Science.gov

Sample records for age range conclusions

  1. Educational Credentialing of an Aging Workforce: Uneasy Conclusions

    ERIC Educational Resources Information Center

    Isopahkala-Bouret, Ulpukka

    2015-01-01

    This study investigates the educational attainment of an aging workforce from the perspective of educational credentialing. The research questions are defined as follows: Why are workers over age 50 attaining university degrees? How do they narratively construct the rational for pursuing well-recognized credentials in midlife? The specific focus…

  2. Structural aging program -- a summary of activities, results, and conclusions

    SciTech Connect

    Naus, D.J.; Oland, C.B.; Ellingwood, B.R.

    1997-01-01

    Research has been conducted by the Oak Ridge National Laboratory to address aging management of nuclear power plant concrete structures. The purpose was to identify potential structural safety issues and acceptance criteria for use in continued service assessments. Primary program accomplishments have included formulation of a Structural Materials Information Center that contains data and information on the time variation of material properties under the influence of pertinent environmental stressors and aging factors for 144 materials, an aging assessment methodology to identify critical structures and degradation factors that can potentially impact their performance, guidelines and evaluation criteria for use in condition assessments of reinforced concrete structures, and a reliability-based methodology for current condition assessments and estimations of future performance of reinforced concrete nuclear power plant structures. In addition, the Structural Aging Program conducted in-depth evaluations of several nondestructive evaluation and repair-related technologies to develop guidance on their applicability.

  3. Personality-Informed Interventions for Healthy Aging: Conclusions from a National Institute on Aging Work Group

    ERIC Educational Resources Information Center

    Chapman, Benjamin P.; Hampson, Sarah; Clarkin, John

    2014-01-01

    We describe 2 frameworks in which personality dimensions relevant to health, such as Conscientiousness, can be used to inform interventions designed to promote health aging. First, contemporary data and theory do not suggest that personality is "immutable," but instead focus on questions of who changes, in what way, why, when, and how.…

  4. Personality-Informed Interventions for Healthy Aging: Conclusions From a National Institute on Aging Workgroup

    PubMed Central

    Chapman, Benjamin P.; Hampson, Sarah; Clarkin, John

    2013-01-01

    We describe two frameworks in which personality dimensions relevant to health, such as Conscientiousness, can be used to inform interventions designed to promote health aging. First, contemporary data and theory do not suggest that personality is “immutable”, but instead focus on questions of who changes, in what way, why, when, and how. In fact, the notion that personality could be changed was part and parcel of many schools of psychotherapy, which suggested that long term and meaningful change in symptoms could not be achieved without change in relevant aspects of personality. We review intervention research documenting change in personality. Based on an integrative view of personality as a complex system, we describe a “bottom-up” model of change in which interventions to change basic personality processes eventuate in changes at the trait level. A second framework leverages the descriptive and predictive power of personality to tailor individual risk prediction and treatment, as well as refine public health programs, to the relevant dispositional characteristics of the target population. These methods dovetail with and add a systematic and rigorous psychosocial dimension to the personalized medicine and patient-centeredness movements in medicine. In addition to improving health through earlier intervention and increased fit between treatments and persons, cost-effectiveness improvements can be realized by more accurate resource allocation. Numerous examples from the personality, health, and aging literature on Conscientiousness and other traits are provided throughout, and we conclude with a series of recommendations for research in these emerging areas. PMID:23978300

  5. Different partial volume correction methods lead to different conclusions: An (18)F-FDG-PET study of aging.

    PubMed

    Greve, Douglas N; Salat, David H; Bowen, Spencer L; Izquierdo-Garcia, David; Schultz, Aaron P; Catana, Ciprian; Becker, J Alex; Svarer, Claus; Knudsen, Gitte M; Sperling, Reisa A; Johnson, Keith A

    2016-05-15

    A cross-sectional group study of the effects of aging on brain metabolism as measured with (18)F-FDG-PET was performed using several different partial volume correction (PVC) methods: no correction (NoPVC), Meltzer (MZ), Müller-Gärtner (MG), and the symmetric geometric transfer matrix (SGTM) using 99 subjects aged 65-87years from the Harvard Aging Brain study. Sensitivity to parameter selection was tested for MZ and MG. The various methods and parameter settings resulted in an extremely wide range of conclusions as to the effects of age on metabolism, from almost no changes to virtually all of cortical regions showing a decrease with age. Simulations showed that NoPVC had significant bias that made the age effect on metabolism appear to be much larger and more significant than it is. MZ was found to be the same as NoPVC for liberal brain masks; for conservative brain masks, MZ showed few areas correlated with age. MG and SGTM were found to be similar; however, MG was sensitive to a thresholding parameter that can result in data loss. CSF uptake was surprisingly high at about 15% of that in gray matter. The exclusion of CSF from SGTM and MG models, which is almost universally done, caused a substantial loss in the power to detect age-related changes. This diversity of results reflects the literature on the metabolism of aging and suggests that extreme care should be taken when applying PVC or interpreting results that have been corrected for partial volume effects. Using the SGTM, significant age-related changes of about 7% per decade were found in frontal and cingulate cortices as well as primary visual and insular cortices. PMID:26915497

  6. Sweet Conclusion

    ERIC Educational Resources Information Center

    Shirley, Britt M.; Wooldridge, Barbara Ross; Camp, Kerri M.

    2012-01-01

    Jen Harrington is the owner and pastry chef of Sweet Conclusion, a bakery in Tampa, Florida. Most of Harrington's business comes from baking wedding cakes, but she has been attempting to attract customers to her retail bakery, where she sells cupcakes, pies, ice cream, and coffee. Nearly four years she opened Sweet Conclusion, the retail part of…

  7. Determination of Age-Dependent Reference Ranges for Coagulation Tests Performed Using Destiny Plus

    PubMed Central

    Arslan, Fatma Demet; Serdar, Muhittin; Merve Ari, Elif; Onur Oztan, Mustafa; Hikmet Kozcu, Sureyya; Tarhan, Huseyin; Cakmak, Ozgur; Zeytinli, Merve; Yasar Ellidag, Hamit

    2016-01-01

    Background In order to apply the right treatment for hemostatic disorders in pediatric patients, laboratory data should be interpreted with age-appropriate reference ranges. Objectives The purpose of this study was to determining age-dependent reference range values for prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen tests, and D-dimer tests. Materials and Methods A total of 320 volunteers were included in the study with the following ages: 1 month - 1 year (n = 52), 2 - 5 years (n = 50), 6 - 10 years (n = 48), 11 - 17 years (n = 38), and 18 - 65 years (n = 132). Each volunteer completed a survey to exclude hemostatic system disorder. Using a nonparametric method, the lower and upper limits, including 95% distribution and 90% confidence intervals, were calculated. Results No statistically significant differences were found between PT and aPTT values in the groups consisting of children. Thus, the reference ranges were separated into child and adult age groups. PT and aPTT values were significantly higher in the children than in the adults. Fibrinogen values in the 6 - 10 age group and the adult age group were significantly higher than in the other groups. D-dimer levels were significantly lower in those aged 2 - 17; thus, a separate reference range was established. Conclusions These results support other findings related to developmental hemostasis, confirming that adult and pediatric age groups should be evaluated using different reference ranges. PMID:27617078

  8. New radiocarbon ages from cirques in Colorado Front Range

    SciTech Connect

    Davis, P.T. . Dept. Natural Science); Birkeland, P.W. . Dept. Geological Science); Caine, N. . Dept. of Geography); Rodbell, D.T. )

    1992-01-01

    The authors recovered sediment cores 3.1 m long from Blue Lake ([approximately]37m water depth, [approximately]3,445m a.s.l., 40[degree]5 minutes 20 seconds N, 105[degree]37 minutes 08 seconds W) and 2.7m long from Lake Dorothy ([approximately]35m water depth, [approximately]3,675m a.s.l., 40[degree]00 minutes 46 seconds N, 105[degree]41 minutes 11 seconds W). A light-weight percussion coring system suspended from perlon ropes was used because of sediment thicknesses, water depths, and ski-backpacking requirements. Lake ice provided a stable coring platform. One purpose of the project is provision of a high-resolution record of environmental change in the subalpine/alpine ecotone during the Holocene, under the auspices of the Niwot Ridge Long-Term Ecological Research program. The sediment cores also provide minimum-limiting radiocarbon ages for deglaciation of cirques and the deposits that impound their tarns. Here the authors report on this second purpose. The Blue Lake core bottomed in sandy, gray, inorganic sediment, presumably glacial diamict. A bulk sample from 2.8--2.9m depth yielded a conventional radiocarbon age of 12,275[+-]345 yrs BP. Thus, ice retreated from the site by 12 ka. Since 12 ka both glacial and rock-glacial sediments have been deposited upvalley; some of these events may be recognized in the core. In contrast, the Lake Dorothy core did not penetrate gray inorganic diamict and is entirely organic-rich. A bulk sample from 2.65--2.7m depth yielded a conventional radiocarbon age of 10,910 [+-] 320 yrs BP. Thus, the moraines impounding the lake are 2--3 times older than suggested by a combination of relative-age methods and one radiocarbon age from surface sediments.

  9. Lunar surface dynamics: Some general conclusions and new results from Apollo 16 and 17. [exposure age determination of lunar rocks, boulders, and craters

    NASA Technical Reports Server (NTRS)

    Crozaz, G.; Drozd, R.; Hohenberg, C.; Morgan, C.; Ralston, C.; Walker, R.; Yuhas, D.

    1974-01-01

    Exposure ages of Apollo 17 rocks as measured by tracks and the Kr-Kr rare gas method are reported. Concordant ages of 22 - or + 1 million year (my) are obtained for the station 6 boulder sample 76315. This value is interpreted as the time when the station 6 boulder was emplaced in its present position. Reasonable agreement is also obtained by the two methods for another station 6 boulder, sample 76015. Discordant ages (respectively 5 and 28 my by the track and rare gas methods) are obtained for the station 7 boulder sample, 77135, indicating that the boulder was emplaced at least 5 my ago. The 72 my exposure age of 75035, in general agreement with previous measurements of approximately 85 my for another Camelot boulder, may well date the formation of Camelot. Rock 76015 was split and one surface exposed to the sky through a very small solid angle.

  10. [Forensic age estimation in juveniles and young adults: Reducing the range of scatter in age diagnosis by combining different methods].

    PubMed

    Schmidt, Sven; Schramm, Danilo; Ribbecke, Sebastian; Schulz, Ronald; Wittschieber, Daniel; Olze, Andreas; Vieth, Volker; Ramsthaler, H Frank; Pfischel, Klaus; Pfeiffer, Heidi; Geserick, Gunther; Schmeling, Andreas

    2016-01-01

    The dramatic rise in the number of refugees entering Germany means that age estimation for juveniles and young adults whose age is unclear but relevant to legal and official procedures has become more important than ever. Until now, whether and to what extent the combination of methods recommended by the Study Group on Forensic Age Diagnostics has resulted in a reduction of the range of scatter of the summarized age diagnosis has been unclear. Hand skeletal age, third molar mineralization stage and ossification stage of the medial clavicular epiphyses were determined for 307 individuals aged between 10 and 29 at time of death on whom autopsies were performed at the Institutes of Legal Medicine in Berlin, Frankfurt am Main and Hamburg between 2001 and 2011. To measure the range of scatter, linear regression analysis was used to calculate the standard error of estimate for each of the above methods individually and in combination. It was found that combining the above methods led to a reduction in the range of scatter. Due to various limitations of the study, the statistical parameters determined cannot, however, be used for age estimation practice. PMID:26934764

  11. Clues to Conclusions

    ERIC Educational Resources Information Center

    Soloway, Rhoda K.

    1978-01-01

    To help students learn how to interpret, infer, and speculate on conclusions, here is a week-long learning activity on "clue finding". A mitten, a bagful of debris and a few intriguing exercises with descriptive paragraphs show students that they use clues every day to draw conclusions and that they can extend this ability to analyze what they…

  12. Differential Range Use between Age Classes of Southern African Bearded Vultures Gypaetus barbatus

    PubMed Central

    Krüger, Sonja; Reid, Timothy; Amar, Arjun

    2014-01-01

    Bearded Vulture Gypaetus barbatus movements were investigated in southern Africa to determine whether an individual's age, sex or breeding status influenced its ranging behaviour and to provide the information required to guide conservation activities. Data from satellite transmitters fitted to 18 individuals of four age classes were used to determine range size and use. Because of the nature of the movements of marked individuals, these data could be used to determine the overall foraging range of the entire population, which was estimated to be 51 767 km2. Although juvenile, immature and sub-adult birds used different parts of the overall range, their combined foraging range was 65% (33 636 km2) of the overall range. Average adult home ranges (286 km2) were only around 1% the size of the average foraging ranges of non-adults (10 540 –25 985 km2), with those of breeding adults being even smaller (95 km2). Home ranges of breeding adults did not vary in size between seasons but adults utilized their home range more intensively whilst breeding, moving greater distances during the incubation and chick hatching period. Range size and use increased as non-adults aged. Immatures and sub-adults had larger range sizes during winter, but range use of non-adults did not vary seasonally. Range size and use did not differ between the sexes in any of the age classes. Information on home range size and use enables specific areas within the species' range to be targeted for management planning, education and conservation action. PMID:25551614

  13. Differential range use between age classes of southern African Bearded Vultures Gypaetus barbatus.

    PubMed

    Krüger, Sonja; Reid, Timothy; Amar, Arjun

    2014-01-01

    Bearded Vulture Gypaetus barbatus movements were investigated in southern Africa to determine whether an individual's age, sex or breeding status influenced its ranging behaviour and to provide the information required to guide conservation activities. Data from satellite transmitters fitted to 18 individuals of four age classes were used to determine range size and use. Because of the nature of the movements of marked individuals, these data could be used to determine the overall foraging range of the entire population, which was estimated to be 51 767 km(2). Although juvenile, immature and sub-adult birds used different parts of the overall range, their combined foraging range was 65% (33 636 km(2)) of the overall range. Average adult home ranges (286 km(2)) were only around 1% the size of the average foraging ranges of non-adults (10 540 -25 985 km(2)), with those of breeding adults being even smaller (95 km(2)). Home ranges of breeding adults did not vary in size between seasons but adults utilized their home range more intensively whilst breeding, moving greater distances during the incubation and chick hatching period. Range size and use increased as non-adults aged. Immatures and sub-adults had larger range sizes during winter, but range use of non-adults did not vary seasonally. Range size and use did not differ between the sexes in any of the age classes. Information on home range size and use enables specific areas within the species' range to be targeted for management planning, education and conservation action. PMID:25551614

  14. Differential range use between age classes of southern African Bearded Vultures Gypaetus barbatus.

    PubMed

    Krüger, Sonja; Reid, Timothy; Amar, Arjun

    2014-01-01

    Bearded Vulture Gypaetus barbatus movements were investigated in southern Africa to determine whether an individual's age, sex or breeding status influenced its ranging behaviour and to provide the information required to guide conservation activities. Data from satellite transmitters fitted to 18 individuals of four age classes were used to determine range size and use. Because of the nature of the movements of marked individuals, these data could be used to determine the overall foraging range of the entire population, which was estimated to be 51 767 km(2). Although juvenile, immature and sub-adult birds used different parts of the overall range, their combined foraging range was 65% (33 636 km(2)) of the overall range. Average adult home ranges (286 km(2)) were only around 1% the size of the average foraging ranges of non-adults (10 540 -25 985 km(2)), with those of breeding adults being even smaller (95 km(2)). Home ranges of breeding adults did not vary in size between seasons but adults utilized their home range more intensively whilst breeding, moving greater distances during the incubation and chick hatching period. Range size and use increased as non-adults aged. Immatures and sub-adults had larger range sizes during winter, but range use of non-adults did not vary seasonally. Range size and use did not differ between the sexes in any of the age classes. Information on home range size and use enables specific areas within the species' range to be targeted for management planning, education and conservation action.

  15. Beginning without a Conclusion.

    ERIC Educational Resources Information Center

    Frazier, Richard

    1988-01-01

    Describes a series of activities without conclusions to introduce scientific reasoning in a ninth grade physical science course. Uses popcorn popping to get students to think about the concepts of graphing, histograms, frequency, probability, and scientific methodology. (CW)

  16. Age and growth of mangrove red snapper Lutjanus argentimaculatus at its cool-water-range limits.

    PubMed

    Piddocke, T P; Butler, G L; Butcher, P A; Stewart, J; Bucher, D J; Christidis, L

    2015-05-01

    This study investigates the age and growth of Lutjanus argentimaculatus at its southern (cooler) range limits in eastern Australia. Specimens were collected from New South Wales and southern Queensland between November 2011 and December 2013. Fork lengths (LF ) ranged from 190 to 1019 mm, and ages ranged from 2+ to 57+ years. Growth was described by the von Bertalanffy growth function with coefficients L∞ = 874·92 mm, K = 0·087 year(-1) and t0 = -2·76 years. Estimates of the instantaneous natural mortality rate (M) ranged from 0·072 to 0·25. The LF (mm) and mass (W; g) relationship was represented by the equation: W=2·647×10-5LF2·92. The maximum age of 57+ years is the oldest reported for any lutjanid and comparisons with tropical studies suggest that the age-based demography of L. argentimaculatus follows a latitudinal gradient. High maximum ages and low natural mortality rates indicate considerable vulnerability to overexploitation at the species' cool-water-range limits. These results demonstrate the need to identify underlying processes driving latitudinal gradients in fish demography.

  17. Potassium-Argon Age from a Granite at Mount Wilbur, Queen Maud Range, Antarctica.

    PubMed

    Minshew, V H

    1965-11-01

    The basement complex of the Robert Scott Glacier area, Queen Maud Range, Antarctica, consists of a complex suite of metasedimentary and metavolcanic rocks intruded by light gray biotite granite. Brown biotite from a granite at Mount Wilbur was dated by the potassium-argon method at 470 +/- 14 million years; this age coincides closely with many other ages from granitic rocks in the Transantarctic Mountains.

  18. Refined analysis of the critical age ranges of childhood overweight: implications for primary prevention.

    PubMed

    Hoffmann, Sascha W; Ulrich, Rolf; Simon, Perikles

    2012-10-01

    Prevention-interventions would certainly benefit from a precise knowledge of the age range when the most pronounced increases in prevalence of overweight and obesity occur in the general population. Data of 15,662 subjects aged 2-18 years were obtained from a national representative health survey (German Health Interview and Examination Survey for Children and Adolescents (KiGGS)) conducted in Germany. Weight, height, and BMI z-scores were calculated relative to the UK 1990 reference, and prevalence of overweight and obesity was defined according to the IOTF (International Obesity Task Force) age- and sex-specific cut-offs. Univariate ANOVAs for overweight, obesity, weight, height, and BMI z-scores as dependent variables were employed to assess significant differences for these measures across various age levels. Significant analysis was followed by post-hoc comparisons using Bonferroni adjustments. The main effect of age was estimated using a multinomial logistic regression model, and by defining the first derivative of a polynomial spline function. Different eclectic slopes over the entire age range from 2 to 18 years have been observed. Prevalence of overweight substantially increases between the 5th and the 8th year (12.5-21.4%; P ≤ 0.001). Maximum increase of the polynomial fit was detected at 7.2 years. Our findings suggest a relatively narrow age range at the first school year when overweight in German children especially increases. We therefore propose that psychosocial correlates may be related to the general life-time event around the age of entering school.

  19. Towards a method for determining age ranges from faces of juveniles on photographs.

    PubMed

    Cummaudo, M; Guerzoni, M; Gibelli, D; Cigada, A; Obertovà, Z; Ratnayake, M; Poppa, P; Gabriel, P; Ritz-Timme, S; Cattaneo, C

    2014-06-01

    The steady increase in the distribution of juvenile pornographic material in recent years strongly required valid methods for estimating the age of the victims. At the present in fact forensic experts still commonly use the assessment of sexual characteristics by Tanner staging, although they have proven to be too subjective and deceiving for age estimation. The objective of this study, inspired by a previous EU project involving Italy, Germany and Lithuania, is to verify the applicability of certain anthropometric indices of faces in order to determine age and to create a database of facial measurements on a population of children in order to improve face ageing techniques. In this study, 1924 standardized facial images in frontal view and 1921 in lateral view of individuals from 7 age groups (3-5 years, 6-8 years, 9-11 years, 12-14 years, 15-17 years, 18-20 years, 21-24 years) underwent metric analysis. Individuals were all of Caucasoid ancestry and Italian nationality. Eighteen anthropometric indices in the frontal view and five in the lateral view were then calculated from the obtained measurements. Indices showing a correlation with age were ch-ch/ex-ex, ch-ch/pu-pu, en-en/ch-ch and se-sto/ex-ex in the frontal view, se-prn/se-sn, se-prn/se-sto and se-sn/se-sto in the lateral view. All the indices increased with age except for en-en/ch-ch, without relevant differences between males and females. These results provide an interesting starting point not only for placing a photographed face in an age range but also for refining the techniques of face ageing and personal identification. PMID:24726662

  20. Towards a method for determining age ranges from faces of juveniles on photographs.

    PubMed

    Cummaudo, M; Guerzoni, M; Gibelli, D; Cigada, A; Obertovà, Z; Ratnayake, M; Poppa, P; Gabriel, P; Ritz-Timme, S; Cattaneo, C

    2014-06-01

    The steady increase in the distribution of juvenile pornographic material in recent years strongly required valid methods for estimating the age of the victims. At the present in fact forensic experts still commonly use the assessment of sexual characteristics by Tanner staging, although they have proven to be too subjective and deceiving for age estimation. The objective of this study, inspired by a previous EU project involving Italy, Germany and Lithuania, is to verify the applicability of certain anthropometric indices of faces in order to determine age and to create a database of facial measurements on a population of children in order to improve face ageing techniques. In this study, 1924 standardized facial images in frontal view and 1921 in lateral view of individuals from 7 age groups (3-5 years, 6-8 years, 9-11 years, 12-14 years, 15-17 years, 18-20 years, 21-24 years) underwent metric analysis. Individuals were all of Caucasoid ancestry and Italian nationality. Eighteen anthropometric indices in the frontal view and five in the lateral view were then calculated from the obtained measurements. Indices showing a correlation with age were ch-ch/ex-ex, ch-ch/pu-pu, en-en/ch-ch and se-sto/ex-ex in the frontal view, se-prn/se-sn, se-prn/se-sto and se-sn/se-sto in the lateral view. All the indices increased with age except for en-en/ch-ch, without relevant differences between males and females. These results provide an interesting starting point not only for placing a photographed face in an age range but also for refining the techniques of face ageing and personal identification.

  1. Conclusion

    NASA Astrophysics Data System (ADS)

    Thoma, Klaus; Hiller, Daniel; Leismann, Tobias; Drees, Birgit

    Considering the breadth of perspectives in security research among Europeans, as exemplified within this publication, one may certainly note that a tremendous development of this young discipline has occurred in a short period of time. Only three years have passed since the discipline was promoted to an individual theme within the specific programme on `Cooperation' of the European Commission FP7. Since then, a conceptual framework has been established and the first collaborative projects have been executed on different levels, all at an impressive pace. Although the future of security research will remain closely linked to the political will of EU member states, the established base will serve as a solid foundation for the further development of the discipline on a European scale.

  2. Conclusion

    NASA Technical Reports Server (NTRS)

    Arnold, Steven M.; Wong, Terry T.

    2011-01-01

    This compilation of papers in this book represents approximately half of the works discussed at the MS&T 2010 symposium entitled Tools, Models, Databases, and Simulation Tools Developed and Needed to Realize the Vision of Integrated Computational Materials Engineering at Materials Science & Technology wherein five sessions comprised of 33 presentations was organized. The goal of the symposium was two fold To provide a forum in which current state-of-the-art methods for ICME (e.g., information informatics, experimentation, and modeling) could be openly discussed and critiqued by not only materials scientist but also structural engineers/researchers, component designers, industrial leaders and government program managers. To leave the symposium and in particular the panel discussion with a clear idea of the gaps and barriers (both technical, cultural and economical) that must be addressed in order for ICME to fully succeed. The organizers felt that these goals were met, as particularly evident by the standing room only attendance during a lively panel discussion session at the end of the Symposium. However it is the firm belief of the editors of this book that this symposium was merely a start in the right direction, and that subsequent conferences/symposium (e.g., First World Congress on Integrated Computational Materials Engineering to be held July 10-14, 2011 at Seven Springs Mountain Resort in Pennsylvania) must work hard to ensure that a truly diverse, multidisciplinary, community of researchers and practitioners are present and have ample opportunity for interaction. This will ensure that a proper balance between push and pull disciplines and technologies is maintained so that this emerging focus area, Integrated Computational Materials Engineering (ICME), has the greatest potential for success and impact on "system-level" payoffs. Similarly, a pro-active approach is required to reform historical modes of operation in industry, government and the academic sectors so as to facilitate multidisciplinary collaboration and to clearly articulate the vision and scope of ICME.

  3. Conclusions

    NASA Astrophysics Data System (ADS)

    Ahonen, Pasi; Alahuhta, Petteri; Daskala, Barbara; Delaitre, Sabine; Hert, Paul De; Lindner, Ralf; Maghiros, Ioannis; Moscibroda, Anna; Schreurs, Wim; Verlinden, Michiel

    Some say that an increase in security does not necessarily mean a further encroachment on privacy - indeed, security is necessary to protect personal data and our privacy. Networks must be secure, our personal devices, reliable, dependable and trustworthy. But security is a multifaceted term, with many dimensions. We are of the view that an increase in security most likely will encroach upon our privacy in an ambient intelligence world. Surveillance cameras will continue to proliferate. We assume that, whatever the law is, whatever privacy protections government and business say they honour, our telecommunications, e-mails and Internet usage will be monitored to an increasing degree. The same will be true of our interfaces with the world of ambient intelligence.

  4. Conclusion

    NASA Astrophysics Data System (ADS)

    Ivancevic, Vladimir G.; Reid, Darryn J.

    2015-11-01

    It is often held that things should always be made simple, which presumes that either that they can always be made simple or that all the jetisoned logic doesn't matter anyway. Alledgedly, anything should be explainable so that anyone can understand it. Don't get bogged down in dreary details. It should be effortless for the reader: low-dimensional systems exhibit complex behaviour while high-dimensional systems exhibit simple behaviour (to return to our prolegomonal opening), competition is a universal solution, demand must increase as price falls, and everything under the sun neatly fits a power law. Or so the story goes...

  5. Reference Ranges of Age-Related Prostate-Specific Antigen in Men without Cancer from Beijing Area

    PubMed Central

    Liu, Xin; Wang, Jie; Zhang, Shun-Xin; Lin, Qian

    2013-01-01

    Abstract Background To determine the normal ranges of serum age-related prostate-specific antigen (PSA) level in men from Beijing area without cancer. Methods In this cross sectional study, form April 2010 to October 2011, 1611 healthy men undergoing a routine health check-up in our hospital and all men received three examinations including serum PSA test, digital rectal ex-amination and transrectal ultrasound. Men with any two abnormal results of the three examinations were undergone a prostate biopsy. Men with any two normal results of the three examinations or with negative biopsy were defined as men without cancer. Men with a prior history of prostate cancer/surgery or with urinary tract infection/obstruction were excluded. 1572 men without cancer were recruited into the study finally and were stratified into 10-year age groups: 40 to 49, 50 to 59, 60 to 69, 70 to 79, and older than 80. Results The median PSA value (95th percentile range) was 0.506(1.565), 1.04(2.920), 1.16(4.113), 1.34(5.561)and 2.975 (7.285) for each age group respectively, and the 25th percentile to 75 percentile was 0.343 to 0.923, 0.663 to 1.580, 0.693 to 2.203, 0.789 to 2.368 and 1.188 to 4.295 respectively. The serum PSA value is directly correlated with age (r=0.314, P<0.001). Conclusions Use the age-related range for PSA increases the sensitivity in younger men and decreases the biopsy rate in older patients. PMID:26171333

  6. Reduction of Optimal Thermal Range in Aging Western Cherry Fruit Flies (Diptera: Tephritidae)

    PubMed Central

    Neven, Lisa G.

    2015-01-01

    The western cherry fruit fly is an economically important pest of sweet cherries in the western United States. The potential of this pest to establish and spread in areas in which it is not currently present has been the focus of recent research. Most published information on the thermal tolerance and optimal thermal range of this pest has focused primarily on the diapausing pupae and predictive phenology models. Microrespirometry and differential calorimetry can be useful tools in describing the thermotolerance and optimal thermal range of insects. This methodology was employed to investigate the effects of western cherry fruit fly adult age on the optimal thermal range. Newly emerged flies exhibited the widest optimal thermal range spanning from 6.6 to 42.2°C for a total range of 35.8°C during heating scans of 0.4°C/min from 2 to 50°C. This range diminished as the flies aged, with the shortest span observed with 28-d-old flies ranging from 10.5 to 37.8°C, a span of 27.2°C. Measurements of heat rate and oxygen consumption at isothermal, or static, temperatures indicated that all flies could survive exposure to 40°C for at least 20 min, and that metabolism was greatly reduced, with a concomitant reduction in oxygen consumption rate at 40 to 42°C. All flies exhibited a heat rate and oxygen consumption rate of zero when exposed to 45 and 50°C. The loss of thermotolerance in adult flies can influence its ability to establish and spread in climates where daily temperatures exceed the optimal thermal range of this species. PMID:26106089

  7. Reduction of Optimal Thermal Range in Aging Western Cherry Fruit Flies (Diptera: Tephritidae).

    PubMed

    Neven, Lisa G

    2015-01-01

    The western cherry fruit fly is an economically important pest of sweet cherries in the western United States. The potential of this pest to establish and spread in areas in which it is not currently present has been the focus of recent research. Most published information on the thermal tolerance and optimal thermal range of this pest has focused primarily on the diapausing pupae and predictive phenology models. Microrespirometry and differential calorimetry can be useful tools in describing the thermotolerance and optimal thermal range of insects. This methodology was employed to investigate the effects of western cherry fruit fly adult age on the optimal thermal range. Newly emerged flies exhibited the widest optimal thermal range spanning from 6.6 to 42.2°C for a total range of 35.8°C during heating scans of 0.4°C/min from 2 to 50°C. This range diminished as the flies aged, with the shortest span observed with 28-d-old flies ranging from 10.5 to 37.8°C, a span of 27.2°C. Measurements of heat rate and oxygen consumption at isothermal, or static, temperatures indicated that all flies could survive exposure to 40°C for at least 20 min, and that metabolism was greatly reduced, with a concomitant reduction in oxygen consumption rate at 40 to 42°C. All flies exhibited a heat rate and oxygen consumption rate of zero when exposed to 45 and 50°C. The loss of thermotolerance in adult flies can influence its ability to establish and spread in climates where daily temperatures exceed the optimal thermal range of this species.

  8. Middle Jurassic U-Pb crystallization age for Siniktanneyak Mountain ophiolite, Brooks Range, Alaska

    SciTech Connect

    Moore, T.E. ); Aleinikoff, J.N.; Walter, M. )

    1993-04-01

    The authors report here a U-Pb age for the Siniktanneyak Mountain Ophiolite klippe in the west-central Brooks Range, the first U-Pb ophiolite age in northern Alaska. Like klippen of mafic and ultramafic rocks in the Brooks Range, the Siniktanneyak Mountain klippe is composed of a lower allochthon of Devonian and younger( ) diabase and metabasalt with trace-element characteristics of seamount basalts and an upper allochthon of ophiolite. The ophiolite is partial, consisting of (1) abundant dunite and subordinate harzburgite and wehrlite; (2) cumulate clinopyroxene gabbro, and (3) minor noncumulate clinopyroxene gabbro and subordinate plagiogranite; no sheeted dikes or volcanic rocks are known in the ophilitic allochthon. The plagiogranite forms small dikes and stocks that intrude the noncumulate gabbro and consists of zoned Na-rich plagioclase + clinopyroxene with interstial quartz and biotite. Five fractions of subhedral, tan zircon from the plagiogranite yield slightly discordant U-Pb data with an upper intercept age of 170 [+-] 3 Ma. The U-Pb data indicate that the Siniktanneyak Mountain ophiolite crystallized in the Middle Jurassic and was emplaced by thrusting onto mafic accretionary prism rocks within about 10 m.y. of crystallization. The U-Pb data provide an upper limit to the age of initiation of the Brookian orogeny.

  9. Mechanical properties of bulk polydimethylsiloxane for microfluidics over a large range of frequencies and aging times

    NASA Astrophysics Data System (ADS)

    Placet, V.; Delobelle, P.

    2015-03-01

    The dynamic mechanical characterization of polydimethylsiloxane (PDMS) over a large range of frequencies (10-2 < f < 105 Hz) and long aging times at room temperature (4 h < tv < ~60 000 h) has been presented. Three samples with different curing conditions have been studied and three different techniques, dynamic mechanical analysis at different temperatures, nano-indentation and scanning micro-deformation microscopy, have been used. Although the three techniques work at different scales and at different frequencies all the results match the same master curve. As expected, the storage and the loss moduli greatly increase with the frequency. Moreover, these moduli moderately increase with the aging time tv depending on the curing temperature. A simple model which takes the frequency and the aging time into account, and which is based on the Havriliak-Negami model, has been presented and identified. Hence, values of the relaxed and instantaneous moduli at tv = 0 and tv = ∞ are proposed. Only the relaxed moduli depend on the curing conditions and moreover it has been shown that the tangent of the phase lag is independent of the aging time and thus of the curing process.

  10. Zircon fission-track ages from the Gasherbrum Diorite, Karakoram Range, northern Pakistan

    SciTech Connect

    Cerveny, P.F. ); Naeser, C.W. ); Kelemen, P.B. ); Lieberman, J.E. ); Zeitler, P.K. )

    1989-11-01

    The Gasherbrum Peaks, in the Himalaya of Pakistan, reach elevations of >8000 m. The relief between the peaks and the adjacent valley (Baltoro Glacier) is in excess of 3000 m. Eight samples of the Early Cretaceous Gasherbrum Diorite at elevations between 4880 and 7165 m on Gasherbrum IV were collected for fission-track dating. Zircon fission-track ages from the Gasherbrum Diorite vary from Early Cretaceous to middle Tertiary in age. There is no consistent pattern between age and elevation. The Cretaceous ages indicate that these rocks were never deeply buried, i.e., heated to temperatures in excess of 175 C, to reset the zircons during Cenozoic time. These results also indicate that the uplift of this part of the Himalaya has been either very rapid and recent, or very slow since Early Cretaceous time. This latter possibility is not consistent with the high relief at Gasherbrum and what is known about regional tectonics. Gasherbrum IV zircons, currently at {approximately}4880 m, have never been at depths greater than 6 km, and less than 3 km of material has been removed from the top of the range by erosion since the Early Cretaceous. Rapid uplift has occurred very recently, and erosion rates have not been able to keep pace with this uplift.

  11. Assessment Of Noise-induced Sleep Fragility In Two Age Ranges By Means Of Polysomnographic Microstructure

    NASA Astrophysics Data System (ADS)

    Terzano, M. G.; Parrino, L.; Spaggiari, M. C.; Buccino, G. P.; Fioriti, G.; Depoortere, H.

    1993-04-01

    The microstructure of sleep, which translates the short-lived fluctuations of the arousal level, is a commonly neglected feature in polysomnographic studies. Specifically arranged microstructural EEG events may provide important information on the dynamic characteristics of the sleep process. CAP (cyclic alternating pattern) and non-CAP are complementary modalities in which arousal-related "phasic" EEG phenomena are organized in non-REM sleep, and they correspond to opposite conditions of unstable and stable sleep depth, respectively. Thus, arousal instability can be measured by the CAP rate, the percentage ratio of total CAP time to total non-REM sleep time. The CAP rate, an age-related physiological variable that increases in several pathological conditions, is highly sensitive to acoustic perturbation. In the present study, two groups of healthy subjects without complaints about sleep, belonging to different age ranges (six young adults, three males and three females, between 20 and 30 years, and six middle-aged individuals, three males and three females, between 40 and 55 years) slept, after adaptation to the sleep laboratory, in a random sequence for two non-consecutive nights either under silent baseline (27·3 dB(A) Lcq) or noise-disturbed (continuous 55 dB(A) white noise) conditions. Age-related and noise-related effects on traditional sleep parameters and on the CAP rate were statistically evaluated by a split-plot test. Compared to young adults, the middle-aged individuals showed a significant reduction of total sleep time, stage 2 and REM sleep and significantly higher values of nocturnal awakenings and the CAP rate. The noisy nights were characterized by similar alterations. The disruptive effects of acoustic perturbation were greater on the more fragile sleep architecture of the older group. The increased fragility of sleep associated with aging probably reflects the decreased capacity of the sleeping brain to maintain steady states of vigilance. Total

  12. Theoretical constraints on the precision and age range of rehydroxylation dating

    PubMed Central

    Hare, V. J.

    2015-01-01

    Accurate and precise dating methods are of central importance to archaeology, palaeontology and earth science. This paper investigates the expected precision and age range of rehydroxylation dating, a recently proposed technique for fired clays. An expression for combined measurement uncertainty is presented, which takes into account all significant sources of experimental uncertainty. Numerical simulations are performed for comparison. Combined measurement uncertainties of approximately 5% with respect to the age of the ceramic should be possible given well-designed experiments. In this case, the most significant contribution to combined measurement uncertainty is from effective lifetime temperature. In addition, it is shown that precision should be acceptable for recently fired material (less than 1 year). Mismatch of balance resolution to sample mass results in large variation in combined relative uncertainties, which vary by four orders of magnitude (approx. 1–1160%) across recent experimental studies, rendering some recently reported dates meaningless. It is recommended that this ratio be less than 10−6 for a combined relative uncertainty of less than 1%. The age limits of the technique are set by the value of the rate constant and individual sample mineralogy. This theoretical framework should help future interlaboratory comparison as well as optimizing instrument design. PMID:26064631

  13. Theoretical constraints on the precision and age range of rehydroxylation dating.

    PubMed

    Hare, V J

    2015-04-01

    Accurate and precise dating methods are of central importance to archaeology, palaeontology and earth science. This paper investigates the expected precision and age range of rehydroxylation dating, a recently proposed technique for fired clays. An expression for combined measurement uncertainty is presented, which takes into account all significant sources of experimental uncertainty. Numerical simulations are performed for comparison. Combined measurement uncertainties of approximately 5% with respect to the age of the ceramic should be possible given well-designed experiments. In this case, the most significant contribution to combined measurement uncertainty is from effective lifetime temperature. In addition, it is shown that precision should be acceptable for recently fired material (less than 1 year). Mismatch of balance resolution to sample mass results in large variation in combined relative uncertainties, which vary by four orders of magnitude (approx. 1-1160%) across recent experimental studies, rendering some recently reported dates meaningless. It is recommended that this ratio be less than 10(-6) for a combined relative uncertainty of less than 1%. The age limits of the technique are set by the value of the rate constant and individual sample mineralogy. This theoretical framework should help future interlaboratory comparison as well as optimizing instrument design.

  14. Surface-exposure ages of Front Range moraines that may have formed during the Younger Dryas, 8.2 cal ka, and Little Ice Age events

    USGS Publications Warehouse

    Benson, L.; Madole, R.; Kubik, P.; McDonald, R.

    2007-01-01

    Surface-exposure (10Be) ages have been obtained on boulders from three post-Pinedale end-moraine complexes in the Front Range, Colorado. Boulder rounding appears related to the cirque-to-moraine transport distance at each site with subrounded boulders being typical of the 2-km-long Chicago Lakes Glacier, subangular boulders being typical of the 1-km-long Butler Gulch Glacier, and angular boulders being typical of the few-hundred-m-long Isabelle Glacier. Surface-exposure ages of angular boulders from the Isabelle Glacier moraine, which formed during the Little Ice Age (LIA) according to previous lichenometric dating, indicate cosmogenic inheritance values ranging from 0 to ???3.0 10Be ka.11Surface-exposure ages in this paper are labeled 10Be; radiocarbon ages are labeled 14C ka, calendar and calibrated radiocarbon ages are labeled cal ka, and layer-based ice-core ages are labeled ka. 14C ages, calibrated 14C ages, and ice core ages are given relative to AD 1950, whereas 10Be ages are given relative to the sampling date. Radiocarbon ages were calibrated using CALIB 5.01 and the INTCAL04 data base Stuiver et al. (2005). Ages estimated using CALIB 5.01 are shown in terms of their 1-sigma range. Subangular boulders from the Butler Gulch end moraine yielded surface-exposure ages ranging from 5 to 10.2 10Be ka. We suggest that this moraine was deposited during the 8.2 cal ka event, which has been associated with outburst floods from Lake Agassiz and Lake Ojibway, and that the large age range associated with the Butler Gulch end moraine is caused by cosmogenic shielding of and(or) spalling from boulders that have ages in the younger part of the range and by cosmogenic inheritance in boulders that have ages in the older part of the range. The surface-exposure ages of eight of nine subrounded boulders from the Chicago Lakes area fall within the 13.0-11.7 10Be ka age range, and appear to have been deposited during the Younger Dryas interval. The general lack of inheritance in

  15. Age, Stratigraphy, and Correlations of the Late Neogene Purisima Formation, Central California Coast Ranges

    USGS Publications Warehouse

    Powell, Charles L.; Barron, John A.; Sarna-Wojcicki, Andrei M.; Clark, Joseph C.; Perry, Frank A.; Brabb, Earl E.; Fleck, Robert J.

    2007-01-01

    The Purisima Formation is an important upper Miocene and Pliocene stratigraphic unit in central California, cropping out from the coast at Point Reyes north of San Francisco to more extensive exposures in the Santa Cruz Mountains to the south. The fine-grained rocks in the lower parts of the Purisima Formation record a latest Miocene transgressive event, whereas the middle and upper parts of the formation consist of increasingly clastic-rich siltstones and sandstones resulting from uplift of adjacent coastal regions and the Sierra Nevada during Pliocene transgressive and regressive sea-level events. Exposures of the Purisima occur in three different, fault-bounded, structural blocks - the Santa Cruz, Pigeon Point, and Point Reyes tectonic blocks - that complicate correlations and regional age assignments. We summarize and compare published and new biostratigraphic and geochronologic data for various exposures of the Purisima Formation on the basis of mollusks, diatoms, radiometric dating, magnetostratigraphy, tephrochronology, and strontium isotope dating. On the basis of these data, we conclude that the Purisima Formation ranges in age from the latest Miocene (about 7 Ma) to the late Pliocene (about 2.6 Ma). The Purisima Formation of Santa Cruz County, exposed in the sea cliffs from Santa Cruz to Rio del Mar, is here designated a supplementary reference section because it is the most complete and well studied Purisima section in central California.

  16. Short versus Long Gonadotropin-Releasing Hormone Analogue Suppression Protocols in IVF/ICSI Cycles in Patients of Various Age Ranges

    PubMed Central

    Li, Yubin; Xu, Yanwen; Zhou, Canquan

    2015-01-01

    Objective To compare the two GnRH-a protocols (long GnRH-a protocol and short GnRH-a protocol) for ovarian stimulation in IVF/ICSI cycles in patients of various age ranges. Methods A total of 5662 IVF-ET/ICSI cycles from 2010 to 2013 were retrospectively identified. The cycles were divided into two groups: a long protocol group and short protocol group. In each group, the patients were divided into four age ranges: <31 years, 31 to 35 years, 36 to 40 years, and >40 years. The duration of stimulation, total dose of Gn, implantation rate and pregnancy rate were compared. Results The total dose of Gn was significantly higher, and the duration of stimulation was significantly longer, in the long protocol group than in the short protocol group for all age ranges (P<0.05). If the patients were of the same age range, the number of oocytes retrieved, MII oocytes, and high-quality embryos in the long protocol group were all significantly greater than those in the short protocol group (P<0.05). In the long protocol group, the clinical pregnancy rates of the four age ranges were 52.76%, 44.33%, 36.15% and 13.33%, respectively, which were significantly higher than those in the short protocol group (33.33%, 24.58%, 22.49% and 8.72%, respectively; P<0.05). The same trend was also found in the implantation rates of the four age ranges. As the age increased, the clinical pregnancy and implantation rates, as well as the number of oocytes retrieved, MII oocytes, and high-quality embryos, of the long protocol group significantly decreased (P<0.05). Conclusions Our study demonstrated that regardless of patient age, the long protocol was superior to the short protocol in terms of the number of retrieved oocytes, as well as the implantation and pregnancy rates. PMID:26208150

  17. Plutonic rocks of Jurassic age in the Alaska-Aleutian Range batholith: chemical variation and polarity.

    USGS Publications Warehouse

    Reed, B.I.; Miesch, A.T.; Lanphere, M.A.

    1983-01-01

    Plutonic rocks of Jurassic age exposed on the Pacific side of this batholith form a compositionally continuous calc-alkaline suite that ranges from hornblende gabbro to quartz monzonite. Tonalite and quartz diorite are the dominant rock types. Trend-surface analysis of 102 samples indicates that the direction of slope of the trend is approximately normal to the Jurassic magmatic arc. K2O and SiO2 increase towards the E-SE and the other oxides towards the W-NW. If the chemical trends reflect the approximate geometry of a palaeo-subduction zone, the polarity of the Jurassic magmatic arc is to the NW, i.e. subduction was directed towards the SE. Thus the palaeo-subduction zone is on the opposite side of the arc from the position that has generally been assumed, indicating that the Jurassic plutonic rocks were not generated in response to classical Andean-type convergent plate margins. The magmatic arc may have been formed in an intra-ocean environment and subsequently has been rafted northwards and accreted to this part of the N Pacific rim during the late Mesozoic. Middle and Upper Jurassic clastics underlying Cook Inlet to the SE and derived from the magmatic arc are classified as back-arc deposits, rather than as an arc-trench gap sequence.-L.C.H.

  18. Depositional settings, correlation, and age carboniferous rocks in the western Brooks Range, Alaska

    USGS Publications Warehouse

    Dumoulin, J.A.; Harris, A.G.; Blome, C.D.; Young, L.E.

    2004-01-01

    The Kuna Formation (Lisburne Group) in northwest Alaska hosts the Red Dog and other Zn-Pb-Ag massive sulfide deposits in the Red Dog district. New studies of the sedimentology and paleontology of the Lisburne Group constrain the setting, age, and thermal history of these deposits. In the western and west-central Brooks Range, the Lisburne Group includes both deep- and shallow-water sedimentary facies and local volcanic rocks that are exposed in a series of thrust sheets or allochthons. Deep-water facies in the Red Dog area (i.e., the Kuna Formation and related rocks) are found chiefly in the Endicott Mountains and structurally higher Picnic Creek allochthons. In the Red Dog plate of the Endicott Mountains allochthon, the Kuna consists of at least 122 m of thinly interbedded calcareous shale, calcareous spiculite, and bioclastic supportstone (Kivalina unit) overlain by 30 to 240 m of siliceous shale, mudstone, calcareous radiolarite, and calcareous lithic turbidite (Ikalukrok unit). The Ikalukrok unit in the Red Dog plate hosts all massive sulfide deposits in the area. It is notably carbonaceous, is generally finely laminated, and contains siliceous sponge spicules and radiolarians. The Kuna Formation in the Key Creek plate of the Endicott Mountains allochthon (60-110 m) resembles the Ikalukrok unit but is unmineralized and has thinner carbonate layers that are mainly organic-rich dolostone. Correlative strata in the Picnic Creek allochthon include less shale and mudstone and more carbonate (mostly calcareous spiculite). Conodonts and radiolarians indicate an age range of Osagean to early Chesterian (late Early to Late Mississippian) for the Kuna in the Red Dog area. Sedimentologic, faunal, and geochemical data imply that most of the Kuna formed in slope and basin settings characterized by anoxic or dysoxic bottom water and by local high productivity. Shallow-water facies of th e Lisburne Group in the Red Dog area are present locally in the Endicott Mountains

  19. New U/Pb ages from granite and granite gneiss in the Ruby geanticline and southern Brooks Range, Alaska ( USA).

    USGS Publications Warehouse

    Patton, W.W.; Stern, T.W.; Arth, Joseph G.; Carlson, C.

    1987-01-01

    New U/Pb zircon ages from the Ray Mountains of central Alaska clarify the plutonic history of the Ruby geanticline and support earlier suggestions that the Ruby geanticline and S Brooks Range were once parts of the same tectonostratigraphic terrane. U/Pb zircon ages of 109 to 112 Ma from the Ray Mountains pluton confirm previously reported mid-Cretaceous K/Ar ages and rule out the possibility that the earliest intrusive phase of the pluton is older than mid-Cretaceous K/Ar ages and rule out the possibility that the earliest intrusive phase of the pluton is older than mid- Cretaceous. New U/Pb zircon ages from 4 granite gneiss samples in the Ray Mountains indicate a Devonian protolith age of 390+ or -12 Ma and suggest that the Ruby geanticline, like the S Brooks Range, underwent a major plutonic event in mid-Paleozoic time.-Authors

  20. Conclusions. [hydrogen-based energy

    NASA Technical Reports Server (NTRS)

    1975-01-01

    Conclusions are presented according to general areas of technology with some specific examples of research and technology needs identified. These conclusions provide a base for the future development of detailed program plans and identify research needs that are not being given attention or are not being supported at a sufficient level. Emphasis is placed on hydrogen production and use.

  1. Effects of age, replicative lifespan and growth rate of human nucleus pulposus cells on selecting age range for cell-based biological therapies for degenerative disc diseases.

    PubMed

    Lee, J S; Lee, S M; Jeong, S W; Sung, Y G; Lee, J H; Kim, K W

    2016-07-01

    Autologous disc cell implantation, growth factors and gene therapy appear to be promising therapies for disc regeneration. Unfortunately, the replicative lifespan and growth kinetics of human nucleus pulposus (NP) cells related to host age are unclear. We investigated the potential relations among age, replicative lifespan and growth rate of NP cells, and determined the age range that is suitable for cell-based biological therapies for degenerative disc diseases. We used NP tissues classified by decade into five age groups: 30s, 40s, 50s, 60s and 70s. The mean cumulative population doubling level (PDL) and population doubling rate (PDR) of NP cells were assessed by decade. We also investigated correlations between cumulative PDL and age, and between PDR and age. The mean cumulative PDL and PDR decreased significantly in patients in their 60s. The mean cumulative PDL and PDR in the younger groups (30s, 40s and 50s) were significantly higher than those in the older groups (60s and 70s). There also were significant negative correlations between cumulative PDL and age, and between PDR and age. We found that the replicative lifespan and growth rate of human NP cells decreased with age. The replicative potential of NP cells decreased significantly in patients 60 years old and older. Young individuals less than 60 years old may be suitable candidates for NP cell-based biological therapies for treating degenerative disc diseases.

  2. K-Ar ages of allochthonous mafic and ultramafic complexes and their metamorphic aureoles, Western Brooks Range, Alaska

    SciTech Connect

    Boak, J.L.; Turner, D.L.; Wallace, W.K.; Moore, T.E.

    1985-04-01

    New K-Ar ages from allochthonous mafic and ultramafic complexes of the western Brooks Range (Brooks Range ophiolite) show that igneous rocks yielded ages nearly identical to those of underlying metamorphic aureole rocks. Dated rocks of the Misheguk igneous sequence from Tumit Creek consist of (1) hornblende gabbro with minor greenschist and lower grade alteration, hornblende age 147.2 +/- 4.4 Ma; and (2) hornblende-bearing diorite, also slightly altered, age 155.8 +/- 4.7 Ma. Both samples come from presumed higher levels of the Misheguk sequence. Dated samples of metamorphic aureole rocks come from outcrops near Kismilot Creek and lie structurally beneath the Iyikrok Mountain peridotite body. The rocks consist of amphibolite and garnet-bearing biotite-hornblende gneiss considered to be metamorphosed Copter igneous sequence and related sedimentary rocks. Hornblende ages are 154.2 +/- 4.6 Ma and 153.2 +/- 4.6 Ma. metamorphism is clearly related to the structurally overlying perioditite, as the degree of alteration decreases downward. The authors suggest that the K-Ar ages of these rocks represent the effects of thermal metamorphism post-dating igneous crystallization, and are related to tectonic emplacement of the complex. Earlier K-Ar data on igneous rocks give similar ages and have been interpreted as reflecting tectonothermal events. The age of igneous crystallization of the mafic and ultramafic rocks of the Misheguk igneous sequence remains uncertain.

  3. 40Ar 39Ar Ages and tectonic setting of ophiolite from the Neyriz area, southeast Zagros Range, Iran

    USGS Publications Warehouse

    Lanphere, M.A.; Pamic, J.

    1983-01-01

    An ophiolite, considered to be an allochthonous fragment of Tethyan oceanic crust and mantle, crops out near Neyriz in the Zagros Range, Iran. 40Ar 39Ar ages ranging from 76.8 ?? 23.8 Ma to 105 ?? 23.3 Ma were measured on hornblende from five samples of plagiogranite and diabase from the ophiolite. The most precise ages are 85.9 ?? 3.8 Ma for a diabase and 83.6 ?? 8.4 Ma for a plagiogranite. The weighted mean age of hornblende from the five samples is 87.5 ?? 7.2 Ma which indicates that the igneous part of the Neyriz ophiolite formed during the early part of the Late Cretaceous. Pargasite from amphibolite below peridotite of the Neyriz ophiolite has a 40Ar 39Ar age of 94.9 ?? 7.6 Ma. The pargasite age agrees within analytical uncertainty with the ages measured on diabase and plagiogranite. Comparable ages have been measured on igneous rocks from the Samail ophiolite of Oman and on amphibolite below peridotite of the Samail ophiolite. ?? 1983.

  4. Conclusions and Recommendations. Chapter 37

    NASA Technical Reports Server (NTRS)

    Lamar, John E.; Hummel, Dietrich

    2009-01-01

    This chapter provides a brief wrap-up of the task group report and focuses on the overall conclusions and recommendations for future work for the CAWAPI and VFE-2 facets beyond the task group. The overall conclusion is that the Technology Readiness Level (TRL) of CFD solvers has been improved in predicting the flow-physics of vortex-dominated flows during the work of the task group, by having flight and wind-tunnel data available for comparison. Moreover, like all good scientific studies, this task group has identified flight conditions on the F-16XL airplane or wind-tunnel test conditions for a specific leading-edge radius on the 65 delta-wing model where the TRL still needs to be increased.

  5. The exclusion of a significant range of ages in a massive star cluster.

    PubMed

    Li, Chengyuan; de Grijs, Richard; Deng, Licai

    2014-12-18

    Stars spend most of their lifetimes on the main sequence in the Hertzsprung-Russell diagram. The extended main-sequence turn-off regions--containing stars leaving the main sequence after having spent all of the hydrogen in their cores--found in massive (more than a few tens of thousands of solar masses), intermediate-age (about one to three billion years old) star clusters are usually interpreted as evidence of internal age spreads of more than 300 million years, although young clusters are thought to quickly lose any remaining star-forming fuel following a period of rapid gas expulsion on timescales of order 10(7) years. Here we report, on the basis of a combination of high-resolution imaging observations and theoretical modelling, that the stars beyond the main sequence in the two-billion-year-old cluster NGC 1651, characterized by a mass of about 1.7 × 10(5) solar masses, can be explained only by a single-age stellar population, even though the cluster has a clearly extended main-sequence turn-off region. The most plausible explanation for the existence of such extended regions invokes a population of rapidly rotating stars, although the secondary effects of the prolonged stellar lifetimes associated with such a stellar population mixture are as yet poorly understood. From preliminary analysis of previously obtained data, we find that similar morphologies are apparent in the Hertzsprung-Russell diagrams of at least five additional intermediate-age star clusters, suggesting that an extended main-sequence turn-off region does not necessarily imply the presence of a significant internal age dispersion. PMID:25519133

  6. The exclusion of a significant range of ages in a massive star cluster.

    PubMed

    Li, Chengyuan; de Grijs, Richard; Deng, Licai

    2014-12-18

    Stars spend most of their lifetimes on the main sequence in the Hertzsprung-Russell diagram. The extended main-sequence turn-off regions--containing stars leaving the main sequence after having spent all of the hydrogen in their cores--found in massive (more than a few tens of thousands of solar masses), intermediate-age (about one to three billion years old) star clusters are usually interpreted as evidence of internal age spreads of more than 300 million years, although young clusters are thought to quickly lose any remaining star-forming fuel following a period of rapid gas expulsion on timescales of order 10(7) years. Here we report, on the basis of a combination of high-resolution imaging observations and theoretical modelling, that the stars beyond the main sequence in the two-billion-year-old cluster NGC 1651, characterized by a mass of about 1.7 × 10(5) solar masses, can be explained only by a single-age stellar population, even though the cluster has a clearly extended main-sequence turn-off region. The most plausible explanation for the existence of such extended regions invokes a population of rapidly rotating stars, although the secondary effects of the prolonged stellar lifetimes associated with such a stellar population mixture are as yet poorly understood. From preliminary analysis of previously obtained data, we find that similar morphologies are apparent in the Hertzsprung-Russell diagrams of at least five additional intermediate-age star clusters, suggesting that an extended main-sequence turn-off region does not necessarily imply the presence of a significant internal age dispersion.

  7. Conclusive exclusion of quantum states

    NASA Astrophysics Data System (ADS)

    Bandyopadhyay, Somshubhro; Jain, Rahul; Oppenheim, Jonathan; Perry, Christopher

    2014-02-01

    In the task of quantum state exclusion, we consider a quantum system prepared in a state chosen from a known set. The aim is to perform a measurement on the system which can conclusively rule that a subset of the possible preparation procedures cannot have taken place. We ask what conditions the set of states must obey in order for this to be possible and how well we can complete the task when it is not. The task of quantum state discrimination forms a subclass of this set of problems. Within this paper, we formulate the general problem as a semidefinite program (SDP), enabling us to derive sufficient and necessary conditions for a measurement to be optimal. Furthermore, we obtain a necessary condition on the set of states for exclusion to be achievable with certainty, and we give a construction for a lower bound on the probability of error. This task of conclusively excluding states has gained importance in the context of the foundations of quantum mechanics due to a result from Pusey, Barrett, and Rudolph (PBR). Motivated by this, we use our SDP to derive a bound on how well a class of hidden variable models can perform at a particular task, proving an analog of Tsirelson's bound for the PBR experiment and the optimality of a measurement given by PBR in the process. We also introduce variations of conclusive exclusion, including unambiguous state exclusion, and state exclusion with worst-case error.

  8. Cosmogenic exposure-age chronologies of Pinedale and Bull Lake glaciations in greater Yellowstone and the Teton Range, USA

    USGS Publications Warehouse

    Licciardi, J.M.; Pierce, K.L.

    2008-01-01

    We have obtained 69 new cosmogenic 10Be surface exposure ages from boulders on moraines deposited by glaciers of the greater Yellowstone glacial system and Teton Range during the middle and late Pleistocene. These new data, combined with 43 previously obtained 3He and 10Be ages from deposits of the northern Yellowstone outlet glacier, establish a high-resolution chronology for the Yellowstone-Teton mountain glacier complexes. Boulders deposited at the southern limit of the penultimate ice advance of the Yellowstone glacial system yield a mean age of 136??13 10Be ka and oldest ages of ???151-157 10Be ka. These ages support a correlation with the Bull Lake of West Yellowstone, with the type Bull Lake of the Wind River Range, and with Marine Isotope Stage (MIS) 6. End moraines marking the maximum Pinedale positions of outlet glaciers around the periphery of the Yellowstone glacial system range in age from 18.8??0.9 to 16.5??1.4 10Be ka, and possibly as young as 14.6??0.7 10Be ka, suggesting differences in response times of the various ice-cap source regions. Moreover, all dated Pinedale terminal moraines in the greater Yellowstone glacial system post-date the Pinedale maximum in the Wind River Range by ???4-6 kyr, indicating a significant phase relationship between glacial maxima in these adjacent ranges. Boulders on the outermost set and an inner set of Pinedale end moraines enclosing Jenny Lake on the eastern Teton front yield mean ages of 14.6??0.7 and 13.5??1.1 10Be ka, respectively. The outer Jenny Lake moraines are partially buried by outwash from ice on the Yellowstone Plateau, hence their age indicates a major standstill of an expanded valley glacier in the Teton Range prior to the Younger Dryas, followed closely by deglaciation of the Yellowstone Plateau. These new glacial chronologies are indicative of spatially variable regional climate forcing and temporally complex patterns of glacier responses in this region of the Rocky Mountains during the Pleistocene

  9. Thermoluminescence dating of sediments: a re-extension of age range for loess

    SciTech Connect

    Johnson, R.J.; Stipp, J.J.; Wintle, A.G.; Tamers, M.A.

    1985-01-01

    Thermoluminescence (TL) dating of wind blown minerals provides a technique whereby non-carbonaceous sediments could be dated to several hundred thousand years. Two recent reports, however, indicate age underestimates on feldspar in some European loesses older than 50 ka, the effect increasing in severity with age. Suggested causes include decay of luminescence centers, or does dependent sensitivity changes. Data presented in this paper do not support these limitations or explanations. TL provides 3 separate techniques of dating sediments, which, when used together, prove to be efficient internal cross checks for mineralogical anomalies or inconsistencies created by any of the individual methods. In the authors studies each sample was dated by all 3 methods whereas the Europeans analyses employed only the Regeneration technique. This work presents results from loess sections in Mississippi, Illinois and Alaska. These show excellent internal consistency, and consistency with both independent dating methods and stratigraphy, with 2 exceptions. Both exceptions were by the Regen technique giving age underestimates up to 30%. The underestimates were found to be caused by a change in mineral sensitivity resulting from the Regen requirements of strong laboratory light-bleaching followed by irradiations. A simple method to test and correct for this condition is presented. TL thus appears to remain a powerful and increasingly flexible method of sediment dating.

  10. Fission track ages of detrital zircons from sandstones of the Umpqua Group and Tyee Formation, Oregon coast range

    SciTech Connect

    Vance, J.A. . Dept. of Geological Sciences); Brandon, M.T. . Dept. of Geology and Geophysics)

    1993-04-01

    Detrital zircons from Paleogene sandstones of the Umpqua Group (UG) and the Tyee Fm (TF) yield contrasting FT age patterns which distinguish these two units and cast new light on their regional extent, correlation and provenance. In the Roseburg (Rg) area of the southern Oregon Coast Range, where most widely exposed, the UG consists of continental and marine clastic beds which overlie submarine lavas of the Coast Range Basalt. K-Ar And Ar-Ar dating of the basement basalts shows a younging trend from about 62 Ma at Rg at the south to 56 Ma at Siletz River and 53 Ma at Tillamook to the north. Detrital zircons from the Rg area are characterized by old FT ages. Of 192 grains dated, 90% are older than 90 Ma; the median age is 129 Ma. A diorite cobble from an UG conglomerate gave a zircon FT age of 105 Ma. These ages point to a source in the Jurassic plutons in the Klamath Mountains nearby to the south. The authors have determined FT cooling ages of 110 and 120 Ma for zircons from the Mt. Ashland and Grants Pass plutons. Continental and shallow marine clastic strata of the TF overly the UG beds west of Rg. The UG is not widely exposed north of Rg where it thins and pinches out above the Coast Range Basalt and is overlain by a northern turbidite facies of the TF. Three TF sandstones from the latitude of Rg and three others from west and south of Corvallis yielded distinctive and identical zircon FT age patterns characterized by young ages. Of 335 zircons dated, 80% are younger than 90 Ma; the median age is 61 Ma. This maximum age is very close to that of the overlying Tillamook and Fisher Fms. The flood of detrital zircons with young FT ages in the TF marks the abrupt change from a nearby Klamath source for the UG beds to a distant, easterly TF source in a recently uplifted plutonic-metamorphic terrane.

  11. Isotopes and ages in the northern Peninsular Ranges batholith, southern California

    USGS Publications Warehouse

    Kistler, Ronald W.; Wooden, Joseph L.; Morton, Douglas M.

    2003-01-01

    Strontium, oxygen and lead isotopic and rubidium-strontium geochronologic studies have been completed on Cretaceous and Jurassic (?) granitic rock samples from the northern Peninsular Ranges batholith in southern California. Many of these samples were collected systematically and studied chemically by A. K. Baird and colleagues (Baird and others, 1979). The distribution of these granitic rocks is shown in the Santa Ana, Perris, and San Jacinto Blocks, bounded by the Malibu Coast-Cucamonga, Banning, and San Andreas fault zones, and the Pacific Ocean on the map of the Peninsular Ranges batholith and surrounding area, southern California. The granitic rock names are by Baird and Miesch (1984) who used a modal mineral classification that Bateman and others (1963) used for granitic rocks in the Sierra Nevada batholith. In this classification, granitic rocks have at least 10% quartz. Boundaries between rock types are in terms of the ratio of alkali-feldspar to total feldspar: quartz diorite, 0-10%; granodiorite, 10-35%; quartz monzonite 35-65%; granite >65%. Gabbros have 0-10% quartz. Data for samples investigated are giv in three tables: samples, longitude, latitude, specific gravity and rock type (Table 1); rubidium and strontium data for granitic rocks of the northern Peninsular Ranges batholith, southern California (Table 2); U, Th, Pb concentrations, Pb and Sr initial isotopic compositions, and δ18O permil values for granitic rocks of the northern Peninsular Ranges batholith (table 3).

  12. Gondwanian age dextral transpression and spatial kinematic partitioning within the Heritage Range, Ellsworth Mountains, West Antarctica

    NASA Astrophysics Data System (ADS)

    Curtis, Michael L.

    1997-02-01

    The Ellsworth Mountains, West Antarctica, consist of two mountain ranges; the Sentinel, and Heritage ranges. The more southerly Heritage Range is composed of a lower Paleozoic sedimentary and volcanic rock sequence, deformed during a single major deformation event in the early Mesozoic. This Gondwanian Orogeny possibly resulted from Andean-style convergence along the southern margin of Gondwana, prior to break-up of the super-continent, and the subsequent translation of the Ellsworth Mountains from a position close to the Natal embayment of southern Africa to that of the present day. Rocks of the Heritage Range are intensely folded, with close to tight, upright to inclined folds, plunging gently about a horizontal axis trending NNW-SSE. Locally, folds plunge moderately to subvertical toward the NNW, possessing asymmetries consistent with a dextral sense of shear. Cleavage is generally axial planar displaying downdip and strike-parallel stretching lineations that are frequently associated with domains of reverse, and dextral shear striking parallel to the regional structural grain. The spatial and temporal relationship of fractures developed within these domains as a result of noncoaxial shear, in addition to the progressive incremental strain histories derived from mineral fibres in strain shadows, indicate the contemporaneous nature of these shear domains. Strain analysis of deformed tuffaceous diamictites and oncolithic limestones reveal k-values <1 (mean 0.59) throughout the Heritage Range. The coexistence of strike-parallel dextral, oblique and reverse-shear domains, abrupt reorientation of progressive strain axes, steep cleavage dips, and k-values <1 are all consistent with a dextral transpressive deformation regime, previously unrecognized in the Ellsworth Mountains. A model of highly oblique (pure-shear dominated) transpression, associated with efficient spatial partitioning of the strike-slip component of shear is proposed to describe the structural

  13. Characterization of polymers in the glass transition range: Time-temperature and time-aging time superposition in polycarbonate

    SciTech Connect

    Pesce, J.J.; Niemiec, J.M.; Chiang, M.Y.

    1995-12-31

    Here we present time-temperature and time-aging time superposition data for a commercial grade polycarbonate. The data reduction is performed for dynamic-mechanical data obtained in torsion over a range of temperatures from 103.6 to 144.5{degrees}C and aging times to 16 h. For time-temperature superposition the results show the deviation of the sub-T{sub g} response from the WTF equation. Two response regimes are observed: at temperatures far below T{sub g} the log(a{sub T}) is linear in T, followed by a transition towards the WLF behavior as T{sub g} is approached. The temperature at which the behavior changes from a linear dependence of log(aT) on T to the transition-type behavior is found to depend on the aging time. This temperature decreases as aging time increases. The time-aging time response is found to behave in a normal way. At temperatures far below T{sub g} the log(a{sub te}) vs log(t{sub e}) is constant and has a slope somewhat less than unity. However, nearer to T{sub g} the slope decreases and there is a second regime in which the aging virtually ceases. In this polycarbonate, above 136.9{degrees}C, no aging is observed.

  14. Procrastination, Distress and Life Satisfaction across the Age Range - A German Representative Community Study.

    PubMed

    Beutel, Manfred E; Klein, Eva M; Aufenanger, Stefan; Brähler, Elmar; Dreier, Michael; Müller, Kai W; Quiring, Oliver; Reinecke, Leonard; Schmutzer, Gabriele; Stark, Birgit; Wölfling, Klaus

    2016-01-01

    Addressing the lack of population-based data the purpose of this representative study was to assess procrastination and its associations with distress and life satisfaction across the life span. A representative German community sample (1,350 women; 1,177 men) between the ages of 14 and 95 years was examined by the short form of the General Procrastination Scale (GPS-K; 1) and standardized scales of perceived stress, depression, anxiety, fatigue and life satisfaction. As hypothesized, procrastination was highest in the youngest cohort (14-29 years). Only in the youngest and most procrastinating cohort (aged 14 to 29 years), men procrastinated more than women. As we had further hypothesized, procrastination was consistently associated with higher stress, more depression, anxiety, fatigue and reduced satisfaction across life domains, especially regarding work and income. Associations were also found with lack of a partnership and unemployment. Findings are discussed with regard to potential developmental and cohort effects. While procrastination appears to be a pervasive indicator for maladjustment, longitudinal analyses in high-risk samples (e.g. late adolescence, unemployment) are needed to identify means and mechanisms of procrastinating.

  15. Procrastination, Distress and Life Satisfaction across the Age Range – A German Representative Community Study

    PubMed Central

    2016-01-01

    Addressing the lack of population-based data the purpose of this representative study was to assess procrastination and its associations with distress and life satisfaction across the life span. A representative German community sample (1,350 women; 1,177 men) between the ages of 14 and 95 years was examined by the short form of the General Procrastination Scale (GPS-K; 1) and standardized scales of perceived stress, depression, anxiety, fatigue and life satisfaction. As hypothesized, procrastination was highest in the youngest cohort (14–29 years). Only in the youngest and most procrastinating cohort (aged 14 to 29 years), men procrastinated more than women. As we had further hypothesized, procrastination was consistently associated with higher stress, more depression, anxiety, fatigue and reduced satisfaction across life domains, especially regarding work and income. Associations were also found with lack of a partnership and unemployment. Findings are discussed with regard to potential developmental and cohort effects. While procrastination appears to be a pervasive indicator for maladjustment, longitudinal analyses in high-risk samples (e.g. late adolescence, unemployment) are needed to identify means and mechanisms of procrastinating. PMID:26871572

  16. Procrastination, Distress and Life Satisfaction across the Age Range - A German Representative Community Study.

    PubMed

    Beutel, Manfred E; Klein, Eva M; Aufenanger, Stefan; Brähler, Elmar; Dreier, Michael; Müller, Kai W; Quiring, Oliver; Reinecke, Leonard; Schmutzer, Gabriele; Stark, Birgit; Wölfling, Klaus

    2016-01-01

    Addressing the lack of population-based data the purpose of this representative study was to assess procrastination and its associations with distress and life satisfaction across the life span. A representative German community sample (1,350 women; 1,177 men) between the ages of 14 and 95 years was examined by the short form of the General Procrastination Scale (GPS-K; 1) and standardized scales of perceived stress, depression, anxiety, fatigue and life satisfaction. As hypothesized, procrastination was highest in the youngest cohort (14-29 years). Only in the youngest and most procrastinating cohort (aged 14 to 29 years), men procrastinated more than women. As we had further hypothesized, procrastination was consistently associated with higher stress, more depression, anxiety, fatigue and reduced satisfaction across life domains, especially regarding work and income. Associations were also found with lack of a partnership and unemployment. Findings are discussed with regard to potential developmental and cohort effects. While procrastination appears to be a pervasive indicator for maladjustment, longitudinal analyses in high-risk samples (e.g. late adolescence, unemployment) are needed to identify means and mechanisms of procrastinating. PMID:26871572

  17. OASDI (Old-Age and Survivors Insurance): fiscal basis and long-range cost projections.

    PubMed

    Robertson, A H

    1977-01-01

    A thorough understanding of the financing structure of social security is a prerequisite to serious discussion of the financial condition of the program. In examining this structure, it becomes clear that the most important test of the program's financial soundness is whether expected future income to the funds equals expected future expenditures. Short-range and long-range cost estimates indicate that this condition does not exist and that an actual deficit of 7.96 percent of taxable payroll, equivalent to $4.3 trillion, needs to be eliminated--half of it perhaps by stabilizing benefits at current levels in relation to preretirement earnings. In addition, an unfunded accrued liability of $3.1 trillion exists, although there is no indication that this liability needs to be funded. PMID:847590

  18. Effects of age on cerebrospinal fluid oxytocin levels in free-ranging adult female and infant rhesus macaques

    PubMed Central

    Parker, Karen J.; Hoffman, Christy L.; Hyde, Shellie A.; Cummings, Carl S.; Maestripieri, Dario

    2013-01-01

    There is growing interest in studying oxytocin biology in the context of social functioning in human and non-human primates. Studies of human subjects are typically restricted to peripheral oxytocin assessments because opportunities to collect cerebrospinal fluid (CSF) are rare. A few studies have examined CSF oxytocin levels in captive adult primates, but none to our knowledge have been conducted under free-ranging conditions and inclusive of young infants. The main goal of the present study was to establish feasibility of quantifying CSF oxytocin levels in free-ranging adult female and infant rhesus monkeys living on the island of Cayo Santiago, Puerto Rico. CSF oxytocin levels were examined in relation to individuals’ demographic and reproductive characteristics, as well as in relation to plasma cortisol levels. CSF oxytocin concentrations ranged from 36.02 to 134.41 pg/ml in adult females (ages 7–26 years; N = 31) and 35.94 to 77.3 pg/ml in infants (ages 38–134 days; N = 17). CSF oxytocin levels were positively correlated with adult female age and negatively correlated with infant age. The former correlation was driven by reproductive status. CSF oxytocin levels were unrelated to dominance rank or plasma cortisol levels. In contrast to a previous study of plasma oxytocin concentrations in this population, CSF oxytocin levels did not differ significantly between lactating and non-lactating females. In summary, these findings: 1) provide feasibility data for examining CSF oxytocin biology in free-ranging nonhuman primates and 2) indicate that CSF oxytocin levels may be a biomarker of age-related central nervous system changes across lifespan development. Although our study did not report significant associations between CSF oxytocin levels and socially-relevant demographic variables, the relationships between CSF oxytocin levels and assessments of social functioning warrant future investigation. PMID:20528088

  19. [SENTIERI Project: discussion and conclusions].

    PubMed

    Pirastu, Roberta; Ricci, Paolo; Comba, Pietro; Bianchi, Fabrizio; Biggeri, Annibale; Conti, Susanna; Fazzo, Lucia; Forastiere, Francesco; Iavarone, Ivano; Martuzzi, Marco; Musmeci, Loredana; Pasetto, Roberto; Zona, Amerigo; Crocetti, Emanuele

    2014-01-01

    showing the increase, considering latency and the length of the observation period. Of further interest are results relating to diseases of the urinary tract such as kidney failure in the NPCSs of Basso bacino del fiume Chienti, Taranto, Milazzo and Priolo. Overall, the results discussed above are consistent with the previous findings pertaining to mortality for 1995-2002. The present analysis also introduces a new element - the study of cancer incidence and hospital discharges - which can tell us a great deal about diseases with high survival rates or non lethal ones. The first is the case of thyroid cancer, which presents increases in both databases and for both genders in a number of NPCSs (Brescia-Caffaro, Laghi di Mantova, Milazzo, Sassuolo- Scandiano and Taranto). The study of cancer incidence and hospital discharges also revealed cancer excesses for melanoma, breast cancer and non Hodgkin lymphoma in Brescia-Caffaro NPCS where PCBs (Polychlorinated biphenyl) are the site's main pollutant. PCBs, according to the 2013 evaluation of the International Agency for Research on Cancer, are ascertained human carcinogens for melanoma and probable carcinogens for breast cancer and non-Hodgkin lymphoma. The results pertaining to cancer incidence in the 17 NPCSs can also be presented using rankings by area or disease analyzed by a multivariate hierarchical Bayesian model. These rankings reveal an overlapping of credibility intervals, such that it is not possible to speak of a limited number of cancer sites or of certain NPCSs as being particularly affected. Every NPCS, therefore, must be considered individually and ordering them by ranking of cancer incidence wouldn't be appropriate. Data collected concerning some of the NPCSs in the context of the SENTIERI Project is so conclusive that remediation measures can immediately be put in place. This is the case in the Biancavilla and Brescia-Caffaro NPCSs. A similar conclusion can be drawn for complex locations such as Taranto

  20. Age constraints for Paleoproterozoic glaciation in the Lake Superior Region: Detrital zircon and hydrothermal xenotime ages for the Chocolay Group, Marquette Range Supergroup

    USGS Publications Warehouse

    Vallini, D.A.; Cannon, W.F.; Schulz, K.J.

    2006-01-01

    A geochronological study of the Chocolay Group at the base of the Paleoproterozoic Marquette Range Supergroup in Michigan, Lake Superior Region, is attempted for the first time, Age data from detrital zircon grains and hydrothermal xenotime from the basal glaciogenic formation, the Enchantment Lake Formation, and the stratigraphically higher Sturgeon Quartzite and its equivalent, the Sunday Quartzite, provide maximum and minimum age constraints for the Chocolay Group. The youngest detrital zircon population in the Enchantment Lake Formation is 2317 ?? 6 Ma; in the Sturgeon Quartzite, it is 2306 ?? 9 Ma, and in the Sunday Quartzite, it is 2647 ?? 5 Ma. The oldest hydrothermal xenotime age in the Enchantment Lake Formation is 2133 ?? 11 Ma; in the Sturgeon Quartzite, it is 2115 ?? 5 Ma, and in the Sunday Quartzite, it is 2207 ?? 5 Ma. The radiometric age data in this study implies the depositional age of the Chocolay Group is constrained to ???2.3-2.2 Ga, which proves its correlation with part of the Huronian Supergroup in the Lake Huron Region, Ontario, and reveals the unconformity that separates the Chocolay Group from the overlying Menominee Group is up to 325 million years in duration. The source(s) of the ??? 2.3 Ga detrital zircon populations in the Enchantment Lake Formation and Sturgeon Quartzite remains an enigma because no known rock units of this age are known in the Michigan area. It is speculated that once widespread volcano-sedimentary cover sequences in Michigan were removed or concealed prior to Chocolay Group deposition. The hydrothermal xenotime ages probably reflect basinal hydrothermal fluid flow associated with the period of extension involving rifting and major dyke formation, that affected the North American provinces between 2.2 and 2.1 Ga. ?? 2006 NRC Canada.

  1. Haematological profile on non-lactating Mediterranean buffaloes (Bubalus bubalis) ranging in age from 24 months to 14 years.

    PubMed

    Ciaramella, P; Corona, M; Ambrosio, R; Consalvo, F; Persechino, A

    2005-08-01

    Haematological studies were performed on 100 clinically normal non-lactating Mediterranean buffalo species ranging in age from 24 months to 14 years, to determinate the range of normal haematological values for this ruminant species. The animals were divided in 5 groups according to age: Group I, 2-3 years old which had never calved, Group II, 3-4 years old (primipara buffaloes), Group III, 5-7 years old, Group IV 8-10 years old and Group V over 10 years of age. All the haematological values obtained were comparable with the normal values found in adult cattle, and similar to those reported in Indian water buffalo species. The heifer buffalo showed an higher values for packed cell volume (PCV) compared with the older animals, but lower values for mean corpuscular haemoglobin concentration (MCHC) and mean corpuscular haemoglobin (MCH) (P 0.01). In animals above 8 years of age, the white cell count was lower with a significant reduction in absolute values of lymphocytes (P 0.01). Higher absolute values of eosinophils levels was found in the group V (P 0.01). PMID:15894028

  2. The child's conception of food: differentiation of categories of rejected substances in the 16 months to 5 year age range.

    PubMed

    Rozin, P; Hammer, L; Oster, H; Horowitz, T; Marmora, V

    1986-06-01

    Children (N = 54) ranging in age from one year four months to five years were offered over 30 items to eat. The items included normal adult foods and exemplars of different adult rejection categories: disgust (e.g. grasshopper, hair), danger (liquid dish soap), inappropriate (e.g. paper, leaf) and unacceptable combinations (e.g. ketchup and cookie). We report a high to moderate level of acceptance (item put into mouth) of substances from all of these categories in the youngest children. Acceptance of disgusting and dangerous substances decreases with increasing age, while acceptance of inappropriate substances remains at moderate levels across the age range studied. Although the youngest children accepted more disgust items, the majority rejected most of the disgust choices. Almost all children at all ages tested accept combinations of foods which, although individually accepted by adults, are rejected in combination. No significant differences were observed between 'normal' children and those with a history of toxin ingestion, although there was a tendency of ingesters to accept more inedible items. In general, the results suggest that a major feature of the development of food selection is learning what not to eat. PMID:3740830

  3. Haematological profile on non-lactating Mediterranean buffaloes (Bubalus bubalis) ranging in age from 24 months to 14 years.

    PubMed

    Ciaramella, P; Corona, M; Ambrosio, R; Consalvo, F; Persechino, A

    2005-08-01

    Haematological studies were performed on 100 clinically normal non-lactating Mediterranean buffalo species ranging in age from 24 months to 14 years, to determinate the range of normal haematological values for this ruminant species. The animals were divided in 5 groups according to age: Group I, 2-3 years old which had never calved, Group II, 3-4 years old (primipara buffaloes), Group III, 5-7 years old, Group IV 8-10 years old and Group V over 10 years of age. All the haematological values obtained were comparable with the normal values found in adult cattle, and similar to those reported in Indian water buffalo species. The heifer buffalo showed an higher values for packed cell volume (PCV) compared with the older animals, but lower values for mean corpuscular haemoglobin concentration (MCHC) and mean corpuscular haemoglobin (MCH) (P 0.01). In animals above 8 years of age, the white cell count was lower with a significant reduction in absolute values of lymphocytes (P 0.01). Higher absolute values of eosinophils levels was found in the group V (P 0.01).

  4. Significance of zircon U-Pb ages from the Pescadero felsite, west-central California coast ranges

    USGS Publications Warehouse

    McLaughlin, Robert J.; Moore, Diane E.; ,; Martens, UWE C.; Clark, J.C.

    2011-01-01

    Weathered felsite is associated with the late Campanian–Maastrichtian Pigeon Point Formation near Pescadero, California. Poorly exposed, its age and correlation are uncertain. Is it part of the Pigeon Point section west of the San Gregorio–Hosgri fault? Does it rest on Nacimiento block basement? Is it dextrally offset from the Oligocene Cambria Felsite, ∼185 km to the southeast? Why is a calc-alkaline hypabyssal igneous rock intrusive into the outboard accretionary prism? To address these questions, we analyzed 43 oscillatory-zoned zircon crystals from three incipiently recrystallized pumpellyite ± prehnite ± laumontite-bearing Pescadero felsite samples by sensitive high-resolution ion microprobe–reverse geometry (SHRIMP-RG) and laser ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS) techniques. Thirty-three zircons gave late Mesozoic U-Pb ages, with single-grain values ranging from 81 to 167 Ma; ten have pre-Mesozoic, chiefly Proterozoic ages. A group of the four youngest Pescadero zircons yielded an apparent maximum igneous age of ca. 86–90 Ma. Reflecting broad age scatter and presence of partly digested sandstone inclusions, we interpret the rest of the zircons (perhaps all) as xenocrysts. Twenty-three zircons were separated and analyzed from two samples of the similar Cambria Felsite, yielding a unimodal 27 Ma U-Pb age. Clearly, the origin of the Upper Oligocene Cambria Felsite is different from that of the Upper Cretaceous Pescadero felsite; these rocks are not correlated, and do not constrain displacement along the San Gregorio–Hosgri fault. Peak ages differ slightly, but relative probability curves for Mesozoic and pre-Mesozoic Pescadero zircons compare well, for example, with abundant U-Pb age data for detrital zircons from Franciscan metaclastic strata ∼100 km to the east in the Diablo Range–San Francisco Bay area, San Joaquin Great Valley Group turbidites, Upper Cretaceous Nacimiento block Franciscan strata, and Upper

  5. Impact of specific training and competition on myocardial structure and function in different age ranges of male handball players.

    PubMed

    Agrebi, Brahim; Tkatchuk, Vladimir; Hlila, Nawel; Mouelhi, Emna; Belhani, Ali

    2015-01-01

    Handball activity involves cardiac changes and demands a mixture of both eccentric and concentric remodeling within the heart. This study seeks to explore heart performance and cardiac remodeling likely to define cardiac parameters which influence specific performance in male handball players across different age ranges. Forty three players, with a regular training and competitive background in handball separated into three groups aged on average 11.78 ± 0.41 for youth players aka "schools", "elite juniors" 15.99 ± 0.81 and "elite adults" 24.46 ± 2.63 years, underwent echocardiography and ECG examinations. Incremental ergocycle and specific field (SFT) tests have also been conducted. With age and regular training and competition, myocardial remodeling in different age ranges exhibit significant differences in dilatation's parameters between "schools" and "juniors" players, such as the end-diastolic diameter (LVEDD) and the end-systolic diameter of the left ventricle (LVESD), the root of aorta (Ao) and left atrial (LA), while significant increase is observed between "juniors" and "adults" players in the interventricular septum (IVS), the posterior wall thicknesses (PWT) and LV mass index. ECG changes are also noted but NS differences were observed in studied parameters. For incremental maximal test, players demonstrate a significant increase in duration and total work between "schools" and "juniors" and, in total work only, between "juniors" and "seniors". The SFT shows improvement in performance which ranged between 26.17 ± 1.83 sec to 31.23 ± 2.34 sec respectively from "seniors" to "schools". The cross-sectional approach used to compare groups with prior hypothesis that there would be differences in exercise performance and cardiac parameters depending on duration of prior handball practice, leads to point out the early cardiac remodeling within the heart as adaptive change. Prevalence of cardiac chamber dilation with less hypertrophy remodeling was found

  6. The prevalence of Campylobacter amongst a free-range broiler breeder flock was primarily affected by flock age.

    PubMed

    Colles, Frances M; McCarthy, Noel D; Layton, Ruth; Maiden, Martin C J

    2011-01-01

    Campylobacter successfully colonizes broiler chickens, but little is known about the longer term natural history of colonization, since most flocks are slaughtered at an immature age. In this study, the prevalence and genetic diversity of Campylobacter colonizing a single free-range broiler breeder flock was investigated over the course of a year. The age of the flock was the most important factor in determining both the prevalence and diversity of Campylobacter over time. There was no correlation with season, temperature, the amount of rain and sunshine, or the dynamics of colonization amongst geographically and temporally matched broiler flocks. The higher prevalence rates coincided with the age at which broiler chickens are typically slaughtered, but then in the absence of bio-security or other intervention methods, and despite changes in flock management, the prevalence fell to significantly lower levels for the remainder of the study. The genetic diversity of Campylobacter increased as the flock aged, implying that genotypes were accumulated within the flock and may persist for a long time. A better understanding of the ecology of Campylobacter within commercial chicken flocks will allow the design of more effective farm-based interventions.

  7. Reference Ranges and Association of Age and Lifestyle Characteristics with Testosterone, Sex Hormone Binding Globulin, and Luteinizing Hormone among 1166 Western Chinese Men

    PubMed Central

    Shen, Xubo; Wang, Ruifeng; Yu, Na; Shi, Yongjun; Li, Honggang; Xiong, Chengliang; Li, Yan; Zhou, Yuanzhong

    2016-01-01

    Decreased total testosterone (TT) is the recommended metric to identify age-related hypogonadism. However, average TT and the extent to which it varies by age, can vary substantially among different populations. Population-specific reference ranges are needed to understand normal versus abnormal TT levels. Therefore, the goal for this study was to describe androgen concentrations and their correlates among Western Chinese men. We completed a population-based, cross-sectional study including 227 young adults (YA) (20–39 years) and 939 older adults (OA) (40–89 years). We measured TT, sex-hormone binding globulin (SHBG), luteinizing hormone (LH), testosterone secreting index (TSI), and calculated free testosterone (cFT). Reference ranges for this population were determined using average YA concentrations. Multivariable regression models were used to predict hormone concentrations adjusting for age, waist-to-height ratio (WHR), marital status, education, occupation, smoking, alcohol, blood glucose, and blood pressure. Among OA, 3.8% had low TT, 15.2% had low cFT, 26.3% had low TSI, 21.6% had high SHBG, and 6.1% had high LH. Average cFT was significantly lower in OA (0.30 nmol/L; standard deviation (SD): 0.09) versus YA (0.37; SD: 0.11) but TT was not different in OA (16.82 nmol/L; SD: 4.80) versus YA (16.88; SD: 5.29). In adjusted models increasing age was significantly associated with increased SHBG or LH, and decreased cFT or TSI; however, TT was not significantly associated with age (β = 0.02 nmol/L; 95% confidence interval (CI): -0.01, 0.04). Higher WHR was associated with significantly decreased TT, SHBG, TSI, and LH. The only variable significantly related to cFT was age (β = -0.0033; 95% CI:-0.0037, -0.0028); suggesting that cFT measurements would not be confounded by other lifestyle factors. In conclusion, cFT, but not TT, varies with age in this population, suggesting cFT may be a better potential marker for age-related androgen deficiency than TT among

  8. Impact of specific training and competition on myocardial structure and function in different age ranges of male handball players

    PubMed Central

    Agrebi, Brahim; Tkatchuk, Vladimir; Hlila, Nawel; Mouelhi, Emna; Belhani, Ali

    2015-01-01

    Handball activity involves cardiac changes and demands a mixture of both eccentric and concentric remodeling within the heart. This study seeks to explore heart performance and cardiac remodeling likely to define cardiac parameters which influence specific performance in male handball players across different age ranges. Forty three players, with a regular training and competitive background in handball separated into three groups aged on average 11.78±0.41 for youth players aka “schools”, “elite juniors” 15.99±0.81 and “elite adults” 24.46±2.63 years, underwent echocardiography and ECG examinations. Incremental ergocycle and specific field (SFT) tests have also been conducted. With age and regular training and competition, myocardial remodeling in different age ranges exhibit significant differences in dilatation’s parameters between “schools” and “juniors” players, such as the end-diastolic diameter (LVEDD) and the end-systolic diameter of the left ventricle (LVESD), the root of aorta (Ao) and left atrial (LA), while significant increase is observed between “juniors” and “adults” players in the interventricular septum (IVS), the posterior wall thicknesses (PWT) and LV mass index. ECG changes are also noted but NS differences were observed in studied parameters. For incremental maximal test, players demonstrate a significant increase in duration and total work between “schools” and “juniors” and, in total work only, between “juniors” and “seniors”. The SFT shows improvement in performance which ranged between 26.17±1.83 sec to 31.23±2.34 sec respectively from “seniors” to “schools”. The cross-sectional approach used to compare groups with prior hypothesis that there would be differences in exercise performance and cardiac parameters depending on duration of prior handball practice, leads to point out the early cardiac remodeling within the heart as adaptive change. Prevalence of cardiac chamber dilation

  9. Impact of specific training and competition on myocardial structure and function in different age ranges of male handball players.

    PubMed

    Agrebi, Brahim; Tkatchuk, Vladimir; Hlila, Nawel; Mouelhi, Emna; Belhani, Ali

    2015-01-01

    Handball activity involves cardiac changes and demands a mixture of both eccentric and concentric remodeling within the heart. This study seeks to explore heart performance and cardiac remodeling likely to define cardiac parameters which influence specific performance in male handball players across different age ranges. Forty three players, with a regular training and competitive background in handball separated into three groups aged on average 11.78 ± 0.41 for youth players aka "schools", "elite juniors" 15.99 ± 0.81 and "elite adults" 24.46 ± 2.63 years, underwent echocardiography and ECG examinations. Incremental ergocycle and specific field (SFT) tests have also been conducted. With age and regular training and competition, myocardial remodeling in different age ranges exhibit significant differences in dilatation's parameters between "schools" and "juniors" players, such as the end-diastolic diameter (LVEDD) and the end-systolic diameter of the left ventricle (LVESD), the root of aorta (Ao) and left atrial (LA), while significant increase is observed between "juniors" and "adults" players in the interventricular septum (IVS), the posterior wall thicknesses (PWT) and LV mass index. ECG changes are also noted but NS differences were observed in studied parameters. For incremental maximal test, players demonstrate a significant increase in duration and total work between "schools" and "juniors" and, in total work only, between "juniors" and "seniors". The SFT shows improvement in performance which ranged between 26.17 ± 1.83 sec to 31.23 ± 2.34 sec respectively from "seniors" to "schools". The cross-sectional approach used to compare groups with prior hypothesis that there would be differences in exercise performance and cardiac parameters depending on duration of prior handball practice, leads to point out the early cardiac remodeling within the heart as adaptive change. Prevalence of cardiac chamber dilation with less hypertrophy remodeling was found

  10. Age of the Dawson Arkose, southwestern Air Force Academy, Colorado, and implications for the uplift history of the Front Range

    SciTech Connect

    Kluth, C.F.; Nelson, S.N. )

    1988-01-01

    An angular unconformity within the synorogenic Dawson Arkose (Late Cretaceous-Eocene) is preserved and exposed in areas south of Denver, Colorado, along the eastern side of the Front Range uplift. In the southwestern part of the Air Force Academy, the basal Dawson is concordant with the underlying Laramie and Fox Hills formations and dips 72-84{degree} eastward. Above an intraformational angular unconformity, younger units of the Dawson dip 24{degree}-46{degree} eastward. Smaller angular unconformities (10{degree}{plus minus}), and beds with gradually decreasing dip occur higher in the Dawson section. Rocks above the largest unconformity contain a rich palynomorph assemblage of Late Maestrichtain age. These data indicate that approximately 30{degree}-40{degree}, and possibly as much as approximately 70{degree}, of tilting of the underlying rocks occurred during the Late Maestrichtian (66-70 Ma). It is also possible that approximately 30{degree}-40{degree} of the tilting of the Late Cretaceous rocks occurred between latest Maestrichtian and Eocene (approximately 45 Ma). These results suggest that the transition from a tectonically quiet marine environment to a non-marine, tectonically active condition took place rapidly, probably within a few million years. When combined with published data, the authors study indicates that the Front Range has different tectonic histories on its eastern and its western side, and that the deformation is diachronous along the strike of the eastern side of the Front Range.

  11. Geomagnetic Investigation of Sandstone Dikes of the Colorado Front Range, for Determination of Age and Mode of Emplacement

    NASA Astrophysics Data System (ADS)

    Freedman, D.; Petronis, M. S.; Siddoway, C. S.

    2012-12-01

    In the Colorado Front Range, an array of sandstone dikes has intrigued geologists for over a century (Cross 1894,GSAB, 5, 525). Within their crystalline host, the dikes reach widths >7m and have a lateral extent of 70km along the Ute Pass Fault (UPF). The essential questions of sediment source, emplacement mode, and age of the dikes are unanswered. We present new paleomagnetic, rock magnetic, and anisotropy of magnetic susceptibility (AMS) results used to determine the age and emplacement behavior of the dikes. The eleven dikes selected for magnetic studies have sharp, planar margins, and share the systematic geometry of the NW striking subvertical dike array. They exhibit little or no overprint by brittle fracturing/shear associated with the UPF. Our approach involved the use of paleomagnetic techniques to isolate the characteristic remanent magnetization (ChRM), which we used to limit the age of the dikes' magnetization. Anisotropy of magnetic susceptibility (AMS),arising from alignment of detrital magnetite, serves as a proxy for the orientation of flow during dike emplacement. U-Pb detrital zircon ages, obtained previously, did not provide a useful constraint on emplacement age because the dominant age matches that of the prevalent host,1.03Ga Pikes Peak Granite. IRM acquisition experiments were performed to identify the principal magnetic phases as a mixture of Fe-Ti oxide phases, likely to be low-Ti magnetite and hematite. The sandstone consists of sub-rounded to rounded sand-sized quartz, angular feldspar (<5%), and detrital magnetite; selected samples have uniform grain size and uniform color arising from hematite cement. Although direct cover relationships are not preserved, a portion of the study sites are proximal to in situ near-horizontal sedimentary cover rocks that offer evidence against large tectonic rotation. Cores were collected using a gas-powered drill with a diamond bit and oriented using a sun compass. Where possible, cores were obtained on

  12. Measurement of vortex velocities over a wide range of vortex age, downstream distance and free stream velocity

    NASA Technical Reports Server (NTRS)

    Rorke, J. B.; Moffett, R. C.

    1977-01-01

    A wind tunnel test was conducted to obtain vortex velocity signatures over a wide parameter range encompassing the data conditions of several previous researchers while maintaining a common instrumentation and test facility. The generating wing panel was configured with both a revolved airfoil tip shape and a square tip shape and had a semispan aspect of 4.05/1.0 with a 121.9 cm span. Free stream velocity was varied from 6.1 m/sec to 76.2 m/sec and the vortex core velocities were measured at locations 3, 6, 12, 24 and 48 chordlengths downstream of the wing trailing edge, yielding vortex ages up to 2.0 seconds. Wing pitch angles of 6, 8, 9 and 12 deg were investigated. Detailed surface pressure distributions and wing force measurements were obtained for each wing tip configuration. Correlation with vortex velocity data taken in previous experiments is good. During the rollup process, vortex core parameters appear to be dependent primarily on vortex age. Trending in the plateau and decay regions is more complex and the machanisms appear to be more unstable.

  13. Conclusions from recent pionic--atom experiments

    SciTech Connect

    Gotta, D.; Hennebach, M.; Nekipelov, M.; Strauch, Th.; Amaro, F.; Covita, D. S.; Santos, J. M. F. dos; Veloso, J. F. C. A.; Anagnostopoulos, D. F.; Biri, S.; Gorke, H.; Gruber, A.; Hirtl, A.; Ishiwatari, T.; Marton, J.; Schmid, Ph.; Zmeskal, J.; Indelicato, P.; Jensen, Th.; Le Bigot, E.-O.

    2008-08-08

    The most recent pionic--hydrogen experiment marks the completion of a whole series of measurements, the main goal of which was to provide conclusive data on pion--nucleon interaction at threshold for comparison with calculations from Chiral perturbation theory. The precision achieved for hadronic shift and broadening of 0.2% and 2%, respectively, became possible by comprehensive studies of cascade effects in hydrogen and other light exotic atoms including results from the last years of LEAR operation. In order to obtain optimum conditions for the Bragg crystal spectrometer, the cyclotron trap II has been used to provide a suitable X--ray source. To characterize the bent crystal spectrometer, the cyclotron trap has been modified to operate as an electron--cyclotron resonance source, which produces with high intensity narrow X-ray transitions in the few keV range originating from highly charged ions.

  14. MULTI-ETHNIC REFERENCE VALUES FOR SPIROMETRY FOR THE 3–95 YEAR AGE RANGE: THE GLOBAL LUNG FUNCTION 2012 EQUATIONS

    PubMed Central

    Quanjer, Philip H.; Stanojevic, Sanja; Cole, Tim J.; Baur, Xaver; Hall, Graham L.; Culver, Bruce H.; Enright, Paul L.; Hankinson, John L.; Ip, Mary S.M.; Zheng, Jinping; Stocks, Janet

    2013-01-01

    Objective Derive continuous prediction equations and their lower limits of normal for spirometric indices, which are applicable globally. Material Over 160,000 data points from 72 centres in 33 countries were shared with the European Respiratory Society Global Lung Function Initiative. Eliminating data that could not be used (mostly missing ethnic group, some outliers) left 97,759 records of healthy nonsmokers (55.3% females) aged 2.5–95 years. Methods Lung function data were collated, and prediction equations derived using the LMS (λ, µ, σ) method, which allows simultaneous modelling of the mean (mu), the coefficient of variation (sigma) and skewness (lambda) of a distribution family. Results After discarding 23,572 records, mostly because they could not be combined with other ethnic or geographic groups, reference equations were derived for healthy individuals from 3–95 years for Caucasians (N=57,395), African Americans (N=3,545), and North (N=4,992) and South East Asians (N=8,255). FEV1 and FVC between ethnic groups differed proportionally from that in Caucasians, such that FEV1/FVC remained virtually independent of ethnic group. For individuals not represented by these four groups, or of mixed ethnic origins, a composite equation taken as the average of the above equations is provided to facilitate interpretation until a more appropriate solution is developed. Conclusion Spirometric prediction equations for the 3–95 age range are now available that include appropriate age-dependent lower limits of normal. They can be applied globally to different ethnic groups. Additional data from the Indian subcontinent, Arab, Polynesian, Latin American countries, and Africa will further improve these equations in the future. PMID:22743675

  15. Gender, Age and Season as Modifiers of the Effects of Diurnal Temperature Range on Emergency Room Admissions for Cause-Specific Cardiovascular Disease among the Elderly in Beijing

    PubMed Central

    Zheng, Shan; Wang, Minzhen; Li, Bei; Wang, Shigong; He, Shilin; Yin, Ling; Shang, Kezheng; Li, Tanshi

    2016-01-01

    Background: Diurnal temperature range (DTR) is an important index of climate change and variability. It is also a risk factor affecting human health. However, limited evidence is available to illustrate the effect of DTR modification on cause-specific cardiovascular disease among the elderly. Methods: A semi-parametric generalized additive model (GAM) was used to analyze the exposure-effect relationship between DTR and daily emergency room (ER) admissions for cause-specific cardiovascular diseases among the elderly from 2009 to 2011 in Beijing. We examined the effects of DTR for stratified groups by gender and age, and examined the effects of DTR in the warm season and cold season for cause-specific cardiovascular diseases. Results: Significant associations were found between DTR and ER admissions for all cardiovascular and cerebrovascular disease among elderly males, while DTR was significantly associated with ER admissions for all cardiovascular disease, ischemic heart disease and cerebrovascular disease among elderly females. People aged 75 years and older were more vulnerable to DTR. DTR caused greater adverse effects on both genders in the warm season, whereas the effect estimates on females were higher in cold season than in warm season. Conclusions: A short-term increase of DTR was significantly associated with ER admissions for cause-specific cardiovascular disease among the elderly in Beijing. Gender, age and season may modify the acute health effect of DTR. Some prevention programs that target the high risk subgroups in the elderly for impending large temperature changes may reduce the impact of DTR on people’s health. PMID:27128931

  16. Age- and sex-related reference ranges for eight plasma constituents derived from randomly selected adults in a Scottish new town.

    PubMed Central

    Gardner, M D; Scott, R

    1980-01-01

    The results of analysis of blood specimens from randomly selected adults aged 19-88 years in the new town of Cumbernauld were used to establish age- and sex-related reference ranges by the centile method (central 95%) for plasma calcium, phosphate, total protein, albumin, globulins, urea, creatinine, and urate. The possible existence of a subpopulation with a higher reference range for urea is mooted. PMID:7400337

  17. Childlessness and Psychological Well-Being in Midlife and Old Age: An Examination of Parental Status Effects across a Range of Outcomes

    ERIC Educational Resources Information Center

    Hansen, Thomas; Slagsvold, Britt; Moum, Torbjorn

    2009-01-01

    The study explores and distinguishes links between parental status (childless persons, parents with residential children, and empty nest parents) and a range of psychological well-being outcomes in midlife and old age. Data are from the first wave of the Norwegian Life Course, Ageing and Generation (NorLAG) study (n = 5,189). We separate outcomes…

  18. Lithofacies, Age, and Sequence Stratigraphy of the Carboniferous Lisburne Group in the Skimo Creek Area, Central Brooks Range

    USGS Publications Warehouse

    Dumoulin, Julie A.; Whalen, Michael T.; Harris, Anita G.

    2008-01-01

    The Lisburne Group, a mainly Carboniferous carbonate succession that is widely distributed across northern Alaska, contains notable amounts of oil and gas at Prudhoe Bay. Detailed studies of the Lisburne in the Skimo Creek area, central Brooks Range, delineate its lithofacies, age, conodont biofacies, depositional environments, and sequence stratigraphy and provide new data on its hydrocarbon source-rock and reservoir potential, as well as its thermal history, in this area. We have studied the Lisburne Group in two thrust sheets of the Endicott Mountains allochthon, herein called the Skimo and Tiglukpuk thrust sheets. The southern, Skimo Creek section, which is >900 m thick, is composed largely of even-bedded to nodular lime mudstone and wackestone intercalated with intervals of thin- to thick-bedded bioclastic packstone and grainstone. Some parts of the section are partially to completely dolomitized and (or) replaced by chert. A distinctive, 30-m-thick zone of black, organic-rich shale, lime mudstone, and phosphorite is exposed 170 m below the top of the Lisburne. The uppermost 40 m of section is also distinctive and made up of dark shale, lime mudstone, spiculite, and glauconitic grainstone. The northern, Tiglukpuk Creek section, which is similar to the Skimo Creek section but only ~760 m thick, includes more packstone and grainstone and less organic-rich shale. Analyses of conodonts and foraminifers indicate that both sections range in age from late Early Mississippian (Osagean) through Early Pennsylvanian (early Morrowan) and document a hiatus of at least 15 m.y. at the contact between the Lisburne and the overlying Siksikpuk Formation. No evidence of subaerial exposure was observed along this contact, which may represent a submarine erosional surface. Lithofacies and biofacies imply that the Lisburne Group in the study area was deposited mainly in midramp to outer-ramp settings. Deepest water strata are mud rich and formed below storm or fair-weather wave

  19. NWCC Transmission Case Study Conclusions Summary

    SciTech Connect

    Steve Wiese, Terry Allison

    2000-09-01

    OAK-B135 The NWCC Transmission Case Studies Conclusions Summary In the spring of 1999, the Utility Wind Interest Group (UWIG), with the cooperation of the National Wind Coordinating Committee (NWCC), conducted a forum on transmission issues associated with the production of energy from wind. As a result of this forum, a number of issues were identified which, if successfully resolved, could help reduce barriers to the future expansion of wind power. The NWCC, being a multi-stakeholder group, was in an ideal position to conduct follow-up activities among a cross-section of the interested parties. The follow-up activities took the form of three case studies in the areas of interest identified by forum participants: (1) Transmission policy and pricing; (2) ''Virtual wheeling'' arrangements; and, (3) Transmission system improvements. The case studies provide an interesting snapshot in time dealing with a range of issues associated with scheduled or planned regulatory and restructuring proceedings related to energy transmission. The NWCC Transmission Subcommittee and the UWIG reviewed early drafts of the case studies in November 1999. The case studies were conducted through a questionnaire and interview process with interested parties. In writing each case study, NWCC staff attempted to identify all stakeholder groups with an interest in each topic and solicit their input. While all parties do not agree on every issue presented, a serious effort has been made to present all views in an unbiased fashion. At the end of each case study, relevant conclusions are drawn and recommendations for next steps are provided where appropriate.

  20. The Stroop Color-Word Test: Influence of Age, Sex, and Education; and Normative Data for a Large Sample Across the Adult Age Range

    ERIC Educational Resources Information Center

    Van der Elst, Wim; Van Boxtel, Martin P. J.; Van Breukelen, Gerard J. P.; Jolles, Jelle

    2006-01-01

    The Stroop Color-Word Test was administered to 1,856 cognitively screened, healthy Dutch-speaking participants aged 24 to 81 years. The effects of age, gender, and education on Stroop test performance were investigated to adequately stratify the normative data. The results showed that especially the speed-dependent Stroop scores (time to complete…

  1. Environmental exposure of lead and iron deficit anemia in children age ranged 1-5 years: a cross sectional study.

    PubMed

    Shah, Faheem; Kazi, Tasneem Gul; Afridi, Hassan Imran; Baig, Jameel Ahmed; Khan, Sumaira; Kolachi, Nida Fatima; Wadhwa, Sham Kumar; Shah, Abdul Qadir

    2010-10-15

    Iron (Fe) deficiency is the most common nutritional problem among children and lead (Pb) toxicity is the most common environmental health threat to children all over the world. The objective of this study was to determine blood lead (BPb) levels and prevalence of Fe deficient anemia among 1 to 5year old children attending day care clinic in pediatric ward of civil hospital Karachi, Pakistan. A total of 340 children of both genders participating in this study, were screened for anemia. Among them 215 were anemic and 125 non-anemic. The anemic group was further divided in two groups on the basis of % hemoglobin (Hb), mild (Hb <10g/dL) and severe anemic group (Hb <8g/dL), while non-anemic as referent children (Hb >10g/dL). The blood samples were analysed for Pb and Fe, along with hematological parameters. The result indicated that anemic children had a higher mean values of Pb in blood than referent children with Hb >10g/dL. The Pb levels <100μg/L were detected in 40% referent children while 60% of them had >10μg/dL. The BPb concentration in severe anemic children (53%) was found in the range of 100-200μg/L, whereas 47% had >200μg/L. The significant negative correlations of BPb level with % Hb (r=-0.514 and r=-0.685) and Fe contents (r=-0.522, r=-0.762, p<0.001) were observed in mild and severe anemic children respectively. While positive correlation was observed between BPb and age of both group and genders (r=0.69, p<0.01). The BPb levels were significantly associated with biochemical indices in the blood which have the potential to be used as biomarkers of Pb intoxication and Fe deficient anemia. PMID:20801490

  2. A summary and conclusions from the meeting.

    PubMed

    Marshall, Fiona H

    2005-01-01

    The Wenner-Gren meeting in Stockholm saw the arrival of a new era in the field of heptaspanning receptor oligomerization. The concept of direct physical and functionally relevant interactions between multiple seven transmembrane (7TMs) was considered by many to be an artifact of the experimental systems or techniques used for analysis. However, during the course of the meeting at Stockholm, we were presented with an overwhelming set of evidence ranging from actual photographs of receptor dimers, through biochemical and cellular evidence, up to physiologically relevant data in animal models and human cells. We agreed that the "hypothesis" of receptor oligomerization has come of age and can now essentially be considered an established "fact." Those of us submitting papers in the area no longer expect to get the same level of skepticism from referees (well, one can always hope!). The symposium began with an energizing talk from Lefkowitz, describing the early work in his lab leading to the cloning of the first 7TM the beta2AR, followed up with the many important discoveries on the mechanisms of receptor signaling and desensitization. We were brought right up to date on the current state of thinking on receptor signaling, much of which occurs not only through G proteins but through beta-arrestin and GRKs. The meeting was organized by those who laid the foundations of our current understanding of receptor-receptor interactions. As long ago as the early 1980s, Agnati and Fuxe demonstrated that receptor-receptor interactions occurred between neuropeptides and monoamine receptors in the CNS and proposed the idea of receptor mosaics made up of clusters of receptors (Agnati et al., 1982; Fuxe et al., 1983). During the 1990s, biochemical evidence suggesting dimerization of receptors was accumulating, particularly in the lab of one of the other meeting organizers, Michel Bouvier. Bouvier was the first to provide direct biochemical evidence for 7TM homodimers using

  3. Long-range transport of black carbon to the Pacific Ocean and its dependence on aging timescale

    NASA Astrophysics Data System (ADS)

    Zhang, J.; Liu, J.; Tao, S.; Ban-Weiss, G. A.

    2015-10-01

    Improving the ability of global models to predict concentrations of black carbon (BC) over the Pacific Ocean is essential to evaluate the impact of BC on marine climate. In this study, we tag BC tracers from 13 source regions around the globe in a global chemical transport model, Model for Ozone and Related Chemical Tracers, version 4 (MOZART-4). Numerous sensitivity simulations are carried out varying the aging timescale of BC emitted from each source region. The aging timescale for each source region is optimized by minimizing errors in vertical profiles of BC mass mixing ratios between simulations and HIAPER Pole-to-Pole Observations (HIPPO). For most HIPPO deployments, in the Northern Hemisphere, optimized aging timescales are less than half a day for BC emitted from tropical and midlatitude source regions and about 1 week for BC emitted from high-latitude regions in all seasons except summer. We find that East Asian emissions contribute most to the BC loading over the North Pacific, while South American, African and Australian emissions dominate BC loadings over the South Pacific. Dominant source regions contributing to BC loadings in other parts of the globe are also assessed. The lifetime of BC originating from East Asia (i.e., the world's largest BC emitter) is found to be only 2.2 days, much shorter than the global average lifetime of 4.9 days, making the contribution from East Asia to the global BC burden only 36 % of that from the second largest emitter, Africa. Thus, evaluating only relative emission rates without accounting for differences in aging timescales and deposition rates is not predictive of the contribution of a given source region to climate impacts. Our simulations indicate that the lifetime of BC increases nearly linearly with aging timescale for all source regions. When the aging rate is fast, the lifetime of BC is largely determined by factors that control local deposition rates (e.g., precipitation). The sensitivity of lifetime to aging

  4. Long-range transport of black carbon to the Pacific Ocean and its dependence on aging timescale

    NASA Astrophysics Data System (ADS)

    Zhang, J.; Liu, J.; Tao, S.; Ban-Weiss, G. A.

    2015-06-01

    Improving the ability of global models to predict concentrations of black carbon (BC) over the Pacific Ocean is essential to evaluate the impact of BC on marine climate. In this study, we tag BC tracers from 13 source regions around the globe in a global chemical transport model MOZART-4. Numerous sensitivity simulations are carried out varying the aging timescale of BC emitted from each source region. The aging timescale for each source region is optimized by minimizing errors in vertical profiles of BC mass mixing ratios between simulations and HIAPER Pole-to-Pole Observations (HIPPO). For most HIPPO deployments, in the Northern Hemisphere, optimized aging timescales are less than half a day for BC emitted from tropical and mid-latitude source regions, and about 1 week for BC emitted from high latitude regions in all seasons except summer. We find that East Asian emissions contribute most to the BC loading over the North Pacific, while South American, African and Australian emissions dominate BC loadings over the South Pacific. Dominant source regions contributing to BC loadings in other parts of the globe are also assessed. The lifetime of BC originating from East Asia (i.e., the world's largest BC emitter) is found to be only 2.2 days, much shorter than the global average lifetime of 4.9 days, making East Asia's contribution to global burden only 36 % of BC from the second largest emitter, Africa. Thus, evaluating only relative emission rates without accounting for differences in aging timescales and deposition rates is not predictive of the contribution of a given source region to climate impacts. Our simulations indicate that lifetime of BC increases nearly linearly with aging timescale for all source regions. When aging rate is fast, the lifetime of BC is largely determined by factors that control local deposition rates (e.g. precipitation). The sensitivity of lifetime to aging timescale depends strongly on the initial hygroscopicity of freshly emitted BC

  5. Age group estimation in free-ranging African elephants based on acoustic cues of low-frequency rumbles

    PubMed Central

    Stoeger, Angela S.; Zeppelzauer, Matthias; Baotic, Anton

    2015-01-01

    Animal vocal signals are increasingly used to monitor wildlife populations and to obtain estimates of species occurrence and abundance. In the future, acoustic monitoring should function not only to detect animals, but also to extract detailed information about populations by discriminating sexes, age groups, social or kin groups, and potentially individuals. Here we show that it is possible to estimate age groups of African elephants (Loxodonta africana) based on acoustic parameters extracted from rumbles recorded under field conditions in a National Park in South Africa. Statistical models reached up to 70 % correct classification to four age groups (infants, calves, juveniles, adults) and 95 % correct classification when categorising into two groups (infants/calves lumped into one group versus adults). The models revealed that parameters representing absolute frequency values have the most discriminative power. Comparable classification results were obtained by fully automated classification of rumbles by high-dimensional features that represent the entire spectral envelope, such as MFCC (75 % correct classification) and GFCC (74 % correct classification). The reported results and methods provide the scientific foundation for a future system that could potentially automatically estimate the demography of an acoustically monitored elephant group or population. PMID:25821348

  6. Normal reference ranges for and variability in the levels of blood manganese and selenium by gender, age, and race/ethnicity for general U.S. population.

    PubMed

    Jain, Ram B; Choi, Y Sammy

    2015-04-01

    Data from National Health and Nutrition Examination Survey for the period 2011-2012 were used to determine normal reference ranges and percentile distributions for manganese (Mn) and selenium (Se) in blood by gender, age, race/ethnicity, socioeconomic status as determined by annual family income, and smoking status. The effect of gender, age, race/ethnicity, family income, and smoking status on the levels of Mn and Se was also determined by fitting regression models. Males had lower adjusted levels of Mn and higher adjusted levels of Se than females. Adjusted levels of Mn decreased with increase in age but adjusted levels of Se were lower in adolescents aged 12-19 years than adults aged 20-64 years. Non-Hispanic black (NHB) had the lowest levels of both Mn and Se and non-Hispanic Asians (NHAS) had the highest levels of both Mn and Se. Non-Hispanic white (NHW) and NHB had lower levels of Mn than Hispanics (HISP) and NHAS. NHB and HISP had lower levels of Se than NHW and NHAS. Low annual income (<$20,000) was associated with lower levels of Se than high annual income (≥$55,000). Smoking negatively affected the adjusted levels of Se among seniors aged ≥65 years but this was not observed in other age groups. Mn levels were not affected by smoking.

  7. 4.11 Summary and Conclusions

    NASA Astrophysics Data System (ADS)

    Noßke, D.; Mattsson, S.; Johansson, L.

    This document is part of Subvolume A 'Fundamentals and Data in Radiobiology, Radiation Biophysics, Dosimetry and Medical Radiological Protection' of Volume 7 'Medical Radiological Physics' of Landolt-Börnstein - Group VIII 'Advanced Materials and Technologies'. It contains the Section '4.11 Summary and Conclusions' of the Chapter '4 Dosimetry in Nuclear Medicine Diagnosis and Therapy'.

  8. The TOEFL and Domestic Students: Conclusively Inappropriate

    ERIC Educational Resources Information Center

    Johnson, Dixon C.

    1977-01-01

    This experiment tested college students whose first language is English with the TOEFL examination. The major conclusion was that TOEFL scores do not relate to academic aptitude or performance of domestic students and to evaluate English competency of native speakers with this test is inappropriate. (CHK)

  9. The Mount Evans batholith in the Colorado Front Range: revision of its age and reinterpretation of its structure

    USGS Publications Warehouse

    Aleinikoff, J.N.; Reed, J.C.; Dewitt, E.

    1993-01-01

    The Mount Evans batholith is composed of a main phase of massive to conspicuously foliated monzogranite and granodiorite and undeformed aplite and pegmatite. The Mount Evans batholith was previously considered to be part of the 1.7 Ga Routt Plutonic Suite. New U-Pb zircon ages on four samples (granodiorite, monzogranite, and granite), however, indicate that the batholith was emplaced at 1442 ?? 2 Ma and belongs to the Berthoud Plutonic Suite. Most of the batholith has igneous textures and structures, except in the vicinity of the Idaho Springs-Ralston shear zone where those features are tectonically recrystallized and foliated. The Mount Evans batholith is anomalous in composition and structure compared to most other 1.4 Ga plutons of the southwestern US. The differences probably reflect different sources of partial melting; the specific tectonic setting where rocks of such disparate origin are temporally and spatially juxtaposed is not understood. -from Authors

  10. Zircon U-Pb age of the Pescadero felsite: A late Cretaceous igneous event in the forearc, west-central California Coast Ranges

    USGS Publications Warehouse

    Ernst, W.G.; Martens, U.C.; McLaughlin, R.J.; Clark, J.C.; Moore, Diane E.

    2011-01-01

    Weathered felsite is associated with the late Campanian-Maastrichtian Pigeon Point Formation near Pescadero, California. Poorly exposed, its age and correlation are uncertain. Is it part of the Pigeon Point section west of the San Gregorio-Hosgri fault? Does it rest on Nacimiento block basement? Is it dextrally offset from the Oligocene Cambria Felsite, ~185 km to the southeast? Why is a calc-alkaline hypabyssal igneous rock intrusive into the outboard accretionary prism? To address these questions, we analyzed 43 oscillatory-zoned zircon crystals from three incipiently recrystallized pumpellyite ?? prehnite ?? laumontite-bearing Pescadero felsite samples by sensitive high-resolution ion microprobe-reverse geometry (SHRIMPRG) and laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) techniques. Thirty-three zircons gave late Mesozoic U-Pb ages, with single-grain values ranging from 81 to 167 Ma; ten have pre-Mesozoic, chiefl y Proterozoic ages. A group of the four youngest Pescadero zircons yielded an apparent maximum igneous age of ca. 86-90 Ma. Refl ecting broad age scatter and presence of partly digested sandstone inclusions, we interpret the rest of the zircons (perhaps all) as xenocrysts. Twenty-three zircons were separated and analyzed from two samples of the similar Cambria Felsite, yielding a unimodal 27 Ma U-Pb age. Clearly, the origin of the Upper Oligocene Cambria Felsite is different from that of the Upper Cretaceous Pescadero felsite; these rocks are not correlated, and do not constrain displacement along the San Gregorio-Hosgri fault. Peak ages differ slightly, but relative probability curves for Mesozoic and pre-Mesozoic Pescadero zircons compare well, for example, with abundant U-Pb age data for detrital zircons from Franciscan metaclastic strata ~100 km to the east in the Diablo Range- San Francisco Bay area, San Joaquin Great Valley Group turbidites, Upper Cretaceous Nacimiento block Franciscan strata, and Upper Cretaceous

  11. Basin and range-age reactivation of the ancestral Rocky Mountains in Texas Panhandle: evidence from Ogallala Formation

    SciTech Connect

    Budnik, R.T.

    1984-04-01

    The Ogallala Formation (Neogene) is a widespread syntectonic alluvial apron that was shed eastward from the Rio Grande rift and related uplifts in Colorado and New Mexico during Basin and Range extension. In the Texas Panhandle, the Ogallala completely buried Ancestral Rocky Mountain (Pennsylvanian) structures. Renewed movement on these older structures during the Neogene influenced the thickness and facies distribution of the Ogallala. The Ogallala thickens into the Palo Duro, Dalhart, and Anadarko basins. Major distributary channels on Ogallala alluvial fans coincide with the axes of these basins, whereas major interchannel areas overlie intervening uplifts. Second-order structures subtly influenced the unit as well. For example, the Carson basin, a Pennsylvanian rhomb graben along the Amarillo uplift, the Ogallala is over 250 m (820 ft) thick compared with 90 m (275 ft) in adjacent areas. Within the Palo Duro basin, local highs controlled the distribution of thin, interchannel flood-basin and lacustrine deposits. Thicker, braided-stream channel deposits follow local lows. Later movement on the Amarillo uplift broadly folded the Ogallala. The southern high plains surface subtly reflects basement structure, with topographic highs overlying basement highs, suggesting post-Ogallala deformation within the Palo Duro basin. The Amarillo uplift is approximately perpendicular to the Rio Grande rift and parallel to the direction of Basin and Range extension. Thus, the stress field that produced the rift may have caused strike-slip movement and reactivation of the Carson basin along the Amarillo uplift.

  12. Hydrological evidence for a North Atlantic oscillation during the Little Ice Age outside its range observed since 1850

    NASA Astrophysics Data System (ADS)

    Martín-Puertas, C.; Dorado-Liñán, I.; Brauer, A.; Zorita, E.; Valero-Garcés, B. L.; Gutierrez, E.

    2011-12-01

    An annual-resolved precipitation reconstruction for the last 800 yr in Southern Spain has been performed using stable carbon isotope (δ13C) of Pinus nigra tree rings. The reconstruction exhibits high- to low-frequency variability and distinguishes a Little Ice Age (LIA, AD 1350-1850) characterized by lower averaged rainfall than both in the transition from the Medieval Climate Anomaly to the LIA and in the 20th century. The driest conditions are recorded during the Maunder solar Minimum (mid 17th-early 18th centuries), in good agreement with the Spanish documentary archive. Similar linkage between solar activity (maximum/minimum) and precipitation (increase/decrease) is observed throughout the entire LIA. Additionally, the relationship between the hydrological pattern in the Iberian Peninsula and Morocco during the LIA suggests different spatial distribution of precipitation in the south-eastern sector of the North Atlantic region such as it is known currently. Whereas in the instrumental record the precipitation evolves similarly in both regions and opposite to the North Atlantic oscillation (NAO) index, the coldest periods of the LIA shows a contrasting pattern with drier conditions in the South of Spain and wetter in Northern Africa. We suggest an extreme negative NAO conditions, accompanied by a southward excursion of the winter rainfall band beyond that observed in the last century, can explain this contrast. The sustained NAO conditions could have been triggered by solar minima and higher volcanic activity during the LIA.

  13. Aerosol transport from Chiang Mai, Thailand to Mt. Lulin, Taiwan - Implication of aerosol aging during long-range transport

    NASA Astrophysics Data System (ADS)

    Chuang, Ming-Tung; Lee, Chung-Te; Chou, Charles C.-K.; Engling, Guenter; Chang, Shih-Yu; Chang, Shuenn-Chin; Sheu, Guey-Rong; Lin, Neng-Huei; Sopajaree, Khajornsak; Chang, You-Jia; Hong, Guo-Jun

    2016-07-01

    The transport of biomass burning (BB) aerosol from Indochina may cause a potential effect on climate change in Southeast Asia, East Asia, and the Western Pacific. Up to now, the understanding of BB aerosol composition modification during long-range transport (LRT) is still very limited due to the lack of observational data. In this study, atmospheric aerosols were collected at the Suthep/Doi Ang Khang (DAK) mountain sites in Chiang Mai, Thailand and the Lulin Atmospheric Background Station (Mt. Lulin) in central Taiwan from March to April 2010 and from February to April 2013, respectively. During the study period, an upwind and downwind relationship between the Suthep/DAK and Lulin sites (2400 km apart) was validated by backward trajectories. Comprehensive aerosol properties were resolved for PM2.5 water-soluble inorganic ions, carbonaceous content, water-soluble/insoluble organic carbon (WSOC/WIOC), dicarboxylic acids and their salts (DCAS), and anhydrosugars. A Modification Factor (MF) is proposed by employing non-sea-salt potassium ion (nss-K+) or fractionalized elemental carbon evolved at 580 °C after pyrolized OC correction (EC1-OP) as a BB aerosol tracer to evaluate the mass fraction changes of aerosol components from source to receptor regions during LRT. The MF values of nss-SO42-, NH4+, NO3-, OC1 (fractionalized organic carbon evolved from room temperature to 140 °C), OP (pyrolized OC fraction), DCAS, and WSOC were above unity, which indicated that these aerosol components were enhanced during LRT as compared with those in the near-source region. In contrast, the MF values of anhydrosugars ranged from 0.1 to 0.3, indicating anhydrosugars have degraded during LRT.

  14. The common premise for uncommon conclusions.

    PubMed

    Coady, C A J

    2013-05-01

    Recent controversy over philosophical advocacy of infanticide (or the comically-styled euphemism 'postnatal abortion') reveals a surprisingly common premise uniting many of the opponents and supporters of the practice. This is the belief that the moral status of the early fetus or embryo with respect to a right to life is identical to that of a newly born or even very young baby. From this premise, infanticidists and strong anti-abortionists draw opposite conclusions, the former that the healthy newly born have no inherent right to life and the latter that minute embryos and the very early fetus have the same right to life as young babies. (Indeed strong anti-abortionists tend to regard this right to life as identical to that possessed by adult humans.) This paper argues that these opposed conclusions are both deeply implausible and that the implausibility resides in the common premise. The argument requires some attention to the structure of the philosophical case underpinning the supposed vice of speciesism that has been given intellectual currency by many philosophers, most notably Peter Singer, and also to the reasoning behind the strong anti-abortionist adoption of the common premise. PMID:23637428

  15. The common premise for uncommon conclusions.

    PubMed

    Coady, C A J

    2013-05-01

    Recent controversy over philosophical advocacy of infanticide (or the comically-styled euphemism 'postnatal abortion') reveals a surprisingly common premise uniting many of the opponents and supporters of the practice. This is the belief that the moral status of the early fetus or embryo with respect to a right to life is identical to that of a newly born or even very young baby. From this premise, infanticidists and strong anti-abortionists draw opposite conclusions, the former that the healthy newly born have no inherent right to life and the latter that minute embryos and the very early fetus have the same right to life as young babies. (Indeed strong anti-abortionists tend to regard this right to life as identical to that possessed by adult humans.) This paper argues that these opposed conclusions are both deeply implausible and that the implausibility resides in the common premise. The argument requires some attention to the structure of the philosophical case underpinning the supposed vice of speciesism that has been given intellectual currency by many philosophers, most notably Peter Singer, and also to the reasoning behind the strong anti-abortionist adoption of the common premise.

  16. Epistemology applied to conclusions of expert reports.

    PubMed

    Lucena-Molina, Jose-Juan

    2016-07-01

    It is believed that to build a robust reasoning logic to make probabilistic inferences in forensic science from a merely mathematical or logistical viewpoint is not enough. Mathematical logic is the positive science of reasoning and as for that it is only interested in the positive calculus of its validity, regardless any prior ontological assumption. But without a determined ontology and epistemology which imply to define the concepts that they will use, it seems difficult that the proposed scientifically correct mathematical solution be successful as a European standard for making conclusions in forensic reports because it has to be based on judicial language. Forensic experts and Courts are not interested in the development of a positive science but in a practical science: in clarifying whether certain known facts are related to a possible crime. Therefore, not only the coherence of the demonstrative logic reasoning used (logic of propositions) is important, but also the precision of the concepts used by language and consistency among them in reasoning (logic of concepts). There is a linguistic level essential for a successful communication between the forensic practitioner and the Court which is mainly related, in our opinion, to semantics and figures of speech. The first one is involved because words used in forensic conclusions often have different meanings - it is said that they are polysemic - and the second one because there is often metonymy as well. Besides, semantic differences among languages regarding words with the same etymological root add another difficulty for a better mutual understanding. The two main European judicial systems inherit a wide and deep culture related to evidence in criminal proceedings and each of them has coined their own terminology but there are other two more abstract levels such as logical and epistemological, where we can find solid arguments by which terms used at legal level on conclusions of forensic reports could be

  17. Epistemology applied to conclusions of expert reports.

    PubMed

    Lucena-Molina, Jose-Juan

    2016-07-01

    It is believed that to build a robust reasoning logic to make probabilistic inferences in forensic science from a merely mathematical or logistical viewpoint is not enough. Mathematical logic is the positive science of reasoning and as for that it is only interested in the positive calculus of its validity, regardless any prior ontological assumption. But without a determined ontology and epistemology which imply to define the concepts that they will use, it seems difficult that the proposed scientifically correct mathematical solution be successful as a European standard for making conclusions in forensic reports because it has to be based on judicial language. Forensic experts and Courts are not interested in the development of a positive science but in a practical science: in clarifying whether certain known facts are related to a possible crime. Therefore, not only the coherence of the demonstrative logic reasoning used (logic of propositions) is important, but also the precision of the concepts used by language and consistency among them in reasoning (logic of concepts). There is a linguistic level essential for a successful communication between the forensic practitioner and the Court which is mainly related, in our opinion, to semantics and figures of speech. The first one is involved because words used in forensic conclusions often have different meanings - it is said that they are polysemic - and the second one because there is often metonymy as well. Besides, semantic differences among languages regarding words with the same etymological root add another difficulty for a better mutual understanding. The two main European judicial systems inherit a wide and deep culture related to evidence in criminal proceedings and each of them has coined their own terminology but there are other two more abstract levels such as logical and epistemological, where we can find solid arguments by which terms used at legal level on conclusions of forensic reports could be

  18. Ovarian cycle activity varies with respect to age and social status in free-ranging elephants in Addo Elephant National Park, South Africa

    PubMed Central

    Freeman, Elizabeth W.; Meyer, Jordana M.; Putman, Sarah B.; Schulte, Bruce A.; Brown, Janine L.

    2013-01-01

    Free-ranging African elephants live in a fission–fusion society, at the centre of which is the matriarch. Matriarchs are generally older females that guide their families to resources and co-ordinate group defense. While much is known about elephant society, knowledge is generally lacking about how age affects the physiology of wild elephants. Investigation of the ovarian activity of free-ranging elephants could provide insight into the reproductive ageing process, with implications for population management. Faecal samples were collected from 46 individuals ranging in age from 14 to 60 years for a 2-year period, and progestagen metabolite analyses were used to examine relationships between social status, age, season, and ovarian activity in female elephants in Addo Elephant National Park, South Africa. Social status was the strongest predictor of faecal progestagen metabolite concentrations in non-pregnant elephants, with grand matriarchs (n = 6) having the lowest values compared with matriarchs (n = 21) and non-matriarch females (n = 19). Likewise, social status and age were the strongest predictors of faecal progestagen metabolite concentrations in pregnant elephants (n = 27). The number of years since a non-pregnant female gave birth to her last calf (post-partum duration) was longer for older females with a higher social status, as well as during the dry season. Our results indicate that social standing and age of elephants are related to reproductive function, and that older females exhibit reductions in ovarian capacity. These results expand our understanding of reproduction and fertility throughout an elephant's lifespan, and the factors that impact gonadal function in free-ranging females. Given that possible over-abundance of elephants in areas such as Addo Elephant National Park is fuelling the debate over how best to manage these populations, knowledge about the reproductive potential of high-ranking females can provide managers with

  19. Conclusion: Major Findings and Future Activities.

    NASA Technical Reports Server (NTRS)

    Rosenzweig, Cynthia E.; Hillel, Daniel

    2015-01-01

    The Agricultural Model Intercomparison and Improvement Project (AgMIP) incorporates a number of major advances in the way that climate impacts, vulnerability, and adaptation are being simulated. At its core is a protocol approach that results in impact assessments being more scientifically credible and thus ultimately having greater value to the wide range of agricultural stakeholders. Moreover, the use of the protocol approach enables closer scrutiny and intercomparison of models and methods so that they can be improved over time. By creating a truly trans-disciplinary, systems-based approach, AgMIP impact assessments and evaluation of adaptations become useful to agricultural decision-makers at multiple scales. The chapters in this two-part set demonstrate the use of this approach and represent early steps towards the full realization of these new methods and their application.

  20. Using the accumulation of CBD-extractable iron and clay content to estimate soil age on stable surfaces and nearby slopes, Front Range, Colorado

    NASA Astrophysics Data System (ADS)

    Dethier, David P.; Birkeland, Peter W.; McCarthy, James A.

    2012-11-01

    In many transport-limited environments, morphology, pedogenic iron and clay content provide a basis for estimating the exposure age of soils and associated landforms. We measured citrate-buffered dithionite (CBD)-extractable Fe (Fed) and clay concentration in fresh rock, saprolite, morainal and colluvial materials, and soil horizons from stable surfaces and hillslopes in the Colorado Front Range. Fresh igneous and high-grade metamorphic rocks contain < 1% Fed and 1 to 5% clay. As bedrock and surficial deposits age, Fed and clay accumulate from weathering and dustfall. Late Holocene regolith at warm, dry sites contains small amounts of Fed and clay, but relatively moist soils developed on early Holocene cirque deposits contain as much as 1.5% Fed and 8% clay. Concentrations and total profile accumulation of Fed and clay increase with age in soils developed on stable surfaces of glacial deposits as old as ~ 130 kyr. On stable sites, Fed and clay accumulation from weathering and dust is ~ 0.02 g cm- 2 kyr- 1 and ~ 0.2 g cm- 2 kyr- 1, respectively. We used the Fed and clay inventory in soil profiles at dated, stable Front Range surfaces to calculate accumulation functions, which allowed us to estimate soil age at hillslope sites. Heterogeneous parent material, particularly on hillslopes, and climate-related effects add to variability in measured relations. Mobile regolith in Gordon Gulch, one of the Boulder Creek Critical Zone Observatory (CZO) catchments, yields profile ages from about 0.5 to 5 × 104 yr, comparable to values measured using other techniques. Calculated profile ages are older on a north- vs. south-facing slope and increase from the drainage divide to the footslope. Ages calculated for stabilized colluvium and well-developed buried profiles at nearby hillslope sites (Lefthand, Ward and Rollinsville) suggest that these soils have stabilized over periods > 105 yr. In the absence of radiometric ages, the accumulation of Fed and clay in soils on stable

  1. Molecular distributions and stable carbon isotopic compositions of dicarboxylic acids and related compounds in aerosols from Sapporo, Japan: Implications for photochemical aging during long-range atmospheric transport

    NASA Astrophysics Data System (ADS)

    Aggarwal, Shankar G.; Kawamura, Kimitaka

    2008-07-01

    Molecular and stable carbon isotopic (δ13C value) compositions of dicarboxylic acids, ketoacids, and dicarbonyls in aerosol samples (i.e., total suspended particles) collected in Sapporo, northern Japan during spring and summer were determined to better understand the photochemical aging of organic aerosols during long-range transport from East Asia and Siberia. Their molecular distributions were characterized by the predominance of oxalic acid (C2) followed by malonic (C3) or occasionally succinic (C4) acids. Concentrations of total diacids ranged from 106-787 ng m-3 with ketoacids (13-81 ng m-3) and dicarbonyls (2.6-28 ng m-3) being less abundant. Water-soluble organic carbon (WSOC) comprised 23-69% of aerosol organic carbon (OC). OC to elemental carbon (EC) ratios were high (3.6-19, mean: 8.7). The ratios of C3/C4 and WSOC/OC did not show significant diurnal changes, suggesting that the Sapporo aerosols were not seriously affected by local photochemical processes and instead they were already aged. δ13C values of the dominant diacids (C2 - C4) ranged from -14.0 to -25.3‰. Largest δ13C values (-14.0 to -22.4‰, mean: -18.8‰) were obtained for C2, whereas smallest values (-25.1 to -31.4‰, mean: -28.1‰) were for azelaic acid (C9). In general, δ13C values of C2 - C4 diacids became less negative with aerosol aging (i.e., WSOC/OC), presumably due to isotopic fractionation during photochemical degradation of diacids. By comparing the δ13C values of diacids in the Sapporo aerosols with different air mass source regions, we suggest that although initial δ13C values of diacids depend on their precursor sources, the enrichment in 13C can be ascribed to aerosol photochemical aging.

  2. Conclusions on measurement uncertainty in microbiology.

    PubMed

    Forster, Lynne I

    2009-01-01

    Since its first issue in 1999, testing laboratories wishing to comply with all the requirements of ISO/IEC 17025 have been collecting data for estimating uncertainty of measurement for quantitative determinations. In the microbiological field of testing, some debate has arisen as to whether uncertainty needs to be estimated for each method performed in the laboratory for each type of sample matrix tested. Queries also arise concerning the estimation of uncertainty when plate/membrane filter colony counts are below recommended method counting range limits. A selection of water samples (with low to high contamination) was tested in replicate with the associated uncertainty of measurement being estimated from the analytical results obtained. The analyses performed on the water samples included total coliforms, fecal coliforms, fecal streptococci by membrane filtration, and heterotrophic plate counts by the pour plate technique. For those samples where plate/membrane filter colony counts were > or =20, uncertainty estimates at a 95% confidence level were very similar for the methods, being estimated as 0.13, 0.14, 0.14, and 0.12, respectively. For those samples where plate/membrane filter colony counts were <20, estimated uncertainty values for each sample showed close agreement with published confidence limits established using a Poisson distribution approach.

  3. Stratigraphic and structural implications of conodont and detrital zircon U-Pb ages from metamorphic rocks of the Coldfoot terrane, Brooks Range, Alaska

    USGS Publications Warehouse

    Moore, T.E.; Aleinikoff, J.N.; Harris, A.G.

    1997-01-01

    New paleontologic and isotopic data from the Emma Creek and Marion Creek schists of the Coldfoot terrane, Arctic Alaska superterrane, central Brooks Range, suggest Devonian and possibly younger ages of deposition for their sedimentary protoliths. Conodonts from marble of the Emma Creek schist, intruded by a roughly 392 Ma orthogneiss, are late Lochkovian (early Early Devonian, between about 408 and 396 Ma) and Silurian to Devonian at two other locations. Spherical to oblong detrital zircons from quartz-mica schist of the overlying Marion Creek schist yield mostly discordant U-Pb data suggestive of provenance ages of 3.0, 2.0-1.8, and 1.5-1.4 Ga; however, several euhedral grains of zircon from Marion Creek quartz-mica schist have concordant U-Pb ages from 370 to 360 Ma. The Marion Creek schist in our study area therefore is at least 26 m.y. younger than the Emma Creek schist. The age data imply that the protolith of the Emma Creek schist is age correlative with Devonian carbonate rocks in the Hammond and North Slope terranes, whereas the Marion Creek schist is age correlative with Upper Devonian and Lower Mississippian clastic sedimentary rocks of the Endicott Group in the Endicott Mountains terrane and shale and carbonate units in the De Long Mountains and Sheenjek River terranes. Consequently, tectonic models restoring the entire Coldfoot terrane beneath partly or wholly coeval rocks of the Hammond, Endicott Mountains, De Long Mountains, and Sheenjek River terranes of the Arctic Alaska superterrane require revision. Alternative reconstructions, including restoration of the Coldfoot terrane inboard of the Endicott Mountains terrane or outboard of the De Long Mountains and Sheenjek River terranes are plausible but require either larger amounts of shortening than previously suggested or indicate problematic facies relations. copyright. Published in 1997 by the American Geophysical Union.

  4. Screening Analysis : Volume 1, Description and Conclusions.

    SciTech Connect

    Bonneville Power Administration; Corps of Engineers; Bureau of Reclamation

    1992-08-01

    The SOR consists of three analytical phases leading to a Draft EIS. The first phase Pilot Analysis, was performed for the purpose of testing the decision analysis methodology being used in the SOR. The Pilot Analysis is described later in this chapter. The second phase, Screening Analysis, examines all possible operating alternatives using a simplified analytical approach. It is described in detail in this and the next chapter. This document also presents the results of screening. The final phase, Full-Scale Analysis, will be documented in the Draft EIS and is intended to evaluate comprehensively the few, best alternatives arising from the screening analysis. The purpose of screening is to analyze a wide variety of differing ways of operating the Columbia River system to test the reaction of the system to change. The many alternatives considered reflect the range of needs and requirements of the various river users and interests in the Columbia River Basin. While some of the alternatives might be viewed as extreme, the information gained from the analysis is useful in highlighting issues and conflicts in meeting operating objectives. Screening is also intended to develop a broad technical basis for evaluation including regional experts and to begin developing an evaluation capability for each river use that will support full-scale analysis. Finally, screening provides a logical method for examining all possible options and reaching a decision on a few alternatives worthy of full-scale analysis. An organizational structure was developed and staffed to manage and execute the SOR, specifically during the screening phase and the upcoming full-scale analysis phase. The organization involves ten technical work groups, each representing a particular river use. Several other groups exist to oversee or support the efforts of the work groups.

  5. The Ar-Ar age and petrology of Miller Range 05029: Evidence for a large impact in the very early solar system

    NASA Astrophysics Data System (ADS)

    Weirich, J. R.; Wittmann, A.; Isachsen, C. E.; Rumble, D.; Swindle, T. D.; Kring, D. A.

    2010-12-01

    Miller Range (MIL) 05029 is a slowly cooled melt rock with metal/sulfide depletion and an Ar-Ar age of 4517 ± 11 Ma. Oxygen isotopes and mineral composition indicate that it is an L chondrite impact melt, and a well-equilibrated igneous rock texture with a lack of clasts favors a melt pool over a melt dike as its probable depositional setting. A metallographic cooling rate of approximately 14 °C Ma-1 indicates that the impact occurred at least approximately 20 Ma before the Ar-Ar closure age of 4517 Ma, possibly even shortly after accretion of its parent body. A metal grain with a Widmanstätten-like pattern further substantiates slow cooling. The formation age of MIL 05029 is at least as old as the Ar-Ar age of unshocked L and H chondrites, indicating that endogenous metamorphism on the parent asteroid was still ongoing at the time of impact. Its metallographic cooling rate of approximately 14 °C Ma-1 is similar to that typical for L6 chondrites, suggesting a collisional event on the L chondrite asteroid that produced impact melt at a minimum depth of 5-12 km. The inferred minimum crater diameter of 25-60 km may have shattered the 100-200 km diameter L chondrite asteroid. Therefore, MIL 05029 could record the timing and petrogenetic setting for the observed lack of correlation of cooling rates with metamorphic grades in many L chondrites.

  6. Ar/Ar and U/Pb Ages and Geochemistry of the Benton Range Dike Swarm, SE California: New Evidence for an Independence Poly-phased Dike Swarm

    NASA Astrophysics Data System (ADS)

    Jourdan, F.; Renne, P. R.; Mundil, R.

    2005-12-01

    The Independence dike swarm (IDS) is a locally profuse, mostly NNW striking and ~700 km-long dike swarm occurring throughout southeastern California and possibly extending into northern Mexico. Dike compositions range from mafic to silicic (though strongly bimodal) and span the composition range of the coeval Sierran calc-alkaline arc plutons. Recent geochronological and structural investigations had cast some doubt on the accurate definition of the Independence dike swarm as the swarm more likely represents a poly-phase dike assemblage including at least two generation of dikes (i.e. 90 and 150 Ma; Chen and Moore, 1979; Coleman et al., 2000). To date, most of the geochronological and geochemical investigations available are strongly localized and part of the swarm lacks basic data. Here, we present new 40Ar39Ar (n=4) and U/Pb (n=1) ages and detailed major, trace and REE geochemical data on mafic (E-W to N-S) and more abundant silicic (NW-SE to N-S) dikes from the Benton Range dike swarm (BRDS), north-easternmost IDS. Two of the silicic dikes yielded concordant biotite 40Ar39Ar mini-plateau and weighted mean ages of 153 ± 2 and 152 ± 3 Ma (2 sigma), in agreement with previous K-Ar biotite ages of 150-155 Ma (Renne et al., 1987) and similar to the "accepted" age for the Independence swarm (~150 Ma). These biotite ages, however, may record a cooling age that significantly post-dates dike intrusion. One silicic dike yields a significantly older, preliminary 206Pb238U zircon age of 164.6 ± 0.8 Ma from single-crystal analyses. Two E-W striking mafic dikes which cross-cut NNW-striking silicic dikes yield hornblende plateau and mini-plateau ages of 171 ± 2 and 166 ± 2 Ma. BRDS chemical compositions are typical of mafic (SiO2 = 47-57 wt%; La/Ybn = 3-14) and granitic (SiO2 =67-77 wt%; La/Ybn = 5-31) arc magmas (e.g. Nb anomaly) and typify the known end-member compositions of the IDS. These results, together with compilated published and unpublished geochronological and

  7. A simple dose regimen of artesunate and amodiaquine based on arm span- or age range for childhood falciparum malaria: a preliminary evaluation.

    PubMed

    Sowunmi, Akintunde; Akinrinola, Ibukun A; Gbotosho, Grace O; Okuboyejo, Titilope M; Happi, Christian T

    2012-08-01

    A dose regimen of artesunate and amodiaquine based on arm span- or age range (DRAAAS), derived from a study of 1674 children, was compared with standard dose regimen of the same drugs calculated according to body weight (SDRAA) in 68 malarious children. Children on DRAAAS received 0.8-1.0 of artesunate/kg and 0.9-1.2 times amodiaquine/kg compared with those receiving SDRAA. Parasite and fever clearance and fall in hematocrit in the first 3 days were similar; both regimens were well tolerated. DRAAAS is simple and is efficacious.

  8. Population Parameters of Intermediate-age Star Clusters in the Large Magellanic Cloud. III. Dynamical Evidence for a Range of Ages Being Responsible for Extended Main-sequence Turnoffs

    NASA Astrophysics Data System (ADS)

    Goudfrooij, Paul; Puzia, Thomas H.; Chandar, Rupali; Kozhurina-Platais, Vera

    2011-08-01

    We present a new analysis of 11 intermediate-age (1-2 Gyr) star clusters in the Large Magellanic Cloud based on Hubble Space Telescope imaging data. Seven of the clusters feature main-sequence turnoff (MSTO) regions that are wider than can be accounted for by a simple stellar population, whereas their red giant branches (RGBs) indicate a single value of [Fe/H]. The star clusters cover a range in present-day mass from about 1 × 104 M sun to 2 × 105 M sun. We compare radial distributions of stars in the upper and lower parts of the MSTO region, and calculate cluster masses and escape velocities from the present time back to a cluster age of 10 Myr. Our main result is that for all clusters in our sample with estimated escape velocities v esc >~ 15 km s-1 at an age of 10 Myr, the stars in the brightest half of the MSTO region are significantly more centrally concentrated than the stars in the faintest half and more massive RGB and asymptotic giant branch stars. This is not the case for clusters with v esc <~ 10 km s-1 at an age of 10 Myr. We argue that the wide MSTO region of such clusters is caused mainly by a ~200-500 Myr range in the ages of cluster stars due to extended star formation within the cluster from material shed by first-generation stars featuring slow stellar winds. Dilution of this enriched material by accretion of ambient interstellar matter is deemed plausible if the spread of [Fe/H] in this ambient gas was very small when the second-generation stars were formed in the cluster. Based on observations with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555.

  9. Establishing Age-Adjusted Reference Ranges for Iris-Related Parameters in Open Angle Eyes with Anterior Segment Optical Coherence Tomography

    PubMed Central

    Peterson, Jeffrey R.; Blieden, Lauren S.; Chuang, Alice Z.; Baker, Laura A.; Rigi, Mohammed; Feldman, Robert M.; Bell, Nicholas P.

    2016-01-01

    Purpose Define criteria for iris-related parameters in an adult open angle population as measured with swept source Fourier domain anterior segment optical coherence tomography (ASOCT). Methods Ninety-eight eyes of 98 participants with open angles were included and stratified into 5 age groups (18–35, 36–45, 46–55, 56–65, and 66–79 years). ASOCT scans with 3D mode angle analysis were taken with the CASIA SS-1000 (Tomey Corporation, Nagoya, Japan) and analyzed using the Anterior Chamber Analysis and Interpretation software. Anterior iris surface length (AISL), length of scleral spur landmark (SSL) to pupillary margin (SSL-to-PM), iris contour ratio (ICR = AISL/SSL-to-PM), pupil radius, radius of iris centroid (RICe), and iris volume were measured. Outcome variables were summarized for all eyes and age groups, and mean values among age groups were compared using one-way analysis of variance. Stepwise regression analysis was used to investigate demographic and ocular characteristic factors that affected each iris-related parameter. Results Mean (±SD) values were 2.24 mm (±0.46), 4.06 mm (±0.27), 3.65 mm (±0.48), 4.16 mm (±0.47), 1.14 (±0.04), 1.51 mm2 (±0.23), and 38.42 μL (±4.91) for pupillary radius, RICe, SSL-to-PM, AISL, ICR, iris cross-sectional area, and iris volume, respectively. Both pupillary radius (P = 0.002) and RICe (P = 0.027) decreased with age, while SSL-to-PM (P = 0.002) and AISL increased with age (P = 0.001). ICR (P = 0.54) and iris volume (P = 0.49) were not affected by age. Conclusion This study establishes reference values for iris-related parameters in an adult open angle population, which will be useful for future studies examining the role of iris changes in pathologic states. PMID:26815917

  10. An acoustical assessment of pitch-matching accuracy in relation to speech frequency, speech frequency range, age and gender in preschool children

    NASA Astrophysics Data System (ADS)

    Trollinger, Valerie L.

    This study investigated the relationship between acoustical measurement of singing accuracy in relationship to speech fundamental frequency, speech fundamental frequency range, age and gender in preschool-aged children. Seventy subjects from Southeastern Pennsylvania; the San Francisco Bay Area, California; and Terre Haute, Indiana, participated in the study. Speech frequency was measured by having the subjects participate in spontaneous and guided speech activities with the researcher, with 18 diverse samples extracted from each subject's recording for acoustical analysis for fundamental frequency in Hz with the CSpeech computer program. The fundamental frequencies were averaged together to derive a mean speech frequency score for each subject. Speech range was calculated by subtracting the lowest fundamental frequency produced from the highest fundamental frequency produced, resulting in a speech range measured in increments of Hz. Singing accuracy was measured by having the subjects each echo-sing six randomized patterns using the pitches Middle C, D, E, F♯, G and A (440), using the solfege syllables of Do and Re, which were recorded by a 5-year-old female model. For each subject, 18 samples of singing were recorded. All samples were analyzed by the CSpeech for fundamental frequency. For each subject, deviation scores in Hz were derived by calculating the difference between what the model sang in Hz and what the subject sang in response in Hz. Individual scores for each child consisted of an overall mean total deviation frequency, mean frequency deviations for each pattern, and mean frequency deviation for each pitch. Pearson correlations, MANOVA and ANOVA analyses, Multiple Regressions and Discriminant Analysis revealed the following findings: (1) moderate but significant (p < .001) relationships emerged between mean speech frequency and the ability to sing the pitches E, F♯, G and A in the study; (2) mean speech frequency also emerged as the strongest

  11. Carbonaceous and inorganic composition in long-range transported aerosols over northern Japan: Implication for aging of water-soluble organic fraction

    NASA Astrophysics Data System (ADS)

    Aggarwal, Shankar Gopala; Kawamura, Kimitaka

    To better understand the influence of sources and atmospheric processing on aerosol chemical composition, we collected atmospheric particles in Sapporo, northern Japan during spring and early summer 2005 under the air mass transport conditions from Siberia, China and surrounding seas. The aerosols were analyzed for inorganic ions, organic carbon (OC), elemental carbon (EC), water-soluble organic carbon (WSOC), and the major water-soluble organic compound classes (i.e., dicarboxylic acids and sugars). SO 42- is the most abundant inorganic constituent (average 44% of the identified inorganic ion mass) followed by NH 4+ (21%) and NO 3- (13%). Concentrations of OC, EC, and WSOC ranged from 2.0-16, 0.24-2.9, and 0.80-7.9 μg m -3 with a mean of 7.4, 1.0, and 3.1 μg m -3, respectively. High OC/EC ratios (range: 3.6-19, mean: 8.7) were obtained, however WSOC/OC ratios (0.23-0.69, 0.44) do not show any significant diurnal changes. These results suggest that the Sapporo aerosols were already aged, but were not seriously affected by local photochemical processes. Identified water-soluble organic compounds (diacids + sugars) account for <10% of WSOC. Based on some marker species and air mass back trajectory analyses, and using stable carbon isotopic compositions of shorter-chain diacids (i.e., C 2-C 4) as photochemical aging factor of organic aerosols, the present study suggests that a fraction of WSOC in OC is most likely influenced by aerosol aging, although the OC loading in aerosols may be more influenced by their sources and source regions.

  12. [Primary age-related tauopathy (PART): a novel term to describe age-related tangle pathology encompassing a wide range from cognitively normal condition to senile dementia of the neurofibrillary tangle type].

    PubMed

    Yamada, Masahito

    2016-03-01

    It has been reported that neurofibrillary tangles (NFTs) are commonly observed in older people, and that some of older individuals with dementia have a large amount of NFTs in the medial temporal lobe without amyloid(Aβ) plaques, which have been referred to as senile dementia of the NFT type (SD-NFT), tangle-predominant senile dementia (TPSD), or tangle-only dementia. In 2014, our international collaborative group proposed a new term, "primary age-related tauopathy(PART)", to describe such age-related tangle pathology, clinically encompassing a wide range from normal to cognitive impairment/ dementia (SD-NFT). This nomenclature would provide a conceptual foundation for future studies leading to development of clinical diagnosis for this condition. PMID:27025089

  13. Science cases, wavelength ranges, and strategies for ELTs: some remarks and conclusions

    NASA Astrophysics Data System (ADS)

    Gustafsson, Bengt

    2008-04-01

    Discussions at the Symposium ELTs: Which wavelengths? in Lund in December 2007 are summarized and in particular comments are made on the relation between the optimization of the presently planned ELTs, and their corresponding background science cases. The division of labour between the ELTs and the JWST is commented on. The need for an ELT (and/or a future Space Telescope) for the optical wavelength region is stressed. Possible strategies for pursuing the ELT projects are commented on.

  14. Style and age of late Oligocene-early Miocene deformation in the southern Stillwater Range, west central Nevada: Paleomagnetism, geochronology, and field relations

    USGS Publications Warehouse

    Hudson, Mark R.; John, David A.; Conrad, James E.; McKee, Edwin H.

    2000-01-01

    Paleomagnetic and geochronologic data combined with geologic mapping tightly restrict the timing and character of a late Oligocene to early Miocene episode of large magnitude extension in the southern Stillwater Range and adjacent regions of west central Nevada. The southern Stillwater Range was the site of an Oligocene to early Miocene volcanic center comprising (1) 28.3 to 24.3 Ma intracaldera ash flow tuffs, lava flows, and subjacent plutons associated with three calderas, (2) 24.8 to 20.7 Ma postcaldera silicic dikes and domes, and (3) unconformably overlying 15.3 to 13.0 Ma dacite to basalt lava flows, plugs, and dikes. The caldera-related tuffs, lava flows, and plutons were tilted 60°-70° either west or east during the initial period of Cenozoic deformation that accommodated over 100% extension. Directions of remanent magnetization obtained from these extrusive and intrusive, caldera-related rocks are strongly deflected from an expected Miocene direction in senses appropriate for their tilt. A mean direction for these rocks after tilt correction, however, suggests that they were also affected by a moderate (33.4° ± 11.8°) component of counterclockwise vertical axis rotation. Paleomagnetic data indicate that the episode of large tilting occurred during emplacement of 24.8 to 20.7 Ma postcaldera dikes and domes. In detail, an apparent decrease in rotation with decreasing age of individual, isotopically dated bodies of the postcaldera group indicates that most tilting occurred between 24.4 and 24.2 Ma. The onset of tilting immediately following after the final caldera eruptions suggests that the magmatism and deformation were linked. Deformation was not driven by magma buoyancy, however, because tilting equally affected the caldera systems of different ages, including their plutonic roots. It is more likely that regional extension was focused in the southern Stillwater Range due to magmatic warming and reduction of tensile strength of the brittle crust

  15. Social relationships of nulliparous young adult females beyond the ordinary age of the first birth in a free-ranging troop of Japanese macaques (Macaca fuscata).

    PubMed

    Katsu, Noriko; Yamada, Kazunori; Nakamichi, Masayuki

    2013-01-01

    We describe the social relationships of young adult female Japanese macaques (Macaca fuscata) in a free-ranging troop in Arashiyama, Kyoto, Japan, who remained nulliparous beyond the ordinary age of first birth because of contraceptive administration. We observed 12 young nulliparous adult females (6-9 years old) for 270 h and 10 min from 2 February to 5 October 2010. The majority maintained close relationships with their mothers through proximity and grooming, whereas a few had very infrequent social interactions with their mothers. Most had asymmetrical grooming relationships; the grooming they received from unrelated adult females was less than the grooming they gave. Young adult females who had less frequent interactions with their mothers by either proximity or grooming received more grooming from a larger number of unrelated adult females than did those who had more frequent social interactions with their mothers. These results indicate that most young adult females who remained nulliparous beyond the ordinary age of first birth tended to maintain close relationships with their mothers, and their grooming relationships with unrelated adult females were inversely related to the degree of closeness with their mothers.

  16. Investigation of dielectric behavior of water and thermally aged of XLPE/BaTiO3 composites in the low-frequency range

    NASA Astrophysics Data System (ADS)

    Madani, Lakhdar; Belkhiat, Saad; Berrag, Amine; Nemdili, Saad

    2015-10-01

    Cross-Linked Polyethylene (XLPE) is widely used as insulation in electrical engineering, especially as cable insulation sheaths. In order to improve the dielectric properties susceptible to be modified under the effects of thermal aging and water in an absorption environment, polymers are mixed with ceramics. In this paper, the influence of barium titanate (BaTiO3), on the dielectric properties of XLPE has been studied. Dielectric parameters have been measured using an impedance analyzer RLC (WAYNE KERR 6420 type). Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy and X-ray diffraction were used as characterization techniques. The study has been carried out on two samples of XLPE. A pure sample of each were studied as a unloaded samples to be compared with samples of 5%wt, 10%wt, 15%wt and 20%wt. BaTiO3 loaded XLPE. Afterwards, the composites were subject to humidity and to thermal aging. The incorporation of BaTiO3 1∘C does not modify the crystallinity and morphology of the XLPE and 2∘C reduces the space charges therefore the dielectric losses. tgδ, ɛr and loss index are measured. Frequency response analysis has been followed in the frequency range (20-300 Hz). Experimental results show well that BaTiO3 as nano-filler improves the dielectric properties of XLPE but in excessive content can drive to the cracking and therefore to absorption of water.

  17. Age of the most recent event and range of slip rate on the central Maacama fault, near Ukiah, Mendocino County, California

    NASA Astrophysics Data System (ADS)

    Sickler, R. R.; Prentice, C. S.; Dengler, L. A.

    2005-12-01

    The 180-km-long Maacama fault zone (MFZ) is the northern extension of the Hayward and Rodgers Creek fault zones, which together comprise a major element of the San Andreas fault system in California. Previous studies indicate that the MFZ has been active in the Holocene and that it continues to produce numerous small-magnitude earthquakes. Fault creep has been reported and measured at several locations, also. However, little slip-rate or earthquake-chronology data are available for the MFZ. Our investigation combined fault trenching, cone penetrometer, and shallow seismic refraction studies on the active trace of the MFZ at a site approximately 3 km northeast of the town of Ukiah. Radiocarbon analyses of detrital charcoal collected from sediments associated with a strath-terrace riser yield a calibrated radiocarbon age range of 4840 to 4550 years BP. Our studies show that this terrace riser is right-laterally offset between 42 and 61 m, giving a slip rate of 8.7 to 13.4 mm/yr. We also determined that the most recent earthquake to cause surface rupture on this section of the Maacama fault, occurred sometime after 1410 AD, but before 1660 AD. If this earthquake is the same earthquake interpreted from evidence exposed in trenches excavated approximately 7 km southeast of this site, then it occurred between 1520 AD and 1660 AD. Thus, the minimum and maximum slip rate values of 8.7 and 13.4 mm/yr, when combined with the minimum and maximum years of elapsed time since the most recent earthquake, yield a strain accumulation of 3.0 to 6.5 m. However, the creep rate of the MFZ approximately 7 km southeast of our site is about 4.5 mm/yr. If this creep rate is representative of the long-term creep rate on this section of the MFZ, then the strain accumulation at our site may be between 1.4 to 4.3 m. If this slip is released in a single earthquake it would correspond to a magnitude ranging between Mw 7.0 to 7.6. These data suggest that the MFZ is a significant seismic hazard

  18. Age and composition of Archean crystalline rocks from the southern Madison Range, Montana. Implications for crustal evolution in the Wyoming craton

    SciTech Connect

    Mueller, P.A.; Shuster, R.D. ); Wooden, J.L. ); Erslev, E.A. ); Bowes, D.R. )

    1993-04-01

    The southern Madison Range of southwestern Montana contains two distinct Precambrian lithologic assemblages: (1) a complex of tonalitic to granitic gneisses that has been thrust over (2) a medium-grade metasupracrustal sequence dominated by pelitic schist. Crystallization ages for the protolith of a granodioritic gneiss that intruded the metasupracrustal sequence ([approximately]2.6 Ga)-along with an intercalated meta-andesite ([approximately]2.7 Ga) confirm the sequence as Archean. Chemical (major and trace element), isotopic (Rb-Sr, Sm-Nd, Pb-Pb), and geochronologic (U-Pb zircon) data for selected components of the gneiss complex indicate two groups of gneisses: an older, tonalitic to trondhjemitic group ([approximately]3.3 Ga) and a younger, mostly granitic group ([approximately]2.7 Ga). Both groups of gneisses exhibit the radiogenic Pb and nonradiogenic Nd isotopic signature characteristic of Middle and Late Archean rocks from throughout the Wyoming province. The older gneisses, in particular, appear to be compositionally, isotopically, and chronologically comparable to other Middle Archean gneisses from the northern part of the province (for example, Beartooth Mountains). The Late Archean gneisses, however, exhibit some distinct differences relative to their temporal counterparts, including (1) trace-element patterns that are more suggestive of crustal melts than subduction activity and (2) higher initial Sr isotopic ratios that suggest more involvement of older crust in their petrogenesis. These comparisons suggest that the juxtaposition of Late Archean terranes in the northern Wyoming province was the result, at least in part, of intracratonic processes. 41 refs., 6 figs., 2 tabs.

  19. Predicting borderline personality disorder features from personality traits, identity orientation, and attachment styles in Italian nonclinical adults: issues of consistency across age ranges.

    PubMed

    Fossati, Andrea; Borroni, Serena; Feeney, Judith; Maffei, Cesare

    2012-04-01

    The aims of this study were to assess whether Borderline Personality Disorder (BPD) features could be predicted by Big Five traits, impulsivity, identity orientation, and adult attachment patterns in a sample of 1,192 adult nonclinical participants, and to evaluate the consistency of these regression models across four age groups (<30 years, 30-39 years, 40-49 years, and >50 years, respectively). In the full sample, measures of neuroticism (N), impulsivity, and anxious insecure attachment were substantial predictors of BPD features (adjusted R(2) = .38, p < .001). Attachment scales were significant predictors of BPD features across all age groups, but different scales were relevant in different age groups. Our results suggest that in nonclinical populations, BPD may represent a complex constellation of personality traits and disturbed attachment patterns.

  20. Designing Playful Learning by Using Educational Board Game for Children in the Age Range of 7-12: (A Case Study: Recycling and Waste Separation Education Board Game)

    ERIC Educational Resources Information Center

    Mostowfi, Sara; Mamaghani, Nasser Koleini; Khorramar, Mehdi

    2016-01-01

    Due to a progressive deterioration of our planet and its resources, environmental education has become important and children are required to understand environmental issues at an early ages. So, they can cultivate the positive changes in the future. Over the past decade, many new evaluation methods have developed for evaluating user experience…

  1. 47 CFR 1.263 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Proposed findings and conclusions. 1.263... Proceedings Hearing and Intermediate Decision § 1.263 Proposed findings and conclusions. (a) Each party to the proceeding may file proposed findings of fact and conclusions, briefs, or memoranda of law: Provided,...

  2. 20 CFR 901.48 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Proposed findings and conclusions. 901.48... Termination of Enrollment § 901.48 Proposed findings and conclusions. Except in cases where the respondent has... proposed findings and conclusions and supporting reasons therefor....

  3. 47 CFR 1.263 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Proposed findings and conclusions. 1.263... Proceedings Hearing and Intermediate Decision § 1.263 Proposed findings and conclusions. (a) Each party to the proceeding may file proposed findings of fact and conclusions, briefs, or memoranda of law: Provided,...

  4. 10 CFR 2.712 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Proposed findings and conclusions. 2.712 Section 2.712... Adjudications § 2.712 Proposed findings and conclusions. (a) Any party to a proceeding may, or if directed by the presiding officer shall, file proposed findings of fact and conclusions of law, briefs and...

  5. 19 CFR 111.68 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false Proposed findings and conclusions. 111.68 Section... Monetary Penalty in Lieu of Suspension or Revocation § 111.68 Proposed findings and conclusions. The... record in which to submit proposed findings and conclusions and supporting reasons for the findings...

  6. 39 CFR 957.20 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Proposed findings and conclusions. 957.20 Section... RELATIVE TO DEBARMENT AND SUSPENSION FROM CONTRACTING § 957.20 Proposed findings and conclusions. (a) Each... the Judicial Officer such is not appropriate, submit proposed findings of fact, conclusions of law...

  7. 29 CFR 417.12 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 2 2010-07-01 2010-07-01 false Proposed findings and conclusions. 417.12 Section 417.12... findings and conclusions. Within 10 days following the close of hearings, interested persons may submit proposed findings and conclusions to the Administrative Law Judge, together with supporting...

  8. 39 CFR 957.20 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Proposed findings and conclusions. 957.20 Section... RELATIVE TO DEBARMENT AND SUSPENSION FROM CONTRACTING § 957.20 Proposed findings and conclusions. (a) Each... the Judicial Officer such is not appropriate, submit proposed findings of fact, conclusions of law...

  9. 39 CFR 3001.35 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Proposed findings and conclusions. 3001.35 Section... General Applicability § 3001.35 Proposed findings and conclusions. The Commission or the presiding officer may direct the filing of proposed findings and conclusions with a brief statement of the...

  10. 39 CFR 3001.35 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Proposed findings and conclusions. 3001.35 Section... General Applicability § 3001.35 Proposed findings and conclusions. The Commission or the presiding officer may direct the filing of proposed findings and conclusions with a brief statement of the...

  11. 39 CFR 954.18 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Proposed findings and conclusions. 954.18 Section... RELATIVE TO THE DENIAL, SUSPENSION, OR REVOCATION OF PERIODICALS MAIL PRIVILEGES § 954.18 Proposed findings and conclusions. (a) A party to a proceeding may submit proposed findings of fact and conclusions...

  12. 29 CFR 417.12 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 2 2012-07-01 2012-07-01 false Proposed findings and conclusions. 417.12 Section 417.12... findings and conclusions. Within 10 days following the close of hearings, interested persons may submit proposed findings and conclusions to the Administrative Law Judge, together with supporting...

  13. 47 CFR 1.263 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Proposed findings and conclusions. 1.263... Proceedings Hearing and Intermediate Decision § 1.263 Proposed findings and conclusions. (a) Each party to the proceeding may file proposed findings of fact and conclusions, briefs, or memoranda of law: Provided,...

  14. 39 CFR 957.20 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Proposed findings and conclusions. 957.20 Section... RELATIVE TO DEBARMENT AND SUSPENSION FROM CONTRACTING § 957.20 Proposed findings and conclusions. (a) Each... the Judicial Officer such is not appropriate, submit proposed findings of fact, conclusions of law...

  15. 47 CFR 1.263 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Proposed findings and conclusions. 1.263... Proceedings Hearing and Intermediate Decision § 1.263 Proposed findings and conclusions. (a) Each party to the proceeding may file proposed findings of fact and conclusions, briefs, or memoranda of law: Provided,...

  16. 39 CFR 954.18 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Proposed findings and conclusions. 954.18 Section... RELATIVE TO THE DENIAL, SUSPENSION, OR REVOCATION OF PERIODICALS MAIL PRIVILEGES § 954.18 Proposed findings and conclusions. (a) A party to a proceeding may submit proposed findings of fact and conclusions...

  17. 39 CFR 954.18 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Proposed findings and conclusions. 954.18 Section... RELATIVE TO THE DENIAL, SUSPENSION, OR REVOCATION OF PERIODICALS MAIL PRIVILEGES § 954.18 Proposed findings and conclusions. (a) A party to a proceeding may submit proposed findings of fact and conclusions...

  18. 19 CFR 111.68 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 1 2012-04-01 2012-04-01 false Proposed findings and conclusions. 111.68 Section... Monetary Penalty in Lieu of Suspension or Revocation § 111.68 Proposed findings and conclusions. The... record in which to submit proposed findings and conclusions and supporting reasons for the findings...

  19. 20 CFR 901.48 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Proposed findings and conclusions. 901.48... Termination of Enrollment § 901.48 Proposed findings and conclusions. Except in cases where the respondent has... proposed findings and conclusions and supporting reasons therefor....

  20. 39 CFR 954.18 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Proposed findings and conclusions. 954.18 Section... RELATIVE TO THE DENIAL, SUSPENSION, OR REVOCATION OF PERIODICALS MAIL PRIVILEGES § 954.18 Proposed findings and conclusions. (a) A party to a proceeding may submit proposed findings of fact and conclusions...

  1. 39 CFR 957.20 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Proposed findings and conclusions. 957.20 Section... RELATIVE TO DEBARMENT AND SUSPENSION FROM CONTRACTING § 957.20 Proposed findings and conclusions. (a) Each... the Judicial Officer such is not appropriate, submit proposed findings of fact, conclusions of law...

  2. 29 CFR 417.12 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 2 2013-07-01 2013-07-01 false Proposed findings and conclusions. 417.12 Section 417.12... findings and conclusions. Within 10 days following the close of hearings, interested persons may submit proposed findings and conclusions to the Administrative Law Judge, together with supporting...

  3. 47 CFR 1.263 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Proposed findings and conclusions. 1.263... Proceedings Hearing and Intermediate Decision § 1.263 Proposed findings and conclusions. (a) Each party to the proceeding may file proposed findings of fact and conclusions, briefs, or memoranda of law: Provided,...

  4. 29 CFR 417.12 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 2 2014-07-01 2014-07-01 false Proposed findings and conclusions. 417.12 Section 417.12... findings and conclusions. Within 10 days following the close of hearings, interested persons may submit proposed findings and conclusions to the Administrative Law Judge, together with supporting...

  5. 29 CFR 417.12 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 2 2011-07-01 2011-07-01 false Proposed findings and conclusions. 417.12 Section 417.12... findings and conclusions. Within 10 days following the close of hearings, interested persons may submit proposed findings and conclusions to the Administrative Law Judge, together with supporting...

  6. 39 CFR 3001.35 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Proposed findings and conclusions. 3001.35 Section... General Applicability § 3001.35 Proposed findings and conclusions. The Commission or the presiding officer may direct the filing of proposed findings and conclusions with a brief statement of the...

  7. Contact with Phenylketonurics and Their Families Beyond Pediatric Age: Conclusion from a Survey and Conference

    ERIC Educational Resources Information Center

    Fisch, Robert O.; And Others

    1977-01-01

    Twenty parents of children 12 years and older with PKU (phenylketonuria, a metabolic disorder which if untreated can result in mental retardation) were surveyed to determine their level of knowledge and their needs. (CL)

  8. Programs for Parents and Their Children in the Prenatal-Through-Three Age Range: A Child and Family Resource Program Guidance Paper.

    ERIC Educational Resources Information Center

    Dingle Associates, Inc., Washington, DC.

    This paper presents guidelines for family support programs prepared for the Child and Family Resource Program (CFRP) and other child development programs. Section I contains a brief description of the CFRP philosophy, a listing of CFRP's long range goals, detailed objectives/minimum performance standards for implementing each of these goals, and…

  9. The dynamic range of biologic functions and variation of many environmental cues may be declining in the modern age: implications for diseases and therapeutics.

    PubMed

    Yun, Anthony J; Bazar, Kimberly A; Gerber, Anthony; Lee, Patrick Y; Daniel, Stephanie M

    2005-01-01

    We hypothesize that declining dynamic range and variation of environmental cues may contribute to health dysfunctions, and that judicious expansion of biologic dynamic ranges may be beneficial. Three disparate examples involving the endocrine, autonomic, and musculoskeletal systems are discussed. Daytime sheltering, optical shading, and nighttime use of artificial light may reduce circadian luminal variation. The resulting melatonin alterations may contribute to systemic dysfunctions. Loss of temporal variation of other hormones may contribute to biologic dysfunctions, especially those involving the hypothalamic-pituitary axis. Reduced variation of physical exertion, environmental stressors, and thermal gradients that characterize modern lifestyles may reduce the autonomic dynamic range resulting in lowered heart rate variability and a myriad of systemic dysfunctions. The health benefits of activities such as exercise, meditation, acupuncture, coitus, and laughter may operate through increasing autonomic variability. Reduced physical exertion also accounts for declining dynamic range of musculoskeletal function. The resulting muscle atrophy, fat infiltration, and sarcomere shortening may not only have deleterious local effects, but may also be involved in systemic metabolic dysfunctions such as insulin resistance. The extent to which our endogenous systems rely on environmental variation for self-tuning and the impact that under-utilization of compensatory mechanisms has on biologic function are not well understood. Modern therapeutic approaches generally result in reversion to the mean of physiologic functions and may buffer against variation. For example, beta-blockers are given to reduce adrenergic excess, insulin to treat insulin insufficiency, serotonin-reuptake inhibitors for depression, and refractive lenses for myopia. By undermining the demand for native compensatory functions, such therapeutic strategies may actually impair future ability to respond to

  10. 37 CFR 251.52 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... COPYRIGHT ARBITRATION ROYALTY PANEL RULES AND PROCEDURES COPYRIGHT ARBITRATION ROYALTY PANEL RULES OF PROCEDURE Procedures of Copyright Arbitration Royalty Panels § 251.52 Proposed findings and conclusions....

  11. Zircon age range and sources of alkaline rocks from the Kurgusul intrusion, Kuznetsk Alatau: The first U-Pb (SHRIMP II) and Sm-Nd isotope data

    NASA Astrophysics Data System (ADS)

    Vrublevskii, V. V.; Gertner, I. F.; Tishin, P. A.; Bayanova, T. B.

    2014-12-01

    U-Pb isotope analysis of basic feldspathoid rocks (juvites) of the Kurgusul intrusion, NE Kuznetsk Alatau, revealed three generations of zircons of various ages (˜1.3-1.5 Ga; 484.3 ± 5.5 and 393.6 ± 9.2Ma). This suggests several stages of regional alkaline basic magmatism in the Middle Cambrian-Early Ordovician and Early-Middle Devonian and melting of the Mesoproterozoic continental crust, which form part of the basement of the Kuznetsk Alatau terrane. The trace element geochemical data indicate a continental margin setting characterized by the complex interaction of a plume-related, supra-subduction zone and crustal materials. A possible model of the magmatic evolution assumes that the ascent of a plume at the Cambrian-Ordovician boundary induced generation of the initial alkaline basaltic magmas and metasomatism and erosion of the lower lithosphere. Repeated partial melting of the lower crust after a 100 Myr period produced new magma batches of alkaline composition, which inherited zircons from the preceding episode of magma generation. The inherited juvenile magmatic source (PREMA + E-type MORB + EM) is confirmed by similarities in the Sm-Nd isotopic signatures (ɛNd( T) ≈ +4.5 to +5.7, T(Nd)DM ≈ 0.8-0.9 Ga) of derivatives of regional alkaline basic complexes of different ages.

  12. A specimen of Paralycoptera Chang & Chou 1977 (Teleostei: Osteoglossoidei) from Hong Kong (China) with a potential Late Jurassic age that extends the temporal and geographical range of the genus.

    PubMed

    Tse, Tze-Kei; Pittman, Michael; Chang, Mee-Mann

    2015-01-01

    We describe a Mesozoic fish Paralycoptera sp. (Teleostei: Osteoglossoidei), on the basis of a postcranial skeleton collected from the volcaniclastic mudstones of the Lai Chi Chong Formation of Hong Kong, China. The new finding-representing the city's first Mesozoic fish-extends the geographical distribution of Paralycoptera from eastern mainland China into Hong Kong, demonstrating a wider distribution than previously appreciated for this genus. A radiometric age for the Lai Chi Chong Formation of 146.6 ± 0.2 Ma implies a temporal range expansion for Paralycoptera of approximately 40 million years back from the Early Cretaceous (∼110 Ma). However, spores found in the Formation suggest an Early Cretaceous age that is consistent with the existing age assignment to Paralycoptera. We argue that the proposed temporal range extension is genuine because it is based on recent high precision radiometric age data, but given the discrepancies with the biostratigraphic ages further investigation is needed to confirm this. This study provides an important step towards revealing Hong Kong's Mesozoic vertebrate fauna and understanding its relationship to well-studied mainland Chinese ones.

  13. A specimen of Paralycoptera Chang & Chou 1977 (Teleostei: Osteoglossoidei) from Hong Kong (China) with a potential Late Jurassic age that extends the temporal and geographical range of the genus

    PubMed Central

    Tse, Tze-Kei; Chang, Mee-mann

    2015-01-01

    We describe a Mesozoic fish Paralycoptera sp. (Teleostei: Osteoglossoidei), on the basis of a postcranial skeleton collected from the volcaniclastic mudstones of the Lai Chi Chong Formation of Hong Kong, China. The new finding—representing the city’s first Mesozoic fish—extends the geographical distribution of Paralycoptera from eastern mainland China into Hong Kong, demonstrating a wider distribution than previously appreciated for this genus. A radiometric age for the Lai Chi Chong Formation of 146.6 ± 0.2 Ma implies a temporal range expansion for Paralycoptera of approximately 40 million years back from the Early Cretaceous (∼110 Ma). However, spores found in the Formation suggest an Early Cretaceous age that is consistent with the existing age assignment to Paralycoptera. We argue that the proposed temporal range extension is genuine because it is based on recent high precision radiometric age data, but given the discrepancies with the biostratigraphic ages further investigation is needed to confirm this. This study provides an important step towards revealing Hong Kong’s Mesozoic vertebrate fauna and understanding its relationship to well-studied mainland Chinese ones. PMID:25834774

  14. On symbolic models for Single-Conclusion Logic of Proofs

    SciTech Connect

    Krupski, Vladimir N

    2011-05-31

    In this paper we define symbolic models for Single-Conclusion Logics of Proofs. We prove the soundness and completeness of these logics with respect to the corresponding classes of symbolic models. We apply the semantic methods developed in this paper to justify the use of terms of single-conclusion logic of proofs as notation for derivations in this logic. Bibliography: 17 titles.

  15. On symbolic models for Single-Conclusion Logic of Proofs

    NASA Astrophysics Data System (ADS)

    Krupski, Vladimir N.

    2011-05-01

    In this paper we define symbolic models for Single-Conclusion Logics of Proofs. We prove the soundness and completeness of these logics with respect to the corresponding classes of symbolic models. We apply the semantic methods developed in this paper to justify the use of terms of single-conclusion logic of proofs as notation for derivations in this logic. Bibliography: 17 titles.

  16. 31 CFR 10.75 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Proposed findings and conclusions. 10... THE INTERNAL REVENUE SERVICE Rules Applicable to Disciplinary Proceedings § 10.75 Proposed findings... submit proposed findings and conclusions and their supporting reasons to the Administrative Law Judge....

  17. 31 CFR 15.737-24 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Proposed findings and conclusions. 15... EMPLOYMENT CONFLICT OF INTEREST Administrative Enforcement Proceedings § 15.737-24 Proposed findings and... afford the parties a reasonable opportunity to submit proposed findings and conclusions and...

  18. 31 CFR 10.75 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Proposed findings and conclusions. 10... THE INTERNAL REVENUE SERVICE Rules Applicable to Disciplinary Proceedings § 10.75 Proposed findings... submit proposed findings and conclusions and their supporting reasons to the Administrative Law Judge....

  19. 31 CFR 15.737-24 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Proposed findings and conclusions. 15... EMPLOYMENT CONFLICT OF INTEREST Administrative Enforcement Proceedings § 15.737-24 Proposed findings and... afford the parties a reasonable opportunity to submit proposed findings and conclusions and...

  20. 39 CFR 952.23 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Proposed findings and conclusions. 952.23 Section... RELATIVE TO FALSE REPRESENTATION AND LOTTERY ORDERS § 952.23 Proposed findings and conclusions. (a) Each... the discretion of the presiding officer such is not appropriate, submit proposed findings of...

  1. 39 CFR 952.23 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Proposed findings and conclusions. 952.23 Section... RELATIVE TO FALSE REPRESENTATION AND LOTTERY ORDERS § 952.23 Proposed findings and conclusions. (a) Each... the discretion of the presiding officer such is not appropriate, submit proposed findings of...

  2. 31 CFR 10.75 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Proposed findings and conclusions. 10... THE INTERNAL REVENUE SERVICE Rules Applicable to Disciplinary Proceedings § 10.75 Proposed findings... submit proposed findings and conclusions and their supporting reasons to the Administrative Law Judge....

  3. 29 CFR 458.87 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 2 2013-07-01 2013-07-01 false Proposed findings and conclusions. 458.87 Section 458.87... OF CONDUCT STANDARDS OF CONDUCT Hearing and Related Matters § 458.87 Proposed findings and... findings and conclusions to the Administrative Law Judge, together with supporting reasons therefor,...

  4. 10 CFR 2.712 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Proposed findings and conclusions. 2.712 Section 2.712... ORDERS Rules for Formal Adjudications § 2.712 Proposed findings and conclusions. (a) Any party to a proceeding may, or if directed by the presiding officer shall, file proposed findings of fact and...

  5. 31 CFR 10.75 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Proposed findings and conclusions. 10... THE INTERNAL REVENUE SERVICE Rules Applicable to Disciplinary Proceedings § 10.75 Proposed findings... submit proposed findings and conclusions and their supporting reasons to the Administrative Law Judge....

  6. 37 CFR 251.52 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false Proposed findings and... PROCEDURE Procedures of Copyright Arbitration Royalty Panels § 251.52 Proposed findings and conclusions. (a) Any party to the proceeding may file proposed findings of fact and conclusions, briefs, or...

  7. 31 CFR 15.737-24 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Proposed findings and conclusions. 15... EMPLOYMENT CONFLICT OF INTEREST Administrative Enforcement Proceedings § 15.737-24 Proposed findings and... afford the parties a reasonable opportunity to submit proposed findings and conclusions and...

  8. 31 CFR 8.67 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Proposed findings and conclusions. 8... THE BUREAU OF ALCOHOL, TOBACCO AND FIREARMS Disciplinary Proceedings § 8.67 Proposed findings and... afford the parties a reasonable opportunity to submit proposed findings and conclusions and...

  9. 29 CFR 458.87 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 2 2012-07-01 2012-07-01 false Proposed findings and conclusions. 458.87 Section 458.87... OF CONDUCT STANDARDS OF CONDUCT Hearing and Related Matters § 458.87 Proposed findings and... findings and conclusions to the Administrative Law Judge, together with supporting reasons therefor,...

  10. 31 CFR 8.67 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Proposed findings and conclusions. 8... THE BUREAU OF ALCOHOL, TOBACCO AND FIREARMS Disciplinary Proceedings § 8.67 Proposed findings and... afford the parties a reasonable opportunity to submit proposed findings and conclusions and...

  11. 29 CFR 458.87 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 2 2014-07-01 2014-07-01 false Proposed findings and conclusions. 458.87 Section 458.87... OF CONDUCT STANDARDS OF CONDUCT Hearing and Related Matters § 458.87 Proposed findings and... findings and conclusions to the Administrative Law Judge, together with supporting reasons therefor,...

  12. 29 CFR 458.87 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 2 2010-07-01 2010-07-01 false Proposed findings and conclusions. 458.87 Section 458.87... OF CONDUCT STANDARDS OF CONDUCT Hearing and Related Matters § 458.87 Proposed findings and... findings and conclusions to the Administrative Law Judge, together with supporting reasons therefor,...

  13. 10 CFR 2.712 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Proposed findings and conclusions. 2.712 Section 2.712... ORDERS Rules for Formal Adjudications § 2.712 Proposed findings and conclusions. (a) Any party to a proceeding may, or if directed by the presiding officer shall, file proposed findings of fact and...

  14. 39 CFR 959.22 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Proposed findings and conclusions. 959.22 Section... RELATIVE TO THE PRIVATE EXPRESS STATUTES § 959.22 Proposed findings and conclusions. (a) Each party, except... indicates in the answer that he or she does not desire to appear, may submit proposed findings of...

  15. 31 CFR 8.67 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Proposed findings and conclusions. 8... THE BUREAU OF ALCOHOL, TOBACCO AND FIREARMS Disciplinary Proceedings § 8.67 Proposed findings and... afford the parties a reasonable opportunity to submit proposed findings and conclusions and...

  16. 31 CFR 8.67 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Proposed findings and conclusions. 8... THE BUREAU OF ALCOHOL, TOBACCO AND FIREARMS Disciplinary Proceedings § 8.67 Proposed findings and... afford the parties a reasonable opportunity to submit proposed findings and conclusions and...

  17. 10 CFR 2.712 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Proposed findings and conclusions. 2.712 Section 2.712... ORDERS Rules for Formal Adjudications § 2.712 Proposed findings and conclusions. (a) Any party to a proceeding may, or if directed by the presiding officer shall, file proposed findings of fact and...

  18. 31 CFR 15.737-24 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Proposed findings and conclusions. 15... EMPLOYMENT CONFLICT OF INTEREST Administrative Enforcement Proceedings § 15.737-24 Proposed findings and... afford the parties a reasonable opportunity to submit proposed findings and conclusions and...

  19. 31 CFR 8.67 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Proposed findings and conclusions. 8... THE BUREAU OF ALCOHOL, TOBACCO AND FIREARMS Disciplinary Proceedings § 8.67 Proposed findings and... afford the parties a reasonable opportunity to submit proposed findings and conclusions and...

  20. 29 CFR 458.87 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 2 2011-07-01 2011-07-01 false Proposed findings and conclusions. 458.87 Section 458.87... OF CONDUCT STANDARDS OF CONDUCT Hearing and Related Matters § 458.87 Proposed findings and... findings and conclusions to the Administrative Law Judge, together with supporting reasons therefor,...

  1. 39 CFR 959.22 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Proposed findings and conclusions. 959.22 Section... RELATIVE TO THE PRIVATE EXPRESS STATUTES § 959.22 Proposed findings and conclusions. (a) Each party, except... indicates in the answer that he or she does not desire to appear, may submit proposed findings of...

  2. 31 CFR 10.75 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Proposed findings and conclusions. 10... THE INTERNAL REVENUE SERVICE Rules Applicable to Disciplinary Proceedings § 10.75 Proposed findings... submit proposed findings and conclusions and their supporting reasons to the Administrative Law Judge....

  3. 31 CFR 15.737-24 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Proposed findings and conclusions. 15... EMPLOYMENT CONFLICT OF INTEREST Administrative Enforcement Proceedings § 15.737-24 Proposed findings and... afford the parties a reasonable opportunity to submit proposed findings and conclusions and...

  4. 39 CFR 959.22 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Proposed findings and conclusions. 959.22 Section... RELATIVE TO THE PRIVATE EXPRESS STATUTES § 959.22 Proposed findings and conclusions. (a) Each party, except... indicates in the answer that he or she does not desire to appear, may submit proposed findings of...

  5. 39 CFR 959.22 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Proposed findings and conclusions. 959.22 Section... RELATIVE TO THE PRIVATE EXPRESS STATUTES § 959.22 Proposed findings and conclusions. (a) Each party, except... indicates in the answer that he or she does not desire to appear, may submit proposed findings of...

  6. 39 CFR 952.23 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Proposed findings and conclusions. 952.23 Section 952.23 Postal Service UNITED STATES POSTAL SERVICE PROCEDURES RULES OF PRACTICE IN PROCEEDINGS RELATIVE TO FALSE REPRESENTATION AND LOTTERY ORDERS § 952.23 Proposed findings and conclusions. (a)...

  7. Spectroscopy of asteroid pairs - new observations support previous conclusions

    NASA Astrophysics Data System (ADS)

    Polishook, David; Oszkiewicz, Dagmara Anna; None Kwiatkowski, Tomasz

    2015-08-01

    Asteroid pairs were split due to fast rotation of a strengthless body. Study them can reveal fundamental principles in asteroid interiors and evolution. We continue our spectroscopic survey of asteroid pairs in the near-IR range (IRTF) and work on completing the spectral coverage in the visible wavelength (SALT, NOT).Our new observations support our previous conclusions (Polishook et al. 2014):1. Primary and secondary members have very similar reflectance spectra supporting the claim that every pair originated from a single progenitor. We measured 2 more pairs that present the same taxonomy (4905-7813, 15107-291188). This increases to 22 the number of asteroid pairs with spectral similarities and supports the claim of a single progenitor for each pair to a significance of over 5 sigma.2. Rotational fission is not a function of the asteroid composition rather the asteroid’s structure. We present new reflectance spectra of S- and C-complex pairs that differ in their composition.3. Some asteroid pairs present spectral parameters that imply a fresh, non-weathered surface. This includes spectral slope, and a deep and wide absorption band at 1 micron. Among these, the asteroid 8306 can now be re-classified as a Q-type asteroid, a common class in the near-Earth environment, but rare in the main belt. 8306 is the 4th Q-type discovered within asteroid pairs (all locate in the main belt).4. A secondary member of an asteroid pair composed of ordinary chondrite (S-complex) might present a reflectance spectrum with lower spectral slope compared to its primary member. This is seen in the new measured reflectance spectrum of secondary 291188). This result supports the theory of Jacobson & Scheeres (2011) of continuous disintegration of the secondaries while still in the vicinity of their primaries.5. With time, the fresh surface becomes weathered. Dynamical calculations limit the disintegration time of the progenitor of the pair 4905-7813 to 1.65 millions years ago, what makes

  8. Use of cosmogenic 35S for comparing ages of water from three alpine-subalpine basins in the Colorado Front Range

    USGS Publications Warehouse

    Sueker, J.K.; Turk, J.T.; Michel, R.L.

    1999-01-01

    High-elevation basins in Colorado are a major source of water for the central and western United States; however, acidic deposition may affect the quality of this water. Water that is retained in a basin for a longer period of time may be less impacted by acidic deposition. Sulfur-35 (35S), a short-lived isotope of sulfur (t( 1/2 ) = 87 days), is useful for studying short-time scale hydrologic processes in basins where biological influences and water/rock interactions are minimal. When sulfate response in a basin is conservative, the age of water may be assumed to be that of the dissolved sulfate in it. Three alpine-subalpine basins on granitic terrain in Colorado were investigated to determine the influence of basin morphology on the residence time of water in the basins. Fern and Spruce Creek basins are glaciated and accumulate deep snowpacks during the winter. These basins have hydrologic and chemical characteristics typical of systems with rapid hydrologic response times. The age of sulfate leaving these basins, determined from the activity of 35S, averages around 200 days. In contrast, Boulder Brook basin has broad, gentle slopes and an extensive cover of surficial debris. Its area above treeline, about one-half of the basin, is blown free of snow during the winter. Variations in flow and solute concentrations in Boulder Brook are quite small compared to Fern and Spruce Creeks. After peak snowmelt, sulfate in Boulder Brook is about 200 days older than sulfate in Fern and Spruce Creeks. This indicates a substantial source of older sulfate (lacking 35S) that is probably provided from water stored in pore spaces of surficial debris in Boulder Brook basin.

  9. How do cold-sensitive species endure ice ages? Phylogeographic and paleodistribution models of postglacial range expansion of the mesothermic drought-tolerant conifer Austrocedrus chilensis.

    PubMed

    Souto, Cintia P; Kitzberger, Thomas; Arbetman, Marina P; Premoli, Andrea C

    2015-11-01

    In view of global climate change, it is important to understand the responses of tree species to climate changes in the past. Combinations of phylogeographic analysis of genetic evidence, coupled with species distribution models (SDMs), are improving our understanding on this subject. We combined SDMs and microsatellite data from populations of the entire range of Austrocedrus chilensis, a dominant mesotherm (cold-sensitive) conifer of dryland forests of the southern Andes, to test the hypothesis of long-distance postglacial migration from northern and warmer refugia at the Last Glacial Maximum (LGM). The SDM indicated suitable conditions for Austrocedrus in northern Chile (western) at the LGM and largely unsuitable conditions in Argentina (eastern). Population genetic diversity and effective population sizes within populations decreased southward along the Andes, consistent with the hypothesis of long-distance dispersal from a northern refugium. Results support the hypothesis of one (or a few) warmer (low latitude) refugia in Chile for Austrocedrus. On balance, the evidence suggests that in contrast to cold-tolerant tree taxa with the capacity to fast-track postglacial warming thanks to local refugia, cold-sensitive species might have undergone long-distance range expansion, lagging behind progressive climate change throughout the Holocene.

  10. Zirconolite, zircon and monazite-(Ce) U-Th-Pb age constraints on the emplacement, deformation and alteration history of the Cummins Range Carbonatite Complex, Halls Creek Orogen, Kimberley region, Western Australia

    NASA Astrophysics Data System (ADS)

    Downes, Peter J.; Dunkley, Daniel J.; Fletcher, Ian R.; McNaughton, Neal J.; Rasmussen, Birger; Jaques, A. Lynton; Verrall, Michael; Sweetapple, Marcus T.

    2016-04-01

    In situ SHRIMP U-Pb dating of zirconolite in clinopyroxenite from the Cummins Range Carbonatite Complex, situated in the southern Halls Creek Orogen, Kimberley region, Western Australia, has provided a reliable 207Pb/206Pb age of emplacement of 1009 ± 16 Ma. Variably metamict and recrystallised zircons from co-magmatic carbonatites, including a megacryst ~1.5 cm long, gave a range of ages from ~1043-998 Ma, reflecting partial isotopic resetting during post-emplacement deformation and alteration. Monazite-(Ce) in a strongly foliated dolomite carbonatite produced U-Th-Pb dates ranging from ~900-590 Ma. Although the monazite-(Ce) data cannot give any definitive ages, they clearly reflect a long history of hydrothermal alteration/recrystallisation, over at least 300 million years. This is consistent with the apparent resetting of the Rb-Sr and K-Ar isotopic systems by a post-emplacement thermal event at ~900 Ma during the intracratonic Yampi Orogeny. The emplacement of the Cummins Range Carbonatite Complex probably resulted from the reactivation of a deep crustal structure within the Halls Creek Orogen during the amalgamation of Proterozoic Australia with Rodinia over the period ~1000-950 Ma. This may have allowed an alkaline carbonated silicate magma that was parental to the Cummins Range carbonatites, and generated by redox and/or decompression partial melting of the asthenospheric mantle, to ascend from the base of the continental lithosphere along the lithospheric discontinuity constituted by the southern edge of the Halls Creek Orogen. There is no evidence of a link between the emplacement of the Cummins Range Carbonatite Complex and mafic large igneous province magmatism indicative of mantle plume activity. Rather, patterns of Proterozoic alkaline magmatism in the Kimberley Craton may have been controlled by changing plate motions during the Nuna-Rodinia supercontinent cycles (~1200-800 Ma).

  11. Symbolic Models for Single-Conclusion Proof Logics

    NASA Astrophysics Data System (ADS)

    Krupski, Vladimir N.

    Symbolic semantics for logics of proofs based on Mkrtychev models covers the the case of multi-conclusion proof logics. We propose symbolic models for single-conclusion proof logics (FLP and its extensions). The corresponding soundness and completeness theorems are proven. The developed symbolic model technique is used to establish the consistency of contexts required for proof internalization. In particular, we construct an extension of FLP that enjoys the strong proof internalization property with empty context.

  12. Three-micron extinction of the Titan haze in the 250-700 km altitude range: Possible evidence of a particle-aging process

    NASA Astrophysics Data System (ADS)

    Courtin, Régis; Kim, Sang Joon; Bar-Nun, Akiva

    2015-01-01

    Context. The chemical nature of the Titan haze is poorly understood. The investigation carried out by the Cassini-Huygens suite of instruments is bringing new insights into this question. Aims: This work aims at deriving the vertical variation of the spectral structure of the 3.3-3.4 μm absorption feature of the Titan haze from Cassini VIMS solar occultation data recorded between 250 and 700 km altitude. Methods: We computed the transmittance of Titan's atmosphere using a spherical shell model and a radiative transfer code including the influence of CH4, CH3D, and C2H6, as well as the effects of absorption and scattering by the haze particles. We derived the haze extinction from a comparison of the synthetic spectra with the VIMS solar occultation spectra. Results: We find a marked change in the relative amplitudes of the 3.33 and 3.38 μm features, which are characteristic of aromatic (double C=C chains or rings) or aliphatic (single C-C chains) structural groups, respectively. The pseudo-ratio of aromatics to aliphatics (uncorrected for the absolute band strengths) varies from 3.3 ± 1.9 at 580-700 km to 0.9 ± 0.1 at 350-450 km, and is 0.5 ± 0.1 around 250 km. The structural change from the aromatic to the aliphatic type between 580 and 480 km appears to correspond to a spontaneous aging of the particles - a transition between unannealed and hardened particles - while the further decrease of the pseudo-ratio of aromatics to aliphatics below 480 km may be related to the coating of the core particles by condensates such as heavy alkanes. VIMS transmission spectra data are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/573/A21

  13. Conclusiveness of natural languages and recognition of images

    SciTech Connect

    Wojcik, Z.M.

    1983-01-01

    The conclusiveness is investigated using recognition processes and one-one correspondence between expressions of a natural language and graphs representing events. The graphs, as conceived in psycholinguistics, are obtained as a result of perception processes. It is possible to generate and process the graphs automatically, using computers and then to convert the resulting graphs into expressions of a natural language. Correctness and conclusiveness of the graphs and sentences are investigated using the fundamental condition for events representation processes. Some consequences of the conclusiveness are discussed, e.g. undecidability of arithmetic, human brain assymetry, correctness of statistical calculations and operations research. It is suggested that the group theory should be imposed on mathematical models of any real system. Proof of the fundamental condition is also presented. 14 references.

  14. 40 CFR 209.35 - Conclusion of hearing.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 209.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE NOISE CONTROL ACT OF 1972 Rules of Practice Governing Hearings for Orders Issued Under Section 11(d) of the Noise Control Act § 209.35 Conclusion of hearing....

  15. 40 CFR 209.35 - Conclusion of hearing.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 209.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE NOISE CONTROL ACT OF 1972 Rules of Practice Governing Hearings for Orders Issued Under Section 11(d) of the Noise Control Act § 209.35 Conclusion of hearing....

  16. 40 CFR 209.35 - Conclusion of hearing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 209.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE NOISE CONTROL ACT OF 1972 Rules of Practice Governing Hearings for Orders Issued Under Section 11(d) of the Noise Control Act § 209.35 Conclusion of hearing....

  17. 40 CFR 209.35 - Conclusion of hearing.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 209.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE NOISE CONTROL ACT OF 1972 Rules of Practice Governing Hearings for Orders Issued Under Section 11(d) of the Noise Control Act § 209.35 Conclusion of hearing....

  18. 40 CFR 209.35 - Conclusion of hearing.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 209.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE NOISE CONTROL ACT OF 1972 Rules of Practice Governing Hearings for Orders Issued Under Section 11(d) of the Noise Control Act § 209.35 Conclusion of hearing....

  19. 39 CFR 952.23 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Proposed findings and conclusions. 952.23 Section... RELATIVE TO FALSE REPRESENTATION AND LOTTERY ORDERS (EFF. UNTIL 7-22-2011) § 952.23 Proposed findings and..., unless at the discretion of the presiding officer such is not appropriate, submit proposed findings...

  20. 20 CFR 901.48 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Proposed findings and conclusions. 901.48 Section 901.48 Employees' Benefits JOINT BOARD FOR THE ENROLLMENT OF ACTUARIES REGULATIONS GOVERNING THE... Law Judge, before making his/her decision, shall give the parties a reasonable opportunity to...

  1. When Proofs Reflect More on Assumptions than Conclusions

    ERIC Educational Resources Information Center

    Dawkins, Paul Christian

    2014-01-01

    This paper demonstrates how questions of "provability" can help students engaged in reinvention of mathematical theory to understand the axiomatic game. While proof demonstrates how conclusions follow from assumptions, "provability" characterizes the dual relation that assumptions are "justified" when they afford…

  2. Hypothesis, Prediction, and Conclusion: Using Nature of Science Terminology Correctly

    ERIC Educational Resources Information Center

    Eastwell, Peter

    2012-01-01

    This paper defines the terms "hypothesis," "prediction," and "conclusion" and shows how to use the terms correctly in scientific investigations in both the school and science education research contexts. The scientific method, or hypothetico-deductive (HD) approach, is described and it is argued that an understanding of the scientific method,…

  3. 45 CFR 672.19 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 3 2014-10-01 2014-10-01 false Proposed findings, conclusions, and order. 672.19 Section 672.19 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE... reply briefs must be submitted. All submissions shall be in writing, shall be served upon all...

  4. 45 CFR 672.19 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 3 2011-10-01 2011-10-01 false Proposed findings, conclusions, and order. 672.19 Section 672.19 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE... reply briefs must be submitted. All submissions shall be in writing, shall be served upon all...

  5. 39 CFR 912.14 - Conclusiveness of remedy.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... provisions of the Federal Tort Claims Act, shall be final and conclusive on the claimant, his agent, or legal... Postal Service UNITED STATES POSTAL SERVICE PROCEDURES PROCEDURES TO ADJUDICATE CLAIMS FOR PERSONAL INJURY OR PROPERTY DAMAGE ARISING OUT OF THE OPERATION OF THE U.S. POSTAL SERVICE § 912.14...

  6. 39 CFR 912.14 - Conclusiveness of remedy.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... provisions of the Federal Tort Claims Act, shall be final and conclusive on the claimant, his agent, or legal... Postal Service UNITED STATES POSTAL SERVICE PROCEDURES PROCEDURES TO ADJUDICATE CLAIMS FOR PERSONAL INJURY OR PROPERTY DAMAGE ARISING OUT OF THE OPERATION OF THE U.S. POSTAL SERVICE § 912.14...

  7. 39 CFR 912.14 - Conclusiveness of remedy.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... provisions of the Federal Tort Claims Act, shall be final and conclusive on the claimant, his agent, or legal... Postal Service UNITED STATES POSTAL SERVICE PROCEDURES PROCEDURES TO ADJUDICATE CLAIMS FOR PERSONAL INJURY OR PROPERTY DAMAGE ARISING OUT OF THE OPERATION OF THE U.S. POSTAL SERVICE § 912.14...

  8. 39 CFR 912.14 - Conclusiveness of remedy.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... provisions of the Federal Tort Claims Act, shall be final and conclusive on the claimant, his agent, or legal... Postal Service UNITED STATES POSTAL SERVICE PROCEDURES PROCEDURES TO ADJUDICATE CLAIMS FOR PERSONAL INJURY OR PROPERTY DAMAGE ARISING OUT OF THE OPERATION OF THE U.S. POSTAL SERVICE § 912.14...

  9. 49 CFR 511.46 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 6 2011-10-01 2011-10-01 false Proposed findings, conclusions, and order. 511.46 Section 511.46 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ADJUDICATIVE PROCEDURES Hearings §...

  10. 49 CFR 511.46 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false Proposed findings, conclusions, and order. 511.46 Section 511.46 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ADJUDICATIVE PROCEDURES Hearings §...

  11. 29 CFR 2700.65 - Proposed findings, conclusions and orders.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Proposed findings, conclusions and orders. 2700.65 Section 2700.65 Labor Regulations Relating to Labor (Continued) FEDERAL MINE SAFETY AND HEALTH REVIEW... supporting briefs. The proposals shall be served upon all parties, and shall contain adequate references...

  12. 22 CFR 18.18 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Proposed findings and conclusions. 18.18 Section 18.18 Foreign Relations DEPARTMENT OF STATE PERSONNEL REGULATIONS CONCERNING POST EMPLOYMENT CONFLICT OF INTEREST Administrative Enforcement Proceedings § 18.18 Proposed findings and...

  13. 22 CFR 18.18 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Proposed findings and conclusions. 18.18 Section 18.18 Foreign Relations DEPARTMENT OF STATE PERSONNEL REGULATIONS CONCERNING POST EMPLOYMENT CONFLICT OF INTEREST Administrative Enforcement Proceedings § 18.18 Proposed findings and...

  14. 22 CFR 18.18 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Proposed findings and conclusions. 18.18 Section 18.18 Foreign Relations DEPARTMENT OF STATE PERSONNEL REGULATIONS CONCERNING POST EMPLOYMENT CONFLICT OF INTEREST Administrative Enforcement Proceedings § 18.18 Proposed findings and...

  15. 22 CFR 18.18 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Proposed findings and conclusions. 18.18 Section 18.18 Foreign Relations DEPARTMENT OF STATE PERSONNEL REGULATIONS CONCERNING POST EMPLOYMENT CONFLICT OF INTEREST Administrative Enforcement Proceedings § 18.18 Proposed findings and...

  16. 22 CFR 18.18 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Proposed findings and conclusions. 18.18 Section 18.18 Foreign Relations DEPARTMENT OF STATE PERSONNEL REGULATIONS CONCERNING POST EMPLOYMENT CONFLICT OF INTEREST Administrative Enforcement Proceedings § 18.18 Proposed findings and...

  17. A simple dose regimen of artesunate and amodiaquine based on age or body weight range for uncomplicated falciparum malaria in children: comparison of therapeutic efficacy with standard dose regimen of artesunate and amodiaquine and artemether-lumefantrine.

    PubMed

    Gbotosho, Grace O; Sowunmi, Akintunde; Okuboyejo, Titilope M; Happi, Christian T; Folarin, Onikepe O; Adewoye, Elsie O

    2012-07-01

    A new dose regimen of artesunate and amodiaquine (NDRAA) based on age or body weight range was compared with standard dose regimen of artesunate and amodiaquine (SDRAA) calculated according to body weight and with fixed-dose artesunate-amodiaquine (FDAA) and artemether-lumefantrine (AL) in 304 children afflicted by malaria aged 15 years or younger. In initial comparison (n = 208), children on NDRAA received 1-3 times amodiaquine per kilogram of body weight and 1-1.5 times of artesunate per kilogram of body weight compared with those receiving SDRAA. Parasite but not fever clearance was significantly faster in children who received NDRAA (19.4 ± 8.4 hours vs. 24.6 ± 15.5 hours, P = 0.003). Polymerase chain reaction-uncorrected cure rates on days 28-42 were also significantly higher in children who received NDRAA (P < 0.02 in all cases). Therapeutic responses in children younger than 5 years (n = 96) treated with NDRAA, FDAA, and AL were similar. Changes in hematocrit values and reported adverse events after commencing therapy were similar in those who received NDRAA and SDRAA. All drug regimens were well tolerated. NDRAA based on age or body weight range is simple, is therapeutically superior to SDRAA calculated according to body weight, and is as efficacious as AL in children younger than 5 years.

  18. Luminescence chronology of the loess record from the Tönchesberg section - a comparison of using quartz and feldspar as dosimeter to extend the age range beyond the Eemian

    NASA Astrophysics Data System (ADS)

    Dorothe Schmidt, Esther; Frechen, Manfred; Murray, Andrew S.; Tsukamoto, Sumiko

    2010-05-01

    The loess-paleosol sequences of the Tönchesberg section, located in the East Eifel Volcanic field (Germany) provide an excellent climate archive of the late Middle and the Upper Pleistocene in the Middle Rhine area. Loess deposits from the last Glacial (Würmian) and the penultimate Glacial (Rissian) are up to 12 m and 15 m thick, respectively, and intercalated by palaeosols. Optically stimulated luminescence (OSL), thermally transferred optically stimulated luminescence (TT-OSL) and infrared stimulated luminescence (IRSL) measurements were carried out on 14 samples from the Tönchesberg section to determine the deposition age and to set up a more reliable chronological framework for the penultimate and last interglacial-glacial cycle. The fine-grained quartz OSL and polymineral IRSL ages are in good agreement with each other and also with the geologically estimated age, but the quartz TT-OSL ages are overestimated. The OSL and IRSL ages range from 16.8 ± 1.2 to 189 ± 16 ka indicating that the youngest loess and the weakly developed soils were deposited during marine isotope stage (MIS) 2 and 3 and that the two marker loess were most likely accumulated in the transition MIS 4/5. Loess and reworked loess postdating the Eemian soil yield ages of 110-115 ka indicating that these deposits very likely correlate to MIS 5d. Loess deposits taken below the Eemian soil are attributed to the transition MIS 6/7. A weakly developed soil above the Tönchesberg scoria yield an age of 189 ± 16 ka indicating an interstadial soil formation during MIS 7. This is in good agreement with preliminary 40Ar/39Ar-ages for the Tönchesberg scoria and the intercalated tephra layers. Reliable age estimates up to ~70 ka could be obtained using quartz OSL and up to ~190 ka using the pulsed post-IR IR signal from feldspar. Hence the infrared stimulated luminescence (IRSL) is considered as the best approach to date the loess from the Middle Rhine area > 70 ka.

  19. Statistical Conclusion Validity: Some Common Threats and Simple Remedies

    PubMed Central

    García-Pérez, Miguel A.

    2012-01-01

    The ultimate goal of research is to produce dependable knowledge or to provide the evidence that may guide practical decisions. Statistical conclusion validity (SCV) holds when the conclusions of a research study are founded on an adequate analysis of the data, generally meaning that adequate statistical methods are used whose small-sample behavior is accurate, besides being logically capable of providing an answer to the research question. Compared to the three other traditional aspects of research validity (external validity, internal validity, and construct validity), interest in SCV has recently grown on evidence that inadequate data analyses are sometimes carried out which yield conclusions that a proper analysis of the data would not have supported. This paper discusses evidence of three common threats to SCV that arise from widespread recommendations or practices in data analysis, namely, the use of repeated testing and optional stopping without control of Type-I error rates, the recommendation to check the assumptions of statistical tests, and the use of regression whenever a bivariate relation or the equivalence between two variables is studied. For each of these threats, examples are presented and alternative practices that safeguard SCV are discussed. Educational and editorial changes that may improve the SCV of published research are also discussed. PMID:22952465

  20. Conclusive evidence for panmixia in the American eel.

    PubMed

    Pujolar, Jose M

    2013-04-01

    Eels are unique species in the biological world. The two North Atlantic eel species, the American eel (Anguilla rostrata) and the European eel (A. anguilla), occupy a broad range of habitats from the Caribbean to Greenland in the western Atlantic and from Morocco to Iceland in the eastern Atlantic, respectively. North Atlantic eels have a catadromous life cycle, spawning only in the Sargasso Sea and spending the majority of their lives in continental (fresh, brackish and coastal) waters. Despite such a wide distribution range, North Atlantic eels have been regarded as a textbook example of panmictic species. In contrast with the large amount of population genetic studies testing the panmixia hypothesis in the European eel, a relatively modest effort has been given to study the population structure of the American eel. In this issue of Molecular Ecology, C^ote et al. (2013) present the most comprehensive American eel data set to date, which includes samples of different life stages obtained throughout all its distribution range in North America. Results show a total lack of genetic differentiation among samples and provide decisive evidence for panmixia in the American eel.

  1. Conclusive evidence for panmixia in the American eel.

    PubMed

    Pujolar, Jose M

    2013-04-01

    Eels are unique species in the biological world. The two North Atlantic eel species, the American eel (Anguilla rostrata) and the European eel (A. anguilla), occupy a broad range of habitats from the Caribbean to Greenland in the western Atlantic and from Morocco to Iceland in the eastern Atlantic, respectively. North Atlantic eels have a catadromous life cycle, spawning only in the Sargasso Sea and spending the majority of their lives in continental (fresh, brackish and coastal) waters. Despite such a wide distribution range, North Atlantic eels have been regarded as a textbook example of panmictic species. In contrast with the large amount of population genetic studies testing the panmixia hypothesis in the European eel, a relatively modest effort has been given to study the population structure of the American eel. In this issue of Molecular Ecology, C^ote et al. (2013) present the most comprehensive American eel data set to date, which includes samples of different life stages obtained throughout all its distribution range in North America. Results show a total lack of genetic differentiation among samples and provide decisive evidence for panmixia in the American eel. PMID:23620904

  2. Conclusive identification of quantum channels via monogamy of quantum correlations

    NASA Astrophysics Data System (ADS)

    Kumar, Asutosh; Singha Roy, Sudipto; Pal, Amit Kumar; Prabhu, R.; Sen(De), Aditi; Sen, Ujjwal

    2016-10-01

    We investigate the action of global noise and local channels, namely, amplitude-damping, phase-damping, and depolarizing channels, on monogamy of quantum correlations, such as negativity and quantum discord, in three-qubit systems. We discuss the monotonic and non-monotonic variation, and robustness of the monogamy scores. By using monogamy scores, we propose a two-step protocol to conclusively identify the noise applied to the quantum system, by using generalized Greenberger-Horne-Zeilinger and generalized W states as resource states. We discuss a possible generalization of the results to higher number of parties.

  3. [Outline of political conclusions of multiple regressions: integrants and problems].

    PubMed

    Dixon, R B

    1978-01-01

    In this article the author criticizes the methodology and the findings of an article by Mauldin and Berelson which appeared in 1978 in Studies in Family Planning about population decrease in developing countries and about its implications on population policies. According to the author that article did not take into consideration: 1) the fact that socioeconomic conditions in a given country are more important than family planning programs for a decrease in fertility rate; 2) the fact that it is not known which kinds of family planning programs are more effective, and which kind of social level is more conducive to fertility decrease; and, 3) the status and educational level of women in the countries studied. In conclusion, the author states that the findings of Mauldin and Berelson, although interesting, imply arbitrary procedures and statistics, and cannot be used for the purpose of population policy.

  4. Equipment qualification risk scoping analyses: Results and conclusions

    SciTech Connect

    Bustard, L.D.; Kolaczkowski, A.M.

    1989-01-01

    Probabilistic risk assessment (PRA) techniques and insights have been employed during an investigation entitled the Equipment Qualification (EQ)-Risk Scoping Study to assess the risk significance of equipment qualification issues. This approach for evaluating EQ issues suggests that some issues are not risk significant while some have a significant potential to increase risk. For example, EQ issues associated with long term accident equipment operability are not risk significant. Alternatively, there are selected system operations that require equipment not qualified for important accident environments. Though the study demonstrated that PRA does provide insights that modify perceptions regarding the importance of various EQ issues, it should be noted that PRA methods currently cannot define the risk significance for some EQ issues. Additional discussion regarding the study's results and conclusions is provided. 6 refs.

  5. Conclusive quantum steering with superconducting transition edge sensors

    NASA Astrophysics Data System (ADS)

    de Almeida, Marcelo P.; Smith, Devin H.; Gillett, Geo; Branciard, Cyril; Fedrizzi, Alessandro; Weinhold, Till J.; Lita, Adriana; Calkins, Brice; Gertis, Thomas; Nam, Sae Woo; White, Andrew G.

    2012-02-01

    Quantum steering allows two parties to verify shared entanglement even if one measurement device is untrusted. A conclusive demonstration of steering through the violation of a steering inequality is of considerable fundamental interest and opens up applications in quantum communication. To date all experimental tests with single photon states have relied on post-selection, allowing untrusted devices to cheat by hiding unfavorable events in losses. Here we close this ``detection loophole'' by combining a highly efficient source of entangled photon pairs with superconducting transition edge sensors. We achieve an unprecedented ˜62% conditional detection efficiency of entangled photons and violate a steering inequality with the minimal number of measurement settings by 48 standard deviations. Our results provide a clear path to practical applications of steering and to a photonic loophole-free Bell test.

  6. Conclusive quantum steering with superconducting transition-edge sensors

    NASA Astrophysics Data System (ADS)

    Smith, Devin H.; Gillett, Geoff; de Almeida, Marcelo P.; Branciard, Cyril; Fedrizzi, Alessandro; Weinhold, Till J.; Lita, Adriana; Calkins, Brice; Gerrits, Thomas; Wiseman, Howard M.; Nam, Sae Woo; White, Andrew G.

    2012-01-01

    Quantum steering allows two parties to verify shared entanglement even if one measurement device is untrusted. A conclusive demonstration of steering through the violation of a steering inequality is of considerable fundamental interest and opens up applications in quantum communication. To date, all experimental tests with single-photon states have relied on post selection, allowing untrusted devices to cheat by hiding unfavourable events in losses. Here we close this 'detection loophole' by combining a highly efficient source of entangled photon pairs with superconducting transition-edge sensors. We achieve an unprecedented ~62% conditional detection efficiency of entangled photons and violate a steering inequality with the minimal number of measurement settings by 48 s.d.s. Our results provide a clear path to practical applications of steering and to a photonic loophole-free Bell test.

  7. Parenteral trace element provision: recent clinical research and practical conclusions.

    PubMed

    Stehle, P; Stoffel-Wagner, B; Kuhn, K S

    2016-08-01

    The aim of this systematic review (PubMed, www.ncbi.nlm.nih.gov/pubmed and Cochrane, www.cochrane.org; last entry 31 December 2014) was to present data from recent clinical studies investigating parenteral trace element provision in adult patients and to draw conclusions for clinical practice. Important physiological functions in human metabolism are known for nine trace elements: selenium, zinc, copper, manganese, chromium, iron, molybdenum, iodine and fluoride. Lack of, or an insufficient supply of, these trace elements in nutrition therapy over a prolonged period is associated with trace element deprivation, which may lead to a deterioration of existing clinical symptoms and/or the development of characteristic malnutrition syndromes. Therefore, all parenteral nutrition prescriptions should include a daily dose of trace elements. To avoid trace element deprivation or imbalances, physiological doses are recommended. PMID:27049031

  8. The critical wetting saga: how to draw the correct conclusion

    NASA Astrophysics Data System (ADS)

    Parry, A. O.; Rascón, C.; Bernardino, N. R.; Romero-Enrique, J. M.

    2008-12-01

    A long-standing problem in condensed matter physics concerns the nature of the critical wetting phase transition in the Ising model or, more generally, in 3D systems with short-ranged forces. This is of fundamental interest because 3D corresponds to the upper critical dimension of the transition and it is not clear a priori whether the behaviour of the system will be mean-field-like or fluctuation-dominated. Renormalization group studies of the standard coarse-grained effective interfacial Hamiltonian model famously predict strong non-universal critical exponents which depend on the value of the so-called wetting parameter ω. However, these predictions are at odds with extensive Monte Carlo simulations of wetting in the Ising model, due to Binder, Landau and coworkers, which appear to be more mean-field-like. Further amendments to the interfacial Hamiltonian, which included the presence of a position-dependent stiffness, worsened the problem by paradoxically predicting fluctuation-induced first-order wetting behaviour. Here we show from re-analysis of a microscopic Landau-Ginzburg-Wilson model of 3D short-ranged wetting that correlation functions are characterized by two diverging parallel length scales, not one, as previously thought. This has a simple diagrammatic explanation using a non-local interfacial Hamiltonian and yields a thermodynamically consistent theory of wetting in keeping with exact sum rules. The non-local model crucially contains long-ranged two-body interfacial interactions, characterized by the new length scale, which were missing in earlier treatments. For critical wetting the second length cuts off the spectrum of interfacial fluctuations determining the repulsion from the wall. We show how this corrects previous renormalization group predictions for fluctuation effects, based on local interfacial Hamiltonians. In particular, lowering the cut-off leads to a substantial reduction in the effective value of the wetting parameter controlling the

  9. Broad Consent For Research With Biological Samples: Workshop Conclusions

    PubMed Central

    Grady, Christine; Eckstein, Lisa; Berkman, Ben; Brock, Dan; Cook-Deegan, Robert; Fullerton, Stephanie M.; Greely, Hank; Hansson, Mats G.; Hull, Sara; Kim, Scott; Lo, Bernie; Pentz, Rebecca; Rodriguez, Laura; Weil, Carol; Wilfond, Benjamin S.; Wendler, David

    2016-01-01

    Different types of consent are used to obtain human biospecimens for future research. This variation has resulted in confusion regarding what research is permitted, inadvertent constraints on future research, and research proceeding without consent. The NIH Clinical Center’s Department of Bioethics held a workshop to consider the ethical acceptability of addressing these concerns by using broad consent for future research on stored biospecimens. Multiple bioethics scholars, who have written on these issues, discussed the reasons for consent, the range of consent strategies, gaps in our understanding, and concluded with a proposal for broad initial consent coupled with oversight and, when feasible, ongoing provision of information to donors. The manuscript describes areas of agreement as well as areas that need more research and dialogue. Given recent proposed changes to the Common Rule, and new guidance regarding storing and sharing data and samples, this is an important and timely topic. PMID:26305750

  10. Jumping to conclusions and the continuum of delusional beliefs.

    PubMed

    Warman, Debbie M; Lysaker, Paul H; Martin, Joel M; Davis, Louanne; Haudenschield, Samantha L

    2007-06-01

    The present study examined the jumping to conclusions reasoning bias across the continuum of delusional ideation by investigating individuals with active delusions, delusion prone individuals, and non-delusion prone individuals. Neutral and highly self-referent probabilistic reasoning tasks were employed. Results indicated that individuals with delusions gathered significantly less information than delusion prone and non-delusion prone participants on both the neutral and self-referent tasks, (p<.001). Individuals with delusions made less accurate decisions than the delusion prone and non-delusion prone participants on both tasks (p<.001), yet were more confident about their decisions than were delusion prone and non-delusion prone participants on the self-referent task (p=.002). Those with delusions and those who were delusion prone reported higher confidence in their performance on the self-referent task than they did the neutral task (p=.02), indicating that high self-reference impacted information processing for individuals in both of these groups. The results are discussed in relation to previous research in the area of probabilistic reasoning and delusions. PMID:17052687

  11. The harms of enhancement and the conclusive reasons view.

    PubMed

    Douglas, Thomas

    2015-01-01

    Many critics of bioenhancement go to considerable lengths to establish the existence of reasons against pursuing bioenhancements but do little to establish the absence of reasons in favor. This suggests that they accept what Allen Buchanan has called the conclusive reasons view (CRV). According to this view, our reasons against bioenhancement are obviously decisive, so there is no need to balance them against countervailing reasons. Buchanan criticizes the CRV by showing that the reasons most commonly adduced against bioenhancement are not decisive, or, at least, not obviously so. In this article, I suggest that both Buchanan and the authors to whom he is responding underestimate the strength of the case for the CRV. There are, I argue, harm-based reasons against bioenhancement that provide stronger support to the CRV than the reasons that have most often been adduced by critics of enhancement. However, I then argue that even these harm-based reasons are not obviously decisive. Thus, I ultimately agree with Buchanan about the falsity of the CRV, though I disagree with him about the reasons for its falsity.

  12. Killing Range

    PubMed Central

    Asal, Victor; Rethemeyer, R. Karl; Horgan, John

    2015-01-01

    This paper presents an analysis of the Provisional Irish Republican Army's (PIRA) brigade level behavior during the Northern Ireland Conflict (1970-1998) and identifies the organizational factors that impact a brigade's lethality as measured via terrorist attacks. Key independent variables include levels of technical expertise, cadre age, counter-terrorism policies experienced, brigade size, and IED components and delivery methods. We find that technical expertise within a brigade allows for careful IED usage, which significantly minimizes civilian casualties (a specific strategic goal of PIRA) while increasing the ability to kill more high value targets with IEDs. Lethal counter-terrorism events also significantly affect a brigade's likelihood of killing both civilians and high-value targets but in different ways. Killing PIRA members significantly decreases IED fatalities but also significantly decreases the possibility of zero civilian IED-related deaths in a given year. Killing innocent Catholics in a Brigade's county significantly increases total and civilian IED fatalities. Together the results suggest the necessity to analyze dynamic situational variables that impact terrorist group behavior at the sub-unit level. PMID:25838603

  13. Collaborative Automation Reliably Remediating Erroneous Conclusion Threats (CARRECT)

    PubMed Central

    Lansey, Jonathan C.; Picciano, Paul; Yohai, Ian; Grant, Fred; Gern, Robert

    2013-01-01

    Objective The objective of the CARRECT software is to make cutting edge statistical methods for reducing bias in epidemiological studies easy to use and useful for both novice and expert users. Introduction Analyses produced by epidemiologists and public health practitioners are susceptible to bias from a number of sources including missing data, confounding variables, and statistical model selection. It often requires a great deal of expertise to understand and apply the multitude of tests, corrections, and selection rules, and these tasks can be time-consuming and burdensome. To address this challenge, Aptima began development of CARRECT, the Collaborative Automation Reliably Remediating Erroneous Conclusion Threats system. When complete, CARRECT will provide an expert system that can be embedded in an analyst’s workflow. CARRECT will support statistical bias reduction and improved analyses and decision making by engaging the user in a collaborative process in which the technology is transparent to the analyst. Methods Older approaches to imputing missing data, including mean imputation and single imputation regression methods, have steadily given way to a class of methods known as “multiple imputation” (hereafter “MI”; Rubin 1987). Rather than making the restrictive assumption that the data are missing completely at random (MCAR), MI typically assumes the data are missing at random (MAR). There are two key innovations behind MI. First, the observed values can be useful in predicting the missing cells, and thus specifying a joint distribution of the data is the first step in implementing the models. Second, single imputation methods will likely fail not only because of the inherent uncertainty in the missing values but also because of the estimation uncertainty associated with generating the parameters in the imputation procedure itself. By contrast, drawing the missing values multiple times, thereby generating m complete datasets along with the

  14. Waste dislodging and conveyance testing summary and conclusions to date

    SciTech Connect

    Rinker, M.W.; Hatchell, B.K.; Mullen, O.D.

    1994-09-01

    This document summarizes recent work performed by the Waste Dislodging and Conveyance technology development program to provide assistance with the retrieval of wastes from the Hanford single-shell tanks (SSTs). This work is sponsored by the Underground Storage Tank-Integrated Demonstration (UST-ID) Office with the U.S. Department of Energy (DOE) Office of Technology Development. A baseline technology of high-pressure water-jet dislodging and pneumatic conveyance integrated as a scarifier is proposed as a means of retrieval. The tests and studies described were performed to demonstrate that at least one robust technology exists that could be effectively used with low water-addition arm-based systems. These results are preliminary and do not represent an optimized baseline. The Waste Dislodging and Conveyance work thus far has demonstrated that waterjet mobilization and air conveyance can mobilize and convey SST waste simulants at the target rates while operating within the space envelope and the dynamic loading constraints of deployment devices. The recommended technologies are well proven in industrial applications and are quite robust, yet lightweight and relatively benign to the retrieval environment. The baseline approach has versatility to continuously dislodge and convey a broad range of waste forms, from hard wastes to soft sludge wastes. The approach also has the major advantage of being noncontact with the waste surface under normal operation.

  15. Acrylamide monitoring in Switzerland, 2007-2009: results and conclusions.

    PubMed

    Biedermann, M; Grundbock, F; Fiselier, K; Biedermann, S; Burgi, C; Grob, K

    2010-10-01

    Parallel to the European Union acrylamide monitoring for the years 2007-2009, Switzerland performed its own monitoring, covering the whole range of products that significantly contain acrylamide (almost 300 samples per year), but focusing on those products that may result in high exposure. As reducing sugars are critical for potato products, these were included. No significant change, particularly improvement, was noticed, especially regarding those products for which substantial potential for improvement is known. 'Western-style' French fries continued to contain some four times more reducing sugars than 'traditional' fries, with correspondingly higher acrylamide in the finished product. The supply of raw potatoes low in reducing sugars by retail shops needs improvement, but there seemed to be insufficient willingness on a voluntary basis. A foreign producer was successful in penetrating the Swiss market with special potato chips containing up to 7000 microg kg(-1) acrylamide and only harsh measures could stop this. Three of about 61 products in the group of bakery ware showed a marked improvement. But there was also a store brand cracker that competed with a leading brand which contained 15 times more acrylamide (845 microg kg(-1)). Cereals contained 1080 microg kg(-1) acrylamide and even a warning did not prompt the producer to sell substantially better products one year later. It seems that only measures by the authorities will achieve improvements. The following seem promising: a limit for reducing sugars in prefabricates for French fries; the improved supply of raw potatoes low in sugars for roasting and frying; a legal limit for acrylamide content in potato chips; a general provision that products must not contain substantially more acrylamide than achievable by good manufacturing practice; and fryers with a temperature profile from an initial high to a lower final value.

  16. Acrylamide monitoring in Switzerland, 2007-2009: results and conclusions.

    PubMed

    Biedermann, M; Grundbock, F; Fiselier, K; Biedermann, S; Burgi, C; Grob, K

    2010-10-01

    Parallel to the European Union acrylamide monitoring for the years 2007-2009, Switzerland performed its own monitoring, covering the whole range of products that significantly contain acrylamide (almost 300 samples per year), but focusing on those products that may result in high exposure. As reducing sugars are critical for potato products, these were included. No significant change, particularly improvement, was noticed, especially regarding those products for which substantial potential for improvement is known. 'Western-style' French fries continued to contain some four times more reducing sugars than 'traditional' fries, with correspondingly higher acrylamide in the finished product. The supply of raw potatoes low in reducing sugars by retail shops needs improvement, but there seemed to be insufficient willingness on a voluntary basis. A foreign producer was successful in penetrating the Swiss market with special potato chips containing up to 7000 microg kg(-1) acrylamide and only harsh measures could stop this. Three of about 61 products in the group of bakery ware showed a marked improvement. But there was also a store brand cracker that competed with a leading brand which contained 15 times more acrylamide (845 microg kg(-1)). Cereals contained 1080 microg kg(-1) acrylamide and even a warning did not prompt the producer to sell substantially better products one year later. It seems that only measures by the authorities will achieve improvements. The following seem promising: a limit for reducing sugars in prefabricates for French fries; the improved supply of raw potatoes low in sugars for roasting and frying; a legal limit for acrylamide content in potato chips; a general provision that products must not contain substantially more acrylamide than achievable by good manufacturing practice; and fryers with a temperature profile from an initial high to a lower final value. PMID:20730646

  17. Highlights and Conclusions of the Unidata OGC Interoperability Day

    NASA Astrophysics Data System (ADS)

    Domenico, B.; Davis, E.; Rew, R.; Caron, J.; Nativi, S.; Yang, W.; Falke, S.; Woolf, A.; Tandy, J.

    2007-12-01

    At the OGC (Open Geospatial Consortium) Technical Committee meetings, Unidata hosted a special Interoperability Day workshop to address the use of web services via standard interfaces for accessing a broad range of environmental data. These interfaces include: WCS (Web Coverage Service), WFS (Web Feature Service, SOS (Sensor Observation Service, CS-W/ebRIM (Catalog Service for the Web / electronic business Registry Information Model) for providing access to data currently served via THREDDS (THematic Real-time Environmental Distributed Data Services), OPeNDAP (Open source Project for a Network Data Access Protocol), netCDF-CF (network Common Data Form - Climate and Forecast conventions) and IDD/LDM (Internet Data Distribution / Local Data Manager) technologies. The primary data served includes weather, climate and ocean data from the community sometimes referred to as Fluid Earth Sciences (FES). An international set of representatives from industry, government, and academia, spanning many geosciences disciplines participated actively in the workshop and are committed to continued collaboration. The overall objective for the day was to come up with practical and concrete ideas for how to deliver various classes of FES data via web services through the standard interfaces. The primary focus was on gridded datasets (e.g., forecast model output) and station/observation/point datasets (e.g. the observational data collected at weather stations, ocean buoys, river gaging stations. As time allowed, other categories (profile/trajectory, swath, radial, unstructured grids) were addressed. The main objective was to come up with a realistic plan for dealing with gridded and station/observation/point datasets. Then the remaining categories can be addressed incrementally. This presentation summarizes the highlights of the Interoperability Day and the resulting plans for future implementation and testing.

  18. Cosmological Gamma-Ray Bursts and Hypernovae Conclusively Linked

    NASA Astrophysics Data System (ADS)

    2003-06-01

    Clearest-Ever Evidence from VLT Spectra of Powerful Event Summary A very bright burst of gamma-rays was observed on March 29, 2003 by NASA's High Energy Transient Explorer (HETE-II) , in a sky region within the constellation Leo. Within 90 min, a new, very bright light source (the "optical afterglow") was detected in the same direction by means of a 40-inch telescope at the Siding Spring Observatory (Australia) and also in Japan. The gamma-ray burst was designated GRB 030329 , according to the date. And within 24 hours, a first, very detailed spectrum of this new object was obtained by the UVES high-dispersion spectrograph on the 8.2-m VLT KUEYEN telescope at the ESO Paranal Observatory (Chile). It allowed to determine the distance as about 2,650 million light-years (redshift 0.1685). Continued observations with the FORS1 and FORS2 multi-mode instruments on the VLT during the following month allowed an international team of astronomers [1] to document in unprecedented detail the changes in the spectrum of the optical afterglow of this gamma-ray burst . Their detailed report appears in the June 19 issue of the research journal "Nature". The spectra show the gradual and clear emergence of a supernova spectrum of the most energetic class known, a "hypernova" . This is caused by the explosion of a very heavy star - presumably over 25 times heavier than the Sun. The measured expansion velocity (in excess of 30,000 km/sec) and the total energy released were exceptionally high, even within the elect hypernova class. From a comparison with more nearby hypernovae, the astronomers are able to fix with good accuracy the moment of the stellar explosion. It turns out to be within an interval of plus/minus two days of the gamma-ray burst. This unique conclusion provides compelling evidence that the two events are directly connected. These observations therefore indicate a common physical process behind the hypernova explosion and the associated emission of strong gamma

  19. The Alaska earthquake, March 27, 1964: lessons and conclusions

    USGS Publications Warehouse

    Eckel, Edwin B.

    1970-01-01

    local waves. Better earthquake-hazard maps, based on improved knowledge of regional geology, fault behavior, and earthquake mechanisms, are needed for the entire country. Their preparation will require the close collaboration of engineers, seismologists, and geologists. Geologic maps of all inhabited places in earthquake-prone parts of the country are also needed by city planners and others, because the direct relationship between local geology and potential earthquake damage is now well understood. Improved and enlarged nets of earthquake-sensing instruments, sited in relation to known geology, are needed, as are many more geodetic and hydrographic measurements. Every large earthquake, wherever located, should be regarded as a full-scale laboratory experiment whose study can give scientific and engineering information unobtainable from any other source. Plans must be made before the event to insure staffing, funding, and coordination of effort for the scientific and engineering study of future earthquakes. Advice of earth scientists and engineers should be used in the decision-making processes involved in reconstruction after any future disastrous earthquake, as was done after the Alaska earthquake. The volume closes with a selected bibliography and a comprehensive index to the entire series of U.S. Geological Survey Professional Papers 541-546. This is the last in a series of six reports that the U.S. Geological Survey published on the results of a comprehensive geologic study that began, as a reconnaissance survey, within 24 hours after the March 27, 1964, Magnitude 9.2 Great Alaska Earthquake and extended, as detailed investigations, through several field seasons. The 1964 Great Alaska earthquake was the largest earthquake in the U.S. since 1700. Professional Paper 546, in 1 part, describes Lessons and Conclusions.

  20. Aging gauge

    DOEpatents

    Betts, Robert E.; Crawford, John F.

    1989-01-01

    An aging gauge comprising a container having a fixed or a variable sized t opening with a cap which can be opened to control the sublimation rate of a thermally sublimational material contained within the container. In use, the aging gauge is stored with an item to determine total heat the item is subjected to and also the maximum temperature to which the item has been exposed. The aging gauge container contains a thermally sublimational material such as naphthalene or similar material which has a low sublimation rate over the temperature range from about 70.degree. F. to about 160.degree. F. The aging products determined by analyses of a like item aged along with the aging gauge for which the sublimation amount is determined is employed to establish a calibration curve for future aging evaluation. The aging gauge is provided with a means for determining the maximum temperature exposure (i.e., a thermally indicating material which gives an irreversible color change, Thermocolor pigment). Because of the relationship of doubling reaction rates for increases of 10.degree. C., equivalency of item used in accelerated aging evaluation can be obtained by referring to a calibration curve depicting storage temperature on the abscissa scale and multiplier on the ordinate scale.

  1. Aging gauge

    DOEpatents

    Betts, Robert E.; Crawford, John F.

    1989-04-04

    An aging gauge comprising a container having a fixed or a variable sized t opening with a cap which can be opened to control the sublimation rate of a thermally sublimational material contained within the container. In use, the aging gauge is stored with an item to determine total heat the item is subjected to and also the maximum temperature to which the item has been exposed. The aging gauge container contains a thermally sublimational material such as naphthalene or similar material which has a low sublimation rate over the temperature range from about 70.degree. F. to about 160.degree. F. The aging products determined by analyses of a like item aged along with the aging gauge for which the sublimation amount is determined is employed to establish a calibration curve for future aging evaluation. The aging gauge is provided with a means for determining the maximum temperature exposure (i.e., a thermally indicating material which gives an irreversible color change, Thermocolor pigment). Because of the relationship of doubling reaction rates for increases of 10.degree. C., equivalency of item used in accelerated aging evaluation can be obtained by referring to a calibration curve depicting storage temperature on the abscissa scale and multiplier on the ordinate scale.

  2. Home range and travels

    USGS Publications Warehouse

    Stickel, L.F.; King, John A.

    1968-01-01

    The concept of home range was expressed by Seton (1909) in the term 'home region,' which Burr (1940, 1943) clarified with a definition of home range and exemplified in a definitive study of Peromyscus in the field. Burt pointed out the ever-changing characteristics of home-range area and the consequent absence of boundaries in the usual sense--a finding verified by investigators thereafter. In the studies summarized in this paper, sizes of home ranges of Peromyscus varied within two magnitudes, approximately from 0.1 acre to ten acres, in 34 studies conducted in a variety of habitats from the seaside dunes of Florida to the Alaskan forests. Variation in sizes of home ranges was correlated with both environmental and physiological factors; with habitat it was conspicuous, both in the same and different regions. Food supply also was related to size of home range, both seasonally and in relation to habitat. Home ranges generally were smallest in winter and largest in spring, at the onset of the breeding season. Activity and size also were affected by changes in weather. Activity was least when temperatures were low and nights were bright. Effects of rainfall were variable. Sizes varied according to sex and age; young mice remained in the parents' range until they approached maturity, when they began to travel more widely. Adult males commonly had larger home ranges than females, although there were a number of exceptions. An inverse relationship between population density and size of home range was shown in several studies and probably is the usual relationship. A basic need for activity and exploration also appeared to influence size of home range. Behavior within the home range was discussed in terms of travel patterns, travels in relation to home sites and refuges, territory, and stability of size of home range. Travels within the home range consisted of repeated use of well-worn trails to sites of food, shelter, and refuge, plus more random exploratory travels

  3. Bone age in cerebral palsy

    PubMed Central

    Miranda, Eduardo Régis de Alencar Bona; Palmieri, Maurício D'arc; de Assumpção, Rodrigo Montezuma César; Yamada, Helder Henzo; Rancan, Daniela Regina; Fucs, Patrícia Maria de Moraes Barros

    2013-01-01

    Objective To compare the chronological age and bone age among cerebral palsy patients in the outpatient clinic and its correlation with the type of neurological involvement, gender and functional status. Methods 401 patients with spastic cerebral palsy, and ages ranging from three months to 20 years old, submitted to radiological examination for bone age and analyzed by two independent observers according Greulich & Pyle. Results In the topographic distribution, there was a significant delay (p<0.005) in tetraparetic (17.7 months), hemiparetic (10.1 months), and diparetic patients (7.9 months). In the hemiparetic group, the mean bone age in the affected side was 96.88 months and the uncompromised side was 101.13 months (p<0.005). Regarding functional status, the ambulatory group showed a delay of 18.73 months in bone age (p<0.005). Comparing bone age between genders, it was observed a greater delay in males (13.59 months) than in females (9.63 months), but not statistically significant (p = 0.54). Conclusion There is a delay in bone age compared to chronological age influenced by the topography of spasticity, functional level and gender in patients with cerebral palsy. Level of Evidence IV, Case Series. PMID:24453693

  4. Incorrect statistical method in parallel-groups RCT led to unsubstantiated conclusions.

    PubMed

    Allison, David B; Antoine, Lisa H; George, Brandon J

    2016-01-01

    The article by Aiso et al. titled "Compared with the intake of commercial vegetable juice, the intake of fresh fruit and komatsuna (Brassica rapa L. var perviridis) juice mixture reduces serum cholesterol in middle-aged men: a randomized controlled pilot study" does not meet the expected standards of Lipids in Health and Disease. Although the article concludes that there are some significant benefits to their komatsuna juice mixture, these claims are not supported by the statistical analyses used. An incorrect procedure was used to compare the differences in two treatment groups over time, and a large number of outcomes were tested without correction; both issues are known to produce high rates of false positives, making the conclusions of the study unjustified. The study also fails to follow published journal standards regarding clinical trial registration and reporting.

  5. Incorrect statistical method in parallel-groups RCT led to unsubstantiated conclusions.

    PubMed

    Allison, David B; Antoine, Lisa H; George, Brandon J

    2016-01-01

    The article by Aiso et al. titled "Compared with the intake of commercial vegetable juice, the intake of fresh fruit and komatsuna (Brassica rapa L. var perviridis) juice mixture reduces serum cholesterol in middle-aged men: a randomized controlled pilot study" does not meet the expected standards of Lipids in Health and Disease. Although the article concludes that there are some significant benefits to their komatsuna juice mixture, these claims are not supported by the statistical analyses used. An incorrect procedure was used to compare the differences in two treatment groups over time, and a large number of outcomes were tested without correction; both issues are known to produce high rates of false positives, making the conclusions of the study unjustified. The study also fails to follow published journal standards regarding clinical trial registration and reporting. PMID:27083538

  6. Normal Range of Thoracic Kyphosis in Male School Children

    PubMed Central

    Shamsi, MohammadBagher; Veisi, Korosh; Karimi, Loghman; Sarrafzadeh, Javad; Najafi, Farid

    2014-01-01

    Background. Although there are frequent studies about normal range of thoracic kyphosis, there is still a controversy about the exact values of this curve. In nine reported studies on 10 to 20 years of age boys, the value ranged from 25.1° to 53.3°. Objective for the Study. The aim of the present research was investigation of normal ranges of thoracic kyphosis in school children in Kermanshah, western Iran. Methods. 582 male students aged 13 to 18 years old using cluster random sampling were recruited from schools in Kermanshah city, 97 students for each age. Thoracic curves were measured using the flexicurve method. Results. Mean thoracic kyphosis for whole population was 35.49° SD 7.83 and plus or minus two standard deviations ranged from 19.83° to 51.15°. It increased gradually from 13 to 16 and then there was a little decrease to 18 years. Mean values for each age (13–16) were 13 (34.41 SD 7.47°), 14 (34.86 SD 8.29°), 15 (35.79 SD 7.93°), 16 (36.49 SD 7.85°), 17 (35.84 SD 8.33°), and 18 (35.55 SD 7.07°). Conclusions. Our results are in agreement with previous reports and can be used as normal values for local and regional purposes. PMID:24967122

  7. Understanding aging.

    PubMed

    Strehler, B L

    2000-01-01

    Enormous advances in our understanding of human aging have occurred during the last 50 yr. From the late 19th to the mid-20th centuries only four comprehensive and important sources of information were available: 1. August Weismann's book entitled Essays on Heredity and Kindred Biological Problems (the first of these essays dealt with The Duration of Life; 1). Weissmann states (p. 10) "In the first place in regulating the length of life, the advantage to the species, and not to the individual, is alone of any importance. This must be obvious to any one who has once thoroughly thought out the process of natural selection_". 2. A highly systematized second early source of information on aging was the collection of essays edited by Cowdry and published in 1938. This 900+ page volume contains 34 chapters and was appropriately called Problems of Aging. 3. At about the same time Raymond Pearl published his book on aging (2). Pearl believed that aging was the indirect result of cell specialization and that only the germ line was resistant to aging. Unfortunately Pearl died in the late 1930s and is largely remembered now for having been the founding editor of Quarterly Review of Biology while he was at the Johns Hopkins University, this author's alma mater. 4. Alexis Carrel wrote a monumental scientific and philosophical book, Man, the Unknown (3). Carrel believed that he had demonstrated that vertebrate cells could be kept in culture and live indefinitely, a conclusion challenged by others (more on this later). PMID:22351262

  8. Galactic Globular Cluster Relative Ages

    NASA Astrophysics Data System (ADS)

    De Angeli, Francesca; Piotto, Giampaolo; Cassisi, Santi; Busso, Giorgia; Recio-Blanco, Alejandra; Salaris, Maurizio; Aparicio, Antonio; Rosenberg, Alfred

    2005-07-01

    We present accurate relative ages for a sample of 55 Galactic globular clusters. The ages have been obtained by measuring the difference between the horizontal branch and the turnoff in two internally photometrically homogeneous databases. The mutual consistency of the two data sets has been assessed by comparing the ages of 16 globular clusters in common between the two databases. We have also investigated the consistency of our relative age determination within the recent stellar model framework. All clusters with [Fe/H]<-1.7 are found to be old and coeval, with the possible exception of two objects, which are marginally younger. The age dispersion for the metal-poor clusters is 0.6 Gyr (rms), consistent with a null age dispersion. Intermediate-metallicity clusters (-1.7<[Fe/H]<-0.8) are on average 1.5 Gyr younger than the metal-poor ones, with an age dispersion of 1.0 Gyr (rms) and a total age range of ~3 Gyr. About 15% of the intermediate-metallicity clusters are coeval with the oldest clusters. All the clusters with [Fe/H]>-0.8 are ~1 Gyr younger than the most metal-poor ones, with a relatively small age dispersion, although the metal-rich sample is still too small to allow firmer conclusions. There is no correlation of the cluster age with the galactocentric distance. We briefly discuss the implication of these observational results for the formation history of the Galaxy. Based on observations with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555, and on observations made at the European Southern Observatory, La Silla, Chile, and with the Isaac Newton Group Telescopes.

  9. School age child development (image)

    MedlinePlus

    School age child development is a range from 6 to 12 years of age. During this time period observable differences in height, ... peers. As always, safety is important in school age children and proper safety rules should be enforced ...

  10. [Osteoporosis--prevention, diagnosis and treatment. A systematic literature review. SBU conclusions and summary].

    PubMed

    2003-11-01

    A report by the Swedish Council on Technology Assessment in Health Care (SBU) has reviewed, classified, and graded the scientific literature on prevention, diagnosis and treatment of osteoporosis. This article summarizes the overall conclusions. There is no scientific evidence to support the use of bone density measurement as a screening method in healthy, middle-aged individuals. Patients with osteoporosis-related fractures are an undertreated group as regards pharmacotherapy and other interventions to prevent new fractures. There are some evidence that physical exercise to reduce falls among elderly and hip protectors can prevent fractures. The combination therapy of calcium and vitamin D is shown to reduce the risk for hip fractures and other fractures except vertebral fractures in elderly women. Bisphosphonates are shown to reduce the number of fractures, mainly vertebral fractures. SERM is shown to reduce the risk for vertebral fractures in postmenopausal women with osteoporosis. Important risk factors for osteoporosis-related fractures that can be treated are physical inactivity, low weight, tobacco smoking, high alcohol consumption, tendency to fall, impaired vision, low exposure to sunlight, and use of corticosteroids. No particular diagnostic method or measurement site is optimal for determining the risk for fracture in all parts of the skeleton. The various measurement methods--dual energy x-ray absorbtiometry (DXA), ultrasound (QUS), and computed tomography (QCT)--are not directly comparable.

  11. Gestational age

    MedlinePlus

    Fetal age - gestational age; Gestation; Neonatal gestational age; Newborn gestational age ... Gestational age can be determined before or after birth. Before birth, your health care provider will use ultrasound to ...

  12. Laser Ranging Experiment on Lunar Reconnaissance Orbiter: Clocks and Ranges

    NASA Astrophysics Data System (ADS)

    Mao, D.; Rowlands, D. D.; McGarry, J.; Zuber, M. T.; Smith, D. E.; Torrence, M. H.; Neumann, G. A.; Mazarico, E.; Sun, X.; Zagwodzki, T. W.; Cavanaugh, J. F.; Ramos-Izquierdo, L.

    2010-12-01

    Accurate ranges from Earth to the Lunar Reconnaissance Orbiter (LRO) spacecraft Laser Ranging (LR) system supplement the precision orbit determination (POD) of LRO. LRO is tracked by ten LR stations from the International Laser Ranging Service (ILRS), using H-maser, GPS steered Rb, and Cs standard oscillators as reference clocks. The LR system routinely makes one-way range measurements via laser time-of-flight from Earth to LRO. Uplink photons are received by a telescope mounted on the high-gain antenna on LRO , transferred through a fiber optic cable to the Lunar Orbiter Laser Altimeter (LOLA), and timed-tagged by the spacecraft clock. The range from the LR Earth station to LRO is derived from paired outgoing and received times. Accurate ranges can only be obtained after solving for both the spacecraft and ground station clock errors. The drift rate and aging rate of the LRO clock are calculated from data provided by the primary LR station, NASA's Next Generation Satellite Laser Ranging System (NGSLR) in Greenbelt, Maryland. The results confirm the LRO clock oscillator mid to long term stability measured during ground testing. These rates also agree well with those determined through POD. Simultaneous and near-simultaneous ranging to LRO from multiple LR stations in America, Europe, and Australia has been successfully achieved within a 10 hour window. Data analysis of these ranging experiments allows for precision modeling of the clock behaviors of each LR ground station and characterization of the station ground fire times.

  13. 39 CFR 953.11 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Proposed findings of fact and conclusions of law... PROCEEDINGS RELATIVE TO MAILABILITY § 953.11 Proposed findings of fact and conclusions of law. Proposed findings of fact and conclusions of law shall be submitted orally or in writing at the conclusion of...

  14. 39 CFR 953.11 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Proposed findings of fact and conclusions of law... PROCEEDINGS RELATIVE TO MAILABILITY § 953.11 Proposed findings of fact and conclusions of law. Proposed findings of fact and conclusions of law shall be submitted orally or in writing at the conclusion of...

  15. Characteristic Age and True Age of Pulsars

    NASA Astrophysics Data System (ADS)

    Jiang, Long; Zhang, Cheng-Min; Tanni, Ali; Zhao, Hai-Hui

    2013-01-01

    Age of a pulsar is a useful parameter, but it is difficult to get the age from observation. We can only derive the characteristic age from the observed parameters: spin period (P) and period derivative (Ṗ). In this paper, we discussed the relationship between characteristic age and magnetic field of a pulsar. Monte Carlo simulation is also used to support the idea: it is useless to study the magnetic field evolution using characteristic age. From some observation evidences we get that: the characteristic age cannot be used as true age, especially for millisecond pulsar (MSP). The difference between them is also discussed. From the studying of breaking index and MSP's initial spin period (P0), we get the conclusion that: the problem cannot be resolved using different radiation models.

  16. Pressure Measurement Techniques for Abdominal Hypertension: Conclusions from an Experimental Model.

    PubMed

    Chopra, Sascha Santosh; Wolf, Stefan; Rohde, Veit; Freimann, Florian Baptist

    2015-01-01

    Introduction. Intra-abdominal pressure (IAP) measurement is an indispensable tool for the diagnosis of abdominal hypertension. Different techniques have been described in the literature and applied in the clinical setting. Methods. A porcine model was created to simulate an abdominal compartment syndrome ranging from baseline IAP to 30 mmHg. Three different measurement techniques were applied, comprising telemetric piezoresistive probes at two different sites (epigastric and pelvic) for direct pressure measurement and intragastric and intravesical probes for indirect measurement. Results. The mean difference between the invasive IAP measurements using telemetric pressure probes and the IVP measurements was -0.58 mmHg. The bias between the invasive IAP measurements and the IGP measurements was 3.8 mmHg. Compared to the realistic results of the intraperitoneal and intravesical measurements, the intragastric data showed a strong tendency towards decreased values. The hydrostatic character of the IAP was eliminated at high-pressure levels. Conclusion. We conclude that intragastric pressure measurement is potentially hazardous and might lead to inaccurately low intra-abdominal pressure values. This may result in missed diagnosis of elevated abdominal pressure or even ACS. The intravesical measurements showed the most accurate values during baseline pressure and both high-pressure plateaus. PMID:26113992

  17. 18 CFR 385.912 - Proposed findings of fact, conclusions of law, and comments (Rule 912).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Proposed findings of fact, conclusions of law, and comments (Rule 912). 385.912 Section 385.912 Conservation of Power and..., conclusions of law, and comments (Rule 912). (a) Within 10 days after the conclusion of the hearing, or, if...

  18. 18 CFR 385.912 - Proposed findings of fact, conclusions of law, and comments (Rule 912).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Proposed findings of fact, conclusions of law, and comments (Rule 912). 385.912 Section 385.912 Conservation of Power and..., conclusions of law, and comments (Rule 912). (a) Within 10 days after the conclusion of the hearing, or, if...

  19. 18 CFR 385.912 - Proposed findings of fact, conclusions of law, and comments (Rule 912).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Proposed findings of fact, conclusions of law, and comments (Rule 912). 385.912 Section 385.912 Conservation of Power and..., conclusions of law, and comments (Rule 912). (a) Within 10 days after the conclusion of the hearing, or, if...

  20. 39 CFR 964.14 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Proposed findings of fact and conclusions of law... findings of fact and conclusions of law. (a) Each party to a proceeding, except one who fails to answer the..., submit proposed findings of fact, conclusions of law, orders and supporting reasons either in oral...

  1. 30 CFR 44.31 - Proposed findings of fact, conclusions, and orders.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Proposed findings of fact, conclusions, and... MANDATORY SAFETY STANDARDS Hearings § 44.31 Proposed findings of fact, conclusions, and orders. After... each party may file proposed findings of fact, conclusions of law, and rule or order, together with...

  2. 49 CFR 386.57 - Proposed findings of fact, conclusions of law.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 5 2011-10-01 2011-10-01 false Proposed findings of fact, conclusions of law. 386... HAZARDOUS MATERIALS PROCEEDINGS General Rules and Hearings § 386.57 Proposed findings of fact, conclusions... proposed findings of fact, conclusions of law, and supportng reasons therefor. If the administrative...

  3. 49 CFR 386.57 - Proposed findings of fact, conclusions of law.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Proposed findings of fact, conclusions of law. 386... HAZARDOUS MATERIALS PROCEEDINGS General Rules and Hearings § 386.57 Proposed findings of fact, conclusions... proposed findings of fact, conclusions of law, and supportng reasons therefor. If the administrative...

  4. 10 CFR 2.1209 - Findings of fact and conclusions of law.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Findings of fact and conclusions of law. 2.1209 Section 2... ISSUANCE OF ORDERS Informal Hearing Procedures for NRC Adjudications § 2.1209 Findings of fact and conclusions of law. Each party shall file written post-hearing proposed findings of fact and conclusions...

  5. 43 CFR 4.842 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Proposed findings of fact and conclusions... Posthearing Procedures § 4.842 Proposed findings of fact and conclusions of law. Within 30 days after the... of fact and conclusions of law together with supporting briefs. Such proposals and briefs shall...

  6. 43 CFR 4.842 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Proposed findings of fact and conclusions... Posthearing Procedures § 4.842 Proposed findings of fact and conclusions of law. Within 30 days after the... of fact and conclusions of law together with supporting briefs. Such proposals and briefs shall...

  7. 30 CFR 44.31 - Proposed findings of fact, conclusions, and orders.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Proposed findings of fact, conclusions, and... MANDATORY SAFETY STANDARDS Hearings § 44.31 Proposed findings of fact, conclusions, and orders. After... each party may file proposed findings of fact, conclusions of law, and rule or order, together with...

  8. 10 CFR 2.1209 - Findings of fact and conclusions of law.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Findings of fact and conclusions of law. 2.1209 Section 2... ISSUANCE OF ORDERS Informal Hearing Procedures for NRC Adjudications § 2.1209 Findings of fact and conclusions of law. Each party shall file written post-hearing proposed findings of fact and conclusions...

  9. 18 CFR 385.912 - Proposed findings of fact, conclusions of law, and comments (Rule 912).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Proposed findings of fact, conclusions of law, and comments (Rule 912). 385.912 Section 385.912 Conservation of Power and..., conclusions of law, and comments (Rule 912). (a) Within 10 days after the conclusion of the hearing, or, if...

  10. 18 CFR 385.912 - Proposed findings of fact, conclusions of law, and comments (Rule 912).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Proposed findings of fact, conclusions of law, and comments (Rule 912). 385.912 Section 385.912 Conservation of Power and..., conclusions of law, and comments (Rule 912). (a) Within 10 days after the conclusion of the hearing, or, if...

  11. Overturning conclusions of Lévy flight movement patterns by fishing boats and foraging animals.

    PubMed

    Edwards, Andrew M

    2011-06-01

    A surprisingly diverse variety of foragers have previously been concluded to exhibit movement patterns known as Lévy flights, a special type of random walk. These foragers range in size from microzooplankton in experiments to fishermen in the Pacific Ocean and the North Sea. The Lévy flight conclusion implies that all the foragers have similar scale-free movement patterns that can be described by a single dimensionless parameter, the exponent micro of a power-law (Pareto) distribution. However, the previous conclusions have been made using methods that have since been shown to be problematic: inaccurate techniques were used to estimate micro, and the power-law distribution was usually assumed to hold without testing any alternative hypotheses. Therefore, I address the open question of whether the previous data still support the Lévy flight hypothesis, and thus determine whether Lévy flights really are so ubiquitous in ecology. I present a comprehensive reanalysis of 17 data sets from seven previous studies for which Lévy flight behavior had been concluded, covering marine, terrestrial, and experimental systems from four continents. I use the modern likelihood and Akaike weights approach to test whether simple alternative models are more supported by the data than Lévy flights. The previously estimated values of the power-law exponent micro do not match those calculated here using the accurate likelihood approach, and almost all of them lie outside of the likelihood-based 95% confidence intervals. Furthermore, the original power-law Lévy flight model is overwhelmingly rejected for 16 out of the 17 data sets when tested against three other simple models. For one data set, the data are consistent with coming from a bounded power-law distribution (a truncated Lévy flight). For three other data sets, an exponential distribution corresponding to a simple Poisson process is suitable. Thus, Lévy flight movement patterns are not the common phenomena that was once

  12. Overturning conclusions of Lévy flight movement patterns by fishing boats and foraging animals.

    PubMed

    Edwards, Andrew M

    2011-06-01

    A surprisingly diverse variety of foragers have previously been concluded to exhibit movement patterns known as Lévy flights, a special type of random walk. These foragers range in size from microzooplankton in experiments to fishermen in the Pacific Ocean and the North Sea. The Lévy flight conclusion implies that all the foragers have similar scale-free movement patterns that can be described by a single dimensionless parameter, the exponent micro of a power-law (Pareto) distribution. However, the previous conclusions have been made using methods that have since been shown to be problematic: inaccurate techniques were used to estimate micro, and the power-law distribution was usually assumed to hold without testing any alternative hypotheses. Therefore, I address the open question of whether the previous data still support the Lévy flight hypothesis, and thus determine whether Lévy flights really are so ubiquitous in ecology. I present a comprehensive reanalysis of 17 data sets from seven previous studies for which Lévy flight behavior had been concluded, covering marine, terrestrial, and experimental systems from four continents. I use the modern likelihood and Akaike weights approach to test whether simple alternative models are more supported by the data than Lévy flights. The previously estimated values of the power-law exponent micro do not match those calculated here using the accurate likelihood approach, and almost all of them lie outside of the likelihood-based 95% confidence intervals. Furthermore, the original power-law Lévy flight model is overwhelmingly rejected for 16 out of the 17 data sets when tested against three other simple models. For one data set, the data are consistent with coming from a bounded power-law distribution (a truncated Lévy flight). For three other data sets, an exponential distribution corresponding to a simple Poisson process is suitable. Thus, Lévy flight movement patterns are not the common phenomena that was once

  13. Stop Aging Disease! ICAD 2014

    PubMed Central

    Ilia, Stambler

    2015-01-01

    On November 1–2, 2014, there took place in Beijing, China, the first International Conference on Aging and Disease (ICAD 2014) of the International Society on Aging and Disease (ISOAD). The conference participants presented a wide and exciting front of work dedicated to amelioration of aging-related conditions, ranging from regenerative medicine through developing geroprotective substances, elucidating a wide range of mechanisms of aging and aging-related diseases, from energy metabolism through genetics and immunomodulation to systems biology. The conference further emphasized the need to intensify and support research on aging and aging-related diseases to provide solutions for the urgent health challenges of the aging society. PMID:25821637

  14. New 40Ar/39Ar age determinations and paleomagnetic results bearing on the tectonic and magmatic history of the northern Madison Range and Madison Valley region, southwestern Montana, U.S.A

    USGS Publications Warehouse

    Kellogg, K.S.; Harlan, S.S.

    2007-01-01

    Detailed 40Ar/39Ar dating and paleomagnetic analysis of dacite porphyry sills and dikes that intrude Cretaceous sedimentary rocks in the northern Madison Range in southwestern Montana show that Laramide shortening was essentially complete by ???69 Ma. A negative paleomagnetic fold test indicates that Laramide folding occurred before cooling of the dacite sills and dikes at ???69 Ma. Laramide deformation began synchronous with deposition of the Livingston Formation rocks at ???79 Ma. These results are consistent with previous observations in the region that show the onset of Laramide deformation in the northern Rocky Mountains becoming progressively younger toward the east. 40Ar/39Ar dating of additional igneous rocks in the northern Madison Valley and around Norris, Montana better define post-Laramide tectonomagmatic events in the region, including Eocene-Oligocene volcanism and Basin and Range crustal extension. Dates from three rhyolitic intrusions near Red Mountain are between 48.71 ?? 0.18 Ma and 49.42 ?? 0.18 Ma, similar to the dates from basal silicic flows of the Virginia City volcanic field (part of the southwest Montana volcanic province), suggesting that the Red Mountain intrusions may have been the sources for some of the early extrusive rocks. Magmatism in the Virginia City volcanic field became generally more mafic with time, and a ???30-Ma basalt flow near Norris is considered a late, outlying member of the volcanic field. A tuff along the east side of the Madison Valley half graben yielded a early middle Miocene date (16.2 ?? 0.19 Ma), suggesting that accelerated crustal extension and associated rapid basin sedimentation probably began in the early Miocene, slightly earlier than previous estimates.

  15. Telemetry Ranging: Concepts

    NASA Astrophysics Data System (ADS)

    Hamkins, J.; Kinman, P.; Xie, H.; Vilnrotter, V.; Dolinar, S.

    2015-11-01

    Telemetry ranging is a proposed alternative to conventional two-way ranging for determining the two-way time delay between a Deep Space Station (DSS) and a spacecraft. The advantage of telemetry ranging is that the ranging signal on the uplink is not echoed to the downlink, so that telemetry alone modulates the downlink carrier. The timing information needed on the downlink, in order to determine the two-way time delay, is obtained from telemetry frames. This article describes the phase and timing estimates required for telemetry ranging, and how two-way range is calculated from these estimates. It explains why the telemetry ranging architecture does not require the spacecraft transponder to have a high-frequency or high-quality oscillator, and it describes how a telemetry ranging system can be infused in the Deep Space Network.

  16. Epigenetic predictor of age.

    PubMed

    Bocklandt, Sven; Lin, Wen; Sehl, Mary E; Sánchez, Francisco J; Sinsheimer, Janet S; Horvath, Steve; Vilain, Eric

    2011-01-01

    From the moment of conception, we begin to age. A decay of cellular structures, gene regulation, and DNA sequence ages cells and organisms. DNA methylation patterns change with increasing age and contribute to age related disease. Here we identify 88 sites in or near 80 genes for which the degree of cytosine methylation is significantly correlated with age in saliva of 34 male identical twin pairs between 21 and 55 years of age. Furthermore, we validated sites in the promoters of three genes and replicated our results in a general population sample of 31 males and 29 females between 18 and 70 years of age. The methylation of three sites--in the promoters of the EDARADD, TOM1L1, and NPTX2 genes--is linear with age over a range of five decades. Using just two cytosines from these loci, we built a regression model that explained 73% of the variance in age, and is able to predict the age of an individual with an average accuracy of 5.2 years. In forensic science, such a model could estimate the age of a person, based on a biological sample alone. Furthermore, a measurement of relevant sites in the genome could be a tool in routine medical screening to predict the risk of age-related diseases and to tailor interventions based on the epigenetic bio-age instead of the chronological age. PMID:21731603

  17. RADIO RANGING DEVICE

    DOEpatents

    Nieset, R.T.

    1961-05-16

    A radio ranging device is described. It utilizes a super regenerative detector-oscillator in which echoes of transmitted pulses are received in proper phase to reduce noise energy at a selected range and also at multiples of the selected range.

  18. SAR ambiguous range suppression.

    SciTech Connect

    Doerry, Armin Walter

    2006-09-01

    Pulsed Radar systems suffer range ambiguities, that is, echoes from pulses transmitted at different times arrive at the receiver simultaneously. Conventional mitigation techniques are not always adequate. However, pulse modulation schemes exist that allow separation of ambiguous ranges in Doppler space, allowing easy filtering of problematic ambiguous ranges.

  19. 37 CFR 351.14 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Proposed findings of fact and conclusions of law. 351.14 Section 351.14 Patents, Trademarks, and Copyrights COPYRIGHT ROYALTY BOARD, LIBRARY OF CONGRESS COPYRIGHT ROYALTY JUDGES RULES AND PROCEDURES PROCEEDINGS § 351.14 Proposed findings of fact and conclusions of law. (a)...

  20. 40 CFR 78.17 - Proposed findings and conclusions and supporting brief.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 17 2013-07-01 2013-07-01 false Proposed findings and conclusions and supporting brief. 78.17 Section 78.17 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPEAL PROCEDURES § 78.17 Proposed findings and conclusions and...

  1. 40 CFR 78.17 - Proposed findings and conclusions and supporting brief.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Proposed findings and conclusions and supporting brief. 78.17 Section 78.17 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPEAL PROCEDURES § 78.17 Proposed findings and conclusions and...

  2. 47 CFR 1.264 - Contents of findings of fact and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Contents of findings of fact and conclusions. 1... Hearing Proceedings Hearing and Intermediate Decision § 1.264 Contents of findings of fact and conclusions. Proposed findings of fact shall be set forth in serially numbered paragraphs and shall set out in...

  3. 37 CFR 351.14 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false Proposed findings of fact and... fact and conclusions of law. (a) Any party to the proceeding may file proposed findings of fact and... determination unless the provision conflicts with a proposed finding of fact or conclusion of law filed by...

  4. 43 CFR 4.1126 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Proposed findings of fact and conclusions... Appeals Evidentiary Hearings § 4.1126 Proposed findings of fact and conclusions of law. The administrative law judge shall allow the parties to a proceeding an opportunity to submit proposed findings of...

  5. 43 CFR 4.1126 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Proposed findings of fact and conclusions... Appeals Evidentiary Hearings § 4.1126 Proposed findings of fact and conclusions of law. The administrative law judge shall allow the parties to a proceeding an opportunity to submit proposed findings of...

  6. 21 CFR 1316.64 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Proposed findings of fact and conclusions of law... ADMINISTRATIVE FUNCTIONS, PRACTICES, AND PROCEDURES Administrative Hearings § 1316.64 Proposed findings of fact and conclusions of law. Any party in the hearing may file in quintuplicate proposed findings of...

  7. 47 CFR 1.264 - Contents of findings of fact and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Contents of findings of fact and conclusions. 1... Hearing Proceedings Hearing and Intermediate Decision § 1.264 Contents of findings of fact and conclusions. Proposed findings of fact shall be set forth in serially numbered paragraphs and shall set out in...

  8. Healthy Aging

    MedlinePlus

    ... About Us Contact Us Text size | Print | Healthy Aging This information in Spanish ( en español ) A healthy ... Aging email updates. Enter email address Submit Healthy Aging news Accessibility | Privacy policy | Disclaimers | FOIA | Link to ...

  9. Healthy Aging

    MedlinePlus

    ... A Change Contrast print sign up Share Healthy Aging This category offers tips on how to stay ... with Smell Problems with Taste Skin Care and Aging Sleep and Aging Taking Medicines Talking with Your ...

  10. Telemetry Ranging: Signal Processing

    NASA Astrophysics Data System (ADS)

    Hamkins, J.; Kinman, P.; Xie, H.; Vilnrotter, V.; Dolinar, S.

    2016-02-01

    This article describes the details of the signal processing used in a telemetry ranging system in which timing information is extracted from the downlink telemetry signal in order to compute spacecraft range. A previous article describes telemetry ranging concepts and architecture, which are a slight variation of a scheme published earlier. As in that earlier work, the telemetry ranging concept eliminates the need for a dedicated downlink ranging signal to communicate the necessary timing information. The present article describes the operation and performance of the major receiver functions on the spacecraft and the ground --- many of which are standard tracking loops already in use in JPL's flight and ground radios --- and how they can be used to provide the relevant information for making a range measurement. It also describes the implementation of these functions in software, and performance of an end-to-end software simulation of the telemetry ranging system.

  11. Dental age assessment among Tunisian children using the Demirjian method

    PubMed Central

    Aissaoui, Abir; Salem, Nidhal Haj; Mougou, Meryam; Maatouk, Fethi; Chadly, Ali

    2016-01-01

    Context: Since Demirjian system of estimating dental maturity was first described, many researchers from different countries have tested its accuracy among diverse populations. Some of these studies have pointed out a need to determine population-specific standards. Aim: The aim of this study is to evaluate the suitability of the Demirjian's method for dental age assessment in Tunisian children. Materials and Methods: This is a prospective study previously approved by the Research Ethics Local Committee of the University Hospital Fattouma Bourguiba of Monastir (Tunisia). Panoramic radiographs of 280 healthy Tunisian children of age 2.8–16.5 years were examined with Demirjian method and scored by three trained observers. Statistical Analysis Used: Dental age was compared to chronological age by using the analysis of variance (ANOVA) test. Cohen's Kappa test was performed to calculate the intra- and inter-examiner agreements. Results: Underestimation was seen in children aged between 9 and 16 years and the range of accuracy varied from −0.02 to 3 years. The advancement in dental age as determined by Demirjian system when compared to chronological age ranged from 0.3 to 1.32 year for young males and from 0.26 to 1.37 year for young females (age ranged from 3 to 8 years). Conclusions: The standards provided by Demirjian for French-Canadian children may not be suitable for Tunisian children. Each population of children may need their own specific standard for an accurate estimation of chronological age. PMID:27051223

  12. Telemetry-Based Ranging

    NASA Technical Reports Server (NTRS)

    Hamkins, Jon; Vilnrotter, Victor A.; Andrews, Kenneth S.; Shambayati, Shervin

    2011-01-01

    A telemetry-based ranging scheme was developed in which the downlink ranging signal is eliminated, and the range is computed directly from the downlink telemetry signal. This is the first Deep Space Network (DSN) ranging technology that does not require the spacecraft to transmit a separate ranging signal. By contrast, the evolutionary ranging techniques used over the years by NASA missions, including sequential ranging (transmission of a sequence of sinusoids) and PN-ranging (transmission of a pseudo-noise sequence) whether regenerative (spacecraft acquires, then regenerates and retransmits a noise-free ranging signal) or transparent (spacecraft feeds the noisy demodulated uplink ranging signal into the downlink phase modulator) relied on spacecraft power and bandwidth to transmit an explicit ranging signal. The state of the art in ranging is described in an emerging CCSDS (Consultative Committee for Space Data Systems) standard, in which a pseudo-noise (PN) sequence is transmitted from the ground to the spacecraft, acquired onboard, and the PN sequence is coherently retransmitted back to the ground, where a delay measurement is made between the uplink and downlink signals. In this work, the telemetry signal is aligned with the uplink PN code epoch. The ground station computes the delay between the uplink signal transmission and the received downlink telemetry. Such a computation is feasible because symbol synchronizability is already an integral part of the telemetry design. Under existing technology, the telemetry signal cannot be used for ranging because its arrival-time information is not coherent with any Earth reference signal. By introducing this coherence, and performing joint telemetry detection and arrival-time estimation on the ground, a high-rate telemetry signal can provide all the precision necessary for spacecraft ranging.

  13. Interpreting systematic reviews: are we ready to make our own conclusions? A cross-sectional study

    PubMed Central

    2011-01-01

    Background Independent evaluation of clinical evidence is advocated in evidence-based medicine (EBM). However, authors' conclusions are often appealing for readers who look for quick messages. We assessed how well a group of Malaysian hospital practitioners and medical students derived their own conclusions from systematic reviews (SRs) and to what extent these were influenced by their prior beliefs and the direction of the study results. Methods We conducted two cross-sectional studies: one with hospital practitioners (n = 150) attending an EBM course in June 2008 in a tertiary hospital and one with final-year medical students (n = 35) in November 2008. We showed our participants four Cochrane SR abstracts without the authors' conclusions. For each article, the participants chose a conclusion from among six options comprising different combinations of the direction of effect and the strength of the evidence. We predetermined the single option that best reflected the actual authors' conclusions and labelled this as our best conclusion. We compared the participants' choices with our predetermined best conclusions. Two chosen reviews demonstrated that the intervention was beneficial ("positive"), and two others did not ("negative"). We also asked the participants their prior beliefs about the intervention. Results Overall, 60.3% correctly identified the direction of effect, and 30.1% chose the best conclusions, having identified both the direction of effect and the strength of evidence. More students (48.2%) than practitioners (22.2%) chose the best conclusions (P < 0.001). Fewer than one-half (47%) correctly identified the direction of effect against their prior beliefs. "Positive" SRs were more likely than "negative" SRs to change the participants' beliefs about the effect of the intervention (relative risk (RR) 1.8, 95% confidence interval 1.3 to 2.6) and "convert" those who were previously unsure by making them choose the appropriate direction of effect (RR 1

  14. Forensic scientists' conclusions: how readable are they for non-scientist report-users?

    PubMed

    Howes, Loene M; Kirkbride, K Paul; Kelty, Sally F; Julian, Roberta; Kemp, Nenagh

    2013-09-10

    Scientists have an ethical responsibility to assist non-scientists to understand their findings and expert opinions before they are used as decision-aids within the criminal justice system. The communication of scientific expert opinion to non-scientist audiences (e.g., police, lawyers, and judges) through expert reports is an important but under-researched issue. Readability statistics were used to assess 111 conclusions from a proficiency test in forensic glass analysis. The conclusions were written using an average of 23 words per sentence, and approximately half of the conclusions were expressed using the active voice. At an average Flesch-Kincaid Grade level of university undergraduate (Grade 13), and Flesch Reading Ease score of difficult (42), the conclusions were written at a level suitable for people with some tertiary education in science, suggesting that the intended non-scientist readers would find them difficult to read. To further analyse the readability of conclusions, descriptive features of text were used: text structure; sentence structure; vocabulary; elaboration; and coherence and unity. Descriptive analysis supported the finding that texts were written at a level difficult for non-scientists to read. Specific aspects of conclusions that may pose difficulties for non-scientists were located. Suggestions are included to assist scientists to write conclusions with increased readability for non-scientist readers, while retaining scientific integrity. In the next stage of research, the readability of expert reports in their entirety is to be explored. PMID:23890623

  15. Forensic scientists' conclusions: how readable are they for non-scientist report-users?

    PubMed

    Howes, Loene M; Kirkbride, K Paul; Kelty, Sally F; Julian, Roberta; Kemp, Nenagh

    2013-09-10

    Scientists have an ethical responsibility to assist non-scientists to understand their findings and expert opinions before they are used as decision-aids within the criminal justice system. The communication of scientific expert opinion to non-scientist audiences (e.g., police, lawyers, and judges) through expert reports is an important but under-researched issue. Readability statistics were used to assess 111 conclusions from a proficiency test in forensic glass analysis. The conclusions were written using an average of 23 words per sentence, and approximately half of the conclusions were expressed using the active voice. At an average Flesch-Kincaid Grade level of university undergraduate (Grade 13), and Flesch Reading Ease score of difficult (42), the conclusions were written at a level suitable for people with some tertiary education in science, suggesting that the intended non-scientist readers would find them difficult to read. To further analyse the readability of conclusions, descriptive features of text were used: text structure; sentence structure; vocabulary; elaboration; and coherence and unity. Descriptive analysis supported the finding that texts were written at a level difficult for non-scientists to read. Specific aspects of conclusions that may pose difficulties for non-scientists were located. Suggestions are included to assist scientists to write conclusions with increased readability for non-scientist readers, while retaining scientific integrity. In the next stage of research, the readability of expert reports in their entirety is to be explored.

  16. Heterogeneity in Healthy Aging

    PubMed Central

    Lowsky, David J.; Olshansky, S. Jay; Bhattacharya, Jay

    2014-01-01

    For a surprisingly large segment of the older population, chronological age is not a relevant marker for understanding, measuring, or experiencing healthy aging. Using the 2003 Medical Expenditure Panel Survey and the 2004 Health and Retirement Study to examine the proportion of Americans exhibiting five markers of health and the variation in health-related quality of life across each of eight age groups, we find that a significant proportion of older Americans is healthy within every age group beginning at age 51, including among those aged 85+. For example, 48% of those aged 51–54 and 28% of those aged 85+ have excellent or very good self-reported health status; similarly, 89% of those aged 51–54 and 56% of those aged 85+ report no health-based limitations in work or housework. Also, health-related quality of life ranges widely within every age group, yet there is only a comparatively small variation in median quality of life across age groups, suggesting that older Americans today may be experiencing substantially different age-health trajectories than their predecessors. Patterns are similar for medical expenditures. Several policy implications are explored. PMID:24249734

  17. "Aging bull'.

    PubMed

    Geelhoed, G W

    1996-12-01

    An old bull, it is said by those who know, can have his troubles. Included among these are vertebral osteosclerosis and ankylosing spondylosis; this stiffening up limits, rather than accentuates, the value and reproductive potential of a stud bull past his prime. Associated with these abnormalities, however-and not seen in age-matched cows of comparable breeds-are fascinating endocrine neoplasms suggestive of a pattern that could be productive as a model of human hereditary endocrine abnormalities. Adjacent to the thyroid gland in other vertebrates are ultimobranchial bodies that are incorporated into the lateral thyroid lobes in primates as the parafollicular "C cells' of the thyroid. These are the cells in man that give rise to medullary thyroid cancer and are associated with calcitonin secretion, useful as a tumor marker. In aging bulls of whatever breed, nearly half exhibit abnormality of these ultimobranchial bodies: 20% show hyperplasia, and 30% have frank neoplasia. These ultimobranchial tumors appear in bulls passing 6 1/2 years in age, and are absent in young bulls and all cows of any age. Calcitonin can be demonstrated in the ultimobranchial tumors from bulls, and secretion is stimulated by calcium infusion, though serum calcium remains normal. The ultimobranchial tumors themselves can range from hyperplasia through adenoma to metastasizing carcinoma-in fact, representing one of the commoner cattle cancers. Parathyroid glands taken from bulls with these ultimobranchial tumors initially show evidence of inhibited secretory activity and morphologic atrophy, but later go on to develop hyperplasia and, eventually, autonomy. Cattle forage on calcium-rich diets. Bulls appear to respond to this calcium excess from the positive balance, but breeding cows have the unique calcium deficits of the high net loss of calcium through lactation and the large requirements of calcifying a fetal skeleton. Chronic stimulation of the APUD-derived ultimobranchial bodies by high

  18. [The reliable and plausible conclusions in the decisions of the forensic medical experts].

    PubMed

    Kovalev, A V; Shmarov, L A; Ten'kov, A A

    2016-01-01

    The authors characterize in brief the conclusions drawn by the forensic medical experts in the course of their professional activities with special reference to their reliability and plausibility. The most common errors creeping into the conclusions are discussed together with the approaches to their prevention and/or correction. This article continues a series of publications of the same authors concerning the main logical errors encountered in the conclusions of the forensic medical experts. The results of a deeper analysis of such errors will be published elsewhere. PMID:27030098

  19. Micron Accurate Absolute Ranging System: Range Extension

    NASA Technical Reports Server (NTRS)

    Smalley, Larry L.; Smith, Kely L.

    1999-01-01

    The purpose of this research is to investigate Fresnel diffraction as a means of obtaining absolute distance measurements with micron or greater accuracy. It is believed that such a system would prove useful to the Next Generation Space Telescope (NGST) as a non-intrusive, non-contact measuring system for use with secondary concentrator station-keeping systems. The present research attempts to validate past experiments and develop ways to apply the phenomena of Fresnel diffraction to micron accurate measurement. This report discusses past research on the phenomena, and the basis of the use Fresnel diffraction distance metrology. The apparatus used in the recent investigations, experimental procedures used, preliminary results are discussed in detail. Continued research and equipment requirements on the extension of the effective range of the Fresnel diffraction systems is also described.

  20. FIELD EVALUATION OF THE IN-SITU TREATMENTS TO REDUCE SOIL LEAD BIOAVAILABILITY: CONCLUSIONS

    EPA Science Inventory

    This presentation summarizes the conclusion of the technical issues associated with the Pb bioavailability experiment which IINERT has been conducting and further to illustrate that although bioavailability is a simple concept, its measurement and the implementation of the measur...

  1. 31 CFR 501.735 - Proposed findings, conclusions and supporting briefs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Judge, each party shall have an opportunity, reasonable in light of all the circumstances, to file in... counter statement of proposed findings and conclusions shall, in addition to any other matter...

  2. 31 CFR 501.735 - Proposed findings, conclusions and supporting briefs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Judge, each party shall have an opportunity, reasonable in light of all the circumstances, to file in... counter statement of proposed findings and conclusions shall, in addition to any other matter...

  3. Application of Artificial Neural Networks in the Heart Electrical Axis Position Conclusion Modeling

    NASA Astrophysics Data System (ADS)

    Bakanovskaya, L. N.

    2016-08-01

    The article touches upon building of a heart electrical axis position conclusion model using an artificial neural network. The input signals of the neural network are the values of deflections Q, R and S; and the output signal is the value of the heart electrical axis position. Training of the network is carried out by the error propagation method. The test results allow concluding that the created neural network makes a conclusion with a high degree of accuracy.

  4. Automatic range selector

    DOEpatents

    McNeilly, Clyde E.

    1977-01-04

    A device is provided for automatically selecting from a plurality of ranges of a scale of values to which a meter may be made responsive, that range which encompasses the value of an unknown parameter. A meter relay indicates whether the unknown is of greater or lesser value than the range to which the meter is then responsive. The rotatable part of a stepping relay is rotated in one direction or the other in response to the indication from the meter relay. Various positions of the rotatable part are associated with particular scales. Switching means are sensitive to the position of the rotatable part to couple the associated range to the meter.

  5. Range Scheduling Aid (RSA)

    NASA Technical Reports Server (NTRS)

    Logan, J. R.; Pulvermacher, M. K.

    1991-01-01

    Range Scheduling Aid (RSA) is presented in the form of the viewgraphs. The following subject areas are covered: satellite control network; current and new approaches to range scheduling; MITRE tasking; RSA features; RSA display; constraint based analytic capability; RSA architecture; and RSA benefits.

  6. Knowledge, attitude and practice of the smear test and its relation with female age 1

    PubMed Central

    Silveira, Nara Sibério Pinho; Vasconcelos, Camila Teixeira Moreira; Nicolau, Ana Izabel Oliveira; Oriá, Mônica Oliveira Batista; Pinheiro, Patricia Neyva da Costa; Pinheiro, Ana Karina Bezerra

    2016-01-01

    Abstract Objective: to verify the association among the knowledge attitude and practice of women in relation to the smear test and the age range. Method: a cross-sectional research was undertaken, associated with the knowledge, attitude and practice survey at a Primary Health Care service. The sample consisted of 775 women, distributed in three age ranges: adolescent, young and elderly. Results: although high rates of inappropriate knowledge were found in all age ranges, it was significantly higher among the adolescents (p=0.000). A similar trend was found in the attitude component, with percentages of inappropriateness in adolescence that drop as age advances (p=0.000). Nevertheless, no statistical difference among the groups was found in terms of practice (p=0.852). Conclusion: the study demonstrated a relation between the age range and knowledge, attitude and practice of the smear test. PMID:27305183

  7. A fallacious jar? The peculiar relation between descriptive premises and normative conclusions in neuroethics.

    PubMed

    Wagner, Nils-Frederic; Northoff, Georg

    2015-06-01

    Ethical questions have traditionally been approached through conceptual analysis. Inspired by the rapid advance of modern brain imaging techniques, however, some ethical questions appear in a new light. For example, hotly debated trolley dilemmas have recently been studied by psychologists and neuroscientists alike, arguing that their findings can support or debunk moral intuitions that underlie those dilemmas. Resulting from the wedding of philosophy and neuroscience, neuroethics has emerged as a novel interdisciplinary field that aims at drawing conclusive relationships between neuroscientific observations and normative ethics. A major goal of neuroethics is to derive normative ethical conclusions from the investigation of neural and psychological mechanisms underlying ethical theories, as well as moral judgments and intuitions. The focus of this article is to shed light on the structure and functioning of neuroethical arguments of this sort, and to reveal particular methodological challenges that lie concealed therein. We discuss the methodological problem of how one can--or, as the case may be, cannot--validly infer normative conclusions from neuroscientific observations. Moreover, we raise the issue of how preexisting normative ethical convictions threaten to invalidate the interpretation of neuroscientific data, and thus arrive at question-begging conclusions. Nonetheless, this is not to deny that current neuroethics rightly presumes that moral considerations about actual human lives demand empirically substantiated answers. Therefore, in conclusion, we offer some preliminary reflections on how the discussed methodological challenges can be met.

  8. Jumping to conclusions and delusions: the impact of discussion of the bias on the bias.

    PubMed

    Warman, Debbie M; Martin, Joel M; Lysaker, Paul

    2013-11-01

    The present study was an investigation of the impact a brief intervention designed to raise awareness of a cognitive bias known to be robust for individuals with delusions has on the reasoning strategies of individuals with delusions. Individuals with delusions (n=57) were randomly assigned either to receive or not to receive a discussion of the jumping to conclusions bias and its pitfalls. Participants' performance on 3 reasoning trials - 1 emotionally neutral (beads) and 2 emotionally salient (self-referred survey words) - was then assessed; the number of stimuli participants requested before making a decision was evaluated to determine if the Jumping to Conclusions Discussion resulted in increased data gathering. There was no difference between groups (those who received and those who did not receive the Jumping to Conclusions Discussion) in terms of how many beads they gathered (p=.36), but there were significant differences on both reasoning trials of emotionally salient stimuli (p's<.05), such that participants who received the Jumping to Conclusions Discussion requested more stimuli on those tasks than individuals who did not receive the discussion. Thus, results suggest that discussion of the jumping to conclusions bias may impact the bias directly, at least for material that is emotional in nature. Results are discussed in terms of their relevance to cognitive behavioral therapies for psychosis and existing research on reasoning and delusions.

  9. Conclusiveness of fine needle aspiration in 2419 histologically confirmed benign and malignant breast lesions.

    PubMed

    Kooistra, B; Wauters, C; Wobbes, T; Strobbe, L

    2011-06-01

    We aimed to retrospectively assess (1) the conclusiveness of breast fine needle aspiration (FNA) in a histologically confirmed population and (2) the clinical and radiologic determinants of a conclusive diagnosis. Aspirates were diagnosed as inadequate, benign, atypical, suspicious or malignant. We defined a conclusive FNA diagnosis as 'benign' in histologically benign lesions and as 'malignant' in histologically malignant lesions. In 2419 breast lesions, the proportion of conclusive diagnoses was 46.1% (95% confidence interval, 42.0-50.2%) in histologically benign lesions (n = 571) and 81.6% (95% confidence interval, 79.8%-83.4%) in histologically malignant lesions (n = 1848). On multivariate analysis, factors associated with a conclusive preoperative diagnosis included tumour diameter of 2-2.9 cm (P < 0.001), malignant histology (P < 0.001) and the pathologist examining the aspirate (P = 0.02). Breast FNA has to be utilised selectively in the routine work-up of breast lesions. In suspicious lesions of large size, FNA may still be used to obtain a quick confirmation of malignancy.

  10. Conclusions: Overview of Findings from the ERA Study, Inferences, and Research Implications

    ERIC Educational Resources Information Center

    Rutter, Michael; Sonuga-Barke, Edmund J.

    2010-01-01

    In this monograph, the authors have brought the findings of the English and Romanian Adoptee (ERA) study up to age 15 years and, in so doing, have focused especially on the question of whether there are deprivation-specific psychological patterns (DSPs) that differ meaningfully from other forms of psychopathology. For this purpose, their main…

  11. Executive summary and conclusions from the European Hydration Institute Expert Conference on human hydration, health, and performance.

    PubMed

    Benton, D; Braun, H; Cobo, J C; Edmonds, C; Elmadfa, I; El-Sharkawy, A; Feehally, J; Gellert, R; Holdsworth, J; Kapsokefalou, M; Kenney, W L; Leiper, J B; Macdonald, I A; Maffeis, C; Maughan, R J; Shirreffs, S M; Toth-Heyn, P; Watson, P

    2015-09-01

    On April 7-8, 2014, the European Hydration Institute hosted a small group of experts at Castle Combe Manor House, United Kingdom, to discuss a range of issues related to human hydration, health, and performance. The meeting included 18 recognized experts who brought a wealth of experience and knowledge to the topics under review. Eight selected topics were addressed, with the key issues being briefly presented before an in-depth discussion. Presented here is the executive summary and conclusions from this meeting.

  12. The grand leap of the whale up the Niagara Falls: converting philosophical conclusions into policy prescriptions.

    PubMed

    Holm, Søren

    2015-04-01

    This article analyzes a neat conjuring trick employed in bioethics, that is, the immediate conversion of a philosophical conclusion into a policy prescription, and compares it to the "grand leap of the whale up the Niagara Falls" mentioned by Benjamin Franklin. It is shown that there is no simple and easy way to achieve the conversion, by considering arguments falling under four headings: (1) reasonable disagreement about values and theories, (2) general jurisprudential arguments, (3) the differences between policymaking and philosophy, and (4) the messy world of implementation. The particular issue used to illustrate the difficulties in moving from philosophical conclusion to policy description is infanticide of healthy infants, but the analysis is general, and the conclusion that the immediate move to policy is illegitimate is quite general. PMID:25719355

  13. First International Seminar on Non Tsetse-Transmitted Animal Trypanosomoses: conclusions and recommendations.

    PubMed

    Touratier, L

    1993-03-01

    The author presents the conclusions and recommendations of the First International Seminar on Non Tsetse-Transmitted Animal Trypanosomoses (NTTAT) held in Annecy (France) on 14-16 October 1992, at which twenty-two countries and five international organisations were represented. Recommendations were made on the topics examined during the six seminar sessions, namely: general aspects of NTTAT epidemiology and diagnosis chemotherapy basic research the current situation of NTTAT in various countries final conclusions. This seminar enabled participants to collate the information currently available on NTTAT and to discuss the present state of research on these infections.

  14. SNOWY RANGE WILDERNESS, WYOMING.

    USGS Publications Warehouse

    Houston, Robert S.; Bigsby, Philip R.

    1984-01-01

    A mineral survey of the Snowy Range Wilderness in Wyoming was undertaken and was followed up with more detailed geologic and geochemical surveys, culminating in diamond drilling of one hole in the Snowy Range Wilderness. No mineral deposits were identified in the Snowy Range Wilderness, but inasmuch as low-grade uranium and associated gold resources were identified in rocks similar to those of the northern Snowy Range Wilderness in an area about 5 mi northeast of the wilderness boundary, the authors conclude that the northern half of the wilderness has a probable-resource potential for uranium and gold. Closely spaced drilling would be required to completely evaluate this mineral potential. The geologic terrane precludes the occurrence of fossil fuels.

  15. Mu-2 ranging

    NASA Technical Reports Server (NTRS)

    Martin, W. L.; Zygielbaum, A. I.

    1977-01-01

    The Mu-II Dual-Channel Sequential Ranging System designed as a model for future Deep Space Network ranging equipment is described. A list of design objectives is followed by a theoretical explanation of the digital demodulation techniques first employed in this machine. Hardware and software implementation are discussed, together with the details relating to the construction of the device. Two appendixes are included relating to the programming and operation of this equipment to yield the maximum scientific data.

  16. 20 CFR 410.471 - Conclusion by physician regarding miner's disability or death.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... disability or death. 410.471 Section 410.471 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Total Disability or Death Due to Pneumoconiosis § 410.471 Conclusion by physician regarding miner's disability or death....

  17. 20 CFR 410.471 - Conclusion by physician regarding miner's disability or death.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... disability or death. 410.471 Section 410.471 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Total Disability or Death Due to Pneumoconiosis § 410.471 Conclusion by physician regarding miner's disability or death....

  18. 39 CFR 963.17 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Proposed findings of fact and conclusions of law. 963.17 Section 963.17 Postal Service UNITED STATES POSTAL SERVICE PROCEDURES RULES OF PRACTICE IN PROCEEDINGS RELATIVE TO VIOLATIONS OF THE PANDERING ADVERTISEMENTS STATUTE, 39 U.S.C. 3008 § 963.17...

  19. Introduction and conclusions for a Discussion entitled Land resources: on the edge of the Malthusian precipice?

    PubMed Central

    Greenland, D. J.; Gregory, P. J.; Nye, P. H.

    1997-01-01

    Introduction and conclusions for a Discussion hosted by the Ciba Foundation and entitled Land resources: on the edge of the Malthusian precipice? Discussion held on the 4th and 5th December 1996, and organized and edited by D. J. Greenland, P. J. Gregory and P. H. Nye.

  20. Conclusions from Work Undertaken and Texts Approved by the CDDS, 1978-1986.

    ERIC Educational Resources Information Center

    Council of Europe, Strasbourg (France). Committee for the Development of Sport.

    This document sets forth conclusions and recommendations compiled chiefly from seminars organized for the Committee for the Development of Sport (CDDS) in various European countries between 1978 and 1986. Contributions to the document are presented on the following topics: (1) training teachers of physical education and sport; (2) sport at schools…

  1. 43 CFR 46.325 - Conclusion of the environmental assessment process.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... process. 46.325 Section 46.325 Public Lands: Interior Office of the Secretary of the Interior IMPLEMENTATION OF THE NATIONAL ENVIRONMENTAL POLICY ACT OF 1969 Environmental Assessments § 46.325 Conclusion of the environmental assessment process. Upon review of the environmental assessment by the...

  2. 43 CFR 46.325 - Conclusion of the environmental assessment process.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... process. 46.325 Section 46.325 Public Lands: Interior Office of the Secretary of the Interior IMPLEMENTATION OF THE NATIONAL ENVIRONMENTAL POLICY ACT OF 1969 Environmental Assessments § 46.325 Conclusion of the environmental assessment process. Upon review of the environmental assessment by the...

  3. 43 CFR 46.325 - Conclusion of the environmental assessment process.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... process. 46.325 Section 46.325 Public Lands: Interior Office of the Secretary of the Interior IMPLEMENTATION OF THE NATIONAL ENVIRONMENTAL POLICY ACT OF 1969 Environmental Assessments § 46.325 Conclusion of the environmental assessment process. Upon review of the environmental assessment by the...

  4. 43 CFR 46.325 - Conclusion of the environmental assessment process.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... process. 46.325 Section 46.325 Public Lands: Interior Office of the Secretary of the Interior IMPLEMENTATION OF THE NATIONAL ENVIRONMENTAL POLICY ACT OF 1969 Environmental Assessments § 46.325 Conclusion of the environmental assessment process. Upon review of the environmental assessment by the...

  5. 43 CFR 46.325 - Conclusion of the environmental assessment process.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... process. 46.325 Section 46.325 Public Lands: Interior Office of the Secretary of the Interior IMPLEMENTATION OF THE NATIONAL ENVIRONMENTAL POLICY ACT OF 1969 Environmental Assessments § 46.325 Conclusion of the environmental assessment process. Upon review of the environmental assessment by the...

  6. 12 CFR 508.12 - Proposed findings and conclusions and recommended decision.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Proposed findings and conclusions and recommended decision. 508.12 Section 508.12 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY REMOVALS, SUSPENSIONS, AND PROHIBITIONS WHERE A CRIME IS CHARGED OR PROVEN § 508.12...

  7. 12 CFR 108.12 - Proposed findings and conclusions and recommended decision.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Proposed findings and conclusions and recommended decision. 108.12 Section 108.12 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY REMOVALS, SUSPENSIONS, AND PROHIBITIONS WHERE A CRIME IS CHARGED OR PROVEN § 108.12...

  8. 12 CFR 108.12 - Proposed findings and conclusions and recommended decision.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Proposed findings and conclusions and recommended decision. 108.12 Section 108.12 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY REMOVALS, SUSPENSIONS, AND PROHIBITIONS WHERE A CRIME IS CHARGED OR PROVEN § 108.12...

  9. 12 CFR 508.12 - Proposed findings and conclusions and recommended decision.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 6 2014-01-01 2012-01-01 true Proposed findings and conclusions and recommended decision. 508.12 Section 508.12 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY REMOVALS, SUSPENSIONS, AND PROHIBITIONS WHERE A CRIME IS CHARGED OR PROVEN § 508.12...

  10. Adolescents with Autism Spectrum Disorder Show a Circumspect Reasoning Bias Rather than "Jumping-to-Conclusions"

    ERIC Educational Resources Information Center

    Brosnan, Mark; Chapman, Emma; Ashwin, Chris

    2014-01-01

    People with autism spectrum disorders (ASD) often take longer to make decisions. The Autism-Psychosis Model proposes that people with autism and psychosis show the opposite pattern of results on cognitive tasks. As those with psychosis show a jump-to-conclusions reasoning bias, those with ASD should show a circumspect reasoning bias.…

  11. 41 CFR 60-30.25 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 1 2011-07-01 2009-07-01 true Proposed findings of fact and conclusions of law. 60-30.25 Section 60-30.25 Public Contracts and Property Management Other... OPPORTUNITY UNDER EXECUTIVE ORDER 11246 Post-Hearing Procedures § 60-30.25 Proposed findings of fact...

  12. 41 CFR 60-30.25 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Proposed findings of fact and conclusions of law. 60-30.25 Section 60-30.25 Public Contracts and Property Management Other... OPPORTUNITY UNDER EXECUTIVE ORDER 11246 Post-Hearing Procedures § 60-30.25 Proposed findings of fact...

  13. Issues in the Conceptualisation and Measurement of Socioeconomic Background: Do Different Measures Generate Different Conclusions?

    ERIC Educational Resources Information Center

    Marks, Gary Neil

    2011-01-01

    Parental occupation and education are used extensively in the analysis of socioeconomic inequalities in education and subsequent social and economic outcomes. The purpose of this paper is to examine if different ways of measuring socioeconomic background substantially alter substantive conclusions on cross-national differences in socioeconomic…

  14. Tritium in precipitation of Vostok (Antarctica): conclusions on the tritium latitude effect.

    PubMed

    Hebert, Detlef

    2011-09-01

    During the Antarctic summer of 1985 near the Soviet Antarctic station Vostok, firn samples for tritium measurements were obtained down to a depth of 2.40 m. The results of the tritium measurements are presented and discussed. Based on this and other data, conclusions regarding the tritium latitude effect are derived.

  15. On conclusive eavesdropping and measures of mutual information in quantum key distribution

    NASA Astrophysics Data System (ADS)

    Rastegin, Alexey E.

    2016-03-01

    We address the question of quantifying eavesdropper's information gain in an individual attack on systems of quantum key distribution. It is connected with the concept of conclusive eavesdropping introduced by Brandt. Using the BB84 protocol, we examine the problem of estimating a performance of conclusive entangling probe. The question of interest depends on the choice of a quantitative measure of eavesdropper's information about the error-free sifted bits. The Fuchs-Peres-Brandt probe realizes a very powerful individual attack on the BB84 scheme. In the usual formulation, Eve utilizes the Helstrom scheme in distinguishing between the two output probe states. In conclusive eavesdropping, the unambiguous discrimination is used. Comparing these two versions allows to demonstrate serious distinctions between widely used quantifiers of mutual information. In particular, the so-called Rényi mutual information does not seem to be a completely legitimate measure of an amount of mutual information. It is brightly emphasized with the example of conclusive eavesdropping.

  16. 20 CFR 404.803 - Conclusiveness of the record of your earnings.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Conclusiveness of the record of your earnings... the record of your earnings. (a) Generally. For social security purposes, SSA records are evidence of the amounts of your earnings and the periods in which they were received. (b) Before time limit...

  17. Aging and functional brain networks

    SciTech Connect

    Tomasi D.; Tomasi, D.; Volkow, N.D.

    2011-07-11

    Aging is associated with changes in human brain anatomy and function and cognitive decline. Recent studies suggest the aging decline of major functional connectivity hubs in the 'default-mode' network (DMN). Aging effects on other networks, however, are largely unknown. We hypothesized that aging would be associated with a decline of short- and long-range functional connectivity density (FCD) hubs in the DMN. To test this hypothesis, we evaluated resting-state data sets corresponding to 913 healthy subjects from a public magnetic resonance imaging database using functional connectivity density mapping (FCDM), a voxelwise and data-driven approach, together with parallel computing. Aging was associated with pronounced long-range FCD decreases in DMN and dorsal attention network (DAN) and with increases in somatosensory and subcortical networks. Aging effects in these networks were stronger for long-range than for short-range FCD and were also detected at the level of the main functional hubs. Females had higher short- and long-range FCD in DMN and lower FCD in the somatosensory network than males, but the gender by age interaction effects were not significant for any of the networks or hubs. These findings suggest that long-range connections may be more vulnerable to aging effects than short-range connections and that, in addition to the DMN, the DAN is also sensitive to aging effects, which could underlie the deterioration of attention processes that occurs with aging.

  18. Aging assessment of reactor instrumentation and protection system components. Aging-related operating experiences

    SciTech Connect

    Gehl, A.C.; Hagen, E.W.

    1992-07-01

    A study of the aging-related operating experiences throughout a five-year period (1984--1988) of six generic instrumentation modules (indicators, sensors, controllers, transmitters, annunciators, and recorders) was performed as a part of the Nuclear Plant Aging Research Program. The effects of aging from operational and environmental stressors were characterized from results depicted in Licensee Event Reports (LERs). The data are graphically displayed as frequency of events per plant year for operating plant ages from 1 to 28 years to determine aging-related failure trend patterns. Three main conclusions were drawn from this study: (1) Instrumentation and control (I&C) modules make a modest contribution to safety-significant events: 17% of LERs issued during 1984--1988 dealt with malfunctions of the six I&C modules studied, and 28% of the LERs dealing with these I&C module malfunctions were aging related (other studies show a range 25--50%); (2) Of the six modules studied, indicators, sensors, and controllers account for the bulk (83%) of aging-related failures; and (3) Infant mortality appears to be the dominant aging-related failure mode for most I&C module categories (with the exception of annunciators and recorders, which appear to fail randomly).

  19. Skin Aging

    MedlinePlus

    ... too. Sunlight is a major cause of skin aging. You can protect yourself by staying out of ... person has smoked. Many products claim to revitalize aging skin or reduce wrinkles, but the Food and ...

  20. In Vivo Brillouin Analysis of the Aging Crystalline Lens

    PubMed Central

    Besner, Sebastien; Scarcelli, Giuliano; Pineda, Roberto; Yun, Seok-Hyun

    2016-01-01

    Purpose To analyze the age dependence of the longitudinal modulus of the crystalline lens in vivo using Brillouin scattering data in healthy subjects. Methods Brillouin scans were performed along the crystalline lens in 56 eyes from 30 healthy subjects aged from 19 to 63 years. Longitudinal elastic modulus was acquired along the sagittal axis of the lens with a transverse and axial resolution of 4 and 60 μm, respectively. The relative lens stiffness was computed, and correlations with age were analyzed. Results Brillouin axial profiles revealed nonuniform longitudinal modulus within the lens, increasing from a softer periphery toward a stiffer central plateau at all ages. The longitudinal modulus at the central plateau showed no age dependence in a range of 19 to 45 years and a slight decrease with age from 45 to 63 years. A significant intersubject variability was observed in an age-matched analysis. Importantly, the extent of the central stiff plateau region increased steadily over age from 19 to 63 years. The slope of change in Brillouin modulus in the peripheral regions were nearly age-invariant. Conclusions The adult human lens showed no measurable age-related increase in the peak longitudinal modulus. The expansion of the stiff central region of the lens is likely to be the major contributing factor to age-related lens stiffening. Brillouin microscopy may be useful in characterizing the crystalline lens for the optimization of surgical or pharmacological treatments aimed at restoring accommodative power. PMID:27699407

  1. Laser Ranging Simulation Program

    NASA Technical Reports Server (NTRS)

    Piazolla, Sabino; Hemmati, Hamid; Tratt, David

    2003-01-01

    Laser Ranging Simulation Program (LRSP) is a computer program that predicts selected aspects of the performances of a laser altimeter or other laser ranging or remote-sensing systems and is especially applicable to a laser-based system used to map terrain from a distance of several kilometers. Designed to run in a more recent version (5 or higher) of the MATLAB programming language, LRSP exploits the numerical and graphical capabilities of MATLAB. LRSP generates a graphical user interface that includes a pop-up menu that prompts the user for the input of data that determine the performance of a laser ranging system. Examples of input data include duration and energy of the laser pulse, the laser wavelength, the width of the laser beam, and several parameters that characterize the transmitting and receiving optics, the receiving electronic circuitry, and the optical properties of the atmosphere and the terrain. When the input data have been entered, LRSP computes the signal-to-noise ratio as a function of range, signal and noise currents, and ranging and pointing errors.

  2. The 1993 Finnish Interdisciplinary Seminar on SETI - A review of aims, approaches and conclusions

    NASA Astrophysics Data System (ADS)

    Seppanen, Jouko

    1993-10-01

    The communications of the International Interdisciplinary Seminar on SETI, held on March 6-7, 1993 in Vantaa, Finland, are reviewed and the contents and conclusions of papers summarized. The seminar was organized jointly by the Finnish Artificial Intelligence Society (FAIS), Finnish Astronomical Society, Ursa Astronomical Association and Heureka - The Finnish Science Centre. As the ninth in a series of intelligence-related seminars of FAIS, SETI was chosen as the topic for spring 1993, noting the new ten year NASA SETI program HRMS (High Resolution Micro-wave Survey), commenced on Columbus Day, October 12, 1992. The aims and the interdisciplinary format of the seminar are described, the main results and conclusions of papers are restated, and the seminar publications introduced. The summaries of papers are based on their abstracts and contain excerpts from texts.

  3. Counseling Gifted and Talented Students in Jordanian Inclusive Schools: Conclusion and Implication

    ERIC Educational Resources Information Center

    El-Zraigat, Ibrahim A.

    2012-01-01

    The primary purpose of this study was to review counseling services for students who are gifted and talented at Jordanian inclusive schools in relation to theoretical counseling literature. The present study is considered a theoretical study. Gifted and talented students exhibit a wide range of characteristics, among of which are intellectual…

  4. Reconfigurable laser ranging instrument

    NASA Astrophysics Data System (ADS)

    Schneiter, John

    1994-03-01

    This paper describes the design and operation of a fast, flexible, non-contact, eye-safe laser ranging instrument useful in a variety of industrial metrology situations, such as in-process machining control and part inspection. The system has variable computer-controlled standoff and depth of field, and can obtain 3-D images of surfaces within a range of from 1.5 ft to almost 10 ft from the final optical element. The minimum depth of field is about 3.5 in. at 1.5 ft and about 26 in. at the far range. The largest depth of field for which useful data are available is about 41 in. Resolution, with appropriate averaging, is about one part in 4000 of the depth of field, which implies a best case resolution for this prototype of 0.00075 in. System flexibility is achieved by computer controlled relative positioning of optical components.

  5. The range scheduling aid

    NASA Technical Reports Server (NTRS)

    Halbfinger, Eliezer M.; Smith, Barry D.

    1991-01-01

    The Air Force Space Command schedules telemetry, tracking and control activities across the Air Force Satellite Control network. The Range Scheduling Aid (RSA) is a rapid prototype combining a user-friendly, portable, graphical interface with a sophisticated object-oriented database. The RSA has been a rapid prototyping effort whose purpose is to elucidate and define suitable technology for enhancing the performance of the range schedulers. Designing a system to assist schedulers in their task and using their current techniques as well as enhancements enabled by an electronic environment, has created a continuously developing model that will serve as a standard for future range scheduling systems. The RSA system is easy to use, easily ported between platforms, fast, and provides a set of tools for the scheduler that substantially increases his productivity.

  6. Shuttle near-field environmental impacts - Conclusions and observations for launching at other locations

    NASA Technical Reports Server (NTRS)

    Koller, A. M., Jr.; Knott, W. M.

    1985-01-01

    Near field and far field environmental monitoring activities extending from the first launch of the Space Shuttle at the Kennedy Space Center have provided a database from which conclusions can now be drawn for short term, acute effects of launch and, to a lesser degree, long term cumulative effects on the natural environment. Data for the first 15 launches of the Space Shuttle from Kennedy Space Center Pad 39A are analyzed for statistical significance and reduced to graphical presentations of individual and collective disposition isopleths, summarization of observed environmental impacts (e.g., vegetation damage, fish kills), and supporting data from specialized experiments and laboratory analyses. Conclusions are drawn with regard to the near field environment at Pad A, the effects on the lagoonal complex, and the relationships of these data and conclusions to upcoming operations at Complex 39 Pad B where the environment is significantly different. The paper concludes with a subjective evaluation of the likely impacts at Vandenberg Space Launch Complex 6 for the first Shuttle launch next year.

  7. Western Aeronautical Test Range

    NASA Technical Reports Server (NTRS)

    Sakahara, Robert D.

    2008-01-01

    This viewgraph presentation reviews the work of the Western Aeronautical Test Range (WATR). NASA's Western Aeronautical Test Range is a network of facilities used to support aeronautical research, science missions, exploration system concepts, and space operations. The WATR resides at NASA's Dryden Flight Research Center located at Edwards Air Force Base, California. The WATR is a part of NASA's Corporate Management of Aeronautical Facilities and funded by the Strategic Capability Asset Program (SCAP). Maps show the general location of the WATR area that is used for aeronautical testing and evaluation. The products, services and facilities of WATR are discussed,

  8. Himalayan Mountain Range, India

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Snow is present the year round in most of the high Himalaya Mountain Range (33.0N, 76.5E). In this view taken at the onset of winter, the continuous snow line can be seen for hundreds of miles along the south face of the range in the Indian states of Punjab and Kashmir. The snow line is at about 12,000 ft. altitude but the deep Cenab River gorge is easily delineated as a break along the south edge of the snow covered mountains. '

  9. Satellite Laser Ranging operations

    NASA Technical Reports Server (NTRS)

    Pearlman, Michael R.

    1994-01-01

    Satellite Laser Ranging (SLR) is currently providing precision orbit determination for measurements of: 1) Ocean surface topography from satellite borne radar altimetry, 2) Spatial and temporal variations of the gravity field, 3) Earth and ocean tides, 4) Plate tectonic and regional deformation, 5) Post-glacial uplift and subsidence, 6) Variations in the Earth's center-of-mass, and 7) Variations in Earth rotation. SLR also supports specialized programs in time transfer and classical geodetic positioning, and will soon provide precision ranging to support experiments in relativity.

  10. Satellite laser ranging

    NASA Astrophysics Data System (ADS)

    Osorio, J. P.

    1992-03-01

    Laser ranging to satellites is one of the most precise methods for positio ning on the surface of the Earth. Reference is made to the need for precise posi tioning and to the improvement brought by the use of space techniques. Satellite Laser Ranging system is then described and in view of the high precision of the results derived from its measurements comments are made to some of the more important applications: high precision networks tectonic plate motion polar motion and earth''s rotation. Finally plans for system improvement in the near future are also presented.

  11. [Management of atopic dermatitis: practical guidelines suggested by the conclusion of systematic assessment in 500 children].

    PubMed

    Guillet, M H; Guillet, G

    2000-10-01

    Allergic management of AD may be worthwhile since allergy may trigger the disease. A systematic evaluation of sensitizations overtime and study of their clinical involvement in 500 children with AD was carried out, including minor, moderate, and severe patients (defined by clinical scores). Standardized methods assessed the possibility of contact dermatitis as well as IgE dependant allergies. Contact dermatitis concerned fragrances and nickel. Contact dermatitis was observed in minor and moderate AD with a progressive increase: 11% of children under 2 years and 58% in those over 15 years of age. Later in older children, sensitization to cosmetics and occupational allergens occurred in close connection with the specific environment. As for IgE sensitization, investigation should be electived advised in moderate and severe AD. Inhalant allergen sensitization was observed in 66% in moderate AD and 93% in severe AD in the group of 7 or 15 years. Clinical confrontation was a better indicator of cutaneous involvement than atopen patch-test. It mainly concerned respiratory symptoms. In severe AD, food allergy was constantly observed and presented as a marker for severe atopic dermatitis. The main trophallergen differ according to the age and cultural habits: in children under 2 years of age, eggs, peanuts, milk, fish were the main offending agents. Later, main trophallergens were wheat flour, shellfish. Although spontaneous decrease of food allergy is sometimes observed, it must be pointed out that food allergy may still persist as a triggering factor in teenagers as well as in adult-hood. The allergologic diagnosis of atopic dermatitis should not focus on IgE dependent sensitization without patch testing.

  12. Mosaic aging

    PubMed Central

    Walker, Lary C.; Herndon, James G.

    2010-01-01

    Summary Although all multicellular organisms undergo structural and functional deterioration with age, senescence is not a uniform process. Rather, each organism experiences a constellation of changes that reflect the heterogeneous effects of age on molecules, cells, organs and systems, an idiosyncratic pattern that we refer to as mosaic aging. Varying genetic, epigenetic and environmental factors (local and extrinsic) contribute to the aging phenotype in a given individual, and these agents influence the type and rate of functional decline, as well as the likelihood of developing age-associated afflictions such as cardiovascular disease, arthritis, cancer, and neurodegenerative disorders. Identifying key factors that drive aging, clarifying their activities in different systems, and in particular understanding how they interact will enhance our comprehension of the aging process, and could yield insights into the permissive role that senescence plays in the emergence of acute and chronic diseases of the elderly. PMID:20110150

  13. RADIO RANGING DEVICE

    DOEpatents

    Bogle, R.W.

    1960-11-22

    A description is given of a super-regenerative oscillator ranging device provided with radiating and receiving means and being capable of indicating the occurrence of that distance between itself and a reflecting object which so phases the received echo of energy of a preceding emitted oscillation that the intervals between oscillations become uniform.

  14. Agriculture, forest, and range

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The findings and recommendations of the panel for developing a satellite remote-sensing global information system in the next decade are reported. User requirements were identified in five categories: (1) cultivated crops, (2) land resources, (3)water resources, (4)forest management, and (5) range management. The benefits from the applications of satellite data are discussed.

  15. Agriculture, forestry, range resources

    NASA Technical Reports Server (NTRS)

    Crea, W. J.

    1974-01-01

    In the area of crop specie identification, it has been found that temporal data analysis, preliminary stratification, and unequal probability analysis were several of the factors that contributed to high identification accuracies. Single data set accuracies on fields of greater than 80,000 sq m (20 acres) are in the 70- to 90-percent range; however, with the use of temporal data, accuracies of 95 percent have been reported. Identification accuracy drops off significantly on areas of less than 80,000 sq m (20 acres) as does measurement accuracy. Forest stratification into coniferous and deciduous areas has been accomplished to a 90- to 95-percent accuracy level. Using multistage sampling techniques, the timber volume of a national forest district has been estimated to a confidence level and standard deviation acceptable to the Forest Service at a very favorable cost-benefit time ratio. Range specie/plant community vegetation mapping has been accomplished at various levels of success (69- to 90-percent accuracy). However, several investigators have obtained encouraging initial results in range biomass (forage production) estimation and range readiness predictions. Soil association map correction and soil association mapping in new area appear to have been proven feasible on large areas; however, testing in a complex soil area should be undertaken.

  16. Agriculture, forestry, range resources

    NASA Technical Reports Server (NTRS)

    Macdonald, R. B.

    1974-01-01

    The necessary elements to perform global inventories of agriculture, forestry, and range resources are being brought together through the use of satellites, sensors, computers, mathematics, and phenomenology. Results of ERTS-1 applications in these areas, as well as soil mapping, are described.

  17. Institutional Long Range Planning.

    ERIC Educational Resources Information Center

    Caldwell Community Coll. and Technical Inst., Lenoir, NC.

    Long-range institutional planning has been in effect at Caldwell Community College and Technical Institute since 1973. The first step in the process was the identification of planning areas: administration, organization, educational programs, learning resources, student services, faculty, facilities, maintenance/operation, and finances. The major…

  18. STDN ranging equipment

    NASA Technical Reports Server (NTRS)

    Jones, C. E.

    1975-01-01

    Final results of the Spaceflight Tracking and Data Network (STDN) Ranging Equipment program are summarized. Basic design concepts and final design approaches are described. Theoretical analyses which define requirements and support the design approaches are presented. Design verification criteria are delineated and verification test results are specified.

  19. Laser ranging data analysis

    NASA Technical Reports Server (NTRS)

    1992-01-01

    Center for Space Research efforts have focused on the near real-time analysis of Lageos laser ranging data and on the production of predictive ephemerides. The data are analyzed in terms of range bias, time bias, and internal precision, and estimates for the Earth orientation parameters X(sub p), Y(sub p) and UT1 are obtained. The results of these analyses are reported in a variety of formats. In addition several additional stations began sending not only quick-look observations but also normal points created on-site with new software. These normal points are transmitted in a new standard format different from either current quick-look or MERIT-II full-rate formats. Thus new preprocessing software was written and successfully tested on these data. Inspection of the Bendix produced Lageos full-rate normal points continued, with detailed analyses and filtering of all 1991 A and B release normal points for Lageos through the beginning of 1992. A summary of the combined full-rate and quick-look normal point data set created for 1991 is provided. New long-term ephemerides for Lageos satellite, as well as for Etalon-1 and Etalon-2 (the so-called high satellites used for laser ranging) were produced and distributed to the network stations in cooperation with the Crustal Dynamics Project and Eurolas. These predictions are used by essentially every laser ranging site obtaining regular returns from any of these three satellites.

  20. Front Range Branch Officers

    NASA Astrophysics Data System (ADS)

    The Front Range Branch of AGU has installed officers for 1990: Ray Noble, National Center for Atmospheric Research, chair; Sherry Oaks, U.S. Geological Survey, chair-elect; Howard Garcia, NOAA, treasurer; Catharine Skokan, Colorado School of Mines, secretary. JoAnn Joselyn of NOAA is past chair. Members at large are Wallace Campbell, NOAA; William Neff, USGS; and Stephen Schneider, NCAR.

  1. Fact Sheet: Range Complex

    NASA Technical Reports Server (NTRS)

    Cornelson, C.; Fretter, E.

    2004-01-01

    NASA Ames has a long tradition in leadership with the use of ballistic ranges and shock tubes for the purpose of studying the physics and phenomena associated with hypervelocity flight. Cutting-edge areas of research run the gamut from aerodynamics, to impact physics, to flow-field structure and chemistry. This legacy of testing began in the NACA era of the 1940's with the Supersonic Free Flight Tunnel, and evolved dramatically up through the late 1950s with the pioneering work in the Ames Hypersonic Ballistic Range. The tradition continued in the mid-60s with the commissioning of the three newest facilities: the Ames Vertical Gun Range (AVGR) in 1964, the Hypervelocity Free Flight Facility (HFFF) in 1965 and the Electric Arc Shock Tube (EAST) in 1966. Today the Range Complex continues to provide unique and critical testing in support of the Nation's programs for planetary geology and geophysics; exobiology; solar system origins; earth atmospheric entry, planetary entry, and aerobraking vehicles; and various configurations for supersonic and hypersonic aircraft.

  2. Electric vehicles: Driving range

    NASA Astrophysics Data System (ADS)

    Kempton, Willett

    2016-09-01

    For uptake of electric vehicles to increase, consumers' driving-range needs must be fulfilled. Analysis of the driving patterns of personal vehicles in the US now shows that today's electric vehicles can meet all travel needs on almost 90% of days from a single overnight charge.

  3. Mobile satellite ranging

    NASA Technical Reports Server (NTRS)

    Silverberg, E. C.

    1978-01-01

    A brief review of the constraints which have limited satellite ranging hardware and an outline of the steps which are underway to improve the status of the equipment in this area are given. In addition, some suggestions are presented for the utilization of newer instruments and for possible future research and development work in this area.

  4. The effect of state anxiety on paranoid ideation and jumping to conclusions. An experimental investigation.

    PubMed

    Lincoln, Tania M; Lange, Jennifer; Burau, Julia; Exner, Cornelia; Moritz, Steffen

    2010-11-01

    Theoretical models of persecutory delusions have emphasized the impact of reasoning biases and negative emotion at the early stages of symptom formation. However, the causal mechanisms remain unclear. This study tests the hypothesis that state anxiety will increase paranoid ideation and that this increase will be moderated by the level of individual vulnerability and mediated by the tendency to jump to conclusions. Healthy participants (n = 90) with varying levels of vulnerability (psychosis symptoms assessed by the Community Assessment of Psychic Experiences) were randomly assigned to either an anxiety or a nonanxiety condition. Anxiety was induced by pictures from the International Affective Picture System and by in sensu exposure to individual anxiety-provoking situations. During each condition, symptoms of paranoia were assessed by a state-adapted version of the Paranoia Checklist. Jumping to conclusions (JTC) was assessed using a modified version of the beads task. Overall, participants in the anxiety condition reported significantly more paranoid thoughts and showed more JTC than participants in the neutral condition. Participants with higher baseline vulnerability were more likely to show an increase in paranoia as reaction to the anxiety manipulation. Moreover, the association of anxiety and paranoia was mediated by the increased tendency to jump to conclusions in the beads task. The results are in line with a threat anticipation conceptualization of paranoia and provide evidence for an interaction of anxiety and reasoning biases in the development of paranoid beliefs. A combination of meta-cognitive training directed at reasoning biases and promoting emotion regulation skills might prove beneficial in preventing symptoms.

  5. The successful conclusion of the Deep Space 1 Mission: important results without a flashy title

    NASA Technical Reports Server (NTRS)

    Rayman, M. D.

    2002-01-01

    In September 2001, Deep Space 1 (DS1) completed a high-risk and flawless encounter with comet 19P/Borrelly. Its data provide a detailed view of this comet and offere surprising and exciting insights. With this successful conclusion of its extended mission, DS1 undertook a hyperextended mission. Following this period of extremely agressive testing, with no further technology or science objectives, the mission was terminated on December 18, 2001, with the powering off of the spacecraft's trnasmitter, although the receiver was left on. By the end of its mission, DS1 had returned a wealth of important science data and engineering data for future missions.

  6. Aging: overview.

    PubMed

    Harman, D

    2001-04-01

    Aging is a universal process that began with the origination of life about 3.5 billion years ago. Accumulation of the diverse deleterious changes produced by aging throughout the cells and tissues progressively impairs function and can eventually cause death. Aging changes can be attributed to development, genetic defects, the environment, disease, and an inborn process--the aging process. The chance of death at a given age serves as a measure of the average number of aging changes accumulated by persons of that age, that is, of physiologic age, and the rate of change of this measure as the rate of aging. Chances for death are decreased by improvements in general living conditions. As a result, during the past two millennia average life expectancy at birth (ALE-B), determined by the chances for death, of humans has risen from 30 years, in ancient Rome, to almost 80 years today in the developed countries. Chances for death in the developed countries are now near limiting values and ALE-Bs are approaching plateau values that are 6-9 years less than the potential maximum of about 85 years. Chances for death are now largely determined by the inherent aging process after age 28. Only 1.1% of female cohorts in Sweden die before this age; the remainder die off at an exponentially increasing rate with advancing age. The inherent aging process limits ALE-B to around 85 years, and the maximum life span (MLS) to about 122 years. Past efforts to increase ALE-B did not require an understanding of aging. Such knowledge will be necessary in the future to significantly increase ALE-B and MLS, and to satisfactorily ameliorate the medical, economic, and social problems associated with advancing age. The many theories advanced to account for aging should be used, to the extent it is feasible, to help with these important practical problems, including applications of the free radical theory of aging. Past measures evolved by societies to ensure adequate care for older individuals are

  7. Age, Intelligence, and Inspection Time.

    ERIC Educational Resources Information Center

    Nettelbeck, T.; Lally, M.

    1979-01-01

    Ten young males (aged 16-to-22 years) whose IQ scores ranged from 51 to 77 were compared on a simple discrimination task with ten male university students (aged 18-to-23 years) and 28 nonretarded male children (aged 7-to-11 years) in order to determine if reaction time is a consequence of mental retardation.

  8. Broken Robustness Analysis: How to make proper climate change conclusions in contradictory multimodal measurement contexts.

    NASA Astrophysics Data System (ADS)

    Keyser, V.

    2015-12-01

    Philosophers of science discuss how multiple modes of measurement can generate evidence for the existence and character of a phenomenon (Horwich 1982; Hacking 1983; Franklin and Howson 1984; Collins 1985; Sober 1989; Trout 1993; Culp 1995; Keeley 2002; Staley 2004; Weber 2005; Keyser 2012). But how can this work systematically in climate change measurement? Additionally, what conclusions can scientists and policy-makers draw when different modes of measurement fail to be robust by producing contradictory results? First, I present a new technical account of robust measurement (RAMP) that focuses on the physical independence of measurement processes. I detail how physically independent measurement processes "check each other's results." (This account is in contrast to philosophical accounts of robustness analysis that focus on independent model assumptions or independent measurement products or results.) Second, I present a puzzle about contradictory and divergent climate change measures, which has consistently re-emerged in climate measurement. This discussion will focus on land, drilling, troposphere, and computer simulation measures. Third, to systematically solve this climate measurement puzzle, I use RAMP in the context of drought measurement in order to generate a classification of measurement processes. Here, I discuss how multimodal precipitation measures—e.g., measures of precipitation deficit like the Standard Precipitation Index vs. air humidity measures like the Standardized Relative Humidity Index--can help with the classification scheme of climate change measurement processes. Finally, I discuss how this classification of measures can help scientists and policy-makers draw effective conclusions in contradictory multimodal climate change measurement contexts.

  9. Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of March 2013 meeting

    PubMed Central

    2013-01-01

    The Malaria Policy Advisory Committee to the World Health Organization met in Geneva, Switzerland from 13 to 15 March, 2013. This article provides a summary of the discussions, conclusions and recommendations from that meeting. Meeting sessions included: a review of the efficacy of artemisinin-based combination therapy in Guyana and Suriname; the outcomes from a consultation on non-malaria febrile illness; the outcomes from the second meeting of the Evidence Review Group on malaria burden estimation; an update on the review of the WHO Guidelines for the Treatment of Malaria; an update regarding progress on the constitution of the vector control Technical Expert Group; updates on the RTS, S/AS01 vaccine and the malaria vaccine technology roadmap; financing and resource allocation for malaria control; malaria surveillance and the need for a surveillance, monitoring and evaluation Technical Expert Group; criteria and classification related to malaria elimination; the next meeting of the Evidence Review Group on Intermittent Preventive Treatment in pregnancy; an update on the soon-to-be launched Elimination Scenario Planning Tool; and an update on the process for the Global Technical Strategy for Malaria Control and Elimination (2016–2025). Policy statements, position statements, and guidelines that arise from the MPAC meeting conclusions and recommendations will be formally issued and disseminated to World Health Organization Member States by the World Health Organization Global Malaria Programme. PMID:23787092

  10. Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of September 2013 meeting

    PubMed Central

    2013-01-01

    The Malaria Policy Advisory Committee to the World Health Organization held its fourth meeting in Geneva, Switzerland from 11 to 13 September, 2013. This article provides a summary of the discussions, conclusions and recommendations from that meeting. Meeting sessions included: recommendations for achieving universal coverage of long-lasting insecticide-treated nets; guidance on estimating the longevity of insecticide-treated nets; improving capacity in entomology and vector control; a review of the latest evidence on intermittent preventive treatment in pregnancy; improving dissemination of Malaria Policy Advisory Committee guidance; updates on the development of the global technical strategy for malaria control and elimination (2016–2025) and the global strategy for control and elimination of Plasmodium vivax; updates from the drug resistance and containment technical expert group, the evidence review group on malaria burden estimation, a consultation on malaria case management indicators, and the constitution of the surveillance, monitoring and evaluation technical expert group; subnational elimination criteria; and consideration for future evidence review groups, including diagnosis in low transmission settings and testing for Glucose-6-Phosphate Dehydrogenase Deficiency. Policy statements, position statements and guidelines that arise from the Malaria Policy Advisory Committee meeting conclusions and recommendations will be formally issued and disseminated to World Health Organization Member States by the World Health Organization Global Malaria Programme. PMID:24359206

  11. Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of eighth biannual meeting (September 2015).

    PubMed

    2016-02-24

    The Malaria Policy Advisory Committee (MPAC) to the World Health Organization held its eighth meeting in Geneva, Switzerland from 16 to 18 September 2015. This article provides a summary of the discussions, conclusions and meeting recommendations. Meeting sessions included: recommendations from the Evidence Review Group (ERG) on mass drug administration; recommendations from the ERG on malaria in pregnancy; recommendations on when to scale back vector control; feedback on the Plasmodium vivax technical brief and the recommendation for G6PD testing before treatment; updates on artemisinin and artemisinin-based combination therapy resistance and the Greater Mekong Subregion elimination strategy; an update from the working group on malaria terminology; and updates on malaria elimination in the World Health Organization European region, the ERG on malaria elimination, and World Health Organization reform to support innovation, efficiency and quality in vector control tools. Policy statements, position statements, and guidelines that arise from the MPAC meeting conclusions and recommendations will be issued formally and disseminated to World Health Organization Member States by the World Health Organization Global Malaria Programme.

  12. Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of March 2013 meeting.

    PubMed

    2013-01-01

    The Malaria Policy Advisory Committee to the World Health Organization met in Geneva, Switzerland from 13 to 15 March, 2013. This article provides a summary of the discussions, conclusions and recommendations from that meeting.Meeting sessions included: a review of the efficacy of artemisinin-based combination therapy in Guyana and Suriname; the outcomes from a consultation on non-malaria febrile illness; the outcomes from the second meeting of the Evidence Review Group on malaria burden estimation; an update on the review of the WHO Guidelines for the Treatment of Malaria; an update regarding progress on the constitution of the vector control Technical Expert Group; updates on the RTS, S/AS01 vaccine and the malaria vaccine technology roadmap; financing and resource allocation for malaria control; malaria surveillance and the need for a surveillance, monitoring and evaluation Technical Expert Group; criteria and classification related to malaria elimination; the next meeting of the Evidence Review Group on Intermittent Preventive Treatment in pregnancy; an update on the soon-to-be launched Elimination Scenario Planning Tool; and an update on the process for the Global Technical Strategy for Malaria Control and Elimination (2016-2025).Policy statements, position statements, and guidelines that arise from the MPAC meeting conclusions and recommendations will be formally issued and disseminated to World Health Organization Member States by the World Health Organization Global Malaria Programme.

  13. Better environmental data may reverse conclusions about niche- and dispersal-based processes in community assembly.

    PubMed

    Chang, Li-Wan; Zeleny, David; Li, Ching-Feng; Chiu, Shau-Ting; Hsieh, Chang-Fu

    2013-10-01

    Variation partitioning of species composition into components explained by environmental and spatial variables is often used to identify a signature of niche- and dispersal-based processes in community assembly. Such interpretation, however, strongly depends on the quality of the environmental data available. In recent studies conducted in forest dynamics plots, the environment was represented only by readily available topographical variables. Using data from a subtropical broad-leaved dynamics plot in Taiwan, we focus on the question of how would the conclusion about importance of niche- and dispersal-based processes change if soil variables are also included in the analysis. To gain further insight, we introduced multiscale decomposition of a pure spatial component [c] in variation partitioning. Our results indicate that, if only topography is included, dispersal-based processes prevail, while including soil variables reverses this conclusion in favor of niche-based processes. Multiscale decomposition of [c] shows that if only topography was included, broad-scaled spatial variation prevails in [c], indicating that other as yet unmeasured environmental variables can be important. However, after also including soil variables this pattern disappears, increasing importance of meso- and fine-scaled spatial patterns indicative of dispersal processes. PMID:24358699

  14. Light beam range finder

    DOEpatents

    McEwan, T.E.

    1998-06-16

    A ``laser tape measure`` for measuring distance is disclosed which includes a transmitter such as a laser diode which transmits a sequence of electromagnetic pulses in response to a transmit timing signal. A receiver samples reflections from objects within the field of the sequence of visible electromagnetic pulses with controlled timing, in response to a receive timing signal. The receiver generates a sample signal in response to the samples which indicates distance to the object causing the reflections. The timing circuit supplies the transmit timing signal to the transmitter and supplies the receive timing signal to the receiver. The receive timing signal causes the receiver to sample the reflection such that the time between transmission of pulses in the sequence in sampling by the receiver sweeps over a range of delays. The transmit timing signal causes the transmitter to transmit the sequence of electromagnetic pulses at a pulse repetition rate, and the received timing signal sweeps over the range of delays in a sweep cycle such that reflections are sampled at the pulse repetition rate and with different delays in the range of delays, such that the sample signal represents received reflections in equivalent time. The receiver according to one aspect of the invention includes an avalanche photodiode and a sampling gate coupled to the photodiode which is responsive to the received timing signal. The transmitter includes a laser diode which supplies a sequence of visible electromagnetic pulses. A bright spot projected on to the target clearly indicates the point that is being measured, and the user can read the range to that point with precision of better than 0.1%. 7 figs.

  15. Light beam range finder

    DOEpatents

    McEwan, Thomas E.

    1998-01-01

    A "laser tape measure" for measuring distance which includes a transmitter such as a laser diode which transmits a sequence of electromagnetic pulses in response to a transmit timing signal. A receiver samples reflections from objects within the field of the sequence of visible electromagnetic pulses with controlled timing, in response to a receive timing signal. The receiver generates a sample signal in response to the samples which indicates distance to the object causing the reflections. The timing circuit supplies the transmit timing signal to the transmitter and supplies the receive timing signal to the receiver. The receive timing signal causes the receiver to sample the reflection such that the time between transmission of pulses in the sequence in sampling by the receiver sweeps over a range of delays. The transmit timing signal causes the transmitter to transmit the sequence of electromagnetic pulses at a pulse repetition rate, and the received timing signal sweeps over the range of delays in a sweep cycle such that reflections are sampled at the pulse repetition rate and with different delays in the range of delays, such that the sample signal represents received reflections in equivalent time. The receiver according to one aspect of the invention includes an avalanche photodiode and a sampling gate coupled to the photodiode which is responsive to the received timing signal. The transmitter includes a laser diode which supplies a sequence of visible electromagnetic pulses. A bright spot projected on to the target clearly indicates the point that is being measured, and the user can read the range to that point with precision of better than 0.1%.

  16. Overview, conclusions, and recommendations of the IPCS collaborative study on complex mixtures.

    PubMed

    Claxton, L D; Douglas, G; Krewski, D; Lewtas, J; Matsushita, H; Rosenkranz, H

    1992-01-01

    The International Programme on Chemical Safety (IPCS) sponsored an international collaborative study to examine the variability associated with the extraction and bioassay of standard reference materials (SRMs) that are complex environmental mixtures provided by the U.S. National Institute of Standards and Technology (NIST). The study was also intended to evaluate the feasibility of establishing bioassay reference values and ranges for the SRMs. Twenty laboratories from North America, Europe, and Japan participated in the study. As part of the mandatory core protocol, each laboratory extracted the organic material from two particulate samples and bioassayed these extracts. A coal tar polycyclic aromatic hydrocarbon (PAH) solution and two mutagenic control compounds were also subjected to bioassay without prior extraction by the participating laboratories. The bioassay used was the Salmonella/microsomal plate incorporation assay. For the optional portion of the study, a laboratory was free to use the SRMs for any type of exploratory research. The primary purpose of the required portion of the study was to estimate the intra- and inter-laboratory variability in mutagenic potencies of the test materials and to determine whether or not the NIST mixtures could be used as reference materials by others performing the Salmonella assay. Repeatability (intra-laboratory variance) of the bioassay results ranged from 16% to 88% depending on the SRM and the bioassay conditions (tester strain and metabolic activation), whereas reproducibility (inter-laboratory variance) ranged from 33% to 152%. Between-laboratory variability was the main source of variation accounting for approximately 55-95% of the total variation for the three environmental samples. Variation in the mutagenic potency of the control compounds was comparable, with the exception of 1-nitropyrene for which the reproducibility ranged from 127% to 132%. In summary, NIST SRMs provided useful materials for an

  17. Multiple pancreatic metastases from malignant melanoma: Conclusive diagnosis with endoscopic ultrasound-guided fine needle aspiration.

    PubMed

    Jana, Tanima; Caraway, Nancy P; Irisawa, Atsushi; Bhutani, Manoop S

    2015-01-01

    Pancreatic metastases are rare, ranging from 2% to 5% of pancreatic malignancies. Differentiating a primary pancreatic malignancy from a metastasis can be difficult due to similarities on imaging findings, but is crucial to ensure proper treatment. Although transabdominal ultrasound, computed tomography, and magnetic resonance imaging provide useful images, endoscopic ultrasound (EUS) with fine needle aspiration (FNA) is often needed to provide a cytologic diagnosis. Here, we present a unique case of malignant melanoma with pancreatic metastases. It is important for clinicians to recognize the possibility of melanoma metastasizing to the pancreas and the role of EUS with FNA in providing cytological confirmation.

  18. Multiple pancreatic metastases from malignant melanoma: Conclusive diagnosis with endoscopic ultrasound-guided fine needle aspiration.

    PubMed

    Jana, Tanima; Caraway, Nancy P; Irisawa, Atsushi; Bhutani, Manoop S

    2015-01-01

    Pancreatic metastases are rare, ranging from 2% to 5% of pancreatic malignancies. Differentiating a primary pancreatic malignancy from a metastasis can be difficult due to similarities on imaging findings, but is crucial to ensure proper treatment. Although transabdominal ultrasound, computed tomography, and magnetic resonance imaging provide useful images, endoscopic ultrasound (EUS) with fine needle aspiration (FNA) is often needed to provide a cytologic diagnosis. Here, we present a unique case of malignant melanoma with pancreatic metastases. It is important for clinicians to recognize the possibility of melanoma metastasizing to the pancreas and the role of EUS with FNA in providing cytological confirmation. PMID:26020050

  19. Conclusive evidence of abrupt coagulation inside the void during cyclic nanoparticle formation in reactive plasma

    NASA Astrophysics Data System (ADS)

    van de Wetering, F. M. J. H.; Nijdam, S.; Beckers, J.

    2016-07-01

    In this letter, we present scanning electron microscopy (SEM) results that confirm in a direct way our earlier explanation of an abrupt coagulation event as the cause for the void hiccup. In a recent paper, we reported on the fast and interrupted expansion of voids in a reactive dusty argon-acetylene plasma. The voids appeared one after the other, each showing a peculiar, though reproducible, behavior of successive periods of fast expansion, abrupt contraction, and continued expansion. The abrupt contraction was termed "hiccup" and was related to collective coagulation of a new generation of nanoparticles growing in the void using relatively indirect methods: electron density measurements and optical emission spectroscopy. In this letter, we present conclusive evidence using SEM of particles collected at different moments in time spanning several growth cycles, which enables us to follow the nanoparticle formation process in great detail.

  20. Sex differences in moral reasoning: response to Walker's (1984) conclusion that there are none.

    PubMed

    Baumrind, D

    1986-04-01

    Data from the Family Socialization and Developmental Competence Project are used to probe Walker's conclusion that there are no sex differences in moral reasoning. Ordinal and nominal nonparametric statistics result in a complex but theoretically meaningful network of relationships among sex, educational level, and Kohlberg stage score level, with the presence and direction of sex differences in stage score level dependent on educational level. The effects on stage score level of educational level and working status are also shown to differ for men and women. Reasons are considered for not accepting Walker's dismissal of studies that use (a) a pre-1983 scoring manual, or (b) fail to control for education. The problems presented to Kohlberg's theory by the significant relationship between educational and stage score levels in the general population are discussed, particularly as these apply to the postconventional level of moral reasoning.

  1. Results and conclusions: perception sensor study for high speed autonomous operations

    NASA Astrophysics Data System (ADS)

    Schneider, Anne; LaCelle, Zachary; Lacaze, Alberto; Murphy, Karl; Close, Ryan

    2016-05-01

    Previous research has presented work on sensor requirements, specifications, and testing, to evaluate the feasibility of increasing autonomous vehicle system speeds. Discussions included the theoretical background for determining sensor requirements, and the basic test setup and evaluation criteria for comparing existing and prototype sensor designs. This paper will present and discuss the continuation of this work. In particular, this paper will focus on analyzing the problem via a real-world comparison of various sensor technology testing results, as opposed to previous work that utilized more of a theoretical approach. LADAR/LIDAR, radar, visual, and infrared sensors are considered in this research. Results are evaluated against the theoretical, desired perception specifications. Conclusions for utilizing a suite of perception sensors, to achieve the goal of doubling ground vehicle speeds, is also discussed.

  2. Conclusions Regarding Cross-Group Differences in Happiness Depend on Difficulty of Reaching Respondents*

    PubMed Central

    Heffetz, Ori; Rabin, Matthew

    2015-01-01

    A growing literature explores differences in subjective well-being across demographic groups, often relying on surveys with high nonresponse rates. By using the reported number of call attempts made to participants in the University of Michigan’s Surveys of Consumers, we show that comparisons among easy-to-reach respondents differ from comparisons among hard-to-reach ones. Notably, easy-to-reach women are happier than easy-to-reach men, but hard-to-reach men are happier than hard-to-reach women, and conclusions of a survey could reverse with more attempted calls. Better alternatives to comparing group sample averages might include putting greater weight on hard-to-reach respondents or even extrapolating trends in responses. PMID:26316655

  3. Remotely and Conclusively Mapping One Finite Set of Qudit States onto Another Assisted by Qubit Entanglements

    NASA Astrophysics Data System (ADS)

    Chen, Li-Bing; Lu, Hong

    2016-05-01

    Alice and Bob are two remote parties. We propose a probabilistic method which allows Alice to map remotely and conclusively Bob's set of nonorthogonal symmetric d-level quantum states onto another. The procedure we use is a remote positive operator valued measurement (POVM) in Bob's (2 d-1)-level direct sum space. We construct a quantum network for implementing this (2 d-1)-level remote nonunitary POVM with ( d-1) two-level remote unitary rotations. The fact that the two-level remote rotation, which is hired to rotate remotely a basis vector, can been implementing rapidly using only one ebit (a two-level Einstein-Podolsky-Rosen (EPR) pair) and one cbit (classical communication) is notable. This scheme is simpler but with less resource, which will make it more feasible and suitable for large-scale quantum network.

  4. The six most essential questions in psychiatric diagnosis: a pluralogue. Part 4: general conclusion

    PubMed Central

    2012-01-01

    In the conclusion to this multi-part article I first review the discussions carried out around the six essential questions in psychiatric diagnosis – the position taken by Allen Frances on each question, the commentaries on the respective question along with Frances’ responses to the commentaries, and my own view of the multiple discussions. In this review I emphasize that the core question is the first – what is the nature of psychiatric illness – and that in some manner all further questions follow from the first. Following this review I attempt to move the discussion forward, addressing the first question from the perspectives of natural kind analysis and complexity analysis. This reflection leads toward a view of psychiatric disorders – and future nosologies – as far more complex and uncertain than we have imagined. PMID:23249629

  5. The use of verb information in parsing: different statistical analyses lead to contradictory conclusions.

    PubMed

    Kennison, Shelia M

    2009-08-01

    The research investigated how comprehenders use verb information during syntactic parsing. Two reading experiments investigated the relationship between verb-specific variables and reading time. These experiments were close replications of prior work; however, two statistical techniques were used, rather than one. These were item-by-item correlations and participant-by-participant regression. In Experiment 1, reading time was measured using a self-paced moving window. In Experiment 2, eye movements were recorded during reading. The results of both experiments showed that the results of two types of statistical analyses support contradictory conclusions. The analyses involving participant-by-participant regression analyses provided no evidence for the early use of verb information in parsing and support syntax-first approaches to parsing. In contrast, the results of item-by-item correlation were consistent with the prior research, supporting the view that verb information can guide initial parsing decisions. Implications for theories of parsing are discussed.

  6. Judgments of learning reflect encoding fluency: conclusive evidence for the ease-of-processing hypothesis.

    PubMed

    Undorf, Monika; Erdfelder, Edgar

    2011-09-01

    According to the ease-of-processing hypothesis, judgments of learning (JOLs) rely on the ease with which items are committed to memory during encoding--that is, encoding fluency. Conclusive evidence for this hypothesis does not yet exist because encoding fluency and item difficulty have been confounded in all previous studies. To disentangle the effects of encoding fluency and item difficulty on JOLs, we used a variant of the learner-observer-judge method in which participants observed the study phase of another participant and indicated his or her JOLs. At the same time, the to-be-studied word pairs were concealed by strings of symbols. Our experiment revealed that participants use self-paced study time as a cue for JOLs when they themselves have studied and recalled word pairs before. This metacognitive monitoring of study time provides strong support for the ease-of-processing hypothesis.

  7. Studies of the mutagenic effects of styrene to man: conclusions for the surveillance of styrene-exposed workers

    NASA Astrophysics Data System (ADS)

    Rothe, Roland; Schmidt, P.; Grummt, T.; Grummt, H. J.; Kersten, N.; Weigmann, Hans-Juergen

    1993-03-01

    One hundred fifty-six styrene-exposed workers had a fourfold higher rate of chromosome aberrations in peripheral lymphocytes than the control persons. The parameters of clinical chemistry (liver, kidney, and blood) remained in the normal range. Further analyses of the data of this study revealed no connections of the degree of effects in clinical chemistry and the exposure level. But a connection exists to the duration of exposure (3 - 26 years): in the comparison of the mean values (all mean values within the normal range) significant differences were found between long-term exposed workers (more than ten years) and control persons. In the higher age groups (above 45 years) also the GAP-rate differences are more pronounced. Seventy percent of the TWA-values were found to be below 85 mg/m3; the arithmetic mean of the TWA-values 72,3 mg/m3. A health surveillance program to styrene-exposed workers is to be reviewed (clinical chemistry and genetic effects). Proposals concerning both problems are presented.

  8. Parylene C Aging Studies.

    SciTech Connect

    Achyuthan, Komandoor; Sawyer, Patricia Sue.; Mata, Guillermo Adrian; White II, Gregory Von; Bernstein, Robert

    2014-09-01

    Parylene C is used in a device because of its conformable deposition and other advantages. Techniques to study Parylene C aging were developed, and "lessons learned" that could be utilized for future studies are the result of this initial study. Differential Scanning Calorimetry yielded temperature ranges for Parylene C aging as well as post-deposition treatment. Post-deposition techniques are suggested to improve Parylene C performance. Sample preparation was critical to aging regimen. Short-term (%7E40 days) aging experiments with free standing and ceramic-supported Parylene C films highlighted "lessons learned" which stressed further investigations in order to refine sample preparation (film thickness, single sided uniform coating, machine versus laser cutting, annealing time, temperature) and testing issues ("necking") for robust accelerated aging of Parylene C.

  9. Contributions of atmospheric nitrogen deposition to U.S. estuaries: Summary and conclusions: Chapter 8

    USGS Publications Warehouse

    Stacey, Paul E.; Greening, Holly; Kremer, James N.; Peterson, David; Tomasko, David A.; Valigura, Richard A.; Alexander, Richard B.; Castro, Mark S.; Meyers, Tilden P.; Paerl, Hans W.; Stacey, Paul E.; Turner, R. Eugene

    2001-01-01

    A NOAA project was initiated in 1998, with support from the U.S. EPA, to develop state-of-the-art estimates of atmospheric N deposition to estuarine watersheds and water surfaces and its delivery to the estuaries. Work groups were formed to address N deposition rates, indirect (from the watershed) yields from atmospheric and other anthropogenic sources, and direct deposition on the estuarine waterbodies, and to evaluate the levels of uncertainty within the estimates. Watershed N yields were estimated using both a land-use based process approach and a national (SPARROW) model, compared to each other, and compared to estimates of N yield from the literature. The total N yields predicted by the national model were similar to values found in the literature and the land-use derived estimates were consistently higher. Atmospheric N yield estimates were within a similar range for the two approaches, but tended to be higher in the land-use based estimates and were not wellcorrelated. Median atmospheric N yields were around 15% of the total N yield for both groups, but ranged as high as 60% when both direct and indirect deposition were considered. Although not the dominant source of anthropogenic N, atmospheric N is, and will undoubtedly continue to be, an important factor in culturally eutrophied estuarine systems, warranting additional research and management attention.

  10. Definition of sampling units begets conclusions in ecology: the case of habitats for plant communities.

    PubMed

    Mörsdorf, Martin A; Ravolainen, Virve T; Støvern, Leif Einar; Yoccoz, Nigel G; Jónsdóttir, Ingibjörg Svala; Bråthen, Kari Anne

    2015-01-01

    In ecology, expert knowledge on habitat characteristics is often used to define sampling units such as study sites. Ecologists are especially prone to such approaches when prior sampling frames are not accessible. Here we ask to what extent can different approaches to the definition of sampling units influence the conclusions that are drawn from an ecological study? We do this by comparing a formal versus a subjective definition of sampling units within a study design which is based on well-articulated objectives and proper methodology. Both approaches are applied to tundra plant communities in mesic and snowbed habitats. For the formal approach, sampling units were first defined for each habitat in concave terrain of suitable slope using GIS. In the field, these units were only accepted as the targeted habitats if additional criteria for vegetation cover were fulfilled. For the subjective approach, sampling units were defined visually in the field, based on typical plant communities of mesic and snowbed habitats. For each approach, we collected information about plant community characteristics within a total of 11 mesic and seven snowbed units distributed between two herding districts of contrasting reindeer density. Results from the two approaches differed significantly in several plant community characteristics in both mesic and snowbed habitats. Furthermore, differences between the two approaches were not consistent because their magnitude and direction differed both between the two habitats and the two reindeer herding districts. Consequently, we could draw different conclusions on how plant diversity and relative abundance of functional groups are differentiated between the two habitats depending on the approach used. We therefore challenge ecologists to formalize the expert knowledge applied to define sampling units through a set of well-articulated rules, rather than applying it subjectively. We see this as instrumental for progress in ecology as only rules

  11. Definition of sampling units begets conclusions in ecology: the case of habitats for plant communities

    PubMed Central

    Ravolainen, Virve T.; Støvern, Leif Einar; Yoccoz, Nigel G.; Jónsdóttir, Ingibjörg Svala; Bråthen, Kari Anne

    2015-01-01

    In ecology, expert knowledge on habitat characteristics is often used to define sampling units such as study sites. Ecologists are especially prone to such approaches when prior sampling frames are not accessible. Here we ask to what extent can different approaches to the definition of sampling units influence the conclusions that are drawn from an ecological study? We do this by comparing a formal versus a subjective definition of sampling units within a study design which is based on well-articulated objectives and proper methodology. Both approaches are applied to tundra plant communities in mesic and snowbed habitats. For the formal approach, sampling units were first defined for each habitat in concave terrain of suitable slope using GIS. In the field, these units were only accepted as the targeted habitats if additional criteria for vegetation cover were fulfilled. For the subjective approach, sampling units were defined visually in the field, based on typical plant communities of mesic and snowbed habitats. For each approach, we collected information about plant community characteristics within a total of 11 mesic and seven snowbed units distributed between two herding districts of contrasting reindeer density. Results from the two approaches differed significantly in several plant community characteristics in both mesic and snowbed habitats. Furthermore, differences between the two approaches were not consistent because their magnitude and direction differed both between the two habitats and the two reindeer herding districts. Consequently, we could draw different conclusions on how plant diversity and relative abundance of functional groups are differentiated between the two habitats depending on the approach used. We therefore challenge ecologists to formalize the expert knowledge applied to define sampling units through a set of well-articulated rules, rather than applying it subjectively. We see this as instrumental for progress in ecology as only rules

  12. Tonopah Test Range Post-Closure Inspection Annual Report, Tonopah Test Range, Nevada, Calendar Year 2003

    SciTech Connect

    U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; Bechtel Nevada

    2004-04-01

    This post-closure inspection report provides documentation of the semiannual inspection activities, maintenance and repair activities, and conclusions and recommendations for calendar year 2003 for eight corrective action units located on the Tonopah Test Range, Nevada.

  13. Gas cooking range

    SciTech Connect

    Narang, R.K.; Narang, K.

    1984-02-14

    An energy-efficient gas cooking range features an oven section with improved heat circulation and air preheat, a compact oven/broiler burner, a smoke-free drip pan, an efficient piloted ignition, flame-containing rangetop burner rings, and a small, portable oven that can be supported on the burner rings. Panels spaced away from the oven walls and circulation fans provide very effective air flow within the oven. A gas shutoff valve automatically controls the discharge of heated gases from the oven so that they are discharged only when combustion is occurring.

  14. Gamma Frequency–Range Abnormalities to Auditory Stimulation in Schizophrenia

    PubMed Central

    Kwon, Jun Soo; O’Donnell, Brian F.; Wallenstein, Gene V.; Greene, Robert W.; Hirayasu, Yoshio; Nestor, Paul G.; Hasselmo, Michael E.; Potts, Geoffrey F.; Shenton, Martha E.; McCarley, Robert W.

    2010-01-01

    Background Basic science studies at the neuronal systems level have indicated that gamma-range (30–50 Hz) neural synchronization may be a key mechanism of information processing in neural networks, reflecting integration of various features of an object. Furthermore, gamma-range synchronization is thought to depend on the glutamatergically mediated interplay between excitatory projection neurons and inhibitory neurons utilizing g-aminobutyric acid (GABA), which postmortem studies suggest may be abnormal in schizophrenia. We therefore tested whether auditory neural networks in patients with schizophrenia could support gamma-range synchronization. Methods Synchronization of the electroencephalogram (EEG) to different rates (20–40 Hz) of auditory stimulation was recorded from 15 patients with schizophrenia and 15 sex-, age-, and handedness-matched control subjects. The EEG power at each stimulation frequency was compared between groups. The time course of the phase relationship between each stimulus and EEG peak was also evaluated for gamma-range (40 Hz) stimulation. Results Schizophrenic patients showed reduced EEG power at 40 Hz, but not at lower frequencies of stimulation. In addition, schizophrenic patients showed delayed onset of phase synchronization and delayed desynchronization to the click train. Conclusions These data provide new information on selective deficits in early-stage sensory processing in schizophrenia, a failure to support the entrainment of intrinsic gamma-frequency oscillators. The reduced EEG power at 40 Hz in schizophrenic patients may reflect a dysfunction of the recurrent inhibitory drive on auditory neural networks. PMID:10565499

  15. The pitfall of experimenting on the web: How unattended selective attrition leads to surprising (yet false) research conclusions.

    PubMed

    Zhou, Haotian; Fishbach, Ayelet

    2016-10-01

    The authors find that experimental studies using online samples (e.g., MTurk) often violate the assumption of random assignment, because participant attrition-quitting a study before completing it and getting paid-is not only prevalent, but also varies systemically across experimental conditions. Using standard social psychology paradigms (e.g., ego-depletion, construal level), they observed attrition rates ranging from 30% to 50% (Study 1). The authors show that failing to attend to attrition rates in online panels has grave consequences. By introducing experimental confounds, unattended attrition misled them to draw mind-boggling yet false conclusions: that recalling a few happy events is considerably more effortful than recalling many happy events, and that imagining applying eyeliner leads to weight loss (Study 2). In addition, attrition rate misled them to draw a logical yet false conclusion: that explaining one's view on gun rights decreases progun sentiment (Study 3). The authors offer a partial remedy (Study 4) and call for minimizing and reporting experimental attrition in studies conducted on the Web. (PsycINFO Database Record

  16. The pitfall of experimenting on the web: How unattended selective attrition leads to surprising (yet false) research conclusions.

    PubMed

    Zhou, Haotian; Fishbach, Ayelet

    2016-10-01

    The authors find that experimental studies using online samples (e.g., MTurk) often violate the assumption of random assignment, because participant attrition-quitting a study before completing it and getting paid-is not only prevalent, but also varies systemically across experimental conditions. Using standard social psychology paradigms (e.g., ego-depletion, construal level), they observed attrition rates ranging from 30% to 50% (Study 1). The authors show that failing to attend to attrition rates in online panels has grave consequences. By introducing experimental confounds, unattended attrition misled them to draw mind-boggling yet false conclusions: that recalling a few happy events is considerably more effortful than recalling many happy events, and that imagining applying eyeliner leads to weight loss (Study 2). In addition, attrition rate misled them to draw a logical yet false conclusion: that explaining one's view on gun rights decreases progun sentiment (Study 3). The authors offer a partial remedy (Study 4) and call for minimizing and reporting experimental attrition in studies conducted on the Web. (PsycINFO Database Record PMID:27295328

  17. Galvanizing action: conclusions and next steps for mainstreaming zinc interventions in public health programs.

    PubMed

    Brown, Kenneth H; Baker, Shawn K

    2009-03-01

    This paper summarizes the results of the foregoing reviews of the impact of different intervention strategies designed to enhance zinc nutrition, including supplementation, fortification, and dietary diversification or modification. Current evidence indicates a beneficial impact of such interventions on zinc status and zinc-related functional outcomes. Preventive zinc supplementation reduces the incidence of diarrhea and acute lower respiratory tract infection among young children, decreases mortality of children over 12 months of age, and increases growth velocity. Therapeutic zinc supplementation during episodes of diarrhea reduces the duration and severity of illness. Zinc fortification increases zinc intake and total absorbed zinc, and recent studies are beginning to confirm a positive impact of zinc fortification on indicators of population zinc status. To assist with the development of zinc intervention programs, more information is needed on the prevalence of zinc deficiency in different countries, and rigorous evaluations of the effectiveness of large-scale zinc intervention programs should be planned. Recommended steps for scaling up zinc intervention programs, with or without other micronutrients, are described. In summary, there is now clear evidence of the benefit of selected interventions to reduce the risk of zinc deficiency, and a global commitment is urgently needed to conduct systematic assessments of population zinc status and to develop interventions to control zinc deficiency in the context of existing public health and nutrition programs.

  18. Aging Parents.

    ERIC Educational Resources Information Center

    Frazier, Billie H.

    This document contains a brief bibliography of peer-reviewed literature, with abstracts, on aging parents. It is one of 12 bibliographies on aging prepared by the National Agricultural Library for its "Pathfinders" series of publications. Topics covered by the other 11 bibliographies include adult children, dementia and Alzheimer's disease in the…

  19. Experimental Test of Momentum Cooling Model Predictions at COSY and Conclusions for WASA and HESR

    SciTech Connect

    Stockhorst, H.; Stassen, R.; Maier, R.; Prasuhn, D.; Katayama, T.; Thorndahl, L

    2007-11-07

    The High-Energy Storage Ring (HESR) of the future International Facility for Antiproton and Ion Research (FAIR) at GSI in Darmstadt is planned as an anti-proton cooler ring in the momentum range from 1.5 to 15 GeV/c. An important and challenging feature of the new facility is the combination of highly dense phase space cooled beams with internal targets. A detailed numerical and analytical approach to the Fokker-Planck equation for longitudinal filter cooling including the beam-target interaction has been carried out to demonstrate the stochastic cooling capability. To gain confidence in the model predictions a series of experimental stochastic cooling studies with the internal target ANKE at COSY have been carried out. A remarkable agreement between model and experiment was achieved. On this basis longitudinal stochastic cooling simulations were performed to predict the possibilities and limits of cooling when the newly installed WASA Pellet-target is operated.

  20. Western Aeronautical Test Range

    NASA Technical Reports Server (NTRS)

    Sakahara, Robert D.

    2008-01-01

    NASA's Western Aeronautical Test Range (WATR) is a network of facilities used to support aeronautical research, science missions, exploration system concepts, and space operations. The WATR resides at NASA's Dryden Flight Research Center located at Edwards Air Force Base, California. The WATR is a part of NASA's Corporate Management of Aeronautical Facilities and funded by the Strategic Capability Asset Program (SCAP). It is managed by the Aeronautics Test Program (ATP) of the Aeronautics Research Mission Directorate (ARMD) to provide the right facility at the right time. NASA is a tenant on Edwards Air Force Base and has an agreement with the Air Force Flight Test Center to use the land and airspace controlled by the Department of Defense (DoD). The topics include: 1) The WATR supports a variety of vehicles; 2) Dryden shares airspace with the AFFTC; 3) Restricted airspace, corridors, and special use areas are available for experimental aircraft; 4) WATR Products and Services; 5) WATR Support Configuration; 6) Telemetry Tracking; 7) Time Space Positioning; 8) Video; 9) Voice Communication; 10) Mobile Operations Facilities; 11) Data Processing; 12) Mission Control Center; 13) Real-Time Data Analysis; and 14) Range Safety.

  1. Monocular visual ranging

    NASA Astrophysics Data System (ADS)

    Witus, Gary; Hunt, Shawn

    2008-04-01

    The vision system of a mobile robot for checkpoint and perimeter security inspection performs multiple functions: providing surveillance video, providing high resolution still images, and providing video for semi-autonomous visual navigation. Mid-priced commercial digital cameras support the primary inspection functions. Semi-autonomous visual navigation is a tertiary function whose purpose is to reduce the burden of teleoperation and free the security personnel for their primary functions. Approaches to robot visual navigation require some form of depth perception for speed control to prevent the robot from colliding with objects. In this paper present the initial results of an exploration of the capabilities and limitations of using a single monocular commercial digital camera for depth perception. Our approach combines complementary methods in alternating stationary and moving behaviors. When the platform is stationary, it computes a range image from differential blur in the image stack collected at multiple focus settings. When the robot is moving, it extracts an estimate of range from the camera auto-focus function, and combines this with an estimate derived from angular expansion of a constellation of visual tracking points.

  2. Range Process Simulation Tool

    NASA Technical Reports Server (NTRS)

    Phillips, Dave; Haas, William; Barth, Tim; Benjamin, Perakath; Graul, Michael; Bagatourova, Olga

    2005-01-01

    Range Process Simulation Tool (RPST) is a computer program that assists managers in rapidly predicting and quantitatively assessing the operational effects of proposed technological additions to, and/or upgrades of, complex facilities and engineering systems such as the Eastern Test Range. Originally designed for application to space transportation systems, RPST is also suitable for assessing effects of proposed changes in industrial facilities and large organizations. RPST follows a model-based approach that includes finite-capacity schedule analysis and discrete-event process simulation. A component-based, scalable, open architecture makes RPST easily and rapidly tailorable for diverse applications. Specific RPST functions include: (1) definition of analysis objectives and performance metrics; (2) selection of process templates from a processtemplate library; (3) configuration of process models for detailed simulation and schedule analysis; (4) design of operations- analysis experiments; (5) schedule and simulation-based process analysis; and (6) optimization of performance by use of genetic algorithms and simulated annealing. The main benefits afforded by RPST are provision of information that can be used to reduce costs of operation and maintenance, and the capability for affordable, accurate, and reliable prediction and exploration of the consequences of many alternative proposed decisions.

  3. Japanese spousal smoking study revisited: how a tobacco industry funded paper reached erroneous conclusions

    PubMed Central

    Yano, E

    2005-01-01

    Objectives: To provide a participant's account of the development of a paper commissioned by the tobacco industry examining the reliability of self reported smoking status; to redress the distorted report of this Japanese spousal smoking study which evaluated the reliability and validity of self reported smoking status, and estimated confounding by diet and lifestyle factors. Design: Repeated interviews on smoking status and its verification by environmental and biological markers for environmental tobacco smoke (ETS) exposure. Setting: Urban wives in Osaka City and Sizuoka City, Japan Participants: Semi-random sampling of 200 wives in each city. From the Osaka subjects, 100 non-smoking wives were selected for the validity study. Main outcome measures: Kappa coefficient for reliability of self reported smoking status. Correlation coefficients between environmental nicotine concentration, cotinine in saliva and urine, and self reported smoking status. Results: The κ coefficient for the repeated interview was high suggesting sufficient reliability of the response. The proportion of self reported current smokers misclassified as non-smokers was equivalent to the misclassified self reported non-smokers. Ambient concentration of nicotine and personal exposure to nicotine correlated with each other and also with salivary cotinine and self reported ETS exposure but not with urinary cotinine/creatinine ratio (CCR). There was no major difference in diet and lifestyle related to husband's smoking status. Conclusion: Self reported smoking status by Japanese wives shows high reliability. It also shows high validity when verified by both nicotine exposure and salivary cotinine, but not by CCR. A previous report questioning the credibility of self reported smoking status, based on questionable CCR, could thus be of dubious validity. In addition, possible dietary and lifestyle confounding factors associated with smoking husbands were not demonstrable, a finding not reported

  4. The foundations of reusability: Successful experience and important conclusions from planning and scheduling of space operations

    NASA Technical Reports Server (NTRS)

    Hornstein, Rhoda Shaller; Willoughby, J. K.

    1995-01-01

    NASA's Office of Space Communications is sponsoring a combined technical and management initiative to dramatically decrease the cost of preparing for and conducting space operations. The authors present their successful experience and important conclusions from producing generalized and readily reusable solutions and systems for planning and scheduling applications. While generality by itself should enable reuse, generality alone may not produce the desired cost savings. Generality achieved by accumulating numerous special cases within a software system often increases the complexity of the software to the extent that maintenance costs overtake development savings. Because of this phenomenon, the authors have insisted on simplicity, as well as generality, to achieve cost-effective operation reusability. Simplicity and generality can be accomplished simultaneously when the basic 'Building Blocks' for a problem domain, in this paper, planning and scheduling, are discovered and implemented with reuse in mind. The Building Blocks for planning and scheduling are described. The authors also present examples of how these Building Blocks have accommodated various scenarios that were previously treated as mission-peculiar. Two case histories are presented to demonstrate operational reusability and cost effectiveness.

  5. Blast Testing Issues and TBI: Experimental Models That Lead to Wrong Conclusions.

    PubMed

    Needham, Charles E; Ritzel, David; Rule, Gregory T; Wiri, Suthee; Young, Leanne

    2015-01-01

    Over the past several years, we have noticed an increase in the number of blast injury studies published in peer-reviewed biomedical journals that have utilized improperly conceived experiments. Data from these studies will lead to false conclusions and more confusion than advancement in the understanding of blast injury, particularly blast neurotrauma. Computational methods to properly characterize the blast environment have been available for decades. These methods, combined with a basic understanding of blast wave phenomena, enable researchers to extract useful information from well-documented experiments. This basic understanding must include the differences and interrelationships of static pressure, dynamic pressure, reflected pressure, and total or stagnation pressure in transient shockwave flows, how they relate to loading of objects, and how they are properly measured. However, it is critical that the research community effectively overcomes the confusion that has been compounded by a misunderstanding of the differences between the loading produced by a free field explosive blast and loading produced by a conventional shock tube. The principles of blast scaling have been well established for decades and when properly applied will do much to repair these problems. This paper provides guidance regarding proper experimental methods and offers insights into the implications of improperly designed and executed tests. Through application of computational methods, useful data can be extracted from well-documented historical tests, and future work can be conducted in a way to maximize the effectiveness and use of valuable biological test data.

  6. Experimental laser anastomosis of the large bowel: conclusive results and future prospect

    NASA Astrophysics Data System (ADS)

    Kawahara, Masaki; Kuramoto, Shu; Ryan, Peter

    2003-06-01

    Completely sutureless end-to-end large bowel anastomoses were successfully performed in New Zealand white rabbits by using 1064 nm, 0.4-W power pulsating Nd:YAG laser to produce welding. Purpose: The aim of this study was to assess the results of our whole experimental data and summarize our experimental work on laser colon anastomosis. Methods: This experimental study investigated integrity of anastomosis, degree of narrowing, macroscopic appearance, microscopic findings, animal body weight change, and collagen concentration of laser colon anastomoses, compared with those of conventional sutured anastomoses up to ninety postoperative days. Results: Bursting pressures of laser anastomoses were at first low and came to be equivalent at seven days, but the laser group exhibited a consistent narrowing tendency. However, laser anastomoses demonstrated fewer and milder adhesions, and animals showed a better recovery of body weight. Histologically, laser anastomoses showed better layer-to-layer reconstitution without foreign body response and with less fibrosis. Difference in collagen concentration did not reach statistical significance. Conclusion: The technique of laser anastomosis presents a promising alternative to suturing in reconstitution of the large bowel.

  7. Conclusions of the M3D/NIMROD Cross-Code Benchmark

    NASA Astrophysics Data System (ADS)

    Breslau, J.; Park, W.; Jardin, S.; Strauss, H.; Schnack, D.; Pankin, A.

    2004-11-01

    Cross-validation of the nonlinear M3D [1] and NIMROD [2] codes in the resistive MHD regime in tokamaks has been brought to a successful conclusion. The small but well-diagnosed CDX-U device was selected for the benchmark because its low temperature (S < 10^5) is readily handled by the two codes. The test problem consisted of determining the growth rates, eigenfunctions, and nonlinear evolution of resistive internal kink modes from a base equilibrium with q_0≈ 0.92. Good agreement between the codes is observed in all three predictions. However, there is an unexpected lack of agreement between these predictions and experimental observations: whereas the 1,1 sawtooth crash in the device is a repeating phenomenon consistent with the survival of the discharge, both codes predict a spectrum of unstable resistive ballooning modes whose growth rate increases with toroidal mode number n>1, occurring near the plasma boundary and present even when q_0>1. These findings call into question the applicability of the resistive MHD model even to low temperature tokamak plasmas and suggest the need for the addition of two-fluid terms or other new physics to make accurate predictions of their behavior. [1] W. Park, et al., Phys. Plasmas 6, 1796 (1999). [2] C.R. Sovinec, et al., Phys. Plasmas 10, 1727 (2003).

  8. Cumulative Instructional Time and Relative Effectiveness Conclusions: Extending Research on Response Intervals, Learning, and Measurement Scale.

    PubMed

    Black, Michelle P; Skinner, Christopher H; Forbes, Bethany E; McCurdy, Merilee; Coleman, Mari Beth; Davis, Kristie; Gettelfinger, Maripat

    2016-03-01

    Adapted alternating treatments designs were used to evaluate three computer-based flashcard reading interventions (1-s, 3-s, or 5-s response intervals) across two students with disabilities. When learning was plotted with cumulative instructional sessions on the horizontal axis, the session-series graphs suggest that the interventions were similarly effective. When the same data were plotted as a function of cumulative instructional seconds, time-series graphs suggest that the 1-s intervention caused the most rapid learning for one student. Discussion focuses on applied implications of comparative effectiveness studies and why measures of cumulative instructional time are needed to identify the most effective intervention(s).Comparative effectiveness studies may not identify the intervention which causes the most rapid learning.Session-series repeated measures are not the same as time-series repeated measures.Measuring the time students spend in each intervention (i.e., cumulative instructional seconds) allows practitioners to identify interventions that enhance learning most rapidly.Student time spent working under interventions is critical for drawing applied conclusions. PMID:27606240

  9. NIH deltanoids meeting on Vitamin D and cancer. Conclusion and strategic options.

    PubMed

    Bouillon, Roger; Moody, Terry; Sporn, Michael; Barrett, J Carl; Norman, Anthony W

    2005-10-01

    A meeting on "Cancer Chemoprevention and Cancer Treatment; role of vitamin D, 1alpha,25-(OH)(2)D(3) and deltanoids" was held on the NIH Congres, Bethesda in November 2004. The following conclusions were presented at the end of this symposium. Vitamin D deficiency and insufficiency are worldwide problems and are associated with several health problems including higher cancer prevalence. There is convincing evidence that the active vitamin D hormone, 1alpha,25(OH)(2)D(3), can decrease cell proliferation, modify cell apoptosis and control malignant cell growth. Therefore academia, public funding agencies and industry should urgently design appropriate studies to better define the causal relationship between vitamin D nutrition and cancer, define the optimal vitamin D nutrition based on accurate 25(OH)D measurement and inform the public and medical profession accordingly. Selective vitamin D receptor modulators are a potentially interesting new class of chemopreventive and chemotherapeutic agents as demonstrated by several first generation analogs have provided a convincing proof of concept. In the mean time, the public should be informed about the risks of vitamin D deficiency and insufficiency and appropriate steps should be taken to improve the vitamin D nutritional status of large parts of the world population. PMID:16043351

  10. A dual-isotope approach to allow conclusive partitioning between three sources.

    PubMed

    Whitman, Thea; Lehmann, Johannes

    2015-01-01

    Stable isotopes have proved to be a transformative tool; their application to distinguish between two sources in a mixture has been a cornerstone of biogeochemical research. However, quantitatively partitioning systems using two stable isotopes (for example, (13)C and (12)C) has been largely limited to only two sources, and systems of interest often have more than two components, with interactive effects. Here we introduce a dual-isotope approach to allow conclusive partitioning between three sources, using only two stable isotopes. We demonstrate this approach by partitioning soil CO2 emissions derived from microbial mineralization of soil organic carbon (SOC), added pyrogenic organic matter (PyOM) and root respiration. We find that SOC mineralization in the presence of roots is 23% higher (P<0.05) when PyOM is also present. Being able to discern three sources with two isotopes will be of great value not only in biogeochemical research, but may also expand hitherto untapped methodologies in diverse fields. PMID:26530521

  11. A dual-isotope approach to allow conclusive partitioning between three sources

    PubMed Central

    Whitman, Thea; Lehmann, Johannes

    2015-01-01

    Stable isotopes have proved to be a transformative tool; their application to distinguish between two sources in a mixture has been a cornerstone of biogeochemical research. However, quantitatively partitioning systems using two stable isotopes (for example, 13C and 12C) has been largely limited to only two sources, and systems of interest often have more than two components, with interactive effects. Here we introduce a dual-isotope approach to allow conclusive partitioning between three sources, using only two stable isotopes. We demonstrate this approach by partitioning soil CO2 emissions derived from microbial mineralization of soil organic carbon (SOC), added pyrogenic organic matter (PyOM) and root respiration. We find that SOC mineralization in the presence of roots is 23% higher (P<0.05) when PyOM is also present. Being able to discern three sources with two isotopes will be of great value not only in biogeochemical research, but may also expand hitherto untapped methodologies in diverse fields. PMID:26530521

  12. Evaluating Behaviorally Oriented Aviation Maintenance Resource Management (MRM) Training and Programs: Methods, Results, and Conclusions

    NASA Technical Reports Server (NTRS)

    Taylor, James C.; Thomas, Robert L., III

    2003-01-01

    Assessment of the impact of Aviation Resource Management Programs on aviation culture and performance has compelled a considerable body of research (Taylor & Robertson, 1995; Taylor, 1998; Taylor & Patankar, 2001). In recent years new methods have been applied to the problem of maintenance error precipitated by factors such as the need for self-assessment of communication and trust. The present study - 2002 -- is an extension of that past work. This research project was designed as the conclusion of a larger effort to help understand, evaluate and validate the impact of Maintenance Resource Management (MRM) training programs, and other MRM interventions on participant attitudes, opinions, behaviors, and ultimately on enhanced safety performance. It includes research and development of evaluation methodology as well as examination of psychological constructs and correlates of maintainer performance. In particular, during 2002, three issues were addressed. First, the evaluation of two (independent & different) MRM programs for changing behaviors was undertaken. In one case we were able to further apply the approach to measuring written communication developed during 2001 (Taylor, 2002; Taylor & Thomas, 2003). Second, the MRM/TOQ surveys were made available for completion on the internet. The responses from these on-line surveys were automatically linked to a results calculator (like the one developed and described in Taylor, 2002) to aid industry users in analyzing and evaluating their local survey data on the internet. Third, the main trends and themes from our research about MRM programs over the past dozen years were reviewed.

  13. Blast Testing Issues and TBI: Experimental Models That Lead to Wrong Conclusions

    PubMed Central

    Needham, Charles E.; Ritzel, David; Rule, Gregory T.; Wiri, Suthee; Young, Leanne

    2015-01-01

    Over the past several years, we have noticed an increase in the number of blast injury studies published in peer-reviewed biomedical journals that have utilized improperly conceived experiments. Data from these studies will lead to false conclusions and more confusion than advancement in the understanding of blast injury, particularly blast neurotrauma. Computational methods to properly characterize the blast environment have been available for decades. These methods, combined with a basic understanding of blast wave phenomena, enable researchers to extract useful information from well-documented experiments. This basic understanding must include the differences and interrelationships of static pressure, dynamic pressure, reflected pressure, and total or stagnation pressure in transient shockwave flows, how they relate to loading of objects, and how they are properly measured. However, it is critical that the research community effectively overcomes the confusion that has been compounded by a misunderstanding of the differences between the loading produced by a free field explosive blast and loading produced by a conventional shock tube. The principles of blast scaling have been well established for decades and when properly applied will do much to repair these problems. This paper provides guidance regarding proper experimental methods and offers insights into the implications of improperly designed and executed tests. Through application of computational methods, useful data can be extracted from well-documented historical tests, and future work can be conducted in a way to maximize the effectiveness and use of valuable biological test data. PMID:25904891

  14. Working Group Meeting on Heavy Vehicle Aerodynamic Drag: Presentations and Summary of Comments and Conclusions

    SciTech Connect

    Browand, F; Gutierrez, W; Leonard, A; McBride, D; McCallen, R; Ross, J; Roth, K; Rutledge, W; Salari, K

    1998-09-28

    The first Working Group Meeting on Heavy Vehicle Aerodynamic Drag was held at Sandia National Laboratories (SNL) in Albuquerque, New Mexico on August 28, 1998. The purpose of the meeting was to review the proposed Multi-Year Program Plan (MYPP) and provide an update on the Group"s progress. In addition, the technical details of each organization"s activities were presented and discussed. Presentations were given by representatives from the Department of Energy (DOE) Office of Transportation Technology Office of Heavy Vehicle Technology (OHVT), Lawrence Livermore National Laboratory (LLNL), SNL, University of Southern California (USC), California Institute of Technology (Caltech), and NASA Ames Research Center. These presenters are part of a DOE appointed Technical Team assigned to developing the MYPP. The goal of the MYPP is to develop and demonstrate the ability to simulate and analyze aerodynamic flow around heavy truck vehicles using existing and advanced computational tools (A Multi-Year Program Plan for the Aerodynamic Design of Heavy Vehicles, R. McCallen, D. McBride, W. Rutledge, F. Browand, A. Leonard, .I. Ross, UCRL-PROP- 127753 Dr. Rev 2, May 1998). This report contains the technical presentations (viewgraphs) delivered at the Meeting, briefly summarizes the comments and conclusions from the Meeting participants, and outlines the future action items.

  15. How Preferences For Eager Versus Vigilant Judgment Strategies Affect Self-Serving Conclusions

    PubMed Central

    Molden, Daniel C.; Higgins, E. Tory

    2008-01-01

    People are often motivated to reach self-serving conclusions during judgment. This article examines how such self-serving judgment outcomes are influenced by preferences for different judgment strategies. Two studies tested how preferences for eager (promotion-oriented) versus vigilant (prevention-oriented) judgment strategies affected self-serving explanations for success or failure. Regardless of their performance, those preferring vigilant strategies selectively endorsed a few explanations above others, whereas those preferring eager strategies more evenly endorsed multiple explanations. Furthermore, although the explanations selected by those preferring vigilant strategies were indeed self-serving (emphasizing personal responsibility for success and external circumstances for failure), the more balanced endorsement of multiple explanations by those preferring eager strategies was associated with attenuated self-serving tendencies. Finally, those preferring eager strategies were also less self-serving in their generalization from explanations of current performance to predictions of future performance. The larger implications of these findings for the role of strategic preferences in judgment are discussed. PMID:19727421

  16. The virucidal effect of platelet concentrates: preliminary study and first conclusions.

    PubMed

    Maurice, A; Marchand-Arvier, M; Edert, D; Le Faou, A; Gondrexon, G; Vigneron, C

    2002-06-01

    Despite the increased safety of blood components, achieved through improved donor selection and testing, transfusion recipients remain at risk of transfusion-associated diseases. Transfusion of cellular blood components has been implicated in transmission of viral, bacterial and protozoan diseases. Investigators have studied a myriad of processes for pathogen depletion and/or inactivation. No successful treatments, apart the leukodepletion, have already been identified for red cells and platelets. And more, several evidences indicate that platelets play a key role in host defence against infection. High levels of pathogens were added to single-donor platelet concentrates (PC) containing 3 to 5 10(11) platelets in 300 ml. The infectivity of each pathogen was measured with established biologic assays. The following levels of pathogen inactivation were achieved : >10(2.63) plaque-forming units (PFU) per ml of adenovirus 5 (ADV5), >10(5.6) PFU per ml of Poliovirus 1 (P1) and >10(4.1) PFU per ml of vaccinia virus (VaV). In conclusion, the PC show a potential virucidal effect. This inactivation process has been found with bacteria and still remains unknown for viruses.

  17. Results and Conclusions from the NASA Isokinetic Total Water Content Probe 2009 IRT Test

    NASA Technical Reports Server (NTRS)

    Reehorst, Andrew; Brinker, David

    2010-01-01

    The NASA Glenn Research Center has developed and tested a Total Water Content Isokinetic Sampling Probe. Since, by its nature, it is not sensitive to cloud water particle phase nor size, it is particularly attractive to support super-cooled large droplet and high ice water content aircraft icing studies. The instrument comprises the Sampling Probe, Sample Flow Control, and Water Vapor Measurement subsystems. Results and conclusions are presented from probe tests in the NASA Glenn Icing Research Tunnel (IRT) during January and February 2009. The use of reference probe heat and the control of air pressure in the water vapor measurement subsystem are discussed. Several run-time error sources were found to produce identifiable signatures that are presented and discussed. Some of the differences between measured Isokinetic Total Water Content Probe and IRT calibration seems to be caused by tunnel humidification and moisture/ice crystal blow around. Droplet size, airspeed, and liquid water content effects also appear to be present in the IRT calibration. Based upon test results, the authors provide recommendations for future Isokinetic Total Water Content Probe development.

  18. Results and conclusions of pine treeline advanced project in subarctic Finland

    SciTech Connect

    Siren, G.

    1997-12-31

    The original project components dealt with seed germination, soil conditions, competition, seedling ecology in and development. Subsequent research into flowering, seed maturation, dispersal and sexual development gained notable interest, as the uninhibited advance of the pine treeline continued. Since then the significant roles of repeated seed years and stand development became evident as stem numbers first increased and thereafter decreased. Improving bio-energy resources and quantifying the increasing CO{sub 2} sink dominated the sup-projects in the final stages. Ultimately the careful age and dry weight measurements and stem inventories prove decisively important in determining what factors were the main prerequisites for the advance of pine on forest-tundra and the development of the new CO{sub 2} sink. During the 20th century the favorable climate has promoted the advance of pine in the far north of Finland, which would appear to support the IPCC message of global warming. A consequence of this climate warming might be that the productive forest area in northernmost Finland will increase rather dramatically during the next century. Considering the longevity of pine, the standing productive forest stock and CO{sub 2} sink capacity would hence increase accordingly. It would therefore seem prudent to recommend the enhancement of conifer seed years and intensified experimentation with genetically tested conifer species throughout the circumpolar treeline regions. Consequently, through sustainable use of new biomass reserves, new areas south of the timberline could be opened to allow for potential ecological forestry practices and alternate energy sources could be developed. At the same time, this will create new employment opportunities for local people in all circumpolar regions.

  19. Range imaging laser radar

    DOEpatents

    Scott, M.W.

    1990-06-19

    A laser source is operated continuously and modulated periodically (typically sinusoidally). A receiver imposes another periodic modulation on the received optical signal, the modulated signal being detected by an array of detectors of the integrating type. Range to the target determined by measuring the phase shift of the intensity modulation on the received optical beam relative to a reference. The receiver comprises a photoemitter for converting the reflected, periodically modulated, return beam to an accordingly modulated electron stream. The electron stream is modulated by a local demodulation signal source and subsequently converted back to a photon stream by a detector. A charge coupled device (CCD) array then averages and samples the photon stream to provide an electrical signal in accordance with the photon stream. 2 figs.

  20. Range imaging laser radar

    DOEpatents

    Scott, Marion W.

    1990-01-01

    A laser source is operated continuously and modulated periodically (typicy sinusoidally). A receiver imposes another periodic modulation on the received optical signal, the modulated signal being detected by an array of detectors of the integrating type. Range to the target determined by measuring the phase shift of the intensity modulation on the received optical beam relative to a reference. The receiver comprises a photoemitter for converting the reflected, periodically modulated, return beam to an accordingly modulated electron stream. The electron stream is modulated by a local demodulation signal source and subsequently converted back to a photon stream by a detector. A charge coupled device (CCD) array then averages and samples the photon stream to provide an electrical signal in accordance with the photon stream.

  1. Long-range connectomics.

    PubMed

    Jbabdi, Saad; Behrens, Timothy E

    2013-12-01

    Decoding neural algorithms is one of the major goals of neuroscience. It is generally accepted that brain computations rely on the orchestration of neural activity at local scales, as well as across the brain through long-range connections. Understanding the relationship between brain activity and connectivity is therefore a prerequisite to cracking the neural code. In the past few decades, tremendous technological advances have been achieved in connectivity measurement techniques. We now possess a battery of tools to measure brain activity and connections at all available scales. A great source of excitement are the new in vivo tools that allow us to measure structural and functional connections noninvasively. Here, we discuss how these new technologies may contribute to deciphering the neural code.

  2. [Men's health report - Conclusion and challenges for sex- and gender-sensitive health reporting].

    PubMed

    Starker, Anne; Rommel, Alexander; Saß, Anke-Christine

    2016-08-01

    In December 2014, the Federal Health Reporting published the first official report on men's health in Germany. The report covers a wide range of topics, from diseases and causes of death to health-related behaviors and male-specific prevention. Special chapters put the focus on the impact that working life and certain living arrangements may have on health. Based on preliminary methodological work on gender-sensitive health reporting, a step-wise approach was pursued. In addition to mere comparisons between men and women, differences within men were taken into account with respect to certain stressors, risks and resources. Moreover, guided by theory, findings were interpreted and discussed in the context of changing political and societal conditions. In the present article, the project team takes a critical look at its work: What steps towards sex- and gender-sensitive health reporting could be taken? And to what extent does the current approach leave room for improvement? In contributing to a better description of the health of men and women, gender-sensitive health reporting may provide a sound empirical basis for the implementation of gender-appropriate health care.

  3. The sociality–health–fitness nexus: synthesis, conclusions and future directions

    PubMed Central

    Nunn, Charles L.; Craft, Meggan E.; Gillespie, Thomas R.; Schaller, Mark; Kappeler, Peter M.

    2015-01-01

    This theme issue has highlighted the links between sociality, health and fitness in a broad range of organisms, and with approaches that include field and captive studies of animals, comparative and meta-analyses, theoretical modelling and clinical and psychological studies of humans. In this concluding chapter, we synthesize the results of these diverse studies into some of the key concepts discussed in this issue, focusing on risks of infectious disease through social contact, the effects of competition in groups on susceptibility to disease, and the integration of sociality into research on life-history trade-offs. Interestingly, the studies in this issue both support pre-existing hypotheses, and in other ways challenge those hypotheses. We focus on unexpected results, including a lack of association between ectoparasites and fitness and weak results from a meta-analysis of the links between dominance rank and immune function, and place these results in a broader context. We also review relevant topics that were not covered fully in this theme issue, including self-medication and sickness behaviours, society-level defences against infectious disease, sexual selection, evolutionary medicine, implications for conservation biology and selective pressures on parasite traits. We conclude by identifying general open questions to stimulate and guide future research on the links between sociality, health and fitness. PMID:25870401

  4. Conference on abuse liability and appeal of tobacco products: conclusions and recommendations.

    PubMed

    Henningfield, Jack E; Hatsukami, Dorothy K; Zeller, Mitch; Peters, Ellen

    2011-07-01

    The rate of initiation and progression to dependence and premature mortality are higher for tobacco products than for any other dependence producing substance. This is not explained simply by the addictiveness ("abuse liability") or by enticing product designs ("product appeal") alone, but rather by both of these factors in combination with marketing and social influences that also influence "product appeal". A working meeting of leading experts in abuse liability (AL) and product appeal was convened to examine how these disciplines could be more effectively applied to the evaluation of tobacco products for the purposes of regulation that would include setting standards for designs and contents intended to reduce the risk of initiation and dependence. It was concluded that abuse liability assessment (ALA) is a validated approach to testing pharmaceutical products but has not been extensively applied to tobacco products: such application has demonstrated feasibility, but special challenges include the diverse range of products, product complexity, and the absence of satisfactory placebo products. Consumer testing for product appeal is widely used by consumer product marketers as well as by researchers in their efforts to understand consumer product preferences and use but has not been extensively applied to tobacco products except by the tobacco industry. Recommendations for testing, methods development, and research were developed. A major recommendation was that tobacco products should be tested for AL and product appeal, and the results integrated and evaluated so as to more accurately predict risk of initiation, dependence, and persistence of use. PMID:21376479

  5. Conference on abuse liability and appeal of tobacco products: conclusions and recommendations.

    PubMed

    Henningfield, Jack E; Hatsukami, Dorothy K; Zeller, Mitch; Peters, Ellen

    2011-07-01

    The rate of initiation and progression to dependence and premature mortality are higher for tobacco products than for any other dependence producing substance. This is not explained simply by the addictiveness ("abuse liability") or by enticing product designs ("product appeal") alone, but rather by both of these factors in combination with marketing and social influences that also influence "product appeal". A working meeting of leading experts in abuse liability (AL) and product appeal was convened to examine how these disciplines could be more effectively applied to the evaluation of tobacco products for the purposes of regulation that would include setting standards for designs and contents intended to reduce the risk of initiation and dependence. It was concluded that abuse liability assessment (ALA) is a validated approach to testing pharmaceutical products but has not been extensively applied to tobacco products: such application has demonstrated feasibility, but special challenges include the diverse range of products, product complexity, and the absence of satisfactory placebo products. Consumer testing for product appeal is widely used by consumer product marketers as well as by researchers in their efforts to understand consumer product preferences and use but has not been extensively applied to tobacco products except by the tobacco industry. Recommendations for testing, methods development, and research were developed. A major recommendation was that tobacco products should be tested for AL and product appeal, and the results integrated and evaluated so as to more accurately predict risk of initiation, dependence, and persistence of use.

  6. Analysis of the 2002 flood in Austria - facts, conclusions and mitigation measures

    NASA Astrophysics Data System (ADS)

    Formayer, H.; Habersack, H.; Holzmann, H.; Moser, A.; Seibert, P.

    2003-04-01

    In August 2002 Austria was affected - like other European countries e.g. Germany, Czech Republic or Romania - by an extreme flood event, which occurred in Central Europe and brought rainfall of extraordinary extent and flood recurrence intervals from several years to more than 1000 years. Losses of human life and livestock and damages of infrastructure, buildings, public and private properties rose the public awareness and the demand for improvement of future flood mitigation measures. The Centre of Natural Hazards and Risk Management of the BOKU-University for Natural Resources and Applied Life Sciences, Vienna startet as a first initiative with a summary and review of all reports and documents upon the regional impact of the event. The summary includes the description of the meteorological boundary conditions, the flood generation and their frequencies. A broad range of disciplinary aspects like river engineering, river ecology, vegetation and biology, soil science and soil mechanics, rural and urban planning were involved. The inventory and interpretation of the damages forms a base for assessment of shortcomings and requirements for a successful flood protection strategy for the future. The holistic approach will result in improved regional water management plans and assists in the development of a sustainable, catchment based flood mitigation strategy. Besides the review of the event the presentation will comment on some lacks and shortcomings in the collected data base and will give hints for future demands in online monitoring requirements, on establishment and improvement of forecasting tools and of the information transfer to the emergency services.

  7. Conference on Abuse Liability and Appeal of Tobacco Products: Conclusions and Recommendations*

    PubMed Central

    Hatsukami, Dorothy K.; Zeller, Mitch; Peters, Ellen

    2011-01-01

    The rate of initiation and progression to dependence and premature mortality are higher for tobacco products than for any other dependence producing substance. This is not explained simply by the addictiveness (“abuse liability”) or by enticing product designs (“product appeal”) alone, but rather by both of these factors in combination with marketing and social influences that also influence “product appeal”. A working meeting of leading experts in abuse liability (AL) and product appeal was convened to examine how these disciplines could be more effectively applied to the evaluation of tobacco products for the purposes of regulation that would include setting standards for designs and contents intended to reduce the risk of initiation and dependence. It was concluded that abuse liability assessment (ALA) is a validated approach to testing pharmaceutical products but has not been extensively applied to tobacco products: such application has demonstrated feasibility, but special challenges include the diverse range of products, product complexity, and the absence of satisfactory placebo products. Consumer testing for product appeal is widely used by consumer products marketers as well as by researchers in their efforts to understand consumer product preferences and use but has not been extensively applied to tobacco products except by the tobacco industry. Recommendations for testing, methods development, and research were developed. A major recommendation was that tobacco products should be tested for AL and product appeal, and the results integrated and evaluated so as to more accurately predict risk of initiation, dependence, and persistence of use. PMID:21376479

  8. Investigating the Origin of Bright Materials on Vesta: Synthesis, Conclusions, and Implications

    NASA Technical Reports Server (NTRS)

    Li, Jian-Yang; Mittlefehldt, D. W.; Pieters, C. M.; De Sanctis, M. C.; Schroder, S. E.; Hiesinger, H.; Blewett, D. T.; Russell, C. T.; Raymond, C. A.; Keller, H. U.

    2012-01-01

    The Dawn spacecraft started orbiting the second largest asteroid (4) Vesta in August 2011, revealing the details of its surface at an unprecedented pixel scale as small as approx.70 m in Framing Camera (FC) clear and color filter images and approx.180 m in the Visible and Infrared Spectrometer (VIR) data in its first two science orbits, the Survey Orbit and the High Altitude Mapping Orbit (HAMO) [1]. The surface of Vesta displays the greatest diversity in terms of geology and mineralogy of all asteroids studied in detail [2, 3]. While the albedo of Vesta of approx.0.38 in the visible wavelengths [4, 5] is one of the highest among all asteroids, the surface of Vesta shows the largest variation of albedos found on a single asteroid, with geometric albedos ranging at least from approx.0.10 to approx.0.67 in HAMO images [5]. There are many distinctively bright and dark areas observed on Vesta, associated with various geological features and showing remarkably different forms. Here we report our initial attempt to understand the origin of the areas that are distinctively brighter than their surroundings. The dark materials on Vesta clearly are different in origin from bright materials and are reported in a companion paper [6].

  9. [Men's health report - Conclusion and challenges for sex- and gender-sensitive health reporting].

    PubMed

    Starker, Anne; Rommel, Alexander; Saß, Anke-Christine

    2016-08-01

    In December 2014, the Federal Health Reporting published the first official report on men's health in Germany. The report covers a wide range of topics, from diseases and causes of death to health-related behaviors and male-specific prevention. Special chapters put the focus on the impact that working life and certain living arrangements may have on health. Based on preliminary methodological work on gender-sensitive health reporting, a step-wise approach was pursued. In addition to mere comparisons between men and women, differences within men were taken into account with respect to certain stressors, risks and resources. Moreover, guided by theory, findings were interpreted and discussed in the context of changing political and societal conditions. In the present article, the project team takes a critical look at its work: What steps towards sex- and gender-sensitive health reporting could be taken? And to what extent does the current approach leave room for improvement? In contributing to a better description of the health of men and women, gender-sensitive health reporting may provide a sound empirical basis for the implementation of gender-appropriate health care. PMID:27351436

  10. Shuttle payload bay thermal environments: Summary and conclusion report for STS Flights 1-5

    NASA Technical Reports Server (NTRS)

    Fu, J. H.; Graves, G. R.

    1987-01-01

    The thermal data for the payload bay of the first five shuttle flights is summarized and the engineering evaluation of that data is presented. After a general discussion on mission profiles and vehicle configurations, the thermal design and flight instrumentation systems of the payload bay are described. The thermal flight data sources and a categorization of the data are then presented. A thermal flight data summarization section provides temperature data for the five phases of a typical mission profile. These are: prelaunch, ascent, on-orbit, entry and postlanding. The thermal flight data characterization section encompasses this flight data for flight to flight variations, payload effects, temperature ranges, and other variations. Discussion of the thermal environment prediction models in use by industry and various NASA Centers, and the results predicted by these models, is followed by an evaluation of the correlation between the actual flight data and the results predicted by the models. Finally, the available thermal data are evaluated from the viewpoint of the user concerned with establishing the thermal environment in the payload bay. The data deficiencies are discussed and recommendations for their elimination are presented.

  11. Food, plant food, and vegetarian diets in the US dietary guidelines: conclusions of an expert panel.

    PubMed

    Jacobs, David R; Haddad, Ella H; Lanou, Amy Joy; Messina, Mark J

    2009-05-01

    We summarize conclusions drawn from a panel discussion at the "Fifth International Congress on Vegetarian Nutrition" about the roles of and emphasis on food, plant food, and vegetarianism in current and future US dietary guidelines. The most general recommendation of the panel was that future dietary guidelines, following the lead of the 2005 Dietary Guidelines Advisory Committee, should emphasize food-based recommendations and thinking to the full extent that evidence allows. Although nutrient-based thinking and Dietary Reference Intakes (DRIs) may help ensure an adequate diet in the sense that deficiency states are avoided, the emphasis on DRIs may not capture many important nutritional issues and may inhibit a focus on foods. More generally, in the context of the conference on vegetarian nutrition, this report focuses on the history and structure of the Dietary Guidelines Advisory Committee, on various plant food-oriented recommendations that are supported by literature evidence, and on mechanisms for participating in the process of forming dietary guidelines. Among recommendations that likely would improve health and the environment, some are oriented toward increased plant food consumption and some toward vegetarianism. The literature on health effects of individual foods and whole lifestyle diets is insufficient and justifies a call for future food-oriented research, including expanding the evidence base for plant-based and vegetarian diets. The Dietary Guidelines Advisory Committee's role should be carried forward to creation of a publicly accessible icon (eg, the current pyramid) and related materials to ensure that the science base is fully translated for the public.

  12. PACS in the Utrecht University Hospital: final conclusions of the clinical evaluation

    NASA Astrophysics Data System (ADS)

    Wilmink, J. B.; ter Haar Romeny, Bart M.; Barneveld Binkhuysen, Frits H.; Achterberg, A. J.; Zuiderveld, Karel J.; Calkoen, P.; Kouwenberg, Jef M.

    1990-08-01

    In the past three years, a clinical evaluation of a PACS has been performed in the Utrecht University Hospital as part of the Dutch PACS project. The clinical evaluation focussed on the following aspects: technical evaluation of the prototype PACS equipment coupled to the HIS; diagnostic accuracy studies; studies concerning the impact on the organization of the radiology-department and the referring wards; and cost-savings analysis. Some of the results of these subprojects have already been presented at previous SPIE conferences. In this paper the general condusions are presented about the usefulness of the evaluated PAC-System in the daily routine of radiology department and clinic. By making available the images of radiological examinations fast, complete, reliable and continously on the ward, concrete improvements with regard to the current process could be realized. The possibilities of PACS caused an increasing enthousiasm among the clinicians. By the easier access to all images of their patients during 24 hours/day, they saw more images on the day of the examination and images could be more easily used at consultations of other specialists. The overall conclusion is positive, but a lot of work has to be done to transform PACS from an experimental setup into a routine production system on which a flimless hospital can be based. A complete PACS needs an inteffigent Image Management System, which indudes prefetching algorithms based on data from the Hospital Information System and automated procedures for removing obsolete images from the local buffers in the workstations. As yet PACS is very expensive, and the direct savings in the hospital cannot compensate for the high costs of investment. Possibly PACS can contribute to a shorter stay of patients in the hospital. This will lead to savings for government and health insurance companies and they can be expected to contribute to PAS implementation studies.

  13. [Domestic elder abuse and neglect--conclusions from the evaluation of a model project].

    PubMed

    Görgen, T; Nägele, B

    2005-02-01

    The main task of a federally funded model project in the German city of Hannover was to develop approaches for prevention and intervention in the field of domestic elder abuse. Over a three year period (1998-2001), different approaches--like a telephone helpline for senior citizens, and social workers operating as counsellors for elderly people and their relatives--were tested at a local level. The paper presents results from the evaluation of the project and draws conclusions for future prevention and intervention in the field. The authors argue that the explicit use of the conceptual framework of "violence"/"abuse" creates potentials for scandalizing the issue and is therefore supportive for media appearance, whereas it can impede the approach to the main target groups (elderly people and their relatives) and reduce accessibility of counselling services for potential clients. In the light of evaluation results the focus of the project ("domestic elder abuse" or "violence against elderly people in close relationships") was too narrow for a local project. Counselling services were used in a relatively small number of cases; analyses of cases show that incidents of domestic elder abuse are often embedded in complex problem constellations. Cases brought to the attention of the model project were multifaceted and not limited to incidents of neglect and abuse of elderly care recipients caused by caregiver overload. Cases of intimate violence in partnerships and of intergenerational violence without any of the participants being dependent on care show the need to develop a broader concept of domestic elder abuse. Integration of the concepts of domestic violence, violence against women, elder abuse/neglect and abuse/neglect in caregiving relationships is necessary on a conceptual level as well as on the level of interagency cooperation of institutions dealing with cases of "elder abuse". PMID:15756481

  14. [Domestic elder abuse and neglect--conclusions from the evaluation of a model project].

    PubMed

    Görgen, T; Nägele, B

    2005-02-01

    The main task of a federally funded model project in the German city of Hannover was to develop approaches for prevention and intervention in the field of domestic elder abuse. Over a three year period (1998-2001), different approaches--like a telephone helpline for senior citizens, and social workers operating as counsellors for elderly people and their relatives--were tested at a local level. The paper presents results from the evaluation of the project and draws conclusions for future prevention and intervention in the field. The authors argue that the explicit use of the conceptual framework of "violence"/"abuse" creates potentials for scandalizing the issue and is therefore supportive for media appearance, whereas it can impede the approach to the main target groups (elderly people and their relatives) and reduce accessibility of counselling services for potential clients. In the light of evaluation results the focus of the project ("domestic elder abuse" or "violence against elderly people in close relationships") was too narrow for a local project. Counselling services were used in a relatively small number of cases; analyses of cases show that incidents of domestic elder abuse are often embedded in complex problem constellations. Cases brought to the attention of the model project were multifaceted and not limited to incidents of neglect and abuse of elderly care recipients caused by caregiver overload. Cases of intimate violence in partnerships and of intergenerational violence without any of the participants being dependent on care show the need to develop a broader concept of domestic elder abuse. Integration of the concepts of domestic violence, violence against women, elder abuse/neglect and abuse/neglect in caregiving relationships is necessary on a conceptual level as well as on the level of interagency cooperation of institutions dealing with cases of "elder abuse".

  15. Food, plant food, and vegetarian diets in the US dietary guidelines: conclusions of an expert panel.

    PubMed

    Jacobs, David R; Haddad, Ella H; Lanou, Amy Joy; Messina, Mark J

    2009-05-01

    We summarize conclusions drawn from a panel discussion at the "Fifth International Congress on Vegetarian Nutrition" about the roles of and emphasis on food, plant food, and vegetarianism in current and future US dietary guidelines. The most general recommendation of the panel was that future dietary guidelines, following the lead of the 2005 Dietary Guidelines Advisory Committee, should emphasize food-based recommendations and thinking to the full extent that evidence allows. Although nutrient-based thinking and Dietary Reference Intakes (DRIs) may help ensure an adequate diet in the sense that deficiency states are avoided, the emphasis on DRIs may not capture many important nutritional issues and may inhibit a focus on foods. More generally, in the context of the conference on vegetarian nutrition, this report focuses on the history and structure of the Dietary Guidelines Advisory Committee, on various plant food-oriented recommendations that are supported by literature evidence, and on mechanisms for participating in the process of forming dietary guidelines. Among recommendations that likely would improve health and the environment, some are oriented toward increased plant food consumption and some toward vegetarianism. The literature on health effects of individual foods and whole lifestyle diets is insufficient and justifies a call for future food-oriented research, including expanding the evidence base for plant-based and vegetarian diets. The Dietary Guidelines Advisory Committee's role should be carried forward to creation of a publicly accessible icon (eg, the current pyramid) and related materials to ensure that the science base is fully translated for the public. PMID:19297463

  16. On the challenges of drawing conclusions from p-values just below 0.05

    PubMed Central

    2015-01-01

    In recent years, researchers have attempted to provide an indication of the prevalence of inflated Type 1 error rates by analyzing the distribution of p-values in the published literature. De Winter & Dodou (2015) analyzed the distribution (and its change over time) of a large number of p-values automatically extracted from abstracts in the scientific literature. They concluded there is a ‘surge of p-values between 0.041–0.049 in recent decades’ which ‘suggests (but does not prove) questionable research practices have increased over the past 25 years.’ I show the changes in the ratio of fractions of p-values between 0.041–0.049 over the years are better explained by assuming the average power has decreased over time. Furthermore, I propose that their observation that p-values just below 0.05 increase more strongly than p-values above 0.05 can be explained by an increase in publication bias (or the file drawer effect) over the years (cf. Fanelli, 2012; Pautasso, 2010, which has led to a relative decrease of ‘marginally significant’ p-values in abstracts in the literature (instead of an increase in p-values just below 0.05). I explain why researchers analyzing large numbers of p-values need to relate their assumptions to a model of p-value distributions that takes into account the average power of the performed studies, the ratio of true positives to false positives in the literature, the effects of publication bias, and the Type 1 error rate (and possible mechanisms through which it has inflated). Finally, I discuss why publication bias and underpowered studies might be a bigger problem for science than inflated Type 1 error rates, and explain the challenges when attempting to draw conclusions about inflated Type 1 error rates from a large heterogeneous set of p-values. PMID:26246976

  17. Curcumin and aging

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Curcumin has been used commonly as a spice, food additive, and an herbal medicine worldwide. Known as a bioactive polyphenolic, curcumin has a broad range of beneficial properties to human health. Recently, active research on curcumin with respect to aging and related traits in model organisms has d...

  18. Is extinction age dependent?

    USGS Publications Warehouse

    Doran, N.A.; Arnold, A.J.; Parker, W.C.; Huffer, F.W.

    2006-01-01

    Age-dependent extinction is an observation with important biological implications. Van Valen's Red Queen hypothesis triggered three decades of research testing its primary implication: that age is independent of extinction. In contrast to this, later studies with species-level data have indicated the possible presence of age dependence. Since the formulation of the Red Queen hypothesis, more powerful tests of survivorship models have been developed. This is the first report of the application of the Cox Proportional Hazards model to paleontological data. Planktonic foraminiferal morphospecies allow the taxonomic and precise stratigraphic resolution necessary for the Cox model. As a whole, planktonic foraminiferal morphospecies clearly show age-dependent extinction. In particular, the effect is attributable to the presence of shorter-ranged species (range < 4 myr) following extinction events. These shorter-ranged species also possess tests with unique morphological architecture. The morphological differences are probably epiphenomena of underlying developmental and heterochronic processes of shorter-ranged species that survived various extinction events. Extinction survivors carry developmental and morphological characteristics into postextinction recovery times, and this sets them apart from species populations established independently of extinction events. Copyright ?? 2006, SEPM (Society for Sedimentary Geology).

  19. Effects of Non-Differential Exposure Misclassification on False Conclusions in Hypothesis-Generating Studies

    PubMed Central

    Burstyn, Igor; Yang, Yunwen; Schnatter, A. Robert

    2014-01-01

    Despite the theoretical success of obviating the need for hypothesis-generating studies, they live on in epidemiological practice. Cole asserted that “… there is boundless number of hypotheses that could be generated, nearly all of them wrong” and urged us to focus on evaluating “credibility of hypothesis”. Adopting a Bayesian approach, we put this elegant logic into quantitative terms at the study planning stage for studies where the prior belief in the null hypothesis is high (i.e., “hypothesis-generating” studies). We consider not only type I and II errors (as is customary) but also the probabilities of false positive and negative results, taking into account typical imperfections in the data. We concentrate on a common source of imperfection in the data: non-differential misclassification of binary exposure classifier. In context of an unmatched case-control study, we demonstrate—both theoretically and via simulations—that although non-differential exposure misclassification is expected to attenuate real effect estimates, leading to the loss of ability to detect true effects, there is also a concurrent increase in false positives. Unfortunately, most investigators interpret their findings from such work as being biased towards the null rather than considering that they are no less likely to be false signals. The likelihood of false positives dwarfed the false negative rate under a wide range of studied settings. We suggest that instead of investing energy into understanding credibility of dubious hypotheses, applied disciplines such as epidemiology, should instead focus attention on understanding consequences of pursuing specific hypotheses, while accounting for the probability that the observed “statistically significant” association may be qualitatively spurious. PMID:25337942

  20. Glenohumeral Joint Range of Motion in Elite Male Golfers: A Pilot Study

    PubMed Central

    Meria, Erik; Nee, Bob; Davidson, Greg

    2008-01-01

    Background Shoulder injuries account for up to 17% of all golf related musculoskeletal injuries. One cause may be the repetitive stresses applied to the lead shoulder during the backswing and follow-through phases, which may contribute to the frequency of these injuries. The “elite” golfer may be pre-disposed to developing a shoulder injury based upon the reported adaptations to the glenohumeral joint. Objective To examine and compare bilateral glenohumeral joint rotational range of motion in elite golfers using standard goniometric procedures. Methods Twenty-four “elite” male golfers were recruited for this study. Glenohumeral internal (IR) and external rotation (ER) passive range of motion was measured bilaterally at 90° of abduction using a standard universal goniometer. Paired t-tests were utilized to statistically compare the rotational range of motion patterns between the lead and the trailing shoulder. Results No statistical differences existed between each shoulder for mean IR or mean ER measures. This finding was consistent throughout different age groups. External rotation measurements were greater than IR measurements in both extremities. Discussion and Conclusion Unlike other sports requiring repetitive shoulder function, the “elite” golfers sampled in this pilot investigation did not demonstrate a unique passive range of motion pattern between the lead and trailing shoulders. Factors, including subjects' age, may have confounded the findings. Further studies are warranted utilizing cohorts of golfers with matching age and skill levels. Additional shoulder range of motion measures should be evaluated. PMID:21509130

  1. Longitudinal Examination of Age-Predicted Symptom-Limited Exercise Maximum Heart Rate

    PubMed Central

    Zhu, Na; Suarez, Jose; Sidney, Steve; Sternfeld, Barbara; Schreiner, Pamela J.; Carnethon, Mercedes R.; Lewis, Cora E.; Crow, Richard S.; Bouchard, Claude; Haskell, William; Jacobs, David R.

    2010-01-01

    Purpose To estimate the association of age with maximal heart rate (MHR). Methods Data were obtained in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Participants were black and white men and women aged 18-30 in 1985-86 (year 0). A symptom-limited maximal graded exercise test was completed at years 0, 7, and 20 by 4969, 2583, and 2870 participants, respectively. After exclusion 9622 eligible tests remained. Results In all 9622 tests, estimated MHR (eMHR, beats/minute) had a quadratic relation to age in the age range 18 to 50 years, eMHR=179+0.29*age-0.011*age2. The age-MHR association was approximately linear in the restricted age ranges of consecutive tests. In 2215 people who completed both year 0 and 7 tests (age range 18 to 37), eMHR=189–0.35*age; and in 1574 people who completed both year 7 and 20 tests (age range 25 to 50), eMHR=199–0.63*age. In the lowest baseline BMI quartile, the rate of decline was 0.20 beats/minute/year between years 0-7 and 0.51 beats/minute/year between years 7-20; while in the highest baseline BMI quartile there was a linear rate of decline of approximately 0.7 beats/minute/year over the full age of 18 to 50 years. Conclusion Clinicians making exercise prescriptions should be aware that the loss of symptom-limited MHR is much slower at young adulthood and more pronounced in later adulthood. In particular, MHR loss is very slow in those with lowest BMI below age 40. PMID:20639723

  2. Immunological Aging

    EPA Science Inventory

    Immunosenescence is associated with an increased incidence and severity of infections with common pathogens, neoplastic disease and autoimmunity. In general, aging is associated with a decline in function at the cellular level, rather than cell loss, although thymic atrophy and ...

  3. Epigenetics and aging

    PubMed Central

    Pal, Sangita; Tyler, Jessica K.

    2016-01-01

    Over the past decade, a growing number of studies have revealed that progressive changes to epigenetic information accompany aging in both dividing and nondividing cells. Functional studies in model organisms and humans indicate that epigenetic changes have a huge influence on the aging process. These epigenetic changes occur at various levels, including reduced bulk levels of the core histones, altered patterns of histone posttranslational modifications and DNA methylation, replacement of canonical histones with histone variants, and altered noncoding RNA expression, during both organismal aging and replicative senescence. The end result of epigenetic changes during aging is altered local accessibility to the genetic material, leading to aberrant gene expression, reactivation of transposable elements, and genomic instability. Strikingly, certain types of epigenetic information can function in a transgenerational manner to influence the life span of the offspring. Several important conclusions emerge from these studies: rather than being genetically predetermined, our life span is largely epigenetically determined; diet and other environmental influences can influence our life span by changing the epigenetic information; and inhibitors of epigenetic enzymes can influence life span of model organisms. These new findings provide better understanding of the mechanisms involved in aging. Given the reversible nature of epigenetic information, these studies highlight exciting avenues for therapeutic intervention in aging and age-associated diseases, including cancer. PMID:27482540

  4. Epigenetics and aging.

    PubMed

    Pal, Sangita; Tyler, Jessica K

    2016-07-01

    Over the past decade, a growing number of studies have revealed that progressive changes to epigenetic information accompany aging in both dividing and nondividing cells. Functional studies in model organisms and humans indicate that epigenetic changes have a huge influence on the aging process. These epigenetic changes occur at various levels, including reduced bulk levels of the core histones, altered patterns of histone posttranslational modifications and DNA methylation, replacement of canonical histones with histone variants, and altered noncoding RNA expression, during both organismal aging and replicative senescence. The end result of epigenetic changes during aging is altered local accessibility to the genetic material, leading to aberrant gene expression, reactivation of transposable elements, and genomic instability. Strikingly, certain types of epigenetic information can function in a transgenerational manner to influence the life span of the offspring. Several important conclusions emerge from these studies: rather than being genetically predetermined, our life span is largely epigenetically determined; diet and other environmental influences can influence our life span by changing the epigenetic information; and inhibitors of epigenetic enzymes can influence life span of model organisms. These new findings provide better understanding of the mechanisms involved in aging. Given the reversible nature of epigenetic information, these studies highlight exciting avenues for therapeutic intervention in aging and age-associated diseases, including cancer. PMID:27482540

  5. Neutron range spectrometer

    DOEpatents

    Manglos, Stephen H.

    1989-06-06

    A neutron range spectrometer and method for determining the neutron energy spectrum of a neutron emitting source are disclosed. Neutrons from the source are collimnated along a collimation axis and a position sensitive neutron counter is disposed in the path of the collimated neutron beam. The counter determines positions along the collimation axis of interactions between the neutrons in the neutron beam and a neutron-absorbing material in the counter. From the interaction positions, a computer analyzes the data and determines the neutron energy spectrum of the neutron beam. The counter is preferably shielded and a suitable neutron-absorbing material is He-3. The computer solves the following equation in the analysis: ##EQU1## where: N(x).DELTA.x=the number of neutron interactions measured between a position x and x+.DELTA.x, A.sub.i (E.sub.i).DELTA.E.sub.i =the number of incident neutrons with energy between E.sub.i and E.sub.i +.DELTA.E.sub.i, and C=C(E.sub.i)=N .sigma.(E.sub.i) where N=the number density of absorbing atoms in the position sensitive counter means and .sigma. (E.sub.i)=the average cross section of the absorbing interaction between E.sub.i and E.sub.i +.DELTA.E.sub.i.

  6. Controls on Nitrogen Fluxes from Agricultural Fields: Differing Conclusions Based on Choice of Sensitivity Analysis Method

    NASA Astrophysics Data System (ADS)

    Ahrens, T.; Matson, P.; Lobell, D.

    2006-12-01

    Sensitivity analyses (SA) of biogeochemical and agricultural models are often used to identify the importance of input variables for variance in model outputs, such as crop yield or nitrate leaching. Identification of these factors can aid in prioritizing efforts in research or decision support. Many types of sensitivity analyses are available, ranging from simple One-At-A-Time (OAT) screening exercises to more complex local and global variance-based methods (see Saltelli et al 2004). The purpose of this study was to determine the influence of the type of SA on factor prioritization in the Yaqui Valley, Mexico using the Water and Nitrogen Management Model (WNMM; Chen et al 2005). WNMM, a coupled plant-growth - biogeochemistry simulation model, was calibrated to reproduce crop growth, soil moisture, and gaseous N emission dynamics in experimental plots of irrigated wheat in the Yaqui Valley, Mexico from 1994-1997. Three types of SA were carried out using 16 input variables, including parameters related to weather, soil properties and crop management. Methods used for SA were local OAT, Monte Carlo (MC), and a global variance-based method (orthogonal input; OI). Results of the SA were based on typical interpretations used for each test: maximum absolute ratio of variation (MAROV) for OAT analyses; first- and second-order regressions for MC analyses; and a total effects index for OI. The three most important factors identified by MC and OI methods were generally in agreement, although the order of importance was not always consistent and there was little agreement for variables of less importance. OAT over-estimated the importance of two factors (planting date and pH) for many outputs. The biggest differences between the OAT results and those from MC and OI were likely due to the inability of OAT methods to account for non-linearity (eg. pH and ammonia volatilization), interactions among variables (eg. pH and timing of fertilization) and an over-reliance on baseline

  7. The Battle between the Biometricians and the Mendelians: How Sir Francis Galton's Work Caused His Disciples to Reach Conflicting Conclusions about the Hereditary Mechanism

    ERIC Educational Resources Information Center

    Gillham, Nicholas W.

    2015-01-01

    Francis Galton, Charles Darwin's cousin, had wide and varied interests. They ranged from exploration and travel writing to fingerprinting and the weather. After reading Darwin's "On the Origin of Species," Galton reached the conclusion that it should be possible to improve the human stock through selective breeding, as was the…

  8. Metacognition-augmented cognitive remediation training reduces jumping to conclusions and overconfidence but not neurocognitive deficits in psychosis

    PubMed Central

    Moritz, Steffen; Thoering, Teresa; Kühn, Simone; Willenborg, Bastian; Westermann, Stefan; Nagel, Matthias

    2015-01-01

    The majority of patients with schizophrenia display neurocognitive deficits (e.g., memory impairment) as well as inflated cognitive biases (e.g., jumping to conclusions). Both cognitive domains are implicated in the pathogenesis of the disorder and are known to compromise functional outcome. At present, there is a dearth of effective treatment options. A total of 90 patients with schizophrenia were recruited online (a diagnosis of schizophrenia had been confirmed in a large subgroup during a previous hospital admission). Subsequent to a baseline assessment encompassing psychopathology, self-reported cognition as well as objective memory and reasoning tests, patients were randomized to one of three conditions: standard cognitive remediation (mybraintraining), metacognition-augmented cognition remediation (CR) condition (variant of mybraintraining which encouraged patients to reduce speed of decision-making and attenuate response confidence when participants made high-confidence judgements and hasty incorrect decisions) and a waitlist control group. Patients were retested after 6 weeks and again 3 months after the second assessment. Groups did not differ on psychopathology and neurocognitive parameters at any timepoint. However, at follow-up the metacognitive-augmented CR group displayed a significant reduction on jumping to conclusions and overconfidence. Treatment adherence correlated with a reduction of depression; gains in the training exercises from the standard mybraintraining condition were correlated with improved objective memory performance. The study suggests that metacognition-augmented CR may ameliorate cognitive biases but not neurocognition. The study ties in well with prior research showing that neurocognitive dysfunctions are rather resistant to change; the failure to detect significant improvement of CR or metacognition-augmented CR on psychopathology and neurocognition over time may partly be attributed to a number of methodological limitations of

  9. Metacognition-augmented cognitive remediation training reduces jumping to conclusions and overconfidence but not neurocognitive deficits in psychosis.

    PubMed

    Moritz, Steffen; Thoering, Teresa; Kühn, Simone; Willenborg, Bastian; Westermann, Stefan; Nagel, Matthias

    2015-01-01

    The majority of patients with schizophrenia display neurocognitive deficits (e.g., memory impairment) as well as inflated cognitive biases (e.g., jumping to conclusions). Both cognitive domains are implicated in the pathogenesis of the disorder and are known to compromise functional outcome. At present, there is a dearth of effective treatment options. A total of 90 patients with schizophrenia were recruited online (a diagnosis of schizophrenia had been confirmed in a large subgroup during a previous hospital admission). Subsequent to a baseline assessment encompassing psychopathology, self-reported cognition as well as objective memory and reasoning tests, patients were randomized to one of three conditions: standard cognitive remediation (mybraintraining), metacognition-augmented cognition remediation (CR) condition (variant of mybraintraining which encouraged patients to reduce speed of decision-making and attenuate response confidence when participants made high-confidence judgements and hasty incorrect decisions) and a waitlist control group. Patients were retested after 6 weeks and again 3 months after the second assessment. Groups did not differ on psychopathology and neurocognitive parameters at any timepoint. However, at follow-up the metacognitive-augmented CR group displayed a significant reduction on jumping to conclusions and overconfidence. Treatment adherence correlated with a reduction of depression; gains in the training exercises from the standard mybraintraining condition were correlated with improved objective memory performance. The study suggests that metacognition-augmented CR may ameliorate cognitive biases but not neurocognition. The study ties in well with prior research showing that neurocognitive dysfunctions are rather resistant to change; the failure to detect significant improvement of CR or metacognition-augmented CR on psychopathology and neurocognition over time may partly be attributed to a number of methodological limitations of

  10. Overview of physics results from the conclusive operation of the National Spherical Torus Experiment

    NASA Astrophysics Data System (ADS)

    Sabbagh, S. A.; Ahn, J.-W.; Allain, J.; Andre, R.; Balbaky, A.; Bastasz, R.; Battaglia, D.; Bell, M.; Bell, R.; Beiersdorfer, P.; Belova, E.; Berkery, J.; Betti, R.; Bialek, J.; Bigelow, T.; Bitter, M.; Boedo, J.; Bonoli, P.; Boozer, A.; Bortolon, A.; Boyle, D.; Brennan, D.; Breslau, J.; Buttery, R.; Canik, J.; Caravelli, G.; Chang, C.; Crocker, N.; Darrow, D.; Davis, B.; Delgado-Aparicio, L.; Diallo, A.; Ding, S.; D'Ippolito, D.; Domier, C.; Dorland, W.; Ethier, S.; Evans, T.; Ferron, J.; Finkenthal, M.; Foley, J.; Fonck, R.; Frazin, R.; Fredrickson, E.; Fu, G.; Gates, D.; Gerhardt, S.; Glasser, A.; Gorelenkov, N.; Gray, T.; Guo, Y.; Guttenfelder, W.; Hahm, T.; Harvey, R.; Hassanein, A.; Heidbrink, W.; Hill, K.; Hirooka, Y.; Hooper, E. B.; Hosea, J.; Humphreys, D.; Indireshkumar, K.; Jaeger, F.; Jarboe, T.; Jardin, S.; Jaworski, M.; Kaita, R.; Kallman, J.; Katsuro-Hopkins, O.; Kaye, S.; Kessel, C.; Kim, J.; Kolemen, E.; Kramer, G.; Krasheninnikov, S.; Kubota, S.; Kugel, H.; La Haye, R. J.; Lao, L.; LeBlanc, B.; Lee, W.; Lee, K.; Leuer, J.; Levinton, F.; Liang, Y.; Liu, D.; Lore, J.; Luhmann, N., Jr.; Maingi, R.; Majeski, R.; Manickam, J.; Mansfield, D.; Maqueda, R.; Mazzucato, E.; McLean, A.; McCune, D.; McGeehan, B.; McKee, G.; Medley, S.; Meier, E.; Menard, J.; Menon, M.; Meyer, H.; Mikkelsen, D.; Miloshevsky, G.; Mueller, D.; Munsat, T.; Myra, J.; Nelson, B.; Nishino, N.; Nygren, R.; Ono, M.; Osborne, T.; Park, H.; Park, J.; Park, Y. S.; Paul, S.; Peebles, W.; Penaflor, B.; Perkins, R. J.; Phillips, C.; Pigarov, A.; Podesta, M.; Preinhaelter, J.; Raman, R.; Ren, Y.; Rewoldt, G.; Rognlien, T.; Ross, P.; Rowley, C.; Ruskov, E.; Russell, D.; Ruzic, D.; Ryan, P.; Schaffer, M.; Schuster, E.; Scotti, F.; Shaing, K.; Shevchenko, V.; Shinohara, K.; Sizyuk, V.; Skinner, C. H.; Smirnov, A.; Smith, D.; Snyder, P.; Solomon, W.; Sontag, A.; Soukhanovskii, V.; Stoltzfus-Dueck, T.; Stotler, D.; Stratton, B.; Stutman, D.; Takahashi, H.; Takase, Y.; Tamura, N.; Tang, X.; Taylor, G.; Taylor, C.; Tritz, K.; Tsarouhas, D.; Umansky, M.; Urban, J.; Untergberg, E.; Walker, M.; Wampler, W.; Wang, W.; Whaley, J.; White, R.; Wilgen, J.; Wilson, R.; Wong, K. L.; Wright, J.; Xia, Z.; Youchison, D.; Yu, G.; Yuh, H.; Zakharov, L.; Zemlyanov, D.; Zimmer, G.; Zweben, S. J.

    2013-10-01

    instability seen at intermediate βN is consistent with decreased kinetic RWM stabilization. A model-based RWM state-space controller produced long-pulse discharges exceeding βN = 6.4 and βN/li = 13. Precursor analysis shows 96.3% of disruptions can be predicted with 10 ms warning and a false positive rate of only 2.8%. Disruption halo currents rotate toroidally and can have significant toroidal asymmetry. Global kinks cause measured fast ion redistribution, with full-orbit calculations showing redistribution from the core outward and towards V∥/V = 1 where destabilizing compressional Alfvén eigenmode resonances are expected. Applied 3D fields altered global Alfvén eigenmode characteristics. High-harmonic fast-wave (HHFW) power couples to field lines across the entire width of the scrape-off layer, showing the importance of the inclusion of this phenomenon in designing future RF systems. The snowflake divertor configuration enhanced by radiative detachment showed large reductions in both steady-state and ELM heat fluxes (ELMing peak values down from 19 MW m-2 to less than 1.5 MW m-2). Toroidal asymmetry of heat deposition was observed during ELMs or by 3D fields. The heating power required for accessing H-mode decreased by 30% as the triangularity was decreased by moving the X-point to larger radius, consistent with calculations of the dependence of E × B shear in the edge region on ion heat flux and X-point radius. Co-axial helicity injection reduced the inductive start-up flux, with plasmas ramped to 1 MA requiring 35% less inductive flux. Non-inductive current fraction (NICF) up to 65% is reached experimentally with neutral beam injection at plasma current Ip = 0.7 MA and between 70-100% with HHFW application at Ip = 0.3 MA. NSTX-U scenario development calculations project 100% NICF for a large range of 0.6 < Ip(MA) < 1.35.

  11. SUMMARY CONCLUSIONS FOR THE PILOT IN-SITU CHROMIUM REDUCTION TEST AT RIVERBANK ARMY AMMUNITIONS PLANT

    SciTech Connect

    Ridley, M

    2007-04-25

    for Site 17, and future recommendations for the application of sodium dithionite at additional sites. At the completion of the treatability test, none of the wells at Site 17 had detectable hexavalent chromium, but the sulfate, iron, and manganese concentrations were detected and exceeded the CA secondary drinking water standards. The extraction done after the injection of the sodium dithionite solution to remove the sulfate, manganese, and iron has to a large extent negated the effectiveness of the iron reduction. Riverbank's local groundwater is naturally high in dissolved oxygen (concentration range at Site 17: 1.8 to 6.0 mg/l) and moving this type of groundwater through the reduced zone caused oxidation of the Fe2+ within the treatment zone, followed by a new release of hexavalent chromium detected in one of the treatment wells. Additional extraction at Site 17 will continue to degrade the PRB, threatening to release additional Cr{sup 6+} into the groundwater. Sulfate and manganese only exceed the CA secondary drinking water standards in the area immediately surrounding the PRB. It is unlikely that these contaminants will threaten any water supply wells in the area. The chromium concentrations are increasing in IW-17. The current concentration is still only a third of the original concentration. It might be worth investigating some of the new zero valent iron treatments, such as nanoscale zero-valent iron (NZVI) to replace the in-situ naturally occurring iron, which may no longer be available for reduction. The NZVI has been successfully tested at NASA in Florida (O'Hara, 2006), and demonstrated no release of metals from the natural sediments. This might also be a viable option for other sites at RBAAP.

  12. Testing strategies to establish the safety of nanomaterials: conclusions of an ECETOC workshop.

    PubMed

    Warheit, David B; Borm, Paul J A; Hennes, Christa; Lademann, Jürgen

    2007-06-01

    The European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) convened a workshop in Barcelona, Spain, in November 2005 to develop testing strategies to establish the safety of nanomaterials. It brought together about 70 scientific and clinical experts from industry, academia, government agencies, research institutes, and nongovernmental organizations. The primary questions to be addressed were the following: What can we do today, and what do we need tomorrow? The three major themes of the workshop were: (1) the need for enhanced efforts in nanomaterial characterization; (2) methodologies for assessments of airborne and internal exposures to nanomaterials; and (3) evaluation of the hazard potential--primarily focusing on pulmonary or dermal routes of exposures. Some of the summary conclusions of the workshop included the following: For the development of nanoparticle characterization, the working definition of nanoparticles was defined as < 100 nm in one dimension or < 1000 nm to include aggregates and agglomerates. Moreover, it was concluded that although many physical factors can influence toxicity, including nanoparticle composition, it is dissolution, surface area and characteristics, size, size distribution, and shape that largely determine the functional, toxicological and environmental impact of nanomaterials. In addition, most of the information on potential systemic effects has thus far been derived from combustion-generated particles. With respect to the assessment of external exposures and metrics appropriate for nanoparticles, the general view of the meeting was that currently it is not possible or desirable to select one form of dose metric (i.e., mass, surface area, or particle number) as the most appropriate measure source. However, it was clear that the surface area metric was likely to be of interest and requires further development. In addition, there is a clear and immediate need to develop instruments which are smaller, more

  13. Age Rules

    NASA Astrophysics Data System (ADS)

    Taylor, G. J.

    2015-10-01

    The ages of rocks from the lunar highlands vary widely, even for a single rock sample. This makes it difficult to quantitatively test ideas for early lunar differentiation and formation of the crust. Lars Borg and Amy Gaffney (Lawrence Livermore National Laboratory), and Charles Shearer (University of New Mexico) have devised a set of guidelines to apply to geochronological data that leads to a relative ranking of the reliability of the age determined for a sample. Applying their guidelines to existing data for lunar highland rocks shows an upper limit on rock ages between 4340 and 4370 million years. This is essentially the same as the so-called model ages of the formation of KREEP (a chemical component enriched in potassium, rare earth elements, and phosphorous) and of the formation of the deep source regions that melted to produce mare basalts. The numerous ages close to 4370 million years suggests a complicated and protracted cooling of the primordial lunar magma ocean or a widespread vigorous period of magmatic activity in the Moon.

  14. Seasonal Variation in Daily Temperature Ranges.

    NASA Astrophysics Data System (ADS)

    Ruschy, David L.; Baker, Donald G.; Skaggs, Richard H.

    1991-12-01

    Abrupt spring and autumnal changes in the daily temperature range, from low winter values to higher nonwinter values, were noted in the Minneapolis-St. Paul temperature record. Since this feature was even more evident in five rural and small town Minnesota stations, it can be accepted as real.The inverse relationship found between surface albedo and the daily temperature range indicated that the reduced winter temperature range is associated with snow cover. A second factor controlling the temperature range is cloud cover. This led to the conclusion that variation in net solar radiation is the primary factor.A strong statistical relationship between daily temperature range and the three variables considered (solar radiation, albedo, and cloud cover) was limited to the spring and fall. In March-April the statistically significant factors were solar radiation and albedo, while in October-November they were solar radiation and cloud cover. For the October-December period albedo was also statistically important.

  15. Age estimation of indian adults from orthopantomographs.

    PubMed

    Saxena, Sudhanshu

    2011-01-01

    The aim of this study was to develop a method for estimating the chronological age of Indian adults based on the relationship between age and various morphological variables of canine teeth, obtained using orthopantomographs. Orthopantomographs of 120 selected patients were digitized, and radiographic images of the right maxillary canine in each case were processed using a computer aided drafting program. Pulp/tooth area ratio, pulp/root length ratio, pulp/tooth length ratio, pulp/root width ratio at the cemento-enamel junction level, pulp/root width ratio at midroot level, and pulp/root width ratio at the midpoint between the cemento-enamel junction and the midroot of the canine were calculated by measuring various features on the images. Pearson's correlation, multiple linear regression, one way analysis of variance (ANOVA), and Student's t-test were used for statistical analysis. Regression equations were developed to estimate age from morphological variables. The observed minus the estimated age in the total study sample ranged from -2.2 to +1.5 years, in males from -0.9 to +0.8 years, while in females it was from -1 to +0.8 years. Differences between observed and estimated ages of subjects were not statistically significant. In conclusion there is a linear relationship of pulp/root width ratio at mid-root level and pulp/tooth area ratio of the right maxillary canine with chronological age in the Indian population. Age of subjects can therefore be estimated with a good degree of accuracy using regression equations. PMID:21503416

  16. Martian ages

    NASA Technical Reports Server (NTRS)

    Neukum, G.; Hiller, K.

    1981-01-01

    Four discussions are conducted: (1) the methodology of relative age determination by impact crater statistics, (2) a comparison of proposed Martian impact chronologies for the determination of absolute ages from crater frequencies, (3) a report on work dating Martian volcanoes and erosional features by impact crater statistics, and (4) an attempt to understand the main features of Martian history through a synthesis of crater frequency data. Two cratering chronology models are presented and used for inference of absolute ages from crater frequency data, and it is shown that the interpretation of all data available and tractable by the methodology presented leads to a global Martian geological history that is characterized by two epochs of activity. It is concluded that Mars is an ancient planet with respect to its surface features.

  17. Martian ages

    NASA Astrophysics Data System (ADS)

    Neukum, G.; Hiller, K.

    1981-04-01

    Four discussions are conducted: (1) the methodology of relative age determination by impact crater statistics, (2) a comparison of proposed Martian impact chronologies for the determination of absolute ages from crater frequencies, (3) a report on work dating Martian volcanoes and erosional features by impact crater statistics, and (4) an attempt to understand the main features of Martian history through a synthesis of crater frequency data. Two cratering chronology models are presented and used for inference of absolute ages from crater frequency data, and it is shown that the interpretation of all data available and tractable by the methodology presented leads to a global Martian geological history that is characterized by two epochs of activity. It is concluded that Mars is an ancient planet with respect to its surface features.

  18. Plutonium aging

    SciTech Connect

    Olivas, J.D.

    1999-03-01

    The author describes the plutonium aging program at the Los Alamos National Laboratory. The aging of plutonium components in the US nuclear weapons stockpile has become a concern due to several events: the end of the cold war, the cessation of full scale underground nuclear testing as a result of the Comprehensive Test Ban Treaty (CTBT) and the closure of the Rocky Flats Plant--the site where the plutonium components were manufactured. As a result, service lifetimes for nuclear weapons have been lengthened. Dr. Olivas will present a brief primer on the metallurgy of plutonium, and will then describe the technical approach to ascertaining the long-term changes that may be attributable to self-radiation damage. Facilities and experimental techniques which are in use to study aging will be described. Some preliminary results will also be presented.

  19. Aging Secret

    ERIC Educational Resources Information Center

    Journal of College Science Teaching, 2005

    2005-01-01

    The canny world of advertising has caught on to the free radical theory of aging, marketing a whole array of antioxidants for preventing anything from wrinkles to dry hair to reducing the risk of heart disease--promising to help slow the hands of time. Working with genetically engineered mice--to produce a natural antioxidant enzyme called…

  20. Gay Aging

    ERIC Educational Resources Information Center

    Haber, David

    2009-01-01

    The oldest of the baby boomers (boomers) were age 63 in 2009 and on the verge of retirement. This cohort has had a history of making societal changes throughout its life cycle, and it is unlikely that retirement, as we know it, will remain unscathed. This article highlights two events--the Stonewall Inn riots and two prominent professional…

  1. Aging Kidney Transplantation.

    PubMed

    Musso, Carlos G; Giordani, María C; Imperiali, Nora

    2016-01-01

    There are several immunological and non-immunological factors related to renal graft deterioration, and histological lesions such as interstitial fibrosis and tubular atrophy overlap with those observed in aging kidneys. Consequently, it has been proposed that kidney transplant senescence could contribute to graft loss. The process of cell senescence displays characteristics such as an increased expression of specific aging suppressor genes, shortened telomeres, mitochondrial changes, increased expression of negative regulators of the cell cycle, and immunological senescence. Additionally, tubular frailty characterizes the aged kidney, making it more susceptible to ischemia, reperfusion, toxic injury, and consequently, to inflammation. Moreover, renal tissue injury predisposes the older graft not only to progressive deterioration due to glomerular hyperfiltration, but also triggers acute rejection due to increased immunogenicity. In conclusion, renal graft senescence is a complex process, and its better understanding will help the nephrologist in its management in order to achieve a longer graft survival. PMID:27103042

  2. Diet and healthy ageing.

    PubMed

    McKevith, Brigid

    2005-12-01

    In the future there will be more people aged 65 years and over ('older adults'). Although the exact mechanisms underlying normal ageing are not fully understood, ageing is generally associated with an increase in chronic diseases, such as cardiovascular disease, diabetes, cancer and osteoporosis. It is becoming clear that it is possible to prevent, slow or reverse the onset of many these by modifying lifestyle factors such as diet. Studies of older adults in a range of countries have highlighted a number of areas in which dietary quality could be improved. It is important to identify dietary patterns in addition to specific dietary components that offer protection against chronic disease. The challenge in the area of diet and healthy ageing is twofold: first, there is a need to improve the diet of older adults; and second, as most chronic diseases begin earlier in life, there is a need to encourage other age groups to adapt their diet so they can enter old age in better health.

  3. Magnesium and healthy aging.

    PubMed

    Veronese, Nicola; Zanforlini, Bruno Micael; Manzato, Enzo; Sergi, Giuseppe

    2015-01-01

    Magnesium (Mg) is relatively stable in the intracellular compartment, although decreases linearly with advancing age. This begs the question as to whether Mg could be used as biomarker of aging. A biomarker of aging is a biological parameter of an organism that, in the absence of disease, better predicts functional capability at a later age than the chronological age. Bone and muscle Mg content might be useful biomarkers, but the need for biopsies and the heterogeneous distribution of Mg in bones and muscles strongly limit the application of these methods in clinical practice. Similar considerations can be made for urinary Mg assessment, particularly after a loading test. Markers of Mg in blood seem fairly unreliable as biomarkers of aging since they are strongly dependent upon renal function, do not reflect the intracellular Mg status, and, in some investigations, are within normal ranges although other Mg parameters are not. Other investigations (e.g. nuclear magnetic resonance with fluorescent probes) seem to be promising, but their availability remains limited. PMID:26446714

  4. Conclusions of the workshop

    SciTech Connect

    Ruggiero, A.G.

    1996-12-31

    During this Workshop, it was concluded that a Proton-Proton Collider with an energy of 100 TeV per beam and a luminosity of about 10{sup 35} cm{sup {minus}2} s{sup {minus}1} is feasible. The most important technical requirement for the realization of such a project is a large bending field. For instance, a field of 13 Tesla would be desirable. This is twice the field of the SSC superconducting magnets, which very likely may be achieved in a non-too-far future by extrapolation of the present technology. The design of this Collider would follow very closely the methods used for the design of the SSC and of the LHC, with the major noticeable difference that, because of the larger bending field and the larger beam energy, the performance is determined by the effects of the Synchrotron Radiation in the similar manner they affect the performance of an electron-positron collider. This fact has considerable beneficial consequences since it allows the attainment of large luminosity by reducing the beam dimensions at collision and by requiring, to some degree, less number of particles per beam. On the other end, the losses to synchrotron radiation are to be absorbed by the cryogenic system, and the vacuum system should be capable to cope with them. A more significant rf system may also be required. The cost is overwhelmingly important for a project of this size. It is possible to make an estimate of the cost of the collider alone, excluding the injector complex, by extrapolating from the experience acquired with the RHIC and SSC magnets. Thus, the cost estimate is more difficult, but it is not expected to exceed 10 billion dollars. This is only the technical cost of the components, to which other burden costs, of engineering, architectural and administrative nature, are to be added.

  5. Conclusions and Future Directions

    ERIC Educational Resources Information Center

    Lillibridge, Fred

    2012-01-01

    Benchmarking, when done properly, offers a lot of promise for higher education units that want to improve how they do business. It is clear that much is known, but still more needs to be learned before it reaches its full potential as a useful tool. Readers of this issue of "New Directions for Institutional Research" have been treated to useful…

  6. Conclusions and Further Readings.

    ERIC Educational Resources Information Center

    Lucas, John A.

    1979-01-01

    The components of a complete and effective marketing plan for higher education institutions are summarized. It is suggested that a marketing plan embrace all elements of the total marketing concept, and include curriculum evaluation, a retention program, and a scheme for evaluating the strategy's effectiveness. A bibliography is included.…

  7. Conclusion (The Mobile Future)

    NASA Astrophysics Data System (ADS)

    Marcus, Aaron; Sala, Riccardo; Roibás, Anxo Cereijo

    There are a couple of fundamental beliefs that I hold about the future of technology and media. First, I believe that, absolutely, most, if not all, media will be delivered, at least intermittently in its lifecycle, over an IP network. It is an efficient carrier, it is scalable, and it can be organically evolved. Whether this is IPV6 or some other technology is inconsequential, it will just work.

  8. Project Summary and Conclusions

    NASA Technical Reports Server (NTRS)

    Sawin, Charles

    1999-01-01

    A top level summary of activities conducted throughout the course of the EDOMP in response to initial concerns at the outset of the program is provided. Significant findings from the investigations are summarized, together with resulting countermeasures that were implemented and flight rules that were developed in response to these findings. Subsequent paragraphs provide more information; details will be found in the referenced sections.

  9. System performance conclusions

    NASA Technical Reports Server (NTRS)

    Arndt, G. D.

    1980-01-01

    The advantages and disadvantages of reducing power levels and using antennas with diameters smaller than 1 Km were evaluated if rectenna costs and land usage requirements become major factors, operating at 5800 megahertz should be considered. Three sequences (random, incoherent phasing, and concentric rings - center to edge) provided satisfactory performance in that the resultant sidelobe levels during startup/ shutdown were lower than the steady-state levels present during normal operations. Grating lobe peaks and scattered power levels were used to determine the array/subarray mechanical alignment requirements. The antenna alignment requirement is 1 min or 3 min depending on phase control configuration. System error parameters were defined to minimize scattered microwave power.

  10. Conclusion: Lessons learned

    ERIC Educational Resources Information Center

    Merritt, Karen; Lawrence, Jane Fiori

    2007-01-01

    Planning, opening, and bringing to life a new institution of higher education is a challenging undertaking. At UC Merced, it has been a daunting and exhilarating experience for its founding administration, faculty, staff, and students. Campus pioneers had no road map, no playbook to tell them how to plan and build in the twenty-first century a…

  11. Conclusions and Policy Directions,

    SciTech Connect

    Wilbanks, Thomas J; Romero-Lankao, Paty; Gnatz, P

    2011-01-01

    This chapter briefly revisits the constraints and opportunities of mitigation and adaptation, and highlights and the multiple linkages, synergies and trade-offs between mitigation, adaptation and urban development. The chapter then presents future policy directions, focusing on local, national and international principles and policies for supporting and enhancing urban responses to climate change. In summary, policy directions for linking climate change responses with urban development offer abundant opportunities; but they call for new philosophies about how to think about the future and how to connect different roles of different levels of government and different parts of the urban community. In many cases, this implies changes in how urban areas operate - fostering closer coordination between local governments and local economic institutions, and building new connections between central power structures and parts of the population who have often been kept outside of the circle of consultation and discourse. The difficulties involved in changing deeply set patterns of interaction and decision-making in urban areas should not be underestimated. Because it is so difficult, successful experiences need to be identified, described and widely publicized as models for others. However, where this challenge is met, it is likely not only to increase opportunities and reduce threats to urban development in profoundly important ways, but to make the urban area a more effective socio-political entity, in general - a better city in how it works day to day and how it solves a myriad of problems as they emerge - far beyond climate change connections alone. It is in this sense that climate change responses can be catalysts for socially inclusive, economically productive and environmentally friendly urban development, helping to pioneer new patterns of stakeholder communication and participation.

  12. Conclusions and Perspectives

    NASA Astrophysics Data System (ADS)

    Csermely, Peter

    “As Pity and I have been attending some religious education before our marriage, I have found you an excellent quotation: ‘And further, by these, my son, be admonished of making many books there is no end; and much study is a weariness of the flesh’ (Ecclesiastes 12:14). Don’t you think it is time to finish your book?” I have good news for you, Spite We are indeed approaching the end. In this, the last chapter I will first summarize everything we have learnt about the weak-link-induced stabilization of complex systems. Then I will spend some time redefining weak links and stability. Finally, another set of advice will follow: how to build proper links in your own life. Keep this advice, Spite. Your child may need it even more than you do.

  13. Conclusion of the Book

    NASA Astrophysics Data System (ADS)

    Koper, Rob; Sloep, Peter; Hummel, Hans; Vogten, Hubert; van Bruggen, Jan; Specht, Marcus; Greller, Wolfgang

    The aim of this book, as described in the introduction, is to help people to further develop their professional competences during their careers by using the innovative powers of new media, mobile devices, and modern Internet services. This is related to the question of how to become and stay employable as a professional, given the permanently changing knowledge and technologies, and the change of jobs and markets during their careers. We have explained that the traditional educational method is not always the most suitable for all types of learning and especially not suitable for every professional.

  14. The Cramster Conclusion

    ERIC Educational Resources Information Center

    Grams, Michael

    2011-01-01

    In a recent "TPT" article, I wrote about a website called "Cramster" (www.cramster.com), which provides students with solutions to homework problems from many textbooks in math and science. I proposed the following question: Could giving students the answers to their assigned homework problems be an effective way of teaching them physics? This…

  15. Conclusions: Future Directions.

    ERIC Educational Resources Information Center

    Jacobson, Harvey K.

    1978-01-01

    Various aspects of the institutional evaluation process are discussed including: pitfalls to avoid, choice of indicators, audience, accountability, futures research, technological change, program termination, data sources, longitudinal data, political aspects, advertising, marketing, and internal v external evaluators. (Author/SF)

  16. Space-Based Range Safety and Future Space Range Applications

    NASA Technical Reports Server (NTRS)

    Whiteman, Donald E.; Valencia, Lisa M.; Simpson, James C.

    2005-01-01

    The National Aeronautics and Space Administration (NASA) Space-Based Telemetry and Range Safety (STARS) study is a multiphase project to demonstrate the performance, flexibility and cost savings that can be realized by using space-based assets for the Range Safety [global positioning system (GPS) metric tracking data, flight termination command and range safety data relay] and Range User (telemetry) functions during vehicle launches and landings. Phase 1 included flight testing S-band Range Safety and Range User hardware in 2003 onboard a high-dynamic aircraft platform at Dryden Flight Research Center (Edwards, California, USA) using the NASA Tracking and Data Relay Satellite System (TDRSS) as the communications link. The current effort, Phase 2, includes hardware and packaging upgrades to the S-band Range Safety system and development of a high data rate Ku-band Range User system. The enhanced Phase 2 Range Safety Unit (RSU) provided real-time video for three days during the historic Global Flyer (Scaled Composites, Mojave, California, USA) flight in March, 2005. Additional Phase 2 testing will include a sounding rocket test of the Range Safety system and aircraft flight testing of both systems. Future testing will include a flight test on a launch vehicle platform. This paper discusses both Range Safety and Range User developments and testing with emphasis on the Range Safety system. The operational concept of a future space-based range is also discussed.

  17. Space-Based Range Safety and Future Space Range Applications

    NASA Technical Reports Server (NTRS)

    Whiteman, Donald E.; Valencia, Lisa M.; Simpson, James C.

    2005-01-01

    The National Aeronautics and Space Administration Space-Based Telemetry and Range Safety study is a multiphase project to demonstrate the performance, flexibility and cost savings that can be realized by using space-based assets for the Range Safety (global positioning system metric tracking data, flight termination command and range safety data relay) and Range User (telemetry) functions during vehicle launches and landings. Phase 1 included flight testing S-band Range Safety and Range User hardware in 2003 onboard a high-dynamic aircraft platform at Dryden Flight Research Center (Edwards, California) using the NASA Tracking and Data Relay Satellite System as the communications link. The current effort, Phase 2, includes hardware and packaging upgrades to the S-band Range Safety system and development of a high data rate Ku-band Range User system. The enhanced Phase 2 Range Safety Unit provided real-time video for three days during the historic GlobalFlyer (Scaled Composites, Mojave, California) flight in March, 2005. Additional Phase 2 testing will include a sounding rocket test of the Range Safety system and aircraft flight testing of both systems. Future testing will include a flight test on a launch vehicle platform. This report discusses both Range Safety and Range User developments and testing with emphasis on the Range Safety system. The operational concept of a future space-based range is also discussed.

  18. Aging & Health.

    PubMed

    2016-09-01

    By 2050 an estimated 83.7 million Americans will be ages sixty-five and older, up from 40.3 million in 2010. The shock wave of aging Americans will have profound implications for older people, their families, health care providers, and the economy. Researchers, policy makers, health care leaders, and others are designing responses to the challenges these actuarial shifts will create. For example, delivering health care at home could help keep more older Americans out of costly emergency departments and nursing homes. But such steps require more health care providers, a broader distribution of providers than currently exists, and better use of the resources we have. PMID:27605632

  19. Cretaceous Olistostrome Model, Brooks Range, Alaska

    SciTech Connect

    Crane, R.C.

    1985-04-01

    The foothills area of the Brooks Range thrust belt in the area between the Itkillik River and the Etivluk River is composed dominantly of shallow, thrusted olistostrome sheets. Three olistostrome units can be recognized based on the dominant lithology of contained olistoliths and age of the matrix shales. The lower unit is Thithonian to mid-Valanginian in age and is characterized by abundant graywacke and turbidite, mafic rocks, black cherts, olistoliths of Norian-Rhaetic shales, Nuka sands, and glide sheets of Upper Devonian to Lower Mississippian rocks. Olistolights were derived from the Misheguk, Ipnavik, and Nuka Ridge allochthonous sequences. The middle unit is of late Valanginian age and has olistoliths of Norian shales; more abundant Upper Triassic chert; Otuk Formation; variegated, radiolarian, black and white cherts; Siksikpuk facies red, green and black shales; Upper Jurassic graywacke; and minor occurrences of mafic rocks. The unit is characterized by glide sheets of Triassic white and multicolor cherts. Olistoliths are derived from Nuka Ridge and Brooks Range sequences. The upper unit is Hauterivian in age and olistoliths included reworked material from all older units. Olistoliths are few and widely scattered. Isolated outcrops of white chert and conglomerate boulders are characteristic.

  20. Wide Range SET Pulse Measurement

    NASA Technical Reports Server (NTRS)

    Shuler, Robert L.; Chen, Li

    2012-01-01

    A method for measuring a wide range of SET pulses is demonstrated. Use of dynamic logic, faster than ordinary CMOS, allows capture of short pulses. A weighted binning of SET lengths allows measurement of a wide range of pulse lengths with compact circuitry. A pulse-length-conservative pulse combiner tree routes SETs from combinational logic to the measurement circuit, allowing SET measurements in circuits that cannot easily be arranged in long chains. The method is applied to add-multiplex combinational logic, and to an array of NFET routing switches, at .35 micron. Pulses are captured in a chain of Domino Logic AND gates. Propagation through the chain is frozen on the trailing edge by dropping low the second "enable" input to the AND gates. Capacitive loading is increased in the latter stages to create an approximately logarithmic weighted binning, so that a broad range of pulse lengths can be captured with a 10 stage capture chain. Simulations show pulses can be captured which are 1/5th the length of those typically captured with leading edge triggered latch methods, and less than the length of those captured with a trailing edge latch method. After capture, the pulse pattern is transferred to an SEU protected shift register for readout. 64 instances of each of two types of logic are used as targets. One is a full adder with a 4 to 1 mux on its inputs. The other is a 4 x 4 NFET routing matrix. The outputs are passed through buffered XNOR comparators to identify pulses, which are merged in a buffered not-nand (OR) tree designed to avoid pulse absorption as much as possible. The output from each of the two test circuits are input into separate pulse measurement circuits. Test inputs were provided so that the circuit could be bench tested and calibrated. A third SET measurement circuit with no inputs was used to judge the contribution from direct hits on the measurement circuit. Heavy ions were used with an LET range from 12 to 176. At LET of 21 and below, the very

  1. First Conclusions of the WPEC/Subgroup-22 Nuclear Data for Improved LEU-LWR Reactivity Predictions

    SciTech Connect

    Courcelle, Arnaud

    2005-05-24

    This paper is a summary of a collective work in the framework of the Working Party in International Nuclear Data Evaluation and Co-operation (WPEC) to investigate the reasons for systematic reactivity underprediction of thermal LEU-LWR (Low-Enriched Uranium, Light-Water Reactor). This keff underprediction ({approx_equal} -500 pcm) is observed with the most recent nuclear data libraries (ENDF/B-VI.8, JENDL3.3 and JEFF3.0) This report reviews the evaluation work performed at several laboratories [Oak Ridge National Laboratory (ORNL), Los Alamos National Laboratory (LANL), Commissariat a l'energie atomique de Bruyeres-Le-Chatel (CEA-BRC), International Atomic Energy Agency (IAEA)] as well as the integral tests (mainly at LANL, Knoll Atomic Power Laboratory (KAPL), Bettis Atomic Power Laboratory (BAPL), Nuclear Research and Consultancy Group NRG-Petten, CEA and IAEA) of the successive versions of the new evaluated files. The present status of the work can be summarized as follows: Improved evaluations of 238U inelastic data proposed by LANL and CEA-BRC were tested against integral benchmarks and partially improve the reactivity prediction. The thermal capture cross-section of 238U has been revised, and a new evaluation of 238U resonance parameters, up to 20 keV, is in progress at ORNL. Integral tests have ensured that the modifications of 238U capture cross-section in the thermal and resolved range were still compatible with 238U integral measurements (238U capture rate ratios measured in critical facilities and 239Pu build-up prediction in a depleted pressurized water reactor (PWR) assembly).It is demonstrated that the combination of the new inelastic data (LANL or BRC) with the preliminary ORNL resonance parameter set gives a good correction of the reactivity under-estimation. The provisional conclusions of this collective work are expected to contribute toward the improvement of the future versions of nuclear data libraries.

  2. 2011 NASA Range Safety Annual Report

    NASA Technical Reports Server (NTRS)

    Dumont, Alan G.

    2012-01-01

    Welcome to the 2011 edition of the NASA Range Safety Annual Report. Funded by NASA Headquarters, this report provides a NASA Range Safety overview for current and potential range users. As is typical with odd year editions, this is an abbreviated Range Safety Annual Report providing updates and links to full articles from the previous year's report. It also provides more complete articles covering new subject areas, summaries of various NASA Range Safety Program activities conducted during the past year, and information on several projects that may have a profound impact on the way business will be done in the future. Specific topics discussed and updated in the 2011 NASA Range Safety Annual Report include a program overview and 2011 highlights; Range Safety Training; Range Safety Policy revision; Independent Assessments; Support to Program Operations at all ranges conducting NASA launch/flight operations; a continuing overview of emerging range safety-related technologies; and status reports from all of the NASA Centers that have Range Safety responsibilities. Every effort has been made to include the most current information available. We recommend this report be used only for guidance and that the validity and accuracy of all articles be verified for updates. Once again the web-based format was used to present the annual report. We continually receive positive feedback on the web-based edition and hope you enjoy this year's product as well. As is the case each year, contributors to this report are too numerous to mention, but we thank individuals from the NASA Centers, the Department of Defense, and civilian organizations for their contributions. In conclusion, it has been a busy and productive year. I'd like to extend a personal Thank You to everyone who contributed to make this year a successful one, and I look forward to working with all of you in the upcoming year.

  3. Long-term clearance from small airways decreases with age.

    PubMed

    Svartengren, M; Falk, R; Philipson, K

    2005-10-01

    The prevalence of respiratory symptoms increases with age. Age has been found to be negatively associated with large airway clearance. The small airways region is considered important for development of airway disease. Clearance after the first 24 h was studied in 46 healthy subjects with a wide age distribution, (mean 42, range 19-81 yrs). All subjects inhaled monodisperse 6 microm Teflon particles labelled with 111In, with an extremely slow inhalation flow (0.05 L.s-1). The particles were mainly deposited in the small conducting airways. Lung retention was measured at 0 and 24 h, and at 7, 14 and 21 days after inhalation. Significant relationships were found for the individual 24 h "large" airway clearance in per cent of initial lung deposition with age, forced expiratory volume in one second and forced vital capacity. Age was negatively associated with "small" airway clearance after 24 h as estimated at 2, 7, 14 and 21 days. Using stepwise linear regression only age remained significantly associated to clearance. In conclusion, small airway clearance over 21 days was found to decrease with age. This might be one factor associated with the high prevalence of respiratory symptoms associated among the elderly.

  4. Traumatic myiasis in free-ranging eland, reported from Kenya

    PubMed Central

    2013-01-01

    Background For centuries, immature stages of Dipterans have infested humans and animals, resulting in a pathological condition referred to as myiasis. Myiases are globally distributed but they remain neglected diseases in spite of the great medical and veterinary importance. Moreover, there is a paucity of information on the clinical-pathology and/or epidemiology of the infestation, especially in African free ranging wildlife. Findings In the present study we report for the first time an outbreak of traumatic cutaneous myiasis (caused by Old World screwworm, Chrysomyia bezziana and blowfly, Lucilia sp.) in free-ranging common elands (Taurotragus oryx). The infestation affected both animal sexes and different age classes, and had a negative impact on individual fitness as well as the overall health. Severely affected individuals were euthanized, while others were clinically treated, and apparently recovered. Conclusions This study indicates that myiasis-causing flies still exist in Kenya and are able to cause severe outbreaks of clinical cutaneous myiasis in wild animals. The status of these parasites in Kenya, which are of zoonotic potential, are either unknown or neglected. PMID:23566876

  5. 2013 NASA Range Safety Annual Report

    NASA Technical Reports Server (NTRS)

    Dumont, Alan G.

    2013-01-01

    Welcome to the 2013 edition of the NASA Range Safety Annual Report. Funded by NASA Headquarters, this report provides an Agency overview for current and potential range users. This report contains articles which cover a variety of subject areas, summaries of various activities performed during the past year, links to past reports, and information on several projects that may have a profound impact on the way business will be conducted in the future. Specific topics discussed in the 2013 NASA Range Safety Annual Report include a program overview and 2013 highlights, Range Safety Training, Independent Assessments, support to Program Operations at all ranges conducting NASA launch/flight operations, a continuing overview of emerging range safety-related technologies, and status reports from all of the NASA Centers that have Range Safety responsibilities. Every effort has been made to include the most current information available. We recommend this report be used only for guidance and that the validity and accuracy of all articles be verified for updates. As is the case each year, we had a wide variety of contributors to this report from across our NASA Centers and the national range safety community at large, and I wish to thank them all. On a sad note, we lost one of our close colleagues, Dr. Jim Simpson, due to his sudden passing in December. His work advancing the envelope of autonomous flight safety systems software/hardware development leaves a lasting impression on our community. Such systems are being flight tested today and may one day be considered routine in the range safety business. The NASA family has lost a pioneer in our field, and he will surely be missed. In conclusion, it has been a very busy and productive year, and I look forward to working with all of you in NASA Centers/Programs/Projects and with the national Range Safety community in making Flight/Space activities as safe as they can be in the upcoming year.

  6. Exploration and mating range in African Pygmies.

    PubMed

    Cavalli-Sforza, L L; Hewlett, B

    1982-07-01

    The distributions of exploration range and of mating range were studied among Aka Pygmies of the Central African Republic. Exploration range is defined and methods of estimation for single individuals suggested. A simple exponential distribution is found for individual Aka Pygmies, with variation of exploration range (the parameter defining mobility) with sex, age and ethnic affiliation. Distribution of distances from birthplace and place of residence are compared and show modest differences. The frequency of visits to a given place has also been studied. The average distance between birthplaces of mates is very similar to the mean exploration range. Correlations between individual exploration and mating ranges suggest that it is the male who may be choosing a marriage partner among Pygmies. A theory by Boyce, Küchemann & Harrison (1967) on the relations between "neighbourhood knowledge" and mating distance is inapplicable because of its reliance on the Pareto distribution, which does not apply in the present case, and of other unnecessary assumptions, but the general principle of a close relationship between exploratory activity and mating distance seems valid, at least in the present case. Suggestions are made for causes for the difference between the present distributions and those with other shapes observed in less primitive economies. PMID:7125597

  7. CONTROLS ON WATER CHEMISTRY OF AN OREGON COAST RANGE STREAM

    EPA Science Inventory

    Numerous factors may control losses of dissolved nutrients from forested basins in the Oregon Coast Range. Potentially important factors include forest composition, stand age, forest management, grazing, agriculture, sewage inputs and bedrock types, as well as others perhaps not...

  8. Haematological and biochemical reference intervals for free-ranging brown bears (Ursus arctos) in Sweden

    PubMed Central

    2014-01-01

    Background Establishment of haematological and biochemical reference intervals is important to assess health of animals on individual and population level. Reference intervals for 13 haematological and 34 biochemical variables were established based on 88 apparently healthy free-ranging brown bears (39 males and 49 females) in Sweden. The animals were chemically immobilised by darting from a helicopter with a combination of medetomidine, tiletamine and zolazepam in April and May 2006–2012 in the county of Dalarna, Sweden. Venous blood samples were collected during anaesthesia for radio collaring and marking for ecological studies. For each of the variables, the reference interval was described based on the 95% confidence interval, and differences due to host characteristics sex and age were included if detected. To our knowledge, this is the first report of reference intervals for free-ranging brown bears in Sweden. Results The following variables were not affected by host characteristics: red blood cell, white blood cell, monocyte and platelet count, alanine transaminase, amylase, bilirubin, free fatty acids, glucose, calcium, chloride, potassium, and cortisol. Age differences were seen for the majority of the haematological variables, whereas sex influenced only mean corpuscular haemoglobin concentration, aspartate aminotransferase, lipase, lactate dehydrogenase, β-globulin, bile acids, triglycerides and sodium. Conclusions The biochemical and haematological reference intervals provided and the differences due to host factors age and gender can be useful for evaluation of health status in free-ranging European brown bears. PMID:25139149

  9. Acceleration of the aging process by oxygen

    NASA Technical Reports Server (NTRS)

    Miquel, J.; Lunderen, P. R.; Bensch, K. G.

    1975-01-01

    Tissue changes induced by hyperoxia have been compared with those of normal aging. Results of investigations using male flies prompt conclusion that normal aging, radiation syndrome, and hyperoxic injury share at least one common feature--lipid peroxidation damage to all mambranes resulting in accumulation of age pigment.

  10. Effect of Parental Age on Treatment Response in Adolescents with Schizophrenia

    PubMed Central

    Opler, Mark; Malaspina, Dolores; Gopal, Srihari; Nuamah, Isaac; Savitz, Adam J; Singh, Jaskaran; Hough, David

    2013-01-01

    Background Advanced paternal age (APA) is associated with increased risk for schizophrenia, but its effect on treatment response has not been longitudinally studied. Methods Association of parental ages at the time of the child's birth with age of onset, initial symptom severity and treatment response (to placebo and three different weight-based doses of paliperidone ER) in adolescents with schizophrenia was assessed in a post-hoc analysis using data from a 6-week double-blind study, the primary results of which are published (NCT 00518323). Results The mean (SD) paternal age was 29.2 (6.2) years, range (16-50) and maternal age was 26.8 (5.7) years, range (17-42) at childbirth for the 201 adolescents (ages 12-17 years) included in the analysis. While parental ages were uncorrelated with age of onset or initial symptom severity, both maternal and paternal age showed significant effects on treatment response (p < 0.03) of all paliperidone ER arms versus placebo. Paternal age was significantly correlated to improvement in positive symptoms and maternal age significantly related to negative symptoms, although only paternal age remained significantly associated with the treatment response in analyses that included both parents’ ages. Conclusions APA was associated with greater treatment response to both paliperidone ER and placebo, but not to age of onset or initial symptom severity in adolescents with schizophrenia. The results support the contention that APA-related schizophrenia has distinct underpinnings from other cases. Further studies are required to explore the role of genetic and environmental factors, and their interactions, in treatment response in this complex disorder. PMID:24144440

  11. Inconsistent definitions of "urban" result in different conclusions about the size of urban carbon and nitrogen stocks.

    PubMed

    Raciti, Steve M; Hutyra, Lucy R; Rao, Preeti; Finzi, Adrien C

    2012-04-01

    There is conflicting evidence about the importance of urban soils and vegetation in regional C budgets that is caused, in part, by inconsistent definitions of "urban" land use. We quantified urban ecosystem contributions to C stocks in the Boston (Massachusetts, USA) Metropolitan Statistical Area (MSA) using several alternative urban definitions. Development altered aboveground and belowground C and N stocks, and the sign and magnitude of these changes varied by land use and development intensity. Aboveground biomass (live trees, dbh > or = 5 cm) for the MSA was 7.2 +/- 0.4 kg C/m2 (mean +/- SE), reflecting a high proportion of forest cover. Vegetation C was highest in forest (11.6 +/- 0.5 kg C/m2), followed by residential (4.6 +/- 0.5 kg C/m2), and then other developed (2.0 +/- 0.4 kg C/m2) land uses. Soil C (0-10 cm depth) followed the same pattern of decreasing C concentration from forest, to residential, to other developed land uses (4.1 +/- 0.1, 4.0 +/- 0.2, and 3.3 +/- 0.2 kg C/m2, respectively). Within a land use type, urban areas (which we defined as > 25% impervious surface area [ISA] within a 1-km(2) moving window) generally contained less vegetation C, but slightly more soil C, than nonurban areas. Soil N concentrations were higher in urban areas than nonurban areas of the same land use type, except for residential areas, which had similarly high soil N concentrations. When we compared our definition of urban to other commonly used urban extents (U.S. Census Bureau, Global Rural-Urban Mapping Project [GRUMP], and the MSA itself), we found that urban soil (1 m depth) and vegetation C stocks spanned a wide range, from 14.4 +/- 0.8 to 54.5 +/- 3.4 Tg C and from 4.2 +/- 0.4 to 27.3 +/- 3.2 Tg C, respectively. Conclusions about the importance of urban soils and vegetation to regional C and N stocks are very sensitive to the definition of urban used by the investigators. Urban areas, regardless of definition, are rapidly expanding in their extent; a systematic

  12. Sequential ranging: How it works

    NASA Technical Reports Server (NTRS)

    Baugh, Harold W.

    1993-01-01

    This publication is directed to the users of data from the Sequential Ranging Assembly (SRA), and to others who have a general interest in range measurements. It covers the hardware, the software, and the processes used in acquiring range data; it does not cover analytical aspects such as the theory of modulation, detection, noise spectral density, and other highly technical subjects. In other words, it covers how ranging is done, but not the details of why it works. The publication also includes an appendix that gives a brief discussion of PN ranging, a capability now under development.

  13. Age Relationship

    NASA Technical Reports Server (NTRS)

    2006-01-01

    12 June 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a group of impact craters in Aonia Planum, Mars. Remarkably, two of the craters are approximately equal in size, however, they clearly differ in age. The left (west) crater has a well-defined rim and its ejecta blanket overlies part of the less pronounced crater to its immediate east. The one with the ejecta blanket is younger. Other circular depressions in this bouldery scene are also old, eroded impact craters.

    Location near: 59.5oS, 78.5oW Image width: 3 km (1.9 mi) Illumination from: upper left Season: Southern Autumn

  14. Hearing Loss as a Function of Aging and Diabetes Mellitus: A Cross Sectional Study

    PubMed Central

    Park, Dong Choon; Kim, MyungGu; Chung, Ji Hyun; Kim, Sang Hoon; Yeo, Seung Geun

    2014-01-01

    Background Although hearing loss may be caused by various factors, it is also a natural phenomenon associated with the aging process. This study was designed to assess the contributions of diabetes mellitus (DM) and hypertension, both chronic diseases associated with aging, as well as aging itself, to hearing loss in health screening examinees. Methods This study included 37,773 individuals who underwent health screening examinations from 2009 to 2012. The relationships between hearing threshold and subject age, hearing threshold at each frequency based on age group, the degree of hearing loss and the presence or absence of hypertension and DM were evaluated. Results The prevalence of hearing loss increased with age, being 1.6%, 1.8%, 4.6%, 14.0%, 30.8%, and 49.2% in subjects in their twenties, thirties, forties, fifties, sixties, and seventies, respectively (p<0.05). Hearing value per frequency showed aging-based changes, in the order of 6000, 4000, 2000, 1000 and 500 Hz, indicating greater hearing losses at high frequencies. The degree of hearing loss ranged from mild to severe. Aging and DM were correlated with the prevalence of hearing loss (p<0.05). There was no statistically significant association between hearing loss and hypertension after adjusting for age and DM. Conclusions The prevalence of hearing loss increases with age and the presence of DM. Hearing loss was greatest at high frequencies. In all age groups, mild hearing loss was the most common form of hearing loss. PMID:25549095

  15. The Mitochondrial Basis of Aging.

    PubMed

    Sun, Nuo; Youle, Richard J; Finkel, Toren

    2016-03-01

    A decline in mitochondrial quality and activity has been associated with normal aging and correlated with the development of a wide range of age-related diseases. Here, we review the evidence that a decline in mitochondria function contributes to aging. In particular, we discuss how mitochondria contribute to specific aspects of the aging process, including cellular senescence, chronic inflammation, and the age-dependent decline in stem cell activity. Signaling pathways regulating the mitochondrial unfolded protein response and mitophagy are also reviewed, with particular emphasis placed on how these pathways might, in turn, regulate longevity. Taken together, these observations suggest that mitochondria influence or regulate a number of key aspects of aging and suggest that strategies directed at improving mitochondrial quality and function might have far-reaching beneficial effects.

  16. Adult male chimpanzees inherit maternal ranging patterns.

    PubMed

    Murray, Carson M; Gilby, Ian C; Mane, Sandeep V; Pusey, Anne E

    2008-01-01

    Space use often correlates with reproductive success [1, 2]. Individual site fidelity is ubiquitous across a variety of taxa, including birds, mammals, insects, and reptiles [3-9]. Individuals can benefit from using the same area because doing so affords access to known resources, including food and/or breeding sites. The majority of studies on site fidelity have focused upon strictly territorial species in which individuals range in well-defined, exclusive areas (e.g., [4, 9]). By comparison, the transient groups that define fission-fusion species allow for considerable flexibility in individual space use. Although there is evidence that individual space use can influence reproductive success [2], relatively little is known about individual ranging patterns in fission-fusion species. Here, we investigate three potential correlates of male site fidelity (age, habitat quality, and maternal space use) in wild chimpanzees (Pan troglodytes). We found that when alone, each male preferentially concentrated his space use near the area where his mother ranged when he was dependent. We suggest that solitary ranging allows males to avoid direct competition with conspecifics and that foraging in familiar areas maximizes foraging efficiency. These results highlight the importance of male foraging strategies in a species in which male ranging is typically explained in terms of mating access to females.

  17. Ranging Behaviour of Commercial Free-Range Laying Hens.

    PubMed

    Chielo, Leonard Ikenna; Pike, Tom; Cooper, Jonathan

    2016-01-01

    In this study, the range use and behaviour of laying hens in commercial free-range flocks was explored. Six flocks were each visited on four separate days and data collected from their outdoor area (divided into zones based on distance from shed and available resources). These were: apron (0-10 m from shed normally without cover or other enrichments); enriched belt (10-50 m from shed where resources such as manmade cover, saplings and dust baths were provided); and outer range (beyond 50 m from shed with no cover and mainly grass pasture). Data collection consisted of counting the number of hens in each zone and recording behaviour, feather condition and nearest neighbour distance (NND) of 20 birds per zone on each visit day. In addition, we used techniques derived from ecological surveys to establish four transects perpendicular to the shed, running through the apron, enriched belt and outer range. Number of hens in each 10 m × 10 m quadrat was recorded four times per day as was the temperature and relative humidity of the outer range. On average, 12.5% of hens were found outside. Of these, 5.4% were found in the apron; 4.3% in the enriched zone; and 2.8% were in the outer range. This pattern was supported by data from quadrats, where the density of hens sharply dropped with increasing distance from shed. Consequently, NND was greatest in the outer range, least in the apron and intermediate in the enriched belt. Hens sampled in outer range and enriched belts had better feather condition than those from the apron. Standing, ground pecking, walking and foraging were the most commonly recorded activities with standing and pecking most likely to occur in the apron, and walking and foraging more common in the outer range. Use of the outer range declined with lower temperatures and increasing relative humidity, though use of apron and enriched belt was not affected by variation in these measures. These data support previous findings that outer range areas tend to be

  18. The Effect of Foam Rolling Duration on Hamstring Range of Motion

    PubMed Central

    Couture, Grace; Karlik, Dustin; Glass, Stephen C; Hatzel, Brian M

    2015-01-01

    Musculoskeletal health benefits from flexibility training and maintaining a functional, or sport specific, range of motion is important to one’s overall fitness. Commercial foam rollers are commonly used in gyms, therapy clinics and homes, yet data are lacking on the optimal rolling duration and effect on range of motion. Purpose : The purpose of this study was to examine the effect of varied durations of a commercial foam roller treatment on hamstring range of motion. Methods : The knee extension range of motion of 33 college aged men and women (age= 20±1.5y, mass= 72.2±10.8 kg) was assessed after a short (2 sets of 10s) and long (4 sets of 30s) duration of hamstring self-administered myofascial release using a commercial foam roller. A one way ANOVA was performed to compare the mean knee extension angle for each condition to baseline measures. Results : Results indicated that neither the short duration (67.30 ± 10.60 deg) nor long duration (67.41 ± 10.81 deg) rolling condition produced significant increases in knee extension compared to baseline (67.70 ± 9.90 deg). Conclusion : Self-administered foam rolling for a total duration of up to 2 minutes is not adequate to induce improvements in knee joint flexibility. Contributing factors may include the amount of pressure imparted by the commercial roller as well as duration of treatment. PMID:26587061

  19. Positron range estimations with PeneloPET

    NASA Astrophysics Data System (ADS)

    Cal-González, J.; Herraiz, J. L.; España, S.; Corzo, P. M. G.; Vaquero, J. J.; Desco, M.; Udias, J. M.

    2013-08-01

    Technical advances towards high resolution PET imaging try to overcome the inherent physical limitations to spatial resolution. Positrons travel in tissue until they annihilate into the two gamma photons detected. This range is the main detector-independent contribution to PET imaging blurring. To a large extent, it can be remedied during image reconstruction if accurate estimates of positron range are available. However, the existing estimates differ, and the comparison with the scarce experimental data available is not conclusive. In this work we present positron annihilation distributions obtained from Monte Carlo simulations with the PeneloPET simulation toolkit, for several common PET isotopes (18F, 11C, 13N, 15O, 68Ga and 82Rb) in different biological media (cortical bone, soft bone, skin, muscle striated, brain, water, adipose tissue and lung). We compare PeneloPET simulations against experimental data and other simulation results available in the literature. To this end the different positron range representations employed in the literature are related to each other by means of a new parameterization for positron range profiles. Our results are generally consistent with experiments and with most simulations previously reported with differences of less than 20% in the mean and maximum range values. From these results, we conclude that better experimental measurements are needed, especially to disentangle the effect of positronium formation in positron range. Finally, with the aid of PeneloPET, we confirm that scaling approaches can be used to obtain universal, material and isotope independent, positron range profiles, which would considerably simplify range correction.

  20. Ranging Behaviour of Commercial Free-Range Laying Hens

    PubMed Central

    Chielo, Leonard Ikenna; Pike, Tom; Cooper, Jonathan

    2016-01-01

    Simple Summary Commercial free-range production has become a significant sector of the fresh egg market due to legislation banning conventional cages and consumer preference for products perceived as welfare friendly, as access to outdoor range can lead to welfare benefits such as greater freedom of movement and enhanced behavioural opportunities. This study investigated dispersal patterns, feather condition and activity of laying hens in three distinct zones of the range area; the apron area near shed; enriched zone 10–50 m from shed; and outer range beyond 50 m, in six flocks of laying hens under commercial free-range conditions varying in size between 4000 and 24,000 hens. Each flock was visited for four days to record number of hens in each zone, their behaviour, feather condition and nearest neighbour distances (NND), as well as record temperature and relative humidity during the visit. Temperature and relative humidity varied across the study period in line with seasonal variations and influenced the use of range with fewer hens out of shed as temperature fell or relative humidity rose. On average, 12.5% of the hens were observed on the range and most of these hens were recorded in the apron zone as hen density decreased rapidly with increasing distance from the shed. Larger flocks appeared to have a lower proportion of hens on range. The hens used the range more in the early morning followed by a progressive decrease through to early afternoon. The NND was greatest in the outer range and decreased towards the shed. Feather condition was generally good and hens observed in the outer range had the best overall feather condition. Standing, pecking, walking and foraging were the most commonly recorded behaviours and of these, standing occurred most in the apron whereas walking and foraging behaviours were recorded most in the outer range. This study supported the findings of previous studies that reported few hens in the range and greater use of areas closer