints between 1976-77 and 1981-82 was compared. The prevalence of Raynaud's phenomenon was the same, but the frequency of the attacks increased between the two periods. The prevalence of other complaints such as numbness, pain and chills in the upper extremities also increased. Between 1976-77 and 1981-82, the prevalence of Raynaud's phenomenon, numbness, and pain in the upper extremities increased in the population of quarriers exposed to vibration for above 2.6 hours per day and 200 days per year, or 600 hours per year. On the other hand, the prevalence of these complaints mostly decreased in the population of quarriers with less exposure.

  3. Age-Dependent Metastatic Spread and Survival: Cancer of Unknown Primary as a Model

    PubMed Central

    Hemminki, Kari; Pavlidis, Nicholas; Tsilidis, Konstantinos K.; Sundquist, Kristina; Ji, Jianguang

    2016-01-01

    In order to describe a novel approach for the clinical study of metastases, we provide here age-specific incidence and survival data for cancer of unknown primary (CUP). Metastases in various organs are found at CUP diagnosis, which have implications for prognosis, and we hypothesize similar prognostic implications for metastases found at diagnosis of primary cancers. We identified 33,224 CUP patients from the Swedish Cancer Registry and calculated incidence rates (IRs) for CUP development. Cox proportional hazards regression models were performed to estimate hazard ratios (HRs) for relative survival in CUP patients compared to the general population. In age-group specific analyses, a maximal IR was reached at age 85–89 years, followed by a marked decline to age 90+ (7-fold in men and 3-fold in women). The overall HR for relative survival declined systematically by age. CUP may be applied as an epidemiological age-incidence model for cancer metastases providing evidence in line with autopsy data that the metastatic potential, as shown by the incidence of CUP, appears to weaken markedly at age 85 years, depending on metastatic locations. The relative death rates were highest among young patients, which was probably entirely due to the low death rates in young background population. PMID:27009354

  4. Hazard interaction analysis for multi-hazard risk assessment: a systematic classification based on hazard-forming environment

    NASA Astrophysics Data System (ADS)

    Liu, B.; Siu, Y. L.; Mitchell, G.

    2015-12-01

    This paper develops a systematic hazard interaction classification based on the geophysical environment that natural hazards arise from - the hazard-forming environment. According to their contribution to natural hazards, geophysical environmental factors in the hazard-forming environment were categorized into two types. The first are relatively stable factors which construct the precondition for the occurrence of natural hazards, whilst the second are trigger factors, which determine the frequency and magnitude of hazards. Different combinations of geophysical environmental factors induce different hazards. Based on these geophysical environmental factors for some major hazards, the stable factors are used to identify which kinds of natural hazards influence a given area, and trigger factors are used to classify the relationships between these hazards into four types: independent, mutex, parallel and series relationships. This classification helps to ensure all possible hazard interactions among different hazards are considered in multi-hazard risk assessment. This can effectively fill the gap in current multi-hazard risk assessment methods which to date only consider domino effects. In addition, based on this classification, the probability and magnitude of multiple interacting natural hazards occurring together can be calculated. Hence, the developed hazard interaction classification provides a useful tool to facilitate improved multi-hazard risk assessment.

  5. Hazard interaction analysis for multi-hazard risk assessment: a systematic classification based on hazard-forming environment

    NASA Astrophysics Data System (ADS)

    Liu, Baoyin; Siu, Yim Ling; Mitchell, Gordon

    2016-03-01

    This paper develops a systematic hazard interaction classification based on the geophysical environment that natural hazards arise from - the hazard-forming environment. According to their contribution to natural hazards, geophysical environmental factors in the hazard-forming environment were categorized into two types. The first are relatively stable factors which construct the precondition for the occurrence of natural hazards, whilst the second are trigger factors, which determine the frequency and magnitude of hazards. Different combinations of geophysical environmental factors induce different hazards. Based on these geophysical environmental factors for some major hazards, the stable factors are used to identify which kinds of natural hazards influence a given area, and trigger factors are used to classify the relationships between these hazards into four types: independent, mutex, parallel and series relationships. This classification helps to ensure all possible hazard interactions among different hazards are considered in multi-hazard risk assessment. This can effectively fill the gap in current multi-hazard risk assessment methods which to date only consider domino effects. In addition, based on this classification, the probability and magnitude of multiple interacting natural hazards occurring together can be calculated. Hence, the developed hazard interaction classification provides a useful tool to facilitate improved multi-hazard risk assessment.

  6. Infrasound Monitoring of Natural Hazards

    NASA Astrophysics Data System (ADS)

    Arrowsmith, S.

    2015-12-01

    Infrasound is generated by a wide variety of energetic natural and anthropogenic phenomena that originate in the solid earth, ocean, and atmosphere. Because the absorption of infrasound is low, it can propagate long distances through atmospheric waveguides, making it a valuable tool for remote monitoring of hazards. Advances in using infrasound for monitoring energetic events in the solid earth, oceans, and atmosphere are being driven by the wealth of new datasets in addition to advances in modeling source and propagation physics. This presentation provides an overview of recent advances in infrasound monitoring of natural hazards, focusing on selected hazards in the earth (earthquakes and volcanoes), ocean (tsunamis), and atmosphere (meteoroids).

  7. 78 FR 52954 - Final Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-27

    ... SECURITY Federal Emergency Management Agency Final Flood Hazard Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Final notice. SUMMARY: Flood hazard determinations, which may include additions or modifications of Base Flood Elevations (BFEs), base flood depths, Special Flood Hazard...

  8. 78 FR 52953 - Final Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-27

    ... SECURITY Federal Emergency Management Agency Final Flood Hazard Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Final Notice. SUMMARY: Flood hazard determinations, which may include additions or modifications of Base Flood Elevations (BFEs), base flood depths, Special Flood Hazard...

  9. 78 FR 5820 - Final Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-28

    ... SECURITY Federal Emergency Management Agency Final Flood Hazard Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Final Notice. SUMMARY: Flood hazard determinations, which may include additions or modifications of Base Flood Elevations (BFEs), base flood depths, Special Flood Hazard...

  10. 78 FR 5821 - Final Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-28

    ... SECURITY Federal Emergency Management Agency Final Flood Hazard Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Final Notice. SUMMARY: Flood hazard determinations, which may include additions or modifications of Base Flood Elevations (BFEs), base flood depths, Special Flood Hazard...

  11. 78 FR 21143 - Final Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-09

    ... SECURITY Federal Emergency Management Agency Final Flood Hazard Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Final notice. SUMMARY: Flood hazard determinations, which may include additions or modifications of Base Flood Elevations (BFEs), base flood depths, Special Flood Hazard...

  12. An Introduction to Hazardous Material Management.

    ERIC Educational Resources Information Center

    Reinhardt, Peter A.; And Others

    1987-01-01

    Colleges must have a system to safely control the ordering, delivery, transport, storage, and use of hazardous material. Information on hazardous material management is excerpted from "Managing Hazardous Waste at Educational Institutions. (MLW)

  13. Estimating differences and ratios in median times to event

    PubMed Central

    Rogawski, Elizabeth T.; Westreich, Daniel J.; Kang, Gagandeep; Ward, Honorine D.; Cole, Stephen R.

    2016-01-01

    Time differences and time ratios are often more interpretable estimates of effect than hazard ratios for time-to-event data, especially for common outcomes. We developed a SAS macro for estimating time differences and time ratios between baseline-fixed binary exposure groups based on inverse probability weighted Kaplan-Meier curves. The macro uses pooled logistic regression to calculate inverse probability of censoring and exposure weights, draws Kaplan-Meier curves based on the weighted data, and estimates the time difference and time ratio at a user-defined survival proportion. The macro also calculates the risk difference and risk ratio at a user-specified time. Confidence intervals are constructed by bootstrap. We provide an example assessing the effect of exclusive breastfeeding during diarrhea on the incidence of subsequent diarrhea in children followed from birth to 3 years in Vellore, India. The SAS macro provided here should facilitate the wider reporting of time differences and time ratios. PMID:27465526

  14. Gestational age

    MedlinePlus

    Fetal age - gestational age; Gestation; Neonatal gestational age; Newborn gestational age ... Gestational age can be determined before or after birth. Before birth, your health care provider will use ultrasound to ...

  15. RCRA hazardous waste contingency plans

    SciTech Connect

    Wagner, T.P. )

    1991-10-01

    This paper reports that the Resource Conservation and Recovery Act (RCRA) requires hazardous waste treatment, storage and disposal facilities (TSDFs) to prepare a contingency plan. The plan is a blueprint for emergency response, and must be designed to minimize health and environmental hazards resulting from fires, explosions or other unplanned hazardous releases. Hazardous waste contingency plans often are neglected and considered an unnecessary regulatory exercise by facility operators. However, an effective contingency plan is a valuable tool for reducing liability, protecting workers and the community, and avoiding costly shutdowns. The requirement under Title III of the Superfund Amendments and Reauthorization Act (SARA) that regulated facilities report to EPA annually on releases to the environment has caused regulators to renew emphasis on the importance of RCRA contingency plans. However, regulatory agencies historically have provided insufficient information on the elements of an adequate contingency plan. Nevertheless, facility operators seriously should consider going beyond minimum regulatory requirements and create a comprehensive contingency plan.

  16. Toxic hazards of underground excavation

    SciTech Connect

    Smith, R.; Chitnis, V.; Damasian, M.; Lemm, M.; Popplesdorf, N.; Ryan, T.; Saban, C.; Cohen, J.; Smith, C.; Ciminesi, F.

    1982-09-01

    Inadvertent intrusion into natural or man-made toxic or hazardous material deposits as a consequence of activities such as mining, excavation or tunnelling has resulted in numerous deaths and injuries in this country. This study is a preliminary investigation to identify and document instances of such fatal or injurious intrusion. An objective is to provide useful insights and information related to potential hazards due to future intrusion into underground radioactive-waste-disposal facilities. The methodology used in this study includes literature review and correspondence with appropriate government agencies and organizations. Key categories of intrusion hazards are asphyxiation, methane, hydrogen sulfide, silica and asbestos, naturally occurring radionuclides, and various mine or waste dump related hazards.

  17. Portable sensor for hazardous waste

    SciTech Connect

    Piper, L.G.; Fraser, M.E.; Davis, S.J.

    1995-10-01

    We are beginning the second phase of a three and a half year program designed to develop a portable monitor for sensitive hazardous waste detection. The ultimate goal of the program is to develop our concept to the prototype instrument level. Our monitor will be a compact, portable instrument that will allow real-time, in situ, monitoring of hazardous wastes. This instrument will be able to provide the means for rapid field screening of hazardous waste sites to map the areas of greatest contamination. Remediation efforts can then focus on these areas. Further, our instrument can show whether cleanup technologies are successful at reducing hazardous materials concentrations below regulated levels, and will provide feedback to allow changes in remediation operations, if necessary, to enhance their efficacy.

  18. Transportation of Hazardous Evidentiary Material.

    SciTech Connect

    Osborn, Douglas.

    2005-06-01

    This document describes the specimen and transportation containers currently available for use with hazardous and infectious materials. A detailed comparison of advantages, disadvantages, and costs of the different technologies is included. Short- and long-term recommendations are also provided.3 DraftDraftDraftExecutive SummaryThe Federal Bureau of Investigation's Hazardous Materials Response Unit currently has hazardous material transport containers for shipping 1-quart paint cans and small amounts of contaminated forensic evidence, but the containers may not be able to maintain their integrity under accident conditions or for some types of hazardous materials. This report provides guidance and recommendations on the availability of packages for the safe and secure transport of evidence consisting of or contaminated with hazardous chemicals or infectious materials. Only non-bulk containers were considered because these are appropriate for transport on small aircraft. This report will addresses packaging and transportation concerns for Hazardous Classes 3, 4, 5, 6, 8, and 9 materials. If the evidence is known or suspected of belonging to one of these Hazardous Classes, it must be packaged in accordance with the provisions of 49 CFR Part 173. The anthrax scare of several years ago, and less well publicized incidents involving unknown and uncharacterized substances, has required that suspicious substances be sent to appropriate analytical laboratories for analysis and characterization. Transportation of potentially hazardous or infectious material to an appropriate analytical laboratory requires transport containers that maintain both the biological and chemical integrity of the substance in question. As a rule, only relatively small quantities will be available for analysis. Appropriate transportation packaging is needed that will maintain the integrity of the substance, will not allow biological alteration, will not react chemically with the substance being

  19. FIRE HAZARDS ANALYSIS - BUSTED BUTTE

    SciTech Connect

    R. Longwell; J. Keifer; S. Goodin

    2001-01-22

    The purpose of this fire hazards analysis (FHA) is to assess the risk from fire within individual fire areas at the Busted Butte Test Facility and to ascertain whether the DOE fire safety objectives are met. The objective, identified in DOE Order 420.1, Section 4.2, is to establish requirements for a comprehensive fire and related hazards protection program for facilities sufficient to minimize the potential for: (1) The occurrence of a fire related event. (2) A fire that causes an unacceptable on-site or off-site release of hazardous or radiological material that will threaten the health and safety of employees. (3) Vital DOE programs suffering unacceptable interruptions as a result of fire and related hazards. (4) Property losses from a fire and related events exceeding limits established by DOE. Critical process controls and safety class systems being damaged as a result of a fire and related events.

  20. Exporting hazards to developing countries.

    PubMed

    Menkes, D B

    1998-01-01

    The health of people in developing countries is threatened by the importation of hazardous products, wastes and industrial processes from the developed world. Combating this menace is a facet of environmental protection and management of the planet's resources. PMID:10050169

  1. MGR External Events Hazards Analysis

    SciTech Connect

    L. Booth

    1999-11-06

    The purpose and objective of this analysis is to apply an external events Hazards Analysis (HA) to the License Application Design Selection Enhanced Design Alternative 11 [(LADS EDA II design (Reference 8.32))]. The output of the HA is called a Hazards List (HL). This analysis supersedes the external hazards portion of Rev. 00 of the PHA (Reference 8.1). The PHA for internal events will also be updated to the LADS EDA II design but under a separate analysis. Like the PHA methodology, the HA methodology provides a systematic method to identify potential hazards during the 100-year Monitored Geologic Repository (MGR) operating period updated to reflect the EDA II design. The resulting events on the HL are candidates that may have potential radiological consequences as determined during Design Basis Events (DBEs) analyses. Therefore, the HL that results from this analysis will undergo further screening and analysis based on the criteria that apply during the performance of DBE analyses.

  2. Natural Hazards - A National Threat

    USGS Publications Warehouse

    Geological Survey, U.S.

    2007-01-01

    The USGS Role in Reducing Disaster Losses -- In the United States each year, natural hazards cause hundreds of deaths and cost billions of dollars in disaster aid, disruption of commerce, and destruction of homes and critical infrastructure. Although the number of lives lost to natural hazards each year generally has declined, the economic cost of major disaster response and recovery continues to rise. Each decade, property damage from natural hazards events doubles or triples. The United States is second only to Japan in economic damages resulting from natural disasters. A major goal of the U.S. Geological Survey (USGS) is to reduce the vulnerability of the people and areas most at risk from natural hazards. Working with partners throughout all sectors of society, the USGS provides information, products, and knowledge to help build more resilient communities.

  3. Hazardous Wastes--New Developments.

    ERIC Educational Resources Information Center

    Rogers, Harvey W.

    1979-01-01

    The need for effective disposal of hazardous medical and pathological wastes is discussed and the results of a test of five different models of incinerators in disposing of such wastes is presented. (MJB)

  4. Sex ratios in pheasant research and management

    USGS Publications Warehouse

    Dale, F.H.

    1952-01-01

    Sex ratios are of primary importance in interpretation of extensive studies of pheasant populations. They are necessary for converting crowing-cock indices to population estimates even where annual trends are to be studied in the same area. Reliability of population estimates from hunting season kill of pheasants suffers primarily from inability to estimate sex ratios accurately. Fall sex ratio is an index to production and where adult sex ratios are divergent can serve as a good check on production per hen. Age ratios of cocks cannot be interpreted directly as an index of productivity, even within the boundaries of one state, unless adult sex ratios are known. The relationship between observed and actual sex ratio varies significantly from season to season and according to the method of observation. In view of their importance in population studies and the lack of reliability of present methods, it is believed that intensive studies on techniques for obtaining sex ratios are a major need in pheasant research.

  5. The Role of Environmental Hazard in Mothers' Beliefs about Appropriate Supervision

    ERIC Educational Resources Information Center

    Damashek, Amy; Borduin, Charles; Ronis, Scott

    2014-01-01

    Understanding factors that influence mothers' beliefs about appropriate levels of supervision for their children may assist in efforts to reduce child injury rates. This study examined the interaction of child (i.e. age, gender, and injury risk behavior) and maternal perception of environmental hazard (i.e. hazard level, injury likelihood,…

  6. Ocular hazards of light

    NASA Technical Reports Server (NTRS)

    Sliney, David H.

    1994-01-01

    The eye is protected against bright light by the natural aversion response to viewing bright light sources. The aversion response normally protects the eye against injury from viewing bright light sources such as the sun, arc lamps and welding arcs, since this aversion limits the duration of exposure to a fraction of a second (about 0.25 s). The principal retinal hazard resulting from viewing bright light sources is photoretinitis, e.g., solar retinitis with an accompanying scotoma which results from staring at the sun. Solar retinitis was once referred to as 'eclipse blindness' and associated 'retinal burn'. Only in recent years has it become clear that photoretinitis results from a photochemical injury mechanism following exposure of the retina to shorter wavelengths in the visible spectrum, i.e., violet and blue light. Prior to conclusive animal experiments at that time, it was thought to be a thermal injury mechanism. However, it has been shown conclusively that an intense exposure to short-wavelength light (hereafter referred to as 'blue light') can cause retinal injury. The product of the dose-rate and the exposure duration always must result in the same exposure dose (in joules-per-square centimeter at the retina) to produce a threshold injury. Blue-light retinal injury (photoretinitis) can result from viewing either an extremely bright light for a short time, or a less bright light for longer exposure periods. This characteristic of photochemical injury mechanisms is termed reciprocity and helps to distinguish these effects from thermal burns, where heat conduction requires a very intense exposure within seconds to cause a retinal coagulation otherwise, surrounding tissue conducts the heat away from the retinal image. Injury thresholds for acute injury in experimental animals for both corneal and retinal effects have been corroborated for the human eye from accident data. Occupational safety limits for exposure to UVR and bright light are based upon this

  7. Preliminary hazards analysis -- vitrification process

    SciTech Connect

    Coordes, D.; Ruggieri, M.; Russell, J.; TenBrook, W.; Yimbo, P.

    1994-06-01

    This paper presents a Preliminary Hazards Analysis (PHA) for mixed waste vitrification by joule heating. The purpose of performing a PHA is to establish an initial hazard categorization for a DOE nuclear facility and to identify those processes and structures which may have an impact on or be important to safety. The PHA is typically performed during and provides input to project conceptual design. The PHA is then followed by a Preliminary Safety Analysis Report (PSAR) performed during Title 1 and 2 design. The PSAR then leads to performance of the Final Safety Analysis Report performed during the facility`s construction and testing. It should be completed before routine operation of the facility commences. This PHA addresses the first four chapters of the safety analysis process, in accordance with the requirements of DOE Safety Guidelines in SG 830.110. The hazards associated with vitrification processes are evaluated using standard safety analysis methods which include: identification of credible potential hazardous energy sources; identification of preventative features of the facility or system; identification of mitigative features; and analyses of credible hazards. Maximal facility inventories of radioactive and hazardous materials are postulated to evaluate worst case accident consequences. These inventories were based on DOE-STD-1027-92 guidance and the surrogate waste streams defined by Mayberry, et al. Radiological assessments indicate that a facility, depending on the radioactive material inventory, may be an exempt, Category 3, or Category 2 facility. The calculated impacts would result in no significant impact to offsite personnel or the environment. Hazardous materials assessment indicates that a Mixed Waste Vitrification facility will be a Low Hazard facility having minimal impacts to offsite personnel and the environment.

  8. USGS National Seismic Hazard Maps

    USGS Publications Warehouse

    Frankel, A.D.; Mueller, C.S.; Barnhard, T.P.; Leyendecker, E.V.; Wesson, R.L.; Harmsen, S.C.; Klein, F.W.; Perkins, D.M.; Dickman, N.C.; Hanson, S.L.; Hopper, M.G.

    2000-01-01

    The U.S. Geological Survey (USGS) recently completed new probabilistic seismic hazard maps for the United States, including Alaska and Hawaii. These hazard maps form the basis of the probabilistic component of the design maps used in the 1997 edition of the NEHRP Recommended Provisions for Seismic Regulations for New Buildings and Other Structures, prepared by the Building Seismic Safety Council arid published by FEMA. The hazard maps depict peak horizontal ground acceleration and spectral response at 0.2, 0.3, and 1.0 sec periods, with 10%, 5%, and 2% probabilities of exceedance in 50 years, corresponding to return times of about 500, 1000, and 2500 years, respectively. In this paper we outline the methodology used to construct the hazard maps. There are three basic components to the maps. First, we use spatially smoothed historic seismicity as one portion of the hazard calculation. In this model, we apply the general observation that moderate and large earthquakes tend to occur near areas of previous small or moderate events, with some notable exceptions. Second, we consider large background source zones based on broad geologic criteria to quantify hazard in areas with little or no historic seismicity, but with the potential for generating large events. Third, we include the hazard from specific fault sources. We use about 450 faults in the western United States (WUS) and derive recurrence times from either geologic slip rates or the dating of pre-historic earthquakes from trenching of faults or other paleoseismic methods. Recurrence estimates for large earthquakes in New Madrid and Charleston, South Carolina, were taken from recent paleoliquefaction studies. We used logic trees to incorporate different seismicity models, fault recurrence models, Cascadia great earthquake scenarios, and ground-motion attenuation relations. We present disaggregation plots showing the contribution to hazard at four cities from potential earthquakes with various magnitudes and

  9. Progress in NTHMP Hazard Assessment

    USGS Publications Warehouse

    Gonzalez, F.I.; Titov, V.V.; Mofjeld, H.O.; Venturato, A.J.; Simmons, R.S.; Hansen, R.; Combellick, R.; Eisner, R.K.; Hoirup, D.F.; Yanagi, B.S.; Yong, S.; Darienzo, M.; Priest, G.R.; Crawford, G.L.; Walsh, T.J.

    2005-01-01

    The Hazard Assessment component of the U.S. National Tsunami Hazard Mitigation Program has completed 22 modeling efforts covering 113 coastal communities with an estimated population of 1.2 million residents that are at risk. Twenty-three evacuation maps have also been completed. Important improvements in organizational structure have been made with the addition of two State geotechnical agency representatives to Steering Group membership, and progress has been made on other improvements suggested by program reviewers. ?? Springer 2005.

  10. Effects of Smoking on Menopausal Age: Results From the Korea National Health and Nutrition Examination Survey, 2007 to 2012

    PubMed Central

    Yang, Hee Jung; Suh, Pae Sun; Kim, Soo Jeong; Lee, Soon Young

    2015-01-01

    Objectives: Decreased fertility and impaired health owing to early menopause are significant health issues. Smoking is a modifiable health-related behavior that influences menopausal age. We investigated the effects of smoking-associated characteristics on menopausal age in Korean women. Methods: This study used data from the Korea National Health and Nutrition Examination Survey from 2007 to 2012. Menopausal age in relation to smoking was analyzed as a Kaplan-Meier survival curve for 11 510 women (aged 30 to 65 years). The risk of entering menopause and experiencing early menopause (before age 48) related to smoking were assessed using a Cox proportional hazards model. Results: The menopausal age among smokers was 0.75 years lower than that among non-smokers (p<0.001). The results of the Cox proportional hazards model showed pre-correction and post-correction risk ratios for entering menopause related to smoking of 1.26 (95% confidence interval [CI], 1.09 to 1.46) and 1.27 (95% CI, 1.10 to 1.47), respectively, and pre-correction and post-correction risk ratios for experiencing early menopause related to smoking of 1.36 (95% CI, 1.03 to 1.80) and 1.40 (95% CI, 1.05 to 1.85), respectively. Conclusions: Smokers reached menopause earlier than non-smokers, and their risk for experiencing early menopause was higher. PMID:26265667

  11. Age-adjusted recipient pretransplantation telomere length and treatment-related mortality after hematopoietic stem cell transplantation

    PubMed Central

    Calado, Rodrigo T.; Busson, Marc; Abrams, Jeffrey; Adoui, Nadir; Robin, Marie; Larghero, Jérôme; Dhedin, Nathalie; Xhaard, Alienor; Clave, Emmanuel; Charron, Dominique; Toubert, Antoine; Loiseau, Pascale; Socié, Gérard; Young, Neal S.

    2012-01-01

    Telomere attrition induces cell senescence and apoptosis. We hypothesized that age-adjusted pretransplantation telomere length might predict treatment-related mortality (TRM) after hematopoietic stem cell transplantation (HSCT). Between 2000 and 2005, 178 consecutive patients underwent HSCT from HLA-identical sibling donors after myeloablative conditioning regimens, mainly for hematologic malignancies (n = 153). Blood lymphocytes' telomere length was measured by real-time quantitative PCR before HSCT. Age-adjusted pretransplantation telomere lengths were analyzed for correlation with clinical outcomes. After age adjustment, patients' telomere-length distribution was similar among all 4 quartiles except for disease stage. There was no correlation between telomere length and engraftment, GVHD, or relapse. The overall survival was 62% at 5 years (95% confidence interval [CI], 54-70). After a median follow-up of 51 months (range, 1-121 months), 43 patients died because of TRM. The TRM rate inversely correlated with telomere length. TRM in patients in the first (lowest telomere length) quartile was significantly higher than in patients with longer telomeres (P = .017). In multivariate analysis, recipients' age (hazard ratio, 1.1; 95% CI, .0-1.1; P = .0001) and age-adjusted telomere length (hazard ratio, 0.4; 95% CI; 0.2-0.8; P = .01) were independently associated with TRM. In conclusion, age-adjusted recipients' telomere length is an independent biologic marker of TRM after HSCT. PMID:22948043

  12. Behaviour of Recycled Coarse Aggregate Concrete: Age and Successive Recycling

    NASA Astrophysics Data System (ADS)

    Sahoo, Kirtikanta; Pathappilly, Robin Davis; Sarkar, Pradip

    2016-06-01

    Recycled Coarse Aggregate (RCA) concrete construction technique can be called as `green concrete', as it minimizes the environmental hazard of the concrete waste disposal. Indian standard recommends target mean compressive strength of the conventional concrete in terms of water cement ratio ( w/ c). The present work is an attempt to study the behaviour of RCA concrete from two samples of parent concrete having different age group with regard to the relationship of compressive strength with water cement ratios. Number of recycling may influence the mechanical properties of RCA concrete. The influence of age and successive recycling on the properties such as capillary water absorption, drying shrinkage strain, air content, flexural strength and tensile splitting strength of the RCA concrete are examined. The relationship between compressive strength at different w/ c ratios obtained experimentally is investigated for the two parameters such as age of parent concrete and successive recycling. The recycled concrete using older recycled aggregate shows poor quality. While the compressive strength reduces with successive recycling gradually, the capillary water absorption increases abruptly, which leads to the conclusion that further recycling may not be advisable.

  13. Probabilistic analysis of tsunami hazards

    USGS Publications Warehouse

    Geist, E.L.; Parsons, T.

    2006-01-01

    Determining the likelihood of a disaster is a key component of any comprehensive hazard assessment. This is particularly true for tsunamis, even though most tsunami hazard assessments have in the past relied on scenario or deterministic type models. We discuss probabilistic tsunami hazard analysis (PTHA) from the standpoint of integrating computational methods with empirical analysis of past tsunami runup. PTHA is derived from probabilistic seismic hazard analysis (PSHA), with the main difference being that PTHA must account for far-field sources. The computational methods rely on numerical tsunami propagation models rather than empirical attenuation relationships as in PSHA in determining ground motions. Because a number of source parameters affect local tsunami runup height, PTHA can become complex and computationally intensive. Empirical analysis can function in one of two ways, depending on the length and completeness of the tsunami catalog. For site-specific studies where there is sufficient tsunami runup data available, hazard curves can primarily be derived from empirical analysis, with computational methods used to highlight deficiencies in the tsunami catalog. For region-wide analyses and sites where there are little to no tsunami data, a computationally based method such as Monte Carlo simulation is the primary method to establish tsunami hazards. Two case studies that describe how computational and empirical methods can be integrated are presented for Acapulco, Mexico (site-specific) and the U.S. Pacific Northwest coastline (region-wide analysis).

  14. Directional gear ratio transmissions

    NASA Technical Reports Server (NTRS)

    Lafever, A. E. (Inventor)

    1984-01-01

    Epicyclic gear transmissions which transmit output at a gear ratio dependent only upon the input's direction are considered. A transmission housing envelops two epicyclic gear assemblies, and has shafts extending from it. One shaft is attached to a sun gear within the first epicyclic gear assembly. Planet gears are held symmetrically about the sun gear by a planet gear carrier and are in mesh with both the sun gear and a ring gear. Two unidirectional clutches restrict rotation of the first planet gear carrier and ring gear to one direction. A connecting shaft drives a second sun gear at the same speed and direction as the first planet gear carrier while a connecting portion drives a second planet gear carrier at the same speed and direction as the first ring gear. The transmission's output is then transmitted by the second ring gear to the second shaft. Input is transmitted at a higher gear ratio and lower speed for all inputs in the first direction than in the opposite direction.

  15. GIS Grid and CWS-based assessment of vulnerability to debris flow hazards in the upper reaches of Min River, China

    NASA Astrophysics Data System (ADS)

    Ding, Mingtao; Hübl, Johannes; Fuchs, Sven

    2014-05-01

    Based on conceptual models of vulnerability assessment for mountain hazards, this paper aims to improve a quantitative assessment model for regional vulnerability by a detailed analysis of the relation between and among vulnerability (V), exposure (E), social coping capacity (C) and resilience (Re) with the expression of V = E(1-° C+Re- 2). Taking the mountain settlements in the upper reaches of Min River, China, as an example and ArcGIS 9.3 as the platform, we applied the technology of GIS Grid and the method of Contributing Weight Superposition (CWS) to establish both a model and a system for the vulnerability assessment of elements at risk. The latter consists of 13 index factors including population, economics and road densities, building and farmland coverage, hazard-affected areas, a monitoring coefficient to take into account early warning measures, the urbanization rate, GDP per capita, and labor aged population ratio. Accordingly, a debris-flow hazard vulnerability zoning map has been obtained and the assessment results had shown that the distribution of high and comparatively high vulnerability zones, where economic activities are the most intensive, had a close correlation to the river geometry and geomorphology and population activities. Such results correspond well with loss data in the region, proving the reasonability and feasibility of assessment methods in this paper. The results thus may serve as the pertinent guidance for settlement relocation, population distribution readjustment, and management to prevent and reduce hazards in the upper reaches of Min River.

  16. Evaluation of occupational hazards in foundries.

    PubMed

    Zakaria, Adel M; Noweir, Kamal H; El-Maghrabi, Gamal

    2005-01-01

    The working environment of foundries is hazardous and characterized by multiple simultaneous chemical, physical and mechanical hazards exposure, which would lead to injuries of foundry workers. The aim of the present work is to evaluate occupational hazards in four foundries, two in Alexandria: El Nasr and Ramsis, and two in Behira: Misr Spinning and Weaving and Misr Rayon companies. Levels of total and respirable dust, free silica % in total dust and lead concentration in total and respirable dust; NO2, SO2 and CO concentrations; noise and heat stress levels have been determined in the present work. Occupational injuries data were analyzed in a three years period from 1998 to 2000. The results of the present work revealed; 1. The levels of total dust and respirable dust exceeded the threshold limit values at knockout and cleaning operations at El Nasr Company. 2. Free silica percentage exceeded permissible levels in all operations except pouring in El Nasr Company. 3. CO levels in Misr Spinning and Weaving Company were higher than threshold levels. 4. Noise levels in knockout and cleaning operations at the four companies were exceeding the threshold limit values. 5. Heat stress levels in melting and pouring operations in El Nasr and in pouring operation in Ramsis Company were higher than the maximum permissible levels. 6. The age group 31-40 years has recorded the highest average incidence rate of injuries of age groups (P<0.01). 7. Lower extremities and higher extremities have recorded the highest average incidence rate in the four companies (P<0.001-P<0.01 respectively). 8. Transportation and lifting was the main cause of injury in the four companies (P<0.05). 9. Faulty action and striking against was the main mean of injury in the four companies (P<0.01). 10. Ramsis Company has the highest average incidence rate in almost all injuries parameters and indices (frequency rate and severity rate) (P<0.05-P<0.001). The present work is a massive survey, which

  17. Seismic Hazard in Haiti: A Geologic Perspective

    NASA Astrophysics Data System (ADS)

    Prentice, C. S.; Crone, A. J.; Gold, R. D.; Briggs, R. W.; Narcisse, R.

    2012-12-01

    The catastrophic M 7.0 earthquake that occurred in Haiti on 12 January 2010 highlighted the hazard associated with the Caribbean-North American plate boundary in Hispaniola. Detailed analysis and modeling of geologic, geodetic, and seismologic data showed that most of the moment release occurred on a previously unidentified, north-dipping, blind thrust fault (now named the Léogâne fault), which is north of the plate-bounding, left-lateral Enriquillo-Plantain Garden fault (EPGF). The result that the Léogâne fault was the source of the 2010 earthquake implies that the EPGF remains a significant hazard and raises the question of other potential seismic sources near Port-au-Prince (PaP). Following the earthquake, we mapped Quaternary traces of the EPGF in the field using satellite imagery, aerial photography, and LiDAR data. We identified three paleoseismic study sites along the EPGF: the Jean-Jean and Marianne sites southwest of PaP along the Momance section of the EPGF and the Riviére Grise site southeast of PaP along the Dumay section. Trenches at the Jean-Jean site show fault strands breaking nearly to the ground surface, but that did not move in the 2010 earthquake. We collected radiocarbon samples from faulted strata that we anticipate will provide constraints on the age of the most recent surface rupture. We also identified a buried channel deposit that is left-laterally offset a minimum of 3 m, and collected radiocarbon samples to constrain its age. In a natural stream cut at the Marianne site, we documented three colluvial wedges, and collected samples for optically stimulated luminescence (OSL) dating that we anticipate will provide age constraints on the three most recent earthquakes. At Riviére Grise we documented evidence for three surface ruptures in a fluvial terrace deposit, and collected OSL samples to constrain their ages. Our preliminary geomorphic analysis of a belt of low hills north of the EPGF and east of PaP suggests that these hills are

  18. Partner age-disparity and HIV incidence risk for older women in rural South Africa

    PubMed Central

    Harling, Guy; Newell, Marie-Louise; Tanser, Frank; Bärnighausen, Till

    2014-01-01

    While sexual partner age disparity is frequently considered as a potential risk factor for HIV amongst young women in Africa, no research has addressed this question amongst older women. Our aim was thus to determine whether sex partner age disparity was associated with subsequent HIV acquisition in women aged over 30. Methods To achieve this aim we conducted a quantitative analysis of a population-based, open cohort of women in rural KwaZulu-Natal, South Africa (n=1,737) using Cox proportional hazards models. Results As partner age rose, HIV acquisition risk fell significantly: compared to a same-aged partner, a five-year older partner was associated with a one-third reduction (hazard ratio [HR]: 0.63, 95%CI: 0.52–0.76) and a ten-year older partner with a one-half reduction (HR: 0.48, 95%CI: 0.35–0.67). This result was neither confounded nor effect-modified by women’s age or socio-demographic factors. Conclusions These findings suggest that existing HIV risk-reduction campaigns warning young women about partnering with older men may be inappropriate for older women. HIV prevention strategies interventions specifically tailored to older women are needed. PMID:25670473

  19. Peak power ratio generator

    DOEpatents

    Moyer, R.D.

    A peak power ratio generator is described for measuring, in combination with a conventional power meter, the peak power level of extremely narrow pulses in the gigahertz radio frequency bands. The present invention in a preferred embodiment utilizes a tunnel diode and a back diode combination in a detector circuit as the only high speed elements. The high speed tunnel diode provides a bistable signal and serves as a memory device of the input pulses for the remaining, slower components. A hybrid digital and analog loop maintains the peak power level of a reference channel at a known amount. Thus, by measuring the average power levels of the reference signal and the source signal, the peak power level of the source signal can be determined.

  20. Peak power ratio generator

    DOEpatents

    Moyer, Robert D.

    1985-01-01

    A peak power ratio generator is described for measuring, in combination with a conventional power meter, the peak power level of extremely narrow pulses in the gigahertz radio frequency bands. The present invention in a preferred embodiment utilizes a tunnel diode and a back diode combination in a detector circuit as the only high speed elements. The high speed tunnel diode provides a bistable signal and serves as a memory device of the input pulses for the remaining, slower components. A hybrid digital and analog loop maintains the peak power level of a reference channel at a known amount. Thus, by measuring the average power levels of the reference signal and the source signal, the peak power level of the source signal can be determined.

  1. Risk of Malignant Neoplasms of Kidney and Bladder in a Cohort Study of the Diabetic Population in Taiwan With Age, Sex, and Geographic Area Stratifications.

    PubMed

    Chen, Hua-Fen; Chen, Shwe-Winn; Chang, Ya-Hui; Li, Chung-Yi

    2015-09-01

    Diabetes has been reported to increase the risk of malignant neoplasms of kidney and bladder, but the studies' results are still inconclusive. Age, sex, and geographical area-specific incidence and relative risks of above neoplasms are also scarce in the literature. We prospectively investigated the age, sex, geographical area-specific incidence and relative risks of kidney and bladder neoplasms in diabetic population of Taiwan. Diabetic patients (n = 615,532) and age- and sex-matched controls (n = 614,871) were linked to inpatient claims (2000-2008) to identify the admissions for malignant neoplasm of kidney (International Classification of Diagnosis, 9th version, Clinical Modification: 189) and bladder (International Classification of Diagnosis, 9th version, Clinical Modification: 188). The person-year approach with Poisson assumption was used to evaluate the incidence density. We also estimated the age, sex, and geographical area-specific relative risks of above malignancy in relation to diabetes with Cox proportional hazard regression model. The overall incidence density of malignant neoplasm of kidney for diabetic men and women were 3.87 and 4.28 per 10,000 patient-years, respectively; the corresponding figures for malignant neoplasm of bladder were 5.73 and 3.25 per 10,000 patient-years. Compared with the controls, diabetic men were at significantly increased hazards of kidney (covariate adjusted hazard ratio [aHR]: 1.31, 95% confidence interval [CI] 1.18-1.46) and bladder aHR: 1.13, 95% CI 1.04-1.23). Diabetic women, on the contrary, only experienced significantly elevated hazard of kidney neoplasm (aHR: 1.14, 95% CI 1.04-1.26). Diabetic men aged >65 years showed the most significantly increased hazard of developing neoplasm of kidney (aHR: 1.40) and bladder (aHR: 1.13). The most significantly increased hazard of kidney neoplasm was noted for women diabetic patients aged >65 years. There was also a significant interactive effect of geographic area

  2. 14 CFR 437.29 - Hazard analysis.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Hazard analysis. 437.29 Section 437.29... Documentation § 437.29 Hazard analysis. (a) An applicant must perform a hazard analysis that complies with § 437.55(a). (b) An applicant must provide to the FAA all the results of each step of the hazard...

  3. 14 CFR 437.29 - Hazard analysis.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Hazard analysis. 437.29 Section 437.29... Documentation § 437.29 Hazard analysis. (a) An applicant must perform a hazard analysis that complies with § 437.55(a). (b) An applicant must provide to the FAA all the results of each step of the hazard...

  4. 14 CFR 437.29 - Hazard analysis.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Hazard analysis. 437.29 Section 437.29... Documentation § 437.29 Hazard analysis. (a) An applicant must perform a hazard analysis that complies with § 437.55(a). (b) An applicant must provide to the FAA all the results of each step of the hazard...

  5. 14 CFR 437.29 - Hazard analysis.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Hazard analysis. 437.29 Section 437.29... Documentation § 437.29 Hazard analysis. (a) An applicant must perform a hazard analysis that complies with § 437.55(a). (b) An applicant must provide to the FAA all the results of each step of the hazard...

  6. 16 CFR 1500.5 - Hazardous mixtures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Hazardous mixtures. 1500.5 Section 1500.5... HAZARDOUS SUBSTANCES AND ARTICLES; ADMINISTRATION AND ENFORCEMENT REGULATIONS § 1500.5 Hazardous mixtures. For a mixture of substances, the determination of whether the mixture is a “hazardous substance”...

  7. 16 CFR 1500.5 - Hazardous mixtures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Hazardous mixtures. 1500.5 Section 1500.5... HAZARDOUS SUBSTANCES AND ARTICLES; ADMINISTRATION AND ENFORCEMENT REGULATIONS § 1500.5 Hazardous mixtures. For a mixture of substances, the determination of whether the mixture is a “hazardous substance”...

  8. 16 CFR 1500.5 - Hazardous mixtures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Hazardous mixtures. 1500.5 Section 1500.5... HAZARDOUS SUBSTANCES AND ARTICLES; ADMINISTRATION AND ENFORCEMENT REGULATIONS § 1500.5 Hazardous mixtures. For a mixture of substances, the determination of whether the mixture is a “hazardous substance”...

  9. 16 CFR 1500.5 - Hazardous mixtures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Hazardous mixtures. 1500.5 Section 1500.5... HAZARDOUS SUBSTANCES AND ARTICLES; ADMINISTRATION AND ENFORCEMENT REGULATIONS § 1500.5 Hazardous mixtures. For a mixture of substances, the determination of whether the mixture is a “hazardous substance”...

  10. 16 CFR 1500.5 - Hazardous mixtures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Hazardous mixtures. 1500.5 Section 1500.5... HAZARDOUS SUBSTANCES AND ARTICLES; ADMINISTRATION AND ENFORCEMENT REGULATIONS § 1500.5 Hazardous mixtures. For a mixture of substances, the determination of whether the mixture is a “hazardous substance”...

  11. BEHAVIORAL HAZARD IN HEALTH INSURANCE*

    PubMed Central

    Baicker, Katherine; Mullainathan, Sendhil; Schwartzstein, Joshua

    2015-01-01

    A fundamental implication of standard moral hazard models is overuse of low-value medical care because copays are lower than costs. In these models, the demand curve alone can be used to make welfare statements, a fact relied on by much empirical work. There is ample evidence, though, that people misuse care for a different reason: mistakes, or “behavioral hazard.” Much high-value care is underused even when patient costs are low, and some useless care is bought even when patients face the full cost. In the presence of behavioral hazard, welfare calculations using only the demand curve can be off by orders of magnitude or even be the wrong sign. We derive optimal copay formulas that incorporate both moral and behavioral hazard, providing a theoretical foundation for value-based insurance design and a way to interpret behavioral “nudges.” Once behavioral hazard is taken into account, health insurance can do more than just provide financial protection—it can also improve health care efficiency. PMID:23930294

  12. Hydrothermal Liquefaction Treatment Preliminary Hazard Analysis Report

    SciTech Connect

    Lowry, Peter P.; Wagner, Katie A.

    2015-08-31

    A preliminary hazard assessment was completed during February 2015 to evaluate the conceptual design of the modular hydrothermal liquefaction treatment system. The hazard assessment was performed in 2 stages. An initial assessment utilizing Hazard Identification and Preliminary Hazards Analysis (PHA) techniques identified areas with significant or unique hazards (process safety-related hazards) that fall outside of the normal operating envelope of PNNL and warranted additional analysis. The subsequent assessment was based on a qualitative What-If analysis. This analysis was augmented, as necessary, by additional quantitative analysis for scenarios involving a release of hazardous material or energy with the potential for affecting the public.

  13. High-Ratio Gear Train

    NASA Technical Reports Server (NTRS)

    Lefever, A. E.

    1982-01-01

    Proposed arrangement of two connected planetary differentials results in gear ratio many times that obtainable in conventional series gear assembly of comparable size. Ratios of several thousand would present no special problems. Selection of many different ratios is available with substantially similar gear diameters. Very high gear ratios would be obtained from small mechanism.

  14. On the variability of alligator sex ratios

    USGS Publications Warehouse

    Nichols, J.D.; Chabreck, R.H.

    1980-01-01

    Samples of alligators from wild and 'farm' populations exhibited disproportionate sex ratios. Males predominated among young alligators from wild populations, whereas females were much more abundant than males in the farm population, where resources were superabundant. These results and other considerations lead us to hypothesize that environmental factors influence sex determination in alligators. During favorable environmental conditions natural selection is expected to favor a preponderance of the sex whose individuals exhibit the greater environmentally associated variation in relative fitness. We hypothesize that environmentally associated variation in age at sexual maturity of females produces sufficient variation in relative fitness of females to result in selection for low sex ratios during periods of resource abundance.

  15. Ensemble of ground subsidence hazard maps using fuzzy logic

    NASA Astrophysics Data System (ADS)

    Park, Inhye; Lee, Jiyeong; Saro, Lee

    2014-06-01

    Hazard maps of ground subsidence around abandoned underground coal mines (AUCMs) in Samcheok, Korea, were constructed using fuzzy ensemble techniques and a geographical information system (GIS). To evaluate the factors related to ground subsidence, a spatial database was constructed from topographic, geologic, mine tunnel, land use, groundwater, and ground subsidence maps. Spatial data, topography, geology, and various ground-engineering data for the subsidence area were collected and compiled in a database for mapping ground-subsidence hazard (GSH). The subsidence area was randomly split 70/30 for training and validation of the models. The relationships between the detected ground-subsidence area and the factors were identified and quantified by frequency ratio (FR), logistic regression (LR) and artificial neural network (ANN) models. The relationships were used as factor ratings in the overlay analysis to create ground-subsidence hazard indexes and maps. The three GSH maps were then used as new input factors and integrated using fuzzy-ensemble methods to make better hazard maps. All of the hazard maps were validated by comparison with known subsidence areas that were not used directly in the analysis. As the result, the ensemble model was found to be more effective in terms of prediction accuracy than the individual model.

  16. Variable compression ratio control

    SciTech Connect

    Johnson, K.A.

    1988-04-19

    In a four cycle engine that includes a crankshaft having a plural number of main shaft sections defining the crankshaft rotational axis and a plural number of crank arms defining orbital shaft sections, a plural number of combustion cylinders, a movable piston within each cylinder, each cylinder and its associated piston defining a combustion chamber, a connecting rod connecting each piston to an orbital shaft section of the crankshaft, and a plural number of stationary support walls spaced along the crankshaft axis for absorbing crankshaft forces: the improvement is described comprising means for adjustably supporting the crankshaft on the stationary walls such that the crankshaft rotational axis is adjustable along the piston-cylinder axis for the purpose of varying a resulting engine compression ratio; the adjustable support means comprising a circular cavity in each stationary wall. A circular disk swivably is seated in each cavity, each circular disk having a circular opening therethrough eccentric to the disk center. The crankshaft is arranged so that respective ones of its main shaft sections are located within respective ones of the circular openings; means for rotating each circular disk around its center so that the main shaft sections of the crankshaft are adjusted toward and away from the combustion chamber; a pinion gear on an output end of the crankshaft in axial alignment with and positioned beyond the respective ones of the main shaft sections, and a rotary output gear located about and engaged with teeth extending from the pinion gear.

  17. Household hazardous waste in Massachusetts

    SciTech Connect

    Stanek, E.J. 3d.; Tuthill, R.W.; Willis, C.; Moore, G.S.

    1987-03-01

    Household wastes, when disposed of improperly, are hazardous to health. This paper reports a random digit dial telephone survey of Massachusetts households concerning household hazardous waste (HHW) disposal with a 54% response. Of the automotive oil disposed of by 33% of survey households, 57% was deposited in the ground, sewer, or landfill. Annually by household oil disposal in Massachusetts is estimated to be 8.8 million quarts. Four percent of hazardous waste generated in Massachusetts is from households. Improper disposal makes it a major environmental contaminant. More households (41.5%) in smaller communities disposed of oil compared with 26% of households in larger communities. Paint and pesticides were disposed of by 10% of the households, but were dumped on the ground sewer or landfills more than 90% of the time.

  18. Hazard Communication Project: reference manual

    SciTech Connect

    Not Available

    1989-03-01

    This reference manual covers the following course objectives: to inform employees of their employer's requirements under the OSHA Hazard Communication Standard (29 CFR 1910.1200); to instruct employees on the procedures for obtaining and using information on hazardous materials, including understanding labeling systems and the material safety data sheet (MSDS) information; to provide information on 11 classes of chemicals, including their common uses, potential physical and health hazards, detection methods, and safety measures to follow. There are 14 lessons, ranging in length from 30 minutes to 1 (one) hour. The lessons are contained on 6 disks that are programmed to run on an IBM-compatible PC with an EGA graphics card and monitor. The program will not run on monochrome or CGA systems.

  19. Hazards of solar blue light

    SciTech Connect

    Okuno, Tsutomu

    2008-06-01

    Short-wavelength visible light (blue light) of the Sun has caused retinal damage in people who have stared fixedly at the Sun without adequate protection. The author quantified the blue-light hazard of the Sun according to the International Commission on Non-Ionizing Radiation Protection (ICNIRP) guidelines by measuring the spectral radiance of the Sun. The results showed that the exposure limit for blue light can be easily exceeded when people view the Sun and that the solar blue-light hazard generally increases with solar elevation, which is in accordance with a model of the atmospheric extinction of sunlight. Viewing the Sun can be very hazardous and therefore should be avoided except at very low solar elevations.

  20. Portable sensor for hazardous waste

    SciTech Connect

    Piper, L.G.; Fraser, M.E.; Davis, S.J.

    1995-12-01

    We are beginning the second phase of a three and a half year program designed to develop a portable monitor for sensitive hazardous waste detection. The ultimate goal of the program is to develop our concept to the prototype instrument level. Our monitor will be a compact, portable instrument that will allow real-time, in situ, monitoring of hazardous wastes. Further, our instrument can show whether cleanup technologies are successful at reducing hazardous materials concentrations below regulated levels, and will provide feedback to allow changes in remediation operations, if necessary, to enhance their efficacy. Our approach is to excite atomic and molecular fluorescence by the technique of active nitrogen energy transfer (ANET). The active nitrogen is made in a dielectric-barrier (D-B) discharge in nitrogen at atmospheric pressure. Only a few emission lines or bands are excited for each hazardous species, so spectral resolution requirements are greatly simplified over those of other spectroscopic techniques. The dielectric-barrier discharge is compact, 1 to 2 cm in diameter and 1 to 10 cm long. During the first phase of the program we demonstrated that a variety of hazardous species could be detected by the technique of active nitrogen energy transfer (ANET) excitation of atomic and molecular fluorescence. Species investigated included heavy metals, Hg, Cr, and Se, both chlorinated and non-chlorinated organics, and uranyl compounds. For most of these species we demonstrated sensitivity limits for their detection at parts per billion (ppb) levels. Our principal goals for this second phase of the program are to develop and breadboard test instrument components and to design a prototype instrument suitable for construction and evaluation in the final phase of the program. A secondary goal is to extend the ANET technology to encompass a greater number of hazardous species, primarily additional heavy metals and radionuclides.

  1. 49 CFR 173.2 - Hazardous materials classes and index to hazard class definitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    .... Division No. (if any) Name of class or division 49 CFR reference for definitions None Forbidden materials... 49 Transportation 2 2014-10-01 2014-10-01 false Hazardous materials classes and index to hazard... classes and index to hazard class definitions. The hazard class of a hazardous material is...

  2. Seismic Hazard and Public Safety

    NASA Astrophysics Data System (ADS)

    Marzocchi, Warner

    2013-07-01

    The recent destructive earthquakes in Wenchuan (China), L'Aquila (Italy), Port-au-Prince (Haiti), Christchurch (New Zealand), and Tohoku (Japan) have reignited the discussion over seismic safety. Several scientists [e.g., Stein et al., 2012; Wyss et al., 2012] have questioned the reliability of some seismic hazard maps based on the probabilistic seismic hazard analysis (PSHA)—a widely used probabilistic approach that estimates the likelihood of various levels of ground shaking occurring at a given location in a given future time period—raising an intense discussion on this specific point [Hanks et al., 2012; Frankel, 2013; Stein et al., 2013].

  3. KSC VAB Aeroacoustic Hazard Assessment

    NASA Technical Reports Server (NTRS)

    Oliveira, Justin M.; Yedo, Sabrina; Campbell, Michael D.; Atkinson, Joseph P.

    2010-01-01

    NASA Kennedy Space Center (KSC) carried out an analysis of the effects of aeroacoustics produced by stationary solid rocket motors in processing areas at KSC. In the current paper, attention is directed toward the acoustic effects of a motor burning within the Vehicle Assembly Building (VAB). The analysis was carried out with support from ASRC Aerospace who modeled transmission effects into surrounding facilities. Calculations were done using semi-analytical models for both aeroacoustics and transmission. From the results it was concluded that acoustic hazards in proximity to the source of ignition and plume can be severe; acoustic hazards in the far-field are significantly lower.

  4. Hazardous materials package performance regulations

    SciTech Connect

    Russell, N. A.; Glass, R. E.; McClure, J. D.; Finley, N. C.

    1991-01-01

    This paper discusses a hazardous materials Hazmat Packaging Performance Evaluation (HPPE) project being conducted at Sandia National Laboratories for the US Department of Transportation Research Special Programs Administration (DOT-RSPA) to look at the subset of bulk packagings that are larger than 2000 gallons. The objectives of this project are to evaluate current hazmat specification packagings and develop supporting documentation for determining performance requirements for packagings in excess of 2000 gallons that transport hazardous materials that have been classified as extremely toxic by inhalation (METBI).

  5. Social networking patterns/hazards among teenagers.

    PubMed

    Machold, C; Judge, G; Mavrinac, A; Elliott, J; Murphy, A M; Roche, E

    2012-05-01

    Social Networking Sites (SNSs) have grown substantially, posing new hazards to teenagers. This study aimed to determine general patterns of Internet usage among Irish teenagers aged 11-16 years, and to identify potential hazards, including; bullying, inappropriate contact, overuse, addiction and invasion of users' privacy. A cross-sectional study design was employed to survey students at three Irish secondary schools, with a sample of 474 completing a questionnaire. 202 (44%) (n = 460) accessed the Internet using a shared home computer. Two hours or less were spent online daily by 285(62%), of whom 450 (98%) were unsupervised. 306 (72%) (n = 425) reported frequent usage of SNSs, 403 (95%) of whom were Facebook users. 42 (10%) males and 51 (12%) females experienced bullying online, while 114 (27%) reported inappropriate contact from others. Concerning overuse and the risk of addiction, 140 (33%) felt they accessed SNSs too often. These patterns among Irish teenagers suggest that SNS usage poses significant dangers, which are going largely unaddressed. PMID:22803496

  6. Public Remote Observing of Potentially Hazardous Asteroids

    NASA Astrophysics Data System (ADS)

    Hammergren, M.

    2003-05-01

    Since the mid-1990.s, the Adler Planetarium has engaged in a program of public remote observing using the ARC 3.5-meter telescope at the Apache Point Observatory. The impact on regular science programs is minimized by scheduling the public observing during evening twilight on the first Friday of every month, when the Planetarium is open for extended hours. We have recently begun to observe faint, potentially hazardous near-Earth asteroids for which further astrometry is desired. The observations and initial analyses are performed and displayed in real-time in our CyberSpace electronic gallery before a live audience. Audience participation is useful and is actively encouraged. In particular, the asteroids often are first spotted in sequences of images by a member of the audience. Young children have recovered potentially hazardous asteroids. Further data reduction is accomplished with commercially available software. The program is straightforward in concept and execution, and is accessible to audiences of all ages. Since it unambiguously involves real science, it directly addresses the public understanding of research. We believe this program may be copied easily by other institutions that have remote observing assets.

  7. Social networking patterns/hazards among teenagers.

    PubMed

    Machold, C; Judge, G; Mavrinac, A; Elliott, J; Murphy, A M; Roche, E

    2012-05-01

    Social Networking Sites (SNSs) have grown substantially, posing new hazards to teenagers. This study aimed to determine general patterns of Internet usage among Irish teenagers aged 11-16 years, and to identify potential hazards, including; bullying, inappropriate contact, overuse, addiction and invasion of users' privacy. A cross-sectional study design was employed to survey students at three Irish secondary schools, with a sample of 474 completing a questionnaire. 202 (44%) (n = 460) accessed the Internet using a shared home computer. Two hours or less were spent online daily by 285(62%), of whom 450 (98%) were unsupervised. 306 (72%) (n = 425) reported frequent usage of SNSs, 403 (95%) of whom were Facebook users. 42 (10%) males and 51 (12%) females experienced bullying online, while 114 (27%) reported inappropriate contact from others. Concerning overuse and the risk of addiction, 140 (33%) felt they accessed SNSs too often. These patterns among Irish teenagers suggest that SNS usage poses significant dangers, which are going largely unaddressed.

  8. Serum Dioxin Concentrations and Age at Menopause

    PubMed Central

    Eskenazi, Brenda; Warner, Marcella; Marks, Amy R.; Samuels, Steven; Gerthoux, Pier ario; Vercellini, Paolo; Olive, David L.; Needham, Larry; Patterson, Donald G.; Mocarelli, Paolo

    2005-01-01

    2,3,7,8-Tetrachlorobenzo-p-dioxin (TCDD), a halogenated compound that binds the aryl hydrocarbon receptor, is a by-product of numerous industrial processes including waste incineration. Studies in rats and monkeys suggest that TCDD may affect ovarian function. We examined the relationship of TCDD and age at menopause in a population of women residing near Seveso, Italy, in 1976, at the time of a chemical plant explosion. We included 616 of the women who participated 20 years later in the Seveso Women’s Health Study. All women were premenopausal at the time of the explosion, had TCDD levels measured in serum collected soon after the explosion, and were ≥ 35 years of age at interview. Using proportional hazards modeling, we found a 6% nonsignificant increase in risk of early menopause with a 10-fold increase in serum TCDD. When TCDD levels were categorized, compared with women in the lowest quintile (< 20.4 ppt), women in quintile 2 (20.4–34.2 ppt) had a hazard ratio (HR) of 1.1 (p = 0.77), quintile 3 (34.3–54.1 ppt) had an HR of 1.4 (p = 0.14), quintile 4 (54.2–118 ppt) had an HR of 1.6 (p = 0.10), and quintile 5 (> 118 ppt) had an HR of 1.1 (p = 0.82) for risk of earlier menopause. The trend toward earlier menopause across the first four quintiles is statistically significant (p = 0.04). These results suggest a nonmonotonic dose-related association with increasing risk of earlier menopause up to about 100 ppt TCDD, but not above. PMID:16002373

  9. A health hazard evaluation of pheasant handlers.

    PubMed

    Goldstein, M D; Schwartz, B S; Maccarillo, B; Borbi, M; Tuccillo, R

    1989-05-01

    Motivated by complaints of respiratory symptoms at a large state pheasant breeding farm, an evaluation of the health hazards of pheasant handling was undertaken. Pheasant workers (N = 24) were compared with age-, sex-, and smoking-status-matched controls (N = 23) without occupational or home exposure to birds by a respiratory questionnaire, pulmonary function testing (before and after the season and pre- and post-shift), a number of fungal and chlamydial serology tests, and hypersensitivity immunoprecipitins. Despite a number of important differences in the prevalence of symptoms in the pheasant workers, no differences were found in the results of pulmonary function testing or serology tests. These data suggest that the symptoms were likely because of local irritant effects rather than via immunologic or infectious mechanisms.

  10. The Relative Severity of Single Hazards within a Multi-Hazard Framework

    NASA Astrophysics Data System (ADS)

    Gill, Joel C.; Malamud, Bruce D.

    2013-04-01

    Here we present a description of the relative severity of single hazards within a multi-hazard framework, compiled through examining, quantifying and ranking the extent to which individual hazards trigger or increase the probability of other hazards. Hazards are broken up into six major groupings (geophysical, hydrological, shallow earth processes, atmospheric, biophysical and space), with the interactions for 21 different hazard types examined. These interactions include both one primary hazard triggering a secondary hazard, and one primary hazard increasing the probability of a secondary hazard occurring. We identify, through a wide-ranging review of grey- and peer-review literature, >90 interactions. The number of hazard-type linkages are then summed for each hazard in terms of their influence (the number of times one hazard type triggers another type of hazard, or itself) and their sensitivity (the number of times one hazard type is triggered by other hazard types, or itself). The 21 different hazards are then ranked based on (i) influence and (ii) sensitivity. We found, by quantification and ranking of these hazards, that: (i) The strongest influencers (those triggering the most secondary hazards) are volcanic eruptions, earthquakes and storms, which when taken together trigger almost a third of the possible hazard interactions identified; (ii) The most sensitive hazards (those being triggered by the most primary hazards) are identified to be landslides, volcanic eruptions and floods; (iii) When sensitivity rankings are adjusted to take into account the differential likelihoods of different secondary hazards being triggered, the most sensitive hazards are found to be landslides, floods, earthquakes and ground heave. We believe that by determining the strongest influencing and the most sensitive hazards for specific spatial areas, the allocation of resources for mitigation measures might be done more effectively.

  11. Changing tides: Adaptive monitoring, assessment, and management of pharmaceutical hazards in the environment through time.

    PubMed

    Gaw, Sally; Brooks, Bryan W

    2016-04-01

    Pharmaceuticals are ubiquitous contaminants in aquatic ecosystems. Adaptive monitoring, assessment, and management programs will be required to reduce the environmental hazards of pharmaceuticals of concern. Potentially underappreciated factors that drive the environmental dose of pharmaceuticals include regulatory approvals, marketing campaigns, pharmaceutical subsidies and reimbursement schemes, and societal acceptance. Sales data for 5 common antidepressants (duloxetine [Cymbalta], escitalopram [Lexapro], venlafaxine [Effexor], bupropion [Wellbutrin], and sertraline [Zoloft]) in the United States from 2004 to 2008 were modeled to explore how environmental hazards in aquatic ecosystems changed after patents were obtained or expired. Therapeutic hazard ratios for Effexor and Lexapro did not exceed 1; however, the therapeutic hazard ratio for Zoloft declined whereas the therapeutic hazard ratio for Cymbalta increased as a function of patent protection and sale patterns. These changes in therapeutic hazard ratios highlight the importance of considering current and future drivers of pharmaceutical use when prioritizing pharmaceuticals for water quality monitoring programs. When urban systems receiving discharges of environmental contaminants are examined, water quality efforts should identify, prioritize, and select target analytes presently in commerce for effluent monitoring and surveillance.

  12. Changing tides: Adaptive monitoring, assessment, and management of pharmaceutical hazards in the environment through time.

    PubMed

    Gaw, Sally; Brooks, Bryan W

    2016-04-01

    Pharmaceuticals are ubiquitous contaminants in aquatic ecosystems. Adaptive monitoring, assessment, and management programs will be required to reduce the environmental hazards of pharmaceuticals of concern. Potentially underappreciated factors that drive the environmental dose of pharmaceuticals include regulatory approvals, marketing campaigns, pharmaceutical subsidies and reimbursement schemes, and societal acceptance. Sales data for 5 common antidepressants (duloxetine [Cymbalta], escitalopram [Lexapro], venlafaxine [Effexor], bupropion [Wellbutrin], and sertraline [Zoloft]) in the United States from 2004 to 2008 were modeled to explore how environmental hazards in aquatic ecosystems changed after patents were obtained or expired. Therapeutic hazard ratios for Effexor and Lexapro did not exceed 1; however, the therapeutic hazard ratio for Zoloft declined whereas the therapeutic hazard ratio for Cymbalta increased as a function of patent protection and sale patterns. These changes in therapeutic hazard ratios highlight the importance of considering current and future drivers of pharmaceutical use when prioritizing pharmaceuticals for water quality monitoring programs. When urban systems receiving discharges of environmental contaminants are examined, water quality efforts should identify, prioritize, and select target analytes presently in commerce for effluent monitoring and surveillance. PMID:26412644

  13. Database for potential hazards from future volcanic eruptions in California

    USGS Publications Warehouse

    White, Melissa N.; Ramsey, David W.; Miller, C. Dan

    2011-01-01

    More than 500 volcanic vents have been identified in the State of California. At least 76 of these vents have erupted, some repeatedly, during the past 10,000 yr. Past volcanic activity has ranged in scale and type from small rhyolitic and basaltic eruptions through large catastrophic rhyolitic eruptions. Sooner or later, volcanoes in California will erupt again, and they could have serious impacts on the health and safety of the State's citizens as well as on its economy. This report describes the nature and probable distribution of potentially hazardous volcanic phenomena and their threat to people and property. It includes hazard-zonation maps that show areas relatively likely to be affected by future eruptions in California. This digital release contains information from maps of potential hazards from future volcanic eruptions in the state of California, published as Plate 1 in U.S. Geological Survey Bulletin 1847. The main component of this digital release is a spatial database prepared using geographic information systems (GIS) applications. This release also contains links to files to view or print the map plate, main report text, and accompanying hazard tables from Bulletin 1847. It should be noted that much has been learned about the ages of eruptive events in the State of California since the publication of Bulletin 1847 in 1989. For the most up to date information on the status of California volcanoes, please refer to the U.S. Geological Survey Volcano Hazards Program website.

  14. Constraints on Long-Term Seismic Hazard From Vulnerable Stalagmites

    NASA Astrophysics Data System (ADS)

    Gribovszki, Katalin; Bokelmann, Götz; Mónus, Péter; Tóth, László; Kovács, Károly; Konecny, Pavel; Lednicka, Marketa; Spötl, Christoph; Bednárik, Martin; Brimich, Ladislav; Hegymegi, Erika; Novák, Attila

    2016-04-01

    Earthquakes hit urban centers in Europe infrequently, but occasionally with disastrous effects. Obtaining an unbiased view of seismic hazard (and risk) is therefore very important. In principle, the best way to test Probabilistic Seismic Hazard Assessments (PSHA) is to compare them with observations that are entirely independent of the procedure used to produce PSHA models. Arguably, the most valuable information in this context should be information on long-term hazard, namely maximum intensities (or magnitudes) occurring over time intervals that are at least as long as a seismic cycle. Long-term information can in principle be gained from intact stalagmites in natural caves. These formations survived all earthquakes that have occurred, over thousands of years - depending on the age of the stalagmite. Their "survival" requires that the horizontal ground acceleration has never exceeded a certain critical value within that time period. Here we present such a stalagmite-based case study from the Little Carpathians of Slovakia. A specially shaped, intact and vulnerable stalagmite (IVSTM) in Plavecká priepast cave was examined in 2013. This IVSTM is suitable for estimating the upper limit of horizontal peak ground acceleration generated by pre-historic earthquakes. The approach, used in our study, yields significant new constraints on the seismic hazard, as tectonic structures close to Plavecká priepast cave did not generate strong paleoearthquakes in the last few thousand years. A particular importance of this study results from the seismic hazard of two close-by capitals: Vienna and Bratislava.

  15. A Review of Hazard Anticipation Training Programs for Young Drivers

    PubMed Central

    McDonald, Catherine C.; Goodwin, Arthur H.; Pradhan, Anuj K.; Romoser, Matthew R.E.; Williams, Allan F.

    2015-01-01

    Purpose Poor hazard anticipation skills are a risk factor associated with high motor vehicle crash rates of young drivers. A number of programs have been developed to improve these skills. The purpose of this review was to assess the empirical literature on hazard anticipation training for young drivers. Methods Studies were included if they: 1) included an assessment of hazard anticipation training outcomes; 2) were published between January 1, 1980 and December 31, 2013 in an English language peer-reviewed journal or conference proceeding; and 3) included at least one group that uniquely comprised a cohort of participants <21 years. Nineteen studies met inclusion criteria. Results Studies used a variety of training methods including interactive computer programs, videos, simulation, commentary driving, or a combination of approaches. Training effects were predominantly measured through computer-based testing and driving simulation with eye tracking. Four studies included an on-road evaluation. Most studies evaluated short-term outcomes (immediate or few days). In all studies, young drivers showed improvement in selected hazard anticipation outcomes, but none investigated crash effects. Conclusions Although there is promise in existing programs, future research should include long-term follow up, evaluate crash outcomes, and assess the optimal timing of hazard anticipation training taking into account the age and experience level of young drivers. PMID:26112734

  16. Crossing Hazard Functions in Common Survival Models

    PubMed Central

    Zhang, Jiajia; Peng, Yingwei

    2010-01-01

    Crossing hazard functions have extensive applications in modeling survival data. However, existing studies in the literature mainly focus on comparing crossed hazard functions and estimating the time at which the hazard functions cross, and there is little theoretical work on conditions under which hazard functions from a model will have a crossing. In this paper, we investigate crossing status of hazard functions from the proportional hazards (PH) model, the accelerated hazard (AH) model, and the accelerated failure time (AFT) model. We provide and prove conditions under which the hazard functions from the AH and the AFT models have no crossings or a single crossing. A few examples are also provided to demonstrate how the conditions can be used to determine crossing status of hazard functions from the three models. PMID:20613974

  17. INTERNAL HAZARDS ANALYSIS FOR LICENSE APPLICATION

    SciTech Connect

    R.J. Garrett

    2005-02-17

    The purpose of this internal hazards analysis is to identify and document the internal hazards and potential initiating events associated with preclosure operations of the repository at Yucca Mountain. Internal hazards are those hazards presented by the operation of the facility and by its associated processes that can potentially lead to a radioactive release or cause a radiological hazard. In contrast to external hazards, internal hazards do not involve natural phenomena and external man-made hazards. This internal hazards analysis was performed in support of the preclosure safety analysis and the License Application for the Yucca Mountain Project. The methodology for this analysis provides a systematic means to identify internal hazards and potential initiating events that may result in a radiological hazard or radiological release during the repository preclosure period. These hazards are documented in tables of potential internal hazards and potential initiating events (Section 6.6) for input to the repository event sequence categorization process. The results of this analysis will undergo further screening and analysis based on the criteria that apply to the performance of event sequence analyses for the repository preclosure period. The evolving design of the repository will be re-evaluated periodically to ensure that internal hazards that have not been previously evaluated are identified.

  18. A registry study of the association of patient's residence and age with colorectal cancer survival.

    PubMed

    Sankaranarayanan, Jayashri; Qiu, Fang; Watanabe-Galloway, Shinobu

    2014-04-01

    Because of limited literature from rural states of the United States like Nebraska, we evaluated the association of patient's age, Office of Management and Budget residence-county categories (rural-nonmetro, micropolitan-nonmetro, urban), and significant interactions between confounding-variables with colorectal cancer (CRC) survival. This retrospective 1998-2003 study of 6561 CRC patients from the Nebraska Cancer Registry showed median patient survival in colon and rectal cancer in urban, rural and micropolitan counties were 33, 36, and 46 months and 41, 47, 49 months, respectively. In Cox proportional-hazards analyses, after adjusting for significant demographics (age, race, marital status in colon cancer; age, insurance status in rectal cancer), cancer stage, surgery and radiation treatments; 1) no-chemotherapy urban colon cancer patients had significantly shorter survival (rural vs urban; adjusted hazard ratio, HR: 0.78 or urban vs rural HR: 1.28; micropolitan vs urban, HR: 0.78) and 2) no-surgery urban (vs rural, HR: 1.49); micropolitan (vs rural, HR: 2.01) rectal cancer patients had significantly shorter survival. Colon cancer (≥65 years) and rectal cancer (≥75 years) elderly each versus patients aged 19-64 years old had significantly shorter survival (all p < 0.01). The association of patients' age and treatment/residence-county interactions with CRC survival warrant decision-makers' attention.

  19. Mercury as a health hazard.

    PubMed

    Curtis, H A; Ferguson, S D; Kell, R L; Samuel, A H

    1987-03-01

    Pink disease has virtually disappeared since teething powders were withdrawn. We describe a case in a boy who was exposed to metallic mercury vapour. We discuss the potential health hazard of spilled elemental mercury in the house and the difficulties of removing it from the environment.

  20. Electrocution Hazards on the Farm

    MedlinePlus

    ... by overhead power lines, standby generators, and general operating procedures of electrical systems at the farm work site. Electrocution hazards The ... electricity generated by a farm operation’s emergency power system from entering the ... operating precautions, equipment can come in contact with electrical ...

  1. Chemical hazards in the organisation.

    PubMed

    Winder, Chris

    2012-01-01

    The use of hazardous chemicals in organisations represents a substantial risk to occupational health, safety and the environment (OHSE). Organisational directors and managers have a responsibility to provide and maintain organisational management systems that manage these risks. The risk management approach of establishing organisational considerations, identifying chemical hazards (health and environmental), assessing and controlling risks and evaluating management activities has become the de facto means of managing organisational hazards in general and may be satisfactorily applied to the management of chemicals in the organisation. The Globally Harmonized System for the Classification and Labelling of Chemicals (GHS) is now at the forefront of major regulatory issues facing the chemicals manufacturing industry and downstream users of chemicals. The GHS offers one system for the classification of all dangerous, toxic and environmental (ecotoxic) effects of chemicals. Organisations should develop occupational health, safety and environment (OHSE) management systems which contain programs and procedures that contain systems for inventory control, hazard communication, competency training, risk assessment and control, transport and storage, monitoring and health surveillance, chemical emergencies (including accident investigation), waste minimisation and disposal, record keeping and management system review. PMID:22945564

  2. Title III hazardous air pollutants

    SciTech Connect

    Todd, R.

    1995-12-31

    The author presents an overview of the key provisions of Title III of the Clean Air Act Amendments of 1990. The key provisions include the following: 112(b) -- 189 Hazardous Air Pollutants (HAP); 112(a) -- Major Source: 10 TPY/25 TPY; 112(d) -- Application of MACT; 112(g) -- Modifications; 112(I) -- State Program; 112(j) -- The Hammer; and 112(r) -- Accidental Release Provisions.

  3. Modeling lahar behavior and hazards

    USGS Publications Warehouse

    Manville, Vernon; Major, Jon J.; Fagents, Sarah A.

    2013-01-01

    Lahars are highly mobile mixtures of water and sediment of volcanic origin that are capable of traveling tens to > 100 km at speeds exceeding tens of km hr-1. Such flows are among the most serious ground-based hazards at many volcanoes because of their sudden onset, rapid advance rates, long runout distances, high energy, ability to transport large volumes of material, and tendency to flow along existing river channels where populations and infrastructure are commonly concentrated. They can grow in volume and peak discharge through erosion and incorporation of external sediment and/or water, inundate broad areas, and leave deposits many meters thick. Furthermore, lahars can recur for many years to decades after an initial volcanic eruption, as fresh pyroclastic material is eroded and redeposited during rainfall events, resulting in a spatially and temporally evolving hazard. Improving understanding of the behavior of these complex, gravitationally driven, multi-phase flows is key to mitigating the threat to communities at lahar-prone volcanoes. However, their complexity and evolving nature pose significant challenges to developing the models of flow behavior required for delineating their hazards and hazard zones.

  4. Poor People as Environmental Hazards.

    ERIC Educational Resources Information Center

    Douw, John

    1979-01-01

    In the United States Court of Appeals decision which ruled against New York City's plan to build 160 units of public housing in its West Side Urban Renewal Area, low income people were viewed as a threat to the environment in the same way as more familiar kinds of hazards protected against by federal environmental law. (Author/EB)

  5. Proportional Hazards Models of Graduation

    ERIC Educational Resources Information Center

    Chimka, Justin R.; Reed-Rhoads, Teri; Barker, Kash

    2008-01-01

    Survival analysis is a statistical tool used to describe the duration between events. Many processes in medical research, engineering, and economics can be described using survival analysis techniques. This research involves studying engineering college student graduation using Cox proportional hazards models. Among male students with American…

  6. Medical waste: a minimal hazard.

    PubMed

    Keene, J H

    1991-11-01

    Medical waste is a subset of municipal waste, and regulated medical waste comprises less than 1% of the total municipal waste volume in the United States. As part of the overall waste stream, medical waste does contribute in a relative way to the aesthetic damage of the environment. Likewise, some small portion of the total release of hazardous chemicals and radioactive materials is derived from medical wastes. These comments can be made about any generated waste, regulated or unregulated. Healthcare professionals, including infection control personnel, microbiologists, public health officials, and others, have unsuccessfully argued that there is no evidence that past methods of treatment and disposal of regulated medical waste constitute any public health hazard. Historically, discovery of environmental contamination by toxic chemical disposal has followed assurances that the material was being disposed of in a safe manner. Therefore, a cynical public and its elected officials have demanded proof that the treatment and disposal of medical waste (i.e., infectious waste) do not constitute a public health hazard. Existent studies on municipal waste provide that proof. In order to argue that the results of these municipal waste studies are demonstrative of the minimal potential infectious environmental impact and lack of public health hazard associated with medical waste, we must accept the following: that the pathogens are the same whether they come from the hospital or the community, and that the municipal waste studied contained waste materials we now define as regulated medical waste.(ABSTRACT TRUNCATED AT 250 WORDS)

  7. 77 FR 17573 - Hazard Communication

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-26

    ... 1983 and covered the manufacturing sector of industry (48 FR 53280, Nov. 25, 1983). (Please note: The... where employees are potentially exposed to hazardous chemicals (52 FR 31852, Aug. 24, 1987). Although... actions, the rule has been fully enforced in all industries regulated by OSHA since March 17, 1989 (54...

  8. Tephra transport, sedimentation and hazards

    NASA Astrophysics Data System (ADS)

    Volentik, Alain C. M.

    Tephra deposits are one of the possible outcomes of explosive volcanic eruptions and are the result of vertical settling of volcanic particles that have been expelled from the volcanic vent into the atmosphere, following magma fragmentation within the volcanic conduit. Tephra fallout represents the main volcanic hazard to populated areas and critical facilities. Therefore, it is crucial to better understand processes that lead to tephra transport, sedimentation and hazards. In this study, and based on detailed mapping and sampling of the tephra deposit of the 2450BP Plinian eruption of Pululagua volcano (Ecuador), I investigate tephra deposits through a variety of approaches, including empirical and analytical modeling of tephra thickness and grain size data to infer important eruption source parameters (e.g. column height, total mass ejected, total grain size distribution of the deposit). I also use a statistical approach (smoothed bootstrap with replacement method) to assess the uncertainty in the eruptive parameters. The 2450BP Pululagua volcanic plume dynamics were also explored through detailed grain size analysis and 1D modeling of tephra accumulation. Finally, I investigate the influence of particle shape on tephra accumulation on the ground through a quantitative and comprehensive study of the shape of volcanic ash. As the global need for energy is expected to grow in the future, many future natural hazard studies will likely involve the assessment of volcanic hazards at critical facilities, including nuclear power plants. I address the potential hazards from tephra fallout, pyroclastic flows and lahars for the Bataan Nuclear Power Plant (Philippines) posed by three nearby volcanoes capable of impacting the site during an explosive eruption. I stress the need for good constraints (stratigraphic analysis and events dating) on past eruptive events to better quantify the probability of future events at potentially active volcanoes, the need for probabilistic

  9. Is complexity of work associated with risk of dementia? The Canadian Study of Health And Aging.

    PubMed

    Kröger, Edeltraut; Andel, Ross; Lindsay, Joan; Benounissa, Zohra; Verreault, René; Laurin, Danielle

    2008-04-01

    The authors evaluated the association of complexity of work with data, people, and things with the incidence of dementia, Alzheimer's disease, and vascular dementia in the Canadian Study of Health and Aging, while adjusting for work-related physical activity. The Canadian Study of Health and Aging is a 10-year population study, from 1991 to 2001, of a representative sample of persons aged 65 years or older. Lifetime job history allowed application of complexity scores and classification of work-related physical activity. Analyses included 3,557 subjects, of whom 400 were incident dementia cases, including 299 with Alzheimer's disease and 93 with vascular dementia. In fully adjusted Cox regression models, high complexity of work with people or things reduced risk of dementia (hazard ratios were 0.66 (95% confidence interval: 0.44, 0.98) and 0.72 (95% confidence interval: 0.52, 0.99), respectively) but not Alzheimer's disease. For vascular dementia, hazard ratios were 0.36 (95% confidence interval: 0.15, 0.90) for high complexity of work with people and 0.50 (95% confidence interval: 0.25, 1.00) for high complexity of work with things. Subgroup analyses according to median duration (23 years) of principal occupation showed that associations with complexity varied according to duration of employment. High complexity of work appears to be associated with risk of dementia, but effects may vary according to subtype. PMID:18263600

  10. Portable sensor for hazardous waste

    SciTech Connect

    Piper, L.G.; Hunter, A.J.R.; Fraser, M.E.; Davis, S.J.

    1996-12-31

    We are part-way through the second phase of a 4-year program designed to develop a portable monitor for sensitive hazardous waste detection. The ultimate goal of the program is to develop our concept to the prototype instrument level. Our monitor will be a compact, portable instrument that will allow real-time, in situ, monitoring of hazardous wastes. This instrument will be able to provide the means for rapid field screening of hazardous waste sites to map the areas of greatest contamination. Remediation efforts can then focus on these areas. Our analysis approach is to excite atomic and molecular fluorescence by the technique of active nitrogen energy transfer (ANET). The active nitrogen is made in a dielectric-barrier (D-B) discharge in nitrogen at atmospheric pressure. Only a few emission lines or bands are excited for each hazardous species, so spectral resolution requirements are greatly simplified over those of other spectroscopic techniques. The D-B discharge is compact, 1 to 2 cm in diameter and 1 to 10 cm long. Furthermore, the discharge power requirements are quite modest, so that the unit can be powered by batteries. Thus an instrument based on ANET can readily be made portable. Our results indicate that ANET is a very sensitive technique for monitoring heavy metals and chlorinated hydrocarbons. We have demonstrated an overall detection sensitivity for most species that is at or below ppb levels. ANET alone, however, appears to be most successful in treating hazardous species that have been atomized. We are therefore developing a hybrid technique which combines a miniature, solid-state laser for sample collection and vaporization with ANET for subsequent detection. This approach requires no special sample preparation, can operate continuously, and lends itself well to compact packaging.

  11. Preoperative platelet to lymphocyte ratio is a valuable prognostic biomarker in patients with colorectal cancer

    PubMed Central

    You, Jie; Zhu, Gui-Qi; Xie, Linka; Liu, Wen-Yue; Shi, Liang; Wang, Ou-Chen; Huang, Zong-Hai; Braddock, Martin; Guo, Gui-Long; Zheng, Ming-Hua

    2016-01-01

    Objectives Recent studies suggest that an elevated preoperative platelet to lymphocyte ratio (PLR) may be considered a poor prognostic biomarker in patients with colorectal cancer (CRC). The aim of this study was to evaluate the prognostic impact of PLR in patients with CRC. Methods We enrolled 1314 patients who underwent surgery for CRC between 2005 and 2011. Preoperative PLR level was stratified into quintiles for Kaplan-Meier analysis and multivariable Cox proportional hazard regression models. Results Higher PLR quintiles were significantly associated with poorer overall survival (P = 0.002). Multivariate analysis showed that PLR was an independent risk factor for overall survival (OS) (P = 0.034). Patients in PLR quintile 5 had lower overall survival than in quintile 1 (hazard ratio (HR) = 1.701, 95% confidence interval (CI): 1.267–2.282, P < 0.001). Although patients in PLR quintile 5 had significantly lower disease-free survival (DFS) than in quintile 1 (HR = 1.522, 95% CI: 1.114–2.080, P = 0.008), this association was not significant after multivariable adjustment (P = 0.075). In the subgroup analysis, PLR remained an independent factor in terms of advanced tumor stage (III, IV), male sex, carcinoembryonic antigen (≤ 5 ng/ml), age (> 65 years) and body mass index (≤ 25) (P < 0.05 for all measurements). The results remained unchanged when the PLR was analyzed as a dichotomous variable by applying different cut-off values of 150, 185, 220. Conclusions Elevated preoperative PLR was independently associated with an increased risk of mortality in patients with CRC. The utility of PLR may help to improve prognostic predictors. PMID:27027440

  12. How old are you, really? Communicating chronic risk through 'effective age' of your body and organs.

    PubMed

    Spiegelhalter, David

    2016-01-01

    In communicating chronic risks, there is increasing use of a metaphor that can be termed 'effective-age': the age of a 'healthy' person who has the same risk profile as the individual in question. Popular measures include 'real-age', 'heart-age', 'lung-age' and so on.Here we formally define this concept, and illustrate its use in a variety of areas. We explore conditions under which the years lost or gained that are associated with exposure to risk factors depends neither on current chronological age, nor the period over which the risk is defined. These conditions generally hold for all-cause adult mortality, which enables a simple and vivid translation from hazard-ratios to years lost or gained off chronological age. Finally we consider the attractiveness and impact of this concept.Under reasonable assumptions, the risks associated with specific behaviours can be expressed in terms of years gained or lost off your effective age. The idea of effective age appears a useful and attractive metaphor to vividly communicate risks to individuals. PMID:27496144

  13. How old are you, really? Communicating chronic risk through 'effective age' of your body and organs.

    PubMed

    Spiegelhalter, David

    2016-08-05

    In communicating chronic risks, there is increasing use of a metaphor that can be termed 'effective-age': the age of a 'healthy' person who has the same risk profile as the individual in question. Popular measures include 'real-age', 'heart-age', 'lung-age' and so on.Here we formally define this concept, and illustrate its use in a variety of areas. We explore conditions under which the years lost or gained that are associated with exposure to risk factors depends neither on current chronological age, nor the period over which the risk is defined. These conditions generally hold for all-cause adult mortality, which enables a simple and vivid translation from hazard-ratios to years lost or gained off chronological age. Finally we consider the attractiveness and impact of this concept.Under reasonable assumptions, the risks associated with specific behaviours can be expressed in terms of years gained or lost off your effective age. The idea of effective age appears a useful and attractive metaphor to vividly communicate risks to individuals.

  14. Income replacement ratios in the Health and Retirement Study.

    PubMed

    Purcell, Patrick J

    2012-01-01

    This article describes the income replacement ratio as a measure of retirement income adequacy and identifies several issues analysts must consider when calculating a replacement ratio. The article presents the income replacement ratios experienced by participants in the original sample cohort of the Health and Retirement Study (HRS), who were born between 1931 and 1941. Replacement ratios are shown by the respondent's birth cohort, age when first classified as retired in the HRS, and preretirement income quartile. Median replacement ratios fall as the retirement period grows longer.

  15. Updated Colombian Seismic Hazard Map

    NASA Astrophysics Data System (ADS)

    Eraso, J.; Arcila, M.; Romero, J.; Dimate, C.; Bermúdez, M. L.; Alvarado, C.

    2013-05-01

    The Colombian seismic hazard map used by the National Building Code (NSR-98) in effect until 2009 was developed in 1996. Since then, the National Seismological Network of Colombia has improved in both coverage and technology providing fifteen years of additional seismic records. These improvements have allowed a better understanding of the regional geology and tectonics which in addition to the seismic activity in Colombia with destructive effects has motivated the interest and the need to develop a new seismic hazard assessment in this country. Taking advantage of new instrumental information sources such as new broad band stations of the National Seismological Network, new historical seismicity data, standardized global databases availability, and in general, of advances in models and techniques, a new Colombian seismic hazard map was developed. A PSHA model was applied. The use of the PSHA model is because it incorporates the effects of all seismic sources that may affect a particular site solving the uncertainties caused by the parameters and assumptions defined in this kind of studies. First, the seismic sources geometry and a complete and homogeneous seismic catalog were defined; the parameters of seismic rate of each one of the seismic sources occurrence were calculated establishing a national seismotectonic model. Several of attenuation-distance relationships were selected depending on the type of seismicity considered. The seismic hazard was estimated using the CRISIS2007 software created by the Engineering Institute of the Universidad Nacional Autónoma de México -UNAM (National Autonomous University of Mexico). A uniformly spaced grid each 0.1° was used to calculate the peak ground acceleration (PGA) and response spectral values at 0.1, 0.2, 0.3, 0.5, 0.75, 1, 1.5, 2, 2.5 and 3.0 seconds with return periods of 75, 225, 475, 975 and 2475 years. For each site, a uniform hazard spectrum and exceedance rate curves were calculated. With the results, it is

  16. The hazards of the changing hazard of dialysis modalities.

    PubMed

    Argyropoulos, Christos P; Unruh, Mark L

    2014-11-01

    The impact of the dialysis modality on patient survival has received considerable epidemiological attention, with most studies suggesting an early benefit favoring peritoneal dialysis over hemodialysis. Kumar et al. report the relative outcomes of the two modalities in incident patients followed by an accountable care organization. Using advanced statistical techniques for non-proportional hazards survival models, the authors corroborate the early benefit of peritoneal dialysis for the first 3 years and equivalent outcomes thereafter.

  17. Seismic hazard assessment: Issues and alternatives

    USGS Publications Warehouse

    Wang, Z.

    2011-01-01

    Seismic hazard and risk are two very important concepts in engineering design and other policy considerations. Although seismic hazard and risk have often been used inter-changeably, they are fundamentally different. Furthermore, seismic risk is more important in engineering design and other policy considerations. Seismic hazard assessment is an effort by earth scientists to quantify seismic hazard and its associated uncertainty in time and space and to provide seismic hazard estimates for seismic risk assessment and other applications. Although seismic hazard assessment is more a scientific issue, it deserves special attention because of its significant implication to society. Two approaches, probabilistic seismic hazard analysis (PSHA) and deterministic seismic hazard analysis (DSHA), are commonly used for seismic hazard assessment. Although PSHA has been pro-claimed as the best approach for seismic hazard assessment, it is scientifically flawed (i.e., the physics and mathematics that PSHA is based on are not valid). Use of PSHA could lead to either unsafe or overly conservative engineering design or public policy, each of which has dire consequences to society. On the other hand, DSHA is a viable approach for seismic hazard assessment even though it has been labeled as unreliable. The biggest drawback of DSHA is that the temporal characteristics (i.e., earthquake frequency of occurrence and the associated uncertainty) are often neglected. An alternative, seismic hazard analysis (SHA), utilizes earthquake science and statistics directly and provides a seismic hazard estimate that can be readily used for seismic risk assessment and other applications. ?? 2010 Springer Basel AG.

  18. Healthy Aging

    MedlinePlus

    ... About Us Contact Us Text size | Print | Healthy Aging This information in Spanish ( en español ) A healthy ... Aging email updates. Enter email address Submit Healthy Aging news Accessibility | Privacy policy | Disclaimers | FOIA | Link to ...

  19. Healthy Aging

    MedlinePlus

    ... A Change Contrast print sign up Share Healthy Aging This category offers tips on how to stay ... with Smell Problems with Taste Skin Care and Aging Sleep and Aging Taking Medicines Talking with Your ...

  20. Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk

    PubMed Central

    Brand, Judith S.; van der Schouw, Yvonne T.; Onland-Moret, N. Charlotte; Sharp, Stephen J.; Ong, Ken K.; Khaw, Kay-Tee; Ardanaz, Eva; Amiano, Pilar; Boeing, Heiner; Chirlaque, Maria-Dolores; Clavel-Chapelon, Françoise; Crowe, Francesca L.; de Lauzon-Guillain, Blandine; Duell, Eric J.; Fagherazzi, Guy; Franks, Paul W.; Grioni, Sara; Groop, Leif C.; Kaaks, Rudolf; Key, Timothy J.; Nilsson, Peter M.; Overvad, Kim; Palli, Domenico; Panico, Salvatore; Quirós, J. Ramón; Rolandsson, Olov; Sacerdote, Carlotta; Sánchez, María-José; Slimani, Nadia; Teucher, Birgit; Tjonneland, Anne; Tumino, Rosario; van der A, Daphne L.; Feskens, Edith J.M.; Langenberg, Claudia; Forouhi, Nita G.; Riboli, Elio; Wareham, Nicholas J.

    2013-01-01

    OBJECTIVE Age at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk. RESEARCH DESIGN AND METHODS Data were obtained from the InterAct study, a prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition. A total of 3,691 postmenopausal type 2 diabetic case subjects and 4,408 subcohort members were included in the analysis, with a median follow-up of 11 years. Prentice weighted Cox proportional hazards models were adjusted for age, known risk factors for diabetes, and reproductive factors, and effect modification by BMI, waist circumference, and smoking was studied. RESULTS Mean (SD) age of the subcohort was 59.2 (5.8) years. After multivariable adjustment, hazard ratios (HRs) of type 2 diabetes were 1.32 (95% CI 1.04–1.69), 1.09 (0.90–1.31), 0.97 (0.86–1.10), and 0.85 (0.70–1.03) for women with menopause at ages <40, 40–44, 45–49, and ≥55 years, respectively, relative to those with menopause at age 50–54 years. The HR per SD younger age at menopause was 1.08 (1.02–1.14). Similarly, a shorter reproductive life span was associated with a higher diabetes risk (HR per SD lower reproductive life span 1.06 [1.01–1.12]). No effect modification by BMI, waist circumference, or smoking was observed (P interaction all > 0.05). CONCLUSIONS Early menopause is associated with a greater risk of type 2 diabetes. PMID:23230098

  1. Assessment of volcanic hazards, vulnerability, risk and uncertainty (Invited)

    NASA Astrophysics Data System (ADS)

    Sparks, R. S.

    2009-12-01

    A volcanic hazard is any phenomenon that threatens communities . These hazards include volcanic events like pyroclastic flows, explosions, ash fall and lavas, and secondary effects such as lahars and landslides. Volcanic hazards are described by the physical characteristics of the phenomena, by the assessment of the areas that they are likely to affect and by the magnitude-dependent return period of events. Volcanic hazard maps are generated by mapping past volcanic events and by modelling the hazardous processes. Both these methods have their strengths and limitations and a robust map should use both approaches in combination. Past records, studied through stratigraphy, the distribution of deposits and age dating, are typically incomplete and may be biased. Very significant volcanic hazards, such as surge clouds and volcanic blasts, are not well-preserved in the geological record for example. Models of volcanic processes are very useful to help identify hazardous areas that do not have any geological evidence. They are, however, limited by simplifications and incomplete understanding of the physics. Many practical volcanic hazards mapping tools are also very empirical. Hazards maps are typically abstracted into hazards zones maps, which are some times called threat or risk maps. Their aim is to identify areas at high levels of threat and the boundaries between zones may take account of other factors such as roads, escape routes during evacuation, infrastructure. These boundaries may change with time due to new knowledge on the hazards or changes in volcanic activity levels. Alternatively they may remain static but implications of the zones may change as volcanic activity changes. Zone maps are used for planning purposes and for management of volcanic crises. Volcanic hazards maps are depictions of the likelihood of future volcanic phenomena affecting places and people. Volcanic phenomena are naturally variable, often complex and not fully understood. There are

  2. Flood hazard, vulnerability, and risk assessment for human life

    NASA Astrophysics Data System (ADS)

    Pan, T.; Chang, T.; Lai, J.; Hsieh, M.; Tan, Y.; Lin, Y.

    2011-12-01

    Flood risk assessment is an important issue for the countries suffering tropical cyclones and monsoon. Taiwan is located in the hot zone of typhoon tracks in the Western Pacific. There are three to five typhoons landing Taiwan every year. Typhoons and heavy rainfalls often cause inundation disaster rising with the increase of population and the development of social economy. The purpose of this study is to carry out the flood hazard, vulnerability and risk in term of human life. Based on the concept that flood risk is composed by flood hazard and vulnerability, a inundation simulation is performed to evaluate the factors of flood hazard for human life according to base flood (100-year return period). The flood depth, velocity and rising ratio are the three factors of flood hazards. Furthermore, the factors of flood vulnerability are identified in terms of human life that are classified into two main factors, residents and environment. The sub factors related to residents are the density of population and the density of vulnerable people including elders, youngers and disabled persons. The sub factors related to environment include the the number of building floors, the locations of buildings, the and distance to rescue center. The analytic hierarchy process (AHP) is adopted to determine the weights of these factors. The risk matrix is applied to show the risk from low to high based on the evaluation of flood hazards and vulnerabilities. The Tseng-Wen River watershed is selected as the case study because a serious flood was induced by Typhoon Morakot in 2009, which produced a record-breaking rainfall of 2.361mm in 48 hours in the last 50 years. The results of assessing the flood hazard, vulnerability and risk in term of human life could improve the emergency operation for flood disaster to prepare enough relief goods and materials during typhoon landing.

  3. Ratios of internal conversion coefficients

    SciTech Connect

    Raman, S.; Ertugrul, M.; Nestor, C.W. . E-mail: CNestorjr@aol.com; Trzhaskovskaya, M.B.

    2006-03-15

    We present here a database of available experimental ratios of internal conversion coefficients for different atomic subshells measured with an accuracy of 10% or better for a number of elements in the range 26 {<=} Z {<=} 100. The experimental set involves 414 ratios for pure and 1096 ratios for mixed-multipolarity nuclear transitions in the transition energy range from 2 to 2300 keV. We give relevant theoretical ratios calculated in the framework of the Dirac-Fock method with and without regard for the hole in the atomic subshell after conversion. For comparison, the ratios obtained within the relativistic Hartree-Fock-Slater approximation are also presented. In cases where several ratios were measured for the same transition in a given isotope in which two multipolarities were involved, we present the mixing ratio {delta} {sup 2} obtained by a least squares fit.

  4. 78 FR 5822 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-28

    ... SECURITY Federal Emergency Management Agency Proposed Flood Hazard Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: Comments are requested on proposed flood hazard determinations, which may include additions or modifications of any Base Flood Elevation (BFE), base flood...

  5. 77 FR 18846 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ... SECURITY Federal Emergency Management Agency Proposed Flood Hazard Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: Comments are requested on proposed flood hazard determinations, which may include additions or modifications of any Base Flood Elevation (BFE), base flood...

  6. 77 FR 18844 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ... SECURITY Federal Emergency Management Agency Proposed Flood Hazard Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: Comments are requested on proposed flood hazard determinations, which may include additions or modifications of any Base Flood Elevation (BFE), base flood...

  7. 77 FR 18841 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ... SECURITY Federal Emergency Management Agency Proposed Flood Hazard Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: Comments are requested on proposed flood hazard determinations, which may include additions or modifications of any Base Flood Elevation (BFE), base flood...

  8. 78 FR 5826 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-28

    ... SECURITY Federal Emergency Management Agency Proposed Flood Hazard Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: Comments are requested on proposed flood hazard determinations, which may include additions or modifications of any Base Flood Elevation (BFE), base flood...

  9. 78 FR 5824 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-28

    ... SECURITY Federal Emergency Management Agency Proposed Flood Hazard Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: Comments are requested on proposed flood hazard determinations, which may include additions or modifications of any Base Flood Elevation (BFE), base flood...

  10. 78 FR 49278 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-13

    ... SECURITY Federal Emergency Management Agency Proposed Flood Hazard Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: Comments are requested on proposed flood hazard determinations, which may include additions or modifications of any Base Flood Elevation (BFE), base flood...

  11. 78 FR 21143 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-09

    ... SECURITY Federal Emergency Management Agency Proposed Flood Hazard Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: Comments are requested on proposed flood hazard determinations, which may include additions or modifications of any Base Flood Elevation (BFE), base flood...

  12. 77 FR 18839 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ... SECURITY Federal Emergency Management Agency Proposed Flood Hazard Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: Comments are requested on proposed flood hazard determinations, which may include additions or modifications of any Base Flood Elevation (BFE), base flood...

  13. 77 FR 18842 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ... SECURITY Federal Emergency Management Agency Proposed Flood Hazard Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: Comments are requested on proposed flood hazard determinations, which may include additions or modifications of any Base Flood Elevation (BFE), base flood...

  14. 77 FR 18835 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ... SECURITY Federal Emergency Management Agency Proposed Flood Hazard Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: Comments are requested on proposed flood hazard determinations, which may include additions or modifications of any Base Flood Elevation (BFE), base flood...

  15. 78 FR 49277 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-13

    ... SECURITY Federal Emergency Management Agency Proposed Flood Hazard Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: Comments are requested on proposed flood hazard determinations, which may include additions or modifications of any Base Flood Elevation (BFE), base flood...

  16. 77 FR 18837 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ... SECURITY Federal Emergency Management Agency Proposed Flood Hazard Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: Comments are requested on proposed flood hazard determinations, which may include additions or modifications of any Base Flood Elevation (BFE), base flood...

  17. Safety VI: Hazards in Physics Laboratories.

    ERIC Educational Resources Information Center

    Orton, R. J. J.

    1985-01-01

    Summarizes advice from the Laboratory Safeguards Subcommittee of the Association for Science Education related to flames and heat, hazardous chemicals, electricity and dangerous voltages, and mechanical hazards. Knowledge is cited as the key to preventing accidents in physics laboratories. (DH)

  18. Models of volcanic eruption hazards

    SciTech Connect

    Wohletz, K.H.

    1992-01-01

    Volcanic eruptions pose an ever present but poorly constrained hazard to life and property for geothermal installations in volcanic areas. Because eruptions occur sporadically and may limit field access, quantitative and systematic field studies of eruptions are difficult to complete. Circumventing this difficulty, laboratory models and numerical simulations are pivotal in building our understanding of eruptions. For example, the results of fuel-coolant interaction experiments show that magma-water interaction controls many eruption styles. Applying these results, increasing numbers of field studies now document and interpret the role of external water eruptions. Similarly, numerical simulations solve the fundamental physics of high-speed fluid flow and give quantitative predictions that elucidate the complexities of pyroclastic flows and surges. A primary goal of these models is to guide geologists in searching for critical field relationships and making their interpretations. Coupled with field work, modeling is beginning to allow more quantitative and predictive volcanic hazard assessments.

  19. Landslide Hazards - A National Threat

    USGS Publications Warehouse

    ,

    2005-01-01

    Landslides occur and can cause damage in all 50 States. Severe storms, earthquakes, volcanic activity, coastal wave attack, and wildfires can cause widespread slope instability. Landslide danger may be high even as emergency personnel are providing rescue and recovery services. To address landslide hazards, several questions must be considered: Where and when will landslides occur? How big will the landslides be? How fast and how far will they move? What areas will the landslides affect or damage? How frequently do landslides occur in a given area? Answers to these questions are needed to make accurate landslide hazard maps and forecasts of landslide occurrence, and to provide information on how to avoid or mitigate landslide impacts. The U.S. Geological Survey develops methods to answer these questions to help protect U.S. communities from the dangers of landslides.

  20. Magnetohydrodynamics and its hazard assessment

    NASA Astrophysics Data System (ADS)

    Chan, W.-T.

    1981-11-01

    Potential occupational and environmental hazards of a typical combined open-cycle MHD/steam cycle power plant are critically assessed on the basis of direct/indirect research information. Among the potential occupational hazards, explosion at the coal feed system or at the superconducting magnet; combustor rupture in a confined pit; high intensity dc magnetic field exposure at the channel; and combustion products leakage from the pressurized systems are of primary concern. While environmental emissions of SO(x), NO(x) and fine particulates are considered under control in experimental scale, control effectiveness at high capacity operation remains uncertain. Gaseous emission of some highly toxic trace elements including radioactive species may be of concern without gas cleaning device in the MHD design.

  1. Hazardous occupations in Great Britain.

    PubMed

    Roberts, Stephen E

    2002-08-17

    The aim of this study was to investigate the most hazardous of all occupations in Great Britain. The causes of all deaths in British merchant seafaring and trawler fishing, traditionally the two most dangerous occupations, were established for the period between 1976 and 1995 and compared with official mortality statistics for other occupations. Fishermen were 52.4 times more likely to have a fatal accident at work (95% CI 42.9-63.8), and seafarers were 26.2 times more likely (19.8-34.7), compared with other British workers. Although the number of work-related deaths has decreased in recent decades, in relative terms the occupations of fishing and seafaring remain as hazardous as before. If mortality rates in these occupations are to decrease, unsafe working practices, especially unnecessary operations in treacherous conditions, should be reduced. PMID:12241660

  2. Earthquake hazards: a national threat

    USGS Publications Warehouse

    ,

    2006-01-01

    Earthquakes are one of the most costly natural hazards faced by the Nation, posing a significant risk to 75 million Americans in 39 States. The risks that earthquakes pose to society, including death, injury, and economic loss, can be greatly reduced by (1) better planning, construction, and mitigation practices before earthquakes happen, and (2) providing critical and timely information to improve response after they occur. As part of the multi-agency National Earthquake Hazards Reduction Program, the U.S. Geological Survey (USGS) has the lead Federal responsibility to provide notification of earthquakes in order to enhance public safety and to reduce losses through effective forecasts based on the best possible scientific information.

  3. Robots Working with Hazardous Materials

    SciTech Connect

    Amai, W.; Fahrenholtz, J.

    1999-01-06

    While many research and development activities take place at Sandia National Laboratories' Intelligent Systems and Robotics Center (ISRC), where the "rubber meets the road" is in the ISRC'S delivered systems. The ISRC has delivered several systems over the last few years that handle hazardous materials on a daily basis, and allow human workers to move to a safer, supervisory role than the "hands-on" operations that they used to perform. The ISRC at Sandia performs a large range of research and development activities, including development and delivery of one-of-a-kind robotic systems for use with hazardous materials. Our mission is to create systems for operations where people can't or don't want to perform the operations by hand, and the systems described in this article are several of our first-of-a-kind deliveries to achieve that mission.

  4. [Occupational hazards and bladder cancer].

    PubMed

    Nizamova, R S

    1991-01-01

    Occupational exposure to health hazards was studied in 258 industrial workers who had developed cancer of the bladder against 454 matched controls. All the test subjects and controls were residents of the Tambov Province centers of chemical industry. Statistical significance (relative risk-4.7) was established for exposure to aromatic amines. For those contacting with aniline dyes the relative risk (RR) made up 2.4. The risk to develop bladder cancer in powder shops (RR-3.2) was attributed to the hazards of dyes and diphenylamine. In leather-shoe and textile industry the exposure to dyes was not safe (RR-6.1), neither was it to chemicals, oil products, pesticides, overheating (RR-3.2, 1.6, 3.2 and 2.9, respectively). It is stated that in line with a significant risk to develop bladder cancer at exposure to aromatic amines there exist a number of occupational factors contributing to this risk.

  5. Hazardous solid waste from agriculture.

    PubMed Central

    Loehr, R C

    1978-01-01

    Large quantities of food processing, crop, forestry, and animal solid wastes are generated in the United States each year. The major components of these wastes are biodegradable. However, they also contain components such as nitrogen, human and animal pathogens, medicinals, feed additives, salts, and certain metals, that under uncontrolled conditions can be detrimental to aquatic, plant, animal, or human life. The most common method of disposal of these wastes is application to the land. Thus the major pathways for transmission of hazards are from and through the soil. Use of these wastes as animal feed also can be a pathway. While at this time there are no crises associated with hazardous materials in agricultural solid wastes, the potential for problems should not be underestimated. Manpower and financial support should be provided to obtain more detailed information in this area, esepcially to better delineate transport and dispersal and to determine and evaluate risks. PMID:367770

  6. Attitudes toward environmental hazards: where do toxic wastes fit?

    PubMed

    Burger, J; Martin, M; Cooper, K; Gochfeld, M

    1997-06-01

    The public is continually faced with making decisions about the risks associated with environmental hazards, and, along with managers and government officials, must make informed decisions concerning possible regulation, mitigation, and restoration of degraded sites or other environmental threats. We explored the attitudes regarding several environmental hazards of six groups of people: undergraduate science majors, undergraduate nonscience majors, and graduate students in environmental health, in ecological risk assessment, and in nonscience disciplines, as well as nonstudents over 35 yr of age. We had predicted that there would be significant differences in attitudes between science and nonscience majors and as a function of age. Relative concerns could be divided into three discrete classes (in descending order of concern): (1) general ecological problems (cutting tropical forests, polluting groundwater, trash along the coasts, lead in drinking water, and acid rain), (2) radon and nuclear wastes, and finally (3) specific nuclear waste facilities, chromium, fertilizers and pesticides, and electromagnetic waves. For any hazard, attitudes were consistent across groups with regard to ranking the severity of the environmental problem and willingness to expend funds to solve the problems. Attitudes about spending money to develop methods to evaluate risk fell in the middle level of concern. There were no major differences among classes of college-age students, or between them and older nonstudents.

  7. Occupational health hazards in mining: an overview.

    PubMed

    Donoghue, A M

    2004-08-01

    This review article outlines the physical, chemical, biological, ergonomic and psychosocial occupational health hazards of mining and associated metallurgical processes. Mining remains an important industrial sector in many parts of the world and although substantial progress has been made in the control of occupational health hazards, there remains room for further risk reduction. This applies particularly to traumatic injury hazards, ergonomic hazards and noise. Vigilance is also required to ensure exposures to coal dust and crystalline silica remain effectively controlled.

  8. Occupational health hazards in mining: an overview.

    PubMed

    Donoghue, A M

    2004-08-01

    This review article outlines the physical, chemical, biological, ergonomic and psychosocial occupational health hazards of mining and associated metallurgical processes. Mining remains an important industrial sector in many parts of the world and although substantial progress has been made in the control of occupational health hazards, there remains room for further risk reduction. This applies particularly to traumatic injury hazards, ergonomic hazards and noise. Vigilance is also required to ensure exposures to coal dust and crystalline silica remain effectively controlled. PMID:15289583

  9. Computer Model Locates Environmental Hazards

    NASA Technical Reports Server (NTRS)

    2008-01-01

    Catherine Huybrechts Burton founded San Francisco-based Endpoint Environmental (2E) LLC in 2005 while she was a student intern and project manager at Ames Research Center with NASA's DEVELOP program. The 2E team created the Tire Identification from Reflectance model, which algorithmically processes satellite images using turnkey technology to retain only the darkest parts of an image. This model allows 2E to locate piles of rubber tires, which often are stockpiled illegally and cause hazardous environmental conditions and fires.

  10. Submarine landslides hazard offshore Israel

    NASA Astrophysics Data System (ADS)

    Katz, Oded

    2016-04-01

    Submarine landslides pose significant natural hazards. They can damage seafloor infrastructure, such as that used to recover oil and gas or seafloor telecommunication cables, and even generate tsunamis. We recently mapped 447 submarine landslides across the east Mediterranean continental slope, offshore Israel (hereafter the studied area). The mapped landslides are found at water depths of 130 m to 1,000 m and their volume ranges 10-5 - 100 km3. Landslide scars are typically related to a critical slope angle of >4° . Landslides at the northern part of the studied area are spatially associated with fault scarps and are smaller than the ones on the southern part. In this work we evaluate the potential hazard to population and to on- and off- shore facilities posed by submarine landslides across the studied area. We integrate three independent probabilities: (1) the probability for a landslide event of a given volume, based on the size distribution of the mapped landslides; (2) the probability for a landslide event in a given time, based on the reoccurrence time of triggering earthquakes with M >7, and on a 50,000 years general time frame derived from submarine landslides identified across the Mediterranean Sea; (3) the probability for a landslide event in a given area, based on the distribution of slopes exceeding the critical angle. Overall, the fraction of potentially destructive landslides (size > 0.1 km3) is small, 0.05. Thus, considering typical planning time scales of less than 100 years, the calculated hazard is only moderate. The small fraction of landslides with tsunamogenic potential (size > 1 km3), suggests that the hazard for landslide-induced tsunamis along the open slope part of the studied area is small. Landslides in the southern part of the studied area are larger and thus present a somewhat bigger potential source of tsunami waves.

  11. Volcanic hazards and aviation safety

    USGS Publications Warehouse

    Casadevall, Thomas J.; Thompson, Theodore B.; Ewert, John W.; ,

    1996-01-01

    An aeronautical chart was developed to determine the relative proximity of volcanoes or ash clouds to the airports and flight corridors that may be affected by volcanic debris. The map aims to inform and increase awareness about the close spatial relationship between volcanoes and aviation operations. It shows the locations of the active volcanoes together with selected aeronautical navigation aids and great-circle routes. The map mitigates the threat that volcanic hazards pose to aircraft and improves aviation safety.

  12. Magnetic storms and induction hazards

    USGS Publications Warehouse

    Love, Jeffrey J.; Rigler, E. Joshua; Pulkkinen, Antti; Balch, Christopher

    2014-01-01

    Magnetic storms are potentially hazardous to the activities and technological infrastructure of modern civilization. This reality was dramatically demonstrated during the great magnetic storm of March 1989, when surface geoelectric fields, produced by the interaction of the time-varying geomagnetic field with the Earth's electrically conducting interior, coupled onto the overlying Hydro-Québec electric power grid in Canada. Protective relays were tripped, the grid collapsed, and about 9 million people were temporarily left without electricity [Bolduc, 2002].

  13. Detection device for hazardous materials

    DOEpatents

    Partin, Judy K.; Grey, Alan E.

    1994-04-05

    A detection device that is activated by the interaction of a hazardous chcal with a coating interactive with said chemical on an optical fiber thereby reducing the amount of light passing through the fiber to a light detector. A combination of optical filters separates the light into a signal beam and a reference beam which after detection, appropriate amplification, and comparison with preset internal signals, activates an alarm means if a predetermined level of contaminant is observed.

  14. Detection device for hazardous materials

    DOEpatents

    Partin, Judy K.; Grey, Alan E.

    1994-01-01

    A detection device that is activated by the interaction of a hazardous chcal with a coating interactive with said chemical on an optical fiber thereby reducing the amount of light passing through the fiber to a light detector. A combination of optical filters separates the light into a signal beam and a reference beam which after detection, appropriate amplification, and comparison with preset internal signals, activates an alarm means if a predetermined level of contaminant is observed.

  15. Age at Antiretroviral Therapy Initiation Predicts Immune Recovery, Death, and Loss to Follow-Up Among HIV-Infected Adults in Urban Zambia

    PubMed Central

    Joseph, Jessica; Mwale, Jonas; Marx, Melissa A.; Goma, Fastone M.; Mulenga, Lloyd B.; Stringer, Jeffrey S.A.; Eron, Joseph J.; Chi, Benjamin H.

    2014-01-01

    Abstract We analyzed the association of age at antiretroviral therapy (ART) initiation with CD4+ T cell count recovery, death, and loss to follow-up (LTFU) among HIV-infected adults in Zambia. We compared baseline characteristics of patients by sex and age at ART initiation [categorized as 16–29 years, 30–39 years, 40–49 years, 50–59 years, and 60 years and older]. We used the medication possession ratio to assess adherence and analysis of covariance to measure the adjusted change in CD4+ T cell count during ART. Using Cox proportional hazard regression, we examined the association of age with death and LTFU. In a secondary analysis, we repeated models with age as a continuous variable. Among 92,130 HIV-infected adults who initiated ART, the median age was 34 years and 6,281 (6.8%) were aged ≥50 years. Compared with 16–29 year olds, 40–49 year olds (–46 cells/mm3), 50–59 year olds (–53 cells/mm3), and 60+ year olds (–60 cells/mm3) had reduced CD4+ T cell gains during ART. The adjusted hazard ratio (AHR) for death was increased for individuals aged ≥40 years (AHR 1.25 for 40–49 year olds, 1.56 for 50–59 year olds, and 2.97 for 60+ year olds). Adherence and retention in care were poorest among 16–29 year olds but similar in other groups. As a continuous variable, a 5-year increase in age predicted reduced CD4+ T cell count recovery and increased risk of death. Increased age at ART initiation was associated with poorer clinical outcomes, while age <30 years was associated with a higher likelihood of being lost to follow-up. HIV treatment guidelines should consider age-specific recommendations. PMID:24998881

  16. Chemical hazards in aeromedical aircraft.

    PubMed

    Tupper, C R

    1989-01-01

    Several potentially hazardous chemicals are required to make modern military aircraft fly. With each airevac mission, the possibility exists for structural failure of a fluid system, resulting in contamination to flight/medical crews, patients, and passengers. Aeromedical Evacuation Crewmembers (AECMs) need to be aware of the hazardous chemicals used in aircraft and areas where there is an increased risk to those in and around the aircraft. This study identified potential areas for chemical leakage, such as refuel receptacles, hydraulic reservoirs, hydraulic motors, doors, ramps, engines, and more. Further, it identified the basic first aid procedures to perform on people contaminated with jet fuel, hydraulic fluid, engine oil, fire extinguisher agents, LOX and other fluids. First aid procedures are basic and can be performed with supplies and equipment on a routine aeromedical evacuation mission, AECMs trained in a basic awareness of hazardous aircraft chemicals will result in crews better prepared to cope with the unique risks of transporting patients in a complicated military aircraft.

  17. Chemical hazards in aeromedical aircraft.

    PubMed

    Tupper, C R

    1989-01-01

    Several potentially hazardous chemicals are required to make modern military aircraft fly. With each airevac mission, the possibility exists for structural failure of a fluid system, resulting in contamination to flight/medical crews, patients, and passengers. Aeromedical Evacuation Crewmembers (AECMs) need to be aware of the hazardous chemicals used in aircraft and areas where there is an increased risk to those in and around the aircraft. This study identified potential areas for chemical leakage, such as refuel receptacles, hydraulic reservoirs, hydraulic motors, doors, ramps, engines, and more. Further, it identified the basic first aid procedures to perform on people contaminated with jet fuel, hydraulic fluid, engine oil, fire extinguisher agents, LOX and other fluids. First aid procedures are basic and can be performed with supplies and equipment on a routine aeromedical evacuation mission, AECMs trained in a basic awareness of hazardous aircraft chemicals will result in crews better prepared to cope with the unique risks of transporting patients in a complicated military aircraft. PMID:2923600

  18. Health hazards of welding fumes.

    PubMed

    Meo, Sultan A; Al-Khlaiwi, Thamir

    2003-11-01

    Even in the twenty-first century, welding is still a common and a highly skilled occupation. The hazardous agents associated with welding processes are acetylene, carbon monoxide, oxides of nitrogen, ozone, phosgene, tungsten, arsenic, beryllium, cadmium, chromium, cobalt, copper, iron, lead, manganese, nickel, silver, tin, and zinc. All welding processes involve the potential hazards for inhalation exposures that may lead to acute or chronic respiratory diseases. According to literature described earlier it has been suggested that welding fumes cause the lung function impairment, obstructive and restrictive lung disease, cough, dyspnea, rhinitis, asthma, pneumonitis, pneumoconiosis, carcinoma of the lungs. In addition, welding workers suffer from eye irritation, photokeratitis, cataract, skin irritation, erythema, pterygium, non-melanocytic skin cancer, malignant melanoma, reduced sperm count, motility and infertility. Most of the studies have been attempted previously to evaluate the effects of welding fumes. However, no collectively effort illuminating the general effects of welding fumes on different organs or systems or both in human has not been published. Therefore, the aim of this review is to gather the potential toxic effects of welding fumes documented by individual efforts and provide informations to community on hazards of welding.

  19. Asbestos products, hazards, and regulation.

    PubMed

    Castleman, Barry

    2006-01-01

    Asbestos is present in the United States in a multitude of products used in past decades, and in some products that continue to be imported and domestically produced. We have limited information on the hazards posed by some of these individual products and no information at all on most of them. Legal discovery of corporate documents has shed some light on the use of asbestos in some products and exposures from asbestos in others, sometimes adding considerably to what was in the published literature. But liability concerns have motivated corporate efforts to curtail governmental public health guidance on long-recognized hazards to workers. Liability considerations have also evidently led, in the case of asbestos brake linings, to the support of publication in the scientific literature of review articles denying in the 21st century what had been widely accepted and established in health policy in the 20th century. This report is an effort to illustrate the suppression and emergence of scientific knowledge in a climate of regulation and liability. Examples discussed are vinyl-asbestos flooring, feminine hygiene products, automotive friction materials, and asbestos contamination of other minerals such as talc and vermiculite. Global efforts to deal with the hazards of continuing marketing of asbestos products are also discussed. PMID:16878394

  20. Hazardous Compounds in Tobacco Smoke

    PubMed Central

    Talhout, Reinskje; Schulz, Thomas; Florek, Ewa; van Benthem, Jan; Wester, Piet; Opperhuizen, Antoon

    2011-01-01

    Tobacco smoke is a toxic and carcinogenic mixture of more than 5,000 chemicals. The present article provides a list of 98 hazardous smoke components, based on an extensive literature search for known smoke components and their human health inhalation risks. An electronic database of smoke components containing more than 2,200 entries was generated. Emission levels in mainstream smoke have been found for 542 of the components and a human inhalation risk value for 98 components. As components with potential carcinogenic, cardiovascular and respiratory effects have been included, the three major smoke-related causes of death are all covered by the list. Given that the currently used Hoffmann list of hazardous smoke components is based on data from the 1990s and only includes carcinogens, it is recommended that the current list of 98 hazardous components is used for regulatory purposes instead. To enable risk assessment of components not covered by this list, thresholds of toxicological concern (TTC) have been established from the inhalation risk values found: 0.0018 μg day−1 for all risks, and 1.2 μg day−1 for all risks excluding carcinogenicity, the latter being similar to previously reported inhalation TTCs. PMID:21556207

  1. 14 CFR 417.413 - Hazard areas.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Hazard areas. 417.413 Section 417.413... TRANSPORTATION LICENSING LAUNCH SAFETY Ground Safety § 417.413 Hazard areas. (a) General. A launch operator must define a hazard area that confines the adverse effects of a hardware system should an event occur...

  2. 14 CFR 437.55 - Hazard analysis.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Hazard analysis. 437.55 Section 437.55... TRANSPORTATION LICENSING EXPERIMENTAL PERMITS Safety Requirements § 437.55 Hazard analysis. (a) A permittee must... safety of property resulting from each permitted flight. This hazard analysis must— (1) Identify...

  3. 14 CFR 437.55 - Hazard analysis.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Hazard analysis. 437.55 Section 437.55... TRANSPORTATION LICENSING EXPERIMENTAL PERMITS Safety Requirements § 437.55 Hazard analysis. (a) A permittee must... safety of property resulting from each permitted flight. This hazard analysis must— (1) Identify...

  4. 14 CFR 437.55 - Hazard analysis.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Hazard analysis. 437.55 Section 437.55... TRANSPORTATION LICENSING EXPERIMENTAL PERMITS Safety Requirements § 437.55 Hazard analysis. (a) A permittee must... safety of property resulting from each permitted flight. This hazard analysis must— (1) Identify...

  5. 14 CFR 437.55 - Hazard analysis.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Hazard analysis. 437.55 Section 437.55... TRANSPORTATION LICENSING EXPERIMENTAL PERMITS Safety Requirements § 437.55 Hazard analysis. (a) A permittee must... safety of property resulting from each permitted flight. This hazard analysis must— (1) Identify...

  6. 78 FR 52956 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-27

    ... Register (78 FR 36220-36222) a proposed flood hazard determination notice that contained an erroneous table... FR 36220. The table provided here represents the proposed flood hazard determinations and communities... . In the proposed flood hazard determination notice published at 78 FR 36220 in the June 17,...

  7. Natural Hazards within the West Indies.

    ERIC Educational Resources Information Center

    Cross, John A.

    1992-01-01

    Outlines the vulnerability of the West Indies to various natural hazards, especially hurricanes, earthquakes, and volcanic eruptions. Reviews the geologic and meteorologic causes and consequences of the hazards. Suggests methods of incorporating hazards information in geography classes. Includes maps and a hurricane tracking chart. (DK)

  8. 49 CFR 171.3 - Hazardous waste.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... have identification numbers which must be displayed on hazardous waste manifests. See 40 CFR parts 262...: In 40 CFR part 263, the EPA sets forth requirements for the cleanup of releases of hazardous wastes. ... 49 Transportation 2 2010-10-01 2010-10-01 false Hazardous waste. 171.3 Section...

  9. 49 CFR 171.3 - Hazardous waste.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... have identification numbers which must be displayed on hazardous waste manifests. See 40 CFR parts 262...: In 40 CFR part 263, the EPA sets forth requirements for the cleanup of releases of hazardous wastes. ... 49 Transportation 2 2011-10-01 2011-10-01 false Hazardous waste. 171.3 Section...

  10. Hazardous Waste and You. A Teacher's Guide.

    ERIC Educational Resources Information Center

    Ontario Waste Management Corp., Toronto.

    This teaching guide provides an interactive introduction to hazardous waste, with particular emphasis on personal responsibility and action. Nine lessons engage advanced grade 10 and grade 11-12 science students in group discussions and actions that help them develop awareness of hazardous waste, understanding of the hazardous waste situation in…

  11. 14 CFR 437.29 - Hazard analysis.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Hazard analysis. 437.29 Section 437.29... TRANSPORTATION LICENSING EXPERIMENTAL PERMITS Requirements to Obtain an Experimental Permit Operational Safety Documentation § 437.29 Hazard analysis. (a) An applicant must perform a hazard analysis that complies with §...

  12. 14 CFR 417.413 - Hazard areas.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Hazard areas. 417.413 Section 417.413 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH SAFETY Ground Safety § 417.413 Hazard areas. (a) General. A launch operator must define a hazard area that confines...

  13. "Only When You Know the Hazards..."

    ERIC Educational Resources Information Center

    Jacobsen, Erica K.

    2005-01-01

    The disposal of hazardous chemicals and chemical containing products is of much concern and there is a need for a document that describes the hazards of a chemical, to consider the precautionary measures to be taken. Many classic demonstrations however cannot be performed due to safety concerns since sometimes chemicals are deemed too hazardous or…

  14. 49 CFR 171.3 - Hazardous waste.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... have identification numbers which must be displayed on hazardous waste manifests. See 40 CFR parts 262...: In 40 CFR part 263, the EPA sets forth requirements for the cleanup of releases of hazardous wastes. ... 49 Transportation 2 2013-10-01 2013-10-01 false Hazardous waste. 171.3 Section...

  15. 49 CFR 171.3 - Hazardous waste.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... have identification numbers which must be displayed on hazardous waste manifests. See 40 CFR parts 262...: In 40 CFR part 263, the EPA sets forth requirements for the cleanup of releases of hazardous wastes. ... 49 Transportation 2 2012-10-01 2012-10-01 false Hazardous waste. 171.3 Section...

  16. 49 CFR 171.3 - Hazardous waste.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... have identification numbers which must be displayed on hazardous waste manifests. See 40 CFR parts 262...: In 40 CFR part 263, the EPA sets forth requirements for the cleanup of releases of hazardous wastes. ... 49 Transportation 2 2014-10-01 2014-10-01 false Hazardous waste. 171.3 Section...

  17. Augmented Reality Cues and Elderly Driver Hazard Perception

    PubMed Central

    Schall, Mark C.; Rusch, Michelle L.; Lee, John D.; Dawson, Jeffrey D.; Thomas, Geb; Aksan, Nazan; Rizzo, Matthew

    2013-01-01

    Objective Evaluate the effectiveness of augmented reality (AR) cues in improving driving safety in elderly drivers who are at increased crash risk due to cognitive impairments. Background Cognitively challenging driving environments pose a particular crash risk for elderly drivers. AR cueing is a promising technology to mitigate risk by directing driver attention to roadway hazards. This study investigates whether AR cues improve or interfere with hazard perception in elderly drivers with age-related cognitive decline. Methods Twenty elderly (Mean= 73 years, SD= 5 years), licensed drivers with a range of cognitive abilities measured by a speed of processing (SOP) composite participated in a one-hour drive in an interactive, fixed-base driving simulator. Each participant drove through six, straight, six-mile-long rural roadway scenarios following a lead vehicle. AR cues directed attention to potential roadside hazards in three of the scenarios, and the other three were uncued (baseline) drives. Effects of AR cueing were evaluated with respect to: 1) detection of hazardous target objects, 2) interference with detecting nonhazardous secondary objects, and 3) impairment in maintaining safe distance behind a lead vehicle. Results AR cueing improved the detection of hazardous target objects of low visibility. AR cues did not interfere with detection of nonhazardous secondary objects and did not impair ability to maintain safe distance behind a lead vehicle. SOP capacity did not moderate those effects. Conclusion AR cues show promise for improving elderly driver safety by increasing hazard detection likelihood without interfering with other driving tasks such as maintaining safe headway. PMID:23829037

  18. Sex ratio of China's population deserves attention.

    PubMed

    Zeng, Y; Tu, P; Gu, B; Xu, Y; Li, B; Li, Y

    1992-12-01

    A paper on the sex ratio at birth in China was presented at the international seminar on China's 1990 population census held during October 19-23, 1992 in Beijing. The normal sex ratio at birth is 106 male births/100 female births, which was the ratio in China in the 1960s and 1970s. However, in 1981 it increased to 108.5, then to 110.9 in 1986, to 111.0 in 1987, and to 113.8 in 1989. The sex ratios at ages 0-4 years were 107.0 in 1953, 106.2 in 1964, 107.1 in 1982, and 110.2 in 1990. The sex ratio at birth in 1989 was 105 for 1st parity births, but reached 120.9, 124.6, and 131.7 for 2nd, 3rd, 4th and higher parity births, respectively. The analysis of data from the 1990 National Census, the 1987 One Percent Population Sample Survey, and the 1988 Two-Per-Thousand Population Sampling Survey revealed that a serious underreporting of female births and increased illegal prenatal sex identification were the most important causes of the increase in the sex ratio at birth. The sex differential in underreporting births accounted for at least 42.6-51.3% of the difference between the normal value of 106 and the actual sex ratio at birth reported in the 1990 census. Data from the 1988 Two-Per-Thousand Population Sampling Survey showed that rate of underreporting of female births twice exceeded that of male births in the years between 1983 and 1988. The underreporting accounted for 54-88% of the difference between the normal value and the reported sex ratios. A great number of B ultrasonic scanning machines were introduced after 1982 in clinics and family planning service stations. Although they are not meant for nonmedical purposes, enforcement of rules is difficult in view of the preference for sons. Medical records of 1,243,284 pregnancies surveyed for birth defects at 945 hospitals indicated sex ratios of 108.0, 108.3, 109.1, and 109.7 in 1988, 1989, 1990, and 1991, respectively. Underreporting rather than female infanticide is probably the main cause of these increasing

  19. Lidar ratio and depolarization ratio for cirrus clouds.

    PubMed

    Chen, Wei-Nai; Chiang, Chih-Wei; Nee, Jan-Bai

    2002-10-20

    We report on studies of the lidar and the depolarization ratios for cirrus clouds. The optical depth and effective lidar ratio are derived from the transmission of clouds, which is determined by comparing the backscattering signals at the cloud base and cloud top. The lidar signals were fitted to a background atmospheric density profile outside the cloud region to warrant the linear response of the return signals with the scattering media. An average lidar ratio, 29 +/- 12 sr, has been found for all clouds measured in 1999 and 2000. The height and temperature dependences ofthe lidar ratio, the optical depth, and the depolarization ratio were investigated and compared with results of LITE and PROBE. Cirrus clouds detected near the tropopause are usually optically thin and mostly subvisual. Clouds with the largest optical depths were found near 12 km with a temperature of approximately -55 degrees C. The multiple-scattering effect is considered for clouds with high optical depths, and this effect lowers the lidar ratios compared with a single-scattering condition. Lidar ratios are in the 20-40 range for clouds at heights of 12.5-15 km and are smaller than approximately 30 in height above 15 km. Clouds are usually optically thin for temperatures below approximately -65 degrees C, and in this region the optical depth tends to decrease with height. The depolarization ratio is found to increase with a height at 11-15 km and smaller than 0.3 above 16 km. The variation in the depolarization ratio with the lidar ratio was also reported. The lidar and depolarization ratios were discussed in terms of the types of hexagonal ice crystals.

  20. 21 CFR 123.6 - Hazard analysis and Hazard Analysis Critical Control Point (HACCP) plan.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... identified food safety hazards, including as appropriate: (i) Critical control points designed to control... control points designed to control food safety hazards introduced outside the processing plant environment... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Hazard analysis and Hazard Analysis...

  1. 76 FR 37283 - Hazardous Materials: Revision to the List of Hazardous Substances and Reportable Quantities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-27

    ... TRANSPORTATION Pipeline and Hazardous Materials Safety Administration 49 CFR Part 172 RIN 2137-AE74 Hazardous... materials under the Federal hazardous materials transportation law (49 U.S.C. 5101-5128). PHMSA carries out... Federal hazardous materials transportation law (49 U.S.C. 5101 et seq.), which authorizes the......

  2. 78 FR 69310 - Hazardous Materials Table, Special Provisions, Hazardous Materials Communications, Emergency...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ... Pipeline and Hazardous Materials Safety Administration 49 CFR Part 172 Hazardous Materials Table, Special Provisions, Hazardous Materials Communications, Emergency Response Information, Training Requirements, and... of October 1, 2012, on page 242, in Sec. 172.101, in the Hazardous Materials Table, in the entry...

  3. Toxicological evaluation for the hazard assessment of tire crumb for use in public playgrounds.

    PubMed

    Birkholz, Detlef A; Belton, Kathy L; Guidotti, Tee L

    2003-07-01

    Disposal of used tires has been a major problem in solid waste management. New uses will have to be found to consume recycled tire products. One such proposed use is as ground cover in playgrounds. However, concern has been expressed regarding exposure of children to hazardous chemicals and the environmental impact of such chemicals. We designed a comprehensive hazard assessment to evaluate and address potential human health and environmental concerns associated with the use of tire crumb in playgrounds. Human health concerns were addressed using conventional hazard analyses, mutagenicity assays, and aquatic toxicity tests of extracted tire crumb. Hazard to children appears to be minimal. Toxicity to all aquatic organisms (bacteria, invertebrates, fish, and green algae) was observed; however, this activity disappeared with aging of the tire crumb for three months in place in the playground. We conclude that the use of tire crumb in playgrounds results in minimal hazard to children and the receiving environment.

  4. The postoperative neutrophil-to-lymphocyte ratio and changes in this ratio predict survival after the complete resection of stage I non-small cell lung cancer

    PubMed Central

    Jin, Feng; Han, Anqin; Shi, Fang; Kong, Li; Yu, Jinming

    2016-01-01

    Purpose Although numerous studies have demonstrated associations between the preoperative neutrophil-to-lymphocyte ratio (NLR) and long-term outcomes in patients with non-small cell lung cancer (NSCLC), the prognostic significance of postoperative NLR and change in NLR (ΔNLR) is unknown for patients who underwent complete resection of stage I NSCLC. The aim of this retrospective study was to evaluate the prognostic significance of postoperative NLR and ΔNLR in 123 patients with stage I NSCLC. Patients and methods This retrospective study included preoperative and postoperative data of 123 patients who underwent surgical resection for stage I NSCLC. The relationship between disease-free survival (DFS), overall survival (OS), and clinicopathological factors, including NLR, lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio, and their changes, was analyzed using both univariate Kaplan–Meier and multivariate Cox regression methods. Results The 5-year DFS and OS rates in our cohort were 60.16% and 67.48%, respectively. Univariate analysis revealed that age (P=0.045), smoking status (P=0.033), preoperative NLR (P=0.032), postoperative NLR (P<0.001), ΔNLR (P=0.004), and change in LMR (ΔLMR) (P=0.025) were significant predictors of DFS and that age (P=0.039), smoking status (P=0.042), postoperative NLR (P<0.001), ΔNLR (P=0.004), and ΔLMR (P=0.011) were independent predictors of OS. Multivariate analysis confirmed that postoperative NLR (hazard ratio [HR] =2.435, P=0.001) and ΔNLR (HR =2.103, P=0.012) were independent predictors of DFS and that postoperative NLR (HR =2.747, P=0.001) and ΔNLR (HR =2.052, P=0.018) were significant prognostic factors of OS. Conclusion Our study reported for the first time that postoperative NLR and ΔNLR – but not preoperative NLR – were independent prognostic factors of DFS and OS in patients with stage I NSCLC who underwent complete resection. This easily available biomarker might be helpful in individual risk

  5. Relation Between Serum Total Cholesterol Level and Cardiovascular Disease Stratified by Sex and Age Group: A Pooled Analysis of 65 594 Individuals From 10 Cohort Studies in Japan

    PubMed Central

    Nagasawa, Sin-ya; Okamura, Tomonori; Iso, Hiroyasu; Tamakoshi, Akiko; Yamada, Michiko; Watanabe, Makoto; Murakami, Yoshitaka; Miura, Katsuyuki; Ueshima, Hirotsugu

    2012-01-01

    Background The relation between serum total cholesterol (TC) and cardiovascular disease in women and in the elderly is unclear, especially in Asian populations. Methods and Results We examined this relation in the largest-scale pooled analysis of the Japanese population, the Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN) study. A total of 65 594 participants who were 40 to 89 years of age and did not have a past history of cardiovascular disease were examined. Cox proportional-hazards models were used to estimate hazard ratios for death from total stroke, cerebral infarction, intracranial cerebral hemorrhage, or coronary heart disease. The mean follow-up period was 10.1 years, with the number of deaths from total stroke, cerebral infarction, cerebral hemorrhage, and coronary heart disease being 875, 457, 212, and 374, respectively. The participants were divided into 2 age groups: middle-aged (40 to 69 years; mean age 55 years) and elderly (70 to 89 years; mean age 75 years). In men, the multivariate-adjusted hazard ratios for coronary heart disease in the highest TC category (≥6.21 mmol/L) compared with the lowest category (<4.14 mmol/L) were 2.52 (95% confidence interval: 1.15–5.07) in middle-aged participants and 2.77 (1.09–7.03) in elderly participants. In women, the hazard ratios of the highest TC category (≥6.72 mmol/L) compared with the lowest category (<4.66 mmol/L) were 3.20 (1.44–7.09) in middle-aged participants and 1.02 (0.42–2.49) in elderly participants. TC levels were not associated with cerebral infarction in any age or sex group and were associated negatively with total stroke and cerebral hemorrhage. Conclusion High serum TC levels are associated with coronary heart disease in middle-aged Japanese men and women, but evidence in elderly Japanese individuals is still limited. PMID:23316288

  6. Mercury and Hazardous Chemicals in Schools: A Manual for Students in Southeast Asia. EPA 747-R-08-002

    ERIC Educational Resources Information Center

    US Environmental Protection Agency, 2008

    2008-01-01

    Children and adolescents, up to approximately age 20, are more susceptible than adults to potential health risks from chemicals and environmental hazards. Hazardous chemicals can interrupt or alter the normal development of a child's body, leading to lasting damage. Since children are smaller than adults, similar levels of exposure to toxic…

  7. Air/fuel ratio controller

    SciTech Connect

    Schechter, M.M.; Simko, A.O.

    1980-12-23

    An internal combustion engine has a fuel injection pump and an air/fuel ratio controller. The controller has a lever that is connected to the pump lever. An aneroid moves the controller lever as a function of changes in intake manifold vacuum to maintain a constant air/fuel ratio to the mixture charge. A fuel enrichment linkage is provided that modifies the movement of the fuel flow control lever by the aneroid in response to changes in manifold gas temperature levels and exhaust gas recirculation to maintain the constant air/fuel ratio. A manual override is provided to obtain a richer air/fuel ratio for maximum acceleration.

  8. Earlier Age of Onset of Chronic Hypertension and Type 2 Diabetes Mellitus After a Hypertensive Disorder of Pregnancy or Gestational Diabetes Mellitus.

    PubMed

    Heida, Karst Y; Franx, Arie; van Rijn, Bas B; Eijkemans, Marinus J C; Boer, Jolanda M A; Verschuren, Monique W M; Oudijk, Martijn A; Bots, Michiel L; van der Schouw, Yvonne T

    2015-12-01

    A prospective cohort study was conducted to assess the impact of a history of hypertensive disorder of pregnancy (HDP) or gestational diabetes mellitus (GDM) on the risk and age of onset of hypertension, type 2 diabetes mellitus (T2D), and cardiovascular disease (CVD) later in life, independent of hypertension and T2D. Between 1993 and 1997, 22 265 ever-pregnant women were included from the European Prospective Investigation into Cancer and Nutrition-NL study, aged 20 to 70 years at baseline. Details on complications of pregnancy and known hypertension were obtained by questionnaire. Blood pressure was measured at enrollment. Participants were followed for the occurrence of CVD events. Data were analyzed using ANCOVA, multivariable logistic regression, and Cox proportional hazard (with HDP and GDM as time-dependent variables for T2D and CVD) models. At enrollment, women with a HDP reported diagnosis of hypertension 7.7 years earlier (95% confidence interval [CI] 6.9-8.5) and women with GDM reported diagnosis of T2D 7.7 years earlier (95% CI 5.8-9.6) than women without pregnancy complications. After adjustment for potential confounders, HDP was associated with presence of hypertension at enrollment (odds ratio 2.12, 95% CI 1.98-2.28) and onset of CVD later in life (hazard ratio 1.21, 95% CI 1.10-1.32). After including the intermediates hypertension and T2D in the model, the risk of CVD later in life decreased (hazard ratio 1.09, 95% CI 1.00-1.20). GDM was associated with an increased risk of developing T2D later in life (hazard ratio 3.68, 95% CI 2.77-4.90), but not with risk of CVD. HDP and GDM have a substantial impact on the risk of CVD and are potentially important indicators for preventive cardiovascular risk management.

  9. Multi-Hazard Sustainability: Towards Infrastructure Resilience

    NASA Astrophysics Data System (ADS)

    Lin, T.

    2015-12-01

    Natural and anthropogenic hazards pose significant challenges to civil infrastructure. This presents opportunities in investigating site-specific hazards in structural engineering to aid mitigation and adaptation efforts. This presentation will highlight: (a) recent advances in hazard-consistent ground motion selection methodology for nonlinear dynamic analyses, (b) ongoing efforts in validation of earthquake simulations and their effects on tall buildings, and (c) a pilot study on probabilistic sea-level rise hazard analysis incorporating aleatory and epistemic uncertainties. High performance computing and visualization further facilitate research and outreach to improve resilience under multiple hazards in the face of climate change.

  10. The Abundance Ratio Pattern in Elliptical Galaxies

    NASA Astrophysics Data System (ADS)

    Worthey, Guy

    1995-12-01

    Non-solar abundance ratios in elliptical galaxies are readily detectable in a qualitative sense. The elements Mg, Na, and N appear overabundant compared to Ca and Fe. There is a probable variation of (Sc + V)/Ti. Abundance ratio effects are the single most serious barrier to the estimation of mean stellar ages: even more serious than the 35% model-to-model uncertainty. Isochrone grids allowing for the variation of many individual elements (He, O, C, and N at least, in addition to overall Z and alpha elements) are needed to quantitatively estimate the overabundances and mean ages of ellipticals. The tolerances for relative shifts in isochrone temperatures are tight: about 7 K if we hope for 5% accurate ages. The abundance pattern in elliptical galaxies matches neither the disk, nor the halo, nor the bulge our own Galaxy, although the bulge appears to provide the best match. This research was funded by NASA through grant HF-1066.01-94A from the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555.

  11. NASA LaRC Hazardous Material Pharmacy

    NASA Technical Reports Server (NTRS)

    Esquenet, Remy

    1995-01-01

    In 1993-1994 the Office of Environmental Engineering contracted SAIC to develop NASA Langley's Pollution Prevention (P2) Program. One of the priority projects identified in this contract was the development of a hazardous waste minimization (HAZMIN)/hazardous materials reutilization (HAZMART) program in the form of a Hazardous Materials Pharmacy. A hazardous materials pharmacy is designed to reduce hazardous material procurement costs and hazardous waste disposal costs. This is accomplished through the collection and reissue of excess hazardous material. Currently, a rarely used hazardous material may be stored in a shop area, unused, until it passes its expiration date. The material is then usually disposed of as a hazardous waste, often at a greater expense than the original cost of the material. While this material was on the shelf expiring, other shop areas may have ordered new supplies of the same material. The hazardous material pharmacy would act as a clearinghouse for such materials. Material that is not going to be used would be turned in to the pharmacy. Other users could then be issued this material free of charge, thereby reducing procurement costs. The use of this material by another shop prevents it from expiring, thereby reducing hazardous waste disposal costs.

  12. Hazardous materials in Fresh Kills landfill

    SciTech Connect

    Hirschhorn, J.S.

    1997-12-31

    No environmental monitoring and corrective action programs can pinpoint multiple locations of hazardous materials the total amount of them in a large landfill. Yet the consequences of hazardous materials in MSW landfills are considerable, in terms of public health concerns, environmental damage, and cleanup costs. In this paper a rough estimation is made of how much hazardous material may have been disposed in Fresh Kills landfill in Staten Island, New York. The logic and methods could be used for other MSW landfills. Fresh Kills has frequently been described as the world`s largest MSW landfill. While records of hazardous waste disposal at Fresh Kills over nearly 50 years of operation certainly do not exist, no reasonable person would argue with the conclusion that large quantities of hazardous waste surely have been disposed at Fresh Kills, both legally and illegally. This study found that at least 2 million tons of hazardous wastes and substances have been disposed at Fresh Kills since 1948. Major sources are: household hazardous waste, commercial RCRA hazardous waste, incinerator ash, and commercial non-RCRA hazardous waste, governmental RCRA hazardous waste. Illegal disposal of hazardous waste surely has contributed even more. This is a sufficient amount to cause serious environmental contamination and releases, especially from such a landfill without an engineered liner system, for example. This figure is roughly 1% of the total amount of waste disposed in Fresh Kills since 1948, probably at least 200 million tons.

  13. Implementation of the hazardous debris rule

    SciTech Connect

    Sailer, J.E.

    1993-01-05

    Hazardous debris includes objects contaminated with hazardous waste. Examples of debris include tree stumps, timbers, boulders, tanks, piping, crushed drums, personal protective clothing, etc. Most of the hazardous debris encountered comes from Superfund sites and other facility remediation, although generators and treaters of hazardous waste also generate hazardous debris. Major problems associated with disposal of debris includes: Inappropriateness of many waste treatments to debris; Difficulties in obtaining representative samples; Costs associated with applying waste specific treatments to debris; Subtitle C landfill space was being used for many low hazard debris types. These factors brought about the need for debris treatment technologies and regulations that addressed these issues. The goal of such regulation was to provide treatment to destroy or remove the contamination if possible and, if this is achieved, to dispose of the cleaned debris as a nonhazardous waste. EPA has accomplished this goal through promulgation of the Hazardous Debris Rule, August 18, 1992.

  14. Muscle: Bone ratios in beef rib sections.

    PubMed

    Dolezal, H G; Murphey, C E; Smith, G C; Carpenter, Z L; McCartor, M

    1982-01-01

    Thirty-eight steers and thirty heifers (14 to 17 months of age, from F(1) Hereford × Brahman cows bred to Angus or Hereford bulls), were either forage-fed for 123 days on millet-bermudagrass pasture or grain-fed for 90 days on a high-concentrate diet and were then commercially slaughtered. Warm carcass weights ranged from 167·8 kg to 324·3 kg. At 24 h post mortem, Texas Agricultural Experiment Station personnel (1) assigned scores or took measurements on each carcass for all factors used in yield grading and quality grading, (2) measured the length of hind leg (HL) and carcass length (CL) and (3) assigned a score for carcass muscling (MS) and, as appropriate, made an adjusted longissimus muscle area (ALA) evaluation. The 9th-10th-11th rib section from one side of each carcass was physically separated into longissimus muscle, fat, 'other soft tissue' and bone and ether extract determinations of the longissimus muscle and 'other soft tissue' components were made and used to adjust the yields of each of these components to a fat-free basis. Muscle to bone ratios ranged from 2·38 to 4·37. With both age and carcass weight held constant, diet, breed and sex explained only 35·8% of the variation in muscle to bone ratio. The best simple correlation with muscle to bone ratio was ALA/CL (r = ·59). Other measures significantly correlated with muscle to bone ratio included ALA (r = 0·55), MS (r = 0·50) and carcass weight (r = 0·49). Multiple regression analyses identified a three-variable subset comprised of ALA, carcass weight and CL which was related (P < 0·01) to muscle to bone ratio R(2) = 0·41). Data suggest that muscle to bone ratios differ widely among beef carcasses of similar genetic-management history and that there are carcass measures useful for predicting muscle to bone ratio. PMID:22054706

  15. Muscle: Bone ratios in beef rib sections.

    PubMed

    Dolezal, H G; Murphey, C E; Smith, G C; Carpenter, Z L; McCartor, M

    1982-01-01

    Thirty-eight steers and thirty heifers (14 to 17 months of age, from F(1) Hereford × Brahman cows bred to Angus or Hereford bulls), were either forage-fed for 123 days on millet-bermudagrass pasture or grain-fed for 90 days on a high-concentrate diet and were then commercially slaughtered. Warm carcass weights ranged from 167·8 kg to 324·3 kg. At 24 h post mortem, Texas Agricultural Experiment Station personnel (1) assigned scores or took measurements on each carcass for all factors used in yield grading and quality grading, (2) measured the length of hind leg (HL) and carcass length (CL) and (3) assigned a score for carcass muscling (MS) and, as appropriate, made an adjusted longissimus muscle area (ALA) evaluation. The 9th-10th-11th rib section from one side of each carcass was physically separated into longissimus muscle, fat, 'other soft tissue' and bone and ether extract determinations of the longissimus muscle and 'other soft tissue' components were made and used to adjust the yields of each of these components to a fat-free basis. Muscle to bone ratios ranged from 2·38 to 4·37. With both age and carcass weight held constant, diet, breed and sex explained only 35·8% of the variation in muscle to bone ratio. The best simple correlation with muscle to bone ratio was ALA/CL (r = ·59). Other measures significantly correlated with muscle to bone ratio included ALA (r = 0·55), MS (r = 0·50) and carcass weight (r = 0·49). Multiple regression analyses identified a three-variable subset comprised of ALA, carcass weight and CL which was related (P < 0·01) to muscle to bone ratio R(2) = 0·41). Data suggest that muscle to bone ratios differ widely among beef carcasses of similar genetic-management history and that there are carcass measures useful for predicting muscle to bone ratio.

  16. Worrying About Terrorism and Other Acute Environmental Health Hazard Events

    PubMed Central

    Babcock-Dunning, Lauren

    2012-01-01

    Objectives. To better understand why some people worry more about terrorism compared with others, we measured how much US residents worried about a terrorist event in their area and examined the association of their fears with their concerns about acute and chronic hazards and other correlates. Methods. In 2008 (n = 600) and 2010 (n = 651), we performed a random-digit dialing national landline telephone survey. We asked about worries about terrorism and 5 other environmental health hazard issues. We also collected demographic and socioeconomic data. Results. Only 15% worried “a great deal” about a terrorist event in their area and 18% to 33% were greatly concerned about other environmental issues. Fear about acute hazard events was a stronger predictor of a great deal of concern about terrorism than were age, race/ethnicity, gender, educational achievement, and other correlates. Conclusions. Those who worried most about acute environmental health hazard events were most likely to worry about terrorism. Also, those who were older, poorer, Blacks, or Latinos, or who lived in populous urban areas felt they were most vulnerable to terrorist attacks. We recommend methods to involve US citizens as part of disaster planning. PMID:22397346

  17. Map showing lava-flow hazard zones, Island of Hawaii

    USGS Publications Warehouse

    Wright, Thomas L.; Chun, Jon Y.F.; Exposo, Jean; Heliker, Christina; Hodge, Jon; Lockwood, John P.; Vogt, Susan M.

    1992-01-01

    This map shows lava-flow hazard zones for the five volcanoes on the Island of Hawaii. Volcano boundaries are shown as heavy, dark bands, reflecting the overlapping of lava flows from adjacent volcanoes along their common boundary. Hazard-zone boundaries are drawn as double lines because of the geologic uncertainty in their placement. Most boundaries are gradational, and the change In the degree of hazard can be found over a distance of a mile or more. The general principles used to place hazard-zone boundaries are discussed by Mullineaux and others (1987) and Heliker (1990). The differences between the boundaries presented here and in Heliker (1990) reflect new data used in the compilation of a geologic map for the Island of Hawaii (E.W. Wolfe and Jean Morris, unpub. data, 1989). The primary source of information for volcano boundaries and generalized ages of lava flows for all five volcanoes on the Island of Hawaii is the geologic map of Hawaii (E.W. Wolfe and Jean Morris, unpub. data, 1989). More detailed information is available for the three active volcanoes. For Hualalai, see Moore and others (1987) and Moore and Clague (1991); for Mauna Loa, see Lockwood and Lipman (1987); and for Kilauea, see Holcomb (1987) and Moore and Trusdell (1991).

  18. NGNP SITE 2 HAZARDS ASSESSMENT

    SciTech Connect

    Wayne Moe

    2011-10-01

    The Next Generation Nuclear Plant (NGNP) Project initiated at Idaho National Laboratory (INL) by the U.S. Department of Energy pursuant to the 2005 Energy Policy Act, is based on research and development activities supported by the Generation IV Nuclear Energy Systems Initiative. The principal objective of the NGNP Project is to support commercialization of the high temperature gas-cooled reactor (HTGR) technology. The HTGR is a helium-cooled and graphite-moderated reactor that can operate at temperatures much higher than those of conventional light water reactor (LWR) technologies. Accordingly, it can be applied in many industrial applications as a substitute for burning fossil fuels, such as natural gas, to generate process heat in addition to producing electricity, which is the principal application of current LWRs. Nuclear energy in the form of LWRs has been used in the U.S. and internationally principally for the generation of electricity. However, because the HTGR operates at higher temperatures than LWRs, it can be used to displace the use of fossil fuels in many industrial applications. It also provides a carbon emission-free energy supply. For example, the energy needs for the recovery and refining of petroleum, for the petrochemical industry and for production of transportation fuels and feedstocks using coal conversion processes require process heat provided at temperatures approaching 800 C. This temperature range is readily achieved by the HTGR technology. This report summarizes a site assessment authorized by INL under the NGNP Project to determine hazards and potential challenges that site owners and HTGR designers need to be aware of when developing the HTGR design for co-location at industrial facilities, and to evaluate the site for suitability considering certain site characteristics. The objectives of the NGNP site hazard assessments are to do an initial screening of representative sites in order to identify potential challenges and restraints

  19. The scent of age.

    PubMed Central

    Osada, Kazumi; Yamazaki, Kunio; Curran, Maryanne; Bard, Judith; Smith, Benjamin P C; Beauchamp, Gary K

    2003-01-01

    In many species, older males are often preferred mates because they carry 'good' genes that account for their viability. How females discern a male's age is a matter of question. However, for animals that rely heavily on chemical communication there is some indication that an animal's age can be determined by its scent. To investigate whether there are changes in body odours with age, and if so their composition, mice were trained in a Y-maze to discriminate urine odours of donor mice of different ages: Adult (3-10 months old) and Aged (more than 17 months old). Trained mice could discriminate between these two age groups by odour alone. To determine the chemical basis for these discriminations, studies were performed using gas chromatography and mass spectrometry. These analyses demonstrated differences in the ratio of urinary volatiles with age. The most prominent differences involved significantly greater amounts of 2-phenylacetamide and significantly lower amounts of methylbutyric acids in Aged animals relative to Adult animals. Fractionating and manipulating the levels of these compounds in the urine demonstrated that the mice can distinguish age based on variation in amounts of these specific compounds in the combined urine. PMID:12803907

  20. 78 FR 24309 - Pipeline and Hazardous Materials Safety Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-24

    ... Pipeline and Hazardous Materials Safety Administration List of Special Permit Applications Delayed AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: List of Applications Delayed... of Hazardous Materials Special Permits and Approvals, Pipeline and Hazardous Materials...

  1. 76 FR 75950 - Hazardous Materials: Emergency Restriction/Prohibition Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-05

    ... Pipeline and Hazardous Materials Safety Administration Hazardous Materials: Emergency Restriction/Prohibition Order AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION..., including Rainbow of Hope. This Emergency Order was issued by the Office of Hazardous Materials...

  2. 76 FR 45332 - Pipeline and Hazardous Materials Safety Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-28

    ... Pipeline and Hazardous Materials Safety Administration Office of Hazardous Materials Safety; Notice of Applications for Modification of Special Permit AGENCY: Pipeline and Hazardous Materials Safety Administration... Department of Transportation's Hazardous Material Regulations (49 CFR part 107, subpart B), notice is...

  3. 78 FR 34156 - Hazardous Materials: Emergency Recall Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ... Pipeline and Hazardous Materials Safety Administration Hazardous Materials: Emergency Recall Order AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Emergency Recall Order... on May 24, 2013 to The Lite Cylinder Company, Inc. The Office of Hazardous Materials Safety...

  4. 78 FR 18419 - Office of Hazardous Materials Safety; Delayed Applications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... Pipeline and Hazardous Materials Safety Administration Office of Hazardous Materials Safety; Delayed Applications AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: List of... Paquet, Director, Office of Hazardous Materials Special Permits and Approvals, Pipeline and...

  5. Misconceptions about the Golden Ratio.

    ERIC Educational Resources Information Center

    Markowsky, George

    1992-01-01

    Typically, the mathematical properties concerning the golden ratio are stated correctly, but much of what is presented with respect to the golden ratio in art, architecture, literature, and aesthetics is false or seriously misleading. Discussed here are some of the most commonly repeated misconceptions promulgated, particularly within mathematics…

  6. Progressive Ratio Schedules of Reinforcement

    PubMed Central

    Killeen, Peter R.; Posadas-Sanchez, Diana; Johansen, Espen Borgå; Thrailkill, Eric A.

    2009-01-01

    Pigeons’ pecks produced grain under progressive ratio (PR) schedules, whose response requirements increased systematically within sessions. Experiment 1 compared arithmetic (AP) and geometric (GP) progressions. Response rates increased as a function of the component ratio requirement, then decreased linearly (AP) or asymptotically (GP). Experiment 2 found the linear decrease in AP rates to be relatively independent of step size. Experiment 3 showed pausing to be controlled by the prior component length, which predicted the differences between PR and regressive ratio schedules found in Experiment 4. When the longest component ratios were signaled by different key colors, rates at moderate ratios increased, demonstrating control by forthcoming context. Models for response rate and pause duration described performance on AP schedules; GP schedules required an additional parameter representing the contextual reinforcement. PMID:19159161

  7. Introducing a new measure for assessing self-efficacy in response to air pollution hazards for pregnant women

    PubMed Central

    2013-01-01

    A self-efficacy instrument should be condition-specific. There are several instruments for measuring self-efficacy, but none are air pollution-specific. This study aimed to develop a self-efficacy measure for assessing pregnant women’s responses to air pollution hazards. A random sample of pregnant women aged between 18 and 35 years attending three prenatal care centers were entered into the study. Prenatal care centers randomly selected from a list of centers located in different geographical regions of Tehran, Iran. After careful consideration and performing content and face validity, a 4-item measure was developed and participants completed the questionnaire. Reliability was estimated using internal consistency and validity was assessed by performing confirmatory factor analysis (CFA) and known group comparison. In all 200 eligible pregnant women were studied. The mean age of participants was 26.9 (SD = 4.8) years and it was 27.9 (SD = 9.1) weeks for gestational age. The findings showed almost perfect results for both content validity ratio (CVR = 1) and content validity index (CVI = 1). The confirmatory factor analysis indicated a good fit to the data, and known group comparison revealed satisfying results. Internal consistency as measured by the Cronbach’s alpha coefficient was found to be 0.74. In general, the findings suggest that this new generated scale is a reliable and valid specific measure of self-efficacy in response to air pollution hazards for pregnant women. However, further studies are needed to establish stronger psychometric properties for the questionnaire. PMID:24491221

  8. Physical hazards of animal handlers.

    PubMed

    Langley, R

    1999-01-01

    Animal handlers may be harmed on the job due to injuries inflicted by animals; dangers related to the facility, work activities, and equipment; and weather extremes. Traumatic or venomous attacks by animals can result in fatality. Potentially hazardous features of the work environment include fumigation chambers, cage washers, slippery walking surfaces, needles and scalpels, food preparation equipment, noise, radiation, and motor vehicles. Heat- and cold-related injuries are not uncommon. Attention to safety measures is of critical importance in the field of animal handling.

  9. Windsurfing hazard caused by needlefish.

    PubMed

    Rouvillain, J L; Donica, A; Gane, C; Zekhnini, C; Garron, E; Uzel, A P

    2013-11-01

    Very amusing and entertaining for the traveler, marine activities in tropical countries can be dangerous. More and more trauma caused by hazardous marine animals have been reported in recent years in the world, after maritime accidents including water sports like windsurfing, kite surfing, swimming, diving, and injuries caused by sting or contact with a marine animal. Rays and stone-fish frequently cause trauma, but there are not many cases of injury by needlefish. This case reports a case of penetrating wound of the left foot caused by a Caribbean needlefish occurred during a session of windsurfing in Martinique.

  10. Hurricane hazards: a national threat

    USGS Publications Warehouse

    ,

    2005-01-01

    Hurricanes bring destructive winds, storm surge, torrential rain, flooding, and tornadoes. A single storm can wreak havoc on coastal and inland communities and on natural areas over thousands of square miles. In 2005, Hurricanes Katrina, Rita, and Wilma demonstrated the devastation that hurricanes can inflict and the importance of hurricane hazards research and preparedness. More than half of the U.S. population lives within 50 miles of a coast, and this number is increasing. Many of these areas, especially the Atlantic and Gulf coasts, will be in the direct path of future hurricanes. Hawaii is also vulnerable to hurricanes.

  11. [[A study on sex ratio variation in Korea

    PubMed

    Baeg, K S; Lee, S B

    1989-12-01

    "The purpose of this study is to find out the trend of sex ratio variation in [the Republic of] Korea. The data...were derived from the government publications including the Population and Housing Census Reports covering the period of 1960-1985 and the Korea Urbanic Year Book, 1985. The major findings of the study are summarized as follows: The average sex ratio in all age groups is 100.17-101.44 from 1960 through 1980. Sex ratio imbalance was most severe in 1960 due to the Korean War." Sex ratios are compared among urban and rural areas and for industrialized and agricultural areas. (SUMMARY IN ENG)

  12. Computer simulation of industrial hazards1

    PubMed Central

    Knox, E. G.

    1973-01-01

    Knox, E. G. (1973).Brit. J. industr. Med.,30, 54-63. Computer simulation of industrial hazards. A computer simulation system for a range of industrial hazards provided for model experiments which manipulated (a) the sub-structure of an exposed population in terms of age-distributions and levels of exposure, (b) the nature of the dose/response relationship, (c) the latent interval and its variability, (d) normal life-table expectations, and (e) employment turnover rates. The development of the system led to clarification of terms and concepts with ambiguous current usages, notably in relation to latency. Distinction is made between the notions of `biological' and `observable' latent intervals. Hypothetical exercises with the model tested its technical validity and at the same time demonstrated in quantitative terms the relationships between `biological' and `observable' latent intervals, employment turnover rates, total mortalities, and the distribution of illnesses and death between those currently employed in the exposing industry, those employed elsewhere, and those retired. Prospects of success for personnel engineering techniques, which manipulate age-distributions of exposed work people in relation to diseases with long latent intervals, were examined. Published asbestos cancer data were used as a basis for specific model fitting and resulted in a numerical formulation of the exposure/response relationships. Severe exposure results in an increment of risk of death of about 0·02 unit per person per annum for those exposed for around six years, but with higher rates for shorter exposures and lower rates for longer ones. The mean biological latent interval was about 25 years with a coefficient of variation of about 25%. These suppositions explained a range of published data comprehensively and at the same time predicted that (a) persons exposed at severe levels for a working lifetime of 50 years have a 40% risk of dying from asbestos cancer, and (b) industrial

  13. Skin Aging

    MedlinePlus

    ... too. Sunlight is a major cause of skin aging. You can protect yourself by staying out of ... person has smoked. Many products claim to revitalize aging skin or reduce wrinkles, but the Food and ...

  14. Prognostic significance of an apoptotic index and apoptosis/proliferation ratio for patients with high-grade astrocytomas.

    PubMed Central

    Kuriyama, Hiroko; Lamborn, Kathleen R.; O'Fallon, Judith R.; Iturria, N.; Sebo, Thomas; Schaefer, Paul L.; Scheithauer, Bernd W.; Buckner, Jan C.; Kuriyama, Nagato; Jenkins, Robert B.; Israel, Mark A.

    2002-01-01

    We evaluated the association of spontaneous apoptosis and an apoptosis/proliferation index with survival to determine the potential of such measures to serve as predictive markers for patients with glioblastoma multiforme (GBM). We examined the extent of spontaneous apoptosis in tumors from newly diagnosed patients, 75 with GBM and 21 with anaplastic astrocytoma, who were entered on treatment protocols of the North Central Cancer Treatment Group. In the group of GBM patients, those with a higher apoptotic index tended to live longer ( P = 0.04; Cox proportional hazards model including performance score, age, and extent of resection in a multivariate model). We found that the apoptotic index values for anaplastic astrocytoma patients tended to be lower than those in the GBM patients, although with small sample sizes, the result was not statistically significant ( P = 0.1). We also examined expression of the Ki-67 cell proliferation antigen immunohistochemically using the MIB-1 monoclonal antibody. Ki-67 expression did not provide additional information regarding the survival of patients with GBM. In this group of GBM patients, those patients with higher apoptotic index/proliferation ratios had a better prognosis than did those with a low ratio ( P < 0.021, same model as above). These findings suggest that both apoptosis and a cell death/cell proliferation ratio are associated with patient survival, and they may be useful for either the clinical evaluation of patients with GBM or the stratification of patients for treatment evaluation. PMID:12084348

  15. Detoxification of hazardous dust with marine sediment.

    PubMed

    Wei, Yu-Ling; Lin, Chang-Yuan; Wang, H Paul

    2014-08-30

    Hazardous electric arc furnace dust containing dioxins/furans and heavy metals is blended with harbor sediment, fired at 950-1100 °C to prepare lightweight aggregates. Dust addition can lower the sintering temperature by about 100 °C, as compared to a typical industrial process. After firing at 950 °C and 1050 °C, more than 99.85% of dioxins/furans originally present in the dust have been removed and/or destructed in the mix containing a dust/sediment ratio of 50:100. The heavy metals leached from all fired mixes are far below Taiwan EPA legal limits. The particle density of the lightweight aggregates always decreases with increasing firing temperature. Greater addition of the dust results in a considerably lower particle density (mostly <2.0 g cm(-3)) fired at 1050 °C and 1100 °C. However, firing at temperatures lower than 1050 °C produces no successful bloating, leading to a denser particle density (>2.0 g cm(-3)) that is typical of bricks.

  16. Association Between the Neutrophil/Lymphocyte Ratio and Acute Kidney Injury After Cardiovascular Surgery: A Retrospective Observational Study.

    PubMed

    Kim, Won Ho; Park, Ji Young; Ok, Seong-Ho; Shin, Il-Woo; Sohn, Ju-Tae

    2015-10-01

    A high neutrophil-lymphocyte ratio (N/L ratio) was associated with the development of acute kidney injury (AKI) in patients with severe sepsis. We sought to investigate the association between the perioperative N/L ratios and postoperative AKI in patients undergoing high-risk cardiovascular surgery.A retrospective medical chart review was performed of 590 patients who underwent cardiovascular surgeries, including coronary artery bypass, valve replacement, patch closure for atrial or ventricular septal defect and surgery on the thoracic aorta with cardiopulmonary bypass (CPB). Baseline perioperative clinical parameters, including N/L ratios measured before surgery, immediately after surgery, and on postoperative day (POD) one were obtained. Multivariate logistic regression analysis was used to evaluate risk factors.A total of 166 patients (28.1%) developed AKI defined by the KDIGO (kidney disease improving global outcomes) criteria in the first 7 PODs. Independent risk factors for AKI included old age, decreased left ventricular systolic function, preoperative high serum creatinine, low serum albumin and high uric acid levels, intraoperative large transfusion amount, oliguria, hyperglycemia, and elevated N/L ratio measured immediately after surgery and on POD one. The quartiles of immediately postoperative N/L ratio were associated with graded increase in risk of AKI development (fourth quartile [N/L ratio≥10] multivariate odds ratio 5.90, 95% confidence interval [CI] 2.74-12.73; P < 0.001), a longer hospital stay, and a higher in-hospital and 1-year mortality rate (fourth quartile [N/L ratio≥10] adjusted hazard ratio for 1-year mortality [8.40, 95% CI 2.50-28.17]; P < 0.001).In patients undergoing cardiovascular surgery with CPB, elevated N/L ratios in the immediately postoperative period and on POD one were associated with an increased risk of postoperative AKI and 1-year mortality. The N/L ratio, which is easily calculable from routine work-up, can

  17. Radon-hazard potential of Utah

    SciTech Connect

    Black, B.D.; Solomon, B.J. )

    1993-04-01

    Radon is a naturally occurring radioactive gas formed by decay of uranium, and occurs in nearly all geologic materials. Although radon has been shown to be a significant cause of lung cancer in miners, the health hazard from accumulation of radon gas in buildings has only recently been recognized. Indoor-radon hazards depend on both geologic and non-geologic factors. Although non-geologic factors such as construction type, weather, and lifestyles are difficult to measure, geologic factors such as uranium concentration, soil permeability, and depth to ground water can be quantified. Uranium-enriched geologic materials, such as black shales, marine sandstones, and certain granitic, metamorphic, and volcanic rocks, are generally associated with a high radon-hazard potential. Impermeable soil or shallow ground water impedes radon movement and is generally associated with a low radon-hazard potential. A numerical rating system based on these geologic factors has been developed to map radon-hazard potential in Utah. A statewide map shows that the radon-hazard potential of Utah is generally moderate. Assessments of hazard potential from detailed field investigations correlate well with areas of this map. Central Utah has the highest radon-hazard potential, primarily due to uranium-enriched Tertiary volcanic rocks. The radon-hazard potential of eastern Utah is moderate to high, but is generally restricted by low uranium levels. Western Utah, where valley basins with impermeable soils and shallow ground water are common, has the lowest radon-hazard potential.

  18. An intervention to reduce playground equipment hazards

    PubMed Central

    Roseveare, C.; Brown, J.; McIntosh, J.; Chalmers, D.

    1999-01-01

    Objectives—A community intervention trial was carried out to evaluate the relative effectiveness of two methods of reducing playground hazards in schools. The study hypotheses were: (1) a health promotion programme addressing barriers to implementing the New Zealand Playground Safety Standard will reduce playground hazards and (2) the intervention programme will be more successful than providing information alone. Methods—Twenty four schools in Wellington, New Zealand were randomly allocated into two groups of 12 and their playgrounds audited for hazards. After the audit, the intervention group received a health promotion programme consisting of information about the hazards, an engineer's report, regular contact and encouragement to act on the report, and assistance in obtaining funding. The control group only received information about hazards in their playground. Results—After 19 months, there was a significant fall in hazards in the intervention schools compared with the control schools (Mann-Whitney U test, p=0.027). No intervention schools had increased hazards and eight out of 12 had reduced them by at least three. In contrast, only two of the control schools had reduced their hazards by this amount, with three others increasing their hazards in that time. Conclusions—It is concluded that working intensively with schools to overcome barriers to upgrading playground equipment can lead to a reduction in hazards, and that this form of intensive intervention is more effective than providing information alone. PMID:10385832

  19. Hazards assessment for the INEL Landfill Complex

    SciTech Connect

    Knudsen, J.K.; Calley, M.B.

    1994-02-01

    This report documents the hazards assessment for the INEL Landfill Complex (LC) located at the Idaho National Engineering Laboratory, which is operated by EG&G Idaho, Inc., for the US Department of Energy (DOE). The hazards assessment was performed to ensure that this facility complies with DOE and company requirements pertaining to emergency planning and preparedness for operational emergencies. DOE Order 5500.3A requires that a facility-specific hazards assessment be performed to provide the technical basis for facility emergency planning efforts. This hazards assessment was conducted in accordance with DOE Headquarters and the DOE Idaho Operations Office (DOE-ID) guidance to comply with DOE Order 5500.3A. The hazards assessment identifies and analyzes the hazards that are significant enough to warrant consideration in a facility`s operational emergency management program. The area surrounding the LC, the buildings and structures at the LC, and the processes that are used at the LC are described in this report. All hazardous materials, both radiological and nonradiological, at the LC were identified and screened against threshold quantities according to DOE Order 5500.3A guidance. Asbestos at the Asbestos Pit was the only hazardous material that exceeded its specified threshold quantity. However, the type of asbestos received and the packaging practices used are believed to limit the potential for an airborne release of asbestos fibers. Therefore, in accordance with DOE Order 5500.3A guidance, no further hazardous material characterization or analysis was required for this hazards assessment.

  20. Hazard evaluation for 244-AR vault facility

    SciTech Connect

    BRAUN, D.J.

    1999-08-25

    This document presents the results of a hazard identification and evaluation performed on the 244-AR Vault Facility to close a USQ (USQ No.TF-98-0785, Potential Inadequacy in Authorization Basis (PIAB): To Evaluate Miscellaneous Facilities Listed In HNF-2503 And Not Addressed In The TWRS Authorization Basis) that was generated as part of an evaluation of inactive TWRS facilities. A hazard evaluation for the Hanford Site 244-AR Vault Facility was performed. The process and results of the hazard evaluation are provided in this document. A previous hazard evaluation was performed for the 244-AR Vault Facility in 1996 in support of the Basis for Interim Operation (BIO) (HNF-SD-WM-BIO-001, 1998, Revision 1) of the Tank Waste Remediation System (TWRS). The results of that evaluation are provided in the BIO. Upon review of those results it was determined that hazardous conditions that could lead to the release of radiological and toxicological material from the 244-AR vaults due to flooding was not addressed in the original hazards evaluation. This supplemental hazard evaluation addresses this oversight of the original hazard evaluation. The results of the hazard evaluation were compared to the current TWRS BIO to identify any hazardous conditions where Authorization Basis (AB) controls may not be sufficient or may not exist. This document is not part of the AB and is not a vehicle for requesting changes to the AB. It is only intended to provide information about hazardous conditions associated with the condition and configuration of the 244-AR vault facility. The AB Control Decision process could be used to determine the applicability and adequacy of existing AB controls as well as any new controls that may be needed for the identified hazardous conditions associated with 244-AR vault flooding. This hazard evaluation does not constitute an accident analysis.