Science.gov

Sample records for age national origin

  1. The origins of human ageing.

    PubMed Central

    Kirkwood, T B

    1997-01-01

    The origins of human ageing are to be found in the origins and evolution of senescence as a general feature in the life histories of higher animals. Ageing is an intriguing problem in evolutionary biology because a trait that limits the duration of life, including the fertile period, has a negative impact on Darwinian fitness. Current theory suggests that senescence occurs because the force of natural selection declines with age and because longevity is only acquired at some metabolic cost. In effect, organisms may trade late survival for enhanced reproductive investments in earlier life. The comparative study of ageing supports the general evolutionary theory and reveals that human senescence, while broadly similar to senescence in other mammalian species, has distinct features, such as menopause, that may derive from the interplay of biological and social evolution. PMID:9460059

  2. Photograph of original drawing (original in possession of National Passenger ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photograph of original drawing (original in possession of National Passenger Railroad Corporation). Canopy Plans, Sections, and Details (n.d.) - North Philadelphia Station, 2900 North Broad Street, on northwest corner of Broad Street & Glenwood Avenue, Philadelphia, Philadelphia County, PA

  3. National Council on Aging

    MedlinePlus

    ... Security Benefits for Seniors Home Equity Older Workers Money Management Healthy Aging Falls Prevention Chronic Disease Management ... tips and resources to manage your budget, save money, avoid scams, find a job, and more. Go ...

  4. Photocopy of original drawings (original located at the National Archives, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of original drawings (original located at the National Archives, San Bruno, California, Navy # 104-A-14). Dept. of yards and docks, "Chapel amplifier support," October 1945. - Mare Island Naval Shipyard, St. Peter's Chapel, Walnut Street & Cedar Parkway, Vallejo, Solano County, CA

  5. Photocopy of original drawings (original located at the National Archives, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of original drawings (original located at the National Archives, San Bruno, California, Navy # 104-A-22), showing current floor plan. Department of the Navy, Bureau of Yards and Docks, "Record drawing, N.D. - Mare Island Naval Shipyard, St. Peter's Chapel, Walnut Street & Cedar Parkway, Vallejo, Solano County, CA

  6. Photocopy of original drawings (original located at the National Archives, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of original drawings (original located at the National Archives, San Bruno, California, Navy # 104-A-25) William Jeffries Associates, A.I.A., "Repair to stained glass window, building 104, elevation & details," September 1952. - Mare Island Naval Shipyard, St. Peter's Chapel, Walnut Street & Cedar Parkway, Vallejo, Solano County, CA

  7. Photocopy of original drawings (original located at the National Archives, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of original drawings (original located at the National Archives, San Bruno, California, Navy # 104-A-5). Depts. Yards & docks, U.S. Navy Mare Island, Cal., "full sized detail of fretwork panels in back of organ recess, St. Peter's Chapel, Mare Island, Cal., December 1904. - Mare Island Naval Shipyard, St. Peter's Chapel, Walnut Street & Cedar Parkway, Vallejo, Solano County, CA

  8. Photocopy of original drawings (original located at the National Archives, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of original drawings (original located at the National Archives, San Bruno, California, Navy # 104-A-13). (Signed) Ralph Whitman, public works officer, "Yard chapel organ addition mill details, exterior window," September 1929. - Mare Island Naval Shipyard, St. Peter's Chapel, Walnut Street & Cedar Parkway, Vallejo, Solano County, CA

  9. Photocopy of original drawings (original located at the National Archives, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of original drawings (original located at the National Archives, San Bruno, California, Navy # 104-A-9). (Signed) Ralph Whitman, public works officer, "Yard chapel addition to house organ, etc., plans, elevations, details," September 1929. - Mare Island Naval Shipyard, St. Peter's Chapel, Walnut Street & Cedar Parkway, Vallejo, Solano County, CA

  10. Photocopy of original drawings (original located at the National Archives, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of original drawings (original located at the National Archives, San Bruno, California, Navy # 104-A-4, showing organ recess. Dept. yards & docks, U.S. Navy, Mare Island, Cal., "Plan & Sections, proposed addition, St. Peter's Chapel, December 1904 - Mare Island Naval Shipyard, St. Peter's Chapel, Walnut Street & Cedar Parkway, Vallejo, Solano County, CA

  11. Photocopy of original drawings (original located at the National Archives, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of original drawings (original located at the National Archives, San Bruno, California, Navy # A-21). Dept. of the Navy District Public Works Office, "additions, floor plan, elevations & details; architectural, mechanical & electrical," May 1963. - Mare Island Naval Shipyard, St. Peter's Chapel, Walnut Street & Cedar Parkway, Vallejo, Solano County, CA

  12. Photograph of original drawing (original in possession of National Passenger ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photograph of original drawing (original in possession of National Passenger Railroad Corporation). STATION BUILDING: Foundation Plan / Alterations and Additions (dated: 7/17/14) - North Philadelphia Station, 2900 North Broad Street, on northwest corner of Broad Street & Glenwood Avenue, Philadelphia, Philadelphia County, PA

  13. Photograph of original drawing (original in possession of National Passenger ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photograph of original drawing (original in possession of National Passenger Railroad Corporation). Plans, Elevations, and Details of Stair Canopies (n.d.) - North Philadelphia Station, 2900 North Broad Street, on northwest corner of Broad Street & Glenwood Avenue, Philadelphia, Philadelphia County, PA

  14. 76 FR 65203 - National Institute on Aging

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-20

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging ACTION: Notice of Closed... of Committee: National Institute on Aging Special Emphasis Panel; Mechanisms of Osteoporosis II. Date...: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  15. 29 CFR 1606.1 - Definition of national origin discrimination.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 4 2012-07-01 2012-07-01 false Definition of national origin discrimination. 1606.1... GUIDELINES ON DISCRIMINATION BECAUSE OF NATIONAL ORIGIN § 1606.1 Definition of national origin discrimination. The Commission defines national origin discrimination broadly as including, but not limited to,...

  16. 29 CFR 1606.1 - Definition of national origin discrimination.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 4 2014-07-01 2014-07-01 false Definition of national origin discrimination. 1606.1... GUIDELINES ON DISCRIMINATION BECAUSE OF NATIONAL ORIGIN § 1606.1 Definition of national origin discrimination. The Commission defines national origin discrimination broadly as including, but not limited to,...

  17. 29 CFR 1606.1 - Definition of national origin discrimination.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 4 2013-07-01 2013-07-01 false Definition of national origin discrimination. 1606.1... GUIDELINES ON DISCRIMINATION BECAUSE OF NATIONAL ORIGIN § 1606.1 Definition of national origin discrimination. The Commission defines national origin discrimination broadly as including, but not limited to,...

  18. 76 FR 21386 - National Institute on Aging

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Organelle Lifespan Mechanism II. Date: June... Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892...

  19. 27 CFR 5.56 - Certificates of age and origin.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Certificates of age and... Labels of Domestically Bottled Distilled Spirits § 5.56 Certificates of age and origin. Distilled spirits... the bottler possesses certificates of age and certificates of origin applicable to such spirits...

  20. 27 CFR 5.56 - Certificates of age and origin.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Certificates of age and... Labels of Domestically Bottled Distilled Spirits § 5.56 Certificates of age and origin. Distilled spirits... the bottler possesses certificates of age and certificates of origin applicable to such spirits...

  1. 27 CFR 5.56 - Certificates of age and origin.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Certificates of age and... Labels of Domestically Bottled Distilled Spirits § 5.56 Certificates of age and origin. Distilled spirits... the bottler possesses certificates of age and certificates of origin applicable to such spirits...

  2. 27 CFR 5.56 - Certificates of age and origin.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Certificates of age and... Labels of Domestically Bottled Distilled Spirits § 5.56 Certificates of age and origin. Distilled spirits... the bottler possesses certificates of age and certificates of origin applicable to such spirits...

  3. 27 CFR 5.56 - Certificates of age and origin.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Certificates of age and... Labels of Domestically Bottled Distilled Spirits § 5.56 Certificates of age and origin. Distilled spirits... the bottler possesses certificates of age and certificates of origin applicable to such spirits...

  4. Aging Education: A National Imperative

    ERIC Educational Resources Information Center

    McGuire, Sandra L.; Klein, Diane A.; Couper, Donna

    2005-01-01

    Americans are living longer than ever before. However, many are not prepared for the long life ahead of them. Although lifespan-aging education has been endorsed since the first White House Conference on Aging in 1961, little is happening with aging education in our homes, schools and communities. Americans often reach old age with little or no…

  5. 27 CFR 5.52 - Certificates of age and origin.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Certificates of age and... From Customs Custody of Bottled Imported Distilled Spirits § 5.52 Certificates of age and origin. (a... government must certify to the age of the youngest distilled spirits in the bottle. The age certified...

  6. 27 CFR 5.52 - Certificates of age and origin.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Certificates of age and... From Customs Custody of Bottled Imported Distilled Spirits § 5.52 Certificates of age and origin. (a... government must certify to the age of the youngest distilled spirits in the bottle. The age certified...

  7. 27 CFR 5.52 - Certificates of age and origin.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Certificates of age and... From Customs Custody of Bottled Imported Distilled Spirits § 5.52 Certificates of age and origin. (a... government must certify to the age of the youngest distilled spirits in the bottle. The age certified...

  8. 27 CFR 5.52 - Certificates of age and origin.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Certificates of age and... From Customs Custody of Bottled Imported Distilled Spirits § 5.52 Certificates of age and origin. (a... government must certify to the age of the youngest distilled spirits in the bottle. The age certified...

  9. 27 CFR 5.52 - Certificates of age and origin.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Certificates of age and... From Customs Custody of Bottled Imported Distilled Spirits § 5.52 Certificates of age and origin. (a... government must certify to the age of the youngest distilled spirits in the bottle. The age certified...

  10. 18 CFR 1300.105 - National origin harassment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false National origin... STANDARDS OF CONDUCT FOR EMPLOYEES OF TENNESSEE VALLEY AUTHORITY § 1300.105 National origin harassment. It... national origin harassment. Accordingly, all employees must avoid any action or conduct which could...

  11. 18 CFR 1300.105 - National origin harassment.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false National origin... STANDARDS OF CONDUCT FOR EMPLOYEES OF TENNESSEE VALLEY AUTHORITY § 1300.105 National origin harassment. It... national origin harassment. Accordingly, all employees must avoid any action or conduct which could...

  12. 18 CFR 1300.105 - National origin harassment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false National origin... STANDARDS OF CONDUCT FOR EMPLOYEES OF TENNESSEE VALLEY AUTHORITY § 1300.105 National origin harassment. It... national origin harassment. Accordingly, all employees must avoid any action or conduct which could...

  13. 18 CFR 1300.105 - National origin harassment.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false National origin... STANDARDS OF CONDUCT FOR EMPLOYEES OF TENNESSEE VALLEY AUTHORITY § 1300.105 National origin harassment. It... national origin harassment. Accordingly, all employees must avoid any action or conduct which could...

  14. 18 CFR 1300.105 - National origin harassment.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true National origin... STANDARDS OF CONDUCT FOR EMPLOYEES OF TENNESSEE VALLEY AUTHORITY § 1300.105 National origin harassment. It... national origin harassment. Accordingly, all employees must avoid any action or conduct which could...

  15. 29 CFR 1606.1 - Definition of national origin discrimination.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Definition of national origin discrimination. 1606.1 Section 1606.1 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION GUIDELINES ON DISCRIMINATION BECAUSE OF NATIONAL ORIGIN § 1606.1 Definition of national origin...

  16. 29 CFR 1606.1 - Definition of national origin discrimination.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 4 2011-07-01 2011-07-01 false Definition of national origin discrimination. 1606.1 Section 1606.1 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION GUIDELINES ON DISCRIMINATION BECAUSE OF NATIONAL ORIGIN § 1606.1 Definition of national origin...

  17. National Origin and Behavioural Problems of Toddlers: The Role of Family Risk Factors and Maternal Immigration Characteristics

    ERIC Educational Resources Information Center

    Jansen, Pauline W.; Raat, Hein; Mackenbach, Johan P.; Jaddoe, Vincent W. V.; Hofman, Albert; van Oort, Floor V.; Verhulst, Frank C.; Tiemeier, Henning

    2010-01-01

    In many societies the prevalence of behavioural problems in school-aged children varies by national origin. We examined the association between national origin and behavioural problems in 1 1/2-year-old children. Data on maternal national origin and the Child Behavior Checklist for toddlers (n = 4943) from a population-based cohort in the…

  18. Conforming Amendments to the Regulations Governing Nondiscrimination on the Basis of Race, Color, National, Origin, Disability, Sex, and Age under the Civil Rights Restoration Act of 1987; Final Rule. Federal Register, Part IV: Department of Education, 34 CFR Parts 100, 104, 106, and 110.

    ERIC Educational Resources Information Center

    Federal Register, 2000

    2000-01-01

    The Secretary amends the regulations governing nondiscrimination on the basis of race, color, national origin, sex, handicap, and age to conform with statutory amendments made by the Civil Rights Restoration Act of 1987 (CRRA). These amendments add a definition of "program or activity" or "program" that adopts the statutory definition of "program…

  19. 75 FR 56551 - National Institute on Aging; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-16

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Meeting Pursuant to... conducted by the National Institute on Aging, including consideration of personnel qualifications and... individual investigators. Place: National Institute on Aging, Biomedical Research Center, 251...

  20. Aging research, black Americans, and the National Institute on Aging.

    PubMed

    Cowell, D D

    1983-01-01

    The number as well as proportion of persons over the age of 65 is growing at an unprecedented rate. Elderly blacks now comprise about 8 percent of the 24 million Americans over 65. Elderly people who are also minority-group members have special needs and concerns because of the double handicap posed by ageism and racism.Since its creation by Congress in 1974, the National Institute on Aging (NIA) has taken the lead in conducting and supporting medical, social, and behavioral research related to the aging process and the special problems and needs of the aged. The author discusses black-oriented research currently supported by the NIA and the priorities which the institute has established in attempting to meet the opportunities and challenges posed by the "graying" of our nation.

  1. [Thermodynamics of the origin of life, evolution and aging].

    PubMed

    Gladyshev, G P

    2014-01-01

    Briefly discusses the history of the search of thermodynamic approach to explain the origin of life, evolution and aging of living beings. The origin of life is the result of requirement by the quasi-equilibrium hierarchical thermodynamics, in particular, the supramolecular thermodynamics. The evolution and aging of living beings is accompanied with changes of chemical and supramolecular compositions of living bodies, as well as with changes in the composition and structure of all hierarchies of the living world. The thermodynamic principle of substance stability predicts the existence of a single genetic code in our universe. The thermodynamic theory optimizes physiology and medicine and recommends antiaging diets and medicines. Hierarchical thermodynamics forms the design diversity of culture and art. The thermodynamic theory of origin of life, evolution and aging is the development of Clausius-Gibbs thermodynamics. Hierarchical thermodynamics is the mirror of Darwin-Wallace's-theory.

  2. 78 FR 46995 - National Institute on Aging; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-02

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Meeting Pursuant to... conducted by the NATIONAL INSTITUTE ON AGING, including consideration of personnel qualifications and... qualifications and performance, and competence of individual investigators. Place: National Institute on...

  3. 76 FR 57062 - National Institute on Aging; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Meeting Pursuant to... conducted by the National Institute on Aging, including consideration of personnel qualifications and... qualifications and performance, and competence of individual investigators. Place: National Institute on...

  4. Age and Origin of the Crustal Dichotomy in Eastern Mars

    NASA Technical Reports Server (NTRS)

    Frey, H. V.

    2002-01-01

    The crustal dichotomy in eastern Mars is largely due to the very large impact which produced the Utopia Basin. Buried impact basins on the Utopia Basin constrain the Utopia impact (and therefore the dichotomy) to be very Early Noachian in age. Additional information is contained in the original extended abstract.

  5. 10. Photocopy of negative (original in possession of Chiricahua National ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Photocopy of negative (original in possession of Chiricahua National Monument), photographer unknown, c.1910 JA HU STAFFORD AND YOUNGEST DAUGHTER IN FRONT OF WEST SIDE OF CABIN - Faraway Ranch, Stafford-Riggs Cabin, Willcox, Cochise County, AZ

  6. 45. Photocopy of original construction drawing by Yosemite National Park, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    45. Photocopy of original construction drawing by Yosemite National Park, California, dated August, 1931. (Original located at Federal Records Center, Denver, Colorado - 104/5069) PLAN FOR CONTROLLING LEAKAGE AT POWER HOUSE DIVERSION DAM - Yosemite Hydroelectric Power Plant, Highways 120 & 140, Yosemite Village, Mariposa County, CA

  7. 76 FR 30374 - National Institute on Aging; Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Meetings Notice of Closed... of Committee: National Institute on Aging Special Emphasis Panel; Member Conflict Sep. Date: June 2..., PhD, Chief, Scientific Review Branch, National Institute on Aging, National Institutes of...

  8. Tracing the Origins of Success: Implications for Successful Aging

    PubMed Central

    Peterson, Nora M.; Martin, Peter

    2015-01-01

    Purpose of the Study: This paper addresses the debate about the use of the term “successful aging” from a humanistic, rather than behavioral, perspective. It attempts to uncover what success, a term frequently associated with aging, is: how can it be defined and when did it first come into use? In this paper, we draw from a number of humanistic perspectives, including the historical and linguistic, in order to explore the evolution of the term “success.” We believe that words and concepts have deep implications for how concepts (such as aging) are culturally and historically perceived. Design and Methods: We take a comparative approach, turning to the etymological roots of this term in British, French, and German literature. According to the earliest entries of the term in the Oxford English Dictionary, events can have good or bad success. Another definition marks success as outcome oriented. Results: Often used in the context of war, religion, and medicine, the neutral, but often negative, use of “success” in literature of the Renaissance demonstrates the tensions that surround the word, and suggests that success is something to be approached carefully. Implications: Ignoring the ambiguous origins of success erases the fact that aging in earlier centuries echoes much of the same ambivalence with which many people discuss it today. Attending to the origins of success can help gerontologists understand the humanistic tradition behind their inquiry into what successful aging means today. PMID:24997595

  9. 75 FR 77887 - National Institute on Aging; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-14

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Meeting Pursuant to... a meeting of the National Advisory Council on Aging. The meeting will be open to the public as... privacy. Name of Committee: National Advisory Council on Aging. Date: January 25-26, 2011. Closed:...

  10. 77 FR 24727 - National Institute on Aging; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-25

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Meeting Pursuant to... a meeting of the National Advisory Council on Aging. The meeting will be open to the public as... privacy. Name of Committee: National Advisory Council on Aging. Date: May 22-23, 2012. Closed: May...

  11. 75 FR 18511 - National Institute on Aging; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-12

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Meeting Pursuant to... a meeting of the National Advisory Council on Aging. The meeting will be open to the public as... privacy. Name of Committee: National Advisory Council on Aging. Date: May 25-26, 2010. Closed: May...

  12. 78 FR 50068 - National Institute on Aging; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Meeting Pursuant to... a meeting of the National Advisory Council on Aging. The meeting will be open to the public as... privacy. Name of Committee: National Advisory Council on Aging. Date: September 17-18, 2013....

  13. 77 FR 50704 - National Institute on Aging; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-22

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Meeting Pursuant to... a meeting of the National Advisory Council on Aging. The meeting will be open to the public as... privacy. Name of Committee: National Advisory Council on Aging. Date: September 18-19, 2012....

  14. 75 FR 49499 - National Institute on Aging; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-13

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Meeting Pursuant to... a meeting of the National Advisory Council on Aging. The meeting will be open to the public as... Committee: National Advisory Council on Aging. Date: September 21-22, 2010. Closed: September 21, 2010, 3...

  15. 77 FR 76054 - National Institute on Aging; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Meeting Pursuant to... a meeting of the National Advisory Council on Aging. The meeting will be open to the public as... privacy. Name of Committee: National Advisory Council on Aging. Date: January 29-30, 2013. Closed:...

  16. 78 FR 24224 - National Institute on Aging; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-24

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Meeting Pursuant to... a meeting of the National Advisory Council on Aging. The meeting will be open to the public as... privacy. Name of Committee: National Advisory Council on Aging. Date: June 4-5, 2013. Closed: June 4,...

  17. Down Syndrome: Parental Origin, Recombination, and Maternal Age

    PubMed Central

    Vraneković, Jadranka; Božović, Ivana Babić; Grubić, Zorana; Wagner, Jasenka; Pavlinić, Dinko; Dahoun, Sophie; Bena, Frédérique; Čulić, Vida

    2012-01-01

    The aims of the present study were to assess (1) the parental origin of trisomy 21 and the stage in which nondisjunction occurs and (2) the relationship between altered genetic recombination and maternal age as risk factors for trisomy 21. The study included 102 cases with Down syndrome from the Croatian population. Genotyping analyses were performed by polymerase chain reaction using 11 short tandem repeat markers along chromosome 21q. The vast majority of trisomy 21 was of maternal origin (93%), followed by paternal (5%) and mitotic origin (2%). The frequencies of maternal meiotic I (MI) and meiotic II errors were 86% and 14%, respectively. The highest proportion of cases with zero recombination was observed among those with maternal MI derived trisomy 21. A higher proportion of telomeric exchanges were presented in cases with maternal MI errors and cases with young mothers, although these findings were not statistically significant. The present study is the first report examining parental origin and altered genetic recombination as a risk factor for trisomy 21 in a Croatian population. The results support that trisomy 21 has a universal genetic etiology across different human populations. PMID:21861707

  18. Down syndrome: parental origin, recombination, and maternal age.

    PubMed

    Vraneković, Jadranka; Božović, Ivana Babić; Grubić, Zorana; Wagner, Jasenka; Pavlinić, Dinko; Dahoun, Sophie; Bena, Frédérique; Culić, Vida; Brajenović-Milić, Bojana

    2012-01-01

    The aims of the present study were to assess (1) the parental origin of trisomy 21 and the stage in which nondisjunction occurs and (2) the relationship between altered genetic recombination and maternal age as risk factors for trisomy 21. The study included 102 cases with Down syndrome from the Croatian population. Genotyping analyses were performed by polymerase chain reaction using 11 short tandem repeat markers along chromosome 21q. The vast majority of trisomy 21 was of maternal origin (93%), followed by paternal (5%) and mitotic origin (2%). The frequencies of maternal meiotic I (MI) and meiotic II errors were 86% and 14%, respectively. The highest proportion of cases with zero recombination was observed among those with maternal MI derived trisomy 21. A higher proportion of telomeric exchanges were presented in cases with maternal MI errors and cases with young mothers, although these findings were not statistically significant. The present study is the first report examining parental origin and altered genetic recombination as a risk factor for trisomy 21 in a Croatian population. The results support that trisomy 21 has a universal genetic etiology across different human populations. PMID:21861707

  19. 2. Photocopy of photograph (original print located at Prescott National ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Photocopy of photograph (original print located at Prescott National Forest, 344 South Cortez Street, Prescott, Arizona). Photograph is an enlargement of the negative. Photographer unknown, 1926 'TONTO RANGER STATION PRESCOTT N.F. 1926.' VIEW LOOKING SOUTH. FROM LEFT TO RIGHT: HOUSE, WINDMILL, WATER STORAGE TANK, GARAGE, BARN. - Tonto Ranger Station, Forest Service Road 65 at Tonto Wash, Skull Valley, Yavapai County, AZ

  20. 1. Photocopy of photograph (original print located at Prescott National ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Photocopy of photograph (original print located at Prescott National Forest, 344 South Cortez Street, Prescott, Arizona). Photograph is an enlargement of the negative. Photographer unknown, 1946 'TONTO SPRINGS CABIN PRESCOTT N.F. - 1946.' VIEW LOOKING NORTH. - Tonto Ranger Station, Forest Service Road 65 at Tonto Wash, Skull Valley, Yavapai County, AZ

  1. Photocopy of photograph (original photograph located in the National Park ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of photograph (original photograph located in the National Park Service, U.S.S. Arizona Memorial, 14th Naval District Photograph Collection), 14th ND PHOG No. 15233. U.S. Navy photograph, 1942. VIEW SHOWS CONSTRUCTION OF DRYDOCK NO. 3 (FACILITY S781). - U.S. Naval Base, Pearl Harbor, Waterfront Facilities, Various locations throughout base, Pearl City, Honolulu County, HI

  2. 26. Photocopy of photograph (original owned by John Brinckmann, National ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    26. Photocopy of photograph (original owned by John Brinckmann, National Railway Historical Society, 17 Runyon Avenue, Edison, New Jersey), date unknown (circa 1930), photographer unknown. PERMIT 192 - BUS 161, FOR ROUTE 42 (CLAYTON), VIEW NORTH FROM MT. EPHRAIM AVENUE, BUILDING I IN BACKGROUND - Public Service Railway Company, Newton Avenue Car Shops, Bounded by Tenth, Mount Ephraim, Border & Newton Avenue, Camden, Camden County, NJ

  3. 25. Photocopy of photograph (original owned by John Brinckmann, National ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    25. Photocopy of photograph (original owned by John Brinckmann, National Railway Historical Society, 17 Runyon Avenue, Edison, New Jersey), dated April 6, 1929, photographer unknown. VIEW SOUTHWEST DOWN NEWTON AVENUE, BUILDINGS J AND K AT LEFT - Public Service Railway Company, Newton Avenue Car Shops, Bounded by Tenth, Mount Ephraim, Border & Newton Avenue, Camden, Camden County, NJ

  4. 24. Photocopy of photograph (original owned by John Brinckmann, National ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    24. Photocopy of photograph (original owned by John Brinckmann, National Railway Historical Society, 17 Runyon Avenue, Edison, New Jersey), dated September 1924, photographer unknown. VIEW EAST ACROSS FACILITY, BUILDINGS J, K AND I TO LEFT, H AND G TO RIGHT - Public Service Railway Company, Newton Avenue Car Shops, Bounded by Tenth, Mount Ephraim, Border & Newton Avenue, Camden, Camden County, NJ

  5. Photocopy of drawing (original located at the National Archives, San ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing (original located at the National Archives, San Bruno, California, Navy # A1-3). Ordnance Dept. of Navy Yard Mare Island "Magazine no. 1 - general plan of proposal. September, 1901 - Mare Island Naval Shipyard, Magazine No. 1, Railroad Avenue, west side near Maseda Road, Vallejo, Solano County, CA

  6. 76 FR 20360 - National Institute on Aging; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Meeting Pursuant to... a meeting of the National Advisory Council on Aging. The meeting will be open to the public as... on Aging. Date: May 24-25, 2011. Closed: May 24, 2011, 3 p.m. to 5 p.m. Agenda: To review...

  7. 76 FR 78285 - National Institute on Aging; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-16

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Meeting Pursuant to... a meeting of the National Advisory Council on Aging. The meeting will be open to the public as... on Aging. Date: January 24-25, 2012. ] Closed: January 24, 2012, 3 p.m. to 5 p.m. Agenda: To...

  8. 76 FR 46823 - National Institute on Aging; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-03

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Meeting Pursuant to... a meeting of the National Advisory Council on Aging. The meeting will be open to the public as... on Aging. Date: September 20-21, 2011. Closed: September 20, 2011, 3 p.m. to 5 p.m. Agenda: To...

  9. 78 FR 16858 - National Institute on Aging; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-19

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Meeting Pursuant to... conducted by the National Institute on Aging, including consideration of personnel qualifications and... Institute on Aging, Biomedical Research Center, 251 Bayview Blvd., 3rd Floor, Conference Room...

  10. 75 FR 17149 - National Institute on Aging; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-05

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Meeting Pursuant to... conducted by the National Institute on Aging, including consideration of personnel qualifications and... Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, 3rd Floor Conference Room,...

  11. 77 FR 55849 - National Institute on Aging; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-11

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Meeting Pursuant to... conducted by the National Institute on Aging, including consideration of personnel qualifications and... Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, 3rd Floor Conference Room,...

  12. 77 FR 19675 - National Institute on Aging; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-02

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Meeting Pursuant to... conducted by the National Institute on Aging, including consideration of personnel qualifications and... Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, 3rd Floor Conference Room,...

  13. 76 FR 27336 - National Institute on Aging; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Meeting Pursuant to... conducted by the National Institute on Aging, including consideration of personnel qualifications and... Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, 3rd Floor Conference Room,...

  14. Photocopy of photograph (original photograph located in the National Park ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of photograph (original photograph located in the National Park Service, U.S.S. Arizona Memorial, 14th Naval District Photograph Collection), 14th ND C.W. No. P88-7864. U.S. Navy photograph, September 1933. VIEW OF THE MAIN SHIPYARD BERTHING. BY THIS DATE THE ORIGINAL 1010 DOCK (FACILITY B2) HAD BEEN EXTENDED AT EITHER END (FACILITIES B1 AND B3). THE SMALL BOAT LANDING (FACILITY N2) IS IN THE FOREGROUND. - U.S. Naval Base, Pearl Harbor, Waterfront Facilities, Various locations throughout base, Pearl City, Honolulu County, HI

  15. Photocopy of photograph (original photograph located in National Park Service, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of photograph (original photograph located in National Park Service, U.S.S. Arizona Memorial, 14th Naval District Photograph Collection), 14th ND PHOG No. N.H. 82807. U.S. Navy photograph, September 1942. FACILITY 250 UNDER CONSTRUCTION, BEFORE TWO ADDITIONAL WOOD-FRAMED STORIES WERE ADDED TO THE ROOF. - U.S. Naval Base, Pearl Harbor, Headquarters, Commander-in-Chief of the Pacific Fleet, Intersection of Halawa & Makalapa Drives, Makalapa Administration Area, Pearl City, Honolulu County, HI

  16. Photocopy of photograph (original photograph located in the National Park ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of photograph (original photograph located in the National Park Service, U.S.S. Arizona Memorial, 14th Naval District Photograph Collection), 14th ND PHOG No. P.H. 4175-42. U.S. Navy photograph, 1942. THE NAVAL SUPPLY DEPOT’S HUGE FUELING PIER (FACILITY H1-H4) HELPED KEEP THE FLEET MOVING DURING WORLD WAR II. - U.S. Naval Base, Pearl Harbor, Waterfront Facilities, Various locations throughout base, Pearl City, Honolulu County, HI

  17. Photocopy of photograph (original photograph located in National Park Service, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of photograph (original photograph located in National Park Service, U.S.S. Arizona Memorial, 14th Naval District Photograph Collection), PHOG No. P.H. 3309-42. U.S. Navy photograph, 1942. BEGINNING CONSTRUCTION ON THE BOMBPROOF POWER PLANT (FACILITY 177) AT HOSPITAL POINT. - U.S. Naval Base, Pearl Harbor, Bombproof Facilities, Various locations throughout base, Pearl City, Honolulu County, HI

  18. Photocopy of photograph (original photograph located in the National Park ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of photograph (original photograph located in the National Park Service, U.S.S. Arizona Memorial, 14th Naval District Photograph Collection), 14th ND Temp. No. 890. U.S. Navy photograph, circa 1935. CONSTRUCTION OF THE REPAIR BASIN (FACILITIES B12 THROUGH B21) PROCEEDED QUICKLY AS DID THE ERECTION OF THE 200-TON HAMMERHEAD CRANE (BASE VISIBLE ON LEFT). - U.S. Naval Base, Pearl Harbor, Waterfront Facilities, Various locations throughout base, Pearl City, Honolulu County, HI

  19. Photocopy of photograph (original photograph located in the National Park ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of photograph (original photograph located in the National Park Service, U.S.S. Arizona Memorial, 14th Naval District Photograph Collection), 14th ND Temp. No. 722. U.S. Navy photograph, early 1930s. BERTHING AT THE SUBMARINE BASE INCLUDED THE FOUR PIERS (NOW GONE) AND SOME OF THE QUAYWALL (FACILITIES S10 TO S12) ALONG MAGAZINE LOCK. - U.S. Naval Base, Pearl Harbor, Waterfront Facilities, Various locations throughout base, Pearl City, Honolulu County, HI

  20. Photocopy of photograph (original photograph located in the National Park ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of photograph (original photograph located in the National Park Service, U.S.S. Arizona Memorial, 14th Naval District Photograph Collection), 14th ND PHOG No. 2984. U.S. Navy photograph, August 1919. VIEW OF COALING STATION FROM RADIO TOWER NO. 1. REMNANTS OF THE COAL STATION WALLS AND PIER (FACILITY O1) REMAIN. - U.S. Naval Base, Pearl Harbor, Waterfront Facilities, Various locations throughout base, Pearl City, Honolulu County, HI

  1. Photocopy of photograph (original photograph located in National Park Service, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of photograph (original photograph located in National Park Service, U.S.S. Arizona Memorial, 14th Naval District Photograph Collection), PHOG No. P.H. 3470-42. U.S. Navy photograph, August 1942. INTERIOR VIEW OF THE HOSPITAL POINT POWER PLANT (FACILITY 177). - U.S. Naval Base, Pearl Harbor, Bombproof Facilities, Various locations throughout base, Pearl City, Honolulu County, HI

  2. Photocopy of photograph (original photograph located in National Park Service, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of photograph (original photograph located in National Park Service, U.S.S. Arizona Memorial, 14th Naval District Photograph Collection), 14th ND PHOG no. PH 00-46. U.S. Navy photograph, 1946. FACILITY 250 AT MAKALAPA WITH ADDED WOOD-FRAMED STORIES. - U.S. Naval Base, Pearl Harbor, Headquarters, Commander-in-Chief of the Pacific Fleet, Intersection of Halawa & Makalapa Drives, Makalapa Administration Area, Pearl City, Honolulu County, HI

  3. Origin and Age of the Yemi Limestone Breccia, Korea

    NASA Astrophysics Data System (ADS)

    KOH, Hee Jae

    2015-04-01

    The Yemi Limestone Breccia (YLB), which has been argued for its age and depositional origin, occurs sporadically in the upper part of the Cambro-Ordovician Chosun Supergroup (CS) in Korean Peninsula. The YLB is characterized by a carbonate breccia with calcareous and carbonaceous shale matrix. Based on occurrence and composition of breccia and matrix, the YLB can be classified into Type-I and Type-II carbonate breccia. Type-I carbonate breccia comprises dark gray to light gray limestone and lime-mudstone breccia with calcareous matrix and is commonly constrained within the upper part of the CS as a lens-shaped zonal occurrence. The Type-I carbonate breccia results in syn-depositional solution-collapsed brecciation through karstification during intermittent subareal exposure of platform carbonate in Middle Ordovician. Type-II carbonate breccia mainly occurs in the uppermost part of the CS showing an irregular-shaped distribution rather than sheet-like layering parallel to bedding. Type-II carbonate breccia consists of gray to dark gray limestone and lime-mudstone breccia and shale matrix. Matrix is typically purple to reddish and gray to dark gray shale with minor amount of sandstone, and partly carbonaceous indicating organic origin. Most of Type-II carbonate breccia is morphologically classified into chaotic breccia. Matrix and breccia display considerable difference of composition and deformational structures. Breccia preserves various penetrative ductile to brittle deformation structures such as cleavage superimposing bedding, minor fold structure, minor faults crosscutting both dolomite and calcite veins, and fracture zones filled in calcite. However, these deformational structures of breccia do not continuously extended into matrix. Especially Type-II carbonate breccia is well observed in limestone of the lower part of unconformity between CS and clastic rocks of the Jurassic Bansong Group (BS). Fractured and solution zones of brecciated limestone of the CS

  4. 78 FR 69432 - National Institute on Aging; Cancellation of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ... November 8, 2013, 67177 FR 217. The meeting was entitled Member Conflict. Dated: November 13, 2013. Melanie... HUMAN SERVICES National Institutes of Health National Institute on Aging; Cancellation of Meeting Notice is hereby given of the cancellation of the National Institute on Aging Special Emphasis...

  5. 77 FR 40368 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-09

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel Age, Gene/Environment Susceptibility... evaluate contract proposals. Place: National Institute on Aging, Gateway Building, 7201 Wisconsin...

  6. 76 FR 69328 - Proposed Collection; Comment Request; Race and National Origin Identification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-08

    ... Proposed Collection; Comment Request; Race and National Origin Identification AGENCY: Department of The.... Type of Review: Revision of a currently approved collection. Title: Race and National Origin... and national origin information electronically from an applicant. The data will be used to...

  7. 76 FR 8961 - Rules on Source, Origin and Nationality for Commodities and Services Financed by USAID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-16

    ... DEVELOPMENT 22 CFR Part 228 RIN 0412-AA70 Rules on Source, Origin and Nationality for Commodities and Services... changes are needed to USAID's rules on Source, Origin, and Nationality (S/O/N). This solicitation is in... 228.03 and the related concepts of ``source,'' ``origin'' and ``nationality'' as defined or...

  8. Tungsten isotopic constraints on the age and origin of chondrules

    PubMed Central

    Kleine, Thorsten; Kruijer, Thomas S.; Burkhardt, Christoph; Metzler, Knut

    2016-01-01

    Chondrules may have played a critical role in the earliest stages of planet formation by mediating the accumulation of dust into planetesimals. However, the origin of chondrules and their significance for planetesimal accretion remain enigmatic. Here, we show that chondrules and matrix in the carbonaceous chondrite Allende have complementary 183W anomalies resulting from the uneven distribution of presolar, stellar-derived dust. These data refute an origin of chondrules in protoplanetary collisions and, instead, indicate that chondrules and matrix formed together from a common reservoir of solar nebula dust. Because bulk Allende exhibits no 183W anomaly, chondrules and matrix must have accreted rapidly to their parent body, implying that the majority of chondrules from a given chondrite group formed in a narrow time interval. Based on Hf-W chronometry on Allende chondrules and matrix, this event occurred ∼2 million years after formation of the first solids, about coeval to chondrule formation in ordinary chondrites. PMID:26929340

  9. 77 FR 2737 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-19

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Development and Maintenance of a... and evaluate contract proposals. Place: National Institute on Aging, Gateway Building, 7201...

  10. 75 FR 4829 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-29

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Development and Maintenance of a... contract proposals. Place: National Institute on Aging, Gateway Building, 7201 Wisconsin Ave, Suite...

  11. Aging, Research on Aging, and National Policy: A Conversation with Robert Butler.

    ERIC Educational Resources Information Center

    VandenBos, Gary R.; Buchanan, Joan

    1983-01-01

    The former director of the National Institute on Aging (NIA) discusses: consequences of aging in relation to Federal policies; care facilities for older persons; the role of the Federal government in funding aging research; and the need for more personnel trained to deal with problems of the elderly. (AOS)

  12. 48 CFR 725.704 - Source, origin and nationality requirements-Contract clause.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Source, origin and... AGENCY FOR INTERNATIONAL DEVELOPMENT SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Source, Origin, and Nationality 725.704 Source, origin and nationality requirements—Contract clause. The clause in 752.225-70...

  13. 48 CFR 725.704 - Source, origin and nationality requirements-Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Source, origin and... AGENCY FOR INTERNATIONAL DEVELOPMENT SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Source, Origin, and Nationality 725.704 Source, origin and nationality requirements—Contract clause. The clause in 752.225-70...

  14. 48 CFR 725.704 - Source, origin and nationality requirements-Contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Source, origin and... AGENCY FOR INTERNATIONAL DEVELOPMENT SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Source, Origin, and Nationality 725.704 Source, origin and nationality requirements—Contract clause. The clause in 752.225-70...

  15. 48 CFR 725.704 - Source, origin and nationality requirements-Contract clause.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Source, origin and... AGENCY FOR INTERNATIONAL DEVELOPMENT SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Source, Origin, and Nationality 725.704 Source, origin and nationality requirements—Contract clause. The clause in 752.225-70...

  16. 48 CFR 725.704 - Source, origin and nationality requirements-Contract clause.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Source, origin and... AGENCY FOR INTERNATIONAL DEVELOPMENT SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Source, Origin, and Nationality 725.704 Source, origin and nationality requirements—Contract clause. The clause in 752.225-70...

  17. 77 FR 61613 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-10

    ... Committee: National Institute on Aging Special Emphasis Panel; Systems Biology of the Aged in Yeast. Date...: National Institute on Aging Special Emphasis Panel; ROS and Aging II. Date: November 7, 2012. Time: 12:30...

  18. 77 FR 24969 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-26

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Initial Review Group; Behavior and Social Science of Aging Review.... Johnson, Ph.D., Scientific Review Officer, National Institutes on Aging, National Institutes of...

  19. 76 FR 24901 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-03

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Initial Review Group, Behavior and Social Science of Aging Review...: Jeannette L. Johnson, PhD, Scientific Review Officer, National Institute on Aging, National Institutes...

  20. 77 FR 6129 - National Institute on Aging Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-07

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging Notice of Closed Meetings... Committee: National Institute on Aging Initial Review Group; Behavior and Social Science of Aging Review...: Jeannette L. Johnson, Ph.D., Scientific Review Officer, National Institutes on Aging, National Institutes...

  1. 75 FR 56119 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-15

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Initial Review Group; Behavior and Social Science of Aging Review...: Jeannette L. Johnson, PhD, Scientific Review Officer, National Institutes on Aging, National Institutes...

  2. 77 FR 53207 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-31

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Initial Review Group, Behavior and Social Science of Aging Review...: Jeannette L. Johnson, Ph.D., Scientific Review Officer, National Institutes on Aging, National Institutes...

  3. Cosmic Ray Exposure Ages, Ar-Ar Ages, and the Origin and History of Eucrites

    NASA Technical Reports Server (NTRS)

    Wakefield, Kelli; Bogard, Donald; Garrison, Daniel

    2004-01-01

    HED meteorites likely formed at different depths on the large asteroid 4-Vesta, but passed through Vesta-derived, km-sized intermediary bodies (Vestoids), before arriving at Earth. Most eucrites and diogenites (and all howardites) are brecciated, and impact heating disturbed or reset the K-Ar ages (and some Rb-Sr ages) of most eucrites in the time period of approx. 3.4 - 4.1 Gyr ago. Some basaltic eucrites and most cumulate eucrites, however, are not brecciated. We recently showed that the Ar-39 - Ar-40 ages for several of these eucrites tightly cluster about a value of 4.48 +/- 0.02 Gyr, and we argue that this time likely represents a single large impact event on Vesta, which ejected these objects from depth and quenched their temperatures. A different parent body has been suggested for cumulate eucrites, although the Ar-Ar ages argue for a common parent. Similarities in the cosmic-ray (space) exposure ages for basaltic eucrites and diogenites also have been used to infer a common parent body for some HEDs. Here we present CRE ages of several cumulate and unbrecciated basaltic (UB) eucrites and compare these with CRE ages of other HEDs. This comparison also has some interesting implications for the relative locations of various HED types on Vesta and/or the Vestoids.

  4. 75 FR 63497 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-15

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Genetic Determinants of Healthy Aging. Date...: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  5. 77 FR 34394 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Healthy Aging and the Life Course. Date: June...: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  6. 75 FR 39698 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-12

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel, Network Infrastructure for Aging Research...: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  7. 76 FR 3148 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-19

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Initial Review Group; Biological Aging Review Committee. Date...: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  8. 78 FR 20669 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Management of the Primate Aging Database Date...: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  9. 76 FR 6628 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-07

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Initial Review Group; Behavior and Social Science of Aging Review... Person: Jeannette L. Johnson, PhD, Scientific Review Officer, National Institutes On Aging,...

  10. 75 FR 79386 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Hormone Therapy and Cognitive Aging. Date...: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  11. 76 FR 24890 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-03

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Initial Review Group, Biological Aging Review Committee. Date: June 1..., PhD, Scientific Review Officer, Scientific Review Branch, National Institute on Aging, Gateway...

  12. 78 FR 55752 - National Institute On Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-11

    ... HUMAN SERVICES National Institutes of Health National Institute On Aging; Notice of Closed Meeting... Committee: National Institute on Aging Initial Review Group, Behavior and Social Science of Aging Review...: Rebecca J. Ferrell, Ph.D., Scientific Review Officer, National Institute on Aging, Gateway Building,...

  13. 78 FR 51195 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-20

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Initial Review Group; Biological Aging Review Committee Date: October... Nakhai, Ph.D., Scientific Review Branch, National Institute On Aging, Gateway Bldg., 2C212,...

  14. Prediction of Elderly Anthropometric Dimension Based On Age, Gender, Origin, and Body Mass Index

    NASA Astrophysics Data System (ADS)

    Indah, P.; Sari, A. D.; Suryoputro, M. R.; Purnomo, H.

    2016-01-01

    Introduction: Studies have indicated that elderly anthropometric dimensions will different for each person. To determine whether there are differences in the anthropometric data of Javanese elderly, this study will analyze whether the variables of age, gender, origin, and body mass index (BMI) have been associated with elderly anthropometric dimensions. Age will be divided into elderly and old categories, gender will divide into male and female, origins were divided into Yogyakarta and Central Java, and for BMI only use the normal category. Method: Anthropometric studies were carried out on 45 elderly subjects in Sleman,Yogyakarta. Results and Discussion: The results showed that some elderly anthropometric dimensions were influenced by age, origin, and body mass index but gender doesn't significantly affect the elderly anthropometric dimensions that exist in the area of Sleman. The analysis has provided important aid when designing products that intended to the Javanese elderly Population.

  15. 75 FR 35821 - National Institute On Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-23

    ... HUMAN SERVICES National Institutes of Health National Institute On Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel Member Conflict SEP, Date: June 24, 2010. Time...: Ramesh Vemuri, PhD, Chief, Scientific Review Branch, National Institute on Aging, National Institutes...

  16. 76 FR 6628 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-07

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Sex Differences in Health and Survival. Date..., Scientific Review Officer, National Institutes on Aging, National Institutes of Health, 7201 Wisconsin...

  17. 75 FR 57965 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-23

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel, Member Conflict SEP. Date: October 4, 2010... Review Branch, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue,...

  18. 78 FR 27977 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-13

    ... Committee: National Institute on Aging Initial Review Group; Behavior and Social Science of Aging Review... Federal Domestic Assistance Program Nos. 93.866, Aging Research, National Institutes of Health, HHS)...

  19. Land Application of Wastewater Sludges: A National Science Foundation Student-Originated Studies Project.

    ERIC Educational Resources Information Center

    Bender, Timothy J.; Barnard, Walther M.

    1981-01-01

    Summarizes a student-originated studies project, funded by the National Science Foundation, on land application of wastewater sludges. Describes the students' proposal, research methods, and evaluation of the project. (DS)

  20. Arrogant Assimilationism: National Identity Politics and African-Origin Muslim Girls in the Other France

    ERIC Educational Resources Information Center

    Keaton, Trica

    2005-01-01

    National identity politics in France have taken an interesting turn since the 1980s, a period accentuated by social movements led by youth of immigration who self-asserted in terms of ethnonational origins. Now French-born or -raised youth, stigmatized by those origins, self-identify as French, although they are not so perceived in French society.…

  1. Rural origin, age, and endoparasite fecal prevalence in dogs surrendered to the Regina Humane Society, 2013

    PubMed Central

    Schurer, Janna M.; Hamblin, Brie; Davenport, Laura; Wagner, Brent; Jenkins, Emily J.

    2014-01-01

    We report the results of fecal parasite surveillance in dogs surrendered to the Regina Humane Society, Saskatchewan, Canada, between May and November 2013. Overall, 23% of 231 dogs were infected with at least 1 intestinal parasite. Endoparasite infection was positively associated with rural origin (P = 0.002) and age (< 12 months; P < 0.001). PMID:25477549

  2. Social Origin and Graduation Age: A Cohort Comparison of Danish University Students

    ERIC Educational Resources Information Center

    Klausen, Trond Beldo

    2016-01-01

    This paper investigates whether social origin has an impact on graduation age among university students. A large number of social background factors are applied on a large data set of 4 successive cohorts of Danish university graduates born 1960-1975. These are cohorts for whom university attendance increased steeply. Contrary to recent findings…

  3. The origins and early history of the National Chiropractic Association

    PubMed Central

    Keating, Joseph C; Rehm, William S

    1993-01-01

    Early organization in chiropractic was prompted by the profession’s need to promote itself and to defend against the onslaught of political medicine and organized osteopathy. The first priorities were legal defense against prosecution for unlicensed practice and malpractice insurance. The Universal Chiropractors’ Association (UCA), organized at the Palmer School of Chiropractic (PSC) in 1906, sought to meet these needs by insuring its members and by developing a legal department under the supervision of attorney Tom Morris, one time lieutenant governor of Wisconsin. The public relations and marketing needs of chiropractors were largely served by the PSC and its legendary leader. However, as chiropractors increasingly sought to avoid prosecution by passage of chiropractic laws, Palmer’s efforts to direct this legislation so as to limit chiropractors’ scope of practice increasingly alienated many in the profession. The American Chiropractic Association (ACA) was founded in 1922 to provide a broadscope alternative to BJ’s UCA. With Palmer’s departure from the UCA following the neurocalometer debacle, ACA and UCA sought amalgamation. Simultaneously, organized medicine renewed its attack on the profession by introducing basic science legislation, which prompted chiropractors to try to upgrade and standardize chiropractic education. Early efforts to bring about the needed consensus were centered in the International Chiropractic Congress (ICC), particularly its division of state examining boards. In 1930 the ACA and UCA combined to form the National Chiropractic Association (NCA), and by 1934 the ICC had merged with the NCA to form part of its council structure. With this modicum of solidarity the NCA began the process of educational boot-strapping at its 1935 convention in Los Angeles, when its Committee on Education, a forerunner of today’s Council on Chiropractic Education, was proposed by C.O. Watkins of Montana. ImagesFigure 2Figure 3Figure 4Figure 5

  4. 75 FR 26268 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-11

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel, ARRA--Behavioral Economics C.E.R.--Clinical.... Place: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C218, Bethesda,...

  5. 78 FR 51196 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-20

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Juvenile Protective Factors I. Date...: National Institute on Aging, Gateway Building, Suite 2C212, 7201 Wisconsin Avenue, Bethesda, MD...

  6. 77 FR 1941 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-12

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; GEMSSTAR. Date: January 27, 2012. Time: 8 a.m...., Scientific Review Officer, National Institute on Aging, Gateway Building, Rm. 2C212, 7201 Wisconsin...

  7. 77 FR 53207 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-31

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel, Pepper Centers. Date: September 27-28, 2012... Branch, National Institute on Aging, 7201 Wisconsin Avenue, Suite 2c212, Bethesda, MD 20892,...

  8. 75 FR 25273 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-07

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel, Basis of Myocardial Injury in the Elderly...: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  9. 77 FR 34396 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Changing Long Term Care in America. Date...: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  10. 76 FR 5391 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-31

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Pepper Centers. Date: February 17-18, 2011..., Scientific Review Branch, National Institute on Aging, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD...

  11. 75 FR 11188 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Beeson Meeting. Date: April 28-29, 2010. Time..., Scientific Review Officer, National Institute on Aging, Scientific Review Branch, Gateway Building...

  12. 77 FR 31032 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Network Infrastructure Support. Date: June 7...., Scientific Review Officer, Scientific Review Branch, National Institute on Aging, Gateway Bldg., 2C212,...

  13. 76 FR 42719 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-19

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel, The NIA Health and Retirement Study. Date.... Place: National Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda,...

  14. 76 FR 57064 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel, AD Genetics Warehouse. Date: October 7, 2011..., Scientific Review Officer, National Institute on Aging, Scientific Review Branch, Gateway Building...

  15. 76 FR 57064 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Initial Review Group, Clinical Aging Review Committee. Date: October... Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892. Contact...

  16. 77 FR 40370 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-09

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel, Aging and Innovation. Date: July 11, 2012... Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892, (Telephone...

  17. 77 FR 63843 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-17

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Aging and Sleep. Date: November 8, 2012. Time... on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892,...

  18. 75 FR 67381 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-02

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel HIV, HAART and AGING. Date: November 23, 2010... Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892, (Telephone...

  19. 76 FR 32977 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-07

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel, Aging and Economics. Date: June 24, 2011... Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892 (Telephone...

  20. 78 FR 52552 - National Institute on Aging Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-23

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging Notice of Closed Meeting... Committee: National Institute on Aging Initial Review Group, Neuroscience of Aging Review Committee. Date..., johnsonj9@nia.nih.gov . (Catalogue of Federal Domestic Assistance Program Nos. 93.866, Aging...

  1. 34 CFR 270.6 - What limitation is imposed on providing race and national origin desegregation assistance under...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... national origin desegregation assistance under these programs? 270.6 Section 270.6 Education Regulations of... national origin desegregation assistance under these programs? (a) Except as provided in paragraph (b) of this section, a recipient of a grant for race or national origin desegregation assistance under...

  2. 34 CFR 270.6 - What limitation is imposed on providing race and national origin desegregation assistance under...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... national origin desegregation assistance under these programs? 270.6 Section 270.6 Education Regulations of... national origin desegregation assistance under these programs? (a) Except as provided in paragraph (b) of this section, a recipient of a grant for race or national origin desegregation assistance under...

  3. 34 CFR 270.6 - What limitation is imposed on providing race and national origin desegregation assistance under...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... national origin desegregation assistance under these programs? 270.6 Section 270.6 Education Regulations of... national origin desegregation assistance under these programs? (a) Except as provided in paragraph (b) of this section, a recipient of a grant for race or national origin desegregation assistance under...

  4. Gender, age, and ethnicity in immigration for an Australian nation.

    PubMed

    Fincher, R

    1997-02-01

    An analysis of Australian immigration policy since the Second World War is presented. The emphasis is on the gender and age of preferred immigrants, rather than on their race or place of birth. "The author proposes that selection of immigrant settlers in Australia since World War 2 has been gendered as well as racialised, often combining particular sexisms with particular racisms and specifying the ways that ethnicity and gender should coexist in immigrants of different age groups. She notes implications for immigrants once in Australia (especially women) of the category under which they have entered the country. And she suggests that a new phase relating immigration to redefinition of the Australian nation, in which the temporary migration of skilled workers is preferred to their permanent migration, may be beginning; a phase whose modes of regulation and outcomes are as distinctively gendered as were those of their predecessors."

  5. Parental age and the origin of trisomy 21. A study of 302 families.

    PubMed

    Dagna Bricarelli, F; Pierluigi, M; Landucci, M; Arslanian, A; Coviello, D A; Ferro, M A; Strigini, P

    1989-04-01

    Several studies have attempted to define the role of parental age in determining the prevalence of 47, +21 according to the origin of nondisjunction. This report analyzes the original data of 197 informative families from Italy and reviews the available literature (96 families from Denmark and 201 from other countries). Mothers whose gametes showed nondisjunction are treated as cases, and those with normal meiosis as controls within each study. To utilize the data fully, maternal age at birth of a 47, +21 individual is treated as a continuous variable in a nonparametric comparison. The combined evidence indicates that nondisjunction in the female is associated with a significant age difference between cases and controls which is mostly due to errors in the second meiotic division. It may be inferred that in the general population, aging enhances nondisjunction at both first and second division in the female, while aging in the male is presumably associated mostly (or only) with first division errors. Implications and alternative models are discussed.

  6. Parental age and the origin of trisomy 21. A study of 302 families.

    PubMed

    Dagna Bricarelli, F; Pierluigi, M; Landucci, M; Arslanian, A; Coviello, D A; Ferro, M A; Strigini, P

    1989-04-01

    Several studies have attempted to define the role of parental age in determining the prevalence of 47, +21 according to the origin of nondisjunction. This report analyzes the original data of 197 informative families from Italy and reviews the available literature (96 families from Denmark and 201 from other countries). Mothers whose gametes showed nondisjunction are treated as cases, and those with normal meiosis as controls within each study. To utilize the data fully, maternal age at birth of a 47, +21 individual is treated as a continuous variable in a nonparametric comparison. The combined evidence indicates that nondisjunction in the female is associated with a significant age difference between cases and controls which is mostly due to errors in the second meiotic division. It may be inferred that in the general population, aging enhances nondisjunction at both first and second division in the female, while aging in the male is presumably associated mostly (or only) with first division errors. Implications and alternative models are discussed. PMID:2523851

  7. Comparable ages for the independent origins of electrogenesis in African and South American weakly electric fishes.

    PubMed

    Lavoué, Sébastien; Miya, Masaki; Arnegard, Matthew E; Sullivan, John P; Hopkins, Carl D; Nishida, Mutsumi

    2012-01-01

    One of the most remarkable examples of convergent evolution among vertebrates is illustrated by the independent origins of an active electric sense in South American and African weakly electric fishes, the Gymnotiformes and Mormyroidea, respectively. These groups independently evolved similar complex systems for object localization and communication via the generation and reception of weak electric fields. While good estimates of divergence times are critical to understanding the temporal context for the evolution and diversification of these two groups, their respective ages have been difficult to estimate due to the absence of an informative fossil record, use of strict molecular clock models in previous studies, and/or incomplete taxonomic sampling. Here, we examine the timing of the origins of the Gymnotiformes and the Mormyroidea using complete mitogenome sequences and a parametric bayesian method for divergence time reconstruction. Under two different fossil-based calibration methods, we estimated similar ages for the independent origins of the Mormyroidea and Gymnotiformes. Our absolute estimates for the origins of these groups either slightly postdate, or just predate, the final separation of Africa and South America by continental drift. The most recent common ancestor of the Mormyroidea and Gymnotiformes was found to be a non-electrogenic basal teleost living more than 85 millions years earlier. For both electric fish lineages, we also estimated similar intervals (16-19 or 22-26 million years, depending on calibration method) between the appearance of electroreception and the origin of myogenic electric organs, providing rough upper estimates for the time periods during which these complex electric organs evolved de novo from skeletal muscle precursors. The fact that the Gymnotiformes and Mormyroidea are of similar age enhances the comparative value of the weakly electric fish system for investigating pathways to evolutionary novelty, as well as the

  8. The Age Specific Incidence Anomaly Suggests that Cancers Originate During Development

    NASA Astrophysics Data System (ADS)

    Brody, James P.

    2014-05-01

    The accumulation of genetic alterations causes cancers. Since this accumulation takes time, the incidence of most cancers is thought to increase exponentially with age. However, careful measurements of the age-specific incidence show that the specific incidence for many forms of cancer rises with age to a maximum, and then decreases. This decrease in the age-specific incidence with age is an anomaly. Understanding this anomaly should lead to a better understanding of how tumors develop and grow. Here we derive the shape of the age-specific incidence, showing that it should follow the shape of a Weibull distribution. Measurements indicate that the age-specific incidence for colon cancer does indeed follow a Weibull distribution. This analysis leads to the interpretation that for colon cancer two subpopulations exist in the general population: a susceptible population and an immune population. Colon tumors will only occur in the susceptible population. This analysis is consistent with the developmental origins of disease hypothesis and generalizable to many other common forms of cancer.

  9. The Age Specific Incidence Anomaly Suggests that Cancers Originate During Development

    NASA Astrophysics Data System (ADS)

    Brody, James P.

    The accumulation of genetic alterations causes cancers. Since this accumulation takes time, the incidence of most cancers is thought to increase exponentially with age. However, careful measurements of the age-specific incidence show that the specific incidence for many forms of cancer rises with age to a maximum, and then decreases. This decrease in the age-specific incidence with age is an anomaly. Understanding this anomaly should lead to a better understanding of how tumors develop and grow. Here we derive the shape of the age-specific incidence, showing that it should follow the shape of a Weibull distribution. Measurements indicate that the age-specific incidence for colon cancer does indeed follow a Weibull distribution. This analysis leads to the interpretation that for colon cancer two subpopulations exist in the general population: a susceptible population and an immune population. Colon tumors will only occur in the susceptible population. This analysis is consistent with the developmental origins of disease hypothesis and generalizable to many other common forms of cancer.

  10. Origin of the cannula for tracheotomy during the middle ages and Renaissance.

    PubMed

    Missori, Paolo; Brunetto, Giacoma M; Domenicucci, Maurizio

    2012-04-01

    The purpose of this article was to trace the historical origin of the inserted cannula during tracheotomy. Tracheotomy is mentioned in most ancient medical texts, but the origin of cannula insertion into the windpipe is unclear. We reviewed the incunabula and Renaissance texts reporting the utilization of surgical cannulas and tracheotomy. The incunabula disclosed extended use of surgical cannulas during the middle ages and Renaissance. Although tracheotomy was advocated in acutely suffocating patients for a disease of the throat termed squinantia or angina, the first report of the procedure was found only at the end of the middle ages and a second during the middle Renaissance. The introduction of cannula use in tracheotomy was supported by a semantic misinterpretation by Antonio Musa Brasavola. The historical origin for tracheotomy in the middle ages and Renaissance is conflicting. Antonio Brasavola wrongly interpreted Avicenna's oral cannula introduced into the windpipe for angina. This misinterpretation allowed Giulio Casserio to draw the first curved cannula introduced for used during tracheotomy.

  11. 78 FR 9708 - National Institute on Aging Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute on Aging Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Comparative Physiology of Aging. Date:...

  12. 75 FR 11188 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel, Nursing Home Research. Date: May 7, 2010... Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892. (Telephone...

  13. 78 FR 4423 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Worm Intervention Study. Date: February 20... Institute on Aging, Gateway Building, Suite 2C212, 7201 Wisconsin Avenue, Bethesda, MD 20892,...

  14. 77 FR 56855 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Skeletal Muscle. ] Date: October 23, 2012... Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892...

  15. 77 FR 65005 - National Institute on Aging Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-24

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Juvenile Protective Factors. Date: December 4... Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892. Contact...

  16. 78 FR 36200 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-17

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Longitudinal Study Contract. Date: June 26... Institute on Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20814,...

  17. 77 FR 21790 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Loan Repayment 2012. Date: May 2, 2012. Time... Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892. Contact Person:...

  18. 77 FR 2737 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-19

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Network Facilities for Developing Areas of Investigation in the Basic Biology of Aging. Date: February 9, 2012. Time: 8:30 a.m. to 9:30 a.m. Agenda:...

  19. 78 FR 9403 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-08

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; CALERIE Dataset. Date: March 7, 2013. Time: 1... Aging, Gateway Building, Room 2C212, 7201 Wisconsin Avenue, Bethesda, MD 20892, (Telephone...

  20. 77 FR 5030 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel Testosterone Studies. Date: February 16, 2012... Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892, (Telephone...

  1. 76 FR 35901 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-20

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel, Signal Transduction. Date: July 12, 2011... Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892, (Telephone...

  2. 76 FR 28794 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-18

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel, Longevity Consortium. Date: June 9, 2011... Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892, (Telephone...

  3. 75 FR 3476 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; Clinical Services. Date: January 29, 2010... Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892. (Telephone...

  4. 78 FR 32408 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-30

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel Senile Dementia. Date: June 28, 2013. Time: 1... Aging, Gateway Building, Suite 2C212, 7201 Wisconsin Avenue, Bethesda, MD 20892, (Telephone...

  5. 78 FR 57167 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-17

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel; Disability and Employment. Date: October 17... Institute on Aging, Gateway Building, Suite 2C212, 7201 Wisconsin Avenue, Bethesda, MD 20892. Contact...

  6. 75 FR 39549 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-09

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel; ARRA--MIND MRI. Date: July 26, 2010. Time: 1... Aging, Gateway Building, 7201 Wisconsin Avenue, Suite 2C212. Bethesda, MD 20892. (Telephone...

  7. 23 CFR 1208.4 - Adoption of National Minimum Drinking Age.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 23 Highways 1 2014-04-01 2014-04-01 false Adoption of National Minimum Drinking Age. 1208.4..., DEPARTMENT OF TRANSPORTATION GUIDELINES NATIONAL MINIMUM DRINKING AGE § 1208.4 Adoption of National Minimum Drinking Age. The Secretary shall withhold ten percent of the amount required to be apportioned to...

  8. 23 CFR 1208.4 - Adoption of National Minimum Drinking Age.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 23 Highways 1 2012-04-01 2012-04-01 false Adoption of National Minimum Drinking Age. 1208.4..., DEPARTMENT OF TRANSPORTATION GUIDELINES NATIONAL MINIMUM DRINKING AGE § 1208.4 Adoption of National Minimum Drinking Age. The Secretary shall withhold ten percent of the amount required to be apportioned to...

  9. 23 CFR 1208.4 - Adoption of National Minimum Drinking Age.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false Adoption of National Minimum Drinking Age. 1208.4..., DEPARTMENT OF TRANSPORTATION GUIDELINES NATIONAL MINIMUM DRINKING AGE § 1208.4 Adoption of National Minimum Drinking Age. The Secretary shall withhold ten percent of the amount required to be apportioned to...

  10. 23 CFR 1208.4 - Adoption of National Minimum Drinking Age.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Adoption of National Minimum Drinking Age. 1208.4..., DEPARTMENT OF TRANSPORTATION GUIDELINES NATIONAL MINIMUM DRINKING AGE § 1208.4 Adoption of National Minimum Drinking Age. The Secretary shall withhold ten percent of the amount required to be apportioned to...

  11. Two-year citations of JAPPL original articles: evidence of a relative age effect.

    PubMed

    Soares de Araújo, Claudio Gil; de Araújo, Claudio Gil Soares; Ramalho de Oliveira, Bruno Ribeiro; de Oliveira, Bruno Ribeiro Ramalho; de Oliveira Brito, Letícia Vargas; da Matta, Thiago Torres; Viana, Bruno Ferreira; de Souza, Cintia Pereira; Guerreiro, Renato de Carvalho; de Carvalho Guerreiro, Renato; Slama, Fabian Antonio; Portugal, Eduardo da Matta Mello; da Matta Mello Portugal, Eduardo

    2012-05-01

    Several indicators have been used to analyze scientific journals, with the impact factor and the number of citations in a 2-yr calendar time frame (2-YRC) being the most common factors. However, considering that the Journal of Applied Physiology (JAPPL) appears monthly and that calculations of these indicators are based on citations of papers published in previous years, we hypothesized that articles published at the beginning of the year would be cited more in the 2-YRC compared with those appearing in the last issues of the year, a phenomena known as a relative age effect. Our objective was to confirm the existence of a relative age effect in the 2-YRC for original articles published in JAPPL. From 2005 to 2008, a total of 1,726 original articles were published, according to the Web of Science, and 9,973 citations in 2-YRC, varying from 0 to 45, with a mean of 5.78 for individual papers. Although there were no differences in the number of original articles published in a given month (P = 0.99), the 2-YRC varied considerably throughout the year, being higher for those earlier issues of the year, as shown by the linear regression analysis (r(2) = 0.76; P < 0.001). The 2-YRC began at 6.62 during the first 3 mo of the year, dropping by 10% at each 3-mo period. In summary, the longer an article has been out there, the more citations it collects. The relative age effect is a potential confounding variable for the assessment and interpretation of 2-YRC (using calendar years) from JAPPL original articles.

  12. 23 CFR 1208.4 - Adoption of National Minimum Drinking Age.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false Adoption of National Minimum Drinking Age. 1208.4 Section 1208.4 Highways NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION AND FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GUIDELINES NATIONAL MINIMUM DRINKING AGE § 1208.4 Adoption of National...

  13. 78 FR 35041 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-11

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel SWAN. Date: June 27, 2013. Time: 9:30 a.m. to 12:30 p.m. Agenda: To review and evaluate grant applications. Place: National Institute on...

  14. 76 FR 23827 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-28

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Committee: National Institute on Aging Special Emphasis Panel Osteoarthritis. Date: June 8, 2011. Time: 9 a.m. to 1 p.m. Agenda: To review and evaluate grant applications. Place: National Institute on...

  15. 75 FR 18511 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-12

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel, Loan Repayment. Date: May 3, 2010. Time: 12 p.m. to 4 p.m. Agenda: To review and evaluate grant applications. Place: National Institute on...

  16. 78 FR 16273 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-14

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting... Committee: National Institute on Aging Special Emphasis Panel. Date: April 1, 2013. Time: 12:00 p.m. to 12:30 p.m. Agenda: To review and evaluate grant applications. Place: National Institute on...

  17. 76 FR 11798 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-03

    ... HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting..., National Institutes of Health, 7201 Wisconsin Avenue, Suite 2C-212, Bethesda, MD 20892, 301-402- 7700....866, Aging Research, National Institutes of Health, HHS) Dated: February 25, 2011. Jennifer S....

  18. 75 FR 8374 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ... Committee: National Institute on Aging Special Emphasis Panel, New Invertebrate Models for the Biology of... Institute on Aging Special Emphasis Panel, Behavioral Economics, Health and Aging. Date: March 31,...

  19. Country of origin, age at migration and risk of cutaneous melanoma: a migrant cohort study of 1,100,000 Israeli men.

    PubMed

    Levine, Hagai; Afek, Arnon; Shamiss, Ari; Derazne, Estela; Tzur, Dorit; Astman, Nadav; Keinan-Boker, Lital; Mimouni, Daniel; Kark, Jeremy D

    2013-07-15

    Cutaneous melanoma (CM) is a common cancer with increasing incidence in many parts of the world where light-skinned populations live. We conducted a large-scale nationally representative migrant cohort study to assess country of origin and age at migration as predictors of CM, controlling for possible confounders. Data on 1,086,569 Israeli Jewish males, who underwent a general health examination before compulsory military service at ages 16-19 between the years 1967-2005, were linked to Israel National Cancer Registry to obtain incident CM up to 2006. Cox proportional hazards was used to model time to event. Overall, 1562 incident cases were detected during 19.3 million person-years of follow-up. Origin was a strong independent predictor of CM. Incidence was higher for European (hazard ratio [HR] = 4.08, 95% confidence interval [CI]: 3.55-4.67) and Israeli origin (HR = 2.92, 95% CI: 2.25-3.79) compared to N. African/Asian origin, adjusted for year of birth, years of education, residential socio-economic position, rural residence and body surface area (or height). Among those of European origin, the adjusted risk was significantly lower for those who immigrated after the age of 10 years (HR = 0.58, 95% CI: 0.45-0.73) but not for younger ages (HR = 1.02, 95% CI 0.84-1.23) compared to Israeli born. The high rates of CM among men of European origin and the almost twofold lower risk among those immigrating after age 10 provide solid support for the deleterious role of childhood sun exposure as a risk factor for melanoma. These findings will serve in directing public health and research efforts.

  20. Origins.

    ERIC Educational Resources Information Center

    Online-Offline, 1999

    1999-01-01

    Provides an annotated list of resources dealing with the theme of origins of life, the universe, and traditions. Includes Web sites, videos, books, audio materials, and magazines with appropriate grade levels and/or subject disciplines indicated; professional resources; and learning activities. (LRW)

  1. Unmarried Boomers Confront Old Age: A National Portrait

    PubMed Central

    Lin, I-Fen; Brown, Susan L.

    2012-01-01

    Purpose of the Study: Our study provides a national portrait of the Baby Boom generation, paying particular attention to the heterogeneity among unmarried Boomers and whether it operates similarly among women versus men. Design and Methods: We used the 1980, 1990, and 2000 Census 5% samples and the 2009 American Community Survey (ACS) to document the trends in the share and marital status composition of the unmarried population during midlife. Using the 2009 ACS, we developed a sociodemographic portrait of Baby Boomers according to marital status. Results: One in three Baby Boomers was unmarried. The vast majority of these unmarried Boomers were either divorced or never-married; just 10% were widowed. Unmarried Boomers faced greater economic, health, and social vulnerabilities compared to married Boomers. Divorced Boomers had more economic resources and better health than widowed and never-married Boomers. Widows appeared to be the most disadvantaged among Boomer women, whereas never-marrieds were the least advantaged among Boomer men. Implications: The rise in unmarrieds at midlife leaves Baby Boomers vulnerable to the vagaries of aging. Health care and social service providers as well as policy makers must recognize the various risk profiles of different unmarried Boomers to ensure that all Boomers age well and that society is able to provide adequate services to all Boomers, regardless of marital status. PMID:22298744

  2. Origins.

    PubMed

    Weinberg, S

    1985-10-01

    The farthest of the galaxies that can be seen through the large ground-based telescopes of modern astronomy, such as those on La Palma in the Canary Islands, are so far away that they appear as they did close to the time of the origin of the universe, perhaps some 10 billion years ago. Much has been learned, and much has still to be learned, about the young universe from optical and radio telescopes, but these instruments cannot be used to look directly at the universe in its first few hundred thousand years. Instead, they are used to search the relatively recent past for relics of much earlier times. Together with experiments planned for the next generation of elementary particle accelerators, astronomical observations should continue to extend what is known about the universe backward in time to the Big Bang and may eventually help to reveal the origins of the physical laws that govern the universe.

  3. Sm-Nd evidence for the age and origin of a Mississippi Valley Type ore deposit.

    PubMed

    Halliday, A N; Shepherd, T J; Dickin, A P; Chesley, J T

    1990-03-01

    MISSISSIPPI Valley Type (MVT) ore deposits represent the relatively common product of large-scale fluid transport in the continental lithosphere, yet the models for their genesis have been more controversial and unconstrained than those of any other class of giant ore deposit(1,2). Here we show that Sm-Nd isotope data can be used to determine the age and origin of an MVT deposit. Sm-Nd data for fluorites from the North Pennine orefield are difficult to explain unless some of the mineralization is of Mesozoic rather than the traditionally accepted Palaeozoic age. Furthermore, the Nd and Sr isotopie compositions of the fluorites do not support a variety of recent models that include derivation of the components from the mantle, the Lower Palaeozoic basement or the underlying buried granite which served to focus the flow of hydrothermal fluids.

  4. Sm-Nd evidence for the age and origin of a Mississippi Valley Type ore deposit.

    PubMed

    Halliday, A N; Shepherd, T J; Dickin, A P; Chesley, J T

    1990-03-01

    MISSISSIPPI Valley Type (MVT) ore deposits represent the relatively common product of large-scale fluid transport in the continental lithosphere, yet the models for their genesis have been more controversial and unconstrained than those of any other class of giant ore deposit(1,2). Here we show that Sm-Nd isotope data can be used to determine the age and origin of an MVT deposit. Sm-Nd data for fluorites from the North Pennine orefield are difficult to explain unless some of the mineralization is of Mesozoic rather than the traditionally accepted Palaeozoic age. Furthermore, the Nd and Sr isotopie compositions of the fluorites do not support a variety of recent models that include derivation of the components from the mantle, the Lower Palaeozoic basement or the underlying buried granite which served to focus the flow of hydrothermal fluids. PMID:18278025

  5. On the origin and age of the Great Sand Dunes, Colorado

    USGS Publications Warehouse

    Madole, R.F.; Romig, J.H.; Aleinikoff, J.N.; VanSistine, D.P.; Yacob, E.Y.

    2008-01-01

    Over the past 100??yr, several hypotheses have been proposed for the origin and age of the Great Sand Dunes. These hypotheses differ widely in the descriptions of dune morphometry, the immediate source of eolian sand, and when sand transport occurred. The primary purpose of this paper is to evaluate these hypotheses and, where warranted, to present new ideas about the origin and age of the Great Sand Dunes. To evaluate the previous hypotheses, we had to develop more detailed information about the surficial geology of the northern San Luis Valley. Thus, we mapped the surficial geology of an area extending several tens of kilometers north, south, and west of the Great Sand Dunes and examined subsurface stratigraphy in more than 200 wells and borings. In addition, we used relative-dating criteria and several radiocarbon and OSL ages to establish the chronology of surficial deposits, and we determined the U-Pb ages of detrital zircons to obtain information about the sources of the sand in the Great Sand Dunes. The first principal finding of this study is that the lower part of the closed basin north of the Rio Grande, referred to here as the sump, is the immediate source of the sand in the Great Sand Dunes, rather than the late Pleistocene flood plain of the Rio Grande (the most widely accepted hypothesis). A second principal finding is that the Great Sand Dunes are older than late Pleistocene. They postdate the draining of Lake Alamosa, which began ??? 440??ka, and predate the time when streams draining the west flank of the Sangre de Cristo Mountains were deflected by incipient dunes that formed near the mountain front. Geomorphic and stratigraphic evidence indicate that this deflection occurred prior to the end of the next to last glaciation (Bull Lake), i.e., prior to ??? 130??ka.

  6. Impact Constraints on the Age and Origin of the Crustal Dichotomy on Mars

    NASA Technical Reports Server (NTRS)

    Frey, Herbert V.

    2004-01-01

    MOLA data have revealed a large population of 'Quasi-Circular Depressions' (QCDs) with little or no visible expression in image data. These likely buried impact basins have important implications for the age of the lowland crust, how that compares with original highland crust, and when and how the crustal dichotomy may have formed. The buried lowlands are of Early Noachian age, likely slightly younger than the buried highlands but older than the exposed (visible) highland surface. A depopulation of large visible basins at diameters 800 to 1300 km suggests some global scale event early in martian history, maybe related to the formation of the lowlands and/or the development of Tharsis. A suggested early disappearance of the global magnetic field can be placed within a temporal sequence of formation of the very largest impact basins. The global field appears to have disappeared at about the time the lowlands formed. It seems likely the topographic crustal dichotomy was produced very early in martian history by processes which operated very quickly. This and the preservation of large relic impact basins in the northern hemisphere, which themselves can account for the lowland topography, suggest that large impacts played the major role in the origin Mars fundamental crustal feature.

  7. Impact Constraints on the Age and Origin of the Crustal Dichotomy on Mars

    NASA Technical Reports Server (NTRS)

    Frey, H. V.

    2004-01-01

    MOLA data have revealed a large population of "Quasi-Circular Depressions" (QCDs) with little or no visible expression in image data. These likely buried impact basins have important implications for the age of the lowland crust, how that compares with original highland crust, and when and how the crustal dichotomy may have formed. The buried lowlands are of Early Noachian age, likely slightly younger than the buried highlands but older than the exposed (visible) highland surface. A depopulation of large visible basins at diameters 800 to 1300 km suggests some global scale event early in martian history, maybe related to the formation of the lowlands andor the development of Tharsis. A suggested early disappearance of the global magnetic field can be placed within a temporal sequence of formation of the very largest impact basins. The global field appears to have disappeared at about the time the lowlands formed. It seems likely the topographic crustal dichotomy was produced very early in martian history by processes which operated very quickly. This and the preservation of large relic impact basins in the north- em hemisphere, which themselves can account for the lowland topography, suggest that large impacts played the major role in the origin Mars fundamental crustal feature.

  8. 75 FR 28031 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-19

    ... provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant...: Jeannette L. Johnson, PhD, Scientific Review Officer, National Institutes On Aging, National Institutes of..., PhD, Scientific Review Officer, Scientific Review Branch, National Institute On Aging, Gateway...

  9. 78 FR 66369 - National Institute on Aging; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-05

    ... Federal Register on September 17, 2013, 57167 FR 180. Meeting will be held on December 19, 2013 from 12:00... HUMAN SERVICES National Institutes of Health National Institute on Aging; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Institute on Aging Special...

  10. 78 FR 66373 - National Institute on Aging; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-05

    ... Federal Register on September 25, 2013, 59042- 59043 FR 186. Meeting will be held December 12, 2013 from... HUMAN SERVICES National Institutes of Health National Institute on Aging; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Institute on Aging Special...

  11. 78 FR 66368 - National Institute on Aging; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-05

    ... Federal Register on September 17, 2013, 78 FR 57167. Meeting will be held on November 26, 2013 from 1:00 p... HUMAN SERVICES National Institutes of Health National Institute on Aging; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Institute on Aging Special...

  12. 77 FR 74677 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-17

    ... Committee: National Institute on Aging Special Emphasis Panel; Cell Dependent and Independent Mechanism... applications. Place: National Institute on Aging, Gateway Building, Suite 2C212, 7201 Wisconsin Avenue...:00 p.m. to 4:00 p.m. Agenda: To review and evaluate grant applications. Place: National Institute...

  13. Ages, distributions, and origins of upland coastal dune sheets in Oregon, USA

    USGS Publications Warehouse

    Peterson, C.D.; Stock, E.; Price, D.M.; Hart, R.; Reckendorf, F.; Erlandson, J.M.; Hostetler, S.W.

    2007-01-01

    A total of ten upland dune sheets, totaling 245??km in combined length, have been investigated for their origin(s) along the Oregon coast (500??km in length). The ages of dune emplacement range from 0.1 to 103??ka based on radiocarbon (36 samples) and luminescence (46 samples) dating techniques. The majority of the emplacement dates fall into two periods of late-Pleistocene age (11-103??ka) and mid-late-Holocene age (0.1-8??ka) that correspond to marine low-stand and marine high-stand conditions, respectively. The distribution of both the late-Pleistocene dune sheets (516??km2 total surface area) and the late-Holocene dune sheets (184??km2) are concentrated (90% of total surface area) along a 100??km coastal reach of the south-central Oregon coast. This coastal reach lies directly landward of a major bight (Heceta-Perpetua-Stonewall Banks) on the continental shelf, at depths of 30-200??m below present mean sea level (MSL). The banks served to trap northward littoral drift during most of the late-Pleistocene conditions of lowered sea level (- 50 ?? 20??m MSL). The emerged inner-shelf permitted cross-shelf, eolian sand transport (10-50??km distance) by onshore winds. The depocenter sand deposits were reworked by the Holocene marine transgression and carried landward by asymmetric wave transport during early- to mid-Holocene time. The earliest dated onset of Holocene dune accretion occurred at 8??ka in the central Oregon coast. A northward migration of Northeast Pacific storm tracks to the latitude of the shelf depocenter (Stonewall, Perpetua, Heceta Banks) in Holocene time resulted in eastward wave transport from the offshore depocenter. The complex interplay of coastal morphology, paleosea-level, and paleoclimate yielded the observed peak distribution of beach and dune sand observed along the south-central Oregon coast. ?? 2007 Elsevier B.V. All rights reserved.

  14. Snow-avalanche impact landforms in Breheimen, southern Norway: Origin, age, and paleoclimatic implications

    SciTech Connect

    Matthews, J.A.; McCarroll, D. )

    1994-05-01

    Twelve snow-avalanche ramparts in Jostedalen and Sprongdalen (Breheimen, southern Norway) are investigated to elucidate processes of formation, the history of avalanche activity, and their potential for paleoclimatic reconstruction. Variation in the form of these riverbank boulder ramparts reflects local patterns of avalanche impact. Differences in clast roundness between ramparts, avalanche tracks, and river beds indicate that, on average, 50 to 60% of the clasts in the ramparts originate from river bedload as opposed to avalanche source areas or tracks. Rampart clasts increase in roundness downstream over a distance of 12 km, and the contribution from the river bed varies from 26 to 80% depending on local factors. Conventional lichenometric dating suggests ages for the initiation of rampart formation of 250 to 2000 yr, but they probably have a much longer history. Lichen-size frequency distributions, using the largest lichen from each of n boulders, reflect the age-frequency of surface boulders, providing a record of late Holocene avalanche activity. A simulation model suggests that maximum avalanche activity affected nine of the ramparts during the 19th century, after the peak of the Little Ice Age. The pattern of avalanche activity differs from the pattern of glacier variations but is in close agreement with that of debris-flow activity. The ramparts may yield a valuable proxy record of winter snowfall. 48 refs., 12 figs., 4 tabs.

  15. Lunar crater arcs. [origins, distribution and age classification of Pre-Imbrian families

    NASA Technical Reports Server (NTRS)

    Jaffe, L. D.; Bulkley, E. O.

    1976-01-01

    An analysis has been made of the tendency of large lunar craters to lie along circles. A catalog of the craters at least 50 km in diameter was prepared first, noting position, diameter, rim sharpness and completion, nature of underlying surface, and geological age. The subset of those craters 50-400 km in diameter was then used as input to computer programs which identified each 'family' of four or more craters of selected geological age lying on a circular arc. For comparison, families were also identified for randomized crater models in which the crater spatial density was matched to that on the moon, either overall or separately for mare and highland areas. The observed frequency of lunar arcuate families was statistically highly significantly greater than for the randomized models, for craters classified as either late-pre-Imbrian (Nectarian), middle pre-Imbrian, or early pre-Imbrian, as well as for a number of larger age-classes. The lunar families tend to center in specific areas of the moon; these lie in highlands rather than maria and are different for families of Nectarian craters than for pre-Nectarian. The origin of the arcuate crater groupings is not understood.

  16. Teen-Age Pregnancy: The Case for National Action.

    ERIC Educational Resources Information Center

    Wattleton, Faye

    1989-01-01

    Reviews the national impact of adolescent pregnancy with emphasis on the Black community. Criticizes the mass media for exploiting sexual behavior. Proposes a national agenda incorporating comprehensive sex education, family planning services, and educational, economic, and social opportunities. (FMW)

  17. Ages and Origins of Calcite and Opal in the Exploratory Studies Facility Tunnel, Yucca Mountain, Nevada

    USGS Publications Warehouse

    Paces, James B.; Neymark, Leonid A.; Marshall, Brian D.; Whelan, Joseph F.; Peterman, Zell E.

    2001-01-01

    and smallest delta oxygen-18 values compared to calcite from intermediate and outer positions. Basal calcite has relatively small strontium-87/strontium-86 ratios, between 0.7105 and 0.7120, that are similar to the initial isotopic compositions of the strontium-rich tuff units, whereas outer calcite has more radiogenic strontium-87/strontium-86 ratios between 0.7115 and 0.7127. Isotopic compositions of strontium, oxygen, and carbon in the outer (youngest) unsaturated-zone calcite are coincident with those measured in Yucca Mountain calcrete, which formed by pedogenic processes. The physical and isotopic data from calcite and opal indicate that they formed from solutions of meteoric origin percolating through a limited network of connected fracture pathways in the unsaturated zone rather than by inundation from ascending ground water originating in the saturated zone. Mineral assemblages, textures, and distributions within the unsaturated zone are distinctly different from those deposited below the water table at Yucca Mountain. The calcite and opal typically are present only on footwall surfaces of a small fraction of fractures and only on floors of a small fraction of lithophysal cavities. The similarities in the carbon, oxygen, and strontium isotopic compositions between fracture calcite and soil-zone calcite, as well as the gradation of textures from detritus-rich micrite in the soil to detritus-free spar 10 to 30 meters below the surface, also support a genetic link between the two depositional environments. Older deposits contain oxygen isotope compositions that indicate elevated temperatures of mineral formation during the early stages of deposition; however, in the youngest deposits these values are consistent with deposition under geothermal gradients similar to modern conditions. Correlations between mineral ages and varying Pleistocene climate conditions are not apparent from the current data. Cumulative evidence from calcite and opal deposits indicate

  18. Initial insights into the age and origin of the Kubuqi sand sea of northern China

    NASA Astrophysics Data System (ADS)

    Yang, Xiaoping; Forman, Steven; Hu, Fangen; Zhang, Deguo; Liu, Ziting; Li, Hongwei

    2016-04-01

    The Kubuqi Desert is the only active sand sea in the semiarid regions of northern China and occurs along the southern margin of the Yellow River. Little is known about the age and origin of this large (17,000 km2) sand sea with a present annual precipitation of 200-480 mm. Sand drift potentials indicated net capable winds for aeolian transport are from the northwest, though winds are stronger to north beyond the dune field than within the sand sea. Geomorphic and stratigraphic observations indicate that Holocene aeolian sand often drapes over bedrock and river terraces as a palimpsest landscape. Field investigations identified four stratigraphic sections with multiple aeolian sand units and palaeosols, with age control by optically stimulated luminescence (OSL) dating of quartz grains. Palaeosols are weakly developed, mostly accumulative A horizon with organic carbon content < 1% and reflect sand sheet deposition possibly in a steppe environment. Although sediments near river channels or former lakes might give old ages, the initial formation and age of the Kubuqi sand sea should be judged from the occurrence of the sandy palimpsest of the landscape that is OSL dated to the Holocene in general. The latest period of aeolian reactivation may be related to human activity associated with grazing and farming from lost cities in the Kubuqi Desert during the Han (206 B.C. - A.D. 220) and the Tang (A.D. 608 - 907) Dynasties. Also, variable discharge of the Yellow River with local diversions for irrigation and throughout the catchment resulted in possibly an increased supply of aeolian particles for dune field expansion in the past 2 ka.

  19. Subduction Along the South Caribbean Deformed Belt: Age of Initiation and Backthrust Origin

    NASA Astrophysics Data System (ADS)

    Mann, P.; Kroehler, M.; Escalona, A.; Magnani, B.; Christeson, G.

    2007-12-01

    The South Caribbean deformed belt (SCDB) represents a submarine prism formed at the interface between subducting oceanic material in the Colombian and Venezuelan basins and arc terranes along the northern edge of the South American continent. The SCDB and subducted Caribbean slab extends 1500 km from Panama to the Aves Ridge and is similar in scale to better studied magmatic subduction zones in the Lesser Antilles and Central America. The age of subduction of the Venezuelan basin at the SCDB has been examined by dating asymmetrical sediment wedges inferred to have formed above the bending and subducting slab of the Venezuelan basin. Ages are constrained by ties to DSDP wells drilled in the Venezuelan basin ~150 km north of the SCDB. Onlapping wedges are oldest in the western area near the Beata Ridge (middle Eocene), of intermediate age in the central area (early Miocene), and youngest in the east near the Aves Ridge (Mio- Pleistocene). Overlying younger wedges in all areas demonstrate that subduction continued following its initiation. Similar ages of deformed syn-thurst wedges are known from the now inactive continental foreland of northern South America in a belt from western Venezuela to Trinidad. Based on this correlation, we propose a simple back arc thrusting origin for the SCDB that is analogous to the eastern Sunda arc of Indonesia. The obliquity of convergence in the Caribbean case has produced a longlived, eastwardly-migrating backthrust that contrasts to more static backthrust in Sunda. The immediate onset of backthrusting following continental collision means that South America-Caribbean convergence was accommodated by newly organized and focussed subduction at the SCDB backthrust; the "collided" crust of intervening accreted arc terranes remains remarkably unaffected by regional shortening effects.

  20. 13 CFR 113.3-1 - Consideration of race, color, religion, sex, marital status, handicap, or national origin.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., religion, sex, marital status, handicap, or national origin. 113.3-1 Section 113.3-1 Business Credit and... of race, color, religion, sex, marital status, handicap, or national origin. (a) This regulation does not prohibit the consideration of race, color, religion, sex, marital status, handicap, or...

  1. 13 CFR 113.3-1 - Consideration of race, color, religion, sex, marital status, handicap, or national origin.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., religion, sex, marital status, handicap, or national origin. 113.3-1 Section 113.3-1 Business Credit and... of race, color, religion, sex, marital status, handicap, or national origin. (a) This regulation does not prohibit the consideration of race, color, religion, sex, marital status, handicap, or...

  2. 13 CFR 113.3-1 - Consideration of race, color, religion, sex, marital status, handicap, or national origin.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., religion, sex, marital status, handicap, or national origin. 113.3-1 Section 113.3-1 Business Credit and... of race, color, religion, sex, marital status, handicap, or national origin. (a) This regulation does not prohibit the consideration of race, color, religion, sex, marital status, handicap, or...

  3. 13 CFR 113.3-1 - Consideration of race, color, religion, sex, marital status, handicap, or national origin.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., religion, sex, marital status, handicap, or national origin. 113.3-1 Section 113.3-1 Business Credit and... of race, color, religion, sex, marital status, handicap, or national origin. (a) This regulation does not prohibit the consideration of race, color, religion, sex, marital status, handicap, or...

  4. 13 CFR 113.3-1 - Consideration of race, color, religion, sex, marital status, handicap, or national origin.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., religion, sex, marital status, handicap, or national origin. 113.3-1 Section 113.3-1 Business Credit and... of race, color, religion, sex, marital status, handicap, or national origin. (a) This regulation does not prohibit the consideration of race, color, religion, sex, marital status, handicap, or...

  5. 42 CFR 21.52 - Waiver of entrance qualifications for original appointment in time of war or national emergency.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Waiver of entrance qualifications for original appointment in time of war or national emergency. 21.52 Section 21.52 Public Health PUBLIC HEALTH SERVICE... entrance qualifications for original appointment in time of war or national emergency. If, in time of...

  6. 41 CFR 102-36.445 - Do we report excess personal property originally acquired from or through the American National...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... personal property originally acquired from or through the American National Red Cross? 102-36.445 Section... Personal Property Whose Disposal Requires Special Handling Red Cross Property § 102-36.445 Do we report excess personal property originally acquired from or through the American National Red Cross? Yes,...

  7. 41 CFR 102-36.445 - Do we report excess personal property originally acquired from or through the American National...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... personal property originally acquired from or through the American National Red Cross? 102-36.445 Section... Personal Property Whose Disposal Requires Special Handling Red Cross Property § 102-36.445 Do we report excess personal property originally acquired from or through the American National Red Cross? Yes,...

  8. 41 CFR 102-36.445 - Do we report excess personal property originally acquired from or through the American National...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... personal property originally acquired from or through the American National Red Cross? 102-36.445 Section... Personal Property Whose Disposal Requires Special Handling Red Cross Property § 102-36.445 Do we report excess personal property originally acquired from or through the American National Red Cross? Yes,...

  9. 41 CFR 102-36.445 - Do we report excess personal property originally acquired from or through the American National...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... personal property originally acquired from or through the American National Red Cross? 102-36.445 Section... Personal Property Whose Disposal Requires Special Handling Red Cross Property § 102-36.445 Do we report excess personal property originally acquired from or through the American National Red Cross? Yes,...

  10. 41 CFR 102-36.445 - Do we report excess personal property originally acquired from or through the American National...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... personal property originally acquired from or through the American National Red Cross? 102-36.445 Section... Personal Property Whose Disposal Requires Special Handling Red Cross Property § 102-36.445 Do we report excess personal property originally acquired from or through the American National Red Cross? Yes,...

  11. 42 CFR 21.52 - Waiver of entrance qualifications for original appointment in time of war or national emergency.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Waiver of entrance qualifications for original appointment in time of war or national emergency. 21.52 Section 21.52 Public Health PUBLIC HEALTH SERVICE... entrance qualifications for original appointment in time of war or national emergency. If, in time of...

  12. 42 CFR 21.52 - Waiver of entrance qualifications for original appointment in time of war or national emergency.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Waiver of entrance qualifications for original appointment in time of war or national emergency. 21.52 Section 21.52 Public Health PUBLIC HEALTH SERVICE... entrance qualifications for original appointment in time of war or national emergency. If, in time of...

  13. 42 CFR 21.52 - Waiver of entrance qualifications for original appointment in time of war or national emergency.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Waiver of entrance qualifications for original appointment in time of war or national emergency. 21.52 Section 21.52 Public Health PUBLIC HEALTH SERVICE... entrance qualifications for original appointment in time of war or national emergency. If, in time of...

  14. 42 CFR 21.52 - Waiver of entrance qualifications for original appointment in time of war or national emergency.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Waiver of entrance qualifications for original appointment in time of war or national emergency. 21.52 Section 21.52 Public Health PUBLIC HEALTH SERVICE... entrance qualifications for original appointment in time of war or national emergency. If, in time of...

  15. 78 FR 75358 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-11

    ... Committee: National Institute on Aging Special Emphasis Panel; Vitamin D Trials. Date: January 30, 2014...@mail.nih.gov . (Catalogue of Federal Domestic Assistance Program Nos. 93.866, Aging Research,...

  16. 75 FR 9908 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ..., DSC, Scientific Review Officer, Scientific Review Branch, National Institute on Aging, 7201 Wisconsin....) Contact Person: Alicja L Markowska, PhD, DSC, Scientific Review Officer, Scientific Review...

  17. Age Differences in Personality: Evidence from a Nationally Representative Australian Sample

    ERIC Educational Resources Information Center

    Lucas, Richard E.; Donnellan, M. Brent

    2009-01-01

    Cross-sectional age differences in the Big Five personality traits were examined in a nationally representative sample of Australians (N = 12,618; age range = 15-84). Extraversion, Neuroticism, and Openness were negatively associated with age, whereas Agreeableness and Conscientiousness were positively associated with age. Effect sizes comparing…

  18. The sex distribution of suicides by age in nations of the world.

    PubMed

    Lester, D

    1990-03-01

    The ratio of the male suicide rate to the female suicide rate for each age group in 31 nations of the world was found to be associated with the wealth of the nations. The male/female suicide rate ratio was lower in wealthier nations for older adults and higher in wealthier nations for youths. The male/female suicide rate ratio was associated over the nations among the younger age groups and also among the older age groups. These results suggest that the sex ratio may be differently determined in youths and in older adults.

  19. The origin and age of haplochromine fishes in Lake Victoria, east Africa.

    PubMed Central

    Nagl, S; Tichy, H; Mayer, W E; Takezaki, N; Takahata, N; Klein, J

    2000-01-01

    According to a widely held view, the more than 300 species of haplochromine cichlid fishes in Lake Victoria (LV), East Africa, originated from a single founder species in less than 12,000 years. This view, however, does not follow from the published geological and molecular evidence. The former does indeed suggest that the LV basin dried out less than 15,000 years ago, but it does not provide any information about the species that re-colonized the new lake or that remained in the rivers draining the area. The molecular evidence is inconclusive with respect to the origin of the LV haplochromines because cichlids from critical regions around LV were not adequately sampled; and as far as the age of the LV haplochromines is concerned, it in fact led to an estimate of 250,000-750,000 years old. In the present study, mitochondrial DNA (control region) variation was determined by heteroduplex and sequencing analyses of more than 670 specimens collected at widely distributed East African riverine and lacustrine localities. The analyses revealed the existence of seven haplogroups (I-VII) distinguishable by characteristic substitutions. All endemic LV samples tested fell into one of these haplogroups (V) which, however, was also found to be present at various other localities, both riverine and lacustrine, outside LV. Within this haplogroup, four subgroups (VA through VD) could be distinguished, two of which (VB and VC) were represented in LV and at other localities. The great majority of the LV haplochromine species could be classified as belonging to the VC subgroup, which was found only in LV and in the rivers draining into it. Hence, while the endemic haplochromine species of LV could not have originated from a single founding population, the lake does harbour a large species flock which probably arose in situ. PMID:10874756

  20. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

    PubMed

    Perry, John R B; Day, Felix; Elks, Cathy E; Sulem, Patrick; Thompson, Deborah J; Ferreira, Teresa; He, Chunyan; Chasman, Daniel I; Esko, Tõnu; Thorleifsson, Gudmar; Albrecht, Eva; Ang, Wei Q; Corre, Tanguy; Cousminer, Diana L; Feenstra, Bjarke; Franceschini, Nora; Ganna, Andrea; Johnson, Andrew D; Kjellqvist, Sanela; Lunetta, Kathryn L; McMahon, George; Nolte, Ilja M; Paternoster, Lavinia; Porcu, Eleonora; Smith, Albert V; Stolk, Lisette; Teumer, Alexander; Tšernikova, Natalia; Tikkanen, Emmi; Ulivi, Sheila; Wagner, Erin K; Amin, Najaf; Bierut, Laura J; Byrne, Enda M; Hottenga, Jouke-Jan; Koller, Daniel L; Mangino, Massimo; Pers, Tune H; Yerges-Armstrong, Laura M; Hua Zhao, Jing; Andrulis, Irene L; Anton-Culver, Hoda; Atsma, Femke; Bandinelli, Stefania; Beckmann, Matthias W; Benitez, Javier; Blomqvist, Carl; Bojesen, Stig E; Bolla, Manjeet K; Bonanni, Bernardo; Brauch, Hiltrud; Brenner, Hermann; Buring, Julie E; Chang-Claude, Jenny; Chanock, Stephen; Chen, Jinhui; Chenevix-Trench, Georgia; Collée, J Margriet; Couch, Fergus J; Couper, David; Coviello, Andrea D; Cox, Angela; Czene, Kamila; D'adamo, Adamo Pio; Davey Smith, George; De Vivo, Immaculata; Demerath, Ellen W; Dennis, Joe; Devilee, Peter; Dieffenbach, Aida K; Dunning, Alison M; Eiriksdottir, Gudny; Eriksson, Johan G; Fasching, Peter A; Ferrucci, Luigi; Flesch-Janys, Dieter; Flyger, Henrik; Foroud, Tatiana; Franke, Lude; Garcia, Melissa E; García-Closas, Montserrat; Geller, Frank; de Geus, Eco E J; Giles, Graham G; Gudbjartsson, Daniel F; Gudnason, Vilmundur; Guénel, Pascal; Guo, Suiqun; Hall, Per; Hamann, Ute; Haring, Robin; Hartman, Catharina A; Heath, Andrew C; Hofman, Albert; Hooning, Maartje J; Hopper, John L; Hu, Frank B; Hunter, David J; Karasik, David; Kiel, Douglas P; Knight, Julia A; Kosma, Veli-Matti; Kutalik, Zoltan; Lai, Sandra; Lambrechts, Diether; Lindblom, Annika; Mägi, Reedik; Magnusson, Patrik K; Mannermaa, Arto; Martin, Nicholas G; Masson, Gisli; McArdle, Patrick F; McArdle, Wendy L; Melbye, Mads; Michailidou, Kyriaki; Mihailov, Evelin; Milani, Lili; Milne, Roger L; Nevanlinna, Heli; Neven, Patrick; Nohr, Ellen A; Oldehinkel, Albertine J; Oostra, Ben A; Palotie, Aarno; Peacock, Munro; Pedersen, Nancy L; Peterlongo, Paolo; Peto, Julian; Pharoah, Paul D P; Postma, Dirkje S; Pouta, Anneli; Pylkäs, Katri; Radice, Paolo; Ring, Susan; Rivadeneira, Fernando; Robino, Antonietta; Rose, Lynda M; Rudolph, Anja; Salomaa, Veikko; Sanna, Serena; Schlessinger, David; Schmidt, Marjanka K; Southey, Mellissa C; Sovio, Ulla; Stampfer, Meir J; Stöckl, Doris; Storniolo, Anna M; Timpson, Nicholas J; Tyrer, Jonathan; Visser, Jenny A; Vollenweider, Peter; Völzke, Henry; Waeber, Gerard; Waldenberger, Melanie; Wallaschofski, Henri; Wang, Qin; Willemsen, Gonneke; Winqvist, Robert; Wolffenbuttel, Bruce H R; Wright, Margaret J; Boomsma, Dorret I; Econs, Michael J; Khaw, Kay-Tee; Loos, Ruth J F; McCarthy, Mark I; Montgomery, Grant W; Rice, John P; Streeten, Elizabeth A; Thorsteinsdottir, Unnur; van Duijn, Cornelia M; Alizadeh, Behrooz Z; Bergmann, Sven; Boerwinkle, Eric; Boyd, Heather A; Crisponi, Laura; Gasparini, Paolo; Gieger, Christian; Harris, Tamara B; Ingelsson, Erik; Järvelin, Marjo-Riitta; Kraft, Peter; Lawlor, Debbie; Metspalu, Andres; Pennell, Craig E; Ridker, Paul M; Snieder, Harold; Sørensen, Thorkild I A; Spector, Tim D; Strachan, David P; Uitterlinden, André G; Wareham, Nicholas J; Widen, Elisabeth; Zygmunt, Marek; Murray, Anna; Easton, Douglas F; Stefansson, Kari; Murabito, Joanne M; Ong, Ken K

    2014-10-01

    Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust evidence (P < 5 × 10(-8)) for 123 signals at 106 genomic loci associated with age at menarche. Many loci were associated with other pubertal traits in both sexes, and there was substantial overlap with genes implicated in body mass index and various diseases, including rare disorders of puberty. Menarche signals were enriched in imprinted regions, with three loci (DLK1-WDR25, MKRN3-MAGEL2 and KCNK9) demonstrating parent-of-origin-specific associations concordant with known parental expression patterns. Pathway analyses implicated nuclear hormone receptors, particularly retinoic acid and γ-aminobutyric acid-B2 receptor signalling, among novel mechanisms that regulate pubertal timing in humans. Our findings suggest a genetic architecture involving at least hundreds of common variants in the coordinated timing of the pubertal transition. PMID:25231870

  1. Parent-of-origin specific allelic associations among 106 genomic loci for age at menarche

    PubMed Central

    Thompson, Deborah J; Ferreira, Teresa; He, Chunyan; Chasman, Daniel I; Esko, Tõnu; Thorleifsson, Gudmar; Albrecht, Eva; Ang, Wei Q; Corre, Tanguy; Cousminer, Diana L; Feenstra, Bjarke; Franceschini, Nora; Ganna, Andrea; Johnson, Andrew D; Kjellqvist, Sanela; Lunetta, Kathryn L; McMahon, George; Nolte, Ilja M; Paternoster, Lavinia; Porcu, Eleonora; Smith, Albert V; Stolk, Lisette; Teumer, Alexander; Tšernikova, Natalia; Tikkanen, Emmi; Ulivi, Sheila; Wagner, Erin K; Amin, Najaf; Bierut, Laura J; Byrne, Enda M; Hottenga, Jouke-Jan; Koller, Daniel L; Mangino, Massimo; Pers, Tune H; Yerges-Armstrong, Laura M; Zhao, Jing Hua; Andrulis, Irene L; Anton-Culver, Hoda; Atsma, Femke; Bandinelli, Stefania; Beckmann, Matthias W; Benitez, Javier; Blomqvist, Carl; Bojesen, Stig E; Bolla, Manjeet K; Bonanni, Bernardo; Brauch, Hiltrud; Brenner, Hermann; Buring, Julie E; Chang-Claude, Jenny; Chanock, Stephen; Chen, Jinhui; Chenevix-Trench, Georgia; Collée, J. Margriet; Couch, Fergus J; Couper, David; Coveillo, Andrea D; Cox, Angela; Czene, Kamila; D’adamo, Adamo Pio; Smith, George Davey; De Vivo, Immaculata; Demerath, Ellen W; Dennis, Joe; Devilee, Peter; Dieffenbach, Aida K; Dunning, Alison M; Eiriksdottir, Gudny; Eriksson, Johan G; Fasching, Peter A; Ferrucci, Luigi; Flesch-Janys, Dieter; Flyger, Henrik; Foroud, Tatiana; Franke, Lude; Garcia, Melissa E; García-Closas, Montserrat; Geller, Frank; de Geus, Eco EJ; Giles, Graham G; Gudbjartsson, Daniel F; Gudnason, Vilmundur; Guénel, Pascal; Guo, Suiqun; Hall, Per; Hamann, Ute; Haring, Robin; Hartman, Catharina A; Heath, Andrew C; Hofman, Albert; Hooning, Maartje J; Hopper, John L; Hu, Frank B; Hunter, David J; Karasik, David; Kiel, Douglas P; Knight, Julia A; Kosma, Veli-Matti; Kutalik, Zoltan; Lai, Sandra; Lambrechts, Diether; Lindblom, Annika; Mägi, Reedik; Magnusson, Patrik K; Mannermaa, Arto; Martin, Nicholas G; Masson, Gisli; McArdle, Patrick F; McArdle, Wendy L; Melbye, Mads; Michailidou, Kyriaki; Mihailov, Evelin; Milani, Lili; Milne, Roger L; Nevanlinna, Heli; Neven, Patrick; Nohr, Ellen A; Oldehinkel, Albertine J; Oostra, Ben A; Palotie, Aarno; Peacock, Munro; Pedersen, Nancy L; Peterlongo, Paolo; Peto, Julian; Pharoah, Paul DP; Postma, Dirkje S; Pouta, Anneli; Pylkäs, Katri; Radice, Paolo; Ring, Susan; Rivadeneira, Fernando; Robino, Antonietta; Rose, Lynda M; Rudolph, Anja; Salomaa, Veikko; Sanna, Serena; Schlessinger, David; Schmidt, Marjanka K; Southey, Mellissa C; Sovio, Ulla; Stampfer, Meir J; Stöckl, Doris; Storniolo, Anna M; Timpson, Nicholas J; Tyrer, Jonathan; Visser, Jenny A; Vollenweider, Peter; Völzke, Henry; Waeber, Gerard; Waldenberger, Melanie; Wallaschofski, Henri; Wang, Qin; Willemsen, Gonneke; Winqvist, Robert; Wolffenbuttel, Bruce HR; Wright, Margaret J; Boomsma, Dorret I; Econs, Michael J; Khaw, Kay-Tee; Loos, Ruth JF; McCarthy, Mark I; Montgomery, Grant W; Rice, John P; Streeten, Elizabeth A; Thorsteinsdottir, Unnur; van Duijn, Cornelia M; Alizadeh, Behrooz Z; Bergmann, Sven; Boerwinkle, Eric; Boyd, Heather A; Crisponi, Laura; Gasparini, Paolo; Gieger, Christian; Harris, Tamara B; Ingelsson, Erik; Järvelin, Marjo-Riitta; Kraft, Peter; Lawlor, Debbie; Metspalu, Andres; Pennell, Craig E; Ridker, Paul M; Snieder, Harold; Sørensen, Thorkild IA; Spector, Tim D; Strachan, David P; Uitterlinden, André G; Wareham, Nicholas J; Widen, Elisabeth; Zygmunt, Marek; Murray, Anna; Easton, Douglas F

    2014-01-01

    Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality1. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation2,3, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust evidence (P<5×10−8) for 123 signals at 106 genomic loci associated with age at menarche. Many loci were associated with other pubertal traits in both sexes, and there was substantial overlap with genes implicated in body mass index and various diseases, including rare disorders of puberty. Menarche signals were enriched in imprinted regions, with three loci (DLK1/WDR25, MKRN3/MAGEL2 and KCNK9) demonstrating parent-of-origin specific associations concordant with known parental expression patterns. Pathway analyses implicated nuclear hormone receptors, particularly retinoic acid and gamma-aminobutyric acid-B2 receptor signaling, among novel mechanisms that regulate pubertal timing in humans. Our findings suggest a genetic architecture involving at least hundreds of common variants in the coordinated timing of the pubertal transition. PMID:25231870

  2. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

    PubMed

    Perry, John R B; Day, Felix; Elks, Cathy E; Sulem, Patrick; Thompson, Deborah J; Ferreira, Teresa; He, Chunyan; Chasman, Daniel I; Esko, Tõnu; Thorleifsson, Gudmar; Albrecht, Eva; Ang, Wei Q; Corre, Tanguy; Cousminer, Diana L; Feenstra, Bjarke; Franceschini, Nora; Ganna, Andrea; Johnson, Andrew D; Kjellqvist, Sanela; Lunetta, Kathryn L; McMahon, George; Nolte, Ilja M; Paternoster, Lavinia; Porcu, Eleonora; Smith, Albert V; Stolk, Lisette; Teumer, Alexander; Tšernikova, Natalia; Tikkanen, Emmi; Ulivi, Sheila; Wagner, Erin K; Amin, Najaf; Bierut, Laura J; Byrne, Enda M; Hottenga, Jouke-Jan; Koller, Daniel L; Mangino, Massimo; Pers, Tune H; Yerges-Armstrong, Laura M; Hua Zhao, Jing; Andrulis, Irene L; Anton-Culver, Hoda; Atsma, Femke; Bandinelli, Stefania; Beckmann, Matthias W; Benitez, Javier; Blomqvist, Carl; Bojesen, Stig E; Bolla, Manjeet K; Bonanni, Bernardo; Brauch, Hiltrud; Brenner, Hermann; Buring, Julie E; Chang-Claude, Jenny; Chanock, Stephen; Chen, Jinhui; Chenevix-Trench, Georgia; Collée, J Margriet; Couch, Fergus J; Couper, David; Coviello, Andrea D; Cox, Angela; Czene, Kamila; D'adamo, Adamo Pio; Davey Smith, George; De Vivo, Immaculata; Demerath, Ellen W; Dennis, Joe; Devilee, Peter; Dieffenbach, Aida K; Dunning, Alison M; Eiriksdottir, Gudny; Eriksson, Johan G; Fasching, Peter A; Ferrucci, Luigi; Flesch-Janys, Dieter; Flyger, Henrik; Foroud, Tatiana; Franke, Lude; Garcia, Melissa E; García-Closas, Montserrat; Geller, Frank; de Geus, Eco E J; Giles, Graham G; Gudbjartsson, Daniel F; Gudnason, Vilmundur; Guénel, Pascal; Guo, Suiqun; Hall, Per; Hamann, Ute; Haring, Robin; Hartman, Catharina A; Heath, Andrew C; Hofman, Albert; Hooning, Maartje J; Hopper, John L; Hu, Frank B; Hunter, David J; Karasik, David; Kiel, Douglas P; Knight, Julia A; Kosma, Veli-Matti; Kutalik, Zoltan; Lai, Sandra; Lambrechts, Diether; Lindblom, Annika; Mägi, Reedik; Magnusson, Patrik K; Mannermaa, Arto; Martin, Nicholas G; Masson, Gisli; McArdle, Patrick F; McArdle, Wendy L; Melbye, Mads; Michailidou, Kyriaki; Mihailov, Evelin; Milani, Lili; Milne, Roger L; Nevanlinna, Heli; Neven, Patrick; Nohr, Ellen A; Oldehinkel, Albertine J; Oostra, Ben A; Palotie, Aarno; Peacock, Munro; Pedersen, Nancy L; Peterlongo, Paolo; Peto, Julian; Pharoah, Paul D P; Postma, Dirkje S; Pouta, Anneli; Pylkäs, Katri; Radice, Paolo; Ring, Susan; Rivadeneira, Fernando; Robino, Antonietta; Rose, Lynda M; Rudolph, Anja; Salomaa, Veikko; Sanna, Serena; Schlessinger, David; Schmidt, Marjanka K; Southey, Mellissa C; Sovio, Ulla; Stampfer, Meir J; Stöckl, Doris; Storniolo, Anna M; Timpson, Nicholas J; Tyrer, Jonathan; Visser, Jenny A; Vollenweider, Peter; Völzke, Henry; Waeber, Gerard; Waldenberger, Melanie; Wallaschofski, Henri; Wang, Qin; Willemsen, Gonneke; Winqvist, Robert; Wolffenbuttel, Bruce H R; Wright, Margaret J; Boomsma, Dorret I; Econs, Michael J; Khaw, Kay-Tee; Loos, Ruth J F; McCarthy, Mark I; Montgomery, Grant W; Rice, John P; Streeten, Elizabeth A; Thorsteinsdottir, Unnur; van Duijn, Cornelia M; Alizadeh, Behrooz Z; Bergmann, Sven; Boerwinkle, Eric; Boyd, Heather A; Crisponi, Laura; Gasparini, Paolo; Gieger, Christian; Harris, Tamara B; Ingelsson, Erik; Järvelin, Marjo-Riitta; Kraft, Peter; Lawlor, Debbie; Metspalu, Andres; Pennell, Craig E; Ridker, Paul M; Snieder, Harold; Sørensen, Thorkild I A; Spector, Tim D; Strachan, David P; Uitterlinden, André G; Wareham, Nicholas J; Widen, Elisabeth; Zygmunt, Marek; Murray, Anna; Easton, Douglas F; Stefansson, Kari; Murabito, Joanne M; Ong, Ken K

    2014-10-01

    Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust evidence (P < 5 × 10(-8)) for 123 signals at 106 genomic loci associated with age at menarche. Many loci were associated with other pubertal traits in both sexes, and there was substantial overlap with genes implicated in body mass index and various diseases, including rare disorders of puberty. Menarche signals were enriched in imprinted regions, with three loci (DLK1-WDR25, MKRN3-MAGEL2 and KCNK9) demonstrating parent-of-origin-specific associations concordant with known parental expression patterns. Pathway analyses implicated nuclear hormone receptors, particularly retinoic acid and γ-aminobutyric acid-B2 receptor signalling, among novel mechanisms that regulate pubertal timing in humans. Our findings suggest a genetic architecture involving at least hundreds of common variants in the coordinated timing of the pubertal transition.

  3. The origin of the Canary Island Seamount Province - new ages of old seamounts.

    PubMed

    van den Bogaard, Paul

    2013-01-01

    The Canary Island Seamount Province forms a scattered hotspot track on the Atlantic ocean floor ~1300 km long and ~350 km wide, perpendicular to lithospheric fractures, and parallel to the NW African continental margin. New (40)Ar/(39)Ar datings show that seamount ages vary from 133 Ma to 0.2 Ma in the central archipelago, and from 142 Ma to 91 Ma in the southwest. Combining (40)Ar/(39)Ar ages with plate tectonic reconstructions, I find that the temporal and spatial distribution of seamounts is irreconcilable with a deep fixed mantle plume origin, or derivation from passive mantle upwelling beneath a mid-ocean ridge. I conclude that shallow mantle upwelling beneath the Atlantic Ocean basin off the NW African continental lithosphere flanks produced recurrent melting anomalies and seamounts from the Late Jurassic to Recent, nominating the Canary Island Seamount Province as oldest hotspot track in the Atlantic Ocean, and most long-lived preserved on earth. PMID:23838703

  4. The origin of the Canary Island Seamount Province - new ages of old seamounts.

    PubMed

    van den Bogaard, Paul

    2013-01-01

    The Canary Island Seamount Province forms a scattered hotspot track on the Atlantic ocean floor ~1300 km long and ~350 km wide, perpendicular to lithospheric fractures, and parallel to the NW African continental margin. New (40)Ar/(39)Ar datings show that seamount ages vary from 133 Ma to 0.2 Ma in the central archipelago, and from 142 Ma to 91 Ma in the southwest. Combining (40)Ar/(39)Ar ages with plate tectonic reconstructions, I find that the temporal and spatial distribution of seamounts is irreconcilable with a deep fixed mantle plume origin, or derivation from passive mantle upwelling beneath a mid-ocean ridge. I conclude that shallow mantle upwelling beneath the Atlantic Ocean basin off the NW African continental lithosphere flanks produced recurrent melting anomalies and seamounts from the Late Jurassic to Recent, nominating the Canary Island Seamount Province as oldest hotspot track in the Atlantic Ocean, and most long-lived preserved on earth.

  5. The origin of the Canary Island Seamount Province - New ages of old seamounts

    PubMed Central

    van den Bogaard, Paul

    2013-01-01

    The Canary Island Seamount Province forms a scattered hotspot track on the Atlantic ocean floor ~1300 km long and ~350 km wide, perpendicular to lithospheric fractures, and parallel to the NW African continental margin. New 40Ar/39Ar datings show that seamount ages vary from 133 Ma to 0.2 Ma in the central archipelago, and from 142 Ma to 91 Ma in the southwest. Combining 40Ar/39Ar ages with plate tectonic reconstructions, I find that the temporal and spatial distribution of seamounts is irreconcilable with a deep fixed mantle plume origin, or derivation from passive mantle upwelling beneath a mid-ocean ridge. I conclude that shallow mantle upwelling beneath the Atlantic Ocean basin off the NW African continental lithosphere flanks produced recurrent melting anomalies and seamounts from the Late Jurassic to Recent, nominating the Canary Island Seamount Province as oldest hotspot track in the Atlantic Ocean, and most long-lived preserved on earth. PMID:23838703

  6. Age and origin of the Gezira alluvial fan between the Blue and White Nile rivers

    NASA Astrophysics Data System (ADS)

    Williams, martin

    2014-05-01

    The Gezira is a low-angle alluvial fan bounded by the Blue Nile to the east and the White Nile to the west. It is the main agricultural region of Sudan and produces high quality long-staple cotton for export. Dark cracking clays (vertisols) cover much of the Gezira and range in age from 50 kyr to Holocene. The Gezira is traversed by a series of defunct sandy channels that originate between Sennar and Wad Medani on the present-day Blue Nile. With a radius of 300 km and an area of 40,000 km2 the Gezira is a mega-fan. The younger channels range in age from early Holocene to 100 kyr, while near surface channels filled with rolled quartz and carbonate gravels have ages back to >250 kyr. Boreholes in the Gezira reveal coarse alluvial sands and gravels in now buried channels overlain by alluvial clays, forming a repetitive sequence of fining-upwards alluvial units. that probably extend back to Pliocene times. The fan is up to 180 m thick with a volume of ~1,800 km3. The sandy or gravelly bed-load channels coincide with colder drier climates and sparse vegetation in the Ethiopian headwaters of the Blue Nile and the alluvial clays denote widespread flooding during times of stronger summer monsoon. The early stages of such flood events were often accompanied by mass burial of Nile oyster (Etheria elliptica) beds, such as the 45-50 kyr floods that deposited up to 5 m of clay in the northern Gezira. A unique feature of the eastern Gezira is a former Blue Nile channel at least 80 km long running parallel to the present river and entirely filled with volcanic ash. The channel was only 3-4 m deep and 20-30 m wide. Very fine laminations and cross-beds, together with locally abundant phytoliths and sponge spicules, suggest slow-moving water, with flow dispersed across many distributary channels. The ash geochemistry is similar to that in the lower part of the Kibish Formation in the lower Omo valley of southern Ethiopia and points to a minimum age of 100 kyr and a maximum age of

  7. The National Biological Information Infrastructure: Coming of Age.

    ERIC Educational Resources Information Center

    Cotter, Gladys; Frame, Mike; Sepic, Ron; Zolly, Lisa

    2000-01-01

    Coordinated by the U.S. Geological Survey, the National Biological Information Infrastructure (NBII) is a Web-based system that provides increased access to data and information on the nation's biological resources. This article-an individual case study-addresses the structure of the NBII related to thematic, infrastructure and place-based…

  8. Activity and recovery profiles of state-of-origin and national rugby league match-play.

    PubMed

    Gabbett, Tim J

    2015-03-01

    State-of-Origin is the highest standard of rugby league competition played anywhere in the world. This study investigated the activity profiles of State-of-Origin and compared them against regular National Rugby League (NRL) fixture matches. Video footage from State-of-Origin and NRL matches were coded for activity and recovery cycles. Time when the ball was continuously in play was considered activity, whereas any stoppages during matches were considered recovery. Ball-in-play periods in matches of different playing standards were analyzed by comparing State-of-Origin matches, NRL matches (with representative players available), and NRL matches (with representative players unavailable). The mean, maximum, and total ball-in-play time of State-of-Origin matches were longer than NRL matches (effect size [ES] ≥ 0.75) with and without the availability of representative players. State-of-Origin matches were associated with a greater proportion (ES ≥ 1.54) of long duration (46-300 seconds) ball-in-play periods, and a smaller proportion (ES ≥ 1.69) of short duration (<45 seconds) ball-in-play periods than NRL matches when representative players were both available and unavailable for selection. When representative players were available for club selection, NRL matches were associated with a smaller proportion of short duration ball-in-play periods (ES = 1.14) and a larger proportion of long duration ball-in-play periods (ES = 0.89), compared with NRL matches when representative players were unavailable. The results of this study provide empirical support for the higher playing intensity of State-of-Origin matches in comparison with regular NRL fixture matches. Furthermore, these findings demonstrate the lower quality of NRL matches during the State-of-Origin period, when representative players are unavailable for selection for their club team. From a practical perspective, these results quantify the difference in activity profiles between State-of-Origin and NRL

  9. The Role of Social Relationships in Predicting Loneliness: The National Social Life, Health, and Aging Project

    ERIC Educational Resources Information Center

    Shiovitz-Ezra, Sharon; Leitsch, Sara A.

    2010-01-01

    The authors explore associations between objective and subjective social network characteristics and loneliness in later life, using data from the National Social Life, Health, and Aging Project, a nationally representative sample of individuals ages 57 to 85 in the United States. Hierarchical linear regression was used to examine the associations…

  10. 78 FR 28237 - National Institute on Aging; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-14

    ... Beach, CA 90802, which was published in the Federal Register on May 3, 2013, 78 FR 26054. The dates of... HUMAN SERVICES National Institutes of Health National Institute on Aging; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the Clinical Aging Review Committee, June 12,...

  11. 78 FR 21960 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-12

    ... Committee: National Institute on Aging Special Emphasis Panel; Presenilins and Alzheimer's Disease. Date..., PARSADANIANA@NIA.NIH.GOV . Name of Committee: National Institute on Aging Special Emphasis Panel; Alzheimer's... Special Emphasis Panel; Alzheimer's Disease Prevention. Date: July 11, 2013. Time: 12 p.m. to 1...

  12. Age, origins and extinctions of the avifauna of Macaronesia: a synthesis of phylogenetic and fossil information

    NASA Astrophysics Data System (ADS)

    Illera, Juan Carlos; Rando, Juan Carlos; Richardson, David S.; Emerson, Brent C.

    2012-09-01

    Understanding the age, origins and extinction of oceanic island biota has captivated the interest of evolutionary biologists since Darwin and Wallace. Because oceanic islands are discrete entities of small geographical size but with considerable habitat diversity, they provide ideal templates within which to study evolutionary processes. The peripheral North Atlantic islands, collectively referred to as Macaronesia, are considered a hot spot of biodiversity due to the fact that they contain a large proportion of endemic taxa (ca 25%). Recent molecular studies are providing insight into the patterns of colonization and radiation within the extant avifauna, while paleontological studies have described many extinct avian species, sometimes identifying the causes and chronology of extinction. The aim of this review is to develop an understanding of the evolutionary and biogeographic history of the macaronesian avifauna, combining information from phylogenetic and paleontological studies. We then compare patterns for Macaronesia with those of other oceanic archipelagos to evaluate to what extent patterns may be generalised across regions. Phylogenetic analyses have confirmed the close relationships between endemic macaronesian avifauna and the closest mainland areas (Europe and Africa), however, in contrast to other archipelagos of a similar age, we show that most extant birds appear to have colonized macaronesian archipelagos relatively recently, within the last four million years, despite some islands being approximately 30 million years old. Fossil records support the idea that higher species richness previously existed, with recent dating on bone collagen of selected extinct species suggesting that their extinction coincided with the arrival of aboriginal people ca 2500 years ago in the Canary Islands, or the arrival of Europeans across all the macaronesian islands in the 14th century. It is plausible that these human mediated extinctions may have selectively acted

  13. 78 FR 70310 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings..., National Institutes of Health, HHS). Dated: November 19, 2013. Melanie J. Gray, Program Analyst, Office...

  14. 78 FR 67177 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting..., National Institutes of Health, 7201 Wisconsin Avenue, Suite 2c-212, Bethesda, MD 20892, 301-402-7700,...

  15. Genetic evidence for an origin of the Armenians from Bronze Age mixing of multiple populations

    PubMed Central

    Haber, Marc; Mezzavilla, Massimo; Xue, Yali; Comas, David; Gasparini, Paolo; Zalloua, Pierre; Tyler-Smith, Chris

    2016-01-01

    The Armenians are a culturally isolated population who historically inhabited a region in the Near East bounded by the Mediterranean and Black seas and the Caucasus, but remain under-represented in genetic studies and have a complex history including a major geographic displacement during World War I. Here, we analyse genome-wide variation in 173 Armenians and compare them with 78 other worldwide populations. We find that Armenians form a distinctive cluster linking the Near East, Europe, and the Caucasus. We show that Armenian diversity can be explained by several mixtures of Eurasian populations that occurred between ~3000 and ~2000 bce, a period characterized by major population migrations after the domestication of the horse, appearance of chariots, and the rise of advanced civilizations in the Near East. However, genetic signals of population mixture cease after ~1200 bce when Bronze Age civilizations in the Eastern Mediterranean world suddenly and violently collapsed. Armenians have since remained isolated and genetic structure within the population developed ~500 years ago when Armenia was divided between the Ottomans and the Safavid Empire in Iran. Finally, we show that Armenians have higher genetic affinity to Neolithic Europeans than other present-day Near Easterners, and that 29% of Armenian ancestry may originate from an ancestral population that is best represented by Neolithic Europeans. PMID:26486470

  16. Genetic evidence for an origin of the Armenians from Bronze Age mixing of multiple populations.

    PubMed

    Haber, Marc; Mezzavilla, Massimo; Xue, Yali; Comas, David; Gasparini, Paolo; Zalloua, Pierre; Tyler-Smith, Chris

    2016-06-01

    The Armenians are a culturally isolated population who historically inhabited a region in the Near East bounded by the Mediterranean and Black seas and the Caucasus, but remain under-represented in genetic studies and have a complex history including a major geographic displacement during World War I. Here, we analyse genome-wide variation in 173 Armenians and compare them with 78 other worldwide populations. We find that Armenians form a distinctive cluster linking the Near East, Europe, and the Caucasus. We show that Armenian diversity can be explained by several mixtures of Eurasian populations that occurred between ~3000 and ~2000 bce, a period characterized by major population migrations after the domestication of the horse, appearance of chariots, and the rise of advanced civilizations in the Near East. However, genetic signals of population mixture cease after ~1200 bce when Bronze Age civilizations in the Eastern Mediterranean world suddenly and violently collapsed. Armenians have since remained isolated and genetic structure within the population developed ~500 years ago when Armenia was divided between the Ottomans and the Safavid Empire in Iran. Finally, we show that Armenians have higher genetic affinity to Neolithic Europeans than other present-day Near Easterners, and that 29% of Armenian ancestry may originate from an ancestral population that is best represented by Neolithic Europeans. PMID:26486470

  17. Age at Puberty and Father Absence in a National Probability Sample

    ERIC Educational Resources Information Center

    Bogaert, A.F.

    2005-01-01

    The relations between intactness of the parental unit (e.g., father absent at age 14) and pubertal timing in both men and women were examined in a US national probability sample. In both men and women, an absent father at age 14 predicted an earlier age of puberty (e.g., early menarche or voice change). There was little evidence that an absent…

  18. Years of potential life lost before age 65, by race, Hispanic origin, and sex--United States, 1986-1988.

    PubMed

    Desenclos, J C; Hahn, R A

    1992-11-20

    A substantial proportion of mortality among young persons is preventable. National vital statistics were used to establish a baseline for the surveillance of rates of years of potential life lost before age 65 (YPLL < 65) in the United States. Rates of YPLL < 65 were calculated for 1986 through 1988 for leading causes of preventable death, by race, Hispanic origin, and sex. U.S. racial and ethnic populations differed widely in YPLL < 65. Among males, the rate (per 1,000 population < 65 years) of YPLL < 65 was highest for non-Hispanic blacks (140.0), followed by American Indians/Alaskan Natives (100.9), Hispanics (74.3), non-Hispanic whites (68.3), and Asians/Pacific Islanders (38.2). Among females, the rate was highest for non-Hispanic blacks (73.7), followed by American Indians/Alaskan Natives (52.0), non-Hispanic whites (35.7), Hispanics (32.9), and Asians/Pacific Islanders (23.2). For non-Hispanic blacks, the high rate of YPLL < 65 was due to increased rates for all causes of death considered, particularly homicide. The high rate for American Indians/Alaskan Natives was due principally to deaths from four causes: unintentional injuries, cirrhosis, suicide, and diabetes. Asians/Pacific Islanders had low rates for most causes of death. In setting health-care priorities and prevention strategies to reduce the large racial-ethnic gap in early deaths, it is essential to recognize the differences in causes of premature mortality among sex, racial, and ethnic populations. Periodic reassessment of YPLL < 65 among these groups provides a simple, timely, and representative means of conducting surveillance to measure the impact of intervention strategies on a national basis.

  19. DOE-sponsored cable aging research at Sandia National Laboratories

    SciTech Connect

    Gillen, K.T.; Clough, R.L.; Celina, M.; Wise, J.; Malone, G.M.

    1995-12-01

    Cables have been identified as critical components requiring detailed technical evaluation for extending the lifetime of Light Water Reactors beyond 40 years. This paper highlights some of the DOE-sponsored cable aging studies currently underway at Sandia. These studies are focused on two important issues: the validity of the often-used Arrhenius thermal aging prediction method and methods for predicting lifetimes in combined thermal-radiation environments. Accelerated thermal aging results are presented for three cable jacket and insulation materials, which indicate that hardening of the outside surface has an Arrhenius temperature dependence and correlates well with reductions in ultimate tensile elongation. This suggests that the indentor approach is a promising NDE technique for cable jacket and unjacketed insulation materials installed in thermally-dominated regions of nuclear power plants.

  20. The National Biological Information Infrastructure: Coming of age

    USGS Publications Warehouse

    Cotter, G.; Frame, M.; Sepic, R.; Zolly, L.

    2000-01-01

    Coordinated by the US Geological Survey, the National Biological Information Infrastructure (NBII) is a Web-based system that provides increased access to data and information on the nation's biological resources. The NBII can be viewed from a variety of perspectives. This article - an individual case study and not a broad survey with extensive references to the literature - addresses the structure of the NBII related to thematic sections, infrastructure sections and place-based sections, and other topics such as the Integrated Taxonomic Information System (one of our more innovative tools) and the development of our controlled vocabulary.

  1. Health Care Access and Utilization Among Adults Aged 18-64, by Race and Hispanic Origin: United States, 2013 and 2014.

    PubMed

    Martinez, Michael E; Ward, Brian W; Adams, Patricia F

    2015-07-01

    In 2014, U.S. adults could buy a private health insurance plan through the Health Insurance Marketplace or state-based exchanges established as part of the Affordable Care Act. Moreover, some states opted to expand Medicaid coverage to low-income adults. Data from the 2013 and 2014 National Health Interview Survey (NHIS) are used to describe recent changes in health insurance coverage and selected measures of health care access and utilization for adults aged 18–64, by race and Hispanic origin.

  2. Unmarried Boomers Confront Old Age: A National Portrait

    ERIC Educational Resources Information Center

    Lin, I-Fen; Brown, Susan L.

    2012-01-01

    Purpose of the Study: Our study provides a national portrait of the Baby Boom generation, paying particular attention to the heterogeneity among unmarried Boomers and whether it operates similarly among women versus men. Design and Methods: We used the 1980, 1990, and 2000 Census 5% samples and the 2009 American Community Survey (ACS) to document…

  3. A NATIONAL AGENDA ON THE ENVIRONMENT AND THE AGING

    EPA Science Inventory

    By 2030, the number of older Americans is expected to double to 70 million largely as a result of the aging of the baby boomers. The rapid growth in the number of older Americans has many public health implications, including the need to better understand the potential risks p...

  4. The Nation's Liberal Arts Colleges in an Age of Universities.

    ERIC Educational Resources Information Center

    Zemsky, Robert, Ed.

    1995-01-01

    This theme issue of "Policy Perspectives" examines the role and survivability of liberal arts colleges in an age of universities. The lead essay, "Cross Currents," emphasizes that the liberal arts college embodies the ideal form of scholarly purpose and endeavor in undergraduate institutions, that the gap between the values inherent in a liberal…

  5. The Origins of Mental Toughness – Prosocial Behavior and Low Internalizing and Externalizing Problems at Age 5 Predict Higher Mental Toughness Scores at Age 14

    PubMed Central

    Sadeghi Bahmani, Dena; Hatzinger, Martin; Gerber, Markus; Lemola, Sakari; Clough, Peter J.; Perren, Sonja; von Klitzing, Kay; von Wyl, Agnes; Holsboer-Trachsler, Edith; Brand, Serge

    2016-01-01

    Background: The concept of mental toughness (MT) has gained increasing importance among groups other than elite athletes by virtue of its psychological importance and explanatory power for a broad range of health-related behaviors. However, no study has focused so far on the psychological origins of MT. Therefore, the aims of the present study were: to explore, to what extent the psychological profiles of preschoolers aged five were associated with both (1) MT scores and (2) sleep disturbances at age 14, and 3) to explore possible gender differences. Method: Nine years after their first assessment at age five (preschoolers), a total of 77 adolescents (mean age: 14.35 years; SD = 1.22; 42% females) took part in this follow-up study. At baseline, both parents and teachers completed the Strengths and Difficulties Questionnaire (SDQ), covering internalizing and externalizing problems, hyperactivity, negative peer relationships, and prosocial behavior. At follow-up, participants completed a booklet of questionnaires covering socio-demographic data, MT, and sleep disturbances. Results: Higher prosocial behavior, lower negative peer relationships, and lower internalizing and externalizing problems at age five, as rated by parents and teachers, were associated with self-reported higher MT and lower sleep disturbances at age 14. At age 14, and relative to males, females had lower MT scores and reported more sleep disturbances. Conclusion: The pattern of results suggests that MT traits during adolescence may have their origins in the pre-school years. PMID:27605919

  6. The Origins of Mental Toughness – Prosocial Behavior and Low Internalizing and Externalizing Problems at Age 5 Predict Higher Mental Toughness Scores at Age 14

    PubMed Central

    Sadeghi Bahmani, Dena; Hatzinger, Martin; Gerber, Markus; Lemola, Sakari; Clough, Peter J.; Perren, Sonja; von Klitzing, Kay; von Wyl, Agnes; Holsboer-Trachsler, Edith; Brand, Serge

    2016-01-01

    Background: The concept of mental toughness (MT) has gained increasing importance among groups other than elite athletes by virtue of its psychological importance and explanatory power for a broad range of health-related behaviors. However, no study has focused so far on the psychological origins of MT. Therefore, the aims of the present study were: to explore, to what extent the psychological profiles of preschoolers aged five were associated with both (1) MT scores and (2) sleep disturbances at age 14, and 3) to explore possible gender differences. Method: Nine years after their first assessment at age five (preschoolers), a total of 77 adolescents (mean age: 14.35 years; SD = 1.22; 42% females) took part in this follow-up study. At baseline, both parents and teachers completed the Strengths and Difficulties Questionnaire (SDQ), covering internalizing and externalizing problems, hyperactivity, negative peer relationships, and prosocial behavior. At follow-up, participants completed a booklet of questionnaires covering socio-demographic data, MT, and sleep disturbances. Results: Higher prosocial behavior, lower negative peer relationships, and lower internalizing and externalizing problems at age five, as rated by parents and teachers, were associated with self-reported higher MT and lower sleep disturbances at age 14. At age 14, and relative to males, females had lower MT scores and reported more sleep disturbances. Conclusion: The pattern of results suggests that MT traits during adolescence may have their origins in the pre-school years.

  7. The Origin of Aging: Imperfectness-Driven Non-Random Damage Defines the Aging Process and Control of Lifespan

    PubMed Central

    Gladyshev, Vadim N.

    2013-01-01

    Physico-chemical properties preclude ideal biomolecules and perfect biological functions. This inherent imperfectness leads to the generation of damage by every biological process, at all levels, from small molecules to cells. The damage is too numerous to be repaired, is partially invisible to natural selection and manifests as aging. I propose that it is the inherent imperfectness of biological systems that is the true root of the aging process. As each biomolecule generates specific forms of damage, the cumulative damage is largely non-random and is indirectly encoded in the genome. I consider this concept in light of other proposed theories of aging and integrate these disparate ideas into a single model. I also discuss the evolutionary significance of damage accumulation and strategies for reducing damage. Finally, I suggest ways to test this integrated model of aging. PMID:23769208

  8. Kukersite--An oil shale of Ordovician age: Origin, occurrence, and geochemistry

    SciTech Connect

    Bauert, H. . Geology Dept.)

    1992-01-01

    Kukersite is the name originally given to Ordovician oil shale in the Baltic oil shale basin of Estonia. This basin covers about 50,000 sq km and extends eastward to the Leningrad district of Russia. The main oil shale sequence contains up to 50 kukersite beds alternating with argillaceous limestone. They accumulated in Llandeilo-early Caradoc (early Middle Ordovician) during a prominent regression of the Baltoscandian epicontinental sea. This oil shale contains up to 50--60% of total organic carbon. Kukersite consists mostly of accumulations of the microfossil Gloeocapsomorpha prisca, which was apparently an intertidal to very shallow subtidal, marine, mat-forming, benthonic cyanobacterium. Morphological and biogeochemical characteristics show strong similarities with modern mat-forming cyanobacterium Entophysalis major, which can be regarded as a modern analogue for G. prisca. Beside Estonia, the kukersite-type oil shales are known from several sedimentary basins in North America (in Michigan, Illinois, Wisconsin, North Dakota, Oklahoma) and in Australia (Amadeus and Canning basins), and all of these are exclusively of Ordovician age. G. prisca-dominated oil shales have a high hydrocarbon yield and are considered the main source for Ordovician oils in the USA. Hydrocarbons generated from kukersites have certain distinctive geochemical characteristics. These oils have the characteristic predominance of odd carbon number (C[sub 13]-C[sub 19]) n-alkanes with virtual absence of pristane and phytane. The worldwide distribution of kukersites and the related oils points to the fact that shallow-water widespread Ordovician cratonic seas were a favorable environment for C. prisca.

  9. Evolutionary Asiacentrism, Peking man, and the origins of sinocentric ethno-nationalism.

    PubMed

    Yen, Hsiao-Pei

    2014-01-01

    This paper discusses how the theory of evolutionary Asiacentrism and the Peking Man findings at the Zhoukoudian site stimulated Chinese intellectuals to construct Sinocentric ethno-nationalism during the period from the late 1920s to the early 1940s. It shows that the theory was first popularized by foreign scientists in Beijing, and the Peking man discoveries further provided strong evidence for the idea that Central Asia, or to be more specific, Tibet, Xinjiang, and Mongolia, was the original cradle of humans. Chinese scholars in the late 1930s and 1940s appropriated the findings to construct the monogenesis theory of the Chinese, which designated that all the diverse ethnic groups within the territory of China shared a common ancestor back to antiquity. PMID:24771020

  10. A Comparative Perspective on Intermarriage: Explaining Differences Among National-Origin Groups in the United States

    PubMed Central

    KALMIJN, MATTHIJS; VAN TUBERGEN, FRANK

    2010-01-01

    Little is known about the validity of group-level theories of ethnic intermarriage despite the fact that such theories are often invoked in explaining why certain ethnic groups are “closed,” whereas others are relatively “open.” We develop a comparative perspective by analyzing the marriage choices of 94 national-origin groups in the United States, using pooled data from the Current Population Surveys, 1994–2006, and multilevel models in which individual and contextual determinants of intermarriage are included simultaneously. Our analyses show large differences in endogamy across groups. After taking compositional effects into account, we find that both structural and cultural group-level factors have significant effects on endogamy. Cultural explanations (which focus on the role of norms and preferences) play a more important role than structural explanations (which focus on meeting and mating opportunities). Our results reinforce the common but untested interpretation of endogamy in terms of group boundaries. PMID:20608106

  11. Evolutionary Asiacentrism, Peking man, and the origins of sinocentric ethno-nationalism.

    PubMed

    Yen, Hsiao-Pei

    2014-01-01

    This paper discusses how the theory of evolutionary Asiacentrism and the Peking Man findings at the Zhoukoudian site stimulated Chinese intellectuals to construct Sinocentric ethno-nationalism during the period from the late 1920s to the early 1940s. It shows that the theory was first popularized by foreign scientists in Beijing, and the Peking man discoveries further provided strong evidence for the idea that Central Asia, or to be more specific, Tibet, Xinjiang, and Mongolia, was the original cradle of humans. Chinese scholars in the late 1930s and 1940s appropriated the findings to construct the monogenesis theory of the Chinese, which designated that all the diverse ethnic groups within the territory of China shared a common ancestor back to antiquity.

  12. 76 FR 34720 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-14

    ... Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is... Committee: National Institute on Aging Special Emphasis Panel, Frontotemporal Dementia. Date: July 26,...

  13. 75 FR 54160 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-03

    ... Committee: National Institute on Aging Special Emphasis Panel; Menopause and Sleep Disorders. Date: October... Effects of Early Education. Date: October 22, 2010. Time: 10 a.m. to 1 p.m. Agenda: To review and...

  14. 75 FR 14174 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-24

    ...; Principle of Stem Cell Maturation. Date: June 1, 2010. Time: 12 p.m. to 3 p.m. Agenda: To review and... Assistance Program Nos. 93.866, Aging Research, National Institutes of Health, HHS) Dated: March 17,...

  15. The Rocks and Fossils of Glacier National Park: The Story of Their Origin and History

    USGS Publications Warehouse

    Ross, Clyde P.; Rezak, Richard

    1959-01-01

    The story of Glacier National Park begins about 500 million years ago, at a time when there were no mountains in the region - only a vast, exceedingly shallow sea, bordered by desolate plains. The sand, clay, and mud, in part very limy, that were laid down in this sea eventually hardened into the rocks that are now known as the Belt series. These are the principal rocks in the park. Scattered through these rocks are crinkled, limy masses of many forms, the remains of deposits made by colonies of algae. After the Belt series was laid down, successive seas slowly advanced and retreated through long ages across what is now Glacier National Park, burying the Belt rocks under younger ones. After another very long time, a gentle uplift, the forerunner of later events, brought this part of the continent above the reach of sea water for the last time. Much later, some 50 million years ago, the disturbance became far more intense. To climax this upheaval, a mass of rock thousands of feet thick and hundreds of miles long was shoved eastward for 35 miles or more. This tremendous dislocation, well exposed along the eastern boundary of the park, is known as the Lewis overthrust. When the rocks of the region emerged from the sea they began to be attacked by erosion. As successive periods of crustal movement and erosion continued, the younger rocks were slowly stripped off the Belt series and sculpture of the latter by weather and water shaped the early Rocky Mountains. The final episode in the park's geologic past was the ice age, beginning about a million years ago. Repeated advances and retreats of the great glaciers in the high valleys accentuated the mountain terrain and developed the scenic grandeur that is now Glacier National Park. One may say that the park is still in the ice age, for some glaciers still exist. The present report, companion to two more technical reports on the region, informally presents the story of the park's development through past eras for readers

  16. 78 FR 5191 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following meetings. ]...

  17. 75 FR 51082 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-18

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following meetings....

  18. 78 FR 30932 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meetings... Special Emphasis Panel; Heart Failure and Obesity. Date: July 10, 2013. Time: 1:00 p.m. to 5:00...

  19. National Security in the Nuclear Age: Public Library Proposal and Booklist. May 1987 Update.

    ERIC Educational Resources Information Center

    Dane, Ernest B.

    To increase public understanding of national security issues, this document proposes that a balanced and up-to-date collection of books and other materials on national security in the nuclear age be included in all U.S. public libraries. The proposal suggests that the books be grouped together on an identified shelf. Selection criteria for the…

  20. 78 FR 79706 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute on Aging; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following meeting. The...

  1. 77 FR 33475 - National Institute On Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-06

    ... Conference Call). Contact Person: Alicja L. Markowska, Ph.D., DSC, Scientific Review Branch, National... 20892 (Telephone Conference Call). Contact Person: Alicja L. Markowska, Ph.D., DSC, Scientific Review..., Ph.D., DSC, Scientific Review Branch, National Institute On Aging, ] 7201 Wisconsin Avenue,...

  2. 78 FR 26054 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-03

    ... Committee: National Institute on Aging Initial Review Group; Clinical Aging Review Committee, NIA-C. Date.... Place: Courtyard Long Beach Downtown, 500 East First Street, Long Beach, CA 90802. Contact Person... Building, 7201 Wisconsin Avenue, Suite 2C212, Bethesda, MD 20892, 301-496-9666 markowsa@nia.nih.gov ....

  3. Address by Dr. Robert N. Butler, Director, National Institute on Aging.

    ERIC Educational Resources Information Center

    Butler, Robert N.

    This address by the Director of the National Institute on Aging is a plea for the recognition of the necessity of fundamental research on the aging process. It cautions that new scientific discoveries need to be evaluated more carefully before they are used on humans, and warns that the effects of drugs and treatments on older people may vary from…

  4. 77 FR 14026 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-08

    ... Committee: National Institute on Aging Special Emphasis Panel; Reprogramming, Aging and Alzheimer's Disease... Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is... provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The...

  5. Personality-Informed Interventions for Healthy Aging: Conclusions from a National Institute on Aging Work Group

    ERIC Educational Resources Information Center

    Chapman, Benjamin P.; Hampson, Sarah; Clarkin, John

    2014-01-01

    We describe 2 frameworks in which personality dimensions relevant to health, such as Conscientiousness, can be used to inform interventions designed to promote health aging. First, contemporary data and theory do not suggest that personality is "immutable," but instead focus on questions of who changes, in what way, why, when, and how.…

  6. Thirty years of the United Nations and global ageing: an Australian perspective.

    PubMed

    Kendig, Hal; Lucas, Nina; Anstey, Kaarin J

    2013-10-01

    Over the past three decades, the United Nations (UN) has slowly devoted increasing attention to global ageing. Concern for individually based welfare or health-care programs for older people in developed countries has progressed to also consider the contributions of older people and implications of ageing for socioeconomic advancement in developing countries, including those in Asia Oceania. These shifts are evident in the International Plans of Action on Ageing from Vienna in 1982 to Madrid in 2002; recent 10-year reviews of the Madrid Plan; and current advocacy for inclusion of ageing in the influential UN Millennium Plan post-2015. Australia has demonstrated progressive policies and contributed to ageing developments by the UN, International Federation on Ageing the World Health Organization and the International Association of Gerontology. Key ideas driving further action are the importance of valuing people at all ages, addressing inequalities over the life-course and implementing human rights approaches to ageing.

  7. Correlates of age at first sexual intercourse in a national sample of young women.

    PubMed

    Bingham, C R; Miller, B C; Adams, G R

    1990-01-01

    A subsample of 814 sexually experienced adolescent females from the 1979 U.S. National Survey of Young Women was analyzed to assess the correlates of age at 1st sexual intercourse. Multiple regression procedures were used to examine sets of variables sequentially. In the hierarchical regression model, the control variables (respondent's age, race, religion, and age at menarche), along with 3 independent variables (household income, ideal age at 1st marriage, and ideal age for 1st birth), predicted age at 1st intercourse. The control variables accounted for a major portion of the variance in the model. Of the controls, chronological age and age at menarche were highly significant across all models tested. PMID:12343095

  8. Age-of-Recall Effects on Family-of-Origin Ratings.

    ERIC Educational Resources Information Center

    Hampson, Robert B.; And Others

    1994-01-01

    College students (n=141) completed Self-Report Family Inventory on Beavers Systems Model of Family Functioning, rating current family, family when they were 10 years old, and family when they were 16 years old. Found significant differences between age-of-recall groups, with recall ratings from age 10 significantly more competent, cohesive, and…

  9. Possible Origin of Improved High Temperature Performance of Hydrothermally Aged Cu/Beta Zeolite Catalysts

    SciTech Connect

    Peden, Charles HF; Kwak, Ja Hun; Burton, Sarah D.; Tonkyn, Russell G.; Kim, Do Heui; Lee, Jong H.; Jen, H. W.; Cavattaio, Giovanni; Cheng, Yisun; Lambert, Christine

    2012-04-30

    The hydrothermal stability of Cu/beta NH3 SCR catalysts are explored here. In particular, this paper focuses on the interesting ability of this catalyst to maintain and even enhance high-temperature performance for the "standard" SCR reaction after modest (900 °C, 2 hours) hydrothermal aging. Characterization of the fresh and aged catalysts was performed with an aim to identify possible catalytic phases responsible for the enhanced high temperature performance. XRD, TEM and 27Al NMR all showed that the hydrothermally aging conditions used here resulted in almost complete loss of the beta zeolite structure between 1 and 2 hours aging. While the 27Al NMR spectra of 2 and 10 hour hydrothermally-aged catalysts showed significant loss of a peak associated with tetrahedrally-coordinated Al species, no new spectral features were evident. Two model catalysts, suggested by these characterization data as possible mimics of the catalytic phase formed during hydrothermal aging of Cu/beta, were prepared and tested for their performance in the "standard" SCR and NH3 oxidation reactions. The similarity in their reactivity compared to the 2 hour hydrothermally-aged Cu/beta catalyst suggests possible routes for preparing multi-component catalysts that may have wider temperature windows for optimum performance than those provided by current Cu/zeolite catalysts.

  10. Reactive nitrogen oxides in the southeast United States national parks: source identification, origin, and process budget

    NASA Astrophysics Data System (ADS)

    Tong, Daniel Quansong; Kang, Daiwen; Aneja, Viney P.; Ray, John D.

    2005-01-01

    We present in this study both measurement-based and modeling analyses for elucidation of source attribution, influence areas, and process budget of reactive nitrogen oxides at two rural southeast United States sites (Great Smoky Mountains national park (GRSM) and Mammoth Cave national park (MACA)). Availability of nitrogen oxides is considered as the limiting factor to ozone production in these areas and the relative source contribution of reactive nitrogen oxides from point or mobile sources is important in understanding why these areas have high ozone. Using two independent observation-based techniques, multiple linear regression analysis and emission inventory analysis, we demonstrate that point sources contribute a minimum of 23% of total NOy at GRSM and 27% at MACA. The influence areas for these two sites, or origins of nitrogen oxides, are investigated using trajectory-cluster analysis. The result shows that air masses from the West and Southwest sweep over GRSM most frequently, while pollutants transported from the eastern half (i.e., East, Northeast, and Southeast) have limited influence (<10% out of all air masses) on air quality at GRSM. The processes responsible for formation and removal of reactive nitrogen oxides are investigated using a comprehensive 3-D air quality model (Multiscale Air Quality SImulation Platform (MAQSIP)). The NOy contribution associated with chemical transformations to NOz and O3, based on process budget analysis, is as follows: 32% and 84% for NOz, and 26% and 80% for O3 at GRSM and MACA, respectively. The similarity between NOz and O3 process budgets suggests a close association between nitrogen oxides and effective O3 production at these rural locations.

  11. Dental age estimation based on third molar eruption in First Nation people of Canada.

    PubMed

    Schmeling, A; Olze, A; Pynn, B R; Kraul, V; Schulz, R; Heinecke, A; Pfeiffer, H

    2010-12-01

    Forensic age estimation of living subjects has become an increasing focus of interest in modern society. One main criterion for dental age estimation in the relevant age group is the evaluation of third molar eruption. The importance of ethnic variation in dental development requires population specific data for dental age evaluation. In the present study, we determined the stages of third molar eruption in 347 female and 258 male First Nations people of Canada aged 11 to 29 years based on radiological evidence from 605 conventional orthopantomograms. The results presented here provide data on the age of alveolar, gingival, and complete eruption of the third molars in the occlusal plane that can be used for forensic estimation of the minimum and most probable ages of investigated individuals.

  12. Motivational Shifts in Aging Monkeys and the Origins of Social Selectivity.

    PubMed

    Almeling, Laura; Hammerschmidt, Kurt; Sennhenn-Reulen, Holger; Freund, Alexandra M; Fischer, Julia

    2016-07-11

    As humans age, they become more selective regarding their personal goals [1] and social partners [2]. Whereas the selectivity in goals has been attributed to losses in resources (e.g., physical strength) [3], the increasing focus on emotionally meaningful partners is, according to socioemotional selectivity theory, driven by the awareness of one's decreasing future lifetime [2]. Similar to humans, aging monkeys show physical losses [4] and reductions in social activity [2, 5-7]. To disentangle a general resource loss and the awareness of decreasing time, we combined field experiments with behavioral observations in a large age-heterogeneous population of Barbary macaques (Macaca sylvanus) at La Forêt des Singes. Novel object tests revealed a loss of interest in the nonsocial environment in early adulthood, which was modulated by the availability of a food reward. Experiments using vocal and visual representations of social partners indicated that monkeys maintained an interest in social stimuli and a preferential interest in friends and socially important individuals into old age. Old females engaged in fewer social interactions, although other group members continued to invest in relationships with them. Consequently, reductions in sociality were not due to a decrease in social interest. In conclusion, some of the motivational shifts observed in aging humans, particularly the increasing focus on social over nonsocial stimuli, may occur in the absence of a limited time perspective and are most likely deeply rooted in primate evolution. Our findings highlight the value of nonhuman primates as valuable models for understanding human aging [8, 9].

  13. Personality-Informed Interventions for Healthy Aging: Conclusions From a National Institute on Aging Workgroup

    PubMed Central

    Chapman, Benjamin P.; Hampson, Sarah; Clarkin, John

    2013-01-01

    We describe two frameworks in which personality dimensions relevant to health, such as Conscientiousness, can be used to inform interventions designed to promote health aging. First, contemporary data and theory do not suggest that personality is “immutable”, but instead focus on questions of who changes, in what way, why, when, and how. In fact, the notion that personality could be changed was part and parcel of many schools of psychotherapy, which suggested that long term and meaningful change in symptoms could not be achieved without change in relevant aspects of personality. We review intervention research documenting change in personality. Based on an integrative view of personality as a complex system, we describe a “bottom-up” model of change in which interventions to change basic personality processes eventuate in changes at the trait level. A second framework leverages the descriptive and predictive power of personality to tailor individual risk prediction and treatment, as well as refine public health programs, to the relevant dispositional characteristics of the target population. These methods dovetail with and add a systematic and rigorous psychosocial dimension to the personalized medicine and patient-centeredness movements in medicine. In addition to improving health through earlier intervention and increased fit between treatments and persons, cost-effectiveness improvements can be realized by more accurate resource allocation. Numerous examples from the personality, health, and aging literature on Conscientiousness and other traits are provided throughout, and we conclude with a series of recommendations for research in these emerging areas. PMID:23978300

  14. Age Changes in Personality and Their Origins: Comment on Roberts, Walton, and Viechtbauer (2006)

    ERIC Educational Resources Information Center

    Costa, Paul T.; McCrae, Robert R.

    2006-01-01

    This article presents comments on the original article "Patterns of Mean-Level Change in Personality Traits Across the Life Course: A Meta-Analysis of Longitudinal Studies," by B. W. Roberts, K. W. Walton, and W. Viechtbauer. Although Roberts et al depicted the present authors as proponents of the immutability of traits, in fact we have always…

  15. The Origin of a Killer Revealed by Bronze Age Yersinia Genomes.

    PubMed

    Nelson-Sathi, Shijulal; Martin, William F

    2015-11-11

    Bubonic plaque is caused by Yersinia pestis, a deadly pathogen that left deep scars in human history. Rasmussen et al. (2015) have now retrieved Y. pestis genomes from 2,800- to 5,000-year-old human teeth, shedding new light on origins of the strain that brought Black Death to Europe 670 years ago. PMID:26567502

  16. Obesity in emerging nations: evolutionary origins and the impact of a rapid nutrition transition.

    PubMed

    Prentice, Andrew M

    2009-01-01

    Here we explore whether there is any evidence that the rapid development of the obesity epidemic in emerging nations, and its unusual coexistence with malnutrition, may have evolutionary origins that make such populations especially vulnerable to the obesogenic conditions accompanying the nutrition transition. It is concluded that any selection of so-called 'thrifty genes' is likely to have affected most races due to the frequency and ubiquity of famines and seasonal food shortages in ancient populations. Although it remains a useful stimulus for research, the thrifty gene hypothesis remains a theoretical construct that so far lacks any concrete examples. There is currently little evidence that the ancestral genomes of native Asian or African populations carry particular risk alleles for obesity. Interestingly, however, there is evidence that a variant allele of the FTO gene that favors leanness may be less active in Asians or Africans. There is also some evidence that Caucasians may be less prone to developing type 2 diabetes mellitus than other races suggesting that there has been recent selection of protective alleles. In the near future, recently developed statistical methods for comparing genome-wide data across populations are likely to reveal or refute the presence of any thrifty genes and might indicate mechanisms of vulnerability. PMID:19346767

  17. 39Ar-40Ar "ages" and origin of excess 40Ar in Martian shergottites

    NASA Astrophysics Data System (ADS)

    Bogard, Donald; Park, Jisun; Garrison, Daniel

    2009-06-01

    We report new 39Ar-40Ar measurements on 15 plagioclase, pyroxene, and/or whole rock samples of 8 Martian shergottites. All age spectra suggest ages older than the meteorite formation ages, as defined by Sm-Nd and Rb-Sr isochrons. Employing isochron plots, only Los Angeles plagioclase and possibly Northwest Africa (NWA) 3171 plagioclase give ages in agreement with their formation ages. Isochrons for all shergottite samples reveal the presence of trapped Martian 40Ar (40Arxs), which exists in variable amounts in different lattice locations. Some 40Arxs is uniformly distributed throughout the lattice, resulting in a positive isochron intercept, and other 40Arxs occurs in association with K-bearing minerals and increases the isochron slope. These samples demonstrate situations where linear Ar isochrons give false ages that are too old. After subtracting 40Ar*that would accumulate by 40K decay since meteorite formation and small amounts of terrestrial 40Ar, all young age samples give similar 40Arxs concentrations of ˜1-2 × 10-6cm3/g, but a variation in K content by a factor of ˜80. Previously reported NASA Johnson Space Center data for Zagami, Shergotty, Yamato (Y-) 000097, Y-793605, and Queen Alexandra Range (QUE) 94201 shergottites show similar concentrations of 40Arxs to the new meteorite data reported here. Similar 40Arxs in different minerals and meteorites cannot be explained as arising from Martian atmosphere carried in strongly shocked phases such as melt veins. We invoke the explanation given by Bogard and Park (2008) for Zagami, that this 40Arxs in shergottites was acquired from the magma. Similarity in 40Arxs among shergottites may reveal common magma sources and/or similar magma generation and emplacement processes.

  18. Out of Tibet: Pliocene woolly rhino suggests high-plateau origin of Ice Age megaherbivores.

    PubMed

    Deng, Tao; Wang, Xiaoming; Fortelius, Mikael; Li, Qiang; Wang, Yang; Tseng, Zhijie J; Takeuchi, Gary T; Saylor, Joel E; Säilä, Laura K; Xie, Guangpu

    2011-09-01

    Ice Age megafauna have long been known to be associated with global cooling during the Pleistocene, and their adaptations to cold environments, such as large body size, long hair, and snow-sweeping structures, are best exemplified by the woolly mammoths and woolly rhinos. These traits were assumed to have evolved as a response to the ice sheet expansion. We report a new Pliocene mammal assemblage from a high-altitude basin in the western Himalayas, including a primitive woolly rhino. These new Tibetan fossils suggest that some megaherbivores first evolved in Tibet before the beginning of the Ice Age. The cold winters in high Tibet served as a habituation ground for the megaherbivores, which became preadapted for the Ice Age, successfully expanding to the Eurasian mammoth steppe. PMID:21885780

  19. Behavioral Autonomy Age Expectations among Mexican-Origin Mother-Daughter Dyads: An Examination of Within-Group Variability

    PubMed Central

    Bámaca-Colbert, Mayra Y.; Umaña-Taylor, Adriana J.; Espinosa-Hernández, Graciela; Brown, Ashley M.

    2011-01-01

    This study examined differences in behavioral autonomy age expectations between Mexican-origin mothers and their adolescent daughters (N = 319 dyads); variability in behavioral autonomy age expectations as a function of nativity and maternal educational attainment also was examined. Findings indicated significant differences between mothers and daughters such that mothers reported later expectations for the timing of behavioral autonomy than did daughters. Follow-up analyses indicated that findings appeared to be driven by maternal nativity, with dyads comprised of Mexico-born mothers reporting the latest age expectations for behavioral autonomy when compared with dyads comprised of U.S.-born mothers. Findings underscore the need to examine normative development among Latino adolescents and their families with a specific focus on how sociocultural characteristics can contribute to within-family differences. PMID:22093152

  20. Motivational Shifts in Aging Monkeys and the Origins of Social Selectivity.

    PubMed

    Almeling, Laura; Hammerschmidt, Kurt; Sennhenn-Reulen, Holger; Freund, Alexandra M; Fischer, Julia

    2016-07-11

    As humans age, they become more selective regarding their personal goals [1] and social partners [2]. Whereas the selectivity in goals has been attributed to losses in resources (e.g., physical strength) [3], the increasing focus on emotionally meaningful partners is, according to socioemotional selectivity theory, driven by the awareness of one's decreasing future lifetime [2]. Similar to humans, aging monkeys show physical losses [4] and reductions in social activity [2, 5-7]. To disentangle a general resource loss and the awareness of decreasing time, we combined field experiments with behavioral observations in a large age-heterogeneous population of Barbary macaques (Macaca sylvanus) at La Forêt des Singes. Novel object tests revealed a loss of interest in the nonsocial environment in early adulthood, which was modulated by the availability of a food reward. Experiments using vocal and visual representations of social partners indicated that monkeys maintained an interest in social stimuli and a preferential interest in friends and socially important individuals into old age. Old females engaged in fewer social interactions, although other group members continued to invest in relationships with them. Consequently, reductions in sociality were not due to a decrease in social interest. In conclusion, some of the motivational shifts observed in aging humans, particularly the increasing focus on social over nonsocial stimuli, may occur in the absence of a limited time perspective and are most likely deeply rooted in primate evolution. Our findings highlight the value of nonhuman primates as valuable models for understanding human aging [8, 9]. PMID:27345168

  1. Life-course origins of the ages at menarche and menopause

    PubMed Central

    Forman, Michele R; Mangini, Lauren D; Thelus-Jean, Rosenie; Hayward, Mark D

    2013-01-01

    A woman’s age at menarche (first menstrual period) and her age at menopause are the alpha and omega of her reproductive years. The timing of these milestones is critical for a woman’s health trajectory over her lifespan, as they are indicators of ovarian function and aging. Both early and late timing of either event are associated with risk for adverse health and psychosocial outcomes. Thus, the search for a relationship between age at menarche and menopause has consequences for chronic disease prevention and implications for public health. This article is a review of evidence from the fields of developmental biology, epidemiology, nutrition, demography, sociology, and psychology that examine the menarche–menopause connection. Trends in ages at menarche and menopause worldwide and in subpopulations are presented; however, challenges exist in constructing trends. Among 36 studies that examine the association between the two sentinel events, ten reported a significant direct association, two an inverse association, and the remainder had null findings. Multiple factors, including hormonal and environmental exposures, socioeconomic status, and stress throughout the life course are hypothesized to influence the tempo of growth, including body size and height, development, menarche, menopause, and the aging process in women. The complexity of these factors and the pathways related to their effects on each sentinel event complicate evaluation of the relationship between menarche and menopause. Limitations of past investigations are discussed, including lack of comparability of socioeconomic status indicators and biomarker use across studies, while minority group differences have received scant attention. Suggestions for future directions are proposed. As research across endocrinology, epidemiology, and the social sciences becomes more integrated, the confluence of perspectives will yield a richer understanding of the influences on the tempo of a woman

  2. The age and origin of the Pacific islands: a geological overview.

    PubMed

    Neall, Vincent E; Trewick, Steven A

    2008-10-27

    The Pacific Ocean evolved from the Panthalassic Ocean that was first formed ca 750 Ma with the rifting apart of Rodinia. By 160 Ma, the first ocean floor ascribed to the current Pacific plate was produced to the west of a spreading centre in the central Pacific, ultimately growing to become the largest oceanic plate on the Earth. The current Nazca, Cocos and Juan de Fuca (Gorda) plates were initially one plate, produced to the east of the original spreading centre before becoming split into three. The islands of the Pacific have originated as: linear chains of volcanic islands on the above plates either by mantle plume or propagating fracture origin, atolls, uplifted coralline reefs, fragments of continental crust, obducted portions of adjoining lithospheric plates and islands resulting from subduction along convergent plate margins. Out of the 11 linear volcanic chains identified, each is briefly described and its history summarized. The geology of 10 exemplar archipelagos (Japan, Izu-Bonin, Palau, Solomons, Fiji, New Caledonia, New Zealand, Society, Galápagos and Hawaii) is then discussed in detail. PMID:18768382

  3. Improved measures for the cross-national comparison of age profiles of internal migration.

    PubMed

    Bernard, Aude; Bell, Martin; Charles-Edwards, Elin

    2014-01-01

    We develop and demonstrate the application of a concise set of measures intended to encapsulate key features of the age profile of internal migration and highlight the significant differences that exist between nations in these profiles. Model schedules have been the most common method of comparing internal migration patterns but issues related to the estimation and interpretation of their parameters hinder their use for cross-national comparison. We demonstrate that the interpretation of exponential coefficients as rates of ascent and descent does not best reflect the slopes of migration age profiles, and we propose more consistent measures based on the rate of change in migration intensity. We demonstrate, through correlation and factor analysis, that most of the inter-country variance in migration age profiles is captured by the age at and intensity of peak migration. The application of these two indicators to 25 countries reveals significant differences between regions.

  4. HIV infection among people of foreign origin voluntarily tested in Spain. A comparison with national subjects

    PubMed Central

    The, E

    2002-01-01

    Objectives: To describe exposure categories and HIV prevalence among subjects voluntarily tested in Spain by country of origin. Methods: HIV prevalence and exposure categories were compared between national and non-Spanish subjects voluntarily tested in 18 sexually transmitted disease/HIV testing clinics from 16 Spanish cities in 2000. Results: Of 8861 testers, 2810 (31.7%) came from foreign countries; 73.1% from Latin America, 9.1% from western Europe, 6.2% from central/eastern Europe, 4.4% from northern Africa, and 4.2% from sub-Sahara Africa. Among women from Latin America, 78% were sex workers compared to 5.5% Spanish women. HIV infection was diagnosed in 170 persons, 34.7% from foreign countries. HIV prevalence for Spanish subjects (23% for men and 1.0% for women) was significantly different from men and women from Latin America (11.3% and 0.3% respectively), Sub-Saharan Africa (9.1% and 7.5% respectively), and women from the north of Africa (11.8%). Compared with Spaniards, analyses of persons of the same exposure category showed higher HIV prevalence in men who had sex with men from Latin America (odds ratio: 4.1; 95% CI: 2.4–6.9), heterosexual men from sub-Sahara Africa (OR: 19.3; 95% CI: 6.4–58.0), and Latin America (OR: 9.4; 95% CI: 3.4–25.9), heterosexual women from sub-Sahara Africa (OR: 16.9; 95% CI: 3.5–82.4) and from northern Africa (OR: 15.3; 95% CI: 3.2–73.2). Conclusions: An important proportion of HIV testers from these clinics came from foreign countries and some groups showed a high prevalence of HIV infection. Specific prevention and testing programmes adapted to the needs of migrants in Spain should be developed. PMID:12181461

  5. Age and origin of carlsbad cavern and related caves from 40Ar/39Ar of alunite

    PubMed

    Polyak; McIntosh; Guven; Provencio

    1998-03-20

    40Ar/39Ar dating of fine-grained alunite that formed during cave genesis provides ages of formation for the Big Room level of Carlsbad Cavern [4.0 to 3.9 million years ago (Ma)], the upper level of Lechuguilla Cave (6.0 to 5.7 Ma), and three other hypogene caves (11.3 to 6.0 Ma) in the Guadalupe Mountains of New Mexico. Alunite ages increase and are strongly correlative with cave elevations, which indicates an 1100-meter decline in the water table, apparently related to tectonic uplift and tilting, from 11.3 Ma to the present. 40Ar/39Ar dating studies of the hypogene caves have the potential to help resolve late Cenozoic climatic, speleologic, and tectonic questions.

  6. The origin of early age expansions induced in cementitious materials containing shrinkage reducing admixtures

    SciTech Connect

    Sant, Gaurav; Lothenbach, Barbara; Juilland, Patrick; Le Saout, Gwenn; Weiss, Jason; Scrivener, Karen

    2011-03-15

    Studies on the early-age shrinkage behavior of cement pastes, mortars, and concretes containing shrinkage reducing admixtures (SRAs) have indicated these mixtures frequently exhibit an expansion shortly after setting. While the magnitude of the expansion has been noted to be a function of the chemistry of the cement and the admixture dosage; the cause of the expansion is not clearly understood. This investigation uses measurements of autogenous deformation, X-ray diffraction, pore solution analysis, thermogravimetry, and scanning electron microscopy to study the early-age properties and describe the mechanism of the expansion in OPC pastes made with and without SRA. The composition of the pore solution indicates that the presence of the SRA increases the portlandite oversaturation level in solution which can result in higher crystallization stresses which could lead to an expansion. This observation is supported by deformation calculations for the systems examined.

  7. Apoptosis: its origin, history, maintenance and the medical implications for cancer and aging

    NASA Astrophysics Data System (ADS)

    Kaczanowski, Szymon

    2016-06-01

    Programmed cell death is a basic cellular mechanism. Apoptotic-like programmed cell death (called apoptosis in animals) occurs in both unicellular and multicellular eukaryotes, and some apoptotic mechanisms are observed in bacteria. Endosymbiosis between mitochondria and eukaryotic cells took place early in the eukaryotic evolution, and some of the apoptotic-like mechanisms of mitochondria that were retained after this event now serve as parts of the eukaryotic apoptotic machinery. Apoptotic mechanisms have several functions in unicellular organisms: they include kin-selected altruistic suicide that controls population size, sharing common goods, and responding to viral infection. Apoptotic factors also have non-apoptotic functions. Apoptosis is involved in the cellular aging of eukaryotes, including humans. In addition, apoptosis is a key part of the innate tumor-suppression mechanism. Several anticancer drugs induce apoptosis, because apoptotic mechanisms are inactivated during oncogenesis. Because of the ancient history of apoptosis, I hypothesize that there is a deep relationship between mitochondrial metabolism, its role in aerobic versus anaerobic respiration, and the connection between apoptosis and cancer. Whereas normal cells rely primarily on oxidative mitochondrial respiration, most cancer cells use anaerobic metabolism. According to the Warburg hypothesis, the remodeling of the metabolism is one of the processes that leads to cancer. Recent studies indicate that anaerobic, non-mitochondrial respiration is particularly active in embryonic cells, stem cells, and aggressive stem-like cancer cells. Mitochondrial respiration is particularly active during the pathological aging of human cells in neurodegenerative diseases. According to the reversed Warburg hypothesis formulated by Demetrius, pathological aging is induced by mitochondrial respiration. Here, I advance the hypothesis that the stimulation of mitochondrial metabolism leads to pathological aging.

  8. Origin of the slow dynamics and the aging of a soft glass.

    PubMed

    Mazoyer, Sylvain; Cipelletti, Luca; Ramos, Laurence

    2006-12-01

    We study by light microscopy a soft glass consisting of a compact arrangement of polydisperse multilamellar vesicles. We show that its slow and nonstationary dynamics results from the unavoidable small fluctuations of temperature, which induce intermittent local shear deformations in the sample, because of thermal expansion and contraction. Temperature-induced shear provokes both reversible and irreversible rearrangements whose amplitude decreases with time, leading to an exponential slowing down of the dynamics with sample age. PMID:17280252

  9. Apoptosis: its origin, history, maintenance and the medical implications for cancer and aging.

    PubMed

    Kaczanowski, Szymon

    2016-01-01

    Programmed cell death is a basic cellular mechanism. Apoptotic-like programmed cell death (called apoptosis in animals) occurs in both unicellular and multicellular eukaryotes, and some apoptotic mechanisms are observed in bacteria. Endosymbiosis between mitochondria and eukaryotic cells took place early in the eukaryotic evolution, and some of the apoptotic-like mechanisms of mitochondria that were retained after this event now serve as parts of the eukaryotic apoptotic machinery. Apoptotic mechanisms have several functions in unicellular organisms: they include kin-selected altruistic suicide that controls population size, sharing common goods, and responding to viral infection. Apoptotic factors also have non-apoptotic functions. Apoptosis is involved in the cellular aging of eukaryotes, including humans. In addition, apoptosis is a key part of the innate tumor-suppression mechanism. Several anticancer drugs induce apoptosis, because apoptotic mechanisms are inactivated during oncogenesis. Because of the ancient history of apoptosis, I hypothesize that there is a deep relationship between mitochondrial metabolism, its role in aerobic versus anaerobic respiration, and the connection between apoptosis and cancer. Whereas normal cells rely primarily on oxidative mitochondrial respiration, most cancer cells use anaerobic metabolism. According to the Warburg hypothesis, the remodeling of the metabolism is one of the processes that leads to cancer. Recent studies indicate that anaerobic, non-mitochondrial respiration is particularly active in embryonic cells, stem cells, and aggressive stem-like cancer cells. Mitochondrial respiration is particularly active during the pathological aging of human cells in neurodegenerative diseases. According to the reversed Warburg hypothesis formulated by Demetrius, pathological aging is induced by mitochondrial respiration. Here, I advance the hypothesis that the stimulation of mitochondrial metabolism leads to pathological aging

  10. Internal versus external controls on age variability: Definitions, origins and implications in a changing climate

    NASA Astrophysics Data System (ADS)

    Helton, A. M.; Poole, G. C.; Payn, R. A.; Izurieta, C.; Wright, M.; Bernhardt, E. S.; Stanford, J. A.

    2014-12-01

    The unsteadiness of stream water age is now well established, but the controls on the age dynamics, and the adequate representation and prediction of those dynamics, are not. A basic distinction can be made between internal variability that arises from changes in the proportions of flow moving through the diverse flow pathways of a hydrologic system, and external variability that arises from the stochasticity of inputs and outputs (such as precipitation and streamflow). In this talk I will show how these two types of age variability can be formally defined and distinguished within the framework of rank StorAge Selection (rSAS) functions. Internal variability implies variations in time in the rSAS function, while external variability does not. This leads naturally to the definition of several modes of internal variability, reflecting generic ways that system flowpaths may be rearranged. This rearrangement may be induced by fluctuations in the system state (such as catchment wetness), or by longer-term changes in catchment structure (such as land use change). One type of change, the 'inverse storage effect' is characterized by an increase in the release of young water from the system in response to an increase in overall system storage. This effect can be seen in many hydrologic settings, and has important implications for the effect of altered hydroclimatic conditions on solute transport through a landscape. External variability, such as increased precipitation, can induce a decrease in mean transit time (and vice versa), but this effect is greatly enhanced if accompanied by an internal shift in flow pathways that increases the relative importance of younger water. These effects will be illustrated using data from field and experimental studies.

  11. Internal versus external controls on age variability: Definitions, origins and implications in a changing climate

    NASA Astrophysics Data System (ADS)

    Harman, C. J.

    2015-12-01

    The unsteadiness of stream water age is now well established, but the controls on the age dynamics, and the adequate representation and prediction of those dynamics, are not. A basic distinction can be made between internal variability that arises from changes in the proportions of flow moving through the diverse flow pathways of a hydrologic system, and external variability that arises from the stochasticity of inputs and outputs (such as precipitation and streamflow). In this talk I will show how these two types of age variability can be formally defined and distinguished within the framework of rank StorAge Selection (rSAS) functions. Internal variability implies variations in time in the rSAS function, while external variability does not. This leads naturally to the definition of several modes of internal variability, reflecting generic ways that system flowpaths may be rearranged. This rearrangement may be induced by fluctuations in the system state (such as catchment wetness), or by longer-term changes in catchment structure (such as land use change). One type of change, the 'inverse storage effect' is characterized by an increase in the release of young water from the system in response to an increase in overall system storage. This effect can be seen in many hydrologic settings, and has important implications for the effect of altered hydroclimatic conditions on solute transport through a landscape. External variability, such as increased precipitation, can induce a decrease in mean transit time (and vice versa), but this effect is greatly enhanced if accompanied by an internal shift in flow pathways that increases the relative importance of younger water. These effects will be illustrated using data from field and experimental studies.

  12. Apoptosis: its origin, history, maintenance and the medical implications for cancer and aging.

    PubMed

    Kaczanowski, Szymon

    2016-05-11

    Programmed cell death is a basic cellular mechanism. Apoptotic-like programmed cell death (called apoptosis in animals) occurs in both unicellular and multicellular eukaryotes, and some apoptotic mechanisms are observed in bacteria. Endosymbiosis between mitochondria and eukaryotic cells took place early in the eukaryotic evolution, and some of the apoptotic-like mechanisms of mitochondria that were retained after this event now serve as parts of the eukaryotic apoptotic machinery. Apoptotic mechanisms have several functions in unicellular organisms: they include kin-selected altruistic suicide that controls population size, sharing common goods, and responding to viral infection. Apoptotic factors also have non-apoptotic functions. Apoptosis is involved in the cellular aging of eukaryotes, including humans. In addition, apoptosis is a key part of the innate tumor-suppression mechanism. Several anticancer drugs induce apoptosis, because apoptotic mechanisms are inactivated during oncogenesis. Because of the ancient history of apoptosis, I hypothesize that there is a deep relationship between mitochondrial metabolism, its role in aerobic versus anaerobic respiration, and the connection between apoptosis and cancer. Whereas normal cells rely primarily on oxidative mitochondrial respiration, most cancer cells use anaerobic metabolism. According to the Warburg hypothesis, the remodeling of the metabolism is one of the processes that leads to cancer. Recent studies indicate that anaerobic, non-mitochondrial respiration is particularly active in embryonic cells, stem cells, and aggressive stem-like cancer cells. Mitochondrial respiration is particularly active during the pathological aging of human cells in neurodegenerative diseases. According to the reversed Warburg hypothesis formulated by Demetrius, pathological aging is induced by mitochondrial respiration. Here, I advance the hypothesis that the stimulation of mitochondrial metabolism leads to pathological aging.

  13. Age and origin of the Cortlandt Complex, New York: Implications from Sm-Nd data

    USGS Publications Warehouse

    Domenick, M.A.; Basu, A.R.

    1982-01-01

    Sm-Nd systematics for nine whole-rock samples of hornblende norites, pyroxenites and a lamprophyre from various parts of the Cortlandt Complex were analyzed. Six of these samples from the central and eastern parts of the complex give an isochron age of 430??34 (2 ??) Ma with an e{open}Nd value of -2.9??0.5, and the other three samples from the western part, including the lamprophyre, define a similar age of 394??33 (2 ??) Ma but with a distinctly different e{open}Nd value of -1.4??0.4. The two different initial 143Nd/144Nd ratios corresponding to these e{open}-values are interpreted to reflect continental crustal contamination of the lamprophyric parental liquid prior to final emplacement and crystal fractionation to produce the different rock types of the complex. The intrusion age of 430 Ma for the complex clearly post-dates the major metamorphic event of the Taconic orogeny. The Nd-isotopic data also suggest a relationship between the Cortlandt Complex and a belt of lamprophyric dike rocks to the west, known as the Beemerville trend, which cuts across the metamorphic trends of the Taconic (Ratcliffe 1981). ?? 1982 Springer-Verlag.

  14. Depressed rates of origination and extinction during the late Paleozoic ice age: A new state for the global marine ecosystem

    NASA Astrophysics Data System (ADS)

    Stanley, Steven M.; Powell, Matthew G.

    2003-10-01

    Rates of origination and extinction for marine animal genera dropped to low levels in latest Mississippian time, immediately after massive glaciers formed in the Southern Hemisphere and a second-order mass extinction occurred. Evolutionary turnover and diversity remained low for ˜50 m.y., shifting markedly upward precisely when extensive glaciation ended in Early Permian time. All diverse taxa with good fossil records experienced low rates of origination and extinction during this major ice age. Such sluggish rates would be predicted for faunas of shallow seas on or adjacent to a heavily glaciated supercontinent such as Pangea, where cool and highly seasonal thermal regimes should dictate that species have broad ecological niches, widespread geographic distributions, and large and relatively stable populations.

  15. Trends and correlates of age at menarche in Colombia: Results from a nationally representative survey.

    PubMed

    Jansen, Erica C; Herrán, Oscar F; Villamor, Eduardo

    2015-12-01

    Surveillance of age at menarche could provide useful information on the impact of changing environmental conditions on child health. Nevertheless, nationally representative data are exceedingly rare. The aim of this study was to examine trends and sociodemographic correlates of age at menarche of Colombian girls. The study sample included 15,441 girls born between 1992 and 2000 who participated in the Colombian National Nutrition Survey of 2010. We estimated median menarcheal age using Kaplan-Meier time-to-event analyses. Hazard ratios with 95% confidence intervals were estimated with Cox regression models. The median age at menarche was 12.6 years. There was an estimated decline of 0.54 years/decade (P<0.001) over the birth years; this decline was only observed among girls from urban areas, and was more pronounced among girls from wealthier versus poorer families. Child height and BMI, maternal BMI and education, and family wealth were each inversely associated with menarcheal age whereas food insecurity and number of children in the household were positively associated with age at menarche. In conclusion, a negative trend in age at menarche is ongoing in Colombia, especially in groups most likely to benefit from socioeconomic development.

  16. Origin, variability and age of biomass burning plumes intercepted during BORTAS-B

    NASA Astrophysics Data System (ADS)

    Finch, D. P.; Palmer, P. I.; Parrington, M.

    2014-12-01

    We use the GEOS-Chem atmospheric chemistry transport model to interpret aircraft measurements of carbon monoxide (CO) in biomass burning outflow taken during the 2011 BORTAS-B campaign over eastern Canada. The model has some skill reproducing the observed variability, with a Spearman's rank correlation rs = 0.65, but has a positive negative bias for observations <100 ppb and a negative bias for observations > 300 ppb. We find that observed CO variations are largely due to fires over Ontario, as expected, with smaller and less variable contributions from fossil fuel combustion from eastern Asia and NE North America. To help interpret observed variations of CO we develop a Eulerian effective physical age of emissions (A) metric, accounting for mixing and chemical decay, which we apply to pyrogenic emissions of CO. We find that during BORTAS-B the age of emissions intercepted over Halifax, Nova Scotia is typically 4-11 days, and on occasion as young as two days. We show that A is typically 1-5 days older than the associated photochemical ages inferred from co-located measurements of different hydrocarbons. We find that the frequency distribution of differences between the age measures (Δτ) in plumes (defined by CH3CN > 150 ppt) peaks at 3 days. This corresponds to a chemical retardation of 50%. We find a strong relationship in biomass burning plumes between A and Δτ (r2 = 0.80), which is not present outwith these plumes (r2 = 0.28). We argue that these observed relationships, together with a robust observed relationship between CO and black carbon aerosol during BORTAS-B (r2 > 0.7), form the basis of indirect evidence that aerosols co-emitted with gases during pyrolysis markedly slowed down the plume photochemistry during BORTAS-B with respect to photochemistry at the same latitude and altitude in

  17. Carry A. Nation: "The Famous and Original Bar Room Smasher" Curriculum Packet.

    ERIC Educational Resources Information Center

    Kansas State Historical Society, Topeka.

    Carry Nation's personality, religious beliefs, and marriages to Charles Gloyd and, after his death, to David Nation all formed her into the reformer for which she became known. Carry Nation was involved in a variety of reform causes including prohibition, anti-smoking, women's health, and suffrage. Her prohibition reform efforts took place after…

  18. 75 FR 16489 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ...: National Institute on Aging Special Emphasis Panel; Diet Restriction. Date: May 6, 2010. Time: 1 p.m. to 4... and Dementia. Date: May 17, 2010. Time: 11 a.m. to 2 p.m. Agenda: To review and evaluate...

  19. National Security in the Nuclear Age. A Proposed Booklist and Public Education Ideas for Libraries.

    ERIC Educational Resources Information Center

    Dane, Ernest B.

    A bibliography on national security in the nuclear age is divided into three sections. The first section describes a proposal calling for the compilation of a balanced and up-to-date collection of books and other materials on this issue to be included in all U.S. public libraries. Also discussed are selection criteria for the book list, project…

  20. The Third National Health and Nutrition Examination Survey: Contributing Data on Aging and Health.

    ERIC Educational Resources Information Center

    Burt, Vicki L.; Harris, Tamara

    1994-01-01

    Describes third National Health and Nutrition Examination Survey (NHANES III), noting that upper age limit was removed and that older black, Mexican American, and white populations were oversampled. Sees NHANES III component for older adults providing multidimensional overview of physical and functional health status (osteoporosis; arthritis;…

  1. 78 FR 63999 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-25

    ... Committee: National Institute on Aging Special Emphasis Panel; Alzheimer's Disease Sequencing Project. Date... Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is... provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The...

  2. 78 FR 66015 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... Committee: National Institute on Aging Special Emphasis Panel; Drug Development for Alzheimer's Disease... Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is... provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The...

  3. 76 FR 17929 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-31

    ... Committee: National Institute on Aging Special Emphasis Panel; Drug Development for Alzheimer's Disease... Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is... provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The...

  4. 76 FR 19105 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    ... Committee: National Institute on Aging Special Emphasis Panel; Pathobiology of Alzheimer's Disease. Date... Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is... provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The...

  5. 77 FR 21790 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    ... Committee: National Institute on Aging Special Emphasis Panel; Pathology of Alzheimer's Disease. Date: May 7... Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is... provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The...

  6. 77 FR 56856 - National Institute on Aging; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    ... Committee: National Institute on Aging Special Emphasis Panel; Alzheimer's Network. Date: October 4, 2012... Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is... provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The...

  7. 76 FR 28236 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-16

    ... Committee: National Institute on Aging Special Emphasis Panel, Pathology of Alzheimer's Disease. Date: June... Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is... provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The...

  8. 77 FR 26770 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-07

    ... Committee: National Institute on Aging Special Emphasis Panel; Presenilin and Alzheimer's Disease. Date... Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is... provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The...

  9. 77 FR 9670 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-17

    ... Committee: National Institute on Aging Special Emphasis Panel; Alzheimer's Prevention. Date: March 1, 2012... Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is... provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The...

  10. 76 FR 1625 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-11

    ... Committee: National Institute on Aging Special Emphasis Panel; Drug Development for Alzheimer's Disease 2011... Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is... provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The...

  11. 77 FR 29677 - National Institute on Aging Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-18

    ....gov . Name of Committee: National Institute on Aging Special Emphasis Panel; Alzheimer's Disease Study... Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is... provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The...

  12. 75 FR 56116 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-15

    ... Committee: National Institute on Aging Special Emphasis Panel, Alzheimer's Disease Genetics. Date: October 4... Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is... provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The...

  13. 78 FR 62639 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ... of Committee: National Institute on Aging Special Emphasis Panel; Alzheimer's Disease Research... Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is... provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The...

  14. 77 FR 50704 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-22

    ... Committee: National Institute on Aging Special Emphasis Panel, Drug Development for Alzheimer's Disease... Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is... provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The...

  15. Health Disparities Grants Funded by National Institute on Aging: Trends between 2000 and 2010

    ERIC Educational Resources Information Center

    Kim, Giyeon; DeCoster, Jamie; Huang, Chao-Hui; Parmelee, Patricia

    2012-01-01

    Purpose of the Study: The present study examined the characteristics of health disparities grants funded by National Institute on Aging (NIA) from 2000 to 2010. Objectives were (a) to examine longitudinal trends in health disparities-related grants funded by NIA and (b) to identify moderators of these trends. Design and Methods: Our primary data…

  16. The National Treatment Improvement Evaluation Study (NTIES): Profile of Clients Age 45 and Over.

    ERIC Educational Resources Information Center

    Caliber Associates, Fairfax, VA.

    This paper summarizes similarities and differences between two cohorts of the National Treatment Improvement Evaluation Study (NTIES) clients, those age 45 or older and those younger than 45. Results reveal the following: Clients in the 45+ cohort were considerably more likely to be treated for problems with alcohol or with heroin, and they were…

  17. Microscopic Origin of the Logarithmic Time Evolution of Aging Processes in Complex Systems

    NASA Astrophysics Data System (ADS)

    Lomholt, Michael A.; Lizana, Ludvig; Metzler, Ralf; Ambjörnsson, Tobias

    2013-05-01

    There exists compelling experimental evidence in numerous systems for logarithmically slow time evolution, yet its full theoretical understanding remains elusive. We here introduce and study a generic transition process in complex systems, based on nonrenewal, aging waiting times. Each state n of the system follows a local clock initiated at t=0. The random time τ between clock ticks follows the waiting time density ψ(τ). Transitions between states occur only at local clock ticks and are hence triggered by the local forward waiting time, rather than by ψ(τ). For power-law forms ψ(τ)≃τ-1-α (0<α<1) we obtain a logarithmic time evolution of the state number ⟨n(t)⟩≃log⁡(t/t0), while for α>2 the process becomes normal in the sense that ⟨n(t)⟩≃t. In the intermediate range 1<α<2 we find the power-law growth ⟨n(t)⟩≃tα-1. Our model provides a universal description for transition dynamics between aging and nonaging states.

  18. The origin and age of the Alpha-Mendeleev and Lomonosov ridges in the Amerasia Basin

    NASA Astrophysics Data System (ADS)

    Verzhbitskii, E. V.; Lobkovskii, L. I.; Byakov, A. F.; Kononov, M. V.

    2013-02-01

    The results of the bathymetry simulation indicate the emplacement of the Mesozoic Arctic plume into the lithosphere of the Alpha-Mendeleev and Lomonosov ridges. The study also presents a model of the thermal subsidence to the asthenosphere. The calculated coefficients are compared with those obtained for the Greenland-Iceland and Iceland-Faeroe ridges, which were formed in response to hotspot activity. It was shown that the coefficients of the thermal subsidence in the central part of the Alpha-Mendeleev and Lomonosov Ridges are similar to those calculated for the Greenland-Iceland and Iceland-Faeroe ridges. This indicates the thermal regime of the subsidence of the Alpha-Mendeleev and Lomonosov ridges since the Early Miocene and the increased influence of the Arctic plume on the ridge genesis. The ridges are interpreted to have formed over a broad geological timeframe, from the late Cretaceous to the Cenozoic. A geothermal method, which is highly informative in terms of the age of the lithosphere, provides better constraints on the timing of ridge formation. The age estimates for the Alpha-Mendeleev (97-79 Ma) and Lomonosov ridges (69-57 Ma) derived from the geothermal data allowed us to draw a convincing conclusion about the genesis of these ridges.

  19. Ribosome origins: The relative age of 23S rRNA Domains

    NASA Astrophysics Data System (ADS)

    Hury, James; Nagaswamy, Uma; Larios-Sanz, Maia; Fox, George E.

    2006-08-01

    The modern ribosome and its component RNAs are quite large and it is likely that at an earlier time they were much smaller. Hence, not all regions of the modern ribosomal RNAs (rRNA) are likely to be equally old. In the work described here, it is hypothesized that the oldest regions of the RNAs will usually be highly integrated into the machinery. When this is the case, an examination of the interconnectivity between local RNA regions can provide insight to the relative age of the various regions. Herein, we describe an analysis of all known long-range RNA/RNA interactions within the 23S rRNA and between the 23S rRNA and the 16S rRNA in order to assess the interconnectivity between the usual Domains as defined by secondary structure. Domain V, which contains the peptidyl transferase center is centrally located, extensively connected, and therefore likely to be the oldest region. Domain IV and Domain II are extensively interconnected with both themselves and Domain V. A portion of Domain IV is also extensively connected with the 30S subunit and hence Domain IV may be older than Domain II. These results are consistent with other evidence relating to the relative age of RNA regions. Although the relative time of addition of the GTPase center can not be reliably deduced it is pointed out that the development of this may have dramatically affected the progenotes that preceded the last common ancestor.

  20. National and Post-National Discourses and the Construction of Linguistic Identities by Students of Albanian Origin in Greece

    ERIC Educational Resources Information Center

    Archakis, Argiris

    2016-01-01

    Drawing on Critical Discourse Analysis and, more specifically, on the relationship between the macro-level of dominant discourses and the micro-level of individual positionings, we examine the way linguistic identities are constructed by immigrant students of Albanian origin in Greece. We elaborate on two "competitive" discourses: the…

  1. Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline

    PubMed Central

    Crawford, Abbe H.; Tripathi, Richa B.; Richardson, William D.; Franklin, Robin J.M.

    2016-01-01

    Summary Oligodendrocyte progenitors (OPs) arise from distinct ventral and dorsal domains within the ventricular germinal zones of the embryonic CNS. The functional significance, if any, of these different populations is not known. Using dual-color reporter mice to distinguish ventrally and dorsally derived OPs, we show that, in response to focal demyelination of the young adult spinal cord or corpus callosum, dorsally derived OPs undergo enhanced proliferation, recruitment, and differentiation as compared with their ventral counterparts, making a proportionally larger contribution to remyelination. However, with increasing age (up to 13 months), the dorsally derived OPs become less able to differentiate into mature oligodendrocytes. Comparison of dorsally and ventrally derived OPs in culture revealed inherent differences in their migration and differentiation capacities. Therefore, the responsiveness of OPs to demyelination, their contribution to remyelination, and their susceptibility to age-associated functional decline are markedly dependent on their developmental site of origin in the developing neural tube. PMID:27149850

  2. Global signatures and dynamical origins of the Little Ice Age and Medieval Climate Anomaly.

    PubMed

    Mann, Michael E; Zhang, Zhihua; Rutherford, Scott; Bradley, Raymond S; Hughes, Malcolm K; Shindell, Drew; Ammann, Caspar; Faluvegi, Greg; Ni, Fenbiao

    2009-11-27

    Global temperatures are known to have varied over the past 1500 years, but the spatial patterns have remained poorly defined. We used a global climate proxy network to reconstruct surface temperature patterns over this interval. The Medieval period is found to display warmth that matches or exceeds that of the past decade in some regions, but which falls well below recent levels globally. This period is marked by a tendency for La Niña-like conditions in the tropical Pacific. The coldest temperatures of the Little Ice Age are observed over the interval 1400 to 1700 C.E., with greatest cooling over the extratropical Northern Hemisphere continents. The patterns of temperature change imply dynamical responses of climate to natural radiative forcing changes involving El Niño and the North Atlantic Oscillation-Arctic Oscillation.

  3. Age and origin of Cretaceous planktonic foraminifers from limestone of the Franciscan Complex near Laytonville, California

    USGS Publications Warehouse

    Sliter, W.V.; Premoli-Silva, I.

    1990-01-01

    Detailed planktonic foraminiferal biostratigraphy from eight measured sections of Cretaceous limestone near Laytonville, California, indicates a composite sequence that extends in age from late Albian to early Turonian. The sequence contains seven biozones and two subzones. Unequivocal biostratigraphic facing directions show four sections are right side up and four are reversed, and confirm the stratigraphic polarity employed in the paleomagnetic studies of Alvarez et al. (1980) and Tarduno et al. (1986). We propose that this complex of biogenic and lithogenic patterns records transit via oceanic plate motion from a depositional site in the southern part of the paleoequatorial zone of high productivity to the central part of the equatorial zone dominated by biogenic calcite deposition. -from Authors

  4. The origins of pure and applied science in Gilded Age America.

    PubMed

    Lucier, Paul

    2012-09-01

    "Pure science" and "applied science" have peculiar histories in the United States. Both terms were in use in the early part of the nineteenth century, but it was only in the last decades that they took on new meanings and became commonplace in the discourse of American scientists. The rise in their currency reflected an acute concern about the corruption of character and the real possibilities of commercializing scientific knowledge. "Pure" was the preference of scientists who wanted to emphasize their nonpecuniary motives and their distance from the marketplace. "Applied" was the choice of scientists who accepted patents and profits as other possible returns on their research. In general, the frequent conjoining of "pure" and "applied" bespoke the inseparable relations of science and capitalism in the Gilded Age. PMID:23286191

  5. Morphology, petrography, age and origin of Fogo Seamount chain, offshore eastern Canada

    NASA Astrophysics Data System (ADS)

    Pe-Piper, G.; de Jonge, A.; Piper, D. J. W.; Jansa, L. F.

    2003-04-01

    The Fogo Seamounts are located approximately 500 km offshore from Newfoundland to the southwest of the Grand Banks of Newfoundland. This complex seamount chain is early Cretaceous in age and is partially buried under later continental slope deposits. It has in the past been ascribed to the passage of a Canary or Azores hot spot. The seamounts are developed along the northeastern transform margin of the Jurassic central Atlantic Ocean. The Narwhal F-99 well was drilled in 1986 on the continental slope into one buried seamount. In this study, we bring together unpublished data on the bathymetry, seismic-reflection character, and distribution of the Fogo Seamounts and interpret new petrographic, geochemical, isotopic and geochronological data from a dredge sample from the central part of the seamount chain and from the Narwhal F-99 well, making comparisons with other offshore volcanic rocks on the eastern Canadian margin. Petrographically, the seamount samples consist of vitrophyric basalt, with clinopyroxene at Narwhal and kaersutite in the dredge sample. Chemically, the samples are olivine basalt with a low Mg number and low concentration of transition metals. Trace element and REE abundances are similar to those of other early Cretaceous volcanic rocks on the southeast Canadian margin. Three petrogenetic types of mafic magma are recognised in the area. The dredge sample is typical OIB rather alkalic basalts and similar to those in other seamount chains. Rocks at Narwhal and Brant have a greater signature of a depleted mantle source (are more tholeiitic). All have Nd isotopes similar to the Newfoundland and New England seamounts. In Orpheus graben to the northwest, there appears to have been greater crustal contamination, either from the crust in the region or from mantle previously enriched in crustal contaminants. The dredge sample gave a 40Ar/39Ar age of 130.3 +/- 1.3 Ma (Hauterivian). A K/Ar age from the Narwhal F-99 well of 127 +/- 6 Ma is inconsistent with

  6. The origins of pure and applied science in Gilded Age America.

    PubMed

    Lucier, Paul

    2012-09-01

    "Pure science" and "applied science" have peculiar histories in the United States. Both terms were in use in the early part of the nineteenth century, but it was only in the last decades that they took on new meanings and became commonplace in the discourse of American scientists. The rise in their currency reflected an acute concern about the corruption of character and the real possibilities of commercializing scientific knowledge. "Pure" was the preference of scientists who wanted to emphasize their nonpecuniary motives and their distance from the marketplace. "Applied" was the choice of scientists who accepted patents and profits as other possible returns on their research. In general, the frequent conjoining of "pure" and "applied" bespoke the inseparable relations of science and capitalism in the Gilded Age.

  7. The Origin and Age of Scallop Floodplain Benches from Difficult Run, Fairfax County, Virginia.

    NASA Astrophysics Data System (ADS)

    Scamardo, J. E.; Pizzuto, J. E.; Skalak, K.; Benthem, A.

    2015-12-01

    Sediment is deposited within scallop-shaped erosional scarps that form between trees armoring the banks of Difficult Run, a suburban watershed with a forested riparian zone. These deposits create small (surface area 85 m2, volume 300 m3), low-lying floodplain landforms this group terms Scallop Floodplain Benches (SFB). It is hypothesized that SFB formed within the past couple decades initially forming as transversal accretion deposits and eventually gaining floodplain features dominated by vertical accretion. Stratigraphic data supports that SFB deposits begin laterally as sand and gravel bars approximately 100 cm thick, and continue to grow by vertical accretion of sand, silt, and clay. As a SFB reaches its maximum height, a distinctive levee develops adjacent to the channel, and fine-grained silt and clay are deposited behind the levee. Core samples to a depth of 118 cm and additional samples from an overbank event that occurred on June 20, 2015 were collected from one of two SFB on Difficult Run near Leesburg Pike. The grain size distribution was measured using a Coulter Counter and activities of Pb-210, Cs-137, and Be-7 were measured using High Purity Germanium Detectors. Cs-137 activities are relatively constant with depth without a well-defined peak, suggesting that the SFB was deposited after 1963. Be-7 is present in the recent flood deposits, but is absent below the surface, suggesting that the SFB deposits are at least several years old. Excess Pb-210 activities decrease exponentially with depth, and can be fit using the Constant Rate of Supply method to determine an average age of approximately 13.5 years for the SFB. The SFB is storing sediment at a rate of 27 tons/year, which is equal to 0.35% of the annual sediment load of Difficult Run, based on this average age. SFB appear to be a significant component of the sediment storage of Difficult Run and therefore should be considered in the sediment budget.

  8. Magnetic Signature of the Lunar South Pole-Aitken Basin: Character, Origin, and Age

    NASA Technical Reports Server (NTRS)

    Purucker, Michael E.; Head, James W., III; Wilson, Lionel

    2012-01-01

    A new magnetic map of the Moon, based on Lunar Prospector (LP) magnetometer observations, sheds light on the origin of the South Pole-Aitken Basin (SPA), the largest and oldest of the recognized lunar basins. A set of WNW-trending linear to arcuate magnetic features, evident in both the radial and scalar observations, covers much of a 1000 km wide region centered on the NW portion of SPA. The source bodies are not at the surface because the magnetic features show no first-order correspondence to any surface topographic or structural feature. Patchy mare basalts of possible late Imbrianage are emplaced within SPA and are inferred to have been emplaced through dikes, directly from mantle sources. We infer that the magnetic features represent dike swarms that served as feeders for these mare basalts, as evident from the location of the Thomson/ Mare Ingenii, Van de Graaff, and Leeuwenhoek mare basalts on the two largest magnetic features in the region. Modeling suggests that the dike zone is between 25 and 50 km wide at the surface, and dike magnetization contrasts are in the range of 0.2 A/m. We theorize that the basaltic dikes were emplaced in the lunar crust when a long-lived dynamo was active. Based on pressure, temperature, and stress conditions prevalent in the lunar crust, dikes are expected to be a dominantly subsurface phenomenon, consistent with the observations reported here.

  9. Sensory Function: Insights From Wave 2 of the National Social Life, Health, and Aging Project

    PubMed Central

    Kern, David W.; Wroblewski, Kristen E.; Chen, Rachel C.; Schumm, L. Philip; McClintock, Martha K.

    2014-01-01

    Objectives. Sensory function, a critical component of quality of life, generally declines with age and influences health, physical activity, and social function. Sensory measures collected in Wave 2 of the National Social Life, Health, and Aging Project (NSHAP) survey focused on the personal impact of sensory function in the home environment and included: subjective assessment of vision, hearing, and touch, information on relevant home conditions and social sequelae as well as an improved objective assessment of odor detection. Method. Summary data were generated for each sensory category, stratified by age (62–90 years of age) and gender, with a focus on function in the home setting and the social consequences of sensory decrements in each modality. Results. Among both men and women, older age was associated with self-reported impairment of vision, hearing, and pleasantness of light touch. Compared with women, men reported significantly worse hearing and found light touch less appealing. There were no gender differences for vision. Overall, hearing loss seemed to have a greater impact on social function than did visual impairment. Discussion. Sensory function declines across age groups, with notable gender differences for hearing and light touch. Further analysis of sensory measures from NSHAP Wave 2 may provide important information on how sensory declines are related to health, social function, quality of life, morbidity, and mortality in this nationally representative sample of older adults. PMID:25360015

  10. A service life extension (SLEP) approach to operating aging aircraft beyond their original design lives

    NASA Astrophysics Data System (ADS)

    Pentz, Alan Carter

    With today's uncertain funding climate (including sequestration and continuing budget resolutions), decision makers face severe budgetary challenges to maintain dominance through all aspects of the Department of Defense (DoD). To meet war-fighting capabilities, the DoD continues to extend aircraft programs beyond their design service lives by up to ten years, and occasionally much more. The budget requires a new approach to traditional extension strategies (i.e., reuse, reset, and reclamation) for structural hardware. While extending service life without careful controls can present a safety concern, future operations planning does not consider how much risk is present when operating within sound structural principles. Traditional structural hardware extension methods drive increased costs. Decision makers often overlook the inherent damage tolerance and fatigue capability of structural components and rely on simple time- and flight-based cycle accumulation when determining aircraft retirement lives. This study demonstrates that decision makers should consider risk in addition to the current extension strategies. Through an evaluation of eight military aircraft programs and the application and simulation of F-18 turbine engine usage data, this dissertation shows that insight into actual aircraft mission data, consideration of fatigue capability, and service extension length are key factors to consider. Aircraft structural components, as well as many critical safety components and system designs, have a predefined level of conservatism and inherent damage tolerance. The methods applied in this study would apply to extensions of other critical structures such as bridges. Understanding how much damage tolerance is built into the design compared to the original design usage requirements presents the opportunity to manage systems based on risk. The study presents the sensitivity of these factors and recommends avenues for further research.

  11. The National Association of Industrial Technology: Origins and Leadership for the Future.

    ERIC Educational Resources Information Center

    Strong, Shawn; Kassapoglou, Michail; Dugger, John; Rudisill, Alvin

    1999-01-01

    Describes the following aspects of the National Association of Industrial Technology: purpose, objectives, membership, historical development, administrative organization, structure, and future directions. (SK)

  12. The active site of oxidative phosphorylation and the origin of hyperhomocysteinemia in aging and dementia.

    PubMed

    McCully, Kilmer S

    2015-01-01

    The active site of oxidative phosphorylation and adenosine triphosphate (ATP) synthesis in mitochondria is proposed to consist of two molecules of thioretinamide bound to cobalamin, forming thioretinaco, complexed with ozone, oxygen, nicotinamide adenine dinucleotide. and inorganic phosphate, TR2CoO3O2NAD(+)H2PO4(-). Reduction of the pyridinium nitrogen of the nicotinamide group by an electron from electron transport complexes initiates polymerization of phosphate with adenosine diphosphate, yielding nicotinamide riboside and ATP bound to thioretinaco ozonide oxygen. A second electron reduces oxygen to hydroperoxyl radical, releasing ATP from the active site. A proton gradient is created within F1F0 ATPase complexes of mitochondria by reaction of protons with reduced nicotinamide riboside and with hydroperoxyl radical, yielding reduced nicotinamide riboside and hydroperoxide. The hyperhomocysteinemia of aging and dementia is attributed to decreased synthesis of adenosyl methionine by thioretinaco ozonide and ATP, causing decreased allosteric activation of cystathionine synthase and decreased allosteric inhibition of methylenetetrahydrofolate reductase and resulting in dysregulation of methionine metabolism. PMID:25887881

  13. Geographic origins and dietary transitions during the Bronze Age in the Oman Peninsula.

    PubMed

    Gregoricka, Lesley A

    2013-11-01

    The nature of the Bronze Age transition from the Umm an-Nar (ca. 2700-2000 BC) to the Wadi Suq (ca. 2000-1300 BC) period in the Oman Peninsula has been highly debated by archaeologists, with some characterizing the latter as a time of cultural isolation, social collapse, and/or population replacement following the successful involvement of the area in widespread interregional exchange networks across Arabia and South Asia. The hypothesis that a substantial change in residential mobility, immigration, and diet took place in response to considerable societal changes as reflected by the archaeological record was tested using stable oxygen and carbon isotope analysis. Archaeological human dental enamel from individuals interred in six Umm an-Nar (n = 100) and seven Wadi Suq (n = 16) communal tombs in the United Arab Emirates was used. Oxygen isotope data reveal largely homogeneous ratios indicative of a predominantly local population that acquired water from isotopically similar sources, although the presence of immigrants during both periods suggests that the region was not as isolated as previously held. Carbon isotope data exhibit a substantial temporal shift from an extremely varied to a more restricted diet, demonstrating that while considerable changes in subsistence strategies and social organization took place in the early second millennium BC, population continuity and sustained (although lessened) participation in pan-Gulf trade systems best characterizes this regional transformation. PMID:24104555

  14. The age and origin of felsic intrusions of the Thetford Mines ophiolite, Quebec.

    USGS Publications Warehouse

    Clague, D.A.; Frankel, C.S.; Eaby, J.S.

    1985-01-01

    This ophiolite was obducted in the early Ordovician during the closing of the proto-Atlantic. The tectonized peridotite of the lower unit of the ophiolite is intruded by felsic dykes and pods, including isolated lenses of massive rodingite, small bodies of strongly deformed diorite, and younger, less deformed monzonite. These intrusions are found only near the base of the ophiolite, and are considered to have been emplaced before the ophiolite reached its present position. The young group of intrusions consists of biotite-muscovite quartz monzonite and leuco-quartz monzonite. Analysed samples have high K2O, high (K2O X 100)/Na2O + K2O) ratios, and high initial Sr ratios, indicating that the magma source was continental and that these felsic rocks formed by partial melting of continental sediments. Whole-rock and mineral isochron ages suggest that the felsic intrusions are approx 456 + or - 4 m.y. old and that they were metamorphosed approx 418 + or - 7 m.y. ago. The detachment of the ophiolite occurred approx 491 + or - 3 m.y. ago. The felsic dykes were intruded approx 35 m.y. later, during the Taconic orogeny. The lengthy time between detachment and final nappe emplacement recorded by the felsic dykes may be a requirement for formation of abundant asbestiform chrysotile. Whole-rock analyses (16) and Rb, Sr and 87Sr/86Sr data from the Colline de Granite, King Mts., Vimy Ridge and Black Lake samples are presented.-P.Br.

  15. Bayesian phylogenetic analysis of Semitic languages identifies an Early Bronze Age origin of Semitic in the Near East

    PubMed Central

    Kitchen, Andrew; Ehret, Christopher; Assefa, Shiferaw; Mulligan, Connie J.

    2009-01-01

    The evolution of languages provides a unique opportunity to study human population history. The origin of Semitic and the nature of dispersals by Semitic-speaking populations are of great importance to our understanding of the ancient history of the Middle East and Horn of Africa. Semitic populations are associated with the oldest written languages and urban civilizations in the region, which gave rise to some of the world's first major religious and literary traditions. In this study, we employ Bayesian computational phylogenetic techniques recently developed in evolutionary biology to analyse Semitic lexical data by modelling language evolution and explicitly testing alternative hypotheses of Semitic history. We implement a relaxed linguistic clock to date language divergences and use epigraphic evidence for the sampling dates of extinct Semitic languages to calibrate the rate of language evolution. Our statistical tests of alternative Semitic histories support an initial divergence of Akkadian from ancestral Semitic over competing hypotheses (e.g. an African origin of Semitic). We estimate an Early Bronze Age origin for Semitic approximately 5750 years ago in the Levant, and further propose that contemporary Ethiosemitic languages of Africa reflect a single introduction of early Ethiosemitic from southern Arabia approximately 2800 years ago. PMID:19403539

  16. Workplace, age, and sex as mediators of olfactory function: data from the National Geographic Smell Survey.

    PubMed

    Corwin, J; Loury, M; Gilbert, A N

    1995-07-01

    Certain medications and environmental agents are known to adversely affect chemosensation. We report data from 712,000 respondents aged 20 to 79 to the National Geographic Smell Survey that suggest that exposure to the factory workplace adversely affects the sense of smell, and that these effects interact with age. Men and women with histories of factory work reported poorer senses of smell relative to other workers. They also demonstrated objective evidence of greater impairment in odor detection. These effects were greater for men. Factory workers of all ages more frequently reported olfactory loss secondary to chemical exposure and head injury than did workers in other environments. The highest relative risk of olfactory problems secondary to head injury was in the oldest women factory workers. Thus, olfaction may behave as other senses do: Age, sex, and exposure to noxious events or agents interact to produce sensory deficits. PMID:7606529

  17. Origin and age of the earliest Martian crust from meteorite NWA 7533.

    PubMed

    Humayun, M; Nemchin, A; Zanda, B; Hewins, R H; Grange, M; Kennedy, A; Lorand, J-P; Göpel, C; Fieni, C; Pont, S; Deldicque, D

    2013-11-28

    The ancient cratered terrain of the southern highlands of Mars is thought to hold clues to the planet's early differentiation, but until now no meteoritic regolith breccias have been recovered from Mars. Here we show that the meteorite Northwest Africa (NWA) 7533 (paired with meteorite NWA 7034) is a polymict breccia consisting of a fine-grained interclast matrix containing clasts of igneous-textured rocks and fine-grained clast-laden impact melt rocks. High abundances of meteoritic siderophiles (for example nickel and iridium) found throughout the rock reach a level in the fine-grained portions equivalent to 5 per cent CI chondritic input, which is comparable to the highest levels found in lunar breccias. Furthermore, analyses of three leucocratic monzonite clasts show a correlation between nickel, iridium and magnesium consistent with differentiation from impact melts. Compositionally, all the fine-grained material is alkalic basalt, chemically identical (except for sulphur, chlorine and zinc) to soils from Gusev crater. Thus, we propose that NWA 7533 is a Martian regolith breccia. It contains zircons for which we measured an age of 4,428 ± 25 million years, which were later disturbed 1,712 ± 85 million years ago. This evidence for early crustal differentiation implies that the Martian crust, and its volatile inventory, formed in about the first 100 million years of Martian history, coeval with earliest crust formation on the Moon and the Earth. In addition, incompatible element abundances in clast-laden impact melt rocks and interclast matrix provide a geochemical estimate of the average thickness of the Martian crust (50 kilometres) comparable to that estimated geophysically. PMID:24256724

  18. Origin and age of the Eisenkappel gabbro to granite suite (Carinthia, SE Austrian Alps)

    PubMed Central

    Miller, C.; Thöni, M.; Goessler, W.; Tessadri, R.

    2011-01-01

    The northern part of the Karawanken plutonic belt is a gabbro–granite complex located just north of the Periadriatic lineament near the Slovenian–Austrian border. Petrographic and geochemical studies of the Eisenkappel intrusive complex indicate that this multiphase plutonic suite developed by a combination of crystal accumulation, fractional crystallization and assimilation processes, magma mixing and mingling. The mafic rocks are alkaline and have within-plate geochemical characteristics, indicating anorogenic magmatism in an extensional setting and derivation from an enriched mantle source. The mafic melts triggered partial melting of the crust and the formation of granite. The granitic rocks are alkalic, metaluminous and have the high Fe/Fe + Mg characteristics of within-plate plutons. Temperature and pressure conditions, derived from amphibole-plagioclase and different amphibole thermobarometers, suggest that the analysed Eisenkappel gabbros crystallized at around 1000 ± 20 °C and 380–470 MPa, whereas the granitic rock crystallized at T ≤ 800 ± 20 °C and ≤ 350 MPa. Mineral-whole rock Sm–Nd analyses of two cumulate gabbros yielded 249 ± 8.4 Ma and 250 ± 26 Ma (εNd: + 3.6), garnet-whole rock Sm–Nd analyses of two silicic samples yielded well-constrained ages of 238.4 ± 1.9 Ma and 242.1 ± 2.1 Ma (εNd: − 2.6). PMID:26525511

  19. Origin and age of the earliest Martian crust from meteorite NWA 7533.

    PubMed

    Humayun, M; Nemchin, A; Zanda, B; Hewins, R H; Grange, M; Kennedy, A; Lorand, J-P; Göpel, C; Fieni, C; Pont, S; Deldicque, D

    2013-11-28

    The ancient cratered terrain of the southern highlands of Mars is thought to hold clues to the planet's early differentiation, but until now no meteoritic regolith breccias have been recovered from Mars. Here we show that the meteorite Northwest Africa (NWA) 7533 (paired with meteorite NWA 7034) is a polymict breccia consisting of a fine-grained interclast matrix containing clasts of igneous-textured rocks and fine-grained clast-laden impact melt rocks. High abundances of meteoritic siderophiles (for example nickel and iridium) found throughout the rock reach a level in the fine-grained portions equivalent to 5 per cent CI chondritic input, which is comparable to the highest levels found in lunar breccias. Furthermore, analyses of three leucocratic monzonite clasts show a correlation between nickel, iridium and magnesium consistent with differentiation from impact melts. Compositionally, all the fine-grained material is alkalic basalt, chemically identical (except for sulphur, chlorine and zinc) to soils from Gusev crater. Thus, we propose that NWA 7533 is a Martian regolith breccia. It contains zircons for which we measured an age of 4,428 ± 25 million years, which were later disturbed 1,712 ± 85 million years ago. This evidence for early crustal differentiation implies that the Martian crust, and its volatile inventory, formed in about the first 100 million years of Martian history, coeval with earliest crust formation on the Moon and the Earth. In addition, incompatible element abundances in clast-laden impact melt rocks and interclast matrix provide a geochemical estimate of the average thickness of the Martian crust (50 kilometres) comparable to that estimated geophysically.

  20. Age constraints on late Mesozoic lithospheric extension and origin of bimodal volcanic rocks from the Hailar basin, NE China

    NASA Astrophysics Data System (ADS)

    Li, Shuang-Qing; Hegner, Ernst; Yang, Yi-Zeng; Wu, Jia-De; Chen, Fukun

    2014-03-01

    Following the amalgamation of the late Mesoproterozoic-Carboniferous Central Asian Orogenic Belt with the Siberian and North China cratons, NE China underwent late Mesozoic lithospheric extension and widespread formation of volcano-sedimentary basins. We report U-Pb zircon ages and geochemical data for mafic and felsic volcanic rocks from the Hailar basin, located about 1000 km north of Beijing. Zircon populations of six felsic rock samples analyzed by laser ablation ICP-MS yielded similar U-Pb age spectra ranging from 158 to 125 Ma. The youngest zircon ages are interpreted as time of magma eruption and the xenocrystic zircon-age spectra as evidence for a protracted melting of lower crust due to the underplating of mantle-derived magmas during lithospheric extension. The volcanic assemblage has a bimodal composition comprising geochemically evolved trachybasalts and felsic volcanic rocks of I- and subordinate A-type compositions. The mafic volcanic rocks have negative Nb-anomalies, high Th/Nb and Ce/Pb ratios, low initial ɛNd values of + 0.4 to + 3.4, and radiogenic Pb and Sr isotopes all interpreted as evidence for the melting of passively upwelling asthenosphere and lithospheric mantle previously modified by plate subduction. The xenocrystic zircon ages and chemical/isotopic data of the felsic rocks support an origin from juvenile crustal protoliths: the data of I-type felsic rocks are consistent with the melting of underplated mafic protoliths and those of the A-type rhyolites support the melting of a crustal source with a composition similar to the I-type felsites with apatite controlling their Nb anomaly. The evidence for the persistent melting of a subduction-modified mantle in NE China is in agreement with a model of an extending coupled upper mantle-crust system due to a retreating Paleo-Pacific trench.

  1. Age and origin of Terra Rossa soils in the Coonawarra area of South Australia

    NASA Astrophysics Data System (ADS)

    Mee, Aija C.; Bestland, Erick A.; Spooner, Nigel A.

    2004-03-01

    The famous Terra Rossa soil in the Coonawarra area, South Australia, is dominated by locally derived aeolian detritus, which probably accumulated over the last 120-130 ka. Four soil profiles and associated limestone and lunette deposits were investigated using the following methods: mass balance geochemistry of bulk soil samples (major and trace elements), quantitative X-ray diffraction (XRD) mineralogy, strontium isotopes (87/86), as well as grain-size analysis and cation exchange capacity. These data show that the Terra Rossa soil from the Coonawarra has a thick, clayey B-horizon which is geochemically homogeneous and dominated by smectite and kaolinite. Mass-balance calculations show unrealistic weathering scenarios when plotted using silicate residuum from the underlying limestone as parent. Realistic weathering scenarios are produced with fine-grained silicate material from local lunette deposits as parent. Strontium isotopes of silicate residuum from Gambier Limestone (0.78) contrast strongly with the clayey B-horizon (0.726). Strontium isotope ratios of silicate material from a local lunette (0.725) are similar to the B-horizon soil values. Strontium isotope ratios from regional geological units indicate that the strontium signature in the lunette and soil B-horizon is dominated by weathering products from the Palaeozoic Kanmantoo shales, extensively exposed upwind to the west on Kangaroo Island and the Fleurieu Peninsula. Optical (optically stimulated luminescence, OSL) dating of 61 individual quartz grains (single aliquot) from three samples in the Coonawarra soil profile (one from the A-horizon and two from the B-horizon) shows that most of the quartz sand grains have been buried for only a few thousand years. Many of the grains, however, have been buried for tens of thousands of years with three grains having exposure ages of between 105 and 109 ka. The large population of young exposure dates represents quartz sands recently exposed in the A-horizon and

  2. Origin, Age, and Geochemistry of the Tuff of Saguache Creek, Southwestern Colorado

    NASA Astrophysics Data System (ADS)

    Turner, K. J.; Young, M. D.; Wendlandt, R. F.

    2003-12-01

    A crystal-poor, rhyolitic, ash-flow tuff in the Eastern San Juan Volcanic Field currently known as the tuff of Saguache Creek (TSC) was reinterpreted by Simon and Wendlandt (1999) as not being distal Sapinero Mesa Tuff. Currently there is no source caldera established for this tuff thereby leaving uncertainties in the volcanic history. Regional mapping of the TSC has subsequently been completed to constrain a possible source caldera. Petrographic studies, and EPMA and LA-ICPMS analyses of the mineral assemblage have been performed to characterize further the tuff, enable correlation of mapped TSC, and constrain petrogenetic models. Petrographic and chemical identification of the TSC builds on characteristics set forth by Simon (2000). These characteristics include abundant feldspar clusters, alkali feldspar mantled plagioclase, no modal quartz, Fe-Ti oxides (often with apatites and zircons), and sparse biotite and pyroxene. Pyroxenes show curiously high MnO (avg 2.70 wt%) and Mg# (avg 79.2) and might be xenocrystic. In comparison, biotites have much lower MnO (avg 0.82 wt%). Average sanidine (Or50) and plagioclase (Ab71) compositions fall within the documented range (Simon, 2000) and show little trace element substitution including Eu <3 ppm and Ba <1200 ppm. Titanites are enriched in Ce (17,000-20,000 ppm) and Pr (2,200-2700 ppm). Apatites show similar enrichment in Ce (2200-7600 ppm) and Pr (330-350 ppm). Confirmed outcrops of TSC are best preserved just north of Trickle Mtn where it is approximately 30 m thick and overlain by a welded airfall ash deposit preliminarily dated at 29-30 Ma. Outcrop localities south of Colorado Highway 114 show thinning and are interpreted as erosional remnants plastered on older Conejos age volcanic deposits. Similarly, an andesitic topographic high just west of Trickle Mtn has TSC vitrophyre on the east-facing slope suggesting strong north-south channeling of the flow unit by paleo-topographic lows. Outcrop elevations also decrease

  3. Thermal and tectonic evolution of the central and southern Appalachians: evidence from distribution, age, and origin of granitic rocks

    SciTech Connect

    Sinha, A.K.; Guy, R.; Hund, E.; Tamburro, E.

    1985-01-01

    The distribution and resolution of thermal events and associated igneous activity can discriminate between tectonic processes that form orogenic terrains, i.e., accretion of terranes, overthrusting of terranes versus thrust stacking within terranes. Reinterpretation of regional tectonics (Higgins et al., 1984) coupled with the authors interpretation of the age, origin, and distribution of granitic rocks suggest a very different mechanism for the evolution of the central and southern Appalachian orogenic belt. The Cambro-Ordovician magmatic arc (weakly bimodal) separated from the North American Margin by a Back arc basin, was thrust over the North American plate margin during the middle Ordovician. The Avalon terrane (Little River allochthon of Higgins et al., 1984) arrived during the late Silurian - but unlike earlier models that require subduction zone related with its arrival, the authors postulate strike-slip tectonics. The gabbro-diorite-syenite association in the Charlotte belt (Macon melange of Higgins) is probably related to grabens associated with the strike-slip accretion. Rocks of similar age (Siluro-Devonian) in the present day Blue Ridge and Inner Piedmont blocks are related to decompressional melting after the Ordovician thrusting. The high pressure metamorphism and associated melting show a range in ages indicating variations in uplift rates or thickness of the crust caused by the initial overthrusting, and do not require a discrete subduction or orogenic event. The Permo-Carboniferous igneous activity, and associated uplift and thrusting with a strike-slip component are related to oblique subduction and post-subduction collision processes.

  4. On the origin of brucellosis in bison of Yellowstone National Park: a review

    USGS Publications Warehouse

    Meagher, Mary; Meyer, Margaret E.

    1994-01-01

    Brucellosis caused by Brucella abortus occurs in the free-ranging bison (Bison bison) of Yellowstone and Wood Buffalo National Parks and in elk (Cervus elaphus) of the Greater Yellowstone Area. As a result of nationwide bovine brucellosis eradication programs, states and provinces proximate to the national parks are considered free of bovine brucellosis. Thus, increased attention has been focused on the wildlife within these areas as potential reservoirs for transmission to cattle. Because the national parks are mandated as natural areas, the question has been raised as to whether Brucella abortus is endogenous or exogenous to bison, particularly for Yellowstone National Park. We synthesized diverse lines of inquiry, including the evolutionary history of both bison and Brucella, wild animals as Brucella hosts, biochemical and genetic information, behavioral characteristics of host and organism, and area history to develop an evaluation of the question for the National Park Service. All lines of inquiry indicated that the organism was introduced to North America with cattle, and that the introduction into the Yellowstone bison probably was directly from cattle shortly before 1917. Fistulous withers of horses was a less likely possibility. Elk on winter feedgrounds south of Yellowstone National Park apparently acquired the disease directly from cattle. Bison presently using Grand Teton National Park probably acquired brucellosis from feedground elk.

  5. Age and origin of the Lomonosov Ridge: a key continental fragment in Arctic Ocean reconstructions

    NASA Astrophysics Data System (ADS)

    Marcussen, Christian; Knudsen, Christian; Hopper, John R.; Funck, Thomas; Ineson, Jon R.; Bjerager, Morten

    2015-04-01

    The Lomonosov Ridge is a trans-oceanic seafloor high that separates the Eurasia Basin from the Amerasia Basin. It extends for a distance of almost 1800 km across the Arctic Ocean from the Lincoln Shelf off Greenland and Canada to the East Siberian Shelf. Although known from the ACEX drilling expedition to be a sliver of continental crust, it remains an enigmatic feature and many details of its history are unknown. In the summer of 2012, GEUS recovered dredge samples from two locations along the flank of the ridge facing the Eurasian Basin. The samples comprise 100 kg and 200 kg of rocks and rock pieces ranging in size from 0.1 to 80 kg which were recovered from two different scarps associated with rotated continental fault blocks. A significant quantity of rocks with identical structures and isotopic fingerprints show that they formed at the same time and from the same geological material. This combined with the broken and angular nature of many of the pieces recovered indicates that the material is from in situ bedrock and does not represent dropstones brought to the area by drifting ice. Two main sedimentary rock types were recovered - an arkosic metasedimentary rock, and a quartz rich non-metamorphic sandstone. The arkosic metasedimentary rock shows compositional layering (primary heterolithic fabric) that is deformed and with a well-developed schistosity. These metasedimentary rocks contain muscovite with textural evidence that shows the muscovite is metamorphic and not detrital, and thus formed at the time the rocks were deformed. The metamorphic fabrics and mineralogy indicate deformation under greenschist facies conditions, indicating that the metamorphism was associated with an orogenic event; the metamorphic muscovite has yielded an Ar/Ar age of around 470 Ma. Thus the rock is interpreted as a Proterozoic to lower Palaeozoic heterolithic sandstone that was involved in an orogenic event during the Ordovician. This event may be related to the Mid

  6. Finger patterns and age of onset for the determination of the parent-of-origin in the transmission of schizophrenia

    PubMed Central

    Ponnudurai, R.; Jayakar, J.

    2015-01-01

    Summary: Dermatoglyphic traits which are reported to be largely determined by genes could be considered as phenotypic characterestics and if the same are expressed through generations in schizophrenic families it can be speculated to serve as genetic markers for schizophrenia. Another factor that might be influenced by genes is the age of onset of the illness in the offspring and the parent of origin. Objective: This study was aimed to elucidate the occurrence of identical finger patterns in the schizophrenic patients and their affected parents. The other objective was to assess the age of onset of the illness in them. Methods: Forty six schizophrenic patients in whom one of the parents was also affected with schizophrenia or related disorders were recruited. Of these pairs 29 were taken up for finger patterns analysis, with an equal number of control group pairs. 35 proband and parent pairs were investigated for the age of onset of the illness. Results: The frequency of occurrence of identical patterns in the right thumbs of proband and their affected mother pairs was significantly more than between the proband and their affected father pairs. Additionally, the number of identical patterns was also more in the right thumbs of proband and their affected mother pairs compared with the control group. The difference between the mean age of onset of the illness in the probands and their affected fathers was more than between the probands and their affected mothers. Conclusion: The genetic association of schizophrenic patients with the affected maternal side appear to be more stronger than with the paternal side. PMID:25657454

  7. Constraining the age and origin of the seamount province in the Northeast Indian Ocean using geophysical techniques

    NASA Astrophysics Data System (ADS)

    Taneja, Rajat; O'Neill, Craig

    2014-12-01

    The breakup of western margin of Australia from Greater India started around 155 Ma and progressed southwards. After the separation, the interceding intraplate region experienced large volumes of submarine volcanism, extending over 100 Myrs. The Christmas Island Seamount Province (CHRISP, as it has been dubbed) lies south of the Java-Sunda Trench, and contains numerous submerged volcanic seamounts, and two sub-aerially exposed island groups—Cocos (Keeling) Islands, and Christmas Island. While recent geochronological investigations have shed light on the diverse eruption ages of the volcanics of this region, some islands/seamounts have demonstrated protracted volcanic histories, and it is not clear how the volcanic loading, tectonic subsidence, and subsequent emergence history of the islands relates to these discrete volcanic episodes. This study utilises a number of geophysical techniques to determine the crustal structure, loading and subsidence history, and last sub-aerial exposure age for the CHRISP. The study shows that flexural and subsidence modelling are reliable techniques in constraining the age of the seamounts when geochronological techniques are not possible. Utilising regional gravity signatures, we model the crustal structure underneath the Cocos (Keeling) Island, and constrain the thickness of the limestone cover between 900 and 2,100 m. Using age-depth subsidence curves for oceanic lithosphere the time since these seamounts were exposed above sea-level was determined, and a trend in exposure ages that youngs towards the west is observed. Two episodes of volcanism have been recorded at Christmas Island and they are of different origin. The younger phase in the Pliocene is a manifestation of flexure induced cracks produced in the lithosphere as it rides the subduction fore-bulge, whereas a low velocity seismic zone rising from the lower mantle, and tectonic reorganization, may be associated with the older Eocene volcanic phase, as well as much of

  8. Post-retrieval effects of icv infusions of hemicholinium in mice are dependent on the age of the original memory.

    PubMed

    Boccia, Mariano M; Blake, Mariano G; Acosta, Gabriela B; Baratti, Carlos M

    2006-01-01

    CF-1 male mice were trained in an inhibitory avoidance task using a high footshock (1,2 mA, 50 Hz, 1 sec) in order to reduce the influence of extinction on retention performance. At 2, 7, 14, or 30 d after training, the first retention test was performed and hemicholinium (HC-3, 1.0 microg/mice), a specific inhibitor of high-affinity choline uptake in brain cholinergic neurons, was given intracerebroventricularly immediately after. Twenty four hours after treatment, mice were tested in an inhibitory avoidance task during five consecutive days, each 24 h apart. Retention performance was impaired by HC-3 when the first re-exposure took place at 2, 7, or 14 d, but the effect was no longer seen when re-exposure occurred 30 d after training. We did not find spontaneous recovery 21 d after training, when memory was retrieved 2 d after training and HC-3 was given immediately after. Although we cannot definitively discard a retrieval deficit, this lack of spontaneous recovery is in accordance with the storage-deficit interpretation. These results confirm and extend previous ones, suggesting that central cholinergic mechanisms are involved in the hypothetical reconsolidation memory processes of an inhibitory avoidance task in mice and also suggest that this participation depends on the "age" of the original memory trace. This implies that the vulnerability of a reactivated memory to a specific treatment, as the one used in this study, inversely correlates with the age of the original memory, and it is likely to determine memory reconsolidation processes. PMID:16741287

  9. Post-retrieval effects of icv infusions of hemicholinium in mice are dependent on the age of the original memory.

    PubMed

    Boccia, Mariano M; Blake, Mariano G; Acosta, Gabriela B; Baratti, Carlos M

    2006-01-01

    CF-1 male mice were trained in an inhibitory avoidance task using a high footshock (1,2 mA, 50 Hz, 1 sec) in order to reduce the influence of extinction on retention performance. At 2, 7, 14, or 30 d after training, the first retention test was performed and hemicholinium (HC-3, 1.0 microg/mice), a specific inhibitor of high-affinity choline uptake in brain cholinergic neurons, was given intracerebroventricularly immediately after. Twenty four hours after treatment, mice were tested in an inhibitory avoidance task during five consecutive days, each 24 h apart. Retention performance was impaired by HC-3 when the first re-exposure took place at 2, 7, or 14 d, but the effect was no longer seen when re-exposure occurred 30 d after training. We did not find spontaneous recovery 21 d after training, when memory was retrieved 2 d after training and HC-3 was given immediately after. Although we cannot definitively discard a retrieval deficit, this lack of spontaneous recovery is in accordance with the storage-deficit interpretation. These results confirm and extend previous ones, suggesting that central cholinergic mechanisms are involved in the hypothetical reconsolidation memory processes of an inhibitory avoidance task in mice and also suggest that this participation depends on the "age" of the original memory trace. This implies that the vulnerability of a reactivated memory to a specific treatment, as the one used in this study, inversely correlates with the age of the original memory, and it is likely to determine memory reconsolidation processes.

  10. Age, field, and petrological relationships of the Hyde School Gneiss, Adirondack lowlands, New York: Criteria for an intrusive igneous origin

    SciTech Connect

    McLelland, J. ); Perham, A. ); Chiarenzelli, J.

    1992-01-01

    Alaskitic and tonalitic rocks constituting Hyde School Gneiss (HSG) occur in 14 domical bodies in the Adirondack lowlands. Recent models have interpreted these bodies as metamorphosed rhyolitic and dacitic ash-flow deposits forming the basal member of a regional stratigraphic package. In contrast, this paper presents criteria and evidence for an intrusive origin for HSG. Field evidence includes intrusion breccias and complex crosscutting relationships involving mafic layers resembling synplutonic dikes. Petrologic constraints supporting an intrusive origin include: (1) the common occurrence of quartz-mesoperthite hypersolvus assemblages; (2) magmatic features in tonalitic, trondhjemitic, and alaskitic facies, (3) local occurrences of orthopyroxene in all facies of HSG; and (4) the development of marginal garnet-sillimanite gneiss with corundum-spinel-garnet-sillimanite assemblages yielding paleotemperatures of 780-810C and interpreted as restite remaining after anatexis of country rock metapelite by intrusions of hypersolvus granitoids. U-Pb zircon ages reported here suggest that the majority of the HSG was intruded at ca. 1230 Ma, contemporaneous with high-grade metamorphic activity in the Adirondacks and elsewhere in the SW sector of the Grenville Province. Geochronological evidence from a leucogranitic rock crosscutting metasediments on Wellesley Island suggest that these metasediments are older than 1416 {plus minus} 5 Ma.

  11. Olfactory Function in Wave 2 of the National Social Life, Health, and Aging Project

    PubMed Central

    Wroblewski, Kristen E.; Schumm, L. Philip; Pinto, Jayant M.; Chen, Rachel C.; McClintock, Martha K.

    2014-01-01

    Objective. To investigate the sense of smell, including sensitivity and odor identification, and characterize the U.S. national prevalence of olfactory dysfunction in older adults, thereby facilitating further investigation of the substantial risks for older adults associated with this basic sensory ability. Method. The sense of smell was evaluated using the Olfactory Function Field Exam (OFFE), a measure designed specifically for field research, which assesses 3 components of olfaction: sensitivity to n-butanol (a standard testing odorant) and androstadienone (AND, a key social odor produced by humans), as well as the ability to identify odors. Respondents were randomly selected from the National Social Life, Health, and Aging Project Wave 2 sample to receive the OFFE (n = 2,304), and 2,212 consented to participate. Results. In the U.S. population aged 62–90, n-butanol detection ability was significantly worse at older ages (ordinal logistic regression, p < .001); however, there was no difference in detection ability between genders (p = .60). AND detection ability was also significantly worse at older ages (p = .003), but in contrast to n-butanol, women outperformed men (p = .001). As expected, odor identification ability was worse in older people than in younger (p < .001), and women were more accurate than men (p = .001). Discussion. We report for the first time 3 facets of olfactory function and its association with age and gender in a representative sample of U.S. older adults. Future analyses of these data are needed to elucidate the sense of smell’s role in physical, social, and mental health with aging. PMID:25360014

  12. White House Conference on Aging (Washington, D.C., November 30-December 3, 1981). Final Report. Volume 1: A National Policy on Aging.

    ERIC Educational Resources Information Center

    White House Conference on Aging, Washington, DC.

    This first volume of three of the final report of the 1981 White House Conference on Aging contains the response to the congressional charge to the Conference that the final report propose a national policy on aging not only for the minority who need aid but also for the majority of older adults who live in comfort and security. The report is…

  13. National Vocational Qualifications in the United Kingdom: Their Origins and Legacy

    ERIC Educational Resources Information Center

    Young, Michael

    2011-01-01

    National Vocational Qualifications (NVQs) were launched in the United Kingdom (excluding Scotland) in 1987 as a framework for rationalising what was described at the time as the "jungle" of existing vocational qualifications. They were never intended to be the basis for a comprehensive NQF for all qualifications; however, successive governments…

  14. The Origins and Development of the National Training Center, 1976-1984. TRADOC Historical Monograph Series.

    ERIC Educational Resources Information Center

    Chapman, Anne W.

    Focusing on the development of the United States Army's National Training Center (NTC) from conceptualization and initial implementation in 1981 to the end of the first phase of development in 1984, this monograph provides a documented historical analysis of how and why the landmark event in army training was launched and examines attendant policy…

  15. National Curriculum Reform in China and England: Origins, Character and Comparison

    ERIC Educational Resources Information Center

    Halpin, David

    2010-01-01

    Both China and England require state-funded schools to teach a national curriculum. While policy congruence in terms of overall intention is apparent, there are major differences between each country's approach to systemic curriculum reform which highlight contrasting attitudes to how best to effect change in schools and widely differing views on…

  16. Strong Components of Epigenetic Memory in Cultured Human Fibroblasts Related to Site of Origin and Donor Age

    PubMed Central

    Ivanov, Nikolay A.; Tao, Ran; Chenoweth, Joshua G.; Brandtjen, Anna; Mighdoll, Michelle I.; Genova, John D.; McKay, Ronald D.; Jia, Yankai; Weinberger, Daniel R.; Kleinman, Joel E.; Hyde, Thomas M.; Jaffe, Andrew E.

    2016-01-01

    Differentiating pluripotent cells from fibroblast progenitors is a potentially transformative tool in personalized medicine. We previously identified relatively greater success culturing dura-derived fibroblasts than scalp-derived fibroblasts from postmortem tissue. We hypothesized that these differences in culture success were related to epigenetic differences between the cultured fibroblasts by sampling location, and therefore generated genome-wide DNA methylation and transcriptome data on 11 intrinsically matched pairs of dural and scalp fibroblasts from donors across the lifespan (infant to 85 years). While these cultured fibroblasts were several generations removed from the primary tissue and morphologically indistinguishable, we found widespread epigenetic differences by sampling location at the single CpG (N = 101,989), region (N = 697), “block” (N = 243), and global spatial scales suggesting a strong epigenetic memory of original fibroblast location. Furthermore, many of these epigenetic differences manifested in the transcriptome, particularly at the region-level. We further identified 7,265 CpGs and 11 regions showing significant epigenetic memory related to the age of the donor, as well as an overall increased epigenetic variability, preferentially in scalp-derived fibroblasts—83% of loci were more variable in scalp, hypothesized to result from cumulative exposure to environmental stimuli in the primary tissue. By integrating publicly available DNA methylation datasets on individual cell populations in blood and brain, we identified significantly increased inter-individual variability in our scalp- and other skin-derived fibroblasts on a similar scale as epigenetic differences between different lineages of blood cells. Lastly, these epigenetic differences did not appear to be driven by somatic mutation—while we identified 64 probable de-novo variants across the 11 subjects, there was no association between mutation burden and age of the donor (p

  17. Rates of stillbirth by gestational age and cause in Inuit and First Nations populations in Quebec

    PubMed Central

    Auger, Nathalie; Park, Alison L.; Zoungrana, Hamado; McHugh, Nancy Gros-Louis; Luo, Zhong-Cheng

    2013-01-01

    Background: Inuit and First Nations populations have higher rates of stillbirth than non-Aboriginal populations in Canada do, but little is known about the timing and cause of stillbirth in Aboriginal populations. We compared gestational age– and cause-specific stillbirth rates in Inuit and First Nations populations with the rates in the non-Aboriginal population in Quebec. Methods: Data included singleton stillbirths and live births at 24 or more gestational weeks among Quebec residents from 1981 to 2009. We calculated odds ratios (ORs), rate differences and 95% confidence intervals (CIs) for the retrospective cohort of Inuit and First Nations births relative to non-Aboriginal births using fetuses at risk (i.e., ongoing pregnancies) as denominators and adjusting for maternal characteristics. The main outcomes were stillbirth by gestational age (24–27, 28–36, ≥ 37 wk) and cause of death. Results: Rates of stillbirth per 1000 births were greater among Inuit (6.8) and First Nations (5.7) than among non-Aboriginal (3.6) residents. Relative to the non-Aboriginal population, the risk of stillbirth was greater at term (≥ 37 wk) than before term for both Inuit (OR 3.1, 95% CI 1.9 to 4.8) and First Nations (OR 2.6, 95% CI 2.1 to 3.3) populations. Causes most strongly associated with stillbirth were poor fetal growth, placental disorders and congenital anomalies among the Inuit, and hypertension and diabetes among the First Nations residents. Interpretation: Stillbirth rates in Aboriginal populations were particularly high at term gestation. Poor fetal growth, placental disorders and congenital anomalies were important causes of stillbirth among the Inuit, and diabetic and hypertensive complications were important causes in the First Nations population. Prevention may require improvements in pregnancy and obstetric care. PMID:23422443

  18. Sexuality and Physical Contact in National Social Life, Health, and Aging Project Wave 2

    PubMed Central

    McClintock, Martha K.; Waite, Linda J.

    2014-01-01

    Introduction. Wave 2 of the National Social Life, Health, and Aging Project (NSHAP) includes new measures of sexual interest and behavior, as well as new measures of the context of sexual experience and the frequency and appeal of physical contact. This is the first time many of these constructs have been measured in a nationally representative sample. Method. We describe the new measures and compare the distributions of each across gender and age groups, in some cases by partnership status. Results. Two components of sexuality decrease with age among both men and women: frequency of finding an unknown person sexually attractive and receptivity to a partner’s sexual overtures. In contrast, the inclination to make one’s self sexually attractive to others was a more complicated function of partner status, gender, and age: partnered women and unpartnered men made the most effort, with the more effortful gender’s effort decreasing with age. Both men and women find nonsexual physical contact appealing but sexual physical contact is more appealing to men than women. Finally, two fifths of men and women report dissatisfaction with their partner’s frequency of caring behaviors that make later sexual interactions pleasurable, and a fifth of women and a quarter of men who had vaginal sex in the past year report dissatisfaction with amount of foreplay. Discussion. These data offer the opportunity to characterize sexual motivation in older adulthood more precisely and richly and to examine how the context of sexual experience and the nonsexual aspects of physical intimacy correlate with sexual behavior, enjoyment, and problems. PMID:25360027

  19. Origins and Elaboration of the National Health Accounts, 1926-2006

    PubMed Central

    Fetter, Bruce

    2006-01-01

    The National Health Statistics Group (NHSG) has managed to keep the national health accounts (NHA) apolitical and highly respected. NHSG strategies have included the careful acquisition and presentation of statistics relating to health costs and payers; the use of scholarly journals to disseminate ideas to other government offices and, beyond them, to industry, labor, the professions, and universities; and the promotion of cooperation with related U.S., statistical agencies, provider groups, contractors, and international organizations. Responding to an increasingly complex system of third-party payers in the U.S. health system and controversies over methods, the NHA has continually evolved to meet the demands of health care decisionmakers. Historically, these dialogues have forced health accountants to refine their methods to ensure that their portrayal of spending and financing trends presents information that can inform the decisionmaking process in a non-partisan way. PMID:17290668

  20. National Needs of Family Planning Among US Men Aged 15 to 44 Years

    PubMed Central

    Gibbs, Susannah E.; Choiriyyah, Ifta; Sonenstein, Freya L.; Astone, Nan M.; Pleck, Joseph H.; Dariotis, Jacinda K.

    2016-01-01

    Objectives. To estimate national need for family planning services among men in the United States according to background characteristics, access to care, receipt of services, and contraception use. Methods. We used weighted data from the 2006–2010 National Survey of Family Growth to estimate the percentage of men aged 15 to 44 years (n = 10 395) in need of family planning, based on sexual behavior, fecundity, and not trying to get pregnant with his partner. Results. Overall, 60% of men were in need of family planning, defined as those who ever had vaginal sex, were fecund, and had fecund partner(s) who were not trying to get pregnant with partner or partner(s) were not currently pregnant. The greatest need was among young and unmarried men. Most men in need of family planning had access to care, but few reported receiving family planning services (< 19%), consistently using condoms (26%), or having partners consistently using contraception (41%). Conclusions. The need for engaging men aged 15 to 44 years in family planning education and care is substantial and largely unmet despite national public health priorities to include men in reducing unintended pregnancies. PMID:26890180

  1. National Lung Screening Trial Findings by Age: Medicare-Eligible Versus Under-65 Population

    PubMed Central

    Pinsky, Paul F.; Gierada, David S.; Hocking, William; Patz, Edward F.; Kramer, Barnett S.

    2015-01-01

    Background The NLST (National Lung Screening Trial) showed reduced lung cancer mortality in high-risk participants (smoking history of ≥30 pack-years) aged 55 to 74 years who were randomly assigned to screening with low-dose computed tomography (LDCT) versus those assigned to chest radiography. An advisory panel recently expressed reservations about Medicare coverage of LDCT screening because of concerns about performance in the Medicare-aged population, which accounted for only 25% of the NLST participants. Objective To examine the results of the NLST LDCT group by age (Medicare-eligible vs. <65 years). Design Secondary analysis of a group from a randomized trial (NCT00047385). Setting 33 U.S. screening centers. Patients 19 612 participants aged 55 to 64 years (under-65 cohort) and 7110 participants aged 65 to 74 years (65+ cohort) at randomization. Intervention 3 annual rounds of LDCT screening. Measurements Demographics, smoking and medical history, screening examination adherence and results, diagnostic follow-up procedures and complications, lung cancer diagnoses, treatment, survival, and mortality. Results The aggregate false-positive rate was higher in the 65+ cohort than in the under-65 cohort (27.7% vs. 22.0%; P < 0.001). Invasive diagnostic procedures after false-positive screening results were modestly more frequent in the older cohort (3.3% vs. 2.7%; P = 0.039). Complications from invasive procedures were low in both groups (9.8% in the under-65 cohort vs. 8.5% in the 65+ cohort). Prevalence and positive predictive value (PPV) were higher in the 65+ cohort (PPV, 4.9% vs. 3.0%). Resection rates for screen-detected cancer were similar (75.6% in the under-65 cohort vs. 73.2% in the 65+ cohort). Five-year all-cause survival was lower in the 65+ cohort (55.1% vs. 64.1%; P = 0.018). Limitation The oldest screened patient was aged 76 years. Conclusion NLST participants aged 65 years or older had a higher rate of false-positive screening results than those

  2. Common Alzheimer's Disease Research Ontology: National Institute on Aging and Alzheimer's Association collaborative project.

    PubMed

    Refolo, Lorenzo M; Snyder, Heather; Liggins, Charlene; Ryan, Laurie; Silverberg, Nina; Petanceska, Suzana; Carrillo, Maria C

    2012-07-01

    Alzheimer's disease is recognized as a public health crisis worldwide. As public and private funding agencies around the world enhance and expand their support of Alzheimer's disease research, there is an urgent need to coordinate funding strategies and leverage resources to maximize the impact on public health and avoid duplication of effort and inefficiency. Such coordination requires a comprehensive assessment of the current landscape of Alzheimer's disease research in the United States and internationally. To this end, the National Institute on Aging at the National Institutes of Health and the Alzheimer's Association developed the Common Alzheimer's Disease Research Ontology (CADRO) as a dynamic portfolio analysis tool that can be used by funding agencies worldwide for strategic planning and coordination.

  3. Effect of material aging on parachute pack life: a synopsis of Sandia National Laboratories studies

    SciTech Connect

    Auerbach, I.; Mead, J.W.; Mead, K.E.; Ericksen, R.H.; Burns, F.B.; Renschler, C.L.

    1984-01-01

    A systematic study of the effects of environmental factors on nylon 66 and Kevlar 29 strength degradation in parachute components is being conducted at Sandia National Laboratories. It includes: (1) accelerated aging studies in air, inert environments, humidity, ozone, and smog; (2) a 25-year surveillance program of parachutes in a variety of natural climatic environments; (3) moisture absorption as a function of humidity; (4) effects of surface coatings normally applied to parachutes; and (5) development of nondestructive evaluation techniques which can be used to map mechanical properties over the entire parachute surface. The accelerated aging and moisture absorption studies show that air, humidity, and smog contribute to degradation. Chemiluminescence, gas chromatographic pyrograms, and uv spectroscopy show promise as nondestructive evaluation techniques.

  4. ORIGIN OF THERMAL FLUIDS AT LASSEN VOLCANIC NATIONAL PARK: EVIDENCE FROM NOBLE AND REACTIVE GAS ABUNDANCES.

    USGS Publications Warehouse

    Truesdell, Alfred H.; Mazor, Emanuel; Nehring, Nancy L.

    1983-01-01

    Thermal fluid discharges at Lassen are dominated by high-altitude fumaroles and acid-sulfate hot springs in the Park, and lower altitude, neutral, high-chloride hot springs in Mill Valley 7-10 km to the south. The interrelations of these fluids have been studied by noble and reactive gas analyses. Atmospheric noble gas (ANG) contents of superheated fumaroles are similar to those of air-saturated recharge water (ASW) at 5 degree C and 2500-m elevation. Low-elevation, high-chloride, hot-spring waters are highly depleted in ANG, relative to the ASW. The surface temperatures and gas chemistry of the fumaroles and hot springs suggest that steam originating from partial to near-complete vaporization of liquid from a boiling, high-chloride, hot water aquifer is decompressed adiabatically, and more or less mixed with shallow groundwater to form superheated and drowned fumaroles within the Park. Refs.

  5. Age, origin and evolution of Antarctic debris-covered glaciers: Implications for landscape evolution and long-term climate change

    NASA Astrophysics Data System (ADS)

    Mackay, Sean Leland

    Antarctic debris-covered glaciers are potential archives of long-term climate change. However, the geomorphic response of these systems to climate forcing is not well understood. To address this concern, I conducted a series of field-based and numerical modeling studies in the McMurdo Dry Valleys of Antarctica (MDV), with a focus on Mullins and Friedman glaciers. I used data and results from geophysical surveys, ice-core collection and analysis, geomorphic mapping, micro-meteorological stations, and numerical-process models to (1) determine the precise origin and distribution of englacial and supraglacial debris within these buried-ice systems, (2) quantify the fundamental processes and feedbacks that govern interactions among englacial and supraglacial debris, (3) establish a process-based model to quantify the inventory of cosmogenic nuclides within englacial and supraglacial debris, and (4) isolate the governing relationships between the evolution of englacial /supraglacial debris and regional climate forcing. Results from 93 field excavations, 21 ice cores, and 24 km of ground-penetrating radar data show that Mullins and Friedman glaciers contain vast areas of clean glacier ice interspersed with inclined layers of concentrated debris. The similarity in the pattern of englacial debris bands across both glaciers, along with model results that call for negligible basal entrainment, is best explained by episodic environmental change at valley headwalls. To constrain better the timing of debris-band formation, I developed a modeling framework that tracks the accumulation of cosmogenic 3He in englacial and supraglacial debris. Results imply that ice within Mullins Glacier increases in age non-linearly from 12 ka to ˜220 ka in areas of active flow (up to >> 1.6 Ma in areas of slow-moving-to-stagnant ice) and that englacial debris bands originate with a periodicity of ˜41 ka. Modeling studies suggest that debris bands originate in synchronicity with changes in

  6. Age moderates the association of depressive symptoms and unhealthy alcohol use in the National Guard.

    PubMed

    Sahker, Ethan; Acion, Laura; Arndt, Stephan

    2016-12-01

    Unhealthy drinking is a significant problem contributing to poor health and performance of military personnel. The Iowa Army National Guard and the Iowa Department of Public Health have collaborated with the Substance Abuse and Mental Health Administration to better identify unhealthy substance use via Screening, Brief Intervention, and Referral to Treatment program (SBIRT). Yet, little research has been conducted on the Guard's use of SBIRT. This study examined depression, age, deployment status, and sex as factors contributing to unhealthy drinking. Of the Guardsmen who took part in SBIRT, 3.7% (n=75) met the criteria for unhealthy drinking and 3.9% (n=78) had some level of depression. The overall multivariate model significantly predicted unhealthy drinking (χ(2)(5)=41.41, p<0.001) with age moderating the association of depressive symptoms and unhealthy alcohol (Wald χ(2)(1)=7.16, p=0.007). These findings add to the existing understanding of factors contributing to unhealthy drinking suggesting the association between the presence of depression and unhealthy drinking depends on age of the Guradsman. This age and depression interaction may be an important diagnostic feature to consider for unhealthy drinking in the Guard. Furthermore, previous research on the general military population finds similar percentages, providing support for SBIRT as an effective screening tool in the Guard. PMID:27450908

  7. Age moderates the association of depressive symptoms and unhealthy alcohol use in the National Guard.

    PubMed

    Sahker, Ethan; Acion, Laura; Arndt, Stephan

    2016-12-01

    Unhealthy drinking is a significant problem contributing to poor health and performance of military personnel. The Iowa Army National Guard and the Iowa Department of Public Health have collaborated with the Substance Abuse and Mental Health Administration to better identify unhealthy substance use via Screening, Brief Intervention, and Referral to Treatment program (SBIRT). Yet, little research has been conducted on the Guard's use of SBIRT. This study examined depression, age, deployment status, and sex as factors contributing to unhealthy drinking. Of the Guardsmen who took part in SBIRT, 3.7% (n=75) met the criteria for unhealthy drinking and 3.9% (n=78) had some level of depression. The overall multivariate model significantly predicted unhealthy drinking (χ(2)(5)=41.41, p<0.001) with age moderating the association of depressive symptoms and unhealthy alcohol (Wald χ(2)(1)=7.16, p=0.007). These findings add to the existing understanding of factors contributing to unhealthy drinking suggesting the association between the presence of depression and unhealthy drinking depends on age of the Guradsman. This age and depression interaction may be an important diagnostic feature to consider for unhealthy drinking in the Guard. Furthermore, previous research on the general military population finds similar percentages, providing support for SBIRT as an effective screening tool in the Guard.

  8. Influences of competition level, gender, player nationality, career stage and playing position on relative age effects.

    PubMed

    Schorer, J; Cobley, S; Büsch, D; Bräutigam, H; Baker, J

    2009-10-01

    Relative age, referring to the chronological age differences between individuals within annually age-grouped cohorts, is regarded as influential to an athlete's development, constraining athletic skill acquisition. While many studies have suggested different mechanisms for this effect, they have typically examined varying sports, precluding an examination of the possible inter-play between factors. Our three studies try to bridge this gap by investigating several moderators for relative age effects (RAEs) in one sport. Handball is a sport with position-specific demands, high cultural relevance and a performance context with established developmental structures and levels of representation for males and females. In Study 1, we investigated the influence of competition level and gender on RAEs before adulthood. In Study 2, elite participation, player nationality and stage of career are considered during adulthood. In Study 3, playing position and laterality (i.e., right vs left handedness) are investigated as moderators. Collectively, the results emphasize the complex inter-play of direct and indirect influences on RAEs in sports, providing evidence toward explaining how RAEs influence the development and maintenance of expertise.

  9. Biological aging and social characteristics: gerontology, the Baltimore city hospitals, and the National Institutes of Health.

    PubMed

    Park, Hyung Wook

    2013-01-01

    The intramural gerontological research program in the National Institutes of Health underwent a substantial growth after its creation within the precincts of the Baltimore City Hospitals in 1940. This paper analyzes its development and the associated problems of its early years. Gerontologists aimed at improving the social and economic life of the elderly through scientific research. With this aim in mind, they conducted various investigations using the indigent aged patients of the Baltimore City Hospitals. Yet the scientists of aging, who hoped to eliminate negative social factors that might bias their research and heighten the confusion between pathology and aging per se, eventually stopped using these patients in the hospital as human subjects. Instead they sought educated affluent subjects in order to eliminate the impact of poverty. By doing so, however, they introduced a new source of social bias to their work, especially within the novel project begun in 1958, the Baltimore Longitudinal Study of Aging. This article thus examines the context of the development of gerontologists' research by analyzing their agenda, institutional environment, and research subjects in the 1940s and the 1950s.

  10. Depression, socioeconomic status, age, and marital status in black women: a national study.

    PubMed

    Scarinci, Isabel C; Beech, Bettina M; Naumann, Wendy; Kovach, Kristen W; Pugh, Letha; Fapohunda, Bolaji

    2002-01-01

    This study examined the relationship between an array of socioeconomic status (SES) indicators and depression among Black women; determined which SES indicator was most strongly associated with depression; and examined whether the relationship between SES and depression was the same across age and marital status. A sample of 1,407 Black women recruited through the National Black Women's Health Project completed a survey on psychological well-being. Independent variables included income, education, median income within zip codes, marital status, and age. The dependent variable was depression as measured by the CES-D. The average CES-D score among participants was 12.67 (SD = 10.54), and 31.9% screened positive for depression. An inverse relationship was found between income and education and depression. The higher the yearly household income and education level the lower the scores on the CES-D. Income was the SES indicator most strongly associated with depression. Younger women had higher scores on the CES-D. Never-married women exhibited significantly higher levels of depression compared to women who were married or living together with an intimate partner. There were no significant interactions between SES indicators, age, and marital status. These findings suggest that income, education level, marital status, and age may be important demographic variables to consider when designing interventions to address depression among Black women.

  11. Origin, age, and paleoclimatic setting of the Late Quaternary deposits in Wadi Feiran, Sinai Peninsula: Geomorphologic, geochronologic, and isotopic constraints

    NASA Astrophysics Data System (ADS)

    Farag, A. Z. A.; Sultan, M.; Forman, S. L.; Krishnamurthy, R. V.

    2015-12-01

    There is considerable debate on the origin, age, and paleoclimatic setting of Late Quaternary deposits within the basement complex of the Sinai Peninsula. Our research in Wadi Feiran focused on documenting the sedimentology, stratigraphy, geochemistry and chronology of Late Quaternary deposits in the Feiran (lat. 28.706 N; long. 33.665; elevation: 715 to 772 m a.m.s.l) and Tarfa (lat. 28.692 N; long. 33.933 E; elevation: 1160 to 1244 m a.m.s.l) oases. Sequence stratigraphy, analysis of remote sensed images, and groundwater levels in these two areas indicate that the investigated deposits are structurally-controlled as they are found in areas with anomalously elevated groundwater levels and upstream from shear zone/wadi intersections. Sediments are largely arenaceous upstream and transition downstream to marly successions. We infer that these sediments were not deposited in lake settings because of the absence of shorelines and associated littoral, sublittoral and deeper water facies, and the presence of rhizoliths, secondary calcite veins and gastropods, all of which suggest deposition in a spring or wetland environment. A short hydrologic residence time and/or deposition in an open water system is supported by the lack of correlation (R = 0.08) between δ18O and δ13C values in carbonate deposits. Our findings are consistent with deposition of sediments by alluvial, fluvial and paludal processes under variable hydrologic conditions and higher water table conditions. Quartz extracts from these sediments yielded optically stimulated luminescence ages between ca. 27 and 11 ka and place these wetter conditions during the last glacial period and extend the "greening" of North Africa further eastward. Our findings are consistent with models which identify the wet periods in the Late Quaternary in the Sinai Peninsula and in North Africa as being glacial periods.

  12. The origin and evolution of the optics specifications for the National Ignition Facility

    SciTech Connect

    Aikens, D.

    1995-06-27

    In the second half of the 1990`s, LLNL and others will be designing and beginning construction of the National Ignition Facility (NIF). At more than 10 times the power and size of the Nova laser system, this new laser will be capable of producing the worlds first controlled fusion ignition and burn, completing a vital milestone on the path to Fusion Energy. In order to optimize the performance of the laser system for a minimum cost, the designers have been conducting a campaign to properly specify the optical properties of the more than 7,500 large optical components to be deployed in the NIF. The draft optics specifications derived from this effort will be presented. The evolution of these specifications, both in language and in content, will be discussed, specifically transmitted wavefront (both P-V and PSD), scratch/dig, surface roughness, bubbles and inclusions specifications.

  13. Origins and development of the National Laboratory System for public health testing.

    PubMed

    Astles, J Rex; White, Vanessa A; Williams, Laurina O

    2010-01-01

    Although not recognized as such, a National Laboratory System (NLS) has existed since the inception of public health laboratory (PHL) testing more than a century ago. The NLS has always relied upon the participation of clinical laboratories, both to report test results that represent public health threats and to submit specimens and isolates to PHLs for additional or confirmatory testing. Historically, a number of factors have hindered the strengthening of the relationships between clinical laboratories and PHLs, but the reality of bioterrorism and subsequent focus on strengthening public-private relationships has stimulated the development of a more robust NLS. Since 2002, there has been substantial strengthening of the NLS through the sharing of lessons learned from several demonstration projects. There is a growing emphasis on defining critical elements of the NLS, including the State Public Health Laboratory System (SPH Laboratory System) and the functions of the Laboratory Program Advisor, a position that every state should have at the center of its laboratory system's capacity-building. Additional strengthening of the NLS is occurring through (1) national biennial measurement of state PHLs' abilities to meet the Core Functions and Capabilities of State PHLs, (2) the new Laboratory System Improvement Program (L-SIP) for the SPH Laboratory System, and (3) sharing ideas to integrate and improve the SPH Laboratory System (e.g., using the L-SIP Online Resource Center). Public health emergencies, such as the recent H1N1 epidemic, illustrate and reinforce the need for a strong NLS within which federal, public health, and clinical (i.e., hospital and private reference) laboratories function in close collaboration. PMID:20518442

  14. Early climate change consensus at the National Academy: the origins and making of "Changing Climate".

    PubMed

    Nierenberg, Nicolas; Tschinkel, Walter R; Tschinkel, Victoria J

    2010-01-01

    The 1983 National Academy of Sciences report entitled "Changing Climate," authored by a committee of physical and social scientists chaired by William Nierenberg, was an early comprehensive review of the effects of human-caused increases in the levels of atmospheric CO2. Study of the events surrounding the committee's creation, deliberations, and subsequent report demonstrates that the conclusions of the report were the consensus of the entire committee and in line with the scientific consensus of the time. This result contraverts a 2008 paper in which Naomi Oreskes, Erik M. Conway, and Matthew Shindell asserted that the report contradicted a growing consensus about climate change, and that Nierenberg for political reasons deliberately altered the summary and conclusions of the report in a way that played down the concerns of the other physical scientists on the committee. Examining the production of the report and contextualizing it in contemporaneous scientific and political discussion, we instead show how it was a multi-year effort with work divided among the various members of the committee according to their expertise. The synthesis and conclusions were expressly a joint statement of the committee and were consistent with other assessments of that time expressing deep concern over the potential issues while stopping short of recommending major policy changes due to the uncertainties, and to a lack of good alternatives. PMID:20848755

  15. Tick-borne relapsing fever: an interstate outbreak originating at Grand Canyon National Park.

    PubMed

    Boyer, K M; Munford, R S; Maupin, G O; Pattison, C P; Fox, M D; Barnes, A M; Jones, W L; Maynard, J E

    1977-05-01

    During the 1973 summer season, 27 employees and 35 overnight guests at the North Rim, Grand Canyon National Park, Arizona, acquired febrile illnesses compatibel with relapsing fever. Sixteen cases were confirmed by finding Borrelia spirochetes in peripheral blood smears or inoculated Swiss mice. Retrospective surveys of 278 employees and 7247 guests at the park revealed that acquisition of illness was significantly associated with the persons sleeping in rustic log cabins and acquiring bites of "unknown" insects. From rodent nesting materials found in the walls and attics of cabins where cases had occurred, infective Ornithodoros hermsi ticks were recovered. Exceptional activity of ticks in human populations appeared to have resulted from a decreased population of the ticks' usual rodent hosts. Vector control activities consisted of spraying the cabins with residual insecticide, removing nesting materials, and "rodent proofing." This outbreak, the largest yet identified in North America, extends the known range of a principal vector and establishes the North Rim as an endemic source of tick-borne relapsing fever.

  16. [Prevalence of nutritional anemia in women of reproductive age. Costa Rica. National nutrition survey, 1996].

    PubMed

    Rodríguez, S; Blanco, A; Cunningham, L; Ascencio, M; Chávez, M; Muñoz, L

    2001-03-01

    In 1996, The Ministry of Health and Inciensa conducted the latest National Nutrition Survey, to provide support and guidance to the national policies, plans and programs in the field of food and nutrition. The present paper reports the results for the prevalence of anemia estimated in a total of 884 women of reproductive age, in three areas: metropolitan area, other urban areas and rural areas. Anemia was determined through measurements of hemoglobin, plasma ferritin and plasma folates. In addition, hemoglobin patterns were determined by electrophoresis. The cutt-off points used were those recommended by the WHO. Anemia was present in 18.6% of the women. Severe to moderate deficiency of iron (< 12 ng/dl) and of folates (< 6 ng/dl) were found in 43.2 and 24.7% of women respectively, with statistically significant differences by area of residence. The magnitude of the problem for anemia can be classified as mild, for iron deficiency as severe, and for folate deficiency as moderate. In conclusion, Anemia represents a public health problem for Costa Rica that has remained constant throughout the last decade. In women of reproductive age, iron deficiency is the main cause of Anemia, followed by folates deficiency, and in a small percentage hemoglobinopathies. Intestinal parasites are not longer a mayor cause of Anemia. Prevalence of Anemia is influenced by place of residence, but not by age. In summary, despite the favorable health conditions present in Costa Rica, the prevalence of Anemia and of iron deficiency are similar to those of the Latin-American region. To improve this situation, public health interventions are necessary.

  17. Sodium intake among U.S. school-age children: National Health and Nutrition Examination Survey, 2011-2012

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Identifying current major dietary sources of sodium can enhance strategies to reduce excess sodium intake which occurs among 90% of U.S. school-aged children. We conducted a cross-sectional analysis of 24-hour dietary recall data from a nationally representative sample of 2,142 U.S. children aged 6...

  18. School Entry Age and Children's Social-Behavioral Skills: Evidence From a National Longitudinal Study of U.S. Kindergartners

    ERIC Educational Resources Information Center

    Datar, Ashlesha; Gottfried, Michael A.

    2015-01-01

    Prior research evaluating school entry age effects has largely overlooked the effects on social-behavioral skills despite the growing recognition of returns to such skills. This study is the first to examine the effects of kindergarten entry age on children's social-behavioral outcomes using 9 years of panel data on a national sample of U.S.…

  19. Towards the Theory of the Age, Origin and Demise of the Universe - A Geochemical/Isotopic Perspective

    NASA Astrophysics Data System (ADS)

    Gargi, S. P.

    2005-12-01

    Both the Big Bang and Unified Field theories are derived from Einstein's well known theory of Relativity. The former only describes how the Universe was created, that is by the explosion of an extremely condensed state of energy, the Singular State. It provides no information regarding the time of its creation. The latter shows that progressively heavier matter is continually created in space-time from structured nothingness. However, Hubble later showed a strong correlation between the relative distantance of the galaxies and their receding velocity. As the array formed by this relation passes through the point of origin, it was readily accepted as the physical evidence for the Big Bang theory. Based on this relation at that time, the age of the Universe was estimated to be less than 4 Gyrs. The upper age limit of formation (TM ) of any radioactive isotope by nucleosynthesis can be determined, provided no daughter isotopes were formed at that time, from the equation: N = NA × e(-λTM); where NA is the total number of parent nuclides formed, N is the number of present-day parent nuclides, and λ is the decay constant. The above equation yields the TM age of 155, 196, 17.68, 5.56, and 7.16 Gyrs for 87Rb, 147Sm, 232Th, 235U, 238U respectively. For these elements to form at any time later than their respective TM, part of their daughter isotopes also have to be formed by nucleosynthesis. For example, if 232Th were to form about seven Gyrs ago, it would require that 85% of 208Pb/204Pb be formed by nucleosynthesis. Thus the three isotopes 232Th, 235U, and 238U, no matter when they form between 17.68 and 4.55 Gyrs ago; they all violate the Unified Field theory, either because of the formation of 208Pb before 206Pb and 207Pb, or the formation of 238U before 235U. The time of total decay (TD) for any radioactive isotope cannot be determined by using the radioactivity equation. One possible way is to estimate the TD age by extrapolating the bulk Earth parent atomic

  20. Differences in the prevalence of hypertension by ethnic origin and age at immigration in a cohort of 5,146 Israelis.

    PubMed

    Green, M S; Peled, I

    1992-06-01

    Marked ethnic differences in hypertension prevalence have been described in Jewish immigrants to Israel. The extent to which this phenomenon has persisted after a long period of living in the same country, and whether native-born descendants exhibit similar patterns, is not clear. The aim of this study was to determine the prevalence of hypertension in immigrants to Israel and native-born Israelis by region of origin and age at immigration. Complete data were available for 5,146 subjects (3,607 men and 1,539 women) aged 20-64 years who were employed in Israeli industries and were examined during 1985-1987. In both sexes, Jews originating in the West (Europe and the Americas) had higher blood pressures and a significantly higher prevalence of hypertension than those from northern Africa or Asia, particularly in the age group 20-44 years (17% vs. 9% and 8% in men, respectively, and 9% vs. 3% and 5% in women). There was a significant positive association between the prevalence of hypertension and age at immigration (p less than 0.001) in both sexes, and this finding was present in all ethnic groups. In multiple logistic regression analysis, the associations of hypertension with ethnic origin and age at immigration were only partly explained by variations in body mass index, after controlling for other potentially confounding variables. These findings suggest that despite these subjects' having shared a relatively similar physical environment for many years, ethnic differences in the prevalence of hypertension persist. Immigration at an older age was associated with a higher prevalence of hypertension for both subjects originating in industrialized countries and those originating in nonindustrialized countries, suggesting that the process of immigration itself may adversely affect blood pressure. PMID:1378241

  1. The National Anesthesia Clinical Outcomes Registry: A Sustainable Model for the Information Age?

    PubMed Central

    Dutton, Richard P.

    2014-01-01

    Anesthesiologists care for patients of all ages, with all conceivable comorbidities, in every kind of health care facility. This leads to a significant challenge in the collection of data to describe the specialty, and in the development of evidence-based performance measures for anesthesiologists. Whereas narrowly defined medical specialties have developed registries based on manual abstraction of clinical data from the medical record (e.g., cardiac surgery), this approach would be prohibitively expensive for anesthesiology, and is unlikely to generate statistically useful data when major adverse outcomes occur a handful of times in tens of thousands of cases. The American Society of Anesthesiologists (ASA) addressed this challenge in 2008 by funding a related organization, the Anesthesia Quality Institute (AQI), to develop the National Anesthesia Clinical Outcomes Registry (NACOR). The technical development of this registry and the approach taken to define the specialty of anesthesiology and the performance of anesthesiologists may serve as a model for other specialty society efforts. PMID:25848607

  2. Early child care and obesity at 12 months of age in the Danish National Birth Cohort

    PubMed Central

    Neelon, Sara E Benjamin; Andersen, Camilla Schou; Morgen, Camilla Schmidt; Kamper-Jørgensen, Mads; Oken, Emily; Gillman, Matthew W; Sørensen, Thorkild IA

    2014-01-01

    Background/Objectives Evidence suggests that the child care environment may be more obesogenic than the family home, and previous studies have found that child care use may be associated with obesity in children. Few studies, however, have focused on child care during infancy, which may be an especially vulnerable period. This study examined child care use in infancy and weight status at 12 months of age in a country where paid maternity leave is common and early child care is not as prevalent as in other developed countries. Subjects/Methods We studied 27821 children born to mothers participating in the Danish National Birth Cohort (DNBC), a longitudinal study of pregnant women enrolled between 1997 and 2002, who were also included in the Childcare Database, a national record of child care use in Denmark. The exposure was days in child care from birth to 12 months. The outcomes were sex-specific body mass index (BMI) z-score and overweight/obesity (BMI ≥85th percentile based on the World Health Organization classification) at 12 months. We conducted multivariable linear and logistic regression analyses examining child care use and weight outcomes. Results A total of 17721 (63.7%) children attended child care during their first year of life. After adjustment for potential confounders, a 30-day increment of child care was associated with a modestly higher BMI z-score at 12 months (0.03 units; 95% CI: 0.01, 0.05; p=0.003). Similarly, child care use was associated with increased odds of being overweight/obese at 12 months of age (OR 1.05; 95% CI: 1.01, 1.10; p=0.047). Conclusions Child care in the first year of life was associated with slightly higher weight at 12 months, suggesting that child care settings may be important targets for obesity prevention in infancy. PMID:25233894

  3. Revisiting the framework of the National Institute on Aging-Alzheimer's Association diagnostic criteria.

    PubMed

    Carrillo, Maria C; Dean, Robert A; Nicolas, François; Miller, David S; Berman, Robert; Khachaturian, Zaven; Bain, Lisa J; Schindler, Rachel; Knopman, David

    2013-09-01

    In 2011, the National Institute on Aging and the Alzheimer's Association (NIA-AA) proposed revising the criteria for diagnosing Alzheimer's disease (AD), which had been established more than 25 years earlier by the National Institute on Neurologic and Communicative Disorders and Stroke (NINCDS) and the Alzheimer's Disease and Related Disorders Association (ADRDA), now called the Alzheimer's Association. The NIA-AA initiative also built upon research criteria for AD proposed by the International Working Group (IWG) in 2007 and updated in 2010. These efforts to revise the criteria reflect the need to improve diagnostic accuracy, facilitate clinical trials, and establish a common set of criteria that are universally accepted across domains of clinical practice, research, and drug development. To ensure that the proposed NIA-AA criteria remain as current as possible, the Alzheimer's Association Research Roundtable convened a meeting in Washington, DC, on October 1 and 2, 2012, bringing together international stakeholders from industry, academia, and regulatory agencies to identify areas of agreement and research gaps respective of NIA-AA criteria and IWG recommendations.

  4. Trajectories of Delinquency from Age 14 to 23 in the National Longitudinal Survey of Youth Sample

    PubMed Central

    Murphy, Debra A.; Brecht, Mary-Lynn; Huang, David; Herbeck, Diane M.

    2012-01-01

    This study utilized data from the National Longitudinal Survey of Youth to investigate risk trajectories for delinquency and factors associated with different trajectories, particularly substance use. The sample (N = 8,984) was 49% female. A group-based trajectory model was applied, which identified four distinct trajectories for both males and females: (1) a High group with delinquency rates consistently higher than other groups, with some decrease across the age range; (2) a Decreased group, beginning at high levels with substantial decrease to near zero; (3) a Moderate group experiencing some decline but remaining at moderate rates of delinquency through most of the age range; and (4) a consistently Low group, having low rates of delinquency declining to near zero by mid- to late-teens. The Low group was distinguished by several protective factors, including higher rates of maternal authoritative parenting style, possible lower acculturation (higher rates of non-English spoken at home), higher rates of religious activity, later substance use initiation, lower rates of early delinquent activity, less early experience with neighborhood or personal violence, and higher rates of perceiving penalty for wrongdoing. Conversely, the High group was characterized by several vulnerability factors—essentially the converse of the protective factors above. PMID:23105164

  5. Age-specific survival of reintroduced swift fox in Badlands National Park and surrounding lands

    USGS Publications Warehouse

    Sasmal, Indrani; Klaver, Robert W.; Jenks, Jonathan A.; Schroeder, Greg M.

    2016-01-01

    In 2003, a reintroduction program was initiated at Badlands National Park (BNP), South Dakota, USA, with swift foxes (Vulpes velox) translocated from Colorado and Wyoming, USA, as part of a restoration effort to recover declining swift fox populations throughout its historical range. Estimates of age-specific survival are necessary to evaluate the potential for population growth of reintroduced populations. We used 7 years (2003–2009) of capture–recapture data of 243 pups, 29 yearlings, and 69 adult swift foxes at BNP and the surrounding area to construct Cormack–Jolly–Seber model estimates of apparent survival within a capture–mark–recapture framework using Program MARK. The best model for estimating recapture probabilities included no differences among age classes, greater recapture probabilities during early years of the monitoring effort than later years, and variation among spring, winter, and summer. Our top ranked survival model indicated pup survival differed from that of yearlings and adults and varied by month and year. The apparent annual survival probability of pups (0.47, SE = 0.10) in our study area was greater than the apparent annual survival probability of yearlings and adults (0.27, SE = 0.08). Our results indicate low survival probabilities for a reintroduced population of swift foxes in the BNP and surrounding areas. Management of reintroduced populations and future reintroductions of swift foxes should consider the effects of relative low annual survival on population demography.

  6. Pathological video-game use among youth ages 8 to 18: a national study.

    PubMed

    Gentile, Douglas

    2009-05-01

    Researchers have studied whether some youth are "addicted" to video games, but previous studies have been based on regional convenience samples. Using a national sample, this study gathered information about video-gaming habits and parental involvement in gaming, to determine the percentage of youth who meet clinical-style criteria for pathological gaming. A Harris poll surveyed a randomly selected sample of 1,178 American youth ages 8 to 18. About 8% of video-game players in this sample exhibited pathological patterns of play. Several indicators documented convergent and divergent validity of the results: Pathological gamers spent twice as much time playing as nonpathological gamers and received poorer grades in school; pathological gaming also showed comorbidity with attention problems. Pathological status significantly predicted poorer school performance even after controlling for sex, age, and weekly amount of video-game play. These results confirm that pathological gaming can be measured reliably, that the construct demonstrates validity, and that it is not simply isomorphic with a high amount of play.

  7. Old-age pensions and population health: a global and cross-national perspective.

    PubMed

    Sjöberg, Ola

    2014-01-01

    Social security schemes can reduce poverty risk and increase resources available for individuals and families, and these schemes may therefore have an important role to play in population health in both high- and middle-income countries. This article analyses the linkage between effective coverage of old-age pension schemes and life expectancy in a sample of 93 high- and middle-income countries at the end of the twenty-first century. The analyses support the notion that social security schemes, and especially programmes with a universal approach, may have positive effects on population health, even after taking into account the effect of levels of economic development, income inequality and essential characteristics of health care systems. This article also demonstrates that there is no evident relationship between levels of economic development and social security legislation: historically, late industrialisers were often first in introducing major social security schemes, and today there is no clear cross-national relationship between levels of economic development and the proportion of the population covered by old-age pension schemes. PMID:24524644

  8. National Health Expenditure Growth in the 1980's: An Aging Population, New Technologies, and Increasing Competition

    PubMed Central

    Freeland, Mark S.; Schendler, Carol Ellen

    1983-01-01

    Health care spending in the United States more than tripled between 1971 and 1981, increasing from $83 billion to $287 billion. This growth in health sector spending substantially outpaced overall growth in the economy, averaging 13.2 percent per year compared to 10.5 percent for the gross national product (GNP). By 1981, one out of every ten dollars of GNP was spent on health care, compared to one out of every thirteen dollars of GNP in 1971. If current trends continue and if present health care financing arrangements remain basically unchanged, national health expenditures are projected to reach approximately $756 billion in 1990 and consume roughly 12 percent of GNP. The focal issue in health care today is cost and cost Increases. The outlook for the 1980's is for continued rapid growth but at a diminished rate. The primary force behind this moderating growth is projected lower inflation. However, real growth rates are also expected to moderate slightly. The chief factors influencing the growth of health expenditures in the eighties are expected to be aging of the population, new medical technologies, increasing competition, restrained public funding, growth in real income, increased health manpower, and a deceleration in economy-wide inflation. Managers, policy makers and providers in the health sector, as in all sectors, must include in today's decisions probable future trends. Inflation, economic shocks, and unanticipated outcomes of policies over the last decade have intensified the need for periodic assessments of individual industries and their relationship to the macro economy. This article provides such an assessment for the health care industry. Baseline current-law projections of national health expenditures are made to 1990. PMID:10309852

  9. National and state vaccination coverage among adolescents aged 13-17 years--United States, 2012.

    PubMed

    2013-08-30

    At ages 11 through 12 years, the Advisory Committee on Immunization Practices (ACIP) recommends that preteens receive 1 dose of tetanus, diphtheria, and acellular pertussis (Tdap) vaccine, 1 dose of meningococcal conjugate (MenACWY) vaccine, and 3 doses of human papillomavirus (HPV) vaccine. ACIP recommends administration of all age-appropriate vaccines during a single visit. ACIP also recommends that pre-teens and older adolescents receive an annual influenza vaccine as well as any overdue vaccines (e.g., varicella). To monitor vaccination coverage among persons aged 13-17 years, CDC analyzed data from the National Immunization Survey-Teen (NIS-Teen). This report highlights findings of that analysis. From 2011 to 2012, coverage increased for ≥1 Tdap vaccine dose (from 78.2% to 84.6%), ≥1 MenACWY vaccine dose (from 70.5% to 74.0%) and, among males, ≥1 HPV vaccine dose (from 8.3% to 20.8%). Among females, vaccination coverage estimates for each HPV vaccine series dose were similar in 2012 compared with 2011. Coverage varied substantially among states. Regarding Healthy People 2020 targets for adolescents, 36 states achieved targets for Tdap, 12 for MenACWY, and nine for varicella vaccine coverage. Large and increasing coverage differences between Tdap and other vaccines recommended for adolescents indicate that substantial missed opportunities remain for vaccinating teens, especially against HPV infection. Health-care providers should administer recommended HPV and meningococcal vaccinations to boys and girls during the same visits when Tdap vaccine is given. In addition, whether for health problems or well-checks, providers, parents, and adolescents should use every health-care visit as an opportunity to review adolescents' immunization histories and ensure that every adolescent is fully vaccinated.

  10. National and state vaccination coverage among adolescents aged 13-17 years--United States, 2012.

    PubMed

    2013-08-30

    At ages 11 through 12 years, the Advisory Committee on Immunization Practices (ACIP) recommends that preteens receive 1 dose of tetanus, diphtheria, and acellular pertussis (Tdap) vaccine, 1 dose of meningococcal conjugate (MenACWY) vaccine, and 3 doses of human papillomavirus (HPV) vaccine. ACIP recommends administration of all age-appropriate vaccines during a single visit. ACIP also recommends that pre-teens and older adolescents receive an annual influenza vaccine as well as any overdue vaccines (e.g., varicella). To monitor vaccination coverage among persons aged 13-17 years, CDC analyzed data from the National Immunization Survey-Teen (NIS-Teen). This report highlights findings of that analysis. From 2011 to 2012, coverage increased for ≥1 Tdap vaccine dose (from 78.2% to 84.6%), ≥1 MenACWY vaccine dose (from 70.5% to 74.0%) and, among males, ≥1 HPV vaccine dose (from 8.3% to 20.8%). Among females, vaccination coverage estimates for each HPV vaccine series dose were similar in 2012 compared with 2011. Coverage varied substantially among states. Regarding Healthy People 2020 targets for adolescents, 36 states achieved targets for Tdap, 12 for MenACWY, and nine for varicella vaccine coverage. Large and increasing coverage differences between Tdap and other vaccines recommended for adolescents indicate that substantial missed opportunities remain for vaccinating teens, especially against HPV infection. Health-care providers should administer recommended HPV and meningococcal vaccinations to boys and girls during the same visits when Tdap vaccine is given. In addition, whether for health problems or well-checks, providers, parents, and adolescents should use every health-care visit as an opportunity to review adolescents' immunization histories and ensure that every adolescent is fully vaccinated. PMID:23985496

  11. Retirement before Age 65. Trends, Costs, and National Issues. Report to the Chairman, Select Committee on Aging, House of Representatives.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC.

    Two issues were analyzed--the changing characteristics of early pension recipients and the costs of early retirement. The analyses covered men and women aged 50 and older and were based primarily on data from the Census Bureau's March 1984 Current Population Survey. Findings showed that the percentage of the population receiving employer-sponsored…

  12. Status homogamy in the preindustrial marriage market: partner selection according to age, social origin, and place of birth in nineteenth-century rural Sweden.

    PubMed

    Dribe, Martin; Lundh, Christer

    2009-10-01

    This article studies partner selection according to three dimensions: social origin, age, and place of birth. The authors use micro-level data from local population registers in five parishes in southern Sweden from 1815 to 1895. The results confirm that all three aspects were important but that socioeconomic status was the most important characteristic, structuring much of the selection process. The importance of social and age homogamy remained stable over the period, while geographic exogamy became more frequent, which could be interpreted in terms of an increasing openness of rural society. The authors also find some indications of exchange of characteristics in the partner selection process.

  13. Mineralogy and Ar-Ar Age of the Tarahumara IIE Iron, with Reference to the Origin of Alkali-Rich Materials

    NASA Technical Reports Server (NTRS)

    Takeda, Hiroshi; Bogard, Donald D.; Otsuki, Mayumi; Ishii, Teruaki

    2003-01-01

    Silicate inclusions in nine known IIE irons show diversity in mineralogy, and Colomera, Kodaikanal, Elga and Miles contain alkali-rich silicate inclusions. Bogard et al. showed evidence of a complex parent body evolution for IIE irons based on Ar-39-Ar-40 ages. Colomera contained a sanidine-rich surface inclusion and the K-enrichment trends in the Na-rich inclusions are different from those of other IIEs. To elucidate the origin of K-rich materials, we studied the mineralogy and Ar-Ar age of silicate inclusions from the Tarahumara IIE iron meteorite.

  14. Age and origin of anorthosites, charnockites, and granulites in the Central Virginia Blue Ridge: Nd and Sr isotopic evidence

    USGS Publications Warehouse

    Pettingill, H.S.; Sinha, A.K.; Tatsumoto, M.

    1984-01-01

    Rb-Sr isotopic data for anorthosites, charnockites, ferrodioritic to quartz monzonitic plutons, and high-grade gneisses of the Blue Ridge of central Virginia show evidence of post-emplacement metamorphism, but in some cases retain Grenville ages. The Pedlar River Charnockite Suite yields an isochron age of 1021 +/-36 Ma, (initial 87Sr/86Sr ratio of 0.7047 +/-6), which agrees with published U-Pb zircon ages. Five samples of that unit which contain Paleozoic mylonitic fabrics define a regression line of 683 Ma, interpreted as a mixing line with no age significance. Samples of the Roseland Anorthosite Complex show excessive scatter on a Rb-Sr evolution diagram probably due to Paleozoic (475 m.y.) metamorphism. Data from the ferrodioritic to quartz monzonitic plutons of the area yield an age of 1009 +/-26 Ma (inital ratio=0.7058 +/-4), which is in the range of the U-Pb zircon ages of 1000-1100 Ma. The Stage Road Layered Gneiss yields an age of 1147 +/-34 Ma (initial ratio of 0.7047 +/- 5). Sm-Nd data for the Pedlar River Charnockite Suite reflect a pre-Grenville age of 1489 +/-118 Ma (e{open}Nd=+6.7 +/-1.2). Data for the Roseland Anorthosite Complex and the ferrodioritic to quartz monzonitic plutons yield Grenville isochron ages of 1045 +/44 Ma (e{open}Nd=+1.0 +/-0.3) and 1027 +/-101 Ma (e{open}Nd=+1.4 +/-1.0), respectively. Two Roseland Anorthosite samples plot far above the isochron, demonstrating the effects of post-emplacement disturbance of Sm-Nd systematics, while mylonitized Pedlar River Charnockite Suite samples show no evidence of Sm-Nd redistribution. The disparity of the Sm-Nd age and other isotopic ages for the Pedlar River Charnockite Suite probably reflects a Sm-Nd "source" age, suggesting the presence of an older crust within this portion of the ca. 1 Ga old basement. ?? 1984 Springer-Verlag.

  15. [Anemia in women of reproductive age. The results of a national probability survey].

    PubMed

    Martínez, H; González-Cossío, T; Flores, M; Rivera-Dommarco, J; Lezana, M A; Sepúlveda-Amor, J

    1995-01-01

    Iron deficiency is one of the most prevalent forms of malnutrition which is clinically known as anemia. Functional consequences of anemia include impairment of cardiovascular performance, limitation in productivity, higher incidence of low birth weight and premature delivery, and increased maternal mortality. This paper presents a descriptive analysis of anemia in women of reproductive age in Mexico. Data were collected by the Ministry of Health through a National Nutrition Survey in 1988, which draw a representative sample from four regions: North, Center, South and Federal District. Anemia was more prevalent in pregnant (18.17%) than in non-pregnant women (15.38%). Those women living in predominantly indigenous communities had higher prevalence of anemia (24.02%) than non-indigenous women (14.67%). Anemia was more prevalent in urban areas (15.54%) than in rural (13.56%). Mean +/- standard deviation values for hemoglobin were lower in pregnant women (12.5 +/- 1.6 g/dL) than in non-pregnant ones (13.7 +/- 1.6 g/dL). Consistently, the Northern and Southern regions were worse off than the Center and the Federal District. These data indicate that anemia is a public health problem in Mexico. The functional consequences of this deficiency justify interventions to treat and prevent it.

  16. [Anemia in women of reproductive age. The results of a national probability survey].

    PubMed

    Martínez, H; González-Cossío, T; Flores, M; Rivera-Dommarco, J; Lezana, M A; Sepúlveda-Amor, J

    1995-01-01

    Iron deficiency is one of the most prevalent forms of malnutrition which is clinically known as anemia. Functional consequences of anemia include impairment of cardiovascular performance, limitation in productivity, higher incidence of low birth weight and premature delivery, and increased maternal mortality. This paper presents a descriptive analysis of anemia in women of reproductive age in Mexico. Data were collected by the Ministry of Health through a National Nutrition Survey in 1988, which draw a representative sample from four regions: North, Center, South and Federal District. Anemia was more prevalent in pregnant (18.17%) than in non-pregnant women (15.38%). Those women living in predominantly indigenous communities had higher prevalence of anemia (24.02%) than non-indigenous women (14.67%). Anemia was more prevalent in urban areas (15.54%) than in rural (13.56%). Mean +/- standard deviation values for hemoglobin were lower in pregnant women (12.5 +/- 1.6 g/dL) than in non-pregnant ones (13.7 +/- 1.6 g/dL). Consistently, the Northern and Southern regions were worse off than the Center and the Federal District. These data indicate that anemia is a public health problem in Mexico. The functional consequences of this deficiency justify interventions to treat and prevent it. PMID:7618111

  17. A reversal of age-dependent proliferative capacity of endothelial progenitor cells from different species origin in in vitro condition

    PubMed Central

    Hassanpour, Mehdi; Cheraghi, Omid; Siavashi, Vahid; Rahbarghazi, Reza; Nouri, Mohammad

    2016-01-01

    Introduction: A large number of cardiovascular disorders and abnormalities, notably accelerated vascular deficiencies could be related to aging changes and increased length of life. During the past decades, the discovery of different stem cells facilitates ongoing attempts for attenuating many disorders, especially in vascular beds. Endothelial progenitor cells (EPCs) are a subtype of stem cells that have potent capacity to differentiate into mature endothelial cells (ECs). However, some documented studies reported an age-related decline in proliferation and function of many stem cells. There is no data on aging effect upon proliferation and morphological feature of EPCs. Methods: To show aging effect on EPCs proliferation and multipotentiality, bone marrow samples were provided from old and young cases in three different species; human, mouse and dog. After 7 days of culture, the cell morphology and clonogenic capacity were evaluated. We also calculated the mean number of colonies both in bone marrow samples from old and young subjects. To confirm the cell phenotype, isolated cells were immune-phenotyped by a panel of antibodies against Tie-2, CD133 and CD309 markers. Results: Our results showed that EPCs exhibited prominent spindle form in all bone marrow samples from young cases while the cell shape became more round by aging. Notably, the number of colonies was reduced in aged samples as compared to parallel young subject samples (P < 0.05). We also detected that the expression of endothelial related markers diminished by aging. Conclusion: The results of this study suggest that the age-related vascular abnormalities could be presumably related to the decline in stemness capacity of EPCs. PMID:27777694

  18. Distinct age and self-rated health crossover mortality effects for African Americans: Evidence from a national cohort study.

    PubMed

    Roth, David L; Skarupski, Kimberly A; Crews, Deidra C; Howard, Virginia J; Locher, Julie L

    2016-05-01

    The predictive effects of age and self-rated health (SRH) on all-cause mortality are known to differ across race and ethnic groups. African American adults have higher mortality rates than Whites at younger ages, but this mortality disparity diminishes with advancing age and may "crossover" at about 75-80 years of age, when African Americans may show lower mortality rates. This pattern of findings reflects a lower overall association between age and mortality for African Americans than for Whites, and health-related mechanisms are typically cited as the reason for this age-based crossover mortality effect. However, a lower association between poor SRH and mortality has also been found for African Americans than for Whites, and it is not known if the reduced age and SRH associations with mortality for African Americans reflect independent or overlapping mechanisms. This study examined these two mortality predictors simultaneously in a large epidemiological study of 12,181 African Americans and 17,436 Whites. Participants were 45 or more years of age when they enrolled in the national REasons for Geographic and Racial Differences in Stroke (REGARDS) study between 2003 and 2007. Consistent with previous studies, African Americans had poorer SRH than Whites even after adjusting for demographic and health history covariates. Survival analysis models indicated statistically significant and independent race*age, race*SRH, and age*SRH interaction effects on all-cause mortality over an average 9-year follow-up period. Advanced age and poorer SRH were both weaker mortality risk factors for African Americans than for Whites. These two effects were distinct and presumably tapped different causal mechanisms. This calls into question the health-related explanation for the age-based mortality crossover effect and suggests that other mechanisms, including behavioral, social, and cultural factors, should be considered in efforts to better understand the age-based mortality

  19. Volunteering and Giving among American Teenagers 14 to 17 Years of Age. Findings from a National Survey. 1990 Edition.

    ERIC Educational Resources Information Center

    Hodgkinson, Virginia A.; Weitzman, Murray S.

    This survey was conducted by the Gallup organization on the volunteering and giving behavior of U.S. teenagers as a supplement to a national survey on giving and volunteering among U.S. adults. Information was obtained from in-home personal interviews with 301 teenagers from 14 to 17 years of age. Results indicated that 58 percent of teenagers…

  20. Realising the Learning Age. A Response to the Government Green Paper from the National Institute of Adult Continuing Education.

    ERIC Educational Resources Information Center

    National Inst. of Adult Continuing Education, Leicester (England).

    Great Britain's National Institute of Adult Continuing Education (NIACE) generally accepts the vision and analysis in the British government green paper "The Learning Age." The NIACE accepts the paper's analysis of the challenges facing Great Britain if it is to become a learning society, and it welcomes the government's commitment to expand…

  1. Development of Ethnic, Racial, and National Prejudice in Childhood and Adolescence: A Multinational Meta-Analysis of Age Differences

    ERIC Educational Resources Information Center

    Raabe, Tobias; Beelmann, Andreas

    2011-01-01

    This meta-analysis summarizes 113 research reports worldwide (121 cross-sectional and 7 longitudinal studies) on age differences in ethnic, racial, or national prejudice among children and adolescents. Overall, results indicated a peak in prejudice in middle childhood (5-7 years) followed by a slight decrease until late childhood (8-10 years). In…

  2. Trajectories of HIV Risk Behavior from Age 15 to 25 in the National Longitudinal Survey of Youth Sample

    ERIC Educational Resources Information Center

    Murphy, Debra A.; Brecht, Mary-Lynn; Herbeck, Diane M.; Huang, David

    2009-01-01

    This study utilized data from the National Longitudinal Survey of Youth to investigate youth risk trajectories for HIV and factors associated with different trajectories. The sample (N = 8,208) was 49.2% female, with a mean age of 14.31 (SD = 1.48). A group-based trajectory model was applied, which identified four distinct trajectories for both…

  3. 76 FR 48873 - National Institute on Aging Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-09

    ... Call). Contact Person: Alicja L. Markowska, PhD, DSC, Scientific Review Branch, National Institute On... Conference Call). Contact Person: Alicja L. Markowska, PHD, DSC, Scientific Review Branch, National...

  4. Hearing levels in US adults aged 20-69 Years: National Health and Nutrition Examination Survey 1999-2002

    NASA Astrophysics Data System (ADS)

    Murphy, William J.; Themann, Christa L.; Franks, John R.

    2005-04-01

    The National Health and Nutrition Examination Survey (NHANES) is a nationally representative, population-based survey designed to assess the health and nutritional status of the civilian, non-institutionalized US population. Data were collected through a personal interview regarding health history and through physical examination. Earlier NHANES surveys were conducted on a periodic basis; however, in 1999, NHANES began collecting data on a continuing, annual basis. During NHANES I, which ran from 1971-1975, audiometric testing was conducted on adults aged 25-74 years. No subsequent testing of adults was conducted in the NHANES program until 1999, when NHANES began audiometric testing of adults aged 20-69 years. This report examines the hearing levels for adults in the United States and compares them with the hearing data from NHANES I. Hearing levels are grouped by age and are grouped by ethnicity and gender.

  5. Comparison of information on death certificates and matching 1960 census records: age, marital status, race, nativity and country of origin.

    PubMed

    Hambright, T Z

    1969-11-01

    A sample of death certificates matched with 1960 Census records permitted comparison of response data for items asked on both records. Estimates of bias in death rates which are based on information from the two records are derived from the comparison data. Most of the comparisons yielded small discrepancies of inconsequential effect on the mortality rates. Some large inconsistencies, however, of potentially serious impact on the death rates were observed. The comparisons are examined and the implications of the results for the relevant mortality rates are discussed. In addition, age-specific death rates "corrected" for the disparities found in the age information on the two records are presented.

  6. 14C age of the "Museum Breccia" (Campi Flegrei) and its relevance for the origin of the Campanian Ignimbrite

    USGS Publications Warehouse

    Lirer, L.; Rolandi, G.; Rubin, M.

    1991-01-01

    Field stratigraphic investigations and AMS 14C dating of carbon particles in paleosols has resulted in a framework of the sequence and age of the pyroclastic products in the Campi Flegrei area of Southern Italy. The Museum Breccia cannot be the early phase of the Campanian Ignimbrite, as was previously believed, but is from a smaller and later eruption with an age of approximately 17,900 y B.P. This date also precludes its correlation with the Neapolitan Yellow Tuff (12,000 y B.P.). ?? 1991.

  7. Volatile compounds and sensorial characterization of wines from four Spanish denominations of origin, aged in Spanish Rebollo (Quercus pyrenaica Willd.) oak wood barrels.

    PubMed

    Fernández de Simón, Brígida; Cadahía, Estrella; Sanz, Miriam; Poveda, Pilar; Perez-Magariño, Silvia; Ortega-Heras, Miriam; González-Huerta, Carlos

    2008-10-01

    The evolution of almost 40 oak-related volatile compounds and the sensorial characteristics of red wines from four Spanish denominations of origin (DOs) (Bierzo, Toro, Ribera de Duero, and Rioja) during aging in barrels made of Rebollo oak wood, Quercus pyrenaica, were studied and compared to the same wines aged in American and French oak barrels. Each oak wood added unique and special characteristics to the wine, and in addition, each wine showed a different ability to extract the compounds, which result in these characteristics from the oak wood. In general, wines aged in Q. pyrenaica wood were characterized by high levels of eugenol, guaiacol, and other volatile phenols. In regards to compounds like cis-whiskylactone or maltol, the behavior of this wood is very similar to that of American oaks. When considering phenolic aldehydes and ketones, the levels of these compounds are intermediate between those of French and American woods and depend greatly on the type of wine. The type of oak, on the other hand, does not affect the chromatic characteristics of the wines. In sensory analysis, the biggest differences are found in the olfactory phase. Among the four DOs studied, wine aged in Q. pyrenaica presented the highest notes of wood, with more aromas of roasting, toasting, milky coffee, spices, or wine-wood interactions. The wines aged in barrels made of Q. pyrenaica wood were highly regarded, and preference was shown for them over those same wines when they had been aged in barrels of American or French oak.

  8. 75 FR 5601 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-03

    ... Aging Special Emphasis Panel, Alzheimer's Disease Genetics. Date: March 4, 2010. Time: 7:30 p.m. to 8:30... Institute on Aging Special Emphasis Panel, Drug Development for Alzheimer's Disease. Date: March 10,...

  9. Analyses of the National Institute on Aging Late-Onset Alzheimer's Disease Family Study

    PubMed Central

    Lee, Joseph H.; Cheng, Rong; Graff-Radford, Neill; Foroud, Tatiana; Mayeux, Richard

    2009-01-01

    Objective To identify putative genetic loci related to the risk of late-onset Alzheimer disease (LOAD). Design Linkage analysis and family-based and case-control association analyses from a genomewide scan using approximately 6000 single-nucleotide polymorphic markers at an average intermarker distance of 0.65 cM. Setting The National Institute on Aging Genetics Initiative for Late-Onset Alzheimer's Disease (NIA-LOAD) was created to expand the resources for studies to identify additional genes contributing to the risk for LOAD. Participants We investigated 1902 individuals from 328 families with LOAD and 236 unrelated control subjects. Main Outcome Measures Clinical diagnosis of LOAD. Results The strongest overall finding was at chromosome 19q13.32, confirming the effect of the apolipoprotein E gene on LOAD risk in the family-based and case-control analyses. However, single-nucleotide polymorphisms at the following loci were also statistically significant in 1 or more of the analyses performed: 7p22.2, 7p21.3, and 16q21 in the linkage analyses; 17q21.31 and 22q11.21 in the family-based association analysis; and 7q31.1 and 22q12.3 in the case-control analysis. Positive associations at 7q31.1 and 20q13.33 were also significant in the meta-analysis results in a publicly available database. Conclusions Several additional loci may harbor genetic variants associated with LOAD. This data set provides a wealth of phenotypic and genotypic information for use as a resource in discovery and confirmatory research. PMID:19001172

  10. Graduates' Perspectives on a National Specialized Program in Social Work and Aging

    ERIC Educational Resources Information Center

    Greenfield, Emily A.; Shpiegel, Svetlana

    2012-01-01

    Recognizing the growing need for social workers with specialized training in aging, the Hartford Partnership Program for Aging Education (HPPAE) has developed as a nationwide initiative to enhance aging education for master's-level social work students. This study presents a content analysis of answers to 2 open-ended questions in a national…

  11. On the origin and tectonic significance of the intra-plate events of Grenvillian-type age in South America: A discussion

    NASA Astrophysics Data System (ADS)

    Cordani, Umberto G.; Fraga, Leda Maria; Reis, Nelson; Tassinari, Colombo C. G.; Brito-Neves, Benjamim B.

    2010-01-01

    The objective of this article is to examine the available evidence of intra-plate tectonic episodes of "Grenvillian-type age", affecting the South-American continent, assessing their possible causal correlation with the tectonic processes occurring within the orogenic belts active at their margins. For the Amazonian Craton, the active margin is represented by the Rondonian-San Ignacio and Sunsas belts. However, active margins of similar age are not recognized for the São Francisco and the Rio de La Plata Cratons, and the intra-plate events over them could be reflections of the Kibaran, Irumide or Namaqua orogenic collisions in Africa. Grenvillian-type age events over the Amazonian Craton can be described in four different aspects: shearing and tectonic reactivation along zones of weakness, cratogenic granitic magmatism, alkaline ring complexes, and pervasive regional heating in some localized regions. The first of them may reflect the compressional stresses at active margins, however the others may have different origins. Within the type-region of the K'Mudku tectono thermal episode, mylonites and pseudotachylites cut across the regional granitoid and metamorphic rocks. These shear belts developed under low-to-moderate temperature conditions, that induced resetting of K-Ar and Rb-Sr mineral ages. In the São Francisco Craton, extensional and compressional events of Grenvillian-type age are well registered by the structural features exhibited by the sedimentary rocks of the Espinhaço Supergroup. For example, in Bahia state, an Appalachian-style structure is observed, with large synclines and anticlines extending along hundreds of kilometers. The major difference between the Amazonian and the Congo-São Francisco Cratons is related to heat originated from the Earth's interior. Amazonia exhibits very large areas heated up to 350-400 °C, where the K'Mudku thermo-tectonic episodes were detected. In addition, Amazonia comprises a large amount of cratogenic granitic

  12. Association of age and admission mean arterial blood pressure in patients with stroke-data from a national stroke registry.

    PubMed

    Eizenberg, Yoav; Koton, Silvia; Tanne, David; Grossman, Ehud

    2016-05-01

    Elevated blood pressure (BP) upon admission is common in patients with ischemic stroke (IS) and intracerebral hemorrhage (ICH). Older patients have a higher prevalence of stroke, but data on admission mean arterial pressure (MAP) patterns in older patients with stroke are scarce. All 6060 patients with IS (72%), ICH (8%) and transient ischemic attack (TIA; 20%) with data on BP and hypertension status on admission in the National Acute Stroke Israeli Registry were included. Admission MAP in the emergency department was studied by age group (<60, 60-74 and ⩾75 years) and stroke type. Linear regression models for admission MAP were produced, including age group, gender, hypertension status and stroke severity as covariates. Interactions between hypertension and age were assessed. Lower MAP (s.d.) was associated with older ages in hypertensive patients (113 (18) mm Hg for age <60 years, 109 (17) for age 60-74 years and 108 (19) for age ⩾75 years, P<0.0001) but not in non-hypertensive IS patients. Among patients with ICH and TIA, a significant negative association of MAP with age was observed for hypertensive patients (P=0.015 and P=0.023, respectively), whereas a significant positive association with age was found in non-hypertensive patients (P=0.023 and P=0.038, respectively). In adjusted regression models, MAP was significantly associated with hypertension in IS, ICH and TIA patients. The interaction between hypertension and age was significantly associated with MAP in IS and ICH patients. In hypertensive patients, the average admission MAP was lower in persons at older ages.

  13. The rotational origin and state of the whole: its relation to growth, fertility, aging, death, and diseases.

    PubMed

    Pierpaoli, Walter

    2005-12-01

    The purpose of my report is to synthetically summarize the concept of the rotatory essence of the Whole and to bring evidence that while aging responds to a precise inner "program" of the mammalian and any other species' "brain," acceleration of aging and all diseases are simply the direct outcome of a desynchronization of our inner "clock" with respect to the precise periodicity and hormone-integrated rhythmicity of the solar system. Those neuroendocrine, hormonal derangements of our inner clock are easily detectable and inevitably anticipate even by decades the onset of all diseases (autoimmune, cardiovascular, neurodegenerative, neoplastic). I will introduce those interventions capable of detecting early alterations and of restoring hormonal rhythmicity, which will consequently restore immunological surveillance in a positive cascade sequence. PMID:16399884

  14. Use of radium isotopes to determine the age and origin of radioactive barite at oil-field production sites

    USGS Publications Warehouse

    Zielinski, R.A.; Otton, J.K.; Budahn, J.R.

    2001-01-01

    Radium-bearing barite (radiobarite) is a common constituent of scale and sludge deposits that form in oil-field production equipment. The barite forms as a precipitate from radium-bearing, saline formation water that is pumped to the surface along with oil. Radioactivity levels in some oil-field equipment and in soils contaminated by scale and sludge can be sufficiently high to pose a potential health threat. Accurate determinations of radium isotopes (226Ra+228Ra) in soils are required to establish the level of soil contamination and the volume of soil that may exceed regulatory limits for total radium content. In this study the radium isotopic data are used to provide estimates of the age of formation of the radiobarite contaminant. Age estimates require that highly insoluble radiobarite approximates a chemically closed system from the time of its formation. Age estimates are based on the decay of short-lived 228Ra (half-life=5.76 years) compared to 226Ra (half-life=1600 years). Present activity ratios of 228Ra/226Ra in radiobarite-rich scale or highly contaminated soil are compared to initial ratios at the time of radiobarite precipitation. Initial ratios are estimated by measurements of saline water or recent barite precipitates at the site or by considering a range of probable initial ratios based on reported values in modern oil-field brines. At sites that contain two distinct radiobarite sources of different age, the soils containing mixtures of sources can be identified, and mixing proportions quantified using radium concentration and isotopic data. These uses of radium isotope data provide more description of contamination history and can possibly address liability issues. Copyright ?? 2000 .

  15. Occurrence and origin of minerals in a chamosite-bearing coal of Late Permian age, Zhaotong, Yunnan, China

    USGS Publications Warehouse

    Dai, S.; Chou, C.-L.

    2007-01-01

    The minerals found in the no.5 coal (Late Permian) from the Zhaotong Coalfield, Yunnan Province, southwestern China, have been examined and found to consist mainly of kaolinite, pyrite, chamosite, quartz, and calcite, with trace amounts of illite and mixed-layer illite-smectite. The proportion of chamosite in clay minerals ranges from 32 to 56 wt%, with an average of 46 wt%. Chamosite is distributed not only in collodetrinite, but also occurs as cell fillings in fusinite, semifusinite, and telinite. The high content and mode of occurrence of chamosite in this mine indicate its formation by interaction of kaolinite with Fe-Mg-rich fluids during early diagenesis. Except for a minor amount of terfigenous quartz, most quartz is of authigenic origin and formed from kaolinite desilication. The calcite content of the no. 5 coal is 1.4-6.3% (with an average of 3%) and is distributed in collodetrinite and as cell fillings of coal-forming plants. Calcite originated from seawater invasion during peat accumulation. Pyrite occurs in several ways: as massive, framboidal, isolated enhedral/ anhedral, and euhedral forms. In addition, the presence of a large amount of pyritized red algae provides strong evidence of seawater invasion during peat accumulation. The red algae may have played an important role in the enrichment of sulfur in the coal. The characteristic assemblage of minerals in this mine resulted from a unique basinal environment in which the mineral matter was derived from a basaltic source region, volcanic activity, and seawater transgression during coal formation.

  16. The unexpected outcomes of anti-aging, rejuvenation, and life extension studies: an origin of modern therapies.

    PubMed

    Stambler, Ilia

    2014-06-01

    The search for life-extending interventions has been often perceived as a purely academic pursuit, or as an unorthodox medical enterprise, with little or no practical outcome. Yet, in fact, these studies, explicitly aiming to prolong human life, often constituted a formidable, though hardly ever acknowledged, motivation for biomedical research and discovery. At least several modern biomedical fields have originated directly from rejuvenation and life extension research: (1) Hormone replacement therapy was born in Charles-Edouard Brown-Séquard's rejuvenation experiments with animal gland extracts (1889). (2) Probiotic diets originated in Elie Metchnikoff's conception of radically prolonged "orthobiosis" (c. 1900). (3) The development of clinical endocrinology owed much to Eugen Steinach's "endocrine rejuvenation" operations (c. 1910s-1920s). (4) Tissue transplantations in humans (allografts and xenografts) were first widely performed in Serge Voronoff's "rejuvenation by grafting" experiments (c. 1910s-1920s). (5) Tissue engineering was pioneered during Alexis Carrel's work on cell and tissue immortalization (c. 1900-1920). (6) Cell therapy (and particularly human embryonic cell therapy) was first widely conducted by Paul Niehans for the purposes of rejuvenation as early as the 1930s. Thus, the pursuit of life extension and rejuvenation has constituted an inseparable and crucial element in the history of biomedicine. Notably, the common principle of these studies was the proactive maintenance of stable, long-term homeostasis of the entire organism.

  17. The Relationship between Functional Capacity and Community Responsibilities in Middle-aged and Older Latinos of Mexican Origin with Chronic Psychosis

    PubMed Central

    Cardenas, Veronica; Mausbach, Brent T.; Barrio, Concepcion; Bucardo, Jesus; Jeste, Dilip; Patterson, Thomas

    2008-01-01

    The purpose of this study was to examine the relationship between scores on the UCSD Performance-based Skills Assessment (UPSA), a performance-based measure of functional capacity, and level of patient community responsibilities (i.e., work for pay; volunteer work; attend school; household duties) in a Latino sample. Participants were 58 middle-aged and older Latinos of Mexican origin (mean age = 48.8 years) with a diagnosis of schizophrenia or schizoaffective disorder. We conducted an analysis of covariance (ANCOVA), controlling for age, symptoms of psychosis, and participant language, to determine if greater participation in community responsibilities was associated with higher functional capacity, as measured by the UPSA. Results indicated significant group differences in UPSA scores (F = 5.11, df = 2,51; p = .009), with patients reporting only a single community responsibility having significantly higher UPSA scores than those reporting zero community responsibilities (p = .016) and those reporting two responsibilities scoring significantly higher than those reporting zero community responsibility (p = .008). There were no differences found between those reporting one and those reporting two community responsibilities (p= .256). In contrast, no group differences were observed on the Dementia Rating Scale, a global measure of cognitive functioning (F = 2.14, df = 2,51; p = .128). These results provide initial support for the validity of the UPSA in Latino patients of Mexican origin, and suggest that improvement in functional capacity (i.e., UPSA scores) may be associated with increased capacity for greater community involvement in this population. PMID:17936585

  18. The relationship between functional capacity and community responsibilities in middle-aged and older Latinos of Mexican origin with chronic psychosis.

    PubMed

    Cardenas, Veronica; Mausbach, Brent T; Barrio, Concepcion; Bucardo, Jesus; Jeste, Dilip; Patterson, Thomas

    2008-01-01

    The purpose of this study was to examine the relationship between scores on the UCSD Performance-based Skills Assessment (UPSA), a performance-based measure of functional capacity, and level of patient community responsibilities (i.e., work for pay; volunteer work; attend school; household duties) in a Latino sample. Participants were 58 middle-aged and older Latinos of Mexican origin (mean age=48.8 years) with a diagnosis of schizophrenia or schizoaffective disorder. We conducted an analysis of covariance (ANCOVA), controlling for age, symptoms of psychosis, and participant language, to determine if greater participation in community responsibilities was associated with higher functional capacity, as measured by the UPSA. Results indicated significant group differences in UPSA scores (F=5.11, df=2, 51; p=.009), with patients reporting only a single community responsibility having significantly higher UPSA scores than those reporting zero community responsibilities (p=.016) and those reporting two responsibilities scoring significantly higher than those reporting zero community responsibility (p=.008). There were no differences found between those reporting one and those reporting two community responsibilities (p=.256). In contrast, no group differences were observed on the Dementia Rating Scale, a global measure of cognitive functioning (F=2.14, df=2, 51; p=.128). These results provide initial support for the validity of the UPSA in Latino patients of Mexican origin, and suggest that improvement in functional capacity (i.e., UPSA scores) may be associated with increased capacity for greater community involvement in this population.

  19. Aspen Ecology in Rocky Mountain National Park: Age Distribution, Genetics, and the Effects of Elk Herbivory

    USGS Publications Warehouse

    Zeigenfuss, Linda C.; Binkley, Dan; Tuskan, Gerald A.; Romme, William H.; Yin, Tongming; DiFazio, Stephen; Singer, Francis J.

    2008-01-01

    Lack of recruitment and canopy replacement of aspen (Populus tremuloides) stands that grow on the edges of grasslands on the low-elevation elk (Cervus elaphus) winter range of Rocky Mountain National Park (RMNP) in Colorado have been a cause of concern for more than 70 years. We used a combination of traditional dendrochronology and genetic techniques as well as measuring the characteristics of regenerating and nonregenerating stands on the elk winter range to determine when and under what conditions and estimated elk densities these stands established and through what mechanisms they may regenerate. The period from 1975 to 1995 at low elevation on the east side had 80-95 percent fewer aspen stems than would be expected based on the trend from 1855 through 1965. The age structure of aspen in the park indicates that the interacting effects of fires, elk population changes, and livestock grazing had more-or-less consistent effects on aspen from 1855 to 1965. The lack of a significant change in aspen numbers in recent decades in the higher elevation and west side parts of the park supports the idea that the extensive effects of elk browsing have been more important in reducing aspen numbers than other factors. The genetic variation of aspen populations in RMNP is high at the molecular level. We expected to find that most patches of aspen in the park were composed of a single clone of genetically identical trees, but in fact just 7 percent of measured aspen patches consisted of a single clone. A large frequency of polyploid (triploid and tetraploid) genotypes were found on the low elevation, east-side elk winter range. Nonregenerating aspen stands on the winter range had greater annual offtake, shorter saplings, and lower density of mid-height (1.5-2.5 m) saplings than regenerating stands. Overwinter elk browsing, however, did not appear to inhibit the leader length of aspen saplings. The winter range aspen stands of RMNP appear to be highly resilient in the face of

  20. AGE AND ORIGIN OF BASE- AND PRECIOUS-METAL VEINS OF THE COEUR D'ALENE MINING DISTRICT, IDAHO

    SciTech Connect

    Fleck, R J; Criss, R E; Eaton, G F; Cleland, R W; Wavra, C S; Bond, W D

    2000-11-07

    Ore-bearing quartz-carbonate veins of the Coeur d'Alene mining district yield {sup 87}Sr/{sup 86}Sr ratios of 0.74 to >1.60 for low-Rb/Sr, carbonate gangue minerals, similar to current ranges measured in Middle Proterozoic, high-Rb/Sr rocks of the Belt Supergroup. Stable-isotope and fluid-inclusion studies establish a genetic relationship between vein formation and metamorphic-hydrothermal systems of the region. These extraordinary {sup 87}Sr/{sup 86}Sr ratios require accumulation of radiogenic {sup 87}Sr in a high Rb/Sr system over an extended period prior to incorporation of Sr into the veins by hydrothermal processes. Evaluation of the age and composition of potential sources of highly radiogenic Sr indicates that the ore-bearing veins of the Coeur d'Alene district formed within the last 200 Ma from components scavenged from sedimentary and metasedimentary rocks of the Belt Supergroup, the primary host-rocks of the district. These results are consistent with a Cretaceous or Early Tertiary age for these veins. Pb-Zn deposits that yield Pb isotope, K-Ar, and Ar-Ar results indicative of a Proterozoic age probably formed during deposition or diagenesis of the Belt Supergroup at 1350-1500 Ma, possibly as Sullivan-type syngenetic deposits. K-Ar and Rb-Sr apparent ages and {delta}{sup 18}O values of Belt Supergroup rocks decrease southward from the Coeur d'Alene district toward the Idaho batholith, normal to the trends of metamorphic isograds, fold axes, foliation, and the major reverse faults of the district. Isoclinal folding, thrust faulting, high-temperature metamorphism, granitic plutonism, and regional-scale metamorphic-hydrothermal activity is documented in the region between 140 Ma and 45 Ma, but no similar combination of events is recognized for Late Proterozoic time. Combined with Sr results from the veins, the evidence strongly favors formation of the ore-bearing carbonate veins of the district by fluids related to a complex metamorphic-hydrothermal system

  1. A Historical Analysis of the Quest for the Origins of Aging Macula Disorder, the Tissues Involved, and Its Terminology

    PubMed Central

    de Jong, Paulus T.V.M.

    2016-01-01

    Although ocular tissues involved in aging macula disorder (AMD) were already known in 300 BC, the last type of photoreceptors was discovered only 10 years ago. The earliest descriptions of AMD appeared around 1850. It took over 150 years, till a clearer concept of AMD was formulated and even longer to grasp its pathophysiology. The uncertainty of researchers about the pathogenesis of AMD over the last century is reflected in its changing terminology. The evolution of this terminology is provided in a table to afford the reader a better insight into explanations proposed by researchers during this quest. PMID:27812291

  2. Isolation of Left Common Carotid Artery with Its Origin Proximal to Patent Ductus Arteriosus Presenting in Adult Age

    PubMed Central

    Joshi, Anagha R.; Joshi, Saurabh; Kale, Kiran; Jain, Rahul; Bava, Jernail Singh

    2016-01-01

    Anomalies of aortic arch are a common occurrence. Such anomalies of right sided aortic arch with its various branching patterns are of clinical importance. Rarer anomalies include isolation (deficient connection) of either left subclavian artery or left common carotid artery; that is, they do not have their origin from aorta or its major branches. We present a case of an 18-year-old male who presented with gradual onset pulsatile swelling with bruit in neck on left side and was evaluated by CT brain and neck angiography. CT angiography revealed right sided aortic arch with aberrant left subclavian artery and isolated left common carotid artery. Very few cases of such an anomaly have been documented in the literature but none in an adult. PMID:27213071

  3. Occurrence and origin of minerals in a chamosite-bearing coal of Late Permian age, Zhaotong, Yunnan, China

    SciTech Connect

    Dai, S.; Chou, C.L.

    2007-08-15

    The minerals found in the no. 5 coal (Late Permian) from the Zhaotong Coalfield, Yunnan Province, southwestern China, have been examined and found to consist mainly of kaolinite, pyrite, chamosite, quartz, and calcite, with trace amounts of illite and mixed-layer illite-smectite. The proportion of chamosite in clay minerals ranges from 32 to 56 wt%, with an average of 46 wt%. Chamosite is distributed not only in collodetrinite, but also occurs as cell fillings in fusinite, semifusinite, and telinite. The high content and mode of occurrence of chamosite in this mine indicate its formation by interaction of kaolinite with Fe-Mg-rich fluids during early diagenesis. Except for a minor amount of terrigenous quartz, most quartz is of authigenic origin and formed from kaolinite desilication. The calcite content of the no. 5 coal is 1.4-6.3% (with an average of 3%) and is distributed in collodetrinite and as cell fillings of coal-forming plants. Calcite originated from seawater invasion during peat accumulation. Pyrite occurs in several ways: as massive, framboidal, isolated enhedral/anhedral, and euhedral forms. In addition, the presence of a large amount of pyritized red algae provides strong evidence of seawater invasion during peat accumulation. The red algae may have played an important role in the enrichment of sulfur in the coal. The characteristic assemblage of minerals in this mine resulted from a unique basinal environment in which the mineral matter was derived from a basaltic source region, volcanic activity, and seawater transgression during coal formation.

  4. Constraining the age of the NGC 4565 H I disk WARP: Determining the origin of gas WARPS

    SciTech Connect

    Radburn-Smith, David J.; Dalcanton, Julianne J.; Stilp, Adrienne M.; De Jong, Roelof S.; Streich, David; Bell, Eric F.; Monachesi, Antonela; Dolphin, Andrew E.; Holwerda, Benne W.; Bailin, Jeremy

    2014-01-01

    We have mapped the distribution of young and old stars in the gaseous H I warp of NGC 4565. We find a clear correlation of young stars (<600 Myr) with the warp but no coincident old stars (>1 Gyr), which places an upper limit on the age of the structure. The formation rate of the young stars, which increased ∼300 Myr ago relative to the surrounding regions, is (6.3{sub −1.5}{sup +2.5})×10{sup −5} M {sub ☉} yr{sup –1} kpc{sup –2}. This implies a ∼60 ± 20 Gyr depletion time of the H I warp, similar to the timescales calculated for the outer H I disks of nearby spiral galaxies. While some stars associated with the warp fall into the asymptotic giant branch (AGB) region of the color-magnitude diagram, where stars could be as old as 1 Gyr, further investigation suggests that they may be interlopers rather than real AGB stars. We discuss the implications of these age constraints for the formation of H I warps and the gas fueling of disk galaxies.

  5. Social Work Faculty's Knowledge of Aging: Results from a National Sample

    ERIC Educational Resources Information Center

    Wang, Donna S.; Chonody, Jill M.; Krase, Kathryn

    2013-01-01

    Social work students have reported in previous studies that they receive insufficient coursework and training to work effectively with older adults. A critical factor in these deficiencies may be the level of knowledge of social work faculty. This study sought to assess social work faculty's knowledge of aging using the Knowledge of Aging for…

  6. Across all solid organs, adolescent age recipients have worse transplant organ survival than younger age children: A US national registry analysis.

    PubMed

    Dharnidharka, Vikas R; Lamb, Kenneth E; Zheng, Jie; Schechtman, Kenneth B; Meier-Kriesche, Herwig-Ulf

    2015-08-01

    Univariate analyses suggest that adolescents have worse long-term allograft survival versus younger children across different SOT. This study's objective was to determine whether multivariate analyses of a large national database recording all deceased SOT (KI; LI; HR; LU) also show worse adolescent allograft survival in the different organs. Using data from the national Scientific Registry for Transplant Recipients in the USA for pediatric primary SOT from 1989 to 2010, we calculated median half-lives and constructed K-M graft survival curves. Recipient age at transplant (<12 or adolescent 12-17 yr) was fitted with other identical covariates into multivariate Cox proportional hazards models. In all SOT recipients, unadjusted graft survival curves demonstrated better graft survival for adolescents initially, followed by crossing of the lines, such that adolescent SOT recipients had worse survival after one yr (KI), 4.6 yr (LI), 4.4 yr (HR), and 1.6 yr (LU). Multivariate models of the post-cross period showed a significantly higher AHR for worse graft survival in adolescent age across all four SOTs: AHR 1.400 (KI), 1.958 (LI), 1.414 (HR), and 1.576 (LU). Improving adolescent long-term outcomes across all four organs will be a defining issue in the future.

  7. Age-Related Changes in the Cardiometabolic Profiles in Singapore Resident Adult Population: Findings from the National Health Survey 2010

    PubMed Central

    Loh, Tze Ping; Ma, Stefan; Heng, Derrick; Khoo, Chin Meng

    2016-01-01

    We describe the centile trends of the blood pressure, glycemia and lipid profiles as well as renal function of a representative population who participated in the Singapore National Health Survey in 2010. Representative survey population was sampled in two phases, first using geographical/ residential dwelling type stratification, followed up ethnicity. 2,407 survey participants without any self-reported medical or medication history for diabetes mellitus, hypertension and dyslipidemia were included in this analysis. All biochemistry analyses were performed on Roche platforms. After excluding outliers using Tukey's criteria, the results of the remaining participants were subjected to lambda-mu-sigma (LMS) analysis. In men, systolic blood pressure increased linearly with age. By contrast, an upward inflection around late 40s was seen in women. The diastolic blood pressure was highest in men in the late 30s-50s age group, and in women in the late 50s-60s age group. All glycemia-related parameters, i.e. fasting and 2-hour plasma glucose and HbA1c concentrations increased with age, although the rate of increase differed between the tests. Total cholesterol and LDL-cholesterol concentrations increased with age, which became attenuated between the early 30s and late 50s in men, and declined thereafter. In women, total cholesterol and LDL-cholesterol concentrations gradually increased with age until late 30s, when there is an upward inflection, plateauing after late 50s. Our findings indicate that diagnostic performance of laboratory tests for diabetes may be age-sensitive. Unfavourable age-related cardiovascular risk profiles suggest that the burden of cardiovascular disease in this population will increase with aging population. PMID:27570971

  8. Age-Related Changes in the Cardiometabolic Profiles in Singapore Resident Adult Population: Findings from the National Health Survey 2010.

    PubMed

    Loh, Tze Ping; Ma, Stefan; Heng, Derrick; Khoo, Chin Meng

    2016-01-01

    We describe the centile trends of the blood pressure, glycemia and lipid profiles as well as renal function of a representative population who participated in the Singapore National Health Survey in 2010. Representative survey population was sampled in two phases, first using geographical/ residential dwelling type stratification, followed up ethnicity. 2,407 survey participants without any self-reported medical or medication history for diabetes mellitus, hypertension and dyslipidemia were included in this analysis. All biochemistry analyses were performed on Roche platforms. After excluding outliers using Tukey's criteria, the results of the remaining participants were subjected to lambda-mu-sigma (LMS) analysis. In men, systolic blood pressure increased linearly with age. By contrast, an upward inflection around late 40s was seen in women. The diastolic blood pressure was highest in men in the late 30s-50s age group, and in women in the late 50s-60s age group. All glycemia-related parameters, i.e. fasting and 2-hour plasma glucose and HbA1c concentrations increased with age, although the rate of increase differed between the tests. Total cholesterol and LDL-cholesterol concentrations increased with age, which became attenuated between the early 30s and late 50s in men, and declined thereafter. In women, total cholesterol and LDL-cholesterol concentrations gradually increased with age until late 30s, when there is an upward inflection, plateauing after late 50s. Our findings indicate that diagnostic performance of laboratory tests for diabetes may be age-sensitive. Unfavourable age-related cardiovascular risk profiles suggest that the burden of cardiovascular disease in this population will increase with aging population. PMID:27570971

  9. Effects of Smoking on Menopausal Age: Results From the Korea National Health and Nutrition Examination Survey, 2007 to 2012

    PubMed Central

    Yang, Hee Jung; Suh, Pae Sun; Kim, Soo Jeong; Lee, Soon Young

    2015-01-01

    Objectives: Decreased fertility and impaired health owing to early menopause are significant health issues. Smoking is a modifiable health-related behavior that influences menopausal age. We investigated the effects of smoking-associated characteristics on menopausal age in Korean women. Methods: This study used data from the Korea National Health and Nutrition Examination Survey from 2007 to 2012. Menopausal age in relation to smoking was analyzed as a Kaplan-Meier survival curve for 11 510 women (aged 30 to 65 years). The risk of entering menopause and experiencing early menopause (before age 48) related to smoking were assessed using a Cox proportional hazards model. Results: The menopausal age among smokers was 0.75 years lower than that among non-smokers (p<0.001). The results of the Cox proportional hazards model showed pre-correction and post-correction risk ratios for entering menopause related to smoking of 1.26 (95% confidence interval [CI], 1.09 to 1.46) and 1.27 (95% CI, 1.10 to 1.47), respectively, and pre-correction and post-correction risk ratios for experiencing early menopause related to smoking of 1.36 (95% CI, 1.03 to 1.80) and 1.40 (95% CI, 1.05 to 1.85), respectively. Conclusions: Smokers reached menopause earlier than non-smokers, and their risk for experiencing early menopause was higher. PMID:26265667

  10. When Do Laws Matter? National Minimum-Age-of-Marriage Laws, Child Rights, and Adolescent Fertility, 1989–2007

    PubMed Central

    Kim, Minzee; Longhofer, Wesley; Boyle, Elizabeth Heger; Nyseth, Hollie

    2014-01-01

    Using the case of adolescent fertility, we ask the questions of whether and when national laws have an effect on outcomes above and beyond the effects of international law and global organizing. To answer these questions, we utilize a fixed-effect time-series regression model to analyze the impact of minimum-age-of-marriage laws in 115 poor- and middle-income countries from 1989 to 2007. We find that countries with strict laws setting the minimum age of marriage at 18 experienced the most dramatic decline in rates of adolescent fertility. Trends in countries that set this age at 18 but allowed exceptions (for example, marriage with parental consent) were indistinguishable from countries that had no such minimum-age-of-marriage law. Thus, policies that adhere strictly to global norms are more likely to elicit desired outcomes. The article concludes with a discussion of what national law means in a diffuse global system where multiple actors and institutions make the independent effect of law difficult to identify. PMID:25525281

  11. Age and origin of base and precious metal veins of the Coeur d'Alene mining district, Idaho

    USGS Publications Warehouse

    Fleck, R.J.; Criss, R.E.; Eaton, G.F.; Cleland, R.W.; Wavra, C.S.; Bond, W.D.

    2002-01-01

    Ore-bearing quartz-carbonate veins of the Coeur d'Alene mining district yield 87Sr/86Sr ratios of 0.74 to >1.60 for low Rb/Sr, carbonate gangue minerals, similar to current ranges measured in Middle Proterozoic, high Rb/Sr rocks of the Belt Supergroup. Stable isotope and fluid inclusion studies establish a genetic relationship between vein formation and metamorphic-hydrothermal systems of the region. These extraordinary 87Sr/86Sr ratios require accumulation of radiogenic 87Sr in a high Rb/Sr system over an extended period prior to incorporation of Sr into the hydrothermal veins. Evaluation of the age and composition of potential sources of highly radiogenic Sr indicates that the ore-bearing veins of the Coeur d'Alene district formed during the Cretaceous from components scavenged from rocks of the Belt Supergroup, the primary host rocks of the district. Proterozoic Pb isotope ratios observed in galena from many Coeur d'Alene veins were established when Pb separated from uranium during deposition or diagenesis of the Belt Supergroup at 1400 to 1500 Ma, possibly as disseminated syngenetic deposits. K-Ar and Rb-Sr apparent ages and ??18O values of Belt Supergroup rocks decrease from the Coeur d'Alene district toward the Idaho and Kaniksu batholiths, approximately normal to the trends of metamorphic isograds, fold axes, foliation, and the major reverse faults of the district. Isoclinal folding, thrust faulting, high-temperature metamorphism, granitic plutonism, and regional-scale metamorphic-hydrothermal activity is documented in the region between 140 and 45 Ma, representing the only such combination of events in the Coeur d'Alene region subsequent to about 1300 Ma. The Sr and oxygen results and geologic evidence favor formation of the ore-bearing carbonate veins by fluids related to a complex metamorphic-hydrothermal system during the Cretaceous. Pb with Proterozoic isotopic compositions was probably mobilized and incorporated like other metals into the hydrothermal

  12. 78 FR 66369 - National Institute on Aging; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-05

    ..., Bethesda, MD 20814, which was published in the Federal Register on August 23, 2013, 52552 FR 164. Meeting... Notice is hereby given of a change in the meeting of the Neuroscience of Aging Review Committee,...

  13. 75 FR 54159 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-03

    ... Emphasis Panel, Stem Cells and Genomic Integrity Through Senescense. Date: November 3, 2010. Time: 12 p.m....nih.gov . (Catalogue of Federal Domestic Assistance Program Nos. 93.866, Aging Research,...

  14. Age, Growth and Reproduction of the Eastern Mudminnow (Umbra pygmaea) at the Great Swamp National Wildlife Refuge, New Jersey.

    USGS Publications Warehouse

    Panek, Frank; Weis, Judith S.

    2012-01-01

    Umbra pygmaea DeKay (Eastern Mudminnow) is one of four species of Umbridae in North America. There is little published life-history information on the species within its native range, particularly on age, growth, and reproduction. This study focuses on these aspects of the life history of this fish at the Great Swamp National Wildlife Refuge in Morris County, NJ. A total of 336 fish of seven species was collected from June 1978 through May 1979, with the Eastern Mudminnow comprising 74% of the total. The average annual growth increment in total length for the Eastern Mudminnow was 15.3 2.06 mm, with age-1 fish averaging 40 mm total length and age-5 fish, the oldest collected, averaging 107 mm total length. The length-weight relationship was log10W = -5.291 + 3.182 log10TL mm for males and log10W = -4.999 + 3.032 log10TL mm for females. We observed no statistically significant sexually dimorphic differences in length-weight relationships in this population. The ratio of females to males increased from a low of 0.6 (predominance of male fish) at age-1 to a high of 4.6 (predominance of females) at age-5. Annual mortality for age 2–5 fish ranged from 40–76% with a mean of 59 13%. Age-specific fecundity estimates ranged from 250 eggs/female at age-1 to 2168 eggs/female at age-5. The relationship of number of mature ova to age was best described by the exponential function y = 149.29e0.5287x, where y = age-specific fecundity and x = age in years. Ova ranged from 0.1–0.2 mm in diameter in June and July and averaged 1.41 0.1 mm (range = 1.29–1.62 mm) in early February prior to spawning. Peak spawning occurred in mid-April at temperatures of 9–12 °C, and all females were spent by late April (13–15 °C).

  15. Origin and age of erosional gullies and ridges in loess of central Alaska--Evidence of ancient global warming

    SciTech Connect

    Pewe, T.L. . Geology Dept.)

    1992-01-01

    The lower and especially middle slopes of many of the rolling hills of the Yukon-Tanana Upland are blanketed with 3 to 20 m of olive gray, airfall, massive loess which is dissected by parallel gullies 10--15 m deep and 100--200 m long that trend downslope. The gullies and ridges occur over hundreds of square kilometers. It is believed the eroded and gullied loess topography originated during the last interglacial of 125 ka. The climatic warming led to: (1) melting of the ground ice in permafrost and thermokarst activity, and (2) to greatly reduced loess deposition. The author believes that most of the water to initiate loess cutting came from the melting of the great amount of ground ice in the permafrost. The last interglacial time was warm enough to melt the ground ice and initiate catastrophic thermokarst activity in easily erodible loess on hillsides. If the gullying had been in Holocene time, the ridges and gullies would be more sharp sided and the ridges relatively flat-topped, as is characteristic of trenched loess, even after centuries. On the other hand, gullies and ridges formed early during the Eva Interglacial would tend to be subdued by creep and solifluction during the 100,000 year Wisconsin cold interval. Such is illustrated by the downbending of loess and tephra on the sides of loess ridges. If the loess ridges were formed in Holocene time, they would include horizontal loess deposits of Wisconsin and perhaps early Holocene times inasmuch as they would be covering a nongullied topography. Examination reveals that there are no Wisconsin and Holocene loess deposits on the steep side slopes of the uppermost part of the ridges and other erosional remnants. The Subarctic Brown Forest soil is interglacial and, started to form anywhere from 10,000 to 8,000 years ago. The soil profile developed on the pre-soil ridge topography; therefore, the time of ridge and gully formation is pre-10,000 years.

  16. A reappraisal of the age, origin and structural setting of sulphide mineralisation in the UK North Pennines Orefield

    NASA Astrophysics Data System (ADS)

    Holdsworth, Bob; Dempsey, Eddie; Selby, David; Le Cornu, Chris; Young, Brian

    2015-04-01

    The North Pennines Orefield (NPO) is centred on the Alston block, a structural high of fractured Carboniferous sedimentary rocks that unconformably overlie a Devonian age (ca. 399 Ma) granite pluton buried at shallow depths (<0.5 km). The orefield has long been considered to be a classic example of a Mississippi Valley Type (MVT) deposit where the source of the metals and sulphur are derived by hydrothermal leaching of the host sedimentary (carbonate-rich) rocks. The vein-hosted part of the orefield consists of linked systems of shear and tensile fractures with a variety of regionally recognised orientations (ESE-WNW Quarter Point, NE-SW, NW-SE Cross Veins). These are associated with lead (galena), iron (pyrite, pyrrhotite, marcasite), copper (chalcopyrite), zinc (sphalerite), fluorite, barite and quartz mineralization. New Rhenium-Osmium (Re-Os) isotope geochemical analysis of the vein-hosted pyrite mineralization suggests that: (i) the metalliferous ores of the NPO formed ca. 294Ma (earliest Permian); and (ii) that they carry an initial Os ratio indicative of a mantle source similar to that indicated by the initial Os ratio of the Whin Sill dolerite suite (emplacement ages ca. 297-294 Ma). New field observations and stress inversion analyses show that at least two regional deformation events are recognised in the Carboniferous host rocks of the NPO. A initial phase of Late Carboniferous ('Variscan') N-S compression pre-dates mineralisation and leads to formation of the NW-SE fractures, initiation of the Burtreeford Disturbance as a N-S fault and compressional reactivation of the previously extensional E-W Lunedale Fault. A later phase of dextral transtension (NNE-SSW extension, ESE-WNW compression) leads to the formation of the ESE-WNW and NE-SW veins, together with compressional reactivation of the Burtreeford Disturbance and Lunedale Fault. Field and microstructural analyses show that the transtensional deformation is synchronous with the main phases of NPO

  17. Dark-ages reionization & galaxy formation simulation VI: The origins and fate of the highest known redshift galaxy

    NASA Astrophysics Data System (ADS)

    Mutch, Simon J.; Liu, Chuanwu; Poole, Gregory B.; Geil, Paul M.; Duffy, Alan R.; Trenti, Michele; Oesch, Pascal A.; Illingworth, Garth D.; Mesinger, Andrei; Wyithe, J. Stuart B.

    2016-09-01

    Using Hubble data, including new grism spectra, Oesch et al. (2016) recently identified GN-z11, a MUV=-21.1 galaxy at z=11.1 (just 400 Myr after the Big Bang). With an estimated stellar mass of ˜109 M⊙, this galaxy is surprisingly bright and massive, raising questions as to how such an extreme object could form so early in the Universe. Using MERAXES, a semi-analytic galaxy formation model developed as part of the Dark-ages Reionization And Galaxy-formation Observables from Numerical Simulations (DRAGONS) programme, we investigate the potential formation mechanisms and eventual fate of GN-z11. The volume of our simulation is comparable to that of the discovery observations and possesses two analogue galaxies of similar luminosity to this remarkably bright system. Existing in the two most massive subhaloes at z=11.1 (Mvir=1.4× 1011 M⊙ and 6.7× 1010 M⊙), our model analogues show excellent agreement with all available observationally derived properties of GN-z11. Although they are relatively rare outliers from the full galaxy population at high-z, they are no longer the most massive or brightest systems by z=5. Furthermore, we find that both objects possess relatively smooth, but extremely rapid mass growth histories with consistently high star formation rates and UV luminosities at z > 11, indicating that their brightness is not a transient, merger driven feature. Our model results suggest that future wide-field surveys with JWST may be able to detect the progenitors of GN-z11 analogues out to z ˜13-14, pushing the frontiers of galaxy-formation observations to the early phases of cosmic reionization and providing a valuable glimpse of the first galaxies to reionize the Universe on large scales.

  18. Report on the United Nations World Assembly on Aging. Based on a Follow-Up Conference (Tampa, Florida, December 7, 1983).

    ERIC Educational Resources Information Center

    Briggs, Halaine-Sherin, Ed.

    This document reports the proceedings of a United Nations World Assembly on Aging follow-up conference. Presented are the following: "International Exchange Center on Gerontology: The Organization and Its Mission"; "Preface" (Sheppard); "Welcoming Telegram" (Shuman); "Overview of the World Assembly on Aging" (McDonald); "The Aging World" (Oriol);…

  19. Gold deposits of the Carolina Slate Belt, southeastern United States--Age and origin of the major gold producers

    USGS Publications Warehouse

    Foley, Nora K.; Ayuso, Robert A.

    2012-01-01

    Gold- and iron sulfide-bearing deposits of the southeastern United States have distinctive mineralogical and geochemical features that provide a basis for constructing models of ore genesis for exploration and assessment of gold resources. The largest (historic) deposits, in approximate million ounces of gold (Moz Au), include those in the Haile (~ 4.2 Moz Au), Ridgeway (~1.5 Moz Au), Brewer (~0.25 Moz Au), and Barite Hill (0.6 Moz Au) mines. Host rocks are Late Proterozoic to early Paleozoic (~553 million years old) metaigneous and metasedimentary rocks of the Carolina Slate Belt that share a geologic affinity with the classic Avalonian tectonic zone. The inferred syngenetic and epithermal-subvolcanic quartz-porphyry settings occur stratigraphically between sequences of metavolcanic rocks of the Persimmon Fork and Uwharrie Formations and overlying volcanic and epiclastic rocks of the Tillery and Richtex Formations (and regional equivalents). The Carolina Slate Belt is highly prospective for many types of gold ore hosted within quartz-sericite-pyrite altered volcanic rocks, juvenile metasedimentary rocks, and in associated shear zones. For example, sheared and deformed auriferous volcanogenic massive sulfide deposits at Barite Hill, South Carolina, and in the Gold Hill trend, North Carolina, are hosted primarily by laminated mudstone and felsic volcanic to volcaniclastic rocks. The high-sulfidation epithermal style of gold mineralization at Brewer and low-sulfidation gold ores of the Champion pit at Haile occur in breccias associated with subvolcanic quartz porphyry and within crystal-rich tuffs, ash flows, and subvolcanic rhyolite. The Ridgeway and Haile deposits are primarily epithermal replacements and feeder zones within (now) metamorphosed crystal-rich tuffs, volcaniclastic sediments, and siltstones originally deposited in a marine volcanic-arc basinal setting. Recent discoveries in the region include (1) extensions of known deposits, such as at Haile where

  20. Radiation and mortality of workers at Oak Ridge National Laboratory: positive associations for doses received at older ages.

    PubMed Central

    Richardson, D B; Wing, S

    1999-01-01

    We examined associations between low-level exposure to ionizing radiation and mortality among 14,095 workers hired at the Oak Ridge National Laboratory between 1943 and 1972. Workers at the facility were individually monitored for external exposure to ionizing radiation and have been followed through 1990 to ascertain cause of death information. Positive associations were observed between low-level exposure to external ionizing radiation and mortality. These associations were larger for doses received after 45 years of age, larger under longer lag assumptions, and primarily due to cancer causes of death. All cancer mortality was estimated to increase 4.98% [standard error (SE) = 1.5] per 10-mSv cumulative dose received after age 45 under a 10-year lag, and 7.31% (SE = 2.2) per 10-mSv cumulative dose received after age 45 under a 20-year lag. Associations between radiation dose and lung cancer were of similar magnitude to associations between radiation dose and all cancers except lung cancer. Nonmalignant respiratory disease exhibited a positive association with cumulative radiation dose received after age 45, whereas ischemic heart disease exhibited no association with radiation dose. These findings suggest increases in cancer mortality associated with low-level external exposure to ionizing radiation and potentially greater sensitivity to the carcinogenic effects of ionizing radiation with older ages at exposure. Images Figure 1 PMID:10417363

  1. The National Ignition Facility and the Golden Age of High Energy Density Science

    SciTech Connect

    Meier, W; Moses, E I; Newton, M

    2007-09-27

    The National Ignition Facility (NIF) is a 192-beam Nd:glass laser facility being constructed at the Lawrence Livermore National Laboratory (LLNL) to conduct research in inertial confinement fusion (ICF) and high energy density (HED) science. When completed, NIF will produce 1.8 MJ, 500 TW of ultraviolet light, making it the world's largest and highest-energy laser system. The NIF is poised to become the world's preeminent facility for conducting ICF and fusion energy research and for studying matter at extreme densities and temperatures.

  2. Simulating the multicellular homeostasis with a cell-based discrete receptor dynamics model: The non-mutational origin of cancer and aging.

    PubMed

    Lou, Yuting; Chen, Yu

    2016-09-01

    The purpose of the study is to investigate the multicellular homeostasis in epithelial tissues over very large timescales. Inspired by the receptor dynamics of IBCell model proposed by Rejniak et al. an on-grid agent-based model for multicellular system is constructed. Instead of observing the multicellular architectural morphologies, the diversity of homeostatic states is quantitatively analyzed through a substantial number of simulations by measuring three new order parameters, the phenotypic population structure, the average proliferation age and the relaxation time to stable homeostasis. Nearby the interfaces of distinct homeostatic phases in 3D phase diagrams of the three order parameters, intermediate quasi-stable phases of slow dynamics that features quasi-stability with a large spectrum of relaxation timescales are found. A further exploration on the static and dynamic correlations among the three order parameters reveals that the quasi-stable phases evolve towards two terminations, tumorigenesis and degeneration, which are respectively accompanied by rejuvenation and aging. With the exclusion of the environmental impact and the mutational strategies, the results imply that cancer and aging may share the non-mutational origin in the intrinsic slow dynamics of the multicellular systems. PMID:27196967

  3. Multiple imputation for national public-use datasets and its possible application for gestational age in United States Natality files.

    PubMed

    Parker, Jennifer D; Schenker, Nathaniel

    2007-09-01

    Multiple imputation (MI) is a technique that can be used for handling missing data in a public-use dataset. With MI, two or more completed versions of the dataset are created, containing possibly different but reasonable replacements for the missing data. Users analyse the completed datasets separately with standard techniques and then combine the results using simple formulae in a way that allows the extra uncertainty due to missing data to be assessed. An advantage of this approach is that the resulting public-use data can be analysed by a variety of users for a variety of purposes, without each user needing to devise a method to deal with the missing data. A recent example for a large public-use dataset is the MI of the family income and personal earnings variables in the National Health Interview Survey. We propose an approach to utilise MI to handle the problems of missing gestational ages and implausible birthweight-gestational age combinations in national vital statistics datasets. This paper describes MI and gives examples of MI for public-use datasets, summarises methods that have been used for identifying implausible gestational age values on birth records, and combines these ideas by setting forth scenarios for identifying and then imputing missing and implausible gestational age values multiple times. Because missing and implausible gestational age values are not missing completely at random, using multiple imputations and, thus, incorporating both the existing relationships among the variables and the uncertainty added from the imputation, may lead to more valid inferences in some analytical studies than simply excluding birth records with inadequate data.

  4. Age, origin and significance of SKS splitting in SE Iberia: insights from mantle xenoliths from Neogene alkaline basalts

    NASA Astrophysics Data System (ADS)

    Konc, Z.; Garrido, C. J.; Tommasi, A.; Padron Navarta, J. A.; Hidas, K.; Bosch, D.; Marchesi, C.; Szabó, Cs.

    2012-04-01

    The volcanic activity in the SE Iberian Volcanic Province (SE IVP) is the surface expression of magmatism in a complex geodynamic setting during the Cenozoic development of a Mediterranean-type back-arc basin in the Alboran realm. The late stage of this geodynamical evolution was characterized by Neogene alkaline basalt volcanism erupted at 2-3 Ma in the Tallante and Los Perez (Murcia) volcanic centers. This volcanism entrained numerous mantle xenoliths that provide a recent snapshot of the structure of the lithospheric mantle beneath this region. Xenoliths are spinel (± plagioclase ± amphibole) lherzolite, and minor harzburgite and wehrlite showing porphyroclastic to fine- to medium-grained granoblastic textures. Mantle xenoliths display a marked axial [100] pattern olivine Crystal Preferred Orientation (CPO) characterized by a strong alignment of olivine [100] axes near or parallel to the peridotite lineation and a girdle distribution of [010] axes with a maximum normal to the peridotite foliation. This CPO is consistent with dominant activation of the high temperature [100]{0kl} slip systems of olivine formed under a deformation regime dominated by simple shear or combinations of simple shear and pure shear with a transtensional component. The age of this deformation event is constrained by syn-tectonice composite xenoliths formed by reactive percolation of Si-rich melt/fluids with the lithospheric mantle during middle Miocene subduction/delamination of the paleo-iberian margin beneath the SE IVP. In order to investigate whether SKS anystropy recently measured beneath this region can be accounted by the olivine CPO of the lithospheric mantle, we have computed the theoretical seismic anisotropy of mantle xenoliths from their olivine CPOs and modal compositions. The averaged seismic properties of SE-IVP mantle xenoliths are characterized by fast propagation of P-waves and polarization of fast S-waves parallel to the peridotite lineation. The computed highest S

  5. [Discussion about vaccines from animal origin at the Mexican National Academy of Medicine in the XIX century].

    PubMed

    Neri-Vela, Rolando

    2005-01-01

    This is a recount about the prevailing ideas in Mexico during the second half of the XIX century for introducing the use of vaccines of animal origin; thus, the thoughts of men like Agustín Andrade, Angel Iglesias y Domínguez, Lino Ramírez, Fernando Malanco and Luis E. Ruiz, who emphasized this work.

  6. The National Center for Community Education: On the Threshold of a New Age.

    ERIC Educational Resources Information Center

    Krajewski, Fran; Osowski, Val

    1997-01-01

    The Charles Stewart Mott Foundation has been involved in the community-school/community-education movement since the 1935 Flint Community Schools (Michigan) experiment led to fuller use of local school facilities for learning and recreation programs. The National Center for Community Education (NCCE) was established in the 1960s as a training…

  7. Literacy in Malta: The National Literacy Survey of Year 5 Pupils (Aged 9-10)

    ERIC Educational Resources Information Center

    Mifsud, Charles; Grech, Rowena; Hutchison, Dougal; Morrison, Jo

    2005-01-01

    The work reported here is based on the second Malta National Literacy Survey, carried out in March 2002. All Year 5 pupils in Malta were involved and their literacy attainment in both Maltese and English was tested. Two parallel multi-level analyses were carried out, one for Maltese, the other for English. The background variables were; gender,…

  8. School and Nation: Identity Politics and Educational Media in an Age of Diversity

    ERIC Educational Resources Information Center

    Carrier, Peter, Ed.

    2013-01-01

    At a time when the power of schools and both state and federal education authorities to guide young people's sense of belonging is being challenged by multilingualism, by the claims of supra- and subnational regions and minorities, by memories of national catastrophes and crimes, and by out-of-school educational media, this collection of essays…

  9. Suicide Attempts in Israel: Age by Gender Analysis of a National Emergency Departments Database

    ERIC Educational Resources Information Center

    Levinson, Daphna; Haklai, Ziona; Stein, Nechama; Gordon, Ethel-Sherry

    2006-01-01

    An analysis of all emergency department admissions in Israel classified as an attempted suicide in the years 1996-2002 was done to examine attempted suicide rates by age and gender with particular attention to adolescents and young adults. Gender differences in attempted suicide rates were significant only during adolescence and young adulthood,…

  10. The Hierarchical Factor Model of ADHD: Invariant across Age and National Groupings?

    ERIC Educational Resources Information Center

    Toplak, Maggie E.; Sorge, Geoff B.; Flora, David B.; Chen, Wai; Banaschewski, Tobias; Buitelaar, Jan; Ebstein, Richard; Eisenberg, Jacques; Franke, Barbara; Gill, Michael; Miranda, Ana; Oades, Robert D.; Roeyers, Herbert; Rothenberger, Aribert; Sergeant, Joseph; Sonuga-Barke, Edmund; Steinhausen, Hans-Christoph; Thompson, Margaret; Tannock, Rosemary; Asherson, Philip; Faraone, Stephen V.

    2012-01-01

    Objective: To examine the factor structure of attention-deficit/hyperactivity disorder (ADHD) in a clinical sample of 1,373 children and adolescents with ADHD and their 1,772 unselected siblings recruited from different countries across a large age range. Hierarchical and correlated factor analytic models were compared separately in the ADHD and…

  11. Cross-national comparison of disability in Latin American and Caribbean persons aged 75 and older.

    PubMed

    Reyes-Ortiz, Carlos A; Ostir, Glenn V; Pelaez, Martha; Ottenbacher, Kenneth J

    2006-01-01

    The objectives of this study were to compare rates of instrumental activity of daily living (IADL) and activity of daily living (ADL) difficulties and examine sociodemographic and health correlates of IADL and ADL difficulties. Data were extracted from the first interview of Health, Well-Being and Aging in Latin America and the Caribbean Study (abbreviated from Spanish name as: SABE = salud, bienestar y envejecimiento en America Latina y el Caribe). This analysis included 3225 subjects aged 75 and older living in seven capital cities during 1999-2000. Reporting either IADL or ADL difficulties were the outcomes. Bivariate and multiple logistic regression analyses were used to examine the associations between IADL or ADL difficulties and sociodemographics, and health characteristics. The highest prevalence of IADL difficulties was reported in Sao Paulo (33.8%) and the lowest in Montevideo (12.0%). The highest prevalence of ADL difficulties was reported in Santiago (34.7%) and the lowest in Bridgetown (16.9%). In a combined analysis across cities, increased age, fewer years of education, lower body mass index (BMI) (<20), and high number of medical conditions were independently significantly associated with IADL and ADL difficulties. In conclusion, about a third of persons aged 75 and older reported difficulty in at least one IADL or ADL. There was a wide variation on disability rates and correlates across cities. PMID:16126289

  12. 75 FR 54890 - National Institute on Aging; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-09

    ... Panel; Aminergic Function in Brain Aging and Alzheimer's Disease. Date: October 19, 2010. Time: 12 p.m... Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is... provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The...

  13. 78 FR 64963 - National Institute on Aging; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-30

    ... Notice is hereby given of a change in the meeting of the Behavior and Social Science of Aging Review... FR 55752. The meeting has been changed to December 10, 2013, 03:00 p.m. to 07:00 p.m. and December...

  14. Language, Literacy and Numeracy in National Training Packages: Case Studies in Aged Care and Hospitality.

    ERIC Educational Resources Information Center

    Haines, Christine; Brand, Jennie Bickmore

    The implementation and effectiveness of the inclusion of literacy and numeracy in industry training packages was examined in case studies of three programs in Western Australia. Two were certificate programs in cooking and food and beverage as specified in the hospitality training package, and the third was an aged care program based on the…

  15. Childhood Risk Factors for Lifetime Anorexia Nervosa by Age 30 Years in a National Birth Cohort

    ERIC Educational Resources Information Center

    Nicholls, Dasha E.; Viner, Russell M.

    2009-01-01

    Whether previously identified childhood risk factors for anorexia nervosa (AN) predict self-reported lifetime AN by age 30 is examined. The cohort confirmed four risk and two protective factors out of the 22 suggested risk factors. The study used data from the 1970 British Cohort Study.

  16. Age, sex, and racial differences in harsh physical punishment: results from a nationally representative United States sample.

    PubMed

    Taillieu, Tamara L; Afifi, Tracie O; Mota, Natalie; Keyes, Katherine M; Sareen, Jitender

    2014-12-01

    The purpose of this research was to examine age, sex, and racial differences in the prevalence of harsh physical punishment in childhood in a nationally representative sample of the United States. Data were from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) collected in 2004 and 2005 (n=34,653). Logistic regression analyses were conducted to examine age, sex, and racial differences in the prevalence of harsh physical punishment. Results suggest that the prevalence of harsh physical punishment has been decreasing among more recently born age groups; however, there appear to be sex and racial differences in this trend over time. The magnitude of the decrease appears to be stronger for males than for females. By race, the decrease in harsh physical punishment over time is only apparent among Whites; Black participants demonstrate little change over time, and harsh physical punishment seems to be increasing over time among Hispanics. Prevention and intervention efforts that educate about the links of physical punishment to negative outcomes and alternative non-physical discipline strategies may be particularly useful in reducing the prevalence of harsh physical punishment over time.

  17. The Development of Cognitive, Language, and Cultural Skills from Age 3 to 6: A Comparison between Children of Turkish Origin and Children of Native-Born German Parents and the Role of Immigrant Parents' Acculturation to the Receiving Society

    ERIC Educational Resources Information Center

    Becker, Birgit; Klein, Oliver; Biedinger, Nicole

    2013-01-01

    This article analyzes the longitudinal development of differences in academic skills between children of Turkish origin and children of native-born German parents from age 3 to 6 in Germany with a focus on the role of immigrant parents' acculturation to the receiving society. Growth curve models show that Turkish-origin children start with lower…

  18. Age and speciation of iodine in groundwater and mudstones of the Horonobe area, Hokkaido, Japan: Implications for the origin and migration of iodine during basin evolution

    NASA Astrophysics Data System (ADS)

    Togo, Yoko S.; Takahashi, Yoshio; Amano, Yuki; Matsuzaki, Hiroyuki; Suzuki, Yohey; Terada, Yasuko; Muramatsu, Yasuyuki; Ito, Kazumasa; Iwatsuki, Teruki

    2016-10-01

    This paper reports the concentration, speciation and isotope ratio (129I/127I) of iodine from both groundwater and host rocks in the Horonobe area, northern Hokkaido, Japan, to clarify the origin and migration of iodine in sedimentary rocks. Cretaceous to Quaternary sedimentary rocks deposited nearly horizontally in Tenpoku Basin and in the Horonobe area were uplifted above sea level during active tectonics to form folds and faults in the Quaternary. Samples were collected from the Pliocene Koetoi and late Miocene Wakkanai formations (Fms), which include diatomaceous and siliceous mudstones. The iodine concentration in groundwater, up to 270 μmol/L, is significantly higher than that of seawater, with the iodine enrichment factor relative to seawater reaching 800-1500. The iodine concentration in the rocks decreases from the Koetoi to Wakkanai Fms, suggesting that iodine was released into the water from the rocks of deeper formations. The iodine concentration in the rocks is sufficiently high for forming iodine-rich groundwater as found in this area. X-ray absorption near edge structure (XANES) analysis shows that iodine exists as organic iodine and iodide (I-) in host rocks, whereas it exists mainly as I- in groundwater. The isotope ratio is nearly constant for iodine in the groundwater, at [0.11-0.23] × 10-12, and it is higher for iodine in rocks, at [0.29-1.1] × 10-12, giving iodine ages of 42-60 Ma and 7-38 Ma, respectively. Some iodine in groundwater must have originated from Paleogene and even late Cretaceous Fms, which are also considered as possible sources of oil and gas, in view of the old iodine ages of the groundwater. The iodine ages of the rocks are older than the depositional ages, implying that the rocks adsorbed some iodine from groundwater, which was sourced from greater depths. The iodine concentration in groundwater decreases with decreasing chlorine concentration due to mixing of iodine-rich connate water and meteoric water. A likely scenario

  19. [Violence in old age: the issue addressed in indexed national journals].

    PubMed

    de Castro, Anúbes Pereira; Guilam, Maria Cristina Rodrigues; Sousa, Eduardo Sérgio Soares; Marcondes, Willer Baumgarten

    2013-05-01

    One of the consequences of increased life expectancy is the increase in the elderly population in many countries, including Brazil. Considering the vulnerability of this age group and the increasing prevalence of violence against the elderly, there is a pressing need for research and control interventions to minimize the phenomenon. This exploratory and descriptive article conducts an analysis into this topic in indexed Brazilian studies in SciELO, with special emphasis on the last five years. The themes were categorized into: Social construction and conceptualizations, 37.5%; Elderly Care and Protection Policies, 43.75%; and Typology of violence against the elderly, 18.75%. The results show that the Policy of protection of the elderly permeates the majority of discussions about violence in old age and the focus of the researchers' attention is on domestic violence, which needs to be broadened in field research.

  20. Parental Age and Risk of Autism Spectrum Disorders in a Finnish National Birth Cohort

    ERIC Educational Resources Information Center

    Lampi, Katja M.; Hinkka-Yli-Salomäki, Susanna; Lehti, Venla; Helenius, Hans; Gissler, Mika; Brown, Alan S.; Sourander, Andre

    2013-01-01

    Aim of the study was to examine the associations between parental age and autism spectrum disorders (ASD). Data were based on the FIPS-A (Finnish Prenatal Study of Autism and Autism Spectrum Disorders), a case-control study with a total of 4,713 cases with childhood autism (n = 1,132), Asperger's syndrome (n = 1,785) or other pervasive…

  1. Saint-Gaudens National Historic Site: Home of a Gilded Age Icon. Teaching with Historic Places.

    ERIC Educational Resources Information Center

    Percoco, James A.

    Augustus Saint-Gaudens (1848-1907) was a renowned 19th-century U.S. sculptor whose artistic training and talent ensured his place in Gilded Age society. In 1885, he was drawn to Cornish, New Hampshire, to find a place where he could model his latest commission, a statue of Abraham Lincoln. He and his wife established a summer home and studio in an…

  2. Early adulthood: an overlooked age group in national sodium reduction initiatives in South Korea

    PubMed Central

    Park, Sohyun; Lee, Jounghee; Kwon, Kwang-Il; Kim, Jong-Wook; Byun, Jae-Eon; Kang, Baeg-Won; Choi, Bo Youl

    2014-01-01

    BACKGROUND/OBJECTIVES South Korean's sodium consumption level is more than twice the upper limit level suggested by the WHO. Steep increases in the prevalence of hypertension and cardiovascular disease in Korea necessitate more effective sodium reduction programs. This study was conducted in order to compare sodium intake-related eating behaviors and key psychosocial factors according to age group and gender. SUBJECTS/METHODS Using an online survey, a total of 1,564 adults (20-59 years old) considered to be geographically representative of South Korea were recruited and surveyed. The major outcomes were perceived behaviors, knowledge, intentions, and self-efficacy related to sodium intake. RESULTS The results show that perceived behavior and level of self-efficacy related to low sodium consumption differed by age and gender. Female participants showed better behavior and intention towards low sodium intake than male counterparts. Young participants in their 20s showed the lowest intention to change their current sodium intake as well as lowest self-efficacy measures. CONCLUSIONS Future sodium reduction interventions should be developed with tailored messages targeting different age and gender groups. Specifically, interventions can be planned and implemented at the college level or for workers in their early career to increase their intention and self-efficacy as a means of preventing future health complications associated with high sodium intake. PMID:25489413

  3. Visibility and the just allocation of health care: a study of age-rationing in the British National Health Service.

    PubMed

    Baker, R

    1993-11-01

    The British National Health Service (BNHS) was founded, to quote Minister of Health Aneurin Bevan, to 'universalize the best'. Over time, however, financial constraints forced the BNHS to turn to incrementalist budgeting, to rationalize care and to ask its practitioners to act as gatekeepers. Seeking a way to ration scarce tertiary care resources, BNHS gatekeepers began to use chronological age as a rationing criterion. Age-rationing became the 'done thing' without explicit policy directives and in a manner largely invisible to patients, to Parliament, and to the public. The invisibility of the practice, however, violates the publicity principle that John Rawls and other philosophers believe essential to fairness. BNHS invisible age-rationing practices are thus a test case of the principle that fairness presupposes publicity; they raise the question: is it possible to preserve equitability in a system that uses non-public criteria to allocate scarce resources? To seek an answer, published data on access to end-stage renal disease (ESRD) treatment in Britain and the European Community (EC) are analysed. Among the findings are: that BNHS age-rationing acts as an excuse for denying care to those most likely to need ESRD treatment; and is, moreover, arbitrary and inequitable. It is further argued that no age-rationing policy can sustain visibility, and that, if the BNHS is to be fair to its patients, it must reform its present age-rationing practices, replacing them by a publicly visible, outcome-based rationing policy that rations either in terms of QALYs or triage categories.

  4. Association of Insurance Status and Age With Cervical Cancer Stage at Diagnosis: National Cancer Database, 2000–2007

    PubMed Central

    Cokkinides, Vilma; Virgo, Katherine S.; Bandi, Priti; Saslow, Debbie; Ward, Elizabeth M.

    2012-01-01

    Objectives. We examined the relationship of age at diagnosis and insurance status with stage among cervical cancer patients aged 21 to 85 years. Methods. We selected data on women (n = 69 739) diagnosed with invasive cervical cancer between 2000 and 2007 from the National Cancer Database. We evaluated the association between late stage (stage III/IV) and both insurance and age, with adjustment for race/ethnicity and other sociodemographic and clinical factors. We used multivariable log binomial models to estimate risk ratios (RRs) and 95% confidence intervals (CIs). Results. The proportion of late-stage disease increased with age: from 16.53% (21–34 years) to 42.44% (≥ 70 years). The adjusted relative risk of advanced-stage disease among women aged 50 years and older was 2.2 to 2.5 times that of patients aged 21 to 34 years. Uninsured (RR = 1.44; 95% CI = 1.40, 1.49), Medicaid (RR = 1.37, 95% CI = 1.34, 1.41), younger Medicare (RR = 1.12, 95% CI = 1.06, 1.19), and older Medicare (RR = 1.20, 95% CI = 1.15, 1.26) patients had a higher risk of late-stage disease than did privately insured patients. Conclusions. Screening should be encouraged for women at high risk for advanced-stage disease. PMID:22742058

  5. Affective Norms for 4900 Polish Words Reload (ANPW_R): Assessments for Valence, Arousal, Dominance, Origin, Significance, Concreteness, Imageability and, Age of Acquisition

    PubMed Central

    Imbir, Kamil K.

    2016-01-01

    In studies that combine understanding of emotions and language, there is growing demand for good-quality experimental materials. To meet this expectation, a large number of 4905 Polish words was assessed by 400 participants in order to provide a well-established research method for everyone interested in emotional word processing. The Affective Norms for Polish Words Reloaded (ANPW_R) is designed as an extension to the previously introduced the ANPW dataset and provides assessments for eight different affective and psycholinguistic measures of Valence, Arousal, Dominance, Origin, Significance, Concreteness, Imageability, and subjective Age of Acquisition. The ANPW_R is now the largest available dataset of affective words for Polish, including affective scores that have not been measured in any other dataset (concreteness and age of acquisition scales). Additionally, the ANPW_R allows for testing hypotheses concerning dual-mind models of emotion and activation (origin and subjective significance scales). Participants in the current study assessed all 4905 words in the list within 1 week, at their own pace in home sessions, using eight different Self-assessment Manikin (SAM) scales. Each measured dimension was evaluated by 25 women and 25 men. The ANPW_R norms appeared to be reliable in split-half estimation and congruent with previous normative studies in Polish. The quadratic relation between valence and arousal was found to be in line with previous findings. In addition, nine other relations appeared to be better described by quadratic instead of linear function. The ANPW_R provides well-established research materials for use in psycholinguistic and affective studies in Polish-speaking samples. PMID:27486423

  6. Affective Norms for 4900 Polish Words Reload (ANPW_R): Assessments for Valence, Arousal, Dominance, Origin, Significance, Concreteness, Imageability and, Age of Acquisition.

    PubMed

    Imbir, Kamil K

    2016-01-01

    In studies that combine understanding of emotions and language, there is growing demand for good-quality experimental materials. To meet this expectation, a large number of 4905 Polish words was assessed by 400 participants in order to provide a well-established research method for everyone interested in emotional word processing. The Affective Norms for Polish Words Reloaded (ANPW_R) is designed as an extension to the previously introduced the ANPW dataset and provides assessments for eight different affective and psycholinguistic measures of Valence, Arousal, Dominance, Origin, Significance, Concreteness, Imageability, and subjective Age of Acquisition. The ANPW_R is now the largest available dataset of affective words for Polish, including affective scores that have not been measured in any other dataset (concreteness and age of acquisition scales). Additionally, the ANPW_R allows for testing hypotheses concerning dual-mind models of emotion and activation (origin and subjective significance scales). Participants in the current study assessed all 4905 words in the list within 1 week, at their own pace in home sessions, using eight different Self-assessment Manikin (SAM) scales. Each measured dimension was evaluated by 25 women and 25 men. The ANPW_R norms appeared to be reliable in split-half estimation and congruent with previous normative studies in Polish. The quadratic relation between valence and arousal was found to be in line with previous findings. In addition, nine other relations appeared to be better described by quadratic instead of linear function. The ANPW_R provides well-established research materials for use in psycholinguistic and affective studies in Polish-speaking samples. PMID:27486423

  7. Origins, Chronology, and Current Status of the National Research Center for Career and Technical Education: 1963-2012

    ERIC Educational Resources Information Center

    Lewis, Morgan V.; Stone, James R., III

    2013-01-01

    The National Research Center for Career and Technical Education (NRCCTE) had a unique status among federally funded research and development center in education. Its funding was authorized by the federal legislation for career and technical and administered by the Office of Vocational and Adult Education, not the Institute for Education Sciences.…

  8. "A Miniature League of Nations": Inquiry into the Social Origins of the International School, 1924-1930

    ERIC Educational Resources Information Center

    Dugonjic, Leonora

    2014-01-01

    Today, the International School of Geneva is known as the world's oldest and largest private international school, having opened in 1924 under the name "International School". Many schools have attempted to foster an international environment in a general sense; this school is the first to claim an "inter-national"…

  9. Petrography, age, and paleomagnetism of basaltic lava flows in coreholes at Test Area North (TAN), Idaho National Engineering Laboratory

    SciTech Connect

    Lanphere, M.A.; Champion, D.E.; Kuntz, M.A.

    1994-12-31

    The petrography, age, and paleomagnetism were determined on basalt from 21 lava flows comprising about 1,700 feet of core from two coreholes (TAN CH No. 1 and TAN CH No. 2) in the Test Area North (TAN) area of the Idaho National Engineering Laboratory (INEL). Paleomagnetic studies were made on two additional cores from shallow coreholes in the TAN area. K-Ar ages and paleomagnetism also were determined on nearby surface outcrops of Circular Butte. Paleomagnetic measurements were made on 416 samples from four coreholes and on a single site in surface lava flows of Circular Butte. K-Ar ages were measured on 9 basalt samples from TAN CH No. 1 and TAN CH No. 2 and one sample from Circular Butte. K-Ar ages ranged from 1.044 Ma to 2.56 Ma. All of the samples have reversed magnetic polarity and were erupted during the Matuyama Reversed Polarity Epoch. The purpose of investigations was to develop a three-dimensional stratigraphic framework for geologic and hydrologic studies including potential volcanic hazards to facilities at the INEL and movement of radionuclides in the Snake River Plain aquifer.

  10. Preliminary insight into the age and origin of the Labeobarbus fish species flock from Lake Tana (Ethiopia) using the mtDNA cytochrome b gene.

    PubMed

    de Graaf, Martin; Megens, Hendrik-Jan; Samallo, Johannis; Sibbing, Ferdinand

    2010-02-01

    The high diversity of Cyprinid fish in Ethiopia's Lake Tana appears to be an example of ecological differentiation and assortative mating leading to rapid sympatric speciation. Lake Tana's Labeobarbus species flock consists of 15 morphological and ecological distinct species. This is the first attempt to determine the age and origin and inter-species relationships of Lake Tana's Labeobarbus species using the mtDNA cytochrome b gene. Analysis of cytchrome b sequences shows that Lake Tana's species flock appears to be young but the present dataset did not unequivocally support monophyly of Lake Tana's species. Additional markers are needed to determine whether Lake Tana's labeobarbs originated from a single or multiple incursion(s) of ancestral L. intermedius in the Lake Tana drainage basin, or the disruption of an ancient continuous riverine population by the emergence of the Tissisat waterfalls. Adaptive radiation and speciation within Lake Tana's Labeobarbus species flock may have occurred in the last 10,000-25,000years, following the desiccation of Lake Tana around 17,000years ago, at the same time as Lake Victoria, however, obtaining more data using other (nuclear) markers is urgently required. PMID:19878730

  11. Preliminary insight into the age and origin of the Labeobarbus fish species flock from Lake Tana (Ethiopia) using the mtDNA cytochrome b gene.

    PubMed

    de Graaf, Martin; Megens, Hendrik-Jan; Samallo, Johannis; Sibbing, Ferdinand

    2010-02-01

    The high diversity of Cyprinid fish in Ethiopia's Lake Tana appears to be an example of ecological differentiation and assortative mating leading to rapid sympatric speciation. Lake Tana's Labeobarbus species flock consists of 15 morphological and ecological distinct species. This is the first attempt to determine the age and origin and inter-species relationships of Lake Tana's Labeobarbus species using the mtDNA cytochrome b gene. Analysis of cytchrome b sequences shows that Lake Tana's species flock appears to be young but the present dataset did not unequivocally support monophyly of Lake Tana's species. Additional markers are needed to determine whether Lake Tana's labeobarbs originated from a single or multiple incursion(s) of ancestral L. intermedius in the Lake Tana drainage basin, or the disruption of an ancient continuous riverine population by the emergence of the Tissisat waterfalls. Adaptive radiation and speciation within Lake Tana's Labeobarbus species flock may have occurred in the last 10,000-25,000years, following the desiccation of Lake Tana around 17,000years ago, at the same time as Lake Victoria, however, obtaining more data using other (nuclear) markers is urgently required.

  12. HIV knowledge and attitudes among providers in aging: results from a national survey.

    PubMed

    Hughes, Anne K

    2011-09-01

    Within 5 years, half the U.S. HIV-infected population will be over age 50, and providers caring for older adults must deal with this reality. This study assessed attitudes toward people with HIV/AIDS and knowledge of HIV/AIDS among physicians with a geriatrics specialty, and nurses and social workers who specialize in gerontology. A survey mailed in 2008 to a random sample of U.S. providers yielded a 60% response rate. Main outcome measures included: Knowledge of HIV/AIDS, attitudes toward people with HIV/AIDS, and knowledge of issues related to HIV in older adults. General knowledge of HIV/AIDS was good with scores of 89%, 84%, and 81% for physicians, nurses, and social workers, respectively; groups differed significantly (F(2, 483)=18.626, p<0.0005). Attitudes were positive, with a significant main effect of profession on the attitude subscales (F(4, 952)=6.84, p<0.0005). Eighty-three percent of the sample were unaware that dementia due to HIV may be reversible; no significant differences by profession (χ(2)=4.50, p=0.105). The sample had difficulty ranking the four most common risk factors for HIV infection in older adults, with no significant differences among the professions (F(2, 483)=1.22, p=0.296). Only 6% of the sample correctly ranked all four risk factors. Estimates of the percent of U.S. AIDS cases in people over age 50 varied widely; few answered correctly, with no significant differences by professional group (F(2,319)=2.82, p=0.06). These findings highlight the need for further education among providers who specialize in aging.

  13. Age, fertility and reproductive behavior in cuban crocodiles, Crocodylus rhombifer, at the Smithsonian's National Zoological Park.

    PubMed

    Augustine, Lauren; Watkins, Barbara

    2015-01-01

    The Smithsonian's National Zoological Park (NZP) has a long history with Cuban crocodiles, Crocodylus rhombifer, beginning in 1900's when the first animals arrived at the NZP. Today, the Zoo has two breeding groups of C. rhombifer and has observed and analyzed reproductive behavior and fertility rates over the last three years. Fertility rates were determined initially by observing the formation of an opaque band that forms on the shell of a fertile egg, called banding. The fertility rates by banding were later compared to the observation made after opening the eggs to verify fertility. In addition to tracking fertility, nesting and agonistic behavior were also observed. Several notable observations were documented over the same period. These included a male predating a nesting female's eggs, increased aggression between two females housed together, the continued development of a partially banded egg, and the discovery of 19 additional egg shells post oviposition by both females in the enclosure. Here we discuss the nest phenology, fertility and behavior of the five exhibited C. rhombifer at the Smithsonian's National Zoological Park over a 3-year period. Zoo Biol. 34:278-284, 2015. © 2015 Wiley Periodicals Inc.

  14. Age, fertility and reproductive behavior in cuban crocodiles, Crocodylus rhombifer, at the Smithsonian's National Zoological Park.

    PubMed

    Augustine, Lauren; Watkins, Barbara

    2015-01-01

    The Smithsonian's National Zoological Park (NZP) has a long history with Cuban crocodiles, Crocodylus rhombifer, beginning in 1900's when the first animals arrived at the NZP. Today, the Zoo has two breeding groups of C. rhombifer and has observed and analyzed reproductive behavior and fertility rates over the last three years. Fertility rates were determined initially by observing the formation of an opaque band that forms on the shell of a fertile egg, called banding. The fertility rates by banding were later compared to the observation made after opening the eggs to verify fertility. In addition to tracking fertility, nesting and agonistic behavior were also observed. Several notable observations were documented over the same period. These included a male predating a nesting female's eggs, increased aggression between two females housed together, the continued development of a partially banded egg, and the discovery of 19 additional egg shells post oviposition by both females in the enclosure. Here we discuss the nest phenology, fertility and behavior of the five exhibited C. rhombifer at the Smithsonian's National Zoological Park over a 3-year period. Zoo Biol. 34:278-284, 2015. © 2015 Wiley Periodicals Inc. PMID:25716550

  15. Aspen Ecology in Rocky Mountain National Park: Age Distribution, Genetics, and the Effects of Elk Herbivory

    SciTech Connect

    Tuskan, Gerald A; Yin, Tongming

    2008-10-01

    Lack of aspen (Populus tremuloides) recruitment and canopy replacement of aspen stands that grow on the edges of grasslands on the low-elevation elk (Cervus elaphus) winter range of Rocky Mountain National Park (RMNP) in Colorado has been a cause of concern for more than 70 years (Packard, 1942; Olmsted, 1979; Stevens, 1980; Hess, 1993; R.J. Monello, T.L. Johnson, and R.G. Wright, Rocky Mountain National Park, 2006, written commun.). These aspen stands are a significant resource since they are located close to the park's road system and thus are highly visible to park visitors. Aspen communities are integral to the ecological structure of montane and subalpine landscapes because they contain high native species richness of plants, birds, and butterflies (Chong and others, 2001; Simonson and others, 2001; Chong and Stohlgren, 2007). These low-elevation, winter range stands also represent a unique component of the park's plant community diversity since most (more than 95 percent) of the park's aspen stands grow in coniferous forest, often on sheltered slopes and at higher elevations, while these winter range stands are situated on the low-elevation ecotone between the winter range grasslands and some of the park's drier coniferous forests.

  16. Origin and age of zircon-bearing chromitite layers from the Finero phlogopite peridotite (Ivrea-Verbano Zone, Western Alps) and geodynamic consequences

    NASA Astrophysics Data System (ADS)

    Zanetti, Alberto; Giovanardi, Tommaso; Langone, Antonio; Tiepolo, Massimo; Wu, Fu-Yuan; Dallai, Luigi; Mazzucchelli, Maurizio

    2016-10-01

    An investigation has been performed on three chromitite layers segregated in dunite bodies of the Phlogopite Peridotite mantle unit in the Finero complex (FPP, Ivrea-Verbano Zone, Southern Alps) aimed at providing new constraints to their origin and evolution. Field relationships, the sub-chondritic Hf isotopic composition of the zircons (εHf(188) as low as - 5.4), the heavy O isotopic composition of zircons and pyroxenes (δ18O up to 6.9‰), the strict similarity of the trace element composition between the clinopyroxenes and amphiboles from the chromitites and those from the phlogopite harzburgites and pyroxenites forming the typical FPP association, as well as the REE composition of zircons, which approaches equilibrium with the associate clinopyroxene, suggest that the studied chromitites were segregated from melts, highly contaminated from continental crust, during the pervasive cycle of metasomatism recorded by the FPP. An LA-ICP-HRMS survey of chromitite zircon grains has provided Early Jurassic U-Pb ages mostly between 199 ± 3 Ma and 178 ± 2 Ma, with a pronounced peak at 187 Ma. Relevant exceptions are inherited domains of two grains giving Triassic ages of 242 ± 7 Ma and 229 ± 7 Ma, and a third homogeneous zircon giving 208 ± 3 Ma. Our geochronological data and those reported in the literature show that the FPP chromitites have zircon populations with different internal CL textures, but the same sub-chondritic Hf isotopic composition, which define an overall U-Pb age span from ~ 290 Ma to 180. The segregation of the chromitite layers and the main pervasive metasomatism likely occurred in the Early Permian (in a post-collisional, transtensional setting) or before (possibly, in a subduction-related setting). The rejuvenation of the zircon ages was accompanied by a progressive disappearance of the internal zoning, interpreted as the result of a prolonged residence at mantle depths with progressive re-equilibration of the U-Pb system due to thermal

  17. Measuring Cognition: The Chicago Cognitive Function Measure in the National Social Life, Health and Aging Project, Wave 2

    PubMed Central

    Sunkara, Priya D.; Kotwal, Ashwin; Kern, David W.; Henning, Sara L.; McClintock, Martha K.; Schumm, Philip; Waite, Linda J.; Dale, William

    2014-01-01

    Objectives. To describe the development of a multidimensional test of cognition for the National Social life, Health and Aging Project (NSHAP), the Chicago Cognitive Function Measure (CCFM). Method. CCFM development included 3 steps: (a) A pilot test of the Montreal Cognitive Assessment (MoCA) to create a standard protocol, choose specific items, reorder items, and improve clarity; (b) integration into a CAPI-based format; and (c) evaluation of the performance of the CCFM in the field. The CCFM was subsequently incorporated into NSHAP, Wave 2 (n = 3,377). Results. The pre-test (n = 120) mean age was 71.35 (SD 8.40); 53% were female, 69% white, and 70% with college or greater education. The MoCA took an average of 15.6min; the time for the CCFM was 12.0min. CCFM scores (0–20) can be used as a continuous outcome or to adjust for cognition in a multivariable analysis. CCFM scores were highly correlated with MoCA scores (r = .973). Modeling projects MoCA scores from CCFM scores using the equation: MoCA = (1.14 × CCFM) + 6.83. In Wave 2, the overall weighted mean CCFM score was 13.9 (SE 0.13). Discussion. A survey-based adaptation of the MoCA was successfully integrated into a nationally representative sample of older adults, NSHAP Wave 2. PMID:25360018

  18. A Nation of Immigrants: Assimilation and Economic Outcomes in the Age of Mass Migration

    PubMed Central

    Abramitzky, Ran; Boustan, Leah Platt; Eriksson, Katherine

    2015-01-01

    During the Age of Mass Migration (1850–1913), the United States maintained an open border, absorbing 30 million European immigrants. Prior cross-sectional work finds that immigrants initially held lower-paid occupations than natives but converged over time. In newly assembled panel data, we show that, in fact, the average immigrant did not face a substantial occupation-based earnings penalty upon first arrival and experienced occupational advancement at the same rate as natives. Cross-sectional patterns are driven by biases from declining arrival cohort skill level and departures of negatively selected return migrants. We show that assimilation patterns vary substantially across sending countries and persist in the second generation. PMID:26609186

  19. Age of ground water in basalt aquifers near Spring Creek National Fish Hatchery, Skamania County, Washington

    USGS Publications Warehouse

    Hinkle, Stephen R.

    1996-01-01

    A comparison of CFC data with both adjusted and unadjusted 14C data suggests that water discharging at the hatchery springs contains a mixture of modem and old water, where old water is defined as water recharged prior to 1944. The CFC data support a component of modem water, whereas the 14C data suggest a component of old water. Similar results were obtained from a comparison of CFC data with adjusted and unadjusted 14C data for water collected from Well 3. Well 3 is north of the hatchery springs, on a flow path that appears to be parallel to and similar in length to the flow path leading to the hatchery springs. Water from the Hatchery Well, however, may be devoid of modem water and appears to have an overall age on the order of thousands of years.

  20. Strategic priorities for increasing physical activity among adults age 50 and older: the national blueprint consensus conference summary report.

    PubMed

    Sheppard, Lisa; Senior, Jane; Park, Chae Hee; Mockenhaupt, Robin; Bazzarre, Terry; Chodzko-Zajko, Wojtek

    2003-12-01

    On May 1, 2001, a coalition of national organizations released a major planning document designed to develop a national strategy for the promotion of physically active lifestyles among the mid-life and older adult population. The National Blueprint: Increasing Physical Activity Among Adults Age 50 and Older was developed with input from 46 organizations with expertise in health, medicine, social and behavioral sciences, epidemiology, gerontology/geriatrics, clinical science, public policy, marketing, medical systems, community organization, and environmental issues. The Blueprint notes that, despite a wealth of evidence about the benefits of physical activity for mid-life and older persons, there has been little success in convincing age 50+ Americans to adopt physically active lifestyles. The Blueprint identifies barriers in the areas of research, home and community programs, medical systems, public policy and advocacy, and marketing and communications. In addition to identifying barriers, the Blueprint proposes a number of concrete strategies that could be employed in order to overcome the barriers to physical activity in society at large. This report summarizes the outcome of the National Blueprint Consensus Conference that was held in October 2002. In this conference, representatives of more than 50 national organizations convened in Washington, D.C. with the goal of identifying high priority and high feasibility strategies which would advance the National Blueprint and which could be initiated within the next 12 to 24 months. Participants in the consensus conference were assigned to one of five breakout groups: home and community, marketing, medical systems, public policy, and research. Each breakout group was charged with identifying the three highest priority strategies within their area for effectively increasing physical activity levels in the mid-life and older adult population. In addition to the 15 strategies identified by the breakout groups, three

  1. Mercury concentrations in salmonids from western U.S. National Parks and relationships with age and macrophage aggregates.

    PubMed

    Schwindt, Adam R; Fournie, John W; Landers, Dixon H; Schreck, Carl B; Kent, Michael L

    2008-02-15

    Mercury accumulation in aquatic foodwebs and its effects on aquatic biota are of growing concern both for the health of the fish and the piscivores that prey upon them. This is of particular concern for western U.S. National Parks because it is known that mountainous and Arctic areas are sinks for some contaminants. The Western Airborne Contaminants Assessment Project seeks, in part, to ascertain mercury concentrations and evaluate effects of contaminants on biota in 14 lakes from 8 National Parks or Preserves. In this paper we report that mercury has accumulated to concentrations in troutthat may negatively impact some piscivorous wildlife, indicating potential terrestrial ecosystem effects. Additionally, we show that mercury concentrations increase with age in 4 species of trout, providing evidence of bioaccumulation. Finally, we demonstrate that mercury is associated with tissue damage in the kidney and spleen, as indicated by increases in macrophage aggregates. This finding suggests that mercury, and possibly other contaminants, are Macrophage aggregates suggests that mercury, a negatively affecting the trout that inhabit these remote and protected ecosystems. Our results indicate that mercury is indeed a concern for the U.S. National Parks, from an organismic and potentially an ecosystem perspective.

  2. Mercury concentrations in salmonids from western U.S. National Parks and relationships with age and macrophage aggregates

    USGS Publications Warehouse

    Schwindt, A.R.; Fournie, J.W.; Landers, D.H.; Schreck, C.B.; Kent, M.L.

    2008-01-01

    Mercury accumulation in aquatic foodwebs and its effects on aquatic biota are of growing concern both for the health of the fish and the piscivores that prey upon them. This is of particular concern for western U.S. National Parks because it is known that mountainous and Arctic areas are sinks for some contaminants. The Western Airborne Contaminants Assessment Project seeks, in part, to ascertain mercury concentrations and evaluate effects of contaminants on biota in 14 lakes from 8 National Parks or Preserves. In this paper we report that mercury has accumulated to concentrations in trout that may negatively impact some piscivorous wildlife, indicating potential terrestrial ecosystem effects. Additionally, we show that mercury concentrations increase with age in 4 species of trout, providing evidence of bioaccumulation. Finally, we demonstrate that mercury is associated with tissue damage in the kidney and spleen, as indicated by increases in macrophage aggregates. This finding suggests that mercury, and possibly other contaminants, are negatively affecting the trout that inhabit these remote and protected ecosystems. Our results indicate that mercury is indeed a concern for the U.S. National Parks, from an organismic and potentially an ecosystem perspective. ?? 2008 American Chemical Society.

  3. Ear Infection and Its Associated Risk Factors in First Nations and Rural School-Aged Canadian Children

    PubMed Central

    Karunanayake, Chandima P.; Albritton, William; Rennie, Donna C.; Lawson, Joshua A.; McCallum, Laura; Gardipy, P. Jenny; Seeseequasis, Jeremy; Naytowhow, Arnold; Hagel, Louise; McMullin, Kathleen; Ramsden, Vivian; Abonyi, Sylvia; Episkenew, Jo-Ann; Dosman, James A.; Pahwa, Punam; Project Research Team, The First Nations Lung Health; Study Team, The Saskatchewan Rural Health

    2016-01-01

    Background. Ear infections in children are a major health problem and may be associated with hearing impairment and delayed language development. Objective. To determine the prevalence and the associated risk factors of ear infections in children 6–17 years old residing on two reserves and rural areas in the province of Saskatchewan. Methodology. Data were provided from two rural cross-sectional children studies. Outcome variable of interest was presence/absence of an ear infection. Logistic regression analysis was conducted to examine the relationship between ear infection and the other covariates. Results. The prevalence of ear infection was 57.8% for rural Caucasian children and 43.6% for First Nations children living on-reserve. First Nations children had a lower risk of ear infection. Ear infection prevalence was positively associated with younger age; first born in the family; self-reported physician-diagnosed tonsillitis; self-reported physician-diagnosed asthma; and any respiratory related allergy. Protective effect of breastfeeding longer than three months was observed on the prevalence of ear infection. Conclusions. While ear infection is a prevalent condition of childhood, First Nations children were less likely to have a history of ear infections when compared to their rural Caucasian counterparts. PMID:26977160

  4. Tetanus Immunity among Women Aged 15 to 39 Years in Cambodia: a National Population-Based Serosurvey, 2012.

    PubMed

    Scobie, Heather M; Mao, Bunsoth; Buth, Sokhal; Wannemuehler, Kathleen A; Sørensen, Charlotte; Kannarath, Chheng; Jenks, M Harley; Moss, Delynn M; Priest, Jeffrey W; Soeung, Sann Chan; Deming, Michael S; Lammie, Patrick J; Gregory, Christopher J

    2016-07-01

    To monitor progress toward maternal and neonatal tetanus elimination (MNTE) in Cambodia, we conducted a nationwide serosurvey of tetanus immunity in 2012. Multistage cluster sampling was used to select 2,154 women aged 15 to 39 years. Tetanus toxoid antibodies in serum samples were measured by gold-standard double-antigen enzyme-linked immunosorbent assay (DAE) and a novel multiplex bead assay (MBA). Antibody concentrations of ≥0.01 IU/ml by DAE or the equivalent for MBA were considered seroprotective. Estimated tetanus seroprotection was 88% (95% confidence interval [CI], 86 to 89%); 64% (95% CI, 61 to 67%) of women had antibody levels of ≥1.0 IU/ml. Seroprotection was significantly lower (P < 0.001) among women aged 15 to 19 years (63%) and 20 to 24 years (87%) than among those aged ≥25 years (96%), among nulliparous women than among parous women (71 versus 97%), and among those living in the western region than among those living in other regions (82 versus 89%). The MBA showed high sensitivity (99% [95% CI, 98 to 99%]) and specificity (92% [95% CI, 88 to 95%]) compared with DAE. Findings were compatible with MNTE in Cambodia (≥80% protection). Tetanus immunity gaps should be addressed through strengthened routine immunization and targeted vaccination campaigns. Incorporating tetanus testing in national serosurveys using MBAs, which can measure immunity to multiple pathogens simultaneously, may be beneficial for monitoring MNTE. PMID:27053629

  5. Predictors of health practices within age-sex groups: National Survey of Personal Health Practices and Consequences, 1979.

    PubMed Central

    Rakowski, W

    1988-01-01

    Health promotion-disease prevention programs share with health behavior research the common objective of identifying population subgroups toward whom services can be targeted. For this report, six age-sex groups were examined to determine similarities and differences in the predictors of eight health practice indices. Data were from the 1979 National Survey of Personal Health Practices and Consequences. Results showed very little similarity of predictors across the three age cohorts (20-34, 35-49, 50-64), between men and women, and among the six age-sex groups. No predictor achieved significance consistently for several health practices in any of the six groups, although years of education made the best showing. The lack of overlap among predictors helps to explain why health promotion messages and recruitment strategies may not appeal to as diverse an audience as initially intended. Possible explanations for the absence of similar predictors include differences in the nature of the various practices themselves, absence of data on intentions behind a person's behavior, and the "over-determined" character of an individual person's behavior. PMID:3136496

  6. Geochemical and isotopic constraints on the age and origin of the Nidar Ophiolitic Complex, Ladakh, India: Implications for the Neo-Tethyan subduction along the Indus suture zone

    NASA Astrophysics Data System (ADS)

    Ahmad, T.; Tanaka, T.; Sachan, H. K.; Asahara, Y.; Islam, R.; Khanna, P. P.

    2008-04-01

    .P., 2001. Early Cretaceous radiolarians from the Indus suture zone, Ladakh, northern India. In: News of Osaka Micropaleontologists (NOM), Spec. Vol., 12, 257-270.) and cooling ages of 110-130 Ma based on 39Ar/ 40Ar for Nidar-Spontang ophiolitic rocks (Mahéo, G., Berttrand, H., Guillot, S., Villa, I. M., Keller, F., Capiez, P., 2004. The South Ladakh Ophiolites (NW Himalaya, India): an intra-oceanic tholeiitic arc origin with implications for the closure of the Neo-Tethys. Chem. Geol., 203, 273-303.). As these gabbroic and volcanic rocks are interpreted to be arc related, the new Sm-Nd age data may indicate that intra-ocean subduction in the Neo-Tethyan ocean may have started much before ˜ 140 ± 32 Ma as this date is interpreted as the age of crystallization of the arc magma. Present and published age data on the arc magmatic rocks from the Indus suture zone may collectively indicate episodic magmatism with increasing maturity of the arc from more basic (during ~ 140 ± 32 Ma) when the arc was immature through intermediate (andesitic/granodioritic) at ~ 100 Ma to more felsic (rhyolitic/dioritic) magmatism at ~ 50-45 Ma, when the Indian and the Asian plates collided.

  7. A multi-tracer approach for assessing the origin, apparent age and recharge mechanism of shallow groundwater in the Lake Nyos catchment, Northwest, Cameroon

    NASA Astrophysics Data System (ADS)

    Kamtchueng, Brice Tchakam; Fantong, Wilson Yetoh; Wirmvem, Mengnjo Jude; Tiodjio, Rosine Edwige; Fouépé Takounjou, Alain; Asai, Kazuyoshi; Bopda Djomou, Serges L.; Kusakabe, Minoru; Ohba, Takeshi; Tanyileke, Gregory; Hell, Joseph Victor; Ueda, Akira

    2015-04-01

    The shallow aquifer in the vicinity of Lake Nyos (Northwest, Cameroon) is one of the main water supply sources to meet the water needs of the inhabitants to be resettled after 1986s tragedy. Unfortunately, there is a lack of knowledge on the groundwater recharge and flow systems in the area. Multiple environmental tracers (δ18O, δD, Cl-, CFCs and SF6) and a yearly record of rainfall, surface waters and groundwater were employed to characterize the recharge mechanism of the shallow groundwater seeping in the fractured rock of the Lake Nyos catchment (LNC). The δ18O-δD relationship of the rainfall events gave the Nyos Meteoric Water Line: δD = 8.28 δ18O + 11.87. Inland moisture vapor may have impacted the isotopic composition of original vapor masses from Gulf of Guinea prior to precipitation. Shallow groundwater in the LNC shows a similar trend of enrichment in 18O and D as surface waters indicating a well-mixed aquifer. The proportions of surface waters and rainfall in the groundwater reservoir were 87% and 13%, respectively. The high annual recharge rate (941 mm/yr) and the seasonal variability in the isotopic signatures of groundwater indicate a renewable aquifer system. CFCs apparent ages-based piston flow model revealed a young age (average of 24 a.) of the groundwater in the LNC. SF6-based ages were biased young as compared to relatively younger than CFCs-based ages, implying an additional terrigenic production of SF6. The conceptual model for groundwater flow suggests that three main flow regimes, mainly controlled by the physical properties of the rock heterogeneities govern the movement of water in the aquifer. The piston flow model appears, however, to be the better model to explain the flow regime in the highly faulted and fissured area where recharge occurs (∼1200-1600 masl). The rapid circulation and the low solubility lead to low mineralization. In the middle-lower area where waters circulate more in the weathered layer, exponential mixing

  8. Application of the hypothesis of Developmental Origin of Health and Diseases (DOHaD) in epidemiological studies of women at reproductive age and pregnant women in Poland.

    PubMed

    Wojtyła, Andrzej

    2011-01-01

    Epidemiological population studies indicate that the nutrition of women at reproductive age and during pregnancy exerts an eff ect not only on the term of delivery, development of the foetus and birth weight, but also on the susceptibility of off spring to civilization diseases in adulthood, according to the hypothesis of Developmental Origin of Heath and Diseases (DOHaD). The author analyses the results of epidemiological studies conducted in 2011 in a randomly selected representative population of 6,000 Polish adolescents aged 14-24 (of the total of adolescents, a population of females was selected for analysis), and the results of foetal period health monitoring of mother and child (PRAMS) which has been conducted in Poland since 2009 in the population of mothers and their newborn babies staying after delivery in all hospitals in Poland. Analysis of these two population studies indicates that a high percentage of Polish women at reproductive age are dieting. At the same time, confirmation of the fact of becoming pregnant occurs between weeks 5-8 after conception. This shows that until that time, the foetuses of women on the Apple weight loss diet develop conditions of nutritional deficits which, according to the DOHaD hypothesis, may result in epigenetic changes which increase the susceptibility of off spring in adulthood to civilization diseases: cardiovascular disorders, type 2 diabetes or metabolic syndrome. This hypothesis is confirmed by the high percentages of newborns in Poland born with low birth weight or prematurely born, as well as the fact that the percentage of anemia in pregnant Polish women is twice as high as in other developed countries. Simultaneously, a large number of babies are born with excessive birth weight (macrosomia). The author considers that in the countries of East-Central Europe the phenomenon observed is characteristic at present of the developing countries of the Third World, called the 'double burden of malnutrition'. This

  9. May the Circle Be Unbroken: A New Decade. Final Report on the National Indian Conference on Aging (3rd, Albuquerque, New Mexico, September 8-10, 1980).

    ERIC Educational Resources Information Center

    National Indian Council on Aging, Albuquerque, NM.

    Focusing on six major topics to be addressed at the 1981 White House Conference (economic security, physical and mental health, social well being, older Americans as a national resource, creating an age-integrated society, and research), the National Indian Conference attracted 1,165 persons from more than 140 tribes (592 being Indian elders over…

  10. Genomic epidemiology of age-associated meningococcal lineages in national surveillance: an observational cohort study

    PubMed Central

    Hill, Dorothea M C; Lucidarme, Jay; Gray, Stephen J; Newbold, Lynne S; Ure, Roisin; Brehony, Carina; Harrison, Odile B; Bray, James E; Jolley, Keith A; Bratcher, Holly B; Parkhill, Julian; Tang, Christoph M; Borrow, Ray; Maiden, Martin C J

    2015-01-01

    Summary Background Invasive meningococcal disease (IMD) is a worldwide health issue that is potentially preventable with vaccination. In view of its sporadic nature and the high diversity of Neisseria meningitidis, epidemiological surveillance incorporating detailed isolate characterisation is crucial for effective control and understanding the evolving epidemiology of IMD. The Meningitis Research Foundation Meningococcus Genome Library (MRF-MGL) exploits whole-genome sequencing (WGS) for this purpose and presents data on a comprehensive and coherent IMD isolate collection from England and Wales via the internet. We assessed the contribution of these data to investigating IMD epidemiology. Methods WGS data were obtained for all 899 IMD isolates available for England and Wales in epidemiological years 2010–11 and 2011–12. The data had been annotated at 1720 loci, analysed, and disseminated online. Information was also available on meningococcal population structure and vaccine (Bexsero, GlaxoSmithKline, Brentford, Middlesex, UK) antigen variants, which enabled the investigation of IMD-associated genotypes over time and by patients' age groups. Population genomic analyses were done with a hierarchical gene-by-gene approach. Findings The methods used by MRF-MGL efficiently characterised IMD isolates and information was provided in plain language. At least 20 meningococcal lineages were identified, three of which (hyperinvasive clonal complexes 41/44 [lineage 3], 269 [lineage 2], and 23 [lineage 23]) were responsible for 528 (59%) of IMD isolates. Lineages were highly diverse and showed evidence of extensive recombination. Specific lineages were associated with IMD in particular age groups, with notable diversity in the youngest and oldest individuals. The increased incidence of IMD from 1984 to 2010 in England and Wales was due to successive and concurrent epidemics of different lineages. Genetically, 74% of isolates were characterised as encoding group B capsules

  11. A national survey of Rett syndrome: age, clinical characteristics, current abilities, and health.

    PubMed

    Cianfaglione, Rina; Clarke, Angus; Kerr, Mike; Hastings, Richard P; Oliver, Chris; Felce, David

    2015-07-01

    As part of a wider study to investigate the behavioral phenotype of a national sample of girls and women with Rett syndrome (RTT) in comparison to a well-chosen contrast group and its relationship to parental well-being, the development, clinical severity, current abilities and health of 91 participants were analyzed in relation to diagnostic, clinical and genetic mutation categories. Early truncating mutations or large deletions were associated with greater severity. Early regression was also associated with greater severity. All three were associated with lower current abilities. Epilepsy and weight, gastrointestinal and bowel problems were common co-morbidities. Participants with classic RTT had greater health problems than those with atypical RTT. A substantial minority of respondents reported fairly frequent signs of possible pain experienced by their relative with RTT. Overall, the study provides new data on the current abilities and general health of people with RTT and adds to the evidence that the severity of the condition and variation of subsequent disability, albeit generally within the profound range, may be related to gene mutation. The presence of certain co-morbidities represents a substantial ongoing need for better health. The experience of pain requires further investigation. PMID:25820775

  12. Aging with a disability: views from the National Institute on Disability and Rehabilitation Research.

    PubMed

    Seelman, K

    1999-01-01

    As I move toward the completion of my term as Director of the National Institute on Disability and Rehabilitation Research (NIDRR), I see many examples of renewal in our field. For example, disability studies and rehabilitation science are emerging new areas of academic specialization, and we will all be involved in shaping the future of these endeavors. The field is recapturing its identity and relevance locally and internationally. Also, I see a considerable number of challenges that range from acute care in medical rehabilitation to universal design in engineering to overall technology policy. I see a challenge in moving research to practice, a challenge in funding, a challenge in service delivery locations, and a challenge in defining the role of the professional in order to build capacity for the future. I believe that the research field ignores practice at its own peril, including practice in older fields such as vocational rehabilitation and in newer fields such as cognitive science and access engineering. Practice must be determined by today's needs and those we foresee for tomorrow. For the NIDRR family, the Long-Range Plan provides a beacon to direct us into the new millennium.

  13. A national survey of Rett syndrome: age, clinical characteristics, current abilities, and health.

    PubMed

    Cianfaglione, Rina; Clarke, Angus; Kerr, Mike; Hastings, Richard P; Oliver, Chris; Felce, David

    2015-07-01

    As part of a wider study to investigate the behavioral phenotype of a national sample of girls and women with Rett syndrome (RTT) in comparison to a well-chosen contrast group and its relationship to parental well-being, the development, clinical severity, current abilities and health of 91 participants were analyzed in relation to diagnostic, clinical and genetic mutation categories. Early truncating mutations or large deletions were associated with greater severity. Early regression was also associated with greater severity. All three were associated with lower current abilities. Epilepsy and weight, gastrointestinal and bowel problems were common co-morbidities. Participants with classic RTT had greater health problems than those with atypical RTT. A substantial minority of respondents reported fairly frequent signs of possible pain experienced by their relative with RTT. Overall, the study provides new data on the current abilities and general health of people with RTT and adds to the evidence that the severity of the condition and variation of subsequent disability, albeit generally within the profound range, may be related to gene mutation. The presence of certain co-morbidities represents a substantial ongoing need for better health. The experience of pain requires further investigation.

  14. National differences in environmental concern and performance are predicted by country age.

    PubMed

    Hershfield, Hal E; Bang, H Min; Weber, Elke U

    2014-01-01

    There are obvious economic predictors of ability and willingness to invest in environmental sustainability. Yet, given that environmental decisions represent trade-offs between present sacrifices and uncertain future benefits, psychological factors may also play a role in country-level environmental behavior. Gott's principle suggests that citizens may use perceptions of their country's age to predict its future continuation, with longer pasts predicting longer futures. Using country- and individual-level analyses, we examined whether longer perceived pasts result in longer perceived futures, which in turn motivate concern for continued environmental quality. Study 1 found that older countries scored higher on an environmental performance index, even when the analysis controlled for country-level differences in gross domestic product and governance. Study 2 showed that when the United States was framed as an old country (vs. a young one), participants were willing to donate more money to an environmental organization. The findings suggest that framing a country as a long-standing entity may effectively prompt proenvironmental behavior. PMID:24264938

  15. National differences in environmental concern and performance are predicted by country age.

    PubMed

    Hershfield, Hal E; Bang, H Min; Weber, Elke U

    2014-01-01

    There are obvious economic predictors of ability and willingness to invest in environmental sustainability. Yet, given that environmental decisions represent trade-offs between present sacrifices and uncertain future benefits, psychological factors may also play a role in country-level environmental behavior. Gott's principle suggests that citizens may use perceptions of their country's age to predict its future continuation, with longer pasts predicting longer futures. Using country- and individual-level analyses, we examined whether longer perceived pasts result in longer perceived futures, which in turn motivate concern for continued environmental quality. Study 1 found that older countries scored higher on an environmental performance index, even when the analysis controlled for country-level differences in gross domestic product and governance. Study 2 showed that when the United States was framed as an old country (vs. a young one), participants were willing to donate more money to an environmental organization. The findings suggest that framing a country as a long-standing entity may effectively prompt proenvironmental behavior.

  16. Neuroimaging of cognitive dysfunction and depression in aging retired National Football League players: a cross-sectional study.

    PubMed

    Hart, John; Kraut, Michael A; Womack, Kyle B; Strain, Jeremy; Didehbani, Nyaz; Bartz, Elizabeth; Conover, Heather; Mansinghani, Sethesh; Lu, Hanzhang; Cullum, C Munro

    2013-03-01

    OBJECTIVES To assess cognitive impairment and depression in aging former professional football (National Football League [NFL]) players and to identify neuroimaging correlates of these dysfunctions. DESIGN We compared former NFL players with cognitive impairment and depression, cognitively normal retired players who were not depressed, and matched healthy control subjects. SETTING Research center in the North Texas region of the United States. PATIENTS Cross-sectional sample of former NFL players with and without a history of concussion recruited from the North Texas region and age-, education-, and IQ-matched controls. Thirty-four retired NFL players (mean age, 61.8 years) underwent neurological and neuropsychological assessment. A subset of 26 players also underwent detailed neuroimaging; imaging data in this subset were compared with imaging data acquired in 26 healthy matched controls. MAIN OUTCOME MEASURES Neuropsychological measures, clinical diagnoses of depression, neuroimaging mea-sures of white matter pathology, and a measure of cerebral blood flow. RESULTS Of the 34 former NFL players, 20 were cognitively normal. Four were diagnosed as having a fixed cognitive deficit; 8, mild cognitive impairment; 2, dementia; and 8, depression. Of the subgroup in whom neuroimaging data were acquired, cognitively impaired participants showed the greatest deficits on tests of naming, word finding, and visual/verbal episodic memory. We found significant differences in white matter abnormalities in cognitively impaired and depressed retired players compared with their respective controls. Regional blood flow differences in the cognitively impaired group (left temporal pole, inferior parietal lobule, and superior temporal gyrus) corresponded to regions associated with impaired neurocognitive performance (problems with memory, naming, and word finding). CONCLUSIONS Cognitive deficits and depression appear to be more common in aging former NFL players compared with healthy

  17. New age and geochemical constraints on the origin of Quaternary adakite-like lavas in the Arabia-Eurasia collision zone

    NASA Astrophysics Data System (ADS)

    Pang, Kwan-Nang; Chung, Sun-Lin; Zarrinkoub, Mohammad Hossein; Li, Xian-Hua; Lee, Hao-Yang; Lin, Te-Hsien; Chiu, Han-Yi

    2016-11-01

    Adakite-like lavas from the Iranian segment of the Arabia-Eurasia collision zone have been considered as partial melts derived from a subducted Neotethyan slab, a hypothesis that cannot be further evaluated due to the lack of systematic age and radiogenic isotopic data. Here, we revisit the Anar region, Iran where such lavas were reported by providing these data to examine their probable origin as slab melts. New SIMS zircon U-Pb ages attest to eruption at ca. 1 to 2 Ma, postdating the Arabia-Eurasia collision. The lavas are characterized by dacitic to rhyolitic, metaluminous to slightly peraluminous and trondhjemitic compositions, and incompatible element patterns similar to continental crustal rocks. Extreme depletion in Nb, Ta, Y and the heavy REE relative to the light and middle REEs reflects control by garnet and rutile. Except one sample presumably affected by secondary gain of radiogenic Sr, the depleted Sr-Nd-Hf isotopic compositions relative to the Bulk Silicate Earth [(87Sr/86Sr)i = 0.7040 to 0.7043; εNd(t) = + 3.2 to + 5.3; εHf(t) = + 10.5 to + 11.3] indicate magma genesis from juvenile source rocks. A slab melt origin for the Anar lavas is very unlikely and the reason is twofold. First, the Y and HREE of the source rocks estimated by inversed batch melting models assuming garnet pyroxenite residue are far too low compared with MORB-like lithologies and subducted sediments. Second, the low MgO, Ni and Cr of the lavas point to limited interaction with peridotites in a mantle wedge. Fractionation-related models are also unlikely due to the apparent lack of broadly coeval, mafic precursor magmas without adakitic signature. The low-Y and low-HREE source rocks revealed by the melting models, together with the low MgO, Ni and Cr of the Anar lavas, can be explained by lower crustal melting under eclogite-facies conditions. These source rocks were most likely high-pressure cumulates in the root of the Urumieh-Dokhtar magmatic arc, a Neotethyan arc that was

  18. Vitamin B12 status in women of childbearing age in the UK and its relationship with national nutrient intake guidelines: results from two National Diet and Nutrition Surveys

    PubMed Central

    Adaikalakoteswari, Antonysunil; Venkataraman, Hema; Maheswaran, Hendramoorthy; Saravanan, Ponnusamy

    2016-01-01

    Objective To assess serum B12, folate and the associated homocysteine (Hcy) levels among women of childbearing age in the UK and examine their association with dietary intake in relation to the UK Recommended Nutrient Intakes (RNIs) for B12 and folate. Design Cross-sectional study. Setting Data from two publicly available National Diet and Nutrition Surveys (NDNS 2000/2001 and 2008/2012) were used. These were population-based surveys of randomly selected samples of adults which were carried out in their households. Participants Women of childbearing age (aged 19–39 years), representative of the UK population. Those who were pregnant or breastfeeding were excluded. Outcome measures The associations between micronutrient intakes and blood levels of B12, folate and Hcy were assessed by correlation and stepwise linear regression. B12 intake was divided into quintiles and plotted against blood B12 and Hcy concentrations to determine the threshold of any associations. Results 299 women from the first NDNS cohort had complete intake and biomarker data. The prevalence of serum vitamin B12 (≤150 pmol/L) and serum folate (≤10 nmol/L) deficiency and hyperhomocysteinemia (≥12 µmol/L) was 12.4%, 6.4% and 21.2%, respectively, despite seemingly adequate B12 intakes (median 3.8 μg/day, 96% consumed more than the UK RNI of 1.5 μg/day). B12 concentrations increased across all quintiles of intake with serum levels in quintiles 4 and 5 (median intake 4.9 and 7.1 μg/day, respectively) significantly higher than quintile 1. However, Hcy concentrations levelled off between quintiles 4 and 5. Comparison of micronutrient intake between the two surveys found that folate intake has reduced in the more recent cohort. Conclusions The UK RNI for B12 intake should be increased for women of childbearing age with intakes of around 5–7 μg/day likely to be associated with stable biomarker levels. B12 levels should also be measured in women preconceptionally or in early

  19. Geographic Variation and Factors Associated with Female Genital Mutilation among Reproductive Age Women in Ethiopia: A National Population Based Survey

    PubMed Central

    Setegn, Tesfaye; Lakew, Yihunie; Deribe, Kebede

    2016-01-01

    Background Female genital mutilation (FGM) is a common traditional practice in developing nations including Ethiopia. It poses complex and serious long-term health risks for women and girls and can lead to death. In Ethiopia, the geographic distribution and factors associated with FGM practices are poorly understood. Therefore, we assessed the spatial distribution and factors associated with FGM among reproductive age women in the country. Method We used population based national representative surveys. Data from two (2000 and 2005) Ethiopian demographic and health surveys (EDHS) were used in this analysis. Briefly, EDHS used a stratified, two-stage cluster sampling design. A total of 15,367 (from EDHS 2000) and 14,070 (from EDHS 2005) women of reproductive age (15–49 years) were included in the analysis. Three outcome variables were used (prevalence of FGM among women, prevalence of FGM among daughters and support for the continuation of FGM). The data were weighted and descriptive statistics (percentage change), bivariate and multivariable logistic regression analyses were carried out. Multicollinearity of variables was assessed using variance inflation factors (VIF) with a reference value of 10 before interpreting the final output. The geographic variation and clustering of weighted FGM prevalence were analyzed and visualized on maps using ArcGIS. Z-scores were used to assess the statistical difference of geographic clustering of FGM prevalence spots. Result The trend of FGM weighted prevalence has been decreasing. Being wealthy, Muslim and in higher age categories are associated with increased odds of FGM among women. Similarly, daughters from Muslim women have increased odds of experiencing FGM. Women in the higher age categories have increased odds of having daughters who experience FGM. The odds of FGM among daughters decrease with increased maternal education. Mass media exposure, being wealthy and higher paternal and maternal education are associated

  20. Geologic ages and accumulation rates of basalt-flow groups and sedimentary interbeds in selected wells at the Idaho National Engineering Laboratory, Idaho

    SciTech Connect

    Anderson, S.R.; Liszewski, M.J.; Cecil, L.D.

    1997-01-01

    Geologic ages and accumulation rates, estimated from regressions, were used to evaluate measured ages and interpreted stratigraphic and structural relations of basalt and sediment in the unsaturated zone and the Snake River Plain aquifer at the Idaho National Engineering Laboratory (INEL) in eastern Idaho. Geologic ages and accumulation rates were estimated from standard linear regressions of 21 mean potassium-argon (K-Ar) ages, selected mean paleomagnetic ages, and cumulative depths of a composite stratigraphic section composed of complete intervals of basalt and sediment that were deposited in areas of past maximum subsidence. Accumulation rates also were estimated from regressions of stratigraphic intervals in three wells in and adjacent to an area of interpreted uplift at and near the Idaho Chemical Processing Plant (ICPP) and the Test Reactor Area (TRA) to allow a comparison of rates in areas of past uplift and subsidence. Estimated geologic ages range from about 200 thousand to 1.8 million years before present and are reasonable approximations for the interval of basalt and sediment above the effective base of the aquifer, based on reported uncertainties of corresponding measured ages. Estimated ages between 200 and 800 thousand years are within the range of reported uncertainties for all 15 K-Ar ages used in regressions and two out of three -argon ({sup 40}Ar/{sup 39}Ar) ages of duplicate argon samples. Two sets of estimated ages between 800 thousand and 1.8 million years are within the range of reported uncertainties for all seven K-Ar ages used in regressions, which include one shared age of about 800 thousand years. Two sets of ages were estimated for this interval because K-Ar ages make up two populations that agree with previous and revised ages of three paleomagnetic subchrons. The youngest set of ages is consistent with a K-Ar age from the effective base of the aquifer that agrees with previous ages of the Olduvai Normal-Polarity Subchron.